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Later Use of Clot-Buster After Stroke Possible: Study
Sept. 16 --
SUNDAY, Sept. 14 (HealthDay News) -- European researchers who showed that the clot-dissolving drug tPA could safely be used within three hours after a stroke now say the limit can be extended to four-and-a-half hours.
"We now have a three-hour limit mandated by authorities," said Dr. Nils Wahlgren, a neurology professor at the Karolinska Institute in Sweden and leader of an international group reporting Sunday in the online version of The Lancet. "Our data indicate that it is safe to extend that from three hours to four-and-a-half hours. The risk of hemorrhagic complications is not significantly different from the earlier time limit."
Tissue plasminogen activator (tPA), also known as the drug alteplase, is the approved treatment for the most common kind of stroke, in which a blood clot blocks a brain artery. The three-hour post-stroke time limit has been set because of fears that use of the clot-dissolving drug beyond that period might cause dangerous bleeding or other complications.
The new report is the latest from a study requested by European authorities after doubts arose about the safety of tPA in stroke treatment, which was approved in 1996 by the U.S. Food and Drug Administration. It was approved in 2002 in Europe.
The study compared the outcomes of 664 people who were given tPA between three and four-and-a-half hours after a stroke against almost 12,000 who received the drug within three hours of an attack.
The study found a death rate of 12.7 percent in the following three months for the three-hour group and 12.2 percent for those getting tPA later. In the early group, 58 percent achieved the ability of independent action, compared to 56.3 percent in the later-administration group.
"We recorded no significant differences between the 3- to 4.5-hour cohort and the within 3-hour cohort for any outcome measure," the researchers reported.
The bottom line, according to Wahlgren: "if patient treatment has been delayed, it is still safe to treat a patient beyond the time limit of three hours."
The results were expected to be presented at an international meeting in Stockholm in November, "when we will recommend a change in the guidelines," Wahlgren said. "I expect it would be accepted by the international community, both in the United States and Europe, and in the rest of the world."
But the new results do not necessarily mean an end to the three-hour limit, cautioned Dr. Larry Goldstein, professor of neurology at Duke University and director of the Duke Stroke Center in Durham, N.C.
"They are consistent with a combined analysis done some time ago that suggested we might be able to treat beyond three hours," Goldstein said. "But those were observational studies, as was this one. Controlled trials done to test that belief have not shown benefit."
It will take a change in the current guidelines to alter the three-hour limit, he said, and the overall benefit of tPA is greater when it is given earlier. "The sooner you get blood to the brain, the better," Goldstein said.
More information
There's more on tPA at the American Heart Association.
SOURCES: Nils Walhgren, M.D., professor, neurology, Karolinska Institute, Stockholm, Sweden; Larry Goldstein, M.D., professor of neurology, Duke University, Durham, N.C.; Sept. 14, 2008, The Lancet online


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When the pre-nominations for the 43rd annual Daytime Emmy Awards in the daytime drama performer categories came out we were really surprised Karla Mosley wasn't on the list.
Karla Mosley, Maya Avant on The Bold and The Beautiful, was given a very delicate and complex storyline: her character is a transgender and she's fought a lot to love herself, accept herself and let the others love and accept her. She's had so many family issues and she's now facing a surrogacy to become a mother. So, the themes the actress is treating are very relevant socially and she's so much appreciated for such a performance.
Karla has given her sweet character Maya lots of strength, passion and self-respect in several emotional scenes – such as the painful confrontation with her judgmental father Julius on her wedding day.
Her performance as Maya Avant was and still is powerful and sincere and she has shown her talent as a gifted actress. No matter she hasn't received any pre-nom to the prestigious Awards: for her fans all over the countries where B&B is loved she's a winner.
We love you, Karla!

subset: commoncrawl


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The many differences between James Steerforth and Tommy Traddles
In the novel, David Copperfield, Charles Dickens contrasts many different characters. The main two characters that he contrasts are Tommy Traddles and James Steerforth. He displays the contrast between these two characters in many different ways. The only common thing that they share is their close friendship with David. Dickens shows these differences through their looks, personalities, and the final results of their lives.
For one thing, Charles Dickens contrasts these two characters through their looks. He tells the readers that James Steerforth is an extremely handsome young person whom everyone seems to adore. In every instance in the book when someone sees him for the first time, they recognize him as being very attractive. He was described as being tall and thin character. On the other hand, Traddles was pictured as being somewhat on the heavy side. He reminds the reader of the fat clumsy kid in their own school.
Dickens portrays this when he says, 'Poor Traddles! In a tight sky-blue suit that made his arms and legs like German sausages, or roly-poly puddings,' (143).
Besides being different in appearance, Charles Dickens contrasts these two characters through their personalities. From the beginning, James Steerforth leads people to believe that he is a good person. There are many instances in which he shows off his true colors. The first sign of his deceitful manner occurs when David allows Steerforth to keep his money. Steerforth uses this money to buy food for many of the students. Steerforth displays his selfishness when he insults his schoolmaster, Mr. Mell, and gets him fired. Again, Steerforth shows his stern personality again when David arrives in London, and he is given a very small room over a stable. Steerforth confronts the hotel employee, and...


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I hate standardized tests. My daughter, a straight-A student at her elementary school, was freaking out over taking the PSSAs, the state-issued assessment tests in Pennsylvania, this week. She was a bundle of nervous energy, talking through a litany of "what if?" questions, all of which appeared to revolve around some kind of worst-case scenario. I suspect she will be on pins and needles until the results are announced.
The waiting game for test results is often stressful. Fortunately, for many tax preparers, the waiting game for the new return preparer competency test is coming to an end: the IRS has begun providing test results to those who have taken the test. Preparers who score at least 350 on the 120 question test (a perfect score is 500) will receive a passing grade. Those preparers who pass and have successfully completed a tax compliance check will be given the designation of Registered Tax Return Preparer.
For now, test results are being sent to tax preparers by letter. However, after April 16, 2012, results will be made available to preparers at the testing site immediately after testing is complete.
The test is part of the IRS effort to regulate preparers. Preparers have nearly two years to take the test. In addition, all paid tax return preparers must have a Preparer Tax Identification Number (PTIN) and pay an annual fee. Certain return preparers must also complete 15 hours of continuing education annually. Certified Public Accountants, attorneys (hooray!), and Enrolled Agents are exempt from the new continuing education and testing requirements. Also exempt are non-signing preparers supervised by CPAs, attorneys, or Enrolled Agents and those who do not prepare the federal form 1040 series.
You can schedule the test online at IRS.gov/ptin. Be prepared: it's not cheap ($116). That fee is in addition to the annual PTIN registration fee and any fees for continuing education.


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Featured Project: Dhamma Brothers
We are kicking off our monthly featured project for 2012 with Dhamma Brothers, a documentary film by Jenny Phillips. Phillips, who founded the Freedom Behind Bars Foundation, filmed what happened in an Alabama maximum security prison when Vipassana meditation was introduced to the prisoners. Men who were imprisoned for some of the most heinous crimes had to spent 10 straight days in silent meditation within the prison. Check out the trailer, then watch the film to see what happened before, during and after those 10 days.
Righteous Pictures is working with the director to build out the online community with the goal of driving awareness and increasing the number of prison meditation programs and volunteers within those programs. We have helped her update the website, build and grow the Facebook page, and become familiar with Twitter and YouTube. This Spring, Dhamma Brothers will premiere on Oprah's OWN network. So follow us on Twitter and Facebook to find out exactly when!
Phillips also wrote a book called Letters from The Dhamma Brothers to accompany the film. The book consists of letters written from the prisoners to Jenny after the 10 day program and filming had ended. The letters provide intimate access to the thoughts, dreams and challenges the Dhamma Brothers possess.


