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ddn Editorial Roundtable: Ethics and stem cell research
August 2011
Since the first derivation of embryonic stem cells (ESCs) in mice in 1981 and subsequent discoveries involving human ESCs (hESCs), this form of stem cell research has been the subject of much ethical, moral and social controversy. In fact, in an attempt to resolve some of these concerns and ensure that important medical discoveries continue to progress, the last three American presidents and their government colleagues have set policies impacting ESC research in various ways. Where ambiguity exists in this debate on a federal level, some states have drawn a clear line in the sand about which forms of stem cell research may be conducted and publicly funded. And while legislators may lack the appetite to tackle this debate, plaintiffs in lawsuits filed at every court level are seeking the last word on the use of embryos in stem cell research.
In this, the second installment of our three-part series on trends in stem cell research, we brought together three individuals engaged in various forms of stem cell-related research to discuss some of the controversies surrounding this burgeoning scientific field. Their views on the use of different types of stem cells, the promise they hold for patients and some of the public concerns about them are diverse and insightful.
Participating in this roundtable discussion were the following researchers:
Dr. Theresa Deisher, founder, CEO and chief scientific officer of AVM Biotechnology, a Seattle-based company "dedicated to the discovery, development and commercialization of safe, effective and affordable pro-life medicines." After earning her Ph.D. in molecular and cellular physiology from Stanford University in 1990, Deisher went on to discover adult pluripotent stem cells isolated from the heart, which she patented and assigned to ZymoGenetics in 1998, six months before Jamie Thompson patented the first human embryonic stem cell lines. She also discovered FGF18 (which she also patented and assigned to ZymoGenetics), a very potent mesenchymal stem cell growth factor currently in clinical trials for osteoarthritis and cartilage repair. Deisher also derived embryoid-body like structures from umbilical cord blood, a discovery which she patented and assigned to Amgen. Deisher is also one of the named plaintiffs in the Sherley, et al. v. Sebelius, et al., lawsuit challenging federal funding of embryonic stem cell research.
Dr. Verna McErlane, director of commercial operations at Sistemic Ltd., a Glasgow, Scotland-based firm that provides miRNA-based products to the drug development, cell therapy and bioprocessing markets. McErlane earned her Ph.D. in preclinical cancer drug development and spent time working at the Gray Cancer Institute in London, where she was involved with the formation of SPEAR Therapeutics Ltd. prior to moving to the University of Dundee, Scotland to pursue evaluation of prodrug anticancer strategies. Subsequently, she was chosen to take part in the Saltire Foundation fellowship program and moved to Boston and attended Babson College before working with Genzyme on its new business initiatives. She also held an international market development position with Axis-Shield in Dundee, Scotland. McErlane was the recipient of the Galen Pharmaceutical Prize in 1999.
Dr. Mark Pittenger, CEO and chief scientific officer of Pearl Lifescience Partners LLC, a firm in Baltimore, Md., that develops vaccines against infectious enveloped viruses using bioengineered cell lines. Pittenger is also a consultant to the Department of Surgery in the Division of Cardiac Surgery at the University of Maryland School of Medicine. After earning his Ph.D. from Johns Hopkins University School of Medicine, Pittenger worked on mesenchymal stem cells (MSCs). He spent more than 10 years at Osiris Therapeutics, including more than two years as the firm's vice president of research. In 1999, he and his colleagues were the first group to provide strong data on the characterization of human mesenchymal stem cells and show their differentiation to multiple lineages. They later showed that the MSCs interact with different immune types of immune cells to down-modulate the inflammatory immune response. Much of his work was translational, performed for the purpose of using these adult stem cells in patients.
ddn: Describe your current stem-cell related work.
Deisher: My work is focused on non-invasive small molecules and biologics to block unintended stem cell sequestration, enabling significantly increased stem cell delivery and retention in target organs.
McErlane: I had a keen interest in the therapeutic potential of stem cells from a targeting perspective during my post-doctorate work with cytochrome P450-1B1 prodrugs, which was further developed during my project work with Genzyme working on a cell therapy initiative in new territories. I am delighted to be able to extend and build on this work at Sistemic, where by aiding the development of safe and effective cells for therapy, I believe the field can really begin to fulfill its immense potential. Recently, I was requested to write an editorial review for this quarter's European Biopharmaceutical Review focusing on the state of the cell therapy industry, and Sistemic's technology at the International Society for Stem Cell Research in Toronto and the Stem Cell Europe meeting in Edinburgh this year.
Pittenger: We are trying to improve the engraftment of stem cells, most notably in the infarcted heart. While the MSCs have multiple abilities that may be beneficial in tissue repair, the low early engraftment limits their potential. Any improvements we find for the engraftment of MSCs will likely be useful for other types of stem cells as well.
ddn: What types of cell lines do you use and why? How do you obtain them?
Deisher: We tend not to work with stem cell lines, although we do periodically work with culture-expanded mixed stem cell populations. We predominantly work with primary mononuclear cell fractions containing multiple stem cell types from bone marrow and whole blood, or with mixed stem cell populations including HSCs, MSCs and VSELs positively selected from mononuclear fractions from bone marrow and whole blood. Additionally, we work with culture-expanded mixed stem cells derived from mononuclear cell fractions from bone marrow and whole blood. We typically obtain fresh cells for each experiment since the types of mixed populations of adult stem cells described above are the stem cells that are bringing the most benefit to patients. This does necessitate long experimental days from start to finish, as the isolation procedures require four to six hours of work.
McErlane: The SistemQC approach we have developed is applicable to all cell types, so we work on somatic cells and also stem cells. Within stem cells, we have worked with iPSCs, hESCs and of course adult stem cells. We obtain cells from our collaborators and/or clients. Our collaborators and clients are a mixture of companies and academic institutions that are focused on using stem cells to develop therapeutics or to develop biologically relevant cell line models for drug discovery and development screening.
Pittenger: We isolate mesenchymal stem cells (MSCs) from bone marrow. They can be isolated by a minimally invasive procedure without sacrificing other healthy tissues, and their expansion in the lab yields millions to billions of stem cells. These MSCs have very reproducible characteristics and differentiate to multiple lineages. We harvest bone marrow from rats, pigs or sheep, and we can order the human bone marrow from commercial sources.
ddn: What are the advantages of using adult stem cells? Embryonic stem cells? Induced pluripotent stem cells?
Deisher: The advantages of using adult stem cells to treat patients, particularly using mixed stem cell populations within mononuclear cell fractions, are: 1) demonstrated effectiveness; 2) availability; 3) patient specificity; 4) lack of immune rejection; 5) affordability; and 6) safety.
Pluripotent stem cells, both embryonic and induced, provide advantages for basic research in the laboratory since they grow irrepressibly and provide ready source material that enhances scientific convenience.
Additionally, induced pluripotent stem cells provide the opportunity to study disease using patient- specific stem cell lines.
McErlane: The advantage of using embryonic stem cells over adult stem cells is their level of ability to differentiate into all cell types of the body due to their pluripotency. Adult stem cells are limited to differentiating into different cell types of their tissue of origin. Another advantage of using embryonic stem cells is that they can be grown easily in culture, in comparison to adult stem cells, which are rare in tissues, making the isolation and expansion of these cells challenging. Since it is likely that large numbers of cells will be required to produce cell therapies for patients, embryonic stem cells have the advantage due to their growth and volume characteristics.
An advantage of using adult stem cells over embryonic stem cells lies in the fact that there is a question of whether embryonic stem cells, once implanted, will cause rejection. Adult stem cells are thought to be less likely to cause rejection. For example, a patient supplying his or her own adult stem cells can be expanded in the laboratory and then re-introduced back to the patient, where the new cells would be unlikely to be rejected by the immune system as they originated in the patient. Not being at risk of immune rejection is a great advantage, as it abolishes the need for taking immunosuppressive drugs over the lifetime of the patient.
iPSCs and ESCs are very similar in many respects, and the comparison between adult and ESCs hold true for iPSCs also.
Pittenger: Adult mesenchymal stem cells have few ethical arguments against their use. They can be easily grown ex vivo, characterized in many ways and formulated for use in tissue repair therapies or limiting immune responses. They are normally found in the adult tissues that need repair, but in insufficient numbers. They have now been safely implanted in more than 1,500 patients. Although embryonic stem cells and iPSCs may provide stem cells for more cell types than MSCs, both form teratomas in vivo, and this problem needs to be carefully solved before they are likely to be safe for clinical therapies.
ddn: Are induced pluripotent stem cells a good alternative to human embryonic stem cells? Why or why not?
Deisher: Induced pluripotent stem cells are a superior choice over embryonic stem cells for studying disease development since they can be disease-specific.
McErlane: An advantage of iPSCs over ESCs is the fact that since the cells will be a near-identical match to the cell donor, rejection by the immune system is thought to be unlikely. A similar potential disadvantage of both iPSCs and ESCs is the fact that both cell lines have the ability to produce teratomasunlike adult stem cellsand this is of major concern to the people working in the field, as at the end of the day, we all want to bring only effective and safe treatments to patients. The iPSC strategy creates pluripotent stem cells that, together with studies of other types of pluripotent stem cells, will help researchers learn how to reprogram cells to repair damaged tissues in the human body.
Pittenger: The iPSCs are a good alternative to ESCs and have many properties of ESCs, but producing them efficiently is still difficult. The iPSCs can be made without the need for integrating vectors, but the process is not optimal. The iPSCs may have limitations on their differentiation owing to their tissue of origin or the adult nature of the starting cells.
ddn: Scientifically speaking, what are the disadvantages or risks of using each of these types of cells?
Deisher: Pluripotent stem cells, including embryonic and induced pluripotent stem cells, form tumors by their very nature, and this tumor formation cannot be eliminated or removed completely either by cell culture differentiation or manufacturing techniques. Pluripotent stem cells also present economic risks as the price of these types of treatments, when they have been publicly estimated, are placed at just under $500,000 (according to a press release by Thomas Okarma, CEO of Geron Corp.).
Additionally, embryonic stem cell therapies present issues of immune rejection. Drugs to counter immune rejection themselves pose risks of diabetes, hypertension and osteoporosis.
