text:
almost 3 years ago
And the winner is...
The judges have weighed in, and our community has voted! Go to the RingCentral Bots Challenge gallery to congratulate the winners and check out all the enterprise bots.
Even though the competition is over, you don't have to stop coding. Update your portfolio to inform your followers about new projects and get feedback from fellow hackers. Check out upcoming in-person and online hackathons and build something amazing.
We're here to help. If you have any questions about the hackathon, post on the discussion forum or email firstname.lastname@example.com and we'll respond as soon as we can.
almost 3 years ago
One week to go–the deadline is almost here!
Time's almost up. There's only one week left to submit your bot to the RingCentral Bots Challenge. Submissions are due January 8 before 5pm ET. Find out what time that is in your city.
If you have any questions about the hackathon, please post on the discussion forum.
almost 3 years ago
Three weeks left—start your submission now!
There's are three weeks remaining in the RingCentral Bots Challenge! Submissions are due January 8, 2018 before 5pm ET. Find out what time that is in your city.
If you haven't started a submission yet, please do so now. Starting a submission is a good way to make sure that your app meets the requirements. Remember: once you submit a project, you can keep editing it as needed at any time prior to the submission deadline. (Check out our submission form tutorial if you need some help.)
Don't forget about the video showing your app—it's required, and…
almost 3 years ago
Making a great submission video
We're halfway through the RingCentral Bots Challenge! We know you're focused on preparing your Glip chatbot for submission, but don't forget about your video. It's often the first (and sometimes only!) thing that judges review.
A good video tells the story behind your submission, providing a clear and concise explanation of what your app is and does. Check out our video-making best practices and follow these tips:
- Establish your elevator pitch. In the first few seconds of your video, explain how your app improves business workflows. You can get into the details of how it works later on in the…
about 3 years ago
Quick-start guide
Thanks for joining the RingCentral Bots Challenge! You're officially registered now, and we'll be sending you regular updates throughout the competition.
Here's how to prepare yourself to build a bot using the Glip bot framework and other RingCentral communication APIs. Remember: Submissions are due January 8, 2018, at 5pm ET.
- Sign up for a developer account. Head over to developer.ringcentral.com to sign up for a free developer account and request an API key. Then follow the instructions here to create a RingCentral application.
- Introducte yourself, find a teammate and collaborate with other participants.
- Join the Glip chat…


text:
Bunk Room
The Club provides comfortable bunkroom accommodation in central London. Members can stay in our bunkroom for free from Monday to Thursday when travelllng on behalf of the Club or on mountaineering business.
Four bunk beds are available for use by members. Please bring a sleeping bag and towel.
To arrange your booking, please contact the Office Manager at the AC. Keys can be collected during office hours.
(Please note that the bunkroom at the Club House is a benefit strictly for the use of Alpine Club members)
Lecture Theatre Rental
The ground floor Lecture Theatre seats up to 60 people and is quiet, spacious and comfortable.
It is the perfect venue for daytime meetings, lectures, presentations and events and is available at a very competitive rate of £250 per day excl VAT.

subset: commoncrawl


text:
I write about a variety of subjects, often seemingly unrelated. My experience, and the experience of all of us if we choose to look at it, shows that this is not the case. In fact, everything is related. I love to read. Shakespeare, History, sociology, philosophy, religion, Spirituality, non-fiction, horror, romance, fairy tales, classics... there … Continue reading The Concept Of Everything
Tag: History
Happy Samhain
I try not to immerse myself in political, or social issues too often. There is too much emotion attached, and not enough information and truth being taken into consideration. Today, I'm going to make an exception to that rule. There is an issue that has been being pushed over the last several years, and this … Continue reading Happy Samhain


text:
PharmaVentures' Client Sanofi Wins Scrip 'Outsourcing Deal of the Year Award'
12 Jan, 2012, 08:30 GMT
OXFORD, English, January 12, 2012 /PRNewswire/ --
PharmaVentures announced today that it was delighted to play an advisory role in the Sanofi - Covance deal which won Scrip's 'Outsourcing Deal of the Year 2011'.
The judges described the deal as 'impressive' as it was "one the largest and most comprehensive R&D alliances in the history of the pharmaceutical and CRO industry".Under the terms of the agreement, Sanofi retains access to some of the capabilities that were divested to Covance as part of a long-term strategic alliance. Covance will provide Sanofi with an up to 10-year sole source relationship for central lab services.
Kevin Bottomley, Head of Transactions at PharmaVentures who was lead advisor to Sanofi on the deal said: "This is a great recognition for Sanofi as this was a ground-breaking deal which ultimately supports both its overall strategic intent."
Fintan Walton, Chief Executive of PharmaVentures said: "Deal making has become both more complex and more sophisticated. This Scrip Award recognises how PharmaVentures' clients are reaching new heights in deal making. We are delighted to be advisors to this award winning deal."
Over the years PharmaVentures has built considerable experience in the M&A field including divestments of manufacturing and R&D businesses.
Note to Editors
If you wish to write an article, please contact us for any further information you require.
About PharmaVentures
PharmaVentures (http://www.pharmaventures.com) is an international healthcare advisory group providing leadership in all aspects of deals and alliances, from strategy formulations to implementation. The company occupies a special position in the global marketplace because of our track record of successful outcomes, resulting from our unique insight into the world of deal making, our internationally recognised analytical and valuation capabilities, our own proprietary deal making database PharmaDeals®(http://www.pharmadeals.net), containing over 42,000 deal records, and our extensive business relationship network and our outstanding success in M&A transactions.
Our Services Cover:
- Valuation (for licensing, acquisitions, divestments, fund raising & expert testimonies)
- Licensing (In and Out licensing)
- M&A (Companies & Assets)
- Strategy (commercialisation, deal strategy, due diligence, market entry)
- Expert Testimony (Patent Infringement, Deal Disagreements, Taxation, Determining Damages)
Now in its 20th year, PharmaVentures is based in Oxford, UK, and employs over 30 people.
PharmaDeals® and PharmaVentures® are registered Trade Marks of PharmaVentures Ltd.
For further information, contact:
Kevin Bottomley
Head of Transactions
+44 1865-332700
SOURCE PharmaVentures Ltd


text:
Stanley Deno
Dr. Deno is well-known for his work focusing on the failure of students to develop basic skills in reading, writing, and arithmetic, but is best known for his research leading to the development of Curriculum-based Measurement (CBM) progress monitoring procedures and their use in the Response-to Intervention (RTI) model. CBM procedures are now widely used in both special and general education to monitor basic skills growth, to identify students at risk of learning difficulty, to evaluate efforts to prevent and remediate low achievement, to aid in making instructional decisions and to predict performance on high stakes tests.
Contributor Directory


text:
This lesson is part of a series of video language classes which will build a solid foundation for learning how to speak Arabic. The instructor in these instructional videos is a native Arabic speaker who started making his own teaching tutorials in an effort to demonstrate clearly how the language is really spoken back in his home in the Middle East. In this video segment, the instructor will focus on the Arabic letter dal the-al.
Want to master Microsoft Excel and take your work-from-home job prospects to the next level? Jump-start your career with our Premium A-to-Z Microsoft Excel Training Bundle from the new Gadget Hacks Shop and get lifetime access to more than 40 hours of Basic to Advanced instruction on functions, formula, tools, and more.


text:
It was only on Wednesday that we received a whole batch of new images from Wes Craven's upcoming horror sequel, Scream 4, but apparently Dimension Films is really excited to promote it. Today not only do we get high res versions of the Wednesday stills, but two new ones and a television spot.
The first new image shows off everyone's favorite Woodsboro police officer, Dewey (David Arquette), holding a gun, but the real attraction here is the bloodspattered, knife-wielding Ghostface. If these past few days have proven anything, it's that Scream 4 won't be lacking in blood.
Still looks good to me. I know I'm excited and ready for this movie.
I can't wait to see this. It really takes me back. I loved the first ones and this seems to return to that well. This should be a fun movie.
Does anyone here know how to fix my computer so it will play videos in these players? it plays the ads but it never plays the actual videos.


text:
The Osgrid is an independent open-source virtual world with an implemented dynamic hypergrid concept, allowing users to jump from one grid to another. Now you must ask: "Pew, what kind of sorcery is this?" It's simple. There are hundreds of open simulator-based virtual worlds and the Osgrid is one of them. With a dynamic hypergrid feature, users can teleport from the NetflixandChill Grid to the GameofThrones Grid instead of being limited to Second Life's single grid - a list of OpenSimulator grids is available HERE.
With all this potential, is no surprise to see several role-play communities in this simulator however, I was amazed by the land growth and improvement since my last visit to the grid. Here you can find the Counter Earth Grid, a massive grid for Gorean role-players, which is currently looking for more people and vendors to become part of the family. Some of the cities in the Counter Earth Grid are stunning and they are as good as any of the Gorean sims in Second Life. Saying that OpenSim is 10 years behind Second Life is a total misconception - users have easy access to the best mesh products. There are, of course, technical pros and cons.
- Free Content: Osgrid does not have a working currency system. All content is free and there are hundreds of free shops. Users can purchase items by using a third party vendor like https://www.kitely.com/market -which is basically the marketplace for all the OpenSimulator grids;
- Bigger Sims: Sims are 4 times larger than Second Life sims;
- Cheaper Sims: A Counter Earth sim runs $20 per month with 20,000 prims. You can have 10,000 more prims for an additional $10;
- The Counter Earth Grid is active: The community is small but there are community events and you can find players in the regions;
- The Counter Earth Grid has several Gorean sims that matches the map of Gor, and rules are simple;
- Use of Voice is Encouraged: OpenSim users prefer voice to text;
- The Counter Earth Grid has a combat meter;
- Hypergriding;
- Stable Regions;
- OpenSim is Occulus Rift compatible;
- Great mesh products are available for free;
- There are other role-play communities in the grid: Scifi, GoT, Urban, Hogwarts, Medieval, you name it!
- Small Community: Osgrid had little growth over the years - I personally think being part of small community can make the game more enjoyable which might not be the case for many of you;
- Hypergriding Can Be Difficult: Players can be surely excited of jumping from grid to grid but you must understand how to get there. Forget about using the search button. Instead, you must use www.opensimworld.com for your searches. Once you find the sim you are looking for, copy the IP address or the grid's domain and paste it to your viewer's map. You can also open the landmarks directly from the website if you use Firestorm as your viewer. I would love to see this feature improved to something more user-friendly. I personally think this teleporting system it's a little messy and hard to understand at first.
Check the following links for detailed information on how to join the Osgrid and the Counter Earth Grid.