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Best bacon? We rank the house brands
College textbooks, courses and weekend festivities don't pay for themselves, so naturally you (and your parents) have been working hard to bring home the bacon. Hopefully you'll be getting a big tax return once you file Thursday. So why not bring home some actual bacon to celebrate? Nothing pleases like crispy pork --- except buying bacon while cutting some fat from your grocery budget.
Besides, numerous scholarly studies have shown that eating bacon leads to: higher test scores, more glowing skin, attracting the opposite sex..
We're glad you buy into those claims as wholeheartedly as we do. But is cheaper store brand bacon better than Oscar Mayer? For that matter, are store brands always cheaper than the main brand? In two cases, that's actually not the case.
Store Brand Scorecard ate Oscar Mayer bacon and three private labels -- one each from a big box store, grocery store and mini-market, respectively -- to see which hardwood or hickory wood-smoked bacon was the best value. Special thanks to Store Brand Scorecard reader Todd Rathbun for this suggestion.
Brand Name:Oscar Mayer
Cost: $2.78 at Walmart, $4.99 at a Chicago-area grocery store
Size: 16 ounces
Nutritional Facts: (For two slices) 70 calories (50 from fat), 6 grams of fat (9% recommended daily value), 15 milligrams of cholesterol (5% recommended daily value), 290 milligrams of sodium (12% recommended daily value)
Taste: Crispy and crunchy, with just a hint of smokiness and the perfect amount of salt. This brand of bacon's going to be pretty tough to beat.
The Big Box Store:Walmart
Store Brand Name:Great Value
Cost: $2.98
Size: 16 ounces
Nutritional Facts: (For two slices) 80 calories (60 from fat), 7 grams of fat (11% recommended daily value), 15 milligrams of cholesterol (5% recommended daily value), 320 milligrams of sodium (13% recommended daily value)
Taste: This fatty batch was a chore to chop through with a knife. No surprise, once cooked, that it was so chewy--too chewy. Too salty too.
The Grocery Store:Jewel-Osco (a Supervalu Inc. store. Supervalu, a Fortune 100 grocery retail company, also owns Albertsons, Acme, Shaw's and other grocery stores and pharmacies)
Store Brand Name:Jewel
Cost: $3.49
Size: 16 ounces
Nutritional Facts: (For two slices) 70 calories (60 from fat), 6 grams of fat (9% recommended daily value), 10 milligrams of cholesterol (3% recommended daily value), 200 milligrams of sodium (8% recommended daily value)
Taste: Impressive that Jewel's bacon tastes so salty succulent even with nearly 100 milligrams of sodium less than Oscar Mayer. But it's still too leathery, though not as hard to swallow as Great Value.
The Mini-Market:Aldi
Store Brand Name: Premium Pride
Cost: $2.49
Size: 16 ounces
Nutritional Facts: (For two slices) 90 calories (60 from fat), 7 grams of fat (11% recommended daily value), 15 milligrams of cholesterol (5% recommended daily value), 270 milligrams of sodium (11% recommended daily value)
Taste: Equal in fattiness to Great Value, and almost as hard to chew, Premium Pride's also has the smokiest taste, but it's so overwhelming, the bacon taste barely resonates on the tongue.
Greatest Value: How can Great Value bacon be a great value when it costs two whole dimes more than Oscar Mayer bacon does at Walmart--not to mention that its too salty and gristly? Value score: 4.
Aldi's Premium Pride is the most affordable, but the smoky flavor, while ambitious, is too overpowering. What a waste of perfectly fine pork. Value score: 5.
Jewel bacon deserves points for having less sodium than its counterparts – and it tastes better than two of them too. But while in the flavor department it comes in second, it's a far second. It also costs more than Oscar Mayer bacon at Walmart (although a dollar less than it does at Jewel). Value score: 6.
That leaves Oscar Mayer, the actual brand product, the winner of this challenge. The taste is so good, the bacon so crisp, its worth the extra cost at Jewel, and definitely worth the savings you get buying it at Walmart. Value score: 9.
Piet Levy's Store Brand Scorecard tests a major-label food product and three private-label equivalents to see which brand offers the best value for the price. It appears Mondays starting April 19. Send suggestions to Piet at email@example.com.


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Unboxing the Star Mobile Engage 7″ Tablet!
When in Manila and thinking of buying yourself a tablet to further satisfy your addiction to your social accounts but confused on which one to choose – don't worry! You're not alone! For many months now, I have been trying to find the perfect tablet to suite my needs as well as my budget! I'm very practical when in comes to investing in gadgets. As long as the features meet my needs, the brand for me doesn't really matter. As a blogger, it is a MUST for me to always be online and updated. Also, part of my job as Managing Editor for WhenInManila.com is to constantly work on many emails on a daily basis so it's really important for me to stay connected anywhere I go. I know that many of you are also like me, so Frank and I decided to show you the actual unboxing of my 1st ever tablet, Star Mobile's much awaited tablet the Star Mobile Engage 7″!
I'm really excited about this product! Here are its features….
The Star Mobile Engage 7″ Tablet operates on Android 4.0 ICS!
I love the fact that the Star Mobile Engage 7″ Tablet has a USB port so I can easily transfer media files from my pc to my tab!
the kit included an installer cd, a user manual, a charger and earphones
finally out of its cover! tadah!!!
Why 7 inches? Actually, at first, I wanted a 10″ tab but I realized it's way too heavy and inconvenient to carry. Having a 10″ tab would mean I always have to carry with me a huge bag! huhuhuhu I believe with my kind of lifestyle, a 7″ would be perfect for me! =)
various multimedia ports which you can connect to other devices
the Star Mobile Engage 7″ Tablet's design looked quite sophisticated. As you can see, the finish of its back looks sleek! We can't wait to open it!
as point of comparison, I borrowed Frank's tab. As you can see in the photo above, both tabs almost have the same thickness but the Star Mobile Engage 7″ Tablet is lighter than the other
and now the long wait is over — finally time to turn it on!
Star Mobile Engage 7″ Tablet
since it was our 1st time to open it, we were asked to setup my Google account
after Frank helped me set it up, I immediately tried the games! weeeeehheeeee!
trying out the camera.. SMILE!!!
All functions are working ok so far, I do hope that in the coming months, I won't have any problems whatsoever. All Star Mobile products go with a 12-month warranty so I don't need to worry. I just noticed that the resolution wasn't that high as compared with the one which we compared it with, but if you're the kind of person like me who only aims to have a very useful device to constantly be updated with various social media accounts, then I may say the Star Mobile Engage 7″ Tablet can be an ideal and practical tab for you!
Star Mobile
email: firstname.lastname@example.com
Facebook: Happy Man by Starmobile
Unboxing the Star Mobile Engage 7″ Tablet!


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Our principal mission is to provide educational opportunities to the students and parents we service. However, we also recognize the importance of athletic participation as a means of developing the whole person. Many of our schools are interested in students who are well rounded and who can bring a special talent to their schools, be it in music, acting, or athletics. Many of the Prep Schools encourage, and often require, that students be involved in at least two or more sports during the school year. Many IYM students have a special athletic talent that they bring to the boarding school experience, some leading to athletic scholarships to four-year colleges. To support student-athletes, with a special talent in basketball, IYM hosts an annual basketball showcase which is limited to 100 student/athletes and is attended by prep school coaches from around the country.
Boys & Girls Basketball Showcase >


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The Ciampac Hut is located at the entrance of the Vallunga in the Puez-Geisler Nature Park, surrounded by unspoilt nature, at the bottom of the Stevia Mountain. It is our special concern to spoil our guests with our traditional tyrolean cuisine and local gastronomic specialities. Our hut is easily accessible for everyone: on foot, by car, on skis or mountainbike.Mark Alexander - Te Ciampac iel tan bel | 2min 46s
Mark Alexander, a singer and violinist from Val Gardena has dedicated a song to the Ciampac hut.


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Where to Apply:
An identification number must be obtained from the State Racing and Wagering Board. Following that, permits for specific games of chance may be obtained at the Office of the Town Clerk
All games of chance, including 50-50 raffles, prize raffles, etc., are regulated by the State and require permits.
Additional information and applications forms may be obtained at the NYS Racing and Wagering web site reached through the Link below.


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Welcome to ObEN, where we are creating the future of Personal Artificial Intelligence (PAI). Our personalized digital avatars look, sound, sing, and behave like you, all secured and authenticated on the Project PAI blockchain.
Our proprietary full-stack AI combines speech, computer vision, natural language processing (NLP) and machine learning technologies to build PAI that leverage the continuous flow of new information on the blockchain-based network. By perpetually retraining our neural networks to adjust to new and ever-changing visual, acoustic, language, and behavioral cues, your PAI becomes smarter and more productive with every interaction.
Personal 3D Visual Avatar
Instantly create your personal 3D avatar from one selfie on your smartphone. Includes speech synchronization and emotive facial expressions.
ObEN's proprietary speech, vision and NLP technologies are built using deep learning techniques to leverage the continuous flow of new information every time one of our applications is used. By perpetually retraining our neural networks to adjust to new and ever-changing visual, acoustic and language cues, ObEN's personal avatars continually become smarter with further use.
Create your voiceprint from a short voice recording on your smartphone, to easily personalize any speech-enabled device.
Instantly create your personal 3D avatar from one selfie on your smartphone. Includes speech synchronization and emotive facial expressions.
Your personal avatar can perform a variety of skillful abilities ranging from singing, to initiating conversation to engaging in social activities.
ObEN is an artificial intelligence company that is building a decentralized AI platform for Personal AI (PAI), intelligent 3D avatars that look, sound, and behave like the individual user. Deployed on the Project PAI blockchain, ObEN's technology enables users to create, use, and manage their own PAI on a secure, decentralized platform - enabling never before possible social and virtual interactions. Founded in 2014, ObEN is a K11, Tencent, Softbank Ventures Korea and HTC Vive X portfolio company and is located at Idealab in Pasadena, California.
130 West Union Street,Pasadena, CA 91103 | firstname.lastname@example.com
© 2017 ObEN, Inc. All rights reserved
Privacy Policy and Terms of Use
[mailgun id="email@example.com"]


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1 to 1 FREE Immigration Consultations
One to One FREE Immigration Consultations with Home Office officials, with total anonymity! Sound to good to be true? Then listen to Dr Erinma Bell and Charles Kwaku-Odoi discussing on @RadioAfricana on #TheCarismaShow. Listen to the Podcast here. Download a leaflet with more information here.
We are live!
The new Carisma website is now live at www.carisma.me.uk. It is still under construction. More information will be added soon.
Carisma's Dr Erinma Bell taking part in a special service at Manchester Cathedral to mark 70 years since the arrival of the ship Windrush to the UK from Jamaica. Erinma was asked, as a guest, to deliver the Act of Remembrance in the form of Libation. The service showcased a new 'Windrush Cope', ceremonial robe featuring black history. The Themes were: Remembrance, Togetherness and Building for the Future.
The service followed a conference earlier in the day, also at the Cathedral, wth the aim to chart a new course for the descendants of the 'Windrush Generation'. It was facilitated by the 'Windrush Defenders', a group of lawyers, law graduates and community activists who have come together in the UK, working pro bono and facilitated by FM Legal, The Law Center, to help those who are affected by the Windrush Scandal.
News, views and comment
November 2019


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Book–Amateur comic book artist and high school student Jess Wong is painfully, unhealthily in love with her best friend Angie. Jess is content to obsess over Angie secretly until Angie enters into a relationship with Margot Adams, a beautiful student from the nearby posh boarding school. Naturally, Jess thinks Margot is no good for Angie, but is this just sour grapes on Jess's part or is Margot really bad news? When tragedy strikes at an off-campus party and everyone is a suspect, Jess must face up to what really happened that night. Or must she?
This is a dark, twisty thriller, like Pretty Little Liars meets Gone Girl meets The L Word. The book is split in two parts: the beginning is told in first person from Jess' POV and the end is made up of police interviews and third person limited POV following multiple characters. This allows Lo to build up the tension without giving it all away too quickly. If you enjoy A Line in the Dark, you might also like twisty young adult books like We Were Liars and Last Seen Leaving.


