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text:
Structural and functional studies of type three secretion virulence factors from gram-negative pathogenic bacteria
Metadata[+] Show full item record
Many pathogenic Gram-negative bacteria utilize type III secretion systems (TTSS) to alter the normal functions of target host epithelial cells. Of the 1.1 million deaths that are caused by Shigella each year, nearly a third are in children under five years of age. Salmonella enterica serovar Typhimurium is the leading cause of hospitalization and death due to food-borne gastroenteritis in the U.S. The pathogenesis of both of these species involves the invasion of epithelial cells of the gastrointestinal tract, which requires the use of a type III secretion system (TTSS). The Shigella type III secretion apparatus (TTSA) is composed of a basal body spanning both bacterial membranes and an exposed oligomeric needle. Host altering effectors are secreted through this energized conduit to promote bacterial invasion. The active needle-tip complex of S. flexneri is composed of a tip protein, IpaD, and two pore-forming translocators, IpaB and IpaC. Maturation of the needle-tip complex proceeds in a stepwise manner. IpaD is at the tip of the nascent TTSA needle where it controls the first step of TTS activation. The bile salt deoxycholate (DOC) binds to IpaD to induce recruitment of the first translocator, IpaB, into the maturing tip complex. The pore-forming translocators are bound by the class II chaperone, IpgC, within the bacterial cytoplasm in order to prevent premature association and degradation. Despite their importance in promoting Shigella virulence, few molecular level details are known regarding the interactions between IpgC and its targets, IpaB and IpaC. Additionally, the mechanism by which DOC serves to stabilize a conformational change within IpaD is poorly understood. Methods in structural biology, in particular X-ray crystallography, are extremely valuable in addressing such questions. We present here the crystal structures of IpgC (identifying an alternative quaternary state), DOC-bound IpaD and the N-terminal regions of both IpaB and SipB, the S. Typhimurium first translocator homolog. These structures have facilitated the functional analysis of crucial determinants of Gram-negative pathogens that would otherwise not have been possible. Additionally, these structural studies have revealed the critical α-helical nature of each protein subunit involved in mature needle-tip-translocon formation.
Table of Contents
Introduction -- Materials and methodology -- Evidence for alternative quaternary structure in a bacterial type III secretion system chaperone -- Identification of the bile salt binding site on Ipad from shigella flexneri and the influence of ligand binding on Ipad structure -- The crystal structures of coiled-coil domains from type three secretion system first translocator proteins reveal homology to pore-forming toxins -- Global discussion

subset: commoncrawl


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By Culturekiosque Staff
SAN FRANCISCO, 27 OCTOBER 2011 From today through Sunday 30 October, The San Francisco Fall Antiques Show, presents Treasures Tales a six-part lecture series. The theme of this years show, Hidden Treasures, is inspired by the pearl, the treasure hidden within an oyster shell that is the traditional 30th anniversary gift. The lecture series will explore a range of treasures with renowned experts in their fields, including: Archduke Dr. Géza von Habsburg, who will discuss princely treasures from Kunstkammern, and former FBI Agent Robert Wittman, who will share tales of art heists and masterpieces that remain hidden. Designer Saturday will focus on 30s movie set design and contemporary interior design. All lectures take place at the Festival Pavilion of Fort Mason Center.
Thursday, 27 October, 11:00 a.m.
Born to be Beautiful: Pearls and the Celebrated Women Who Wore Them
Ruth Peltason, Author, Editor, and Lecturer, New York
Like the finest strand of pearls, celebrated women are innately connected by the excellence of their jewelry. Diamonds may sparkle, and the jewelers trinity of rubies, sapphires, and emeralds may add color, but pearls are unique in gifting every woman with classic style. Society swans Grace Kelly, Babe Paley, Florence Gould, the Duchess of Windsor, Doris Duke, Chanel, Marjorie Merriweather Post, Barbara Hutton, Diana Vreeland, the Maharani of Baroda, and Elizabeth Taylor and their signature pearl necklaces, tiaras, rings, bracelets, and earrings made by the great jewelry houses will be showcased by Peltason, author of Living Jewels: Masterpieces from Nature: Coral, Pearls, Horn, Shell, Wood & Other Exotica (Vendome Press, 2010).
Book-signing to follow.
Presented in collaboration with the Museum of Craft and Folk Art.
Thursday, 27 October, 2:30 p.m.
Collecting Opportunities: The Rise of the Asian Art Markets
Henry Howard-SneydJoseph,, Vice Chairman of Asian Art, Sothebys, New York
In recent years, Asia has become a leading center of the international art market, with many newsworthy auctions of historic treasures and contemporary finds, such as the sales of the Meiyintang collection of Chinese ceramics and the Ullens collection of Chinese contemporary art. Howard-Sneyd, who has been the Sothebys auctioneer for many record prices in Asian art, will compare and contrast Chinese and Indian collecting and collectors. He also will analyze the boom and opportunities in the contemporary Asian paintings market.
Friday, 28 October, 11:00 a.m.
Princely Treasures
Archduke Dr. Géza von Habsburg, Fabergé Guest Curator at the Virginia
Museum of Fine Arts, Lecturer, and Author, New York
Book-signing to follow.
Presented in collaboration with the French Heritage Society, The Royal Oak Foundation, and Sir John Soanes Museum Foundation.
Friday, 28 October, 2:30 p.m.
U.S. vs. Art Thieves: Tales From the FBI's Real Indiana Jones
Robert Wittman, Former Special Agent and Founder of the Federal Bureau of Investigation's Art Crime Team, and Author, Pennsylvania
Dubbed as "the FBIs real Indiana Jones" and "the most famous art detective in the world," Wittman spent 20 years recovering more than $300 million of stolen art and cultural property. Sharing some of the tales in his bestseller, Priceless: How I Went Undercover to Rescue the World's Stolen Treasures (Crown, June, 2010), he will recount notorious heists and daring recoveries of priceless antiquities; paintings by Rembrandt, Monet, Picasso; and artifacts such as a rare Civil War battle flag. He also will report on attempts to find masterpieces that are still at large, such as the $500-million theft in 1990 from the Isabella Stewart Gardner Museum in Boston.
Book-signing reception to follow.
Supporting Sponsor: Waterworks
Presented in collaboration with The Northern California Chapter of the Institute of Classical Architecture & Art and the San Francisco Design Center.
Saturday, 29 October, 11:00 a.m.
Designing Hollywoods Golden Age: Art Direction from Films of the 1920s and 30s
Cathy Whitlock, Interior Designer and Author, Nashville
From the stylish, white-on-white, glossy interiors in Fred Astaire and Ginger Rogers musical classic Top Hat, to the dramatic Frank Lloyd Wright-inspired architecture featured in Ayn Rands The Fountainhead, Art Deco and Modernism reigned supreme during Hollywoods Golden Age of cinema. Using archival photographs and original renderings, Whitlock, author of Designs on Film: A Century of Hollywood Art Direction (Harper Collins, 2010), will illustrate memorable sets of the twenties and thirties and discuss the role of design in creating the transportive world of the "silver screen."
Book-signing to follow.
Presented in collaboration with the Art Deco Society of California.
Saturday, 29 October, 2:30 p.m.
Panel Discussion:
The Curated Home: Designing Today with Art and Antiques
Thomas Jayne, David Kleinberg, and Suzanne Lovell, Interior Designers and Authors;
Suzanne Tucker, Moderator
In honor of the shows 30th anniversary, celebrated interior designers will offer their trade secrets and professional advice on integrating fine and decorative arts with diverse architecture, textiles, finishes, and client sensibilities. These experts from across the country will share images and ideas from their new publications: Thomas Jayne on The Finest Rooms in America: 50 Influential Interiors from the 18th Century to the Present (The Monacelli Press, 2010), ranging from historic Monticello to contemporary Manhattan; Traditional Now: Interiors by David Kleinberg (The Monacelli Press, 2011), whose work updates the influence of his early career at the New York City firm of Parish-Hadley; Artistic Interiors: Designing with Fine Art Collections (Stewart, Tabori & Chang, 2011), showcasing Chicagoan Suzanne Lovells unique approach to designing custom environments; and insights from San Franciscos own tastemaker, Suzanne Tucker.
Book-signing reception to follow.
Preview Party: Wednesday, 26 October, 4:00 p.m. to 9:00 p.m.
Show: Thursday, 27 October Saturday, 29 October, 10:30 a.m. to 7:00 p.m.;
Sunday, 30 October, noon to 5:00 p.m.
Fort Mason Center, Festival Pavilion, Marina Boulevard at Buchanan Street, San Francisco, CA
For its 30th edition, The San Francisco Fall Antiques Show (SFFAS) features 65 leading decorative and fine arts galleries from across the United States and Europe, including new dealers Antoine Cheneviére Fine Arts from London, Galerie Lefebvre from Paris, and Spencer Marks from Massachusetts, along with returning exhibitors Beauvais Carpets and Kentshire from New York, Susan Ollemans Oriental Art from London, Steinitz from Paris, American Garage and Therien from Los Angeles, epoca and Hackett/Mill from San Francisco, and many others.
Benefiting Enterprise for High School Students, the West Coast fair features an mpressive range of fine and decorative arts, representing all styles and periods including American, English, Continental, and Asian furniture, silver, ceramics, glass, jewelry, rugs, textiles, paintings, prints, and photographs.
For more information, or to purchase tickets, please visit www.sffas.org.
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The Complete Media Inc. team is proud to announce the launch of Climate Systems Inc.'s new website! They have been a valued partner for many years, and we look forward to many more years of success with their new website.
Our team meticulously and thoughtfully moved their old content to an upgraded platform and expanded on their featured projects, services and other pages. With this modern and user-friendly design, Climate Systems clients and potential clients will be able to find information quickly and efficiently. The most valuable upgrade is that the site is now mobile friendly. We know that life gets busy, that's why it's imperative a website be mobile friendly for your viewing convenience. Click here to visit their new website and learn more about the products they trust, recent projects and a list of services.
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Exhibition Plus·Guided Tour
Sep 9, 2017 Saturday 14:30 - 15:00
Rockbund Art Museum (Shanghai 20 Huqiu Road, Huangpu District)
Tours are held at 2:30pm and are free for visitors with a valid ticket.
Guide: Vivian Li
Language: Chinese
To join: meet at the Museum Lobby on the Ground Floor.
Free admission, no need for reservation,but tickets should be purchased.