text:
Is it a plane? Is it a bird? No, it's Longtail!
What is Longtail?
No, it isn't a type of newt or lizard, or any of those little critters for that matter! Longtail describes how niche marketing works on the internet. For example, shops that sell products like DVDs and CDs can only afford to carry the most popular releases. More people would buy said popular products, so the company is able to afford their overhead expenses. However, by taking geographic location out of the equation, the internet changes everything.
Definitely not a newt
So now that we've established that Longtail isn't a type of reptile, why should you use it? Hang in there, we're getting to it! The idea is that if you create content and optimise the keywords that aren't as popular as other terms, you will encounter less competition for the terms and so will ultimately get more page views. With fewer results to choose from, it increases the likelihood of a potential client finding your site! So instead of focusing entirely on optimising your page for one or two really popular trends, go for Longtail results, meaning a smaller competition and still plenty of room for popularity and profit.
Turquoise peep-toes
In short, Longtail keywords are those phrases that don't have as large a search volume as the more popular terms out there. For example, I want to buy a pair of shoes. I want some turquoise-coloured shoes. So, I go ahead and type into my Google search bar, 'turquoise shoes'. Bingo! 42,200,000 results. Oh dear, that's a lot of shoes to look through. So I get more specific. I want these shoes to be heels and I'd like them to be peep-toes, too. This brings my options down to 2,050,000 web pages to choose from. Let's narrow down that search again, shall we. I've decided that I'd like these shoes to be suede and have an exact heel-height of four inches. We're now down to 71,500 results. Not bad. Instead of typing in the single phrase, 'turquoise shoes' and getting specific, I've significantly narrowed down my selection. Typing 'suede turquoise peep-toes 4 inch heels' is by far more effective than my original, 'turquoise shoes'. Get it now? Of course you do! The longtail keywords actually makes up 70% of the overall searches performed, compared to just 30% for the "popular" search terms!
So, if your business depends on potential customers/clients finding you through a Google search, the Longtail technique is for you. So rather than focus all your efforts on making your webpage the most popular, concentrate on making lots of pages that serve niche markets.
Out with the old…
So, you've identified your Longtail phrases, now what? Well, you need to make sure that your site is optimised for them. You can do this by updating old content, or creating new – or both of course!
Creating is of course always good because it means you'll have more content on your website, meaning more pages are available to be found in a search. Remember, you're optimising Longtail keywords now, so get specific! So, instead of using the phrase, 'long-tailed lizard', you need to include the keywords, 'Asian' and 'grass', giving you the 'Asian Long-tailed grass lizard'. Much more specific and a lot more effective!
You might be able to say no to us, but how could you ignore this little guy? Listen to the Asian long-tailed grass lizard. Get long-winded, go Longtail!


text:
Roads set to be 'twice as busy' this Easter
A perfect storm of rail engineering works, holiday traffic and good weather will see journey times on some roads double.
INRIX, the traffic information provider, estimates worst affected hotspots will be twice as busy as non-holiday times.
Half hour journeys around the west of the M25 near Heathrow Airport are expected to take and hour, while delays on the M4 heading out of London towards the West Country of up to an hour.
This year's busiest periods will be on Thursday 17th April with traffic levels barely dropping for the entire day.
Meanwhile, major railway engineering projects on the East and West Coast Mainlines and the Great Western Mainline this Easter weekend will result in an increase in vehicles on the roads causing the following delays:
Up to a one-hour delay on a typical journey from London to Leeds via the M1
At least 30 minutes added to a typical journey along the M4 from London to Bristol
Up to a one-hour delay on a typical journey from London to Manchester using the M1 and M6
Read: Major disruption set to hit London stations over Easter
Best and worst travel times
Thursday April 17th
Best time: Between 10am and 12pm Worst time: Between 4pm and 5pm
Friday April 18th
Best time: Before 10am and after 5pm Worst time: 12pm
Monday April 21st
Best time: Before 10am and after 6pm
Worst time: 11am
Top 10 traffic hotspots with alternative routes in brackets
M4 between Hants. & West Country 60 minutes (M3 and A303)
M25 between J7 and J21A 40 minutes (Non-M'way routes)
A303 Amesbury 30 minutes from A36 to A338 (None)
M55 between Preston and Blackpool 30 minutes (None)
A456 between M5 and Kidderminster 30 minutes (None)
M4 between London and Reading 25 minutes (M3 and A33)
M25 J5 Sevenoaks 20 minutes from J3 to J7 (M26 and M20)
M1 between J1 and Luton Airport 15 minutes (A1(M) and A505)
M6 between J8 and J10A 15 minutes (J6 to J11 M6 Toll)
M1 between J21 and J28 15 minutes (A6)
INRIX Traffic Analyst Chris Lambert says the increased road use is a good sign the economy is on the up.
"As much as traffic frustrates those on the road, increasing congestion is a sign that the economy is recovering as businesses deliver more goods, new car sales increase and more people use their car," he added.
"More Brits going on holiday combined with extensive engineering works on the rail network is going to result in exceptionally heavy congestion this Easter weekend."
RAC spokesman Simon Williams, said: "With the hint of better weather ahead people will be heading to the coast and countryside to make the most of the Easter break, which will create all kinds of traffic issues.
"With many schools going back on Tuesday 22nd April, we are expecting a busy bank holiday Monday rush home as people take to the roads en masse.
"We would advise drivers to allow plenty of time for their journeys, and to take note of INRIX's alternative routes for the worst congested areas over the Easter period, to avoid getting stuck in the inevitable delays."


text:
Hey, remember those cranky folks who couldn't get their Super Bowl seats? Remember how they're suing, and how $5 million wouldn't be enough in remuneration?
Well, even if you don't, meet them again, because they decided to ask for more money—this time, it's lost income.
Super Bowl ticket-holders displaced during the seating fiasco at Cowboys Stadium in February said Tuesday in a court filing they should be compensated for lost income on top of the other expenses they incurred.
Ticket holders who lost their seats or had obstructed views "at a very minimum" should be paid for lost income suffered as a result of traveling to suburban Arlington, according to a document filed in response to a motion by the Dallas Cowboys and the NFL seeking to dismiss the class action lawsuit.
Call us cold-hearted, but if you decide to go to the Super Bowl, aren't you forfeiting that income in the first place? At worst, you got a vacation in Arlington with slightly poorer seats—and the NFL reimbursed fans for all of that: travel, hotel, meals, tickets. Not a bad deal.
Then again, you know, if I had known I would be watching the Super Bowl from the field level club, I probably woulda stayed home and created a social network that woulda made Facebook look like Friendster. Pay me, Roger!
Displaced fans seeking lost income [ESPN Dallas]


text:
Are you a beginner who is planning to join GYM? Well. You should be aware about a few points that you should consider while going there. Have a look on bodybuilding mistakes that we normally do in the gym:
Mistake No 1: Never put the Weights Back
Surely, it would be most irritating for anyone and a bad gym manner. After using gym equipments, make sure you put all the weights and equipments back at their places to enable other find them easily.
Mistake 2: Letting Your Ego Lift
It is important to leave your ego out the door. Never put too much weight or make use of the improper form, to amaze opposite sex, friends or more professional guys. Possibly, you think that you look cool. However, the women dont care and the expert guy is surely laughing on you. It can result in injury. So, take care of everything.
Mistake 3: Not Applying Collars/Clips
The most useful and dangerous form of training is completely free weights. Moreover, for a novice is even difficult particularly for exercises such as squat, barbell bench press and even barbell military press. Your leading side might take above and you might get one side up while the other is stressed, creating a hill where weights can simply slide off.
Mistake 4: Always Wipe Your Sweat Away
If you are serious for the gym training, never allow sweat to appear on your face. You need to spend a few second and does not make you appear such as a douche bag; it also stops broaden of germs.
Mistake 5: More Is Better
Keep in mind that more is not always better, it is important to raise the weight or even repeat every workout. But rather than focusing on the quantity of exercise, focus on the quality. Listen to your body and do not try to push your limits.
Mistake 6: Not Following Right Form of exercises
Not using the right workout posture will result in an injury or you won't gain something, both are simply no good for bodybuilding. Always take help from your coach or a personal trainer. Starting few workouts, making use of the light weight is quite helpful when you consider learning the right form.
Mistake 7: Not working on Plan
Before joining the gym, it is important to have a plan on what body part you are going to work, what exercises you will carry, what should be the measure of reps and sets. You have to plan in advance and then execute it in order to achieve the desired results.
Mistake 8: Not Asking For Advice
No doubt, Gym can be extremely risky place and many people recognize that, particularly the practiced guys. If you require somebody to notice you or you require somebody to check your form do not be scared to ask. The most horrible thing is somebody will inform you "no" but will assist. You should be polite. It is not difficult.
The above 8 mistakes should be avoided and if completely will assist you reach your motives, avoid any internal injury and make your gym training productive and enjoyable.


