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Colin Trevorrow, the director of Jurassic World appeared on the Jurassic Cast Podcast recently and it is safe to say that his comments on the Jurassic Park focussed podcast caused a buzz on the internet. The reason the podcast interview has garnered so much attention on social media and entertainment news sites like this one is because of how candidly Trevorrow spoke about plans for the franchise going forward. Not only did he talk about Universal's plans for a Jurassic World trilogy but he even confirmed a few little details that fans had noticed and speculated upon. The episode is a must listen for fans of the franchise, it really is fascinating the episode, which clocks in at just under an hour is packed with information about the production of the first instalment in the new saga set in the universe of Jurassic Park, as well as what is to come next. Not only that, we also get an insight into what is next for Colin Trevorrow himself, as he is actually on board to direct Star Wars Episode IX.
During the conversation the director of Jurassic World gave us a peek into the thought process behind the newest movies set in the Jurassic Park universe: "Honestly, the trilogy is articulated in Jurassic Park, it's all in there. Jurassic World is all based on Ian Malcolm's quote, 'You stood on the shoulders of geniuses to accomplish something as fast as you could, and before you even knew what you had, you patented it, and packaged it, and slapped it on a plastic lunchbox, and now you wanna sell it' That to me is Jurassic World, that's why I had all the product placement, that's what it was. The second one, Jurassic World 2, and as we were driving we tried to find, what is the foundation? 'Dinosaurs and man, separated by 65 million years of evolution have been thrown back into the mix together. How can we know what to expect?' That's why it's exciting that the movie did well, that leaves us a lot of room to run, and it was part of this design, it had a beginning, middle and end when we wrote the first movie. Now that the movie did well, we get to play that out." Like the hosts of the podcast I was geeking out hearing him talk about what went into creating Jurassic World.
It is down to his commitments to the third Star Wars movie in the new trilogy that Trevorrow won't be directing the sequel to Jurassic World. But he will reportedly be involved, he won't be in the driver's seat but he will be around. This is great news as I thought he did a fantastic job of revitalising the Jurassic Park franchise with Jurassic World. It paid tribute to the original trilogy while adding a modern spin. Film fans seem to be very cynical about reboots and remakes nowadays because there are so many around. It feels like a classic franchise is getting a reboot or a sequel every five minutes. But if a production company or director wants to resurrect a classic film series they need only to look to what Colin Trevorrow has done with Jurassic World for inspiration.
Regarding the plot of the second movie in the Jurassic World trilogy Trevorrow had this to say: "Jurassic World was very much made with the fans in mind, and I'm not going to forget it, but now we've seen a lot of 'dinosaurs chasing people around on an island' movies. I think you guys and also the general audience is going to be down to explore where else we can go. We know Owen is going to be in it and Claire will be in it and neither will be in the same place that we left them in this movie. Even though Claire is the one who evolves the most over the trilogy, it's her story that mirrors this changing world, Owen has shit to deal with. The two of them opened Pandora's Box in Jurassic World and each of them are responsible for different elements of it in different ways, and I think the way that these characters are connected to the circumstances of what's happening it's different than the previous films. It's not 'Let's manufacture a way to get them somewhere,' they're embedded into it now in a way that as story tellers makes it much easier for us to keep them involved and doesn't feel as contrived."


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K8IROS 8.1- Iron Man
It may come as no surprise that Spencer saved this K8IROS 8.1 x Kickasso edition for his birthday today as it highlights his favorite superhero -Tony Stark/Iron Man!!
This shoe was game worn by Spencer Dinwiddie on April 6, 2019, when the Brooklyn Nets played the Milwaukee Bucks at the Fiserv Forum in Milwaukee, WI.
***All proceeds from the auction go to charity in support of youth programs throughout the country.***
Winning Bid: $560.00
Item condition: New

subset: commoncrawl


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Woo, it is Friday! Weekend is coming soon.
Have you got any plan for the weekend? Travelling?Picnic?Play games with friends?Or even organize a team for adventure the desert, forest?
Anyway, whatever you plan to do and amuse yourself , safety always comes first.
If you prefer to adventure the forest or playing the airsoft, hunting or CS games, these mesh goggle glasses are the necessity you need and it does an wonderful protector for your eyes.
These light-weighted mesh goggle glasses will protect your eyes from striking by insects and hurting by tree branch in forest or other remote outer field. In CS games, they can resist the BB ammo while playing. When you play airsoft, these mesh goggle glasses will surely allow you to wear a balaclava or shemagh without worry of the fogging version. Besides, the soft plastic flame and ergonomic design make the mesh goggle glasses comfortable to wear. The metal mesh ensures the durable use of the glasses as they can withstand resist high impact. The elastic head-strap with buckles makes them suitable for different facial shapes and sizes.
Not want to own one pair and enjoy the comfort and protection?


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Tony Rice And His Famous 1935 Martin D-28 Guitar
Tony Rice, Clarence White, And That Famous D-28 Guitar
In the world at large, there is a serious lack of musical integrity. There are manufactured "stars" who can't play any sort of instrument, only sing songs written by corporate music execs for them to sing; and only do that while looking lascivious for the camera. Oh I could name dozens of the sorts of pop stars I'm thinking of, and you could too. Luckily for humanity's future, only the era of throw away stars and throw away pop will be remembered, as most corporate consumer music is single use and discard except in the instances of trivia.
If one ventures any distance from corporate radio and intentional dimwit drivel which never ceases emanating from a television set, then one might by chance encounter serious music, the kind of music one makes because they desperately love music, and seemingly must make music as their core inner being demands it of them. Guitarist David Anthony (Tony) Rice is that sort of musician. Tony Rice can't be said to be a household name; and it is probably true that the average metal or rock guitarist isn't familiar with Tony's music at all; but Tony Rice is to flatpicking guitarists something like what Tiger Woods is to modern golfers.
Tony was born the 8th day of June in the year 1951, in Danville, Virginia; but he spent his childhood in Los Angeles, California. Tony's father had been a semi-professional Bluegrass musician, and had spent considerable time teaching his interested sons about music, and musicianship. While in California the Rice family was able to run in the same circles as other prominent acoustic musicians. Tony would meet and befriend Clarence White, a brilliant guitarist of both bluegrass and rock and roll music, who'd die tragically young.
That Clarence White had a big influence on Tony Rice and his music goes without question. It's not mere chance that Tony owns Clarence's old 1935 Martin D-28 guitar; and it's no surprise that several of the best guitar manufacturers in the USA make their own very expensive reproductions of the specific and heavily modified D-28 guitar in question. The reproductions of the guitar are sometimes known as Tony Rice models, and sometimes known as Clarence White models. Tony's famous guitar might be the single most desired acoustic instrument in the world that isn't a Stradivarius violin.
Some might call it heresy. Some might suffer for having their notions squashed. Others will rejoice. The facts of the matter are that in more recent years, Tony Rice has come to prefer one specific guitar made for him over the legendary Martin instrument[1]. Of course it is one of the several Tony Rice Professional models designed for him by the Santa Cruz Guitar Company, and designed to be as similar to the Martin instrument (the 1935 D-28 which used to belong to Clarence White is heavily modified) as possible. It was bound to happen, of course, after many years of back and forth with the luthiers at the SCGC, they were bound to eventually come up with an instrument Tony would prefer to one he'd played seemingly without ceasing over the years.
David Grisman, Tony Rice, and Jerry Garcia
The Music Of Tony Rice
Bluegrass music was originally just traditional Scot or Irish fiddle tune style music, and incorporating a five string banjo, and some high tenor vocals along with rhythm guitar, mandolin, fiddle, and a big stand up acoustic bass. The guitar wasn't much thought of as anything but a rhythm instrument in the context of trans-Atlantic fiddle music in Appalachia. Over time what was known as "G runs," and other bits of licks were incorporated into the music provided by the guitarist, and nowadays if you hear one, it sounds very cliché.
Don't get me wrong here, playing great rhythm guitar, and keeping in time with some banjo or fiddle, or mandolin guy with an adrenalin rush at super fast tempos isn't easy; but originally that was all the guitars were used for in folk, Celtic, bluegrass, and country music. Doc Watson, the legendary blind guitarist from North Carolina was the person most responsible for taking the big dreadnought guitar, and deciding to use the thing for something other than just playing rhythm, or fingerpicking some country blues. While Tony Rice being compared to Clarence White is natural; it's also well to note here that Tony Rice, like Doc Watson, is a guy who had a triple attack, he could sing, and he could play with the best of the best in the fields of lead, or soloing, and rhythm too. Had? Well, probably anyone who's made it this far in this piece already knows; Tony Rice can no longer sing due to some injury to his vocal cords.
In 1974 Tony Rice joined J.D. Crow & The New South, as guitarist and lead vocalist, and the band recorded the album with the band's name as its title. While J.D. Crow's band always featured some of the best and brightest musicians in the Bluegrass genre, this particular lineup was special for also featuring Ricky Skaggs on mandolin. The album, produced by Rounder Records, would become the best selling item they'd ever had. Tony Rice brought not just his terrific guitar skills, but his unique and beautiful vocals to the mix. While the album could mostly be considered "traditional," it was also truly "progressive" in that Tony didn't pursue the "high lonesome" vocal stylings of people such as Bill Monroe, Ralph Stanley, or Jimmy Martin.
Bluegrass music is absolutely unique to the United States of America. It's a form of music based on fiddle tunes from the British Isles, but the instrumentation, and now most of the music itself; are uniquely American. Of course Bluegrass music is appreciated and played all over the world; and though Tony Rice has dedicated a large portion of his adulthood and career to traditional Bluegrass music, he's also spent as much or more time expanding it, and breaking from it altogether.
A Candid Discussion and Demonstration With Tony Rice
Playing Style
Of course Tony Rice can play very very fast. That's hardly what makes him such a special guitarist. Playing Bluegrass instrumentals with mandolin, fiddle, or banjo players is forever going to be a very strenuous thing for the flatpicking guitarist; as the guitar has a wider neck, and six strings to move across in hopes of maintaining the tempo. I should lay out right here for anyone who might have not realized it, playing fast on a steel string acoustic guitar strung with medium gauge strings is far far harder than it is playing at the same speed on a Stratocaster or something.
Tony Rice's guitar playing, insofar as one can tell, is flawless. You simply never hear him make a mistake, and every single note is loud, clear, and has such a beautiful, bell like tone-that it is hard to imagine how someone could ever execute such things so cleanly. What he does, and the reason he's so often thought of as the logical continuation of Clarence White; is he plays really wild, unexpected things, and he manipulates time in the context of any tune with complex syncopation.
Tony went from the J.D. Crow band to doing solo work with the very best side-men in the genre; and he expanded what was thought of as Bluegrass, or folk music by often covering tunes by artists outside of Bluegrass. Persons such as Gordon Lightfoot, Bob Dylan, and James Taylor come to mind. Collaborations with Norman Blake were treasured by guitarists. Tony has recorded solo albums, many albums with The Bluegrass Album Band, albums with The Tony Rice Unit, and of course, the albums with the David Grisman Quintet.
When I was younger, and even now whenever I'd get into playing my guitars regularly, I would think of this guy as the absolute "god" of playing an acoustic guitar with a pick. Oh Tony Rice isn't truly famous. I'd say most people who dabble with guitar don't even know who he is. It's no fault, but a credit to Tony he's forever taken his talents and used them purely to do what he's wanted to do, and not into the so typical notion that "making the most money possible is the best possible thing."
When Tony Rice met David Grisman in the 1970's, a new and American form of music became more attractive, and better. Some call it "Dawg" music, as Dawg is Grisman's nickname, others called it "spacegrass." What it is, is jazz played on bluegrass instrumentation. This form of music isn't commercial, and it isn't something one expects to become "popular." It is intellectual music somewhat reminiscent of the music of Django Reinhardt, and The Hot Club of France. Grisman and Rice mirrored Reinhardt and Grappelli in a way.
In his years of being a dedicated musician, Tony Rice has developed a rare thing, he's instantly recognizable when you hear him, and totally unique. I'll be very interested to hear what he plays in the future; as he does nothing unless it is done to the highest standards. Thanks for reading.


