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Application Stories
NGS identifies therapeutic microRNA targets for skeletal disorders
mRNA and microRNA NGS Services combined with
In vivo
miRCURY LNA™ microRNA inhibitor studies
Dr. Hanna Taipaleenmäki
Dr. Hanna Taipaleenmäki
is a research scientist within the group of Prof. Dr. Dr. Eric Hesse, in the Molecular Skeletal Biology Laboratory at the University Medical Center Hamburg-Eppendorf in Germany.
What is the main focus of your research?
The lab's main research interest is bone biology. We are interested in several skeletal disorders – mainly osteoporosis and breast cancer bone metastases. Our goal is to better understand the pathological mechanisms contributing to these diseases and to develop novel therapeutic approaches.
What is the specific aim of the current project?
The main purpose of this study was to identify microRNAs that are regulated in response to bone anabolic treatments (therapies that promote bone formation). We thought that if we can then modulate the expression of these microRNAs, we may be able to recapitulate the bone anabolic effect of the treatment. Therefore these microRNAs may be potential new targets for novel bone anabolic therapies to treat skeletal disorders.
We used a well-established mouse model and applied two different bone anabolic treatments –one that is already approved for use in humans and a novel upcoming drug. We then harvested the bones without the bone marrow, extracted total RNA and sent it to Exiqon Services to perform microRNA and RNA sequencing from the exact same RNA samples.
"Exiqon Services performed microRNA and RNA sequencing from the exact same RNA samples."
We were able to identify microRNAs that are downregulated in response to the bone anabolic treatments, and we have promising results indicating that inhibiting these microRNAs using
In vivo
LNA™ microRNA inhibitors might indeed be bone anabolic.
What, if any, was your previous experience with Next Generation Sequencing (NGS)?
We have done NGS before, but in collaboration with another group who had experience with NGS. This was our first time doing NGS ourselves.
What was the reason for choosing to perform the profiling using NGS?
We have done microRNA Arrays before, but now we really wanted to have a genome-wide analysis which provides much more information. In the future we also plan to look more into novel microRNAs, mRNAs and maybe even long non-coding RNAs.
Why did you decide to sequence both microRNA and mRNA?
Sequencing both microRNA and mRNA enabled us to identify changes on the microRNA level, and also to investigate what is happening to gene expression at the mRNA level, to understand which pathways are activated or downregulated as a result of the bone anabolic treatments. We were able to combine the microRNA and mRNA sequencing results to identify potential mRNA targets of specific microRNAs, and pathways that are regulated by these microRNAs.
Were there any challenges during the NGS project and how did you overcome them?
Bone tissue itself was the main challenge. Over the years we have established good protocols for RNA isolation from bone in our laboratory but even so it was challenging to get a good amount of RNA of sufficient quality for sequencing both microRNA and mRNA.
The RNA quality was at the lower end of the acceptable range, and we trusted Exiqon's advice that it was good enough to proceed with sequencing. With the sequencing itself there were absolutely no problems - we were able to obtain sufficient reads from our samples, and the RNA quality did not appear to be a problem.
Did you identify any interesting candidates from your NGS data?
From the NGS experiments we identified some microRNA candidates whose expression levels are downregulated in response to both of the two bone anabolic treatments. Some of the microRNAs we identified by NGS have been reported before in bone, but many have not. This is most likely because there are very few microRNAs that have been identified as being expressed in bone
in vivo
– very few sequencing studies have been done so far on bone due to the technical challenges.
How did you investigate the potential therapeutic applications of the candidates you identified by NGS?
We thought that if we can then inhibit these candidate microRNAs, we may be able to recapitulate the bone anabolic effect of the treatment, and this might offer a potential approach to develop new therapies for skeletal disorders.
So, we got some LNA™ microRNA inhibitors from Exiqon and we have very promising results indicating that inhibition of those microRNAs might indeed be bone anabolic. We first characterized some microRNA candidates with
in vitro
functional studies, and now we are finishing the
in vivo
studies using the LNA™ microRNA inhibitors in mouse models. We found that inhibition of even a single microRNA has a bone anabolic effect. We have not done any synergistic studies yet.
It is particularly exciting that we have been able to deliver the
In vivo
LNA™ microRNA inhibitors into the bone. We also delivered
In vivo
FAM-labelled LNA™ microRNA inhibitors intravenously to see where they go, and we were really positively surprised to see high signals in bone – that's pretty novel.
"We have been combining the NGS results with functional studies using [
In vivo
] LNA™ microRNA inhibitors in mouse models."
What were important aspects for you when choosing an RNA service partner?
Reliability is absolutely important for this type of analysis, so that you know that things are done correctly. The people – it's important to get support when needed and good communication. Time and cost are also important. It doesn't have to be the cheapest but you have to get what you want for the money.
Why did you choose Exiqon as your service partner?
We were discussing with another company but we have had such a good experience with Exiqon with everything over the years that we decided to choose Exiqon. Another important factor was that Exiqon provides analysis of the sequencing data, which was very important for us.
"Exiqon provides analysis of the sequencing data, which was very important for us."
What would be your advice to colleagues about getting started with RNA NGS today?
The important things are to select the service provider carefully since it is a very delicate procedure. Also bear in mind that you get a LOT of data. If you don't have any experience in bioinformatics analysis, and you don't have a provider who can offer you support or data analysis, then you might be lost.
"Select your service provider carefully since [RNA-Seq] is a very delicate procedure."
In this respect it is good that Exiqon processes the data, and you get the raw data, but you also get a further analysis of the data. Also, because there is such a vast amount of data – think very carefully about the questions you want to ask and what you want to get out of the experiment, and perform the analysis based on these specific questions (or ask your provider to).
"With NGS you get a LOT of data…if you don't have experience in bioinformatics you might be lost."
How did you go about doing a combined analysis of the microRNA and mRNA sequencing data?
The data analysis provided by Exiqon was very good. Once we had identified the candidate microRNAs we then did a more manual analysis to identify mRNAs predicted to be regulated by those microRNAs (we used miRWalk or TargetScan), and look at the pathways. We also looked at the predicted and validated mRNA targets provided by Exiqon's miRSearch analysis, and there were some overlapping targets.
What are the next steps in the current project and how do you plan to perform them?
First of all we are going to characterize the
in vivo
potential therapeutic effect of the candidate microRNAs in detail. To identify the potential mechanism of action for these microRNAs, we will use the mRNA sequencing data. Then we will look in even more detail at both the microRNA and mRNA sequencing datasets to see if there are any regulated microRNA or mRNAs, which are completely novel for bone. It's a lot of data so I think there will be a lot of work for the future!
What are the future perspectives for this research?
There are challenges in developing microRNA inhibitor-based drugs (tissue specificity, targeted delivery, etc.) but I do think that microRNAs may have a place in the clinic in the future.
When and where will we hear /read more about your studies?
We hope to report our findings within the next year.
Additional information
Learn more about NGS Services
Read more application stories


