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Category: Truth
Taco Bell is as American as apple pie.
Wherever there's a pile of sawdust-filled meat stuffed into a tortilla, or a bathroom toilet overflowing from a massive dump, you can be sure that not far away is a Taco Bell.
And you can be sure that inside that Taco Bell, America's founding principles of capitalism and obesity are being practiced.
But in Downey, California, freedom has withered. The smell of spicy meat no longer emanates from loosely cleaned microwaves. Mountain Dew Baja Blast no longer flows from the taps. Cheese is no longer rolled up in a tortilla and sold as a menu item.
The world's first Taco Bell–Taco Bell número uno–is closed.
It went out of business long ago. This 400 square-foot slice of paradise stopped selling delicious taco-like food products during the Reagan Administration, when business dwindled due to the rise of bigger, more popular restaurants with modern innovations like "indoor seating" and "drive throughs." A new era was dawning, and Taco Bell Número Uno was left in the past.
During a decade when wolves roamed Wall Street and girls just wanted to have fun, this little slice of "clielo" (Spanish for "heaven") couldn't keep up with the rabid consumption economy of a country that just wanted more and more. America didn't have time to wait 2 minutes for its tacos; it needed them in one. The joys of a simpler time were cast aside in order to embrace the coming fast-food revolution. Taco Bell Número Uno was forgotten, left to wither in the cold California sun, left to fade like the brightest stars of Tinseltown all inevitably did once their glory days passed. By the time George Herbert Walker Bush took office, not even the rats wanted its artificial cheesefood.
They say there's no place lonlier than being alone. That was true of Taco Bell Número Uno.
There were the memories. So many great memories, spanning so many good years. There was opening day 1962, when Taco Bell's founder, Glenn Bell, handed over the very first Taco Bell taco to an unsuspecting customer who had no idea what he was in for when he crunched into that 19-cent slice of faux-Mexican deliciousness. There was the first mariachi performance, which was held on the stage out back across from the fire pits, and all the white people pretending they liked it. And there was the time that guy fell in the fire pit and died, and they buried his body out in the desert without calling the cops. So many good memories.
If you lived in Downey, Californa between 1962 and 1986, Taco Bell was like your Times Square. It was the crossroads of the universe, where culture, art, and food intersected in a symphony of taste, sound, and light, very cheap lights from the Home Depot, to be exact.
This little taco stand, no bigger than a two-car garage, with its mission-style arches and its lack of indoor seating, changed the world. It took a fast food industry wedded to the idea of burgers and fries and turned it on its head by showing what happened if you just think outside the bun for once.
Now there are Taco Bells in every corner of the Earth. Sure they might not have mariachi bands and fire pits, but they have chairs, and they have the one thing that has never faded since Taco Bell Número Uno opened on that fateful day in 1962: people that like tacos.
It was safe in this knowledge that Taco Bell Número Uno could accept its ultimate fate. By December 2014, the Bell had tolled for Taco Bell Número Uno. The wheels of capitalism stop for no man, woman or restaurant. A vacant lot must be cleared and the seeds of new business must be planted, so profits can spring anew. Taco Bell número uno was set to be demolished this year.
Or so it thought.
You see, Taco Bell never forgot about Taco Bell.
And on November 19, Taco Bell cleared the lot upon which the world's first Taco Bell sat, not by smashing Taco Bell Número Uno to bits with a crude wrecking ball but by giving it new life.
The restaurant was loaded onto the back of a flat-bed truck, mission-style arches and all, for a glorious 45-mile parade through scenic Downey, California to its temporary resting place at Taco Bell Headquarters on Glenn Bell way in Irvine.
The entire event was livestreamed online to potentially dozens.
A Taco Bell being driven around on the back of a flat bed truck was livestreamed.
Perhaps it's a fate befitting the restaurant founded by Glen Bell that the move isn't a last ride, but rather a new beginning. After all, Bell launched numerous, short-lived franchise failures–Bell's Burgers, Taco Tia and El Taco–before birthing his Taco masterpiece.
Perhaps Taco Bell Número Uno, like Glenn Bell, can rise from the ashes to accomplish something even greater, and remind us that, like the cheese scraps we all secretly scoop up and eat at the end of our Taco Bell meal, there's still greatness left in all of us.
Taco Bell says the building's future and its final location are yet to be decided. Here's hoping they'll think outside the bun, just like the great Glenn Bell, founder of Taco Bell Número Uno.
The attacks in Paris, horrific as they were, brought out the best in humanity. In our darkest hour, the bright lights of libertè shone brightly. Mankind stood up to the barbarity of those who would see the accomplishments of civilization rolled back. It declared in one voice, "We will not be afraid."
Freedom rings, whether in the form of a HEROIC PATRIOT who blindly slams closed the door to safety in the face of refugees fleeing violence and persecution, or in the form of ANOTHER HEROIC PATRIOT who isn't afraid to call freedom's enemy by its real name: BARACK OBAMA.
Republicans did what they always do in times of crisis…LEAD.
I found this comprehensive list of the most heroic statements made by TRUE PATRIOTS since the Paris attacks. Here are the highlights:
1. Ted Cruz: Keep Out Them Muzlims!!!
The junior senator from Texas just introduced a bill in the Senate to ban any Muslim refugees from Syria.
Only Christian refugees, says Cruz. It's a totally understandable position, because like the Constitution clearly says, "Congress shall make no law respecting an establishment of religion, or prohibiting the free exercise thereof… but if you're not from around these here parts, we'll totally make laws that say what religion you can be." Principles. Founding principles. Let's get back to 'em.
And Cruz clearly understands what Obama can't, which is, it is that easy to spot a Muslim. Just look at 'em. They stick out like a sore thumb in a crowd of Syrian refugees.
Brown skin, don't let 'em in, right? Boom. WHY CAN'T WE ELECT THIS MAN PRESIDENT???
Cruz knows the only thing that matters is helping people who are like you. And why not? It's not like he worships a guy who told a parable about a guy helping another guy who was of a different ethnoreligious group, in order to illustrate the meaning of the word "neighbor."
On Fox News Radio on Sunday, he said this about his plans for Syrian refugees: "Heck, we may take them to the University of Missouri. … A lot of the students are so stressed out from feeling unsafe because somebody said a word they didn't like that they are not using their dorm rooms anymore. Maybe we can put them there."
Yeah, those bastards at Mizzou left their perfectly good poop-swastika covered dorms just because people were threatening to shoot them up. Well, let's see how they like it when we put a bunch of Syrians there. You guys kinda miss that poop-swastika now, don't cha? Well, that's what you get for not appreciating the opportunity to enjoy 2 American values, guns and racism, firsthand.
Yep, put the refugees in the Mizzou dorms. It solves 2 problems: keeping terrorists out of our country and getting those lazy blacks off the couch and into the workforce.
Oh, wait, no it doesn't. Oh well.
Mike Huckabee isn't obligated to help the suffering and the poor. It's not like he fanatically claims that all of his decisions are guided by a guy who said we should give away our possessions and help the less fortunate without any thought of ourselves.
He's under no obligation to love his neighbor.
"So you don't like that great idea?said Huckabee. "Fine. How about this one?"
"[L]isten, all of these feel good liberals who say we ought to be taking in refugees, how come they never end up in the neighborhood where the limousine liberal lives? Behind gated communities and with armed security around. Mrs. Clinton, you have suggested we take in 65,00 refugees, how many can we bring to your neighborhood in Chappaqua? Can you please just give us a number. That would be the question that I would like to ask her."
("Please" give us a number, Mrs. Clinton. Huckabee is definitely the most polite bigot.)
Yeah, why don't we just put the refugees in the homes of the "limousine liberals." Or better yet, the "private plane progressives"? Maybe even the "Diamond ring democrats". All those liberals are so rich, not like Republicans. Let them solve the world's problems and us Republicans will continue to do our job: causing problems.
Speaking of which…
"In Syria, take a big swatch of land, which, believe me, you get for the right price, OK? … What I'd like is build a safe zone … build a big, beautiful safe zone, and you have whatever it is so people can live, and they'll be happier."
(Not the worst idea. Close to it.)
Trump has stumbled upon a great solution here. Put the refugees in refugee camp–I mean "safe zones". Yeah, safe zones. What's not to like, they're safe because they're in a safe zone.
It's so easy.
I bet when the millions of displaced persons in Syria and the refugees living in camps nearby hear about the safe zone they're going to be thilled. Finally they'll be safe. Safe from the violence and mistreatment of the typical refugee camp. Safe from the barrel bombs targeting civilians which are frequently dropped by the Assad regime. Safe from ISIS.
So, who's going to keep them safe? Like all of the questions about Trump's policies, the answer is surprisingly simple: Don't worry about it.
Trump will simply tell you what you need to know: It'll be the biggest, most luxurious safe zone you've ever… You'll be very happy there, believe me.
