text:
Swiss Re Corporate Solutions Ltd. and Veolia have joined forces, under the auspices of The Rockefeller Foundation, to launch an infrastructure recovery initiative to speed up economic recovery in the aftermath of catastrophic events for cities across the globe.
The partnership, designed to support cities worldwide in the areas of climate change adaptation, disaster risk reduction, infrastructure enhancement and recovery, was announced in Davos, Switzerland at the World Economic Forum, by Swiss Re Corporate Solutions CEO, Agostino Galvagni; Antoine Frérot, chairman and CEO of Veolia, and Rockefeller Foundation president, Dr. Judith Rodin.
The current reality is that cities rarely have financial plans in place to protect critical assets against shocks before they occur, and in the aftermath of such events, cities must determine what is damaged, how it will be fixed, who can fix it and how to fund these repairs, which can take months or years, said a statement issued by the three organizations.
This initiative is designed "to dramatically improve and streamline the existing process," the statement said.
Under the partnership agreement, Swiss Re and Veolia, which is a resource management company with expertise in water, energy and waste systems, will work with cities to understand the risk exposure of critical assets under current and future climate scenarios.
Under this agreement, both partners will perform risk assessments of cities, identify their most vulnerable and valuable assets, and work together to build resilience strategies around these assets, the organizations said, noting that these assessments could help cities develop resilience plans while reducing their risk exposure over time, the statement said.
Swiss Re and Veolia said they will work to develop a pilot for the initiative in a city, such as New Orleans, which could focus on some of the city's infrastructure, including critical water and wastewater systems.
By planning ahead for major shocks and stresses, cities not only strengthen the resistance of their vital infrastructure, they can also limit economic interruption and begin to quickly repair damage without waiting for insurance assessments, payouts, and solicitations for repair proposals, the statement continued.
The partnership was brokered by 100 Resilient Cities (100RC), a Rockefeller Foundation funded initiative, aimed at helping cities better understand the susceptibility of their critical infrastructure to disaster risk, provide the resources to better protect this infrastructure, and enable these assets to be more quickly functional following a disaster.
"When we joined the 100 Resilient Cities project as one of its founding partners in 2013, part of the commitment was to create a functional toolbox for cities to assess, price, prepare for and mitigate risks. Our partnership with Veolia brings us one step closer to fulfilling that vision, and we're convinced that if we can make it a success, the concept can be scaled and replicated for other cities, and for other services. It's an important step in moving resilience from talk to action," said Agostino Galvagni, CEO Swiss Re Corporate Solutions.
"We support the initiative as we hope our expertise in risk management is central to building cities that are more resilient by helping them to identify, quantify, prioritize and ultimately transfer this risk away from their citizens and into the private market," said a Swiss Re spokesperson.
"This partnership is a sign that the private sector better understands what cities need to build resilience, and cities will no longer have to make difficult and often inefficient decisions after experiencing a disaster. They will know what is at risk, how it needs to improve, who will fix it, and where the funds will come from, all which allows them to rebound more quickly," said Michael Berkowitz, president of 100 Resilient Cities. "Hopefully, this is the just the beginning, and when other market leaders recognize the importance of what Swiss Re and Veolia are doing, they too will begin to really innovate."
"Our partnership with Swiss Re embodies the fact that resilience goes much beyond risk prevention and recovery in case of natural disaster, said Antoine Frérot, chairman and CEO of Veolia. "We are strongly convinced that resilience reinforces cities' attractiveness and represents a competitive advantage for cities."
"Through the combination of their expertise, this initiative will help cities identify both vulnerabilities and opportunities, and pave the way for enhanced resilience. Investments in resilience-building ensure that the very fabric of our communities remains strong, in good times and bad," said Dr. Judith Rodin, president of The Rockefeller Foundation.
About Veolia and The Rockefeller Foundation
Veolia designs and provides water, waste and energy management solutions that contribute to the sustainable development of communities and industries. With more than 179,000 employees worldwide, the group helps to develop access to resources, preserve available resources, and to replenish them.
The Rockefeller Foundation's mission for more than 100 years has been to promote the well-being of humanity throughout the world. The foundation works at the intersection of four focus areas – advance health, revalue ecosystems, secure livelihoods, and transform cities — to address the root causes of emerging challenges and create systemic change.
- Manmade Threats Growing (published in Carrier Management, Insurance Journal's sister publication)
- Lloyd's: Cities Hurt More by Market Crashes Than Natural Disasters
- Lloyd's City New Risk Index Aims to Raise Awareness of Systemic Risks Facing Major Global Cities (published in Carrier Management)
- Focusing on Disaster Costs Before Rather Than After They Happen
- U.S., Rockefeller $100M Fund Promotes Natural Disaster Mitigation, Insurance for Poor
- In Search of Scientific, Engineering Solutions to Make Cities Resilient
- 10 Ideas Chosen for Coastal Shields in New York, New Jersey
Was this article valuable?
Here are more articles you may enjoy.


text:
Earlier this morning, Ottawa's Mayor Jim Watson joined Co-Chair Jeff Westeinde and local entrepreneurs to officially open Invest Ottawa, the flagship of the City's $5.5-million annual economic development strategy. Invest Ottawa, which replaces the Ottawa Centre for Regional Innovation (OCRI), will foster start-up enterprises, attract new investment, and help existing businesses located in Ottawa expand beyond our borders.
"One of my priorities in this mandate was to establish Invest Ottawa to help attract more investment and foster greater economic growth in our nation's capital," said Mayor Jim Watson. "Recent headlines surrounding public service job losses underscore the need to diversify our local economy, and Invest Ottawa is going to help us do just that. Invest Ottawa is a clear commitment to inspire more entrepreneurs to build our prosperity to meet the challenges of today and tomorrow."
"I feel like Ottawa has a renewed interest in growing exciting businesses again," said Bruce Lazenby, Invest Ottawa's President and CEO. "We are now providing incubation services for startups, rapidly forming effective collaborations between the city's economic stakeholders to increase entrepreneurial activity, and hiring sector-specific business development executives tasked with measurable growth goals."
According to Statistics Canada jobs report stated the region added more than 8,300 jobs in January and more than 20,000 jobs over the past year. This pushed the Ottawa and area's jobless rate down to 5.9 per cent, well below the national figure of 7.6 per cent.

subset: commoncrawl


text:
| 11.5°C Belfast
Fireworks in a French Riviera resort town appear to have prompted a panic that led to dozens of injuries as people scrambled to flee, authorities said.
Residents are on edge around the country after a string of deadly attacks, including the Bastille Day truck rampage in Nice last month that killed 85 people after a fireworks show.
About 20 kilometres (12 miles) down the coast from Nice, loud sounds that apparently came from small-scale fireworks sent restaurant-goers fleeing in alarm.
About 40 people were injured in the melee, the local administration reported.
Nice-Matin newspaper quoted witnesses who described confusion and fears of a new attack.
France has been under a state of emergency since Islamic extremist attacks in November killed 130 people.


text:
The Ingram School of Nursing at McGill University offers two streams of study at the undergraduate level - one leading to a Bachelor of Science in Nursing (for graduates with college-level preparation in the health care sciences) and the other to a Bachelor of Nursing (for students with a Quebec diploma in nursing).
At the graduate level, the School offers a distinctive three-year program leading to a Master of Science degree in Nursing that is specifically tailored to graduates with Arts or Science degrees and no previous preparation in nursing. This is the only program of its kind in Canada.
For more information on each of the programs offered, please use the vertical navigation bar on the left.
For information on application fees and other charges, visit the Student Accounts website.