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Please explain briefly the doctrine of Total Depravity.
1. What it means and it does not mean.
2. Should the unbeliever know this doctrine? Why?
3. List of books that expound this doctrine.
Attempted answer:
1. Total Depravity (TD) is the biblical doctrine that relates to the sinfulness of man after the fall. When Adam and Eve sinned against God in Genesis 3, they became corrupt in their entire being and wholly incapable of doing anything truly good. This means that man became corrupt (not merely corruptible) in his thoughts, words and deeds. The Bible teaches this in many places. See Genesis 6:5 on man's heart and thoughts. See Proverbs 20:9 and Ecclesiastes 3:16-18 as well. The heart, according to Jeremiah, is "deceitfully wicked and desperately sick" (Jer. 17:9). Romans 3 is a very potent chapter on this subject as well. See verses 10-20 in particular. They make the point that no one does good, seeks God, understands, etc. 1 Corinthians 2:14 teaches us that the natural man cannot even understand the things of the Spirit of God. So to summarize, the Bible teaches that as a result of the fall (Adam's sin), all people are born corrupt. We sin against God. But sin is not simply what we do, it is now in the fabric of our being. Only God's grace can "reverse the curse."
The Westminster Confession has an entire chapter devoted to this doctrine. See chapter 6 "Of the fall of man, of sin, and of the punishment thereof." I will quote it at length:
1. Our first parents, being seduced by the subtlety and temptation of Satan, sinned, in eating the forbidden fruit. This their sin, God was pleased, according to his wise and holy counsel, to permit, having purposed to order it to his own glory.
2. By this sin they fell from their original righteousness and communion with God, and so became dead in sin, and wholly defiled in all the parts and faculties of soul and body.
3. They being the root of all mankind, the guilt of this sin was imputed; and the same death in sin, and corrupted nature, conveyed to all their posterity descending from them by ordinary generation.
4. From this original corruption, whereby we are utterly indisposed, disabled, and made opposite to all good, and wholly inclined to all evil, do proceed all actual transgressions.
5. This corruption of nature, during this life, doth remain in those that are regenerated; and although it be, through Christ, pardoned, and mortified; yet both itself, and all the motions thereof, are truly and properly sin.
6. Every sin, both original and actual, being a transgression of the righteous law of God, and contrary thereunto, doth, in its own nature, bring guilt upon the sinner, whereby he is bound over to the wrath of God, and curse of the law, and so made subject to death, with all miseries spiritual, temporal, and eternal.
The doctrine of Total Depravity should be distinguished from utter depravity which would suggest that man is as bad as he could be. People often confuse the two ideas. TD teaches that man is corrupt in all his parts, but allows that God's restraining grace keeps man from becoming as bad as he could be.
2. I would suggest that the unbeliever needs to hear the law and the gospel. I'm not convinced that a complicated explanation of TD is helpful for an unbeliever. However, there are numerous ways in which it could be suggested that glimpses of the doctrine are given to unbelievers in the New Testament, sufficient to show them their depravity and hopelessness apart from Christ. John Murray, a respected theologian, is remembered for saying "grace without law is meaningless, and law without grace is pointless." The point is, unbelievers need to understand that "all have sinned and fall short of the glory of God" (Rom. 3:23) and that "The wages of sin is death, but the gift of God is eternal life through Christ Jesus our Lord" (Rom. 6:33). The gospel is like a lovely diamond; and diamonds are most visible against a dark piece of cloth. In this illustration, the law is the dark piece of cloth. It exposes our sin, and causes Christ's gospel to shine all the more.
3. Let me suggest a few books at a popular level: Putting the Amazing Back into Grace by Michael Horton, The 5 Points of Calvinism by Steele and Thomas, The Bondage of the Will by Martin Luther. For more technical treatments, you can consult nearly all reformed systematics like John Calvin's Institutes, and Hodge's and Berkhof's systematic theologies.
You are wrestling with a difficult but important topic. Take your time. Pray your way through. Please let me know if you have any follow up questions.
"Questions and Answers" is a weekly feature of the OPC website. The answers come from individual ministers in the Orthodox Presbyterian Church expressing their own convictions and do not necessarily represent an "official" position of the Church, especially in areas where the Standards of the Church (the Scriptures and the Westminster Confession of Faith and Catechisms) are silent.
The questions come from individuals like yourself. If you have questions about biblical and theological matters, you are invited to send them by e-mail by using the "Pose a Question" link on the OPC home page or by clicking here.
At least one new question is posted each week, so there should always be something new here for you to read. (For those people who would like to look at previous questions and answers, they will continue to be available as well.)
The purpose of the OPC website's "Questions and Answers" is to respond to biblical and theological questions. Matters of church discipline, disputes, or debates go beyond the scope of our work. We recommend that you present your concerns in these areas to the appropriate judicatory. In most cases this will be to a local pastor, elder, or session. We do not want the website to replace personal involvement in, or commitment to, the local, visible church.
While we will respond to every serious questioner, we are not bound to give a substantive answer to every question, should we deem the question to be beyond the scope of our purpose or our own ability to answer.
You will receive an answer by e-mail. Please be patient as many of our respondents are busy pastors. The response to your question may take up to two (2) weeks. Some of the questions submitted will be chosen to be posted here, along with the corresponding answers.
Note that the "Questions and Answers" posted on the site have been editedall personal references are removed, Scripture references or from some source may be added, and sometimes portions are expandedto make the questions and answers more useful to a larger audience.
|© 2020 The Orthodox Presbyterian Church
Chaplains and Military Personnel