Believe him. He's God.
Here's what you need to know about tonight's Republican debate:
1. Rick Perry is still in this race….
Oh, wait that was Ted Cruz. This is Rick Perry…
See how different they are?
Some people like to say all Republican presidential candidates are the same–that they have the same ideas–but I disagree. They are like 15 snowflakes, each one unique and perfect.
For example, yes, they all hate immigrants, but they each do it in a unique and individual way. Donald Trump says, "WE NEED TO GET RID OF ALL THE MEXICANS!!!" Ben Carson says, "We need to get rid of all the Mexicans."
Trump says "OBAMA IS NEVILLE CHAMBERLAIN!!!" Ted Cruz says, "Obama is Hitler." Ben Carson says, "Obama is Muslim."
Trump says, "GET RID OF THE GOVERNMENT." Rand Paul says, "Get rid of the government" with pubes on his head. Carson says, "Throw rocks and hammers and bricks at the government… to get rid of it." Ted Cruz says, "Get rid of something, but I can't remember what it is."
Totally. Different. Ideas.
2. Eisenhower is making a comeback!!!
As liberal rag MotherJones.com explains…
Donald Trump was asked about immigration at tonight's debate and answered with some ramble about Eisenhower or something.
Anyway, here's what happened on Google:
Congratulations, Eisenhower on officially getting more interest from 2016 Republican primary voters than Jim Gilmore, George Pataki, and Bobby Jindal combined, during your one minute of interest.
Also, congratulations America, for apparently not knowing who Dwight Eisenhower was.
It's no secret that lazy, good for nothing Communists want "wages" and "salaries." Well, at tonight's Republican debate, Billionaire Donald Trump, the man who is funding his own multi-million dollar campaign for president, told it like it is.
Here's what Donald Trump said.
And, not to be out gaffed, Ben Carson IMMEDIATELY followed with this…
So, in other words, eat your experience poor people!
Also, WTF was that map?
Take as long as you like. It doesn't get any clearer.
And, because I know you dirty liberal communists are about to ask, YES THE WAGES ARE TOO HIGH, and NO, THE RENT IS NOT TOO DAMN HIGH!!!
4. To sum up…
In other words, Hate Debate Milwaukee! November 2015 edition! is best summed up thusly…
Who in God's name does the Pope think he is?!?!
Jesus Christ!!!
First he tries to tell us the climate is changing.
And just because he's "infallible" we're supposed to believe him.
Nice try Pope, but would an infallible man drive a FIAT??? I think not.
Now, he wants to come down here to Washington, D.C., OUR NATION'S CAPITAL, TO JESUS'S HOUSE, and tell us that we can't sentence other people to death?!?!
What fun is that?
Here's what @pontifex said during his speech to Congress Thursday…
This conviction has led me, from the beginning of my ministry, to advocate at different levels for the global abolition of the death penalty. I am convinced that this way is the best, since every life is sacred, every human person is endowed with an inalienable dignity, and society can only benefit from the rehabilitation of those convicted of crimes. Recently my brother bishops here in the United States renewed their call for the abolition of the death penalty. Not only do I support them, but I also offer encouragement to all those who are convinced that a just and necessary punishment must never exclude the dimension of hope and the goal of rehabilitation.
What good is the Bible if we can't use its teachings to subject society's worst offenders (and a few hundred innocent people) to a long, excruciating murder by chemical injection?
"Eye for an eye," that's what the REAL, OLD-SCHOOL GOD taught. None of this PC, liberal "Do unto others" BS that the Pope and his buddy "Jesus" are laying down. Go back to your Bernie Sanders rally, hippies.
Coincidentally, the Pope also laid that "Do unto others" propaganda down during his speech to congress…
We need to avoid a common temptation nowadays: to discard whatever proves troublesome. Let us remember the Golden Rule: "Do unto others as you would have them do unto you."
What?!?! "Discard whatever proves troublesome" is LITERALLY the motto that Fox News reporters live by when they report their stories. I'm beginning to think this Pope doesn't understand anything about being a Christian (Conservative). He needs to stop taking selfies and watch some Hannity.
Speaking of watching Hannity, I'm hoping that's where Supreme Court Justices (and people who have the power to abolish the death penalty) Clarence Thomas, Samuel Alito, and Antonin Scalia were, because they WISELY decided not to attend Pope-bama's speech. That's right, the three CATHOLIC Supreme Court justices who support the death penalty couldn't find time in their busy schedules to see the Pope. I applaud this. Why would these all-powerful, lifetime appointees take time for a lowly elected official like the Pope. It would really be beneath them as, I'm assuming, would be listening to God's representative on Earth.
But while these three old men did well in cowering from the dangerous message of peace and acceptance delivered by an elderly, foreign man in a white robe, the real hero of the day was Republican Congressman Paul Gosar. Yes, this proud member of the United States Congress boldly condemned the Pope for making EVERY. FUCKING. THING. into a divisive, poltical talking point.
That's right, Paul Gosar went there. He cast the first stone.
As he wrote in a blistering, anti-Pope, liberty-sausage of an editorial for TownHall…
Media reports indicate His Holiness…intends to focus the brunt of his speech on climate change– a climate that has been changing since first created in Genesis. More troubling is the fact that this climate change talk has adopted all of the socialist talking points, wrapped false science and ideology into "climate justice" and is being presented to guilt people into leftist policies… If the Pope plans to spend the majority of his time advocating for flawed climate change policies, then I will not attend.
And he did not attend. As Daily Kos put it, the Catholic Congressman was, "not willing to walk about 500 feet from his office in Cannon to the Capitol." Suck on that, Pope, you self-righteous dick! Who do you think you are to spew your Communist ideas in PAUL GOSAR'S WORKPLACE?!?! WHO ARE YOU to make PAUL GOSAR walk 500 feet?!?! THIS IS AMERICA! NOBODY walks 500 feet, here!
…Unless we're walking to the ranch of a crazy racist who wants to start a shooting war with the U.S. Government. Paul Gosar did that…
…last year the congressman had the interest and the time to travel thousands of miles to criminal rancher Cliven Bundy's compound in Nevada. Gosar joined a knuckle-dragging gaggle of Arizona legislators like Chemtrail Queen Sen. Kelli Ward, who caravanned to the armed camp during the standoff with BLM. The Arizonans took photographs with the bigot Bundy and spoke with local media about freedumb and shit, then returned home and plastered the pictures on their websites—that is until the old coot told the world what he knows "about the Negro." Then the web photos disappeared…
So just to recap the day's Conservative talking points, team… Obama, Liberals, Pope, Walking=Bad.
Racist rancher, Paul Gosar, Death Penalty, Not Doing Unto Others=Good.
Got it? Okay, great. Now let's get to work.
Of course, there are some who seem to have fallen under the spell of the Pontiff's DANGEROUS MESSAGE OF LOVE FOR OUR FELLOW HUMAN BEINGS.
I am calling on Fox News to FIRE THESE PEOPLE IMMEDIATELY…
Starting with Sheppard Smith, who said this…
"I think we are in a weird place in the world when the following things are considered political. Five things, I'm going to tick them off. These are the five things that were on his and our president's agenda. Caring for the marginalized and the poor — that's now political. Advancing economic opportunity for all. Political? Serving as good stewards of the environment. Protecting religious minorities and promoting religious freedom globally. Welcoming [and] integrating immigrants and refugees globally. And that's political?"
"I think these were the teachings in the Bible of Jesus. They're the words of the pope, they're the feelings of the president. And people who find themselves on the other side of that message should consult a mirror, it seems like."
Shep, I really think you need to read your Bible, specifically Matthew 17:31 "Blessed are those who say 'Fuck the poor'," and the Letter From St. Paul to the EPA extolling the virtues of "clean coal".
Or maybe we're reading different Bibles…
At a town hall event in Rochester, New Hampshire Thursday night, Donald Trump got a question from a guy who was, well, exactly the kind of guy you'd expect to find at a Donald Trump town hall event…
…a PATRIOT!
The man made a perfectly reasonable point about Muslims, or as I like to call them, Obamas, because Obama is a Muslim, as this man clearly knew, because he came armed with FACTS!!!
Here's the exchange (CAPITALIZATION added for emphasis on the PATRIOTIC PARTS)…
MAN: "We have a PROBLEM in this country… It's called MUSLIMS. We know our current president IS ONE."
Now, at this point, I can see no controversy whatsoever. Let's continue…
MAN: "You know he's NOT even AMERICAN."
Oh, he knows. He knows…
TRUMP: "We NEED this QUESTION, this is the FIRST QUESTION."
MAN: "We have TRAINING CAMPS growing where THEY WANT TO KILL US… That's my question…
What? It's not.