In the United States, horses, dogs, cats and donkeys are being treated with adult stem cell treatments. For instance, instead of a $12,000 knee or hip replacement, dogs can receive $1,800 stem cell therapy with equivalent results. If one asked a veterinarian why they are not treating their animal patients with embryonic stem cells, they would tell you that embryonic stem cells are prohibitively expensive, and present dangers of tumor formation and immune rejection.
McErlane: There are some major differences between iPSCs and ESCs worth noting. The genetic manipulation at present that is required to produce iPSCs, and the long-term consequences of this manipulation after transplantation to the patient, is a big unanswered question of the moment. In addition, there are queries around iPSCs maintaining the genetic memory of their origin, and the long-term consequences have also yet to be understood.
Pittenger: Today, I would say that for adult stem cells such as MSCs, the largest disadvantage is the limited engraftment and their limited differentiation potential to certain lineages. For ESCs and iPSCs, the major disadvantage is the formation of teratomas, that is, the lack of control over their growth and differentiation.
ddn: What is your position on some of the current moral and ethical questions surrounding embryonic stem cell research? Has this debate impacted your work? If so, how?
Deisher: Science should never be removed from ethical and moral oversight. History has taught us this too many times for us to now believe that science is above morals and ethics. The Sherley vs. Sebelius lawsuit, of which I am a plaintiff, asks the courts to uphold the laws of Congress and the intent of Congress in passing the Dickey- Wicker Amendment each year since 1996.
McErlane: I personally believe that there are misconceptions surrounding the moral and ethical questions that surround hESC research, especially in the area that not all ESC research causes the destruction of embryos. In fact, there any many other research techniques available now to produce ESCs that do not harm or destroy the embryo, such as single cells from a blastocyst, dead embryos, non-embryo sources of stem cells created using altered nuclear transfer, parthenogenetic stem cells and germ-cell-derived stem cells. It is my belief that it is our job as scientists to educate the wider public on the alternate sources of ESCs, which I believe to some degree would dispel some of the currently popular beliefs held in this area.
Pittenger: I am not insensitive to the issues, but to me, the fertilized egg is not an individual, and in vivo, many embryos do not implant or develop. To me, the ethical and moral questions about undeveloped human embryos pale in comparison to the moral questions of life and death of children and adults everywhere. I believe any embryos that were created for in-vitro fertilization and are in freezers but unused eventually will be destroyed by letting them thaw and then discarding them. I would rather see this resource used for helping others.
ddn: How have these moral and ethical concerns impacted the overall progress of stem cell research?
Deisher: Adult stem cell clinical progress has been impeded in the United States because the polarizing moral debates have hijacked the discussion away from the true interests of patients. Objective analysis, regardless of one's views about the stage at which human life deserves protection, concludes that adult stem cells are the preferred stem cell to treat patients. Effectiveness, safety, availability and affordability criteria all place adult stem cells as the preferred stem cell therapy.
McErlane: These public concerns have impacted the overall progress of stem cell research in some countries more than others, and at the end of the day, it goes back to us educating the public about the types of cells we use, how they are generated and the potential of these types of treatments to improve and even cure patient diseases, as well as lessening the economic burden of healthcare on our economies.
Pittenger: Certainly, this topic has been debated broadly, and could be debated even if stem cells were very successful at repairing tissue and relieving pain and suffering. I think there are technical hurdles that have been difficult to overcome that have delayed progress more than the moral debate, but one never knows if the next dollar spent on the next experiment can solve the problem, and certainly there was a multi-year ban on ESC research.
ddn: How can those who are pro-embryonic stem cell research and anti- embryonic stem cell research find common ground? What discussions must we have?
Deisher: We can find common ground if we place the true interests of patients first and if we have full disclosure about present and future research intentions. If the real goal of embryonic stem cell research is human cloning, and this is not honestly disclosed, then many discussions are seriously hampered.
McErlane: It is all about basic communication, where everyone understands at a basic level the issues we are discussing. Perhaps as scientists, we need to become more adept at translating the theories in our laboratories out to the general public so there is a better understanding of what we do without misconceptions.
Pittenger: The moral and ethical issues may not be easily agreed upon, but there are many scientific questions that can be posed equally for adult and embryonic stem cells. Some of these questions are the practical issues, such as can the cells be grown to large numbers in reproducible manner to provide a well-characterized reliable source for tissue regeneration needs?
ddn: What should the government's role be in funding stem cell research (in any form), or legislating and regulating what types of stem cell research can be conducted?
Deisher: Stem cell research that involves the destruction of human embryos or that promotes human therapeutic or reproductive cloning is justifiably regulated by our elected officials, locally and federally, and by open public debate and votes of the people.
Pittenger: The government is deeply involved in healthcare and therapeutics at all levels: research, development, safety assessment, regulatory aspects, efficacy assessment and recommended best practice. The government should assure the safety of potential cell therapeutic products, and therefore needs to fund research at many different levels. Unfortunately, the government often operates as a non-scientific, political body that reflects views of politicians, rather than scientists and doctors trying to improve healthcare.
ddn: To what extent has the controversy associated with human embryonic stem cell research impacted the public's understanding of science? How can we improve this understanding?
Deisher: As Dr. Art Caplan, an embryonic stem cell proponent, stated in December 2010, "Embryonic stem cell research was completely overhyped, in terms of its promise. And people knew it at the time. I tried to say so myself at different times myself, even though I support embryonic stem cell research. But this notion that people would be out of their wheelchairs within a year if we could just get embryonic stemcell research funded was just ludicrous. Just simply silly. Yes, those saying it had to know it at the time. The scientists had to have known that."
The public's understanding of science might be improved by clearer and more truthful statements from scientists, and by less biased coverage of science by the media, which at times reaches the level of untruthful reporting.
Pittenger: The public's interest in science is very important to assure funding of research and development. Controversy in science leads to more available information on both sides of the arguments, and individuals will then need to become better informed and make their own decisions. Clear, concise information from reliable sources needs to be available.
ddn: In your view, what is the biggest misconception about stem cell research, and what can be done to change that misconception?
Deisher: The biggest misconception is that pluripotent stem cells (which includes both embryonic and induced pluripotent stem cells) are the magic potion for patient therapy. Stem cell treatments to date that have helped patients have all used adult stem cells, predominantly mononuclear stem cell fractions taken from various sources within the patients themselves. Pluripotent stem cells are fraught with safety problems and are years behind adult stem cells, and they may never help patients because of their safety problems.
This misconception will be changed when media and other agents that disseminate stem cell news correctly and truthfully identify the source of the positive stem cell results they are reporting as adult stem cells. Unfortunately, when the news covers stem cell success stories, the word adult is commonly dropped, leading the public to think that the progress was made with embryonic stem cellswhen in fact, embryonic stem cells have not helped anyone. Accurate reporting is not too much to ask of the media, particularly as patients' lives and health are at stake.
Pittenger: I think the first misconception is that it is a long way off; it's not, at least not in every field. The second misconception is that success in applying stem cells to health issues will be "all- curing"it will not. Rather, it will be another powerful tool for treating a variety of health problems.
Root to stem
In new survey, we try to get to the bottom of perceptions on stem cells and other R&D efforts
By Jeffrey Bouley, ddn Managing Editor
Editorial: Embryonic stem cell research: A Dickey-Wicker of a situation
Isn't it about time Congress revisited what is essentially an afterthought on a 15-year-old appropriations bill, clearly articulated the facts and concerns about hESC research and put forth a specific policy on the matter?
By Amy Swinderman, ddn Chief Editor
To view all of the content from our three-part series on stem cell research, click here.
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I use JMP Pro 14.1.0 on a Mac. I want to perform repeated measures analysis of covariance.
In my data there are two grouping variables for subjects, race/ethnic status (B v H v W) and gender (M v F), thus six cells of status & gender.
There are six dependent variables, all derived from a parent-completed rating scale, so the dependent variables may be correlated.
The subjects in each cell vary slightly in mean age, and subject age could possibly affect the dependent variables, so I want to covary on age.
What are my steps in JMP to do this?
I am not entirely clear about the design of the study but try this approach. First, create a data table with a data column for race/ethnic status, gender, age, and the six responses. Enter each response on a separate row. In other words, do not pre-summarize the data by "cell."
Select Analyze > Fit Model. Select the six response data columns and click Y. Select status, gender, and age. Click Macros and select Factorial to Degree. This model assumes the possibility of interactions (e.g., the effect of age might differ between sexes) but no non-linear effects. It is a good place to begin. Be sure to select the Fit Separately option in the upper right corner. Click Run.
See the Help > Books > Fitting Linear Models book. There are several related chapters dealing with these models and the options and results from the Fit Least Squares platform.
thank you. the data table is already set up the way you say, so it will be easy to try. i will examine those references you gave, as well
I am always amazed how Mark provides such good advice with so little input... In any case I have some additional thoughts:
1. What are the "parent-completed rating scales"?. Have you assessed this measurement system? Is there consistency within and between rater? How much variation is there within/between rater? Are you just averaging these ratings? How are you handling rater bias?
2. I'm not exactly sure what you mean by repeated measures. If indeed they are repeats (multiple data points without the treatment combinations changing), they do not add degrees of freedom. So it looks like you will have 5 DF's. As Mark points out, it would be most logical to look for linear relationships (non-linear race/ethic status is illogical) so you will have to "give up" a degree of freedom to estimate the linear effect of the covariate (no interaction).
3. I would typically recommend replicates to add DF's to investigate covariates (you will have both fixed and random effects in the model).
4. Analyze (fit model) the covariate using sequential tests (Type 1) and partial (Type 3) for the fixed effects. Turn on VIF's (add column in parameter estimates) to look for correlation among the predictor variables.
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subset: commoncrawl


