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Ben Ebert is a hematologist and oncologist whose research focuses on cancers and other disorders that affect the production of red blood cells. He also leads the leukemia program at the Dana-Farber/Harvard Cancer Center.
Meet Our Researchers
Since September 2014, BroadIgnite has supported a wide array of innovative projects to drive biology forward and revolutionize our understanding of disease. Learn more about our awardees and their funded projects below.
- Institute Member at the Broad Institute
- Associate Professor of Medicine at Harvard Medical School
- Co-director of the Cancer Program at the Harvard Stem Cell Institute
Laboratory models of leukemia often don't reflect the genetic reality of patients' cancers. Ben is tackling this challenge by using the CRISPR genome-editing tool to develop new models of drug-resistant childhood leukemias with more realistic mutations—including some identified in his lab. These models can be used to search for new treatments that can kill the drug-resistant cancer cells. This project will provide researchers with a steady and reliable source of leukemia models to advance our understanding of blood cancers and test new experimental therapies.
Ebert and his team have created several models and used them to test how different mutations change how the blood cancers respond to a specific cancer drug.
- Institute Member and Co-Director of the Program in Medical and Population Genetics at the Broad Institute
- Group Leader in the Analytic and Translational Genetics Unit at Massachusetts General Hospital
Daniel MacArthur is a geneticist who pulls useful information out of genetic "big data." He is also an assistant professor at Harvard Medical School.
As a BroadIgnite awardee, Daniel is using his funds to launch an initiative to provide definitive diagnoses for 20 patients suffering from rare muscle diseases using a method developed at the Broad. By sequencing the patients' expressed genes, he's working to identify the exact genetic cause of these severe diseases.
Using the latest Broad technology, the MacArthur lab has analyzed the expressed genes from 37 patients with severe muscle disease. As a result, the lab has successfully diagnosed 15 patients with rare disorders, and continues to crunch the data for the remaining participants. For three of these patients' families, clinical collaborators have designed prenatal tests to enable them to have healthy additional children.
Listen to the BroadIgnite Podcast with Daniel MacArthur and Monkol Lek
Watch a video about Daniel's research
- Institute Member at the Broad Institute
- Assistant Professor of Pediatrics at Harvard Medical School
Nick Haining is a pediatric oncologist who studies cancer immunology—harnessing a patient's immune system to attack tumors. Nick also sees patients at the Dana-Farber Cancer Institute.
Recent developments in cancer immunotherapy hold great promise, but so far only a tiny fraction of patients respond to the current drugs. Nick hopes to lay the groundwork for identifying new therapeutic targets by understanding the underlying biology of the interactions between cancer and the immune system. He's using his BroadIgnite funds to systematically and comprehensively identify the genetic mutations and pathways that enable tumors to elude our immune defense.
Nick's laboratory has built the tools necessary to tackle this project—mouse cancer cell lines for melanoma, lung cancer, and colon cancer, using the CRISPR genome-editing tool. His team is now working closely with the Broad's Genetic Perturbation Platform to scan the genome to identify the genes involved in cancer therapy resistance, and probe some of these promising genes to identify new therapies.
- Chief Data Officer at the Broad Institute
- Venture Partner at Google Ventures
Anthony Philippakis is a physician, geneticist, and data scientist. He is also a cardiologist at Brigham and Women's Hospital, where he cares for patients with rare genetic cardiovascular diseases.
BroadIgnite funding is supporting Anthony's efforts to launch a "Genomic Matchmaker" database. This revolutionary database will allow clinicians and researchers to rapidly scan vast catalogs of genomic data to find other samples with the same genetic changes—advancing biomedical research and guiding clinical decisions.
BroadIgnite support has seeded further funding of the "genomic matchmaker" devised by Anthony and his colleagues. Thanks to BroadIgnite funds, he has recruited a key staff member to identify suitable patient cohorts and manage the portal's large datasets, and his team is now refining and extending existing software.
- Associate Member at the Broad Institute
- Assistant Professor at Harvard Medical School
Eliezer Van Allen is a cancer researcher who uses genomics to guide treatment decisions in genitourinary (prostate, kidney, testicular, and bladder) cancers. He is also a practicing oncologist at Dana-Farber/Partners Cancer Care.
Eli is using BroadIgnite funding to study exceptional responders—cancer patients who respond extremely well to new immunotherapies.
Eli and his team have sequenced the expressed genes of five exceptional responders and three of the resistant tumors from these patients. That allowed them to identify a new gene candidate that mediates the response to a novel cancer immunotherapeutic. Eli is now analyzing the data to identify other genes that could play such a role, especially in rare cancers like sarcoma.
Listen to the BroadIgnite Podcast with Eli van Allen
Watch Eli van Allen discuss how genomics is transforming cancer care
- Graduate students at the Broad Institute of MIT and Harvard
Eric Minikel and Sonia Vallabh are Ph.D. students in Stuart Schreiber's laboratory at the Broad Institute. In 2010, Sonia's mother abruptly developed and died of prion disease— a rapidly progressive and fatal neurodegenerative disorder caused by the spread of misfolded proteins in the brain. The following year, Sonia learned she had the same mutation that caused her mother's disease. Thus, Sonia and her husband Eric left their career in consulting to begin studying biology, with the long-term goal of designing small molecule therapeutics for prion diseases.
Eric and Sonia are developing methods and models to study prions, find and test new therapeutics, and identify ways to track the progress of the disease.
With their BroadIgnite funds, they have set up a dedicated room at the Broad with all the tools necessary to establish RT-QuIC, a new assay, as a tool for drug discovery. They are now isolating pure prion protein from cells to use in their experiments.
- Associate Member at the Broad Institute
- Assistant Professor at MIT
- Assistant in Immunology at Massachusetts General Hospital (MGH)
Alex Shalek is a chemical biologist who uses nanotechnology techniques to understand how cells work together in health and disease. He is the Hermann L.F. von Helmholtz Career Development Professor at the Harvard-MIT Program in Health Sciences and Technology (HST) and an assistant professor of chemistry at MIT, where he is a core member of the Institute for Medical Engineering and Science. He is also an associate member of the Ragon Institute of MGH, MIT and Harvard.
BroadIgnite funding is supporting the Shalek lab's efforts to use cutting-edge single-cell genomic assays to study HIV. They're studying how a rare population of HIV+ individuals, known as elite controllers, prevents the spread and growth of the virus in their bodies without treatment. The award has enabled the lab to travel to Durban, South Africa to follow up on initial findings with collaborators at the Kwazulu-Natal Research Institute for Tuberculosis and HIV.
- Postdoctoral Fellow at the Broad Institute of MIT and Harvard
Sara Jones is a postdoctoral fellow in Feng Zhang's lab at the Broad Institute. Her research focuses on identifying and developing novel strategies for gene editing through the study of organisms that aren't usually studied in the lab.
BroadIgnite funding is supporting Sara's efforts to adapt the clever genetic strategies of "pond scum" for therapeutic use. She studies a pond-dwelling microorganism that shatters its DNA into hundreds of thousands of pieces, which it must rearrange and reassemble to survive. By understanding how such complex genome architectures can be sustained in nature, she hopes to build a new platform for gene therapy in mammalian cells.
- Postdoctoral Fellow at Broad Institute of MIT and Harvard
Roby Bhattacharyya is an attending physician in infectious diseases at Massachusetts General Hospital and a postdoctoral researcher in Deb Hung's lab studying antibiotic resistance. He seeks to understand how bacteria adapt to the most powerful antibiotics and design rapid methods for detecting resistance.
BroadIgnite funds will allow Roby to develop and test a rapid diagnostic for meningitis that can identify the responsible pathogen from the cerebrospinal fluid of patients. Bacteria, viruses, or fungi can all cause meningitis, but it can take up to a week to identify the source of the infection. In the meantime, doctors have to make an educated guess—and may end up prescribing antibiotics that don't actually target the disease, but can instead contribute to antibiotic resistance. Roby seeks to shorten the time to diagnosis by developing an RNA-based assay that would identify the source pathogen by its expressed genes. Unlike current tests, it would work for any variety of meningitis.
- Postdoctoral researcher in the labs of Eric Lander and Ramnik Xavier at the Broad Institute of MIT and Harvard
Moran Yassour is investigating how different methods of childbirth affect children's gut microbiomes.
The bacteria in a baby's gut can differ radically, depending on how the baby was delivered. But what bacteria are impacted, and why? BroadIgnite is funding Moran's research into this very question, through a study at Massachusetts General Hospital.
Listen to the BroadIgnite podcast with Moran Yassour
- Associate Member at the Broad Institute
- Assistant Professor at Harvard Medical School
- Deputy Director, Center for Cancer Precision Medicine, Dana-Farber Cancer Institute
Nikhil Wagle is a medical oncologist who studies cancer genomics and precision cancer medicine. He characterizes the genomes of patient tumor samples to better understand the molecular roots of cancer and drug resistance and to identify mutations that can be targeted with available treatments.
BroadIgnite support has propelled Wagle's Metastatic Breast Cancer (MBC) Project, an initiative to recruit people across the country with metastatic breast cancer to participate in research. The funding has allowed him to analyze some of these samples, with the aim of understanding the differences in tumors that arise in younger versus older patients.
Read about Nikhil's research in the Wall Street Journal
- Postdoctoral Fellow at Broad Institute of MIT and Harvard
- Attending Pathologist at Massachusetts General Hospital
Siddhartha Jaiswal is an attending pathologist at Massachusetts General Hospital and a postdoctoral fellow in Ben Ebert's lab at the Broad Institute studying age-related diseases. His research is focused on the relationship between genetic mutations, cell biology, and aging.
BroadIgnite funding will allow Sidd to analyze the DNA of people with Alzheimer's to look for age-related genetic mutations that might play a role in the disease. In previous research, Sidd has shown that when age-related mutations occur in blood cells, they can lead to blood cancer. Strikingly, he found that the same set of mutations is also implicated in cardiovascular diseases such as heart attack and stroke. That suggests that these mutations could change how some blood cells function—and also that a shared mechanism underlies diseases of aging like cancer, cardiovascular disease, and dementia. Based on these insights, his BroadIgnite-funded project will determine whether these mutations are also at play in Alzheimer's; if confirmed, this could eventually lead to powerful new therapeutic avenues in diseases of aging.
- Institute Member at the Broad Institute
- Assistant Professor at Harvard Medical School
- Associate Physician at Brigham and Women's Hospital
Anna Greka, an institute member of the Broad Institute of MIT and Harvard, is a practicing nephrologist and scientist who studies the basic molecular mechanisms of kidney disease in order to eventually develop targeted therapies. She is also an assistant professor at Harvard Medical School and an associate physician in the Renal Division at Brigham and Women's Hospital.
Genetic kidney diseases are rare but devastating, with extremely limited treatment options. Because there are so few patients, each one can provide clues that can help improve therapy for all sufferers. Anna has identified a kidney disease patient who responds exceptionally well to a particular drug, and with BroadIgnite support, she'll identify similar patients in order to understand why the drug is effective for them. Those results could improve the lives of many patients—from those with rare, genetic kidney diseases to the millions who have diabetic kidney disease.
- Computational Scientist at the Broad Institute and Massachusetts General Hospital
Alex Bloemendal is a computational scientist at the Broad Institute of MIT and Harvard and at the Analytic and Translational Genetics Unit of Massachusetts General Hospital. As a member of Broad institute member Ben Neale's team, Bloemendal builds computational infrastructure to enable biologists to harness "big data" and analyze the genetics of disease.
With BroadIgnite funding, Alex plans to build a new open-source computational tool to expedite diagnosis of a wide variety of diseases.
- Postdoctoral fellow in Sekar Kathiresan's lab at the Broad Institute of MIT and Harvard
- Cardiologist at Massachusetts General Hospital
- Instructor in Medicine at Harvard Medical School
Amit Khera hopes to prevent heart attacks by understanding the genetic mutations behind cardiovascular disease.
What genetic mutations drive the risk of cardiovascular disease? Amit wants to find out. His research focuses on the clinical interpretations of genetic risk, the smartest ways to communicate genetic risk to patients, and how doctors and patients can modify genetic risk through medicine or lifestyle changes.
- Group Leader in the Cancer Program at the Broad Institute of MIT and Harvard
Viktor Adalsteinsson runs the Cancer Program's blood biopsy team—a group of scientists, engineers, oncologists, and computational biologists that develops technologies to monitor the progression of cancer and other diseases through a simple blood draw.