text:
The UP Asian Center will host a free lecture and exhibit on "Colors of Diversity: The Ethnic Dresses of Iran" from 11 to 13 October 2017 at the UP Asian Center, Quezon City. The exhibit will open at 12 noon and will be followed by the lecture. The event is free and open to the public, but participants are encouraged to sign up.
Although the majority of Iranians are Persian, Iran has a diverse population of ethnic groups, each with their own language, tradition, and clothes—all of which shape the country's rich cultural tapestry. Women's clothes are strong identifiers of regional and ethnic groups. People can differentiate which groups they belong to based on the colorful fabrics, embroidered patterns, decorative jewelry, and style of the traditional dresses of Iran. The exhibit will showcase the collection of Ms. Shahin Ebrahimzadeh Pezeshki, famous artist and expert in traditional Iranian dressmaking. Her collection features traditional dresses from different cities of Iran.
In her lecture, Ms. Pezeshki will talk about her work—the art and culture behind it—and provide some overview on ethnic dresses vis-a-vis Iranian society.
Ms. Shahin Ebrahimzadeh Pezeshki is an artist and researcher in the Iranian Art of Traditional sewing. She is the author of "Seven Standards in Teaching Needle Sewing and Classic Decoration of Today's Modern Dresses," and is an expert on Sormeh sewing, needle sewing, Iranian silk sewing, and the modern methods of sewing with native designs. Her work has travelled the world over, exhibited in Indonesia, Kazakhstan, Kyrgyzstan, Turkmenistan, Pakistan, Bangladesh, Turkey, Kenya, Spain, England, and Romania.
This free exhibit is organized by the UP Asian Center; The Cultural Center, Islamic Republic of Iran; and the Philippine-Iran Cultural and Scientific Society (PICCS).
INQUIRIES, VENUE And VICINITY MAP
The Asian Center offers M.A. degrees in Asian Studies with four fields of specialization: Northeast Asia, Southeast Asia, South Asia, and West Asia. The Center also has an M.A. program in Philippine Studies that allows students to major in Philippine society and culture, Philippine foreign relations, or Philippine development studies. The Center offers a Ph.D. program in Philippine Studies in conjunction with the College of Arts and Letters and the College of Social Sciences and Philosophy. For an overview of these graduate programs, click here. The Asian Center also publishes Asian Studies: Journal of Critical Perspectives on Asia, the latest issue of which can be downloaded at the journal's website. For other news and upcoming events at the Asian Center, click here.


