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The Difference Between Following a Template and Personal Coaching
A really well designed training template may get you the results you want, there are inherent some flaws in following a template though. How can personal fitness training be a better fit for you?
That Instagram fitness person you follow finally did it, they put out a program that you can follow to get you the awesome results they seem to have the secrets to. If this truly was a magic program that did just that, are there still some greater advantages to hiring a personal trainer?
Should You Follow a Template?
A really well designed popular template may have some advantages. If it has been around long enough to circle the internet and people track and post the results that they get, you have a really large sample size to tell you whether or not the program works!
Let's look at some of the advantages to running a program template:
- You pay for the template once and you're able to reuse it over and over again.
- A good template has been met with frequent questions by its users that have likely been answered somewhere and given to you to help you out.
- You have a repeatable program that will provide you with a consistent result.
- If you're not getting what you want in one area, hopefully there is some instruction provided by the writer on how to individualize the template without making drastic changes.
- Templates have usually been programmed around a specific goal so there is a good base for decision making.
Now there are a few limits to following a template, its not a controlled study:
- You won't be able to find out how experienced these people are with exercising, beginners progress differently than intermediates and advanced lifters.
- You won't know how strict of a diet program the people who followed the template were on.
- You won't know if they made any personal modifications to the program that could completely change the outcome!
The most obvious drawback to following a template is that you won't have anyone there with you to coach your form. You'll also miss out on the accountability of having someone there with you expecting you to show up, work hard and try to get better each day at something.
You're ready
Let's create an organized plan that holistically achieves your goals.
How to Know if A Template is Right for You
You should be able to follow a template if:
- You're self reliant and have no problem working out on your own.
- You have proficient experience executing most basic exercise patterns.
- You have some experience and know how to modify a program to fit your needs.
If you do not meet those criteria than a template may not be right for you. I've followed some in the past and experienced some good results from a few. I generally like to write my own programs because I like the flexibility it gives me but, I also like to see how other people work through solving the same problems.
If you'd like help with your program, or want to go ahead and hire a trainer fill out the contact form!


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If you drive a Honda near Middletown or Eatontown, NJ, need to order new parts for your new Honda Accord, then take advantage of the order form here on our easy-to-use website or visit our dealership in person. Install components that have been manufactured specifically for your automobile. Aftermarket products don't always fit correctly. When you install components that were not made by Honda you run the risk of damaging support systems due to ill fit. Help ensure your car runs as smoothly as the day you bought it. You also contribute to maintaining your Honda's resale value. Don't jeopardize your safety on the road, only use genuine Honda parts on your Civic. Our parts department is here on-site to answer any questions you might have about a particular part or installation. Shop DCH Kay Honda today.
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"Kamal Haasan's tongue should be cut-off", says TN Minister
Chennai, May 13: Kamal Haasan has stirred a hornet's nest by saying that the first extremist in Independent India was a Hindu, referring to Nathuram Godse.
The BJP accused Kamal Haasan, the leader of Makkal Needhi Maiam (MNM), of trying to create a rift among two groups in the name of religion.
Kamal Haasan, the leader of Makkal Needhi Maiam (MNM), a violation of the Model Code of Conduct, the BJP said the actor-politician was trying to create a rift among two groups in the name of religion.
Tamil Nadu Bharatiya Janata Party (BJP) president Tamilisai Soundararajan said "Uttering nonsense" on a sensitive subject amounts to violating the poll code of conduct.
Now, Tamil Nadu Minister K.T. Rajendra Balaji has reportedly said that Haasan's should be cut off.
"Kamal Haasan's tongue should be cut off for his remarks on Hindu terror. He made these remarks to gain votes of minorities. We can't blame entire community for act of one individual. The Election Commission should take action against the actor and ban his party," Balaji said as per ANI report.
KT Rajenthra Bhalaji is incumbent member of the Tamil Nadu Legislative Assembly from the Sivakasi constituency. he is an AIADMK leader.
[The first terrorist was a Hindu, his name was Nathuram Godse: Kamal Haasan]
Meanwhile, the Shiv Sena slammed Kamal Hassan's comments on Nathuram Godse, saying his theory is a "flop story" and a "useless statement".
"Kamal Hassan is a very good actor. But his theory is a flop story. People do not have sympathy for Godse. Hindus will not tolerate it when their religion is linked with terrorism. There is no difference between Kamal Haasan and Digvijaya Singh. It is a useless statement just to gain publicity," Shiv Sena's Sanjay Raut said.
Haasan while while campaigning in the town of Aravakurichi in Tamil Nadu's Karur district on Sunday night said in Tamil, ""I am not saying this because this is a Muslim-dominated area, but I am saying this before a statue of Gandhi. Independent India's first extremist (theevravaadi) was a Hindu, his name is Nathuram Godse. There it starts."