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It's Skin Prestige Masque D'escargot is a gel type sheet mask enriched with snail mucin extract and EGF (epidermal growth factor). The combination of the two ingredients moisturizes, treats troubled skin, while regenerating damaged cells which cause aging. The mask effectively manages rough skin to make it healthier, brighter, and more supple.[HOW TO USE]
1.After cleansing the skin, apply the sheet onto the mask.
2.Leave on for 5 to 10 minutes and remove.
3.Pat the remaining formula into the skin for faster absorption.
Water, Butylene Glycol, Glycerin, Snail Secretion Filtrate, Mineral Oil, Paeonia Suffruticosa Root Extract, Chondrus Crispus (Carrageenan), Ceratonia Siliqua Gum, Cellulose Gum, Polyacrylate-13, Methylparaben, Disodium EDTA, Sodium Polyacrylate, Polyisobutene, Polysorbate 20, Fragrance, Phenoxyethanol, Adenosine, Arbutin, Hydrogenated Lecithin, Glycine Soja (Soybean) Oil, rh-Oligopeptide-1


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Ernest Henry Otterpohl was born August 4, 1933 on the family farm near Gann Valley, SD to Henry and Agnes (Larson) Otterpohl. He was baptized at Kimball Lutheran Church. He attended Victory Buffalo School and Peishing West Winge School through the eighth grade.
As a young man, Ernie worked on the family farm. Later, Ernie worked in construction on Big Ben Dam in Chamberlain, SD and he helped build Interstate 90. He drove semi truck and mail truck.
Ernie enjoyed volunteering at the church. He helped Pastor Berggren by mowing the lawn for the church. He also mowed and cared for the Norwegian Free Lutheran Cemetery in Pukwana. While Ernie was driving the mail truck near Sioux City, Iowa, he met Linda Benson while she was working at her family's restaurant. They were married on June 29, 1979, at New Home Lutheran Church in Mitchell. Ernie and Linda lived in Davison County throughout their 37+ years of marriage.
When they moved back to Mitchell, Ernie worked as a mechanic and attendant at several gas stations until retiring in 1985.
Ernie is survived by his wife of 37 years, Linda Otterpohl, and daughter, Emma Otterpohl; two sisters: Adelaide Maiden and Ramona Wendelboe; and many nieces and nephews.
He is preceded in death by his son, Thomas; parents, sister, Lois Sweet; nephew, Calvin P. Sweet; nephews-in-law, David Wendelboe and David McBrayer.


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Roasted pork that was purchased from a Minneapolis market and resold at a street festival was the "likely initial source" of a salmonella outbreak that sickened 80 people in August, a Minnesota Department of Agriculture investigation concluded.
The food poisoning incident has already put the street festival organizer, New York Plaza Produce, out of business and prompted the city to fine the company $1,000 for violations that included the illegal slaughter of guinea pigs for food. Now, state records obtained by the Star Tribune describe how the salmonella was traced to three whole roasted pigs that New York Plaza Produce owner Nieves Riera bought from Shuang Hur BBQ on Nicollet Avenue.
An Agriculture Department investigator determined the pork probably had low levels of salmonella when Riera bought it, but the salmonella likely grew and spread through cross-contamination. The state sent New York Plaza Produce a "notice of warning" earlier this month, a typical penalty for a first violation.
Attorneys for Riera say the market should be held responsible for selling the tainted pig. Khan Huang, owner of Shuang Hur BBQ, said the pork was not intended for resale.
The Department of Agriculture, which licenses New York Plaza Produce, began its investigation after reports of gastrointestinal problems among those who served food at the Aug. 11 Ecuadorian Independence Day celebration on E. Lake Street.
Carrie Rigdon, one of the investigators in the case, said meat purchased at a retail market should not be resold.
"The fact that there was further preparation and serving at the festival, and that it was a multi-hour process, it's likely that any contamination just multiplied" and cross-contaminated rice, beans and guinea pig meat, Rigdon said.
"If not held at the right temperature, you get into this zone where any salmonella is really happy and keeps growing," she said.
Attorneys Boris Parker and Jordan Anderson, who represent Riera and the business, said Riera felt "very distraught" after learning that dozens fell ill at the festival, which she has hosted for several years. Parker said they have statements from various attendees who say they did not get sick from eating her food, and those who did likely ate food that was contaminated before Riera served it.
"Her suspicion was that the issue was with the pork," Parker said. "We are not saying that she could not have been more careful to avoid the problem, but the root cause was not her or her food." Parker said given the bulk of Riera's purchase, Huang should have known the pork was going to be resold.
On Aug. 15, Minneapolis officials visited New York Plaza Produce "and said it does not look like a primary wholesaler (just retail) and it does not look in good condition," said a Department of Agriculture report. The inspectors also found "additional product that had been cooked at this facility in preparation for another upcoming event" in northeast Minneapolis.
"During the inspection, a member of the public had come by to state they had gotten sick from the pork served by Ms. Riera at the August 11 event," the report said.
In an Oct. 8 letter, the department told Huang that "even though you state you were unaware that your retail roasted pigs were being sold at the Ecuadorian Festival it is still a violation … and you are required to make every effort possible to inform your retail customers that they cannot resell your retail processed meat."
Huang said in his 20 years in business, his pork has never been an issue. He said he is "not selling to Ecuadorian customers" because he does not want to risk another situation like this one. He said he thought the three pigs were going to be served at a private party.
In addition to the violation of reselling the pork, Riera was not authorized to slaughter guinea pigs, a traditional Ecuadorian food known as "cuy."
The investigation revealed that Riera purchased two frozen guinea pigs from a Minneapolis store and a dozen guinea pigs on Aug. 8 from Gary Ash in Cedar, Minn. Ash told investigators that Riera purchases 10 to 12 guinea pigs every two or three months. Tests of the feces in the enclosures where the guinea pigs were held tested negative for salmonella, the report said.
After obtaining the animals, Riera "cut the necks of the guinea pigs, drained the blood, removed the fur with hot water and then washed the guinea pigs with cold water," the report said.
Riera's attorneys said they are working to get the city's fine reduced, but she will ultimately pay "whatever is finally imposed." Riera has surrendered the licenses for her business and plans to find a tenant for the closed market's building at 1304 E. Lake St.
"Our client is not running away from responsibility," Parker said.
Twitter: @amatos12


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Living the Dream!
National Children's Book Festival 2016 Fabadoodle Tour. Over 150 children from County Wexford got to meet my Fabadoodles and talk about famous illustrated dogs in children's books. We laughed, sighed, giggled and doodled together until it was time to go home. Dame Daisy managed to keep her nerves in check and the pups were on their best behaviour!


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Mumbai Diary: Tuesday Dossier
The city — sliced, diced and served with a dash of sauce
Funny business
Comedienne Radhika Vaz says it like it is, and still manages to tickle the funnybone.
Comedienne Radhika Vaz
She is out with a memoir, (Unladylike), where she talks about everything under the sun, from puberty and curves to pre-marital sex and being married.
We are hooked to this one, especially since few like Ms. Vaz can make gender issues fun.
On the happiness crawl
With at least one eatery dotting every street of Bandra, a dessert crawl is the stuff of chocolate-lover's dreams. And, a festive crawl means a double whammy.
Guests enjoy hot chocolate and marshmallows. Pic/Satej Shinde
Not surprising then that the Bandra Christmas Dessert Crawl held on Sunday was sold out. From banoffee pies to salted caramel cupcakes and even Chocolate Cranberry Espresso, the guests indulged in seven desserts at many eateries, back to back.
Sipping on hot chocolate and sinking their teeth into marshmallows, they also chilled out at a weekend community festival at the last stop of the crawl.
mid-day and WSD say, go click
With the year coming to an end, The Welfare of Stray Dogs (WSD) is ready with its Heart Of Giving Calendar 2016 that celebrates the power that comes with the act of sharing. mid-day and WSD now bring you an opportunity to be a part of this project.
Week 7 Winner: This frame was sent by mid-day reader Ronette Rodricks. This is a picture of Rickuu, who sits below her office in Khar. "He does not miss a chance to put his paw on me, as seen in this photograph. Malai and ice-cream are his favourite foods. I love is the green collar on his neck," shares Rodricks.
Mail us photos of a friendly street dog or cat from your neighbourhood. Tell us the story behind their name, a touching anecdote, or a special trait. Every week, we will print the best photograph selected from entries received until the end of 2015. The photographer of each winning frame
will be gifted a WSD Calendar 2016.
Email: firstname.lastname@example.com with your photo entries.
Marathi books go online
Here is some good news for lovers of Marathi literature. Last week, Amazon announced the launch of their bookstore dedicated to Marathi books, offering a wide selection of over 5,500 titles.
Readers can look forward to classics like PL Deshpande's book Batatychi Chal
These books range from classics to children's fare and cookbooks from leading publishers and acclaimed authors like PL Deshpande, VS Khandekar, VP Kale. Marathi translations of English bestsellers are also available.
Noor Patel of Amazon India, said, "We are confident that this easy accessibility will encourage not only the avid book readers but also the occasional and new readers to read Marathi books."
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Watch Sandra Bullock Make Jimmy Fallon an Ice Cream Sundae Using Mannequin Arms
We've seen Sandra Bullock do so many things in her acting career: play an astronaut, fall in love with a guy in a coma, and be the world's best sports mom. But Wednesday night on The Tonight Show, we saw her go to new lengths in a skit. New arm lengths, actually.
Fallon asked the Our Brand Is Crisis star if she recalled the Canadian soap opera they were on together called Jacob's Patience. Bullock said she remembered it well and enjoyed it, but a sheepish Fallon pointed out that she was rather difficult to work with during those days. Bullock couldn't imagine why and he said it was because she refused to use her own arms on the show.
"At the time I was a hand model for Ring Pop so I had my arms insured," she argued. But Fallon said it didn't look very convincing when she used mannequin arms, and then the director made the rest of the cast use them as well. Bullock didn't think they looked fake. Fallon showed a "clip" from the soap to settle the argument once and for all.
For the next few minutes the audience roared with laughter as Bullock tried making Fallon an ice cream sundae, complete with toppings and hot fudge sauce, using her fake mannequin arms. It was an absolute mess, but quite hilarious. It got even better when Bullock and her fellow ice cream workers sang Fallon the birthday song, all using their mannequin arms to clap in celebration. See for yourself in the show clip above.