There's a question…
TRUMP: "We're going to be LOOKING AT A LOT OF DIFFERENT THINGS. A LOT of people are saying that, and A LOT of people are saying that BAD THINGS are happening out there. We're going to be looking at THAT AND PLENTY OF OTHER THINGS."
Is this the same unspecified "lot of people" who say that the Constitution doesn't guarantee birthright citizenship? 'Cause I like those people.
I'd like to meet them.
Anyway, I see nothing remotely controversial in Trump's comments. He simply agreed with THE FACT that President Obama, wasn't born in America, which is familiar to Fox News viewers, because Trump said it on Fox, dozens of times–and which also happens to sound completely insane to everyone else…because they are wrong–and he also agreed that Muslims are building camps in the United States from which to attack us and that he's going to "look into it." This is also a confirmed news story from a reputable, non-MSM/non-libtarded source.
Just because there isn't any evidence doesn't mean it's not true libs…
Which should be the Trump campaign's standard response to all media inquiries about his comments by now.
But of course, all the libs FREAKED OUT…because they don't understand that civil rights don't apply to Obamas…
But maybe there is a silver lining to all of this anti-Christian outrage…
Mike Huckabee is not an egotistical man.
Mike Huckabee does not exploit people's willingness to buy into an extremely bigoted brand of anti-homosexual rhetoric.
Mike Huckabee isn't in it for himself.
Mine Huckabee just wants to do what Jesus calls all Christians to do: keep the gays from being married. And he's calling you to speak out and do the same, shouting it from the rooftops!!!
…unless you're Ted Cruz, in which case, sorry, there's no more room at the bigotry lunch table…
When Mr. Cruz, who met with Ms. Davis, exited the Carter County Detention Center, a throng of journalists beckoned him toward their microphones, but an aide to Mr. Huckabee blocked the path of the senator, who appeared incredulous.
Soon after, Ms. Davis emerged, apparently wearing the same clothes she had worn in court Thursday. Mr. Huckabee stuck close by her side, along with Mr. Staver and her husband, Joe, as they approached the reporters and cameras. Ms. Davis remained silent, letting Mr. Staver and Mr. Huckabee do the talking.
Mr. Huckabee, a former Baptist pastor, cast the dispute as a matter of religious freedom threatened by overreaching courts, while Mr. Cruz stood to the side, keeping an unusually low profile.
"If you have to put someone in jail, let me go," Mr. Huckabee told the crowd. "Every one of us will have to decide whether we want to keep this great country or whether we want to surrender and sacrifice it to tyranny."
Let me go to jail, Huckabee continued, because I'm the only one here… Not that it's about me. It's totally about keeping the gays from getting married.
Pay no attention to the pasty white bigot shrouded behind my loyal apostle! I'm the bigot you're looking for!
… Oh and also that lady, Kim whatshername? Davids? Davis?
Like the Bible says, and Mike Huckabee well knows…
Do nothing from rivalry or conceit, but in humility count others more significant than yourselves. Let each of you look not only to his own interests, but also to the interests of others. Have this mind among yourselves, which is yours in Christ Jesus…
…but if you need to get some votes because you're polling at like 2% in the US Presidential election, seriously, F#@% those other guys.
– Phillipians 2:1-10
And as the Bible also says, and Mike Huckabee well knows…
If I alone bear witness about myself, my testimony is not deemed true…
…but if you're really smart about what Jesus thinks about the US Constitution, then you should talk about how smart you are.
– John 5:31
God. Guns. Grits. Gravy. Gays.
Definitely no gays.
While President OBAMA was playing politics, George W. BUSH, the interpretive dancer and former president, came out of hiding today for an appearance to commemorate the BIGGEST F#@%ING "MISSION ACCOMPLISHED" OF HIS PRESIDENCY, Hurricane Katrina.
Welcome to This Old House with Donald Trump.
This week, we'll learn how to build a 30-foot, 40-foot, or even 50-foot, anti-rapist wall with just a few pieces of pre-cast plank and a hefty dose of bigotry…
This is one church Satan won't be messing with… Continue reading
Rand Paul tryed to take it to the DONALD this week, with a new YouTube video designed to protray him as a Demacrat (He's late to the party by the way, I wrote about how TRUMP was a doubble agent months ago).


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The McArthur laboratory investigates oncogenes as therapeutic targets for cancer.
By targeting oncogenic signalling in cancer and understanding the impact of this therapy on both the tumour cell and its microenvironment, we aim to develop novel treatment strategies that are durable and prevent therapy resistance. The McArthur laboratory has a specific interest in melanoma, but also investigates pancreatic and oesophageal cancer.
Major themes include:
- Defining the molecular events underpinning targeted therapy response, tolerance and resistance.
- Role of cellular metabolism in the response to targeted and immune therapies
- Immunobiology of melanoma
- Translating our pre-clinical studies into clinical trials
Research projects
Targeting CDK4 in melanoma
Melanoma treatment is undergoing a fundamental change due to the success of both BRAF targeted and immune therapies; however, both have their limitations. Typically, targeted therapies are associated with short-term responses due to acquisition of therapy resistance in patients; in contrast, immunotherapies have a lower patient response rate, but have long-term responses.
In preclinical studies using melanoma cell lines and in vivo models, we have demonstrated remarkably prolonged responses to a combination of targeted inhibitors to mutant BRAF and CDK4. We are now investigating how the combination of BRAF/MEK/ERK and CDK4 inhibitors induce durable responses. Furthermore, we are investigating the potential mechanism behind the development of resistance to each of these therapies. Understanding mechanisms of resistance is now an essential part of targeted therapy development, as it can provide both a biomarker for early detection of treatment failure and options for alternative subsequent treatments.
Targeting PRMT5 in CDK4 driven cancer
We have recently identified Protein Arginine Methyltransferase 5 (PRMT5) as a potential new target for CDK4 driven cancers including melanoma, pancreatic and oesophageal cancer. PRMT5 through methylation of histones and many other proteins regulates a diverse array of cellular functions and its activity is regulated by CDK4.
Our preclinical studies have identified novel PRMT5 inhibitor combinational therapies that are effective in pre-clinical CDK4 driven cancer models. Using both genomic and proteomic approaches we aim to identify potential downstream targets and pathways that are required for sensitivity to PRMT5 inhibitors and thus potential biomarkers of sensitivity and mechanisms of resistance to this class of inhibitor. In addition, a comparison across melanoma, pancreatic and oesophageal cancer cell lines will provide insight into common and likely fundamental mediators involved in PRMT5 signalling and also those that are unique to each cancer type.
Metabolic reprogramming in BRAF mutant melanoma
Metabolic reprogramming is a recognised hallmark of cancer. To support continued proliferation and growth, tumour cells must metabolically adapt to balance their bioenergetic and biosynthetic needs. To achieve this, cancer cells switch from mitochondrial oxidative phosphorylation to predominantly rely on glycolysis, a process known as the Warburg effect. The BRAF oncogene, mutated in approximately 50 per cent of melanoma patients, has recently emerged as a critical regulator of this process, bringing to the fore the importance of metabolic reprogramming in the pathogenesis and treatment of melanoma.
To further explore regulation of glycolysis by BRAF, we have performed a genome-wide RNAi screen. This approach has identified a network of novel protein complexes and pathways that may play a role in coupling oncogenic BRAF signalling to metabolic reprogramming. Significantly, depletion of components of this network specifically synergise with vemurafenib to potently suppress glycolysis and survival. These novel regulators of BRAF-driven metabolic reprogramming are under further investigation, using metabolomics and Seahorse Extracellular Flux analysis, for their potential as therapeutic targets in the context of BRAF-mutant melanoma.
Impact of targeted therapy on the tumour immune microenvironment
Melanoma is considered highly immunogenic but has evolved mechanisms that disable immune recognition and attack. Many small molecule inhibitors including BRAF, MEK and CDK4 inhibitors affect the tumour immune microenvironment, either promoting or diminishing the anti-tumour immune response. Understanding the impact of targeted therapy on both tumour immunogenicity and directly on immune cells is essential in advancing these agents, as well as their combination with immune therapies, into the clinic.
Using human melanoma cell lines, in vivo mouse models and patient samples, we are currently investigating the direct effect of targeted therapies on immune cell function and tumour immunogenicity. To do this we are using a variety of techniques including single cell RNA sequencing, flow cytometry and multiplex immunohistochemistry. In addition, we are assessing how these targeted therapies can be successfully combined with immune therapies to sustain tumour regression.