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Metal mega bands Metallica, Slayer, Anthrax, and Megadeth all have one thing in common: the heavy influence they received from Canadian heavy-metal band Anvil. Anvil flies under the radar, but if metal and hard rock is your kind of music, this is a show you'll want to check out. The band's musicianship is topnotch, with guitarist Steve "Lips" Kudlow pulling off solos that would give experienced players fits, and drummer Robb Reiner (not the actor-director) playing fills that would make Lars Ulrich blush. On top of that, the band is just outrageous. I mean, its last single was called "Badass Rock N Roll." How can you not think that's awesome?
Anvil plays with Bianca Diablo, Taste of Evil, Saints & Winos, and Beneath Hells Sky on Saturday, March 29, 8 p.m. at Montage Music Hall, 50 Chestnut St. $13-$15. themontagemusichall.com.


text: Hey everyone heres the scenerio, I have a laptop that was made in about 2003 and had xp loaded. DVD drive is now dead and need to reinstall windows xp. So I got a usb cdrom drive. BIOS supports usb data drive but will not boot this dvd drive on startup, but will a USB floppy drive. So my idea is to make a bootable floppy drive that can enable my dvd drive to work in dos and install windows. I have spent the last 5 hours going over all different boot disks that claim to work with no sucess. I tried duse, ect. I finally got a windows 98 boot disk and USBASPI.sys to recognize the drive, but then I get an error (command.com is currupt or missing). Any help please? here is my config.sys setting and autoexec.bat settings [config.sys] device=himem.sys /testmemff device=usbaspi.sys device=usbcd.sys /D:mscd001 [autoexec.bat] LH %ramd%:\MSCDEX.EXE /D:mscd001 /L:%CDROM% Drive is a LITEON USB EZDUB (recognized as a LITEON IHAS120). I have been through bootdisk.com's steps also with no luck.