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BEIJING: China, a close ally of North Korea, today expressed serious concern over Pyongyang's plans to step up its nuclear and missile programmes.
China is seriously concerned about the latest developments in the nuclear and missile programmes of the Democratic People's Republic of Korea (DPRK), Foreign Ministry spokesperson Lu Kang said. Lu's comments came after North Korea's deputy ambassador to the UN and its vice Foreign Minister reportedly said that a new nuclear test was under preparation and more missile tests would be conducted on a weekly, monthly and yearly basis.
"China is committed to denuclearising the Korean Peninsula, maintaining peace and stability there, and resolving problems through dialogue and consultation. China's stance on this is unswerving," Lu said in strongest comments against North Korea in the present crisis.
Lu stressed that given the complicated and sensitive situation on the Korean Peninsula, China firmly opposes any words and deeds that could heighten hostility and tension and called on all parties involved to make efforts to ease the tension.
Two days ago Lu welcomed the US to play a positive role in peacefully resolving the Korean Peninsula nuclear issue as US Vice President Mike Pence put North Korea on notice pointing to American airstrikes in Syria and Afghanistan.
"We are willing to work with all parties concerned to achieve denuclearisation and safeguard peace and stability on the Korean Peninsula," Lu said responding to Pence comments made in Seoul. "Just in the past two weeks, the world witnessed the strength and resolve of our new president in actions taken in Syria and Afghanistan," Pence had said, referring to missile strikes in Syria for deadly chemical attack and dropping of the mother of all bombs over IS hideout in Afghanistan.
"North Korea would do well not to test his resolve or the strength of the armed forces of the United States in this region," Pence said.
On April 14, Chinese Foreign Minister Wang Yi said conflict over North Korea could break out "at any moment" and warned there would be "no winner" in any war. "There has been heightened tension between the US, the Republic of Korea and the Democratic People's Republic of Korea. The precarious situation deserves our attention and concern," Wang said, without directly referring to threats of strong retaliation threatened by US President Donal Trump if North Korea resorts to nuclear test.
Lu Chao, director of the China's Border Studies Institute at the Liaoning Academy of Social Sciences, told the Global Times that the latest test, despite its failure, could be another defiant message from Pyongyang that it will not change its tough stance in the face of US pressure even though the failure showed that Pyongyang's missile technology was flawed.


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This article is from the archive of our partner .
After a CBS editor accidentally let it slip that GOP candidates doing better in the race would, naturally, be given more of a chance to speak during televised debates, we've charted candidate speaking time against their airtime in Saturday's CBS/National Journal debate. The issue was brought to light by an accidental "Reply All" from CBS political director John Dickerson over the weekend. He emailed a colleague about a post-debate follow-up CBS would conduct with candidate Michele Bachmann, "Okay let's keep it loose though since she's not going to get many questions and she's nearly off the charts in the hopes that we can get someone else," according to CNN's Political Ticker blog. Of course, a spokesperson for Bachmann happened to be CC'd on the email, and her campaign was furious over what it called CBS's premeditated media bias. (CNN's Howard Kurtz, for one, defended CBS time-management policies for debates.)
All of which led the blog Mediaite to crunch the numbers to see if CBS really did give more airtime to top candidates. Nando Di Fino combed through the debate transcript and counted the number of words each candidate said during the debate. Charted below are the results, with each candidate's percentage of Mediaite's word total from the November 12 debate in light red and that candidate's current support in the polls according to Real Clear Politics in a dark red.
The conclusion: a correlation exists, but it's not that strong. As we see above, if a candidate's dark red bar is longer than the light red one, that means by CBS's logic that candidate isn't getting as much airtime as his or her poll numbers would justify. The candidates that got less speaking time than their poll allocation by wide margins are just two: perpetually shunned liberatarian Ron Paul and the much-spoken-about-of-late Herman Cain. Bachmann actually falls in the category of candidates who spoke much more than their polling would allocate: she's got only 4.1 percent of the primary electorate's support, but consumed 9.1 percent of all words said during Saturday's debate. Also among the over-allocated candidates are Rick Santorum (15.1 percent of the words vs. 1.9 percent in the polls), Jon Huntsman, and Rick Perry. Mitt Romney and Newt Gingrich's percentages were actually pretty closely matched.
This article is from the archive of our partner The Wire.
We want to hear what you think about this article. Submit a letter to the editor or write to email@example.com.


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Pricing is probably one of the most difficult aspects of the marketing plan for a small business yet the most crucial, if a profit is to be made. It may be particularly difficult for women in business, because we seem to struggle more with our personal 'worth' in an economic world than men do.
That, however, will have to be the subject of another article. This one will assume that you are 'beyond all that,' and prepared to price your product or service based on established business practices – without guilt or apology.
There are two general ways to approach pricing. Both are equally valid, but for completely different reasons. In order to determine which road you will take, it is necessary to understand the assumptions and logic behind both of them. And regardless of which avenue you choose, each includes some elements of the other one.
The two most common pricing methods are:
— Cost pricing
— Market pricing
COST PRICING. In order to determine the formula you'll use for cost pricing, two kinds of costs must be taken into account:
— FIXED COSTS – the costs that generally don't change over the course of a year (labor rates, insurance payments, rent, equipment leases, etc.)
— VARIABLE COSTS – these are costs that are more difficult to determine over time, such as raw materials or supplies, and advertising costs.
In order to best illustrate cost pricing, I'm going to lead you through a real-life example from my business history. "Once upon a time," I owned a balloon store in a local mall. I retailed party supplies and novelty gift items, and provided a decorating and party planning service, but my 'staple' was a basic balloon bouquet, and I had to determine how to price it.
The balloon bouquet consisted of seven latex balloons and one mylar (foil) tied together with ribbon to a weighted base. Follow me now as I lead you through the pricing process…
Latex balloons come in packages of 144 (12 dozen, called a 'gross' of balloons). Let's say that the average cost of a gross was $20. Seven balloons would only be 1/20 of that cost, or a total of $1. The mylar balloon, on the other hand, was more expensive – the average cost of a single foil was $1.30.
The helium to fill the balloons was another story – by dividing the cost of a tank of helium by the number of balloons it would fill, I determined that my helium cost per balloon was about $.50. Eight balloons at $.50 equals $4 worth of helium.
Then I need ribbon to tie them all together. By dividing the cost of a spool of curling ribbon by the number of balloons I could tie up per spool, I determined that each bouquet's ribbon cost was ten cents.
Let me diverge here for a moment, and talk about this ten cents. You may say to yourself, "Oh, for heaven's sake, I'm not going to take every darn dime into account." Well, I'll tell you what – if I sell 6 balloon bouquets a day, 6 days a week, 365 days of the year, and I don't take that dime into account, at the end of the year I would have thrown away $131.40! Are you willing to do that?
Okay, back to the balloon bouquet. I just need one more thing now to complete it, and that's the weighted base to hold it all down. I used a variety of weights, depending on whether the bouquet was for a child's third birthday, or for a centerpiece at a very posh wedding. I always purchased weights by the carton (or in some form of 'bulk'), and my average cost per weight was $.50.
So … how much has it cost me to put together this basic balloon bouquet so far? Looks like $6.90 to me!
Now I have to determine labor costs. In order to do that, I have to take into account two things:
–What am I worth?
— How long does it take to make a balloon bouquet?
I decided that I was worth $12 per hour, and I knew that I was capable of putting together 6 balloon bouquets per hour. So what was my total labor cost for one balloon bouquet?
If you said $2, you're catching on! So now the cost of the balloon bouquet has risen to $8.90.
But wait – I have overhead expenses! Rental on my little shop at the mall, all-inclusive, was $1000 month. (And this was ten years ago!) In order to make each balloon bouquet pay its share of my 'piece of the rock,' I had to determine two things – how many balloon bouquets I would sell in a month, and what percentage of my total business consisted on balloon bouquets.
My calculations determined that fully 50% of my over-all business came from balloon bouquets – so they needed to pay for 50% of my rent cost. In other words, $500. And, as I mentioned earlier, I sold (approximately) 6 per day – at 31 days per month, that's 186 bouquets monthly. If you divide $500 by 186, you'll discover that the 'overhead' cost to be added to each and every balloon bouquet was $2.15.
Still with me? If so, you know that the cost of that balloon bouquet has now risen to $11.05.
I'm not done yet. Now I have to determine an approximate cost for all my other fixed and variable business-related monthly expenses – car insurance and fuel, taxes, freight and delivery expenses, etc., etc.
I calculated that all other biz-related monthly expenses came to $375, of which those balloon bouquets had to pay half, or approximately $1 per bouquet.
So the final cost calculation for a single balloon bouquet comes to $12.05.
Now here is another place where women tend to err in their pricing decisions. We are tempted, now, to sell that balloon bouquet for about $12, because we've even taken into account a generous amount for our labor.
We'd be sorely cheating ourselves if we do. Indeed, $12.05 is simply the break-even price for that balloon bouquet.
I don't know about you, but I went into business to make a PROFIT. I've made the investment, I put in the long hours and the sleepless nights, I take the risks – I deserve a profit! If I just wanted to make a wage, I can go to work for someone else!
Besides, particularly if your business grows to the point where you decide to hire help (as mine did), then you need to cover that labor cost – it's not going in your pocket then, AND you have the added responsibility of an employee.
So … would you like to guess at what I sold that balloon bouquet for now?
Every industry has a "mark-up," which is dictated by several factors – some of which we'll look at more closely in a minute. I decided to make my mark-up 75% — so the balloon bouquet retailed in my store for $21.95, giving me a gross profit of $9.90 per bouquet.
Sounds good, doesn't it? That means that I made a clear profit of $1675, monthly, on those balloon bouquets. With no apologies or guilt. Know why? Because most self-employed folks don't have medical (or even sick leave) coverage, or pension plans, or daycare subsidies, for example. And remember – it was my investment, and my risk. And my business prospered.
Market pricing.
Notwithstanding the cost formula outlined above, another method for calculating price for goods and services is simply by determining "what the market will bear," or market pricing. Market pricing takes several factors into account:
Product availability. Simply put, if you are the "only game in town," you can charge more.
The economy. People with more money to spend, spend more money.
Perceived value. If people assume your product is worth more than someone else's, they'll pay more.
Remember a few years ago, at Christmas, when parents all over the planet were desperately seeking "Talking Elmos" for their little darlings for Christmas? Well, based on the cost price formula above, Talking Elmos might only have been worth $25 – but because of availability (they were suddenly scarce) and perceived value, they sold for over $60, as I recall.
Essentially, based on market pricing theory, if people were not willing to pay $21.95 for my balloon bouquets, then all the cost formulas in the world wouldn't have mattered. On the other hand, if you have a product or service that is unusual or unique, you can probably price it according to what the market will bear.
For example, during the time I owned that balloon store, I also planted pink flamingoes on people's lawns in the middle of the night – a practise that was all the rage in the early 90s. The community I lived in LOVED this idea, and because they knew that I had to be up at 3 a.m. to pull it off, they gladly paid LOTS for that service. Based on cost pricing formula, I should have charged about $35 for the service. Based on market pricing, I charged $85 – and never once had a shortage of customers willing to pay! And I charged that without apology or guilt – because at 3 am., I was taking risks that no one else in the community was willing to take!
There are many other factors that may effect your pricing decisions – amount of competition, customer loyalty, seasonal variations (ever notice how the price of a dozen roses goes sky-high at Valentine's?), but all of them will still boil down to those two main pricing processes, or a combination of the two – either by cost, or according to the market.
Good luck with your pricing decisions – and don't apologize or feel guilty once you've determined them!
Author Marilyn Guille owns Comprehensive Virtual Editing (CoVE) Services, which provides press release writing and distribution, general and business writing, editing, and ghostwriting services. Guille has been a professional freelance writer for two decades, and lives on a classic boat on which she and her husband do sightseeing charters. You can check out her website at http://www.coveservices.net


