text:
All about the walls of Philly's Best Cheesesteak House hangs evidence of the long-standing sports rivalry between Tampa Bay and Philadelphia.
Bucs vs. Eagles, Lightning vs. Flyers and, of course, the Rays vs. Phillies.
On Friday, the day after the Tampa Bay Rays earned their first World Series win, restaurant owner Sheila Surrena, dressed in her best Rays T-shirt, fired up the stove in preparation for the lunchtime crowd. She admits she was a bit irritated when her husband, Angelo Martinez, walked in proudly wearing his beloved bright-red Phillies jersey.
But not surprised.
"All I can say is, he's got his team," Sheila said as she scraped her griddle. "And I've got mine. I believe in the Rays. I think they're going to make it."
Though it will likely be late in the week before the World Series winner is decided, the friendly sports tug-of-war between the couple will most likely endure for a long time to come.
For Surrena, 36, who grew up in Tampa, the home team always comes first. For Martinez, 45, who was born in Tampa but grew up a stone's throw across the Delaware River from Philadelphia in Camden, N.J., it's a bit more complicated.
"Don't get me wrong, I love watching the Bucs and Rays," he said. "But when they play against Philly teams, I have to follow my heart."
Which is why, when it comes to the World Series, Martinez is torn. He wants to cheer the astonishing fortunes of the Rays while staying loyal to his lifelong admiration for Philadelphia teams.
In a sense, he's been here before.
"When the Rays beat the Red Sox last week (to set up another Tampa Bay-Philadelphia matchup), I said, 'Here we go again,' " Martinez recalled.
"Think of it. The Bucs had to beat the Eagles to win the Super Bowl. The Lighting had to beat the Flyers to win the Stanley Cup. It seems like every Tampa Bay team has to go through Philly to win a championship."
That probably explains why Martinez's relationship with the City of Brotherly Love remains close to his heart.
Ten years ago, he stumbled across the tiny restaurant on Forest Oaks Boulevard and knew he had found a familiar taste of home - a restaurant that served the kind of cheesesteak that devotees consider to be something between magic and art.
Two years after signing on as a cook in the kitchen, he pulled together enough money to buy the place.
Although Martinez admits there are probably as many cheesesteak recipes as there are places that serve them, he likes to think that the version served at Philly's Best is the closest anyone in Hernando County will come to finding the genuine article.
He uses finely chopped top round beef mixed with white American cheese and served with or without chopped onions. And, of course, he uses the only rolls that a cheesesteak should ever rest upon - foot-longs shipped in from the famous Amoroso bakery in Philadelphia.
"I get people from Philly who tell me it's the best they've ever had down here," Martinez said. "That makes me proud to hear that."
The restaurant also serves as a sort of museum for Martinez's vast collection of Philadelphia sports memorabilia, including signed photos, magazine covers, collector cards and sports figurines of his heroes.
However, in order to keep the family peace, the collection shares equal space with his wife's favorite athletes from Tampa Bay.
A photo of legendary Flyers Hall of Fame goalie Bernie Parent hangs near a picture of an equally conflicted former Buc Mike Alstott, shown wearing a Phillies jersey at a game at the Phillies' spring training home in Clearwater.
A glass display case is equally divided between Bucs and Eagles items.
"We try to keep it fun between us," Martinez said. "The truth is, we probably get twice as many Tampa Bay fans in here as we do Philly fans. It wouldn't make much sense to keep everything too personal."
As for his prediction on how the World Series will play out? Martinez said his heart is leaning toward Philadelphia because of the city's long drought - 25 years - without a major sports championship.
But his head, and perhaps his business sense, tell him that the Rays will prevail.
"After all," he said, "this cheesesteak shop is in Florida."
Logan Neill can be reached at email@example.com or (352) 848-1435.


text:
Diagnosis and Staging of Neuroendocrine Tumors (NETs) Utilizing 68Ga-DOTATOC PET/CT Scan
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT03136328
Recruitment Status : Completed
First Posted : May 2, 2017
Results First Posted : January 30, 2019
Last Update Posted : March 7, 2019
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Neuroendocrine Tumors
|Drug: 68Ga-DOTATOC
|Phase 3
This is a prospective, Phase 2, single center study of participants with Neuroendocrine Tumors (NETs). Study participants will receive 68Ga-DOTATOC. DOTATOC is a somatostatin analogue that localizes on the somatostatin receptors expressed by NETs and is attached to a radioactive material called Gallium 68. Participants will undergo a PET/CT imaging study to investigate 68Ga-DOTATOC's suitability as a positron emission tomography (PET) imaging agent for NETs. The radiation (imaging) dose will be 111-185 megabecquerel (MBq) (3 - 5 mCi) ± 25%. All doses after labeling will be presented in buffered solution for intravenous injection. Imaging will start 90 ±30 minutes after injection.
Sensitivity and specificity of this imaging technique will be compared with those of conventional imaging modality including CT, MRI and In-111 Octreoscan performed within 6-12 months before or after PET/CT.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|11 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Diagnosis and Staging of Neuroendocrine Tumors (NETs) Utilizing 68Ga-DOTATOC PET/CT Scan
|Actual Study Start Date :
|May 16, 2016
|Actual Primary Completion Date :
|March 2017
|Actual Study Completion Date :
|March 2017
Experimental: 68Ga-DOTATOC PET/CT
Study participants will receive 68Ga-DOTATOC and undergo a PET/CT imaging study.
Drug: 68Ga-DOTATOC
The intervention is to administer 68Ga-DOTATOC PET/CT for detecting NET.
Other Name: Diagnostic test
- Sensitivity to Correctly Diagnose NET [ Time Frame: During imaging process ( approximately 120 minutes) ]Sensitivity to detect NET will be assessed and compared with conventional imaging modality. Sensitivity is the ability of an agent to indicate the presence and location of NET. The ability of 68Ga-DOTATOC to localize more effectively to somatostatin receptors and the exquisite spatial resolution of PET/CT should make easier detection of primary and metastatic neuroendocrine tumors and allow better measurement of tumor burden. Sensitivity is the percentage of accurately diagnosed NET cases. All participants underwent conventional imaging with either Computerized Tomography (CT) or Magnetic Resonance Imaging (MRI) as standard care prior to 68Ga-DOTATOC imaging.
- Specificity to Detect True Negative [ Time Frame: During imaging process ( approximately 120 minutes) ]A tumor is an abnormal growth of cells which can be malignant or not. NET tumors secrete hormones that will disrupt the normal ecology of the body. 68Ga-DOTATOC is extremely sensitive and specific to the receptors expressed by NET. These attributes are unique to 68Ga-DOTATOC and makes it the only imagining technique that can determine whether or not lesions detected by conventional imaging is due to NET involvement. 68Ga-DOTATOC is able to exclude disease involvement in lesions detected on CT/MRI; this ability to exclude disease involvement is called Specificity. The reported values indicate the specificity of 68Ga-DOTATOC, which is the percentage of tumors detected by conventional imagining that 68Ga-DOTATOC correctly determined were not due to NET involvement (i.e. identifying true negative for NET).
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Signed informed consent.
- Patients of either gender, aged ≥18 years.
- Karnofsky status ≥60.
- Life expectancy of at least 12 weeks.
- Histologically and/or clinically confirmed and/or suspicious of NET.
- A diagnostic CT or MRI of the tumour region or suspected area within the previous 12 weeks prior to dosing day is available.
- Somatostatin-analogue scintigraphy scan with result (positive or negative) within the last 12 weeks.
Recent Blood test results up to 4-6 weeks as follows:
- White Blood Cell (WBC): >2*109/L
- Haemoglobin: >8.0g/Dl
- Platelets: >50x109/L
- Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), and Alkaline phosphatase (AP) each less than, or equal to, 5 times its Upper Limit of Normal (ULN)
- Bilirubin less than, or equal to, three times its ULN
- Serum creatinine: within normal range or <120μmol/L for patients aged 60 years or older.
- Negative pregnancy test in women capable of child-bearing.
Exclusion Criteria:
- Known hypersensitivity to Gallium 68, DOTATOC or to any of the excipients of 68Ga-DOTATOC.
- Therapeutic use of any somatostatin analogue, including Sandostatin® LAR (Long Acting Release) (within 28 days) and Sandostatin® (within 2 days) prior to study imaging. If a patient is on Sandostatin® LAR a wash-out phase of 28 days is required before the injection of the study drug.
- Pregnant or breast-feeding women.
- Current somatic or psychiatric disease/condition that may interfere with the objectives and assessments of the study.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT03136328
|Principal Investigator:
|Charito Love, MD
|Montefiore Medical Center
Documents provided by Charito Love, Montefiore Medical Center:
|Responsible Party:
|Charito Love, Associate Professor of Radiology, Montefiore Medical Center
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|May 2, 2017 Key Record Dates
|Results First Posted:
|January 30, 2019
|Last Update Posted:
|March 7, 2019
|Last Verified:
|February 2019
|Individual Participant Data (IPD) Sharing Statement:
|Plan to Share IPD:
|Studies a U.S. FDA-regulated Drug Product:
|Studies a U.S. FDA-regulated Device Product:
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Molecular Mechanisms of Pharmacological Action