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subset: commoncrawl


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Natural History Illustration: Watercolor Focus with Sharon Birzer
UW Botanic Gardens, Center for Urban Horticulture, Douglas Classroom
3501 NE 41st St
Seattle, WA 98105
Thursday, October 31, 2019, 6:30 PM to Thursday, January 02, 2020, 9:00 PM EDT
Category: Classes & Workshops
Natural History Illustration: Watercolor Focus
Thursday, October 3, 2019, 6:30 – 9pm
7 Thursday Evenings, October 3-17, November 7-December 5 (No class Oct. 24, 31 and Nov. 28), 2019, 6:30-9pm
Gain confidence in observing form while working with biological subjects to document and interpret what you see. Build observational and visual interpretation skills while exploring illustration using a variety of techniques, including graphite, pen and ink, and watercolor. Explore how these essential media are applied to make drawings into more refined illustrations. The focus of this fundamental course is drawing, from gestural sketching to precision rendering of illustrations for scientific purposes. This class can be taken as part of a series with the next season's offering, which will focus on colored pencil techniques rather than watercolor. All levels welcome.
Register Online or by phone (206-685-8033)
Location: UW Botanic Gardens, Center for Urban Horticulture, Douglas Classroom
link for more information:


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| 13.9°C Belfast
Viewers reacted with both delight and bafflement as ITV was shut down for an hour, with some joking the blackout was "the best thing" they had ever seen on the channel.
As part of a national sports day event called I Am Team GB, ITV encouraged viewers at home to get off their sofa and do some exercise instead of watching television.
Double Olympic champion gymnast Max Whitlock was on hand to pull the lever to switch off all ITV channels in a clip aired just before programming stopped.
Many Britons took up the challenge, tweeting their activities during the hour.
One sports fan revealed he was going for a run, writing on the social networking site: "Great and brave idea #ITV , one day I won't be able to #run but today isn't that day!"
Another revealed she had just been for a "45-minute spin class", adding "g ood for @itv, let's get moving in whatever way we can".
However, many joked ITV's static screen was top viewing, while some refused to go out and get moving.
"The best thing I've ever seen on ITV," one Twitter user wrote, and another added: "I'm more likely to get out and run when ITV shows programmes."
Another viewer said they would merely choose another channel, adding: "ITV shutting down for an hour to encourage me to exercise is going to be a big workout for my thumb on the remote."
After returning home from Rio with their biggest medals haul in 108 years, many members of Team GB used the event to join members of the public at sporting activities across the country.
Over the bank holiday weekend, hundreds of sports venues and clubs are opening their doors free of charge as part of a collaboration between the National Lottery and ITV.
Whitlock, who joined members of the public for some handball at the Copper Box Arena in London's Olympic Park, said: "I first started gymnastics in Hemel Hempstead at Sapphire School of Gymnastics.
"Knowing how friendly and life-changing clubs like this can be, I'd encourage everyone to get involved in I Am Team GB - the nation's biggest-ever sports day."
Soap enthusiasts were also able to head to the Coronation Street set in Manchester, where Olympic champion cyclist Elinor Barker was taking part in an event on the cobbles.
Other Olympians joining in include rowers Karen Bennett, Katie Greves and Helen Glover, cox Zoe de Toledo, swimmer Jazz Carlin, trampolinist Bryony Page and gymnast Amy Tinkler.


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my body is nice, sometimes;
she tells me when I'm hungry,
or thirsty, and reminds me
when to sleep.
my body is mean, sometimes;
she causes indescribable pain,
and blood where it should not be,
and sadness too.
my body is scary, sometimes;
she reminds me that I'm mortal,
and that I'm dying,
but she reminds me to cherish life.
my body is mine,
and we may have disagreements
just like family,
but we will always be together.


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by Floyd and Mary Beth Brown
Fear-mongering works – why not try again? This must be the thinking behind Obama's latest attempts to manipulate the new Congress. Austan Goolsbee, chairman of the U.S. Council of Economic Advisers, trotted out before the cameras this week to threaten the Republican Congress, saying that if they don't raise the limit on the USA's debt ceiling, the "impact on the economy would be catastrophic."
Goolsbee spun


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Pancake mix? Laundry detergent? High-fiber cereal?
I felt foolish asking. A little uncouth, even. I really did love the look of it, that box on the cover of this year's InSider ... but, umm ... what was it supposed to be?
As she's wont to do, the graphic designer explained it patiently.
"It's just a product," she said. "A big box of information. The idea is that it could be anything."
Ohhh, I get it. 'Cause you use this guide in whatever way works for you.
Actually, the same principle can be applied to the Pikes Peak region itself. Some people come because they see a mecca for outdoors-lovers, and that's all they need.
Some get sent here for work, maybe in the Army or Air Force, and they fall in love with how the Springs fuses military and urban life.
Others take a calculated approach, adding together a variety of factors — relatively low cost of living, easy access to cultural opportunities, an intelligent populace — before deciding it'd be a great place to raise a family.
At the Colorado Springs Independent, our charge is to make sense of all the happenings that constantly shift the look and feel of this place, and to deliver that information in a weekly newspaper. This InSider, our seventh annual manual to the region, is just an extension of that mission, one meant to hold up all year long. So where we've missed something in this publication, or left you somehow wanting, please let us know by commenting at csindy.com, or sending an e-mail to email@example.com.
Otherwise, remember, this guide is anything you want it to be.
And if that sounds a little new-agey, well, we've got some of that here, too ...
Click here for a full InSider table of contents!


