text:
I have gone back and forth on whether or not I wanted to share this. I've written it out a million times in my head, but now I'm finally putting it to paper (or keyboard). I've been afraid to share it because the last thing I want is for you to feel sorry for me. I'm fine. We're fine. I'm writing this out now for two reasons. 1. Writing is my form of therapy. 2. Hearing other people's stories, especially my friends, helped me realize I'm not alone. My hope is this helps other families going through the same.
This summer my husband and I decided we were ready to grow our family. We'd settled in our new house. Jace was 14 months old, and we wanted him to be a big brother. Mario and I each have siblings that are far apart in age, so it was important for us to have another baby closer to Jace's age. Part of me was hesitant to start trying. We had finally found some normalcy within our crazy travel schedules. For the first year of Jace's life, I constantly felt like I was trying to keep my head above water- managing work, first time mom, etc. But now life was steady. How would throwing another baby in the mix change things? How was I going to manage football season, taking care of Jace, and feeling like crap during the first few months? Then we got pregnant. All those fears went out the window.
Not going to lie, it was rough those first months. Jace is a wild man, and trying to chase after him while wanting to sleep all day/throw up all day wasn't easy. Trying to cover a football game in 100 degrees, not fun. As Mario can attest, I'm not the most pleasant pregnant woman. But we were almost to the second trimester. We had names picked out. We'd told our families. We bought this cute little baseball shirt for Jace to wear when we announced our new addition. I was no longer scared about managing a family of four. I was thrilled!
One Monday morning, at ten weeks pregnant, I started bleeding. It wasn't very much, but it was still alarming. We went into the doctor for an ultrasound. They couldn't find the baby. There was a pregnancy, but no baby. We did some blood work, and the doctor told me to come back in a week, and we would have a more definitive answer then.
Deep down inside I knew we'd lost the baby. But I tried to hold on to any hope. You do enough google searches and you'll find miraculous stories about women who couldn't see the baby, and go on to have healthy pregnancies. Maybe this would be me. Mario tried to be supportive, but I was furious at him. He would never understand what I was going through. Mentally I knew I'd had a miscarriage, physically I hadn't miscarried yet. It was a waiting game to see if nature would step in or if we would have to schedule a D&C the next week.
That Thursday I left for my football game. That day, while going through TSA security, I had a miscarriage. For anyone who has ever gone through it (I will save you the gross details), having a miscarriage in the DFW airport is not ideal. In fact, it's pretty much horrible. I fly in and out of that same terminal every week. It's an awful reminder. Against my family's urging, I chose to get on my flight and go to work. I know my bosses would have been supportive in letting me stay home, but I needed a distraction. For a week this miscarriage consumed my every thought. I needed to focus on something else. I needed to do something else other than cry.
For the next few weeks I blamed myself. I felt like this was some sort of punishment for being scared to have another baby. Blame turned into relief. I had started to feel like my normal self again, which was a nice change. I wasn't sick or tired anymore. I was back to being a fun mom for Jace. But then you feel bad for feeling normal. I've come to realize that we all grieve in our own way.
Please don't feel sorry for us. We are doing much better. I've found some solace in the idea that this was just not a healthy pregnancy. A good friend of mine who's had her own miscarriage told me "You'll see you baby again in heaven one day." Honestly, at the time it was a little too much. A little too real. But as time has passed, it's helped me cope.
Mostly though, I'm sad for Jace. They would have been two years apart. They would have been best friends (and probably worst enemies at times). Jace would get to walk his younger brother/sister to school. He would be the best big brother. I'm sad for my husband that I wasn't able to give him another baby right now. But we had one healthy baby. I know we can have another.
I'm writing this now because the only way I got through this was from the help of my friends. Miscarriage is not talked about enough. You feel like you're the only one. But you're not. So many of my friends have been through one, and I never knew. Talking with them about it helped me cope. It helped me realize that it's not rare, and that I could go on to have a healthy pregnancy. If you're struggling, please know you're not alone.
Next time around there won't be any hesitation. This whole ordeal helped me realize how much we want another child. The nausea, lack of sleep, the sheer craziness is all temporary. My only hope is that in my next pregnancy I won't become a crazy person, constantly worried about another miscarriage. I know myself, and I have a hard time shutting my brain off. I hope I can find some strength not to be constantly worried. Maybe I'll take up yoga.
Thank you all for reading and letting me share my story. It's helped finally putting it into words.


text:
During these hard times ASAP Heating & Cooling is offering FREE SERVICE CALL'S to anyone in need of AC Service, not just our existing customers! We are doing our best to keep everyone calm during this stressful time.
We have a full staff that is dedicated to keeping our community safe, healthy and cool during these trying times.
Air Conditioning and Heating in Cape Coral, FL
Professionalism at Its Best – Air Conditioning Solutions for Your Home
Meeting All of Your Heating and Cooling Needs. Your Air Conditioning System Will Love It!
From routine AC repairs and air conditioner maintenance to expert HVAC equipment installation and replacement, ASAP Heating and Cooling is prepared to meet all of your heating and cooling needs. Give us a call at 239-567-9661 to discuss your air handlers, heater, air conditioning and other comfort concerns. We are located in Port Charlotte, Cape Coral, Naples and surrounding Southwest Florida Service Areas. Air conditioning is our business, and we take it seriously. With pride, honesty and commitment, we want to ensure your AC system works perfectly.
Air Conditioning
An air conditioning unit you can count on makes all the difference in your comfort on those hot days. Your air conditioner will not only keep you cool, but create an indoor climate that promotes good health. ASAP Heating and Cooling provides comprehensive services for all air conditioning systems, from installation of new units to maintenance and repair service for your existing AC system. Click here for more information.
Duct Cleaning
The dust and debris lurking in your duct system can create dirty indoor spaces and pollute the air you breathe. ASAP Heating and Cooling performs duct cleaning to eliminate these issues. Cleaning your ducts is a step in the right direction towards improving your indoor air quality. Click here for more information.
Air Quality
The quality of air you breathe inside your home makes a big difference to your comfort level as well as your health. ASAP Heating and Cooling offers a number of products and services which are designed to fill your home with cleaner, quality air. We will assist you in diagnosing the air quality issues affecting your home and determining which solutions will work best for you. Click here for more information.
Stay warm on the coldest of days with a reliable heating syste
m. We provide quality installation for new furnaces and heating systems, designed to help your new unit perform at its best. We also offer maintenance services which keep your system in shape, and in the event you experience trouble with your heating system, you can count on ASAP Heating and Cooling for skilled repairs. Click here for more information.
We are now a licensed contractor for Aeroseal.
Duct Sealing Overview | Duct Sealing FAQ

subset: commoncrawl


text:
He's won two state championships, earned a basketball scholarship to the University of Arizona, and secured a roster spot on Team USA for the Nike Hoops Summit in April.
What's left for Rondae Jefferson to accomplish during his senior year at Chester (Pa.) High School?
"I want to make my teammates better," Jefferson says. "That's what I take pride in first."
Perhaps that's not what you'd expect to hear from a guy who's ranked among the top 20 basketball players in the class of 2013. But then, Jefferson isn't your typical blue-chip recruit.
"Rondae is getting all the attention and exposure this year, but he's always talking up his teammates and trying to get them recognized," says Chester head coach Larry Yarbray. "He tells his teammates that without them, there is no Rondae."
Without Jefferson, however, the Chester Clippers might not have the opportunity to make history this season by winning an unprecedented third consecutive Pennsylvania Class AAAA state title. The first one came during Jefferson's sophomore year, when he made the varsity team after missing most of his freshman season due to injury.
"I played a big role on that team," Jefferson says. "I did everything and anything coach wanted me to do."
The do-everything forward says he "filled up the stat sheet" his junior year, averaging 12.9 points, eight rebounds, five assists and two blocked shots to lead the Clippers to their second straight state title. Jefferson's numbers are a testament to his team-first mentality, Coach Yarbray says.
"He's the type of guy that could average 20 points a night, easily," Yarbray says. "But he knows how to get his teammates involved and knows they're good players, so he puts them in position to be effective."
Jefferson would like to improve a little on the offensive end of the court. He says, "A lot of people say I can't shoot the jumper. I want to prove them wrong." But he is a dominating force on the defensive end of the court. His ability to thwart opponents' scoring attempts is one reason why Jefferson is the most hyped Chester player since Orlando Magic PG Jameer Nelson, who graduated in 2000, and why he was selected for the Nike Hoops Summit, where he and other top high school players will take on the best amateur players from around the world.
While state championships and national recognition are all good, the future looks even more promising. "I don't think the best has yet come," Jefferson says. "I'm just waiting patiently."
Photo Credit: Getty Images // Thinkstock


text:
doc721s | Graduate
Concept Paper Seminar
- Overview
- Topics
- Costs
This seminar is designed to focus on the development of the student's concept paper submitted in DOC/721R. The development and revision of the concept paper will be ongoing throughout this 3-week seminar. Topics in the seminar include problem statements, research questions, hypotheses and testing, samples and populations, and the intended impact of the study on the profession and society. The outcome of this seminar is a revised concept paper that articulates a specific goal and plan that will evolve into the student's dissertation. This seminar will incorporate students from various doctoral programs/disciplines.
This graduate-level course is 3 This course is available as part of a degree or certificate program. To enroll, speak with an Enrollment Representative.
Course details:
topic title goes here
Please ask about these special rates:
Teacher Rate: For some courses, special tuition rates are available for current, certified P-12 teachers and administrators. Please speak with an Enrollment Representative today for more details.
Military Rate: For some courses, special tuition rates are available for active duty military members and their spouses. Please speak with an Enrollment Representative today for more details.
The University of Phoenix reserves the right to modify courses.
While widely available, not all programs are available in all locations or in both online and on-campus formats. Please check with a University Enrollment Representative.
Transferability of credit is at the discretion of the receiving institution. It is the student's responsibility to confirm whether or not credits earned at University of Phoenix will be accepted by another institution of the student's choice.


text:
Smoking Simulator is, thankfully, a little more involved than the name suggests. This isn't a simulation of the act of smoking. It's a simulation of the act of trying not to (or to) kill everyone around you one the smokes run out.
The game was made for the same Indie Game Maker contest as Purrkour, which we featured last week.
It's playable in a browser (also: see Greenlight page), so you can smoke-then-smash-stuff right now if you'd like.