subset: commoncrawl


text:
About Bullbarrow
Bullbarrow Products are the market leaders in supplying and manufacturing a wide variety of wheelbarrows and gardening equipment in Europe.
The desire to meet our customers exact requirements ensures that we enjoy a steady and sustained growth in a competitive market.
Through consistent, relevant background research, we can offer our customers a very wide range of sizes and popular colours. From lightweight manoeuvrable models, to sturdy, heavy duty barrows where balance and lifting have been carefully researched. Across our range, we have an impressive 55 different varieties of wheelbarrow available.
All this, underpinned by a fully approved ISO quality assurance system means that customers can rest assured that they will receive quality products at competitive prices.
All wheelbarrows are manufactured in the UK.
Customer reviews for Bullbarrow
At Made to Last we understand how important customer care is. Our aim is to treat all customers in the same way that we would treat a close friend or a family member if they were buying from us.
It seems to be working well!
We are very proud to have been awarded the 2017, 2018 & 2019 Gold Trusted Service by Feefo, the independent ratings experts meaning that we have one of the highest service ratings levels amongst retailers in the UK.
The reviews below relate to our customer service and product quality for Bullbarrow exclusively and show you what our existing customers think about the supplier and us. On this page we only show a maximum of the 20 most recent reviews for this supplier. All product reviews can be seen on the product pages.


text:
Program (x64) hangs or crashes when opening damaged .pcap files with broken packet header (timestamp and sizes) and data. (It was UDP packets) Seems like there are no some checks for time or sizes validity. That causes buffer overrun or something like that.
asked 27 Feb '17, 14:07
Sounds like a bug. First be sure you're running the most recent version. If the problem still occurs then please file a bug report and attach the capture file there.
answered 27 Feb '17, 18:58
JeffMorriss ♦


text:
Stay More Save More
Enjoy a long stay at X2 Vibe hotels, and you'll get our very best deals – up to 28% off for stays of 7 nights or more, or up to 30% off for stays of 14 nights or more. Leave the outside world behind and immerse yourself in the comforts ambience, all with great savings on already-low prices.
Applicable for all X2 Vibe Hotels.


text:
Call for Submissions to the 2013 PBS Online Film Festival
The PBS Online Film Festival is back for its second year and Native American Public Telecommunications, Inc. (NAPT) wants you to be a part of it. NAPT is searching for the best in Native short films from American Indian and Alaska Native filmmakers across the country. As an organization, we'd like to help curate your short film into the larger submission process.
Last year, Horse You See by Melissa Henry (Navajo) won the online People's Choice Award.
If you'd like to submit your completed work for consideration in the 2013 PBS Online Film Festival, please contact NAPT and submit the associated deliverables as outlined below:
Email firstname.lastname@example.com with the subject line of "2013 PBS Online Film Fest Submission." In the body of the email, include the following deliverables:
- URL(s) and password (if required) to view an online version of your short film(s)
- Short films should be between three to five minutes in length
- Short film name and synopsis
- Crew names & titles, Tribal affiliations (if applicable), short bio for each crew member
- Two (2) signature images from the short film; Specs: 300 dpi, .jpegs
Deadline for submissions is 5 p.m. PT on Friday, September 28, 2012. Submissions that are selected for further consideration will be notified by the end of October, as well as submissions that may need to be revisited for consideration for future festivals.
Questions pertaining to the submission process, may also be emailed to email@example.com. NAPT is excited to see the amazing work that Indian Country is doing!


text: The impact of having training co-led by disabled people and people with mental health difficulties "It was a refreshing change - a disabled trainer knows more than anyone and could answer the questions honestly." "The training led by a person with a learning disability gave us a true reflection of the reality of their lives." "It was empowering to see Siraaj facilitate the training, he made it easy to learn." "Having disabled trainers gave it a more resounding impact and allows for a clearer understanding of issues and challenges faced." "The trainer's real life experiences are what brought it alive for me." "It makes it more real, learning disabled people are the only people who really know and it's great for them to share their own experiences." "It is so good to hear from someone with a learning disability instead of someone who thinks they know." "Having a person on the autistic spectrum lead the training made it real." "What was best for me was hearing opinions from people that actually experience such issues. Thought provoking – terminology section!" "Having disabled trainers gave the training greater impact, it also underlined ability not disability." "Great, inspired - more people with a learning disability should train support workers."


text:
Honiton Sea Angling Club celebrates a tremendnous past year at Awards Night
PUBLISHED: 08:52 27 March 2014 | UPDATED: 08:52 27 March 2014
Honiton Sea Angling Club held it's 2013 Presentation Night at the Hare and Hounds pub, writes Mike Spiller.
Some 60 plus members and their guests enjoyed a fabulous night which started off with a cracking carvery kindly supplied by the Hare and Hounds.
Club chairman Dennis Retter told the gathering that the club had enjoyed another great year with some good catches being made. He also said how pleasing it was that the membership had also remained steady through the year.
The chairman also announced that the club was now into it's 21st year and had two special guests attending the awards night in the form of Dave and Marcus James who run the 'Edwin John' and the 'Mary Ellen' charter boats out of Minehead.
The club have been using these boats since the mid-eighties and some great fish have come aboard over the years.
The presentation of some 90 awards were made by Marcus James straight after the meal.
The Senior Boat champion award went to Leon Rice (1244 points) and the runner-up I this category was James Trevett (1141 points).
The Senior Shore champion honour went to Dr Kim Gibbs (2453 points) and the runner-up spot was claimed by Ken Sparks (2386 points).
In the junior competitions; the shore section was won by Callum Hardwick (768 points) and the junior boat champion was Billy Roberts 66 points).
The best specimen fish caught through the year went to Paul Rouse who had a nice smoothound from the shore of 13lb 14 oz (173.4 per cent).
The best flatfish award went to John Stanford who recorded a nice brill of 6lb 10oz. The best specimen fish caught from a charter boat went to Richard Kemp who had a cracking garfish of 2lb 1oz.
On the ladies awards, the best fish from the shore award went to Chloe Rice with a golden grey mullet and the best fish from the boat section for a lady was a great black bream of just over 3lb for Jane Mews.
Anyone needing more details on the club should visit their website on www.honitonsac.co.uk or vist the Honiton SAC Facebook page.
Very soon casting tuition/practice will start again locally on Wednesday evenings. The club also operate a reduced parking permit system for it's members at Branscombe Beach car park.
The club will also be looking this year how it can get a few more juniors out fishing locally, perhaps with their parents coming along too!
If you value what this story gives you, please consider supporting the Midweek Herald. Click the link in the orange box above for details.


text:
World leaders in technical support surfaces for pressure injury prevention
You will have different requirements of your support surface depending on the end-use. Here we can help you find the right fabric for your specific product, from the most comprehensive range of medical support surfaces available in the world.
Dartex has developed medical support surfaces for each unique care need. From pressure area care, to patient transfer and infection control. We have comprehensive ranges of fabrics for use in hospital, care homes and independent living. Here we can propose the right solution for your care need.
We offer two distinct fabric ranges; Dartex Classic and Dartex Advanced Technologies, which provide specialist properties depending on the medical needs of the patient. Find out more about the right choice for your application using the navigation links on the right.
The knowledge bank is a resource for all our direct customers, end-users as well of course the health care community. We showcase our research, offer technical support including details of legislation and standards. We thought that a comprehensive glossary would also be useful. Look out for the community healthcare portal later this autumn.
Our latest blogs and updates here....
Our media centre is the hub for accessing our latest news & events, press releases, videos and much more. Look out for our podcasts coming soon.
Dartex is an international business, with transfer coating and transfer laminating manufacturing facilities on both sides of the Atlantic. We produce the highest quality fabrics for the world-wide healthcare market. All our fabrics are expertly engineered to be used in a variety of patient support surfaces.
Dartex Coatings Ltd.
Acton Close
Long Eaton
Nottingham, NG10 1FZ
United Kingdom
Phone: +44 (0)115 983 7676
Fax: +44 (0)115 973 6387
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This page states the Terms and Conditions (the "Terms") under which You may use the website located at www.dartexcoatings.com (the "Website").
Trelleborg Nottingham Ltd referred to as "We", "Us" or "Our" in these Terms, may revise these Terms at any time by updating this posting. You should visit this page periodically to review the Terms and Conditions because they are binding on You. Continued use of the Website constitutes Your agreement to all such revised Terms. If You do not accept the Terms and Conditions stated here, do not use the Website.
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5.2 To the extent permitted by law, We shall not be liable to You in contract, tort (including without limitation, negligence) and/or breach of statutory duty for any loss of profits, business, goodwill, reputation, revenue or business opportunity whether direct or indirect and for any other indirect or consequential (including economic) loss of any kind which You may suffer in connection with the Website or in connection with the use, inability to use or as a result of the use of the Website, any Websites linked to it and/or any materials posted on it.
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The provisions of these Terms are severable and distinct from one another, and, if at any time any of the provisions is or becomes invalid, illegal or unenforceable, the validity, legality or enforceability of the other provisions shall not in any way be affected or impaired.
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This Website is owned and operated by
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Acton Close
Long Eaton
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This policy (together with our Terms above set out the basis on which any personal data we collect from you, or that you provide to us, will be processed by us. Please read the following carefully to understand our views and practices regarding your personal data and how we will treat it. For the purpose of the Data Protection Act 1998 (the "Act"), the data controller is Data Protection Officer Dartex Coatings(DP Registration Number Z1755074).
We may collect and process the following data about you:
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Questions, comments and requests regarding this privacy policy are welcomed and should be addressed to:
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text: Outdoor clocks and outdoor thermometers are great decorations for any garden or patio. Many of our outdoor clocks and thermometers feature a garden them and will be a great accent to any homes outdoor decor. Not only do our clocks and thermometers make great decorations they help to tell the time and temperature outside. Our clocks and thermometers are available in a variety of different styles and finishes to match you home and garden decor. If you have any questions about our Outdoor Clocks and Thermometers available for sale, give us a call or send us an email.