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4 bedroom villa near Sotogrande with panoramic sea views on large plot with swimming pool
This fantastic villa is in a central location close to local amenities in Torreguadiaro, with outstanding panoramic sea views over the Mediterrainan sea and Gibraltar.
Renovated by the existing owners, the villa consists of a large salon with separate dining area where the incredible views can be enjoyed, and which leads on to the living room and TV room area where an open fireplace is on offer for the winter months. On this level is also the spacious dine in kitchen and three bedrooms including the master en-suite.
At garden level is a self contained apartment which offers a further bedroom, bathroom and kitchen room, but could be easily converted to provide a further 2 guest bedrooms should this be necessary.
The plot is south facing with ample space for outdoor entertainment and the swimming pool is located away from the main house in a secluded and private area.
The local beaches and amenities are within walking distance and the property.
Sotogrande is an area of outstanding natural beauty and has remained unspoilt due to the low density development of the estate. It is home to some of the most exclusive and luxurious villas on the Costa del Sol and offers spectacular mountain and sea views along with one of the most iconic views to be found in Europe with the Gibraltar and the North African coastlines frequently on display along the horizon.
It is also home to 5 of the most exclusive golf courses on the Costa del Sol including the Valderrama Golf Club, home to the European Tour's Volvo Masters, and the Real Club del Golf which is the oldest and one of the most impressive golf clubs in Sotogrande (and Spain).
Furthermore, Sotogrande boasts 6 world famous polo fields and hosts regular polo tournaments throughout the year attracting players and supporters from around the world, particularly from Argentina which has a large influence on the local cuisine!
Along with 2 tennis and padel clubs, a rugby club, a sailing club, stables, Sotogrande International School, and very popular marina with magnificent beaches all of which is only a 25 minute journey from Gibraltar International Airport & 60 minutes from Malaga Airport, Sotogrande is truly one of the most exclusive destinations in Europe.


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Haute Couture Paris
Daily updates from Centurion Magazine's contributors worldwide
Impressions from Paris for Haute Couture week, as reported by Avril Groom.
Day 4 – 27 January.
Valentino. The best is last, possibly the world's most beautiful clothes. Fortuny the inspiration, so Grecian pleats of exquisite fineness toughened with scrolled gold harnesses, or dark, faded velvet stencilled in old gold. Metallic snake tiaras and enveloping embroidered coats have a pagan, regal ring. Perfect in every detail.
Viktor and Rolf. Couture's favourite performance artists continue exploring wearable art. Last season's framed canvases become this spring's sculpture, all white with hand-constructed Cubist faces, padded hair and cut-out breasts. From Picasso to Brancusi in inspiration, the concept is remarkable but wearable, it is not.
Jean Paul Gaultier. Still the enfant terrible at sixty - his models smoke, drink and have fun on the catwalk - quelle horreur! 1980s clubbing nostalgia, but nowadays in sumptuous silk, velvet or sequin pyjamas or a lace-trimmed slip - quite the trend - plus a good tux suit and an orange mink bomber.
Elie Saab. Younger, cooler look from the master of red carpet pretty glamour. Festival girl short skirts, tiaras and flat boots, sweet long dresses with Victoriana hints, but all in twinkling, crystal beaded lace - silver grey, soft blue or dusky pink. Very grand even if worn with casual hair and make up.
Franck Sorbier. Musée Guimet (Oriental antiquities) for Sorbier's art/fashion fusion, with Indonesian gamelan accompaniment and dancers modelling featherlight dresses in handmade lace and chiffon and washed earth colours. Couture to literally dance in.
Maison Margiela. John Galliano continues his fashion rehab here in fine style. Trenchcoats, bomber jackets and bias-cut dresses link couture crafts of handweaving, patchwork and beading with recycled T-shirts , paper and wood alongside silk and brocade, in magnificent historic setting of Les Invalides.
Day 3 – 26 January.
Alexandre Vauthier: the only couturier who can make bondage kit look classy. Very short, black and cut-out can work on runway bodies, especially worn with thigh boots laced wickedly up the back. Yet with severe, brass-buttoned tailoring it looks wearable, likewise softly ruffled, split-to-here chiffon gowns in dusky khaki or vivid red, spiced with leather harnesses. For very sophisticated good time girls.
Armani Privé. Giorgio Armani's couture collection is in gentle and youthful mood, with fragile fabrics in pale blue, lilac and grey, with black for a little edge. Ruffles and pleats abound, but on graphic, predominantly short shapes. Tiny pleats come in waves like sand ripples, crystal beading and sheer metallics sparkle delicately. All about exquisite work and subtlety.
Bouchra Jarrar. Cool couture for a new generation, with a more Antwerp than Paris mindset. Faultless tailoring, oversized and layered jackets, slinky satin dresses and a "fur" coat in feathers and pearls.
Lydia Courteille. Brilliant Paris independent jeweller takes inspiration from Ethiopian landscape and culture for extraordinary pieces based on volcanic acid lakes, relics in underground churches and the Queen of Sheba. Wild, in every sense.
Roger Vivier Rendez Vous. Historic French shoe brand widens its premium range to include exquisite beaded lace, and the most bling-tastic skate shoes ever. What we need for Paris trekking in today's taxi strike.
Boucheron. Classic Parisian high jeweller adds to its magic animals collection with extraordinary ear climbers of lacquered rock crystal and amethyst, and diamond and pearl peacocks encased in clear crystal pendants.
Aouadi. New, Algerian-born couturier worked with Riccardo Tisci at Givenchy and it shows in fine-boned corsets, delicate button detail, techno-silicon lace and a dress of feather tweed.
Chanel. Karl Lagerfeld's zen-meets-Palm Springs eco-set inside the Grand Palais blends the original, loosened off early 1920s Chanel silhouette with a longer, linear modernity. Simple shapes and restrained colours allow concentration on finest pleating and serious beading.
Day 2 – 25 January.
Alexis Mabille. Ultra-feminine, but masculine codes - hourglass tuxedo dresses, satin trenchcoats dressing-gown soft, dinner suits over loose shirts with sparkly lace. Plus balletic lace and tulle, and ex-super models still looking great.
Giambattista Valli catches the early 1960s spirit better than anyone, with ritzy couture finish. Tiny dresses mixing draped silk and sparkle tweed, barely-there baby dolls, blossoms beaded or embroidered, and a cloud of tulle ruffles. We loved the soft sheepskin underfoot.
Ralph and Russo. Grand red carpet gowns, London-made with Parisian embroidery. Phalanx of clients including Uma Thurman and Rita Ora loving soft pastel embroidery, spun gold leaves on nude and a duvet's worth of feathers. Goes from exquisite to OTT.
Del Pozo. Likewise this hotter than hot brand, made in Spain to almost-couture standards. Big, bright wonderful fabrics from stiff brocade to featherlight pleated tulle, decorated with sequin flowers. Great colour-blocked bags too. A name to watch.
Miu Miu. Not couture but early autumn ready-to-wear. 1970s-influenced, long A-line coats in "off" shaded jumbo cord and checks, with lace or sequin collars, chunky knit skirts and socks, with thick-heeled shoes patterned with studs. Part of the new, maximal-geek, quirky tendency.
Dior. Bereft of a designer name for the second time in five years, the seven-strong in-house team do a good job with the brand's codes - curvy tailoring, ultra-feminine frocks - and find some new direction. Longer, slimmer tailored lines, off-shoulder layering, super-size ruffles and slightly 1930s sheers figure prominently.
Dice Kayek. Architectural shapes, sculpted cutting and big, clean lines from Turkey's star designer sisters. Oversize sleeves, faintly military details in buttons rows and crystal epaulettes. Fabrics a little warm for summer by the Bosphorus.
Chanel high jewellery. Quilting symbol takes over in white gold and diamonds, rock crystal, black pearl and some stonking sapphires. Every element curved and tactile, mystery-set sapphires the best of work.
Schiaparelli. Elsa Schiaparelli loved Surrealist food, played on by designer Bertrand Guyon to make wearable magic. Sequin fruit and vegetables, plus the famous lobster, ornate embroidered plates, intricate basketwork capes. Shocking pink goes neon. All airy light and very wearable.
Day 1 – 24 January.
Versace. White space, modernity and strong woman clothes. Monochrome tailoring spliced with vivid blue, orange or neon yellow. Cut -outs and sparkles as usual, optical lines like glittering cobwebs and non- size zero models looking fabulously sexy.