BroadIgnite support will accelerate the team's pioneering efforts to scan the free-floating DNA in blood for signs of cancer and other diseases. The funding will also support the development of high-powered cellular analysis technology, which can yield insights on the cell types commonly damaged during these diseases.
- Director of the Vertebrate Genomics Group at the Broad Institute of MIT and Harvard
Elinor Karlsson is the director of the Broad's vertebrate genomics group. She studies dog genetics as a window into the pathways involved in psychiatric and neurodegenerative diseases shared by people and pooches, including autism spectrum disorders (ASD).
With BroadIgnite funding, Elinor's team will launch an investigation into ASD by collecting behavioral and genetic data on 100 dog-wolf hybrids. Why the hybrids? Compared to dogs, wolves make less eye contact, don't bond easily with other species, and are sensitive to novelty—behaviors that people with autism often display. Elinor believes that understanding the genes that are different between dogs and wolves will provide important clues about ASD in humans.
Listen to the BroadIgnite Podcast with Elinor Karlsson
- Associate Director of the Genomic Center for Infectious Diseases at the Broad Institute of MIT and Harvard
Daniel Neafsey is the associate director of the Broad's Genomic Center for Infectious Diseases. Dan is an expert in mosquitoes and their role in transmitting some of the world's deadliest diseases, such as malaria and dengue. By unraveling mosquito biology, Dan hopes to learn which drugs, insecticides, and vaccines are likely to work—and why.
BroadIgnite funds will help Dan tackle another mosquito-borne threat: Zika. He's developing a new way to track mosquitoes in the wild by introducing short, synthetic genetic markers—DNA 'barcodes'—into larval and adult mosquitoes. By releasing and then recapturing these barcoded bugs, Dan will learn a wealth of information, including mosquito lifespan, population size, and which pest-control measures actually work.
- Leader of the bacterial genomics group in the Infectious Disease and Microbiome Program at the Broad Institute of MIT and Harvard
Ashlee Earl wants to understand how lethal, drug-resistant bacteria flourish and spread, with the goal of finding novel intervention strategies.
BroadIgnite support will jumpstart her efforts to thwart the deadly drug-resistant bacteria called carbapenem-resistant Enterobacteriaceae (CRE). Her studies have shown that CRE are more diverse than previously thought—and that this diversity helps them spread rapidly in hospital settings. Ashlee's team aims to learn more about the genetic diversity of CRE, with the goal of finding therapies that can target the genes and pathways fueling drug resistance.
- Principal Investigator in the Stanley Center for Psychiatric Research at the Broad Institute of MIT and Harvard
- Assistant Professor of Psychiatry at Harvard Medical School
Evan Macosko is a physician-scientist who wants to decode mental illness by using novel, high-throughput techniques to analyze brain cells.
An astonishingly diverse and complex collection of cell types populates the human brain—making it difficult to study, especially when you're trying to learn how cells malfunction in complicated disorders like schizophrenia and autism. Evan and his team will develop new technologies to identify these cells and understand how they contribute to disease.
- Postdoctoral Fellow at the Broad Institute of MIT and Harvard
- Pediatric Neuro-oncologist at Dana-Farber Cancer Institute
- Instructor in Pediatrics at Harvard Medical School
Mariella Filbin wants to identify genetic dependencies—mutations that the tumors need to survive—in pediatric brain cancers, with the aim of finding potential therapies.
Most children with diffuse intrinsic pontine glioma (DIPG), a pediatric brain tumor that grows rapidly and has no treatment, die within 12 months of their initial diagnosis. With BroadIgnite funding, Mariella will expand the exciting findings she's recently made about DIPG, describing cancer stem cells and more mature cancer cells in DIPG for the first time, and potentially uncovering therapeutic leads.
- Associate Member at the Broad Institute of MIT and Harvard
- Assistant Professor in Radiology at Harvard Medical School
- Laboratory Director at the Department of Radiology at Brigham and Women's Hospital
- Faculty at the Joint Center for Cancer Precision Medicine at Dana-Farber Cancer Institute
Oliver Jonas develops microdevices that diagnose, probe, and treat live tissues within their native environment.
Typically the microdevice—which is smaller than a rice grain—is implanted via biopsy needle into a tumor, where it provides small doses of 30 different chemotherapies and measures the patient's response to each. The device remains implanted for 24 hours. Then it's retrieved with the surrounding tissue, which researchers analyze to learn if the therapies were effective. BroadIgnite will support Oliver's exploration of whether this technique can also work in the human brain, gauging the effectiveness of drugs for neurodegenerative and neuropsychiatric diseases.
- Postdoctoral Associate at Broad Institute of MIT and Harvard
- Postdoctoral Research Fellow at Brigham and Women's Hospital and Harvard Medical School
Samantha Riesenfeld is interested in using advanced statistical methods from data science to understand food allergy.
Food allergies endanger more than 220 million people worldwide, two-thirds of whom are children. Yet we still barely understand the biology behind these potentially life-threatening reactions to food. We do know that it is related to the interplay between the immune system and epithelial tissue. BroadIgnite funding will help Sam use statistical machine learning approaches to test an unconventional but potentially revolutionary hypothesis: that our nervous system mediates the immune system's response.
- Postdoctoral Associate at Broad Institute of MIT and Harvard
Andrés Colubri is a computational researcher, visual artist, and designer. He develops new tools that integrate statistics and user-friendly visuals and interfaces to help improve our ability to fight emerging outbreaks.
Lassa fever infects 300,000 people a year in West Africa, causing as many as 5,000 deaths. Andrés is developing new tools that help doctors securely share patient data in real time to better track—and ultimately stop—outbreaks of this deadly disease.
- Graduate Student, Medical and Population Genetics Program, Broad Institute of MIT and Harvard
- Graduate Student, Biomedical and Biological Sciences Program, Harvard Medical School
Beryl Cummings is a graduate student specializing in cutting-edge genomic technologies.
Rare diseases cause enormous suffering, especially among the youngest patients, and diagnoses can take years. This means that patients and families often have to suffer through long periods of pain and uncertainty. Beryl will use a technology called RNA-sequencing, which analyzes genes expressed across tissues, to determine if it can help physicians provide rapid, accurate diagnoses to patients and their families.
- Associate Member, Broad Institute of MIT and Harvard
- Cardiologist, Department of Medicine, Massachusetts General Hospital
- Assistant Professor of Medicine, Harvard Medical School
Steven Lubitz is a cardiologist at Massachusetts General Hospital who specializes in arrhythmias.
Atrial fibrillation (AFib), an irregular and often rapid heart rate, affects more than 5 million people in the U.S.; if left untreated, it can triple the risk of stroke. Steven will develop a machine-learning approach to track and analyze genomic data for AFib—both known variants associated with AFib and new variants identified through our research. Our aim is to improve our ability to detect this form of heart arrhythmia.
- Associate Member, Broad Institute of MIT and Harvard
- Physician Scientist and Instructor in Medicine, Dana-Farber Cancer Institute
Zuzana Tothova is a medical oncologist at the Dana-Farber Cancer Institute. Her research focuses on blood cancers, a group of cancers including acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
MDS affects 30,000 new people each year in the U.S., and its long-term survival rate is less than 5 percent. About 11 percent of MDS patients have mutations in a protein complex called the cohesion complex, which plays an essential role in regulating cell division. Zuzana plans to investigate how cohesin mutations affect a process called DNA looping. Her hypothesis is that malfunctions in DNA looping lead to the development of MDS and other blood diseases.
- Institute Scientist, Broad Institute of MIT and Harvard
- Senior Director, Imaging Platform, Broad Institute of MIT and Harvard
Anne Carpenter is a pioneer in building scalable, user-friendly technologies for extracting data from images. She directs a lab of biologists and computer scientists who develop and use advanced machine learning methods to identify important patterns in cell populations. Anne's team is best known for developing CellProfiler, the first open-source software for cell–image analysis.
New therapies are urgently needed for patients with psychiatric disorders, but developing these drugs is an especially lengthy process. Anne's lab wants to accelerate the timeline by finding new, efficient methods to test potential therapies in the early stages of their development.
- Postdoctoral Fellow, Macosko Lab, Broad Institute of MIT and Harvard
Aleks Goeva is a statistician specializing in machine-learning models for understanding the human brain.
The human brain is one of the most complex structures in the living world. For centuries, scientists have struggled to understand it. Only in the past few years have state of the art tools like single-cell technologies and 3D cellular models offered hope of gaining insight into the workings of the brain—not to mention mystifying disorders such as schizophrenia, autism, and Alzheimer's. But they're also generating unprecedented amounts of data that labs are currently ill-equipped to handle. For her project, Aleks is experimenting with a novel data-analysis method to tackle this growing mountain of data.
- Research Fellow, Broad Institute of MIT and Harvard
- Instructor in Medicine, Harvard Medical School
- Associate Physician, Cardiovascular Medicine, Brigham and Women's Hospital
Rajat Gupta is a cardiologist and vascular biology researcher who uses stem cell–derived and genome-edited vascular cells to understand coronary artery disease.
Every year, hundreds of thousands of people in the U.S. die of sudden cardiac death. And, as vital as this area of study is, we still don't know a lot about a crucial factor: heart cells. Working with clinical partners, Rajat will investigate heart cells in coronary blockages for data that can abet our ability to predict who is most at risk for sudden cardiac death.
- Postdoctoral associate at the Broad Institute of MIT and Harvard
Katie Geiger-Schuller's research focuses on the immune system's ability to sense and fight disease.
Katie will use her BroadIgnite award to investigate how immune cells thwart invaders like carcinogens and allergens. Using a new technology that provides rapid readouts of cellular response to multiple stimuli, she will douse batches of immune cells with asbestos and other triggers—and evaluate the results. If successful, the experiment will shed light on potential treatments and provide a more efficient way to test them.
- Postdoctoral researcher at the Broad Institute of MIT and Harvard
Susan Klaeger wants to develop the next wave of personalized cancer therapies.
Personalized cancer vaccines—which train a patient's immune system to identify and destroy tumors while sparing healthy tissue—may be a game changer in immunotherapy. Susan will use her BroadIgnite award to hone a new technology that can improve the specificity with which researchers customize these vaccines.
- Visiting postdoctoral scholar at the Broad Institute of MIT and Harvard
Nicolas Wieder is a physician-scientist investigating the molecular mysteries behind metabolic disease.
Metabolic syndrome—a cluster of risk factors that increases one's susceptibility to heart disease, diabetes, neurodegenerative diseases, and obesity—has reached epidemic levels across the globe. But there's still a lot we don't know a lot about the molecular mechanisms behind this disorder—making it difficult to develop therapies. Nicolas hopes to lay the groundwork for new therapies by investigating one of the most poorly understood causes of metabolic diseases: how excessive exposure to certain fats can damage cells and tissue.
- Associate Member at the Broad Institute of MIT and Harvard
- Melvyn J. and Geraldine L. Glimcher Assistant Professor of Immunology and Infectious Diseases at the Harvard T.H. Chan School of Public Health Physician in the Division of Infectious Disease
Yonatan Grad is a physician-scientist studying infectious diseases and how pathogens evolve and spread throughout populations.
Yonatan will collect and study strains of Neisseria gonorrhoeae, the bacteria that causes gonorrhea, from the Himba, a nomadic, pastoralist tribe of 50,000 people in northern Namibia. The Himba have very high rates of infection—more than 60 percent of adults carry the bacteria—but very low rates of symptomatic disease. Yonatan is using his BroadIgnite award to support travel to Namibia, collect specimens, and conduct DNA sequencing. This work will lead to important insights that will impact the understanding and treatment of antibiotic-resistant gonorrhea—a rising global public health threat—as well as other infectious diseases.
- Senior Group Leader in the Kidney Disease Initiative at the Broad Institute of MIT and Harvard
Jamie Marshall leads a collaboration aimed at unraveling the molecular mechanisms of kidney disease to develop targeted therapies.
Chronic kidney diseases afflict 500 million people worldwide, yet many patients face limited treatment options. Understanding the genes, proteins, and pathways involved in the organ's deterioration can give patients early—and potentially lifesaving—diagnoses and therapies. Jamie will use her BroadIgnite funding to create cellular maps of the kidney that give researchers a fuller picture of different cell types and interactions—and what happens when they malfunction.
- Postdoctoral fellow at the Broad Institute of MIT and Harvard and Massachusetts General Hospital (MGH)
Karin Pelka studies cancer immunology—which focuses on how to harness a patient's own immune system to attack tumors.
Colorectal cancer is the second-leading cause of cancer death in the U.S. While recent developments in checkpoint inhibitors—an important class of cancer immunotherapies—hold great promise, most patients do not respond to these powerful drugs, for reasons that remain unclear. Karin wants to find out why by using her BroadIgnite funding to analyze colorectal tumors from patients at MGH.