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Everything must be perfect.
We want the perfect date and the perfect partner. We want an exemplary family life, a sequence of once-in-a-lifetime moments experienced with a perfect soundtrack and flattering lighting. A life that photographs well through the right Instagram filter, blurring the inconsequential and highlighting what's important, because what's the point of having a perfect life if no one is there to witness it or affirm it by clicking "like". And what is life if not the content we generate and broadcast to the world, measured by popularity on individual networks that connect us all.
Man, woman, infant, matching furnishings, complementary luxury fixtures and an internal swimming pool. These are the elements comprising the world image created by Elisheva Levy in the gallery space. Neatly listed, they read like an index for the good life, detailing the ingredients to a recipe common to all consumers of late capitalism, a formula for success meant to work for everyone if only they follow the strict instructions. Employing this formula, Levy produces objects and environments that seem perfect at first glance, but are revealed to be empty, brittle and fragile husks of unrealized experiences.
Among the objects she positions in the gallery are many that are everyday items that still manage to be extravagant in various ways, the most prominent of which the internal swimming pool. Private pools are clear status symbols, an amenity testifying to an elite lifestyle, leisure time and over-privilege. An indulgent and desired life. A pool is a demarcated and tame model of the sea, marking the boundaries and subjugating for our watery pleasure the ocean blue and the azure skies. It is presented with the pale navy edging and right lighting. A private slice of artificial sky, a personal heaven that can be dived into. A promise of the moment when the consumerist illusion is wonderfully fulfilled while aglow in hyper-natural colors.
But something has gone wrong in the clichéd beauty and glamour. The relaxed scene of luxury dazzles us with refracting rays of light of water ripples that flicker on the walls with a spectacular sapphire performance. But the exquisite image created by Levy leaves an aftertaste the moment you realize it is a pool made of paper, its rims of paper reams and aluminum foil – clearly cheap materials pasted together, with the image of water projected on their surface. The sound of the water is a soundtrack heard from loudspeakers located on the ceiling.
The use of cheap materials is not the only disruption to the illusion. Added to this is the chaotic image produced by the placement of objects in the space. The objects are all there, but in the wrong order. The extravagant lifestyle is presented to us in tatters, fragments uprooted from their original context.
On the lip of the pool stands a large and lanky figure of a man of enormous proportions. He stares at the glittering water, the only source of light in the room. He gives the impression of a peculiar Narcissus figure facing his reflection, or a warped reference to Venus rising from the waves. He seems at once lonely, dejected and threatening. His quietude is unnerving. His blank stare unseeingly gazes at the baby wading the water in the float. The male figure is pathetic, vulnerable and emasculated. His entire aspect is one of humiliation so palpable it demands some form of compensation that would allow for a recovery of lost manliness (because a "real man" can defend himself and his place, can demand restitution).
In the smaller of the gallery spaces are additional objects: a shag carpet, a standing lamp, a broom, several items of clothing and others. All made of paper. The dominant color is an excessively vibrant pink, the stereotypical tone of soft femininity. The products and items scattered about, all uniformly color coordinated, a kind of nouveau riche furniture set, serve as another illustration of the showcase consumer culture and elite class.
A pair of feet peep out from the carpet – the figure of a woman reclining on her stomach, strewn among the furry pink shag that bunches around her. Beside her is a roll of (predictably) heart-patterned toilet paper.
Human figures have only recently begun to appear in Levy's work, and their presence expands her path of exploration into living environments and their impact on our lives. Just like the products and environments that appeared previously in the artist's work, these too are hollow paper creations. The method of manipulation remains, indicative of the understanding that narcissism and brand culture are intertwined, and that our need to be surrounded with the right brands stems from the hollowness within us – puppets operating singly due to the authority of norms determined for us. We appear and feel authentic and human, but actually function within the narrow confines dictated by powers greater than ourselves.
We rely on self-help books, personal coachers, and a healthy dose of positive psychology to relentlessly practice a proactive approach to life, preferring this to introspection, focusing on problems, and a profound look at our pasts. We must always focus ahead, be optimistic, and maximize anything and everything for personal gain.
Margaret Thatcher's remark from 1987 has never been truer – "There is no such thing as society".
The market isn't free, and doesn't serve our interests. It is we who are in its service. We are privatized units that upload our lives on the stage of the world, all actors with our cues to enter and exit aimed only at preserving a system of accumulating capital.
In an age in which it is not the product that counts, but the right brand (and when brands have managed to produce distinct personalities), we are incentivized to rely on brands to construct our own personal brands. We have become consumer products in our own right, and as such are required to become brands for other consumers, who are just as empty. As brands, we need to emphasize our assets and present as cultured, intelligent, sophisticated and stylish. In our heart of hearts, we know it is an act, but we still want to believe it. In fact, we are coerced into believing, as our lives depend on it, and any discrepancy between appearance and essence, any exposure of the empty spaces, becomes an unbearable threat.
So what happens when we are not part of the privileged? What happens when we are prevented our rights to appear the way we want to appear? When our rights, entitlement and self-worth are denied us, as they are entirely reliant on our social status and the opinion of others?
Any threat to our sense of entitlement to the golden life may bring about catastrophic outcomes, to aggressiveness, to violent outbursts.
The more we empty ourselves, the more others are drained, but without the hollow woman, the hollow man is silenced. Dependence and violence are entangled. We cannot exist without the affirming gaze of others, but they too have no purpose beyond filling the transmissible empty spaces.
Tangible life closes in on us from every angle, but the life represented to us in the inundating flood of images seem so easy and effortless, so possible. The entitled worldview promises this life is just within our grasp if only we reach out and grab hold of it.
The other exists to validate us with his gaze, but that is the sum total of his role. Harming others while on the path to self-fulfillment is not only acceptable – it is as transparently viable as the nonexistent pool waters in in Levy's work, which makes us love all that blinds us even more – and thus reveals the darkness and gaping spaces within us.


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The Ontario-Jiangsu Industrial Research and Development Program (OJIRDP) supports joint industrial R&D projects focusing on the development of products or processes that will lead to commercialization in global markets. A partnership of the Jiangsu Science and Technology Department (JSTD) and the Ontario Ministry of Economic Development, Job Creation and Trade (MEDJCT), OJIRDP supports projects leading to commercial success and socio-economic benefits for both jurisdictions.
Successful Ontario applicants may receive a maximum of $150,000 CAD per project ($125,000 CAD direct costs and $25,000 CAD indirect cost for academic applicants and $150,000 CAD direct costs for company applicants) from OCE under the OJIRDP program, to fund the Ontario portion of the project.
OCE anticipates that four projects will be funded through the 2018 Call for Proposals.
Ontario and Jiangsu will conduct parallel application processes. Ontario-based applicants must apply directly to Ontario Centres of Excellence (OCE). Jiangsu-based applicants must apply directly to Jiangsu Science and Technology Department (JSTD).
Project terms must be between one and three years and are non-renewable.
OCE will support up to 50 per cent of the total eligible direct research costs, to a maximum of $125,000 CAD per project (for academic applicants) or $150,000 CAD per project (for company applicants) for the Ontario portion of the project. JSTD will support up to 50 per cent of the total eligible direct research costs, to a maximum of ¥1 million RMB per project, for the Jiangsu portion of the project.
Contributions by OCE and JSTD must be matched at least 1:1 in cash and/or in-kind by applicants/partners in Ontario and Jiangsu, respectively; i.e. to receive the maximum grant amount, the Ontario applicant/partner(s) must provide at least $125,000 CAD (for academic applicants) or $150,000 CAD (for company applicants) in cash and/or in-kind, and the Jiangsu applicant and/or partner(s) must also provide at least ¥1 million RMB in cash and/or in cash and/or in-kind. Letters of support from each organization providing cash and/or in-kind contributions must be included along with the application, confirming both the amount of matching funding and the intended use of the contributions.
Academic applicant: $125,000 CAD cash and/or in-kind
Academic applicant only: $25,000 CAD
Matching contributions can consist of both cash and in-kind contributions from any non-government source. Cash contributions are funds from contributing partner(s) paid to and expended by the lead applicant. In-kind contributions are non-cash resources or expenses incurred by partner(s) for direct purpose of the project, and are to be listed as part of a project's overall budget. All cash and in-kind contributions must also comply with criteria listed in the Eligible Expenses Guidelines. Applicants must be able to verify the value of in-kind contributions with independent, third-party valuations.
In-kind contributions must:
In-kind contributions can include:
Ineligible in-kind contributions include:
For more information on eligible and ineligible expenses please refer to the OJIRDP Eligible Expenses Guidelines.
Funding is open on a competitive basis. Lead applicants should be:
In Ontario: An R&D performing company incorporated in Ontario or a publicly-funded post-secondary institution (university, college or research hospital) accredited in Ontario. Post-secondary institutions are strongly encouraged to have contributing industry partners, and vice versa companies may have post-secondary institutions as contributing partners if applicable.
In Jiangsu: An R&D-performing Jiangsu-registered company operating in Jiangsu. Academic/research entities are eligible to participate in the project as sub-contractors only.
OJRDIP is a discretionary, non-entitlement program with limited funding. All eligible projects are assessed on their merit and undergo a review process against program objectives and other criteria.
Applicants must first submit Expression of Interest (EOI) to both OCE and JSTD, which will be evaluated for eligibility and alignment of the project with program criteria and objectives. The same EOI must be submitted to OCE and JSTD, including the same applicant's/partner(s)' names and project title. The top-ranking EOIs will be invited to submit a full application to the program.
Full applications will be assessed in a three-step process:
Applications will be evaluated on several criteria, which include but are not limited to:
Ontario Ministry of Economic Development, Job Creation and Trade (MEDJCT) and JSTD reserve the right to select project proposals that are mutually agreed upon. The final decision will be communicated through email to the Lead Applicant(s) identified in the application.
If selected to receive a grant under OJIRDP, Ontario applicants, and partner(s) if applicable, must enter into an agreement with OCE within 60 days of receipt of notification letter.
A sample of the OCE Funding Agreement can be downloaded for your reference. Please do not fill out this form; a copy of the agreement will be generated through our online management system and sent to you upon approval of your project. The letter of intent ("LOI") signed by all applicants and partners (including Ontario and Jiangsu applicants and partners) detailing intellectual property rights and commercialization strategy for the product or process submitted with the full application will be incorporated as Schedule D (Intellectual Property Term Sheet) in the OCE Funding Agreement to be executed by OCE and the Applicant if the project is funded. The signed OCE funding agreement and fully signed IP Sharing Agreement or Collaborative Research Agreement agreed upon by all parties (applicant, institution and Project Contributor(s) (industry partner(s), including Jiangsu applicant and partners) must be submitted prior to project activation. Please note disbursement of OCE funds is also conditional upon execution of an agreement between JSTD and the Jiangsu applicant.
The applicant must contact the Program Manager as soon as possible at time of occurrence for any material change in the project, including but not limited to: changes related to the project's principal investigator, the industry partner, scope of work or eligible costs.
For any variances to the OCE budget of $5,000 or greater, or extensions to the project end date, the applicant must complete a Project Change Request form prior to the project end date, using the Project Administration tab in their AccessOCE project file. If an extension to complete the project is required, the Applicant must request it prior to the scheduled project completion date, using the Project Administration tab in their AccessOCE project file. A maximum extension of six months will be allowable.
The following project reports will be required:
Please Note: Applicant must retain all proof of purchases, receipts, and other relevant documentation relating to eligible expenses for the project duration in accordance with applicable Canada Revenue Agency or research requirements.
All required final reports by applicants and partners must be submitted within 30 days of project completion in order for release of the holdback, and to maintain good financial standing with OCE. Release of OCE holdback will also be contingent on JSTD confirming successful completion of the Jiangsu component of the project.
Launch of call for Expressions of Interest (EOI)
September 27, 2018
Expression of Interest (EOI) Submission Deadline to OCE for Ontario applicant and to JSTD for Jiangsu applicant
November 13, 2018 (2pm ET for Ontario applicants)
Invitation for full application
Early 2019
Full Application submission deadline to OCE for Ontario applicant and to JSTD for Jiangsu applicant
Notification of results
May 2019
For a project to be considered for funding under OJIRDP, the lead Ontario applicant must apply directly to OCE, and the Jiangsu applicant must apply directly to JSTD. The same proposal must be submitted to OCE and JSTD, including the same applicant's/partner(s)' names and project title. Funding is conditional on both applicants receiving funding approval from their respective organizations. Please read all instructions available in the Download section below to ensure your application is completed correctly. EOIs or applications that are not completed correctly may result in rejection.
Applicants needing additional information or clarification regarding the Ontario- Jiangsu 2018 Call for Proposals may contact:
Angela Fong
Program Manager
Ontario Centres of Excellence
T: 416.861.1092 x 9-1071
E-mail: firstname.lastname@example.com
Li Liu
Technical Manager
Jiangsu Center of International Technology Transfer
Jiangsu S&T Exchange Center with Foreign Countries
E-mail: email@example.com
Ren Xiaohui
Program Coordinator
Jiangsu Science and Technology Department (JSTD)
E-mail: email@example.com