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Ive been updating the Rally Corsa page https://131abarth.com/?page_id=9 with new pictures. Note: ITS NOT READY, It will take time to fully update the page so you better check it daily to see all updates.
Major updates on 131 Rally Corsa page
Category: Uncategorized /
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Dr. Joe TuzaraThe writer was clinical research-physician-general surgeon for Saudi Arabian, Philippine and American healthcare systems and is currently an American freelance writer as well as op-ed contributor.
Unlike most re-elected presidents, Barack Hussein Obama is deftly exploiting foreign affairs at the expense of Israel and his own country's national security to burnish his legacy.
And while it is not surprising anymore, this president's manic delusions of grandeur and 'shameless' power grabs are intentional and not merely coincidence.
Obama's cynicism, deception, pathological lying, betrayal and broken promises to "fundamentally transform the United States of America" are not surprising because his Third World philosophy, vision, dreams and plans are irreconcilably at odds with our Constitution.
For Obama to remake our country into what he wants it to be, he must subvert the Supreme Law of the Land and build an imperial presidency.
That could explain the repetitive trends of impressive White House directives emanating from a government in cahoots with a compliant Congress.
Since Obama assured Israel that "you are not alone" less than a year ago, escalating sectarian strife and intractable conflicts in the Middle East presented Jerusalem with an enormous challenge to protect and defend itself from Islamic extremists intent on attacking the Jewish state.
Speculation aside, the Arabic language Kuwaiti news outlet Al-Jarida has learned from a US diplomat that 'Obama is seeking to visit Tehran this year and was expecting for the invitation to devote his new administration's policy in the region based on the principle of non-military involvement and harmony'.
The source pointed out that the most significant detail remaining to be decided is 'whether there will be a meeting between Obama and Supreme Leader Ali Khamenei, or whether that meeting won't be held'.
According to unknown diplomat, "Obama wants to be the first US president to visit Iran since the Khomeini revolution in order to show that he is an advocate of peace and dialogue even with those who chant death to America."
Similar to how it reacted during secret US backchannel talks with Tehran, already a "violation of the special relationship with Israel"; the White House categorically denied the report.
Although the improved ties with Tehran seem to be in America's national security interests, Obama's desperation to reach a comprehensive nuclear accord in exchange for Iran's recognition as a nuclear threshold state effectively betrays Israel and US Arab allies.
Under prevailing circumstances, Obama will not lift a finger to destroy Iran's nuclear program. But, we should also bear in mind that despite Obama's capitulation to the Iranians, Israel's ability to strike Iran's illicit nuclear program remains undiminished.
Regardless of the reasons for betraying Israel, the imprudent Obama administration's naive foreign policy demonstrates an astounding diplomatic incompetence:
The two-state framework is going nowhere and in danger of collapse; and the interim deal, castigated by Israeli Prime Minister Benjamin Netanyahu as an "historic mistake" was a grand deception that has nothing to do with dismantling Iran's nuclear infrastructure.
For these reasons, wary and assertive critics are 'casting Obama as a sucker for an Iranian charm offensive.' With regards to the Israeli-Palestinian talks, Israeli Defense Minister, Moshe Ya'alon denounced Secretary of State John Kerry's project "obsessive and messianic."
Other Israeli officials are quite unforgiving and slammed Kerry for threats on boycott and implied incitement for Palestinians to pursue a "Third Intifada" should talks fail.
Quite frankly, something is terribly amiss with Israeli leaders apologizing for their truthful, frank and outspoken assessments of emerging frontline threats to Israel. It was a terrible mistake, unfair and unnecessary gesture of appeasement.
Netanyahu's next meeting with Obama in March should serve a stern warning to Washington that 'enough is enough' and that Israel's determination of "denying Tehran an atomic bomb capability" is sacrosanct.
First and foremost, "diplomacy is about taking excuses, not giving them".
Overwhelming pessimism abounds, but the resolution of the faltering US-sponsored peace process with the Palestinian Arabs should depend on the successful final outcome of nuclear diplomacy with Iran.
The US failure to address Syria's dangerous disintegration and threat of terrorism from Hezbollah will not prevent Iran from building atomic weapons.
And that leaves Israel with no option but to act on its own. It will come to pass soon. Israel has the undeniable advantage to deliver a swift military-cyber-strategic blow to Iran's controversial nuclear program. In reality, the 'genocidal Islamic fundamentalists ruling Iran are contemporary Nazis reinforced with messianic beliefs'. Annihilation of the Jewish people and global hegemony are the only reasons why Iran would not stop from seeking nuclear weapons.
Iran giving up its nuclear weapons ambition is untenable and the potential for a comprehensive nuclear deal unattainable for the following reasons:
The Iran Sanctions Act (ISA) which is an "extra-territorial sanction" recognizes the fact that Iran's illicit nuclear activities, combined with its unconventional and ballistic missile production and support for international terrorism represents a threat to the security of Israel, the US and its allies around the world.
For one, it may not be politically correct to argue that Iran will not be free from the grip of sanctions until the Islamic regime first improves its human rights record and cease its support for international terrorism.
Over time, ongoing talks on a comprehensive nuclear agreement between Iran and six world powers is impossible- without dismantling Iran's nuclear infrastructure .
Iran's ultimate goal is to become a nuclear-weapon state. In his presentation of "Worldwide Threat Assessment" to Congress in January 2014, Director of National Intelligence James Clapper testified that, "Iran's ultimate nuclear intentions remain"
Although Iran claimed its nuclear program a symbol of national pride, Tehran's deployment of an ancient "armada of two" warships closer to the US maritime borders was a desperate bravado and a necessary appeasement of hardliners in Iran. But then again, 'enemy warships on one's very doorstep are not exactly foreign policy, but more a matter of national security'.
The real threat continues to rest on their ability to disrupt maritime traffic in the Persian Gulf, especially the strategic Strait of Hormuz. If anything, Iran's entire armada consists of outdated warships with antiquated weapons systems and they cannot hope to compete in blue-water operations against the US Navy, so the Islamic regime's provocation against Israeli and American interests is a symbolic "act of foolishness" that may trigger false flag attacks.
Given the ongoing nuclear negotiations between Iran and the world powers -- the Iranian navy's operation takes place in a politically sensitive context. For the US, this rhetoric translates as continued assurances of the effectiveness of current sanctions.
Absent serious doubt about what to do, the Iranians have yet to answer the International Atomic Energy Agency's (IAEA) questions about the "possible military dimensions" of their nuclear program. In addition, they have now built nearly 20,000 centrifuges and accumulated approximately 5-6 bombs' worth of enriched uranium.
Unless Ayatollah Khamenei miraculously reverses his relentless xenophobia, Obama's legacy will be that of an American president who appeased the most barbaric Islamic fundamentalist regime in the world.
The writer was clinical research-physician-general surgeon for Saudi Arabian, Philippine and American healthcare systems and is currently an American freelance writer as well as op-ed contributor.


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shut down Arctic drilling last year.
Obama's decision makes sense for a number of reasons, chief among them is climate change. Given what we know about carbon budgets it makes no sense to expand fossil fuel extraction. To achieve the required level of GHG reductions we need to radically curtail our use of oil and gas. We already have far more fossil fuels than can be safely burned. In this context looking for new sources hydrocarbons makes no sense.
Any assessment of Atlantic Drilling must also be weighed against potential risks. Such operations must be examined in the context of BP's massive oil spill in the Gulf of Mexico in 2010. The sinking of the Deepwater Horizon and subsequent months long oil spill was an unmitigated disaster from which the area has yet to recover.
Exxon's criminal malfeasance and the subterfuge that permeates the entire industry has pushed the public's perception of the fossil fuel industry to an all time low.
In February Hilary Clinton formally came out against Atlantic drilling. This tack to the left was meant to help her keep pace with her Democrat opponent Benie Sanders, but it was also in response to growing interest in climate action and waning support for the fossil fuel industry.
There are also economic reasons why it makes no sense to drill in the Atlantic. The low price of oil cuts into the smaller margins of complicated and expensive offshore drilling. In the longer terms investing a commodity that is destined to be worthless amounts to a ponzi scheme or a pyramid scam. We know beyond a shadow of a doubt that the music is going to stop and a lot of investors are going to get left out in the cold.