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Olive Hill Executes $21.4M in Leasing Activity02/25/2019
Los Angeles-based Olive Hill Group, LLC completed 97,000 square feet in leasing activity valued at roughly $21.4 million at its newly-renovated Class A creative office campus, The Courtyard at 200-300 Corporate Pointe in Culver City. The deals involved Paychex, Ipsos and Pearson, and follow the recent completion of a major redevelopment and rebranding of the property.
Olive Hill Group's Tim Lee says, "The recent addition of a national Fortune 100 computer technology company as an anchor tenant at our Culver City creative campus continues to solidify Silicon Beach's position as one of the fastest-growing, most dynamic tech markets in Southern California.
Situated on the east side of the 405 Freeway near Jefferson Boulevard, 200-300 Corporate Pointe features a campus atmosphere, flexible outdoor work space, a soothing waterfall, and a lagoon. Olive Hill has increased occupancy at the award-winning property from 72% to 95% just two and a half years after acquiring the asset.
Article released in Connect California, Commercial Real Estate News
URL to article:

subset: commoncrawl


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HÀ NỘI – The Ministry of Industry and Trade has submitted a proposal to Prime Minister Nguyễn Xuân Phúc suggesting solutions to issues raised by the Việt Nam Textile and Apparel Association (VITAS). This includes a proposition to abolish inspections of formaldehyde content in textiles and garments.
VITAS said the current regulation on this inspection has no legal grounds, and is costly and time-consuming. The ministry has recommended that the directive be abolished and instead, a national technical standard for garments and textile products be put in place. The standard is to be promulgated by the beginning of 2017.
Responding to VITAS' demand for modifications in the garment and textile industry's planning and strategy, the ministry has scheduled changes next year in keeping with market realities.
The ministry said the sector's ability in dyeing has been limited due to shortage of capital for investment in modern technologies and waste water management.
To encourage growth, it has proposed that the Government conduct specific studies to grant licences for the establishment of 500- to 1,000-hectare garment and textile industrial parks (IPs), as well as give them preferential interest rates.
Deputy minister Trần Quốc Khánh recently told Việt Nam News that the ministry has tried to solve the sector's business problems and that legal documents under the ministry's authority that are causing problems would be abolished in the shortest possible time. -- VNS