text:
Johannes burg, December 15, 2015/ — Science knows no boundaries, and that includes gender as well as age. African women have once again displayed inventiveness and excellence when it comes to the sciences. The L'Oréal Foundation and UNESCO are proud to announce the recipients of the 2015 L'Oréal-UNESCO For Women in Science Sub-Saharan Africa Regional Fellowships. Through the great diversity of their research, this year's Sub-Saharan African Fellows highlight the changing face of scientific research and the new disciplines that are continually emerging, forging the next generation of For Women in Science fellows. These young researchers share the thrill of curiosity and discovery, and are strong believers that science can […]
12 female scientists from across Sub-Saharan Africa have been honoured for their work and impact in the scientific field
Samsung to Donate Solar Powered Internet School to Uganda
Samsung Electronics Africa has announced it will be taking part in the fifth Innovation Africa Summit taking place at...
Millions in Nigeria and Kenya Embrace Facebook on Mobile to Share and Connect with Others
Facebook has shared new statistics revealing that 2.2 million Kenyans use Facebook every day and 4.5 million each month,...
Digital security: Gemalto Releases Findings of First Half 2015 Breach Level Index
JOHANNESBURG-The world leader in digital security, today released the findings of the Breach Level Index for the first...
Significant Step Forward For Global Transparency as Open Contracting Partnership, World Wide Web Foundation, and Omidyar Network Announce Collaboration on First-Ever 'Open Contracting Data Standard
Washington-The creation of the first-ever "Open Contracting Data Standard" has been announced today. The development of a common standard for the disclosure of contracting data is a key pillar of the work of the Open Contracting Partnership (OCP) to promote disclosure and participation in public contracting – empowering citizens around the world to hold their governments to account for the estimated US $9.5 trillion they spend each year through contracts. The development of the Open Contracting Data Standard will come as a result of the collaboration of the Open Contracting Partnership and the World Wide Web Foundation (Web Foundation), supported by a grant from Omidyar Network. The World Wide Web […]Read more ›
Google Launches High Speed Internet Project in Uganda
By Joseph Elunya & Agencies Kampala-Google has kicked off a project to build high-speed fiber-optic networks in the Ugandan capital Kampala. Kampala has been choosen as the first beneficiary for the project which is to be implemented in places around the world that lack access to fast broadband connections. The initiative, dubbed Project Link, aims to provide faster and more reliable Internet connections in areas where the current infrastructure is inadequate or non-existent "Google is launching Project Link to bring faster, more reliable Internet to the places and people that need it. We chose to build in the modern capital of Kampala, Uganda, a dense urban center currently limited to […]Read more ›
Safaricom on the money and free internet pledge
Safaricom has announced it will give free Internet to schools in the government's laptop project after posting a 45percent rise in profit for the first half of 2013-14 to Sh11.3billion.
The growth was driven by a 49 percent growth in Short Message Services (SMS) as well as mobile data that increased by 43 percent in the period under review.Read more ›
Window 8 Smart Phone for Afrika
Smartphones in Africa still represent a very small percentage – 10 percent – of total phones across the continent. As a first critical step toward increasing the adoption of smart devices, Microsoft and Huawei are introducing the Huawei 4Afrika – a full functionality Windows Phone 8 which will come pre-loaded with select applications designed by Africans, for Africa.
The phone will be available in most of African countries by the end of the year.Read more ›
How US and UK Governments Hacked Google Data Center Links, Snowden Reveals
The US National Security Agency (NSA), in collaboration with the UK government's listening station GCHQ, has secretly broken into the main communications links that connect Yahoo and Google data centres around the world, according to interviews with knowledgeable officials and documents obtained from former NSA contractor Edward Snowden.Read more ›
TTCL to Become State Owned Company Again!
THE government has announced plans to wholly own Tanzania Telecommunications Company Limited (TTCL). This will enable the oldest and largest telecommunication company to roll well its plans, including becoming the market leader in the country.Read more ›


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Over four in ten Dutch people admit they save but don't know exactly why. The reason most often cited for building up a nest egg, though, is to ensure there are sufficient funds in the event of an emergency, according to a survey recently carried out by ABN AMRO on the savings habits of over 2,000 Dutch citizens. Nearly 16 per cent said they put money by to invest later in their home and household. The results of the survey also reveal that the Dutch rely on their savings accounts to go on holiday (8 per cent), repay their mortgage (5 per cent) and top up their pension.
Those having drawn on savings during the last twelve months often put that money towards their mortgage (43 per cent), while about 28 per cent said they anticipate putting all or part of their savings towards their mortgage in the next twelve months. In addition, 22 per cent are thinking about using their savings to make a major purchase in the coming year. Of those respondents who plan to use all or part of their savings in the near future, one in five said they would be doing so for investment purposes.
Alternatives to traditional savings account a good idea
Frans Woelders, Senior Managing Director of Retail Banking at ABN AMRO, says, "As the National Institute for Family Finance Information [or Nibud, as it's called in Dutch] concluded early in November, it's important to save so you have a buffer. However, savings accounts don't pay much interest at the moment. So for the millions of people in the Netherlands who already have a sufficient buffer, there are other ways to generate a higher return on their savings than they might think. One example is making higher mortgage payments. Mortgage interest rates are at an all-time low right now, but they're still several percentage points higher than the interest on savings. That's why, in many cases, higher mortgage payments make sense. Parents might also think about making cash gifts to their children to help them get on to the property ladder or cover their tuition fees, for instance. Savers might also consider the merits of investing some of their money if such a strategy fits with their individual situation. At any rate, I think the Dutch would do well to give some thought to alternatives to the traditional savings account."
The vast majority save for a rainy day
Nearly all Dutch citizens – 94 per cent, to be exact – have at least one savings account, but the average is two accounts per person. Some 56 per cent say they transfer funds to a savings account monthly, with 34 per cent admitting they save only if there's money left over. Those who don't save at all (56 per cent) say a lack of financial resources is the main reason, while 27 per cent cite the low interest earned on savings.


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Did Google Just Kill The Facebook Privacy Fiasco?
Mark Zuckerberg spent his 26th birthday doing something that may be looked back at as a significant milestone for the company: waiting out a Facebook privacy storm. In previous years, Mark Zuckerberg could have only wished for the privacy storms to pass over, as concessions were made as a result of each previous storm that passed through. This time though, an unlikely player may have just served as the victim in what has become a perfect media-fueled privacy storm: Google.
Google Takes The Fall
Just as the press was at the peak of its attack on Facebook for the company's latest changes, Google has volunteered itself for becoming the face of technological privacy blunders. At the end of the week, the company admitted to collecting "payload data" from public WiFi networks through the company's Street View cars. The company has now understandably come under attack for the move. It also couldn't have been better timing for Mark Zuckerberg, who just the day before, had a quote from a soon-to-be-released book about Facebook published on the web:
Let me paint the two scenarios for you. They correspond to two companies in the Valley. It's not completely this extreme, but they are on different sides of the spectrum. On the one hand you have Google, which primarily gets information by tracking stuff that's going on. They call it crawling. They crawl the web and get information and bring it into their systems. They want to build maps, so they send around vans which literally go and take pictures of your home for their Street View system. And the way they collect and build profiles on people to do advertising is by tracking where you go on the Web, through cookies with DoubleClick and AdSense. That's how they build a profile about what you're interested in. Google is a great company, but you can see that taken to a logical extreme that's a little scary.
Ironically, it was a direct attack on the exact program (Google Street View) that has become a source of privacy violations. It could not have been better timing. Mark Zuckerberg has essentially positioned Facebook as a better alternative to Google as the company doesn't go about tracking people, instead they collect voluntarily shared data:
If you allow people to share what they want and give them good tools to control what they're sharing, you can get even more information shared. […] This is one of the most important problems for the next ten to twenty years. Given that the world is moving toward more sharing of information, making sure that it happens in a bottom-up way, with people inputting the information themselves and having control over how their information interacts with the system, as opposed to a centralized way, through it being tracked in some surveillance system.
The Lesser Of Two Evils
When contrasted with Google's system, it's appears to be a much better alternative. Despite some of the more complicated issues that Facebook is wrangling with (in trying to accelerate people's willingness to share more information publicly), Facebook could actually come out as the victor, as it is perfectly contrasted to more aggressive (and questionable) tactics used by Google.
Honestly, it's a dangerous game. Consumers should not be forced to choose between the lesser of two evils. However the media is only focused on what drives eyeballs and if the majority of consumers choose to view Facebook's new privacy strategies as "last week's news" (with the help of the media), the latest Facebook privacy storm may indeed come to pass.
In fact, some people are already convinced that this storm is going to pass over. They have ceded defeat on behalf of Facebook users and are ready to move on to the next story (Google is looking like a pretty good target). While I hope the press chooses to continue to force what is a much needed conversation surrounding the protection of users, Google may have just given Facebook their first opportunity ever to weather a privacy storm.
The evil Google icon was found via Merodeando.