text:
Lymphoma - Related Links
Open Access Articles- Top Results for Lymphoma
Journal of Clinical Case ReportsCase of Bilateral Primary Testicular Lymphoma in a Chronic Renal Disease Patient
Oncology & Cancer Case ReportsNivolumab-Induced Rapid Tumor Remission of Pulmonary Adenocarcinoma
Journal of Blood & LymphHepatosplenic T-cell Lymphoma with Coexistent HIV and Malaria: A Rare Clinicopathologic Entity
OMICS Journal of RadiologyEpendymoma as a Secondary Malignancy after Treatment of Non- Hodgkin Lymphoma
Journal of Emerging Infectious DiseasesPlasmablastoid Lymphoma in Patients with Human Immunodeficiency Virus: A Diagnosis Challenge
File:Lymphoma macro.jpg
Follicular lymphoma replacing a lymph node
|Classification and external resources
|Hematology and oncology
|000580 000581
|Patient UK
Lymphoma is the name applied to a group of blood cell tumors that develop from lymphatic cells. The name often refers to just the cancerous ones rather than all such tumors.[1] Symptoms may include enlarged lymph nodes, fever, drenching sweats, weight loss, itching, and feeling tired.[2][3] The enlarged lymph nodes are usually painless.[2] The sweats are most common at night.[2][3]
There are dozens of subtypes of lymphomas.[4] The two main categories of lymphomas are Hodgkin lymphomas (HL) and the non-Hodgkin lymphomas (NHL).[5] The World Health Organization (WHO) includes two other categories as types of lymphoma: multiple myeloma and immunoproliferative diseases.[6] About 90% of lymphomas are non-Hodgkin lymphomas.[5][7] Lymphomas and leukemias are a part of the broader group of tumors of the hematopoietic and lymphoid tissues.[8]
Risk factors for Hodgkin lymphoma include infection with Epstein–Barr virus and a history of the disease in the family.[2] Risk factors for common types of non-Hodgkin lymphomas include autoimmune diseases, HIV/AIDS, infection with human T-lymphotropic virus, eating a large amount of meat and fat, immunosuppressant medications, and some pesticides.[3] Diagnosis, if enlarged lymph nodes are present, is usually by lymph node biopsy.[2][3] Blood, urine, and bone marrow testing may also be useful in the diagnosis.[3] Medical imaging may then be done to determine if and where the cancer has spread.[2][3] Spread is most often to lungs, liver, and/or brain.[2][3]Treatment may involve one or more of the following: chemotherapy, radiation therapy, targeted therapy, and surgery.[2][3] In some non-Hodgkin lymphomas, an increased amount of protein produced by the lymphoma cells causes the blood to become so thick that plasmapheresis is performed to remove the protein.[3] Watchful waiting may be appropriate for certain types.[3] The outcome depends on the subtype with some being curable and treatment prolongs survival in most.[5] The five-year survival rate in the United States for all Hodgkin lymphoma subtypes is 85%,[9] while that for non-Hodgkin lymphomas it is 69%.[10] Worldwide, lymphomas developed in 566,000 people in 2012 and caused 305,000 deaths.[6] They make up 3–4% of all cancers, making them as a group the seventh-most common form.[6][11] In children they are the third most common cancer.[12] They occur more often in the developed world than the developing world.[6]
- 1 Signs and symptoms
- 2 Diagnosis
- 3 Staging
- 4 Treatment
- 5 Prognosis
- 6 Epidemiology
- 7 History
- 8 Research
- 9 Other animals
- 10 References
- 11 External links
Signs and symptoms
Lymphoma may present with certain nonspecific symptoms; if the symptoms are persistent, an evaluation to determine their cause, including possible lymphoma, should be undertaken.
- Lymphadenopathy[13][14] or swelling of lymph nodes is the primary presentation in lymphoma.
- B symptoms (systemic symptoms) – can be associated with both Hodgkin lymphoma and non-Hodgkin lymphoma. They consist of:
- Other symptoms :
Lymphoma is definitively diagnosed by a lymph node biopsy, meaning a partial or total excision of a lymph node examined under the microscope.[15] This examination reveals histopathological features that may indicate lymphoma. After lymphoma is diagnosed, a variety of tests may be carried out to look for specific features characteristic of different types of lymphoma. These include:
Lymphomas sensu stricto are any neoplasms of the lymphatic tissues (lympho- + -oma) .[16] The main class are malignant neoplasms (that is, cancer) of the lymphocytes, a type of white blood cell that belongs to both the lymph and the blood and pervades both. Thus lymphomas and leukemias are both tumors of the hematopoietic and lymphoid tissues, and as lymphoproliferative disorders, lymphomas and lymphoid leukemias are closely related, to the point that some of them are unitary disease entities that can be called by either name (for example, adult T-cell leukemia/lymphoma).
Several classification systems have existed for lymphoma, which use histological and other findings to divide lymphoma into different categories. The classification of lymphoma can affect treatment and prognosis. Classification systems generally classify lymphoma according to:
- Whether or not it is a Hodgkin lymphoma
- Whether the cell that is replicating is a T cell or B cell
- The site from which the cell arises
Hodgkin lymphoma
Hodgkin lymphoma is one of the most commonly known types of lymphoma,[citation needed] and differs from other forms of lymphoma in its prognosis and several pathological characteristics. A division into Hodgkin and non-Hodgkin lymphomas is used in several of the older classification systems. A Hodgkin lymphoma is marked by the presence of a type of cell called the Reed–Sternberg cell.[17][18]
Non-Hodgkin lymphomas
Non-Hodgkin lymphomas, which are defined as being all lymphomas except Hodgkin lymphoma, are more common than Hodgkin lymphoma. There is a very wide variety of lymphomas in this class, and the causes, the types of cells involved, and the prognosis varies by type. The incidence of non-Hodgkin lymphoma increases with age.
WHO classification
The WHO classification, published in 2001 and updated in 2008,[19][20] is based upon the foundations laid within the "Revised European-American Lymphoma classification" (REAL). This system groups lymphomas by cell type (i.e. the normal cell type that most resembles the tumor) and defining phenotypic, molecular, or cytogenetic characteristics. There are five groups as shown in the table. Hodgkin lymphoma is considered separately within the WHO and preceding classifications, although it is recognized as being a tumor of, albeit markedly abnormal, lymphocytes of mature B cell lineage.
Of the many forms of lymphoma, some are categorized as indolent (e.g. small lymphocytic lymphoma), compatible with a long life even without treatment, whereas other forms are aggressive (e.g. Burkitt's lymphoma), causing rapid deterioration and death. However, most of the aggressive lymphomas respond well to treatment and are curable. The prognosis, therefore, depends on the correct diagnosis and classification of the disease, which is established after examination of a biopsy by a pathologist (usually a hematopathologist).[21]
- 3 to 4% of lymphomas in adults
- Small resting lymphocytes mixed with variable numbers of large activated cells, lymph nodes diffusely effaced
- CD5, surface immunoglobulin
- 50%.[22]
- Occurs in older adults, usually involves lymph nodes, bone marrow and spleen, most patients have peripheral blood involvement, indolent
- B-cell prolymphocytic leukemia
- Lymphoplasmacytic lymphoma (such as Waldenström macroglobulinemia)
- Splenic marginal zone lymphoma
- Hairy cell leukemia
- Plasma cell neoplasms:
- Plasma cell myeloma (also known as multiple myeloma)
- Plasmacytoma
- Monoclonal immunoglobulin deposition diseases
- Heavy chain diseases
- Extranodal marginal zone B cell lymphoma, also called MALT lymphoma
- About 5% of lymphomas in adults
- Variable cell size and differentiation, 40% show plasma cell differentiation, homing of B cells to epithelium creates lymphoepithelial lesions.
- CD5, CD10, surface Ig
- Frequently occurs outside lymph nodes, very indolent, may be cured by local excision
- About 40% of lymphomas in adults
- Small "cleaved" cells (centrocytes) mixed with large activated cells (centroblasts), usually nodular ("follicular") growth pattern
- CD10, surface Ig
- 72–77%[23]
- Occurs in older adults, usually involves lymph nodes, bone marrow and spleen, associated with t(14;18) translocation overexpressing Bcl-2, indolent
- 3 to 4% of lymphomas in adults
- Lymphocytes of small to intermediate size growing in diffuse pattern
- 50%[24] to 70%[24]
- Occurs mainly in adult males, usually involves lymph nodes, bone marrow, spleen and GI tract, associated with t(11;14) translocation overexpressing cyclin D1, moderately aggressive
- Diffuse large B cell lymphoma, not otherwise specified
- About 40 to 50% of lymphomas in adults
- Variable, most resemble B cells of large germinal centers, diffuse growth pattern
- Variable expression of CD10 and surface Ig
- 5-year survival 60%[25]
- Occurs in all ages, but most commonly in older adults, may occur outside lymph nodes, aggressive
- Diffuse large B-cell lymphoma associated with chronic inflammation
- Epstein–Barr virus-positive DLBCL of the elderly
- Lymphomatoid granulomatosis
- Primary mediastinal (thymic) large B-cell lymphoma
- Intravascular large B-cell lymphoma
- ALK+ large B-cell lymphoma
- Plasmablastic lymphoma
- Primary effusion lymphoma
- Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
- Burkitt lymphoma/leukemia
- < 1% of lymphomas in the United States
- Round lymphoid cells of intermediate size with several nucleoli, starry-sky appearance by diffuse spread with interspersed apoptosis
- CD10, surface Ig
- 5-year
survival 50%[26]
- Endemic in Africa, sporadic elsewhere, more common in immunocompromised and children, often visceral involvement, highly aggressive
- T-cell prolymphocytic leukemia
- T-cell large granular lymphocyte leukemia
- Aggressive NK cell leukemia
- Adult T-cell leukemia/lymphoma
- Extranodal NK/T-cell lymphoma, nasal type
- Enteropathy-associated T-cell lymphoma
- Hepatosplenic T-cell lymphoma
- Blastic NK cell lymphoma
- Mycosis fungoides / Sezary syndrome
- Most common cutaneous lymphoid malignancy
- Usually small lymphoid cells with convoluted nuclei that often infiltrate the epidermis, creating Pautrier microabscesseses
- 5-year
survival 75%[27]
- Localized or more generalized skin symptoms, generally indolent, in a more aggressive variant, Sézary's disease, skin erythema and peripheral blood involvement
- Primary cutaneous CD30-positive T cell lymphoproliferative disorders
- Primary cutaneous anaplastic large cell lymphoma
- Lymphomatoid papulosis
- Peripheral T-cell lymphoma not otherwise specified
- Most common T cell lymphoma
- Variable, usually a mix small to large lymphoid cells with irregular nuclear contours
- Probably consists of several rare tumor types, often disseminated and generally aggressive
- B-lymphoblastic leukemia/lymphoma not otherwise specified
- B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
- T-lymphoblastic leukemia/lymphoma
- 15% of childhood acute lymphoblastic leukemia and 90% of lymphoblastic lymphoma.[19]:635
- Lymphoblasts with irregular nuclear contours, condensed chromatin, small nucleoli and scant cytoplasm without granules
- TdT, CD2, CD7
- It often presents as a mediastinal mass because of involvement of the thymus. It is highly associated with NOTCH1 mutations, and is most common in adolescent males.
- Classical Hodgkin lymphomas:
- Nodular sclerosis form of Hodgkin lymphoma
- Most common type of Hodgkin lymphoma
- Reed-Sternberg cell variants and inflammation, usually broad sclerotic bands that consist of collagen
- Most common in young adults, often arises in the mediastinum or cervical lymph nodes
- Mixed cellularity Hodgkin lymphoma
- Second-most common form of Hodgkin lymphoma
- Many classic Reed-Sternberg cells and inflammation
- Most common in men, more likely to be diagnosed at advanced stages than the nodular sclerosis form Epstein-Barr virus involved in 70% of cases
- Lymphocyte-rich
- Lymphocyte depleted or not depleted
- Nodular lymphocyte-predominant Hodgkin lymphoma
- Associated with a primary immune disorder
- Associated with the human immunodeficiency virus (HIV)
- Post-transplant
- Associated with methotrexate therapy
- Primary central nervous system lymphoma occurs most often in immunocompromised patients, in particular those with AIDS, but it can occur in the immunocompetent, as well. It has a poor prognosis, particularly in those with AIDS. Treatment can consist of corticosteroids, radiotherapy, and chemotherapy, often with methotrexate.
Previous classifications
There have been several previous classifications, including Rappaport 1956, Lennert / Kiel 1974, BNLI, Working formulation (1982), and REAL (1994).
The Working formulation of 1982 was a classification of non-Hodgkin lymphoma. It excluded the Hodgkin lymphomas and divided the remaining lymphomas into four grades (low, intermediate, high, and miscellaneous) related to prognosis, with some further subdivisions based on the size and shape of affected cells. This purely histological classification included no information about cell surface markers, or genetics, and it made no distinction between T-cell lymphomas or B-cell lymphomas. It was widely accepted at the time of its publication, but is now obsolete.[28] It is still used by some cancer agencies for compilation of lymphoma statistics and historical rate comparisons.[citation needed]
In 1994, the Revised European-American Lymphoma (REAL) classification applied immunophenotypic and genetic features in identifying distinct clinicopathologic entities among all the lymphomas except Hodgkin lymphoma.[29] For coding purposes, the ICD-O (codes 9590–9999)[30] and ICD-10 (codes C81-C96)[31] are available.
After a diagnosis and before treatment, a cancer is staged. This refers to determining if the cancer has spread, and if so, whether locally or to distant sites. Staging is reported as a grade between I (confined) and IV (spread). Staging is carried out because the stage of a cancer impacts its prognosis and treatment.[citation needed]
The Ann Arbor staging system is routinely used for staging of both HL and NHL. In this staging system, I represents a localized disease contained within a lymph node, II represents the presence of lymphoma in two or more lymph nodes, III represents spread of the lymphoma to both sides of the diaphragm, and IV indicates tissue outside a lymph node.[citation needed]
CT scan or PET scan imaging modalities are used to stage a cancer.[citation needed]
Age and poor performance status are established poor prognostic factors, as well.[32]
Prognoses and treatments are different for HL and between all the different forms of NHL,[33] and also depend on the grade of tumour, referring to how quickly a cancer replicates. Paradoxically, high-grade lymphomas are more readily treated and have better prognoses:[citation needed] Burkitt lymphoma, for example, is a high-grade tumour known to double within days, and is highly responsive to treatment. Lymphomas may be curable if detected in early stages with modern treatment.
Low-grade lymphomas
Many low-grade lymphomas remain indolent for many years. Treatment of the nonsymptomatic patient is often avoided. In these forms of lymphoma, such as follicular lymphoma, watchful waiting is often the initial course of action. This is carried out because the harms and risks of treatment outweigh the benefits.[34] If a low-grade lymphoma is becoming symptomatic, radiotherapy or chemotherapy are the treatments of choice; although they do not cure the lymphoma, they can alleviate the symptoms, particularly painful lymphadenopathy. Patients with these types of lymphoma can live near-normal lifespans, but the disease is incurable. Some centers advocate the use of single agent rituximab in the treatment of follicular lymphoma rather than the wait and watch approach. Watchful waiting is not a good strategy for all patients, as it leads to significant distress and anxiety in some patients. It has been equated with watch and worry.[35]
High-grade lymphomas
Treatment of some other, more aggressive, forms of lymphoma[which?] can result in a cure in the majority of cases, but the prognosis for patients with a poor response to therapy is worse.[36] Treatment for these types of lymphoma typically consists of aggressive chemotherapy, including the CHOP or R-CHOP regimen. A number of people are cured with first-line chemotherapy. Most patients relapse within the first two years, and the relapse risk drops significantly thereafter.[37] For people who relapse, high-dose chemotherapy followed by autologous stem cell transplantation is a proven approach.[38]
Hodgkin lymphoma
Hodgkin lymphoma typically is treated with radiotherapy alone, as long as it is localized.[39]
Advanced Hodgkin disease requires systemic chemotherapy, sometimes combined with radiotherapy.[40] Chemotherapy used includes the ABVD regimen, which is commonly used in the United States. Other regimens used in the management of Hodgkin lymphoma include BEACOPP and Stanford V. Considerable controversy exists regarding the use of ABVD or BEACOPP. Briefly, both regimens are effective, but BEACOPP is associated with more toxicity. Encouragingly, a significant number of people who relapse after ABVD can still be salvaged by stem cell transplant.[41]
Palliative care
Palliative care, a specialized medical care focused on the symptoms, pain, and stress of a serious illness, is recommended by multiple national cancer treatment guidelines as an accompaniment to curative treatments for people suffering from lymphoma.[42][43] It is used to address both the direct symptoms of lymphoma and many unwanted side effects that arise from treatments.[44][45] Palliative care can be especially helpful for children who develop lymphoma, helping both children and their families deal with the physical and emotional symptoms of the disease.[44][46][47][48] For these reasons, palliative care is especially important for patients requiring bone marrow transplants.[49][50]
|Five-year relative survival by stage at diagnosis[51]
|Stage at diagnosis
| Five-year relative
survival (%)
| Percentage
of cases (%)
|Localized (confined to primary site)
|Regional (spread to regional lymph nodes)
|Distant (cancer has metastasized)
|Unknown (unstaged)
Lymphoma is the most common form of hematological malignancy, or "blood cancer", in the developed world.
Taken together, lymphomas represent 5.3% of all cancers (excluding simple basal cell and squamous cell skin cancers) in the United States and 55.6% of all blood cancers.[53]
According to the U.S. National Institutes of Health, lymphomas account for about 5%, and Hodgkin lymphoma in particular accounts for less than 1% of all cases of cancer in the United States.
Because the whole system is part of the body's immune system, patients with a weakened immune system such as from HIV infection or from certain drugs or medication also have a higher incidence of lymphoma.[54]
Thomas Hodgkin published the first description of lymphoma in 1832, specifically of the form named after him.[55] Since then, many other forms of lymphoma have been described.
The two types of lymphoma research are clinical or translational research and basic research. Clinical/translational research focuses on studying the disease in a defined and generally immediately patient-applicable way, such as testing a new drug in patients. Studies may focus on effective means of treatment, better ways of treating the disease, improving the quality of life for patients, or appropriate care in remission or after cures. Hundreds of clinical trials are being planned or conducted at any given time.[56]
Basic science research studies the disease process at a distance, such as seeing whether a suspected carcinogen can cause healthy cells to turn into lymphoma cells in the laboratory or how the DNA changes inside lymphoma cells as the disease progresses. The results from basic research studies are generally less immediately useful to patients with the disease,[57] but can improve scientists' understanding of lymphoma and form the foundation for future, more effective treatments.
An example of basic science research in lymphomas is the study of short non-coding RNAs named microRNAs (miRNAs). They have important functions in lymphoma biology. In malignant B cells, miRNAs participate in pathways fundamental to B cell development, such as B cell receptor (BCR) signalling, B cell migration/adhesion, cell-cell interactions in immune niches, and the production and class-switching of immunoglobulins.[58] MiRNAs influence B cell maturation, generation of pre-, marginal zone, follicular, B1, plasma and memory B cells.[58]
Other animals
- ^ Taylor, Elizabeth J. (2000). Dorland's Illustrated medical dictionary. (29th ed.). Philadelphia: Saunders. p. 1038. ISBN 0721662544.
- ^ a b c d e f g h "General Information About Adult Hodgkin Lymphoma". National Cancer Institute. 2014-04-23. Retrieved 20 June 2014.
- ^ a b c d e f g h i j "General Information About Adult Non-Hodgkin Lymphoma". National Cancer Institute. 2014-04-25. Retrieved 20 June 2014.
- ^ Aditya Bardia (2010). Johns Hopkins Patients' Guide to Lymphoma. Jones & Bartlett Learning. p. 6. ISBN 9781449631413.
- ^ a b c The Lymphoma Guide Information for Patients and Caregivers (PDF). Leukemia and Lymphoma Society. 2013. Retrieved 20 June 2014.
- ^ a b c d World Cancer Report 2014. World Health Organization. 2014. pp. Chapter 5.13. ISBN 9283204298.
- ^ "Lymphoma". NCI. Retrieved 13 June 2014.
- ^ Vardiman JW, Thiele J, Arber DA, Brunning RD, Borowitz MJ, Porwit A, Harris NL, Le Beau MM, Hellström-Lindberg E, Tefferi A, Bloomfield CD (Jul 30, 2009). "The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes.". Blood 114 (5): 937–51. PMID 19357394. doi:10.1182/blood-2009-03-209262.
- ^ "Hodgkin Lymphoma—SEER Stat Fact Sheets". Seer.cancer.gov. Retrieved 2012-08-26.
- ^ "SEER Stat Fact Sheets: Non-Hodgkin Lymphoma". NCI. Retrieved 18 June 2014.
- ^ Marcus, Robert (2013). Lymphoma : pathology, diagnosis and treatment (Second ed.). p. 1. ISBN 9781107010598.
- ^ Tepper, John E. Niederhuber, James O. Armitage, James H. Doroshow, Michael B. Kastan, Joel E. (2014). "Childhood lymphoma". Abeloff's clinical oncology (Fifth ed.). p. Chapter 97. ISBN 1455728659.
- ^ a b c d e f "About Lymphoma". Lymphoma Research Foundation. Retrieved 22 December 2012.
- ^ a b c d e f g h "Warning Signs of Lymphoma — First Signs of Lymphoma". Lymphoma.about.com. Retrieved 2012-12-01.
- ^ Mallick, Indranil. "How Is Lymphoma Diagnosed?". lymphoma.about.com. Retrieved 22 December 2012.
- ^ Elsevier, Dorland's Illustrated Medical Dictionary, Elsevier.
- ^ National Cancer Institute, "Hodgkin Lymphoma", http://www.cancer.gov/cancertopics/types/hodgkin, accessed on 2013-08-05
- ^ National Cancer Institute. "What You Need To Know About Hodgkin Lymphoma". U.S. Dept of Health and Human Services, (online at http://www.cancer.gov/cancertopics/wyntk/hodgkin.pdf), pg 4.
- ^ a b Jaffe, ES; Harris NL, Vardiman JW, Campo E, Arber, DA. (2011). Hematopathology (1st ed.). Elsevier Saunders. ISBN 9780721600406.
- ^ Swerdlow, Steven H.; International Agency for Research on Cancer; World Health Organization (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. World Health Organization classification of tumours 2 (4th ed.). International Agency for Research on Cancer. ISBN 9789283224310.
- ^ Wagman LD. (2008). "Principles of Surgical Oncology". In Pazdur R, Wagman LD, Camphausen KA, Hoskins WJ. Cancer Management: A Multidisciplinary Approach (11th ed.). CMPMedica. ISBN 9781891483622.
- ^ "Chronic Leukemias". The Merck Manual of Geriatrics.
- ^ Lymphoma, Follicular at eMedicine
- ^ a b
- 50% for limited stageLeitch HA, Gascoyne RD, Chhanabhai M, Voss NJ, Klasa R, Connors JM (October 2003). "Limited-stage mantle-cell lymphoma". Ann. Oncol. 14 (10): 1555–61. PMID 14504058. doi:10.1093/annonc/mdg414.
- 70% for advanced stageHerrmann A, Hoster E, Zwingers T, Brittinger G, Engelhard M, Meusers P, Reiser M, Forstpointner R, Metzner B, Peter N, Wörmann B, Trümper L, Pfreundschuh M, Einsele H, Hiddemann W, Unterhalt M, Dreyling M (February 2009). "Improvement of overall survival in advanced stage mantle cell lymphoma". J. Clin. Oncol. 27 (4): 511–8. PMID 19075279. doi:10.1200/JCO.2008.16.8435.
- ^ Turgeon, Mary Louise (2005). Clinical Hematology: Theory and Procedures 936 (4 ed.). Lippincott Williams & Wilkins. pp. 285–6. ISBN 978-0-7817-5007-3.
- ^ Diviné M, Casassus P, Koscielny S, Bosq J, Sebban C, Le Maignan C, Stamattoulas A, Dupriez B, Raphaël M, Pico JL, Ribrag V (December 2005). "Burkitt lymphoma in adults: a prospective study of 72 patients treated with an adapted pediatric LMB protocol". Ann. Oncol. 16 (12): 1928–35. PMID 16284057. doi:10.1093/annonc/mdi403.
- ^ Kirova YM, Piedbois Y, Haddad E, Levy E, Calitchi E, Marinello G, Le Bourgeois JP (May 1999). "Radiotherapy in the management of mycosis fungoides: indications, results, prognosis. Twenty years experience". Radiother Oncol 51 (2): 147–51. PMID 10435806. doi:10.1016/S0167-8140(99)00050-X.
- ^ Clarke CA, Glaser SL, Dorfman RF, Bracci PM, Eberle E, Holly EA (January 2004). "Expert review of non-Hodgkin lymphomas in a population-based cancer registry: reliability of diagnosis and subtype classifications". Cancer Epidemiol. Bio-markers Prev. 13 (1): 138–43. PMID 14744745. doi:10.1158/1055-9965.EPI-03-0250.
- ^ Non-Hodgkin Lymphoma at eMedicine
- ^ Archived June 27, 2004 at the Wayback Machine
- ^ who.int
- ^ International Prognostic Index N Engl J Med. 1993;329(14):987-94
- ^ Sweetenham JW (November 2009). "Treatment of lymphoblastic lymphoma in adults". Oncology (Williston Park, N.Y.) 23 (12): 1015–20. PMID 20017283.
- ^ Elphee EE (May 2008). "Understanding the concept of uncertainty in patients with indolent lymphoma". Oncol Nurs Forum 35 (3): 449–54. PMID 18467294. doi:10.1188/08.ONF.449-454.
- ^ Ansell SM (2014). "Follicular lymphoma: Watch and wait is watch and worry". The Lancet Oncology 15 (4): 368–9. PMID 24602759. doi:10.1016/S1470-2045(14)70066-X.
- ^ Bernstein SH, Burack WR; Burack (2009). "The incidence, natural history, biology, and treatment of transformed lymphomas". Hematology Am Soc Hematol Educ Program 2009: 532–41. PMID 20008238. doi:10.1182/asheducation-2009.1.532.
- ^ Jenkins EC (Jan 1972). "Wire-loop application of liquid emulsion to slides for autoradiography in light microscopy.". Stain technology 47 (1): 23–6. PMID 4550425. doi:10.3109/10520297209116530.
- ^ Philip T, Guglielmi C, Hagenbeek A, Somers R, Van der Lelie H, Bron D, Sonneveld P, Gisselbrecht C, Cahn JY, Harousseau JL (Dec 7, 1995). "Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma.". The New England Journal of Medicine 333 (23): 1540–5. PMID 7477169. doi:10.1056/nejm199512073332305.
- ^ Martin NE, Ng AK; Ng (November 2009). "Good things come in small packages: low-dose radiation as palliation for indolent non-Hodgkin lymphomas". Leuk. Lymphoma 50 (11): 1765–72. PMID 19883306. doi:10.3109/10428190903186510.
- ^ Kuruvilla J (2009). "Standard therapy of advanced Hodgkin lymphoma". Hematology Am Soc Hematol Educ Program 2009: 497–506. PMID 20008235. doi:10.1182/asheducation-2009.1.497.
- ^ Viviani S, Zinzani PL, Rambaldi A, Brusamolino E, Levis A, Bonfante V, Vitolo U, Pulsoni A, Liberati AM, Specchia G, Valagussa P, Rossi A, Zaja F, Pogliani EM, Pregno P, Gotti M, Gallamini A, Rota Scalabrini D, Bonadonna G, Gianni AM (2011). "ABVD versus BEACOPP for Hodgkin's lymphoma when high-dose salvage is planned". New England Journal of Medicine 365 (3): 203–12. PMID 21774708. doi:10.1056/NEJMoa1100340.
- ^ Ferrell B, Connor SR, Cordes A, Dahlin CM, Fine PG, Hutton N, Leenay M, Lentz J, Person JL, Meier DE, Zuroski K (2007). "The national agenda for quality palliative care: the National Consensus Project and the National Quality Forum". J Pain Symptom Manage 33 (6): 737–44. PMID 17531914. doi:10.1016/j.jpainsymman.2007.02.024.
- ^ *The American Society of Clinical Oncology made this recommendation based on various cancers. See American Society of Clinical Oncology, "Five Things Physicians and Patients Should Question" (PDF), Choosing Wisely: an initiative of the ABIM Foundation (American Society of Clinical Oncology), retrieved August 14, 2012
- ^ a b Higginson IJ, Evans CJ; Evans (2010). "What is the evidence that palliative care teams improve outcomes for cancer patients and their families?". Cancer J 16 (5): 423–35. PMID 20890138. doi:10.1097/PPO.0b013e3181f684e5.
- ^ "Palliative Care: It's for Caregivers Too, Says Study". Retrieved 2014-08-21.
- ^ Heath JA, Clarke NE, Donath SM, McCarthy M, Anderson VA, Wolfe J (2010). "Symptoms and suffering at the end of life in children with cancer: an Australian perspective". Med J Aust 192 (2): 71–5. PMID 20078405.
- ^ Schmidt P, Otto M, Hechler T, Metzing S, Wolfe J, Zernikow B (2013). "Did increased availability of pediatric palliative care lead to improved palliative care outcomes in children with cancer?". J Palliat Med 16 (9): 1034–9. PMID 23901834. doi:10.1089/jpm.2013.0014.
- ^ Tang ST, Chang WC, Chen JS, Wang HM, Shen WC, Li CY, Liao YC (2013). "Course and predictors of depressive symptoms among family caregivers of terminally ill cancer patients until their death". Psychooncology 22 (6): 1312–8. PMID 22836818. doi:10.1002/pon.3141.
- ^ Chung HM, Lyckholm LJ, Smith TJ; Lyckholm; Smith (2009). "Palliative care in BMT". Bone Marrow Transplant 43 (4): 265–73. PMID 19151797. doi:10.1038/bmt.2008.436.
- ^ "Providing Palliative Care to Family Caregivers Throughout the Bone Marrow Transplantation Trajectory". Retrieved 2014-08-21.
- ^ [1] Data from the USA 1999–2006, All Races, Both Sexes: Altekruse SF, Kosary CL, Krapcho M, et al (eds). SEER Cancer Statistics Review, 1975–2007, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2007/, based on November 2009 SEER data submission, posted to the SEER web site, 2010.
- ^ "WHO Disease and injury country estimates". World Health Organization. 2009. Retrieved Nov 11, 2009.
- ^ Horner MJ, Ries LAG, Krapcho M, Neyman N, et al. (eds). "SEER Cancer Statistics Review, 1975–2006". Surveillance Epidemiology and End Results (SEER). Bethesda, MD: National Cancer Institute. Retrieved 3 November 2009.
Table 1.4: Age-Adjusted SEER Incidence and U.S. Death Rates and 5-Year Relative Survival Rates By Primary Cancer Site, Sex and Time Period
- ^ Tran H, Nourse J, Hall S, Green M, Griffiths L, Gandhi MK (Sep 2008). "Immunodeficiency-associated lymphomas". Blood Reviews 22 (5): 261–281. PMID 18456377. doi:10.1016/j.blre.2008.03.009.
- ^ Hellman, Samuel; Mauch, P.M. Ed. (1999). Hodgkin's Disease. Chapter 1: Lippincott Williams & Wilkins. p. 5. ISBN 0-7817-1502-4.
- ^ http://www.clinicaltrials.gov/ct2/results?term=lymphoma
- ^ "Understanding Clinical Trials for Blood Cancers" (PDF). The Leukemia & Lymphoma Society. Leukemia and Lymphoma Society. Retrieved 19 May 2010.
- ^ a b Musilova K, Mraz M (26 December 2014). "MicroRNAs in B cell lymphomas: How a complex biology gets more complex.". Leukemia. PMID 25541152. doi:10.1038/leu.2014.351.
External links