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Comparative lesion sequencing provides insights into tumor evolution
Contributed by Bert Vogelstein, December 31, 2007 (received for review December 11, 2007)
We show that the times separating the birth of benign, invasive, and metastatic tumor cells can be determined by analysis of the mutations they have in common. When combined with prior clinical observations, these analyses suggest the following general conclusions about colorectal tumorigenesis: (i) It takes ≈17 years for a large benign tumor to evolve into an advanced cancer but <2 years for cells within that cancer to acquire the ability to metastasize; (ii) it requires few, if any, selective events to transform a highly invasive cancer cell into one with the capacity to metastasize; (iii) the process of cell culture ex vivo does not introduce new clonal mutations into colorectal tumor cell populations; and (iv) the rates at which point mutations develop in advanced cancers are similar to those of normal cells. These results have important implications for understanding human tumor pathogenesis, particularly those associated with metastasis.
Colorectal tumorigenesis proceeds through well defined clinical stages associated with characteristic mutations (1, 2) (Fig. 1). The process is initiated when a single colorectal epithelial cell acquires a mutation in a gene inactivating the APC/β-catenin pathway (1). Mutations that constitutively activate the KRAS/BRAF pathway are associated with the growth of a small adenoma to clinically significant size (>1 cm in diameter) (3). Subsequent waves of clonal expansion driven by mutations in genes controlling the TGF-β (4, 5), PIK3CA (6), TP53 (7), and other pathways are responsible for the transition from a benign tumor (adenoma) to a malignant tumor (carcinoma). The only difference between a carcinoma and an adenoma is the ability of the former to invade the tissues underlying the colorectal epithelium. Some tumors eventually acquire the ability to migrate and seed other organs (metastasis) (8). Colorectal tumors can usually be cured by surgical excision at any stage before this last one, i.e., before metastasis to distant sites such as the liver (9).
Understanding the basic features of this evolutionary process has obvious and important implications for both scientific and medical research. But many questions remain. For example, how long does it take for a particular neoplastic cell to acquire the genetic events required for each sequential step in this progression? This question has heretofore been impossible to address in individual patients, although relevant information about bulk tumors, rather than cells, has been obtained through clinical and radiographic studies (10–12). We here describe an approach that can answer this and related questions.
Large-scale sequencing of the vast majority of protein-coding genes in human tumors has recently become possible and was applied to study the genomes of breast and colorectal cancers (13, 14). In the current study, we investigated whether the mutations discovered in the colorectal cancers evaluated in Wood et al. (14) were found in other neoplastic lesions from the same patients, an approach we call "comparative lesion sequencing." We show that the sequencing data, when analyzed quantitatively, can be used to determine the time intervals required for development of the cells responsible for any two sequential clonal expansions. We were particularly interested in the expansion associated with metastasis. This final expansion is the least well understood at the biochemical and physiologic levels, even though it is responsible for virtually all deaths from the disease.
Point Mutation Rates and Growth Kinetics of Colorectal Cancers.
Although knowledge of the precise mutation rate and tumor growth rates of these lesions are not required to make conclusions from comparative lesion sequencing, estimates of these parameters can inform their interpretation. An estimate of the point mutation rate in these tumors can be made on the basis of the results reported in ref. 14, wherein 847 nonsynonymous mutations were detected among 304 million bp sequenced at high quality. All of these mutations were somatic, i.e., not present in the germ line. Most of the lesions evaluated in ref. 14 were liver metastases, and all were mismatch-repair proficient. To convert the mutation prevalence data in ref. 14 to a mutation rate, it is necessary to know the number of divisions that the cancer cell had undergone. The most reliable way to measure cell-division time in human tumors is through the administration of DNA precursors such as BrdU to patients, followed by evaluation of BrdU incorporation plus DNA content by means of flow cytometry (15). This approach yields Tpot, defined as the time between cell divisions in the absence of cell death. Several hundred colorectal cancers have been evaluated by this method, with Tpot measured as ≈4 days (16–21). By using this figure for the cell division rate and the mutational data reported in ref. 14, the point mutation rate in colorectal cancers is estimated to be 4.6 × 10−10 mutations per base pair per generation. This rate is slightly less than that measured in various normal cell types [≈10 × 10−10 mutations per base pair per generation (22–25)]. Additional details about this estimate are provided in supporting information (SI) Methods .
Comparison of Mutations Before and After Cell Culture or Xenografting.
The samples used in ref. 14 were all derived from colorectal cancer cells that had been passaged for 6–12 months in vitro as cell lines or in nude mice as xenografts. Before initiating the current study of other lesions from the same patients, it was important to determine whether the mutations identified in the cultured or xenografted cells were actually present in the naturally occurring lesions before cellular expansion ex vivo. For this purpose, we analyzed 289 different mutations found in 18 cell lines or xenografts, each derived from a different patient. Five of these had been initiated and passaged in vitro, whereas the remaining 13 had been passaged as xenografts in nude mice. Two hundred eighty-seven of the 289 mutations (99.3%) found in the cell lines or xenografts were also found in the original tumors. The direct Sanger sequencing method we used in the experiments reported herein had a sensitivity of ≈25%, so that a heterozygous mutation present in <50% of the cells would not be observed (Fig. 2). These data therefore indicate that the point mutations found in colorectal cancer cell lines or xenografts only rarely arise during in vitro or in vivo experimental growth of cells after the tumors are excised from patients.
Comparison of Metastases with Primary Colorectal Cancers.
Paired samples of primary colorectal cancers and metastatic lesions from 10 patients were available for this study. Of the index lesions (Table 1), seven had been excised from the liver and three from mesenteric lymph nodes. We were able to evaluate an average of 28 mutations per lesion in the patients evaluated in the Discovery screen of ref. 14. The remaining index lesions had been studied only in the Validation screen, so only approximately five mutations per patient could be studied in these cases. In all, 233 somatic mutations identified in the index metastases were evaluated in the 10 cases. Of these, only seven [3.0%, 90% confidence interval (C.I.) 1.5–5.7%] were not found in the colorectal cancers from which the metastases arose (SI Table 2).
Comparisons of Different Metastatic Lesions.
In 11 of the 13 patients, we were able to examine at least one metastatic lesion different from the index lesion of the same patient. Of a total of 261 mutations evaluated, 255 (97.7%) were found in the 29 additional metastases studied (Table 1). This was the expected result, because the great majority of the mutations present in metastases were also present in the precursor advanced colorectal carcinoma, as noted above. What was more informative was the study of patients in whom mutations were identified in the metastasis but not in the precursor advanced carcinoma (henceforth denoted "metastasis-specific mutations"). Although there were only seven of these mutations identified, five of them were particularly informative because they could be assessed in other metastatic lesions from the same patients. In patient 5, both of the metastasis-specific mutations originally identified in the index liver metastasis were also identified in a mesenteric lymph node metastasis. In patient 7, three liver metastasis-specific mutations identified in the index metastasis were identified in a second, independent liver metastasis concurrently excised from the patient.
Comparison of Advanced Colorectal Carcinomas with Large Adenomas.
It is believed that colorectal carcinomas arise in preexisting, benign adenomas through the acquisition of additional genetic alterations (Fig. 1). In most cases, the adenomatous tissue is destroyed during carcinoma growth. However, in two of the cases studied here, large residual adenomas at the edges of the carcinomas were still present (Fig. 3). Paraffin-embedded sections of these lesions were carefully microdissected to separate adenomatous from carcinomatous elements and evaluated for 33 mutations known to be present in the carcinoma. Ten of the 33 mutations (30%) were not found in the adenomatous components (see SI Table 2). The differences between the fraction of mutations found in metastases but not their precursor advanced carcinomas and the fraction of mutations found in the advanced carcinomas but not in their large precursor adenomas were statistically significant (P < 0.001, two-group binomial test for equality of proportion).
Of the 10 mutations identified in advanced carcinomas but not large adenomas, 7 were in candidate cancer genes (CAN-genes) as defined in Wood et al. (14). This proportion is significantly different from the proportion of metastasis-specific mutations (14%) that were in CAN-genes (P < 0.001, two-group binomial test) or the proportion of mutations that were in CAN-genes among all genes with mutations (16%, P < 0.01, two-group binomial test). Two of the 10 mutations identified in carcinomas but not in their precursor adenomas were in TP53, consistent with prior data on the timing of TP53 mutations (26).
Quantification of the Level of Mutations in DNA.
The absence of a somatic mutation in a given DNA sample, as assessed by Sanger sequencing, simply means that the mutation was not present in >25% of the analyzed DNA template molecules (i.e., >50% of the cells in the case of heterozygous mutations). Mutations present in a smaller fraction can generally not be distinguished from the background in sequencing chromatograms. To determine whether the mutations were present in a smaller but still sizable fraction of the tumor cell population, we evaluated a subset of the DNA samples via BEAMing (beads, emulsions, amplifications, magnetics) assay (see SI Methods ) (27, 28). We performed 20 BEAMing assays in seven patients, focusing on those mutations that appeared to be present in late-stage lesions but not in an earlier-stage lesion of the same patient (e.g., present in metastasis but not in the advanced colorectal carcinoma). In 19 of these assays, no mutations were observed (examples in Fig. 4). Because the sensitivity of the BEAMing assays was ≈0.01%, we conclude that <1 in 2,500 cells in the precursor lesion contained any of these 19 mutations, thus suggesting that at least one major clonal expansion occurred between the two stages analyzed in each case.
Colorectal Cancer Evolution: Mathematical Assessment.
The data in Table 1 can be used to determine the relative timing of the birth of the founder cells (Fcells) that gave rise to the various tumor cell populations described above (Fig. 5). The basis for this analysis is that all somatic mutations present in clonal fashion in an adenoma (i.e., present in all cells of the tumor) must have been present in its cell of origin (its founder cell). These mutations accumulated during the life span of this founder cell and include those that occurred during the turnover of normal stem cells before the onset of tumorigenesis. As tumors progress, they accumulate additional mutations that become fixed in the founder cells of subsequent neoplastic states. The founder cell of the advanced carcinoma, for example, will harbor all of the mutations present in the precursor adenoma plus additional mutations that occurred in the interim. The length of this interim period can be estimated by measuring the number of additional mutations in the progressed lesion.
The founder cells of interest are (i) the one (FcellMet) that gave rise to the final clonal expansion resulting in the index metastasis; (ii) the last common ancestor (FcellACa) of the advanced carcinoma and FcellMet; and (iii) the last common ancestor (FcellLAd) of the large adenoma and FcellACa. The birth date (T) of a founder cell is defined as the age of the patient when the founder cell underwent its first division. As shown in the SI Methods , the interval (ΔTACa,Met) between the birth date of founder cells FcellMet and FcellACa can be approximated as where F ACa,Met is the fraction of the mutations in the metastasis that were not found in the advanced carcinoma (i.e., 1 − [number of mutations in advanced carcinoma/number of mutations in metastasis]). Similarly, the interval (ΔTLAd,ACa) between the birth dates TLAd and TACa of founder cells FcellACa and FcellLAd, respectively, can be approximated as where F LAd,ACa is the fraction of mutations in the advanced carcinoma that were not found in the large adenoma. Similar equations can be applied to any two lesions that represent the clonal expansions of two founder cells as long as one of the two founder cells is a direct descendent of the other.
Note that these equations are entirely independent of the actual mutation rates and cell division times (Tpot), which likely vary among different patients and cancers. They only require that the mutation rate and cell division times, whatever they are, are constant throughout each patient's life. The approximations in Eqs. 1 and 2 are accurate as long as the number of mutations with positive or negative effects upon growth is small compared with the number of neutral mutations. As detailed in SI Methods , this requirement is, in general, expected to be met. Mutations thereby act as a clock, providing information similar to that obtained through the use of sequence divergence to assess the relatedness of organisms or cells during evolution or development (29, 30).
Application to Individual Patients.