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Neonatal abstinence syndrome
As the global prevalence of opioid use has alarmingly increased, so has the incidence of neonatal opioid withdrawal syndrome (NOWS), which is associated with multiple maternal and neonatal factors. Although rarely fatal, newborn withdrawal can be associated with substantial morbidities in the first weeks of life if not properly managed.
When we invited the authors to write a Primer on neonatal abstinence syndrome, we wanted a comprehensive article that discussed all of the issues at hand, including a description of placental biodisposition of substances, how the placental transfer of the metabolites affects the developing foetus and the immediate effects that the cessation of prenatal exposure to such substances might have on the neonate, as well as the long-term effects that this exposure might have on the child.
Several substances assumed by a pregnant woman can affect the child, but opioids are particularly dangerous as they readily pass through the placenta into the foetal circulation. Thus, the Primer focuses on neonatal abstinence syndrome caused by opioid use during pregnancy — neonatal opioid withdrawal syndrome (NOWS). Importantly, we also wanted the article to discuss the efforts and challenges to identify pregnant women who take opioids (whether or not under medical supervision), whose babies are at risk of developing NOWS, and the prenatal and substance use care these women need.
In this Primer, Coyle et al. have delivered all of this and more, with great clarity and accuracy. As the prevalence of opioid use, misuse, dependence and addiction continues to grow, the authors highlight the complexities (social and medical) of treating pregnant women with opioid dependence or addiction and stress the importance of supporting women during and after pregnancy to ensure optimal outcomes for the mother–child dyad.
By Lucia Brunello, Nature Reviews Disease Primer
Source: https://rdcu.be/bbRgb


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Akhilesh, K V and Bineesh, K K and Rajool Shanis, C P and Human, B and Ganga, U (2011) Rediscovery and description of the quagga shark, Halaelurus quagga (Alcock, 1899) (Chondrichthyes: Scyliorhinidae) from the southwest coast of India. Zootaxa, 2781. pp. 40-48.
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The present paper reports the first record of occurrence in the Arabian Sea and extension of distribution of Meganthias filiferus from the Thailand coast of the eastern Indian Ocean. A single specimen measuring 211 mm SL was collected from a commercial trawler operating in the Arabian Sea off the south-western coast of India during August 2008. The two known specimens of this rare species are compared
|Item Type:
|Uncontrolled Keywords:
|Rediscovery; description; quagga shark; Halaelurus quagga; Chondrichthyes; Scyliorhinidae; southwest coast; India
|Pelagic Fisheries > Pelagic Fishes
|CMFRI-Kochi > Marine Capture > Pelagic Fisheries
Subject Area > CMFRI > CMFRI-Kochi > Marine Capture > Pelagic Fisheries
CMFRI-Kochi > Marine Capture > Pelagic Fisheries
Subject Area > CMFRI-Kochi > Marine Capture > Pelagic Fisheries
|Depositing User:
|Arun Surendran
|Date Deposited:
|16 Dec 2011 04:43
|Last Modified:
|09 Sep 2015 15:51
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Stone River Estates
Community Information
Stone River Estates introduces a beautiful, tucked-away residential development within Royse City's premier golfing community. Homeowners will receive a 6-month paid membership Stone River Golf Course in Royse City TX and can live within a relaxed atmosphere with the convenience of an amazing golf course and clubhouse. Families can also enjoy quick and easy access to major shopping, popular restaurants as well as entertainment venues. This community is located just a short drive from Rockwall's popular shopping and restaurants as well. All of the homes we build in Royse City are built by our professional team of experts who have decades of experience in Dallas-Fort Worth and surrounding areas. Stone River Estates allows us to showcase our trademark home quality.
Children living in Stone River Estates attend Fort Elementary, Ruth Cherry Intermediate, Royse City Middle, and Royse City High Schools.
Area Information
Royse City, located in Rockwall County, has felt a boom of growth because of its convenient location on I-30. The city has a cultural heritage, which is meticulously preserved by the community. There are many local amenities to take advantage of, such as the Sabrina Creek Ranch, 45-acres of park land consisting of trails, playgrounds, practice fields and a city football stadium. Royse City Main Street gives residents the convenience of shopping, dining and entertainment. Families looking for the charm of an old town with modernized amenities, be sure to visit our communities in Royse City!
Learn more about the Stone River Golf Club in Royse City, by visiting their official website.
Model Address
Phone: (817) 268-9184
Fax: (817) 246-4342
From I-30 E: Head northeast on I-30 E. Take exit 77B for FM-35, then merge onto I-30 Frontage Rd. Turn right onto FM-35E. Turn left at the 1st cross street to stay on FM-35E. Turn right onto FM-2453, then turn right onto Rio Piedra Dr. Turn right onto Llano Dr., and the model is on your left.
School District
Royse City ISD
Driving Directions


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Fundraising morning at children's nursery in Chatteris raises funds for cancer charity
PUBLISHED: 10:01 26 December 2018
A festive family fundraiser at a children's nursery in March raised £154 for charity.
The team at Clarence House chose to support and fundraise for St Barnabas Hospice throughout their Christmas celebrations as they "do such an amazing job looking after cancer patients and their families throughout their time in need."
Charlotte Walton, nursery manager, said: "Many present and future families turned up to the event and joined in with creative crafts including a shaving foam Christmas tree, making magical reindeer food and Christmas tree decorations decorating.
"Staff organised a huge cake sale and sold many raffle tickets.
"We would like to thank all of the companies that donated raffle prizes and to all of the families that turned up to support us. We raised an incredible £154 which gives Clarence House Day nursery a total of £540.42."
The fundraiser was held on Sunday December 16.
If you value what this story gives you, please consider supporting the Cambs Times. Click the link in the orange box above for details.


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Jaws Of The Mountain
|Type: Earth Templar Attack Spell
|Range: Single PC or Mob
|Cost: 30 Mana
|Lag: 1 Round
|Duration: Instantaneous
Syntax: Cast 'Jaws of the Mountain' <target>
An earth templar who is underground may call upon the might of the earth
itself to gnash at his foe, calling forth stalactites and stalagmites to
pierce them between. There must be a fully solid floor and ceiling to cast
this spell, and the spikes from the floor will additionally deal movement
damage. The lower spikes will do less damage to flying targets, but it is
impossible to avoid them entirely this way.
page revision: 0, last edited: 21 Sep 2017 12:41


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"But there is greater comfort in the substance of silence than in the answer to a question." - Thomas Merton
Super casual outfit post today. It is easy, simple, breezy and the epitome of comfortable attire. I have on a black apron midi slip dress with leather slides. Added a faux leather tie wrap choker and aviator sunnies to complete my casual ensemble.
What I Wore
Dress : Target
Slides : NAYA
Choker : Forever 21


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- You're going to start that business.
- You're going to go for that promotion.
- You're going to start dating again.
- You're going to hire that new employee.
- And so on…
But then something happens. "Reality" sets in and you begin to wonder if you're really ready to take that next step. Then, you utter these words:
"I'm not sure if I'm ready yet."
Maybe you say them out loud or, perhaps, they get locked into your brain where you put them on loop. Either way, those words lead to the single outcome of paralysis.
Let me give you a little insight: readiness in advance of an action is a myth. You can never be fully ready.
Was I ready to be a husband? No. Was I ready to be a father? No. Was I ready to be a business owner? No.
But that's not very helpful, is it? So let's look at one more. Is a soldier ready for battle after going through bootcamp? No. You see, the goal of the military commanders is not to make soldiers ready for battle, it's to prepare them to perform in battle. Please don't miss this: you are never ready for something until after you've already experienced it. Instead, the best you can hope for is to be prepared for the experience. I've spoken with people who have served in the military and they've confirmed that they were never ready for live battle until after they had actually experienced it.
Readiness is a myth. As long as you hold it as the benchmark for how you must feel before taking action, you will never take action because you will never feel ready until after you've experienced the very thing you have yet to actually do.
Back to my examples. I wasn't ready to be a husband but I've been married for 12 years now and I never question whether I feel ready anymore. I wasn't ready to be a father but I've been one for all of three weeks and I feel ready now. I wasn't ready to start a business four years ago but readiness never crosses my mind. They only thing that changed was that I actually did what it was that I felt I wasn't ready to do.
And this is my encouragement to you: don't wait until you're ready because you'll never feel ready until after you've already done it. Instead, focus on preparation and, when you are prepared, take action.
Is there one area in your life that you've been waiting for readiness when you should be looking for preparedness?
Photo courtesy of the United State Marine Corp.


