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Networking made simple, good, and automated'"on the heart of healthcare innovation. Downward canine is a unbelievable train for the lower back muscle tissues and the hamstrings (the muscle mass behind the knee). Downward dog stretches the muscle mass that your again needs. Moreover, downward canine is helpful for getting old females over 40. Females over forty have a high chance of experiencing a frozen shoulder. The name frozen shoulder does not do the sickness justice as a result of it is extremely painful and almost fully debilitating. Stretches are key to stopping injuries. A regular train program equivalent to yoga is great for both the thoughts and the physique.
Patient engagement in their health has is the root of implementation of health info technology. The goals for the expertise design have been to improve the provision of health information by means of digital records and to combine it in a meaningful way for sufferers. These efforts progress the necessity to achieve high quality care whereas lowering prices. Giving patients access to EHR allows patients to view their appointments and medications, to enter physiologic information corresponding to blood stress, weight or blood glucose values to promote health and disease consciousness. Nurses are able to assist create and educate sufferers in using these tools to promote patient engagement.
and when you do need insurance from compianies you're employed for is at least one hundred+ out after taxes a pay interval of weekly.hospitals,insurance firms are simply as greedy as the banks,yea free enterprise. Read. Reading printed supplies like your favourite e-book, journal, procuring guide, or your worn out love-letter brings your mind to a unique state of celebration. Your feelings are transported to a spot where it likes to go.
With the Chinese language food regimen being so rich in fruit and vegetables there's little trigger for concern for a nation that has a few of the fewest weight problems cases per capita globally – nevertheless, through the 15 day Chinese language New Yr there is a rising trend among the obese inhabitants of this nation to take care of a healthy diet throughout this celebration.
The malware was circulated by electronic mail; targets have been sent an encrypted, compressed file that, once loaded, allowed the ransomware to infiltrate its targets. Brotaneka JM, Seeley CE, Flores G. The significance of cultural competency usually pediatrics. Curr Opin Pediatr 2008;20:711-8. Authors might order reprints of their articles from the printer once they obtain their copyedited manuscript for assessment.


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Thank you for your interest in our lodge. Please contact us on the following, we would assist you with the greatest of pleasure:
Nsele Safari & Lodge Details
Olaf & Stephanie da Costa
(Owners & Managers of Nsele Safari's Lodge)
Mobile: +27 (0)83 739 2955
Email: email@example.com
Web: www.nsele.co.za
Address: Portion 152 of the Farm Guernsey
81 KU, Hoedspruit, Limpopo
GPS coordinates:
Payment methods: Master/ Visa Credit card, Direct Internet Transfer, Bank deposit. With regret we do not accept cheques/travellers cheques or foreign currencies. To make a provisional booking and avoid dissapointment we need a 50% deposit to confirm a reservation – Some reservation options require full deposit for confirmation, and is non refundable.
Make a booking……

subset: commoncrawl


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Google Mail
As part of Apps at UMass Amherst, students use Google Mail for their UMass Amherst email. The email service is also used by some faculty and staff across campus.
Microsoft Exchange provides an integrated email, calendaring, and contacts experience to select faculty, staff, and graduate students. Exchange is used by faculty, staff, and some students.
UMail, our legacy email system, is available via a Web browser or email software. UMail is used by some faculty and staff. UMail is expected to be retired in early 百姓彩票网.


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People at this week's E3 show were upbeat: There's hiring going on in the video game space, and a feeling the business is getting back on track after the recession. Meanwhile, employers may add a moderate amount of jobs during the summer, and Boston companies need Ruby on Rails developers.
For last week's update, click here.


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Please enter the email address for your account. A verification code will be sent to you. Once you have received the verification code, you will be able to choose a new password for your account.
Via Al Lago 6 - San Vito di Cadore (BL) 0436 9320 / Cell: 347-4348010 / Fax: 0436 643115


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You need an account to watch this video.
In this sweet scene Rebecca gets kissed and cared for until Nicolas pulls his throbbing cock out. It is at that moment that she gets plowed like a cheap whore until he cums all over her mouth.
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Sapphic Teens Francheska & Lyuba Oumski Add A Cock
Francheska Shows Off Her Bright Red Asshole
She wants a cock in her ass she knows how to get it


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More on cartridges and 3d printing
As was explained in the previous blog about cartridges and 3d-printing, 3d-printers build tangible objects by printing layers. So instead of creating a 'flat' word file with letters on it as you would with a normal printer, with 3d-printers you have to create a 3d model. The 3d printer will know how to translate this model into layers. However, how does that precisely work and what kind of cartridges are needed? This blog will elaborate on the techniques used by 3d-printers and the type of cartridges you can choose from.
Broadly speaking there are three steps in the 3d-printing process: modeling, printing and finishing. First you have to create a 3d model. This can be done with different types of software. You can either choose to create the model entirely by yourself, or you can choose to make a 3d scan of an object. With the former method you have more freedom of course, but the latter offers the interesting experience of rebuilding an object you already know as it were. Building a 3d model is not unlike sculpting and scanning an object merely involves the gathering of data. For the average consumer both options can be quite difficult when you don't have experience with it, so it might be advisable to ask help from a more experienced user.
When the 3d model has been built, you will need software that can slice the 3d file. By slicing the object the software translates the object into layers. This is how the 3d-printer knows how to print the object. This is also the moment when the cartridge becomes important. It is not possible to use just any material for your 3d-object. Most printers have restrictions, because different materials need different printing processes. So before you buy a 3d printer make sure that you check out which cartridges can be used.


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UKs leading sign manufacturer. Universal symbol for the emergency fire exit. Clearly indicates Fire Exit. Self-adhesive vinyl. Size: 150x450mm.
Safety Sign Fire Exit Running Man Arrow Down/Left 150x450mm Self-Adhesive E97SS
Use this sign to indicate the position of the fire exits, leaving no confusion in an emergency. The universally recognisable symbol and sign is professional and functional, clearly displaying the fire exits to customers, visitors and employees. This self-adhesive sign measures 150x450mm.
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Veteran Employment Director
Mr. Paul Bill joined Veterans Bridge Home in July 2015 as the Veteran Employment and Education Specialist, after a successful career in Business Development consulting and training, most recently with Mastering Business Development Inc. -MBDi. After a short leave, Paul returned to Veterans Bridge Home to serve as the Veteran Employment Director in July 2017. He is an experienced Marketing and Business Development executive with a passion for revitalizing organizations and helping clients find, understand, and capitalize on all types of revenue growth opportunities.
Prior to joining the MBDi team, Mr. Bill was the Manager, Maritime Business Development for BAE Systems, Land and Armaments Sector, where he led Business Development strategies and numerous capture teams. During this time, he developed a proven track record of performance in operational and sales management. In addition, he trained program managers, capture managers, and fellow Business Development representatives on U.S. Navy and U.S. Coast Guard requirements, acquisition, and leadership profiling.
Mr. Bill is a 30-year retired Commander and U.S. Navy Surface Warfare officer. He served on numerous naval vessels and deployed in support of Persian Gulf War and Operation Desert Storm and 9/11 operations. Mr. Bill was a lead trainer and team builder during all of his command tours. Prior to serving in the U.S. Navy, he was an enlisted SeaBee in the Naval Reserve Officers Training Corps (NROTC) program.
Since 2008, Mr. Bill has served as an Adjunct Professor at Bellevue University in Nebraska, teaching online Marketing and Business core courses for the college's Business Department. He also conducts workshops for separating military veterans transitioning to civilian careers.
Mr. Bill earned an MBA from Webster University and a BS in Industrial Engineering from Rochester Institute of Technology. He is originally from upstate New York.


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FX Network - American Horror Story: Hotel
American Horror Story: Hotel - "Sleep Walk"
Campaign: American Horror Story: Hotel
|Entrant Company
|FX Networks, Los Angeles
|Agency Network
|Firefly Ent., Method, New York, Los Angeles
|FX Network, Los Angeles
|Creative Director/President Marketing & On-Air FX Networks
|Stephanie Gibbons
|Creative Director/EVP On-Air Promotions FX Networks
|John Varvi
|SVP Production & Special Projects, FX Networks
|Kenna McCabe
|SVP Broadcast Design, FX Networks
|Steve Viola
|VP On-Air Promotions, FX
|Carol Weiler
|VP Production & Special Projects, FX Networks
|Julie Graham
|VP Production & Special Projects, FX Networks
|Elizabeth Knighta
|VP Broadcast Design, FX Networks
|Amie Nguyen
|Paul Tolton
|Philippe Bergerioux
This 2016 Clio Entertainment Silver winning entry titled 'American Horror Story: Hotel - "Sleep Walk"' was entered for FX Network - American Horror Story: Hotel. It consists of 1 video and 1 image. This piece is part of a campaign called 'American Horror Story: Hotel' that consists of 4 elements.


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Project Description
Resin Surfaces Ltd
RSL is one of the leading independent resin floor and wall manufacturers in the UK, based in Hazel Grove. We have been working with the senior management and marketing team for the last three years creating and implementing a programme of news releases, case studies and paid for opportunities in trade media to showcase the product benefit to new and existing customers. There continues to be a special focus on the food and drink market and the company's best selling Resuthane range and just launched innovative solution Elladur – a fast cure, quick turnaround product for custodial, retail and many other sectors. Recently acquired by worldwide coatings company Sherwin Williams, RSL has an ambitous programme of UK and worldwide growth to deliver in 2017 which the PR will continue to support with focus on thought-leadership pieces and case studies underpinning resin flooring expertise.