One of the major results of the current study is that FLAd,ACa is much greater than FACa,Met, meaning that it takes much longer for a large adenoma to evolve into an advanced carcinoma than for such a carcinoma to metastasize. Assumptions that limit the accuracy of the times determined through these equations are given in SI Methods . Their implementation can best be illustrated through their application to five patients in the current study in whom a minimum of 25 mutations could be evaluated (Table 1).
Patient 1 was 73 years old when she developed an advanced carcinoma of the ascending colon that was 4 cm in diameter and of stage T3N1M0 (T3 refers to the stage of the carcinoma, which, in this case, had grown completely through the muscularis propria; N1 indicates that cancer was found in at least one but less than four lymph nodes; M0 indicates that no distant metastases were evident at the time of surgery). Fifteen months later, a liver metastasis of 5 cm in diameter was found to have developed. All 47 mutations found in the metastasis were also found in the advanced carcinoma in the colon (FACa,Met = 0.0). Application of Eq. 1 indicated that the metastasis originated from a cell (FcellMet) whose birth occurred very soon after the birth of the cell (FcellACa) that founded the advanced carcinoma (C.I., 0–3.4 years).
Patient 3 was 83 years old when she developed an advanced carcinoma of the ascending colon that was 9 cm in diameter and of stage T4N2M1 (N2 indicates that cancers cells were found in more than three mesenteric lymph nodes). A residual adenoma that surrounded the carcinoma was identified at the time of surgery. A small (<1-cm diameter) mesenteric lymph node metastasis was found to contain 25 mutations that were subsequently evaluated in other lesions of this patient. Of these, 24 were found in the colorectal carcinoma (FACa,Met = 0.04). Application of Eq. 1 indicated that the advanced carcinoma founder cell was born 3.2 years (C.I., 0.4–7.1 years) before the lymph node metastasis founder cell was born. In contrast, evaluation of the same mutations in the large adenoma from which the carcinoma developed revealed an FLAd,ACa of 0.23. Application of Eq. 2 indicated that the large adenoma founder cell was born 17 years (C.I., 7.9–30.9 years) before the advanced carcinoma founder cell. In the ≈17 years between the birth of FcellLad and FcellACa, the tumor underwent waves of clonal expansion driven by mutations in TP53 and the other genes (SI Table 2) presumably required for invasion and further growth of this tumor. Once it acquired these capabilities, a cell (FcellMet) capable of lymph node metastasis appeared within a relatively short period.
Patient 5 was 72 years old when he developed an advanced carcinoma of the sigmoid colon that was 1.5 cm in diameter and of stage T3N2M1, accompanied by an 8.9-cm liver metastasis. Comparative lesion sequencing indicated that the metastasis founder cell FcellMet was born 2.8 years (C.I., 0.6–4.9 years) after the birth of the advanced carcinoma founder cell FcellACa. A large (1.3-cm) mesenteric lymph node metastasis and two smaller mesenteric lymph node metastases were also evaluated from this patient. The larger lymph node contained the same 50 mutations identified in the liver metastasis, including the two mutations not found in the primary colorectal carcinoma; the two smaller lymph nodes did not contain these two mutations. Thus, the 1.3-cm mesenteric lymph node metastasis and liver metastasis founder cells may have both been derived from a small population of cells within the carcinoma that had acquired metastatic capability. Alternatively, the liver metastasis could have originated from the large mesenteric lymph node metastasis. In this case, comparative lesion sequencing indicates that the liver metastasis founder cell must have been born soon after (0 years; C.I., 0.0–2.0 years) the birth of the of lymph node metastasis founder cell.
Patient 7 was 55 years old when she developed an advanced carcinoma of the ascending colon that was 3.5 cm in diameter and stage T3N1M0. Twenty months later, two metastases of 3.5- and 4-cm diameter were found in the liver. Comparative lesion sequencing of the 4-cm liver metastasis and the colorectal cancer indicated the metastasis founder cell was born 6.6 years after the carcinoma founder cell (C.I., 1.8–8.6 years). Two mesenteric lymph node metastases removed at the time of the initial surgery and the 3.5-cm liver metastasis noted above were also evaluated. Three metastasis-specific mutations were identified in both liver metastases but not in either nodal metastasis.
Patient 13 was 55 years old when he developed an advanced carcinoma of the ascending colon that was 2.5 cm in diameter and stage T3N1M1. A 7-cm metastasis in the right lobe of the liver and a metastasis in a mesenteric lymph node were removed at the time of surgery. Twenty-nine months after this resection, a new liver metastasis of 3.1-cm diameter was detected in the left lobe and completely excised. One year later, another metastasis in the liver, of diameter 3.5 cm, was identified. The metastases that were identified 29 and 41 months after the initial diagnosis both had 19 mutations that were not found in the advanced carcinoma or metastatic lesions excised at the initial surgery, with FACa,Met = 0.28. In contrast, all of the mutations identified in the metastatic lesions removed at the initial surgery were also present in the advanced carcinoma removed concurrently. We interpret this result in the following way. Chemotherapy consisting of irinotecan, leucovorin, and 5-FU administered in the 9 months after the initial surgery pruned most of the micrometatastic cells remaining in the liver. One of these cells was resistant to the chemotherapy and became the founder cell of the new metastasis and its later recurrence. The chemotherapy had induced many new mutations in this cell, consistent with the known mutagenicity of irinotecan and perhaps exacerbated by the 5-FU (31). Eq. 1 cannot be used to estimate the relative birth date of this cell because comparative lesion sequencing requires that the mutation rate be constant throughout the tumorigenic process (see SI Methods ). It is notable that this patient was the only one of the patients analyzed in depth in our study who had been treated with irinotecan before the development of a new metastatic lesion.
A Temporally Defined Model of Colorectal Cancer.
The data and approach used in the current study can be used to temporally model some of the key genetic events in colorectal tumorigenesis. As illustrated in Fig. 5, comparative lesion sequencing suggests that the average time interval between the birth of a large adenoma founder cell and the birth of an advanced carcinoma founder cell is 17 years (C.I., 10.9–26.5 years). However, the average interval between the birth of the advanced carcinoma founder cell and the liver metastasis founder cell is only 1.8 years (C.I., 0.9–3.1 years).
Information about the birth times of the founder cells giving rise to various neoplastic stages has not heretofore been available. However, our estimates of these values are consistent with clinical and radiological observations on bulk tumors. For example, the time between the appearance of small adenomas and the diagnosis of a carcinoma has been estimated at 20–25 years from studies of patients with familial adenomatous polyposis (11). Similarly, serial studies of sporadic colorectal tumor patients have indicated that the transition from large adenoma to carcinoma takes ≈15 years (11). Our estimates are also consistent with the long doubling times of tumors determined by serial radiologic studies or serial measurements of the CEA serum biomarker (10, 12, 32, 33). Such studies have indicated mean doubling times that are generally 2–4 months in metastases and much longer in adenomas and carcinomas.
Biological Implications.
Our findings suggest that virtually all of the mutations necessary for metastasis are already present in all of the cells of the antecedent carcinoma. These data are compatible with two distinct models. In model A, none of the carcinoma cells can give rise to a metastasis, but they are close to being able to do so; one or a few more genetic alterations are required. In model B, all of the carcinoma cells can give rise to metastasis; no more genetic alterations are required. Data derived from the current study, involving comparisons of different metastatic lesions from the same patients, are compatible with either model.
Model A.
If every cell in the cancer cell population were capable of giving rise to a metastasis, it is extremely unlikely that any two independent metastases would harbor an identical mutation not found in the carcinoma. However, as described in Results, we identified five metastasis-specific mutations that were each present in more than one metastasis from the same patient (patients 5 and 7). If the founder cells of one of these two metastases were not a direct descendent of the other, these data would support the idea that a small population of cells within the carcinoma had acquired additional alterations that endowed them with the capacity to metastasize. Such alterations could be the point mutations actually identified as metastasis-specific (SI Table 2) or any other heritable event [whole chromosome gains or losses, chromosome translocations or amplifications, or certain epigenetic changes (34)].
Model B.
General support for this model comes from the fact that there so few additional alterations identified in the metastases compared with the advanced carcinomas. The finding that mutations not found in the carcinoma were identified in two anatomically distinct metastases could be explained if the founder cells of the two metastases had both come through a bottleneck after they migrated from the primary colorectal carcinoma. In Patient 5, this could have occurred if the liver metastasis had developed from a cell within the mesenteric lymph node metastasis that contained the same mutations. In Patient 7, this could have occurred if both liver metastases' founder cells had developed in lymph node metastases that were not detected or excised.
The reason that progression of the large adenoma to advanced carcinoma takes so much longer than the progression of the latter to metastasis is presumably because many more mutations and clonal expansions are required (some of which are indicated in Fig. 5). Moreover, some of the genes responsible for the adenoma-to-carcinoma progression have been identified (SI Table 2 and Fig. 5). One reasonable interpretation of the data is that the capacity to invade through layers of the bowel wall without dying, thereby becoming an advanced colorectal cancer, is the most challenging step in the process that eventually leads to metastasis. Once that step occurs, few additional steps are required for metastasis to take off. The advent of large-scale cancer genome sequencing provides uniquely valuable biomarkers to study tumor evolution. The study of additional mutations and lesions using the approach described in this work could definitively answer a variety of long-standing questions about the basic nature of the metastatic process in humans (35–39).
Materials and Methods
DNA samples from tumor samples or their derived xenografts or cell lines were obtained and purified by using slight modifications of those described (13). Two hundred eighty-nine exons in which a mutation had been identified in an index lesion studied in refs. 13 or 14 were PCR-amplified in all other available DNA samples from the patient. DNA samples from xenografts, cell lines, and frozen tissues were amplified by using the primers described (14). New amplicons of smaller size were designed for the DNA purified from paraffin-embedded samples. When sequencing chromatograms were difficult to interpret in the DNA purified from tumor samples, we reevaluated the mutation in question either by cloning the PCR product and sequencing individual clones or by performing a BEAMing assay (27, 28). Additional, more detailed methods are described in SI Methods .
We thank D. H. Nguyen for preparing Fig. 5; J. Lutterbaugh and L. Kasturi for expert technical assistance; Y. He for advice about flow cytometry; and D. Shibata, D. Williams, and J. T. Vogelstein for critical comments. This work was supported by the Virginia and D. K. Ludwig Fund for Cancer Research, Public Health Service Grants CA43460, CA57345, CA62924, CA121113, CA116867, CA120237, CA127306, CA043703, CA62924, CA105090, and GM078986, and by a gift from the National Colon Cancer Research Alliance. N.B. was partially supported by a grant from the Bill and Melinda Gates Foundation through the Grand Challenges in Global Health Initiative.
- ‡‡To whom correspondence may be addressed. E-mail: vogelbe{at}jhmi.edu, josephe.willis{at}uhhospitals.org, or sxm10{at}cwru.edu
Author contributions: S.J. and W-d.C. contributed equally to this work; S.J., W.-d.C., V.E.V., K.W.K., B.V., and S.D.M. designed research; S.J., W.-d.C., F.D., and J.W. performed research; F.D., N.B., T.A., A.T., M.A.N., C.S., and J.W. contributed new reagents/analytic tools; S.J., W.-d.C., G.P., N.B., T.A., A.T., and M.A.N. analyzed data; and B.V. and S.D.M. wrote the paper.
Conflict of interest statement: Under separate licensing agreements between The Johns Hopkins University and Exact Sciences Corporation and Genzyme Corporation Oncology, V.E.V., K.W.K., and B.V are entitled to a share of royalty received by the University on sales of products described in this article/presentation. V.E.V., K.W.K., and B.V and the University own Genzyme Molecular Oncology stock, which is subject to certain restrictions under University policy. The terms of this arrangement are being managed by The Johns Hopkins University in accordance with its conflict of interest policies.
This article contains supporting information online at www.pnas.org/cgi/content/full/0712345105/DC1.
- © 2008 by The National Academy of Sciences of the USA
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Kick 'em when they're down
I see that the O is really going to rub Lincoln High School's nose in the drug thing. With Super Vicki busy selecting a moving company, a school board election on, and the school bureaucracy suddenly rudderless, the O will probably go on about it for weeks.
Drugs in our schools is a worthy topic, to be sure, but today's spin -- Lincoln kids are into harder drugs because they have money and are smart -- sounds like a humongous crock to me. Oh, and the reporters can't wait to get some kid at Grant to chime in: "'I'm sure there are drugs at every school, but Lincoln, they can afford the harder ones,' said Libby Watkins, a Grant High junior. 'They're really known as partyers.'"
Sheesh. Don't leave room in the trophy case for another Pulitzer out of that one. And it took six people to write it.
If this horrible incident had gone down at Jefferson, you'd never hear this outcry from our beloved daily. And if you did, you can bet someone would jump right up and say the "r" word. It's a lot easier to pick on Lincoln. And so, it appears, they will.