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Indication for Use: RUBY-FILL® is a closed system used to produce rubidium (Rb-82) chloride injection
for intravenous use. Rubidium (Rb-82) chloride
injection is a radioactive diagnostic agent indicated for Positron Emission Tomography (PET) imaging of the
myocardium under rest or pharmacologic stress conditions to evaluate regional myocardial perfusion in adult
patients with suspected or existing coronary artery disease.
New Important Safety Information April 2019
Please note changes in Boxed Warning, Dosage and Administration, Directions for Eluting Rubidium
Rb 82 Chloride Injection (2.5), Contraindications (4), Warnings and Precautions, High Level Radiation
Exposure with Use of Incorrect Eluent (5.1).
The risk information provided here is not comprehensive.
Please visit RUBY-FILL.com for full Prescribing Information including BOXED WARNING.
You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/MedWatch or call 1-800-FDA-1088.
References: 1. RUBY-FILL® [package insert]. Kirkland, Quebec, Canada: Jubilant DraxImage Inc; April 2019. 2.
Renaud JM, Wiles M, Garrard L, Beanlands RSB, deKemp A. New rubidium-82 generator efficiency improves over time. J Nucl Med. 2018;59
(suppl 1):1045. 3. Lewin HC, Millard A. Dose accuracy of 82Rb generator systems. Paper presented at: SNMMI Mid-Winter Meeting;
January 17–19, 2019; Palm Springs, CA.


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Why I'm an Airline Travel Specialist
I take pride in arranging what is usually the least pleasant part of a trip, the air travel, and making it as painless as possible. If I do my job well, the clients don't remember the plane rides.
Destinations Visited
Namibia, Botswana, Zambia, South Africa, Malawi, Bermuda, United Arab Emirates
Airline Travel and Stopover Hotels
BS in Aviation Management, Salem International University (formerly Salem-Teikyo University)
Career History
Customer Service Lead, US Airways.
Adventure Travel Consultant, Wayland Travel / ATD.
Charter Flight Coordinator, Caesar's Entertainment.
Most Recent Trip
My most recent trip was to Dubai, UAE. I stayed in amazing hotels, and went to the top of Burj Khalifa, which is currently the world's tallest building! This stood in stark contrast to the old part of the city (al Fahidi district), and the gold and spice souks. I also got to experience a desert safari, which included a hectic drive over the dunes, a falconry demonstration, and a lovely dinner under the stars complete with music and belly dancing.
Recommended Travel Experience/Destination Right Now
As the air guy, I'm going to put my own twist on this. Wherever you go, be sure to have someone knowledgeable planning the airfare. A professional will help you balance all the factors, including comfort, cost, route, and price.
Favorite Airlines
Emirates offers fantastic business class fares on a pretty consistent basis, and complimentary chauffeur service to their business class customers. They also offer complimentary hotels for forced stopovers in Dubai.
Delta flies just about EVERYWHERE, and even the economy seats are pretty comfortable.
Great fares for domestic flights and bags fly free!
South African Airways
Often the best fares to Africa, and great US customer service department.
Air New Zealand
Just because I love the "skycouch" concept.


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Russell County Fiscal Court
Russell County Fiscal Court is located at 410 Monument Square, Suite 205 Jamestown, KY 42629.
Fiscal Court Meetings
2nd Monday at 6:00 PM
Magistrate District #1: Terry Waddell (R)
Cell: 270-566-1077
Magistrate District #2: Patrick Loy (R)
Cell: 270-566-0756
Magistrate District #3: Ronald Johnson (R)
Cell: 270-566-1887
Magistrate District #4: Steve Richardson (R)
Cell: 270-866-0716
Magistrate District #5: Larry Holt (R)
Cell: 270-585-2002
City of Jamestown
Jamestown, the county seat of Russell County. The town first called Jacksonville, in honor of President Andrew Jackson, was incorporated on December 23, 1827. When the local Anti-Jacksonian Party came into power in 1826, the community was renamed Jamestown to honor James Wooldridge, donor of the one hundred acre town site.
Lake Cumberland, completed by the Army Corps of Engineers in 1952, is of great economic importance to Jamestown for the recreational fishing and boating along its 1,317 miles of shoreline in the region. Wolf Creek Dam is located in Russell County on Lake Cumberland. Wolf Creek Dam, located in Russell County forming Lake Cumberland, was not only built by the U.S. Army Corps of Engineers (USACE), but is also owned and operated by them.
Jamestown considers itself a family oriented community;voted #1 in Kentucky best small town for raising a family, 19th in the nation, family values, friendly people, low crime rate, strong work ethic, and involved leadership.
City of Jamestown is located at 112 North Main Street Jamestown, KY. 42629
Phone : (270) 343-4594
Office Hours : Monday-Friday 8:00 am to 4:00 pm
City of Russell Springs
City of Russell Springs City Hall is located at 72 High St, Russell Springs, KY 42642. You can also contact Eric Selby at 270-866-3496.
Russell Springs is a 4th-class city in Russell County, Kentucky. The city is known as the gateway to Lake Cumberland , one of the largest man-made lakes east of the Mississippi River, created by the impoundment of the Cumberland River by Wolf Creek Dam . Russell Springs is the largest city in the county, having a population of 2,452 during the year 2012 U.S. Census. Russell County sits at the start of the Central Time Zone line, so all areas of Russell County reside in the Central Time Zone.
The present city grew out of a resort centered on a local chalybeate spring.
The local US Post Office was established in 1855 as "Russell Springs", named after the county, but was discontinued in 1865 and reopened as Kimble (after local businessman George Kimble) in 1888. The community restored the name Russell Springs in 1901 and incorporated in 1936. The county and the city are named after Col. William Russell, a local veteran, politician and businessman of the time.
Russell Springs is located geographically in the southern portion of the state of Kentucky and roughly halfway from east to west between its borders.


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E. Takashi Norris
Takashi Norris (Tak) has been the founder and President of PLATINUM since its incorporation. He has been involved in commercial and residential real estate leasing/buying/management, in addition to real estate investments in the last 12 years in Tokyo. In 2007/8, Tak was successful in putting together over 4 Billion JPY worth of property transactions. In addition to working with onshore clients and investors, Tak has also advised and completed acquisitions of properties in Japan for overseas investors in the United States, Europe and Asia. Prior to setting up PLATINUM, Tak worked with the American Chamber of Commerce in Japan, serving as a liaison for executives of both Japanese and foreign multinationals, brokering business deals for both the private and public sectors.
Tak is bicultural and bilingual and is a native of New York City, graduating from The Dalton School with a B.A. in International Relations from Colgate University. Tak is married with two children and interests are reading, bicycling, fishing and martial arts.
Managing Director
Hideaki Fukushima
Hideaki Fukushima joined PLATINUM in 2003. He is the registered real-estate transaction manager and is involved in every real estate contract at PLATINUM Hideaki brings 18 years of experience in the real estate business and mainly handles purchase and sales, development, research, and appraisal.
Hideaki is a native of Aomori prefecture and received his bachelors in Tokai University where he has also received a black belt in Taido a type of martial arts.
Kevyn Johnson
Kevyn Johnson specializes in commercial relocation projects at PLATINUM for international firms and retail businesses leasing or purchasing space in Central Tokyo. Prior to his 2007 move to PLATINUM Kevyn spent four years in SME office design and fit-out and is co-chair of the Architecture, Construction and Real Estate (ACRE) committee for the American Chamber of Commerce in Japan (ACCJ).
An 18 year veteran of Tokyo, bilingual and bicultural, Kevyn has also written two handbooks on English language use, and continues to write in his spare time.
Murray Gilbert
Murray Gilbert is the Senior Analyst of the team. He is responsible for developing financial models and comparing property investment scenarios. Previously, Mr. Gilbert has served in various financial and service firms in Tokyo including Capital Servicing - a real estate advisory and investment firm as well as ValueCommerce, and General Electric where he was responsible for building and supporting financial models and IT systems.
A Japanese/English bilingual Murray has been living and working in Japan for over 10 years. Prior to coming to Japan, he worked for an Australian software house with local and international clients. He completed his Bachelor of Science in computer science at Macquarie University.
Contact Us
Copyright © 2020. All rights reserved