text:
Russian Airline Will Give $160,000 to the Person Who Writes Its New Jingle
UPDATE: Sept. 8, 2014 A spokeswoman has confirmed to Mashable that the contest has been called off.
"Aeroflot has decided to cancel the open request for proposals process for the musical composition," the spokeswoman said.
Russia's state-run airline Aeroflot is offering big bucks for a new English-language jingle.
A request for proposals details what the airline is looking for, offering 5.8 million Russian rubles — just a bit less than $160,000 — for the winning composition.
See also: 30 Songs to Fuel Your Summer Vacation
The song must include the word "Aeroflot," must not include profanity, must be catchy and completely original, should have three verses and three choruses, and must not mention other brands. A Russian translation is also required.
In addition to the instrumental song, Aeroflot is asking for a lounge version and a Eurodance/dance-pop version that is energetic and upbeat. (So Aeroflot can be all up in the club.)
Aeroflot also lists several reference songs for what kind of tunes the airline is expecting. Among them are Adele's "Rolling in the Deep," Amy Winehouse's "Rehab," Fun.'s "We Are Young," Coldplay's "Viva La Vida," Kelly Clarkson's "Stronger" and Carly Rae Jepsen's "Call Me Maybe." Clearly, the airline has set the bar high.
The detailed proposal is available here in Russian.
This isn't the first time Aeroflot has looked to attract top talent for its marketing materials, reports Harriet Baskas:
"Many airlines use music as part of their branding and this isn't the first time Aeroflot is creating a Western-style jingle," said Cameron Fleming, a New York-based advertising copywriter and associate creative director who describes — and shares audio — from two 1960s-era Aeroflot songs on his blog, Fly the Branded Skies.
"They had some serous talent working on those songs," said Fleming. "The composers were award-winning at the time and one of the singers was Eduard Khil, who later became the viral Internet sensation, Mr. Trololo."
The 1969 song "Aeroflot" (audio available at the link) included the lyrics, translated for Fleming from Russian by Olga Vladova:
Hurry, we all hurry. And what if it rains? Please don't tell me, "the flight will be cancelled." We fly above clouds, we're not afraid of bad weather. That's our Aeroflot.
What if winter comes? And it snows and gets icy. Please don't tell me, "the flight will be cancelled." Even in winter, you should know that planes will never fail you. That's our Aeroflot.
Aeroflot has five current songs on its website, all in Russian. The best one is here.
Airline jingles and slogans have a long history, from "Fly the Friendly Skies" to ""There's No Better Way to Fly," and it's worth taking a listen to some of the classic compositions for inspiration:
Applications will be accepted until Sept. 24. The winner will be announced Oct. 9 and the final jingle should be finished Dec. 15, according to The Moscow Times.
Sadly, the requirements of the proposal prohibit sharing the original compositions online, so we may never know what catchy tunes failed to win over Aeroflot officials.


text:
Amy Muhlendorf has more than 15 years of experience as an attorney focused on employment law. She started her legal career in a large law firm and has held multiple in-house counsel positions, focused on employment law for government contracting and financial services firms. In addition, she broadened her experience by serving as Vice President of Human Resources for a government contracting company with more than 5000 employees, including many working overseas in austere environments.
The combination of her experience allows her to provide practical and business-oriented advice to executives and managers on issues related to all aspects of the employer-employee relationship. Her specific strengths include preparing policies, procedures, and handbooks that are both legally complaint and easy for employees to understand, advising on issues related to federal and state employment laws, such as Title VII of the Civil Rights Acts of 1964, the Americans with Disabilities Act, and the Fair Labor Standards Act, and creating solutions to complex employee-related matters. She has performed many investigations into allegations of harassment, discrimination, and other violations of law or policy and has successfully defended employers in administrative claims and litigation matters. Amy also develops and delivers employment law and compliance related training to employees at all levels, including current and aspiring managers.
Amy received her J.D. from American University, where she was the Executive Editor of the American University International Law Review. She also received a Master's degree in Educational Leadership from the University of Delaware and a Bachelor's degree from the University of Hartford.


text:
When I received the Kinzd Minimalist Wallet Unique Thin Men's Front Pocket Wallet Small Credit Card Holder it made me think of a wrist band. It is that small.
Small sometimes is good, and it is in this instance. It can hold 8 – 10 credit cards, paper money, coins, and has the ring for your keys. If you are popping to the store, or at the gym, this is a perfect size to carry. It can be slipped into a pocket, purse, fanny pack, and will barely take any space.
It is really well made, and the elastic holds the cards, so that you have no fear of them coming out. I turned mine upside down, shook it, and they stayed in place.
Have a Dad that loves to pay golf, then this would be a great Father's day present for him. It won't break the bank, at just $7.99, and free shipping if you have Amazon Prime.
Check out my YouTube video, as that will prove to you, how neat this product is.
I did receive this item for free, and am so fascinated with it, I just had to share it with you.
kinzd Slim Wallet RFID Front Pocket Wallet Minimalist Secure Thin Credit Card Holder
kinzd Money Clip, Front Pocket Wallet, Leather RFID Blocking with a Strong Magnet.


text:
July 12, 2017 from 5pm to 8pm – Cycle Gear Cycle Gear - Lawrenceville, GA Bike Night Every 2nd Wednesday of Each Month! Music & Cool Vehicles Cycle Gear Lawrenceville, GA 722 Collins Hill Rd (678) 225-0131 Store Hours: Mon-Thu: 1… Organized by Cycle Gear | Type: bike-night, motorcycles
July 12, 2017 from 7pm to 10pm – Pizza Shack Everyone please come out to the Pizza Shack in Dallas, GA for bike night, sponsored by Southern Devil Harley-Davidson. If you have any questions please call 678-721-0203 or email us at jsheppard@sout… Organized by Southern Devil Harley-Davidson | Type: bike, night
July 12, 2017 from 7pm to 10pm – Atkins Park Restaurant Come out to Atkins Park for Hellbender's Bike Night. You will have a chance to Register To Win a Harley-Davidson Motorcycle! We will have a bike night at Atkins Park every second Wednesday of the mon… Organized by Hellbender Harley-Davidson | Type: bike, night
July 12, 2017 from 8pm to 11:45pm – TGI Friday's Camp Creek Come Out Each and Every Wed Night to the "LARGEST WEEKDAY BIKE NIGHT IN THE SOUTHEAST" at TGI Friday's Camp Creek Location. Vendors, Giveaways, Music, Plenty of Parking, and Much, Much More. Organized by John '5-0' Peek | Type: motorcycle, bike, night


text:
CloudShell Colony supports running application shell scripts and commands to be used in configuring, launching and checking the health status of your application. Reference to an application script should be added to your applications' YAML file under the Configuration section.
script: acme-dashboard-install.sh
command: >
dotnet /home/ubuntu/web/bin/Debug/netcoreapp2.0/publish/DSLibrary.dll
wait_for_ports: ALL
timeout: 180
You can reference three types of shell scripts that are executed in different stages of the application deployment and configuration process:
- initialization: This script's main function is to configure everything needed to run the application, including installing dependencies and downloading packages. For example, a typical initialization script might install a required software package and configure the database connection string. The initialization phase will not count towards the health check timeout.
- start: This is the actual command that will run the application. Colony will begin its health check process when this command runs. An example start script can be running the NginX process when starting a web server. You can either specify the command directly, as seen in the above example, or reference a script.
- healthcheck: CloudShell Colony already implements some basic checks which make sure that certain ports are ready. You can specify a specific port to check or just set the value as 'ALL', in which case all ports declared under 'connectivity' will be checked. The timeout property controls how much time (in seconds) Colony should wait for the health check to succeed.
- If you need more flexibility, you can add your own health check shell scripts. For example, the script below should return a message similar to "connected to: hostname". It will return "0" to signal successful deployment. Any other value would signal deployment failure.
script: demoapp-client-hc.sh
timeout: 1001
All script file references should be placed in your blueprint's repository, right next to the application's YAML file. For example:
As an example, let's review the WordPress application (Wordpress.yaml file) in CloudShell Colony's sample blueprint repository. The application uses a clean Ubuntu Linux image. Therefore, to install WordPress we need to run additional scripts after the instance is up. The scripts are included in the /wordpress folder, and we declare them in the wordpress.yaml file as follows:
script: wordpress.sh
script: wordpress-start.sh;
The wordpress.yaml file includes the following scripts:
- wordpress.sh: This is an initialization script, which takes the clean Ubuntu installation and installs everything needed to run WordPress. The script consists of the following steps:
- Update the Linux package manager.
- Install Apache web server.
- Install PHP and the required PHP modules in order to run WordPress.
- Download the latest version of Wordpress and install it.
- Configure the database access by modifying the wp-config.php files.
- wordpress-start.sh: This script runs only after the Initialization script completes. It usually starts or restarts an application process. In this example, this script restarts the Apache Web Server.
NOTE: CloudShell Colony does not expect the Start script to complete. It is expecting that the Start script might be the running application process.
Best Practices for Writing Application Scripts
To support you in creating reusable applications and to provide you with a self-service experience, CloudShell Colony includes some important features such as Local DNS service and user input parameters. To learn more about these features, see Working with Parameters and Best Practices for Writing Application Scripts.