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DB42 – Brushless DC motor
BLDC motor with quiet running characteristics, high acceleration rates, a long service life and speeds of up to 14,000 rpm. By mounting a Nanotec encoder, this motor can be expanded into a high-performance servo motor for high speed ranges. For higher torques and a wider performance range Nanotec offers matching planetary gearboxes. Available in various lengths and versions.


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I have definitely played Virtual Pool before - we may even have had the same cracked version back in the '90s. I remember the graphics and the controls well. There's not really much to say about it - it's a great pool game for the time, with a really good feel. Everything behaves as it should, and I found myself cursing when I missed a shot in exactly the same way as I do when playing real pool. You know when you miss that it was your fault. There's no time pressure, no external factors, it's all just down to the fact that you aimed incorrectly or didn't use enough power. The controls are great, with the mouse responding beautifully as a cue and a satisfactory clack from the kissing balls. The ragtime music dittying away in the background gets a bit grating after a while, but it's easy enough to turn it off. Again, it would be much better playing against a real person, but otherwise I think this is a great game of pool, and one I'd be very happy to sit down with a mate and a couple of beers and while away the hours as Scott Joplin plays and cue ball spins across the baize.
Next up on the randometer is...(no more sports games please)...Moonshine Racers! Never heard of it. Apparently, it's an early '90s racing game where you have to deliver booze and avoid the cops. Could be fun.


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Now showing items 1-2 of 2
Promoting psychosocial well-being following stroke: study protocol for a randomized, controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-03)

Background: Stroke is a major public health threat globally. Psychosocial well-being may be affected following stroke. Depressive symptoms, anxiety, general psychological distress and social isolation are prevalent. Approximately one third report depressive symptoms and 20% report anxiety during the first months or years after the stroke. Psychosocial difficulties may impact significantly ...
Finding the way forward : the lived experience of people with stroke after participation in a complex psychosocial intervention
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-03-12)
Stroke patients' well-being is threatened after stroke. A psychosocial intervention was developed for Norwegian stroke patients living in the community. Eight individual sessions between people with stroke and a trained health care professional were conducted 1 to 6 months post-stroke with one group of participants and 6 to 12 months post-stroke with another group. Subsequently, 19 of these stroke ...


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Many CPA network, offer and advertiser owners oftentimes simply write off the fraud problem they know is ever-prevalent on their network or offer(s) simply because it's convenient. If they don't think about it too much, they won't worry about it … Continue reading
You're likely asking yourself what ScrubKit can do for you. No doubt you've heard of us at some point in your affiliate networking travels and endeavors the last few months. We're a revolutionary and trailblazing new fraud and risk management … Continue reading
While we don't get asked about it all the time, you can imagine that some people actually do approach us wondering if we could point them in the direction of another CPA fraud and risk management solution alternative to ScrubKit. … Continue reading


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9Wishes, Sun Moisturizer, SPF 50+ PA+++, 1.7 fl oz (50 ml)
Flash Deals are limited time, limited quantity promotions, so act fast! Limited to: 1 unit of 1 flash deal product per order. If you order more than one unit or re-order or order other flash deals, you will pay our regular low price. Flash Deals are ineligible from all other promotions.
9Wishes, Sun Moisturizer, SPF 50+ PA+++, 1.7 fl oz (50 ml)
- Expiration Date: June 2023
Shipping Weight:?0.09 kgSwitch to Imperial unitsShipping WeightThe Shipping Weight includes the product, protective packaging material and the actual shipping box. In addition, the Shipping Weight may be adjusted for the Dimensional Weight (e.g. length, width & height) of a package. It is important to note that certain types of products (e.g. glass containers, liquids, fragile, refrigerated or ice packed) will often require protective packaging material. As such, these products will reflect a higher Shipping Weight compared to the unprotected product.
- Product Code: WSH-95370
- UPC Code: 8809429953704
- Package Quantity: 1.7 fl oz
12.7 x 5.1 x 3.3 cm , 0.07 kgSwitch to Imperial units
Product Rank:
- Advanced Light-Weight UV Protection
Protect you skin from the sun with this light, long-lasting and advanced SPF50+ formula that absorbs quickly, leaving the skin feeling fresh without residue.
Intensive defense against UVA/UVB rays that cause sunburn, cell damage, dryness, roughness, and premature signs of aging such as fine lines.
Suggested Use
Apply evenly on face 15 minutes before sun exposure. Re-apply as often as needed.
Other Ingredients
Water, ethylhexyl methoxycinnamate, zinc oxide, homosalate, ethylhexyl salicylate, methylpropanediol, glycerin, bis-ethylhexyloxyphenol methoxyphenyl triazine, octocrylene, niacinamide, polysorbate 60, silica, cetearyl olivate, sorbitan olivate, cetearyl alcohol, beeswax, dimethicone, magnesium aluminum silicate, sorbitan sesquioleate, sodium hyaluronate, simmondsia chinensis (jojoba) seed oil, olea europaea (olive) fruit oil, butyrospermum parkii (shea butter), 1,2-hexanediol, pinus densiflora leaf extract, morus alba bark extract, camellia sinensis leaf extract, chrysanthemum indicum flower extract, rhus semialata gall extract, scutellaria baicalensis root extract, lonicera japonica (honeysuckle) flower extract, salicornia herbacea extract, allantoin, xanthan gum, butylene glycol, adenosine, dipotassium glycyrrhizate, aloe barbadensis leaf powder, fragrance.
While iHerb strives to ensure the accuracy of its product images and information, some manufacturing changes to packaging and/or ingredients may be pending update on our site. Although items may occasionally ship with alternate packaging, freshness is always guaranteed. We recommend that you read labels, warnings and directions of all products before use and not rely solely on the information provided by iHerb.


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Innovative technologies are optimizing Tarfaya wind's energy output and therefore helping make Morocco's plan for a sustainable future a reality.
On Morocco's southwest coast, a steady wind blows in each day from the Atlantic ocean. Today, the wind brings a new way of life not just to this coastal region, but to all of Morocco, as the wind becomes an important source of renewable energy.
Tarfaya is the site of Africa's largest onshore wind farm to date with a capacity of 300 MW – enough power for 1.5 million homes. By 2020, Morocco plans to cover 42% of its energy needs with renewable sources. A target raised to 52% by 2030.
For Tarfaya, the Siemens wind turbines have been specifically adapted to withstand the corrosive conditions of both the salty ocean winds, desert sandstorms and the year round hot weather. The turbines are equipped with a cooling system designed for high performance in challenging, very dry and dusty sites. This special protection results in less turbine downtime and higher annual energy production.
The wind farm is connected to Morocco's power grid via Siemens energy management solutions including transformers and control systems, ensuring a reliable supply of electricity for all the homes and businesses depending on it.
The renewable power generated from Tarfaya's wind turbines is expected to offset 900,000 tonnes of CO2 emissions each year.
So, thanks to Tarfaya's wind, Morocco is well on the way to reach its ambitious goals for economic development, environmental protection and quality of life.
Capturing the power of desert winds– and turning it into clean energy millions rely on. That's Ingenuity for life.
State-of-the art wind turbines
Tarfaya wind farm is equipped with a state-of-the art type of wind turbines – the geared SWT-2.3-101 – that is ideal for moderate wind conditions. Its 101 meter rotor is specifically designed to catch more of the wind and optimize energy output.
The SWT-2.3-101 turbine sets the industry standard. Its design means that this robust onshore geared turbine offers low energy-production costs and proven reliability.
All geared turbines combine a rugged structural design, automatic lubrication system, internal climate control, and a slip ring-free generator system – a combination you can rely on, since it contributes to the turbines' exceptional availability.