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U.S. Postal Service Records Loss of $354 Million in First Quarter, Underscoring Need for Comprehensive Legislation
The U.S. Postal Service ended the first quarter of its 2014 fiscal year (Oct. 1, 2013 – Dec. 31, 2013) with a net loss of $354 million. This marks the 19th of the last 21 quarters that it has sustained a loss. Though the Postal Service has been able to grow revenue by capitalizing on opportunities in Shipping and Package Services and has aggressively reduced operating costs, losses continue to mount due to the persistent decline of higher-margin First-Class Mail, stifling legal mandates, and its inflexible business and governance models.
"The Postal Service is doing its part within the bounds of law to right size the organization, and I am very proud of the achievements we have made to reduce costs while significantly growing our package business," said Postmaster General and CEO Patrick Donahoe. "We cannot return the organization to long-term financial stability without passage of comprehensive postal reform legislation. We appreciate the efforts of the House and Senate oversight committees to make this happen as soon as possible."
Without legislative change, the Postal Service will be forced to default on another required $5.7 billion retiree health benefits prefunding payment due by Sept. 30, 2014, because it will have insufficient cash and no ability to borrow additional funds at that date.
The Postal Service will continue to have a low level of liquidity through October 2014. In the event that circumstances leave the Postal Service with insufficient cash, the Postal Service would be required to implement contingency plans to ensure that all mail deliveries continue. These measures could require the Postal Service to prioritize payments to its employees and suppliers ahead of some payments to the federal government, as has been done in the past.
Citing that the Postal Service could not wait for legislation indefinitely, the Postal Service's Board of Governors directed management in 2013 to accelerate alignment of its operations to further reduce costs and strengthen its finances. The Postal Service leveraged employee attrition and increased use of non-career employees-as provided by new labor agreements-which allowed for better alignment of staffing and workload levels, resulting in reduced labor costs.
"We grew revenue by over $300 million through aggressive marketing and improving service, and we reduced operating costs by $574 million in Quarter 1, partially due to the separation of approximately 22,800 employees in 2013 under a Voluntary Early Retirement program and improved efficiency in our workforce," said Chief Financial Officer and Executive Vice President Joseph Corbett.
First Quarter Results of Operations Compared to Same Period Last Year
- Total mail volume of 42.0 billion pieces compared to 43.5 billion pieces
- First-Class Mail volume declined 4.6 percent.
- Standard Mail volume declined by 2.8 percent.
- Shipping and Package volume increased 10.3 percent.
- Operating revenue of $18.0 billion, an increase of $334 million or 1.9 percent
- Operating expenses of $18.3 billion compared to $18.9 billion, a decrease of 3.0 percent
Revenue from First-Class Mail, the Postal Service's most profitable service category, decreased $209 million, or 2.8 percent from the same period last year, with a volume decrease of 817 million pieces, or 4.6 percent. The most significant factors contributing to this decline were the ongoing trends in the mailing behavior of consumers and businesses emanating from the recent recession, and the continuing migration toward electronic communication and transactional alternatives.
The Postal Service's shipping business continues to show solid growth. Shipping and Package revenue increased $479 million or 14.1 percent over 2013 first quarter results, fueled by the growth of online shopping, Sunday deliveries in limited U.S. markets and the ongoing success of Postal Service campaigns to promote the value of Postal Service shipping services. The Postal Service continues to capitalize on its competitive advantage in providing "last mile" service, resulting in a 34.3 percent increase in revenue from Parcel Return and Parcel Select Service over the same period last year.
Complete financial results are available in the Form 10-Q, available at http://about.usps.com/who-we-are/financials/welcome.htm.


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Accompanied by a settlement security officer, IDF soldiers abuse a Palestinian boy and avoid giving him proper medical attention.
By Yesh Din, written by Yossi Gurvitz
One day in May M., a 13-year-old child from the village of Qariut left his school and headed to his father's lands to find out what his chores were for the day. Unfortunately for M., the village's land borders a plit seized for protecting the settlement of Eli. M. was already used to settlers disrupting his family members while tilling their lands, and he learned to identify the settlement's security personnel.
Soon after M. reached the plot of land, a civilian security officer from the settlement also arrived. His behavior was unusual: M. says he pointed a gun at him, shouted that he was mad and yelled out a few more words in Hebrew that M. didn't understand. Then the security officer fired his gun in the air. M. panicked and started running; he stumbled, fell and broke his leg in two places.
The shots were heard in the village and B., a village council member who's also a Red Crescent volunteer, raced to the scene, video-taping as he drove. What he saw was shocking, and you can see it below.
Soldiers who reached the scene after the shots were fired circled M. and threatened him with their weapons. At 0:22 the security officer is seen returning to the scene. M. said that one of the soldiers tried to lift him up, and the video shows (0:57) how the soldier twists the child's broken leg. M. said he screamed in pain and begged the soldier to stop – the camera is too far away for the audio to be heard. A short while later (1:18), the security officer draws his gun at the wounded child. M. says that some point, he put it against his head.
You don't have to be a medic to know that you don't move a wounded person, yet this is precisely what the soldiers tried to do. Despite M.'s begging, they stop. It seems that causing pain to a Palestinian boy's broken leg didn't unduly bother the soldiers.
At the same time, B. and other Red Crescent volunteers, all of them in clearly marked vests, advanced towards the soldiers. At this point the security officer turned his weapon towards them and threatened to fire. The medics approached the scene nevertheless; the soldiers took the security officer from the scene, and demanded only one medic approach the boy. B. made his way to him and set his leg. He demanded the soldiers call an ambulance, but they refused and informed him they will take care of M. themselves. B. wondered just how were they going to treat a person they just beat up, and was ignored. A woman who identified herself as an army doctor told B. not to worry. He repeated his request for an ambulance and demanded that M. be evacuated to a hospital, but to no avail. The soldiers put M. in a jeep, and drove off, the security officer with them.
After driving towards the settlement of Eli, according to M., an Arabic-speaking soldier repeatedly tried to make him confess to trying to infiltrate the settlement in order to commit a felony. M. strongly denied it and the soldier drew a knife and threatened to use it on him. At one point, according to M.'s report, the security officer went over to him and twisted his wounded leg several times, as he was screaming in pain. He was left in the jeep for some two hours or more.
Later on the IDF doctor showed up, injected M. with morphine and glucose and transferred him to the Red Crescent. As a result of his wound, M. had to undergo an operation, and the doctors says the neglect caused him noticeable harm.
So, let's take stock: soldiers taking orders from a civilian; soldiers and an armed civilian who point their guns at a wounded child and at Red Crescent medics; soldiers denying a wounded child the medical care he requires, and treat him as a beast of burden, moving him to and fro; Soldiers insisting on interrogating him contrary to law (which requires an adult, preferably a parent, present during the interrogation of a minor); an armed civilian torturing a child in the presence of soldiers, who do not stop him; a doctor refusing to evacuate a wounded child to a hospital or provide him with proper medical care, delays his treatment and allows soldiers to hold and interrogate him- with this delay, it is suspected. That's what made the operation necessary.
Another day under occupation; nothing out of the ordinary. Except this time we have not just the testimony of the Palestinians, always discounted by Israelis, but also a video. If Israelis were truly patriotic and zealous to their country's good name, they would react with horror to the officers and armed civilians who transformed their military into such an assembly of thugs, of doctors who made a mockery of their Hippocratic Oath. They would have said it is inconceivable that an army created to protect war refugees would behave so brutally towards children, whomever they may be.
But Israelis have already internalized the occupation and know its price full well; they just dislike being reminded of it. So here is a reminder, nevertheless.
Written by Yossi Gurvitz in his capacity as a blogger for Yesh Din, Volunteers for Human Rights. A version of this post was first published on Yesh Din's blog.


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Ph: (08) 9472 5000
Victoria Park Floor Covering
Ph: (08) 9472 5000
When we sell, quality & service comes first. We never compromise on these! Right across our range, we're always striving to get and give our clients the best value for their money.
We stock and sell a variety of Carpets, Carpet Tiles, Laminates, Vinyl (Both sheet and planks), All types of Window Blinds, Timber & Bamboo Flooring and Artificial Grass. Please feel free to click and browse the links at the side to view what we stock. We've a comprehensive range at our showroom based in East Victoria Park – Albany Highway.
We cater for both the domestic as well as the commercial sectors of the market.