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SpongeBob Christmas Stop-Motion
SpongeBob will star in his first full-length stop-motion animated special 'It's A SpongeBob Christmas!', this holiday season. Inspired by the classic Rankin/Bass ('Rudolph the Red-Nosed Reindeer' & 'Santa Claus is Comin' to Town') TV specials, and the popular SpongeBob song released in 2009, 'Don't Be a Jerk, It's Christmas,' written by Tom Kenny (voice of SpongeBob) and Andy Paley, the new show is animated by the talented team at L.A.'s Screen Novelties studio. Screen Novelties have animated sequences for 'SpongeBob', 'Chowder' and 'Marvellous Misadventures Of Flapjack', but this is their first full-length episode. Watch a Screen Novelties Showreel posted on the Animated Review and the 'SpongeBob' trailer posted below.
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Product Details
- Fits
- Any 510 threaded eCig Battery
- Liquid Per Clearomizer
- 5 ml
- Puffs per full Clearomizer
- 1200
- Ratio
- 1 Full Tank = 88 Tobacco Cigarettes
- Material
- Stainless & Pyrex Glass
- Weight
- 74 g
Customers who bought the Nautilus BVC Clearomizer Set (clone) also bought...
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Recently bought Nautilus BVC Clearomizer Set from this store. Their prices are great, and the customer service is reward-able. The products they offer are authentic, or otherwise stated so. The shipping is fast and affordable. I have and will recommend unlimitedecigs to all my friends and anyone else who is interested in vaping.
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This Day in History – November 28th, 1893
New Zealand women gained the right to vote with the passage of a bill by the Legislative Council on November 28th 1893. The House of Representatives (then the elected lower house) had passed such a bill several times previously, but for the first time in 1893 the appointed Legislative Council did not block it.
The growth of women's suffrage in New Zealand largely resulted from the broad political movement led by Kate Sheppard, the country's most famous suffragette. Inside parliament, politicians such as John Hall, Robert Stout, Julius Vogel, William Fox, and John Ballance supported the movement. When Ballance became Premier in 1891 and established/consolidated the Liberal Party, many believed that female suffrage would ensue imminently, but attempts to pass a suffrage bill repeatedly met with blocks in the Legislative Council, which Ballance's outgoing predecessor, Harry Atkinson, had stacked with conservative politicians.
When Ballance suddenly died in office on April 27th 1893, Richard Seddon replaced him as Premier. Seddon, though a member of Ballance's Liberal Party, opposed women's suffrage, and expected it to be again blocked in the upper house. Despite Seddon's opposition, Members of Parliament assembled sufficient strength in the House of Representatives to pass the bill. When it arrived in the Legislative Council, two previously hostile members, moved to anger at Seddon's "underhand" behaviour in getting one member to change his vote, voted in favour of the bill. Hence the bill was passed by 20 to 18, and with the Royal Assent it was signed into law on September 19th, 1893. In the 1893 general election women voted for the first time, although they were not eligible to stand as candidates until 1919.
It is often said by this measure New Zealand became the first country in the world to have granted women's suffrage.


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After weeks of being holed up in our work/home, our ever spontaneous friend decided for a relaxing Bantayan trip! Took a 4 hours bus ride from Cebu North Terminal to Hagnaya Port, and an hour to Sta Fe, Bantayan.
We checked in to Hoyohoy Villas and the place was perfectly chill! Never been to a resort like this before. Aside from the quiet resort, the season was perfect for a relaxed atmosphere – few tourists, sunny weather, endless sea breeze – it felt that the resort belonged to us. The beach area in our resort was quite shallow, so it wasn't really ideal for snorkeling; walked quite far from the shore and it was only knee-deep! So we settled with just lying down by the shallow crystal-clear waters, under the warm sun, fanned by the gentle and cool sea breeze. We spent most of our time in their outdoor beds enjoying the breeze and thinking of nothing.
Hoyohoy Villas, as it name implies are just made up of a few villas and some basic rooms, so even if in full capacity, I believe the place won't be so crowded. So this resort is made for relaxing and a quiet atmosphere.
Sta Fe is a haven for tourists, looking to relax and dine. The locals are really friendly, there will be some constant offers of island hopping but we were into laid-back beach vacation. Our main mode of transport was with a tricycle which costs 20 Php per head. We rented a bike for 150 Php a day, toured around a bit and posed for some touristy photos. They have an authentic Italian restaurant which we enjoyed for dinner. They also have an authentic French bakery, a perfect breakfast for a relaxed island holiday.
Overall, the experience was amazing. I was told that during Holy Week, the place gets too crowded that the town never sleeps. We were lucky that the it wasn't peak season, and the perfectly destressing atmosphere we were looking for was right there at the moment.


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{renovate} shang-hai ... revisited
Friends. Remember last year when my husband came home from a swap meet with the biggest-sign-ever-made and it sat in our backyard from MONTHS (read more about that here)?
And remember when I gave that sign a fighting chance and we tried to hang it on the ONE wall on our ENTIRE property that it fit? But it didn't actually fit, it was just completely overwhelming (read more about that here)?
Yeah, we sold that sign. But I'm back for part two of the story. You didn't know there would be a part two, did you? Yeah. I didn't either. But, my husband went to the same swap meet this year and once again, came home with a sign. I should've seen it coming :).
We're now the proud owners of this sign:
Which, I have to admit is not only MUCH smaller .... but much better. It's quirky and fun and actually pretty rare. We're not sure if we're going to keep it, or if we do keep it for how long. But, I'm leaning towards enjoying it for the summer. I like the owl :). I'll let you guys know where it ends up finding a home.
So tell me guys ... what does your husband/wife/partner/s.o. regularly "surprise" you with? Is there someplace they go and always ending coming home with something?? :)
4 comments:
cute sign! I'm the one who always comes home with junk that we have no where to put. My husband just looks at me and shakes his head. But it always seems to work out--I've gotten some pretty cool stuff over the years. So I think he trusts me now;) Can't wait to see where you put your new sign!ReplyDelete
I can totally see that sign hanging up in your house somewhere.ReplyDelete
I didn't know about your blog during the shanghai phase but I'm sad to hear it didn't work! The little Wise owl is such a perfect replacement though!ReplyDelete
Wow, the shanghai sign was huge. I can see why you couldn't find a place for it. The wise potato chip sign is really cute and fun, I know you'll have success placing this one :).ReplyDelete
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Please note this establishment is now closed.
I really really like the concept of Nourish. I really really like the guy behind it. There is a but, but (not that one) you'll have to wait for it.
Nourish started life in Sheffield in 2013 and has since moved to the better side of Yorkshire (wink wink) with it's first place opening in Leeds a couple of months ago. Dave Stache runs the joint, he's a nutritionist by profession but is passionate about the food market and getting good food in to the mouths of the people of Yorkshire.
There's so much thought and effort going in to the meals, with local suppliers on hand where possible and ethically sourced ingredients. The meals themselves are packed with the most nutrients possible and (as quoted by Nourish) "no calorie is wasted".
There are a lot of places opening in Leeds that are focusing on lad food, overindulgence and general American overloaded junk food. To see a healthy based option open in Leeds was quite novel.
I was invited along, with many other bloggers and media types to hear and try first hand what Dave has to offer us, the people of Leeds.
Smoothies: There are a range of smoothies available, the one below was a high protein low carb smoothie with spinach... it wasn't for me. The one I didn't take a picture of (typically) was for me and that was the bulletproof mocha containing almond milk.
We tried small samples of a few of the dishes which I will outline below:
|Thai Red Chicken Curry
|Superfood salads
|Moroccan Chicken Curry
|Salmon Superfood Salad
|Chicken Satay
It was nice to be able to taste a range of the menu rather than just one dish, however there was a feeling that was echoed by others who I spoke with... it was all just a bit bland. I even saw one person shovelling salt in to her dishes to add a bit more flavour.
Not wanting to give up on them on the first go, as mentioned I really liked their ethos and drive, I went back for lunch.
I opted for the turkey meatballs, a true test of their abilities because (not one to often blow my own trumpet but on this occasion there is reason to) I make the best turkey meatballs out there.
They were bland. So bland that the meat almost tasted of plastic. The sauce had not marinated inside the meatball and when bitten in to they were completely white, the sauce was just on the outside, and it was dry inside and out.
I've spoken to non-bloggers who have tried out nourish and their sentiments have been echoed. I have a work colleague who is lactose intolerant and a vegetarian (and probably something else too) who struggles to find places to cater for his needs, Nourish seemed perfect as it had a few dishes he could order... he too echoed my sentiments that the food was just too bland.
I feel bad for writing this review and I have pondered over publishing it for the last couple of months. I'm still battling the reasons for publishing it now... But I guess someone must like them as they're still open and surely my little blog won't make too much of an impact...