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To celebrate the release of their first new music in 2 years, Looking For Alaska will be shaking off those post-lockdown blues by hosting a single release gig at Nivara Lounge!'Fall Into You' is the first single from their upcoming album 'Light and Shadow,' which is due for release this November. Featuring strong Angus & Julia Stone vibes, the song was produced and mixed by the legendary Ben Edwards in Lyttelton, and features fiddle playing by the amazing Pascal Roggen from Albi and The Wolves. This is the first live show from Looking For Alaska this decade, following on from a busy 2019 which saw the duo tour Europe and deliver acclaimed performances at TSB Festival of Lights, Hamilton Gardens Arts festival and Whare Flat folk festival, where they shared the bill with Nadia Reid and Aldous Harding. Show starts at 8pm, with support from local indie-folk artist Reece Gielen. Don't miss out on whats sure to be a great night of music!
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Who am I?
Asking this question is my first memory of life. I was three years old, and it seemed inadequate to define myself in terms of the answers that I was given which were nothing but attributes attached to me at birth, such as name, family, religion, race, and nationality.
At seven, I wanted to renounce the world. The life cycle of human beings seemed no different from that of butterflies, with one stage of life following another in tedious sequence.
At fifteen, I took to living in libraries, and buried myself in a tomb of books from where I was reborn, after years. As I wrote my first novel, I rewrote my life, reconstructed my reality.
Electronics engineer, ecommerce consultant, literary writer, eclectic reader: out of the many dimensions of my identity, I choose that of the seeker to define me.
In 'The Power of Myth', Joseph Campbell mentions three Sanskrit terms – Sat, Chit and Ananda: Being, Consciousness and Bliss, each of which lead to the ocean of transcendence where all searches end. Like Campbell, I rejoice in following the path of my bliss, seeking the meaning of self and reality in the study and practice of literature.


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Kind of kisses that excite women
Kissing is a very stimulating action. For women, kissing is very exciting and very important to be conquered action. They are important for men also.
Kissing is an important tool for preliminary before sex, it helps intercourse.
Here are some tips to kiss women in a exciting way:
- Kissing various parts of the body: It is advisable not only to kiss woman's mouth. Passionate kiss visiting different parts of the body such as the neck or nape, will be a very pleasant stimulation for them. We can also caress and even apply small bites.
- Kissing her breast: Her nipples are a very erogenous part of women body. it is advisable either accompanying kissing cuddling.
- Kissing innovate: As women are more aroused, you can continue kissing all his body and let the situation come through.


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Developing a new and practical system to manage pig manure more efficiently, as a means to significantly reduce NH3 emissions and produce green energy.
Projects & Practice
Total results: 5.
Modernisation of a rice farm in Portugal through the application of precision farming in its irrigation infrastructure.
A major exporting agricultural company in Portugal, used EAFRD support to develop a state-of-the-art innovative, greenhouse production unit.
Installing an efficient irrigation system in a fig orchard helped to better manage water stress for the trees and increased the quality and volume of production.
A company used RDP support to install 9 ha of infrastructure for the production of fresh herbs, aiming to take advantage of the increasing demand for high-quality fresh produce in the European markets.


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This week we finish our interview with Cecily White-Cooper, who is a teacher and a mother of twins. She also has a podcast of her own on teaching: Teacher CES Podcast. In part 2 of our talk with Cecily, we discuss what is like being the mom of twins.
We discuss what it was like for her finding out she would be having twins, what are the biggest differences giving birth to twins over having a single baby, and what it's like to suddenly have two newborns to care for. We also discuss challenges that come with having multiples as well as any misconceptions people might have about raising multiples. We also touch base on how friends and family can help out a new mom of multiples and provide any support.
We had a great time talking with Cecily and we know you will enjoy this conversation we had with her. For more information on Cecily and to listen to her podcast, visit:
Podcast website: http://teacherces.libsyn.com
Instagram: www.instagram.com/teacherces
Twitter: https://www.twitter.com/teacherces
Facebook: www.facebook.com/teacherces
Podcast: Play in new window | Download
Subscribe: Android | Email | Google Podcasts | RSS |


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From his early experimentation with techno and acid house to his groundbreaking contributions to drum & bass music, GCG's art and craft has perpetually evolved regardless of his individual successes in each of those genres. He is perhaps best known for his early work in the Manchester acid house scene in the late 1980s and the track "Voodoo Ray". At that time, he specialized in techno music produced using equipment such as the Roland TB-303 bass synthesizer and the TR-808 drum machine (he sourced much of his equipment from Johnny Roadhouse, a second-hand music shop on Oxford Road in Manchester).
"I make music to dance to. If you can't dance to it, it's not dance music – just like if you can't eat, it's not food. (...) I don't mean mimicking soul freedom. Prove your groove." (aguycalledgerald.com). Gerald Simpson has recently released an album called "Proto Acid / The Berlin Sessions" to the Laboratory Instinct record label, runs two record labels and has s radio show to the Japanese Samurai. Neither his schedule is poor; gigs in London, Berlin, Manchester, Montreal, Frankfurt, to name just a few. He has also released several EPs and remixes to labels such Sender, Split, Laboratory Instinct, Rephlex Records, K7, Strange Fruit, even Sony.
A Guy Called Gerald: Because Simpson was my slave name.
Beat Factor: You make music for almost 20 years, right? How do you still manage to maintain your sound fresh and to keep it in the forefront of dance music?
A Guy Called Gerald: I keep it in the fridge.
Beat Factor: Let's speak a bit about your latest project from Laboratory Instinct. It's a double vinyl release and a mix CD called "Proto Acid / The Berlin Sessions". How would you describe the sound of this new album?
A Guy Called Gerald: A smorgasbord of house and techno music.
Beat Factor: The album release was in August. Any recent feedback and comments regarding it? How would you say people received the new material?
A Guy Called Gerald: I've had positive responses from everywhere apart from France. I think most people who have heard me in the last decade were probably surprised as the album not jungle or experimental breaks or something.
Beat Factor: What's the significance of this new album and what did you try to express through it?
A Guy Called Gerald: The significance is you should never judge an artist by the genre you try and put them in. I tried to express the multi-diversity and transmogrification of my writing skills as the first UK house producer.
Beat Factor: A Guy Called Gerald is the owner of two record labels, Sugoi Recordings and PROTECHSHON. What's new on these labels?
A Guy Called Gerald: The labels are basically rough outlines for producing jungle / breaks on one level and on the other level producing house / techno (and anything else unbreakable). The next release on Protechson is the second release in the live series I'm doing but will be recorded at a party in London.
Beat Factor: "Every five minutes there's a new music coming out, but when I check it - it's just the same thing. It's time to move on, I can't wait any longer". Has something changed in your music approach from the last year? If not, what do you think should be changed in the electronic dance music?
A Guy Called Gerald: Something changes in my music from show to show using the feedback of people at the parties I play at as an inspiration to progress in a positive way. I think artists need to stop relying on the machines for the groove – they should actually push the machines to make the groove that they want, the groove that they hear in their head (if they do hear anything). We need to separate the real inventors of groove from the machine operators.
Beat Factor: How much time do you need in order to produce a tune? Is it easier now than back in the ' 90s?
A Guy Called Gerald: I need at least half a minute to set the studio up, and another 15 minutes to create a groove that doesn't sound like a machine. I think after about half an hour you should have something that sounds like it's never been done before if you are not relying on the 4/4 beat to drag you along. Yes, it's 90% easier.
Beat Factor: What studio system do you use at the moment?
A Guy Called Gerald: I use new school retro software.
Beat Factor: You live in Berlin, but at the moment London should be considered a common place for you. Where can you express yourself the best as an artist?
A Guy Called Gerald: I'm actually from Manchester and I'm living in Berlin. London is for the Pete Tong's and Judge Jules type people.... They took house music to another level. I'm not worthy of that kind of mass production house-type thing. I'm more of an artist straight-to-the-people kinda guy. I can probably express myself best as an artist at a gig because at a show there is nothing in between me and the people (apart from maybe the sound guy).
Beat Factor: For those who didn't catch anything yet from you, what should they look forward to at the moment? But in the future?
A Guy Called Gerald: They should look forward to hearing the last decade and a half of the history of dance music that was denied to them by the mass media. I think they are very lucky to have a second chance. I mean, they could have ended up thinking dance music was all about some cheesy bedroom freak who had no funk or soul in his bones but had been signed up by his mate who had a quota to fill at some cheesy record label.
My aim is to give the machines some emotion in my productions and when I play out live. And when I say live, I mean LIVE, not playing mp3s with some dj software. I'll be giving the audience the experience of the difference between the mp3 and a 303.
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A Guy Called Gerald: I don't think there is an old school generation of dance music DJs as far as I'm concerned. Most of the old ones are fat balding white guys who can't dance in the first place. I think the young DJs seem to be following the balding old ones and not dancing either. They use the label of dance but it almost sounds like a ridiculous idea. Someone into dance music should know how to dance. If I didn't enjoy dancing I wouldn't have gone out and bought a drum machine in the first place so I could have continuous rhythms to dance to. . I think sometimes people forget DJs are there to be selectors and not rock stars. But at the end of the day, it doesn't really matter – the actual feeling of the funk is so far removed from the music that even when I go out and try and get my groove on it feels like I become a spectator sport for the dance floor – it's so alien to express yourself to dance music!
Beat Factor: What's your concept regarding "A Guy Called Gerald"'s music? Are the new tracks like a challenge, or do you want to stick to the "Gerald" style?
A Guy Called Gerald: All the time I aim to make something completely new.
Beat Factor: In what manner do you think an artist gains exposure in the front of media? And in what capacity do you think media can turn a simple producer into a future hero?
A Guy Called Gerald: Most artists gain exposure through the media if the PR person that they are paying to communicate with the media writes a press release that says "this artist is the best thing since sliced bread" and then sends it out to the media. I've found that most media now just cut and paste what the press release says.... In a way, computers have made the entire creative structure of everything from making movies to writing articles about an artist, one-dimensional. It depends on how much money the artist or label has to spend whether the simple producer is turned into a future hero. But these times are dying.... With the MTV generation coming of age, a younger generation is finally seeing through this financially trumped up showbiz freaks. Media is fragmented a lot more now too and people get there information in so many more ways.
Beat Factor: Where can people see you in the next months? Do you have a special future gig that you'd like to share it with us?
A Guy Called Gerald: Yes, I'm going to be doing gigs in places like London and other bigger cities but it would be nice to play in more alternative places outside the main media zones and play some of the smaller cities. I dream of doing an Eastern European tour that maybe would take me into Asia – just doing small towns and cities. Maybe I could even expose people to an alternative type of black music outside of rap. It seems like in this new century, everyone who's black and a musician is supposed to be a rapper and a hip hop dj. I would like to expose them to the funkier tronic side of black dance music.
Beat Factor: Robots kill humans VS Humans kill the robots?
A Guy Called Gerald: Humans make robots.
Beat Factor: What new technique relevant and useful innovations do you think that the last years brought us?
A Guy Called Gerald: Mass communication of the internet and the greater compression of information.
Beat Factor: Do you consider that the 21st century is built around the idea of "fast-food"?
A Guy Called Gerald: Yeah, I think so, I think that's the way it is being mapped out. But there are movements of people who live more of a "boutique" style life who are more interested in individuality, personal experience and independence.
Peace Gerald
foto: ©Kniestphotography.net
special thanks to Megan @ A Guy Called Gerald