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"I'm a naturalist with a camera rather than a photographer."
Jack Perks is a wildlife photographer based in Nottingham, UK. He is well known for his underwater images, especially those of the different species of British freshwater fish. November this year, I had the pleasure of asking him some questions about his photographic work. Here you can read his answers.
Can you tell me a bit about yourself?
My name is Jack Perks and I'm based in Nottingham and I am primarily a wildlife photographer.
What sort of photography are you specialised in?
I specialise in underwater photography but even in that I specialise in freshwater photography – quite a niche subject to go after.
What is your background as a photographer?
I started off more into nature, cliché to say really, from before I can remember when I was a kid. When I was 16 I did a B-tech course at college, picked up a camera and then went to university in Falmouth and did a degree in marine natural history. But I'm a naturalist with a camera rather than a photographer, I guess. I'm more interested in the wildlife than the cameras. But you obviously have to know the cameras to be a photographer.
"I'm a naturalist with a camera rather than a photographer."
Why did you choose Nottingham as your base, especially after having studied in Falmouth?
I'm from Nottingham, born and bred. Also, Nottingham is a very central county in England. It means that if I need to go north, south, east, west it doesn't take me enormous amounts of time to get there. And from a strategic point of view, there's lots of wildlife surrounding me. I've got the Peak District in Derbyshire, I've got the Lincolnshire coastline, I've got all the rivers in Nottinghamshire for my underwater-stuff. There's lots of businesses and organisations not too far, so it made much more sense. Cornwall is a beautiful county and I would have loved to stay there but you're very isolated in Cornwall. And there is not a big industry there, for anything really, certainly not for wildlife photography. So, it just made more sense to come back.
You do a lot of filming as well – is that more of a side project?
I used to be just stills and that was all I did. But I realised that there's more money in film and most SLR cameras have video on them. So, it's not that difficult for a photographer in this day and age to switch between the two. And I'm finding now that it's about 50/50 – half my time now is filming and the other half is stills. It's becoming more and more part of what I do.
What does the job as a nature photographer entail next to the actual taking of images?
I think, certainly in this day and age, you've got to really have a mixed bag of things to do. Gone are the days where you could just be a photographer for a magazine or just work for one organisation. I think you've really got to do a bit of everything. So, I teach workshops, I do lectures at universities, I do commissions for companies, I do filming, I sell prints, I have a book out… Basically, I do lots of different things because no one of them could really sustain me on its own. Having my fingers in lots of different pies keeps me going.
"I think, certainly in this day and age, you've got to really have a mixed bag of things to do. Gone are the days where you could just be a photographer for a magazine or just work for one organisation."
How would you describe your style?
I guess all photographers have a style of photography even if they don't realise it. And I suppose mine's a little bit non-conformative because I just do pictures that I like to take. Which might sound a bit simple but for example I really like using the fisheye lens. And I use that for everything – whether it's underwater or above land. You get the distortion on a fisheye lens but it's not a problem for me. Some photographers would say "oh, I don't like distortion" but I'm fine with it. I basically do pictures that, one, I like taking and, two, I know that I can make some money of. Any they are my two priorities really. So as long as I fit those criteria that's what I do.
"I basically do pictures that, one, I like taking and, two, I know that I can make some money of."
What kind of camera equipment do you use?
I think everyone thinks professional wildlife photographers have bags and bags of equipment and that they've got all the latest most expensive stuff but it's not always the case. I mean, for a large part of my career I had semi-professional camera gear that was all second hand. It's only recently that I got a full frame camera which is a D750 Nikon. And now I've gone full frame I don't think I could go back, funny enough.
I have a 300 mm 2.8, which is a second hand one. And the underwater camera gear that I use is a D7000 Nikon camera that comes in a housing. Which means that it's kept dry and I can do all the pictures.
I've got little GoPros, tripods and little camera trap stuff, Bushnells, so lots of little bits and bobs but not shed loads of camera gear really.
I also use a D7000 and often have issues when using a higher ISO – do you have similar problems?
Yes, that's why I went for the D750, the full frame, because the D7000 when it first came out was a brilliant little camera but it's rated quite badly now. And the ISO, as you say, is terrible. Once you go over 500 it's like a jigsaw with the noise and the grain. When I got the D750 I was pushing the ISO to 2000 and it was still fine and that's a big relief for early morning photography, overcast day photography which the D7000 didn't cope with at all.
Next to the camera – what do you think is the essential piece of equipment you have?
I tend to be fairly minimalist with what I take when I go out on a shoot. One of the things with long lens-photography, that I found invaluable, is a monopod. I used to be against using monopods – not for any particular reason, I just thought they were useless. But when you've got a big heavy lens, carrying that all day takes its toll. And a monopod takes the weight off it and that makes such a difference, particularly for me as I'm not built like a body builder. Also, you can pan around easily, they're nice and mobile, they make carrying the long lens easier, as you can shove it on your shoulder and they're cheap. I think mine cost me £ 17. So, they're not a lot of money but they're good.
And weather clothing is essential as well. It sounds obvious but make sure you've got thick gloves on if it's cold, waterproofs on if it's going to rain. The biggest tip I can give for photography is, be comfortable when you're out taking the pictures. Because as soon as the cold sets in and you're thinking "oh, I don't want to stay here" you're going to miss the shot or your belly starts to rumble. I normally have a mars bar in my bag, or something like that, just to keep me going. Sounds silly but you will stay out longer if you're comfortable and the longer you stay out the more chance you have to get a good picture.
"Be comfortable when you're out taking the pictures. Because as soon as the cold sets in and you're thinking "oh, I don't want to stay here" you're going to miss the shot or your belly starts to rumble."
Could you describe your workflow?
I take the photograph and then I'll edit it. I don't edit heavily, I just do little adjustments. I do a little bit of cloning but not ridiculous amounts. If there's a twig in the corner I might clone that out but I'm not adding extra rock in or putting loads of trees in the background or anything like that. I adjust contrast and things.
From there Lightroom's really good for keywording. I've only been using Lightroom relatively recently but that's made it much easier to keyword and catalogue images.
And then from there it's not so much me approaching the magazines, it's more that some magazines send out emails, some of them advertise on social media. They might put "We're looking for a picture of…". And then, if I've catalogued it I can find that nice and easy and can ping it across or send them some samples.
When you go out do you go out to take pictures, do you have certain ideas of the image you want to take?
When I first started, I used to just go out with no idea and would just see what happened. Now I prefer to plan quite a bit. I have a shot in my mind and I'll try to go out and I'll try to get as close to that as I can. For example, I want to go and do Bitterns at Attenborough (Nature Centre), I'll think, where's the best place to find them going to be? Where's the best place to make use of the light going to be? What kind of camera gear am I going to need to use? How am I going to frame it? Do I want it close up? Do I want it small in the frame? Just try to think of all the options and I think that pays dividends because you get closer to the better images that you've got in your minds.
"When I first started, I used to just go out with no idea and would just see what happened. Now I prefer to plan quite a bit. I have a shot in my mind and I'll try to go out and I'll try to get as close to that as I can."
Do you have a favourite photo of your own?
I guess one of my most successful photos isn't even a wildlife one, it's a picture of two Jack Russells play-fighting which I took by chance. I saw the two Jack Russells playing and the mum had the puppy up against the wall. Then the photo got turned into a meme and just went viral, all over the internet. It's quite nice to see an image do really well, just, I'd rather it had been a more traditional wildlife one than Jack Russells. But yeah, that's probably one of my favourite ones.
Do you have a photo that you dream of taking one day?
In the UK, I still haven't really got a good underwater picture of a salmon. So that is on my hit-list.
But internationally I'd love to do Great White Sharks. That would be amazing too. I'd probably do it in a cage, I don't think I would be brave enough to swim along but just being underwater and getting a photo would be spectacular.
Do you have any advice for people interested in nature photography?
Wildlife photography is a difficult profession to get into, it's not an easy one at all. But there's always opportunities out there if you look. I find social media really crucial for that sort of thing and for connecting with people.
The main thing, I would say, is get some sort of niche, specialise in something. Because the trouble is, there are so many talented photographers and a lot of them don't even make money out of it, they just do it for themselves. They are doing things like birds and mammals and whatever and that's all covered. But how many slug photographers are there? How many slime mould photographers or moss photographers? It doesn't sound exciting but I bet there are very few photos out there so there is probably more of a market than you think for that sort of thing. It's photographing the things that haven't really been photographed before, specialising in it and making it your own.
"The main thing, I would say, is get some sort of niche, specialise in something. […] It's photographing the things that haven't really been photographed before, specialising in it and making it your own."
And that's sort of what I did with freshwater fish. Before me, people have done it, I'm not saying I'm the first one to do it, but I think I'm the first person whose really got in there and done a lot of freshwater fish and specialised in it. And I've made that into a nice little part of my work now. So if you want to get into wildlife photography, find a niche.
Overview – Jack Perks
Working location: Eastmidlands, UK
Speciality: Underwater Photography
Jack's book: Freshwater Fishes of Britain
Website: www.jackperksphotography.com
Blog: www.jackperksphotography.com/blog


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I am trying to compute median household income in various zipcodes based on buying habits. While implementing the dataflow, I am now stuck in the Map, where I cannot find a median() function. Any ideas?
You can compute the median easily using the following modeling algorithm:
Another way you can find the median is by doing a Profile on the household income column (provided that you have converted the column to its correct datatype, that is, integer or float).
Alternatively, you can simply sort the table by the column, and jump to the middle row.