text:
You are here
Australia: Shares slump as bets rise on Sept Fed rate hike; NZ lower
[SYDNEY] Australian shares slumped on Monday, dragged down by financials and materials, as investors were rattled by talk that Federal Reserve might hike US interest rates next week.
Boston Fed President Eric Rosengren said on Friday that gradual interest rate increases might be in order with the US economy at full employment and that low interest rates were increasing the chance of an overheated economy. "Eric Rosengren is a noted dove and when he came out and spoke about raising interest rates, he set the tone for the US markets... the Asian markets followed suit," said Tony Farnham, an economist with Patersons Securities.
The S&P/ASX 200 index fell 120.58 points, or 2.3 per cent, to 5,218.6 by 0241 GMT, its lowest since July.
The Bank of Japan is considering ways to steepen the Japanese yield curve, according to sources, while media reports speculating that central banks are running short of fresh stimulus measures slackened risk appetite globally.
Locally, Reserve Bank of Australia Assistant Governor Chris Kent is due to give a speech on Tuesday and there will be jobs data on Thursday.
Your feedback is important to us
Tell us what you think. Email us at firstname.lastname@example.com
Oil prices in Asia extended Friday's 4 per cent fall after rig count showed increasing oil drilling activity in the United States, indicating that producers can operate profitably around current levels.
Basic materials and energy stocks slid on the back of a strong dollar.
Mining giants BHP Billiton Ltd and Rio Tinto Ltd shed 3.5 per cent and 2.1 per cent respectively. Fortescue Metals was down 3.3 per cent.
Gold stocks were among the biggest losers in the sector after spot gold slipped 0.2 per cent by 0228 GMT. Newcrest Mining was 4.2 per cent lower and Northern Star Resources down 4 per cent.
Energy stocks fell to their lowest in over two months as oil prices tumbled. Woodside Petroleum and Oil Search lost more than 3 per cent. Santos Ltd fell 5 per cent to its lowest in five months.
The "Big Four" banks declined between 1.4 per cent to 2.3 per cent.
New Zealand's benchmark S&P/NZX 50 index, which lost nearly 1 per cent on Friday, fell 2.6 per cent, or 195.07 points to its lowest in over a month at 7,273.53.
Financials, utilities and industrials dragged the index down.
Air New Zealand Ltd was among the big losers on the benchmark, down 4.4 per cent, while accounting software developer Xero Ltd lost the most at 4.5 per cent lower.
BT is now on Telegram!
For daily updates on weekdays and specially selected content for the weekend. Subscribe to t.me/BizTimes