text:
Selma, Alabama native, and Bengals NFL Defensive Player Michael Johnson returned this year with his 8th Annual Michael Johnson Youth Football and Cheer Camp!
Johnson introduced a Career Readiness Day for 8th Graders to kick-off the 2-day weekend presented by MDJ Enterprises to benefit the MJ93 Fund.
Mike continues to sow seeds into the youth with the gracious support of Go Build Alabama, Emergency Management Agency (EMA), Microsoft, Dallas County Extension Service, Selma Career Center, International Paper Company, Lockheed Martin, Hardees, ATCT (Air Traffic Control), Custom Home Design, Selma University, Diamond One Construction, Rehab Associates, Main Street Family Urgent Care, GEAR UP Alabama, Alagasco, Pioneer Electric Company and many others.
mjcamp-HD 720p from KINGSMEN MEDIA on Vimeo.
Thank you for having Kingsmen Media out for our 5th year at the camp! We really enjoyed it and you are a blessing to the the youth and the Selma Community!
Check out out some photos from the event!!!!


text:
A high quality food processor is the one appliance no kitchen should be without. Able to perform a variety of tasks, the Cuisinart Elite 12 cup food processor is a food preparation work horse. From chopping vegetables to pureeing soups, this food processor is a solid, well built choice that has garnered positive reviews from many who have used it.
This Cuisinart 12 cup food processor has many attributes that make it attractive to the home cook. First of all, this food processor is incredibly powerful. There are varying speeds available, maxing out at 1000 watts of power. It comes with 3 blades and 2 discs to handle any job in the kitchen with ease. The small blade is ideal for chopping and mixing. The large blade is also geared for chopping and mixing, just in larger quantities or for larger sized ingredients. The dough blade is a pastry chef or bread baker's best friend. The adjustable slicing disc has 6 variations to accommodate slices of different thicknesses. The reversible shredding disc produces fine or medium sized shreds; whichever size your recipe calls for.
Cuisinart has put a great deal of thought into the person that will be using their appliance. To ensure the user's safety, the discs have specific finger holes for handling and the blades have plastic areas that make them safe to handle when washing by hand or changing the blades or discs. There is cord storage that enables the cord to be wrapped around the machine and secured. This food processor comes with a 10 year warranty on the motor.
Click to View Pricing, Availability, and Reviews
All of the food preparation pieces on the Cuisinart FP-12 are safe to go in the dishwasher. Give them a good rinse first and they will come out sparkling after a cleaning cycle. Perhaps the greatest "pro" of all is the fact that this food processor comes with both small and large working bowls. At 4 cups and 12 cups, you can decide which to use to maximize you food preparation and minimize dishes to be washed. They also have marks for measuring and spouts.Both the work bowls are BPA free. This is especially important to families who are trying to reduce their exposure to BPA. The bowls are a polycarbonate material and safe for all who use them. This Cuisinart is very user friendly and even very novice cooks will feel comfortable using the bowls, discs and blades and easy to use touch pad. The Cuisinart FP-12 is able to turn nuts into nut butter and puree root vegetables with ease. The power of this food processor provides you with greater variety and opportunities for creating in the kitchen.
The gasket piece of this food processor can become caked with food quite quickly. If it's left to sit and dry out, it is extremely hard to clean. Whenever I use my machine, I make a point to always thoroughly rinse all the pieces out right away. I usually rinse it, then put it right into the dishwasher. I have washed it by hand if my dishwasher was full, but it's much easier to let the dishwasher do the work. Measuring in at 10.75″ X 11.25″ X 16.00″, this Cuisinart is a large appliance. It is not easy to tuck away, and since it is heavy, it is easier to leave it out on the counter.
Click to Get A Discount On The Cuisinart FP-12 Elite
The Cuisinart Elite food processor is a well built, high-quality machine that will last for many years and save a great deal of time in kitchen food preparation. It is a wise investment for families of all sizes, as it is the ideal appliance to prepare a snack for one or dinner for a crowd. I have complete confidence in recommending this food processor as I am a big fan of this model and know many others who are as well.


text:
A high quality, easy to use mountable well monitoring device.
The Well Watch 1100 is a simple to use self-contained semi-permanent acoustic ranging instrument designed specifically to find the distance through a pipe or bore hole to an obstruction which could be the surface of water in the hole or the dry bottom.
The product consists of a control unit and a probe. The control unit contains the driver electronics, processor, display, and keypad. Internal non-volatile memory is included to record system settings, calibration data, and log up to 14,976 data points. A real-time clock/calendar is also included to time stamp the recorded log data. The RS232 port can be set to output data to a remote device or used as a bidirectional communications interface to a computer for remote programming or data download. A power jack allows the unit to be run from an optional AC adapter or battery pack.
The probe contains a speaker, a microphone and temperature sensor in the probe tip. The probe is designed to easily attach to a standard well cap vent opening while also allowing the display unit to be operated in a convenient location up to 6 feet away.
The Well Watch transmits an acoustic pulse into the pipe, then measures the time to the returned echo. The distance is calculated as the product of the sound speed and the time. Since the sound speed has a large temperature dependence, a temperature sensor is included in the probe to adjust for variations.


text: Zac works closely with boards and management teams to deliver improved governance structure and set strategic objectives. Zac has previously worked with professional chartered accounting practices, as CFO of retail and rental companies and more recently as CEO in a Brisbane-based rental company. Zac specialises in providing advice to medium to large enterprises encompassing board structures, skills and assessments, CEO assessments, operational and strategic matters, and the identification of key business drivers and establishment of effective internal control systems to drive ongoing improvements.