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Best, Netherlands
Member since2003
The member has not specified any exchange dates
Nice house in Best, Netherlands (near Eindhoven)
We are Paul (58) and Mabel (53). Our sons Guido (16) and Jarno (15) and our daughter Jorieke (13).
There is much to see and do here, as well as in the surrounding area, it takes one and a half hour to Amsterdam, one hour to Antwerp
Our Family
- 2 Adults
- 3 Children
- 13 Exchanges made
- information analist
- teacher
Our Home
- House Type: House
- Floor: 0
- Environment: In the suburbs
- Bedrooms: 4
- Bathrooms: 1
- Sleeping Capacity: 6
- Living Area: 45 m2
- Total Area: 150 m2
In my house
- Pets - Not allowed
- Small children - Allowed
Exchange Types
- Bed & Breakfast
- Hospitality wanted
- Home exchange
- Free internet access
- Computer available
- Central heating
- Fireplace
- Toys and games
- Washing machine
- Dishwasher
- Clothes dryer
- Television
- Garden
- Park / playground
- Bicycles: 5
- No smoking
- Use/Exchange of car
- Pet care wanted
Our Destination Wish List
- Open for all offers
- Vancouver, BC, Canada
- Austria
- Switzerland
- Germany
- Denmark
- Spain
- Finland
- France
- Great Britain
- Ireland
- Iceland
- Italy
- Luxembourg
- Netherlands
- Norway
- Portugal
- Sweden
- Europe
- Belgium
Spoken Languages
- English
- Dutch
Our Neighbourhood
Best is very friendly for children. At the back of our home is a big playground, which continues all over our neighbourhood.
Special bikinglanes through Best makes it safe for children to practice biking and skating.
Within 20 kilometres there are two Zoo's: Dierenrijk, with a lot of playgrounds and de Beekse Bergen, where animals heve got very big areas to live. With your own car or by buss you can go through the area where giraffes live. At the Beekse Bergen is also a beach/playpark.
In Best we've got "Dippie Doe". A very big playground in the open air and in big halls.
When you love to swim, you can do so in the open air in Best, but also next to Dippie Doe at AquaBest.
When you love to visit old citys, whe've got Oirschot and 'sHertogenbosch nearby. Amsterdam takes about 1 hour drive by car. Antwerp less than an hour.
- information analist
- teacher
- Boy - Age: 18
- Boy - Age: 17
- Girl - Age: 14
- 2 cats
About Our Family
Paul works at DAF as coördinator logistics systems. He likes to motorcycle and swim.
Mabel works as a teacher in a secondary school. She teaches arts. She loves to create objects of clay and to draw.
Guido is our oldest son. He's sixteen years old and fond of music and reading books, he plays drums and he loves swimming.
Jarno is our second son. He is fifteen years old. He also loves to swim and play guitar and drumms. He loves to play games as monopoly, Piranha panic or kimble, so we've got a lot of games in our house. Also he is the mechanic in the house (with a little help of his father).
Jorieke is thirteen years old. She likes to sing and dance and cycling around in the neighbourhood.
We've changed houses for twelve times now and went to Canada (twice), Sweden (thrice), Belgium, Spain, France, Ireland, Germany and Holland. We all loved the sensation of living in an other country.
Tibbe and Twiggy are our two cats.
This member has completed 13 successful exchanges. Here are some members that he exchanged with in the past:


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Dr. Robin Kent
Related Suppliers
In April, we discussed the use of the slope of the curve of process energy consumption versus production volume for internal benchmarking of energy efficiency. That curve is called the Performance Characteristic Line (PCL) and the term "internal benchmarking" refers to comparing present performance to a historical standard.
Despite the usefulness of the PCL for internal assessment, it does not by itself allow for the external benchmarking that is necessary to drive significant improvements in performance. External benchmarking is when you compare your plant's performance to that of your peers or competitors. If you are an injection molder, can you afford not to know how you compare with other molders?
Featured Content
Benchmarking is difficult for two reasons:
- Energy use in plastics processing varies with the type of process (as explained in previous columns) and each type of process thus requires a specific external benchmarking reference.
- Energy use in any process varies with the production rate but also incorporates the fixed or base loads associated with plant services and the high fixed loads found in most plastics processing machinery.
For all materials conversion processes (not just plastics processing), it is possible to set up a model system for either a plant or a machine, where the total electrical load (in kw) consists of a fixed base load (the services) plus a process load that is directly proportional to the production rate in lb or kg per hour. The total load for this type of system is shown in Fig. 1.
The conventional measure of process energy use is the Specific Energy Consumption (SEC), which is expressed as the number of kwh used to process 1 kg or lb of material (kwh/kg or kwh/lb). The SEC for this model system can be calculated for various production rates, as is shown in Fig. 2 along with a hypothetical average of SEC results collected from different plants or machines. It is obvious that the average plant or machine SEC is not representative of the model system and that any attempt to benchmark a plastics processing method must include the production rate to produce meaningful results.
This is because the fixed loads remain effectively constant whatever the production rate and must be amortized over the actual production volume. At low production rates, the actual process load is low and the fixed load of the plant and machine dominates the total energy use. Thus the effective SEC of the process will appear high. At high production volumes, the actual process load is high and the fixed loads decrease in importance, so the effective SEC of the process can appear much lower. This is a simple amortization of the fixed loads into the variable process load, and it has two important effects:
Comparing sites or machines is meaningless unless the base loads and the production rates are taken into account.
There is no conflict of interest between being "green" and being profitable. Running plants and machines harder increases the energy efficiency of the process because base loads are amortized over higher process loads at the higher production rates.
An operating curve for SEC (kwh/kg) versus production rate for injection molding has been generated from 98 injection molding plants throughout the world and the data has been fitted with a power-law "line of best fit" to produce the operating curve shown in Fig. 3.
This operating curve corrects the predicted SEC for variations in production rate, so it is now possible for an injection molding site to benchmark itself against other similar sites. This can be done by:
- Calculating your plant production rate (in kg/hr/machine).
- Finding the predicted plant SEC from Fig. 3 at your plant's production rate.
- Calculating your actual plant SEC from the total electricity use (kwh) ÷ total material processed (kg or lb).
- Comparing your actual plant SEC at that production rate with the SEC benchmark.
Individual sites can now carry out this simple process to determine their ranking relative to the average performance of the 98 sample sites around the world. Keep in mind that achieving the benchmark SEC is not a sign of good or best practice, only a sign of average practice.
As with plants, it is also possible to benchmark individual machines, and the effect of the specific production rate is very similar. An operating curve for machine SEC versus production rate for injection molding has been generated from 141 hydraulic injection machines and tool combinations and the data has been fitted with a power-law line of best fit to produce the operating curve shown in Fig. 4.
This operating curve corrects the predicted SEC for variations in production rate and it is now possible for an injection molding plant to benchmark its individual machine and tool combinations against other typical machine/tool combinations. This can be done by:
- Calculating the average machine production rate in kg or lb per hr.
- Finding the predicted machine SEC from Fig. 4 at the specific production rate.
- Calculating the actual machine SEC from the total electricity use (kwh) ÷ total material processed (kg or lb).
- Comparing the actual machine SEC at that production rate with the machine SEC benchmark.
Plants can now benchmark their machine/tool energy performance relative to the performance of 141 sample machine/tool combinations—but achieving the benchmark SEC is, again, not a sign of good or best practice, only a sign of average practice.
About the Author
Dr Robin Kent is founder and managing director of Tangram Technology Ltd. in Hitchin, Herts., U.K. Tangram provides consulting engineering, training, and design services to plastics processors. Kent has been involved in injection molding and extrusion for 36 years and has worked as technical director for several major plastics processing companies in the U.K. and Europe. He can be reached at email@example.com or visit www.tangram.co.uk. Articles in this series are adapted from his book, Energy Management in Plastics Processing (2008, 265 pages, www.pidbooks.com).
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All About 'Cushion'
What it means. Why it's important.
How to Reduce Sinks
Modifications to the common core pin can be a simple solution, but don't expect all resins to behave the same. Gas assist is also worth a try.


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I have been a nail biter for as long as I can remember. Some say it is a nasty habit? I have never understood why.
They say it is because it can make you sick to put your fingers in your mouth. . . sounds like a stronger immune system to me.
They say it can cause you pain and bleeding if you bite your nails to far. . . So don't bite so far next time?
They say it can give you hang nails or infections . . . Well, just be careful!
I honestly have had no problems with biting my nails. I actually really enjoyed doing it. It was something I actually looked forward to doing. It was a stress reliever for me, especially during really intense scenes in a movie.
Yes, I can hear you saying, "GROSS and EW!" But guess what? It doesn't phase me, because I have heard that for YEARS and it has NEVER STOPPED ME . . . until now.
Well, while I was in Costa Rica, look what happened . . .
I grew my nails. And it was completely by accident too. I just happened to look down one day and saw these amazingly long and STRONG nails on my hand. I instantly tried to see if I could bite one, but I couldn't. It was too thick. I have NEVER had nails this thick or long before in my life!
I checked Paul's nails and he too had long nails and his were strong like mine. He was excited to discover how strong his nails were as well. Because his nails are usually super weak and tear easily. We couldn't imagaine what Costa Rica offered that Utah didn't, in growing strong nails without trying. Was it the ocean water? Was it the milk we drank? Was it the lack of processed food and chemicals in our diets?
Who knows? But after having had these nails for a few weeks, I decided it was time to give growing my nails out a try.
At first I was going to treat myself to a manicure and "watch" how they do it, so I could do it myself. But I am far too tired and too cheap to do that right now. Then the idea came to me to research how to do it on the web.
I found dozens of "DYI manicures" on YouTube. It was great! Now I not only have strong, long and shiny nails, but my nails are filed and don't snag on things anymore.
So, what do you think? Should I give it a try or just bite them off?


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We're into September—well past the halfway point of 2014. We'll soon be starting the fourth quarter of the year and if you're like most salespeople, the summer heat might have you dragging a bit. Well, today I wanted to share 20 Great Sales Motivational Quotes. A few years ago I posted My Favorite Motivational Quotes and recently had My Favorite Maya Angelou Quotes after her death.
But today I want to focus mainly on sales.
20 Great Sales Motivational Quotes
Enjoy. Oh, and add some in the comments if you have a favorite I left out!
"You don't earn loyalty in a day. You earn loyalty day-by-day." ~ Jeffrey Gitomer
"Your true worth is determined by how much more you give in value than you take in payment." ~ Bob Burg
"The most unprofitable item ever manufactured is an excuse." ~ John Mason
"You don't close a sale; you open a relationship if you want to build a long-term, successful enterprise." ~ Patricia Fripp
"Your only limitations are those you set up in your mind, or permit others to set up for you." ~ Og Mandino
"Selling is the easiest job in the world if you work it hard—but the hardest job in the world if you try to work it easy." ~ Frank Bettger
"The man who does more than he is paid for will soon be paid for more than he does." ~ Napoleon Hill
"I am not judged by the number of times I fail, but by the number of times I succeed and the number of times I succeed is in direct porption to the number of times I can fail and keep trying." ~ Tom Hopkins
"You can have everything in life that you want if you just give enough other people what they want." ~ Zig Ziglar
"Your number-one job is to tell your story to the consumer wherever they are, and preferably at the moment they are deciding to make a purchase." ~ Gary Vaynerchuk
"Average achievers believe that learning ends after high school and college; top achievers believe that's when it starts." ~ Andrea Waltz
"If you don't design your own life plan, chances are you'll fall into someone else's plan. And guess what they have planned for you? Not much." ~ Jim Rohn
"The world doesn't need more people playing small. It's time to stop hiding out and start stepping out. It's time to stop needing and start leading. It's time to start sharing your gifts instead of hoarding them or pretending they don't exist. It's time you started playing the game of life in a 'big' way." ~ T. Harv Eker
"Be careful the environment you choose for it will shape you; be careful the friends you choose for you will become like them." ~ W. Clement Stone
"Pretend that every single person you meet has a sign around his or her neck that says, "Make me feel important." Not only will you succeed in sales, you will succeed in life." ~ Mary Kay Ash
"A dream is just a dream. A goal is a dream with a plan and a deadline." ~ Harvey Mackay
"Nobody counts the number of ads you run; they just remember the impression you make." ~ William Bernbach
"Every sale has five basic obstacles: no need, no money, no hurry, no desire, no trust." ~ Zig Ziglar
"There's no lotion or potion that will make sales faster and easier for you – unless your potion is hard work." – Jeffrey Gitomer
"A mediocre idea that generates enthusiasm will go further than a great idea that inspires no one." ~ Mary Kay Ash