text:
Well another year is upon us here at DeerMichigan.com and that means another year of gear reviews and top 10 lists. We can always count on the members of the deer hunting community to share their opinions and experiences with deer hunting gear in order to help the rest of us find hot new products and old standbys that deserve our attention.
You will find everything from the best deer hunting knife to the best hunting socks, best binoculars for deer hunting and more.
Let's face it, We live in the age of the internet where deer hunting information is seeping from every corner of the country, some good, some not so good.
The good news is that the search engines are getting better and better at weeding out the bad information and showing us the good.
A simple Google search will reveal the best deer hunting information available today and here at DeerMichigan.com, we strive to provide the best information and as a result, our goal is to appear at the top of the search engines so that our readership can grow and we can help as many deer hunters as possible.
Remember the good old days when we used to head on down to the local sport shop and look at the deer hunting gear.
You could pick up each deer hunting knife and feel it in your hands. You could examine the blade for sturdiness and sharpness and you could do this for each deer hunting knife in the case.
I will say, that my local sport shop was owned by an older gentleman that always had an opinion as to what was the best deer hunting knife. I guess because I was younger, I respected and trusted his opinion and usually bought the deer hunting knife he recommended.
Well today, that shopkeeper exists on the internet and deer hunters everywhere seem to respect and trust their opinions and buy the best deer hunting knife that they recommend.
A lot has changed in my lifetime and with any luck I will see a lot more change, but one thing rings true. Deer hunters will always place a lot of trust and respect in other deer hunters opinions of the gear they use.