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Ice-cream coneJune 2017
Smooth and healthy raspberry ice-cream made with fresh berries and One Whey®.
2 servings
1 scoop One whey® - Raspberry White Chocolate
2 dl frozen Raspberries
2-3 tbsp Water
Blend all ingredients in a food processor into ice cream. Freeze one houre before serving.
Nutritional information (1 serving / 1 Scoops)
Calories 107
Protein 13 g
Carbs 8 g
Fat 1,5 g
Nutritional information (per batch / 2 Scoops)
Calories 215
Protein 26 g
Carbs 17 g
Fat 3 g
Protein-packed cookies with One Whey Vanilla White Chocolate and banana. Perfect way to satisfy your cravings.
These Protella Blueberry Protein Crepes are a hit for any breakfast meal. They take just minutes to prepare and are filled with fresh blueberries and banana.
Crunchy, healthy, protein-packed waffles made with One Pancake and Organic Peanut Butter.
There's nothing quite like waking up to the scent of freshly baked bread.


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Manchester, UK -- (SBWIRE) -- 09/25/2012 -- The e-cigarette industry is exploding in the UK right now, quickly becoming one of the fastest growing products in the country. This amazing phenomenon has spawned user review websites that help the purchaser differentiate between the various e cigarette companies across the globe. One such site, E Cig Click, does more than just publish reviews, but introduces the consumer to the people behind the products. Jonny Williams, the man behind the review and informational site recently sat down for an interview with Jac Vapour cigarette company owner Andy Logan, giving a face to the company so many have chosen for their alternative smoking habits.
Now that Jac Vapour products are available here in the UK, Williams questioned Jac Vapour owner Logan about what makes Jac Vapour brand so different from the many others in the marketplace. Logan replied, "We buy each item individually from different suppliers and package it into a kit ourselves that you can't get anywhere else. Our packaging isn't as slick because of this, but, we believe, what's inside works better than anything else."
Apparently consumers agree as sales for this brand of cigarette have skyrocketed. Says Logan, "I must have spent about £500 on kits, to discover the best one available at that time was only £40. So I got together a few partners and we formed JAC Vapour with the aim of providing the best quality, simple ecig we could find at a decent price."
Big news in the world of e-cigarettes has been the purchase of e cig giant BluCigs by traditional cigarette manufacturer, Lorillard. When questioned about his view on this, Logan replied, "It will put Blu in a very strong position within the industry and will undoubtedly see their marketing and retail presence grow with the backing of such a large company. If they plan on developing better e cigarette products and adhering to the principles that set the e cigarette industry apart from Tobacco and big pharma companies, then it's a good thing, although with the tobacco industry's track record, I'll believe it when I see it."
The owner of Jac Vapour continued, expressing his opinions on future regulations he foresees for the UK. "I think there will almost certainly be a licence fee of some sort and I would hope it's not prohibitive to smaller companies that have proven they are more sensitive to the needs and best interests of the public. I think there will also be regulations and controls to guarantee purity and safety, but again I hope these are done in a sensible fashion and not in a way that would hold back the innovation and progress of the industry."
Jac Vapour e cigarette company doesn't appear to be very worried about their future, as Logan says, "Consumers are pretty savvy these days, and can spot most of the rubbish some people attempt to sell. We are committed to providing what we believe is the best product available and our support is second to none."
Ecigclick.co.uk is an e cigarette review website based in the UK and has helped a large number of clients from all over Europe in their e cig purchasing decision. E Cig Click owner, Jonny Williams, has been using e cigarettes for a number of years and has used this experience to create a resource for e cig users to share their own experiences.


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I manage the fairly popular Toasts.Forms.Plugin which displays toast like notifications on all platforms. This was originally created almost 2 years ago by EgorBo when the notification system on each platform was not very extensible or usable, hence you had to create your own if you wanted to display notifications while the app was in the foreground and have some respectable customization options. With iOS10, Android Lollipop and UWP there is now a decent notification system on each platform. Considering the new functionality, the Plugin has been rewritten to use each of native platforms notification systems.
Whats Changed
In version 3.0 a lot has changed including many breaking changes but its still easy to use.
#1 – Native Platform Notifications
While this has now limited the customization of the notification, it now brings the notifications inline with the platform look and feel and allows them to be placed in the notification center. To me this is much better than out of place notifications with its own style and now works more seamlessly with the platform and what the user is expecting. It also allows possibilities such as sound and badges.
- iOS now uses UNNotificationRequest
- Android now uses Snackbar or Notification.Builder if >= Lollipop (or optional force either)
- UWP/WinRT uses ToastNotification
#2 – More informative result
I have kept the flow of the API the same meaning you await for the response of the notification, but instead of just a Tapped response you receive a much better result as to what happened. You now receive a NotificationResult with an Action with one of these options.
[Flags] public enum NotificationAction { Timeout = 1, // Hides by itself Clicked = 2, // User clicked on notification Dismissed = 4, // User manually dismissed notification ApplicationHidden = 8, // Application went to background Failed = 16 // When failed to display the toast }
#3 – Options
You now pass through options instead of a large parameter list. This will enable future API enhancements to be made without breaking existing apps.
public interface INotificationOptions { string Title { get; } string Description { get; } bool IsClickable { get; } // Platform Specific Options IWindowsOptions WindowsOptions { get; } IAndroidOptions AndroidOptions { get; } IiOSOptions iOSOptions { get; } }
#4 – Override the Image
On UWP, Android (Notification.Builder only) and iOS you can override the logo image. On iOS it isn't possible to replace the logo image via code but can be done in your info.plist.
The images work much like other components in Xamarin Forms, where you can just reference the name of the image and in UWP it will search the project root.
var options = new NotificationOptions() { WindowsOptions = new WindowsOptions { LogoUri = "image.png" } }
You can also add a url such as https://example.com/myimage.png or do a platform specific url such as ms-appx://.
For Android you can set the SmallIconDrawable in the Init() method on the platform. The Image MUST be in the Drawables folder to work.
// This is called on the Android Platform ToastNotification.Init(this, new PlatformOptions() { SmallIconDrawable = Android.Resource.Drawable.IcDialogInfo } );
Alternatively if you can pass this int value down into your PCL you can use this in AndroidOptions on a per toast notification.
Using The Plugin
After you have installed the plugin on each platform and your portable library, you will need to register and initialize it. Just after the Xamarin.Forms.Init(); line add the following. I am just using the DependencyService as an example, you can use any DI Framework.
DependencyService.Register<ToastNotification>(); ToastNotification.Init(); // For Android pass through the activity ToastNotification.Init(this);
On iOS just after this, we need to request permissions to show notifications because as Apple correctly states, they are disruptive to the user and hence permission is just common courtesy.
// Request Permissions UNUserNotificationCenter.Current.RequestAuthorization(UNAuthorizationOptions.Alert | UNAuthorizationOptions.Badge | UNAuthorizationOptions.Sound, (granted, error) => { // Do something if needed });
Now we can call a notification anywhere in your app with the following.
var options = new NotificationOptions() { Title = "Title", Description = "Some Description", IsClickable = false // Set to true if you want the result Clicked to come back (if the user clicks it) }; var notification = DependencyService.Get<IToastNotificator>(); var result = await notification.Notify(options);
Future Roadmap
This is open source software being coded on in my spare time, hence I can never guarantee any enhancement schedules but here is the main focus for improvements.
- Customizable Action Buttons
- Callback Action on notification result (so you don't have to await)
- Further customizable content
- Receive user input in from the notification