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Take a look at the screenshots to see the program in action before downloading and trying it for yourself!
- exists for several platforms
- supports pressure sensitive graphics tablets
- extensive brush creation and configuration options
- unlimited canvas (you never have to resize)
- basic layer support
MyPaint comes with a large brush collection including charcoal and ink to emulate real media, but the highly configurable brush engine allows you to experiment with your own brushes and with not-quite-natural painting. Before beginning it is a good idea to read the quick-start tutorial to see how the program is meant to be used. You can also visit the MyPaint Wiki.
Bug reports and feedback are welcome. You might also want to check out what is under Development.
Related projects are DrawPile, Flowpaint, Qaquarelle, Gogh, Alchemy, Krita, ChibiPaint, Harmony. You might like easystroke for defining gestures.
Go there...


text: In 2010, Gray Line brought a new franchisee. Gray Line Cruise Halong – the first overnight cruise of Gray Line World Wide in Vietnam. Complimentary to Gray Line's own set of core values; Gray Line Cruise Halong's motto embodies a commitment to treating each visitor as a friend and local. It goes without saying that every product is fine-tuned to provide experiences. Whether they pertain to culture, adventure or the unique cuisine, that are true to the Vietnamese way of life.


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Indoor plumbing didn't come about until the early 1800s, when it was first introduced in a hotel. It wasn't until the mid-1800s that the middle and lower class had the opportunity to use indoor plumbing, since prior to the 1840s, indoor plumbing was only for the rich and for businesses. With the introduction of plumbing, especially indoor plumbing, there became a need for individuals trained in plumbing repair.
If you're wondering whether your issue requires the service of a trained professional, here are some repairs that plumbers commonly handle.
1. Leaking pipes
A plumber deals with all types of leaking pipes found in your home, including pipes that carry waste to your water pipes that are attached to your shower. Some issues with leaking pipes are easy to fix on your own by simply tightening a valve by using a wrench, while others may require you to replace a portion of the piping.
2. Clogs
Contrary to fixing pipes that are leaking is dealing with the issue of clogs, and plumbers handle that as well. So if you're child stuck her toy doll down the toilet, or if you're pipes are backing up due to hair accumulating within them or even oil, a plumber can fix that!
3. Toilets and other fixtures
A plumber doesn't just handle the water pipes or the line running to your home, he also deals with the toilets and sinks, whether they require a simple fix like replacing a part, or they need replaced completely.
4. Bathtub and shower installation
If you decide you want to switch from a traditional bathtub that includes a shower head connected from the wall to a standup shower without a tub, you should contract a plumber. A plumber does installation of showers and tubs, both of which are a long and complicated process to do on your own.
5. Water heater installation and repair
Your water heater is your connection to taking a shower and washing your dishes. It's easy to take for granted hot, running water, especially on those cold winter days, when a hot shower really warms you up. If you start to experience problems with your hot water, you should contact a plumber. He can identify the issue and fix it, since repairing a water heater should not be a DIY-project for those unfamiliar with hot water tanks. Additionally, the installation process requires someone to solder the pipes. This process is a delicate one, due to the fact that it's very easy to do damage to your tank, which probably cost you hundreds of dollars.
6. Installing pipes
A plumber can install or reroute your water pipes, both in your home and underneath your home.
7. Emergency projects
If an entire pipe bursts and your home is flooding, a plumber can tend to that. Many contractors and plumbing companies are staffed for 24-hour assistance for emergencies.


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|History and stories about Padaun
In Padaun there are several important farms. Beside the Steckholzer there also should be named the Pflerscher and Larcher farm.
Beside the farms, also some farms of the valley have an alp in Padaun. These are the Kolb, Steinbock and Moor alp.
Additionally some children of the farmers built there their homes and houses, as also some vacation huts have been constructed.
Balbine Bacher the owner of the Pflerscherhof in the past always contributed and collected the cultural values of Padaun.


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Looks like Google broke the seal today on the Google Wave Frame project. Google has released Google Wave Frame for Internet Explorer, which brings the Chrome browser to Explorer 6/7/8. Basically, users can use Wave Frame plugin to run Chrome inside Internet Explorer.
As a marketer (or a developer), you better start thinking about the impact that this will have on your analytics. It is actually one of the easiest way to identify and segment your early technology adopters from your standard visitors. To identify these users, you can leverage the user agent string. Visitors with Google Wave Frame will generate the standard user agent string for Internet Explorer except that you'll see an the addition of the word chromeframe.
Now granted, adoption for Google Wave Frame is not going to skyrocket overnight so don't expect a flood of Wave Frame visitors. Considering the impact of Google Chrome (last time I checked with some of our clients at Engauge, Chrome adoption is barely scratching the surface), it will take a while before it will crack the top 6 browser used on your website ceiling. Nonetheless, start paying attention to your analytics report because web analytics tools will likely get this one wrong for the next few weeks.


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3 Mar, 2016 – If you are in search of a website that helps you read different kinds of Manga series comics online for free then make sure that you visit the website of Hey Manga as it has the complete collection of manga comic series in different categories. The reader series of Manga has earned global popularity that has made people of ages love it and await the latest ones in different series. If you wish to spend your free time reading some interesting stories then Manga series that are developed by professional illustrators, is a great choice. These Japanese comics are offered with eye grabbing drawings and unique storyline that makes it a favourite of all.
These days many sites provide Manga stories in various genres but it is important for you to choose the best site to read these stories. The site at http://www.heymanga.xyz is a perfect destination for reading your Manga stories as it has impressive illustrated comic series translated in simple English that makes it easy to read. You will fall in love with this manga site as it has a huge selection of comics to satiate your reading requirements such as mystery, gender bender, romance, action, mature, adult, comedy, adventure, fantasy, martial arts etc. when you click on the site of Hey Manga to read manga you will find different categories such as latest manga, random manga, manga series, manga genre and history option for your convenience. There is also a search feature that lets you search for a specific manga story instead browsing along the pages in search of it.
When you click on the random manga category on the Hey Manga site, it would give you a list of random stories of varied genres. And you can choose the Manga genre category to find several categories listed there and chose any genere of your choice. The latest manga category would give the full list of latest manga stories updated every day along with the details of the time it was updated last. The history option in this site helps you to get access to the list of stories you read on this site previously to help you know which ones you preferred the most. When you click on the category named, Manga series you will find hundreds of stories listed on the site in A to Z order. Each story is available with a drop down list consisting of page numbers and chapter number to help you choose that specific chapter or jump to a page number right away without having to pass across every page.
About Hey Manga:
The best thing about the site of Hey Manga is that it has an amazing collection of Manga stories to make your every visit a worthier and memorable one. When click on a story on this site it provides you an experience of reading 4 to 5 pages of a book at one glance with neat translations and pictures.
Media Contact
Company Name: Hey Manga
Contact Person: Joseph S. Fletcher
Email: email@example.com
Phone: 708-628-2413
Address:2616 Star Route
City: Wheeling
State: IL
Country: United States
Website: http://www.heymanga.xyz


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This year the travel bug bit us hard, and our family road trip was the longest, hardest trip to date with kids. Whether by luck or design, we have quite the list of destinations that we have hit already this year or will be traveling to. Some are sans-kiddos, like our parents weekend in Las Vegas or the upcoming visit to the Country Music Capital of the Southwest, Las Cruces. And there are some destinations that were truly a family affair, like our 15 hour haul in a super RV to the Ozarks!
Yes, we piled our family and extended family of 9 total people into a giant RV and hit the open road headed east towards Missouri. It really was a trip. Traveling with little kids is always a task, but there are some essentials that you need to include to make the trip fun.
Our trip was a huge success and I will be sharing more of the details that helped to make it so. This post is going to give you your survival guide. All the essentials that you need to have a smooth trip with little kids, no matter the distance.
- Snacks
You might be thinking, "duh, lady" but hear me out. Sure, a case of chocolate chip cookies is what they want, and because it is vacation you might want to oblige. You can include healthy snacks like fruit without sacrificing sacred space in your RV by taking Crunchies Freeze-Dried Grab-n-Go Mixed Fruit. I love these and so do the kids. You can pack fruit without it getting squished and going bad or taking up precious fridge or cabinet space. Kids enjoy little fistfuls of bananas and strawberries. Plus – you can use as a yogurt topper and you've just covered breakfast on day one of your trip! Crunchies come in Pack of 6 and might I add that Mango is delicious!
2. Coloring Book
Yes, it obvious that the kids need something to do on a long and grueling drive, but what about you, mama? While I typically love driving, especially long distance, there was no freakin' way I was going to drive the Tour Bus for our Mayhem Festival. Not. A. Chance. Which also meant that I needed something to do. Mama Survival. While I love a good Dora The Explora Activity Book as much as the next fool, I brought along something just for me. Be honest, when is the next time you'll actually have time to sit and color with your herd of children if not on a long RV trip. This is super essential. Better than a book which no one will let you read anyhow. (Plus, you might get car sick)
I adore this coloring book because it helps keep me mindful of all the things I love about being a mom with amazing quotes. Stephanie Corfee is a great artist as well and sent me this book before it hit the shelves, so I got my color on in advance! The kids liked coloring with me on the trip and it kept everyone quiet for, like 5 seconds!
3. Games
Board games are a travel & camping essential. There is no way to survive a rained in day or long road trip with out them. Now, while we usually keep our camper stocked with Cards Against Humanity and The game of Life what you need for a road trip is travel games!
We played Eye Spy, Eagle Eye at minimum 27 times. Even Madeline could play, which is great, because no one likes to be left out. Its a fun game without little pieces, which makes it chances of survival on a road trip so much better. We also like card games like Uno, Monopoly, and Go Fish. It's essential that everyone can play and when the rumbles are kept to a minimum, survival is guaranteed!
4. Amazon Prime & Kindle Fire
Try Amazon Prime 30-Day Free Trial
Are you sick of me swearing by Amazon Prime yet? Well, I'll never stop. We bought each Kidiot a Kindle Fire for Christmas last year knowing full well that they would be our biggest survival tool for this years multiple road trips. We might have screen time on lock down at home thanks to Amazon Free Time but we let them have unlimited time on our road trip. We stuck them in the back bedroom of the RV with their Kindles and a couple minutes into a downloaded movie, they were out! Score!
This is a short list of my essential for surviving a road trip with small kids. I will be posting an Ultimate RV Packing List soon so that you can get your Road Trip on this summer without forgetting any of the important shit, like tooth paste and butter. Swear those are the most commonly forgotten items!
Good luck on your road trip!