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Sulforaphane treatment of autism spectrum disorder (ASD)
Contributed by Paul Talalay, September 4, 2014 (sent for review August 12, 2014; reviewed by Bryan H. King, Robert K. Naviaux, and Cecilia Giulivi)
This article has a Letter. Please see:
- Uncommon use of common measures in sulforaphane trial - January 13, 2015
Autism spectrum disorder (ASD), encompassing impaired communication and social interaction, and repetitive stereotypic behavior and language, affects 1–2% of predominantly male individuals and is an enormous medical and economic problem for which there is no documented, mechanism-based treatment. In a placebo-controlled, randomized, double-blind clinical trial, daily oral administration for 18 wk of the phytochemical sulforaphane (derived from broccoli sprouts) to 29 young men with ASD substantially (and reversibly) improved behavior compared with 15 placebo recipients. Behavior was quantified by both parents/caregivers and physicians by three widely accepted measures. Sulforaphane, which showed negligible toxicity, was selected because it upregulates genes that protect aerobic cells against oxidative stress, inflammation, and DNA-damage, all of which are prominent and possibly mechanistic characteristics of ASD.
Autism spectrum disorder (ASD), characterized by both impaired communication and social interaction, and by stereotypic behavior, affects about 1 in 68, predominantly males. The medico-economic burdens of ASD are enormous, and no recognized treatment targets the core features of ASD. In a placebo-controlled, double-blind, randomized trial, young men (aged 13–27) with moderate to severe ASD received the phytochemical sulforaphane (n = 29)—derived from broccoli sprout extracts—or indistinguishable placebo (n = 15). The effects on behavior of daily oral doses of sulforaphane (50–150 µmol) for 18 wk, followed by 4 wk without treatment, were quantified by three widely accepted behavioral measures completed by parents/caregivers and physicians: the Aberrant Behavior Checklist (ABC), Social Responsiveness Scale (SRS), and Clinical Global Impression Improvement Scale (CGI-I). Initial scores for ABC and SRS were closely matched for participants assigned to placebo and sulforaphane. After 18 wk, participants receiving placebo experienced minimal change (<3.3%), whereas those receiving sulforaphane showed substantial declines (improvement of behavior): 34% for ABC (P < 0.001, comparing treatments) and 17% for SRS scores (P = 0.017). On CGI-I, a significantly greater number of participants receiving sulforaphane had improvement in social interaction, abnormal behavior, and verbal communication (P = 0.015–0.007). Upon discontinuation of sulforaphane, total scores on all scales rose toward pretreatment levels. Dietary sulforaphane, of recognized low toxicity, was selected for its capacity to reverse abnormalities that have been associated with ASD, including oxidative stress and lower antioxidant capacity, depressed glutathione synthesis, reduced mitochondrial function and oxidative phosphorylation, increased lipid peroxidation, and neuroinflammmation.
Autism spectrum disorder (ASD) includes neurodevelopmental abnormalities characterized by impaired ability to communicate and interact socially and by restricted and repetitive patterns of behavior, interests, and activities (1). The prevalence of ASD in the United States is about 1 in 68 among children aged 8 y, with marked male (4.5:1) preponderance (2). No validated pharmacological treatments for the core symptoms of ASD are available. We report here that in a placebo-controlled, double-blind, randomized clinical trial, daily treatment with sulforaphane for 4–18 wk resulted in significant improvements in aberrant behavior and social impairment in a majority of young males diagnosed with moderate to severe autism, and that this improvement regressed upon cessation of treatment. Physician and parent/caregiver impressions of clinical improvement were evaluated by behavioral outcome measures.
Sulforaphane is an isothiocyanate derived from broccoli. Its therapeutic potential is based on its potent activity in transcriptionally up-regulating genes that control mechanisms whereby aerobic cells protect themselves against oxidative stress, inflammation, DNA-damaging electrophiles, and radiation (3, 4). Under basal conditions, these protective systems do not operate at maximal capacity but can be induced to higher activity levels by sulforaphane, thus reducing the risks of developing malignancies and other chronic diseases (5⇓⇓⇓⇓–10). Sulforaphane is now in widespread clinical evaluation (10).
The decision to test sulforaphane to treat ASD was based on four premises. First, extensive evidence shows that sulforaphane counteracts many of the same biochemical and molecular abnormalities associated with ASD, including oxidative stress and reduced antioxidant capacity, defects in glutathione synthesis, mitochondrial dysfunction and low oxidative phosphorylation, increased lipid peroxidation, and neuroinflammation (11⇓⇓⇓⇓–16). Although it is unclear whether these anomalies are etiological or secondary manifestations, their correction often improves ASD behavior (17).
Second, a variety of small molecules including sulforaphane can ameliorate a number of unrelated genetic disorders by activating the "stress proteome," which regulates many of the aforementioned damaging processes. Sulforaphane, as well as hydroxyurea, phenylbutyrate, and trichostatin A, have been shown in vitro to have therapeutic potential to reestablish cellular homeostasis in a number of unrelated genetic disorders (18).
Third, sulforaphane is a dietary phytochemical, derived from its precursor glucosinolate glucoraphanin, that is widely consumed in cruciferous plant-rich diets, and qualifies for consideration as a food, a dietary supplement, or a drug, depending on its intended use. Sulforaphane is therefore justifiably considered to be of low toxicity, and its administration to humans is well tolerated (10, 19, 20).
Fourth, widespread anecdotal reports have suggested that fever can dramatically but temporarily ameliorate the disturbed behavior of many autistic patients (21). Notably, the degree of improvement (mostly in stereotypic behavior and inappropriate speech) was unrelated to the severity of fever or of autism (21). This study explicitly suggested that elucidation of the fever response might provide insight into the mechanisms of ASD and point to new therapeutic approaches (21, 22). Fever up-regulates heat-shock proteins and related mechanisms central to multiple cellular processes in the CNS, including synaptic transmission (23, 24), and may improve long-range cerebral cortical connectivity that is depressed in ASD (25). Sulforaphane also up-regulates expression of the heat-shock response (26).
We hypothesized that daily treatment with sulforaphane at levels achieved by diet might reduce the severity of socially impaired behavior in ASD. Behavior was quantified directly by three widely validated behavioral outcome measures at the periods before, during, and after intervention (Fig. 1). Parents/caregivers completed the Aberrant Behavior Checklist (ABC) (27) and the Social Responsiveness Scale (SRS) (28). Study physicians completed the Clinical Global Impression Severity (CGI-S) and the Clinical Global Impression Improvement (CGI-I) scales (29, 30).
Participant Characteristics.
More than 90% of all scheduled tests were completed on the 40 participants who received placebo or sulforaphane treatment and returned for the first return visit (week 4). Twenty-two participants (6 placebo, 16 sulforaphane) were also tested at 22 wk, 4 wk, after treatment ended (Table 1 and Fig. S1). Four participants (one placebo, three sulforaphane) were lost to follow-up before their first on-treatment visit.
Participants, all male, were 13–27 y old at enrollment (median: 17 y). A history of behavioral improvements with fever was given by a large majority (32 of 40; 80%) of participants. Participants in sulforaphane and placebo groups were well matched, and did not differ at baseline with respect to various demographic, behavioral and clinical features, behavioral outcome score measures, abnormalities in physical examination, blood chemistries, hematology, and urinalysis (Table S1).
Analysis of Outcome Measures.
The total and the changes in total ABC and SRS behavioral scores of the 26 sulforaphane-treated and 14 placebo recipients from enrollment to the 18-wk end of treatment and after a 4-wk recovery period are shown in Figs. 2–4 and Tables 1 and 2. Treatment group mean ABC scores differed significantly at 4, 10, and 18 wk (Fig. 2 B and E for ABC and SRS, respectively). At 18 wk there was a 34% reduction in ABC and a 17% reduction in SRS scores, and these trended toward nonsignificant differences upon cessation of treatment (Fig. 2 B and E and Tables 1 and 2).
Significantly greater improvement was observed among participants randomized to sulforaphane at 4, 10, and 18 wk for irritability, lethargy, stereotypy, and hyperactivity subscales of the ABC, and in awareness, communication, motivation, and mannerism subscales of SRS (Fig. 3 and Tables 1 and 2). After stopping sulforaphane treatment, both ABC and SRS subscores tended to revert toward baseline.
On subscale analysis of CGI-I scale scores at 18 wk (Tables 1 and 2), 46% (12 of 26), 54% (14 of 26), and 42% (11 of 26) of sulforaphane recipients were much or very-much improved on social interaction, aberrant behavior, and verbal communication, respectively, compared with 0% (0 of 11; P = 0.007), 9% (1 of 11; P = 0.014), and 0% (0 of 11; P = 0.015), respectively, for placebo recipients.
Individual changes in total ABC and SRS scores from basal levels to 18 wk are shown in Fig. 4. A positive response was defined post hoc as a 30% decrease from baseline in total ABC and SRS scores. Thirty-five percent (9 of 26) of participants on sulforaphane had a positive response on SRS compared with 0% (0 of 11) on placebo (Fisher's exact test P = 0.036), and 60% (15 of 25) of participants receiving sulforaphane had a positive response on ABC compared with 20% (2 of 10) on placebo (P = 0.059).
Our clinical impressions during the study, although blind to group assignment, were that 13 of the 40 participants improved noticeably with respect to sociability and behavior, usually observable by 4 wk; all were receiving sulforaphane. In queries to families and caregivers, before unblinding, 17 of 26 whose sons had taken sulforaphane reported gradual changes within the first month of treatment and correctly surmised their group assignment, whereas the remaining 9 on sulforaphane—and all but 1 of 14 who received placebo—were not improved, and believed that their sons had not received sulforaphane. Positive responses to sulforaphane were spontaneously reported by parents and caretakers, who commented (before disclosure of treatment category) on improved social responsiveness, behavioral compliance, and calmness in the subjects with ASD who were taking the active compound.
Safety and Adverse Events.
Sulforaphane treatment effectively improved core aberrant behaviors of ASD, and was safe and well-tolerated (Table S2). Notably, none of the laboratory results were outside normal ranges at any time point (Dataset S1). Unexpectedly, the sulforaphane group gained significantly more weight over the 18-wk period, compared with placebo (4.31 vs. 0.31 lb, P = 0.056). Pulse rate was lower in the sulforaphane group both at baseline and during the study. Thirty-six adverse events were noted during the trial. Vomiting, increased aggressions, abdominal pain, increased flatulence, irritability, constipation, diarrhea, fever, headache, and exacerbation of seasonal allergies were reported in 12–19% of participants on sulforaphane; their incidence was the same in the placebo groups (P > 0.10).
Two participants had single unprovoked seizures: one after 3 wk on sulforaphane, with an undisclosed history of recent seizures; the other 3 wk after discontinuing treatment and a past (more than 1 y) history of seizures well-controlled with antiepileptic drugs. Although patients with autism are predisposed to seizures (31, 32), we cannot rule out the possibility of seizures as an adverse effect of sulforaphane in ASD.
The behavioral outcome measures (ABC, SRS, CGI-I) and clinical observations by study physicians and many parents/caregivers, all before unmasking, indicated that many of the participants who were treated with sulforaphane in this study had statistically significant and clinically meaningful improvements during treatment with sulforaphane. The substantial improvements of individual ASD patients' trajectories were conspicuous and suggest that further investigation of sulforaphane in ASD is promising.
Although we observed consistent and large improvements in behavior in the majority of sulforaphane-treated ASD, this was a single-site, limited dose-range study of only 44 male, predominantly Caucasians, aged 13–27 y, 4 of whom dropped out of the study before their first follow-up visit. Although we did not test specifically for adaptive or cognitive skills at baseline, our cohort included subjects with moderate and severe ASD with substantial variability in total baseline SRS and ABC scores (Fig. 4 and Tables 1 and 2). Because of considerable heterogeneity in the etiology, pathogenesis, and symptomatology of ASD, generalization of our findings requires confirmation.
Nevertheless, this study may shed light on the basic pathophysiology of at least a subset of ASD. Most clinical studies and medications aim to restrain ASD's troublesome symptoms. In contrast, this study was, to our knowledge, one of the few designed to target core clinical features as well as the fundamental biochemical abnormalities of ASD (oxidative stress and antioxidant deficiency, increased susceptibility to electrophile toxicity, and inflammation) by the administration of sulforaphane.
Our suggestion that participants with ASD whose behavior improved during fever would also respond to sulforaphane could not be confirmed because of the unusually high prevalence of fever responders (80%) in our cohort compared with most ASD populations (35%) (33). Unlike the rapid onset of changes in behavior during fever in ASD, responses to sulforaphane in this study appeared over several weeks. This finding suggests that sulforaphane may cause increases in gene transcription in multiple underperforming cell-signaling pathways (34, 35). Sulforaphane may be only one of several small molecules that will ameliorate deficiencies that lead to abnormal functioning in the whole organism. Further studies of sulforaphane's effects at the cellular level, if confirmed, could guide discovery of new drugs with similar underlying mechanisms of action in ASD.
Activation of the cellular stress response, in addition to its therapeutic potential, is known to protect cells from environmental toxins. Recently, we demonstrated the efficacy of sulforaphane as an environmental detoxicant (36). Together with sulforaphane's capacity to activate the Keap1–Nrf2 cytoprotective signaling pathway (10), it may therefore protect against both environmental and endogenous risk factors that affect brain development in ASD (37). Given its favorable safety profile, future studies should address sulforaphane's potential benefits for the prenatal prevention of ASD as well as for the early treatment of young children with this disorder.
Materials and Methods
Study Protocol.
This study was conducted at the Lurie Center for Autism of the Massachusetts General Hospital (MGH) for Children with approval of the MGH and Johns Hopkins University Institutional Review Boards, and was registered at ClinicalTrials.gov (NCT 01474993 under Food and Drug Administration IND 113542). All participants who were able, and parents or caregivers, gave written informed consent. All participants met criteria for autistic disorder (1). Forty-four male ASD patients were enrolled from February 2011 to July 2013. The Autism Diagnostic Observation Schedule, performed by a trained psychologist/tester (in 43) or DSM-4 (1) checklist of symptoms performed by a trained physician (two participants), were used to confirm the diagnosis of autism at the screening visit. All participants were moderately to severely autistic on the CGI-S, with varied cognitive capacity (Table S1).
Eligibility criteria included male sex, age 13–30, no intercurrent chronic illness, no history of active seizures within 1 y, and normal liver, renal, and thyroid functions. Participants continued their regular medications, if any, during the study.
Participants were assigned by the MGH Research Pharmacy to receive either placebo or sulforaphane according to computer-generated randomly permuted blocks of three assignments, with sulforaphane and placebo treatments allocated in a 2:1 ratio in two strata defined by parent-reported history of improvement in behavior during febrile illness. Physicians and study staff were blind to group assignment. Forty-four subjects were selected to provide at least 80% power to test the primary hypothesis for the SRS using a two-tailed two-sample t test with α = 0.05 and assuming that the true difference in average change in SRS was 15 units with a SD of 16 units. This is roughly twice the average magnitude of natural change observed over 1 y among male children and adolescents with ASD (38).
The study comprised seven visits: screening, randomization, and start of treatments, at 24 h, and at 4, 10, and 18 wk after the first dose. Treatment was discontinued after the 18-wk visit, and participants returned at 22 wk. Medical history, physical examination including vital signs, adverse event reporting, and SRS, ABC, and CGI-I were performed (Fig. 1). At the 4-, 18-, and 22-wk visits, hematology, chemistry, and urinalysis were also obtained.
All families were contacted after the final participant completed follow-up and asked for their impressions of the study and their child's progress while under treatment. Families were then informed whether he received sulforaphane or placebo.
Administration of Medication and Protocol Schedule.
Capsules of sulforaphane-rich broccoli sprout extracts were maintained at −20 °C, and checked periodically microbiologically and for sulforaphane titer (SI Materials and Methods) (8). Indistinguishable placebo capsules contained microcrystalline cellulose. Sulforaphane or placebo was administered daily for 18 wk. The participants were dosed according to body weight: 50 µmol (one capsule) of sulforaphane for <100 lb, 100 µmol (two capsules) for 101–199 lb, and 150 µmol (three capsules) for >200 lb. Placebo recipients received equivalent numbers of capsules according to their weight. Capsules were dispensed to participants in sealed bottles by the MGH Research Pharmacy, with instructions to keep them in a household freezer.
Behavioral Outcome Measures.
The ABC is a parent- or caregiver-reported 58-item questionnaire designed to assess medication effects; each item is scored on a scale of increasing severity from 0 to 3 (27). ABC also assesses several subdomains (irritability, lethargy, stereotypy, and hyperactivity).
The SRS is a parent- or caregiver-reported 65-point social communication questionnaire that covers five subscales (awareness, cognition, communication, motivation, and autistic mannerisms) (28). Each SRS item is rated on a scale of 1–4; the total score was our primary efficacy endpoint.
The Ohio Autism Clinical Global Impression Severity Scale (CGI-S, also designated OACIS-S, and only measured at screening) (29, 30) is a clinician-rated assessment of the severity of autistic behavior (in increasing order of severity from 1 to 7) and includes the following subdomains: global autism severity, social interaction, aberrant behavior, repetitive or ritualistic behaviors, verbal and nonverbal communication, hyperactivity/inattention, anxiety, sensory sensitivities, and restricted/narrow interests. The Ohio Autism Clinical Global Impressions Improvement Scale (CGI-I or OACIS-I) (29, 30) is a clinician-rated assessment of how much the patient's behavior has changed during an intervention.
Statistical Evaluation.
Forty-four subjects were originally enrolled and randomized to sulforaphane treatment (n = 29) or placebo (n = 15); four subjects discontinued participation in the study before the first (4-wk) return visit. Behavior scores for the remaining 40 participants, who completed at least part of the outcome measure evaluations (14 placebo and 26 sulforaphane), are described in our primary results and shown in Figs. 2–4 and Tables 1 and 2. To compensate for incidental changes in ABC/SRS scores resulting from normal fluctuation, we obtained these scores at both screening and randomization visits, and used their averages to compare with subsequent ABC/SRS scores. Our primary analysis used the differences between scores of individuals at 4, 10, 18, and 22 wk from their respective average pretreatment values. The test of our hypothesis was the difference between the sulforaphane and placebo treatment groups in the change in ABC and SRS scores from baseline to 18 wk, and their reversion to baseline at 22 wk.
Each outcome was modeled in a shared-baseline mixed-effects general linear model with fixed effects for visit and the interaction of postrandomization visit and treatment group and random participant-specific intercepts and slopes with unstructured covariance. The absence of a main effect for treatment (i.e., a "shared baseline") properly reflects the true state of the population sampled before randomization and has the advantage of adjusting for any chance differences at baseline in a manner similar to ANCOVA (39). Linear contrasts of least-square means were used to estimate changes from baseline between treatment and control groups at each follow-up visit. Given its assumptions, the mixed model yields estimates that are unbiased as long as loss to follow-up, and missing test scores are predictable from observed scores under assumptions of the model. An intention-to-treat analysis that included all 44 participants led to similar conclusions (SI Materials and Methods).
Statistical analyses were performed with SAS v. 9.3 software (SAS Institute), and Stata v.11.2 (Statacorp).
We thank the participants and their families who were consistently interested and gave generously of their time; Scott Zeger for discussions on biostatistics; Jessica Helt and Karmen Koesterer for patient testing and Luisa Masclans for data collection; Ann Neumeyer, who chaired the Data Safety Monitoring Board and was consulted regarding safety and side effects; Jennifer Mullett for assisting with study procedures; and Christine Ferrone and Lisa Nowinski for advising us on regulatory matters and outcome measures. The quality of data collection, retrieval, and analysis were certified by Quality Associates Incorporated. The study was supported by gifts from the Nancy Lurie Marks Family Foundation, the Hussman Foundation, the Lewis B. and Dorothy Cullman Foundation, the Agnes Gund Foundation, the N of One Foundation, and the Brassica Foundation for Chemoprotection Research.
- ↵1To whom correspondence may be addressed. Email: ptalalay{at}jhmi.edu or Andrew.Zimmerman{at}umassmemorial.org.
Author contributions: K.D.S., P.T., and A.W.Z. designed research; K.S., S.L.C., and A.W.Z. performed research; J.W.F. and P.T. contributed new reagents/analytic tools; K.S., E.A.M., J.W.F., P.T., and A.W.Z. analyzed data; K.S., K.D.S., J.W.F., P.T., and A.W.Z. wrote the paper; and J.W.F. and P.T. supplied sulforaphane-rich broccoli sprout extract.
Reviewers: B.H.K., Seattle Children's Autism Center; R.K.N., University of California, San Diego; and C.G., University of Southern California.
Conflict of interest statement: U.S. patent applications have been filed by The Johns Hopkins University (inventors K.D.S., P.T., and A.W.Z.). P.T. and A.W.Z. have divested themselves from all potential financial benefits. The sulforaphane-rich broccoli sprout extract is not a commercial product. Broccoli sprouts and seeds rich in glucosinolates have been licensed by Johns Hopkins to Brassica Protection Products LLC (A. Talalay, son of P.T., is chief executive officer).
This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1416940111/-/DCSupplemental.
Freely available online through the PNAS open access option.
- ↵.
- American Psychiatric Association
- ↵.
- Developmental Disabilities Monitoring Network Surveillance Year 2010 Principal Investigators,
- Centers for Disease Control and Prevention (CDC)
- ↵.
- Zhang Y,
- Kensler TW,
- Cho CG,
- Posner GH,
- Talalay P
- ↵.
- Zhang Y,
- Talalay P,
- Cho CG,
- Posner GH
- ↵
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- Egner PA, et al.
- ↵
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- James SJ, et al.
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Citation Manager Formats
Article Classifications
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Hereditary Hair Loss In Men
What Is Hereditary Hair Loss
Male Hereditary Baldness (correct name Androgenetic Alopecia) is the reason why 95% of us lose our hair to varying degrees.The remaing 5% of men who lose their hair do so because of stress, medication, or other health conditions.
The symptoms of Hereditary baldness are quite easy to identify, and are prety predictable. The first thing to show is the receding of the hairline, usually at the temples and brow, the crown will also begin to thin, quite often the sides and the back show no effect and stay as they are.
Hairloss in other family members can be a guide as to the severity of the problem, but there are other factors that have an effect: age and levels of testosterone are thought to play a major part in herediatry hair loss.
Can Hereditary Hair Loss Be Treated
Despite what some people say, if you are not ready to embrace baldness, there are ways to slow and in some cases stop the hairloss. The important thing to do is to increase the bloodflow to the follicles, this will help stimulate secondary hair growth and will also strengthen your existing hair.
Cure For Male Pattern Baldness
What Can I Do
Have a look at Profollica, now available to UK customers; it is the USA's biggest selling hairloss treatment.
How Does Profollica Work
Profollica works to discourage the excess production of DHT. This is a naturally made compound (full name dihydrotestosterone) that is found in us all. In men suffering with Hairloss, this is produced in higher than normal levels and this excess actually poisons the follicles, initially shrinking them and eventually closing them up completely.
But there is more to encouraging hair regrowth than reducing the production of DHT, it is also crucial to create the best conditions to encourage effective hair regrowth.
Profollica uses a proven three step program to encourage powerful hair re-growth
Step 1 — Inhibits The Production of Excess DHT with a daily supplement that nourishes the body with our patented, medically approved formulation of 100% natural herbals.
Step 2 — Eliminates Harmful Scalp Bacteria with the scalp purifying shampoo that actually helps to gently eliminate more serious scalp issues like dandruff, psoriasis, oily hair, itchy scalp and MORE!
Step 3 — Encourages Fast, Healthy Growth with the follicle stimulator ( The Activator Gel), which is sprayed at the roots of the hair after each shampoo.
Results in the USA have been staggering, the majrity of users have reported seeing their hair begining to re-grow within 30 days of use, with more significant results seen after 60 days of use!
Naturally everybody is different, and results will vary from man to man, however based on the clinical trials and medical testimonials that fully recommend and approve Profollica, it certainly seems to be head and shoulders above any other hair treatment.
Where Can I Buy Profollica
Profollica can be purchased from the official website, orders are shipped worldwide, quickly and discreetly. orders are sent out with a full 60 day cash back guarantee, the makers say that if it doesnt work as they know it will, simply return any unused product for a full refund.
Priced In USD $ on the website, a months supply of Profollica (which is certainly long enough to see some amazing results) costs out at USD$ 59.99 – at current conversion rates, this equates back to GBP£ 36.51 for UK customers.
What have You Got To Lose?
Buy The Clinically Approved Profollica System Today