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Disneyland Park
Critter Country
Valid Park Admission Required
Mobile Orders
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Is that your stomach growling? Don't grin and bear it. Forage for tasty fast food in one of the park's most tranquil settings.
Picnic on cookout burgers and sandwiches as well as delicious home-style desserts in the middle of the woods.
Cross a wooden bridge and stroll through a pine forest to a rustic retreat nestled in the shadow of Splash Mountain, where an eager beaver statue welcomes you and your cubs with an all-important question: "Hungry?" We sure hope so!
Paw through a menu of delicious quick-service fare with a nod to the American South: cheeseburgers, crispy chicken sandwiches or a refreshing BBQ chicken salad. Chicken nuggets, hamburgers, cheesy macaroni and healthy snacks will satisfy your little ones.
If you're truly ravenous, try our BBQ Double Cheeseburger, a third of a pound of Angus chuck topped with BBQ sauce, cheese, an onion ring and jalapeño-pickle relish. It's served with a side of French fries or house slaw for a real humdinger of a meal! Those who prefer a critter-friendly meal can try Messy Melvin's Vegan Specialty Burger made from a vegan patty and stewed vegetables, served with a side of fries or house slaw.
But some of our bear-y favorite items are our desserts, made with TLC the old-fashioned way. Sink your teeth into a House-Made Funnel Cake, Churro Funnel Cake or Seasonal Funnel Cake drenched in a delectable topping.
Relax by the Rivers of America and take time out to admire the peaceful waterfront view.
Surrounded by lush greenery, wave from the restaurant's 2-story sprawling terrace as the Mark Twain Riverboat, Sailing Ship Columbia and Davy Crockett's Explorer Canoes cruise by. Enjoy views of the Pirate's Lair on Tom Sawyer Island—it's a welcome escape while refueling for your next big adventure.
Located in the heart of Critter Country, your cubs will love the impromptu wildlife lesson! Look for ducks waddling along the river shore, squirrels scampering about and other adorable woodland creatures!
Short on time? Order a ready-to-go meal that comes with reserved viewing for Fantasmic!
Maximize your time in the parks by placing orders and paying ahead for food and drinks with the Disneyland app.
Prepare for a wild time—explore a forest filled with classic attractions, dining, shopping and more!


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1 answer
704 views
Are there boats/ yachts to hire on Black Sea off turkey ?
about 7 years ago about Turkey
Or should we go to aegon ?
Asked by Pad thai via Travellr.com
1 Answer
I dont think so but maybe you can hire a boat in istanbul to go to black sea about 7 years agoAnswered by Traveloturc via Ask a Nomad iPad app


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New Colorways are LIVE!!!
Our new colorways are all up on the website as I type this. There are 15 of them total. Some of them are BeSpeckled and some are Multicolors. I am feeling really inspired right now so I have quite a few more coming but my lovely production dyer team request that they do not have to learn 20 new recipes all at once so… . It is a lot!
I have to say I am experiencing a fair amount of love for some of these.I am so tickled with Heckley Speckley that I can barely contain myself. It's a little Antiquated System meets Sea Scum Run for a brew with a splash of Spicy Plum. I knew as soon as I sprinkled the dye powder on it that It was going to be one of my top 10 color loves. I will need you to keep this a secret between you and me so the other colorways don't get jealous. The last thing I need is a hues hurt feelings causing tension in the barn.
One of the other new colorways I made this past weekend in Blue Moon's very first Dye Camp Session. We made great colors together and had all kinds of fun. I was a little nervous since it has been awhile so was happy that the class was just the perfect size and group for getting my hands back in to the teaching dye cauldron. Intro-Speck (Thank you Linda for the great name!) I made by showing layering color and saturation techniques. I knew as soon as I was done that this had to be a colorway, they all agreed! So here they are.
Not too shabby eh? Do you see the Flamingo Feet there?? I found this picture of Flamingo feet (and legs too) and was smitten so of course it had to be a colorway. Check out my instagram feed to see them together. I even put little black dots for their black toenails. Some days my job is just way too much fun.
Oh…I almost forgot then there is Tourmaline SunAngel that is all kinds of wonderful but most especially so on Single Silk Targhee and Featherlight and Sparkle. Oh my on Sparkle it's to dye for!
Okay…I'll stop. I need to get this up so I can get out to the barn to help dye now that the sock yarn is showing up.
Orders Update: yeah so one of our shipments of lightweight that we were expecting to fill orders and dye for sock club did not show up. Yeah the mill lost the order or something they can't really explain. Yeah slightly stressful. Anyway it is showing up now and we are dyeing out little hearts out!! We are sorry for the delay! I am planning on working all weekend to play catch up. We appreciate your patience and understanding. Also why does this kind of thing always happen in the middle of a sale??
A little secret….because it has been crazy busy with this mill thing. I have not had a chance to change our yarn and roving specials. So they are still on special and will be at least for this weekend. Enjoy!
Shhh…. don't tell the boss.
Okay off to dye massive amounts of sock yarn!!!
Stay cool!!
Have a fabulous weekend.