Key publications
AbuHammad S, Cullinane C, Martin C, Bacolas Z, Ward T, Chen H, Slater A, Ardley K, Kirby L, Chan KT, Brajanovski N, Smith LK, Rao AD, Lelliott EJ, Kleinschmidt M, Vergara IA, Papenfuss AT, Lau P, Ghosh P, Haupt S, Haupt Y, Sanij E, Poortinga G, Pearson RB, Falk H, Curtis DJ, Stupple P, Devlin M, Street I, Davies MA, McArthur GA, Sheppard KE. Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma Proc Natl Acad Sci USA. 2019 Sep 3;116 (36): 17990-18000. doi: 10.1073/ pnas.190132311
Lelliott EJ, Cullinane C, Martin CA, Walker R, Ramsbottom KM, Souza-Fonseca-Guimaraes F, Abuhammad S, Michie J, Kirby L, Young RJ, Slater A, Lau P, Meeth K, Oliaro J, Haynes N, McArthur GA, Sheppard KE (2019). A novel immunogenic mouse model of melanoma for the preclinical assessment of combination targeted and immune-based therapy. Scientific Reports. 9(1):1225
Martin CA, Cullinane C, Kirby L, Abuhammad S, Lelliott EJ, Waldeck K, Young RJ, Brajanovski N, Cameron DP, Walker R, Sanij E, Poortinga G, Hannan RD, Pearson RB, Hicks RJ, McArthur GA, Sheppard KE (2018). Palbociclib synergizes with BRAF and MEK inhibitors in treatment naïve melanoma but not after the development of BRAF inhibitor resistance. Int J Cancer.142(10):2139-2152.
Long GV, Atkinson V, Lo S, Sandhu S, Guminski AD, Brown MP, Wilmott JS, Edwards J, Gonzalez M, Scolyer RA, Menzies AM, McArthur GA (2018). Combination nivolumab and ipilimumab or nivolumab alone in melanoma brain metastases: a multicentre randomised phase 2 study. Lancet Oncol.19(5):672-681.
Parmenter TJ, Kleinschmidt M, Kinross KM, Bond ST, Li J, Kaadige MR, Rao A, KE Sheppard, Hugo W, Pupo GM, Pearson RB, McGee SL, Long GV, Scolyer RA, Rizos H, Lo RS, Cullinane C, Ayer DE, Ribas A, Johnstone RW, Hicks RJ, McArthur GA (2014). Response of BRAF mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discov. 4(4):423-33.
Young RJ, Waldeck K, Martin C, Foo JH, Cameron DP, Kirby L, Do H, Mitchell C, Cullinane C, Liu W, Fox SB, Dutton-Regester K, Hayward NK, Jene N, Dobrovic A, Pearson RB, Christensen JG, Randolph S, McArthur GA, Sheppard KE (2014). Loss of CDKN2A expression is a frequent event in primary invasive melanoma and correlates with sensitivity to the CDK4/6 inhibitor PD0332991 in melanoma cell lines. Pigment Cell Melanoma Res. 27(4):590–600.
Ribas A, Gonzalez R, Pavlick A, Hamid O, Gajewski TF, Daud A, Flaherty L, Logan T, Chmielowski B, Lewis K, Kee D, Boasberg P, Yin M, Chan I, Musib L, Choong N, Puzanov I, McArthur GA (2014). Combination of vemurafenib and cobimetinib in patients with advanced BRAFV600-mutated melanoma: a phase 1b study.
Lancet Oncol. 15(9):954-65.
Mar VJ, Wong SQ, Li J, Scolyer RA, McLean C, Papenfuss AT, Tothill RW, Kakavand H, Mann GJ, Thompson JF, Behren A, Cebon JS, Wolfe R, Kelly JW, Dobrovic A, McArthur GA (2013). BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage.
Clin Cancer Res.19(17):4589-98.

subset: commoncrawl


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The week before the surgery I kept having horrible dreams. In each dream I handed Zac off to the nurses and then waited & waited. Each dream ended with a doctor (not our doctor, a different one) coming out of the operating room and saying, "We're having trouble bringing him out of anesthesia." Then I would jolt awake. They were definitely disconcerting dreams but I chalked them up to being a worry wart.
We arrived at the hospital on the day of the surgery super early. We left our house at 4 AM - surgery was scheduled for 7:30 AM but we had to be there at 6 AM. The anesthesiologist came in and talked to us, the surgeon came in and talked to us, and the surgery nurses came in to introduce themselves and take him back to get all the pre-op stuff started. I don't know that I can accurately describe how horrible it feels to kiss your baby, hand them off to a nurse, and watch them walk away. I don't know how parents whose children have to have multiple surgeries do it. I know there's so many more horrible feelings in the world and that it was a just a routine surgery, blah blah blah...but I still felt a terrible sinking feeling, and a desperate urge to run after them and grab him back. The doctor reassured me and told me he would take the best care of him, and I knew he would. He is seriously the most confident man I have ever met and there is no one else I would rather having operating on my sons.
My husband and I went downstairs and got some breakfast while we were waiting and then headed back to the surgery waiting area. We played on our phones, talked quietly, and glared at the constantly running fountain that incited bathroom visits. An hour or so after he was taken back, the surgeon came out and said that everything went great. He said that they would come out and get us in five minutes or so and then we could go see him. I was insanely relieved. My dream was just a big bunch of worrying for nothing.
Minutes ticked by. Ten minutes, twenty minutes, a half hour. My husband said, "Do you think they forgot about us?" An emergency code was called over the intercom and that was a little frightening sounding, but as far as we could tell it was in a room on the other side of the hospital. Almost forty five minutes had passed and I was beginning to feel panicky. Our doctor came out again and said, "Did they already come out and talk to you? They had some issues when they took him off the anesthesia." (At this point, I was like five seconds from bolting back to his room.) He went on to say that when they took all the breathing equipment out, Zac had some respiratory issues - he'd started coughing & gagging and sounded croupy. They gave him a breathing treatment and a shot, so they wanted to observe him awhile longer but that we could now go back and see him.
We went into his room and he was sleeping on his side, all scrunched up into the corner of the bed. I climbed in and picked him up. He was so groggy and out of it. He woke up a tiny bit here and there and nursed a little. The doctor, nurses, and anesthesiologist all came in to check on us. They talked briefly about keeping him overnight but his breathing improved greatly within an hour or two and we were finally free to go home.
They said to make him rest the remainder of the day and then take it easy for at least a week but you can't hardly keep this little guy down! I did make him rest and TRIED to get him to take it easy but now that he's walking there's almost no stopping him. He's recovering very well and has a check-up next week that should be a breeze! We received a nice little card from his nurses and the other staff this week wishing him a good recovery. I really appreciate all the thoughts & prayers everyone on Twitter & Facebook sent our way.


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Washington, D.C. — and the surrounding cities that comprise the DMV area — is a booming metropolis with incredible career opportunities.
Are you putting your best foot forward in your job search?
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Our list of the top 10 resume writers in DC is here to help you find a resume writing service that will show hiring managers just how marketable you are.
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Take a look at this list of the best of the best Washington resume writers, then prepare to take your job search to new heights.
Best Resume Services in Washington D.C.
If you are in a hurry and don't want to read our detailed reviews below, here is a list of the Best Resume Writers in Washington D.C.:
- Find My Profession
- Your Next Jump
- Your Edge for Success
- Liz Strom
- GPS Professional Coaching
- DMV Resume Services
- Klaxos
- Jim Weinstein
- Blueprintgreen Coaching & Consulting
And now for the detailed reviews...
1. Find My Profession
Find My Profession is not just a top-notch resume writing service in DC. We are a global company headquartered in the US on a mission to master effective, ATS compatible resumes that convert into offers.
A major perk of Find My Profession is that we are not a one-person shop.
Collectively, our team of elite resume writers has experience in 85+ unique industries/professions. This allows us to assign you a professional writer (in the United States) based on your unique background and experience.
We are also not a resume factory. We will never use "ghostwriters". You will have your resume writer's name, email, and phone number for direct communication.
With 100+ 5-star reviews and a 60-day interview guarantee that speaks for itself, you can sleep easy knowing that your satisfaction is our priority.
Pros: Find My Profession commits to working with each client until they are completely satisfied. Don't worry about having a limited number of edits, or a set amount of time with your writer.
Cons: Find My Profession is a virtual/online company. While we provide services in your city, we don't have a physical office. Also, with a focus on more senior positions, our entry-level resume service may be a bit pricey for recent graduates.
Turnaround: 3-5 business days. Can expedite to 2 business days.
Cost: $395-$895
Phone: (831) 888-0967
Check out some of our 5-star reviews.
2. Your Next Jump
Your Next Jump has staked a claim in the Washington D.C. resume writing services market, and rightfully so. As they clearly state on their website, employers spend 30 seconds (on average) looking at resumes. Is yours standing out? If not, you should consider a well-revered service like Your Next Jump.
Pros: In addition to the Certified Professional Resume Writers they have working on each resume, Your Next Jump also offers in-person consulting for career analysis, coaching, and even assistance with building an online presence on platforms like LinkedIn.