text:
This article will be permanently flagged as inappropriate and made unaccessible to everyone.
Are you certain this article is inappropriate?
Excessive Violence
Sexual Content
Political / Social
Email Address:
Article Id:
Reproduction Date:
A cytotoxic T cell (also known as TC, Cytotoxic T Lymphocyte, CTL, T-Killer cell, cytolytic T cell, CD8+ T-cells or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected (particularly with viruses), or cells that are damaged in other ways.
Most cytotoxic T cells express T-cell receptors (TCRs) that can recognize a specific antigen. An antigen is a molecule capable of stimulating an immune response, and is often produced by cancer cells or viruses. Antigens inside a cell are bound to class I MHC molecules, and brought to the surface of the cell by the class I MHC molecule, where they can be recognized by the T cell. If the TCR is specific for that antigen, it binds to the complex of the class I MHC molecule and the antigen and the T cell destroys the cell.
In order for the TCR to bind to the class I MHC molecule, the former must be accompanied by a glycoprotein called CD8, which binds to the constant portion of the class I MHC molecule. Therefore, these T cells are called CD8+ T cells.
The affinity between CD8 and the MHC molecule keeps the TC cell and the target cell bound closely together during antigen-specific activation. CD8+ T cells are recognized as TC cells once they become activated and are generally classified as having a pre-defined cytotoxic role within the immune system. However, CD8+ T cells also have the ability to make some cytokines.
The immune system must recognize millions of potential antigens. There are fewer than 30,000 genes in the human body, so it's impossible to have one gene for every antigen. Instead, the DNA in millions of white blood cells in the bone marrow is shuffled to create cells with unique receptors, each of which can bind to a different antigen. Some receptors bind to tissues in the human body itself, so to prevent the body from attacking itself, those self-reactive white blood cells are destroyed during further development in the thymus.
TCRs have two parts, usually an alpha and a beta chain. (Some TCRs have a gamma and a delta chain.) Hematopoietic stem cells in the bone marrow migrate into the thymus, where they undergo VDJ recombination of their beta-chain TCR DNA to form a developmental form of the TCR protein, known as pre-TCR. If that rearrangement is successful, the cells then rearrange their alpha-chain TCR DNA to create a functional alpha-beta TCR complex. This highly-variable genetic rearrangement product in the TCR genes helps create millions of different T cells with different TCRs, helping the body's immune system respond to virtually any protein of an invader. The vast majority of T cells express alpha-beta TCRs (αβ T cells), but some T cells in epithelial tissues (like the gut) express gamma-delta TCRs (γδ T cells), which recognize non-protein antigens.
T cells with functionally stable TCRs express both the CD4 and CD8 co-receptors and are therefore termed "double-positive" (DP) T cells (CD4+CD8+). The double-positive T cells are exposed to a wide variety of self-antigens in the thymus and undergo two selection criteria:
Only those T cells that bind to the MHC-self-antigen complexes weakly are positively selected. Those cells that survive positive and negative selection differentiate into single-positive T cells (either CD4+ or CD8+), depending on whether their TCR recognizes an MHC class I-presented antigen (CD8) or an MHC class II-presented antigen (CD4). It is the CD8+ T-cells that will mature and go on to become cytotoxic T cells following their activation with a class I-restricted antigen.
With an exception of some cell types, such as non-nucleated cells (including erythrocytes), Class I MHC is expressed by all host cells. When these cells are infected with a virus (or another intracellular pathogen), the cells degrade foreign proteins via antigen processing. These result in peptide fragments, some of which are presented by MHC Class I to the T cell antigen receptor (TCR) on CD8+ T cells.
The activation of cytotoxic T cells is dependent on several simultaneous interactions between molecules expressed on the surface of the T cell and molecules on the surface of the antigen-presenting cell (APC). For instance, consider the two signal model for TC cell activation.
While in most cases activation is dependent on TCR recognition of antigen, alternative pathways for activation have been described. For example, cytotoxic T cells have been shown to become activated when targeted by other CD8 T cells leading to tolerization of the latter.[1]
Once activated, the TC cell undergoes clonal expansion with the help of the cytokine Interleukin-2 (IL-2), which is a growth and differentiation factor for T cells. This increases the number of cells specific for the target antigen that can then travel throughout the body in search of antigen-positive somatic cells.
When exposed to infected/dysfunctional somatic cells, TC cells release the cytotoxins perforin, granzymes, and granulysin. Through the action of perforin, granzymes enter the cytoplasm of the target cell and their serine protease function triggers the caspase cascade, which is a series of cysteine proteases that eventually lead to apoptosis (programmed cell death).
A second way to induce apoptosis is via cell-surface interactions between the TC and the infected cell. When a TC is activated it starts to express the surface protein FAS ligand (FasL)(Apo1L)(CD95L), which can bind to Fas (Apo1)(CD95) molecules expressed on the target cell. However, this Fas-Fas ligand interaction is thought to be more important to the disposal of unwanted T lymphocytes during their development or to the lytic activity of certain TH cells than it is to the cytolytic activity of TC effector cells. Engagement of Fas with FasL allows for recruitment of the death-induced signaling complex (DISC). The Fas-associated death domain (FADD) translocates with the DISC, allowing recruitment of procaspases 8 and 10. These caspases then activate the effector caspases 3, 6, and 7, leading to cleavage of death substrates such as lamin A, lamin B1, lamin B2, PARP (poly ADP ribose polymerase), and DNAPK (DNA-activated protein kinase). The final result is apoptosis of the cell that expressed Fas.
During hepatitis B virus (HBV) infection cytotoxic T cells play an important pathogenetic role. They contribute to nearly all of the liver injury associated with HBV infection and, by killing infected cells and by producing antiviral cytokines capable of purging HBV from viable hepatocytes, cytotoxic T cells also eliminate the virus.[2] Recently platelets have been shown to facilitate the accumulation of virus-specific cytotoxic T cells into the infected liver.[3] Recently, cytotoxic T cells have been implicated in the progression of arthritis: depletion of knee joint cartilage macromolecules such as glycosaminoglycans by cytotoxic T cells and macrophages has been observed in a rat model of the disease.[4]
Template:Immune system


text:
In January, mobile game developer Gree's free-to-play iOS and Android title Modern War introduced "live events" in which players join forces in real-time bids to take over the virtual world (which looks suspiciously like our world). The company has released an infographic showcasing the impacts of live events on the trigger-happy massively multiplayer online role-playing game.
The less-than-surprising part is that this addition has increased logins and player participation. Slightly less predictable, however, is that more people fought over Ireland than over any other country. But I guess that makes sense; whoever holds Fake Ireland controls the largest supply of virtual zinc in Digital Europe.
Click on the graphic for a larger version.
You can't solo security COVID-19 game security report: Learn the latest attack trends in gaming. Access here


text:
Mature IT workers back in vogue
- 17 December, 2007 11:26
For years they were shunned for being too old and uncool, but as the skills squeeze tightens, mature age IT workers are coming back in favour for companies seeking to fill voids in the workforce.
Relying on Gen Y workers to stay in jobs is forcing many employers to revert to the tried and tested, says Simon Lynch, national director of IT for recruitment firm Michael Page.
"In the past we would have had clients whose preference was to take the young up-and-comer," says Lynch.
"Now we are seeing the preference is more so to take a mature age worker. I shouldn't say that is all business, but we are starting to see a bit more flexibility there," he said.
"Businesses are starting to recognize now that with Gen Y, for a lot of these guys it is about them and not necessarily the company, and therefore they are not getting a lot of longevity out of the younger people.
Lynch said mature workers, mainly those above 50, can offer companies a wealth of experience and more importantly, loyalty.
"These guys are very employable and therefore companies who are willing to be flexible and look at that type of person are guaranteed to get that person until they retire."
On the whole, Lynch said a majority of his clients' demands are for staff with project management and business analysis skills. "From an IT perspective there are a lot of projects that go on so there is a constant demand for these skills."