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"We were at a loss as to what we might do with a long, narrow garden space running between our newly built garage and our heritage home. We had commissioned a very special cast bronze statue, "Alice" from Alice in Wonderland that we wanted featured in this backyard.
We felt comfortable immediately with Matthew, particularly as Matthew had innovative ideas and concepts plus he was not fazed by our odd barren site.We hired him on the spot. Matthew and his team were effortless to work with both on the design and construction side of things. The site was always tidy and safe, they were reliable and kept us informed. In fact, we were called away during construction and knew we were in secure hands for the work to continue.
We are absolutely thrilled with the result. Its actually more than met our expectations! Now, every day, we admire and delight in our new garden, Looking at it brings us great pleasure.
Thank You so much Matthew and your great team.
In fact, we are going to hire them again to redo our front yard to bring it up to our back yard standard!
I am more than happy to highly recommend Matthew O'Grady Landscape Designs. "
Di , Semaphore.
Winner, Awards of Excellence 2017, Master Landscape of SA.
"Matthew O'Grady Landscape Designs undertook a specialised paving job around our 100 year old stone building and an equally old Olive Tree. The job was very complicated , given the tree, and that the building does not have any straight walls and was not a "Normal" building in any regard.
We were very impressed with his care, professionalism and thought. The job was completed very successfully and in good time to a very very high standard.
Adding to that, was the creative and thoughtful way the paving was blended into existing older paths and paving areas using beautiful curves and creative shapes above and beyond our expectations and to a wonderful effect.
We are thrilled! We would use Matthew O'Grady Landscape Designs and his team again, in an instant.
Thank You Matthew. "
Gavin Trott, Kingswood.
"I had a tiny courtyard that badly needed revamping as it was very overgrown. I am no gardener, yet I wanted a pretty space to sit in, to dance in, to welcome guests in and be low maintance. I also did not want to go to the troble and expense of ripping out the pavers already there although they needed work.
Matthew came along with great ideas and such enthusiasim! I left it all to him after initial consultations.
I simply love my new courtyard! It has a wonderful hand made water feature with a dragon spout – I adore dragons and a matching dragon pot. Splashes of yellow, my favourite color which blends the inside to the outside so well. It's lit at night, smells delicious, has an irrigation system and a sitting are with enough space to still do a small dance. My guests so admire it, I'm overjoyed!
Thank You Matthew and his team.
Pleased to recommend your landscape services. "
Dee, Adelaide.
Nominated, Awards of Excellence 2017, Master Landscapes of SA.
"We engaged Matthew to carry out a complete renovation of our front and rear gardens. Matthew and his team worked consistently and quickly,completing the landscape within 6-8 weeks. Their work is of high quality and was carefully planned to a scaled plan, to suit our requirements and lifestyle.Matthew and his team are very knowledgeable and professional. Matthew provided excellent after-sales care, ensuring that the gardens are flourishing and attending promptly to a small number of minor issues that arose following the completion of the gardens. We are thrilled with our new gardens and would be glad to recommend Matthew O'Grady Landscape Designs to other prospective clients.
Jeanette and John, Torrensville,.
"Matthew O'Grady Landscape Designs has undertaken 2 landscape projects fir us – having completed the first , including paving our pergola, he was our first choice when we undertook the garden renewal at the front of the house. Matthew O';Grady Landscape Designs were recommended to us and we know why. Matthew is a consummate professional. He is timely and efficient, with a great eye for detail and willingness to debate design issue that always resulted in a better outcome than the one we first suggested. Matthew and his staff at Matthew O'Grady Landscape Designs are polite, pleasant and easy to deal with. We can't recommend them highly enough!
Vanessa and Chris, Rostrevor.
My husband and I are the owners of the garden, which won the Awards of Excellence 2016. Rightly so,we are more then happy about every detail Matthew O'Grady worked and achieved while planning and executed the work in now – our beloved garden. It's been almost 18 months since our garden was completed and the results are even more divine that we could've praised before. We love our garden and all people who ever visited and visiting us always glorifying and admiring our little green oasis, Matthew created for us. Above the excellency it's also a very low maintenance garden, which adds greatly to our amusement and daily joy. Thank You Matthew,"
Regards, Pola & Eddie, Somerton Park.
Winner, Awards of Excellence 2016, Master Landscapers of SA.
My wife and I engaged Matthew O'Grady Landscape Designs to undertake upgrading of two separate patio areas at our home. The upper patio required the removal of existing plants and post and replacement with fresh, new ones which harmonised with the general setting and each other.
The second patio located on the ground floor level involved the removal of a hedge which blocked a sea view, replacement of old pavers and a complete redesign of the space with feature plants and trees and a glass wall.
We are delighted with the finished product. We would be remiss if we did not also acknowledge the efforts of the other members of Matthew's team, Therese and Adam. Together, they achieve a result which we are delighted with. We would have no hesitation in recommending Matthew O'Grady Landscape Designs for any garden renovation or brand new garden.
Kind regards Barry and Heather Brown, Kingston Park. Nominated, Awards of Excellence 2017, Master Landscapes of SA.
A very big thank you Matthew for making such a great job of our driveways. Just how I had wanted them in the first place before we were talked into the crushed granite that had been put down by the previous 'so-called' Landscape Gardener, which I hated from the minute it went down. Finally our garden is starting to look like a garden instead of a builders yard. We will be in touch again as soon as we organize ourselves downstairs!!
Kind regards Patricia Pledger, Adelaide.
"It was very pleasing to engage Matthew O'Grady Landscape Designs . We asked them to pave a large area, Matthew recommended Madagscar limestone for both the back yard area and patio area. The team work was outstanding, the preparation of the site excellent and through. Matthew always asked for our input too and we were guided by his recommendations. They also did the garden bed water feature as well as designed the plants around it and added lighting. After a few months of plant growth, it now looks magnificent which William and I are very impressed with – we love to show it off to our many visiting friends. They also did the plants in pots under our patio area. We would recommend Matthew O' Grady to any-one. We are going to do our front yard soon, we are going to use Matthew again. "
Kind Regards, Neville and William Franks, Woodcroft.
Nominated, Awards of Excellence 2017, Master Landscapes of SA.
Whilst some landscapers I contacted found redesigning and rebuilding my old wooden steep steps in an awkward position at the rear of my steep hillside property difficult, not so for Matthew O'Grady and his team. Matthew suggested masonry blocks and included 2 landings for easier and safer access. This was also aesthetically pleasing. The work carried out was fantastic and to budget. I would highly recommend Matthew to anyone.
Eddie, Bridgewater.
Matthew O'Grady Landscape Designs has done a fantastic job for me. Well done.
Trish March , Happy Valley.
I have now used Matthew O'Grady and his team on two occasions. They are very efficient,reliable and come out the other end with a quality job. I would recommend Matthew O'Grady and his team as your first choice for keeping the client informed and his exemplary customer service."
Gary (Jack) Williams, Unley.
We got a very good job and a very good price. I happily recommend Matthew O'Grady and the whole business.
Wayne Brown, South Plympton.
Happy to recommend Matthew O'Grady Landscape Designs.
Thomas Short, Fulham Gardens.