Cons: Their services may be on the higher-end (price wise) when compared to some other DC resume writers, but the all-inclusive career launch kit that offers resume writing comes with added bonuses — like job search coaching and online presence building.
Turnaround: Not stated.
Cost: $749
Phone: Not stated.
3. Your Edge for Success/YES
Your Edge for Success (YES) snags the fourth spot on our list. With their slew of good ratings and their years of experience in the metro-Washington area, YES is a worthy D.C. resume writing service. In addition to writing resumes, YES also offers interview coaching, LinkedIn profile updates, job transition services, and business coaching.
Pros: They're a decade old, so they have a history in the industry. Founder Katherine Metres Akbar is an author who has received press for her tips on writing great resumes.
Cons: Their website might not be the sleekest, but don't let that dissuade you. Their service surely is.
Turnaround: 5 business days after gathering necessary information.
Cost: $299 for a traditional resume. $499 for a federal resume.
Phone number: (202) 740-3032
4. Liz Strom
Liz Strom, also known as "The Life Coach" for Washington DC, is not only known for her life coaching, but her career coaching as well. Liz has received local attention, allowing her to promote her company's "energy-shifting life coaching & workshops" throughout the D.C. area.
Pros: If you're in need of additional services besides resume writing, her life and career coaching services may be of use to you. You can get all of the help you need in one place. And even if you are in fact just focused on resume writing, she has applicable services to go along with your resume, like new cover letters.
Cons: As a one woman show, she's likely to get booked up from time to time. Hop right on ordering your resume if you're using her service.
Turnaround: 3-5 business days. $100 upcharge for 48-hour (or less) delivery.
Cost: $200-$400
Phone number: (765) 400-1177
5. GPS Professional Coaching
GPS Professional Coaching aims to make your career objectives attainable. Tired of getting passed over for promotions? Looking to take your career to the next level? Need to figure out why you can't get hired? These are all core competencies that GPS Professional Coaching uses to best service their clients.
Pros: 5-star reviews from past clients point to proven success with their resume writing services. They are known for their cover letter writing skills as well.
Cons: Prepare to pick up the phone. With critical details regarding pricing and timeline left off the website, you've got to reach out directly in order to take the first steps.
Turnaround: Not stated.
Cost: Not stated.
Phone number: (571) 357-4771
6. DMV Resume Services
DMV Resume Services is not part of the Department of Motor Vehicles, although their name might lead you to think otherwise. Anyone from D.C. knows that DMV includes D.C., Maryland, and Virginia. Ms. Kim Love is the owner and writer for DMV Resume Services, and she puts care into every single resume that she writes. Kim has been writing resumes since 2008 and has clearly put in the hours to hone her resume writing abilities.
Pros: DMV Resume Services is one of the few resume writing services that offer a 4-hour turnaround time. There are few resume services that can compete with that time. There are a ton of inspiring Facebook reviews that could convince you to opt for Ms. Kim's services.
Cons: DMV Resume Services can end up costing you over $1,000 if you need a great resume right away. Kim is the only resume writer at DMV Resume Services, which could be an issue if she is not available that day for a rush resume.
Turnaround: 3-5 business days. 4-hour rush service is available.
Cost: $149 - $1219
Phone number: (240) 441-9899
7. Klaxos
Klaxos has built a reputation based on knowing "what recruiters want." Naturally, all great resume writing services should have those skills, and Klaxos is no different. They offer Washington, D.C. resume writing services that are backed up by an awesome reputation in the DMV area.
Pros: They boast former clients who have gone on to work at eBay and ESPN, which means you can trust the expertise of their D.C. resume writers. Not to mention, the ability to get a simple resume review is a reasonably priced option if you don't think your resume needs a total overhaul.
Cons: Some of their most useful packages are priced higher than competitors in the D.C. area.
Turnaround: 4 business days.
Cost: $399-$949. However, a more affordable option is available. Phone consultation, career review, and resume review (not writing) is available for $150.
Phone number: (703) 679-7719
8. Jim Weinstein
Jim Weinstein is a career coach not only with a Harvard MBA but with over two decades of experience as both a business executive and a licensed psychotherapist. Impressive, right? It's this variety of education, experience, and skill that has landed him firmly on our list of the top 10 resume writers that Washington, D.C. has to offer.
Pros: Jim's experience as a psychotherapist can give him a leg up in working through what people are thinking and how to best position yourself for success. This background and knowledge make him a solid (albeit unique) option for a D.C. resume writer. After all, it's not often that you come across a resume writer who is also a psychotherapist. Who knows? You might learn something new about yourself in the process of working with Jim.
Cons: Jim bases his resume writing costs based on how many sessions it takes to get things fleshed out. This could be a major con if you're looking for a flat rate DC resume writing service.
Turnaround: 2-3 sessions.
Cost: $400+
Phone number: (202) 706-3788
9. Blueprintgreen Coaching & Consulting
Blueprintgreen Coaching & Consulting has an inspiring mission statement; "we help professionals break free from toxic work environments and transition into meaningful work that they love." Noble, right? If this sounds like your desired approach to improving your resume (and overall career path), you should consider this top 10 service.
Pros: Chrissy Macken is a woman on a mission. She is involved in quite a few noble social and environmental initiatives, which is a major plus for you if you like supporting companies that may align with your personal values.
Cons: If you want a straight-to-the-point resume writing service — and not all-around career coaching — your needs will be better met by a company that specifically and exclusively handles D.C. resume writing.
Turnaround: Not stated.
Cost: Not stated.
Phone number: (301) 244-8063
This List Serves The Following Areas Near Washington, District of Columbia:
Hyattsville, Rockville, Gaithersburg, College Park, New Carrollton, Bowie, Frederick, and more.


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Saturday, November 2, 2013
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If you have the desire to own a home, there are thousands of programs available that will help you accomplish the American Dream. Owning a home is one of the best investments that you can make. Home ownership is like having money in the bank. Owning your own home will give you tremendous bargaining power and great net worth. The major fear that most people encounter when trying to purchase a home is financing. Some people believe that home ownership is impossible for them because they have challenged credit.However, this is not true. You can still become a home owner by using creative financing resources. Creative financing programs offer people with credit issues such as bankruptcies, foreclosures, repossessions, charge-offs, late payments, judgement, liens, medical bills, student loans, and low income achieve home ownership. American citizens have been crippled over the past years by the issues listed above. Home ownership does not have to be impossible. It is important that you invest in a home now since mortgage rates continue to rise. Mortgage companies are eager for your business and many of them have finance programs that will help individual qualify for the home of their dreams.For more information visit - [http://cassycare.com]
Posted by Unknown at 11:46 PM
Labels: Finance


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January 08, 2008
Adobe and Omniture: Further details
As promised last week, a number of Adobe folks have been gathering information about Adobe desktop applications' communications with a server named "192.168.112.2o7.net," operated by Web analytics firm Omniture. Having already discussed what data is (and is not) being gathered and tracked, let's talk about the history & purpose of the implementation.
The welcome screen (screenshot) that's available in some Adobe CS3 applications (Flash, Fireworks, Dreamweaver, Illustrator, and InDesign) is designed to show fresh, relevant news and information. For that reason it loads a Flash SWF file that's hosted on Adobe.com, just as a Web browser would do. When the SWF gets loaded, it pings the Omniture server to record the event. As noted previously, no personal information is uploaded in that exchange.
Some questions & answers:
Q.: Why does the SWF fetched into the welcome screen call the Omniture server?
A.: All of the content fetched from Adobe.com does this. Adobe, like almost all companies with a Web presence, anonymously tracks usage patterns and response-time statistics. The only way to get effective data on this is to use client-side callbacks, and Adobe works with Omniture to do this. Hence the call to the Omniture server.
Q.: Why does Adobe use a server whose name is so suspicious-looking?
A.: I'm afraid the answer is that we don't really know. The fact is that this SWF tracking code already existed on the Macromedia side at the time the companies merged, and it was adopted without change by a number of products for CS3. The people who wrote the code originally did not document why they used that server name, and we can't find anyone who remembers. I'm sorry we aren't able to provide a more solid, definitive explanation.
Q.: Follow-on: Given that you can't give a good reason why Adobe is using a server whose name is so suspicious, are you going to change the name?
A.: Absolutely. We are working with Omniture on this right now, and will make this change as soon as we can. (I don't know how long this will take, but will post here when I do.)
Longer-term (in future releases), we'll do a better job of explaining what the apps are doing of the network and why. I think we can enable some really amazing user experiences by bringing the desktop & online worlds closer together, and that most people will want to participate in those. The key thing is that they be given the choice, and that they be made aware of what's going on.
Does that make sense? All in all, I'm glad that people raised the issue; that we can explain what Adobe apps are doing; and that we can bear this experience in mind as we move forward.
PS–A tech note is now live on Adobe.com, detailing the way the apps interact with the 2O7.net server.