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SeaPro Signal Buoy DSMB 'Delayed Surface Marker Buoy' 60x7", Kota Kinabalu, Malaysia
The SeaPro Signal Buoy, also known as a 'Safety Sausage' or 'Delayed Surface Marker Buoy' is a must for any Scuba Diver or keen/adventurous snorkeller. It measures 60x7" wide (150x17.5cm) and is bright red/Yellow in colour. Has the word 'Diver Below' printed on both sides and is supplied with Oral Inflation Tube and Manual Dump Valve. So, next time you are out diving in Malaysia think about your safety and maybe you should have a DSMB - Safety Sausage
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Weaved cane is one of the oldest techniques used in furniture manufacturing. Cane strips have been used in objects since ancient times, originating as basket material and evolving into furniture. Caned furniture first appeared in Holland, England and France around the 1660's thanks to bustling trade with Asia. Thonet revolutionized the furniture industry in 1859 with its 214 chair. The simple caned seat contributed to the chair's extraordinary lightness, which meant that it was less expensive to produce and transport. In todays' contemporary interiors Cane Webbing is making a comeback. NLXL is the first wallpaper manufacturer to introduce Cane Webbing wallpaper. The collection comprises of a modernistic take on webbing by Studio Roderick Vos, as well as a classic approach by NLXL founders Mr. & Mrs. Vintage. The latter can be combined with 4 wainscoting designs. The wainscoting is mounted horizontally on top of the vertical strips of Cane Webbing wallpaper, just like it would be installed in real wood. Ultra high resolution scans make this new collection a typical NLXL trompe-l'oeil product where you will have to look twice to see its not the real thing.
- Size: 48,7x487cm (2,37m2) 19.2"x191.7" (25.5SqFt)
- This wallpaper requires horizontal intallation and can be combined with Mr. & Mrs Vintage webbing and wood panel wallpapers.
- 1 Roll of horizontal wainscoting covers 10 Drops of wallpaper (10 x 48,7 cm, see images)
- heavy duty 160grs wallpaper with paper top layer and non woven backing
- colourfast and washable with a soft cloth
- no wallpapering table necessary, glue is applied to wall
- Fire rating USA ASTM E 84.10 EU B.s1, do


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GPA Learn {School House Crew Review}
When the opportunity to review GPALOVEMATH by GPA LEARN through the Schoolhouse Crew Review Team came up I knew I had to apply for it. As a parent, I felt it was worth pursing. The helpful info-graphic and the fun character videos pretty much sealed my decisions. I felt my children would like it for many reasons and I was right in that assumption! Continue reading


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M2 Group (ASX:MTU) has reported a 25 per cent jump in net profit to $38.5 million and revenue increase of eight per cent to $546.2 million.
During the first half of 2015 financial year ending December 31, M2 added 61,000 new services including 26,000 broadband services and 14,000 new energy services.
It also rolled out 40 new Dodo Connect Kiosks, bringing the figure up to 60 kiosks across Queensland, NSW and Victoria shopping centres.
It also launched Dodo TV with Fetch and has connected about 1000 customers during its soft launch of Commander Electricity, which will now be rolled out across all channels. It offers business customers the opportunity to bundle their phone and electricity costs with 20 per cent discounts.
It also connected a further six NBN Points of Interconnect, totaling 44.
M2 launched its wholesale Cloud communications platform to partners in February, offering white label opportunities that are ready sell in 30 days.
M2 CEO, Geoff Horth, said the business was increasing its share in core markets and maximising shareholder returns on that growth through a relentless pursuit of operational efficiency.
The company is on track to meet its full 2015 financial year guidance of about 8 – 9 per cent revenue growth and 15 – 20 per cent net profit.
It plans to continue its focus on improving its business, enhance customer experience, invest in talent and leadership development as well as expand its NBN footprint.