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Judgement Day
Judgement Day will not be until the end of the 1000 year kingdom. We know that because the Bible tells us "the dead (those who have not survived the tribulation) will not live again for 1000 years." But why is that?
Probably because the sheer number of people who would have to be supported for 1000 years on the New Jerusalem, which is in orbit around the earth while the earth is "renewed", is just too many! Even if they could be accommodated, it obviously makes sense to wait until the earth has been renewed and there is then room to rehouse everyone.
At that time everyone, including those who boarded the New Jerusalem alive, will be judged. We will not deal with the first and second death because no one is going to die at Judgement Day! It will just be a reclassification! So how can we all be judged? Where are all the records kept?
A complete, compact and accurate record of a person's life is the one stored in each individual's brain, much of it, presumably, in the subconscious. With the correct equipment to "read" the person's brain, a complete record of the person's life might be retrieved. Are the people being judged the one "seated on the thrones", rather than those carrying out the judging? If so, are they about to have their memories "read" and "retrieved"? Are there "scanners" at work here?
If you consider this to be too much like a sci-fi story, just look at a new developments in computers announced recently. On 4th February 2012 an article appeared in a daily newspaper to announce that a computer has been developed to read thoughts. A full page of the details was published in The Mail on Sunday on 5th February 2012.
The article reads: "Neuroscientists at the University of California Berkeley put electrodes into the skulls of brain surgery patients, to monitor information from their temporal lobes. As the patient listened to someone speaking, the computer program analyzed their brains and reproduced the words they had heard".
As far as the Bible is concerned, only those "whose names are written in the Book of Life from the beginning of the world" will be resurrected. But what is this "Book of Life" and how can dead people be brought back to life??
Modern science has advanced today to the point where scientists can clone an animal, given a sample of tissue or bone, even if the animal is dead. But this is the very beginning of the cloning age and of decoding the human genome. In theory, given the DNA code of an individual, a new clone could be created from this information alone, without a sample. Is it possible that this "Book of Life" has the DNA records of every person who has ever lived in it?
If a "Book of Life" does exist, it would have to be on a computer infinitely larger and more powerful than any we have developed today, or can even imagine. However, looking at scientific advances in the last 50 years, it is not impossible to envisage that a race, sufficiently advanced to build "The New Jerusalem", could have the technology to have developed this capability.
How far back would this information go? Would it go back to the first homo-sapiens or only 2000 years, to the time of Jesus?
Developing a new body from the known DNA, however, would not resurrect the original individual. The clone would have none of the memories, or experiences of the original being. So how could we put the original memories into a newly created clone?
The brain is very similar to a computer! It can absorb information and store it as a memory. On a computer, a memory can be easily uploaded elsewhere, for instance to a disc or another computer. In fact, once a day, a computer is regularly backed up to a server, where a complete record can be stored and maintained as a reserve should the original computer fail. It can then be downloaded at any time in the future from the server, on to a new computer, even after the old computer has "died".
In theory then, a memory could, given the technology, be downloaded from the information held on "the server" and transferred into the new clone. The new individual would then have all the memories of the original and even look like the "original!"
But one question remains. How can a human memory be uploaded to a "computer" in the first place and is there any evidence to suggest it is actually happening?
Spiritualists claim to have photographed a barely visible, silver stream of energy leaving the body on death, which they claim is the "soul" departing to "heaven". Some have claimed that the same phenomenon occurs when a person sleeps, although in this case the "soul" remains attached to the body by the silver thread, whereas on death the "thread" is broken.
Is it possible that the stream of "energy" photographed could be a stream of "information", which is being uploaded to a "back-up" facility whenever the body sleeps, with a final back-up when the body finally dies?
If so, in theory, allowing for a huge development in technology, physical resurrection could be a scientific possibility and the development of a computer which can apparently "read" the brain, as discussed previously, is a huge step in the direction of recording memories. A step presumably taken long ago by our "Guardians"
11 Then I saw a great white throne and him who sat upon it; from his presence earth and sky fled away, and no place was found for them. 12 And I saw the dead, great and small, standing before the throne, and books were opened. Also another book was opened, which is the book of life. And the dead were judged by what was written in the books, by what they had done.
Note there are two books, just as we discussed earlier. One is the Book of Life containing the DNA information, the other "book", actually a computer, could contain the memories.
Although the "Book of Life" is frequently mentioned throughout the Book of Revelation, this is the first and only time this second book is mentioned and gives must give some support to this incredible theory.
(13) And the sea gave up the dead in it, Death and Hades gave up the dead in them, and all were judged by what they had done. 14 Then Death and Hades were thrown into the lake of fire.
Figuratively, Death and Hades have been terminated. They no longer exist, but our spiritual "mentors" cannot resist one last reminder that if we fail to toe the line, we too will go into the fire!
This is the second death, (for those who have been resurrected, otherwise it would be the first death for those who had survived the Great Tribulation) the lake of fire; 15 and if any one's name was not found written in the book of life, he was thrown into the lake of fire.
The last statement about the fate of anyone whose name "is not written in the book of life" should strike terror into those who have previously been labelled "those who dwell on the earth, whose names are not written in the Book of Life"
Most unfair on Muslims, who make up a quarter of earth's population, who all believe in Jesus and most of whom expect him to return! Whoever labelled them as such obviously either didn't give much thought to the subject of the Muslim faith, or really didn't care!
This illustrates just how much the original texts have been corrupted over the centuries by those who have been able to do so, to promote their own interests and interpretation of the Bible because the Bible makes clear that its message is for all races and nationalities and if there is a Book of Life, I'm sure everyone's name will be in it, at least from the date it was established!