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Website last updated October 18th, 2020.
Casey & her friend Sunshine arrived at VPAS in April of 2012 because their owners had to move & were unable to take them along. At that time Casey was obese & needed to lose weight. She did very well on her diet, but after she began to lose some weight we discovered that the extra fat on her body was hiding several mammary tumors. The tumors would have taken Casey's life so we opted to try surgery to see if they could be removed. Sadly, once she was in surgery we discovered that she had many mammary tumors & her chances for survival were not good. We had to make the difficult decision to euthanize her so that she would not suffer as her tumors began to grow & take over her body. Although Casey wasn't with us very long we will miss her, as will her friend Sunshine.


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Sabah al-Mukhtara discusses the reduction of US combat troops and the effects it will have on ordinary Iraqi people.
US and Iraqi politicians have held ceremonies to mark the end of US "combat operations" in the country and the reduction of American troops to less than 50,000.
The United States has branded its new phase of deployment in Iraq as "Operation New Dawn", ending "Operation Iraqi
Sabah Al-Mukhtar, an Iraqi political analyst, told Al Jazeera that the ceremonies could only be viewed negatively by ordinary Iraqis:
"It is a very painful day for the Iraqi people to watch the Iraqi withdrawal celebrations, which began by telling them that the occupier is celebrating in the palace of their president or, be it, he was a dictator; and ending it with the God save America song, as well as the Christian prayer.
"This is not a very happy day for the Iraqis, at the end of the day, the Iraqi people have suffered. So many people died, the country is destroyed.
"The Americans are talking about how they are feeling sorry for the 4,000 soldiers who were killed in a battle that they have started and nobody asked them for. They are now talking about building Iraq in the next seven month, as if the seven years that has passed achieved anything.
"So we are told in the next seven month they will achieve their miracles and if we listen to all their speeches about their education initiatives and suddenly the generals and all the politicians have remembered all the history of Iraq as if they have just brought it into life. So it is a really disturbing way of looking at it from outside the US.
"The Iraqi politicians are extremely concerned about their own future, The Americans are leaving and you mark my word they will in a short time they will begin to have differences because this is a sinking ship."


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Kids' chicken kebabs
Photo by Tamara West
I like the concept of kebabs. Pretty much anything can go on a bamboo skewer; you can make them fast if you are short on time, or if really organised have them marinating all ready to go. The kids can help with the threading on and also learn and take responsibility for the cooking process (depending on age of course).
|½ tsp
|Garlic, grated (optional)
|2 tsp
|Runny honey
|½ tsp
|Ginger, ground
|2 tsp
|Soy sauce
|2 tsp
|Olive oil
|600 g
|Chicken tenderloins
|Bamboo skewers, soaked in cold water for 30 minutes
- Mix the five marinade ingredients together, then add the chicken and thoroughly rub into the tenderloins. Leave to marinate for up to 12 hours. Thread on bamboo skewers.
- Cook under a hot grill, or on the barbecue for 8-10 minutes. Serve with "mountains" of steamed rice made by gently pressing hot rice into lightly greased cups. Tip out and conquer with a flag on top!


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Convocation is a special time to honour the hard work and dedication of the Insurance Institute's newest graduates of the Fellow Chartered Insurance Professional (FCIP), Advanced Chartered Insurance Professional (ACIP), and Chartered Insurance Professional (CIP) programs as well as recipients of the Risk Management, Commercial Insurance and General Insurance Essentials (GIE) certificates. It is an opportunity for the insurance community to come together and commemorate the professionalism of the industry and its people.
Save the date for the 2019 Convocation:
November 21, 2019
11:15 a.m - 3 p.m.
The Double Tree West Edmonton, Mayfield Dinner Theatre
16615 - 109 Ave. Edmonton, AB
Pat Van Bakel, BA, CIP
President & CEO - Crawford & Company (Canada) Inc.
Pat is a seasoned insurance industry professional with an impressive career that has resulted in a successful leadership journey and impressive business results. Over his 26 years of experience, Pat has developed strong business relationships and is a well-respected leader in the P&C industry.
Pat is a visionary leader focused on developing high performing teams and an engaged employee culture with a laser focus on delivering best in class customer experiences.
Pat is currently President and CEO of Crawford Canada and serves as Chairman of the Board for Origin and Cause; Canada's largest Forensic Engineering and Fire Investigation Consulting Firm specializing in cross-disciplinary forensic expertise. He is also elected to the Board of Governors of the Insurance Institute of Canada.


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Shipments to Canary Islands, Balearic Islands, Ceuta and Melilla call to (+34) 932 631 744
From 3000€ only to Peninsula
Our SPA model Neptun (M-3322) is the best option, if you look for a gift for the whole family. Thanks to the digital system that controls the temperature of the water at any time it is possible to adjust the temperature that best suits you with a few pulsations and forget about the SPA. As soon as the temperature is reached the SPA will turn the heater off automatically.
Este artículo tiene peso elevado y dimensiones que dificultan la entrega estándar.
Por favor consúltenos llamando al: (+34) 932 631 744 para poder realizar la compra.
Warning: Last items in stock!
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Price- 5.489,00 €
Transport Peninsula- 100.00 €
Transport Baleares- 670.00 €
Transport France- 150.00 €
Orders to Canary price is subtracted 21% VAT and add freight (including fees and taxes) of 1200.00 €
NOTE- Transportation is, to the customer's door.


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Mobile Marketing Agency Gold Coast
Smartphones have altered the marketing game forever. But as rapidly as smartphone technology evolves, your mobile-marketing strategy needs to also, and that is where we come in.
According to the 'Internet Trends 2017' by Mary Meeker's, she says that people spend 3.1 hours of every day on their mobile devices which delivers is a huge opportunity for companies to meet their target audience.The number of smartphone users is constantly growing and it far outnumbers PC users, which is why the possibility of reaching that audience within this network shouldn't get overlooked.
Our Mobile marketing agency Gold Coast uses customised methods for each client, to create better user experience that extend beyond all the traditional banner ads, which can easily get overlooked on a mobile screens, which inturn offers greater possibility to reach the audience whenever, wherever. Our Digital Marketing Gold Coast strategies are designed to target a far more specified audience based on not only to age, gender as well as locality, but additionally to interests and mobile browsing data, as well to other factors which present the opportunity to reach any specific target segment, within a specified audience profile.
Here at First Page SEO, we are the industry leaders in building websites that sell. Our implementation solutions are specifically tailor-made to reach your specific needs. Following that, as also a leading Web Marketing Gold Coast team, we have the tried and tested methods and know how to manage your entire mobile marketing campaign from strategy overview, audience profiling, campaign design and development, right down to delivery and reporting of your project. There is so much that can be done using mobile marketing to generate leads and product sales to your business using Mobile Marketing.
Our Mobile Marketing Agency Gold Coast will produce a bespoke analysis of your mobile marketing strategy tailor-made to meet business requirements. Do not lose out on out on a huge business opportunity – get mobile!
Mobile First Design
We ensure a great browsing experience for all users with focused efforts on mobile and desktop.
Accurate Targeting
We know the potential for mobile marketing for business success that's why our mobile campaigns are based on accurate targeting.
SMS Campaings
We use a cross-channel approach that integrates various mobile channels including SMS mobile marketing campaigns.
Our case studiesSee all projects
Tell us about your Online Marketing Gold Coast project
Let us help you get your business online and grow it with passion
Contact us and we will provide a Mobile Marketing strategy that will bring significant returns on investment. Mobile really is simply one marketing channel. The fact that said, it's an ideal method to initiate generating passive income from your website.
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"I had been in business for 3 years and relying on local business with the occasional website sale but it just wasn't enough. I knew I had to take advantage of the upcoming racing season. When I first contacted First Page SEO, I expected to be bombarded with technical jargon I didn't understand and thought getting to the first page of google within 3 months would be impossible - but I was pleasantly surprised! Everything they explained made perfect sense and they really narrowed the best keywords for me to maximise web traffic. I couldn't be more happy with the popularity of my site and the record year of sales I have experienced since hitting the first page of google."


text: Soar above Helium on the new Aerial Ropes Course and navigate more than one dozen different obstacles on a course built the perfect size for our Helium guests. And just below, look out for other guests who are attempting to conquer the Warrior Obstacle Course. You will be harnessed in, and sent out for your adventure. We wish you a safe return. Closed-toe shoes required for use of this attraction.


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Baking: Peanut butter cookiesSunday, September 08, 2013
Baking sometimes requires a lot of ingredients that are sold in pots and packets far too big. They will last forever, which is good if you are a big baker but not so good a deal if you know you are going to be leaving them behind after a few months of occasional baking... because lugging unnecessary luggage when you are on the go, is a no-no.
I found a four-ingredient cookie recipe online, via Pinterest. Only four ingredients?! Of course I'll give it a go!
- 1 C peanut butter
- 1/2 C sugar
- 1 egg
- 1 t vanilla extract
- Preheat the oven 180 degrees Celsius
- Combine all, spoon them onto the baking paper
- Bake for about 15-20 minutes
- Cool before consuming
The cookies were very, very sweet. It was very peanut buttery, which was nice, though. There's another peanut butter recipe I want to try out soon, so will let you know how it goes!