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Video Games Coupon Deals & Promo Codes
For those who love to order food in and spend your free time racing a car, building a new world, or tackling a mutated dragon from the sofa with some yummy and easy to eat snacks handy, video games can't be beat. Old classics like Pac Man and the newest releases (think Mindcraft and Mario) keep kids of all ages busy for hours on end. Just stay hydrated, and don't forget to stretch once in awhile! Save money on your video game needs, like consoles and controllers and the video games themselves, by shopping our video game picks below.
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You can literally get a subscription box for just about anything these days and one for all your shaving needs hasn't been left out. Friction Free Shaving have two razors on offer, Frankie & Samantha which both have different razor heads available, Frankie has the 3 blade heads with it which costs £5 per month and Samantha has 5 blade heads at £8 per month. It's a way to say goodbye to blunt blades because let's face it, I'm sure so many of us know just how that feels! There are 4 blades in each box, one for every week to help keep your legs in tip top condition. Their aim is to make shaving cheaper, easier and cleaner for us women to get our legs feeling silky smooth. Starting from £5 per month it couldn't be easier to keep on top of your blades where bacteria breeds! You would be surprised at how bad it can get " If someone shaved their legs everyday for a week (that's dedication right there), that would be the equivelent of shaving a tennis court. Pretty epic right? And a wee bit grim. Bacteria and all sorts of nasty stuff gets built up in those blades, so remember: "Change your blades once a week, and your legs shall be smooth & sleek." check us rhymin'!"
These boxes have free P&P and no hidden costs! It's perfect for us women who enjoy a good shave. You also get the choice of wither or not to add on their very own Shaving cream which moisturises your skin and leaves your legs feeling AMAZING! This add on cost's an extra £6 on top of the box price but you don't have to choose it if you don't want it, although I do recommend it as it made my legs feel amazing and it was really easy to apply. I will say that at first I was a little sceptical as it was just a cream, like rubbing lotion on my legs in the shower and it didn't lather which I wasn't keen on at first but after shaving my legs and getting out the shower my legs felt amazing!
About the Shower Cream
"Designed specifically for women and packed with moisturising Manuka honey, Shea butter and coconut oil, our shave cream gives your skin the treatment it deserves. Its unique 'cationic' formula reduces friction so you get a closer shave and smoother skin. The transparent application provides maximum visibility and offers a new sense of control and closeness."
For my box I chose Frankie as I love anything pink! I do however wish I chose Samantha as she looks super sleek and comes with 5 head blades.... silly me didn't even think twice when picking the pink one because, well, that's my favourite colour but in hindsight I would have picked Samantha. This being said though there's absolutely nothing wrong with Frankie, she has a good grip and the razor heads are pretty awesome to. I really love how weighted the handle is, it's one of my favourite things about this razor.
The heads on this are really easy to change, clip on well and come off with ease. The three head blades are fab, they do the job, leave me feeling smooth, no hair is left behind.
About Frankie
Hey chick, I'm Miss Dependable - you can always count on me. I've got three ceramic coated blades for an extra smooooth glide and a vitamin E strip to moisturise your skin. My wide soft rubber guard helps lift your hairs up, then my full 90 degree pivot head slices the little guys off. I know we're going to get along - BFFFF's? (that's Best Friction Free Friends Forever, BTW)!
- 4 made-in-America razor refills per month
- 3 stainless steel razor blades per head
- Ceramic coated blades provide an extra smooth glide
- Vitamin E lubricating strip moisturises the skin
- Full 90-degree pivot head contours the body form
- Heavy weight feel gives amazing control


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开始时间: 待定 持续时间: Unknown
所在平台: Coursera
课程类别: 物理
大学或机构: University of Maryland, College Park(马里兰大学学院园分校)
课程主页: https://www.coursera.org/course/eqpExplore 1600+ online courses from top universities. Join Coursera today to learn data science, programming, business strategy, and more.
Quantum physics is the foundation for much of modern technology, provides the framework for understanding light and matter from the subatomic to macroscopic domains, and makes possible the most precise measurements ever made. More than just a theory, it offers a way of looking at the world that grows richer with experience and practice. Our course will provide some of that practice and teach you "tricks of the trade" (not found in textbooks) that will enable you to solve quantum-mechanical problems yourself and understand the subject at a deeper level.
The basic principles of quantum physics are actually quite simple, but they lead to astonishing outcomes. Two examples that we will look at from various perspectives are the prediction of the laser by Albert Einstein in 1917 and the prediction of antimatter by Paul Dirac in 1928. Both of these predictions came from very simple arguments in quantum theory, and led to results that transformed science and society. Another familiar phenomenon, magnetism, had been known since antiquity, but only with the advent of quantum physics was it understood how magnets worked, to a degree that made possible the discovery in the 1980's of ultrastrong rare-earth magnets. However, lasers, antimatter and magnets are areas of vibrant research, and they are all encountered in the new field of ultracold atomic physics that will provide much of the material of "Exploring Quantum Physics".
Richard Feynman once said, "I think I can safely say that nobody understands quantum mechanics." We say, that's no reason not to try! What Feynman was referring to are some of the "spooky" phenomena like quantum entanglement, which are incomprehensible from the standpoint of classical physics. Even though they have been thoroughly tested by experiment, and are even being exploited for applications such as cryptography and logic processing, they still seem so counterintuitive that they give rise to extraordinary ideas such as the many-world theory. Quantum physics combines a spectacular record of discovery and predictive success, with foundational perplexities so severe that even Albert Einstein came to believe that it was wrong. This is what makes it such an exciting area of science!
Week 1 (March 25 -31)
Lecture 1: Introduction to quantum mechanics. Early experiments
An introduction to quantum physics with emphasis on topics at the frontiers of research, and developing understanding through exercise.
Maps and the Geospatial Revolution 关注
Analytical Chemistry / Instrumental Analysis 关注
Introduction to Thermodynamics: Transferring Energy from Here to There 关注
Synapses, Neurons and Brains 关注
Science from Superheroes to Global Warming 关注


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AFL 2018 International Broadcast Scheule - Round 2
Wednesday, March 28 2018 @ 02:50 pm ACDT
Contributed by: Troy Thompson
Views: 1,555
Round 2 of the 2018 AFL Season kicks off tomorrow (Adelaide time) at the Adelaide Oval with reigning the Adelaide Crows hosting Richmond.
The full international broadcast schedule can be seen below.
In addition to the TV networks you can also subscribe to the Watch AFL service that will give you live access to all the matches and more (outside Australia only).
You can access that service by clicking on the link here or the Watch AFL promo shot on the left to register and by then paying the subscription fee.


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- This event has passed.
Special Offer – Neds Blue Diamond Stakes Day Tickets
February 1 @ 8:00 am - February 21 @ 11:59 pm
Reward yourself
Love your racing or even just a good deal?
Hopefully you've earned loads of bonus points in our Double Double promotion last month, now's the time to make them work for you.
Redeem two general admission tickets for Neds Blue Diamond Stakes Day for 3,000 Points.
Hurry – this special offer is only available until Friday 21 February.
Remember, redeeming your points does NOT affect your tier status and bonus points earned through promotions do NOT add to tier status so make the most of them with these special offers.
Terms & Conditions apply


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Look at all these celebrities in St. Paul!
Where can you find Billy Crystal, Ray Lewis, Portia Clark, Bill Clinton, Evander Holyfield, Frankie Muniz, Sinbad, Forest Whitaker, Gloria Gaynor, Alice Cooper, and America's Got Talent champ Darci Lynne Farmer in the same place? At the Starkey Hearing Foundation's annual "So the World May Hear" awards gala, of course! Hamilton mastermind Lin-Manuel Miranda even popped in via video screen. Here's a look at the July 15 festivities inside the St. Paul RiverCentre. All photos by Steve Cohen.