text:
We often tend to think of fat as the big taboo when it comes to nutrition. The fact is however that, although we need to be weary of certain kinds, fats are essential building blocks for healthy brains. This can be seen in the fact that almost two thirds of the weight of the human brain is made up out of fat! The two main functions that fats perform in the brain are: Our falsifying beliefs about fats keep us ignorant. We presume that fats are not fit for nutrition but the reality is different. No doubt some fats are not good for nutrition but not all are bad. We must know about good categories of fats which keep our brains healthy by developing blocks in them. Almost two thirds weight of human brains is due to fats. Two major roles which fats play in brain are as follows: Whenever we talk of nutrition, we keep fats aside due to false presumptions. But the reality is totally different. Some specific fats are mandatory for a balanced and healthy brain. Certain categories of fats keep our brains balanced by building blocks in them. The findings are before us that fats make approximately two thirds of our brain's weight. Let's know two major roles which fats play for the effective functioning of our brains:
•Membrane formation: Systematic protection of human brain is done through the double layered membrane made up of fatty acids which surrounds neurons to protect it from external wastes. Membranes are pivotal in keeping the brain function effectively. They keep vigil of entry of micronutrients, glucose and oxygen in it which proves best for it. • Protection: Made up of 30% protein and 70% fat, the protective sheath named Myelin covers up neurons.
Lots of efforts are required to keep brain healthy. We knew from the above mentioned guidelines that healthy brain needs different types of fatty acids. Our bodies produce some of them but we can gain much from diets. Fatty acids derived from diets are known 'Essential Fatty Acids'. Some important fatty acids are mentioned below:• Alpha-linolenic Acid (ALA): Major components of 'Omega 3 Fatty Acids' are procured from ALA which can be have by eating various kinds of fish, nuts, seeds and vegetables. • Linolenic Acid (LA): 'Omega 6 Fatty Acids' have their important components in LA. Taking sunflower, corn and sesame oils are effective in getting them.
Two highly effective fatty acids Docosahegagonic Acid (DHA) and Arachidonic Acid (AA) respectively are prepared through regular intake of ALA and LA. It is done to keep the brain function systematically. As above mentioned acids are more complex than ALA and LA, they are crucial for the brain to perform complex roles. Its most important role is formation of membrane. Although our bodies produce DHA but it can also be directly gained from various diets. We must remain careful in it and shouldn't forget to use possible means to procure them as lack of this effective acid might bring untoward circumstances. Balanced diet is necessary for this as it acts like a supplement of DHA.
The importance of DHA to proper brain function, and therefore also to the management of ADD-ADHD, can hardly be overstated. Studies have shown that a lack of DHA can be linked to:
• Depression
• Parkinson's and Alzheimer's Diseases
• Cognitive Decline
• Hyperactivity Crucial role played by DHA for systematic functioning of brain and its effective role in managing ADD-ADHD cannot be ruled out. As per the research findings lack of DHA may lead to:
• Depression
• Parkinson's and Alzheimer's Diseases
• Cognitive Decline
• Hyperactivity We cannot rule out excellent contribution of DHA in helping our brains function effectively. It is pivotal in the management of ADD-ADHD too. The research finding describes that lack of DHA results into:
• Depression
• Parkinson's and Alzheimer's Diseases
• Cognitive Decline
• Hyperactivity
Why the above mentioned guidelines have negative results in our societies? An important reason of it is that our modern diets weaken fat values as they are hardly balanced. Hydrogenation process starts developing when natural fats are heated at extreme temperature. Resultantly the structure of fat molecules start altering badly and no naturalness remains in them. When such 'trans-fatty acids' developed in such manner enter into the nerve cells they don't accommodate them as per their actual requirement due to forced deformation and not being developed like DHA. Its bitter effect is realized in the brain cells which become rigid due to trans-fatty acids. Ultimately they do miscommunication which lead to severe bad impact between particular neurons. The output of such diets turns worst as their extreme trans-fatty acidic elements enforce the brain to perform badly.
The implication of all of the above is that your fat intake should be geared towards increasing the availability of 'good' fatty acids (Omega 3, Omega 6 and 'pure' DHA) and the avoidance of trans-fatty acids as far as possible. The maintenance of Health levels of body fat is also very important. Some 'fat management' strategies include the following:
• Avoid Hydrogenated Fats: The most common impetus for the creation of trans-fatty acids is the hydrogenation that occurs when oils or fat is heated at extreme temperatures. Do your best therefore to avoid deep fried foods as well as oils and margarines created or 'enhanced' through hydrogenation.
• Make the 'Omegas' an essential part of your diet: The 'essential fatty acids' (ALA and LA) can be made a regular part of your diet through regularly eating foods that are good sources of them.
Examples include cold water fish (salmon, trout, mackerel and sardines) in the case of Omega 3 and primrose, borage as well as eggs and diary in the case of Omega 6.
• Supplement where necessary: It may be necessary to take a regular supplement containing ALA, LA or even 'pure' DHA if you are not getting sufficient quantities from your diet.
• Manage body fat levels: The brain is full of blood vessels supplying it with energy and keeping it cool. Excessive amounts of body fat will lead to these vessels, and therefore the brain, functioning well below par. Make sure therefore that you manage the fat in your diet and that you reduce body fat even further through regular exercise.
Scholars and researchers agree to the fact that there is a strong link between lack of DHA and ADD-ADHD. It is at this perspective that fats should be dealt with. It doesn't make any sense you keep ignoring fats. Appropriate management of it by selecting diets which bust ADD-ADHD would be prudent.


text:
You can try a demo of Blades of Excalibur, an action fighting game from Kabam, without even leaving the YouTube video window. How cool is that?
Blades of Excalibur, an English localization of China's most popular game of 2013, will be available next month. The demo is a fairly simple hack-n-slash with roughly the sophistication of a Super Nintendo-era side-scroller. The interesting part is that it's hosted entirely within YouTube.
It's a small first step, but what if more complex games could be embedded into preview videos just like this? If, while watching a trailer or bit of gameplay for an upcoming game, the video paused and let you take over the controls for a bit. Sure, it might not be a full representation of the final game, but such a feature could give gamers a hands-on taste of how a game feels and plays when they least expect it.
If a cloud-based game streaming service like OnLive or Gaikai were integrated within YouTube, it could conceivably play higher-end console games via streaming. The site already hosts more than a billion unique viewers each month, so it would seem a natural extension of the idea.
But to me, that isn't even the most interesting possibility. I would argue that the average gamer has an inherent knowledge and understanding of most games that would come from a big budget publisher. Specific details aside, most first-person shooters play about the same. But what about indie games, where unique and innovative gameplay methods are common?
Oftentimes, some creative gameplay mechanic is a game's biggest draw, but also the hardest thing to demonstrate in a video. Take Jonathan Blow's acclaimed puzzle game Braid: A video can show that the flow of time can be controlled, but the actual implications of how that mechanic can be used are difficult to understand without using it yourself.
At the same time, most indies come with minuscule system requirements, as compared to triple-A blockbusters. In that case, maybe rendering a streaming gameplay demo natively in a browser in the middle of a YouTube video might not be difficult at all.


text:
Plus TV Africa, a 24-Hour news channel, will now broadcast across all of Africa via StarTimes platform. According to StarTimes, the performance of the channel is superior since its launch and upgrade where it is expected to reach over 30 African countries.
StarTimes Nigeria – CEO, David Zhang, "Plus TV Africa has done well during the pilot phase of the broadcast hence the upgrade to our dish platform. Right now, in all of Africa where we broadcast, Plus TV Africa can be enjoyed."
Also commenting, Managing Director/Editor-in-Chief at Plus TV Africa, Kayode Akintemi said: "The upgrade to broadcast Pan Africa is proof that the hard work the company has put into creating unique and engaging content for various category of audience has paid off."
Plus TV Africa is an Afropolitan 24 hour TV News Channel owned by General News & Entertainment Company (GNEC) Media Group. The station is set up to provide news content to cater to the African professional and the millennials who seek quality African news, stories and content.


text:
Is this YOU?
***Receive FREE, our UNSTOPPABLE RESULTS Training Blueprint E-book, to learn the REAL, PROVEN, KEY methods to achieve the BODY and FITNESS you want ***
Do you have regrets?
I certainly do, and they stick around with you for a life time, giving you that ultimate sense of failure
So I want to share with you the cure, based on a speech…
You may have seen this week me share the video of Apple founder Steve Jobs?
At the time of the speech, he announced how he had discovered he had pancreatic cancer…
And thankfully had overcome it
He said how he followed the mantra:
'Live everyday as if it was your last, and you'll almost certainly one day get it right'
With this approach, you don't regret, because YOU DO
Regret is the product of failing to act on doing something, which could have resulted in you achieving something remarkable…
Conquering a sporting challenge you had always yearned
Shedding the body fat that's been making you anxious for the last year
But its so easy not to do the training required (your tired, your stressed)
Not honestly adopt the nutrition required for change (you have no time, you drive too much)
And how often do you not act?
You might get close, but you fail to act and end up in the same place
(often using the age old excuses that we've all used above)
Its this lack of action which triggers the empty sense of regret further down the line
Take social media maniac Gary Vaynerchuk…
He always talks about how when he intentionally spent a lot of time around people in their 70's, the only thing they complained about was regret
Not taking a chance
Not relishing an opportunity
The sad irony with Steve Jobs is he wouldn't know a few years after that speech he would eventually succumb to illness and pass away, HOWEVER…
He lived, he took the opportunities, I guarantee he didn't regret and he achieved what he wanted
You can keep talking a good game…
You can keep making the same excuses you know deep down aren't genuine…
You can keep reading training and nutrition articles, even eye balling my e-mails each week…
But don't expect what you actually want (life impacting results in how your body looks, feels and performs)
Or, act, DO, in succeeding with your training goals, you'll end up with no regrets, and nothing but a bloody great sense of achievement
Speak shortly
Dave 'just saying it, as it truly is' Cripps
***Receive FREE, our UNSTOPPABLE RESULTS Training Blueprint E-book, to learn the REAL, PROVEN, KEY methods to achieve the BODY and FITNESS you want ***


text:
This item is temporarily out of stock. However, we can notify you as soon as this product becomes available.
Thank you
We have received your request and you will be notified as soon as this product becomes available.
In order to keep our prices as low as possible, all CreateForLess order subtotals must be at least $10. This helps us save on labor costs when packing your order so we can extend the savings to you!
Description: Eazy Peazy Zip It Monsters Treasure Keepers Pattern. What child won't love these whimsical keepers for their little treasures. Designs have 4 different monster faces, each with a zipper closure. Add a clasp for backpack or belt. Each made with two Bosal 8 inch circle Mug Rug forms, sold separately. Pattern includes full size template pieces. Finished size is approximately 8 inch.
1Orders placed must have a minimum subtotal of $10. More Info.
See more Eazy Peazy Patterns.
Review this product and Enter
to Win a $100 shopping spree!