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Tributes to Jade Anderson after Atherton dog attack
- Published
Tributes have been paid to a 14-year-old girl who died after she was attacked by a pack of "out of control" dogs at a house in Greater Manchester.
Jade Anderson was found alone with five of the animals at a house she was visiting in Chaucer Grove, Atherton, Wigan, on Tuesday afternoon.
Police, who have spoken to the owners but made no arrests, said armed officers destroyed four dogs.
Fred Longworth High School said staff and pupils were "deeply shocked".
MPs have called for urgent reform of dog control laws, with the government suggesting new legislation may be brought in as quickly as possible.
'Lively and popular'
Friends of the teenager are set to release lanterns outside the school in Tyldesley later.
Head teacher at Jade's school, Jan Garretts, said the teenager had only been a pupil since the summer but had been making excellent progress.
"Obviously we are all shocked and saddened by Jade's tragic death," she said.
"She was very lively, very popular, she made lots of friends even in the short time she was actually here.
"She loved music, she loved dancing, we have an after school dance club and she was a regular at that and really enjoyed it.
"We hoped she had a great future ahead of her and she was making excellent progress."
She added: "Fred Longworth High School always regards itself as one big family, we will all pull together and support one another."
She said the school, which is currently closed for the Easter break, would be open on Wednesday and Thursday to pupils in need of support.
Flowers have been left outside the two-storey terraced house where the incident took place, and messages from friends have been posted on Facebook.
'Siginificant police presence'
Police said Jade's body was found at the house just after 14:00 GMT.
A post-mortem examination was due to take place on Tuesday night but officers said her injuries were "consistent with having been attacked by dogs".
Four dogs, believed to be two bull mastiffs and two Staffordshire bull terriers, were shot by police marksmen.
A fifth dog was contained at the house and not destroyed.
Police are continuing enquiries to determine the particular breed of the dogs but said they initially appear to be legal.
A Greater Manchester Police spokesman said: "Officers attended and found the body of a 14-year-old girl.
"They were confronted by a number of dogs that were aggressive and out of control."
Supt Mark Kenny said there would be a "significant" police presence in the area to reassure residents.
"First and foremost, our thoughts are with the family of the girl who has tragically lost her life. Specialist officers are offering them every support," he said.
"I understand this is an extremely distressing incident for all concerned, including the community, and we will work hard to establish the full circumstances that led to this tragedy."
He said it was too early to say any criminal offences had been committed.
Friends paid tribute to the "quiet" and "timid" teenager, who is thought to have visited the shops and returned to the house with a meat pie when she was attacked.
More than 4,500 people joined a Facebook group set up in Jade's memory.
'Overhaul' needed
One of those was the aunt of four-year-old John-Paul Massey, who was killed by a banned breed of dog in Liverpool in 2009.
Tricia Massey wrote: "Such a tragic thing to happen. I know what your poor family must be going through and how they are feeling, I lost my four-year-old nephew three years ago.
"He was killed by a dangerous dog in Liverpool. Something needs to be done about these aggressive animals."
Pet charity Blue Cross has called for a change in laws governing dangerous dogs.
Chief executive Kim Hamilton said: "This tragic loss of a young life is an extremely distressing reminder that current dangerous dog legislation puts people at risk.
"All our thoughts are with Jade's family and friends but until we see a radical overhaul of the law that allows authorities to step in at the first sign of aggressive behaviour these shocking incidents will continue to happen."
The Department for Environment, Food and Rural Affairs estimates about 210,000 people are attacked by dogs in England every year.
Five children and one adult have been killed by dogs on private property since 2007.


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Also known as Picante de Papas, this dish is often made in Latin American countries using a tropical sweet potato known as a boniato. Enjoy this with pork chops.
How to Make It
Heat olive oil in a Dutch oven over medium heat. Add celery, fennel, and garlic; cook 1 minute, stirring constantly. Add onion and the next 4 ingredients (through chile); cook 10 minutes, stirring frequently. Add potato and water; bring to a boil. Cover, reduce heat, and simmer 35 minutes or until potato is tender. Sprinkle with cilantro.


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Strategic Partners
We work with a select group of consulting firms that allow us to fill a wide variety of client needs - from small customized engagements to global, muti-year learning & development programs.
We have worked with Proteus International since 2007. They are dedicated to preparing leaders for the future by helping them get clear about their vision and then consistently choosing the simplest, most feasible ways to make that future a reality.
Proteus has three areas of expertise: Strengthening Leaders, Developing Vision & Strategy, and Building Skills & Knowledge. Their training programs are used by some of the most successful companies in the world. For more information about Proteus, visit their website.
We've worked with Duke Corporate Education since 2005 to design and deliver world-class custom executive education for global corporations. Duke CE has been voted the #1 Provider of Custom Executive Education for the past 12 years by both Business Week in the US as well as by the Financial Times in the UK. They are our primary partner for large global deliveries of custom executive education programs.
Duke CE is headquartered in Durham, North Carolina (US), and has additional offices in San Diego, California (US), London (UK), Johannesburg (South Africa), Ahmedabad (India), and Singapore. For more information about them and their work, visit their website or brochure.
Melbourne Business School is the premiere Executive Education provider for Asia Pacific. We've partnered with them to deliver programs here in the Americas for some of their global clients. For more information about them and their work, visit their website.
Sloan Group International provides large-scale coaching programs globally. We have worked with Karlin Sloan and her international team since 2005. You can find out more about their work on their website.
Learning at the speed of change.
If learning is "sticky," change can happen.
Actionable was founded in 2008 on the belief that great ideas are wasted unless they're applied. We're on a mission to help teams get more out of their learning programs by using technology and behavior science. Employees leave training with a commitment to behavior change that our platform helps them turn into a habit over the next 30 days.
The Actionable Platform provides three key components that are essential for turning learning into new behaviors to drive business outcomes:
1) Learning relevant to the unique context of every team.
2) Daily nudges to drive individual behavior change.
3) Data to provide leading indicators of change success.


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My fellowship period at Dumbarton Oaks has been a time of great academic productivity on many fronts, not least of them my central project, "Building Time: The Origins of Dynastic Kingship in the Maya Lowlands." This book is an exploration of Maya temporality, social memory, and politics and examines the roles played by architecture, imagery, text, and portable objects in the construction of royal origins and dynastic authority during the Classic period, and is grounded in data from excavations in the royal palace of Piedras Negras. My time at Dumbarton Oaks has allowed me to delve into the original excavation data from Piedras Negras, to re-evaluate assessments and interpretations that I made in writing my dissertation on the same subject, and to synthesize the work of other excavators who worked at the site. In the course of this synthesis I have been able to make unexpected findings in the data that provide new insights into the growth and collapse of the Piedras Negras kingdom generally. This work, in addition to helping me to advance Building Time, has also allowed me to complete approximately half of a monograph on the archaeology of the Piedras Negras Acropolis, to be co-authored with Stephen Houston.
Charles Golden, Brandeis University, Fellow 2007–2008


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October 22, 2016
Gortnahown Farm
https://www.mudrunguide.com/event/county-cork-ireland-dhillbillies-mud-run-2016/ Gortnahown Farm, Junction 13 on the M8 motorway, Gortnahown, Cork, Ireland Dhillbillies Mud Run firstname.lastname@example.com use-title true MM/DD/YYYY
Race Start Time:
Event starts at 9:00am
Venue:Gortnahown Farm
Junction 13 on the M8 motorway
Gortnahown, Cork, Ireland - View Map
Distance & Course Length:
Organizer:Dhillbillies Mud Run An adventure/race over man made and natural obstacles.
It is approx 6km course designed to be suitable for reasonably fit men and women, over 16's.
This is a charity event, being hosted by Mitchelstown Lions Club with all proceeds in aid of Mercy Cancer Appeal.
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Click here to read or add your own County Cork Ireland D'hillbillies Mud Run 2016 reviews
Registration:Visit Event Website
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Who's Attending?
Cost & Pricing:
|Individual Cost
|Team of 6-19 people Cost
|Team of 20+ people Cost
|Registration Closes
|All prices are per runner.
Course Description:
It is set to be a whole load of mucky fun with participants running, crawling, scrambling and sliding over the obstacles throughout the wet and wild course (6km & 12km).
Aid Stations:
Aid stations available on course
Spectators are welcome!
Come with a sense of adventure!
Coupons / Discount Codes:
Please see our obstacle course race discount & promotion page for all the latest discounts, promos, promotions, discount codes, and coupon codes for County Cork Ireland D'hillbillies Mud Run 2016. There also may be one listed at the top of this page.