text:
Childhood Cancer Thrivership Symposium
Childhood Cancer Thrivership Symposium
Marina Village Conference Center
1936 Quivira Way
San Diego, CA 92109United States
Event Description:
This is a FREE educational event to learn strategies for navigating life after a childhood cancer diagnosis. You'll hear from experts at The Seany Foundation and The Leukemia and Lymphoma Society. Breakfast and lunch will be provided. Childcare will be available as well.
Click here for the day's agenda. To pre-register, click here.


text:
I am always on the look out for a bargain and if you are still considering attending TechED North America or you have just not got around to registering, unfortunately you are too late for the $200 early bird discount, as this offer expired on the 28th February.
But there is another way of getting $200 off the cost of registration – If you are an MCP, check the "March 2010 MCP Flash" as there is a discount code in the newsletter – the newsletter specifically states "Please don't share this code with others". – hence that's why it is not in the post.
Register for TechED 2010 – New Orleans


text:
A Chinese based firm has pledged to employ more than 3000 Kenyans on the standard gauge railway commonly known as SGR. Already, Kenyan president Uhuru Kenyatta has launched the project that has been hailed as a major milestone in the country's history.
The company which will operate the ongoing construction of Kenya's first standard gauge said that they will only seek locals once they start their operation in January 2018.
Also read:Chinese loans on Kenya's SGR project to hit U$10b
The firm said that those who will mainly benefit include drivers, technicians and station operators, offering employment to those laid off by Kenya Railways when it transferred rail operation to Rift Valley Railway (RVR).
According to the Transport principal secretary Irungu Nyakera the operator will advertise the jobs in 2017 and offer contracts ahead of their operations in 2018.
Also read:Court gives construction of Kenya's SGR project fresh impetus
He added that the agreement comes after the government demanded that 80% of the jobs to be offered to the locals in a mid to ensure that they curb the rising joblessness in Kenya.
Kenya gave China another sweetheart deal through contracting a Chinese company to operate business on the SGR without public bidding.
RVR, which operates the Kenya-Uganda railway, is expected to face competition from the new railway being built with Chinese financing from Mombasa to the Ugandan border.
"They directed that the contractors for the Mombasa-Kampala section undertake operations in the interim as the two partner states build their local capacities," read an agreement signed at the summit of East African Community heads of state.
Also read:Kenya seeks additional US$ 4bn from China for SGR project
Kenya Railways expects the tracks for the Mombasa to Nairobi line to be ready next year and the rail opened for commercial traffic in January 2018. RVR, which operates the ageing narrow-gauge track, will be the biggest loser.
The Railway will give a relief to the transport industry more so the bulky transportation hence helping ease congestion on Kenyan roads.


text:
Maggie was my first dog. I had dogs growing up but she was the first one that I adopted as an adult and was solely responsible for. I saved her life and she, in turn, saved mine. The story about how I saved her life is pretty straightforward. I had been volunteering at a no-kill animal shelter in North Carolina during grad school and one day I showed up for my shift to find that we had just taken in three six-week old boxer mix females. The dog that would soon become 'Maggie' was the runt of the litter and her sisters were not letting her eat. The woman that ran the shelter told me that if I did not take Maggie home as a foster until the next adoption event, then she would certainly not make it.
We all know how this goes. That night I made three different trips to the grocery store to find something that Maggie would eat. I spent the next few days coaxing her to eat while she worked to expel three types of worms from her little body. By the time she was out of the woods, there was no way I was ever letting her go to the adoption event. We grew attached to each other quickly and the runt Maggie quickly grew to become an 80 pound mass of muscle. We became quite the team; I took her with me everywhere I went—almost daily trips to the beach, on runs around campus and to all my friends' parties.
The story about how Maggie saved my life is a little bit more complicated.
When Maggie was about six months old, I met a man who was not named John, but we'll just call him that. I had been working at a coffee shop to make ends meet in grad school and John was a coworker. I guess I was at a point in my life where I was aching for love because when John came in with promises of soulmates, eyes blazing with passion….well, I was all ears. We got into our first fight at work just a couple of weeks into our relationship because John swore that some other guy was flirting with me. When he started throwing coffee cups at my feet, splinters of porcelain flying, I should have left then. But I had never had a 'soulmate' before….maybe this is just what happened.
In short, John was jealous, had substance abuse issues and didn't like to take his medicine that kept his diagnosis of bipolar disorder in check. And, in short, I suppose I was just at a point in my life where I was prime for falling into an abusive relationship with this man. In the span of two years around the time that I met John and in the beginning of our relationship, I had lost five loved ones to cancer and to car accidents. I was starving for love and comfort and when it showed up looking like a man who never wanted to leave my side, I took it.
Then the typical things started happening that tend to keep one in relationships such as this. He told me that all of my friends were stupid and shallow and he made a huge deal about having to hang out with them. So rather than rock the boat, I stopped hanging out with them. He told me that I talked to my parents way too much….so I cut that down as well. I became isolated into a world that just consisted of me and John. And then there's the whole 'these are all the things that are wrong with you so no one else is ever going to want you so you better stay with me.' Yeah, I fell for it.
I lived the next couple years of my life in this little bubble, walking on eggshells, coming home straight after work so that I wouldn't get questioned about my whereabouts and protecting John to no end when it came to the others in my life. I will never forget this one incident when I had convinced him to head down to the beach for a day of hanging out with friends. Within an hour, John became completely certain that one of my friends was in love with me and that I was sending inappropriate signals to him. So he walked off. I made up a lie to my friends, saying that John's stomach was upset (because I was protecting him….and I suppose that I thought that if I ever told any of them the truth about what was happening in my life then they would surely tell me to leave him and I wasn't ready for that yet). That day, I followed John to our car and we drove home, him yelling at me the whole way and it didn't stop when we walked in the door of the house.
So, back to Maggie……when these outbursts of John's would happen she would run out into the yard or hide in the corner of a room and just shake and shake out of fear. I would just stand there and wait for the screaming to stop. Then when it had, John would usually leave the house and I would then pull Maggie onto the bed and hold her big, strong body until the shaking stopped.
This happened way too often over the course of our time together and then one day events in my life conspired to help me make a change. I had lost my job, I had met another man who was kind and gentle, and I had an invitation to move to Colorado. But there was still the matter of figuring out if I would actually have the strength to leave.
The night I told John that I no longer wanted to be with him he took a framed picture of the two of us off the wall and threw it at my feet. It was the one time that Maggie didn't run outside. She sat there, in the middle of a pool of broken glass and she stared me straight in the eyes. And I knew she was saying "it's time–let's go." And, you see, I had gotten so far into this abusive relationship that I no longer considered myself someone worth taking care of because John had taken my self worth so low. But I could look at this dog, this being whom I had promised to take care of, and I wasn't willing to put her through it any more.
By this time I had already made plans with my dad for him to drive down the next day to help me move my stuff out of the house. While he was driving, I was packing the most important things into my car while John was at work. He came home early. I told him I was leaving. He told me that I was not taking Maggie and he positioned himself between she and I. As I made a move to get her, he stepped in and shoved me against the wall and tried to get my phone out of my hand. I got away from him and ran out to my car and locked myself in and he came outside a minute later, with Maggie. He put her in his truck and drove off. I called the police, sobbing and frantic, and told them that I needed help. They showed up and I showed them the adoption paperwork that I had packed in the car, proving that I was Maggie's sole owner. John came back a few minutes later and shoved Maggie towards me and the cop followed him up to the door of our house. The last image I ever have of John is him screaming that he was going to kill me while being restrained by the cop.
My dad had not gotten to town yet so I drove to a friends house where we made a leash for Maggie out of one of her belts. My friend's phone rang….it was John. He was screaming to her that he was going to kill me. She hung up the phone and looked at me. "Is this what you've been living with?" she asked. I nodded, the relief shedding itself in my tears, the relief that I was no longer alone in this. She and I went to the hotel and she waited with me until my dad arrived. The next day, team of friends in tow, I went back to my house to get the rest of my things. John was at work but there was a hole punched into a door and all of my clothes had been left out in the rain overnight and most of my other breakable possessions had been smashed.
We drove back to West Virginia that day and I spent a month at home, regrouping, listening to voicemails from John a few times a day…some of them angry, some of them begging me to come back. I changed my number. And then I moved to Colorado, driving for three days, eyes on the rearview often, looking at Maggie's big ol' head and also at my past slowly fading from view.
Maggie loved the mountains of Colorado almost as much as she loved the beach. There were times when I would have her out on some adventure and I would just sit still for a moment to watch her run and bounce all over the trails of her new home. Sometimes, she would look back at me and I could swear she was saying 'thank you.' I would look at her, smile, and say 'no…thank you.' Because while I might not have actually died from a life of staying with John, I would undoubtedly have had my spirit completely killed by it.
A diagnosis of bone cancer came in when Maggie was 11 and I was going through another tough time. I struggled to no end with the decision to finally put her down when the pain on her face was too often and evident. But she had led a long, proud, good life. And because of her, I was sure that I now would as well. But it was time for us to part. That's why, before she passed, I got an image of her paw print tattooed on my ribcage. It's me knowing that the strength that I feel like she gave me would always be within me. It's a promise to her to continue to keep fighting for my happiness. It's my homage to the dog who will always be my soul mate.