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World Cup: England 12 South Africa 32
PUBLISHED: 11:15 02 November 2019 | UPDATED: 11:15 02 November 2019
PA Wire/PA Images
England were stunned by South Africa's relentless intensity as their World Cup quest ended with a crushing defeat in the final at International Stadium Yokohama.
A tense arm wrestle delivered its critical moment in the 66th minute when Makazole Mapimpi and Lukhanyo Am combined brilliantly down the left wing for the first of the Springboks' two tries.
England's defence was unlocked by the speed and accuracy of a move that saw Mapimpi cross to become the first Springbok to score a try in a World Cup final, although there was also a hint of a forward pass.
And with Eddie Jones' men forcing their attack in desperate pursuit of an unlikely comeback win, wing Cheslin Kolbe switched on the afterburners to deliver the knockout punch with six minutes remaining.
The victory maintains South Africa's 100 per cent record in finals and enables Siya Kolisi's team to join the famed Springboks of 1995 and 2007.
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After flying out of the blocks against New Zealand a week earlier, England were ambushed by South Africa's instant ferocity and never truly recovered.
Seeing prop Kyle Sinckler knocked out inside three minutes and unable to return was a savage setback - but it was only the beginning of their problems as panic swept through Red Rose ranks.
Nowhere was the vulnerability more evident than at the scrum where Tendai Mtawarira tormented Sinckler's replacement Dan Cole to win a series of penalties that placed South Africa in full command.
In recognition of the set-piece decimation, George Kruis was summoned into the second row to add ballast and while that made no difference, the arrival of Joe Marler brought a form of parity.
The damage had been done, however, and despite the valiant efforts of the Vunipola brothers, Tom Curry, Sam Underhill and Maro Itoje, England eventually fell apart as the heroics on display against the All Blacks became a distant memory.
South Africa had a laser-guided kicker in Handre Pollard to capitalise fully on the set-piece control, while Owen Farrell landed four penalties for the pre-match favourites, who have now lost in the final on three occasions.
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When everything old is new again3 min read . Updated: 02 Jun 2017, 06:41 AM IST
Companies are increasingly tapping nostalgia drive business, be it mobile phones (Nokia 3310), photography (Polaroid) or even beverages (Paper Boat)
Nostalgia makes for good business. In fashion, it's a given. Currently it is the comeback of flare pants, belle sleeve tops, power suits and ruffles. Think 1980's. Before that it was the 1960's, with the stylish Mad Men, and prior to that something else.
It works in tech as well. There is the Nokia 3310 that was relaunched in March this year. In markets like the UK, the 3310 was sold out on launch and buyers had to wait for one or two weeks for stocks to get replenished.
In April, music company Saregama India Ltd launched Saregama Caravan, a stereo system that looks like the radio from the 1970's and 1980's, with pre-loaded songs from that era to appeal to consumers above the age of 35. Then there are the vinyls, which remain popular. Even the humble cassette player and tapes are staging a comeback.
All this in the age of digital music and music streaming.
The retro resurrection has given the Polaroid camera a new lease of life. And even stationery like hardback paper diaries and year planners are seeing steady demand growth in the age of smartphones and tablets.
As for food, nostalgia has a proven track record. Think mom's cooking, samosa, kala khatta gola or Thums Up, which remains India's top-selling cola brand.
For the older consumer, nostalgia is indulgence. It's wearing rose-tinted glasses. It is going back in time and reliving a happy memory. For instance, if you grew up in the western or northern part of India, the smell of the samosa is likely to transport you back to memories of a childhood birthday party.
Newer consumer companies like Hector Beverages Pvt. Ltd's Paper Boat have managed to take consumers for a walk down memory lane with drinks like jamun kala khatta. In an age of impersonal digital media, it has created a feeling of connectedness through nostalgia.
Even restaurateurs have tapped this positive emotion.
Indian food, albeit with a modern twist, is a mega phenomenon among the millennials (those born between 1982 and 2000). Like our grandparents who did not like to experiment with their food, the young Indian has come a full circle to appreciate Indian cuisine. A host of restaurants like Bombay Canteen, Farzi Café and Toast and Tonic are testimony to this love affair.
But how do you explain nostalgia in the case of millennials? How can a 20-year-old be nostalgic about turntables which were not a part of her childhood home? Or how do you explain the growing popularity of Indian food among the young when there is a wider global cuisine and choices ranging from falafel to pasta, pizza and dim sums available?
For the younger consumer, nostalgia is novelty, says fashion designer Sabyasachi Mukherjee. He goes on to explain that the millennial consumers are far more inspired by our culture than the older generation or their parents. According to him, the paradox is that when everything starts to be modern, the old by default starts to be luxury.
Also, for a generation that has grown up with smartphones and tablets, technology and its progression is a given.
Author David Sax, in the introduction to his latest book The Revenge of Analog: Real Things and Why They Matter writes that on the way to digital utopia, we have begun to fall back in love with the very analog goods and ideas the tech gurus insisted that we no longer needed.
Businesses that once looked outdated, from film photography to brick-and-mortar retail, are now springing to life.
Notebooks, records, and stationery have become cool again.
Today everything is available at the click of a mouse and in large stores. There are no trade barriers. Back in the day, there were a lot of barriers—Coke, Toblerone and Kraft singles were not easily available and were a novelty. In the digital world, music playlists can be created in a few clicks and shared instantly with apps like Spotify.
Mixing cassette tapes is tough. Listening to them requires patience as you can't just skip to your favourite song.
The newness then is in the old. It's probably the 1970's gramophone record that has survived the test of time.
Shop Talk will take a weekly look at consumer trends, behaviour and insights.
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Amsterdam is the most important cultural and artistic centre of the north, representing a contact point for many different spheres of art. Renowned for the Masters from the Golden Age who have settled in the Dutch capital in the ancient 1600s, Amsterdam still plays a key role in the art world. Open for those who like experimenting or seeing and buying the most recent in painting, photography, urban, street art and other media, Amsterdam is the perfect place to spend time and money in. Skip the big museums! Amsterdam is full of galleries showcasing mind-blowing contemporary and urban art. We've made a list of the ten most noteworthy. Enjoy!
The GO Gallery is a professional street art gallery in Amsterdam, known for its many exhibitions in the genre. It is located near the famous 11 meter high drawing of the artist duo The London Police, in the center of Amsterdam. It is led by Oscar van der Voorn and Farud Cambatta, who follow the work of the clients they represent for years and provide an open platform for them to exhibit. In addition, the GO Gallery offers its space in a suitable ambiance for meetings, product presentation or even a cocktail party, be it for business or pleasure.
If you are looking for art, pay a visit to Isabelle Vroom and Olivier Varossieau's gallery because it brings the most exciting works in the fields of urban contemporary and street art movements, from internationally acclaimed stars to the best upcoming talents. Look for Art Gallery was founded in 2010, and ever since organizes ambitious art projects in its friendly and creative environment. Isabelle Vroom and Olivier Varossieau also offer advisory services to their clients, encouraging them to collect art not only from the exhibitors they represent but also from the strong secondary market.
Upstream Gallery is an internationally oriented platform specializing in contemporary art, founded by Nieck de Bruijn in 2003. The venue quickly positioned itself in the Amsterdam art world as a daring place that showed young, promising and sometimes rebellious artists. During more than ten years of its existence, the status of Upstream Gallery and its exhibitors has shifted from talented and promising towards more well known and established. It is precisely this mix of undiscovered young talent and bigger names that keeps the exhibition program of Upstream Gallery always in the fresh and interesting news.
W139 is a presentation and production space for contemporary art, located in the heart of Amsterdam's famous red light district. It runs primarily on the ambition and energy of performers, making it primarily organized as an artist-run space. W139 was founded in 1979, in the space that was originally a theater, by a group of young artists who wanted to present an alternative to the collections and exhibitions on show at the city's museums and commercial locations. In the course of 34 years, W139 has evolved from an anti-establishment squat into a professional non-institutional platform for contemporary art. The program includes both Dutch and international exhibitors who are invited to develop a new (site-specific) work for the W139 area. Today, W139 operates parallelly with, rather than in opposition to, the more established exhibition venues.
Radar is a project created in 2008 by Marco de Piaggi who considers it an "avant-garde monitor". Its aim is identification, creation and exhibition of artistic forms such as sculpture, painting, printing, photography, architecture, video art and music. Radar 'captures' all creative forms that are at the same time radical, actual and urgent. For this reason, Radar is constantly looking for young artists who are taking their first steps in this direction. The ones represented by Radar are Nisja, Laser 3.14, Marcel Ozymantra, Dirk Polak, to name but a few.
The newly named Gerhard Hofland Gallery in Amsterdam is one of the best in the city. It was founded in the autumn of 2000 by Gerhard Hofland. Since then, it has participated in numerous art fairs as well as organizing exhibitions in collaboration with other locations and museums worldwide. Gerhard Hofland Gallery is dedicated to emerging and mid-career artists striving for museum recognition and wider reputation. All of the represented ones have a strong, outspoken formal language in their work.
Fons Welters Gallery opened its doors in 1988. Located in the heart of the Amsterdam gallery district, it focuses on emerging stars. If you are an artist who has just begun to build a career, this is the right place to start, because Fons Welters Gallery's primary aim is to work with artists in the early stage in their professional development. Besides working with Dutch exhibitors, the attention of the gallery is also focused on clients from outside of Netherlands. Almost all of the ones represented started their career at the gallery, and many of them have now entered the international arena. Fons Welters Gallery exhibits cutting-edge contemporary art, from painting through sculpture and installation to multimedia. Since September 2000, the front space of the gallery has been turned into a small project space, called Playstation. This space features younger performers, fresh from the academies, who are offered an opportunity to exhibit their works.
This small, unpretentious but very active gallery is located on the Signel canal in the centre of Amsterdam. ArTicks Gallery is specialized in contemporary street and urban art, featuring original works by both international and local exhibitors. The shows at ArTicks Gallery are designed and curated with an eye for skill, passion and humor. Its team of artists is rapidly growing, representing several artist collectives from Amsterdam such as Codex Inferno, Mokum Zoo, IKS Crew, Hot Mama Hot, Free Jordan Fighters. It is also a place of contact for individual artisans, both within and outside of Netherlands, like Merijn Kavelaars, Marc Zedone, Replete and Steven BLADE Ogburn, among others.
This Amsterdam urban art gallery has a reputation for being secretive. In the "about" section on its website you'll find only this: The Garage is a 17th century carriage house in the canals of Amsterdam. We work with select international artists to put on private, high-end, low-key shows. The Garage gallery hosts exhibitions from local, national and international artists. Rumor has it that the only way to know about the next event at this canal-side gallery is through its newsletter, if you sign up to it, of course.
BE UNAFRAID. BE UNRULY. That's what the guys from Unruly Gallery in Amsterdam demand from themselves, its members and the public. The owner and gallery director are artists themselves, so they have a point of view closer to the exhibitors than most gallerists. The Unruly Gallery makes art and sells art. It opened its doors, which constantly change look as they are always painted by the artist presented, in May 2011. The founder is Niels Shoe Meulman who has solid roots in the graffiti art scene of the 1980s. Meulman began tagging 'Shoe' in 1979 and became a graffiti legend by the time he was 18. He revolutionized the art of writing with Calligraffiti, an art form that fuses calligraphy and graffiti. In the eighties he formed the Crime Time Kings with Bando from Paris and Mode2 from London. Together they gave graffiti in Europe its own distinctive style. In the nineties, Meulman ran his own design company, Caulfield & Tensing, and was partner in the advertising agency Unruly, which he later turned into a brand for silk scarves and a gallery. Most of the artists represented by Unruly gallery are in some way related to Meulman's personal network. Some of them, who have exhibited in the past two to three years at Unruly are Nug, Egs, Paul du Bois-Reymond, Vincent van de Waal, Wayne Horse, Petro, Pane, Adele Renault, and Rae Martini. The artisans to be promoted in 2014 are Mode2, Bando and Shoe.
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Amsterdam, Netherlands


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Whit Stillman's 'The Cosmopolitans' Will Return to Amazon
Posted on Friday, January 29th, 2016 by Jack Giroux
This week Whit Stillman's (The Last Days of Disco, Barcelona) newest film, Love & Friendship, premiered at the Sundance Film Festival. The Jane Austin adaptation received positive reviews, including one from our own Angie Han. The rest of us will see the film later this year, thanks to Roadside Attractions and Amazon, but Love & Friendship might not be the only collaboration we see between Stillman and Amazon this year. Hit the jump to learn more about the Whit Stillman amazon show.
In 2014, Stillman wrote, directed and produced The Cosmopolitans. The pilot premiered almost a year and a half ago on Amazon, but since then we haven't heard whether it would lead to a series. The pilot starred Chloë Sevigny and Adam Brody, following a group of Americans searching for love in Paris. It was a delightful pilot — a brisk, clever look at a group of friends. Even if Stillman didn't write or direct another episode of The Cosmopolitans, the pilot would still entertain as a standalone piece.
Speaking with Collider at Sundance, Stillman said we will see more of these characters on Amazon in the near-future:
I explained to Amazon that I don't like outlining or projecting what something's going to be. I like to allow a story to arise as I'm writing scripts. I find it horrible when I try to think of something for the plot without really being on the ground and seeing where it goes. I was really resistant to do the mini-bible. So I gave them something, but I really didn't want to do it that way. They also knew about the film (Love & Friendship), so they commissioned six scripts for the first season that they were going to let me postpone until I finished this film, which is now. So in ten days, we'll be full on with that. It's been really good because I think I was waiting for the idea I really want, and I think I have that now. It's not exactly Paris, it's a European idea. So it will be Chloe and Adam Brody. We'll keep the pilot, that's part of the story, but we'll be going a different place with it.
Stillman saw the pilot as "its own Saturday afternoon/Saturday evening piece." The episode featured the writer's signature charm, with a light atmosphere, clever dialogue, and plenty of sweetness. The Cosmopolitans presented a group of characters you'd want to follow around on a Saturday night, and more than once.
Love & Friendship opens in theaters May 13th.