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Many of you will have read about the debate in Tennessee about the legal definition of Tennessee whisky. The "bourbon + charcoal filtration" definition was adopted as state law last year. Now Diageo – present in Tennessee with George Dickel – has tried to have the law changed in a way that would also allow used barrels to be used for maturation. But this attempt was not successful, the law remains unchanged.
I don't want to go too deeply into the pros and cons of the used barrel issue here. Some have argued that it would ultimately compromise the overall quality of the whisky or even regard Diageo's step as an attempt to damage the status of Jack Daniel's as global competitor of Johnnie Walker. Others see this as no big deal at all.
It should be pointed out, though, that the current requirement for fresh barrels to be used for bourbon, rye and some other types of American whisky is a result ot successful lobbyism of the cooperage union after the end of prohibition. So it was essentialy forced upon the industry by external pressure, but it was soon embraced to such an extent that it is often regarded as essential for American whisky.
But in fact this is not the case. There have always been types of American whisky that could be made with used barrels: Corn whisky and "light whisky". In the 1970s and 1980s when the US whisky industry was hit by a severe crisis, many producers embraced used barrels as a means of cutting costs and also attracting new customers with a lighter whisky style. As an example here is a 1971 advertisment for Barton's QT that makes the use of used barrels a selling point. Another example is Early Times that switched to a mix of 80% fresh and 20% used barrels in 1983, thus deliberately dropping its "bourbon" status.
In America the maturation in used barrels has become eponymous with bottom shelf whisky because in most cases this is done to save on production costs. But used barrels don't make worse whisky, it just takes longer until it is good; and fully matured American whiskies from used barrels are hard to find, if at all. This is definietly one reason why Diageo's bid in Tennessee was seen as negative by many.
In Scotland things are entirely different. Scotch whisky has traditionally been matured in used casks, and especially bourbon casks take up the bulk of the space in Scotland's whisky warehouses. But as we know, the Scottish distillers have been facing not a crisis, but the opposite. Growing global demand has put pressure on aged stocks, so the producers are forced to be creative in order be able to bring younger whisky to the market.
One of several options to do this is the use of fresh "virgin oak" casks which impart strong wood flavours to the whisky much faster than used casks. And it is no wonder that many of the recently released NAS expressions are relying on the effect of fresh casks at least to some extent. These casks are of course more expensive than used ones, but the shorter maturation time can offset this, at least partly. And the novelty aspect allows for higher prices and ultimately higher profits.
So on one hand we have American distillers trying to be more successful with used casks, and on the other hand their Scottish colleagues try to do the same by using fresh casks. The whisky business can be quite twisted indeed. The key to understanding this apparent paradox is the difference in problems faced.


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BRADY PROHIBITION SIGN No Smoking Polypropylene H600mm x W450mm
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|Drive type:
|2dr Coupe GT
|Interior color:
|Vehicle Title:
|Item location:
|Local pick-up only
1994 Ford Mustang GTRight out of the gate...this is one heck of a driving machine. This 1994 Ford Mustang GT is ready for the road and also ready to show you what kind of muscle that it brings to the street. The engine, a Super Charged 302ci that will throw you back in the seat that is matched perfectly with a 6-speed manual transmission. When you watch the video, you can hear the super charger in action. The interior is... in AWESOME condition. The Ford Racing buckets with matching back seats look great. The Konig Wheels are also a great addition and a contrast to the Black car. The Autometer gauges on the left riser rail just add to the coolness of this ride. If you could see this car in person...please do. If you can't, send somebody to represent you. We will be glad to assist in any way.1994 MUSTANG GT PARTS & ACCESSORIES LISTING:? T56 six-speed transmission ? Vortec Sib S trim super charger? Anderson Power Pipe? Mac long tube headers still have cats installed? Mac rear stud griddle? 3.73 gears? Aluminum drive shaft? Pro 5.0 shifter? King Cobra clutch? Adjustable clutch quadrant? Edelbrock ported, polished, and powder coated heads? Denso spark plugs? Nitto 245x40ZR 18 tires? Koenig Image rims including spare tire? Gemico custom carbon fiber interior? FloFit custom seats? New carpet? 3-pod pillar and 2 clock pod gauges (boost, fuel, oil, air, water) auto meter? Florida 5.0 custom dash gauges (white faced auto meter)? Optima battery? Billet pedals? Weiand Hi Volume aluminum water pump? Steeda aluminum radiator? Quad shocks? Tiecko 5-way adjustable shocks? Caster camber plates? Chrome strut tower brace? Sub frame connectors? Bear brake tie rod ends? 90 MM lightning mass air? BBK 70 MM throttle body? 52 lb. Ford Motorsport injectors? 1.7 Ford Motorsport roller rockers? Custom Diablo Chip-Tuned by a Ford Cobra technician out of California? Ford Racing leather interior? Alpine CD player? Alarm system - custom? Cobra headlights with diamond cut clear side markers? Ram Air Harwood hood? Stalker body kit? MSD 6AL with boost retard CRUISIN CLASSICS is your one stop destination for all of your performance upgrades and service needs.CRUISIN CLASSICS PERFORMANCE CENTERis known for it's FIRST CLASS service in performance upgrades that will complete your checklist of must haves to make your machine just the way you want it.Here is a short list of our High Quality...High Performance servicesComplete classic/muscle car maintenancePower windows, heat/Vintage Air (Certified Dealer and Installer)Engine rebuildingCarburetor rebuildingTransmission upgrades and serviceRear differential service including gear installationBrake service including DISC BRAKE CONVERSIONSSuspension rebuilding and upgradesTotal modernization of classic/muscle cars including addingPower steering, power brakes, tilt columns, cruise controland MUCH, MUCH MOREIf you have any additional questions, please call one of our friendly sales staff at 614-347-3302 or Toll-Free 614-347-3302. We will be glad to help in any way including a walk-around for a more detailed description, any questions on financing, or perhaps an interest in our Sell Your Car Brokerage Program. In business since 1996, we have sold cars all over the world and we insist on giving the best personal service in the industry.Thank You from all of us at CRUISIN CLASSICSThe sale is subject to the following conditions and representationsThis vehicle is being sold as is, where is with no warranty in connection therewith. The seller shall not be responsible for the correct description, authenticity, genuineness, or defects herein, and make no warranty in connection therewith. No allowances or set aside will be made on account of any incorrectness, imperfection, defect or damage. Any descriptions or representations are for identification purposes only and are not to be construed as a warranty of any type. It is the responsibility of the buyer to have thoroughly inspected the vehicle, and to have satisfied himself or herself as to the condition and value based upon that judgment solely. Seller assumes no responsibility for any repairs regardless of any oral statements about the vehicle.