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Y&R's 'McWhopper' for Burger King Adds Another Cannes Grand Prix, in Media
Tasty idea from the burger giant
CANNES, France—After winning a Grand Prix in Print & Publishing at the Cannes Lions festival earlier this week, Y&R New Zealand won another Grand Prix tonight, this time in the Media category, for its Burger King "McWhopper" campaign.
The idea was simple, but brilliant.
Last August, the brand came up with a clever idea to hopefully band together with one of its greatest competitors—McDonald's—on Peace Day. BK bought a full-page ad in The New York Times and the Chicago Tribune (the city where the McDonald's headquarters is located), publishing an open letter of sorts to McDonald's, asking the brand to collaborate on a limited product, the "McWhopper," to be sold one day only.
BK proposed that the chains meet in Atlanta, halfway between McDonald's headquarters in Chicago and Burger King's headquarters in Miami, and create a pop-up shop to sell the Burger King-McDonald's creation. All proceeds would go to Peace One Day, a non-profit organization dedicating to spreading peace.
McDonald's CEO Steve Easterbrook vetoed the idea, suggesting the brands team up at a later date to create a "meaningful global effort," but BK had already gained a huge amount of media attention for its work. The idea inspired other burger chains to reach out with the hopes of raising awareness for Peace Day on Sept. 21. Denny's, Wayback Burger, Krystal and Giraffas all threw their names in the ring for a Peace Day partnership, responding to BK's initial letter on Twitter.
The success of the campaign can't be denied, and the jury couldn't resist handing the "McWhopper" another Grand Prix.
"I think our Grand Prix reflects so much of what it good about the industry," said jury president Nick Waters, CEO of Dentsu Aegis Network Asia Pacific. "This is a case of a big brand. And big brands sometimes find it difficult to move quickly. This is a case of a big brand taking on an even bigger competitor, moving quickly, being bold, acting within the brand, acting cheekily, reacting to events, bringing consumers in," he added.
Waters noted that the "McWhopper" campaign was the perfect Grand Prix choice for the Media category, stating that "none of this could have happened without a brilliant use of media. It would not have created such amazing momentum, such a storm, without a brilliant use of media."
Code & Theory, Alison Brod Public Relations, The David Agency, Rock Orange, Turner Duckworth and Horizon all contributed to the campaign as well, alongside Y&R New Zealand.
—U.S. Media Lion winners
U.S. agencies took home a number of Lions in the Media category this year—no golds, but eight silvers and nine bronzes.
Leo Burnett Chicago scored two silvers for its Van Gogh-inspired Airbnb rental for The Art Institute of Chicago. Starcom Mediavest Group Chicago won a silver for its Airbnb "No Borders" campaign, while FCB Chicago won silver for "The Baby Stroller Test-Ride" for Contours Strollers. VML New York's "Legoland Dollars" campaign for the Legoland Florida Resort scored silver as well. J. Walter Thompson New York's Tribeca Film Festival Reactor won a silver, while Grey New York won silver for the "Gun Crazy" campaign for States United to Prevent Gun Violence. R/GA Hustle L.A. also won a silver and bronze for "Straight Outta" for Beats by Dre.
Other bronze winners include Deutsch L.A.'s first live music video with Gwen Stefani for Target; David Miami for the Burger King "Whopper Sign" work; McCann New York for "The Field Trip To Mars" campaign for Lockheed Martin; OMD New York for Intel's Winter X Games 2016 work; and CP+B Boulder for "Captain Obvious Runs for President" for Hotels.com.
Grey New York won three Bronze Lions in Media: one for "Gun Crazy," one for Canon U.S.A.'s "Unknowns" and one for the Volvo "Highway Robbery" campaign.


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I have been doing a lot of thinking lately about my business: how far I've come, where I'm going, what I'd like to achieve.
But, mostly, I have been reviewing what I've learnt.
Just to recap - this year I started selling my crafts on Folksy and Wow Thank You. I participated in 2 on-line Craftfest fairs and 2 real life craft fairs. I now have a facebook page, a Twitter account and a few other social media accounts.
So I have learnt quite a lot of techie stuff...
.... I have learnt how to set up RSS feeds so that when I post on Folksy or WTY, a post automatically appears on my FB page....
.... and I have learnt how to schedule Tweets and FB posts so that they appear when I want them (and not all at once)....
.... and I am beginning to get the point of Twitter although I am still not sure if I will ever find it particularly useful as a marketing tool.
These lessons have been useful but they are overshadowed by some of the things that I have learnt about selling and about myself. These things are what I would like to focus on today.
So here's what I have learnt this year:
- People value what I value - I have no reason to apologise for the price of items that take a great investment of time and love. The price I ask is fair and reflects the value I place on my skill and time.
- People who cannot value what I make are not worth my worry - even if I were to sell my craft items at a price that just covered the cost of materials, I would still be undercut by poorly made imports. If that's what people want then they will settle for the cheap alternative, but I will not stoop that low.
- Giving something away can be as satisfying as selling it - whether as a gift to a special friend or as a prize in a competition - knowing that what you have created has gone to a good home is always a special feeling.
- Parting with an object made with love can be hard - this is especially true with the bears: I find that I develop a strong attachment to each little character and it becomes very difficult to part with them. Benny has become part of the family and will now only be used for promotional purposes. Another reason why valuing your wares correctly is crucial: selling them for less than they are worth is soul-destroying.
- Consistent marketing produces results - I know, I know, I shouldn't have needed a year to work this one out but sometimes I cannot be told! When I consistently listed new items, blogged, tweeted and posted, I made sales; when I stopped listing, blogging, tweeting and posting I made no sales! Surprise, surprise!
- Selling is hard - it's hard to find your customers, it's hard to convince them they need what you are selling, it's hard not to become discouraged. But no-one ever said it would be easy, did they?
- Love what you do - if you create with love, describe with love, package with love and sell with love your customer will also love what you do. What could be better than that?
- Make things for me - sometimes I just want to make something for the sake of it. Just for me. And that's OK.
- Make someone smile - sometimes it is enough that my bears make someone smile. The chance to brighten someone's day is a precious gift and a worthy goal.
- My time is limited - There is only so much time to make things and to develop new ranges. This year I have floundered a little and lost the path. As my OH pointed out recently "Bears are supposed to be your thing... so list some bears!"
Some of these lessons have been harder to learn than others. Some I seemed determined to struggle with even when I could have learnt them quickly from other people. I am sure that there will be new challenges to face in the year ahead but they will not seem so daunting if I can remember how far I have already come.
What lessons have you learnt this year? I'd love to hear about them!


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Thank you for your interest in joining the NYC Children's Theater family!
Here are some of the many ways you can become part of our community, whether you want to help us bring quality theater to kids and adults in the greater New York City area, or just attend a show. Click on any of the items below to learn more:


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Values & pillars
It is our conviction that the Spirit of God has asked us to make this love concrete in the world, incarnate in our thoughts, our bodies, our lives and our every action. Beautiful Feet exists to participate in bringing the Kingdom of God to earth in all its aspects, but most especially through our particular calling to serve "THE LEAST OF THESE": the poor, the destitute, the lost, the broken and the forgotten.
Our Values and Pillars direct us as we seek to love others. It's how we walk with Beautiful Feet every day.
Our Values
"Dear children, let us not love with words or speech but with actions and in truth" 1 John 3:18
"Our mouths were filled with laughter, our tongues with songs of joy. Then it was said among the nations, 'The LORD has done great things for them'" Psalm 126:2
"Therefore we do not lose heart. Though outwardly we are wasting away, yet inwardly we are being renewed day by day… So we fix our eyes not on what is seen, but on what is unseen, since what is seen is temporary, but what is unseen is eternal" 2 Cor. 4:16 &18
"The Purposes of a person's heart are deep waters, but one who has insight draws them out" Proverbs 20:5
"If anyone speaks, they should do so as one who speaks the very words of God. If anyone serves, they should do so with the strength God provides, so that in all things God may be praised through Jesus Christ. To him be the glory and the power for ever and ever" 1 Peter 4:11
"Now to him who is able to do immeasurably more than all we ask or imagine, according to his power that is at work within us" Ephesians 3:20
"And let us consider how we may spur one another on toward love and good deeds…" Hebrews 10:24
New wine must be poured into new wineskins Luke 5:38
"We have this hope as an anchor for the soul…" Hebrews 6:19


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A suicide car bomb blasted through two homes in Afghanistan Friday morning killing five people and wounding 15 others, authorities said.
The Taliban claimed responsibility for the attack in Kapisa province, saying the terror organization was trying to target U.S. troops, said Mehrabuddin Safi, the governor of the eastern province.
No troops were killed or wounded, only civilians, Safi said.FULL STORY
All Arab Nations should unite and and form a union to get intruders and converters out of the political arena of Middle East unfortunately Israel will not join as it is destined to collapse from within


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Graduate Teaching Assistantships for qualified students, when available, are awarded based primarily on previous academic record, seriousness of purpose in pursuing a degree, and competence in French. Teaching Assistantships offer the pedagogical experience and training necessary to be competitive on today's job market.
All Graduate Teaching Assistants enrolled in the MA or the doctoral program (as well as other MA or doctoral candidates, on a voluntary basis), regardless of track, benefit from supervised in-service pedagogical training with a language acquisition specialist. The training includes a required course on foreign language teaching theories and methods (FR 512), an optional course such as teaching culture or language teaching with technology, and several professional development workshops on assessments, teaching writing or reading, all aiming at developing teaching and presentational practices particularly valuable for future career placement.


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Preparation Directions
STEP ONEHEAT oven to 350°F. Spray an 8x8-inch pan with no-stick cooking spray.
STEP TWOCOMBINE shortening and milk in large microwave-safe bowl. Microwave on MEDIUM for 1 minute. Stir. Repeat until melted, stirring after each minute. Stir in sugar, then egg.
STEP THREECOMBINE flour, baking powder and salt in medium bowl. Stir into sugar mixture until blended. Stir in butterscotch chips, nuts and vanilla. Spread into prepared pan.
STEP FOURBAKE 27 to 30 minutes or until toothpick inserted in center comes out clean. Cool in pan on cooling rack. Cut into 2x2-inch squares.
We're Pie People
If you like pie as much as we do, you're gonna wanna check this out.
Butter Flavor, Crisco Results
For those who love the taste of butter, but demand the performance of shortening.