text:
I read that the Klingon language enthusiasts' meeting in Germany this year has 25 confirmed attendees—more than the main meeting in the US this year, apparently!
Now I'm really sorry I won't be able to make it this year, either.
And calling it a qepHom (minor meeting) really is getting increasingly inaccurate.


text:
Regular Baptist Press
SCHAUMBURG, Ill.—The Regular Baptist Web Community will offer a free training webinar on Tuesday, Aug. 12, at 6:00 p.m. Central Time on "Reaching the 4–14 Window: Catch the #KidMin Vision."
Hosted by Alan Wilson, regional manager of Regular Baptist Press, this webinar will highlight ways to realize and capitalize on the opportunities to reach children ages 4–14. Children's ministry makes the most of a vital age window—whether it's a midweek program, Sunday School, or any kids' ministry opportunity. This webinar will encourage children's ministry workers to catch the vision and have a renewed excitement heading into their fall ministries.
To register, go to www.regularbaptistpress.org/resources/training/webinars and click the "Register now" button. The webinar is free.
About Regular Baptist Press
Regular Baptist Press offers a wide range of curriculum, VBS programs, Bible studies, books, and training seminars. RBP resources are Biblically sound, covering the entirety of Scripture, and are designed for spiritual growth.
Regular Baptist Press is the publishing ministry of the General Association of Regular Baptist Churches.


text:
Chances are the bustling beauty teams that style Claire Danes and Jessica Alba for regal red carpet events won't be showing up at my doorstep any time soon, because unlike the stars, we mere mortals must fend for ourselves when it comes to getting ready for parties and nights on the town (or nights on the couch with your cat, if you're also into that). 🙂
No problem. Getting glam doesn't have to involve a small army of beauty professionals (although, not gonna lie, if a pro prep team suddenly appeared — POOF! — I would NOT turn them away).
Recreating red carpet looks at home can be easy and fun, and with drugstore beauty products, it doesn't have to break the bank.
I recently gave two of my favorite red carpet looks a try from this year's Golden Globes — a look Claire Danes wore with smokey eyes and nude lips, and Jessica Alba's look with brown eyes and tangerine lips — both of which seemed simple and elegant, which I liked.
Gearing up for a big night? If you are, you can get red carpet ready like Claire and Jessica using makeup, hair, body and skincare products from COVERGIRL, Olay, Aussie and Secret.
Who says that going glam is reserved for the stars?
Inspired by: Claire Danes
Oh, Angela Chase. You've come so far since Jordan Catalano wrote that song
about you about his car…
I absolutely loved the wavy hair, smokey eyes and nude lips Claire recently wore. Hello, stunning!
1. Let the glamification begin: skin and hair
Start by prepping in the shower with a hydrating body wash like Olay Ultra Moisture Body Wash ($5.99), and washing and conditioning your hair with Aussie Aussome Volume Shampoo and Conditioner ($3.99 each).
Even if the paparazzi aren't currently stalking you, there's no reason to let 'em see you sweat, so swipe some Secret Clinical Strength Stress Response ($7.99) under those 'pits, girl!
Okay, time to tame the mane. Apply Aussie Aussome Volume Styling Mousse ($4.99) to wet hair for hold and volume, and either air or blow dry.
When your hair is dry, recreate Claire's waves by curling the ends with a large barrel curling iron. Then, mist your mane all over with Aussie You Can Shine Spray Gloss ($3) for red carpet shine.
2. Gotta prep
Ready to play with makeup? Me too, but let's get our skin ready first with face products from the Olay Professional Even Skin Tone Line, and disguise any uneven areas or imperfections by applying a liquid foundation like COVERGIRL Outlast 3-in-1 Foundation ($12.99).
If your skin tone's similar to Claire's, try the shade called Classic Ivory. I have a little — okay, a lot! — more of a tan, so something like Classic Tan works for me.
3. Sights set on smokey eyes
Now for my favorite part — the eyes!
Start by applying your favorite eye primer to your lids, curling your lashes and filling in your brows.
Next, for your smokey eyes, line both upper and lower water lines with COVERGIRL Perfect Point Plus Eyeliner in Black Onyx ($5).
With the same pencil, line your upper and lower lash lines; soften the lines by smudging the edges with a flat eye shadow brush.
Now, it's time to add the smoke!
Load your flat brush with a combination of black and blue shadows, like COVERGIRL Eye Enhancers 1-Kit Shadows in Shimmering Onyx and Sapphire Sparkle ($4.50 each). Combining the shades here adds depth to the smokey effect.
Pat the mix on your lids and barely into the creases. Then, using a domed blending brush, blend away any harsh edges.
To refine your smokey look even more, take your domed brush, and load it with your favorite blush. Something like COVERGIRL Instant Cheekbones Contouring Blush in Sophisticated Sable ($6) should work great for Claire's look.
Sweep your loaded domed brush into your creases and along your lower lash lines to soften the edges. This helps everything look a little more polished.
Finish up your eyes by applying a few coats of COVERGIRL Clump Crusher Mascara ($6.99).
4. Wrapping it up
From here on out, the rest is cake!
Sweep that same blush, Sophisticated Sable, on your cheeks, apply a nude lip color, like COVERGIRL Lip Perfection Jumbo Gloss Balm in Toffee Twist ($8.99) on your lips, and wrap up with a coat or two of COVERGIRL Outlast Nail Gloss in Forever Frosted ($5.99) on your nails.


text:
Job Description
An inspiring charity in Essex are looking for two passionate Fundraisers to join their team to produce revenue through management of a variety of activities to raise the profile of our clients cause, and in turn raise donations. The ideal candidates will have exceptional communicational skills and provide admirable customer support. You will have previous experience of providing fundraising services in a community/face to face supporter/legacy capacity.
Reporting to Community Partnerships Manager, as Fundraiser, you will be the key contact for supporters who are eager to raise funds for the charity and will be working effortlessly on the retention of existing supporters, as well as seeking out new fundraising opportunities.
Additional duties will include:
*Management of a portfolio of events and activities - from initial planning, to logistics, delivery and review;
*Recruiting volunteers and meeting with fundraisers and ensuring their experiences are personal and positive;
*Developing relationships with businesses within the local community who wish to contribute to fundraising efforts;
*Organisation of fundraising assistant to ensure they remain motivated and targets are met;
*Properly processing monies donated;
*General administration.
This is a fantastic opportunity to be part of a huge charity that makes a real difference. Due to the location of the office, this role is commutable from Romford, Chigwell, Brentwood, Dagenham and Basildon and most parts of Essex.
For registration purposes please could you let us know where you are currently based or which locations you are considering as well as your required salary and notice period. Please upload a Microsoft Word version of your CV where possible, excluding textboxes or images.
By applying to this position, you acknowledge and agree that your CV will be forwarded to the relevant employer as a matter of course, without further reference to you. The employer may then contact you in their sole discretion.
Any data we collect from you will be stored and processed in accordance with Brand Recruitment's Privacy Policy.
Search Brand Recruitment on Facebook, Twitter and LinkedIn to hear about all of our latest jobs.
Brand Recruitment offers the services of an employment agency for permanent work. Visit Brand Recruitment online http://www.brandrecruitment.co.uk/ to apply for other key marketing jobs in the Central and Eastern Region. If you have not heard back from us within seven days, please assume that your application has not been successful.