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To understand recent advances in the medical management of tenosynovial giant cell tumors (TGCT), join our expert faculty for a discussion on approaches you can take to achieve tumor size reduction and improvements in physical function, pain, and quality of life for your patients with TGCT.
CME: Tensynovial Giant Cell Tumor (TGCT): New Perspectives on Advances in Treatment
Tenosynovial Giant Cell Tumor (TGCT): New Perspectives on Advances in Treatment
Tenosynovial Giant Cell Tumor (TGCT): New Perspectives on Advances in Treatment
Tenosynovial Giant Cell Tumor (TGCT): New Perspectives on Advances in Treatment
Welcome to CME on ReachMD. This activity, entitled "Tenosynovial Giant Cell Tumor (TGCT): New Perspectives on Advances in Treatment" is provided by Prova Education and is supported by an independent educational grant from Daiichi Sankyo. Prior to beginning the activity, please be sure to review the faculty and commercial support disclosure statements as well as the Learning Objectives.
Dr. Tap:
Tenosynovial giant cell tumor, or TGCT for short, are rare, non-malignant tumors that can involve the joint synovia, bursa, or even the tendon sheath, leading to significant morbidity and compromise quality of life. While many patients can be treated with surgery, surgery is not necessarily a cure. And what happens when surgery is not an option?
This is CME on ReachMD, and I'm Dr. William Tap. Joining me to discuss the surgical and medical management of TGCT are Drs. Sylvia Stacchiotti, Andrew Wagner, and Michiel Van de Sande.
Welcome to you all.
Dr. Tap:
TGCT is certainly a rare condition that frequently goes undiagnosed for quite some time. Dr. Wagner, can you tell us a little bit about TGCT? And can you please walk us through some of the important things we should know about this disease?
Dr. Wagner:
Sure. Tenosynovial giant cell tumor, or TGCT, sometimes called pigmented villonodular synovitis is a rare condition. It typically presents in the joints; most typically in the knee or hip or ankle, but it also can occur as a similar condition in the fingers or the flexor compartments of the limbs. It can affect people of any age, although it is something that commonly affects younger people; young adults in their 20s, 30s, and 40s. Because these are usually very active people, it often shows up as a swollen joint that can be painful and is thought to be traumatic. And the patient will often present to an orthopedic surgeon or sports medicine specialist. Sometimes it can take awhile to reach a diagnosis because of the possibilities of other diagnoses. It often will be clearer on imaging, if imaging is performed, such as an MRI scan with a characteristic appearance. And this can be confirmed by biopsy. What's become really interesting about this tumor is the discovery several years ago of the characteristic translocation in the cells in the tumor. A small proportion of the cells are actually the neoplastic cells. These cells contain a characteristic translocation involving a collagen gene and the gene-encoding protein called CSF1. This leads to constitutive overproduction of CSF1, and these cells then draw in other normal cells, normal inflammatory histiocytic cells, to form this tumor mass. The mass is very inflammatory and can cause pain, can cause joint destruction, and can cause swelling, can cause bleeding within the joints. And this is what leads to the clinical presentation of patients.
For some patients with tenosynovial giant cell tumor, surgery alone can cure them of their disease, but unfortunately for many others, the disease recurs. And if the disease remains in the joint space, it can cause really significant morbidity. This can lead to destruction of cartilage and accelerated arthritis, leading to early joint replacement. It also can cause pain, functional limitations in terms of range of motion, and joint instability. So our patients that we see with advanced disease in the joints can really be suffering. They often are on narcotic pain medications, and in some cases antidepressants. Some are unable to work because of their symptoms. These are patients who often no longer have an acceptable surgical outcome. And for these, we really need to find an effective medical therapy.
Dr. Tap:
So, when we are presented with a patient with TGCT, Dr. Van de Sande and Dr. Stacchiotti, how do you determine if this patient is a good candidate for surgical management? Or may possibly be suited for medical management?
Dr. van de Sande:
Thank you for that very interesting question. It's I think very important to differentiate patients that are primary patients that have never had any treatment before to patients that have had many treatments before already. And if there are patients with a long history of surgeries or systemic treatment, even radiotherapy, it becomes more and more difficult to successfully remove the tumor tissue from the joints and keep functional joints and a happy patient after the surgery.And other factors, of course, that make us decide if surgery is still possible are both patient-specific factors such as location in the body, but also in and around the joints because when it's outside of the joint, it's less easy to take out the tumor without morbidity to either the joint or the extremity. So location and former treatment both are important factors for us to decide if surgery is possible. Finally, I think describing a single patient that is not suitable for surgery is very difficult. And the optimal way to assessing who should benefit – who could benefit from surgery and who could benefit from systemic treatment is a decision that needs to be made together with the oncologist, the patient, and the surgeon. So all sides of the treatment, both response rates or surgical success rates versus complications and side effects need to be addressed, and then the patient together with their whole team of physicians can make a decision for either surgical or either nonsurgical treatment.
In patients with a localized disease, often the resection is simple, and therefore not very difficult. It makes postoperative rehabilitation short and pain easily managed with light pain medication. But if it's disease diffuse in the joints, even outside the joints, it becomes a larger resection, and I would specify for the knee, as most patients in about 65% have the location of the TGCT in the knee, tumor in the front of the knee intraarticular is painful to resect, and when you resect it, the postoperative time in hospital is often five days. They are under general anesthetic and use epidurals to have sufficient pain relief and be able to directly start with rehabilitation and flex the knee. The surgical resection of the extraarticular location mostly in the back of the knee in the posterior side of the knee is less painful, but still provides patients with an incision and a scar in the front and in the back of the knee. And this needs to be balanced with the risk of having a local recurrence for diffuse disease, which is, according to our publication in The Lancet, around 50% within five years. So if patients would accept a high risk for local recurrence within five years, but a long rehabilitation period after the surgery, the surgery is still a good option.
Dr. Tap:
For those just tuning in, you're listening to CME on ReachMD. I'm William Tap, and today I'm speaking with Drs. Stacchiotti, Wagner, and Van de Sande regarding the management of tenosynovial giant cell tumors or TGCT.
Dr. Stacchiotti, in a scenario where surgery is not the most optimal approach, what options do we have at our recourse as medical oncologists for the treatment of TGCT?
Dr. Stacchiotti:
So based from what we know from clinical studies and clinical experience, a medical treatment for TGCT patient is advisable, if available, in adult patients suffering of local regional advanced relapse of TGCT, not amenable of surgical resection, suffering of the symptoms, and with radiologic evidence of disease progression, or even symptoms are not there, the radiologic evidence of progression can be enough when the disease is located at a critical site. Patients should be, of course, very clearly informed of the benefit expected with the treatment and also of the risk of side effects, which is related to the treatment, the medical treatment they are going to receive. Available treatment currently varies a lot across countries.
Dr. Tap
So, thank you, Dr. Stacchiotti. I think it's critical, as you said, to truly understand what are the needs of our patients, and potentially what are the goals of treatments that we're trying to offer them. And this is something that often comes out with long discussions with our patients. I think the other important thing to realize is sometimes when patients come to tertiary care centers that really have expertise in this disease, there can be tremendous improvements in symptoms just by bringing in supportive care services; physical therapy, better pain control, and actually beginning to discuss with patients what we may actually be able to do from a medical standpoint to improve their conditions. Then, we really can start to think about medications and when is the appropriate time to use those medications. I often find that even with just supportive care measures, we can even begin to delay the use of medical treatments for our patients. And then when we do decide to use them, we have to think about the risk profile of the different medications that we have available in the United States. We are fortunate here that we can often use drugs such as imatinib and nilotinib off label. These are weaker inhibitors of CSF1 receptor, and so they can allow for improvement in conditions, but we tend not to see the dramatic shrinkages in the size of the tumor mass that we can often see with some of the stronger CSF1R inhibitors such as pexidartinib. However, the side effect profile of these drugs are well known. We often use these drugs in many of our patients with certain malignancies. So we can really set the expectations for our patients. I think our patients do understand that with these drugs we can often allow for stability, potentially some slight shrinkage of their disease, but really help with symptoms. Alternative to this is the stronger CSF1R inhibitors such as pexidartinib, which has been approved by the FDA, or even newer drugs coming out
on clinical trials. With these drugs, we tend to see dramatic improvements in the tumor mass, inflammation, as well as quick improvement in symptoms that are related to TGCT. Oftentimes, as been discussed before, patients may have other issues with their joint because of the long-standing disease, the joint destruction that it caused, or even the various surgeries they may have. These types of symptoms need to be mitigated with other supportive services, as I mentioned before. But regardless, with the use of drugs such as pexidartinib, we have to have strong considers of some of the rare toxicities that we're seeing with this drug, such as we mentioned before, such as the cholestatic hepatotoxicity. This is a very rare and unpredictable side effect of the drug, and we really have to educate our patients about determining if the drug is right for them. And I think this is critical in the informed discussions that we can have with our patients.
Dr. Tap:
So, as Dr. Stacchiotti mentioned, we do now have one approved therapy, pexidartinib, in the United States for patients with TGCT. Dr. Wagner, can you provide some information on how this agent works? And maybe walk us through some of the results of the Phase 3 ENLIVEN study that supported its approval?
Dr. Wagner:
Sure. This is the first prospective placebo-controlled study of a drug in patients with tenosynovial giant cell tumor. It enrolled 120 patients who were randomly assigned to receive either pexidartinib or placebo in a blinded fashion. They received the study drug for up to 24 weeks, at which time their assignment could be unblinded and patients were then permitted to cross over the pexidartinib if they were found to have received placebo in the first 24 weeks. The results were pretty impressive. There was 39% response rate by RECIST in patients receiving pexidartinib in those first 24 weeks, and 0% response rate in patients receiving placebo. Now one of the real challenges of tenosynovial giant cell tumor is in how we measure the disease. It is not a spherical lesion that has very defined dimensions. It is very typically multilobulated, extending in different dimensions, and there is no simple way to measure the volume, and there's no simple way to measure the extent of disease. RECIST is not a perfect tool for this, so another metric called the Tumor Volume Score was developed that determines the size of the tumor in proportion to the maximally distended volume of the synovial cavity. Using this metric, the response rate was even higher; now 56% in patients in the first phase, the first 24 weeks of the study. With further follow-up, both by RECIST and the Tumor Volume Score, the response rates increased further, suggesting that patients did not necessarily all reach their maximal benefit in those first 24 weeks. In addition to measuring changes in the size of the tumor, the study also measured changes in patient-reported outcomes, including the PROMIS physical function scale, range of motion, patient-reported stiffness and pain, and shows statistically significant improvements in these with the exception of pain where there was a trend to improvement that did not meet statistical significance. So altogether from an efficacy perspective, pexidartinib resulted in a greater reduction in the size of the tumor and improvement in patient symptoms compared to placebo.
Dr. Tap:
So, Dr. Wagner, I think that was really well said. I chose the complexity of this disease, the complexity of the outcome measures within this study, but also how this drug really helped patients with TGCT. Importantly, what you also highlighted was again this rare cholestatic hepatotoxicity, which is unpredictable and can be serious for some patients. This really calls into mind, now that we have a drug approved, what is the best way to use this drug? Are there ways that we can mitigate and watch for the potential of any cholestatic hepatotoxicity with the drug? And what may be the right patient population to use this drug? And what are we looking for in responses?
Dr. Stacchiotti:
Following what Dr. Wagner was saying, my general comment is that this study was a great opportunity for us as a community of experts in the disease to better know this tumor. And my general comment is that is really crucial to select the right patient in which there is a perfect balance between the benefit and risk. This can be done only within the center of expertise because it is the only setting in which it is possible to really identify the good patient for medical treatment. This has to do with disease that is said to be a benign tumor, and in fact the risk of metastases in these tumors is almost 0, but in which especially along the natural history of the disease, the tumor can be very aggressive and can impact quality of life very much.
Dr. Tap:
So, this has been a fascinating discussion, but our program is unfortunately is coming to a close. So, let's offer our learners some parting thoughts. Dr. Van de Sande, let's begin with you. What is one key takeaway for our audience?
Dr. van de Sande:
Thank you very much, Dr. Tap. I think it remains of crucial interest that we discuss our possibilities and limits with the patient in a team where there is sufficient experience in both the surgical, but also the systemic treatment of this very rare disease that most of the time – I think the key take-away from a surgical point of view is that we need to communicate our options and our successes, but also our complications in honesty, and preferably together with the oncologists in order to create an honest shared decision-making to patients with a really rare disease.
Dr. Wagner:
I completely agree with the comments of Dr. Van De Sande and Dr. Stacchiotti. This was a remarkable experience where we could unite the international community in conducting a randomized study in a rare tumor. A drug that showed clear signs of efficacy, but also with a caution that there is close monitoring that is required, and it's also very important and remains very important for this to be a multidisciplinary team that is evaluating the patient and deciding on the best treatment. For some patients, surgery is still the most appropriate therapy, and that needs to be carefully considered. But for others, medical therapy may be warranted, and hopefully can continue to provide good benefit for patients with minimal toxicity.
Dr. Stacchiotti:
Following what was said by Dr. Wagner, the activity of pexidartinib and other potentially active drugs in this disease, is a major achievement for our patients. I think that what is difficult to understand is that TGCT is said to be a benign disease, and this is related to the risk of metastasis is really very low, almost 0. So we are dealing with a disease which has a locally aggressiveness, but not a metastatic risk. This means that there is no impact in the survival of our patients, but still there can be really a major impact in the quality of life. That is something we are seeing almost every day in our clinic where we have a patient in need of something to improve their quality of life. This is very difficult to understand, and this is part of the discussion we had and we are still having with regulators to try to let them understand that there are really patients in the need for medical treatment. What is absolutely crucial is to identify the right patients. So to have a very good selection of the patients to avoid unnecessary toxicity for those patients who do not need medical therapy, and to offer what is needed for those patients who are in the need of medical therapy. This can be done only within the center of expertise, where you can join together surgeon, orthopedic surgeon, and medical oncologist; able to really identify which is the right patient for the treatment and to talk with the patient, sharing with him which is the balance between the expected benefit and toxicity.
Dr. Tap:
So this has been a wonderful discussion. For me, what's important is actually forming this multidisciplinary team around our patients with TGCT. The patient must be very much included within these discussions and informed about the options we have; both surgical and medical, and the pros and cons of each. Important with this multidisciplinary team now inclusive of the patient is trying to figure out what is the right way to develop therapies and actually appropriately apply some of the new medical treatments that we have for that. This is going to be critical in the upcoming years for our patients in the academic community to partner with so we can best serve them with some of the new medical treatments that are being developed.
So, as we wrap up our discussion, I'd like to thank my guests, Sylvia Stacchiotti, Andrew Wagner, and Michiel Van de Sande, for helping us better understand new options for the management of TGCT. It was really great speaking with all of you.
You have been listening to CME on ReachMD. This activity is provided by Prova Education and is supported by an independent educational grant from Daiichi Sankyo. To receive your free CME credit, or to download this activity, go to ReachMD.com/Prova. Thank you for listening.
- Host: William D. Tap, MD
- Guest: Silvia Stacchiotti, MD
- Guest: Michiel van de Sande, MD, PhD
- Guest: Andrew J. Wagner, MD, PhD
Patients with tenosynovial giant cell tumors can be managed with surgery, but it's not a cure. And what happens when surgery is no longer an option?
Available credits: 0.25
Time to complete: 15 Minutes
Valid until:
Disclosure of Conflicts of Interest
In accordance with the ACCME Standards for Commercial Support, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any commercial interest. GLC resolves all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.
William D. Tap, MD
Chief, Sarcoma Medical Oncology Service
Memorial Sloan Kettering Cancer Center
New York, NY
Leadership: Atropos Pharmaceuticals, Certis Oncology Solutions
Ownership Interests: Atropo, Certis Oncology Solutions
Consulting Fees: Agios, Blueprint Medicines, Daiichi Sankyo, Eisai, EMD Serono, GlaxoSmithKline, Immune Design, Janssen, Lilly, Loxo, Nanocel, Novartis, Plexxikon
Contracted Research: BioAtla, Blueprint Medicines, Daiichi Sankyo, Decipher, Immune Design, Lilly, Novartis, Plexxikon, TRACON Pharma
Patents, Royalties, Other Intellectual Property: Companion Diagnostic for CDK4 inhibitors, Methods of Treating Metastatic Sarcoma Using Talimogene Laherparepvec (T-Vec) and Pembrolizumab Combination Therapy
Silvia Stacchiotti, MD
Medical Oncologist
Adult Mesenchymal and Rare Tumor Medical Treatment Unit
Cancer Medicine Department
Fondazione IRCCS Instituto Nazionale Tumori
Milan, Italy
Advisory Board: Adaptimmune, Bayer, Daiichi Sankyo, Deciphera, Eli Lilly, Epizyme, lmmunedesign, Karyopharm, Maxivax, PharmaMar
Consulting Fees: Bavarian
Honoraria: Eli Lilly, PharmaMar, Takeda
Contracted Research (Institutional financial interests): Advenchen, Amgen, Bayer, Blueprint, Daiichi Sankyo, Epizyme, Karyopharm, Lilly, Novartis, PharmaMar, Pfizer
Michiel van de Sande, MD, PhD
Orthopedic Surgeon
Leiden University Medical Center
Leiden, The Netherlands
Dr. van de Sande has no relationship reported.
Andrew J. Wagner, MD, PhD
Medical Director, Adult Ambulatory Oncology
Associate Chief Medical Officer
Center for Sarcoma and Bone Oncology
Dana-Farber Cancer Institute
Boston, Massachusetts
Honoraria: Novartis
Consulting Fees: Daiichi Sankyo, Five Prime Therapeutics, Lilly, Loxo
Contracted Research: AADi, Celldex, Daiichi Sankyo, Karyopharm Therapeutics, Lilly, Plexxikon
Reviewers/Content Planners/Authors:
- Rob Braun has nothing to disclose.
- Ann Early has nothing to disclose.
- Jessica McGrory has nothing to disclose.
- William A. Mencia, MD has nothing to disclose.
Learning Objectives
The goal of this activity is to enable effective collaboration and communication between the members of the professional teams who care for patients with Tenosynovial Giant Cell Tumor (TGCT). After participating in this educational activity, participants should be better able to:
- Describe the correlation between TGCT pathophysiology and the efficacy of emerging treatments in managing the disease
- Formulate treatment strategies that include pharmacologic alternatives in patients with TGCT who may not benefit from surgery
- Identify potential strategies for monitoring and managing adverse events related with emerging pharmacologic therapies
Target Audience
This activity is designed to meet the educational needs of oncologists, surgical oncologists, orthopedic surgeons; oncology and orthopedic nurses, nurse practitioners, and physician assistants; and rheumatologists, rheumatology nurse practitioners, physician assistants; and other members of the interprofessional team who are involved in the management of patients with TGCT.
Accreditation and Credit Designation Statements
Global Learning Collaborative is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
Global Learning Collaborative designates this enduring material for a maximum of .25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
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Prova Education's methodology demonstrates a commitment to continuing medical education and the innovative assessment of its effects. Our goal is clear—to develop and deliver the very best education in the most impactful manner and to verify its results with progressive outcomes research.
Commercial Support
This activity is supported by an independent educational grant from Daiichi Sankyo.
The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and Prova Education. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients' conditions and possible contraindications or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of Prova Education you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.
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South Africa open source development company Shorewall wins logo competition
A logo design by South African Gareth Davies has won the Shorewall logo design competition. Davies works at SA open source development company Thusa.
Thusa makes extensive use of the open source firewall tool, Shorewall, in its Vulani server product which is due to be launched in South Africa in February 2009.
Thusa MD Warwick Chapman says that "in addition to contracting the services of Shorewall developers from time to time, Thusa felt it should allocate some time to designer Gareth Davies to have a crack at the Shorewall logo design competition."
Davies submitted four designs, eventually winning the competition with his third design. Thusa will be launching Vulani in South Africa next month following three years of active development and five years of research and development.