text:
Russ Allbery wrote:
In the meantime, the patch isn't exactly something I'd want to take upstream either, but it at least addresses the most obvious problem, and more problematically I don't see a better way of addressing it other than saying "well, anyone without a system-wide ldap.conf loses." And I wouldn't be comfortable trying to defend that position.
I suppose another possible workaround specific to the NSS module (and probably the PAM module as well) would be to proactively check whether there's a system-wide ldap.conf file and fail immediately if there isn't. That leaves the problem open for other setuid uses of the LDAP libraries, but I don't expect there are a lot of those and what ones there may be are more likely to be able to use the LDAPNOINIT flag.
-- -- Howard Chu Chief Architect, Symas Corp. http://www.symas.com Director, Highland Sun http://highlandsun.com/hyc OpenLDAP Core Team http://www.openldap.org/project/


text:
I have been involved with the Kamloops Arts Council for over five years. I began volunteering with events, and quickly moved up the ladder by helping out as a Board Director and Vice President. I was also hired as an Events and Administrative Assistant where I aided with various festivals and events, such as the well known Art in the Park on Canada Day. For about two years, I held the position as the Galleries Coordinator, where I managed two public art galleries for local, emerging artists as well as pop up exhibitions.
My favourite part about working with the Kamloops Arts Council in any capacity, has been having the ability to create social change and to allow the arts in our community to be accessible for all. It is amazing to hear about an artist's excitement as he or she hangs a solo art exhibition. And talk about the happiness of winning an award at the annual Art Exposed exhibition, I can only imagine the jitters one would have.
The Kamloops Arts Council (KAC) is a registered charitable organization that is devoted to the development and enhancement of the arts in the Kamloops area. Now in their 47th year (founded 1968), they support all artists and art organizations and promote cooperation among them, government and business. They provide local artists and arts groups – visual artists, musicians, dancers and actors – with opportunities for exposure, networking and professional development.
Lorel Sternig, Events and Programs Manager, was a pleasure to work with among others at the KAC. A local artist, Wendy Weseen, also had some kind words about her interactions with the Kamloops Arts Council's Main Gallery.


text:
Khloe Kardashian decided to copy Beyoncé's pre-Met Gala pose in her latest Instagram photos.
The 30-year-old reality star posed with her arms stretched above her head while leaning against a pillar. It was more than a little reminiscent of the photos that Beyoncé's shared before the Met Gala on May 4.
Beyoncé's Instagram photo that Khloe Kardashian shared on May 5, 2015, with the caption "I just got my motivation for the year!! Holy moly!! Yes!!!! I see you!!!! Shut it down…"
Khloe Kardashian wearing Christian Louboutin snake print and PVC heels
Shared by Khloe Kardashian on May 13, 2015, with the caption "Well @jenatkinhair and @joycebonelli thought I looked sad in the last picture so here's a new one of me casually looking off waiting for my picture to be taken lol. I'm loving my glam today ladies!!!"
Do you think Queen Bey will be happy to find out that the reality star is copying her poses? You can check out her Met Gala outfit in more detail at Your Next Dress.
To copy her favorite superstar and idol, Khloe flaunted her cleavage in a simple grey tank top knotted at the waist. She paired it with a a tight grey pencil skirt and a pair of Christian Louboutin snake print and PVC heels. While her shoes are not available online, you can find similar snake pumps from the same designer at Net-A-Porter.
'Cloo' 100 Studded Snake, PVC and Leather Slingback Pumps, $1,175
'Décolleté' 100 Painted Python Pumps, $1,395
'Décolleté' 100 Snake Pumps, $1,395
'Mayerling' 100 Leather and Python Sandals, $1,445
'So Kate' 120 Python Pumps, $1,495
'So Kate' 120 Watersnake Pumps, $1,195
Credit: Khloe Kardashian Instagram


text:
Among the good things about Instagram there is the fact that it helps me to discover new amazing foods and food photographers/bloggers. Besides my daily supply of pictures of French Bulldogs (I have an obsession here, yes). One thing I learned on Instagram was what aquafaba is. I had stumbled upon beautiful pictures of buttercream cakes that I just couldn't believe they were vegan. How did the bakers achieve such a texture in their buttercream? The answer was aquafaba.
Some googling after I learned that aquafaba is the water one usually drains when using canned chickpeas – the water the chickpeas have been cooked and preserved in. Aquafaba is extremely rich in protein, from the chickpeas, and can substitute eggs in making meringue. Those cakes had a vegan meringue buttercream and the concept of vegan meringue became my own personal challenge.The first time I decided to give aquafaba a try was not a great success. I had saved the chickpea water after making hummus for the sake of experimenting and followed a blog that instructed to reduce the chickpea water without giving enough directions really, just hinting that it would thicken. After simmering and simmering that liquid was never really thickening and in the end it almost evaporated all and I had nothing left to whip. I just gave up. Months after I stumbled upon another aquafaba recipe, and read that the chickpea water is actually ready to whip and can be used without any prior reducing. Now, I'm no expert and I just wanted to follow easy directions so I saved some chickpea water again and tried again.
Guess what? After an initial moment of doubt the chickpea water mixed at high speed actually started to froth and whipped! It was really behaving like egg whites! I was so positively surprised that I decided that I would make meringues this time!Vegan meringue:
- 30 g whipped aquafaba
- 170 g powdered sugar
- 1 tbsp vanilla extract
Since I had no idea that the chickpea water trick would actually work, I whipped it all before deciding to try making meringues. This is why I'm referring to the weight of the whipped aquafaba. I figured I'd start with a small portion – all the water from a can of chickpeas yields a lot more! So I basically transfered a part of the whipped aquafaba into another container and kept whisking it at medium-high speed adding the powdered sugar little by little. I kept adding sugar as I wanted it to stiffen, but kept tasting it in the process because I was curious to see how hard it was to get rid of the chickpea taste. The taste of sugar becomes quite overwhelming at some point, but I think that adding 1 tbsp of vanilla extract was also a good idea. Tasting the end product one can hardly guess they're not made with egg whites.The uncooked meringue has the same looks and feel of egg-based traditional meringue. Fill a pastry bag with it and pipe it through a star-shaped tip. Bake the meringues at 100°C keeping a wooden spoon in the door of the oven so that it doesn't close completely. Depending on the size of your meringues the cooking time varies – if you go with small stars like I did it will take around 2 hours. More than actual baking, it is a slow drying process, really.
So… success! Chickpea water-based meringue worked! Now vegan Swiss meringue buttercream will be the next challenge.


text:
Two Kids' Social Networking Sites Reported to Feds for Privacy Problems
The Children's Advertising Review Unit of the Council of Better Business Bureaus (CARU) referred the owner to the FTC after it failed to participate in a review of the privacy practices of its sites, FBFkids.com, and FBFkiddies.com, the group announced in a press release.CARU monitors websites for compliance with its Self-Regulatory Program for Children's Advertising, including guidelines for online privacy protection, as well as with the federal Children's Online Privacy Protection Act (COPPA).
After an initial review, CARU found FBFkids.com and FBFkiddies.com, which promote themselves as sites for children under 13, allow visitors to create user profiles, play games, chat with other members in real time, and post pictures and videos. To register, visitors must enter a username, email address and password.
When CARU initially reviewed FBFkids.com, the group said, the site did not display a privacy policy. Further, in the site's chat rooms and profiles, children were able to enter personally identifiable information (PII) including their full names and telephone numbers.
Both CARU's guidelines and COPPA, the group says, require website operators to obtain verifiable parental consent prior to collecting personally identifiable information such as email addresses or allowing children to participate in chat rooms where they can post revealing information.
When contacted by CARU, the site's operator failed to provide a "substantive written response," which triggered a request for review by the FTC.
FBFkids.com failed to respond to Consumer Ally requests for comment.
The site, which says on its homepage "is NOT Associated with Facebook, Myspace or facebook for kids," (sic) also gives no indication of ownership or location beyond the following statement:(which appears here un-edited)
When Consumer Ally examined the site, links to the privacy and safety and terms and conditions pages from the the site's "About" page were dead. However, separate links to the privacy and terms page did take users to live pages.
We are a family just like yourselves. I am a Mother of 2 (Mother Hen) My oldest son is 20 and very heavily into computers and on site videos and games My youngest son is just approaching 5 and is just starting to surf My Husband Studied Computer Science at The University of Weston Ontario I am originally Dutch, as is my oldest son. My Youngest son was born in Spain and My Husband is English having lived in Canada, and America. I speak 4 Languages (Dutch, German, Spanish, and English) and we all now live in in the UK.
CARU spokeswoman Linda Bean said site operators sometimes make changes to their websites after being contacted by her group, but added such efforts still fall short.
"They may look at the list of concerns and address them in some fashion, but the requirement is still for a substantial written response," Bean said.
The National Advertising Review Council (NARC) establishes the policies and procedures for the National Advertising Division (NAD) of the Council of Better Business Bureaus, the CBBB's Children's Advertising Review Unit (CARU), the National Advertising Review Board (NARB) and the Electronic Retailing Self-Regulation Program (ERSP).
In February, the NARB advised Time Warner to pull ads claiming its telecommunications services are carried on a fully fiber-optic network.