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Brain Development, Cell Phones and Wireless
Scientific Research on the Neurotoxic Effects of Wireless Radiation
Research indicates that exposure to wireless radiation can harm the brain. Experiential research has found that exposure reduces brain cells and causes brain cell death in the memory and learning centers of the brain. Research also has fund DNA damage in the brain from EMF exposures. This scientific evidence of a neurotoxic effect- meaning adverse effects on the brain and brain development – has profound implications for our children's health future.
This webpage briefly summarizes this research, followed by a list of research studies so that you can share the scientific documentation in your community.
Altered Brain Activity
Contrary to reports that this radiation has "no effect" research clearly shows that exposure results in changes in brain activity. In 2011, NIH research found just 50 minutes of a wireless transmitting device (cell phone) next to the brain increases glucose metabolism in the part of the brain most exposed. This study made headline news and Dr. Volkow recommended that people reduce direct exposure to their brains. She also stated that there was an "urgent need" to do additional research. Preliminary research on 3G and 4G has further shown that non-thermal levels of this radiation alter the brain's electrical activity.
Damaged Brain Development, Hyperactivity and Memory Problems
Dr. Taylor of Yale Medicine and colleagues found that when mice were exposed to cell phone signals while pregnant, their offspring then showed increased hyperactivity and impaired memory. In addition, his neurological tests revealed abnormal brain development. Research on humans has also found higher cell phone radiation exposure associated with higher behavioral problems.
Damaged Brain Cells
Research from Turkish scientists Bas, Odaci, Sonmez, Kaplan and colleagues found significant brain cell damage within the hippocampus and cerebellum of rats following exposure to cell phone radiation frequencies. Many of these studies exposed rats to radiofrequency (RF) for only one hour a day for one month. After exposure, the animals brains were carefully examined using a state of the art stereological technique that counts brain cells to investigate the effects of exposure. Sonmez, et al. state the age of their test animals is comparable to human teenagers, and thus their results suggest the human teenage brain is sensitive to chronic mobile phone exposure. These significant research results prompted Dr. Suleyman Kaplan to file a comment to the US FCC review of human exposure to radiofrequency radiation in which he summarizes his recent research showing neurological damage after exposure. Dr. Kaplan states his research, along with others, is evidence that current FCC standards are not adequate for children and teenagers due to their increased sensitivity to RFR and chronic lifetime exposure.
A follow up study by researchers from the Ondokuz Mayıs Medical School examining electromagnetic field effects on the human hippocampus reported that subjects with high cell phone exposure showed a significant lack of attention and concentration in comparison to the low exposure group.
Combined Exposures Increase Effects on the Brain
Research investigating cell phone radiation in combination with the heavy metal lead- which is a known neurotoxin- has found that children with blood lead levels had higher ADHD like symptoms if they also had higher cell phone use. This finding lead the researchers to consider a potential synergetic effect between lead and radiofrequency (RF) fields, meaning the RF exposure increased the effects from the lead exposure. In fact, multiple research studies have found that electromagnetic fields can increase the effects of a known toxic exposure. Researchers have repeatedly found a tumor promotion effect from EMF. Please visit EHTs webpage on the synergistic effects of EMFs to learn more about research that has found EMF's in combination with other environmental toxins results in increased adverse health effects.
Damage to the Blood Brain Barrier
Radiofrequency radiation exposure has also been shown to affect the permeability of the blood-brain barrier (BBB), as well as altering the expression of microRNA within the brain, which researchers state could lead to adverse effects such as neurodegenerative disease. When the BBB is more permeable, more toxins circulating in the blood can reach the brain.
In 2009, Dr. Leif Salford a neurosurgeon at Lund University Hospital and Chairman of the Department of Neurosurgery presented his published research studies that found blood-brain barrier (BBB) leakage after very very low levels of exposure. These studies have been confirmed and expanded on by researchers from China who concluded, "these results demonstrated that exposure to 900 MHz EMF radiation for 28 days can significantly impair spatial memory and damage BBB permeability in rat by activating the mkp-1/ERK pathway." Decades ago, Dr. Allen Freys 1975 research found exposure impacted BBB permeability. His published article explains how these important findings were followed by suppression, misinformation and a shutdown of government funded research in the United States.
Dr. Seyhan and her team from Gazi University have published multiple studies assessing the impacts of radiofrequency radiation on the blood brain barrier as well as on DNA oxidative damage within the brain. Results indicate an increase in permeability and disruption of the BBB integrity following 20 minutes of RFR exposure at levels below the international limits. Furthermore, rats exposed to RFR simulating a 3G-mobile phone for 10 days (6h/day) showed increased DNA oxidative brain damage compared to controls. In 2012, Dr. Seyhan presented these findings at the National Press Club alongside five acclaimed experts and researchers.
DNA Damage
In 2016 and 2017, the National Toxicology Program released findings of genotoxic effects in various brain regions of mice and rats exposed to daily low levels of radiofrequency radiation. These research findings parallel previous research studies that have found DNA breaks after RF exposure. For a review of research on genotoxicity we also recommend Dr. Lai's "Evidence For Genotoxic Effects" in the Bioinitiative 2012 which shows that the majority of research studies have found an effect.
Please see below some examples of research that has found a neurotoxic effect after exposure to radiofrequency wireless radiation.
Research Studies:
- Conclusion: Exposure to 1800-2100 MHz radiation leads to damage and decrease of neurons in hippocampal region, which alters the learning and memory.
- The aim of this study was to investigate the effect of electromagnetic fields on BALB/c strain mice on their health, body weight, behavior characteristics, hematological parameters and histopathological findings in the brain. The mice of the experimental groups were exposed to electromagnetic waves by using Nokia 230 and Samsung 19300 Galaxy S III mobile phones situated at 2 cm from the cages. In the present study, it can be concluded that the exposure of mice to mobile phone radiation had an effect on the structure of the brain, behavior and body weight. The waves of mobile phones increased activity characteristics and changed some behavioral categories of mice and also decreased their body weight. Histopathological examination revealed mild edema of neutrophils and degeneration of some neurons and glial cells in the brains of experimental mice. The results of the present study showed that a using mobile phone had an influence on in vivo systems.
Poulletier de Gannes F, et al. "Effects of GSM and UMTS mobile telephony signals on neuron degeneration and blood-brain barrier permeation in the rat brain." Sci Rep 7.15496 (2017).
- "In the present work, BBB permeability in the whole rat brain increased significantly 50 days after repeated exposures: 3-fold for GSM and 2.4-fold for UMTS at 13 W/kg. A similar significant effect was seen in the whole brain with GSM-1800 at 0.26 W/kg. However, while the mean number of spots was quite similar at different BASAR levels, their distribution among the animals varied. For example, 20% of the 0.026 W/kg rats had between 4 and 5.5 spots, versus 45% of the 13 W/kg rats (data not shown). Thus, the effect was much stronger and consistent at 13 W/kg than at 0.026 W/kg or 0.26 W/kg. It is also noteworthy that the highest albumin levels were comparable to the highest background levels in cage-control rats (Fig. 3)."
Deniz, Omur Gulsum, et al. "Effects of short and long term electromagnetic fields exposure on the human hippocampus." Journal of Microscopy and Ultrastructure (2017). doi: 10.1016/j.jmau.2017.07.001.
- Analysis of the spectroscopic results revealed no significant difference in specific metabolites between the groups (p > 0.05). There was also no significant difference in terms of hippocampal volume between the groups (p > 0.05). In contrast, the results of the stroop and digit span (backward) neurocognitive tests of high exposure group for evaluating attention were significantly poorer from low exposure group (p < 0.05).
- "Based on these results, we conclude that a lack of attention and concentration may occur in subjects who talk on mobile phones for longer times, compared to those who use phones relatively less."
Altun, Gamze, et al. "Protective effects of melatonin and omega-3 on the hippocampus and the cerebellum of adult Wistar albino rats exposed to electromagnetic fields." Journal of Microscopy and Ultrastructure , 2017.
- Significant cell loss in the CA1 and CA2 regions of hippocampus were observed in the EMF compared to other groups (p < 0.01). In the CA3 region of the EMF + ω3, a significant cell increase was found compared to other groups (p < 0.01). Granular cell loss was observed in the dentate gyrus of the EMF compared to the Cont (p < 0.01). EMF + ω3 has more granular cells in the cerebellum than the Cont, EMF + Mel (p < 0.01). Significant Purkinje cell loss was found in the cerebellum of EMF group compared to the other (p < 0.01). EMF + Mel and EMF + ω3 showed the same protection compared to the Cont (p > 0.05).
- The passive avoidance test showed that entrance latency into the dark compartment was significantly shorter in the EMF (p < 0.05). Additionally, EMF had a higher serum enzyme activity than the other groups (p < 0.01).
- "In conclusion, our analyses confirm that EMF may lead to cellular damage in the hippocampus and the cerebellum, and that Mel and ω3 may have neuroprotective effects."
Kim, Ju Hwan, et al. "Long-term exposure to 835 MHz RF-EMF induces hyperactivity, autophagy and demyelination in the cortical neurons of mice." Scientific Reports, vol. 7, no. 41129, 2017.
- Induction of autophagy genes and production of proteins including LC3B-II and Beclin1 were increased and accumulation of autolysosome was observed in neuronal cell bodies. However, proapoptotic factor Bax was down-regulted in the cerebral cortex. Importantly, we found that RF-EMF exposure led to myelin sheath damage and mice displayed hyperactivity-like behaviour.
- "The data suggest that autophagy may act as a protective pathway for the neuronal cell bodies in the cerebral cortex during radiofrequency exposure. The observations that neuronal cell bodies remained structurally stable but demyelination was induced in cortical neurons following prolonged RF-EMF suggests a potential cause of neurological or neurobehavioural disorders."
Sharma, Archana, et al. "Ten gigahertz microwave radiation impairs spatial memory, enzymes activity, and histopathology of developing mice brain." Molecular and Cellular Biochemistry, 2017.
- Body weight result showed significant changes immediately after treatment, whereas non-significant changes were observed in mice attaining 6 weeks of age. Several other endpoints like brain weight, lipid peroxidation, glutathione, protein, catalase, and superoxide dismutase were also found significantly (p < 0.05) altered in mice whole brain. Moreover, statistically significant (p < 0.001) effect was investigated in spatial memory of the animals, in learning to locate the position of platform in Morris water maze test. Significant alteration in histopathological parameters (qualitative and quantitative) was also observed in CA1 region of the hippocampus, cerebral cortex, and ansiform lobule of cerebellum.
Pall, Martin L. "Microwave frequency electromagnetic fields (EMFs) produce widespread neuropsychiatric effects including depression." Journal of Chemical Neuroanatomy 75 (2016): 43-51.
doi: 10.1016/j.jchemneu.2015.08.001.
- Two U.S. government reports from the 1970s to 1980s provide evidence for many neuropsychiatric effects of non-thermal microwave EMFs, based on occupational exposure studies. 18 more recent epidemiological studies, provide substantial evidence that microwave EMFs from cell/mobile phone base stations, excessive cell/mobile phone usage and from wireless smart meters can each produce similar patterns of neuropsychiatric effects, with several of these studies showing clear dose–response relationships. Lesser evidence from 6 additional studies suggests that short wave, radio station, occupational and digital TV antenna exposures may produce similar neuropsychiatric effects.