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Here's the thing with places that have Udipi (or Udupi or some variation thereof) in their names, especially if they position themselves as purveyors of pure vegetarian South Indian food. Since there is no Central Authority that performs a rigorous 64-point check by a team of experts before giving out an Udipi certification, this is pretty much a self appellation, and is no indication of the quality of food served there. Therefore, any restaurant I come across newly that has the word Udipi in its name is automatically viewed with much suspicion. This careful approach is the result of being scarred by numerous charlatanly fellows who have put the name Udipi in their names just by dint of dumping a ton of sugar in every savory dish they flog to unsuspecting passersby. Now I have become an extremely suspecting passerby – I pass by any new Udipi place with a lot of suspicion for a reasonably unreasonable amount of time before I venture inside and perform the ultimate test of Udipi-ness – order a masala dosai and a coffee.
Now that I have rambled on enough about Udipi restaurants and my automatic suspicion of them, let me get to the one I'm writing about today. Kondapur, while being an excellent location in many senses, is not exactly a bastion of decent South Indian vegetarian food. While you can get masalas, curries, rotis and biryanis to your heart's content (there's even a restaurant called MRCB – which actually stands for the abovementioned items!), when it comes to idlis, vadais, dosais and sambhar, you might as well be in Outer Mongolia. So, it was quite a revolution that Udipi's Upahar opened up a branch here. It has been crowded since day one, and that usually means me giving it a wide berth – I do not like waiting for my food a second longer than I have to – my hanger is legendary!
This past Sunday, I was presented with the golden opportunity to try out the place – I was on my own for breakfast (a happy accident resulting from a last-minute ditch and me forgetting that my cook could actually have made me breakfast, to Vidya's extreme annoyance), and I had enough time to do a detailed investigation of Udipi's Upahar. As I walked in, it was immediately clear they were doing something right – a mini riot was going on near the self service counter, as a crowd of enthusiastic breakfast-eaters milled about trying to get their orders. What was crazy was that most of them had a happy look on their faces – clearly they were having fun while waiting for their food.
I walked to the counter and placed my order – a plate of idli-vada, a masala dosai and a coffee. This is the perfect order if you want to test a South Indian vegetarian place – it allows you to judge very quickly if they actually have a South India cook. The chap at the cash counter was really fast, confident and wrong. He was very enthusiastic, but rather short on listening skills. He took three tries to get my order correct in his machine. Thankfully, someone had drilled into him the importance of repeating the order to the customer, and that was how I knew the number of attempts he had to make.
Armed with three different receipts, I dived into the mosh pit that was the delivery counter and started waving wildly at the three fellows trying to keep it sane. To be fair, they were doing quite a creditable job, and were extremely quick. The hold up was happening because of people who forgot to pick up their orders completely. Since my first receipt was for idli-vada, which were ready made, I was in and out very quickly – the receipt was snatched from my hand and the order yelled out. I was taken aback at the quickness with which it was assembled on a plate – one of the fellows yelled out the order, and as he yelled it out another was assembling the idli and vadai, while yet another had loaded another part of the plate with a dollop of solid chutney, and two bowls. The yeller, in the meantime had grabbed two ladles, one with sambar and another with liquid chutney, and sloshed them into the bowls, and the plate was thrust at me. The entire operation must have taken around 18.2 seconds, and I got some idea of what it feels like being in a Ferrari pitstop.
I retired to one of the stand-and-eat stainless steel tables, where the food passed every test. The idli was soft and fluffy without being insubstantial. The vadai was crunchy on the outside and soft on the inside, and had the right amount of sponginess to soak up the sambar. The sambar (aah the sambar – the shibboleth of a South India cook!) was actual Udipi sambar – which means it was payasam masquerading as a savory dish. Nevertheless, it was authentic, well balanced, and even managed to make me eat a few spoonfuls (I am really not fond of sweet sambar). The chutneys were both very well made – both in terms of balanced flavors and texture. They definitely have a South Indian cook.
Once I had polished off the idli and vadai, I had to go back to pick up the masala dosai. However, I had earlier spotted a coffee filter in the coffee counter – another sign of authenticity. Since I am a sucker for good filter coffee, and the quantity of coffee you get at these places is ridiculously small, I decided I'd have one now and get another to finish off. So I went up to the coffee counter, and witnessed the assembling of my cup of filter coffee – what a joy it is to behold! The fellow put the decoction into the cup, put it on the counter in front of me, and poured out the frothing hot milk into it! Up rose an aromatic frothy coffee that was just right – the color, aroma and taste were perfect! The right amount of chicory gave it a bit of a bitter edge. This place was turning out to be a winner.
Once more, I went into the breach – this time for my masala dosai. The mosh pit was less moshy, and I got to actually stand by the counter and watch the folks in action for a bit. As I paid attention to their conversation, I realized all the fellows behind the counter were Odia. They were quite perfectly coordinated, and worked like a well-oiled machine. My masala dosai appeared in record time, and back I went to the steel table. The dosai was an all round winner. Crisp where it had to be, soft where it had to be, perfectly fermented batter, the right amount of oil with a potato filling that was neither overpoweringly flavored nor too much in quantity. I had no complaints as I demolished it quickly.
After this, I resisted the urge to order another dosai, and just got myself a filter coffee. This time, it was the turn of the cash counter to become a mosh pit, and again, I successfully navigated it without having to bodysurf. My secret was holding the right amount of change in my hand and sticking it in front of the cashier's face – it was bait he could not refuse!
I chose to relish my second coffee at one of the communal seats – I shared mine with a couple and another chap – which are another feature of these in and out eat-quick places. Since I was sitting down, I took my time with the coffee, which was every bit as good as its predecessor.
I walked out with a wide grin on my face – Kondapur has definitely arrived in terms of having South India vegetarian options, though I wouldn't go so far as to call it a bastion yet. Udipi Upahar is a good option if you want good, decently priced South Indian vegetarian fare.
I definitely recommend the idli, vadai, masala dosai, and as much filter coffee as you can handle!


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Emini Trading Update – Tuesday 18 Mar 2014 (8:41)
The Zombie market continues – just refuses to die. So let's see what FOMC brings tomorrow. And if Putin just walks into the Eastern Ukraine next.
In the meantime, the day trading continues. And today's video is all about "you're safe until the blue Professional bars come in".
Remember, on FOMC day typically the first 30 minutes is a little lively. But then we can go very quiet with no significant moves until the announcement in the afternoon. It's easy to over-trade that quiet time, hoping for a decent move. But the safest play is to just wait it out.
Good luck with your Emini trading.


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Ftrace Function Graph ARM
This page holds information from Tim Bird's talk at Linux Symposium Montreal (July, 2009). Tim talked about patches against the 2.6.31-rc1 kernel tree for adding function graph tracing to the ARM architecture, for the Ftrace system.
Here is the presentation from the symposium session:
Here is Tim's paper for this work:
The following patches were submitted to the kernel mailing list in early July 2009. There are patches against kernel version 2.6.31-rc1.
- Media:Arm-sched_clock-notrace.patch
- Media:Add-function-graph-tracer-support-for-ARM.patch
- Media:Func-graph-duration-filter.patch
- Media:Optimize-duration-filter-discard.patch
- Media:Ftd.txt - Function Trace Dump - post-trace analysis tool
To install:
* Download * rename to 'ftd': mv Ftd.txt ftd * make it executable: chmod a+x * Put it on your path somewhere: sudo mv ftd /usr/local/bin


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In The Scripting Games this year, more than a few folks took the time to write detailed comment-based help. Awesome. No debating it – comment-based help is a good thing.Â
But some folks felt that others took it too far. There were definitely scripts where the authors used, for example, the .NOTES section to explain their thinking and approach. Some commenters felt it was excessive, while others have pointed out, "wow, what if every programmer gave us some idea what the heck he/she was thinking at the time?" Some felt these extensive comments were just at attempt to get a better score by "convincing" the reviewer of an approach or tactic; others felt, "so what?"
So let's leave the Games out of this debate – in a production environment, where do you come down on extensive notes in a script? When is it not enough, and when is it going too far? Where's the value, and where's the annoyance?
[boilerplate greatdebate]