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+966 12 676 0000 Ext.2403, 2405, 5557
email: email@example.com
Faiza Rizvi
Saudi Gazette
JEDDAH — There was a time when Saudi women were perceived as oppressed and were known to be hidden behind the veil. But the last few years have witnessed an elevation in the status of Saudi women, who are boldly stepping up and challenging social norms to make a mark for themselves in the society.
When Lulwa AlSoudairy, launched Artistia.com 4 months back, with her cofounders Leena Al-Aufi and Marwan Cheguenni, she had an exceptional vision of promoting Arab designers and artists, which she is now determined to turn into reality. After graduating from Dar AlHekma University, she went on to pursue her MBA from Babson College. Artistia won the second position in the startup track with great appreciation from the judging panel at the recently concluded MIT Enterprise Forum, competing among 1000 entries from all over the Kingdom.
Artistia.com is an online social marketplace where one can directly purchase diverse items such as jewelry, clothes, Abayas, furniture and other unique products directly from their favorite artists and designers from the Middle East. "Western brands sell most in the Kingdom, while local designers have limited platforms to showcase their talent. They either create social media accounts to promote their creations or look for local bazaars," AlSoudairy told Saudi Gazette, adding that she wanted to create a medium where Arab designers would get a chance to reach customers with their creations easily, because they analyze and understand customer preferences and taste in the Kingdom more than international brands do.
"It is an excellent platform where these designers can showcase and sell their art, collaborate with one another and get access to experts who can help them grow professionally," said AlSoudairy. What's unique about this online marketplace is the creation of a centralized hub for artists, where they can easily register, get to sell their artwork and collaborate with each other through a customized app on the website. As the sales will increase, this will gradually lead to an increase in demand for their goods, both locally and internationally, which will trigger growth in local production, thereby leading to a productive economy. Artistia aims to build, on a historical heritage, a modern platform that fosters the new generation of artists and designers. The inspiration of manifesting local creations on an international platform came from her mother, who has been a handicraft artist for over 10 years, but faced numerous challenges of selling her products due to absence of concrete media back in those times.
Her website has already registered over 60 professional designers in just a span of 4 months, to whom AlSoudairy eventually wants to expose to international recognition.
Giving her opinion on the changing status of Saudi women, AlSoudairy remarked: "Last 5 years have been a time of transformation for Saudi women and studies reveal that 40% businesses are owned and managed by them. I've noticed that Saudi women love to challenge themselves and are very hard-working and I'm not just saying that because I'm one of them."
AlSoudairy is supported by an inspired team of young hardworking individuals who are working to fulfill the vision of Artistia, including Hassan Cheguenni, Nermeen Ekramy, Shahad Qari and Noura Al-Aufi.
Picture Caption: Lulwa Al-Soudairy and Nermeen Ekramy receiving their prize at the recently concluded MIT Enterprise Forum for Artistia.com