So based on that I guess if you choose to not display the welcome screen in the applications then the server would not be called?
[That's correct. –J.]
You guys are the best company in the world. But you probably already knew that :)
With the current state of mega-corporations, it's just amazing to see a company take such swift, clearly explained, apologetic, correcting actions simply because their users pointed something out.
Hat's off to you, John, for spearheading this particular effort, and in general for always braving the full brunt of user opinions right here in public. It can't be easy!
When you are looking at addressing how your apps work accross the network, can you take into account that some of us use your products in a corporate enviroment. Activating and registering them via the web is not possible becuase your applicaitons do not support proxy servers on Windows. And we are required to use the corporate proxy server. There is no exceptions, and no options other than calling each time we want to reregister and move stuff.
Okay, so I appreciate the technote and the comments above. I can also accept and take your word for the thing about "no one remembers". Man, if someone had to look at code I did 5 years ago I wouldn't envy them. And… since you agree it's a less than desirable subdomain and plan to fix it–that's great.
One thing that might be worth noting is that while the "get fresh content" feature of the start page is of debatable value (frankly 99% of the time it says "hey, you want to buy something?")… the option to turn it off in order to block the server calls also coincides with disabling the (arguably) real value of the start page. That is, I like the start page… but I'm indifferent to the fresh content. My choice is to live without the start page or accept the tracking. Naturally, the option to independently turn one off and not the other is something to add in the next round of improvements. In fact there could be THREE options:
–start page on/off
–get fresh .swf content/ads
–track my usage to make product better.
Finally, and maybe I'm just naturally argumentative… but I am curious how does knowing what apps I launch help improve the product? I'm not saying it doesn't but from a statistical perspective it doesn't seem like a great value.
Anyway, thanks for sticking with this and I think it's a fair expectation that you'll have placated most people on this issue.
Oh, how good does it feel to see someone simply say "I don't know" instead of making up some phony excuse that doesn't help anyone. Nice! :-)
Thanks for the research, regular updates, and explanation. We'll have to start calling you the Omnipotent Omniture Ombudsman, so to speak.
Of course, viewing that technote causes your browser to send information about all your loaded plugins to Omniture. (Again, Safari activity window)
Kudos to you for the swift action John!
The software has being doing this for 5 years, and it's not been a secret all this time. Suddenly the sky is falling.
OK it's good to see Adobe being reactive, but the uproar from the user base is 5 years too late.
Great follow-up Mr. Nack. You are an exceptional voice of transparency for such a large and ominous company.
just… why 192.168.112.2o7.net instead of dunno, adobefreshandrelevantnews.com?
I mean, sorry but it doesn't smell OK…
[That's what I'm saying above: the current URL sends the wrong message, and it'll be changed. –J.]
If you don't like the start page, you can always create your own.
So why was the welcome screen omitted from Photoshop? It just seems inconsistent.
[You're right, and it is. We simply ran out of time. –J.]
Here's my update:
John – have a read please as I thank you in my post. While I don't agree 100% with the outcome, you went above and beyond, especially during a holiday, to help. You should be thanked.
[Thanks for the link, Allen. I'm on the road at the moment (hence the delayed responses), but I'll check it out shortly. –J.]
Is it REALLY that important to force ads into the welcome screens?
[The SWF isn't an ad. Customers have frequently complained that they don't know where to go to find news and resources about Adobe products. The SWF is meant to provide links & news. It's one of many efforts to help people get more value from the products they've purchased. –J.]
I've already bought the product, can't you pleeeeze be satisfied with that and stop trying to somehow pry additional pennies out of me while I'm using the application that I've already bought? Sounds like one of those "clever" ideas that the marketing department thought up and that was reluctantly implemented by the engineers. Years later, the plan hasn't produced a nickle (I would guess) and instead had resulted in a huge black eye for — wait for it — the engineers!
[Yes, it's always villainous "marketing" screwing up the works… :-P –J.]
Runs to buy Little Snitch.
I'm glad that Adobe finally took the issue seriously enough to come up with a response, but it's a little frustrating that it required eight months (http://blogs.adobe.com/jnack/2007/01/cs3_doesnt_inst.html#c326034) and a huge uproar. It may not have been a "secret" over the past five years, but you can hardly expect the average user to have known about it before now. Most folks don't actively monitor outbound network traffic from their desktops, and wouldn't know what to do with the information if they did. Now with Vista, it's pretty hard to miss.
This was the electronic equivalent of coming home to find some guy wearing a ski mask in your kitchen. If you prefer to assume he's an invited guest and offer the fella a drink and some light conversation … well, it's your house and that's your prerogative. If it happens in my house I'm dialing 911 and letting the cops sort it out.
The ski mask thing…
It's really not. You're way over the top there. It's an interesting metaphor, but, a splash screen on a piece of graphics software phoning home has no resemblance to an intruder wearing a balaclava. None. Not at all.
Not saying Macromedia were right, but… keep the ball on the deck , will ya!
This is absurd. "We really don't know" is not answer. It's your app, controlled by your employees… find out. You can't in one breath say it's performing a useful function by serving the latest updates, and then right after say you don't know how it got there. There's only one reason to name a server that, and I don't think it's Adobe's attempt at an ironic joke. It is to allude detection, and now that they've been caught it begs the question, why were you trying to avoid detection? "I don't know" is a pathetic response.
Even though this all turns out to be "innocent" there are a couple of concerns:
Why did Adobe ever put this in in the first place? Why did they feel the need to know about how I use the product (even in anonymous aggregate.) You DON'T need client side callbacks. You claim the information helps you understand the product usage and then tell us that it is not collecting any serious information. Which is it? Why did Adobe try to hide it by using an internal network type IP?
[As mentioned, the server naming decision was made at Macromedia pre-merger, and I haven't been able to get a good answer as to why it was made. –J.]
Why am I not notified of it right up front?
[As I've been trying to say, I think we should do a better job of communicating about what's happening & giving people control over it. –J.]
Why am I not given a way to turn it off?
[I'm not sure why people keep saying that they're not given a way to opt out of this. You can simply choose not to show the welcome screen, in which case it won't load, display the SWF, and ping the server. –J.]
Who is compiling the final product? Even your top guys had to research this so one has to wonder what other things are in Adobe's software the we are not aware of yet?
Listen Adobe!
Since the switch from Golive to Dreamweaver, I don't trust you anymore! Once you blamed Dreamweaver!! That is what I remember very well!!!!
Most customers are suffering from amnesia, but I don't!
ADOBE your management is equal to M$. Buy drestroy and misuse your marketingpower.
Shame on you!
A pathetic response is better than a dishonest one.
"… The key thing is that they be given the choice, and that they be made aware of what's going on. …"
Actually, no it isn't. The key is that users be given said choice before the software initiates any kind of network connection, anything else is plain and simply unacceptable.
I'm happy to see that, through your efforts John, Adobe finally took serious notice of a decidedly suspicious domain name, and decided to change that name. Unfortunately, before your involvement, Adobe apparently didn't take users' concerns about this name seriously, as the issue was first raised and brought to Adobe's attention many months ago. Sadly, it seems that a couple of "sky-is-falling" blogs were required to get the name changed.
I would add that, as a user, I welcome and appreciate informative opt-in (or opt-out) questions regarding application behaviour (and particularly non-obvious behaviour). Other than for apps whose primary purpose is to connect to the net, I consider an application's attempt to connect to an internet server to be 'non-obvious' behaviour.
The one inconsistency here that has been brought up, but skipped over in your replies is the question about how it can be improving the software if it's not really sending any important data.
Can you detail exactly how this process works?
1.What is the information that is collected.
2. How is it used to improve the app?
The world would be a better place if Flash did not exist.
Sigh, I guess some people's reading comprehension isn't as good as others. Mark Twain must have had you in mind when he wrote:
"A man who carries a cat by the tail learns something he can learn in no other way."
Phoning home in any manner without PRIOR permission is unacceptable in any and all cases.
If this is truly a "feature" that users want, then an opt-IN setting that could be enabled when the app is first booted would work without any backlash or invasiveness and still give everyone what they want.
I am not sure if this has been addressed yet, but I will venture a guess as to why the name 192.168.112.2o7.net was used.
192.168.X.X are numbers used on internal networks, and are not routed on the Web. Note that when you boot up the new router on your home network, 192.168.1.X series of addresses are used by default. You can learn more about network address translation (NAT) here http://www.openbsd.org/faq/pf/nat.html
If someone quickly looks at the address 192.168.112.2o7.net it appears to be a device on the network and won't be investigated as much as say ServerThatCollectsYourData.com. If this is correct, this seems to be a little on the sneaky side to me.
My 2 cents.