- Among the more commonly reported changes are sleep disturbance/insomnia, headache, depression/depressive symptoms, fatigue/tiredness, dysesthesia, concentration/attention dysfunction, memory changes, dizziness, irritability, loss of appetite/body weight, restlessness/anxiety, nausea, skin burning/tingling/dermographism and EEG changes.
Wyde, Michael, et al. "Report of Partial findings from the National Toxicology Program Carcinogenesis Studies of Cell Phone Radiofrequency Radiation in Hsd: Sprague Dawley® SD rats (Whole Body Exposure)." bioRxiv, 055699, 2016. (National Toxicology Program Video Presentation that includes genotoxicity results June 2016)
- Increased incidence of gliomas – a rare, aggressive, and highly malignant brain cancer – as well as schwannomas (a rare tumor of the nerve sheath) of the heart were found in both sexes but reached statistical significance only in males.
- DNA damage was significantly increased in the frontal cortex of male mice from CDMA and GSM cell phone radiation, peripheral leukocytes of female mice from CDMA only, and the hippocampus of male rats from CDMA only.
- Link to the presentation of National Toxicology Program data on the genotoxicity of cell phone radiation in rats and mice at the annual meeting of the Environmental Mutagenesis and Genomics Society held in Raleigh, North Carolina from September 9-13, 2017.
Tang, Jun, et al. "Exposure to 900MHz electromagnetic fields activates the mkp-1/ERK pathway and causes blood-brain barrier damage and cognitive impairment in rats." Brain Research, vol. 1601, 2015, pp. 92-101.
- Researchers found that the frequency of crossing platforms and the percentage of time spent in the target quadrant were lower in rats exposed to EMF for 28 days than in rats exposed to EMF for 14 days and unexposed rats. Moreover, 28 days of EMF exposure induced cellular edema and neuronal cell organelle degeneration in the rat. In addition, damaged BBB permeability, which resulted in albumin and HO-1 extravasation were observed in the hippocampus and cortex.
Dasdag et al. "Effects Of 2.4 Ghz Radiofrequency Radiation Emitted From Wi-Fi Equipment On microRna Expression In Brain Tissue." International Journal of Radiation Biology, vol. 16, 2015, pp. 1-26.
- The significant effects on microRNAs observed in this study were found from Wi-Fi exposure that was well below the legal limit. CONCLUSION: Long term exposure of 2.4 GHz RF may lead to adverse effects such as neurodegenerative brain diseases originated from the alteration of some miRNAs expression.
Roggeveen S, et al. EEG changes due to experimentally induced 3G mobile phone radiation. PLoS One, vol. 10, no. 6, 2015.
- Significant radiation effects were found for the alpha, slowbeta, fastbeta, and gamma bands. When analyzed separately, ear location of the phone was associated with significant results, while chest placement was not.
- The results support the notion that EEG alterations are associated with mobile phone usage and that the effect is dependent on site of placement. Further studies are required to demonstrate the physiological relevance of these findings.
Zarei et al. A Challenging Issue in the Etiology of Speech Problems: The Effect of Maternal Exposure to Electromagnetic Fields on Speech Problems in the Offspring. Journal of Biomedical and Physical Engineering, vol. 5, no. 3, 2015, pp. 151-4.
- Researchers found a significant association between either the call time (P=0.002) or history of mobile phone use (months used) and speech problems in the offspring (P=0.003). However, other exposures had no effect on the occurrence of speech problems.
Bin Lv, et al. The alteration of spontaneous low frequency oscillations caused by acute electromagnetic fields exposure. Clinical Neurophysiology, vol. 125, no. 2, 2014, pp. 277-86.
- Researchers found a decreased ALFF value around in left superior temporal gyrus, left middle temporal gyrus, right superior temporal gyrus, right medial frontal gyrus and right paracentral lobule after the real exposure. And the decreased fALFF value was also detected in right medial frontal gyrus and right paracentral lobule.
- The study provided the evidences that 30min LTE RF-EMF exposure modulated the spontaneous low frequency fluctuations in some brain regions.
Júnior, L.C., et al. Behavior and memory evaluation of Wistar rats exposed to 1·8 GHz radiofrequency electromagnetic radiation. Neurological Research, vol. 36, no. 1, 2014.
- Frequency of rearing was increased by 193.3%, revealing an increase in exploratory activity of the animals, which is also related to anxiety, depression, and stressful behavior.
- "Our data corroborate that reported by Narayanan et al., 21 who showed in 2012 that animals exposed to mobile phone radiation had an increased frequency of rearing."
Qiao S, et al. Reduction of Phosphorylated Synapsin I (Ser-553) Leads to Spatial Memory Impairment by Attenuating GABA Release after Microwave Exposure in Wistar Rats. PLoS ONE, vol. 9, no. 4, 2014.
- In the rat experiments, there was a decrease in spatial memory performance after microwave exposure. Both microwave exposure and p-Syn I silencing reduced GABA release and maximal reduction was found for the combination of the two, indicating a synergetic effect.
- p-Syn I (ser-553) was found to play a key role in the impaired GABA release and cognitive dysfunction that was induced by microwave exposure.
Razavinasab M, K. Moazzami and M. Shabani. Maternal mobile phone exposure alters intrinsic electrophysiological properties of CA1 pyramidal neurons in rat offspring. Toxicology and Industrial Health, vol. 30, no. 2, 2014, pp. 101-96.
- The results of the passive avoidance and Morris water maze assessment of learning and memory performance showed that phone exposure significantly altered learning acquisition and memory retention in male and female rats compared with the control rats.
- "Our results suggest that exposure to mobile phones adversely affects the cognitive performance of both female and male offspring rats using behavioral and electrophysiological techniques."
Redmayne M, Johansson O. Could myelin damage from radiofrequency electromagnetic field exposure help explain the functional impairment electrohypersensitivity? A review of the evidence. Journal of Toxicology and Environmental Health, vol. 17, no. 5, 2014, pp. 247-58.
- Overall, evidence from in vivo and in vitro and epidemiological studies suggests an association between RF-EMF exposure and either myelin deterioration or a direct impact on neuronal conduction, which may account for many electrohypersensitivity symptoms. The most vulnerable are likely to be those in utero through to at least mid-teen years, as well as ill and elderly individuals.
Saikhedkar N, et al. Effects of mobile phone radiation (900 MHz radiofrequency) on structure and functions of rat brain. Neurological Research, vol. 2, no. 6, 2014, pp. 2499-504.
- "Our findings indicate extensive neurodegeneration on exposure to radio waves. Increased production of reactive oxygen species due to exhaustion of enzymatic and non-enzymatic antioxidants and increased lipid peroxidation are indicating extensive neurodegeneration in selective areas of CA1, CA3, DG, and cerebral cortex. This extensive neuronal damage results in alterations in behavior related to memory and learning."
Jing J, et al. "The influence of microwave radiation from cellular phone on fetal rat brain. Electromagnetic Biology and Medicine, vol. 31, no. 1, 2012, pp. 57-66.
- Significant content differences were found in superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), noradrenaline (NE), dopamine (DA) after fetal brains were assayed.
- "Through this study, we concluded that receiving a certain period of microwave radiation from cellular phones during pregnancy has certain harm on fetal rat brains."
Sirav B, and N. Seyhan. Effects of radiofrequency radiation exposure on blood-brain barrier permeability in male and female rats.Electromagnetic Biology and Medicine, vol. 30, no. 4, 2011, pp. 253-60.
- A significant increase in albumin was found in the brains of the RF-exposed male rats when compared to sham-exposed male brains.
- Radio frequency radiation "at levels below the international limits can affect the vascular permeability in the brain of male rats. The possible risk of RFR exposure in humans is a major concern for the society."
Volkow, N.D., et al. Effects of cell phone radiofrequency signal exposure on brain glucose metabolism. Journal of the American Medical Association, vol. 305, no. 8, 2011, pp. 808-13.
- In healthy participants and compared with no exposure, 50-minute cell phone exposure was associated with increased brain glucose metabolism in the region closest to the antenna.
Maskey, Dhiraj, et al. "Effect of 835 MHz radiofrequency radiation exposure on calcium binding proteins in the hippocampus of the mouse brain."Brain Research, no. 1313, 2010, pp. 232-41.
- Body weights did not change significantly. CB immunoreactivity (IR) displayed moderate staining of cells in the cornu ammonis (CA) areas and prominently stained granule cells. CR IR revealed prominently stained pyramidal cells with dendrites running perpendicularly in the CA area. Exposure for 1 month produced almost complete loss of pyramidal cells in the CA1 area.
- CaBP differences could cause changes in cellular Ca(2+)levels, which could have deleterious effect on normal hippocampal functions concerned with neuronal connectivity and integration.
Nittby H, et al. Effects of microwave radiation upon the mammalian blood-brain barrier. European Journal of Oncology, vol. 5, 2010, pp. 333-55.
- EMF radiation leads to increased permeability of the Blood Brain Barrier (BBB) at non-thermal exposure levels.Damaging effects from radiofrequency EMF upon neurons has been shown after 28 days and 50 days.
- "The human BBB is very similar to the rodent BBB… it is our sincere belief, that it is more probable than unlikely, that non-thermal EMF from mobile phones and base stations do have effects upon the human brain.
Sonmez, O.F., et al. "Purkinje cell number decreases in the adult female rat cerebellum following exposure to 900 MHz electromagnetic field."Brain Research, vol. 1356, 2010, pp. 95-101.
- Results showed that the total number of Purkinje cells in the cerebellum of the EMFG was significantly lower than those of CG (p< 0.004) and SG (p< 0.002). In addition, there was no significant difference at the 0.05 level between the rats' body and brain weights in the EMFG and CG or SG. Therefore, it is suggested that long duration exposure to 900 MHz EMF leads to decreases of Purkinje cell numbers in the female rat cerebellum
Bas, O., et al. "900 MHz electromagnetic field exposure affects qualitative and quantitative features of hippocampal pyramidal cells in adult rat." Brain Research, no. 1265, 2009, pp. 178–85.
- A statistically significant decrease in the pyramidal cells of the hippocampus and an increase in dark cells.
Bas O, et al. Chronic prenatal exposure to the 900 megahertz electromagnetic field induces pyramidal cell loss in the hippocampus of newborn rats. Toxicology and Industrial Health, vol. 25, 2009, pp. 377–84.
- Results: A significant reduction in the total number of pyramidal cells in the cornu ammonis of the hippocampus, which involves short-term memory and learning.
- Sixteen-week old rats are comparable to the age of human teenagers.
Naziroğlu M. and Gumral. Modulator effects of L-carnitine and selenium on wireless devices (2.45 GHz)-induced oxidative stress and electroencephalography records in brain of rat. International Journal of Radiation Biology, vol. 85, no. 8, 2009, pp. 680-9.
- Rats exposed to 2.45 GHz 60 min/day for 28 days had lower cortex brain vitamin A (p < 0.05), vitamin C (p < 0.01) and vitamin E (p < 0.05) concentrations.
Odaci E, O. Bas and S. Kaplan. Effects of prenatal exposure to a 900 megahertz electromagnetic field on the dentate gyrus of rats: a stereological and histopathological study. Brain Research, no. 1238, 2008, 224–9.
- Prenatal exposure caused a progressive postnatal decline in the number of granule cells of dentate gyrus of the hippocampus of offspring.
Leszczynski, Dariusz, et al. "Non‐thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: Molecular mechanism for cancer‐and blood‐brain barrier‐related effects." Differentiation, vol. 70, no. 2‐3, 2002, pp. 120-9.
- Changes in the overall pattern of protein phosphorylation suggest that mobile phone radiation activates a variety of cellular signal transduction pathways, among them the hsp27/p38MAPK stress response pathway. Based on the known functions of hsp27, we put forward the hypothesis that mobile phone radiation-induced activation of hsp27 may (i) facilitate the development of brain cancer by inhibiting the cytochrome c/caspase-3 apoptotic pathway and (ii) cause an increase in bloodbrain barrier permeability through stabilization of endothelial cell stress fibers.
- "We postulate that these events, when occurring repeatedly over a long period of time, might become a health hazard because of the possible accumulation of brain tissue damage. Furthermore, our hypothesis suggests that other brain damaging factors may co-participate in mobile phone radiation-induced effects."
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<p><a href="https://vimeo.com/132987053″>VIDEO: Dr. Suleyman Kaplan addresses Commonwealth Club of California, June 22, 2015</a> from <a href="https://vimeo.com/electromagnetic">ElectromagneticHealth.Org</a> on <a href="https://vimeo.com">Vimeo</a>.</p>