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A sports technology platform made for athlete success
Whether you're a part of a sports organization, school, team or you're an individual athlete or coach, Athlete Builder has you covered.
Watch video
With Athlete Builder you get everything you need to learn, collect data, analyze your progress and take control of your athletic goals!
Learn progressivelyWe have the content and tools to ensure learning never stops as an athlete, coach or athletic administrator.
Collect dataCollect and store performance, strength and learning data to produces actionable insights for athlete development.
Analyze outcomesQuickly analyze your data and identify opportunities for athletic and personal improvement, competition, and team building.
We strive to help you build better athletes and better people with sports technology.
For organizations - build a more aligned athletic program
Youth organizations, clubs and schools use Athlete Builder to better align all sport teams; no matter their level. We provide tools for continual learning, multi-team/school accountability and advanced reporting features. We help you take control of every sport and team in your athletic program.
For sports teams - build a strong data-driven team culture
Single sport teams use Athlete Builder to help train, manage and track both athletic development and learning across the entire team. Use data to discover areas where you need to improve and hold both your athletes and coaches accountable with team analytics.
For individuals - build a better athlete, better person
Individual athletes, parents and coach educators use Athlete Builder to help improve overall athletic development while understanding the true value of sport. Our goal is to build future leaders through youth sports and show athletes how to handle critism and persevere when facing obstacles.


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This week on Beer America TV we head to the evil House Lannister, and the family that ruled Westeros at the conclusion of season two of the HBO hit series Game of Thrones! In collaboration with HBO, Brewery Ommegang created Iron Throne Blonde Ale to match the color of Lannisters' hair. Brewed with noble hops, grains of paradise and citrus peel, there is certainly a little bite that goes along with the malty fruitiness of this excellent beer! Not familiar with the series? No worries, this beer stands on it's own Thrown quite comfortably!
Brewery Ommegang: Iron Throne, Ep. 185
on April 10, 2013 |
1 Response
Ray Larkin Said,
Best comment, "it does not bite".


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Majestic Shuttle
Dennis Lohaus wrote and performed this song in tribute to the Space Shuttle Team and Our Astronauts. Dennis has been part of the Shuttle Program for 31 years as an Engineer. With the shuttle program coming to an end, he and thousands of others are saddened and disappointed to hear the program will no longer be part of our American Dream and Inspiration.


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Divine Divinity skills X at RPGVault
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Divine Divinity skills X at RPGVault
Game News - posted by Ibbz on Tue 29 October 2002, 07:47:46Tags: Divine Divinity; Larian Studios
RPGVault have posted their 10th feature on the skills featured in Divine Divinity. This one cover the "Way of the warrior - Path of the Ranger" and includes quite a detailed description of various skills related to the Warrior/Ranger. Here's a piece:
Way of the Warrior - Path of the Ranger
Elven Sight (Passive)
Skill description
You can see further and thus target and attack your enemies from afar.
In-game stats
Level 1: Increase sight range by 2. Required Clvl: 1
Level 2: Increase sight range by 4. Required Clvl: 5
Level 3: Increase sight range by 8. Required Clvl: 9
Level 4: Increase sight range by10. Required Clvl: 13
Level 5: Increase sight range by 12. Required Clvl: 17
Spotted at RPGDot.
There are 1 comments on Divine Divinity skills X at RPGVault


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Black Diamond Mercury Mitt
A pair of high quality mitts are an essential item in any rucksack when venturing into sub-zero temperatures. Don't lose the use of your hands when it really matters.
Temperature Range: -29ºC to -12 ºC | Weight: 324g
Insulated Cold Weather Gloves
When the weather's cold you need a good quality well-constructed waterproof glove that will perform in all conditions.
Insulation: Primaloft® or simular synthetic insulation
Sealskinz High Vis All Weather Cycle Gloves
This all weather cycle specific glove is protective, comfortable and dextrous, with pressure point padding and box finger construction. It is lightweight, totally waterproof, breathable and windproof.
Weight: 375grm
Sealskinz Fingerless Summer Cycle Gloves
These fingerless summer cycling gloves are an excellent road cycling glove, giving superb fit due to a stretch fabric back and comfort through the padded palm.
Weight: 200grm
Sealskinz Thermal Liner Gloves
These Sealskinz Thermal Liner Gloves are designed to be worn either by themselves or with other gloves to give an additional thermal layer of insulation. Made with Merino wool for extra comfort and wicking performance.
Fit:Close fitting | Material:Merino wool
Hot Hands Hand Warmers - 5 Pairs
Keep your hands warm wherever you are with HotHands
hand warmers. This pack of 5 pairs of hand warmers provides quick and easy warmth for up to 10 hours of heat.
Weight: 250 grm


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Reclamation Bureau's water recycling and reuse funding criteria published
The US government's Bureau of Reclamation published on 15 October 2010 the funding criteria under its Title XVI - Water Recycling & Reuse Program for two new funding opportunity announcements in fiscal year 2011.Following public comment, the final funding criteria and a compilation of the public comments received are available online.
This fall, two funding opportunities will be posted at www.grants.gov. One opportunity will be open for construction of Title XVI projects, while a second will provide cost-shared assistance for the development of feasibility studies under the program.
Title XVI of PL 102-575 provides authority for Reclamation's water recycling and reuse program and is focused on identifying and investigating opportunities to reclaim and reuse wastewaters and naturally impaired ground and surface water in the 17 Western States and Hawaii. Title XVI projects have the potential to stretch water supplies using both time-tested methodologies and piloting new concepts.
WaterSMART is a program of the US Department of the Interior that focuses on improving water conservation and helping water-resource managers make sound decisions about water use. It identifies strategies to ensure that this and future generations will have sufficient supplies of clean water for drinking, economic activities, recreation, and ecosystem health. The Program also identifies adaptive measures to address climate change and its impact on future water demands.
© Faversham House Group Ltd 2010. Water. desalination + reuse news articles may be copied or forwarded for individual use only. No other reproduction or distribution is permitted without prior written consent.