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Turisme actiu, activitats culturals, esdeveniments esportius, itineraris guiats a la natura ... Si vols gaudir de múltiples activitats a les comarques de Barcelona, no et perdis aquestes oportunitats!
From 10.30 a.m. to 12.00 p.m., dive into the world of trains with a VIP tour of the Museu del Ferrocarril de Catalunya; a world of technology and precision, but also of emotions and memories. The Museum is located in the original facilities of the steam locomotive depot of Vilanova, a railway buildings straddling the 19th and early 20th centuries.
Be prepared to go to Sitges from 11.30 a.m. to 11.45 a.m., a town in the Garraf region which has 4 km of beach.
From 12.00 p.m. to 2.15 p.m., immerse yourself in the town centre where you can see the Cau Ferrat (museum housed in the Modernist home and studio of Santiago Rusiñol), the church of Sant Bartomeu and Santa Tecla, the shopping area, etc.
From 2.30 p.m. to 4.30 p.m., enjoy a waterfront seafood meal in the prestigious Picnic restaurant.
From 4.30 p.m. to 5.30 p.m., be mesmerised on the Sitges seafront, where you will see Indian mansions on one side and the sea on the other.
At 5:30 p.m., relax and go back to the departure point.


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Mini Magic Crystal BallRUNNING PRESS
Unlock the mystical power of a fortune teller with the Magic Crystal Ball. Wave your hand over the glass crystal ball to reveal one of 15 "answers" to put you on the path to fulfilling your dreams and finding happiness.
Kit includes:
A mini glass crystal ball with motion-activated light (glowing aura) and sound (music and mystical answers).
A black base.
A 48-page mini book, with a brief history and tips on how to use your crystal ball.
Product details
Paperback, 48 pages.
Product Dimensions: 3" x 2" x 3.8"


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2009. 8. 16. 03:17 Social Network Services
Google News Alert for: online social network
Dassault Systemes and blueKiwi Software: A Joint Vision of Social ...
FOXBusiness - USA
Social Innovation is about connecting individuals, ideas and virtual experiences, and leveraging social networking capabilities. We have imagined online ...
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Commentary: Twittering journalism
United Press International - USA
Inconsequential social networking became instant social mobilization -- and sources of reporting for television networks whose correspondents were ordered ...
See all stories on this topic
This as-it-happens Google Alert is brought to you by Google.
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Fourth of July: Celebrate Bossier-Shreveport Heroes
America celebrates her Independence Wednesday, and along with the barbecues and the picnics we remember the fortune of freedom. Local civic leaders are marking the day as one of the most important holidays Americans observe.
Bossier Sheriff's Lt. Bill Davis served in the United States Navy overseas when 9-11 happened.
"The ability for us to go to churches where we want to go, out to eat where we want to, have this immense freedom in this country...
Go to a foreign country where you don't have those freedoms, and you'll appreciate it. You'll come back and kiss this great land we live in.
Lt. Davis served as a correspondent in the Navy and wrote stories about heroic military men and women, who help protect our freedoms.
Davis told KEEL he enjoys working with Young Marines, a youth education and service program f;or boys and girls. The organization helps build character in youngsters and teenagers, both morally and physically.
The Bossier Sheriff's Office sponsors Young Marines, and the program is free and available to all Bossier Parish youth.
Davis says he understands the importance of instilling patriotic and family values to the younger generation because they become the heroes of tomorrow.
"It's those firefighters, those law enforcement officers, who are working day in and day out around the clock to preserve the freedoms we have right here in our community in the ArkLaTex. And that's a great thing to know that we are safe because of men and women who have said I'll answer the call to protect us."
Davis enjoys the wonder of "small areas where you 'do' have the volunteer fire departments and you see the folks and they may live right down the corner from where you're protecting that fire, or working that scene. Folks know each other so they're taking care of one another and that's always a good feeling when you know you're helping each other out."
He says he's proud to celebrate July Fourth, raise the flag and say " this is the greatest country and we should never take those freedoms for granted because of men and women who fought before us and who are continuing to fight this day around the country, around the world and right here in the ArkLaTex.


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Advocates In Tetri Bazar
Get free legal advice from the Best lawyers in Tetri Bazar. Hire the Best Law Firms for your Legal issues. Lawyers in Tetri Bazar are listed here,to provide fast,cost effective legal services in Tetri Bazar. Here you will get Best Advocates in Tetri Bazar for your legal issues. immigration lawyers, litigation attorneys, injury lawyers, employment lawyers, family law Advocates, Top Lawyers In Tetri Bazar are available here.


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|Sighting Report
|Occurred : 11/23/2011 22:45 (Entered as : 11/23/11 22:45)
Reported: 11/23/2011 8:27:09 PM 20:27
Posted: 12/12/2011
Location: Charleston, WV
Shape: Triangle
Duration:10 seconds
|V shaped, silent fast moving orb formation.
Appeared to be a "string" of perfectly, evenly spaced round shapes in a triangle formation. Moving quickly and silently North to South.
No lights, but the shapes were illuminated by the light pollution from the ground. Around the same distance from the ground as the small personal aircraft I see flying around here from the local small airport.
I have never seen anything like this in my almost 49 years on Earth!


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Proposed Flat Brook Year Around Trout Conservation Area
Update October 2011: Approval for the TCA has been slow coming as not all are happy with the addittional regulation that the TCA would bring to the Flat Brook. It now looks like nothing will be happing before 2013.
Duane Lloyd // JSTU
The Fred S. Borroughs North Jersey Trout Unlimited (FSBNJTU) Chapter is embarking on a project to establish a Year Around Trout Conservation Area on the Big Flat Brook. The proposed Year Around Trout Conservation Area, will be from the end of the Blewett Track to Roy Bridge, about 1.5 miles. My understanding this will not be a Fly Fishing Only restriction so Spin fishers may also enjoy the fishing here.
For those who are not sure just where the Big Flat Brook is, it is in Sussex County in the Roy Wildlife Management Area and the fly fishing only part is commonly known as the Blewett Track. The Blewett track begins at the Three Bridge road and ends upstream of the junction of the Big and Little Flat Brook. According to Allen G Eastby in my copy of "New Jersey's Fishing Streams and the Delaware River" the Flat Brook is actually three very distinct trout stream.
The Fly Fishing Only stretch starts at the route 206 bridge and extends down stream to the Mountain road bridge. Another stretch known as the Blewett begins at the Three Bridges road for about one half mile to the junction of the Big and Little Flat Brook. The remainder of the stream is open to the use of spin and bait fishing. Good fishing continues all the way to the Delaware River. The Big Flat Brook bears close resemblance to trout streams in nearby Pennsylvania, clear cold and unspoiled.
The FSBNJ TU will be conducting a stream survey, with the design firm Urbani Fisheries to define what needs to be done. The design firm Urbani Fisheries will use a set of techniques called "bed manipulation". This involves reorganizing the native elements in the stream to favor trout and their food based organisms. The object is to develop deep pools, riffle and run habitats and establish thriving native riparian vegetation communities along stable stream bank and flood plain areas.
The FSBNJ TU will be planting trees near the three Bridges access area in Sept or October. Help is always welcome and this would be a chance to get your good guy points and see the river, up close. Watch for scheduling details and bring: shovel, gloves, work boots, 5 gal; spackle bucket. For more information, call FSBNJ TU Member Glenn Zeeck, 908 753 7065.
Information for this taken from;
New Jersey Trout with John Punola
New Jersey Fishing Streams and the Delaware River -Allen Eastby
Fred S Burroughs North Jersey TU Chapter News Letters