John – I do appreciate that you took the time to investigate this matter and were willing to say I don't know.
here are two solutions while we wait for adobe to discover why the code they themselves wrote contains what it does
First off, I think this is all a bunch of baloney. The lame explanation simply proves you can't trust Adobe.
I think Adobe knew exactly what it was doing, and consciously decided to abuse users trust with ready made trouble management set in place complete with lame answers.
Users should be weary and acquire good software firewalls.
I kind of wonder what else they are doing, since while using MY PURCHASED copy of Illustrator CS2, I get popups telling me about CS3. I am definitely getting rid of this spyware!
[First I've heard of it. Where in CS2 are you seeing such popups? –J.]
I'm going to start a class action suit. Watch the news…
Guys, the 188.8.131.52o7.net is not an "Adobe spy" domain, that all, is just a Sub-dmomain of the 2o7.net domain, and is used by Omniture for tracking, in a 3rd party cookies mode, Omniture has a solution to this "problem" wich requires some DNS configurations, so this way Adobe will be able to use something like metrics.adobe.com instead 126.96.36.199o7.net, im sure they are working on it.
@ Billy: You are right thus. Adobe would exactly have to know what does it there. I already know why I the welcome screen never use.
Bravo! Two years later (2010) Adobe CS4 applications still try connecting to 192.168.112.2O7.net.
So much for the last answer in this post:
"Absolutely. We are working with Omniture on this right now, and will make this change as soon as we can. "
Shame on Adobe. :(
"as soon as we can"
One would have thought 'never' and 'soon' would be mutually exclusive
Where can I download the adobe-dictionary?


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Took my youngest to RAF Leuchars yesterday, the weather was abissmal, but we had a good day out. the flying programme was all cut due to the low cloud, overcast at 400 feet and visibility was down to 2000 metres at some points
It nearly took me as long to get out of the car park as what it did to get back home , they were estimating 40000 visitors, mainly due to that this is the first display in 2 years and the fact that the avro vulcan was there, unfortunately that was a major casualty to the weather also and never flew.
There was however some excitement with a role demo from 2 GR4 tornado's and when the red arrows went through, noisest was the Eurofighter, but he too had to call it short because of the weather.


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HP Slate in extremely controlled demonstrations and cheesy videos until now, but it looks like the Windows 7 tablet just spent a little bit of time in the wild -- Conecti.ca's posted up a full hands-on and mini-review. Their conclusion? "The official verdict is meh." Yeah, ouch. Apparently the Slate's biggest strength is also its greatest weakness -- it's essentially a touchscreen netbook, and that means that while it can run everything including Flash, it can be "slow and annoying." Unfortunately there's not a lot of info on how well HP's TouchSmart Windows 7 skin works, so we'll wait till we play with one before we make a decision, but man -- we definitely weren't expecting this thing to look so chunky in the photos. No wonder the press pics and other demos are so carefully arranged -- it really does look like a chopped up netbook. At least the HDMI dock is somewhat sexy, we suppose. Couple more pics after the break.
[Thanks, WikiWarrior]


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Submitted by Mortal Mindy on
With the General and local elections less than three weeks away, politics may seem to some to be the overwhelming factor. Yesterday it was suggested that the Potash Mine would be approved under a Labour Government? Erm, no it would depend on 'currency'. Eh? Erm, how to explain ... power is not all about politics, but, sticking to the suggested 'jobs?' - Yep, reply "jobs, resources, etc whatever exchange is considered most important - wouldn't worry too much - wiser heads than ours :-)
The forthcoming R&CBC decision on the York Potash mine is looming, this week, Thursday. It would seem logical once this decision has been made then the NYMNPA would be able to put forward its Agenda and decision date ...This R&CBC decision is imo the 'biggie' - its about the transport system, if you can't get the stuff out of the Park, safely and efficiently, then there is no need for a mine. The R&CBC recommendation is for APPROVAL but it is up to the Members of the Regulatory Committee to make that final decision. Foregoing the fact this is Boulby's old stomping ground there are other factors at play. It may be understandable to believe that this is a political decision, and note that Bingo Bob did indeed rally ALL of the political groups to co-sign a letter in support of this project.
Just to clarify there are 3 people allowed to speak for and against at R&CBC : http://www.redcar-cleveland.gov.uk/rcbcweb.nsf/BC9224DF7DCFD54A80256FF00...$FILE/Attendance%20and%20Public%20Speaking%20at%20Committee.pdf - I am very curious to know who these will be, but am 99% certain they will not be politicans.
Regardless, back to the politics and 'currency'. Politics is about perception. What is seen. Behind the scenes ... who knows? That is what I meant by currency. Policys are usually formed by the knowedgable and experienced, to be adopted by politcal groups as their manifesto, agenda. The fact that some of these politicians (decision makers) fail to understand or comprehend the basics is by and by. They are the public face, the front and the media fodder should they fail to deliver.
So, politics is only a part of the 'power' mix. Perhaps my term 'currency' could be misconstrued with 'money'. A dirty word ? Not so, it is important to everyone and allows people to trade. Usually an exchange for mutual benefit, otherwise its considered criminal. Perceptions vary but commonly cold hard cash is often considered the politicians, erm, exit.
So, lets exhange the word 'money' for 'commodity'. The commoditys market. Basically, the 'bread and butter', the grains, wheat, corn, rice, coffee, sugar the basics needed to sustain and nourish humanity. Also the oil, gas, coal, timber- the energy market. Far more exciting and interesting than the banking industry, its where the real money's at. It is the money that follows the commodity. Topical commodites - the energy we consume have been hyped by the media under the 'fracking' label. Into all of this we can throw in technology, the science, research and development - to ease the flow of commodites.
However, to continue the analogy on 'currency' there is also another important factor - the social. What is important to people? Is it topical? And this is where the politicians come in to sway public opinion - well the good ones (and they don't seem to be that many). To pin point, (I'd rather stick pins in my eyes) over the R&CBC decision on the Potash Project - it is in my humbly bumbly - futile. The commodity or product, is sold.
That, imho, is the beauty of the York Potash Project - it feeds into global basic human needs. The term 'currency' may have been misconstrued but I considered it worthwhile to explain. (I don't understand Twitter!!)
It goes above and beyond the 'local' and fits into the 'global' perspective ... apart from which lifes too short to keep explaining
Perhaps an example on 'currency' and the powers that be would be more useful, (tho perhaps not a very good one, hey ho) hmmm ... Stargate to Japan - a far flung place of mystique - beyond my horizons, but certainly current, along with an expected ripple :-)
via Wolf: http://wolfstreet.com/2015/04/14/japan-may-not-restart-nukes-after-all/
Hmmm, still confused? - ok let me sum up in a few short words. 'Its not about us, its about them.' - (and I don't mean Japan, York Potash, Boulby, Sabic, R&CBC, NYMNPA etc etc) ...
All in my humbly bumbly - but if you ask me a daft question expect an answer. Not necessarily short & sweet ...
ps; on a lighter note or beyond the pale - is this for real? WTFDIK ... passengers ...
9 Comments
Currency - National Grid
Submitted by Mortal Mindy on
Tonights headlines 'News' - the National Grid hopes to power up Whitby via Malton ...
the extreme lengths some folk will go to .... hmmm
"the work is complicated by the fact that around 60 per cent of the cable route is located within the North York Moors Special Area of conservation and North York Moors Special Protection Area."
Hmm - they kept that quiet, just in case ;-) M
"More than 100 pylons will be pulled down and 20km of underground cable installed as part of a multi-million pound overhaul of the electricity network between Malton and Whitby.
Northern Powergrid says its ambitious £18 million project, which starts this week, will improve the quality and reliability of electricity for thousands of local people.
As part of the replacement of the existing overhead power lines, 20kms of underground cable will be installed along the A169 through the North York Moors National Park and 108 towers dismantled - also helping ti improve the views across the outstanding area of natural beauty.
However, the work is complicated by the fact that around 60 per cent of the cable route is located within the North York Moors Special Area of conservation and North York Moors Special Protection Area.
The area is protected due to the presence of rare and vulnerable habitat including dry heath, wet heath and blanket bog. It is also home to a large number of species of importance including breeding Golden Plover, Merlin, Short-eared Owl, Peregrine Falcon, Hen Harrier, Redshank and Curlew.
Northern Powergrid has employed ecological consultants from ADAS UK Ltd and liaised closely with Natural England and The North York Moors National Park to try and avoid any significant disturbance to important habitats and species as well as the wider environment.
It has also worked with the local authority to ensure traffic management is managed as effectively as possible to minimise disruption for residents and tourists as much as possible. There are also no plans to disrupt customers' electricity supplies during the work.
Carl Bandeira, Northern Powergrid's project manager, said: "This is a major investment by Northern Powergrid in both the reliability of the power supply between Malton and Whitby for local residents and enhancing the beautiful natural landscape of the North York Moor National Park for the future.