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Important Update:
2019 ALBERTA HCA CURRICULUMExpand
The Alberta Government has recently updated the Health Care Aide curriculum to align with the new Alberta Health Care Aide Competency Profile, 2018 that replaced the Health Care Aide Competency Profile (2013). The 2018 Health Care Aide Competency Profile outlines the knowledge, skills, behaviors and attitudes required by all Health Care Aides who deliver care in Alberta.
To keep abreast with the current global trends and relevant standards on health care, the provincial curriculum of Health Care Aide in Alberta is also updated.
Beginning in Winter 2020 the Alberta Health Care Aide program when taken full time is completed in eight (8) months.
A new admission requirement will be implemented in Winter 2020 that requires a minimum of 60% in English Language Arts 20-2 or its equivalent.
June 30, 2020 is the cut off date to graduate under the older curriculum.
You may receive further information about changes of the Health Care Aide program once we get the approved new Alberta HCA curriculum. Please complete the attached form.
Why MTG Healthcare Academy?
- Government of Alberta Health Care Aide
(HCA Provincial Curriculum)
- Flexible schedules
(Days, Weekends & Evenings)
- Stress-Free and fun institutional
learning environment
- Administrative staff that are
accommodating and approachable
- Highly qualified staff and
motivational instructors
- Personal and One-on-One
- Resume and
job search help
- Financial assistance to those
who qualify
Welcome to MTG Healthcare Academy
Register in our Health Care Aide program and join the thousands of passionate healthcare providers that are working in the hospitals, nursing homes, retirement homes and private homes across the country!
Want to learn more about our Alberta Health Care Aide Program? Click here for our course listings.
MTG Healthcare Academy
seeks to be the training school of first-choice – the leading private vocational institution fostering excellence in the pursuit of knowledge while engendering personal integrity and social responsibility in the field of health care.Learn More


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In this study, Brian Hand blends theological analysis with literary observations to show how Revelation serves as the perfect conclusion to the Bibles depiction of Jesus Christ. A careful look at Revelations time and space, characters, literary figures, structure, and plot points distinctly to Jesus Christ as the perfect Prophet, Priest, and King and as uniquely worthy of worship. Hands synthesis of individual literary elements with Christology invites further study of Revelation from a literary perspective.
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Cadbury Australia: Sparking a National Flavour DebateAU
The oPPORTUNITY
@CadburyAU had four new chocolate flavours launching into the market. Included in these new offerings was one flavour that was guaranteed to get people talking: the combination of two of Australia's most loved brands – Cadbury Dairy Milk milk chocolate with Vegemite spread. @CadburyAU turned to Twitter to get consumers talking about the new products and build buzz around Cadbury Dairy Milk with Vegemite.
The strategy
Knowing that Australians are passionate about sharing their favourite flavours, @CadburyAU went to consumers to ignite a flavour conversation. @CadburyAU used Twitter Ads to build conversation and engagement over six weeks. Using Promoted Tweets with the hashtag #ChocPlusWhat, the campaign asked Australians about their favourite foods to combine with chocolate, presenting possibilities such as corn chips, avocado and lime jelly. A number of days into the campaign, @CadburyAU leveraged this flavour conversation to announce their own four new flavour combinations, spacing the announcements a day apart to allow buzz to grow. The most talkable addition – Cadbury Dairy Milk with Vegemite – was left until last to drive even more buzz.
Four steps to success
1. Use rich media to invite conversation and increase engagement.
@CadburyAU used simply designed, but eye-catching images showing possible food + chocolate combinations, along with a question mark, to invite audience suggestions for new flavours and drive conversations around the topic. The #ChocPlusWhat hashtag complemented and reinforced the message – @CadburyAU wanted to spark conversations with people and encourage them to share their ideas and opinions on the proposed flavours. Promoted Tweets inspired a wave of user-generated content, which included a range of flavour combinations, from the tasty to the bizarre and humorous.
2. Continually monitor conversation to convert influencers and consumers into brand advocates.
@CadburyAU used real-time monitoring to engage with Cadbury Twitter fans, as well as media outlets, celebrities and influencers. This provided a chance to engage in high-profile banter with the presenters of The Project(@theprojecttv) and Retweet mentions from Nine News (@9NewsAUS), among other media sources. The brand sent gift packages of the new products to key influencers and fans @CadburyAU encouraged feedback and ensured thank-yous received public acknowledgement.
3. Use Twitter tools to optimise the campaign in real time.
@CadburyAU observed that the multi-picture format visuals achieved extremely high engagement rates and vastly out-performed single-picture format graphics. This inspired the creation of more multi-picture format graphics for use as the campaign continued, raising overall campaign engagement rates further.
4. Take advantage of buzz to send a campaign viral.
Before the campaign began, @CadburyAU seized the opportunity presented when a Buzzfeed Australia article speculated on a rumour about the new Vegemite flavour. Straight after the announcement of Cadbury Dairy Milk with Vegemite, the company Tweeted the article's author to confirm the rumour. This sparked viral coverage and accelerated the Twitter conversation around the announcement – which spread globally.
@CadburyAU's plan was to ignite conversation around the new flavours. The simple campaign mechanics captured audience imaginations, with Twitter users contributing to the conversation by creating their own graphics with new flavour ideas. This helped to drive awareness of the new products and widened audience engagement as people shared their creations with friends and family.
The Australian Twitter audience participated enthusiastically in the request for favoured chocolate combinations – especially during the 10-day peak campaign period, with the majority of the 890,600 impressions achieved during this time. The engagement rate for the entire campaign was 11.07% – well over the benchmark of 3.35% for the quarter in the Food category – with individual Tweets gaining up to 15.62% engagement rate. In the last 10 days of the campaign, the creation of user-generated content went viral, with Twitter users around the world offering thoughts on their own perfect Cadbury chocolate combinations.
The day after the announcement of Cadbury Dairy Milk with Vegemite,#ChocPlusWhat trended organically on Twitter. Newspapers and media sites, such as Buzzfeed Australia and US and The Daily Mail UK, ran the story across the country and around the world.
"The use of Twitter saw media and news publications use the @CadburyAU handle as a new source for content, interacting with Cadbury in engaging one-on-one conversations. Our Twitter interactions resulted in newspapers picking up the story: with Cadbury's Tweets embedded on news media websites around the world, driving exponential traffic and positive brand exposure."Paul Chatfield Associate Director Marketing - Chocolate ANZ, Mondelez Australia


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The Nystagmus Network encourages our fundraisers to get online and set up a Justgiving page to manage their sponsorship. It's quick and easy to do. Your sponsors will be confident that it's a well-recognised online fundraising platform, you won't have to do anything else as the funds you raise will get transferred directly to us and we can collect 25% Giftaid automatically on all eligible donations, which means the total you raise for nystagmus will grow even bigger.
To get started just go to Justgiving here or click the logo below and open an account. You'll find the Nystagmus Network listed under participating charities.
That's what Jac did when he ran a 2.5k junior run for us on Nystagmus Awareness Day. He raised £745 for the charity, plus £108.50 in Gift Aid.
Well done, Jac!


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A rigid self-adhesive system.
Cambrian Plastics are stockists and distributors of Easy Glaze, which is an inexpensive and easy to use self-adhesive 2 part DIY glazing system specifically designed for use with 3mm thick Plastic Glazing Sheets. We do NOT recommend use of glass with this particular secondary glazing product.
Click through for details of all the DIY Glazing systems we offer.
The EasyGlaze base strip is cut and fixed to the window frame with tape, the glazing sheet being held in by the matching cover strip, which is pressed in providing a neat and attractive appearance. The profiles can be mitred to form a frame, using the mitre bead provided with a few simple tools.
Because Easy Glaze uses self-adhesive tape, we recommend cleaning and degreasing the window surround before installation.
Easyfix Surface Preparation Wipes are ideal for this, containing 70% Isopropyl Alcohol (IPA).
See the table below for pack details.
We recommend using 3mm Acrylic sheet with EasyGlaze or 4.5mm can be used for larger windows if extra rigidity is required.
We offer a full cut to size service to provide you with all your acrylic panels.
For Double Glazing we only use Plexiglas branded acrylic, a high quality sheet with a 30 year guarantee.
• Plastic sheet only
• Self-adhesive fixing
• Smart appearance
• 3mm glazing
Easy Glaze – 1x 2440mm Length White or Brown $46.10 GST
Mitre Block – 1x Block $10.00 GST
- A tooth saw
- Mitre Block
- Pencil
- Tape measure


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Train Light
When I pack, and I often do, I always hesitate when it comes to taking my trainers. Why? Because I always feel that they are heavy and I am constantly worrying that my luggage will be overweight.
I have now mastered it, or so I thought, using my Sketchers, but along came these three choices from Nike, New Balance and Adidas, which I intend to try out soon. Let me know if you have tried any of these and if they really are light, but usable.
By the way, I use my trainers to keep fit by dancing.
Photo: mbuy-sn-k.com
Related Posts
Category: Culture & Society, Delia Dolor, Delia's Escapades
About the Author (Author Profile)
Delia Dolor is an all-round media professional. She produces and presents television, radio and live shows. She is also a public speaker, magazine and print editor.
Delia has been credited with creating a more intimate confessional form of media communication and to have influenced the way talk shows in the Caribbean can influence the lives of others.