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1007 172 Victory Ship Way, North Vancouver Listing #: R2478755
Imagine the feeling of owning in this vibrant & desirable Pier Waterfront Community. Amenities such as Seabus, Quay Market, variety of restaurants, great selection of craft beer establishments, newly opened Shipyard with an array of shops, services, eateries, summer waterpark, winter ice rink, Spirit trail and much more all at your door step. You get to enjoy Pier Hotel's 5 lane 80' pool, whirlpool, sauna, steam, gym, pilate, yoga, spin room overlooking huge sundeck, active harbour and postcard city view. Your Atrium designer quality 1 bedroom home with efficient open plan, 9' ceilings, stainless steel appliances, eng. hardwood floors, A/C, crown molding offers large balcony while savoring your morning tea, evening wine, BBQ or spectactular sunsets. Call NOW for Private Viewing.
Taxes (2020): $2,015.44
- Exercise Centre
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Listed By: Anson Realty Ltd.
Disclaimer: The data relating to real estate on this web site comes in part from the MLS Reciprocity program of the Real Estate Board of Greater Vancouver or the Fraser Valley Real Estate Board. Real estate listings held by participating real estate firms are marked with the MLS Reciprocity logo and detailed information about the listing includes the name of the listing agent. This representation is based in whole or part on data generated by the Real Estate Board of Greater Vancouver or the Fraser Valley Real Estate Board which assumes no responsibility for its accuracy. The materials contained on this page may not be reproduced without the express written consent of the Real Estate Board of Greater Vancouver or the Fraser Valley Real Estate Board.


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For Singapore's GCE O/N Level Students taking the 7088/7175 Syllabus.
The biggest misconception about Principles of Accounts is that there's alot to memorize to do well. Master Principles of Accounts is a step-by-step guide to excelling in Principles of Accounts without the memory work. Use this book side-by-side with your teachers' notes and school practice questions and witness the dramatic returns on your revision time - in confidence and grades.
Trusted By Schools. Recommended By Teachers.
We poured through some 2,500+ pages of school notes, teachers' resources, CAs, SAs and prelim papers to unearth the tactics, tips & tricks top students used to master principles of accounts.
Over 200 copies of the book are distributed through school teachers and classroom orders - in whatsapp groups and bulk school orders.
In this Study Guide You Will Discover...
The universal hidden approach behind the top POA students
Commonalities of top POA scorers and how you can use them to distinguish yourself
Time-saving short summary notes for laser-focus revision
Checklists and focal points for each chapter PLUS an all-in-one appendix containing ALL essential ledger and statement formats for fast and easy referencing for revision!
How to avoid the most common POA exam mistakes
Escape common mistakes made during the exams and maximise your returns on time revising POA
Step-by-step techniques for answering tough questions
Bank reconciliation, commentary for financial ratios – discover the easy way to do these long, time-consuming questions.
Sample exam questions adapted from the top POA schools in Singapore
Yours to "swipe" and benchmark against quality exam standards.
.... And much, much more!
Master Principles of Accounts is your indispensable study guide to revising your POA exams fast, effective and help you jump grades like magic.
Get a taste of what's the REAL Deal. Download a sample chapter.
"I find Caleb's lessons and guidebook extremely useful in my assignments. Caleb has been very enthusiastic and encouraging in every lesson, clarifying our doubts no matter how long it would take. I am able to understand the topics better from the explanations, which has really helped me when I put them to practice. The guidebook is very helpful in helping me with my homework as it explains clearly my misconceptions and in my revision. I recommend any POA student to buy that book as it really helps. Thank Caleb for all your determination, believe and help! Cheers!"Leon Chew
Bedok Green Secondary School (C6 MYE -> A2 O Levels)
Before I met Caleb, I was really at POA and I kept getting E8-F9. At that time, POA is one of my worst subjects. All the concepts and calculations were very foreign to me and there was nothing I could understand.
After I met Caleb, everything became clearer for me because I felt that his teaching method was very authentic. He helped me a lot especially on the depreciation chapter.
Moreover, his book was really useful and basically summarized everything we needed. He interacts with students and makes an effort to make the class fun and enjoyable by cracking jokes once in a while. All in all, I definitely feel more confident for the O level POA paper after I attended his tuition.Tammy Sim
Paya Lebar Methodist Girls School, 2016 (F9 -> A2 O levels)
The Book
- A physical copy of Master Principles of Accounts
- A bonus POA membership site with additional POA practice papers, theory notes and email updates (ready in June 2016)
Caleb Ho, B.Acc (Nanyang Business School, NTU)
Caleb Ho is a POA Tutor, author of a best-selling study guide, award-winning business interviewer (Spirit of Enterprise) and host of one of the premier ideas/education events in Singapore. In his 10-year teaching experience, more than 80% of his students who join him with D7s-F9s for POA have emerged with As and Bs using his 'Jump Grades' systematic approach. His views on tertiary accounting education were also sought and published by The Straits Times, April 2015. With a network of 400 Singapore accounting teachers and trainers built over the past decade- he has access to the latest developments and resources to keep abreast of the latest changes in the POA syllabus across secondary schools to postgraduate levels. What differentiates his approach in teaching Principles of Accounts is his ability to effortlessly translate textbook accounting concepts to real life application. As a former partner of a local bookkeeping company, he has intricate understanding of how accounting can be used to forecast the destinies of small businesses, having worked with some of the top Singapore SMEs and partnered the biggest names in accounting software including Intuit, Singtel SME marketplace and many more.
Ravpreet Kaur Mann, ACCA Affiliate
Ravpreet Kaur Mann is the A-for-POA specialist and the anchor POA tutor for students in the Woodlands, Yishun and Sembawang areas. Known for her highly organised approach, she strategizes classes to be in tandem with the school teachers' speed so that students are able to grasp knowledge easier in class.
Having taught in mainstream schools as a POA relief teacher, Ravpreet hones her acumen in reading students' and teachers' challenges in a classroom setting. Her uncanny ability to see the struggles from her students perspective has also won her respect and spark her students' desire to learn POA on their own.
Ravpreet is married to a lawyer and has plans to establish her POA training business in Kuala Lumpur, Malaysia.
The Book
- A physical copy of Master Principles of Accounts
- A bonus POA membership site with additional POA practice papers, theory notes and email updates. (ready in June 2016)
You have 60 Days (more than enough time to go through the entire guide) to see if Master Principles Of Accounts is the "real deal" or not. If you ever feel that it wasn't worth your money and I will send you a full, NO HASSLE refund for your investment!
There is no risk whatsoever on your part. Just tell us why you are not happy with the purchase via Whatsapp or email and you get to keep the book for free! The burden to deliver is entirely on me.
Frequently Asked Questions
Who is this book for?
This book is valuable for any POA students and teachers who wants to navigate the concepts taught in class or during tuition without fumbling through the thick textbook.
Its 170mm x 210mm dimensions (just slightly bigger than A5) allows students to carry the book around for easy reference.
It's a very unique/beautiful book cover your have - doesn't look like a typical study guide. I love it. What's with the design?
Well, I'm glad you asked. The final book cover was chosen by some 265 students and teachers who vote out of 63 designs submitted from over 4 rounds of design contest. The teachers and tutors chose a safer looking cover. Our students voted this one.
And since the book is written primarily for the student, the decision was pretty straightforward. 🙂
What should I do if I'm dissatisfied with the book?
If you're dissatisfied with the book in any way after purchasing it, just send an email to email@example.com within 60 days of your purchase (keep your proof of purchase!) and we will give you a full refund**. No questions asked!
**refund valid only for the physical book
Is there bulk discount if I buy with my friends/for my students?
Yes. Group buy or bulk purchase for your friends/students will attract a trade discount*
Agreements with the distributors don't allow me to publish these attractive rates online but please write to us. We will advise via email.
*yes, Caleb and Ravpreet practice what they teach.
Which package should I buy?
We believe that you should buy the highest-value package because it will help you the most and give you extra resources to catch up massively with the rest of the pack that's ahead. That being said, the package you should buy depends on your budget. If you have the budget to buy the highest-value package, then go for it. But, just buying the book is also a great option. The book itself has more than 150+ pages of actionable step-by-step advice to help you get your first grade jump.
Who are the authors of the book?
The authors of the book are Caleb Ho and Ravpreet Kaur Mann. Caleb is an Nanyang Business School (NTU) accounting graduate, former partner of a bookkeeping company serving Singapore's SMEs and the current Chief Education Officer at Jump Grades Education. Ravpreet graduated from ACCA and is the A-for-POA specialist and assist students struggling with the subject in the Woodlands/Yishun/Sembawang areas.
I bought the book at Popular and only saw these high-value packages when I went online. What should I do?
Yes - we understand this happens and we can do a top-up-for-the-difference arrangement so you can take advantage of the packages - especially the holiday revision packages. Please reach out to us at email@example.com so we can guide you through the arrangements.
How will I receive my products and/or services?
For the physical book - please allow 5-7 working days to be mailed to your shipping address. The theory notes and mindmaps will be available for download immediately on receipt of your payment.
If I still have more questions, who should I contact?
Feel free to send an email to Caleb and Ravpreet at anytime with any questions, concerns, or suggestions you have related to the book. We'll answer every email you send us. Please send your emails to firstname.lastname@example.com
(c) 2017 Caleb Ho
Jump Grades Education Pte Ltd
111 North Bridge Road, #21-01 Peninsula Plaza, Singapore 179098
Class Locations: Kovan. Jurong East. Novena. Woodlands.