"We'll continue to work with Natural England and The North York Moors National Park throughout the project to ensure this area of significant beauty and environmental importance is treated with the respect it deserves.
"Once we've completed installation of the underground cable network and carried out modification works at both Thornton Dale and Whitby substations, we will remove the 108 towers. This will help provide more uninterrupted, natural views for local people and tourists of the stunning scenery this moorland landscape is famous for."
"While we carry out this vital investment project there will be some disruption to traffic along the A169 between the Fox and Rabbit pub at Lockton and Blue Bank car parking areas at Sleights. We're making every effort to reduce the impact and keep residents and businesses informed of our progress."
Work is expected to be completed by October next year.
The first phase of the work began on the A169, north of the Fox and Rabbit pub, Lockton, on Monday. Some disruption is expected along the road between the pub and Blue Bank at Sleights.
Northern Powergrid say the project is expected to be completed by October next year."
Fox n Rabbit or the Hare n Hounds
Submitted by Captain Qahn on
Hmm - Carl Bandeira - he's a cutie - Electricity Alliance West
Nice map, Knapton?
cuts straight through the MoD Fylingdales, no where near the Mine.
too much info : to file: BGS : http://m.northyorks.gov.uk/CHttpHandler.ashx?id=27272&p=0
Could be fun : http://whitbyeskenergy.org.uk/wp-content/uploads/2014/08/Esk-Energy-annu...
one got missed: file: http://yorkpotash.co.uk/site/assets/files/2631/part_1_chapter_5_-_5_1_2_...
and finally, YP have it covered:-)
Late again - Ha! - https://www.youtube.com/watch?v=AMfE2Se4r9w
Deflation - Conflicting Views
Submitted by Mortal Mindy on
but all inc Japan:-)
Out of the EU? Economical with the truth ... how much has sterling devalued in the last five years ... Slasher economics ... Beano
25% since 2008 + 15% ? erm ... bollox ;-/ https://www.youtube.com/watch?v=Z0XLzIswI2s
Volcano too close to Power Plant?
Submitted by Mortal Mindy on
Enchancing ... pressure pot spills out
Eternal Flame
Submitted by Mortal Mindy on
Lock Awe
Cats n Goldfish ...
Founders Found
Submitted by Captain Qahn on
"The keys are inextricably linked to blocks of bitcoins known to have been created or "mined" by Satoshi Nakamoto.
"These are the blocks used to send 10 bitcoins to Hal Finney in January [2009] as the first bitcoin transaction," said Mr Wright during his demonstration."
Two Wrights didn't make a Wrong ...
:-) http://www.dailymail.co.uk/news/article-3568740/Captain-Cook-s-HMS-Endea...
'Whitby's Most Famous Wreck Found?'
Submitted by Benefitz Betty on
Ah, so
"6:31am 4th May 2016
We'll find out later today more about whether Captain Cook's Ship Endeavour has been found.
It was built in Whitby and launched in 1964.
The Rhode Island Marine Archaeology Project believes they've found the ships remains near Newport off the East Coast of America. They'll release more information about it this afternoon at around 3pm BST.
Doctor Sophie Forgan is the chairman of trustees at the Captain Cook Museum in Whitby. She said:
"When we see the full report and all the research then we'll be able to make a better judgement, but it's certainly a possibility (it is Endeavour). i think what really interests people is putting together pieces of the story. If they've found the actual ship that's tremendous and perhaps we might learn more about what happened to it after the voyages as well as what it was like on the voyages.
"I think people in Whitby will be fascinated and really interested and it's enabling us all to fill in more gaps in the story."
Starters for 10 ;-
An alternate reality : https://www.justgiving.com/ridethebos
EU: Currency & The Northern Power House
Submitted by Captain Qahn on
Digital exposure?
Could be some very 'full' ports ....
Ramble, Rumble, Ramboll ..
(interesting comment)
Ah,so ...
"Treasury analysis claims that by 2020 there will be at least 20,000 new jobs created in the North-East at current growth rates – but only on the proviso that Britain remains in the EU.
Not all the indicators are positive, however. According to the York-based Joseph Rowntree Foundation ten of the UK's top 12 poorest cities are based in the North.
The North also still has lower wages, lower productivity and a higher dependency on welfare than many other parts of the country.
Meanwhile, Ed Cox, the director of IPPR North, said the Government risks a "piecemeal" approach by not encouraging more involvement from business in the Northern Powerhouse and having a "proper plan".
Wot they don't have a proper plan?
Ironically, a flag for foreign LT investment in the UK
Banks, Bonds & Bounty ... TTIP the tip of the iceberg... or which way it falls. East or West.... but it sure won't be independence day.
EU: An English Civil War
Submitted by Benefitz Betty on
or Russian Roulette for Cambo?
Ah, so ... the Devil & Tom Walker....
Naval Gazing: Four non blondes ... Putin, Boris, Trump & that lass (but not least)


text:
Andy Manar is a state senator from Bunker Hill in southern Macoupin County. He represents the 48th Senate District, which stretches from the east side of Springfield to Decatur in the north, spanning south into Christian and Montgomery counties and portions of Macoupin and northern Madison counties.
Manar first was elected to the Illinois Senate in 2012. Before that he was Macoupin County Board chairman, mayor of Bunker Hill and a Bunker Hill city councilman. He graduated from Southern Illinois University Edwardsville with a degree in history with teacher certification.
Manar is a champion for fiscal responsibility, bipartisan cooperation and expanded voter access. In 2017 he successfully advanced a bipartisan measure to bring automatic voter registration to Illinois to modernize the process, streamline state government and save taxpayers money. The bill was signed into law Aug. 28.
Manar also was the driving force behind the successful movement to reform Illinois' worst-in-the-nation school funding formula. Since he became a state senator, he has been a tireless advocate for fair and adequate school funding that doesn't treat students differently based on ZIP codes. In 2017, he and State Representative Will Davis (D-Homewood) advanced a landmark school funding reform measure in the General Assembly, and it was signed into law Aug. 31.
In addition to these priorities, Manar continues to focus on issues pertaining to the state budget, job creation, support for small businesses, the opioid addiction crisis in Illinois and more.
He is chairman of one of the Senate's two budget committees and is a member of the second budget committee. In addition, he is on the education, agriculture, labor and executive appointments committees.
His work has been recognized with numerous awards including:
- Friend of Agriculture from the Illinois Farm Bureau,
- Champion of Democracy from Common Cause Illinois,
- Dawn Clark-Netsch "Straight Talk" award from the Illinois Campaign for Political Reform,
- McGinn/Clark award for outstanding legislator by the Illinois Counseling Association,
- Public Service Award from the Illinois Electric Cooperatives,
- President's Award from the Faith Coalition for the Common Good in Springfield,
- Vince Demuzio Legislator of the Year Award from the Illinois Association of Community Action Agencies,
- Rural Legislator of the Year from the Illinois Hospital Association, and
- the 2016 Wall of Honor at Bunker Hill High School.
In addition to coaching little league baseball for Bunker Hill youth, Manar is a member of numerous civic and charitable organizations. He and his wife, Trista, have three children: Abbie, Will and Ben. They are members of First Congregational Church in Bunker Hill.


text:
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text:
After months of speculation, and reading between the lines of her Instagram account, model Cara Delevingne—who has recently turned her hand to acting in the film adaptation of John Green's Paper Towns—has confirmed that she is in a relationship with musician St. Vincent (real name Annie Clark).
Talking very openly in her latest cover interview for Teen Vogue, Cara said:
"I think that being in love with my girlfriend is a big part of why I'm feeling so happy with who I am these days."
And admitting how secretive she's been about the relationship, which was thought to have started after the pair met in December last year, she added: "And for those words to come out of my mouth is actually a miracle."
Discussing her sexuality, Cara doesn't go on to label herself either lesbian or bisexual, but instead admits to having felt confused and even "frightened" about her sexuality growing up.
"Women are what completely inspire me, and they have also been my downfall," she goes on to say, but then—somewhat conversely—adds: "If I ever found a guy I could fall in love with, I'd want to marry him and have his children."
So that's about as clear as mud, but if it works for her then that's all that matters.
But it's not all talk of love and romance in the candid interview; Cara also continues her seeming crusade against the modeling industry. Having previously revealed modeling made her feel "empty and angry", she labels the industry "fake" and like a "dysfunctional family" in the hugely revealing interview.
Which gives some context to why she's carrying on down the acting path, playing the enigmatic Margo in the latest of John Green's film adaptations.
So it remains to be seen whether she'll continue the acting thing, and ultimately end up shunning the modeling industry, or whether she keeps her talented fingers in both pies. Either way, we're just glad she's all happy and in luuurve.
This article originally appeared on Cosmopolitan.co.uk. Minor edits have been made by the Cosmo.ph editors.