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Highland Park is a Western Suburb of the Gold Coast on the Western border of the motorway West of Carara. Are you in Highland Park and trying to locate a nearby Locksmith? Well, you've found them in All Coast Locksmiths Highland Park. Allcoast Locksmiths have been offering a first class Locksmith service in Highland Park for almost twenty years.
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text:
A major component of the evaluation of reports of suspected adverse drug reactions, or events in a clinical trial, can be a judgment about the degree to which any reported event is, in fact, causally associated with the suspected, or investigational drug. In reality, a particular event is associated or is not associated with a particular drug, but the current state of information almost never allows a definitive determination of this dichotomy. (Jones 1994)
The analysis of causality and association in adverse drug events has not changed in the last 20 years. Riddell (1983) describes the "ways and means" of confirming or denying the possibility of an ADR which constitute a validation process that removes suspected cases from the merely anecdotal category. They are:
- Temporal eligibility – drug must be administered at some interval of time before the reaction occurs.
- Latent period – There is an interval from the time at whcih a drug is first administered to the beginning of the ADR.
- Exclusion – are any other drugs or existing conditions responsible. This method is not applicable in all cases of possible ADR, either because of insufficient data or because of simultaneous eligibility of more than one drug.
- De-challenge – condition improves on discontinuation of the drug, and
- Re-challenge – condition reoccurs upon re-exposure to the drug (usually not deliberately, since a suspicion of an association with an adverse event would preclude intentional re-exposure of a patient to the same adverse event.
- Singularity of the drug – Is there something unique about the adverse reaction experience that is not consistent with any other drug taken or any existing disease condition.
- Pattern – ADR been described in the literature with this drug or another in the same pharmacologic class, or it may refer to a morphologic pattern in a target organ that suggests an association with a particular drug or group of drugs. (Prior history with Hypervitaminosis A provides a literature precedent, a biological plausibility).
- Drug Identification (qualitative or quantitative) – a major utility in overdose cases.
Hill Criteria for Causation
- 1. Strength of association
- 2. Consistency of results
- 3. Specificity
- 4. Temporal relationship
- 5. Dose response
- 6. Biologic plausibility
- 7. Biologic coherence
- 8. Experimentation
- 9. Analogy
Causality assessments were usually expressed in terms of a qualitative probability scale, for example "definite" vs. "probably" vs. "possible" vs. "doubtful" vs. "Unrelated." (Hutchnson1989)
Hill Criteria – Expanded Discussion
1. Strength of Association
• A strong association gives support to a causal hypothesis
• A weak association requires other information but can be equally as important
2. Consistency of Results
• Repeated findings in different populations and different settings
3. Specificity
• Strengthens confidence in association.
• Lack of specificity does not rule out causation
4. Temporal Relationship
• Required: exposure most come before disease
5. Dose Response
• Increased dose = increased risk
• Holds for drugs and vaccines (doses)
6. Biological Plausibility
• Known mechanism not required.
– Cigarettes and lung cancer
– Asbestos and lung cancer
– Fen-Phen and valvular heart disease and PPH
7. Biological Coherence
• Does not conflict with what is known
8. Experimentation
• RCT is close to experimentation.
• Removal or reduction of exposure reduces disease.
• Challenge – dechallenge – rechallenge
9. Analogy
• Similarities with other like exposure
– Aminorex and PPH
– Ergot drugs and VHD
• Learn from past mistakes
• Temporal relatedness
• Known or reported AE of Medication
• Presence of Concurrent Illnesses or medications which could present similarly
• Challenge – Dechallenge – Rechallenge
Submission Of ADR Reports
ADR reports often paint an incomplete picture as the cases which are filed each year represent only a fraction of actual cases. According to the UK MCA only 10-15% of serious ADRs are ever reported. A FDA MedWatch Continuing Education article (Goldman et al 1996) describes significant underreporting in the United States. He cited estimates that rarely more than 10% of serious ADRs, and 2-4% of non-serious reactions are reported to the British spontaneous reporting program. A similar estimate is that FDA receives direct reports of less than 10% of suspected serious ADRs This means that cases spontaneously reported to any surveillance program, which comprise the numerator, generally represent only a small portion of the number that have actually occurred. The effect of underreporting can be somewhat lessened if submitted reports, irrespective of number, are of high quality.
Under regulations a pharmaceutical company must submit all ADR reports to the FDA periodically (at least annually) or on an expedited basis within 15 days of receipt. The FDA, on January 5th 1998, sent a warning letter to Hoffman-LaRoche (New Jersey) for failing to submit a number of adverse drug experience reports that were both serious and unexpected, within 15 working days as required by regulations (21 CFR 314.80 (c)(1)) as recently as October 1997 (with some dating back to 1989)(Scrip 1998). The letter documented, among others, two ADR reports for Accutane which were received by the manufacturers on 9/04/91 and 7/24/91. Both reports were not received by the FDA until 10/8/97 (FDA/Middelkoop personal communication). In one case, for Tigason, the company reported the adverse drug event almost 11 years after receiving the information. Thus, although regulations require it, sometimes even the companies do not report in a timely basis, if at all. (Middelkoop, 2000)
Goldman SA. Limitations and strengths of spontaneous reports data. Clinical Therapeutics Volume 20, Supplement 3, 1998, Pages C40–C44
Hutchinson TA, Lane DA. Assessing methods for causality assessment. J Clin Epidemiol 1989, 42: 5-16.
Jones JK. Determining Causation from Case Reports, in Strom BL, Pharmacoepidemiology, Second Edition, Wiley, New York, 1994, at page 365.
Riddell RH.,ed. Pathology of Drug-Induced and Toxic Diseases. Churchill Livingstone, New York, 1982 (3-9).
Marks DH. Evaluation of Medical Causation, in Drug Injury: Liability, Analysis and Prevention, Fourth Edition, ODonnell JT editor. L&J Publications, 2016


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Another one of my stash busting projects. I wanted to use up all of this yarn, which I dyed ages ago. I wanted to make fingerless mittens but to use up all of the yarn, I knitted them top down.
Also, I think I reinvented gravity because these mittens are hanging on this wall without anything holding them up. There are no nails or hooks or anything. I put the mittens next to the wall, thinking they would look good there but I had nothing to attach them. To my amazement, they stayed, just like that. Hurrah for weathered wood.
I knitted the cuffs as long as I could. I suppose they would look best bunched up. The yarn is Novita's Florica, 100% wool. I knitted them with 2.5mm needles. Can you see the snowshoes below? Yup, this is another project I photographed end of winter and then forgot all about them. Snowshoes are kind of essential if you go off the beaten track here in winter. Or, not essential as such, but it's just very hard work to walk without them if you sink down to your thighs with every step. Anyway, enough about winter – it's summer now! Well, sort of.
I'm very pleased with these and happy to have another little bundle of yarn less in my stash.
Happy knitting!


text:
Xiaomi Redmi Note 6 Pro lowest price in Pakistan is Rs. 30,499. The price was updated on 19th October, 2020. You can read price, specifications, and reviews on our website.
The overall rating is based on review by our experts
Please post a user review only if you have / had this product.


text: Sometimes user need to change foreign key attribute value in ADF table's master detail relationship. If you try to change master table's foreign key value, you'll get the following integrity constraint error message. ORA-02292: integrity constraint (JAGRANDB.SYS_C00162401) violated – child record found Download Sample Code To resolve this issue, if user want to change a foreign ... Read More »


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zero-waste home in California. And while I think this is pretty extreme, it has highlighted some simple things I can do to cut waste at our house.
I've already read "Gorgeously Green: 8 Simple Steps to an Earth-Friendly Life" and I have Sophie Uliano's second book "Do It Gorgeously" on my list of books to get. And both of these books helped with brands and companies that are eco-friendly - but the problem tends to be the price tag on such items.
One thing I've already started to do: Go to the Farmer's Market under the freeway here in Sacramento every Sunday morning. I bring my own bags and even my own produce bags so I don't have to use any of the plastic bags. These Flip and Tumble Reusable Produce Bags are only $10-$11 on Amazon for 5 bags and they are great at keeping fruits and veggies fresh. Totally worth the purchase if you are interested.
The Sunday morning Farmer's Market here in Sacramento is amazing. If you plan it out you can get everything you need for the week - which means you are only buying local. Something I really support. I like it better then those CSA boxes because you choose what you want - plus they sell, fish and meat and oysters - even milk, orange juice, cheese and butter.
I'd love to start getting beer and wine in refillable containers, like the growlers at Pyramid. If I find a local winery I like that does that - or takes back the bottles... that would be awesome too.
Anyways, the point is that little things I am willing to do - but if its difficult or not fun - then maybe not.
And one of the things I really don't agree with is the getting rid of knick knacks, etc. I'm a huge antique fan and think its got to be better to reuse - then buy new right? I guess the point is to love what you have and don't buy something just to be purchasing.
I'll keep sharing things I'm doing to cut back on my waste. And I'm open to suggestions!
I'm also hoping to post soon about my finds at the farmers market and do a little comparison to the grocery stores. So look for that post soon!
Friday Fixation: Cutting Back on Waste
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Model Output Discussion 19th January 2014-18z onwards.
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Storm Barbara arriving later as Autumn proper kicks back into gear
After a very wet 24 hours for the north and particularly northwest of the UK, along with Ireland, it's similar areas in the firing line today. From tonight and into tomorrow, southern and central England will also get in on the act as Storm Barbara (named by the Spanish Met Office) moves up from the continent bringing wind and rain with it. Read the full update here
Turning increasingly unsettled and windy next few days, but also milder
Areas of low pressure moving in from the southwest will bring spells of rain and windier conditions across many parts over the next few days, but it will turn milder too Read the full update here
Our picks
Early run up to Winter 2020/2021 discussion
Mapantz posted a topic in Weather Discussion - Autumn,Winter is drawing ever closer, and speculation is increasing - cold and snowy or mild again?
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text: My own view is that augmented reality is the larger of the two, probably by far, because this gives the capability for both of us to sit and be very present talking to each other, but also have other things visually for both of us to see," Cook said. "Maybe it's something we're talking about, maybe it's someone else here that is not here, present, but could be made to appear to be present with us. So there's a lot of really cool things there.


text:
Thursday, October 22, 2020
Blacice Entertainment, one of the
UK's most fastest developing urban music projects. was Founded
in1997 by Anthony James BSc, Blacice Entertainment has really
taken the digital music age by storm, extrapolating the very
best out of Technology and the creativity of today's strong
minded youth.
The group aims to push a message of
positive collaboration to all UK artist: looking to be
heard in the un-politically correct music industry. Providing
opportunities for those whom just want to be heard, and know
they make the grade...
Its a positive message backed by real
people from the real streets and the real ghetto. Opportunities
are hard to come by, but we believe they should not be if
you are tough enough and good enough...