text:
Microorganisms that use sulfate as a terminal electron acceptor for anaerobic respiration play a central role in the global sulfur cycle. Here, we report the results of comparative sequence analysis of dissimilatory sulfite reductase (DSR) genes from closely and distantly related sulfate-reducing organisms to infer the evolutionary history of DSR. A 1.9-kb DNA region encoding most of the α and β subunits of DSR could be recovered only from organisms capable of dissimilatory sulfate reduction with a PCR primer set targeting highly conserved regions in these genes. All DNA sequences obtained were highly similar to one another (49 to 89% identity), and their inferred evolutionary relationships were nearly identical to those inferred on the basis of 16S rRNA. We conclude that the high similarity of bacterial and archaeal DSRs reflects their common origin from a conserved DSR. This ancestral DSR was either present before the split between the domains Bacteria, Archaea, andEucarya or laterally transferred betweenBacteria and Archaea soon after domain divergence. Thus, if the physiological role of the DSR was constant over time, then early ancestors of Bacteria andArchaea already possessed a key enzyme of sulfate and sulfite respiration.
The ability to use sulfate as a terminal electron acceptor is characteristic of several bacterial lineages and one thermophilic genus of Archaea. In these prokaryotes, the enzyme dissimilatory sulfite reductase (DSR) catalyzes the six-electron reduction of (bi)sulfite to sulfide, which is the central energy-conserving step of sulfate respiration (25). One archaeal (Archaeoglobus fulgidus) and four bacterial DSRs have so far been characterized by enzyme properties (8, 14, 21, 22, 36). Characterized bacterial enzymes and typical sources include desulfoviridin (e.g., Desulfovibrio vulgaris), desulforubidin (e.g., Desulfovibrio desulfuricans Norway), P582 (e.g., Desulfotomaculum ruminis), and desulfofuscidin (e.g., Thermodesulfovibrio yellowstonii). Although they differ in absorption spectra, electrophoretic mobilities, and redox properties, all characterized bacterial enzymes have an α2β2 structure or an α2β2γ2 structure (3, 8, 27) and possess iron-sulfur clusters and siroheme prosthetic groups. Gene sequences were previously determined for the DSR genes of A. fulgidus and Desulfovibrio vulgaris (8, 20) and were used to assign them to a redox enzyme superfamily characterized by a repeat structure common to sulfite and nitrite reductases (7). This superfamily also encompasses gene sequences of assimilatory nitrite and sulfite reductases from higher plants, fungi, algae, and bacteria (used biosynthetically) and the small, monomeric sulfite reductase fromDesulfovibrio vulgaris (35). The physiological role of the monomeric reductase is unresolved, but theDesulfovibrio vulgaris enzyme resembles spectroscopically the low-molecular-weight sulfite reductases isolated fromMethanosarcina barkeri and Desulfuromonas acetoxidans (24).
Members of the redox enzyme superfamily share enzyme properties or gene sequence motifs with the anaerobically expressed sulfite reductase fromSalmonella typhimurium (17), the inducible sulfite reductase from Clostridium pasteurianum(13), and the "reverse sulfite reductases" detectable in the phototrophic sulfur bacterium Chromatium vinosum and in the sulfur-oxidizing chemolithotrophThiobacillus denitrificans (31, 32). Thus, all characterized enzymes that catalyze either the oxidative or reductive (dissimilatory or assimilatory) transformation between sulfite and sulfide appear to be related. This study addresses the question of archetype. Was there a common progenitor, and if so, what was its physiological function? The recent observation of high sequence similarity between the DSRs of A. fulgidus andDesulfovibrio vulgaris (20), representatives of the Archaea and Bacteria domains, respectively, suggested either a horizontal gene transfer or a common origin of a highly conserved reductase. To distinguish between these alternatives, we determined the gene histories of the α and β subunits for representative sulfate reducers. Both were consistent with similar analysis of the 16S rRNA genes from these organisms, suggesting a single ancestral progenitor.
Isolation of nucleic acids, gene amplification procedures, and Southern hybridization.Genomic DNA was isolated from the reference organisms as previously described (4). The primers DSR1F (5′-AC[C/G]CACTGGAAGCACG-3′), DSR2F (5′-CTGGAAGGA[C/T]GACATCAA-3′, modified from reference20), DSR3F (5′-GAAGAA[C/G]ATG[A/T]ACGGGTT-3′), and DSR4R (5′-GTGTAGCAGTTACCGCA-3′, modified from reference20) were dissolved to a concentration of 10 pmol/μl. For PCR amplification, 1 μl of each primer solution, 10 to 100 ng of DNA, 5 μl of 10× PCR buffer (500 mM Tris [pH 8.3], 20 mM MgCl2, 5 to 10% Ficoll, 10 mM Tartrazine), 5 μl of 10× bovine serum albumin (2.5 mg/ml), 5 μl of 10× deoxynucleoside triphosphates (2 mM [each] dATP, dCTP, dGTP, and dTTP), and 2 U ofTaq DNA polymerase were combined in a final reaction volume of 50 μl and loaded and sealed in a capillary tube. After initial denaturation for 15 s at 94°C, amplification was carried out in a 1650 Air Thermo-Cycler (Idaho Technology) for 30 cycles with each cycle consisting of 15 s at 94°C, 20 s at 54°C, and 54 s at 72°C. The reaction was completed by a final extension at 72°C for 1 min. PCR products were loaded together with a 1-kb DNA ladder molecular size marker on a 0.8% agarose gel to evaluate the PCR. Southern transfers were performed by treating the gel with 250 mM HCl for 10 min (DNA depurination) and blotting the DNA onto a MagnaCharge Nylon membrane (MSI) following instructions published by Boehringer Mannheim Corporation (3a). A 243-bp double-stranded DNA probe labeled with digoxigenin-11-dUTP was prepared by PCR (as described above) with the primers DSR1F and DSR5R (5′-TGCCGAGGAGAACGATGTC-3′) and Desulfovibrio vulgaris template DNA. This probe targets a conserved region of the analyzed DSR α subunits. The blots were hybridized with the probe at 60°C overnight and washed at 65°C at intermediate stringency following the Boehringer Mannheim protocol. The digoxigenin-labeled probe and molecular weight markers were detected colorimetrically with the nitroblue tetrazolium salt and 5-bromo-chloro-3-indolylphosphate system (Boehringer Mannheim) according to the manufacturer's instructions.
DSR gene cloning, sequencing, and phylogeny inference.Untreated and EcoRI-digested PCR products were ligated into pCRTMII plasmids and transformed into ONE SHOT competent Escherichia coli cells following the manufacturer's directions (TA Cloning System; Invitrogen). DNA sequences were obtained from double-stranded insert templates with M13 forward and reverse, infrared dye-labeled primers and a 4000L automated sequencer according to the manufacturer's instructions (LI-COR). Deduced amino acid sequences were aligned manually by pooling the amino acids into six groups (9) with the GDE 2.2 sequence editor (33a). Nucleic acid sequences of the gene fragments were then aligned according to the amino acid alignment.
Protein phylogeny.To construct phylogenetic trees based on the amino acid alignments, we prepared three data sets: one contained the DSR α-subunit sequences, a second contained β-subunit sequences, and a third contained a concatenated α- and β-subunit data set. For distance and parsimony analysis, gaps and missing sequence information were coded as missing data, yielding 186, 191, and 377 positions for α-subunit, β-subunit, and α- and β-subunit data sets, respectively. For protein maximum-likelihood methods, all positions where two or more sequences had missing data were deleted, while at those positions where only a single sequence was missing information, missing data were coded as a 21st amino acid. Final data sets consisted of 180, 184, and 363 positions for α-subunit, β-subunit, and α- and β-subunit data sets, respectively. Protein distances were inferred by using a maximum-likelihood method implemented in the PROTDIST program, with the Dayhoff PAM 001 matrix as the amino acid replacement model. Trees were inferred from the distances by using FITCH with global rearrangements (11). Unweighted amino acid parsimony analysis was completed with test versions 4.0.0d59 and 4.0.0d60 of the PAUP* program written by D. L. Swofford. Maximum-parsimony trees were determined by the branch-and-bound algorithm. Protein maximum-likelihood trees were calculated in two ways. Exhaustive searches were performed by using the PROTML 2.2 (2) program with the JTT-f amino acid replacement model to select the tree which conferred the greatest likelihood on the data. To account for rate heterogeneity among sites, protein maximum-likelihood trees were also estimated with the PUZZLE 3.1 program employing the JTT-f model with a mixed eight-category discrete gamma-plus-invariant-site model with default parameter estimation methods (34).
Nucleotide phylogeny.All nucleotide-level analyses were based on first and second codon positions of alignments that corresponded to the amino acid alignments described above for the DSR sequences. α-Subunit, β-subunit, and α- and β-subunit data sets consisted of 384, 466, and 850 aligned positions, respectively. A total of 1,041 aligned positions were utilized for the 16S rRNA data set. In all cases, missing data or alignment gaps were treated as missing information. The PAUP* program (and references therein) was used to perform nucleotide parsimony, distance, and maximum-likelihood analysis. Distance matrices were estimated by the maximum-likelihood method with the Hasegawa-Kishino and Yano (HKY) model with a discrete gamma-invariant-site model with trees selected under the minimum evolution criterion. The transition/transversion ratio and rate heterogeneity parameters were estimated via maximum likelihood on an HKY maximum-likelihood-distance–minimum-evolution topology. Maximum-likelihood analysis was performed with the same model. Heuristic tree-searching procedures for distance and maximum-likelihood methods involved simple stepwise addition with tree bisection reconnection rearrangements. Unweighted parsimony analysis was performed as described above.
Bootstrap analysis.Bootstrap analysis for protein distance methods utilized programs in the PHYLIP package. Bootstrap estimates for the protein maximum-likelihood trees utilized the resampling estimated-log likelihood method implemented in the PROTML 2.2 program. All other bootstrapping was performed with the PAUP* program. For protein distance, protein parsimony, nucleotide distance, and nucleotide parsimony analyses, 500 bootstrap resamplings were analyzed. Due to time constraints, nucleotide maximum-likelihood bootstrap analysis was based on 250 resamplings.
We first evaluated four primers, designed on the basis of sequence conservation between the DSR genes of A. fulgidus andDesulfovibrio vulgaris, in different combinations for PCR amplification of genomic DNA from a wide variety of reference organisms (Table 1). One primer pair (DSR1F-DSR4R) amplified the expected ∼1.9-kb fragment from all 22 sulfate-reducing bacteria tested. No amplification could be observed with DNA from bacterial and archaeal species that do not derive energy from sulfate reduction (Fig.1), demonstrating that this primer pair does not amplify (i) genes encoding assimilatory sulfite reductase, (ii) genes encoding the sulfite reductase from an organism having the capacity to respire sulfite but not sulfate (Shewanella putrefaciens), or (iii) the genes for the reverse sulfite reductases, which show some similarity to DSR with respect to catalytic parameters and subunit composition (31, 32). This is also consistent with recent sequence analysis of this enzyme (siroheme sulfite reductase) from the sulfur-oxidizing phototrophic bacterium,Chromatium vinosum (16). Comparative analysis revealed that the evolutionary distance between the enzymes fromChromatium vinosum and Desulfovibrio vulgaris is greater than that separating the enzymes from A. fulgidus and Desulfovibrio vulgaris. Although these data suggest a yet-earlier divergence between oxidative and reductive modes of dissimilatory sulfur metabolism, in the absence of additional sequences for the oxidative type of DSR, we do not consider it further.
We sequenced the 1.9-kb amplification products fromDesulfobotulus sapovorans, Desulfonema limicola, Desulfococcus multivorans,Desulfobacter latus, Desulfovibriosp. strain PT-2, Desulfovibrio sp. strain PIB2,Desulfotomaculum ruminis, and Thermodesulfovibrio yellowstonii. However, the product fromThermodesulfobacterium commune was not stable in E. coli and sequence information is not yet available for this organism. We are evaluating alternative cloning strategies and hope to include this sequence in future analyses. All sequences showed high similarity to each other and to those previously determined forDesulfovibrio vulgaris and A. fulgidus (Tables 2 and3), and much less similarity to other members of the siroheme-containing redox enzyme superfamily (7). With the exception of reverse sulfite reductase fromChromatium vinosum, no extensive alignment was possible.
Phylogenetic trees for the DSR α and β subunits and combined α and β subunits were estimated from the amino acid and nucleotide data sets by distance, parsimony, and maximum-likelihood methods (Fig.2). Trees were also inferred from a 16S rRNA data set containing a wider array of Bacteria andArchaea (Fig. 3). Overall, highly similar orderings of taxa were found between 16S rRNA and DSR trees.
The archaeon A. fulgidus branches closest toThermodesulfovibrio yellowstonii and Desulfotomaculum ruminis in α-subunit, β-subunit, and α- and β-subunit DSR data sets (Fig. 2). However, which of these two bacteria is closest toA. fulgidus depends on both the DSR subunit and the phylogenetic methods. α-Subunit and α- and β-subunit amino acid-based analyses recover a Desulfotomaculum ruminis-A. fulgidus clade in the majority of bootstrap replicates, whereas nucleotide-level analyses of these data sets and both nucleotide and amino acid analyses of the β-subunit data set support a T. yellowstonii-A. fulgidus grouping. Trees inferred from the 16S rRNA data set also show the Archaea (represented by A. fulgidus and Methanococcus jannaschii) joining the bacterial subtree close to these two taxa withThermodesulfobacterium commune usually forming the deepest bacterial branch (26). Distance and maximum-likelihood methods are congruent in finding Thermodesulfovibrio yellowstonii the next taxon to diverge. Bootstrap support for the clustering of Thermodesulfovibrio yellowstonii,Thermodesulfobacterium commune, and A. fulgidus is strong only for distance methods (Fig. 3). Furthermore, the clustering of Desulfotomaculum ruminiswith these taxa is only moderately supported by parsimony and likelihood methods. Similar results were obtained with a taxonomically reduced 16S rRNA data set that included only those taxa used in the DSR analyses (data not shown).
For all methods with both DNA and amino acid data sets of all the DSR data sets, the δ-subclass of the Proteobacteria(δ-Proteobacteria) forms a clade that receives highly significant bootstrap support (all bootstrap values were >97%). The monophyly of the δ-Proteobacteria receives much poorer support from 16S rRNA analysis. This is largely due to a weak tendency for Desulfotomaculum ruminis to cluster with theDesulfovibrio group.
Although the branching order within the δ-Proteobacteriais very similar between DSR and 16S rRNA data sets, where taxa overlap, a few minor differences are apparent. First,Desulfovibrio vulgaris andDesulfovibrio sp. strain PT2 strongly form a grouping to the exclusion of all other sequences in the 16S rRNA tree (bootstrap values were ≥99% for all three phylogenetic methods). These two also form a grouping for β-subunit and α- and β-subunit data sets but do not form a clade in optimal protein maximum-likelihood or nucleotide maximum-likelihood trees of the α-subunit data set. However, for this data set, protein distance and nucleotide distance methods do recover the Desulfovibrio vulgaris-Desulfovibrio sp. strain PT2 grouping with 87 and 55% bootstrap support, respectively (data not shown). Several factors are probably responsible for the failure of the likelihood methods to recover this relationship. First, since the α-subunit data set contains relatively few aligned positions, inferences based on this data set will be subject to large random error. Furthermore, the relatively short branches leading to theDesulfovibrio vulgaris andDesulfovibrio sp. strain PT2 sequences in the α-subunit trees compared to the β-subunit tree (Fig. 2) suggest that the α subunit of these two organisms may have diverged so little from the common ancestral sequence of the δ-Proteobacteriathat the branch joining them is extremely short and cannot be resolved with the number of data available. Inclusion of more sequences in phylogenetic analysis often increases the efficiency of the methods for finding the correct topology (15). Consistent with this, our preliminary analyses of larger DSR data sets containing more δ-Proteobacteria with each of the phylogenetic methods recover a relationship between Desulfovibrio vulgaris and Desulfovibrio sp. strain PT2 in trees of α-subunit, β-subunit, and α- and β-subunit amino acid and nucleotide data sets. Furthermore, analyses of data sets including a partial α-subunit and complete β-subunit DSR sequence from Desulfovibrio gigas reveals that the latter organism is an immediate sister to a strongly supported Desulfovibrio vulgaris-Desulfovibrio sp. strain PT2 clade.
A second anomaly is the positioning of Desulfovibrio oxyclinae. In 16S rRNA trees, Desulfovibrio oxyclinae robustly groups with Desulfovibrio africanus, with these two taxa appearing as sisters to aDesulfovibrio vulgaris-Desulfovibriosp. strain PT2 clade (Fig. 3). However, all of the DSR data sets show it as a separate branch most closely related to the Desulfobacter latus-Desulfococcus multivorans-Desulfonema limicola-Desulfobotulus sapovorans clade, with moderate bootstrap support. Once again, however, inclusion of further δ-Proteobacteria DSR sequences (36a) suggests that this conflict may be an artifact of limited taxonomic representation. When phylogenetically broader data sets are considered, the bootstrap support for the Desulfobacter latus-Desulfococcus multivorans-Desulfonema limicola-Desulfobotulus sapovorans-Desulfovibrio oxyclinae clade decreases, indicating that the branching order among these groups is poorly resolved.
A final point of conflict between 16S rRNA and α- and β-subunit DSR topologies is the relative branching order ofDesulfotobacter latus and Desulfotobotulus sapovorans. In this case, the branches in question in the DSR trees do not receive strong bootstrap support, and conflicts between phylogenetic methods are apparent (Fig. 2), indicating once again that the branching order among these taxa is not well resolved.
Topology aside, there are several notable differences in branch lengths between the DSR and 16S rRNA trees. For instance, in the 16S rRNA tree, a long branch connects the Archaea,A. fulgidus and Methanococcus jannaschii, to theBacteria (Fig. 3). In contrast, archaeal and bacterial DSR sequences are not particularly distant; for α-subunit, β-subunit, and α- and β-subunit data sets, the branch leading to A. fulgidus is approximately the same length as branches leading to Desulfotomaculum ruminisand Thermodesulfovibrio yellowstonii. In contrast, the branch connecting the δ-Proteobacteria to the rest of the tree is relatively long in the DSR data set and quite short for 16S rRNA.
There are several explanations for these differences in branch length. First, it is possible that both sets of genes are tracing the same evolutionary history but have suffered periodic increases and/or decreases in their rate of substitution at different times. For instance, a periodic increase in the rate of substitution in the 16S rRNA gene may have occurred along the branch between Archaeaand Bacteria, leading to the long branch length observed relative to that in DSR trees. Similarly, an increase in substitution rate in both subunits of DSR may have occurred on the branch connecting δ-Proteobacteria to all other taxa. However, it is also possible that the disparity in branch lengths may betray different evolutionary histories for the 16S rRNA and DSR data sets. For instance, the high degree of similarity between A. fulgidusDSR and homologs from Desulfotomaculum ruminis andThermodesulfovibrio yellowstonii could indicate that the former organism acquired its DSR genes from one of the latter lineages by lateral gene transfer. Lateral transfer between gram-positive eubacteria and Archaea is not without precedent; for instance, the hsp70 and glutamine synthetase genes ofArchaea may have been acquired by lateral transfer from gram-positive eubacteria (5, 29). Moreover, lateral transfer would explain why sulfate respiration is not widespread among knownArchaea but is instead phylogenetically restricted toA. fulgidus and close relatives (37). The resolution of these alternatives will depend upon the availability of additional DSR sequences. In this regard, we note the recent publication of α- and β-subunit DSR sequences of the sulfite reductase of the crenarchaeote Pyrobaculum islandicum(23). Preliminary phylogenetic analyses by us show these sequences to be highly divergent but to share a most recent common ancestor with the Archaeoglobus sequences, suggesting that the Archaea are monophyletic in DSR trees. However, P. islandicum lacks the capacity for sulfate respiration, and its DSR may be under different functional constraints. Molitor and associates have suggested that the protein from P. islandicum and the sulfite reductases from sulfate reducers and from sulfur oxidizers represent three independent lineages that originated prior to the divergence of Archaea and Bacteria(23).
However, in the absence of additional data, the near congruence of 16S rRNA and DSR for sulfate-reducing Bacteria andArchaea suggests that the gene histories of the DSR subunits represent the phylogeny of the organisms. Because members of the domainArchaea are considered to be more related toEucarya than to Bacteria (10, 18, 38), one plausible implication is that DSR was already present in the progenitor of the three recognized domains of life. Although we cannot exclude the possibility that ancestral DSR evolved within eitherBacteria or Archaea soon after the split of the domains and was then transferred to the other domain by an early lateral gene transfer event, the capacity for sulfate or sulfite respiration appears to have a very early origin in either case.
This conclusion is justified only if these genes are orthologous and retain their ancestral physiological role. There are at least two supporting lines of evidence that the progenitor genes coded for an enzyme similar in function to the modern DSR. First, in contrast to assimilatory sulfite and nitrite reductases, both subunits of all sequenced DSRs contain a conserved ferredoxin-like domain. The identical position of this domain in the DSRs of Bacteriaand Archaea indicates that this unique feature of DSRs was present before the divergence of the two domains (8). Second, as life may have originated in hot environments (1, 19, 38), the occurrences of sulfate-reducing prokaryotes among hyperthermophilic Archaea (Archaeoglobus profundus and A. fulgidus) and deep-branching thermophilic bacteria (Thermodesulfovibrio yellowstonii andThermodesulfobacterium commune) are consistent with an early origin. Third, isotopic data suggest that dissimilatory sulfate reduction began 2.8 to 3.1 billion years ago (28, 33) but acquired global significance only after sulfate concentrations had significantly increased in the Precambrian oceans approximately 2.35 billion years ago (6). The isotopic data are reasonably consistent with a recent estimate of the time of domain divergence, ca. 3.1 to 3.6 billion years ago, based on sequence comparisons of a large number of different proteins (12). Since our data indicate that the progenitor genes of DSR evolved before or soon after the divergence of the three domains, organisms able to reduce sulfate, or at least sulfite, may have given rise to all known forms of bacterial and archaeal life. This view is consistent with recent speculations that respiratory electron transport systems evolved prior to oxygenic photosynthesis (30).
If our inference is correct, it is difficult to understand why the capacity for this lifestyle has such restricted phylogenetic distribution among Bacteria and Archaea. Dissimilatory sulfate reduction is found in only three primary bacterial lineages and is restricted to a single archaeal genus,Archaeoglobus. One possible explanation for the apparently limited phylogenetic distribution of sulfate-reducing microorganisms is that most bacterial and archaeal lineages have lost the appropriate genes during evolution. On the other hand, we might simply have failed to isolate representatives of the natural diversity of sulfate-reducing prokaryotes. We have started to systematically evaluate the second possibility by using the PCR primers described in this study to amplify DSR genes directly from total DNA isolated from a variety of habitats (sulfidogenic aquifers, gastrointestinal sites, microbial mats, lake sediments, and biofilm reactors). Our initial phylogenetic analyses of "environmental" DSR sequences have revealed novel sequences that are distinct from described sulfate-reducing assemblages (36a). This suggests great undescribed natural diversity of sulfate-reducing prokaryotes and is also consistent with the early origin of this possibly archtypical phenotype.
We thank F. Widdel, M. Fukui, D. Nelson, M. J. McInerney, R. Devereux, L. Krumholtz, J. Waterbury, and Y. Cohen for providing us with bacterial strains. Valuable discussions with W. Ludwig are gratefully acknowledged. We also thank M. Ragan, K.-H. Schleifer, O. Kandler, and N. Ramsing for critical reading of the manuscript. We are grateful to Mitch Sogin for allowing phylogenetic analyses to be performed in his laboratory. We thank David Swofford for allowing us to perform analyses with the test versions 4.0.0d59 and 4.0.0d60 of the PAUP* program and to publish the results.
M.W. was supported by a postdoctoral grant from the Deutsche Forschungsgemeinschaft (Wa 1027/1-1), and D.A.S. was supported by grants from the ONR and NSF. A.J.R. was supported by the Natural Sciences and Engineering Research Council of Canada.
- Received 12 January 1998.
- Accepted 24 March 1998.
- Copyright © 1998 American Society for Microbiology