text:
Eugene Domingo bares her heart
Eugene Domingo is on a roll. Despite having bagged a number of acting awards, Uge's not one to sit on her laurels. I love how she outdoes herself in every movie she makes.
The People's Choice Best Actress at the Asian Awards bares her heart in this tete-a-tete. Kudos, Uge! Passion is truly in everything you do. If only you could be cloned, because the industry is in dire need of more actors like you!
How has winning the Asian Awards changed you and your perception of your craft?
That beautiful moment when I won came at the right time. I am more secure about my job, and the most important thing for me now is to give hope and inspiration to everybody who needs it. I prayed that I would bring back something not only for myself but for all Filipinos who continue to believe in what artists can do. I feel more selfless and have a genuine concern on how I can possibly help upgrade the industry in my own unique and small way.
Are good thespians like you born and not made?
Everybody has a gift. Some are developed. But the truly gifted are born with it. But they should never take it for granted. Acting workshops can help, but practice and exposure and training constitute the real deal.
Your background in theater has helped you a lot. How is acting on stage different from acting in film? Which is more challenging?
Both are equally challenging. The stage is an actor's medium while film is a director's medium. I find fulfillment in both. I am challenged both by the proper way of moving onstage and how to act in front of the camera. I constantly refine my techniques.
I find it sad that theater actors here are not paid as much as movie stars. What do you think should be done to make stage plays more marketable especially for the masses?
Oh, good question! I'd like to share with you the good news! I am doing a play with PETA. We will do the stage version of Lino Brocka's "Bona." The rights to this film are owned by Nora Aunor and I am forever grateful for her trust, support and love. She has signed already, so tuloy na tuloy na! I will be with a very hot actor now whom I sense is very serious about his craft! I am very excited! Popular actors should bring themselves to perform onstage so their followers will have a chance to see them live in action. This will arouse curiosity and eventually attract more people to watch theater productions.
What is the most important lesson you've learned so far?
It doesn't stop with being gifted. You have to share your gift. No one is more amazing than God and you can never imagine the greatness of His plan.
If there's something you could change in the local movie industry, what would it be? And how do you suggest it be done?
The number of working hours! I hope actors, especially the veterans and the bigger stars, unite to implement a maximum number of working hours for everybody. We are only human, after all. Fortunately, I have a "cutoff," not because I want to be stariray but because my brain shuts down after
10 p.m.! I am a day person.
Any roles you still want to portray?
None in particular. Although it thrills me to learn a new dialect or language. In "Kimmy Dora and the Temple of Kiyeme," I had to learn Korean!
What is your guilty pleasure?
Traveling extravagantly!
What are you not good at?
Math and Natural Sciences.
What's the naughtiest thing you've done?
Being super pa-close with Andy Lau onstage. But when we were backstage at the Asian Film Awards, I said to him, "Thank you, sir!" He smiled.
What's the most embarrassing moment you've had?
Why is it difficult to think of this right now? Makapal na yata mukha ko talaga!
What's love to you at this point in your life?
Learning to love yourself is the greatest gift of all. Because if you love yourself, you won't harm your body nor destroy your spirit. Stay in touch with what's really important and surround yourself with those who genuinely love you.
Do you still yearn for a lifetime partner or are you happy being a woman at the top of her game?
I'm in a good place right now. To yearn for more is to overlook what God has designed for me.
Have you ever been rejected? How did you handle it?
I am a person who can easily move on because I can laugh at myself! I feel frustrated at times, but that's human nature and I don't let it discourage me. I pray often.
If you were not an actress what would you be?
A bank teller!
What's the hardest part of being Eugene Domingo?
I work hard and expect the same from my team. So when I'm taken for granted, or people don't listen, I lose my trust and that breaks my heart.
What's the best part of being Eugene Domingo?
My honesty.
How would you like to be remembered?
As the people's actress who has opened doors to many possibilities and shared her victory. Wow! Dami pang kakaining bigas. Brown ha!
For feedback, e-mail: [email protected]
Subscribe to INQUIRER PLUS to get access to The Philippine Daily Inquirer & other 70+ titles, share up to 5 gadgets, listen to the news, download as early as 4am & share articles on social media. Call 896 6000.


text:
If you like modern interior design, you're a big fan of bold edges, sharp corners, and streamlined silhouettes. The more urban, the better and you're not afraid to take things to the next level. Forget traditional turned legs and elaborately carved wood trim—you're all about simplicity. Modern furniture will always look trendy and fresh in your living space, but what about those uncommon accent pieces that look a little—well, odd?
You can use them too. Here's how to use unusual form furniture in your home and give your room that eccentric up-do it needs.
Add stepped shelving.
Everyone loves showing off his or her collectibles and knick-knacks. These items showcase your personality, so make sure you present them in a unique way. Stepped bookshelves, multi-level end tables, funky display cases called étagères and other ladder-like shelving is the perfect way to bring in unique shapes that attract your guests' eyes and decorate blank walls. Items like the Multiple Shelf End Table and Pyramid Elm Display Shelf from Furniture Row are great finds for presenting your prized possessions, picture frames, books, and more.
Use geometric shapes.
Nothing says fun like geometrics, so make sure you don't shy away from shapes. Drum end tables, hexagonal tabletops, circle motif mirrors, trellis doors, and other creative patterning or forms on your furniture is spunky, modern, and makes a statement. At Furniture Row, we love the Helix Coffee Table with its twisted metal pedestal base, the Modern Circles Accent Mirror, and Pentagon Wood Table Lamp.
Bring in beatnik vibes.
Beatnik style originated during the 1950s and lasted through the mid-1960s, and was a trend in fashion, literature, interior design, and other artistic pursuits that rebelled against proper society and sophistication. Instead of pieces with fresh paint finishes and elegant molding, choose furniture with rustic distressing and heavy metal accents. Strange shaped furnishings with a retro influence will captivate your design imagination like the Logan Elm Console.
Find items with quirky character.
Last but not least, make sure you choose those edgy pieces that cause you to take a second look at them. Furniture with a unique pattern or retro features such as splayed or metal hairpin legs like the Stanley Sideboard will look truly original in your space, and spark conversation with friends and family.
Decorating your home is a lot of fun, but don't be afraid to get creative! Unusual form furniture is all about letting go of tradition and experimenting.


text:
Shop All
Fern Wood sign
Regular price $48.00
Tax included.
Size: 12.5 inches x 12.5 inches x 1 inch thick
Background: Off White Chalk paint, hand painted black with paint pen
Frame: Medium stain wood frame
Each piece has natural imperfections such as holes and knots, and no two signs are exactly alike. Please keep in mind the color may vary depending on computer screen resolution. I do my best to photograph my signs accurately.
Attention Victoria BC shoppers: Use Coupon code SHOPLOCAL if you are local and wish to pick up your item. I will message you to arrange pick up.
Please message if you have any questions thank you!


text:
Student Download Center
From CIDI Wiki
Revision as of 14:23, 2 November 2011 by Zbeard3X (Talk | contribs) (→After entering the Student Center)
Students can pick up their electronic books from AMAC's Student Download Center online (www.amacusg.org/studentcenter.php). An email will be sent when the book is ready to be downloaded. In addition to download books, students can:
- Check the status of orders,
- Download electronic book files,
- Download assistive technology software, and
- Watch assistive technology training videos.
To Login
- Follow the link in the email to the Student Download Center
- Enter your Email and PIN (provided)
- Click Login
Downloading Books
- Click on the order by either pressing the order number or icon
- Scroll down to the Downloads section and click on Download File
- Your book will automatically begin downloading
The following videos will demonstrate how to get the most out of the Student Center:
- Tour of the AMAC Student Center (4 minutes 27 seconds)
- Quick Tour of the Student Center (2 minutes)
- Login to the AMAC Student Center (1 minute 23 seconds)
- How to download book files (2 minutes 57 seconds)
- Unzipping your book files
- Unzipping with Windows Vista (2 minutes 31 seconds)
- Unzipping with Windows XP
- Unzipping your book files
- Downloading software for reading (5 minutes)
- Instructions to check whether you have a 32-bit or 64-bit computer.
- Open System by clicking the Start button (Window logo in lower left of screen), clicking Control Panel, clicking System and Maintenance, and then clicking System.
- Under System, you can view the system type.
- Add reading software to your computer
- Download other voices to your computer
- Use the training support
- Get help


text:
Real estate speculation is a risky business. Mitigating that risk through a comprehensive understanding of pricing, market conditions and trends, zoning and land use issues, city process, and construction costs is essential. For the real estate syndication cycle to end with profitable results, acquiring the asset for the right price is not nearly as important as understanding how to run a proper cost analysis and pro forma.
There are many ways to structure syndicated or crowdfunded real estate deals and partnerships. There's donation based, debt, equity participations, and crowdfunding opportunities. Sponsors can make their money in a variety of ways and choose to offer a variety of different returns. To avoid mistakes, make sure the deal structure is well thought-out, competitive, framed, and marketed in an appealing way that your target investors will understand.
As we said, real estate speculation is risky, but that's largely from an investment standpoint. Syndication is even riskier because it adds an additional layer of liability risk – from investors and government authorities. Both investor rights attorneys and government regulators have the ability to cripple an investment syndicate and cause sponsors to incur personal liability, in some cases.
With any group investment where there are both active and passive investors, sponsors should be thinking about Regulation A, D and A+ filings and other variations. There are also state Blue Sky laws and, in California, Section 25102(f) notices and exemptions. If self-directed IRAs are being used, sponsors must think about and address ERISA issues in their offerings and private placements. This can be a really dangerous game to play if you don't know what you're doing. For that reason, having solid legal counsel with experience in these areas can help you avoid some of the major pitfalls associated with syndication and structure your ask and raise correctly.
Each round of financing requires thought and the foresight to anticipate investor questions and concerns. If you are raising too much money, you probably aren't saving enough equity for later rounds, which might cause negative dilution and a reduced profit margin for investors. If you raise too little, you have to make a capital call or open another round, which can upset investors and throw off your pro forma. Still, it is far better to have too much than to go back to your investors to ask for more cash at a later point. There can be a lot of additional costs involved in syndicating real estate deals. Especially if you don't have a solid business plan. These costs can range from legal work, research, and marketing to staffing, servicing investor clients, payment processing fees, accounting, property renovations, city fees, and more. The last thing you want after you've done all the work and raised the money is to realize those costs mean that you can't deliver on your promise to your investors.
Without the right legal documents, such as partnership agreements, operating agreements, PPMs, subscription agreements, internal policies and procedures, etc., and without ongoing general counsel, you miss the opportunity to address, in advance, problems created by external forces, including management problems, sponsor bankruptcies, investor lawsuits, and marital dissolutions. The urge may be to present to investors a more attractive pro forma by significantly reducing your budget for legal services, but that is a mistake. Mature projections always include sufficient legal budgets that account not only for initial organization, but ongoing counsel in an effort to mitigate the damage caused by such external forces.
For more information on syndicates and group investments, or the law firm of Lowenthal APC, please click here or call us at 530-298-7868.