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Many Rivers to Cross
What Are Genetically Engineered Drugs Doing to Our Water Supply?
Glen Boyd's students didn't know what they might find as they dipped containers into the water and took them back for tests. What turned up? Medicine.
There was cholesterol medication. There was the hormone estrone, a form of the estrogen prescribed to help menopausal women. And there was a strong pain reliever called naproxin. Low levels of these medications have also shown up in surface waters in other parts of the world.
While no one claims this mildly revved-up water hurts humans—it is further diluted before it reaches home faucets—some scientists are concerned about negative effects on the environment. And with a flood of new drugs as findings from the Human Genome Project are released, researchers wonder: How many more medications will end up in rivers and lakes?
After all, drug companies now target about 500 known biochemical receptors in the human body. That number is soon expected to jump as much as 20-fold—to 10,000 targets, says Environmental Protection Agency scientist Christian Daughton.
"The enormous array of pharmaceuticals will continue to diversify and grow as the human genome is mapped," says Daughton, whose research on the topic appeared in the peer-reviewed journal Environmental Health Perspectives. He says the large number of drugs being introduced "is adding exponentially to the already large array of chemical classes, each with distinct modes of biochemical action, many of which are poorly understood."
Researchers say drugs reach rivers and streams the old-fashioned way: With each flush of the toilet, body wastes containing traces of pharmaceuticals leave for septic tanks, which too often leak. Or they flow through wastewater treatment facilities that don't scrub pharmaceuticals from water. From there, the water that once sat in toilets and bathtubs eventually rejoins rivers and lakes, especially when storms rush in, overwhelming storm and sanitary sewers.
What does this mean for the environment? Many chemicals are designed to profoundly affect humans' physiology. Therefore, Daughton says, it wouldn't be surprising if they affected fish, birds, frogs and insects, as well. Yet, unlike pesticides, these drugs—as well as shampoos, sunscreens and other personal care products rushing down the drain—aren't examined for their effect on the environment before they're placed on the market. "This is surprising," Daughton says, "especially since certain pharmaceuticals are designed to modulate endocrine and immune systems." Hence, they "have obvious potential as endocrine disruptors in the environment."
Some products, meanwhile, have "very high acute aquatic toxicity," Daughton reports. It's impossible to predict how many of the pharmaceuticals would affect nature. After all, scientists don't even understand the process by which some drugs affect humans. After Canada's federal environmental agency, Environment Canada, found high levels of estrogen and birth control compounds in the effluent of sewage treatment plants in 1998, a Trent University researcher replicated these conditions in a laboratory, reports Rachel's Environment & Health Weekly. Some fish developed characteristics of both sexes.
Lots of water sources are apparently affected. Field studies conducted at wastewater treatment plants in California, Arizona and Texas found in their recycled sewer water a substance called organic iodine—a chemical used in medicinal
X-ray examinations, says Joerg E. Drewes, associate director of Arizona State University's National Center for Sustainable Water Supply. These seem to be slow to break down in the environment; they were still found at high concentrations in groundwater six to 12 months later.
Drewes has found plenty of chemicals in treated wastewater—an antibiotic, a chemical used in perfume production, the muscle relaxant drug carisoprodol, and its metabolite meprobamate, among others. Meanwhile, in metropolitan Kansas City, more than 40 percent of stream samples analyzed by U.S. Geological Survey scientist Donald Wilkison had detectable concentrations of common over-the-counter drugs—notably ibuprofen and acetaminophen—as well as prescription medicines for high-blood pressure (diltiazem) and antibiotics (trimethiprim-sulfamethoxazole). Even more stream samples—60 percent—had detectable levels of an anti-bacterial agent found in newfangled soaps (triclosan). "Deleterious environmental impacts are likely, either as agents of endocrine disruption, or through direct harm to bacterial and aquatic health," Wilkison reports.
While this rash of new drugs portends bad news for the environment, there could just as easily be good news, some scientists say.
The genomics revolution may make it possible for doctors to more finely target drugs to particular types of people. How many times have you tried a variety of medications to knock out a cold before finally landing on one that works? "It seems to me that we are entering a phase where we will understand more about individual's drug metabolism," says Dr. Paul R. Billings, co-founder of GeneSage, an Internet-based health company that provides genetic information, services and products. "That might reduce overall drug use. It will also allow us to subtype humans and ask if environmental influences affect all the same or differ."
"I think it's a pretty far stretch to draw a conclusion one way or another," says Taylor Crouch, CEO of Variagenics, a leading Boston-area company that applies genetic-variance information to the drug development process. "You could argue that if we get patients on more appropriate medications, they'll metabolize them better, more efficiently and, therefore, we would see less drug waste. But that's not necessarily provable." Yet, he adds, "to the extent that we can get less trial-and-error medications into patients," he does predict "a slight decrease in the overall excreted medications."
So, what does the future hold? It depends. If manufacturers are aware that some personal-care products "survive and potentially accumulate in the environment, they might design more biodegradable agents," says Drewes, adding, "We have to change something, that's for sure."


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DETROIT — When Ford Motor Co. came out with its new Edge crossover in 2006, the company hoped the truck-like vehicle built on a car frame would attract longtime Ford buyers trading in their inefficient sport utility vehicles.
For a while, it worked well. But last month, sales of the Edge and nearly all crossover vehicles dropped dramatically, causing another worry for automakers struggling with the dramatic shift by U.S. auto buyers from trucks to cars.
Automakers and some industry analysts say it's a temporary lull due to a combination of economic worries, sliding SUV values that prevent people from trading them in, and the lingering shock of $4 per gallon gasoline.
But if the trend continues, it's another blow to the profits at Ford, General Motors Corp. and Chrysler LLC, all of which have developed crossovers to capture their traditional SUV and truck buyers.
"The tough part is that's where the U.S. domestics are used to making their money, on people-haulers," said Mark Warnsman, an analyst with Calyon Securities.
The crossover market as a whole peaked this year in March, with all automakers selling 222,055, according to Autodata Corp. Sales dropped in April, rebounded in May and then slid in June to 184,871, down nearly 17 percent from March.
Even the Honda CR-V, a perennial top seller, saw a 21 percent decline in sales from May to June.
George Davis, general manager of Howard Cooper Honda in Ann Arbor, blamed the decline in part on tumbling SUV values and a knee-jerk reaction to high gasoline prices.
"Like everything else, we do overreact," he said. "It's basically sell the SUV, don't even consider another SUV, make sure you get a high gas mileage sedan."
Davis said buyers now are looking for cars that get as close to 40 miles per gallon as possible, shunning even the CR-V, a small crossover that gets up to 20 mpg in the city and 27 on the highway.
Many SUV owners have been stunned when told they would get only $20,000 in trade for a vehicle they paid $35,000 or more for just a short time ago, Davis said.
"They're in a trance. They're paralyzed," he said. "People have never experienced this kind of depreciation because there's just no market for their vehicle."
Midsize SUVs, on average, lost 28.7 percent of their value, from $15,577 in March 2005 to $11,096 at the end of June, according to wholesale auction data from the National Automobile Dealers Association. The figures are adjusted for variations in vehicle mileage.
Many SUV owners who typically would trade for crossovers owe more on their vehicles than they can sell them for, said Aaron Bragman, an auto analyst with the consulting company Global Insight. As a result, they have to keep them and continue buying more gasoline, he said.
"They're typically trading down from larger vehicles, and right now, the resale values of those vehicles are in the toilet," Bragman said.
Generally, truck-based SUVs get in the low teens in city gas mileage and in the upper teens on the highway.
Paul Taylor, the NADA's chief economist, said crossovers, which vary in size but generally get in the high teens in the city and mid-20s in highway gas mileage, are boxier than cars and right now are being shunned to a degree by buyers. Analysts also say buyers associate crossovers with six-cylinder engines when people now are looking for four cylinders.
"They're not even consulting the EPA rating or any other indicator of gas mileage," Taylor said. "They see the big box and see that's not enough mileage to suit me."
Taylor says a glut of used SUVs is fueling a trend toward people parking the big vehicles in the garage and buying small cars for their daily errands. The SUVs come out only when they're needed for hauling or towing, he said.
But Bragman said many buyers, who also have seen their house values decline, are too tapped out to buy anything else.
At the Honda dealership, Davis says his staff advises people in that situation to go for a used small car and keep their SUVs.
"The hit's too big, and they don't want to invest $20,000 or $25,000 in a new car as an additional car," he said.
Many industry analysts expect the crossover slump to continue but end when people eventually trade in the SUVs that are on the road now.
But in the interim, lower-profit small cars are taking up more and more of the market, and that means automakers are making far less profit per vehicle than they make on SUVs or crossovers.
Automakers don't release how much they make per vehicle, but an automaker used to be able to make a profit of $10,000 or more on a high-end SUV, said Jesse Toprak, chief industry analyst for auto information site Edmunds.com.
Auto companies make less on crossovers, although it's not clear how much because they vary so much in size and equipment, he said. And that gap is closing as SUV values continue to plummet, Toprak said.
Many industry analysts worry that the longer the crossover slump lasts, the more cash the troubled Detroit Three will burn as they try to survive the economic downturn. All have lost billions in the past few years as the market has shifted away from trucks to cars.
But George Pipas, Ford's top sales analyst, doesn't see the crossover slump as long-term.
"It's a concern in the sense that it limits the sales potential right here and now," he said. "There are still millions, literally, of Explorers on the road, multimillions of SUVs on the road. Eventually these will get traded."
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Finding that perfect destination wedding bridesmaid dress doesn't need to be an arduous journey. Take some time, look around and get a feel for what you would like your wedding and bridesmaids to look like. The choices are really endless.
This can be a really fun part of wedding planning. Get your fiends and family together and go! Having your bridesmaids be part of the process can be really fun.
Looking for great beach wedding bridesmaid dresses can seem like a real task, this can really be fun though. Get your ideas together of what you want your wedding to look like and then talk with your bridesmaids. You may find they have some really good thoughts that you may not have come up with.