text:
Buy Kola Kubes
Kola Kubes are small, brown, sugar coated cubes that are a retro favourite. These hard-boiled sweets were many people's favourite as a kid, and are often still spotted in sweet shops. They have a subtle taste of cola, and the layer of sugar gives them a slight fizz, so they're great for those who love fizzy drinks. Our wholesale kola kubes are supplied in large bags, and are unwrapped, so you can decant them into a glass or plastic jar, or sell them in smaller paper bags.
Kola Kubes can be dispatched from our UK based warehouses to domestic and international customers. Appleton Sweets has been established since 1945, and offers only the highest quality sweets such as our classic Kola Kubes. They've long been a favourite with people of all ages who have a sweet tooth, and will no doubt become a bestseller with your own customers.
CANDY CO KOLA CUBES - 3KG£7.69 (ex. VAT) £9.23 (inc. VAT)
Out Of Stock
TILLEYS U/W KOLA CUBES - 3KG£7.79 (ex. VAT) £9.35 (inc. VAT)
151 in stock


text:
In partnership project with the Genesee County Breastfeeding Coalition (GCBFC), MIBFN 310 Connect Flint has been active since late 2016. This project was borne of the Flint water crisis and aims to improve the maternity care system, with specific emphasis on training and building the community breastfeeding support infrastructure in Flint. Together with the GCBFC, MIBFN is working to increase the quantity and impact of diverse, multidisciplinary lactation supporters through the hospitals, outpatient clinics, local public health agencies, and grassroots support organizations.
This project is made possible through the generous support of The Community Foundation of Greater Flint, Flint Kids Fund. View all of our 310 Connect Flint partners here.
Get to know how MIBFN is taking a 360-degree approach in Flint by clicking the links below and view our infographic here.
Maternity Care
- QI JumpStart to Baby Friendly Hospital Collaborative: Provide Hurley Medical Center and Ascension Genesys Hospital the opportunity to participate in QI JumpStart to Baby Friendly Hospital Collaborative, free of charge to their organizations
- Custom Maternity Care Training & Tools: Leverage partnerships to incorporate consistency in Maternity Care Campaign messaging, saturating partner organizations with Coffective Training & Tools
- Outpatient Medical Provider Engagement & Tools: Engage Outpatient Medical Providers in coordinated Maternity Care Campaign, using Coffective Training & Tools and Michigan Breastfeeding Friendly Medical Provider Awards as an effective solution to engage and create buy-in, while empowering and providing strategic guidance, education and support
Learn more about MIBFN's Maternity Care campaign here.
Coalition Building
- Coalition infrastructure establishment with use of sustainability templates: Leverage lessons learned from other coalitions around the state and implement the use of a variety of tools in collaboration with the Genesee County Breastfeeding Coalition to help simplify and catalyze change in the community
- Meetings, celebrations and networking events: Align the community by hosting meetings and events that collectively bring hospital staff, leadership and systems-level partners together for an experience of networking, sharing and collaboration
- Community Engagement dashboard: Leverage use of the community engagement dashboard to identify and engage community stakeholders, expanding reach, increasing valuable consistency in messaging and identifying engagement, interest and completion within the Genesee County Breastfeeding Coalition
Learn more about MIBFN's mission-drive Coalition Building here.
- Sustainability of Community-based Champions: Engaging the expertise of established community leaders in building a sustainable infrastructure of mothers, families and dads as part of YOLO's Community-Based Breastfeeding Support Group, Baby Café of Genesee County and InvolvedDad's fatherhood engagement groups, mobilizing a system of at-home champions all of whom are trusted by the community, from the community and well equip to support breastfeeding success
- Certified Lactation Counselor Training: CLC community training will ensure that lactation support is available within Flint to the families that need it the most. Trained Lactation Counselors will be specifically recruited for participation in other programs, including; Baby Café and the Genesee Breastfeeding Coalition
- Participation in Webinar Series: Expand access to evidenced-based, equity-focused, and timely breastfeeding education the Great Lakes Breastfeeding Webinars are FREE and provided monthly webinar offering a CERP, social work contact hour, nurses' contact hour, and a certificate of attendance to attendees who can watch live and complete the post-webinar evaluation
- Quarterly Networking Meetings: Expand and engage breastfeeding stakeholder networks by cultivating relationships among local leaders, sharing best practices, and providing technical assistance. The aim of the Quarterly Network Meetings is to bring breastfeeding stakeholders together, in person, four times per year in various regions of the state to create opportunities to learn, share, and connect with one another
Learn more about MIBFN's Great Lakes Breastfeeding Webinars here and Quarterly Network Meetings here.