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Companies are scored on items like transparency, executive compensation, employee relations, and management structure.
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text: Gecko, Plaza Blanca, Abiquiu Photo of the DayGSPJuly 14, 2019 Leave a comment Gecko Lizard, Plaza Blanca, Abiquiu. I've not seen a gecko here before so it was a pleasant surprise when we spotted him. He was quite a poser and scurried around to a few locations alighting on the top of rocks for his closeup. Thanks for looking. G


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Spiderwick Chronicles, The
Movie: The Spiderwick Chronicles is set in the world built by writers Holly Black and Tony DiTerlizzi; a fantasy world full of all the creatures one would expect of a children's series but little of the free flowing magic we've seen in the Harry Potter releases. Without too many spoilers, I'll try to provide you with an overview of what to expect and why you should have this one on your short list regardless of your age, summing it up at the end. The most logical comparisons a critic could make would, on the surface at least, be the various Harry Potter effects of recent years but frankly, outside of passing similarities that derive from genre wide concepts, I don't think most of them I've read were overly thought out. Suffice it to say, Spiderwick stands on its own two feet and you can enjoy both series quite independent of each other with little room for saying either is better given they are not truly much alike so here goes!
The story starts out with the Grace family moving out of expensive New York City into a rural community more conducive to their financial straits given a recent divorce. Led by mother Helen (Mary Louise Parker), the three children, uppity Mallory (Sarah Bolger), passive Simon (Freddie Highmore), and disgruntled Jared (also Freddie Highmore) have different takes on the events that have led them here, moving into a large family estate tentatively owned by an aunt in a mental institution. Almost immediately upon placing their belongings inside the house, the children are fighting over missing items, setting the stage for what will happen to them. Jared is greatly upset at his father's leaving, blaming his mother in the way that children do, checking out forbidden parts of the house to find a mysterious book in a locked chest. Kids have a great way of getting into things and Jared is no different, reading the book despite a dire warning about the contents (truth be told, telling anyone not to touch the forbidden fruit of knowledge usually results in them wanting it all the more).
Jared soon studies the secrets of the book as written down by Arthur Spiderwick (David Strathairn), the father of the institutionalized aunt Lucinda, figuring out that his own observations support the realities contained within. He meets an assortment of characters along the way, including Thimbletack (Martin Short) and hobgoblin Hogsqueal (Seth Rogen), but doesn't get thrown into the dangerous aspect of his newfound knowledge until his brother ventures out beyond the house's protective barrier. It seems that the wealth of secrets that Arthur so studiously wrote down have a lot of value to the local baddy, an ogre by the name of Mulgarath (Nick Nolte) and his goblin minions. They will do anything to get hold of the book, including dragging Simon to their lair as the twin looks like Jared enough to fool the dark forces. The rest of the story deals with Jared and his family fending off the evil forces, knowing that if they fail or agree to terms with them; their fates are sealed. Unlike the convenient magic's of the Potter tales, the Grace's must rely on age old spells and Jared's knowledge gleamed from the book itself, presenting enough twists & turns to keep even the most jaded adult viewer interested (and younger audiences fascinated).
The believable performances added to the fun factor here as did the writing with the admittedly handsome special effects helping to create the fascinating world of the books rather than supplant the rest of the movie as so many of these flicks seem to do (ala Potter). The way the kids are intelligent and three dimensional make them better role models just as the realities of divorce and emotional pain were better handled here than I expected. Granted, there were still some gaping plot holes that could have been addressed better (without spoiling it, the judicious use of tomato juice from behind the protective shield comes to mind) and the blending of the special effects inside the two were not as realistic as the use in the forests or around the house, but the total experience sure made me want to get copies of the original books and watch a sequel so I rated this one as Highly Recommended.
Picture: The Spiderwick Chronicles was presented in a very appealing 2.35:1 widescreen color as shot by director Mark Waters and offered up in the AVC codec and toping 30 Mbps in the video bitrate much of the time. The flesh tones were accurate, the CGI effects extremely well handled by ILM, and the detail of the 1080p resolution exceptionally fetching on the eyes. The minimal noise in a few areas of the flick were hardly noticed until I was watching it a second time specifically for review, and the blacks were truly black with the kind of presentation I wish higher budget releases would embrace more often. The blending of the CGI and human elements was among the best I've seen from the company and certainly added some value to show off mid to high end home theaters. I saw no blocking or aliasing either time I watched it and as those who watched it with me suggested, there is considerable evidence that the picture was superior to other genre releases, including several of the Potter flicks though it was not perfect by any means.
Sound: The audio was presented in a range of usual choices with the primary track coming out in 5.1 Dolby TrueHD (5.1 Dolby Digital Spanish & French tracks also available) using a 48 kHz output and the variable bitrate often exceeding 4 Mbps. My experience with variable bitrate audio in this format is minimal but I can safely state that the audio really worked for me in assisting the visuals to make the world complete. The vocals were all placed nicely and clearly understood, the special effects superior, and the score fabulously detailed with a lot of use of the entire surround stage. The bass boomed in the right spots and the high ends were catered to quite well, the mixing top notch compared to some of the other fantasy titles out there. I did happen to notice a couple of minor quirks with synch but they were rare and unless I point them out, you probably will never notice them yourselves. For those who care, there were also subtitles in English, French, Spanish, and Portuguese. In all then, the technical aspects were well done!
Extras: So many blu-ray titles have been bare bones of late that I really appreciate it when a company steps up to the plate as Paramount is known to do. In this case, the extras almost outweighed the feature itself in terms of entertainment value, requiring me to take a lot longer to finish the complete review but giving me additional insight as well. The first extra on the disc was a 7:04 minute long clip called Spiderwick: It's All True! The feature was mastered in MPEG-2 but had a HD bitrate for those that care; the show allowing the director to introduce some of the main characters. This was followed by the 6:44 minute long It's A Spiderwick World where the original authors gave a head's up on the origin of the stories they wrote, providing the background for the modern day fable that led to the movie. Then came the extensive Arthur Spiderwick's Field Guide that essentially combined pages from the artistic book with clips from the movie (in high definition) to outline the characters. There is an "in-movie" version of this as well to give you a look at the creatures as they appear in the flick too but I doubt many will need it since they are written so straightforward and commented on at length. Then came the Meet the Clan extra lasting 15:54 minutes; detailing the human characters and the actors that play them, a self explanatory 20:53 minute long Making Spiderwick, a 14:23 minute long The Magic of Spiderwick that dealt with the special effects (mainly the animated characters), a quick 1:51 minute long comment from the director with "A Final Word of Advice!", an 8:14 minute selection of deleted scenes (several of which added something to the understanding of the movie's characters), and some theatrical & television trailers for the movie. I liked that the content here was presented in high definition (albeit not given as great a mastering job) but the volume of quality material alone was nicely done.
Final Thoughts: The Spiderwick Chronicles was full of the magic and wonder that great children movies often have, balancing out the roller coaster aspects of the action portions with the thoughtful exposition parts that fleshed out the movie for me as an adult. The books cover much of the material in greater depth and I have heard that some fans wanted it to be more true to the written series but the mark of a successful movie like this is often that it serves both sides of the coin, making most people happy. That said, my nonexistent exposure to the books limits my direct observations to compare them but this was very entertaining for me and some friends, the kind that is based in a rich tradition of folklore and likely to win the series a wider audience as it deserves. Perhaps a sequel will allow the producers to expand upon some aspects of the series or even go into all new territory but I look forward to seeing what comes next if this one is the guide to how the material will be treated.
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In November 2019, all the old Adobe licenses expire. This applies to, for example, licenses for Adobe Creative Cloud Complete and Adobe Acrobat CC.
If you have an older license that expires in November 2019, you will need to obtain a new license if you want to continue using the Adobe software. Below you will find instructions for this. Please note that you may do well with the alternative software for which we are already licensed, please see the tip at the bottom of this page.
If you need access to Adobe software, please follow these steps:
email@example.com (i.e. your own Lucat ID directly followed by
@lu.se) as username and you will be sent to LU's login page.
If you have access to all the software, be a little careful about how many you choose to install. Together, the software takes up a lot of space (130 GB or more) on your computer!
Please note that we have access to a number of software that are good substitutes for some of Adobe's software. We already have licenses for this software for all students and employees, and they therefore cost nothing extra. They are either already installed on your computer, or are available for installation through Software Center or AppsAnywhere.


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(CBS News) The rise of social media is one of the reasons why women are renting dresses, according to an online clothing rental firm executive.
"People are renting statement dresses, one shoulder, hot pink, that they're only going to wear once, have everyone give them tons of compliments and then they don't need to wear it again," Rent the Dress co-founder Jennifer Fleiss said Tuesday on "CBS This Morning." "And especially with things like Facebook, where everyone really is their own celebrity these days, women constantly need new things."
After less than three years in business, her business Rent the Runway has 2.5 million members, and offers 150 top designers' dresses and accessories.
Fleiss, a Yale and Harvard graduate, discussed what her company offers and how she and her co-founder Jennifer Hyman make the business work. Watch all that and more in the video above.


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New Concept Cars – Luxury and Smart?
It seems as though car designers are having a secret competition these days to come up with the most outrageous car designs. In an attempt to outdo each other and attract the masses, auto manufacturers are crafting some pretty funky looking vehicles. A few years ago the boxy look was all the rage, just ask Scion and Kia. Nissan took this idea and tweaked it a bit eventually releasing the oddly shaped Cube, which despite its name is more rounded than square. Honda went back to the drawing board and successfully incorporated the shape of an aircraft nose cone into the new Insight and Fit model designs. At Ford, the Flex designers appear to have been influenced by a package of graham crackers while the Ford Fiesta is obviously patterned after a June bug.
Tiny Cars Are Chic
With fuel prices skyrocketing it is no surprise that micro mini cars are now back in vogue. Gone are the days of big, flashy, urban assault vehicles. The rich, famous and ultra-cool are turning their attention to leaner and greener means of transportation. Heck even Jennifer Lopez is hawking the itty bitty Fiat 500, which will surely make this vehicle more popular with the urban crowd. As well, hipsters who can't get the keys to their parent's Buick LeSabre would be thrilled to be seen climbing out of stylish Mini Coopers, ironically of course.
Weird Is In
With this trend toward small and a new desire for the weird the question is what will be the next strange thing to roll off the assembly line? Perhaps designers could combine forces and blend not only different model designs but signature brand styling to make something completely unique. This author suggests an intersection of the world's most desirable vehicle, the Aston Martin with the world's tiniest and most efficient vehicle, the Smart Car. This cross-pollination would yield the very first luxury-sport-economy car and could be deemed the Smart-Ast.
The Perfect Combination
Similar to the notion of lobster corn dogs or Gucci baby diapers the Smart-Ast combination of chic and practical could be a huge success. No doubt it would appeal to suave sophisticates as well as nerdy geniuses around the globe. It probably would not be as fast as other Aston Martin models but who needs all those speeding tickets anyway? Considering only half of the vehicle would be comprised of Aston Martin parts the price point could be affordable for most. Just think of how much fun it would be to zip around town in a new Smart-Astturning heads as you pass by all the local car dealerships. You might even feel inspired to say something snide to those who ask about your interesting vehicle because, well, it is a Smart-Ast after all.
Windy Reigns, Author – Online Advertising