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Google Doodle Celebrates the Coming of Spring
Today's Google Doodle celebrates the equinox and the coming of spring in Earth's northern hemisphere, both of which occur today, March 20.
The equinox is an event that occurs twice a year, when the sun crosses the celestial equator, and the day and night are approximately equal in length.
It is traditionally connected with the coming of Spring in many different cultures, usually marked by harvest festivals falling on or near the same date.
To mark the coming of spring, today's flowery Google Doodle has been designed by Finnish clothing design company Marimekko.
The company has had a big influence on the fashion industry, especially in the 1960ies and the 1970ies.
One of the most famous design elements Marimekko has introduced is the flower that replaces the big "G" in today's Doodle - that same flower was printed on a dress worn by Jacqueline Kennedy throughout the 60ies presidential campaign.


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Zombie School Ghoul
"Zombie School Ghoul" will begin after the advertisement.
Briefly explain your problem
Zombie School Ghoul
Believe it or not, zombies have schools too! Zombie Secondary School is one of the most famous ones. And tonight the students are throwing a party to say welcome to winter. Combine the scary and pretty pieces together and let your girl steal the hearts of the zombie teenagers!


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Jamie joined Granville West Group in 2014, prior to which she gained experience in the investment and financial services industry in various roles within a private real estate investment firm. This combined experience has provided her with exposure to and expertise in many aspects of the financial industry. Her detailed knowledge of client needs and aptitude for financial analysis enable her to deliver portfolio and insurance information in meaningful and easily-digestible formats, enriching the client experience through simplicity and clarity. In her current role, Jamie provides consultative guidance and support to her clients to address their current and future needs. Her passion is in educating and assisting individuals as they pursue their own financial and retirement goals.
Wealth Management Essentials (WME), 2017
Canadian Securities Course (CSC), 2015
Conduct and Practices Handbook Course (CPH), 2015
BA, Economics (Honours) – Simon Fraser University, 2013


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Create an exceptional scholar experience by making studying more customized, collaborative and cell, making certain outcomes are optimized and that graduates and unemployed obtain the career assist they want to succeed in the work place. Whereas universities in Europe and the USA regard the NSC issued by the IEB as proof of adequate education, the NSC issued by the South African authorities is just not regarded as a proof of enough education. Once you get copies of your e book, put them in the new car you got after you have been homeless and drive around the nearest large city on the lookout for folks holding indicators stating their need for a job. Each youngster with disability shall be identified on the secondary degree and his educational want assessed.
Miller used his place as Chair of the State Board of Education not just to promote privatization of the public school system, but also to guard his personal stake within the privatization marketing campaign, his family's Problem Constitution School. These reconsiderations will require a philosophy of education that has at its core a bountiful definition of intelligence and that honors multiple varieties of data and advances the humanistic, aesthetic, and ethical dimensions of an occupational in addition to extra conventional academic course of study. Please visit once more next week to find out about one other game performed on the conference. So let's start by facing a truth that we are all aware of on some degree, however usually strive no to face – our educational system is archaic.
In distinction, an income share" strategy to higher education finance dispenses (at the least in part) with the notion of a student-particular tuition amount. But those that obtained their diploma obtained a nicely-rounded education in classical knowledge and have been typically the elite in their community. It appears to me that there must be modifications within the South African education system to give more help to those that want it. It was beautiful to see the joyful faces of the scholars who passed their exams. Data-pushed cognitive applied sciences will allow personalized education and enhance outcomes for all.
Equalizing educational opportunities and human capital acquisition earlier is the one approach to make sure fairer outcomes. A common philosophy of recent education was to create individuals who were loyal to their country and supportive of the democratic process, which is what Addams promoted by means of her Hull Home. Let's do our half in serving to the federal government and not so lucky folks in reaching their desires by letting them know that EDUCATION IS A RIGHT. My son is always enjoying imaginatively and learns by means of enjoying with jigsaws, his construction toys like legos, video games and humanities and crafts.
I do imagine education shouldn't be acquire under indoctrination because it's limiting creativity and because the result, make people lazy. The second ingredient is that the bodily education activity needs to be something my children are desirous about. We are interest … Read More


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Moalem Weitemeyer Bendtsen uses cookies to compile statistics on the activity on the website. You can always remove cookies from mwblaw.dk again.
Moalem Weitemeyer Bendtsen offers legal advice in connection with all stages of a competition case, from preliminary investigations and administrative procedures to the handling of cases involving penalties or damages before the Danish courts as well as the European Court of Justice.Moalem Weitemeyer Bendtsen also advises on merger control in connection with transactions. We provide legal advice on the preparation and execution of the relevant transaction, comprising merger control examinations, due diligence, merger control filings and negotiations with the relevant authorities, including, in particular, Danish competition authorities. In addition, we have experience within state aid and related areas such as EU regulation of liberalisation and privatisation and not least EU law and public procurement regulation.
Pernille Nørkær