text:
Metso Mining and Construction has announced construction of a service hub for future servicing of Grupo Mexico's Buenavista de Cobre mine. The $9-million order, according to Metso officials, will expand the mine's copper concentrate capacity by 50%.
Metso representatives said they were glad to be chosen as partners. "Our industry-leading services capabilities also greatly influenced the customer's decision," said Alejandro Castillo, a capital project sales manager at Metso. Altogether, 38 belt feeders will be installed at the mine located at Cananea in Mexico's Sonora state. Q2 2014 delivery completion, added the company, will be followed by start-up beginning in Q3.
The belt-type order comprises equipment meeting all ore-feeding challenges after the mine expansion, said the company. Five of the feeders have 1,260 metric tons per hour (mt/h) capacity; eight have a 918 mt/h capacity; another eight have a 1,590 mt/h capacity; and 16 possess a 575 mt/h capacity. The expansion targets a capacity increase of 110,000 mt/d. Afterward, the mine will process up to 200,000 mt/h of ore daily.


text:
With the complete integration of computers, mobile devices and the Internet, today's network systems are becoming more and more complex. The key is to work with a technology partner who can strategically align your company for future growth and technological advancement.
At Bennett, our highly trained sales representatives and system engineers will work with your business to assess your current and future networking and communications needs. Learn more about the IT Services Bennett Office Technologies provides:


text:
Finding useful health information on the Internet can be difficult, but we're here to help. This page gathers quality information from trusted sources. You can learn more about the disease, visit handpicked websites, and find resources to help you in your daily life. Need more information? Click the menu on the left to find more!
Medical Disclaimer
The medical information on this site is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment.
Varicella zoster virus
Varicella zoster virus (VZV) is a herpes virus that causes the chicken pox in children and shingles in adults. VZV first enters the body either through the respiratory tract or the eyes, and later infects the nervous system. Symptoms of fever and general discomfort are noticed between 10-21 days after initial exposure to the virus. A characteristic rash with red, spotted lesions will then appear in several stages, often spreading from the head downwards to the arms and legs. The rash will be more severe when seen in adults than in children.
Symptoms are most common in the winter and early spring. The disease may be spread through the air or by direct contact with infected individuals at any time until their rash has dried into crusted lesions. After symptoms clear, VZV remains inactive (latent) in nerves and results in lifetime immunity for most people. Reactivation later in life results in shingles (herpes zoster), which occurs in 50% of people by age 85. Shingles is most common in the elderly with weakened immune systems and who were exposed to VZV either while in the womb or at less than 18 months of age.
Complications occur most commonly in individuals younger than 1 year or older than 15 years of age, and in those with weakened immune systems due to other health problems. Complications are often caused by bacterial or viral infection of the skin lesions, especially in young children. Aseptic meningitis is the most common complication that affects the central nervous system, and will generally have mild symptoms. Encephalitis is a rarer and more serious complication that may result in seizures or coma.
Hospitalizations and complications from VZV have decreased since the introduction of the vaccine. Those affected with VZV should not take aspirin, as it may result in Reye's syndrome, a serious condition that causes brain death and liver damage. If you have been diagnosed with VZV, talk to your doctor about the current treatment options.


text:
Newsflash for those of you not smart enough to figure this out: if you attack an officer of the law, they do not have to warn you that they are going to mace or tase you.
One would think this goes without saying, and you'd think that protestors would do some research before acting like fools….Ha. Kidding. They would have to be able to read to do research.
Blue Lives Matter report:
St. Louis, MO – St. Louis activists who were protecting the acquittal of Jason Stockley are crying about being abused by the police after they blocked a police transport van and then started shoving police officers, and that's their side of the story (videos below.)
Trending: Saul Alinsky Dedicated His Book 'Rules for Radicals' to LUCIFER
The Associated Press reports that around 2:40 PM on Friday, a group of the protesters stood in front of a police transport bus full of officers in riot gear, blocking it from moving.
The bus tried to back up, but then a group stood behind the bus, blocking them in. The group then started throwing objects at the bus.
When the officers began to push them back, the crowd pushed against the officers. Bad move. That's when they were "maced by the police without any forewarning," according to one woman.
Protesters are facing off with police in riot gear in downtown St. Louis after blocking a bus filled with officers. https://t.co/mLNB815ySD pic.twitter.com/5D2guUjJ3M
— AP Central U.S. (@APCentralRegion) September 15, 2017
The views expressed in this opinion article are solely those of their author and are not necessarily either shared or endorsed by EagleRising.com


text:
August 04 2011
Confirmed: Sarah Michelle Gellar will guest on 'All My Children'. She said at the Ringer TCA panel, "I called up the casting director and told her I wanted to do something, that I want to be a part of it.".
Haven't watched that show since I lived at home with my mom.
Looks like I will be tuning in! Haha. :)
Looks like I will be tuning in! Haha. :)
Soap Opera Digest.com is reporting her airdate is September 21 and she'll share scenes with [SPOILER ALERT!]Eva LaRue's Maria Santos[END ALERT].
This thread has been closed for new comments.
You need to log in to be able to post comments.
About membership.


text:
Setting up your humidifier
Got questions about how to set up your humidifier? Find the answers to the most frequently asked questions about humidifier setup here.
Q. Can I put my device on top of the humidifier?
A. Your device should always be placed either at the same level or above the humidifier to reduce the risk of water entering the CPAP machine. To further ensure that water doesn't enter your device, disconnect the humidifier and drain the water before transporting it.
Q. I have a full face mask. Will I need more water during the night?
A. A full face mask should not change the amount of water used each night. If you had a mouth leak before, you could have been losing air and humidity through your mouth, in which case you should use less water now.
Q. Does heated humidification wear out my mask and hoses faster?
A. No. The tubing supplied with devices can withstand far higher temperatures than the heat generated by the humidifier.
Q. Should I turn on my humidifier before I go to bed to make sure the water is warm first?
A. If you find the air dry and irritating, you may want to turn your humidifier on 20 minutes before going to bed.
Q. I usually use my humidifier only in the winter months when the heater is on and the air is drier. Should I be using it all year round?
A. If you're finding that you have nasal symptoms at other times of the year, then you should probably use your humidifier. The added humidification will most likely increase the air comfort since it's more fully moisturized.
Q. Is humidification helpful for upper respiratory resistance syndrome (UARS)?
A. Unfortunately, there's no evidence to show that humidification helps with UARS; it does, however, help alleviate side effects caused by the device. If you're on therapy and experiencing nasal dryness/symptoms, then humidification should help decrease the symptoms, which are generally caused by the increased flow of air through your nasal passages. Humidification adds moisture, helping you cope with the increased flow of air.
Q. If I run out of distilled water, is it OK to use tap water once in a while?
A. Using distilled water will maximize the life of the water tub and reduce mineral deposits. Therefore, we recommend always using distilled water for use with therapy.
Do you have a question about setting up your humidifier that isn't addressed here? Contact ResMed customer support at 1 (800) 424-0737, or click here to submit an online inquiry.


text:
This is an immediate opening for a full time (5 days/week) staff position at our Vancouver office (subject to public health recommendations).
Application Deadline: July 31, 2020
West Coast Environmental Law harnesses the power of law to solve complex environmental challenges. For over 40 years we have provided legal information, advice and support to British Columbians in every corner of the province seeking to protect their water, lands and air, while working at the provincial and national scale for systemic legal solutions to environmental problems.


text:
Resistance and tolerance mechanisms play role in cancer as well as infections
In addition to demonstrating that cancer kills flies in dose dependent manner, just as bacteria and viruses cause infections in dose dependent manner, scientists established a system for disentangling resistance and tolerance mechanisms to cancer in a Drosophila model.
A Stanford University lab whose studies have advanced scientific understanding of resistance and tolerance defense mechanisms to bacterial and viral pathogens has now turned its sights on cancer.
"Just as there are resistance and tolerance mechanisms that target invading microbes, we predicted that there are also resistance and tolerance mechanisms that control a host's response to cancer," David Schneider, Ph.D., who heads the lab, and postdoctoral researcher Adler R. Dillman, Ph.D., wrote in their GSA Drosophila Research Conference abstract.
While resistance refers to an organism's ability to rid itself of pathogens, tolerance describes the ability to limit disease severity.
To apply the concepts of resistance and disease tolerance to cancer, Drs. Schneinder and Dillman injected adult Drosophila melanogaster flies with varying doses of fly neoplastic cancer cells containing the Ras gene mutation, one of the most common gene mutations in human cancer. The results enabled the scientists to establish the dose response curve of the fly to the mutation.
They screened over 200 different RNA mediated interference (RNAi) lines targeting immune signaling pathways, metabolism and signal transduction. RNAi inhbits gene expression by triggering the destruction of messenger RNA (mRNA). This genetic screen is ongoing.
In addition to demonstrating that cancer kills flies in a dose dependent manner, just as bacteria and viruses cause infections in a dose dependent manner, Drs. Schneider and Dillman established a system for disentangling the resistance and tolerance mechanisms to cancer in the Drosophila model.


text:
About US
About US
Here at CDL Legal we are passionate about the trucking industry. Trucking is the backbone of our economy and we are here to protect it. Increased regulation has made it more difficult for drivers and carriers. Our desire is to keep drivers driving by helping drivers and carriers proactively protect themselves legally. Driver shortage continues to get worse, it is important for us to fight back and give drivers more comfort in having their CDL's protected. Our management team has almost 30 years of combined experience in transportation and fighting tickets.
Discounts / Rewards
Local Attorneys
We work to find a local attorney in the area your citation was received. Our attorneys have a 95% success rate.
CSA Violation
Upon receiving a moving or non-moving violation, we provide a local attorney – familiar with the judge and local laws – to take the case.