text:
About OXi4503
Our lead VDA product is OXi4503, which is in a Phase 1b clinical trial in relapsed/refractory acute myeloid leukemia. OXi4503 has a unique dual mechanism of action that disrupts the shape of tumor bone marrow endothelial cells (BMECs) through reversible binding to tubulin at the colchicine binding site, downregulating intercellular adhesion molecules. This causes alterations to the endothelial cell shape, releasing quiescent adherent tumor cells from BMECs and activating the cell cycle, making the tumor cells vulnerable to chemotherapy. OXi4503 also directly kills tumor cells via myeloperoxidase activation of a fluorquinone cytotoxic mediator.
The following select publications are from the peer-reviewed literature and discuss the scientific data surrounding the use of OXi4503.
OXi4503 (Combretastatin A1-Phosphate/CA1P)
Clinical—Phase 1 Studies:
Bosse RC, Wasserstrom B, Wise E, Meacham A, Cogle CR. Chemosensitizing leukemia by targeting the leukemia microenvironment with vascular disrupting combretastatins [abstract]. Blood. 2014;124(21):2315.
Cummings J, Zweifel M, Smith N, Ross P, Peters J, Rustin G, et al. Evaluation of cell death mechanisms induced by the vascular disrupting agent OXi4503 during a phase I clinical trial. Br J Cancer. 2012;106(11):1766-1771.
Patterson DM, Zweifel M, Middleton MR, Price PM, Folkes LK, Stratford MR, et al. Phase I clinical and pharmacokinetic evaluation of the vascular-disrupting agent OXi4503 in patients with advanced solid tumors. Clin Cancer Res. 2012;18(5):1415-1425.
Turner D, Gonzalez A, Pettiford L, Meacham A, Wise E, Bosse RC, et al. A phase I study of the vascular disrupting combretastatin, OXi4503, in patients with relapsed and refractory acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) [abstract]. Blood. 2013;122(21):1463.
Benezra M, Phillips E, Tilki D, Ding BS, Butler J, Dobrenkov K, et al. Serial monitoring of human systemic and xenograft models of leukemia using a novel vascular disrupting agent. Leukemia. 2012;26(8):1771-1778.
Bosse RC, Wasserstrom B, Meacham A, Wise E, Drusbosky L, Walter GA, et al. Chemosensitizing AML cells by targeting bone marrow endothelial cells. Exp Hematol. 2016;44(5):363-377.
Hill SA, Toze GM, Pettit GR, Chaplin DJ. Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503. Anticancer Res. 2002;22(3):1453-1458.
Hua J, Sheng Y, Pinney KG, Garner CM, Kane RR, Prezioso JA, et al. Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate. Anticancer Res. 2003;23(2B):1433-1440.
Madlambayan GJ, Meacham AM, Hosaka K, Mir S, Jorgensen M, Scott EW, et al. Leukemia regression by vascular disruption and antiangiogenic therapy. Blood. 2010;116(9):1539-1547.
Siemann DW, Shi W. Dual targeting of tumor vasculature: combining Avastin and vascular disrupting agents (CA4P or OXi4503). Anticancer Res. 2008;28(4B):2027-2031.
Siim B, Walicke P, Chaplin D. Activity of the vascular disrupting agent Oxi4503 against an acute myelogenous leukemia xenograft model [abstract]. Cancer Res. 2009;69:5640.


text:
Managed Security Services
Top 10 Managed Security Services Leaders by Analyst Rating(of 36 products) GET THE IN-DEPTH REPORT
Managed Security Services
AT&T Managed Security Services
AT T, a key service provider in the Comprehensive National Cybersecurity Initiative (CNCI), offers a full spectrum of scalable, standard or customized cybersecurity solutions to support the needs of Government Agencies. In conjunction with many individual Government Agencies with specific requirements, AT T has developed custom IT and cybersecurity solutions ranging from large, managed networks to innovative, standalone cyber tools.
e-Cop Managed Security Services
e-Cop's Managed Security Services (MSS) are designed to help enterprises and government agencies to cost-effectively outsource and manage its organisation's security needs. Powered by its award-winning proprietary technology, e-Cop's Global Command Centres (GCC) are strategically located across the globe to help enterprises prevent, detect, and respond to vulnerabilities and threats.
BT Managed security services
BT Assure Managed Cloud, supports all different work styles and corporate connectivity needs. All employees, wherever they are based and whatever technologies they use, can now connect securely and safely to company resources. Offered as a cloud-based service, it helps ensure consistent protection and policy for everyone, both inside and outside the network—including mobile users and devices.
CSC Managed Security Services and Solutions
CSC offers a complete array of Managed Security Services for traditional data center, endpoint, identity and network management, as well as additional services to secure applications and next-generation platforms including cloud, mobility, and big data and analytics. Our highly skilled practitioners and Risk Management Centers bring an integrated approach to tools, technology and services, helping you focus on compliance, enterprise risk management and global threat intelligence, rather than simply reacting to the latest security metrics.
Founded in 2000, CIPHER is a global cybersecurity company that delivers a wide range of Managed Security Services and Security Consulting Services. These offers are supported by the best in class security intelligence lab: CIPHER Intelligence. With offices located in North America, Europe and Latin America, 24×7×365 Security Operations Centers and R D laboratories, the services are complemented by strategic partners around the globe. CIPHER is a highly accredited company holding ISO 20000 and ISO 27001, SOC I and SOC II, PCI QSA and PCI ASV certifications. We have received many awards including Best MSSP from Frost Sullivan for the past six years.
CenturyLink Managed Security Service
It's a scary digital world out there with countless threats trying to interrupt your business. Fortunately, Managed Security Service provides comprehensive threat protection, options for malware mitigation, Web filtering, spam filtering, access control, and VPN support. As a managed security service provider, we offer 24/7/365 monitoring, management, and support-including easy visibility into service information through an online self-service portal. Rely on our managed security services to keep threats out of your business.
Trustwave Managed Security Services
Threats are growing more hostile. Budgets are tight. Skills are at a premium. And business imperatives like mobility, social media, web applications and big data can pose risks as well as inefficiencies if they're not properly managed. Trustwave can help you solve these challenges and close that gap - through integrated technologies, unparalleled threat intelligence, and highly flexible managed services designed to meet the unique demands of your business.
HP Managed Security Services
Even with increased spend on security these days, most enterprises don't have enough time or in-house talent to cover the growing demand. HP can help. Our Managed Security Services extends your team's capabilities, leveraging the expertise of more than 5,000 security experts to improve your security posture, reduce risk, and increase security effectiveness.
HCL Managed Security Services
HCL's Managed Security Services dispersed through four fully operational Security Operation Centers (SOC) offer real-time protection to organizations, thereby reducing the risks in today's ever-changing security threatened environment. HCL offers a balanced approach, compliance, proactive security, techno-centric focus and flexible delivery models to its customers across the globe. The service offerings are bundled together so as to take care of all security operations in a customer's infrastructure environment.
IBM Managed Security Services
Strengthen your information security defenses and lower your costs. Today's rapidly evolving threat landscape demands smarter and more responsive managed security services. IBM Managed Security Services offer the industry-leading tools, technology and expertise to secure your information assets 24/7/365, often at a fraction of the cost of in-house security resources.
Tata Communications Managed Security Services
We offer a complete array of managed secu- rity services. We can provide you with a com- prehensive managed security system for your entire enterprise—or you can choose one or two services to fill the gaps in your system. Our offering includes firewalls, threat manage- ment, intrusion detection and prevention, DDoS detection and mitigation, email security, vulnerabil- ity testing and manage- ment, and much more.
NTT Managed Security Services
NTT Com's global security solutions offer fully managed protection platforms for your business. Protect your mission-critical IT assets with NTT Com. WideAngle, the global integrated security service from NTT Communications, provides total security for your information and communications technology (ICT) environment.
Verizon Managed Security Services - Monitoring and Analytics
The Verizon Cyber Intelligence Center is where our threat intelligence comes alive—bringing together our dedicated security experts, state-of-the-art technology and analytics tools, and fast, efficient attack-detection processes. Since it gathers and applies threat intelligence on an ongoing basis, the Center helps power and improve our security services, helping us fight potential attacks by identifying, understanding, and responding to threats as early as possible.
ViaWest's Managed Security Services provides for controlled perimeter access to customer site or hosted infrastructure in a ViaWest Data Center. This service includes firewall hardware, management, installation, 24/7 monitoring and support, and sparing of the firewall hardware.
Paladion Managed Services
Paladion managed services provides continuous protection against security risks. It helps in building a security baseline and improves upon it on a continuous basis, thus providing a secure environment for businesses to grow and multiply. Our offering helps customers in forming a single unified management for all security risks in their environment. The offering is backed with an SLA on security assurance, thereby quantifying as well as limiting the security impacts to an organization.
EarthLink Managed Security Services
With Managed Security you can minimize risk to your assets and lower operational costs associated with managing, monitoring and securing your infrastructure. Our CISA® and CISSP® certified security professionals serve as an extension of your staff, mitigating threats to your business and working directly with your team to reduce IT risk. Through proactive security monitoring and documented security policies and procedures, our Managed Security services enable you to comply with government and industry regulations.
ViaWest's high-speed Intrusion Detection/Prevention service (IDPS) continually scans for anomalous, inappropriate, and unauthorized access attempts at the edge of your network. Our IDPS offering captures and inspects all network traffic, sending you email alerts when there's danger, and alerting ViaWest's data center customer support in the event of an escalation.
Managed Security Services - Outsourcing - Cloud services
Managed security services are the practice of transferring day-to-day related management responsibilities as a strategic method for improved, effective
Wipro Managed Security Services
Primarily Managed Security Services (MSS) are driven by the need for Cyber security which includes 24/7 security, monitoring, vulnerability management, security operations and meeting compliance requirements. The focus of security is evolving from reactive response to proactive investigation and management of advanced threats. This helps improve the bottom line through securely embracing new technologies, mitigating cyber threats and regulatory compliance while demonstrating business value.
Locuz Managed Security Services
Locuz Managed Security Services provides you with a comprehensive and resilient service offering that enables access to a pool of highly skilled security engineers and proven processes that work together seamlessly to fuel the delivery of our services to thousand of our customers around the globe.
The threat landscape is evolving at escalating speed. Responding to these risks requires smarter, intelligence-driven solutions that focus on maximizing resource effectiveness and minimizing damage incurred.Established out of years of experience in the ongoing monitoring and management of security technologies and a myriad of endpoints for enterprise clients, Optiv's managed security services (MSS) are delivered by our team of vulnerability and security researchers, from multiple security operation centers across the country to support your organization on-demand, 24 hours a day, 365 days a year.
Symantec Managed Security Services
Symantec has been a leading provider of managed security services for over 10 years, and has been recognized by leading industry analysts and publications. Proven expertise delivering security monitoring and management services around the clock, trusted by leading enterprises around the world.
Security Services
As data management moves into the cloud, these concerns can become more pronounced. Alert Logic provides a comprehensive, cloud-based portfolio of Security-as-a-Service solutions that incorporates leading-edge security products, expert-managed services, and an integrated research team that continually assesses and monitors your environment to ensure that your data remains safe — even as new threats develop and regulations evolve.
Dell SecureWorks Managed Security
Dell SecureWorks' breadth of Managed Security Services and industry-leading flexibility enables us to provide you with just the right solution to meet the requirements of your industry or particular network security challenge. In order for your organization to meet compliance, our IT security experts can assist you through several services ranging from log monitoring, firewall management to even Security Awareness Training solutions to better protect your network.
Solutionary Managed Services
Solutionary is the Next Generation Managed Security Services Provider (MSSP). With a focus on managed security services (MSS) and global threat intelligence, Solutionary protects traditional and virtual IT infrastructures, cloud environments and mobile data. Clients are able to optimize security programs, make informed decisions, achieve compliance and reduce costs.
Comodo cWatch
Comodo cWatch is a cybersecurity platform that delivers comprehensive protection for websites, web applications and web servers with its six-layer stacked security solution. It ensures complete website protection with early detection, instant malware removal and proactive preventive methods. It is a cloud-based, managed security service that leverages actionable intelligence to protect networks against malware, blacklisting, hacking and more. It can be used with any CMS, regardless of size or purpose.
Mike Simonton
Tuliva is a Managed Services provider, provdiging hybrid IT Security Services and Cloud Hosting.
Managed Endpoint Security
Protect your business from malware and cyber-threats with affordable managed services featuring CylancePROTECT® advanced threat protection
Nuance Security Suite
Contact Center Solution Suite
eSentire provides organizations with dedicated threat detection and response, safeguarding businesses from known and hidden threats across their attack surface. It leverages a proprietary AI methodology for threat hunting and advanced automation, eSentire's innovation in the MDR industry solves some of cybersecurity's biggest challenges. Security is not only a data volume but also a technology problem that requires a modern approach to AI and expert analysts. eSentire helps process massive amounts of data, providing full threat visibility and response to protect the business's assets.
Radware Managed Security Service
Radware Attack Mitigation Solution for DoS Protection Service Providers: Radware offers DoS protection service providers with the most advanced attack mitigation solution
Cyber Security Services & Capabilities
Our expertise and skills uniquely deliver customized cyber security solutions. We solve the world's most difficult security problems. We are the world's beacon for knowledge and education, arming businesses and organizations to Discover, Develop, and Defend againstcyber threats and cyber terrorism.
Managed Security Services
Masergy's Managed Security solutions offer comprehensive managed detection and response services on a global scale, tailored to meet any budget. We take the workload off of your staff to help you optimize your security resources and improve outcomes.
Real People... with Data
We know selecting software can be overwhelming. You have a lot on the line and we want you to make your project a success, avoiding the pitfalls we see far too often.
As you get started with us, whether it be with Software Requirements templates, Comparing, Shortlisting Vendors or obtaining that elusive Pricing you need; know that we are here for you.
Our Market Research Analysts will take calls, and in 10 minutes, take your basic requirements and recommend you a shortlist to start with.