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Always something new and at times something quite different !
Playing now on Australian Country Radio is a new song from a new band, Colt Seavers Band, "Walk The Floor"
Colt told Australian Country Radio,"We have the upright Bass and try to bridge the gap between Country and Rockabilly. We are a fun band, but serious about entertaining people,I think a lot of people have never seen a Double Bass before but with the hipster movement gaining momentum, most of our crowd are very young and it's brought back the Bluegrass and Hillbilly music and we play anything - Countrybilly, Rockabilly and Bluesabilly.
Listen to Australian Country Radio 24/7 on the free Google Play app. TuneIn Streema Facebook RadioFM and at our website www.auscountry.com.au


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The Gulf Cooperation Council expressed rejection to foreign interference in the Iraqi crisis, in reference to Iran's direct involvement in Iraq's war against ISIS, during a meeting held in Riyadh on Thursday.
"The GCC Arab States confirm their support for Iraq's unity and territorial integrity and for the Iraqi government to help it for maintaining security and stability in Iraq, and non-interference in its internal affairs and extending its sovereignty over all its territory," said Qatari Foreign Minister Khalid al-Attiyah who chaired the session, in statements carried by the Saudi Press Agency (SPA).
Read the full text news in resource site…
Source News: Al Arabiya News
Photo: Peter Kovessy


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ADAPALENE; BENZOYL PEROXIDE (a DAP a leen; BEN zoe ill per OX ide) is used on the skin to treat acne.
This medicine is for external use only. Follow the directions on the prescription label. Cleanse the affected area with a mild or soapless cleanser and pat dry. Apply a thin layer of medicine to the affected area. Rub in gently. Do not get in the eyes, on the lips, or on any other areas of sensitive skin. Use your medicine at regular intervals. Do not use it more often than directed.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
severe burning, redness, crusting, or swelling of the treated areas
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
increased sensitivity to the sun
inflamed, stinging, and irritated skin
skin that peels after a few days of use
other acne medicines
salicylic acid or sulfur containing products
topical antibiotics like clindamycin or erythromycin
If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light. Keep container tightly closed. Throw away any unused medication after the expiration date.
They need to know if you have any of these conditions:
seborrheic dermatitis
skin abrasions
an unusual or allergic reaction to adapalene, benzoyl peroxide, vitamin A, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
Your acne may get worse at first, and then should start to get better. It may take 2 to 12 weeks before you see the full effect.
Do not use products that may dry the skin like medicated cosmetics, products that contain alcohol, astringents, spices, limes, or abrasive soaps or cleaners. Do not use other acne or skin treatments on the same area that you use this medicine unless your doctor or health care professional tells you to. If you use these together they can cause severe skin irritation.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
This medicine may bleach hair or colored fabrics. Avoid getting the medicine on your clothes.
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thinkstep is a global sustainability software company with over 250 sustainability and compliance experts in 28 offices across 16 countries. 40% of the Global Fortune 500 companies rely on thinkstep software solutions. For example, thinkstep provides the leading life cycle assessment software GaBi which has 20,000 users in more than 20 different industry sectors. Further details about thinkstep can be found at www.thinkstep.com.
With a single source for material data, we now spend less time searching for the right materials. Our materials are now directly accessible from the design and simulation tools and easy to find. We can ensure to have the same, reliable material information in all steps of the PLM process and respect compliance and resource efficiency already in the MCAD / ECAD environment. The advantages are so obvious that it's nearly absurd to spell them out.
Head of Components and Vacuum Technology
Siemens Healthineers
With Teamcenter Substance Compliance, we efficiently address our environmental compliance needs while improving our business processes to save time and money.
Head of Environment, Health and Safety
WAGO Kontakttechnik GmbH & Co. KG
Teamcenter integrated material management is the platform to standardize material processes across the enterprise and across business functions, to enable steering, transparency and information exchange for all technical material aspects.
Head of Corporate IT Laboratories, Simulation
BSH Hausgeräte GmbH
BOMcheck has the simplest input interface we have seen and provides extensive help and data checking to reduce errors and highlight potential issues while you are working on your part declarations.
GE Healthcare Newsletter to Suppliers
BOMcheck is the first system that allows OEMs to reduce the industry burden of REACH and RoHS compliance by compiling a centralised master database of substance data from suppliers.
Head of Environment, Health, Safety
Siemens Healthineers
Over the years, GaBi Life Cycle Assessment software has become a core tool for product- and process-related environmental activities at Volkswagen. Linked to the company's IT systems, GaBi provides the VW experts with detailed data for strategic decisions.
Head of Product and Environment
Volkswagen AG
GaBi gives us the data to assess and reduce the environmental impact of a product throughout its entire life cycle.
Director of Marketing
The EC4P WEEE and Batteries recycling compliance management service is indispensable in complying with product recycling regulations across Europe. By using the EC4P service, the burden of compliance, in terms of cost and time, is significantly reduced in what is a constantly-changing situation across EU Member States and EFTA countries.
HSE Director
Meggitt Sensing Systems
In my experience, EC4P is a unique differentiator that allows Nutanix to meet its compliance requirements without the need, expense and complexity of hiring compliance personnel in all 28 EU Member States. EC4P has a well-established, auditable, programmatic path to compliance that allows us to quickly start selling into EU member states in a matter of a few weeks as our business expands. The process is very lightweight and flexible.
VP Operations


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« PreviousContinue »
o o iño **** Two FRENCH REVOLUTIONARY ORATORS
2// so 2. Robespierre the elegant orator is dressed suitably to his time. Danton the fiery orator is addressing the o o:---- so from the tribune. Both lived in the most exciting times of French History. Their orations are S.I As - -- nteresting as portraying the underlying principles of the great French Revolution. -
2. Jean Paul Marat whose portrait is shown, was a popular leader in the French Revolution. This picture -** shows his assassination by Charlotte Corday, who in turn suffered death by the guillotine. His 'onor was marked by blood-shed and violence. His oratory was of a type suited to such"troublesome time.
of men the most vile, and of wretches the most detestable; men who continue to imagine that the Revolution has been made for themselves alone, and who have sent Louis XVI. to the Temple, in order that they may be enthroned at the Tuileries It is time to break these disgraceful chains— to crush this new despotism. It is time that those who have made honest men tremble should be made to tremble in their turn.
I am not ignorant that they have poniards at their service. On the night of the second of September—that night of proscription 1–did they not seek to turn them against several deputies, and myself among the number 1 Were we not denounced to the people as traitors' Fortunately, it was the people into whose hands we fell. The assassins were elsewhere occupied. The voice of calumny failed of its effect. If my voice may yet make itself heard from this place, I call you all to witness it shall not cease to thunder, with all its energy, against tyrants, whether of high or low degree. What to me their ruffians and their poniards? What his own life to the representative of the people, while the safety of the country is at stake 2
When William Tell adjusted the arrow which was to pierce the fatal apple that a tyrant had placed on his son's head, he exclaimed, "Perish my name, and perish my memory, provided Switzerland may be free l'' And we, also, we will say, "Perish the National Assembly and its memory, provided France may be free."* Ay, perish the National Assembly and its memory, so by its death it may save the Nation from a course of crime that would affix an eternal stigma to the French name; so, by its action, it may show the Nations of Europe that, despite the calumnies by which it is sought to dishonor France, there is still in the very bosom of that momentary anarchy where the brigands have plunged us—there is still in our country some public virtue, some respect for humanity left| Perish the National Assembly and its memory, if upon our ashes our more fortunate successors may establish the edifice of a Constitution, which shall assure the happiness of France, and consolidate the reign of liberty and equality
* When these words were spoken the deputies rose with intense enthusiasm and repeated the words of the orator, while the audience in the galleries added their cries of approval to the tumult on the floor.
ARGE of frame, dauntless of spirit, passionate of temperament, L powerful in voice, Danton was well adapted for political orai tory and revolutionary times. In quiet days he would not have shone, but in the whirlpool of the French Revolution he was at home, while his fervid and splendid oratory made him the favorite of the Parisian populace. "Nothing was wanting to make Danton a great man—except virtue," said Lamartine, and this well describes him. His famous sayings: "To dare, again to dare, always to dare," and "Let France be free, though my name be accursed," speak vol. umes for the boldness and patriotism of the man. Before men like him, and sentiments like these, the old institutions could not stand. The club founded by him, that of the Cordeliers, was more radical even than that of the Jacobins. For a time, Danton, Marat and Robespierre ruled the Revolution. Then a break took place between them, and while Danton hesitated Robespierre acted. The natural result followed, the guillotine became his fate.
[The disasters of the French armies on the frontier called out from Danton in the Convention, March Io, 1793, one of his most impassioned addresses. Of this we give the telling closing portion, in which occurs one of his most famous sentences.]
The general considerations that have been presented to you are true; but at this moment it is less necessary to examine the causes of the disasters that have struck us than to apply their remedy rapidly. When the edifice is on fire, I do not join the rascals who would steal the furniture, I extinguish the flames. I tell you, therefore, you should be convinced by the dispatches of Dumouriez that you have not a moment to spare in saving the Republic.
Dumouriez conceived a plan which did honor to his genius. I would render him greater justice and praise than I did recently. But three months ago he announced to the executive power, your General Committee of Defence, that if we were not audacious enough to invade Holland in the middle of winter, to declare instantly against England the war which actually we had long been making, that we would double the difficulties of our campaign, in giving our enemies the time to deploy their forces. Since we failed to recognize this stroke of his genius, we must now repair our faults. Dumouriez is not discouraged ; he is in the middle of Holland, where he will find munitions of war. To overthrow all our enemies, he wants but Frenchmen, and France is filled with citizens. Would we be free ? If we no longer desire it, let us perish, for we have all sworn it. If we wish it, let all march to defend our independence. Your enemies are making their last efforts. Pitt, recognizing he has all to lose, dares spare nothing. Take Holland, and Carthage is destroyed, and England can no longer exist but for liberty Expediate, then, your commissioners; sustain them with your energy; let them leave this very night, this very evening. Let them say to the opulent classes, "The aristocracy of Europe must succumb to our efforts and pay our debt, or you will have to pay it !" The people have nothing but blood, they lavish it ! Go, then, ingrates, and lavish your wealth ! See, citizens, the fair destinies that await you. What ' You have a whole nation as a lever, its reason as your fulcrum, and you have not yet upturned the world ! To do this we need firmness and character, and of a truth we lack it. I put to one side all passions. They are all strangers to me save a passion for the public good. In the most difficult situations, when the enemy was at the gates of Paris, I said to those governing: "Your discussions are shameful, I can see but the enemy. You tire me by squabbling in place of occupying yourselves with the safety of the Republic I repudiate you all as traitors to
our country ! I place you all in the same line !" I said to them : "What care I for my reputation | Let France be free, though my name were accursed ' ' ' What care I that I am called a "blood-drinker '' .
Well, let us drink the blood of the eaemies of humanity, if needful ; but let us struggle, let us achieve freedom. Some fear the departure of the commissioners may weaken one or the other section of this convention. Vain fears l Carry your energy everywhere. The pleasantest declaration will be to announce to the people that the terrible debt weighing upon them will be wrested from their enemies or that the rich will shortly have to pay it. The national situation is cruel. The representatives of value