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This article is from the archive of our partner .
We've all heard the schoolchildren's chant that goes, basically, "First comes love, then comes marriage, then comes a baby in a baby carriage," or some iteration thereof. Of course, in this day and age, that's not always the chronology at all, and sometimes whole bits are missing, sometimes there are whole new ones. Maybe there is a baby and no marriage, maybe there's no baby, maybe—and this would be the saddest option—there's no love. Jill Filipovic has an excellent piece in the Guardian today in which she explores "The moral case for sex before marriage." This seems to have been a long time coming, but no time is like the present as we remain a nation of people conflicted about things Puritanical and things Titillating.
Filipovic writes that in America we "love to tout the value of waiting until marriage to have sex," and in that vein of thinking, there are the pro-abstinence programs frequently funded by state and federal money; there are also those who rail against discussions of anything but abstinence as a way of promoting sex in teens. But even as the abstinence talk would seem to be an obvious line for some evangelicals and staunch conservatives, "sex-positive liberals hesitate to say that having sex before marriage is an equally valid – if not better – choice for nearly everyone."
Filipovic decides to be one of the first to say it, and so she does: "Having sex before marriage is the best choice for nearly everyone," backed up with several arguments. Pretty much everyone does it (even back in the old days); sex is more happiness-producing than is money; sex is good for your health; she explains—and those things hold true regardless of marriage. Further, the problem with waiting, she says, is that those who wait are usually those who marry early and have traditional views on marriage and gender. Those are also the people who tend to have higher divorce rates and unhappier marriages, she argues, citing the benefits of marrying later and having more gender-egalitarian marriages, with shared housework duties and a corresponding uptick in sex. Filipovic admits that not all sex is good, that unintended pregnancy and abortion rates are a problem, as are STDs (which can, of course, happen regardless of marriage). But her key point, I think, is here:
Instead of fooling ourselves into thinking that waiting until marriage makes sex "good", we should focus on how ethical, responsible sexual practices – taking precautions to protect the physical and mental health of yourself and your partner; having sex that is fully consensual and focused on mutual pleasure – are part of being an ethical, responsible human being.
Sexual morality isn't about how long you wait. It's about how you treat yourself and the people you're with.
Hear, hear.
There's another discussion underlying all this, though. Views of premarital sex have clearly changed, and Filipovic is right, we see it in movies, we read about it in books, most of us do it, with varying degrees of regularity and commitment. We're grown-up consenting adults, after all, free to live our lives. And culturally it's gotten to the point that there's even a bit of a reverse shaming at work: Despite what the abstinence promoters would say, "virginity" past a certain age is regarded with more confusion and possibly even concern than the opposite. The 40-Year-Old Virgin is perhaps the most obvious cinematic example, where that sexual status is a joke, even, and definitely a bit weird.
So why has it taken so long to say what Filipovic does? It's not "couth"? We're afraid as women that we'll be branded with one of those Limbaugh-slung words, one of those scarlet letters, as something no longer desired as marriageable? At one point the attribute of "virgin" seemed one of the most important of all for a woman going into marriage. Vestiges of that likely remain, but other parts—the judgments or criticisms, particularly of sexually empowered women—may never have gone away.
Even with the progress evidenced in society with regard to gender equality and women's rights, we still have a ways to go. And the institution of marriage remains in some ways a last hold-out for those steps of progress (just look at gay marriage, which still is an option in fewer than 10 states). This doesn't mean marriage is outmoded, but a lot of the trappings certainly are. Many women who would never support abstinence in their long-term cohabiting, committed adult relationships are likely to wear a white dress while walking down the aisle, because it's tradition. And just as a grown-up couple might register as if they haven't been living together with the normal number of fully functional pots and pans prior to being wed (and requesting new ones as gifts), we act as though these old no longer relevant traditions and beliefs (to help set up a working household for a new couple who may not be able to afford it otherwise) still hold true and are a crucial part of the experience. If we'd all be upfront about what was what, you'd imagine that quite a lot of the tooth would be taken out of the real and imagined judgments. And maybe we'd do better at being happy, having successful relationships and marriages, loving each other.
Filipovic writes, "But our cultural view of premarital sex as morally tainted makes it harder for couples to engage in real talks about their sexual needs and desires before marrying, the same way they would talk about their religious values, how many kids they want or whether the wedding cake will be chocolate or vanilla."
Moral or not, it would be freeing to admit that if we're old enough and adult enough to get married, we're old and adult enough to admit to having had premarital sex. And that maybe that old form of "morality" is the least of our worries.
Image via Shutterstock/alphaspirit.
This article is from the archive of our partner The Wire.
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The sessions are both Practical and Inspiring so you can Make Your VISION Happen!
See how our clients have benefited from VITAL Vision Consultancy
Through our experience of helping many Practitioners with their website's, they have transformed their practices and in turn themselves. The website confirms for them their enthusiasm and passion for what they do which is always inspirational to witness for the Practitioners and for Us.
Read for Yourself how VITAL VISION Consultancy has helped to Inspire our Practitioners:
What Happens during the VISION Consultancy?
One 2 One Vision Consultancy provides You with a individualised session tailored exactly for You and Your needs.
You will leave inspired with an action plan to take forward and implement which realises Your Vision for Your Practice/Business.
- Together we analyse Your current Practice - what's working, what do You love to do?
- We look at How You want to Evolve and Grow Your practice
- We look at Your Uniqueness and How we can translate it and Your Values into Your Brand that not only Inspires you but also the Hearts and Minds of Your Prospective clients
- We define which clients you wish to attract and how your marketing can attract your target clients.
- You will learn how to market the "Sizzle of Your Practice and not the "sausage"
- We create a VISION for your practice that's inspiring and realistic
- We define the Goals needed to make Your Vision Happen that are Practical and prioritised.
- We explore the potential of the Internet in getting your message across and creating the kind of practice You want, that gives you the wealth, freedom and deep fulfillment that you are seeking!
- We Scope out Your website with You ensuring it has the right inspiring design, navigation and key messages that reflect Your Vision.
- We can Support You during the early stages to Make You achieve your goals and stay on track with Your VISION and help to refine it.
If this ignites a fire within you then this feedback means "Go for it"! Call VITAL on and we can discuss the best way to Create Your Vision and reflect it for Your Practice/Business on the web!
Need some help right now in defining Your Vision?
Download Our Free Guide Now on "How to Create Your VISION for You and Your Practice" *
* In order to download you will be taken to an easy to use, dedicated download system.
About Your Visionary Facilitator - Marek Duchnowski BSc (Hons) RSHom, VITAL Founder
Marek Duchnowski is recognised as Britain's leading expert on website design and website marketing for the Health and Complementary Healthcare Sector.
"I'm just going to write this down whilst its on my mind. Without exception your life is inspiring. Thank you for making your dreams reality. Your actions enrich the lives of those lucky enough to cross paths with you. Today has been a blessing. Thanks"!
Sam, Practitioner
He inspires and shows practitioners, entrepreneurs and business people how to attract more clients and grow your business through marketing, your website and personal awareness.
He is a Teacher, Philosopher and a Singer.
"I think Marek displays a perfect balance between technical expertise and insight and awareness of the CAM practitioner"!
Hilary Davies, Nutritionist
His background is in web design and website marketing, for the last 12 years. He created and ran Medifile Ltd - the largest supplier of websites to the NHS. He pioneered websites for the NHS and developed many information websites for NHS organisations. Then in 2001 he started studying homeopathy www.londonhomeopath.com This inspired his love of holistic therapies and quickly he saw the need for CAM/Health practitioners to be better represented on the web in a more professional manner. Hence VITAL web design was started to promote CAM practitioners on the web and to help them attract more clients to improve people's health.
"I look forward to welcoming you to VITAL and working together to evolve and grow a thriving practice/business through the web."
Call Me Now on and we can discuss the best way to Create Your Vision and reflect it through your website
"We guarantee that you will leave INSPIRED and ready for the year ahead - if not You shall get a full refund"!
To Your Success and I look forward to hearing from you soon
Marek Duchnowski