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Welcome! You can't pick up a newspaper or magazine or turn on the TV or radio without getting a constant onslaught of bad news about the economy. But there's good news related to this: Many experts predict that we Boomers are going to be the force that brings us out of the economic mess we're in right now… There Are a Number of Reasons For This: A greater percentage of us still have jobs: According to recent New York Times and Bureau of Labor Statistics numbers, by far the largest group of unemployed is the 15-to-24 cohort at a whopping 16.7% (in July this number soared to... (Read More ...)
Breast Cancer: No One Chose This Journey Author: Fran Padgett http://franpadgett.com Reviewed by: Anne Holmes for the NABBW This beautiful book, a compilation of 30 poignant breast cancer survivor stories visually supported by author Fran Padgett's stunning, original works of art, is her tribute to all women who have been "chosen by breast cancer," as she herself has been. After her diagnosis, Padgett launched a passionate mission to fund breast cancer research projects. She established The Weathervane Foundation, Inc., a Texas 501 (c) (3) – a non-profit organization dedicated... (Read More ...)
Your High Risk Pregnancy: A Practical and Supportive Guide Author: Diana M. Raab, MFA, RN with Errol Norwitz, MD http://dianaraab.com/nonfiction.html Reviewed by: Anne Holmes for the NABBW When the core of this book was originally released in 1987 (under the title, "Getting Pregnant and Staying Pregnant: A Guide to High‐Risk Pregnancies") it was a pioneering title. I know, because I'd actually searched for a book of this type ten years earlier during my first of two high-risk pregnancies, and had it existed, my old copy would be dog-eared, sticky-noted and full of underlining... (Read More ...)
You Lost Your Marriage Not Your Life: How to Create the Life You Want – Your Way Author: Barbara Miller http://www.youlostyourmarriage.com Reviewed by: Anne Holmes for the NABBW Al and Tipper Gore are not the first Baby Boomers to divorce after a long marriage, and they will no doubt not be the last. A recent AARP story, written after their announcement, noted several reasons Boomers are divorcing with more frequency then our parents. One of the most significant reasons, of course, is that we are living longer, and we aren't like our parents and grandparents who chose to soldier on, even... (Read More ...)
Changing Shoes: Getting Older – Not Old – with Style, Humor and Grace Author: Tina Sloan http://www.changingshoes.com Reviewed by: Anne Holmes for NABBW While many women hide signs of aging with tight clothes, heavy makeup and plastic surgery, 67-year old Guiding Light legend Tina Sloan learned to welcome each phase of her life with effortless grace — all while living a very public life. In the book Tina recalls how she made her first appearance on soap operas in the 1970s as the sex kitten on Somerset, and hit it big when she was cast as nurse Lillian Raines on Guiding Light, a role... (Read More ...)
Savvy, Sassy and Bold After 50! A Midlife Rebirth Author: Vicki Ward www.seasonedsistahs.com Reviewed by: Anne Holmes for NABBW This book is a handbook for living vibrantly after 50. It's an excellent resource, for women, by women. And it validates the experiences of those of us who have crossed the timeline into the second half of life. But it's more than that, as it is peppered with quotes from women who took the Sistah Survey, which according to author Vicki Ward, was developed to reveal the essence of what it's like to be a woman in the esteemed "Over 50 Club." While... (Read More ...)
Lost Angel Walkabout: One Traveler's Tales Linda Ballou http://www.LindaBallouAuthor.com Reviewed by: Anne Holmes for the NABBW This is a spirited collection of travel narratives, a beautifully written collection of personal experiences of Linda's many travels to different continents and environments. It is easy to see why Linda Ballou is a well-known adventure travel writer, each of the stories takes you to a special place and allows you to share the sensual experience of being there without straining a muscle, getting altitude sickness or losing control of your horse. Her use of words is... (Read More ...)
A Boomer's Guide to Cleaning Out Your Parent's Estate in 30 Days or Less: How to Empty the Family Home Without Losing Your Mind
A Boomer's Guide to Cleaning Out Your Parent's Estate in 30 Days or Less: How to Empty the Family Home Without Losing Your Mind By Julie Hall (The Estate Lady) http://www.TheBoomerBurden.com Reviewed by: Anne Holmes for the NABBW This step-by-step guide is a companion book to Hall's masterpiece, "The Boomer Burden- Dealing With Your Parents' Lifetime Accumulation of Stuff." It's a small book, six sections and 80 pages – but don't let the size fool you. This is the nuts and bolts of what you will need to actually wade into your parents home and get it cleaned out. It is chock... (Read More ...)
The Boomer Burden: Dealing with Your Parents' Lifetime Accumulation of Stuff By Julie Hall (The Estate Lady) http://www.TheBoomerBurden.com Reviewed by: Anne Holmes for the NABBW According to Julie Hall, every day, approximately forty-eight hundred Baby Boomers become middle-aged orphans when their elderly parents pass away, leaving them with a lot more than just memories. Having worked with thousands of clients over the past two decades in her capacity as "The Estate Lady," a leading national authority on conducting estate sales, personal property appraisals, liquidations and removal... (Read More ...)
Jed Diamond, Ph.D. has been a health-care professional for the last 45 years. He is the author of 9 books, including Looking for Love in All the Wrong Places, Male Menopause, The Irritable Male Syndrome, and Mr. Mean: Saving Your Relationship from the Irritable Male Syndrome. He offers counseling to men, women, and couples in his office in California or by phone with people throughout the U.S. and around the world. To receive a Free E-book on Men's Health and a free subscription to Jed's e-newsletter go to www.MenAlive.com. When I began training as a psychotherapist in 1965, I wanted to save... (Read More ...)


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The stock market rally since the beginning of the year is seemingly relentless. Regardless of whether the market related news is good or bad, stocks seem to fight their way higher day after day. This should not be mistaken as a signal for optimism about the U.S. economic outlook, however. Instead, the recent rally is purely the byproduct of aggressive monetary stimulus from the U.S. Federal Reserve. And recent history has shown that such rallies do not necessarily continue forever.
At the beginning of the year, the Fed added the purchase of U.S. Treasuries to its latest QE3 stimulus program. It has been no coincidence that the market has subsequently rallied almost without interruption ever since, as the stimulus program effectively amounts to the Fed dropping off a $4.5 billion bag of cash on the doorsteps of U.S. banks each and every trading day. Thus far, this cash has leaked its way into the stock market. But such preferences can change at a moments notice.
A look back at the Fed's previous balance sheet expanding monetary stimulus program highlights this point. In late 2010, the Fed launched QE2, which also included the outright purchase of U.S. Treasuries. And not long after the launch of QE2, stocks also entered into a seemingly relentless rally that lasted two and a half months. What ended the rally back in mid February 2011? The outbreak of the civil war in Libya is often cited as the reason, but a view across asset classes suggests it was simply a rotation out of stocks and into other asset classes. In other words, market preferences changed, as stocks ground sideways for the remainder of QE2 while other categories such as precious metals including gold and silver as well as long-term Treasury bonds soared.
Today, stocks under QE3 are following a strikingly similar path experienced under QE2. Looking ahead, if stocks today were to happen to continue this pattern going forward, it would imply the current rally on the S&P 500 Index would have another two weeks and +1.8% to the upside before hitting a comparable peak. Exactly where on the S&P 500 would this peak occur? At 1579, which just so happens to be effectively at the previous stock market peak first reached in March 2000 and revisited in October 2007. Given the fact that the stock market has approached this level twice over the last 13 years and subsequently went on to decline by roughly half, this level represents major resistance.
None of this means that stocks will fail this time around. After all, it's often said that the third time's the charm. So perhaps stocks will simply blow through this resistance and breakout to new highs. But given the widespread risks that continue to overhang the global economy and its financial markets, it is worthwhile to pay close attention to markets at these levels. And exploring what other opportunities may be currently presenting themselves beyond the stock market would be at a minimum prudent. It will be interesting to see how it all plays out.
This post is for information purposes only. There are risks involved with investing including loss of principal. Gerring Wealth Management (GWM) makes no explicit or implicit guarantee with respect to performance or the outcome of any investment or projections made by GWM. There is no guarantee that the goals of the strategies discussed by GWM will be met.


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Did you take a Twitter vacation over the weekend? If you weren't already aware, Beyonce just went right ahead and Beyonce'd again, releasing a (sort of) surprise album called Lemonade. Though it was previously only streaming on Tidal, for which you have to have a paid account, it's coming out on CD/DVD May 6th! You can preorder it now.
Anyone who's played her previous album to death, 2013's excellent Beyonce, knows they're in for something special. To boot, this new album features work by The Weeknd, James Blake, Jack White and Kendrick Lamar, plus samples and inspiration from the likes of Led Zeppelin, Yeah Yeah Yeahs, Soulja Boy and Animal Collective. Production was handled by Just Blaze, Diplo and Ezra Koenig of Vampire Weekend.


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Petasil Pose Black School Shoe
- Details
Petasil Pose a smart black leather school shoe. Gorgeous soft full leather upper, with a full leather inner. There are twin rip tape straps across the front to hold the shoe neatly in place on the foot. A soft padded heel, ankle and tongue. Comes with a removeable cork footbed, perfect for orthotic wearers who need to remove & exchange the insole. Solid synthetic flexible casual looking sole.
- Product Info
Additional Information
Colour Black Brand Petasil
- Reviews
Add Your Review +
Write Your Own Review
- Returns
If you are not entirely happy with your purchase you may return the goods to us within 30 days of receipt of your order for a refund.
All goods returned that were sent with free delivery will only receive a refund for the cost of the goods. If you have opted for an enhanced delivery service e.g. first class/next day & for all deliveries outside of the UK, these costs will not be refunded. Any return postage costs will be the responsibility of the customer.
We will always endeavor to refund you within 2-3 days of receiving the item.
For more information on how to return an item, please view our returns page.
- Delivery
We endeavour to dispatch your order within 1 – 2 working days. If for any reason we are unable to supply a particular item, we will contact you and offer a suitable alternative or a refund.
For more informaiton, view our delivery page.