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KC Scavenger Hunt!
Heads up, KCMO!
Squeezebox is preparing a Kansas City-sweeping scavenger hunt – a great opportunity for you to learn more about our incredible city, and a chance to win a pretty cool prize package.
The date (and prize!) will be announced on our site and social media pages soon… keep on-a-checking!
How it works:
We will post photos. You identify them.
The first person to submit all the correct answers to email@example.com will be crowned King/Queen of the Squeezebox Scavenger Hunt. We will have a fun little award ceremony (maybe you 2nd and 3rd place winners get a little something, too). We'll also feature you in our blog feed. You'll be famous!


text: Looking at the code, you are clearly correct. I had largely forgotten about that problem. We need at least minimal atomic_ops support for mips. If someone can adapt, for example, cris.h in the atomic_ops-1.2 part of the tree, that should be sufficient for at least basic functionality. I might be able to try, but I'm not sure I still have access to a machine on which I can test. There is a bit of a complication here in that it's hard to do this really correctly, we need an accurate description of the MIPS memory consistency model. My understanding is that that's currently more dependent on the individual chip vendor than some of us would like. I have some idea what it should be for old SGI machines, but I suspect that's no longer the primary concern here. I haven't checked on this in a while, so things may be better now. Hans -----Original Message----- From: gc-bounces at napali.hpl.hp.com [mailto:gc-bounces at napali.hpl.hp.com] On Behalf Of Christian Thalinger Sent: Monday, May 05, 2008 12:38 AM To: gc at napali.hpl.hp.com Subject: [Gc] mips support broken in gc-7.x Hi! I want to update to gc-7.x because of some additional functions which are very handy in a JVM. But it seems that MIPS support is broken: atomic_ops.c:74: error: parse error before "AO_locks" atomic_ops.c:75: error: `AO_TS_CLEAR' undeclared here (not in a function) atomic_ops.c:75: error: initializer element is not constant atomic_ops.c:75: error: (near initialization for `AO_locks[0]') Is MIPS not supported at all anymore or is this just a bug? - twisti _______________________________________________ Gc mailing list Gc at linux.hpl.hp.com https://www.hpl.hp.com/hosted/linux/mail-archives/gc/


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Social Media Strategies.
Social Networking with global organizations to develop effective strategies to reach out to new and existing audiences and build thriving social media communities.
Visualization of Content: This trend is obvious when you see the rapid rise of Pinterest and Instagram and the evolution of larger images on Facebook and Google+.
Mobile use and sharing: Powerful user experiences and business tools through creative use of mobile platforms and emerging technology.
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LinkedIn Profile set up: LinkedIn has over 85 million members in over 200 countries. Your professional network of trusted contacts gives you an advantage in your career, and is one of your most valuable assets. We set up your professional profile on LinkedIn and add new high quality business connections to get started with.
Customized YouTube Layouts: A professionally branded YouTube profile will set you apart from the hundreds of thousands of standard YouTube pages.
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Twitter Management: How much time do you have to manage your Twitter every day? Our Twitter management service is designed exclusively for businesses that need expert help in managing their Twitter.


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Apple Watch Sport 38mm Silver With Sport Band 2Y2
The Apple Watch Sport in 38mm has a aluminium case with a ceramic back in 33.3x38.6mm at a height of 10.5mm. It is splash proof though not water resistant. The 'movement' has a power reserve of 18 hours, after which it can be recharged using a magnetic charging cable. The glass on the Apple Watch version is sapphire.
Synced with an iPhone, it keeps time to within 50 milliseconds of the definitive global time standard. The 'dial' can of course be customized. It features various sensors to keep track of health and activity.Product Heightlights :
- Silver or space gray anodized aluminum case
- Ion-X glass
- Retina display with Force Touch
- Composite back
- Sport Band with stainless steel pin
- Digital Crown
- Heart rate sensor, accelerometer, and gyroscope
- Ambient light sensor
- Speaker and microphone
- Wi-Fi (802.11b/g/n 2.4GHz)
- Bluetooth 4.0
- Up to 18 hours of battery life
- Water resistant
- 1 x Apple Watch 38mm 2Y2
- 1 x Magnetic charging cable (2 m)
- 1 x USB power adapter (5W)
- 1 x Sport Band (includes band that can be configured for either S/M or M/L length)
- 1 x Quick start guide
We Also Recommend


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Celebrating Bank Street's First 100 Years
edited by Hal Melnick, '74, and Robie Harris, '70
The intent for this book is to convey in words and images the essence of our beloved institution and the very real ways we approach education for adults as well as for children from infancy through forever. Each chapter was designed to echo both John Dewey's and Lucy Sprague Mitchell's core ideas about learning as actively 'doing.' These ideas and principles are still in practice today at Bank Street for both children and adults. The verbs we chose for each chapter were intended to capture those principles and communicate how experiential learning is enacted today at Bank Street. By doing so, we hoped to convey the intentional interplay between theory and practice, which we believe all teachers and leaders must know and DO!
Each chapter has three sections as a way of showing the thread of history from 1916-2016:
Bank Street Then
—Bank Street's history, roots, and values
Bank Street Now
—Ways the School for Children and the Family Center foster teaching and learning
Graduate School Voices
—Voices of Graduate School faculty and alumni reflect how teaching and learning is enacted at the College today


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Operating Funds - Due to the seasonal nature of our business, our incoming revenue dwindles January through April, although we continue to provide job training services during this time. We request contributions to support our program in these reduced-income months. Your support will ensure that we do not have to cut back on any of our services during the winter months. Donors will be recognized on our website and in our newsletter.
Standard screw drivers and wrenches
Chain-type pipe wrench
Cordless power drills/ drill bit sets
- laminating sheets
- Plastic stack chairs for our multipurpose area
- Computer paper


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Discuss Instagram Marketing – Tutorial
Discuss Instagram Marketing
This tutorial has been designed to bring out the importance of this social media platform. Instagram can be used as a successful digital marketing tool for brand promotion. This tutorial provides details on how to effectively use this medium to make and share your stories digitally and reach the desired audience, resulting in higher sales and better user engagement.


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I have so much in my cart...I need to clean it out :)
My whole store will be on sale Monday and Tuesday the 4th and 5th of August. You will save a total of 28% off every item in my store. Some will be additionally discounted for even greater savings!
Here are some resources that have been very popular:
Melonheadz, Superhero, Owl Bulletin Board Sets
Now hop on over to Blog Hoppin' to find out who else is throwing a sale :)