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The Philippines protested on Tuesday actions by the Chinese coast guard that prevented delivery of supplies to a small group of Filipino soldiers guarding a shoal in a disputed area in the South China Sea.Manila calls China action in disputed waters an "urgent threat"
Manila protested on Tuesday against Beijing's blockade of civilian supply ships in disputed waters of the South China Sea, saying China's latest actions "constitute a clear and urgent threat to the rights and interests of the Philippines". China's coast guard ships had driven away two Philippine vessels, which had tried to approach a shoal in the South China Sea on Sunday, sparking the latest flare-up in a long-running territorial dispute.
The Department of Foreign Affairs summoned China's charge d' affaires Sun Xiangyang on Tuesday to hand over a strongly worded protest over the incident in the waters around the Second Thomas Shoal, which the Philippines refers to as the Ayungin Shoal.
In a statement, the foreign ministry "urged China to desist from any further interference with the efforts of the Philippines to undertake rotation and resupply operations at the Ayungin Shoal."
"Ayungin Shoal is part of the continental shelf of the Philippines and (it) is therefore entitled to exercise sovereignty rights and jurisdiction in the area without the permission of other states," the foreign ministry said.
The shoal, known in China as the Ren'ai reef. Chinese Foreign Ministry spokesman Qin Gang said the Chinese patrol ships warned the Philippine vessels, carrying construction materials, not to intrude further into the waters around the reef and they left the area. China's claim over islands, reefs and atolls that form the Spratlys, a group of 250 uninhabitable islets spread over 165,000 square miles, has set it directly against Vietnam and the Philippines, while Brunei, Taiwan and Malaysia also lay claim to parts.
The South China Sea provides 10 percent of the global fish catch, carries $5 trillion in ship borne trade a year and its seabed is believed to be rich with energy reserves. Manila ran aground an old transport ship on the reef in 1999 to mark its territory, and has stationed marines in abject conditions on the rusting ship. The Philippines also occupies eight other features in the disputed Spratlys.
The Second Thomas Shoal, a strategic gateway to Reed Bank, believed to be rich in oil and natural gas, is one of several possible flashpoints in the South China Sea that could prompt the United States to intervene in defence of its Southeast Asian allies.
In 2010, Manila awarded an Anglo-Filipino consortium a licence to explore for gas on Reed Bank, but drilling stalled in 2012, because of the presence of Chinese ships. Manila says Reed Bank, about 80 nautical miles west of Palawan island at the southwestern end of the Philippine archipelago, is within the country's 200-nautical mile (370 km) exclusive economic zone.
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International Fun-Shop
Ben Nye Fresh Scab
Fresh Scab by Ben Nye is an authentic brownish-blood tint for older, dried blood clotting effects. Fresh Scab blood doesn't completely set but the outer layer scabs over. Washable. May stain some fabrics; test before use.
- Expect 10-35 applications per ounce
- washable
- may stain some fabrics
Katt's Review
April 15, 2015
Works wonderfully! Definitely would buy.
Greg's Review
September 27, 2015
Great product for quick scratches and cuts. Also great for burns, if you buy the Ben Nye Charcoal Powder as well. What you do is take a spatula or popsicle stick and smear a nice layer of "Fresh Scab" onto the area you want burned, then take Ben Nye Charcoal Powder and dust all over the "Fresh Scab". Take some water on a paint brush and start to rub and take away areas of the charcoal powder and fresh scab. You will start to see the burn appear right before your eyes! Mess around with it, you could do some cool stuff with it. Good Product!
Maddie's Review
October 27, 2015
Absolutely love it! Although, a few months into owning and usage, it being mixed caused it to become runny. Only downfall is long hair sticking to it. Other than that, totally worth the money.
Hanz Vonder Lou's Review
November 02, 2015
I must say, Ben Nye outdid themselves for making this product. I must say that this products looks surreal perfect for that fresh wound effect. Did a scar makeup and added Ben Nye's Fresh Scab and Voila! Never failed to amaze me.
Sheena's Review
March 15, 2016
This is great stuff! Wonderful to use when filling in cuts and gashes, as well as to stage blood for blood clots. Worth the money, that's for sure.
Stevie's Review
September 08, 2016
It really looked like scabs
Hannah's Review
July 02, 2018
I am in love with this product! It works great for creating scratches and depth in a wound. I would recommend this product along with the stipple sponges for creating the perfect scratch!
Makena's Review
October 26, 2018
I love this stuff. Very realistic color and texture.
Janine's Review
November 17, 2018
I use this on lots of my makeup works, and it never lets me down.


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Rangers on the Right Track
Brad Richards, photo courtesy of MSG Photos
But they remain a player away
The Rangers head into this season coming off an 8th place finish and another first round playoff exit—the team's second under head coach John Tortorella. 2011-2012 will be the teams third full season under the fiery Tortorella, and it's clear the organization has its eyes on getting out of the 1st round of the playoffs, something the Rangers have accomplished just twice since the lockout.
This year, the team will have a shiny new toy added to the mix—expensive free agent Brad Richards. The 31-year-old Richards signed a 9-year deal worth $60 million this offseason. But the fact that Richards will be on the Rangers roster until his 40th birthday is not what Rangers fans should be focused on.
Richards, at his best, is capable of a point-per-game pace—something he's done each of the past two seasons—and his playmaking ability should help much maligned sniper Marian Gaborik, and a power play that at times last season the team would have been better off forfeiting. If that's not enough, Richards is familiar with Tortorella, having played under him the first seven seasons of his NHL career, and is a winner, taking home the Conn Smythe trophy as playoff MVP when his Lightning won the cup in 2004.
In addition to Richards, the Rangers will be counting on several young players to raise their games this season. The team will hope newly minted captain Ryan Callahan can stay healthy and make a run at 30 goals, and that fellow forwards Brandon Dubinsky, Artem Anisimov, and Derek Stepan continue there maturation. On defense, the blueshirts will look to Marc Staal to continue rising up the ranks of the top d-men in the league, hope Michael Sauer and Ryan McDonagh avoid sophomore slumps, and welcome highly touted youngster Tim Erixon into the fold.
It's a solid, hard-nosed lineup that will bring it every night (or risk facing the wrath of Tortorella), but one that should hardly be among the odds on favorites to win the Stanley Cup. The Rangers are still a team that lacks the top end skill necessary to be counted amongst the league's elite. As long as Gaborik rediscovers his scoring touch and Richards proves his concussion last season is a non-issue, the Rangers will be better, and are a safe bet to be in contention for 4th place in the East and to win a playoff series, but anything more than that is a stretch.
The Rangers simply do not have the firepower the leagues elite teams do. Teams like Washington, Pittsburg, Vancouver, and Tampa Bay all would win a battle of skill over the Rangers. But building a championship team is a process, and with adding Richards to their young core, the Rangers are a step closer to completing that process.
Where could the skill players capable of putting the blueshirts over the edge come from? Could it be on their own roster in the form of the talented but enigmatic Wojtek Wolski? Maybe, but probably not. In reality the team will have to bank on either a midseason trade, or wait until next offseason when more money comes off the books—an offseason that figures to include highly touted prospects Chris Kreider and Christian Thomas challenging for roster spots. Until then, Rangers fans are encouraged to remember that building a winner takes time, and for the first time in a long time, the Rangers appear to be on the right track.


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The Hermitage of Ntra. Sra. De Butarque in Leganés is a small church with a single nave, in which Audio-Technica and Apart Audio products have recently been installed.
Apart Audio MASK6CT loudspeakers were installed as they integrate perfectly and are very versatile in installation with many possibilities of angle and placement both vertically and horizontally. MASK6CT presents a unique design and offers crystal clear sound for all types of applications. MASK6CT can be used with 70V and 100V lines, with transformer tappins 6-15-30-60 watts at 100V or with 16 ohms at low impedance. Incorporating a powerful 6.5" coated paper cone and a 1" silk dome tweeter MASK6CT offers high SPL and extremely low distortion. The built-in 3-step protection, exclusive to Apart Audio, and the high quality components make the MASK6CT an ultra reliable and safe speaker, even working with high power levels. With the revolutionary design of ClickMount bracket, MASK6CT is undoubtedly the easiest and fastest speaker to install on the market. ClickMount's predefined clicks ensure perfect alignment for each speaker, the discrete cable management system, integrated bubble level and input and link connectors make the product a dream to install.
The installtion company Iberloud, said that the results were excellent, leaving the clients fully satisfied, and affirming that this configuration is presented as an excellent solution to update existing installations.


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Nurturing Your Soul to Thrive with Passion!
I needed to build my personal strength. There was so much going on in my life and I felt overwhelmed. At first I was skeptical about Yudy's approach because the concept was new to me, but she was able to give me the clarity that I needed to believe in my inner strength and that we are all capable of believing in ourselves.
I have a deep connection with Yudy and would highly recommend her. She and I have a deep passion for what she does helping our children.
Our mission is to create a future where people are no longer the victims of circumstance, but are in control of their own lives to fulfill their purpose. We are committed to empower leaders and change agents to transform themselves, their organizations and their community from a life that is mindless to mindful, so that we create a planet of more conscious and empower human being!
"You have the power to transform yourself to create a new identity for a happier and more fulfilling life that is worth living!" ~ Yudy Veras Bueno
Copyright - Yudy Veras Bueno and Joy Holistic Wellness
Transformational Coach - Emotional & Spiritual Guide
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So don't speak about low salaries of poor Moscow's people.
Many people outside of Moscow live ONLY for their salary as they have no such possibilities to take additional money like the Moscow people. A few days ago a reporter spoke to a Moscow woman-pensioner " I think you have got some savings. In which currency do you keep them?" The pensioner answered: "yes, I have got some savings. I have got only 3,500 US$"
She was a pensioner!!! Pensioners outside of Moscow got 2-3 thousand roubles (~ 80-100 US$) per month.
Zazhralis oni tam v Moskve...