text:
Reversible Sherpa Hoodie
$89.00 $199.00
Item added to bagClose
Qty: 0
Bag subtotal
on orders over $120.00
Reversible Sherpa Hoodie
$89.00 $199.00
Size Chart
Product Details
SOFT & WARM: Our fuzzy fleece hoodie is made to provide you with a stylish way to stay comfortable and protect yourself from the cold while standing out and looking good. With elastic sleeve cuffs and bottom hem, it locks the warmth inside so you can enjoy all your favorite winter activities
- REVERSIBLE DESIGN: Why settle for a single design when you can choose our reversible Sherpa hooded sweater! Our Sherpa fleece hoodie is designed to be wearable on both sides giving you the freedom to mix and match it with the rest of your outfit to get the look you want while staying comfy
- STAY COMFY & COZY: Our Sherpa sweater is made using soft polyester Sherpa fleece that's thick, light and warm while providing a snug fit so you can stay comfortable whether lounging at home or on the go. It's easy to wash and goes seamlessly with any look making it the ideal choice for daily use
- FOR EVERY OCCASION: This soft and cozy fuzzy fleece hoodie is the perfect choice for all your indoor and outdoor activities. Whether you're hanging out with friends, going to a party or simply walking around town, you can count on this winter outwear sweater to make you look good while keeping you warm and comfortable
- A GIFT WORTH GIVING: If you're looking for the perfect winter gift for family or friends then you've found it. Our Sherpa fleece hoodie makes the perfect gift for almost any occasion including Birthdays, Anniversaries, New Year's, Valentine's Day, Christmas, and more
We designed this double sided pullover hoodie for men and women that want to stay warm and feel comfortable without sacrificing their looks. Each of our hooded sweaters for women winter are made using only thick and soft Sherpa fleece which coupled with the elastic sleeve cuffs and bottom hem locks in your body's warmth while preventing the cold air from getting in to keep you warm and comfortable around the clock.
You can effortlessly pair it up with your favorite pair of jeans or mix and match it with the rest of your wardrobe to get the look you want to stand out and look good without sacrificing warmth or comfort. Thanks to the reversible design you can wear it on either side which means you can choose from two colors depending on the rest of your outfit to add more versatility to your wardrobe.
Besides being the perfect addition to your wardrobe, our reversible Sherpa fleece hoodie also makes a thoughtful and practical winter gift for both friends on family on any occasion or event including Christmas, New Year's, Birthdays, Anniversaries or any other occasion you have in mind. Stay warm and comfortable in the cold winter while looking good with USA Palm reversible Sherpa hoodie jacket.


text:
Kodak has just launched a Mobile Service Postcard Application where users can send their photos taken with the cameraphone and make them into postcards which then can be sent to any address in the US.
Postcards can be sent on the Verizon Wireless network using the Motorola V710, V260, V265, V276; Kyocera KX2; and the Audiovox CDM-8940.
Via: WirelessWeek


text:
Hydrotech Solutions provides innovative water management technologies and services that improve water quality while conserving its use.
Our solutions reduce operating costs of water, energy and chemistry, which is validated with automated data collection. Property portfolios are analyzed to optimize water, energy and maintenance schedules.
Efficient Water Use
Our water technologies deliver cost reductions that improve sustainable practices for the long term; reducing energy and chemical use, saving water, while continuously capturing data for secure cloud-based analytics.
IoT Sensors & Analysis
We collect and analyze operating data to validate improved water and energy efficiencies. We provide secure online operating data to our clients for larger scale analytics using our tools or their Building management systems.


text:
Make better use of our best teachers
by Peter Goss
Published in The Sydney Morning Herald, Sunday 31 March
Dear NSW Education Minister Sarah Mitchell,
Congratulations on the government's re-election. Among your many tasks over the next four years, may I suggest the most important is to create dedicated roles for expert teachers, starting with the next enterprise bargaining agreement with the NSW Teachers' Federation.
These expert teacher roles would make all teachers more effective, lifting student results for generations to come.
Long-term reform takes political courage. The new roles won't immediately help with your
day-to-day job of overseeing 3000 schools and planning for 170 school building projects. But they are essential to achieving the long-term goal of turning pockets of excellence into a system of excellence.
You have one big political advantage: Labor's education spokesman, Jihad Dib, agrees with you on the broad strategic directions of school education, even if his specific priorities differ. This gives NSW a level of stability within which to test and implement big ideas.
And implementation is key. Neither top-down policy nor bottom-up experimentation will deliver the system-wide changes that are needed. Investing in expertise offers a different path. Teachers like learning from other teachers, and it's vital they learn from experts so that their practices are based on evidence about what works best in the classroom.
Expert teachers know the common misunderstandings that students face in each discipline, and how to overcome them. They know the best ways to move students from basic skills such as memorisation to higher-order skills such as critical thinking. They understand the evidence base, and how to apply it in practice.
But we rarely give expert teachers the task of helping other teachers improve: the school workforce has a very flat structure.
You're already on to this challenge. About 100 NSW classroom teachers now get paid more as "Highly Accomplished" or "Lead" Teachers (HALTs). This is a fantastic start, but NSW needs 50 times as many.
And it is not enough to certify an expert teacher as a HALT, if their day job stays the same. For expert teachers to have maximum impact, their role needs to be strategically designed – and backed by the school principal.
Grattan Institute's 2016 report Circuit Breaker argued for new "expert" and "master" teacher roles within and across schools. A mid-sized primary school might have two or three expert teachers.
Secondary schools would have more. Their day job would be to coach their colleagues and give personalised feedback, focused on a specific subject such as maths, science or English.
Master teachers would work across clusters of schools, setting high standards for pedagogical practice and building the next generation of expert teachers.
Current NSW workplace agreements lack these roles. Programs that employ instructional leaders – such as Early Action for Success – rely on workarounds to offer the right pay and conditions. And programs chop and change with the political winds.
Some high-performing education systems have learnt these lessons. Singapore and Shanghai, in particular, have Master Teacher and Expert Teacher career pathways along similar lines to our proposal.
NSW can't just import a model from overseas. It should create its own, starting with the once-every-four-years enterprise bargaining process scheduled for later this year. The pitch to the union is higher pay for the expert teachers, and higher status for the whole profession.
Accept the challenge, minister. Make dedicated roles for expert teachers part of your legacy.


text:
Everyone knows the fairy tale Aladdin, the much loved story about a poor boy who overcomes all and wins the heart of a princess. But do you know the pantomime version?
Aladdin is an impoverished young lad in a Chinese town. He is recruited by the magician Abanazar, who passes himself off as the brother of Aladdin's late father, convincing Aladdin and his mother, Widow Twankey, of his goodwill by apparently making arrangements to set the lad up as a wealthy merchant. Abanazar's real motive is to persuade Aladdin to retrieve a wonderful oil lamp from a magic cave. After Abanazar attempts to double-cross him, Aladdin finds himself trapped in the cave. Fortunately, Aladdin retains a magic ring lent to him by Abanazar. When he rubs the ring, a "genie" appears, who takes him home to his mother. Aladdin is still carrying the lamp and when his mother tries to clean it, a second more powerful genie appears who is bound to do the bidding of the person holding the lamp. With the aid of the genie of the lamp, Aladdin becomes rich and powerful and marries Princess Yueliang, the daughter of the Dragon Empress of China. The genie builds Aladdin a wonderful palace – far more magnificent than that of the Empress herself.
Abanazar returns and is able to get his hands on the lamp by tricking Aladdin's wife, who is unaware of the lamp's importance, by offering to exchange "new lamps for old". He orders the genie of the lamp to take the palace to his home in Egypt. Fortunately, Aladdin retains the magic ring and is able to summon the lesser genie. Although the genie of the ring cannot directly undo any of the magic of the genie of the lamp, she is able to transport Aladdin to Egypt and help him recover his wife and the lamp and defeat Abanazar.
With references to everything from Starbucks and easyJet to the Danish royal family, musical numbers and fabulous costumes, there was something for both children and adults that holiday season. We booed the villains, cheered the hero and heroine, sang along to the tunes and thrilled to the fabulous dance routines.
Krudttønden, Serridslevvej 2, 2100 Kbh. Ø (www.krudttonden.dk)
Pantomime Exhibition
Saturday 12th January 2013
Øbro Jagtvej Bibliotek 10 o'clock and at Østerbro Bibliotek 11.30
Guest appearances by the cow from the Cinderella pantomime and the "Dame" (Widow Twankey) from Aladdin, played by Iven Gilmore and Aladdin himself, played by Sébastien Bagot.