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Gibbous ♐ Sagittarius
Moon phase on 6 July 2025 Sunday is Waxing Gibbous, 10 days young Moon is in Scorpio.Share this page: twitter facebook linkedin
Waxing Gibbous is the lunar phase on . Seen from Earth, illuminated fraction of the Moon surface is 82% and growing larger. The 10 days young Moon is in ♏ Scorpio.
Monday Mon
Tuesday Tue
Wednesday Wed
Thursday Thu
Friday Fri
Saturday Sat
Sunday Sun
Previous main lunar phase is the First Quarter before 3 days on 2 July 2025 at 19:30.
Moon rises in the afternoon and sets after midnight to early morning. It is visible to the southeast in early evening and it is up for most of the night.
Moon is passing about ∠25° of ♏ Scorpio tropical zodiac sector.
Lunar disc appears visually 6.4% narrower than solar disc. Moon and Sun apparent angular diameters are ∠1771" and ∠1887".
Next Full Moon is the Buck Moon of July 2025 after 4 days on 10 July 2025 at 20:37.
There is low ocean tide on this date. Sun and Moon gravitational forces are not aligned, but meet at big angle, so their combined tidal force is weak.
The Moon is 10 days young. Earth's natural satellite is moving from the first to the middle part of current synodic month. This is lunation 315 of Meeus index or 1268 from Brown series.
Length of current 315 lunation is 29 days, 8 hours and 40 minutes. It is 2 hours and 15 minutes shorter than next lunation 316 length.
Length of current synodic month is 4 hours and 4 minutes shorter than the mean length of synodic month, but it is still 2 hours and 5 minutes longer, compared to 21st century shortest.
This New Moon true anomaly is ∠36.2°. At beginning of next synodic month true anomaly will be ∠60.5°. The length of upcoming synodic months will keep increasing since the true anomaly gets closer to the value of New Moon at point of apogee (∠180°).
1 day after point of apogee on 5 July 2025 at 02:29 in ♏ Scorpio. The lunar orbit is getting closer, while the Moon is moving inward the Earth. It will keep this direction for the next 14 days, until it get to the point of next perigee on 20 July 2025 at 13:52 in ♉ Taurus.
Moon is 404 801 km (251 532 mi) away from Earth on this date. Moon moves closer next 14 days until perigee, when Earth-Moon distance will reach 368 047 km (228 694 mi).
5 days after its descending node on 1 July 2025 at 03:46 in ♍ Virgo, the Moon is following the southern part of its orbit for the next 8 days, until it will cross the ecliptic from South to North in ascending node on 15 July 2025 at 10:42 in ♓ Pisces.
18 days after beginning of current draconic month in ♓ Pisces, the Moon is moving from the second to the final part of it.
11 days after previous North standstill on 25 June 2025 at 01:43 in ♊ Gemini, when Moon has reached northern declination of ∠28.402°. Next 2 days the lunar orbit moves southward to face South declination of ∠-28.423° in the next southern standstill on 9 July 2025 at 06:03 in ♐ Sagittarius.
After 4 days on 10 July 2025 at 20:37 in ♑ Capricorn, the Moon will be in Full Moon geocentric opposition with the Sun and this alignment forms next Sun-Earth-Moon syzygy.


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Demographic Factors Affecting Internet Using Purposes of High School Students
Volume 5 - Issue 1
ABDULLAH FARUK KILIÇ CEM OKTAY GÜZELLERPages: 34-45 Download Count : 2894 View Count: 2451
This study aimed at determining the impact of demographic factors on the Internet usage purposes of high school students. The population of the study consisted of students between 9th and 12th grades from the Anatolian high schools, science high schools, social sciences high schools, sports high schools and fine arts high schools in Turkey. The sample was chosen through the stratified and cluster sampling procedure. The students were chosen randomly depending on the regions of their school attendance. The sample for this research numbered 3170 students. The research was conducted in the second term of the 2014-2015 academic year. The data were obtained through online forms and the bases of participation are honesty, sincerity, and volunteerism. The data collection tool is a questionnaire and a demographic information form prepared by the researchers. Chi-square Automatic Interaction Detector (CHAID) analysis was conducted through SPSS in order to determine the demographic factors affecting the purposes of internet usage among high school students. The results of this research show that 9th grade students in Turkey mostly use the Internet to do homework while students from other grades mostly use the Internet for social networking. The male students use the Internet for playing video games more frequently in comparison with female students. Also, socioeconomic status affects the purpose of Internet usage. Hence it is suggested that teachers talking to male students might use the examples of computers and games and with female students they might relate the topics to social media.
- Internet Using Purposes
- CHAID Analysis
- High School Students


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A KPI (Key Performance Indicator) is a metric tied to a target. It demonstrates how effectively a business is doing at achieving its objectives. Good KPIs act as a compass guiding an organization on the right path to success.
KPI dashboard templates simplify complex data sets through data visualization to provide at a glance awareness of current performance to help make better business decisions.
Which ones should you consider?
Here are the 10 best KPI dashboard templates to keep your business strategy on track.
Databox allows you to create your own database or import an existing database from any source.You can add Images to your data, select your style, fonts, colors and then publish your database for the web – including On-Line Searching of your published data. Databox is a mobile-first business analytics platform built to help you understand what's going on with your business. Supported by many visualization types (line, bar, pie charts, funnels, tables, …), you can present your data on your office TV, and collaborate and discuss your metrics with others
Domo Combines a powerful backend that sits on top of and connects into any existing system where data lives, including those for customer relationship management, enterprise resource planning, human resources and financials, as well as any data repository or current reporting system. is a great self-service business intelligence (BI) tool that offers a wide data set, connector support and delivers a unique set of social collaboration tools as well. Domo seems to be best suited for situations in which a team is sharing a dashboard on key metrics.
Dundas BI is a next-generation business intelligence platform that was released in 2014. It combines both business intelligence and analytics tools into one platform that can be accessed as a standalone or easily embedded into other applications. The flexible and scalable solution has a strong focus on self-service, meaning any user can analyze data and create dashboards regardless of job role or technical BI skill. It has drag and drop abilities and can also be fully customized.
iDashboards address the needs of organizations worldwide seeking an intuitive, collaborative way to view and analyze their critical business information. Because it's so simple to learn and navigate, iDashboards cuts back on the extensive training time typically associated with complex Business Intelligence solutions. iDashboards is a great fit for financial services, government, healthcare, manufacturing, and retail, but can be applied to many other industry verticals.
Klipfolio is a fully cloud dashboard application that enables real-time visibility into the data and KPIs behind your business, so that you can improve performance, relentlessly. Connect to hundreds of data sources online and offline, including: (a) web applications like Twitter, Moz and Google Analytics. Dashboards built in Klipfolio can be easily shared and viewed on browsers, wall-mounted TVs and mobile devices (iOS and Android). Klipfolio dashboard software is used by a wide variety of businesses, big and small, and by professionals working in a variety of roles, from marketing and sales to BI, consulting and executive management.
Qlik's unique selling points are that it ranks highest in customer loyalty, provides satisfactory performance, offers a wide variety of features, and is known for its product quality and overall market position. Qlik is probably of the few visualization tools that offers an integrated BI platform and comes bundled with adequate demos, training manuals, and tutorials that can easily fascinate clients and new customers, giving them insight in a fraction of the time they expect.
Sisense is an end-to-end business intelligence (BI) solution that was developed to be accessible for any type of user, even those with little or no prior experience with BI software. Their full suite of applications provide users with the tools they need to manage and support business data with analytics, visuals and reporting. This out-of-the-box system doesn't require lengthy implementation or training, so businesses can have it up and running quickly. Sisense was chosen as one of the Top 10 BI Vendors of 2013 by CIO Magazine and "Best in Show" at the O'Reilly Big Data Strata conference.
Tableau is tailored to meet the needs of anyone looking to explore and analyze key business data, regardless of technical or analytical background. Tableau has taken years of research and built best practices right into the solution. Tableau has become an industry standard with the a bility to connect many data sources and create impressive looking visualizations easily. The interface feels much more modern than some of its competitors.
ThoughtSpot has a user interface driven by a search bar, much as a user of Google experiences, and natural language queries can be entered using the language of the business concerned. Combining a search oriented approach with BI is really quite innovative, especially as the dominant paradigm right now is a drag and drop graphical interface. ThoughtSpot is growing quite quickly, and saw 800% growth last financial year – so the approach is clearly attractive to business users. ThoughtSpot has also made it into Gartner's Magic Quadrant.
Zoho CRM has a version for both enterprises and small businesses. Each has its own pricing model, with several options available for SMBs. The software is geared toward any business that has a need for customer relationship management. Primarily sales organizations will benefit from Zoho CRM's features. One other distinguishing feature is Zoho has never acquired any venture capital, angel investors, or loans. They are entirely a bootstrap operation,
Do these KPI dashboard template give you a good idea of what's available? Would you add any others? Does your organization need guidance with KPIs and KPI dashboards?


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The new one has a more religion-focused angle.
Stelter bringing Indigenous workshop back to Tri-Region, with twist
Parry Stelter believes the workshops he hosts on Indigenous reconciliation can heal centuries-old wounds.
The Alexander First Nation member and Indigenous activist has been running his meetings for a number of years and brought out his standard presentation to the Hope Christian Reformed Church just north of Stony Plain in November. He will be back Feb. 8, and, whereas his first talk was on general issues for his people and Indigenous Canadians across the country, the new one has a more religion-focused angle.
"Everybody was very excited after the last one," he said. "They felt that they had learned a lot and that this work needs to continue on. This one helps to bridge the gap between Indigenous people and church. Because of all the baggage that happened over the years, there are still a lot of people that believe in god and the church, but they still have a lot of emotional baggage and are a little hesitant about coming out."
Statistics Canada data from 2011, the most recent year the federal government appeared to have on file, showed that 65,000 people in the nation followed traditional native religious beliefs. Stelter added that the amount of people who still believe in Jesus from his cultural background surprises him, and, during the event, said he wants people to feel comfortable and be able to move on from bad memories.
"It is not a proselytizing thing," Stelter said. "The approaches that colonialism did, it is not that. We are addressing those who are interested, but struggling with certain issues. If non Indigenous people attend, they will understand and reach out more without repeating mistakes."
The Reconciling Indigenous People to the Church and to Christ workshop begins at 9 a.m. Stew and bannock will be served for lunch and it costs $20 to attend. Those interested in going must RSVP to 780-240-9802 through texting or calling by Friday, Feb. 7 to confirm presence.