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Longer blades plan for 'Lincolnshire's biggest wind farm' sparks new protest
Credit: Lincolnshire Echo | February 29, 2016 | www.lincolnshireecho.co.uk ~~
Wind farm protesters are gearing up for a new campaign because a power firm wants to increase the diameter of blades which are already the length of a football pitch.
Residents claims they had no idea the changes were being asked for at what's being dubbed Lincolnshire's biggest wind farm, which will generate electricity.
The plans for 22 turbines were submitted by Ecotricity and planning was approved by the Government in 2013. The development will be built at East Heckington Fen – half way between Boston and Sleaford.
But Melvin Grosvenor, from the new campaign group Heck Off, said that although the developer had consulted on changes to extend the blades, many residents knew nothing about it.
They are now organising a meeting to create an action plan to effectively get their point of view to decision-makers and the developers.
He said: "It will be the biggest wind farm in Lincolnshire and there was a lot of opposition to it at the time it was submitted.
"The blades they have permission for are 90 metres in diameter so each blade is 45 metres long and they want to increase the blades to 103 metres in diameter – that is 6.5 metres on each blade, so the distance off the ground is only 22 metres. That is significant as we have seen they cause noise issues.
"The new variation has gone back into consultation and a letter has come from the Department for Energy and Climate Change and it asked everybody who was informed to let it know their thoughts by February 10."
Mr Grosvenor has written to complain about the development to the Department for Energy and Climate Change.
A meeting is due tomorrow night at The Hume, South Kyme, at 7pm, to create an action plan aiming to get resident's point of views across.
It is believed up to 200 residents could be affected by the development.
Mr Grosvenor added: "Residents did not know the consultation had reopened and the letter that went out was only delivered to people living in the North Kesteven area.
"We have to re-open the consultation, we have to make as much noise about it as possible – the people who should have responded didn't even know about it.
"Local communities should be heard."
One of the residents who will be affected by the wind turbines is Chris Jones. He lives in Sleaford but his business, Get Knotted Furniture, is based in Heckington.
He said: "I think the plans need to be made crystal clear about what they are going to do and people should be made aware of it.
"They are a debatable item but they are like pylons and people are used to seeing them now – we need to move forward with the times."
North Kesteven District Councillor, Stewart Ogden, who represents Heckington added: "It is always good for people to have their say about anything, whatever their opinion they should always be heard."
A second meeting is to be held by Heck Off at 7pm on March 3 at Hubberts Bridge Community Centre.
This article is the work of the source indicated. Any opinions expressed in it are not necessarily those of National Wind Watch.
The copyright of this article resides with the author or publisher indicated. As part of its noncommercial effort to present the environmental, social, scientific, and economic issues of large-scale wind power development to a global audience seeking such information, National Wind Watch endeavors to observe "fair use" as provided for in section 107 of U.S. Copyright Law and similar "fair dealing" provisions of the copyright laws of other nations. Send requests to excerpt, general inquiries, and comments via e-mail.
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There is a keen difference between having an analytical mind and a compulsory need to indulge in interpreting every detail of every event (or non-event) that one comes across. Too much effort spent on discovering the hidden nuance in a tossed-off phrase quickly gets in the way of understanding the moment. Treating life's every-day occurrences as mini-conspiracies that must be revealed in full can cause the sort of mind-trap that prohibits an individual from being able to revel in the beautiful mysteries that life is actually throwing at us every moment. Sometimes, being able to let go of the need to "know" everything can actually open up a world of understanding, awareness and appreciation.
And then there are people like R. Salvador Reyes. An accomplished poet, he has spent some time on the observation of the minutiae. When I first encountered his fragile, emerging prose nearly thirty years ago, it was apparent that he was interested in deeper themes and unseen details. Continue reading Over-Thinking Is a Bad Practice (But a Fine Profession)


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"Keeping Markets Open for Trade and Investment"
Organisation for Economic Co-operation and Development (OECD) Ministerial
June 25, 2009
Paris, France
It's my pleasure to join you for the first time at the OECD. Now, all of us are here because the OECD has a critical role to play in helping us advance our shared agenda of ensuring a strong and dynamic global trading system that can generate sustained economic growth and overcome the challenges of this current global economic crisis.
For example, the recent OECD Participants agreements to extend terms and make repayment profiles more flexible for nuclear and renewable energy production projects are a major policy success. They create strong financial incentives for investments in energy sources that can help us achieve our broader energy security and CO2 reduction objectives. We should all be proud of this collective accomplishment.
We should also encourage the OECD to enhance its positive and supportive work on intellectual property. Adequate and effective IPR protection and enforcement is critical to innovation and economic development. And this should be reflected fully in ongoing discussions with accession candidates, as well as in OECD projects such as the Innovation Strategy.
But despite some stabilization of financial markets, concerns about the near-term performance of the world economy continue to be pervasive. The World Bank just released growth estimates for the world economy for this year, forecasting a 2.9 percent decline in global output and a 4.2 percent decline in the output OECD countries. Most developing, as well as developed, countries are being affected. And while many now foresee some recovery, the timing, strength and extent remain uncertain.
The response to the financial and economic crisis itself has been global. This is not a North-South issue. In the United States, we continue to be engaged in a number of very large scale efforts to stabilize our markets and help restore growth to our economy and, by extension, the world's economy. Other countries are also engaged in similar efforts. But in an open and integrated economy, such steps at the national level, particularly when reinforced by appropriate policy action, are central to restoration of global economic health.
Now, I am keenly aware of the contraction in world trade now occurring. The WTO estimates that global trade will decline by 9 percent this year, the sharpest decline since the Second World War. And though trade may be contracting, however, economic recovery will mean that trade will have to expand. Thus, it is imperative, in this time of economic turmoil, that we work together to keep our markets open. As our WTO Director-General Pascal Lamy has stated, trade can and should be a potent tool to help lift the world out of this economic doldrum.
At the national level, we need to work to keep vigilant about how we respond to this economic crisis. We think the last WTO report on responses to the crisis actually shows the situation better than some predicted. And we thank the WTO for giving us a rules-based system to review procedures and the very visible individual monitoring of countries that is needed.
At the global level, all of us here today, OECD Members and observers, must commit to reaching an ambitious and balanced conclusion to the Doha Development Round and build on the progress already made and find new approaches to make substantial progress toward the conclusion of the Round. Successful conclusion of the Doha Round can be a critical element for reviving trade and breathing new life into the world's economies. And we need to build on our multilateral efforts through direct, bilateral engagement with one another to move to the final phase of negotiations as quickly as possible. What better way is there to assure that trade once again becomes an engine of growth and better economic futures for all than the conclusion of this important multilateral round?
We all know that the economic situation demands a Doha outcome that delivers for all the world new and real market opportunities. The United States is ready to do our part. President Obama and I are fully committed to achieving an ambitious and balanced Doha outcome. And I invite all of you to join us in the upcoming weeks to explore ways to move forward to a successful conclusion.


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Hi there, We would like to announce that we are on 500px and we are showcasing some our work there and you can explore the 500px for new collection of favorites pictures.
Category Archives: Blog
Blog posts, bts, new projects and more.
I know this is the 1st of April, and this is not a prank for those who know the old site, and i had to close it for maintenance because of the many issues of it. I'm struggling to decide for the new them and style for our web site because the old one was not responsive for mobile and tablets. In our days 72% of the population use tablets and mobile phones for web browsing. I have to admit the guys form pixelgrade are awesome, they have a great support and some awesome themes for site which they support many devices, and widgets. You my dear visitor enjoy your stay and give us a thumbs up if you like our work or you can contact us.


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Parents around the world have all experienced the struggle of trying to take their kids temperature, but soon there could be an app for that. "Fraden Corporation has been granted a patent that may in the future allow the smart phone to become an accurate medical diagnosing instrument that, without physical contact, can instantly measure someones temperature."
The way this would work is the app on the phone would detect the intensity of the invisible infrared light. The infrared sensor would be located next to the camera. One must hold the phone about 1 inch away from the baby's or patient's temple. The phone will then just take the temperature and the result is there within a second.
Not only is this invention fast-resulting and very easy to use, it is also very convenient and hassle-free. The best part about the infrared thermometer is that if you have your phone, you have your thermometer. Also, there is no physical contact, which is probably the feature that parents appreciate the most, because no one likes to see their baby cry.
This product doesn't just measure the temperature of people, it also can determine the temperature of a surface such as a stove, baby's bath water, or even something in a science lab experiment. The infrared thermometer has a wide range in which it can measure. Starting at -22 ºF, it can measure a max temperature of 400 ºF. As you can see, the infrared thermometer is a breakthrough in not only technology but also health and safety, because it does have the potential to save lives.