text:
The HP Envy x360 15t 3EC87AV_1 is a higher-end 2-in-1 convertible notebook. This is a configurable model for year 2018. It's available on the official HP Store. The aluminum-clad Envy x360 15t 3EC87AV_1 has a 15.6-inch touch-screen on a pair of 360-degree hinges. There are two screen resolution choices: sharp Full HD and ultra-sharp 4K. Besides finger touch, the screen can be used with an optional active digitizer pen. An interesting display feature is the notebook's optional privacy screen. The 2-in-1 PC has a full-size keyboard with numeric pad and optional key backlight.
Inside, the Envy x360 15t 3EC87AV_1 packs the the 8th Generation Intel Core processors – the excellent quad-core Intel Core i5-8250U and i7-8550U. Besides the basic Intel UHD 620 integrated graphics, HP optionally offers the Nvidia GeForce MX150 4GB lower-end dedicated video card for smoother gaming than with the UHD 620. The laptop comes with 8, 12 or 16 Gigabytes of system memory. For data storage, HP has provided numerous options – a 1-Terabyte hard drive combined with 16GB of Intel Optane memory for speed boost, a combination of a 1TB HDD and 256GB of fast solid state drive storage, or purely SSD storage with 512GB or 1TB capacity.
The included battery has a decent capacity of 52.5 WHr. It enables a run time of to 9 hours and 15 minutes on the laptop configuration with the Full HD screen resolution. On 4K models the battery life is shorter because of the higher resolution.


text:
"Enterprise Mobility – Are you ready" MobileMonday Aug 10th 2012 @ Hotel Amar Vilas
Posted by momoindore in MoMo Indore, Uncategorized on July 20, 2012
To register for the event visit http://momoindore-enterprise.eventbrite.com/
Let's face it, mobility has always been a fundamental part of businesses with the help of IP and SIP communications and other multimedia desk phones, however, such equipment only makes it possible to connect when in the office. In order to meet the advanced requirements of an enterprise, mobility must be taken to the next level. And in the wake of the mobile evolution, enterprise mobility has taken a new form and importance.
Enterprise Mobility is becoming increasingly important as businesses attempt to leverage mobile communications to stay connected. As enterprises move to mobile and virtual workforces, the right communication tools are necessary to simplify enterprise mobility.
The use of smartphones and tablets are especially beneficial for enterprise mobility keeping employees connected whether at the office or when working off-site remotely. With IP communications on the rise and mobile devices like smartphones and tablets becoming an everyday commodity, the push to the mobile workforce is now easier than ever before.
But the idea is not to move every SMB or enterprise out of the office, rather the concept is to create the alternative of having a mobile work environment to keep employees connected and working no matter where they are located.
While enterprise mobility is most beneficial to those who travel, employees on-the-road are not the only ones who can take advantage of mobility options. With the constant battle for time in the workplace, being able to provide employees with tools to work while on-the-go is one of the biggest assets a company can possess.
Whether you have a meeting across the country or down the street at a local coffee shop, the ability to remote, call, or log-in to your work server, is not only advantageous for your productivity, but also for the overall well-being of your company.
Now MobileMonday Indore chapter brings an interactive session on "Practices and Advancements on Enterprise Mobility"
Indore 452001, Madhya Pradesh, India
- iPad @ Enterprise – Access and manage document on the go by Varun Gupta, InfoBeans (www.infobeans.com)
- Enterprise Mobility in Insurance Business By Nilesh Maheshwari @eMorphis Technologies (www.emorphis.com)
- Enterprise Mobility Security and Threats By Mrityunjay Chauhan, Ideavate Solutions (www.ideavate.com)
- How to develope cost effective mobile solutions for multiple platforms and form-factors? by Aditya Saxena, Impetus (www.impetus.com)
- Enterprise Mobility in BFS, Harish Shinde, Diaspark (www.diaspark.com)
MobileMonday 1st Event on VAS'o'Mania
Posted by momoindore in MoMo Indore on May 24, 2011
Mobile Monday, an international forum for developers of mobile Value Added Services and mobile technology professionals, today organized a 1-day conference VAS'o'Mania: realizing the VAS opportunity, in association with Bharti Airtel Ltd and LNCT Group of Colleges. VAS'o'Mania also marked the launch of the Indore Chapter of Mobile Monday.
Value Added Services have gained a huge significance in the global mobile telephone industry in the recent past. With newer Value Added Services getting introduced in the mobile market every day, the normal mobile phones have got converted into Smart Phones making lives of millions of users more and more convenient. On the occasion of the recently observed World Telecom Day, the emergence of Value Added Services was a highly talked about at the global level.
With VAS'o'Mania, a successful attempt was made to make the students learn about the life cycle of a Value Added Services, to motivate and inspire the professional developers of Value Added Services working in Indore and surrounding areas and to promote the consumption of Value Added Services in Madhya Pradesh.
The conference was inaugurated at LNCT Auditorium by Mr. Suprabhat Chouksey, Managing Director, LNCT Group, Mr. Rajnish Kaul, Chief Operating Officer, Mobile Services, Madhya Pradesh and Chhattisgarh, Bharti Airtel Ltd and Mr. Nilesh Maheshwari, Founder, Mobile Monday Indore and Chief Executive Officer, eMorphis Technologies, Indore.
The students and the mobile professionals, attending the sessions in large numbers, learnt the nuances of Value Added Services by witnessing the presentations by renowned speakers from the mobile Value Added Services and information technology sector. The conference opened with the presentation by Nilesh Maheshwari, CEO, eMorphis (http://www.emorphis.com ) . He shared information about the latest Value Added Services and applications and the new technologies and operating systems, while talking about the future of Value Added Services. Mr. Priyam Bose, Manager – Developer Relations, Forum Nokia, Nokia India gave the mobile manufacturers' perspective on Value Added Services, the latest operating technologies and the Indian mobile applications market. He also explained the meaning of a smart phone. Mr. Vijay Jain, CEO, Astute Technologies shared his views on the ideation of Value Added Services, programming and testing of Value Added Services products. Venkatesh Vijayraghavan, Head – Sales and Marketing,
Mobile Services, Madhya Pradesh and Chhattisgarh, Bharti Airtel Ltd. spoke about the identification of a new Value Added Services, its life cycle and the latest trends in consumption of Value Added Services across the world, country and the state. The conference ended with session by Mr. Prem Rathi, Director – Busness Development, Value Added Services, Impetus Technologies, who spoke about the consumers' perspective on Value Added Services. He also summarized the learning from the entire conference recounting the sessions by all the speakers.
Mr. Suprabhat Chouksey, MD, LNCT Group said, "On behalf of the LNCT Group, I thank Mobile Monday and Bharti Airtel for organizing VAS'o'Mania at LNCT. This is indeed a first-of-its-kind conference in Indore giving exposure to global information to our students."
Mr. Rajnish Kaul, Chief Operating Officer, Mobile Services, Madhya Pradesh and Chhattisgarh, Bharti Airtel Ltd said, "The customers' desires of making the most of their mobile phones have been and will remain the prominent growth driver behind the emergence of Value Added Services. High quality GPRS connectivity has been another reason for growth of Value Added Services business. Airtel has been the front runner in providing unique and innovative value added services in the Indian market."
Mr. Nilesh Maheshwari, Founder, Mobile Monday Indore said, "Indore boasts of a huge number of developers of Value Added Services and mobile technology professionals. We are delighted to launch the Indore Chapter of Mobile Monday, which will create a unique knowledge sharing forum for them as well as the student community."
…….MobileMonday – Indore Presents VAS'o'Mania………
Posted by momoindore in MoMo Indore on May 9, 2011
Mark your calendars for a day long event on 19th May 2011, 11:30 AM…See Agenda Below
To connect with the VAS community in the region.
To make the masses aware of the life cycle of a VAS product.
To promote the consumption of VAS.
Venue: LNCT Auditorium , Near Aurobindo Hospital, Sanwer Road, Indore
Registrations open at http://momoindore.eventbrite.com/
Event Sponsors:
|1145 to 1215
|30 Mins
|Nilesh Maheshwari,
CEO, eMorphis Technologies
|To bring the audience to a common platform with an overview on the subject
|1215 to 1300
|45 Mins
|Priyam Bose,
Developer Relations Manager,
Forum Nokia, India
|To give the hardware community's perspective on VAS and Apps
|1300 to 1345
|45 Mins
|Sponsored by LNCT Group
|1345 to 1430
|45 Mins
|Jay Jain,
CEO, Astute Systems Technology
|To share the developers' story on VAS development
|1430 to 1515
|45 Mins
|Venkatesh Vijayraghavan,
Head – Sales and Marketing, MPCG, Bharti Airtel Ltd.
|Providing the mobile service provider's perspective on the VAS
|1515 to 1600
|45 Mins
|Mr. Prem Rathi,
Director – Business Development, Value Added Services, Impetus Technologies.
|Providing a user's perspective and summarizing the day
MobileMonday Indore Chapter Launched
Posted by momoindore in MoMo Indore on February 24, 2011
In order to make Indore get the global mobile advancements advantage locally, MobileMonday, Finland and eMorphis, Indore have recently signed an agreement for the MobileMonday Indore chapter at Mobile World Congress, Barcelona, Spain.
MobileMonday (MoMo) is an open community platform of mobile industry visionaries, developers and influential individuals fostering brand neutral cooperation and cross-border P2P business opportunities through live networking events to demo products, share ideas and discuss trends from both local and global markets.
MobileMonday celebrates 11 years of collaboration, community, and innovation with the new chapter launch in Indore, India. With Indore becoming its 115th chapter, MobileMonday is now active in all continents. Indore mobile community will join the worldwide group of mobile movers and shakers under the direction of Nilesh Maheshwari, Founder & CEO of eMorphis Software Technology Solutions, an outsourced software development company focused on end to end mobile software solutions design and development. eMorphis is also focused on strategic consulting and corporate training on higher end technologies. It is a global specialist, providing software product/application engineering services to Independent Software Vendors (ISVs), software enabled businesses and companies that work on embedded software. Their focus area is enterprise mobility, core server engineering and Machine2Machine systems development.
The Indian telecom sector is opening up with new possibilities and opportunities. India has shown a massive growth rate in telecom sector by crossing 750 million mark of wireless subscriber, which has made India a very hot market for mobile value added services and mobile application development. India is one of the key players in developing mobile echo system and mobile application development for product companies all across the world. Indore has joined the flow of development with eMorphis doing a tie-up with MobileMonday to make the city mark milestones in the Mobile industry. For the same, the two have recently signed an agreement at the Mobile World Congress (MWC), Barcelona, Spain.
"India is a huge mobile market with plenty of innovation and potential that rest of the world should be aware of. We hope that with the MobileMonday partnership, Indore and overall Indian businesses can benefit from our global network as well create a vibrant ecosystem locally," said Jari Tammisto, CEO of MobileMonday Global.
"Indore is emerging as an educational hub and is now luring many MNCs to setup their software development centers here. Our goal for MobileMonday Indore is to connect the global mobile community with the local businesses, software developer community and educational institutes to help them keep pace with global advancements and continue their innovative work by creating an interactive network for finding partners, investors and clients. We want to see MobileMonday Indore as a key influencer for the mobile industry in the Central India," commented Nilesh Maheshwari, founder of Mobile Monday Indore India chapter.