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How to Apply Stucco Siding to Shingle Style Wood Panels
Stucco siding is a fine-grained mixture of Portland cement, sand, lime and water. It's possible to apply stucco over shingle-style wood panels or any other substrate. Because stucco is porous by nature, it's important to provide a way for water that infiltrates the stucco surface to channel away from the underlying wood shingles or rot may develop.
Install building paper over the wood shingles, starting at the lowest point on the wall. Work horizontally from the bottom of the wall up. Attach the paper with staples. Overlap seams by at least 3 inches to prevent water from seeping in from behind.
Mark the lowest point on each corner of the wall where you plan to apply stucco. Snap a chalk line between the two points. Check the line with a carpenter's level. Adjust the chalk line as necessary.
Attach a base strip along the chalk line using galvanized roofing nails.
Fasten metal lath sheets to the wall over the building paper. Hold the sheets in place with roofing nails spaced 16 inches apart. Nail the sheets into wall studs if possible. The bottom of the lowest lath sheet should rest along the base strip.
Mix the stucco according to the manufacturer's directions. Force a layer of stucco through the mesh of the lath sheets and onto the building paper. The layer of stucco should be approximately 3/8-inch thick.
Drive a row of nails through a short length of scrap 1-by-2-inch lumber, spacing the nails approximately 1 inch apart.
Make horizontal marks across the slightly damp coat of stucco with the nail strip. This roughened surface helps the next coat of stucco adhere better.
Dampen the first coat of stucco if it dries completely before receiving the second coat. Spread the second coat about 3/8-inch thick. Allow this coat to cure for at least 48 hours before proceeding.
Apply the third coat of stucco. This layer should be 1/8- to 1/4-inch thick. Create a smooth texture by running a wood float over the surface before it dries. Make a dragged surface by scraping a piece of 2-by-4-inch lumber across the surface. Use a trowel to create arcs and swirled textures in the stucco.
Things Needed
- Building paper
- Stapling supplies
- Chalk line
- Carpenter's level
- Galvanized roofing nails
- Nailing tools
- Metal lath sheets
- Trowel
- Stucco
- Scrap 1-by-2-inch lumber
- Nails
- Wood float
- Scrap 2-by-4-inch lumber
- Measuring tape
- Add coloring agents to the second and third stucco coats, if desired.
- Using premixed stucco is easier than mixing your own.
Photo Credits
- Jupiterimages/Photos.com/Getty Images


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DOVER — The Children's Museum of New Hampshire is kicking off the celebration of its 30th year with a party for kids and families on Sunday, Sept. 29. From noon-5 p.m., there will be fun activities for all, as well as live entertainment and traditional birthday party refreshments, generously sponsored by corporate supporter Bank of New Hampshire.
Guests at the Children's Museum's 30th birthday celebration can decorate their own sparkly birthday crowns to wear and take home, get their faces painted and play party games. Birthday cake and ice cream will be served all afternoon.
At 12:30 p.m. and 2 p.m., there will be live musical performances by Danny Lion, the new children's music project from award-winning composer, Dan Flannery. Kids and parents will enjoy Danny Lion's fun, danceable rhythms and engaging storytelling through song. Young audience members will be invited to play hide and seek with a snail, dance like a crab, go on a bus ride, and move to the music! More information on Danny Lion can be found at www.dannylionmusic.com.
All birthday celebration festivities are included in the regular price of admission: $9 for children and adults, $8 for seniors, and free for museum members and children under age one. Directions and other information may be found at www.childrens-museum.org
The Children's Museum was founded in 1983 in Portsmouth and moved to its current larger location in Dover in July 2008. During the past 30 years, the Museum has grown from a small-capacity local museum to a flourishing regional institution that welcomes 90,000 annual visitors from all 50 states and beyond. Throughout its history, the Children's Museum has been recognized for excellence in programming and leadership, most recently winning the NEMA Leaders in Innovation Award and the NEFA Creative Economy prize. This 30th year will be marked by a variety of special programs and events.
The not-for-profit Children's Museum of New Hampshire is located at 6 Washington St. For more information, please call the museum at (603) 742-2002 or visit www.childrens-museum.org.


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Having a beautiful smile can help boost your confidence and improve your quality of life. We offer many services to help you achieve your goals including teeth whitening, teeth straightening, and porcelain veneers.
If you want a bright, white smile there are a variety of options to fit every budget. You can restore your stained or discolored teeth in one visit or opt for a take-home whitening kit.
Get a whiter smile in less than an hour with the Zoom!® Professional Whitening System. When you come to the office, a whitening gel will be placed on your teeth and activated by Zoom!®'s special light technology. The light activates the hydrogen peroxide to bleach your teeth to a dazzling white – up to 8 shades whiter.
Sapphire is one of the fastest in-office whitening systems. In about 45 minutes you'll have a whiter smile using Sapphire's unique bleaching gel.
Take-home Whitening Kits
Take-home whitening kits are rising in popularity as more and more people want whiter smiles in the convenience of their homes. These take-home kits are stronger than the whitening kits available at the drug stores and customized for your needs specifically.
Invisalign® - You can straighten your teeth without unsightly brackets and wires when you use Invisalign®. By using a clear, removable aligner which changes about every two weeks, your teeth will straighten little by little in just six to eighteen months. Comfort is a top priority, as you can remove the aligners to eat all of your favorite foods.
Lumineers® are custom designed porcelain shields bonded to the front of your teeth to transform your smile. Fix staining, uneven spacing, awkwardly shaped teeth, and lengthen short teeth with the contact lense-thin Cerinate® porcelain that has been proven to last for over 20 years. Usually there is no drilling required and you can have a beautiful new smile in just a few visits.
If you have a cracked tooth or possible tooth decay, there are several treatment options available to restore the functionality and esthetic of your teeth. Your smile can be restored with dental implants, crowns, onlays or inlays.
If you're missing teeth, you may consider dental implants as an alternative to dentures because they are very natural looking and feeling. One or more artificial teeth can be planted in your jaw without affecting the bordering teeth.
Dental crowns are a tooth-shaped cap that covers the tooth, right above the gum line to restore a tooth's shape, size, strength, or appearance. Crowns are appropriate when there is decay to the tooth's cusps and it's too late for a traditional filling, onlays, or inlays.
Onlays and inlays are used to protect against tooth decay while conserving as much of the natural tooth structure as possible. They are bigger than a traditional filling, but smaller than a crown. When there is little damage to the cusps of your tooth, an inlay is used like a puzzle piece to fit into the remaining portion of the tooth. When there is more extensive damage, onlays are placed over the cusps on the tooth adding strength and durability.
A crown is necessary if a tooth has severe decay, however sometimes dentists recommend a crown treatment when onlays and inlays are a viable option. Onlays and inlays are preferable to a crown because this treatment preserves as much of the healthy tooth structure as possible. A crown will remove part of the healthy tooth structure which can cause trauma to the nerve and lead to a root canal years later.


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Bill Holroyd
Advisory Council
In 1982, Bill set up his own foodservice distribution company, Holroyd Meek. Booker acquired the company in 1995 and Bill started his own investment company and has invested in over 25 start-up and second-stage companies.
Bill is the founder and current chairman of OnSide Youth Zones which provide young people aged 8–19 years old (25 for those with a disability) somewhere safe to go, something to do and someone to talk to in their leisure time.
London +44 20 3039 3040


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An outdoor barbecue of souvlakia and baby lambs was held on Sunday, May 7 at the Geros Tou Morea chapter of the Pan Arcadian Federation of America celebration on Sunday, May 7. The event took place at an NYPD closed street in front of the clubhouse at 27-02 39th Ave., Astoria. With cars looking to cut into 27th St. and 39th Ave, the NYPD police presence was needed.
Lambs were barbecued for authentic Greek cuisine by Apostolos Lagos, Chairman, and his staff. He supervises the barbecues of the summer picnics. "I enjoy helping," he said. "I have been at the clubhouse all week preparing for this social. Mr. Demetrios Tsiavos of Broadway Meat Market on 21 St. and 21 Ave. donated his services in marinating the lambs and souvlakia. Tina Vournas is in charge of the youth group.
Demetri Valkanas grew up down the street from the cultural center. "My father wanted us to be close to people from his village," he said. "My father, George, who passed away suddenly a four years ago, taught me to love Greece and be fluent in the language. My grandfather, Demetri, and his three brothers fought in WWII on the Albanian front. Only my grandfather survived. My grandfather's three brothers, Andreas, Panagiotis and George, were German prisoners of war. They were executed in Tripoli, for missing a curfew. My father was a member of Geros Tou Morea when he immigrated in around 1957." He is chairman of the Education Committee and Dance Group.
The 2017 Executive Board includes: Chris N. Vournas, president; Apostolos Lagos, 1st vice president; Demetrios A. Filios, 2nd vice president; Evangelia Sarfoglou, general secretary and Demetris Boregioukos, treasurer. Founders were Tom Angelopoulos, Mike Bakopoulos and Alexander Sioris.


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Air Purifier Selection Tool
Find your ideal air purifier based on the specific needs of your home or office.
Use our interactive selection tool to match you with the perfect air purifier. We will ask a few simple questions and you will immediately receive a suggestion regarding your ideal air purification solution.