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'A Tavola' is an Italian phrase commonly used to say 'Come eat, your meal is ready!'. More literally 'a tavola' means 'a table' in Italian.
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Hugh Hefner's former "number one" girlfriend Holly Madison has admitted she was "freaked out and ashamed" after taking part in group sex sessions at the Playboy Mansion, and was so traumatised by her time at the celeb-packed pad that she developed a stammer.
The 37-year-old was Hef 's main partner for six years, but claimed that behind the glitz and glamour, the late publisher was a "cruelly manipulative" man who stripped her of her self-worth and offered her "thigh-opening" drugs.
"The sexy fairytale Hef would have you believe in was a bedazzled, twisted, toxic prison. And I know that because I spent six years as Girlfriend Number One to a man old enough to be my grandfather," said Holly, who was just 21 when she got with Hef in 2001.
"How could I justify such a thing? 'I'm here for adventure, a once-in-a-lifetime experience. I'm here as a stepping-stone to something else,' I told myself. And then perhaps the biggest illusion of all: 'I'm here for love.'"
In her 2015 biography, Down the Rabbit Hole, the blonde Girls Next Door star described how she first met Hef after scoring an invite to a Playboy party during whilst working as a busty waitress at Hooters in LA.
Having moved from Oregon to study at college and make it as an actress, she hoped the invite could at least score her an audition for the magazine.
The dress-code specified "sleepwear", so she spent what little money she had on a black corset, garter belt, stockings and a short silk robe, and soon found herself partying alongside the likes of Cameron Diaz, Jim Carrey and Leonardo DiCaprio.
However, she wrote that the host was slumped in a corner, leading Holly to wonder if he was "senile". And when she introduced herself, she scored a simple "nice to meet you darling," before he moved on to the next person.
The party invites kept coming though, and a year later she was a regular. Already dreaming about what it would be like to live in the mansion full-time, Holly said she couldn't understand why non of Hef's girlfriends looked pleased to be there.
She wrote: "His harem of girlfriends would trickle down to take their seats next to Hef at the dining table. I could never understand their lack of enthusiasm. Initially, I assumed they were spoiled, jaded, or just not a good fit in Hef's world. This may sound naïve, but I didn't immediately realise that they were actually required to sleep with him."
With the lease on her apartment about to end and her acting career still a non-starter, she decided that becoming a "girlfriend" could be the answer.
She got her big break when Hef invited her to a club night with six other women, however despite the glamour of their all-expenses paid VIP area, she descibed her companions as looking "vacant".
Then she claims Hef held out his hand and offered her sedative pills called Quaaludes, explaining they used to call them "thigh-openers" in the Seventies.
She declined, but on the car journey back, one of the girls warned her they were all expected to join Hef in bed. Reluctant to relive what happened next in detail, Holly admitted she was drunk and woke up the next morning feeling "freaked out and ashamed".
But she was desperate for somewhere to live, and despite what had happened, the next morning she asked Hef to move in.
It soon became clear that life at the mansion was very different to how she'd imagined.
The grand staircase was covered in pee stains from his nine dogs, and there was a strict routine, with the girls required to attend club nights on Wednesday and Friday, followed by a buffet dinner and movie night on Saturday and a pool party on Sunday. When they did get time off, the girlfriends had to be back at the mansion by 9pm.
The worst part, according to the reality star, was the way Hef tried to turn the girls against each other to create the impression that he was being "fought over".
He also berrated them, ordering Holly not to wear red lipstick again because it made her look, "old, hard and cheap."
Things got so bad that she developed a stammer, but that only endeared her to Hef even more and in less than 12 months she was promoted to the role of his main girlfriend.
So what did that involve? Moving into his room and having him say, "I love you." That was it.
Meanwhile, the situation with the other girls was spiralling. Holly claimed drug use was rife, and that one even asked her if she'd be interested in earning extra money as an escort.
Nonetheless, after six long years, she'd convinced herself she was in love and ready to settle down, although at 70 years of age, Hef was by then infertile.
And after a series of subsequent bust-ups, she decided the time had come to make her escape.


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Cedarcom hopes to open a dialogue with customers and readers on telecom issues in Lebanon on this blog as we continue to defend the rights and interests of both end-users and private operators in Lebanon.
We will keep you updated on developments in the telecom sector and our push for proper legislation and free market competition as well as our latest product and service offerings.
Over the past 15 years, Cedarcom's main goal has been to position Lebanon as the region's Internet hub by calling for fair competition in the telecom sector, delivering state-of-the-art data and inter-branching solutions to residential and corporate sectors, and campaigning for fast Internet access.
Cedarcom also plays a groundbreaking role in the wireless broadband industry through its subsidiary, Mobi™, the mobile broadband Internet access network. Mobi™ gives consumers the freedom to enjoy broadband Internet while on the move. All you need is a USB Dongle, a notebook and a subscription.
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Divine Presence and Community: A Commentary on the Book of Leviticus
Wm. B. Eerdmans Publishing, 1997 - Religion - 163 pages
This commentary by Frank Gorman shows how Leviticus, though focusing largely on matters associated with the Levitical priesthood, is also important to laypeople. Gorman addressed the question of Israelite identity and what it means to be the people of God. Through a careful application of exegesis and exposition, he shows that Leviticus is, foremost, a call to holiness, a weaving together of ritual and ethical issues to provide the community with a means for enacting and actualizing the covenant relationship.
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And worship Jesus with the cd festival of light you will truly draw yourself with him within into his Devine presence and will of God!
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Page vii - Christians — persons who affirm the witness of the New Testament concerning Jesus Christ. For Christians, the Bible is one scripture containing the Old and New Testaments. For this reason, a commentary on the Old Testament may not ignore the second part of the canon, namely, the New Testament. Since its beginning, the Church has recognized a special relationship between the two Testaments. But the precise character of this bond has been difficult to define. Thousands of books and articles have...
Page ix - God, the authors of the Old Testament knew what life is like on the edge of existence. They addressed themselves to everyday people who often faced more than everyday problems. Refusing to limit God to the "spiritual," they portrayed him as one who heard and knew the cries of people in pain (see Exod.
Page viii - Scriptures, the biblical interpreter must take care lest he "christianize" these Scriptures. Authors writing in this commentary will, no doubt, hold varied views concerning how the Old Testament relates to the New. No attempt has been made to dictate one viewpoint in this matter. With the whole Church, we are convinced that the relationship between the two Testaments is real and substantial. But we recognize also the diversity of opinions among Christian scholars when they attempt to articulate fully...
Page vii - This commentary series is written by front-rank scholars who treasure the life of faith. Addressed to ministers and Christian educators, the International Theological Commentary moves beyond the usual critical-historical approach to the Bible and offers a theological interpretation of the Hebrew text. Thus, engaging larger textual units of the biblical writings, the authors of these volumes assist the reader in the appreciation of the theology underlying the text as well as its place in the thought...
Page viii - Church is not of one mind in expressing the "how" of this relationship. The authors of this commentary share a developing consensus that any serious explanation of the Old Testament's relationship to the New will uphold the integrity of the Old Testament. Even though Christianity is rooted in the soil of the Hebrew Scriptures, the biblical interpreter must take care lest he "christianize
Page ix - By the end of this century, Christians in these areas will outnumber those who live in the West. In our age, especially, a commentary on the Bible must transcend the parochialism of Western civilization and be sensitive to issues that are the special problems of persons who live outside of the "Christian...
Page ix - ... context of firstcentury Judaism. Further, Jesus himself was Jewish, as were the first Christians. It is to be expected, therefore, that Jewish and Christian interpretations of the Hebrew Bible will reveal similarities and disparities. Such is the case. The authors of the International Theological Commentary will refer to the various Jewish traditions that they consider important for an appreciation of the Old Testament text. Such references will enrich our understanding of certain biblical passages...
Page ii - Is Savior: Faith in National Crisis by SH Widyapranawa Isaiah 40-55: Servant Theology by George AF Knight Isaiah 56-66: The New Israel by George AF Knight Jeremiah 1-25: To Pluck Up, To Tear Down by Walter Brueggemann Jeremiah 26-52: To Build, To Plant by Walter Rnieggemann Ezekicl: A New Heart by Bruce Vawter and Leslie J.
Page vii - ... to ministers and Christian educators, the International Theological Commentary moves beyond the usual criticalhistorical approach to the Bible and offers a theological interpretation of the Hebrew text. The authors of these volumes, therefore, engaging larger textual units of the biblical writings, assist the reader in the appreciation of the theology underlying the text as well as its place in the thought of the Hebrew Scriptures. But more, since the Bible is the book of the believing community,...
Page vii - Arising out of changing, unsettled times, this Scripture speaks with an authentic voice to our own troubled world. It witnesses to God's ongoing purpose and to his caring presence in the universe without ignoring those experiences of life that cause one to question his existence and love. This commentary series is written by front-rank scholars who treasure the life of faith.


text: Obanak is an Oni warlord active in the Wushanko Isles. During the Tetsu-Oni story voyage in Player-owned ports, he is discovered to be terrorising Ai Jei in search of gunpowder. Sojobo and Shanao then set out to stop him, and are eventually successful in defeating him. He is later discovered to have been aided in his attack by a purist known as Benkei in exchange for weapons, which included tetsu oni clubs.


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Searching for Convivencia with Nathalie Handal
Sep 17th, 2017
On a subway ride, my gaze falls upon a poem on the wall that begins with, "All stars lead to this city."Next to the poem, which is called "Lady Liberty," stands an illustration of a woman with sunglasses that reflect the Statue of Liberty. To encounter a poem like this, unexpectedly, provides a momentary sense of peace for me and other commuters squeezed into a packed subway car. ..
1968, meet 1932: Inside the Columbia Protests of April 1932
October 27th, 2017
As activists attempt to place a symbolic gag on the Alma Mater statue, they are attacked by members of a rival group, who grab the black cloth from their hands and drag them down Low Steps. Two camps have formed on opposite sides of campus, representing activists on strike and supporters of the administration. Clergyman and alumnus Eliot White rallies the activists against their adversaries. "You will probably find expert fighters in this crowd, but you must oppose them," he yells. "Our ancestors died for free speech, and it is up to you to defend it."..
Trying Not To Forget
October 27th, 2017
Somehow, she never looks any older. Every time I come to visit, once or twice a year, she greets me at the door. She almost always wears a red sweater, reminding my father and me that "red is her color." As soon as I entered the door to her home in St. Louis this winter break, we eased back into a routine with conversations last spoken. Talk, food, talking after food, hands resting on the tablecloth...