text:
Most of us live without the constant fear of violence. Whilst it may not be a conscious realisation, we live our lives knowing that we are safe and protected and that we have good law enforcement which, on the majority of occasions, will successfully protect us from abuse.
But this is not true for everyone.
Throughout the developing world, fear of violence is part of everyday life for the poor. It's as much a part of poverty as hunger, disease or homelessness and is devastating the developing world. It is only more difficult to see. Without effective justice systems to protect them from violence, the world's poor live in a state of fear.
The poorest are so vulnerable because their justice systems – police, courts and laws – don't protect them from violent people. While their wealthier neighbours can pay for security guards, high walls and safe homes, the poor cannot. The threat of violence is relentless and pervasive; the poor live with a constant threat of being raped, robbed, assaulted or exploited.
For the poor, the risk of violence is part of their every day.
Gender violence kills and disables more women and girls than cancer, traffic accidents, malaria and war combined – World Health Organisation
With incomes for the global poor hovering around $1-$2 a day, the average person cannot hope to pay legal fees – ILO
Critically, this violence is not only destroying individual lives, but undermining the world's efforts to end poverty.
In nearly 20 communities throughout the developing world, International Justice Mission (IJM) fights everyday violence against the poor. Specifically, we focus on addressing: sex trafficking; sexual violence; slavery; police abuse of power; property grabbing; and citizenship rights abuse.
We protect the poor from such violence by partnering with local authorities to:
Rescue victims
Bring criminals to justice
Restore survivors
Strengthen justice systems
Raped by three men when she was 13, Griselda finally received justice after five years of IJM's support and is now thriving as she speaks up on behalf of other survivors.
After languishing in prison for 18 months for a crime he hadn't committed, and enduring another 18 months of uncertainty after he was released on bail pending an appeal of the wrongful conviction, Michael's name was finally cleared and he was a free man once again.
Charito* was rescued from sex trafficking when she was 14 years old. With the conviction of her trafficker secured, Charito said, "The justice I've been looking for, for almost 8 years ... now I have it."
But we don't stop at rescuing people who have been abused. Our ultimate goal is to prevent the violence from happening in the first place. All of our work is designed to drive maximum-impact, long-term transformation that will make the poor safe enough to thrive.
Cebu, the Philippines: After four years of IJM casework, independent researchers found a 79% decrease in the availability of children being sold for sex in Metro Cebu, the Philippines.
Cambodia: In the early 2000s, several research studies in Cambodia found that between 15-30% of those prostituted were minors. Today, IJM's research and investigation shows that the prevalence of minors in sex establishments in Cambodia's 3 largest cities is down to 8.16% - and the prevalence of minors under 15 is now below 1%.
Throughout the world, IJM is fuelling the global justice movement by drawing the world's attention to everyday violence, influencing leaders to become champions for protecting the poor and rallying all people of good will to the fight.
Here in the UK, we are applying IJM's unique global experience to strengthen the UK justice system and encourage the UK – including the government, the Church and a new generation – to lead the way in addressing everyday violence, both globally and locally.
You are encouraged to join us at the Friends Meeting House, Manchester on Tuesday 23rd September for the Labour Party Conference Prayer Breakfast, led by IJM. Learn more about everyday violence, pray for an end to this hidden plague and be inspired to take up the call for justice.
*A pseudonym has been used for the protection of this IJM client.


text:
I'm prepping the front for some paint, but first I had to get all the gross built-up crud out from behind those headlights!
I took the headlight bulbs out, as well as the metal shroud things behind them. They are pretty rusty, probably from all the moisture behind the lights over the years, so I think I will clean them up and paint them black. I broke one of the brittle plastic clips on the driver's side light while attempting to get it to unscrew, but I think it will be fine as is.
I bought some ZEP industrial strength degreaser spray and scrubbed away the built up black tar slime that was there. It came out pretty well – not perfect but definitely pretty clean and grime-free. I also started a bit into the engine bay, but I will save that work for another day. The degreaser works really well, with a little bit of scrubbing with shop towels. I think I'll need to get some gentle nylon scrubbers or sponges (maybe a toothbrush) to get into some of the smaller spots.
Next step is to lightly sand and spray the front fascia flat black and then put the metal bumper back on. Because I've decided to remove the rubbery trim around the car, I'm going to need to modify the bumper covers because they will stick out too far on the sides. I need to determine the best way to do that, so I may leave the bumper covers off for now.
Also, I've gotta finish up pulling that dent in the side panel and get some more sanding and grinding in.


text:
Councilwoman Liz Crowley, who's competing for the Democratic nomination in a northeastern Queens congressional seat, announced an impressive $100,000 fundraising haul considering she announced her campaign just ten days ago.
"Support for Elizabeth Crowley is growing rapidly because people believe we need an independent voice for Queens neighborhoods in Congress," her campaign's spokesman, Eric Yun, said in a statement this morning. "No one will run a more competitive campaign."
Ms. Crowley is battling perceptions that her campaign is a third wheel in a Democratic primary dominated by Assembly Members Rory Lancman and Grace Meng, and showing serious fundraising chops is certain to help.
Mr. Lancman, who was previously campaigning against Republican Congressman Bob Turner before redistricting changed his aims, told The New York Times he had raised $130,000 two months ago, seems likely to post a strong number by the April 15th reporting deadline. Ms. Meng is also a successful fundraiser, evidenced by the $1 million she has in her State Assembly campaign account (which isn't transferable to her congressional efforts).
Whoever wins the June 26th Democratic primary will face off against GOP Councilman Dan Halloran in November.