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We have upgraded our system. To create a parent login and register your child for their School Fundraiser please visit GetMovinFundHub.com
Share your child's Student Fundraising Webpage
This is the key to success. Once your child is registered, share their webpage using the Share Tools provided to send e-mails to friends and family worldwide, or share the webpage on any social media platform. Parents that use the Share Tools to promote their child's webpage help their child raise an average of $150.00+ as opposed to students that just bring in cash or a check donations. Watch the video below to see how easy it is to share your child's fundraising webpage.
Raise the donation goal
If your child has reached or is getting close to reaching, their donation goal, go ahead and raise it so new visitors feel like they're helping your child achieve. You don't want them to leave because the donation meter is already filled up. Parents can easily login into their parent dashboard to edit/raise their child's donation goal.
Create a Parent Login shortcut - It's just like an app!
Parents can create a shortcut to bypass their parent login and go straight to their student profile right on their smart phones. Try it for easy access any time you want to check the status of your child's progress or share their Student Fundraising Webpage. Just follow these easy instructions:
Android User: Login to your parent profile, click the name of your student then click the 3 stacked dots in the upper right corner, select "Add to Home Screen," which will prompt you to name the page (Get Movin' is the default name). Change the name to your child's name, click "Add" and the webpage shortcut will appear on your phone's home page as a grey square icon of your home screen with your child's name under it.
iPhone User: Login to your parent profile, click the name of your child then click the upload symbol . Select "Add to Home Screen." which will prompt you to name the page (Get Movin' is the default name). Change the name to your child's name. Click "Add" and the webpage shortcut will appear on your phone's home page.
Send a thank you message to online donors
When logged into the parent dashboard, you're able to view a list of all online donations and sponsors under the "Donations" tab. The donor names and amounts of their donations appears next to a "Thanks" button. Press the button to easily send a quick "Thank You" message from you and your child to show your appreciation for their generous donation and support.
Employer match
Many businesses are willing and able to help their community. Why not ask your employer to match your child's donation total? We even make it easy for you. When logged in, you'll find a downloadable Employer Match Letter document that you can customize to suit your employer request.
How much profit is going back to my child's school?
Most of our clients keep an average 95% of the total amount raised. We are a company built and operated by former PTA/PTO Board members, so we know firsthand that schools need to keep as much profit as possible. We are a proud leader in high-profit percentages for fundraising organizations!
What if I registered my child but I didn't receive a confirmation email?
You don't need a confirmation email to access your child's webpage. Simply click the button on our home page to login to your parent dashboard where all your children's pages will be located.
What if I made a donation but did not receive a donation confirmation receipt?
Please fill out our Donation Confirmation form. Please note, the information entered must be the same information used when the initial transaction was processed.
Are Student Fundraising Webpages secure?
Yes, all student pages are secure and cannot be found through a search engine using the child's name in a browser. They are encrypted with a 12-15 digit code to make them very secure. The only way a person could find a student's page is if the parent chooses to share it via email or social media.
Who determines the donation rewards or prize incentives?
The school has 100% control over their donation reward incentives, in way of deciding, supplying and distributing them.
How can I attend my child's fundraising event?
Ask your school or parent group for the event schedule and plan to attend during your child's participation time. Often times, schools will post their event schedule on the school webpage, which is accessible from the student webpage.
Are donations for this fundraiser tax-deductible?
To be absolutely certain your pledge donations are tax-deductible, please check with your school or organization. Ask if they are a non-profit organization and what their 501c3 number is. All non-profit organizations have a 501c3 number issued to them by the federal government. In most cases, the IRS will require an official letterhead receipt for single donations exceeding $100.00 or more. Pease check with your tax accountant for all IRS rules and regulations.
Where do I get a receipt for my donation?
A receipt can be a copy of your check, the confirmation for your online donation transaction, or a credit card/bank statement. If the organization holds a non-profit status you can claim your donation on your annual taxes. If the amount of your donation is $100.00 or more the IRS (Internal Revenue Service) will want an official letter of receipt, including the 501c3 number. The receipt letter should be on the organization's letterhead with their 501c3 number and will indicate the total donation amount you made. Simply request this letter from the school/organization that you supported.


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The immune and inflammation-related pathway including the Toll-like receptors pathway, the B cell receptor signaling pathway, the T cell receptor signaling pathway, etc.
Toll-like receptors (TLRs) play a central role in host cell recognition and responses to microbial pathogens. TLR4 initially recruits TIRAP and MyD88. MyD88 then recruits IRAKs, TRAF6, and the TAK1 complex, leading to early-stage activation of NF-κB and MAP kinases [1]. TLR4 is endocytosed and delivered to intracellular vesicles and forms a complex with TRAM and TRIF, which then recruits TRAF3 and the protein kinases TBK1 and IKKi. TBK1 and IKKi catalyze the phosphorylation of IRF3, leading to the expression of type I IFN [2].
BCR signaling is initiated through ligation of mIg under conditions that induce phosphorylation of the ITAMs in CD79, leading to the activation of Syk. Once Syk is activated, the BCR signal is transmitted via a series of proteins associated with the adaptor protein B-cell linker (Blnk, SLP-65). Blnk binds CD79a via non-ITAM tyrosines and is phosphorylated by Syk. Phospho-Blnk acts as a scaffold for the assembly of the other components, including Bruton's tyrosine kinase (Btk), Vav 1, and phospholipase C-gamma 2 (PLCγ2) [3]. Following the assembly of the BCR-signalosome, GRB2 binds and activates the Ras-guanine exchange factor SOS, which in turn activates the small GTPase RAS. The original RAS signal is transmitted and amplified through the mitogen-activated protein kinase (MAPK) pathway, which including the serine/threonine-specific protein kinase RAF followed by MEK and extracellular signal related kinases ERK 1 and 2 [4]. After stimulation of BCR, CD19 is phosphorylated by Lyn. Phosphorylated CD19 activates PI3K by binding to the p85 subunit of PI3K and produce phosphatidylinositol-3,4,5-trisphosphate (PIP3) from PIP2, and PIP3 transmits signals downstream [5].
Central process of T cells responding to specific antigens is the binding of the T-cell receptor (TCR) to specific peptides bound to the major histocompatibility complex which expressed on antigen-presenting cells (APCs). Once TCR connected with its ligand, the ζ-chain–associated protein kinase 70 molecules (Zap-70) are recruited to the TCR-CD3 site and activated, resulting in an initiation of several signaling cascades. Once stimulation, Zap-70 forms complexes with several molecules including SLP-76; and a sequential protein kinase cascade is initiated, consisting of MAP kinase kinase kinase (MAP3K), MAP kinase kinase (MAPKK), and MAP kinase (MAPK) [6]. Two MAPK kinases, MKK4 and MKK7, have been reported to be the primary activators of JNK. MKK3, MKK4, and MKK6 are activators of P38 MAP kinase [7]. MAP kinase pathways are major pathways induced by TCR stimulation, and they play a key role in T-cell responses.
Phosphoinositide 3-kinase (PI3K) binds to the cytosolic domain of CD28, leading to conversion of PIP2 to PIP3, activation of PKB (Akt) and phosphoinositide-dependent kinase 1 (PDK1), and subsequent signaling transduction [8].
[1] Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors[J]. Nature immunology, 2010, 11(5): 373-384.
[2] Kawai T, Akira S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity[J]. Immunity, 2011, 34(5): 637-650.
[3] Packard T A, Cambier J C. B lymphocyte antigen receptor signaling: initiation, amplification, and regulation[J]. F1000Prime Rep, 2013, 5(40.10): 12703.
[4] Zhong Y, Byrd J C, Dubovsky J A. The B-cell receptor pathway: a critical component of healthy and malignant immune biology[C]//Seminars in hematology. WB Saunders, 2014, 51(3): 206-218.
[5] Baba Y, Matsumoto M, Kurosaki T. Calcium signaling in B cells: regulation of cytosolic Ca 2+ increase and its sensor molecules, STIM1 and STIM2[J]. Molecular immunology, 2014, 62(2): 339-343.
[6] Adachi K, Davis M M. T-cell receptor ligation induces distinct signaling pathways in naive vs. antigen-experienced T cells[J]. Proceedings of the National Academy of Sciences, 2011, 108(4): 1549-1554.
[7] Rincón M, Flavell R A, Davis R A. The Jnk and P38 MAP kinase signaling pathways in T cell–mediated immune responses[J]. Free Radical Biology and Medicine, 2000, 28(9): 1328-1337.
[8] Bashour K T, Gondarenko A, Chen H, et al. CD28 and CD3 have complementary roles in T-cell traction forces[J]. Proceedings of the National Academy of Sciences, 2014, 111(6): 2241-2246.
Products for Immunology/Inflammation
- 5-Lipoxygenase(11)
- Papain(1)
- PGE synthase(3)
- SIKs(1)
- IκB/IKK(37)
- KEAP1-Nrf2(11)
- NF-κB(18)
- Interleukin Related(5)
- 15-lipoxygenase(2)
- Others(10)
- Cat.No. Product Name Information
- C4158 (R)-Lisofylline anti-inflammatory agent
- C4161 (S)-Lisofylline inactive optical enantiomer of (R)-LSF, an anti-inflammatory agent
- C4298 (±)-Lisofylline anti-inflammatory agent
- B6391 2-TEDC 5-, 12-, and 15-lipoxygenase inhibitor
- C3283 2-Trifluoromethyl-2'-methoxychalcone Nrf2 activator
- C4050 6α-methyl-11β-Hydroxyprogesterone corticosteroid and anti-inflammatory
- A1025 a-MSH, amide Melanocyte-stimulating hormones
- B5638 ACHP IκB kinase inhibitor
- B7761 AI-3 Nrf2/Keap1 and Keap1/Cul3 interaction inhibitor
- A1051 alpha-1 antitrypsin fragment Protease inhibitor


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From Unify Community Wiki
Insert gobs of incomprehensible delegate-heavy C# AI code here.
I was going to put a link to my Subversion repository here, but I decided I didn't want any more spiders and scripted attacks hitting my server than I already get. ;) If you want to see my code, feel free to ask me on the Unity IRC channel.
To do
- Consider how file upload limitations should work. For everyone? Just for a specific group of users? Only by asking an administrator to upload it manually via FTP? Personally, I favour the latter, because it allows more quality control and better protection against abuse.
- Fix the broken syntax highlighter to stop it from syntax highlighting random divs all over the wiki.
- Fix image thumbnailing, which doesn't work for reasons of shell_exec() being disabled on the server. Here's a pretty test picture to remind me to do something about it:


text: Kristen Wiig Learn more about the fantastic Kristen Wiig by reading the pages in this section. Biography An in-depth look at Kristen's life and career. Awards and nominations A list of all the accolades that Kristen has won and been nominated for. Acceptance Speeches Read transcripts of the acceptance speeches Kristen's held. Audio Files Listen to clips from radio interviews, panels, music and more.