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MERSEYSIDE plastics firm Colloids is set to complete a #3m investment at its Knowsley plant, consolidating its position in the global plastics market.
The firm is putting the finishing touches on a 22,500 sq ft development which will see a doubling of manufacturing capacity at its site on the Kirkby Bank Industrial Estate.
Colloids, which manufactures masterbatches - the raw pellets of colouring and additives used in the production of plastics - is to close its factories in Runcorn and Widnes due to spacial limitations.
A recently completed recruitment drive will see staffing levels at the new plant boosted to 85.
In addition to the expansion in production facilities, a new research and development lab has been constructed, housing state-of-the-art analytical equipment.
An 80t lock Demag injection moulding machine has been installed, to help new product development.
John Cavanagh, operations manager, said: "A great deal of effort has been put into the design of the plant to ensure manufacturing technology of the highest specification, and working conditions of the highest category for our employees."
The site is due to be fully operational late next month, with annual production of masterbatch expected to rise to 30,000 tonnes.


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Neoplastic Diseases
Methotrexate is indicated in the treatment of gestational choriocarcinoma, chorioadenoma destruens and hydatidiform mole.
In acute lymphocytic leukemia, methotrexate is indicated in the prophylaxis of meningeal leukemia and is used in maintenance therapy in combination with other chemotherapeutic agents. Methotrexate is also indicated in the treatment of meningeal leukemia.
Methotrexate is used alone or in combination with other anticancer agents in the treatment of breast cancer, epidermoid cancers of the head and neck, advanced mycosis fungoides (cutaneous T cell lymphoma), and lung cancer, particularly squamous cell and small cell types. Methotrexate is also used in combination with other chemotherapeutic agents in the treatment of advanced stage non-Hodgkin's lymphomas.
Methotrexate in high doses followed by leucovorin rescue in combination with other chemotherapeutic agents is effective in prolonging relapse-free survival in patients with non-metastatic osteosarcoma who have undergone surgical resection or amputation for the primary tumor.
Methotrexate is indicated in the symptomatic control of severe, recalcitrant, disabling psoriasis that is not adequately responsive to other forms of therapy, but only when the diagnosis has been established, as by biopsy and/or after dermatologic consultation. It is important to ensure that a psoriasis "flare" is not due to an undiagnosed concomitant disease affecting immune responses.
Rheumatoid Arthritis including Polyarticular-Course Juvenile Rheumatoid Arthritis
Methotrexate is indicated in the management of selected adults with severe, active rheumatoid arthritis (ACR criteria), or children with active polyarticular-course juvenile rheumatoid arthritis, who have had an insufficient therapeutic response to, or are intolerant of, an adequate trial of first-line therapy including full dose non-steroidal anti-inflammatory agents (NSAIDs).
Aspirin, (NSAIDs), and/or low dose steroids may be continued, although the possibility of increased toxicity with concomitant use of NSAIDs including salicylates has not been fully explored. (See PRECAUTIONS, Drug Interactions.) Steroids may be reduced gradually in patients who respond to methotrexate. Combined use of methotrexate with gold, penicillamine, hydroxychloroquine, sulfasalazine, or cytotoxic agents, has not been studied and may increase the incidence of adverse effects. Rest and physiotherapy as indicated should be continued.