text:
mardi, 27 octobre 2020
Author : Salamon, George C., o.m.i. and Davidson, J.N.
Description : 37p., ill.
Note : Contains the history of the Catholic church in the Rat Portage area as well as the history of the Parish of Notre Dame du Portage (Rat Portage, Kenora).
The item's cost seen below includes shipping and handling to addresses in Canada only.
For addresses outside of Canada, an additional shipping fee will be added separately. Please contact us at firstname.lastname@example.com if you would like to receive a quote before submitting your order.
|Centre du patrimoine, 340, boulevard Provencher, Saint-Boniface, (Manitoba) R2H 0G7 - T 204-233-4888 -
|©2010 - Société historique de Saint-Boniface
|Voici la photo du Centre du patrimoine sur Google Maps


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Golf: Loudoun County Advances to Second Straight State Tournament
You know that old playoff adage: survive and advance? Well that approach rang true once again for Loudoun County at the Virginia AA Region II golf tournament on Wednesday in Front Royal.
On a blustery day at the Shenandoah Valley Golf Club, the Raiders were able to survive less than ideal conditions and a rare high score from their top player to finish second and advance to next week's state tournament.
Loudoun County - which surprised everyone when they upended host Western Albemarle last fall to take the region crown - fought through the wind to post a 320. Senior Jon Youst and junior Andrew Brenneman both shot 79 and Kevin Cook and Michael Linville carded 81s to cover for Dulles District champion Brantley Kushner's season-high 88.
"Conditions were tough," Loudoun County Coach John Laycock said. "There's probably nothing harder to play in than wind. It requires a lot of mental toughness to play in those kinds of conditions. We didn't do as well as we have, but that's understandable. It's called survive and advance, and that's really what we did."
Western Albemarle reclaimed the tournament title with a 310 team total and the Warriors own Patrick Leisure won the individual tournament with a 1-over 72.
Next up for the Raiders is a trip to Williamsburg National for their second consecutive state tournament appearance. No one on the team has played the course, other than Laycock, who says it features fairways that wind through trees and plenty of sand.
"It's a very typical tidewater golf course, but it's fair" he said. "I don't think it's as tricked up as some golf courses are, so they should be able to manage it pretty well."
Loudoun County - which finished seventh at last year's state tournament - will play a practice round Sunday before taking the course for the two-day 36-hole tournament starting Monday morning. Laycock expects last year's experience to help the team contend with some of the best high school golfers in Virginia.
"I think last year will help us immensely," Laycock said. "Going down there last year, we were predominantly sophomores. I just looked at some of the other teams that were so much more physically mature than we were. But my kids have grown up. They've gotten a little bigger, a little stronger, a little smarter and they saw what it was like last year. They know that there are some players down there.
"It's exciting to be able to compete at that level and hopefully succeed. We're just anxious to get down there and see where we stand."
Matt Brooks
October 8, 2009; 12:15 PM ET
Categories: AA Dulles , Golf , Loudoun County High School , Region II
Save & Share: Previous: Westfield Holds Off Rival Centreville, 1-0
Next: Lister, Loudoun Valley Win Regional Golf Titles
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text:
Regulations are getting wound up tighter and tighter – here in Australia and worldwide. What used to be the 'Wild West' of the Internet is fast becoming a game of 'Keeping to the straight and narrow'.
In 2013 Privacy and data collection were targets and front page news. Going forward, in 2014, look for Copyright and Copyright Infringement to become a central point of discussion.
So with the New Year, what better time to review your website for Copyright breaches and, if necessary, clean up your act. So what is Copyright? And what is Copyright Infringement?
What is Copyright?
Generally speaking, Copyright protection is an exclusive right that exists to protect the creator of an original 'work'. This work must be in a fixed, tangible form – in other words, it cannot be just an idea. The Copyright owner can license their work, sell or assign their rights and can prevent others from using it, reproducing or communicating the work.
Copyright protection is automatic for the owner, immediate and does not require registration in Australia nor do you have to put any type of Copyright notification on the work. But if you have a trademark or patent that is registrable, it is easier to show your ownership and give notice of your protection to others.
How is Copyright infringed?
Here at Legal123, we've already published a handy infographic on Copyright Infringement. It describes the 5 most common myths about Copyright and helps explain how Copyright can be infringed – even accidentally sometimes. Here is a summary:
- Myth: If a work is posted on the Internet it loses Copyright protection. This is perhaps the biggest misconception – you never lose Copyright protection as an owner of a work.
- Myth: You can copy or share something online if you give the owner credit or link back to them. False again! You cannot use other people's work without getting their permission. The only other way you can legally use or repost their material is if you fall within one of the 'fair dealing exceptions'.
- Myth: If you alter, manipulate or 'tweak' an image or work, there is no breach of Copyright. No way! You have used someone else's work and as soon as you do this, no matter what you did with it, you breached their Copyright.
- Myth: If a work has no Copyright symbol there is no Copyright protection. False, there is no requirement to add a Copyright symbol for a work to be protected. It's protected from the moment it is produced and this protection is never lost.
- Myth: I can share and post someone's work as long as I don't profit from it. This is so wrong! You are still breaching Copyright.
So have you breached someone's Copyright? For example: you shared an Internet meme, copied an image for your business page, shared a good article you read with your customers or you saw a great photo and wanted to share it. Remember, there are only a few, very specific 'fair dealing exceptions'. They include using someone else's work for: research, education, criticism, review, parody or satire.
What should I do if someone steals my work?
Lastly, you might have had your Copyright infringed. What should you do? Send them a Copyright Infringement Notice, asking them to either take down the work or give you a link or attribution. Alternatively, you can offer them a licence to use the work for a fee. And if they have profited from your work (i.e. they're selling your photos, designs, etc.) you can claim royalties from them!
So there you go. The moral of the story is think twice before you 'share' your favorite photo or 'borrow' an article for your business blog – you may be stealing someone's Copyrighted work. And make it your New Year's resolution to stop this, clean up your website and make sure you respect other people's Copyright.
If someone has copied your work online, use our Copyright Infringement Notice to request take down, compensation or offer licensing. Plus what to do if you're ignored. Get the Legal123:


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I just recently bought one of those foam pads used for exercising. I may take a pair of scissors to it and make one Good idea to use that kind of material, much more sturdy than reflextic stuff.parkinson1963 wrote:A wonderful cozy material is one made out of those blue foam pads that everyone has bought. Using scissors and glue make one.
The best part is because it rigid it can be used separately from the pot, i.e place freer bag meal in cozy add hot water, wait, eat. This frees up the pot to make amazing hot chocolate with whole milk powder. This gives the benefits of have a nice bowl to eat out of and being able to use the pot for drinking out of.
A cheap, light-weight cozy
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Re: A cheap, light-weight cozy
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text: Had an extremely exciting Sunday celebrating a couple birthdays. Our first birthday party was for our friend Avery who turned 2 with a Pooh themed bash. The afternoon was spent celebrating my Gramps 99th birthday! While celebrating at my grandparents my cousin brought over 4 new chicks that she picked up which made for a little extra excitement.


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Adopt an Olive Tree. Nudo Adopt first started over 10 years ago - providing premium Italian extra virgin olive oil from your own adopted tree.
Its concept was (and still is to this day) a collaboration of small scale, artisanal producers keeping traditional farming practices alive and protecting the countryside from intensive and destructive modern farming methods.
Nudo was founded by Jason Gibb and Cathy Rogers in 2005 after buying and restoring an abandoned 21 acre olive grove in Le Marche, Italy. In 2014 Katharine Doré and her son Toby joined the adoption scheme with their beautiful Ligurian grove and have since become the current owners of Nudo Adopt.
The programme is a platform for micro-producers to bring high-quality, speciality food to a wider audience: each producer keeps responsibility for the care of their grove, garden or field and Nudo helps give security to the farmers by making the link with the customer.
Please see notonthehighstreet.com's delivery policy.
Please see notonthehighstreet.com's returns policy.
100 Borough high Street, London, Greater London, SE1 1LB, GB
Please see notonthehighstreet.com's terms & conditions.


text:
Zelt am Hauptplatz - Bad Radkersburg concerts
We're sorry, we currently do not have any tickets on-sale for concerts in Zelt am Hauptplatz - Bad Radkersburg.
We're always adding events, so please check back soon!
Otherwise, try searching for the artist or venue you are interested in, using the search form above, or
ask us to add it. Thanks!


text:
More About CUINPARADISE
Visit My SparkPage Send Me SparkMail
Recipes I've Shared:
CUINPARADISE currently has no shared recipes.
Recipes I've Rated:
- Homemade Turkey Soup
- Kitchen Basics: Chicken Noodle Soup
- Pork Chop & Apple Bake
- Baked "Fried" Chicken
- Mushroom and zucchini omelette
- Cashew Beef and Broccoli Stir-Fry
- Tropical Grilled Chicken
- Main Event Marinara Sauce
- Strawberry Banana Smoothie
- Blueberry Orange Smoothie
- Teriyaki Asian Fish Veggie Packets.
- Bestest Grilled Turkey Burger by Rebbie
- Simple Banana/Orange Smoothie
- Orange "Chicken" Glaze
- Grilled Garlic Citrus Flank Steak
- Corn Bread muffins
- World's Best Spinach and Artichoke Dip
- Super Simple Lemon Pepper Salmon Steak
- crispy potatoe wedges
- Baked White Fish with Mushrooms
- BBQ Chicken Wings
- Light Mustard Honey Chicken - Baked
- Easy Baked Chicken Breast
- Eggplant Napoleon
- Abs Diet Trail Mix
- Buttered Parmesean Egg Noodles
- Easy Slow Cooker Lemony Garlic Chicken Breast
- Mushroom Broccoli Fritatta
- turkey burger italian
- Pork Chop and Apple Bake
- 15-Minute Rosemary Lamb Chops
- Turkey Chili with Corn and Black Beans
- Slow Cooker Creamy Italian Chicken
- Poached Tilapia
- Fish Veronique