text:
it's been three weeks. Three long weeks considering how difficult and painful it has been not having you in this world. But time has also passed so fast considering it's already been three weeks since you were freed from this world.
I fear losing memories of you, E. yesterday for the first time I heard of your death, I wasn't experiencing constant heart break. By losing sadness that drowns me, am I losing you even more? I want to hold on to you, remember you in sadness and in joy, in pain and your unmatchable energy and enthusiasm for life.
you know, you brought the best in people because you believed in them; you believed that they could be good. with kids you could show them unconditional love. and yet it was unconditional love that felt to you to be out of reach for you to receive. only God could hold you in unconditional love that does not disappoint.
in someways we have all failed you, failed to see your internal turmoil, your vulnerability and your fragility. but a breathe of lovely beauty you were, not so much the resilient sturdy self you wanted to project.
E, you are safe now. the world cannot touch you where you are now. the love of your life, God, stands by you forever and an eternity, never letting you down or leaving you to be alone.


text:
Comparison of Two Triple Regimens for Treatment and Retreatment of Chronic Hepatitis C Infection
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01771653
Recruitment Status : Completed
First Posted : January 18, 2013
Last Update Posted : January 18, 2016
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Hepatitis C Infection
|Study Type :
|Actual Enrollment :
|37 participants
|Observational Model:
|Time Perspective:
|Official Title:
|Comparison of Two Triple Regimens for Treatment and Retreatment of Chronic Hepatitis C Infection
|Study Start Date :
|September 2011
|Actual Primary Completion Date :
|July 2015
|Actual Study Completion Date :
|July 2015
Previously treated
Data from patients who were previously treated with Peg, interferon (IFN), alfa, and ribavirin
Previously untreated
Records of patients who have never received anti-HCV treatment.
- Virologic Response [ Time Frame: up to 96 weeks post treatment ]Sustained Virologic Response (SVR) rates will be compared between the two arms of treatment through measured HCV RNA levels after 24 weeks, 48 weeks and 96 weeks after completion of treatment.
- Adverse events [ Time Frame: 24, 48, and 96 weeks post treatment ]Comparison of rates and severity of adverse events between the two study arms
- Effect of baseline variables on treatment outcome [ Time Frame: 24, 48, and 96 weeks post treatment ]Analyze the effects of baseline variables on treatment outcome between the two groups- age, race, social economic status.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 64 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
|Sampling Method:
|Non-Probability Sample
Inclusion Criteria:
- Age - 18-64 years
- HCV genotype 1
- Liver biopsy within 5 years before enrollment
- Absolute neutrophil count of at least 1200 per cubic millimeter
- Platelet count of at least 90,000 per cubic millimeter
- Hemoglobin level of at least 12 g per deciliter
- Signed informed consent and Health Insurance Portability and Accountability Act (HIPAA) forms
Exclusion Criteria:
- HCV genotypes other than genotype 1
- Immunocompromised conditions including HIV, transplant or immunosuppressive drugs
- Decompensated liver disease or hepatocellular carcinoma
- Any other types of active cancer
- Active autoimmune disorders
- Major psychiatric disorders
- Active drug or alcohol use
- Pregnancy or lactation
- Patients with allergy to any of the drugs used in this study
- Drugs that may interact with boceprevir or telaprevir as listed in the package insert
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01771653
|United States, Illinois
|Southern Illinois University School of Medicine
|Springfield, Illinois, United States, 62701
|Principal Investigator:
|Janak Koirala, MD, MPH
|Southern Illinois University School of Medicine
|Responsible Party:
|Southern Illinois University
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|January 18, 2013 Key Record Dates
|Last Update Posted:
|January 18, 2016
|Last Verified:
|January 2016
Hepatitis C infection
Hepatitis C Virus
Communicable Diseases
Hepatitis A
Hepatitis C
Hepatitis C, Chronic
Liver Diseases
Digestive System Diseases
Hepatitis, Viral, Human
Virus Diseases
Enterovirus Infections
Picornaviridae Infections
RNA Virus Infections
Flaviviridae Infections
Hepatitis, Chronic


text:
RAWALPINDI Nov 28 (APP): Chief of Army Staff (COAS) General Raheel Sharif, on Monday said it was a matter of great pride for him to have commanded the most battle hardened Army in the world for three years.
Chairing the farewell Corps Commanders conference held here at the General Headquarters, the COAS appreciated the commanders for their cooperation during his tenure and said the successes achieved during his tenure would not have been possible without contribution by each one of them.
General Raheel congratulated General Qamar Javed Bajwa, Chief of Army Staff designate, for his elevation to the rank of General and appointment as COAS.
During the meeting, as reported by Inter Services Public Relations (ISPR), the corps commanders paid rich tributes to General Raheel Sharif for his leadership and professional acumen and lauded his services for the country.


text:
Okay, so I hadanother bad week
. That's what I get for trying to get a monkey's help. But I'm not giving up. I'm going to get to the .500 mark at some point this football season. I was 6-7 last week, and I'm 47-69 for the season.
1. The Texans are 3 point underdogs to the Raiders. That's it? Only three point underdogs. This is the Texans we're talking about. Sure, the Raiders aren't that great, but damn, this is the Texans. Schaub's not playing. Andre Johnson's not back yet. Ahman Green still has a bad knee. Gary Kubiak's still the coach. Take the Raiders.
2. The Eagles are favored by 3 points over the Cowboys. This makes about as much sense as the Raiders only being favored by three points. Sure, there's that Tony Romo/Britney thing. And that whole T.O. returning to Philly thing. But I don't care. Take the Cowboys.
3. The Falcons are favored by 3 points over the 49ers. Wow, how bad do you have to be to an underdog to the Falcons? Well, I don't think the Niners are THAT bad. Take the Niners.
4. The Bengals are favored by 1 point over the Bills. I think the Bengals are falling apart. I think the Bills are coming together. And Lee Evans is going to go nuts against this Bengal secondary. Take the Bills to win.
5. The Browns are favored by 1.5 point over the Seahawks. The Browns are the surprise team of the season so far. They've got a winning record and Brady Quinn hasn't even had the chance to play. Take the Browns.
6. The Lions are favored by 3 points over the Broncos. Mr. Jesus Freak Jon Kitna is in trouble over his Halloween costume in which he mocked a Lions coach who'd been arrested on a DUI last season and found driving naked. But I don't believe in the Broncos. I think God forgives Kitna. Take the Lions.
7. The Chiefs are favored by 2 points over the Packers. Brett Favre had one of those incredible games Monday. This means that he's due to have a bad one. And this game is in Kansas City, so the Chiefs have home field. I don't care. Take the Packers.
8. The Patriots are favored by 5 points over the Colts. Wow, you mean these two are playing this week? I didn't know that. The word on the street is that there are many in the NFL who are getting upset about the Patriots running up the score. And the Patriots remind me of that bully just waiting for some kid to fight back. The Colts are that kid. The Colts win this game, and Peyton Manning shows Tom Brady who the best QB in the NFL really is.
9. The Saints are favored by 3.5 points over the Jaguars. The Jags found a way to win the game last week. The Saints seem to be trying to save their season. I think the Saints win this game. Take the Saints.
10. The Chargers are favored by 7 points over the Vikings. The Vikings have Adrian Peterson, but don't know how to use them. They deserve to lose just for that. The Chargers seem to be overcoming the fact that Norv Turner's the coach. Take the Chargers.
We Believe Local Journalism is Critical to the Life of a City
Engaging with our readers is essential to the mission of the Houston Press. Make a financial contribution or sign up for a newsletter, and help us keep telling Houston's stories with no paywalls.
Support Our Journalism
11. The Bucs are favored by 3.5 points over the Cardinals. I'm just not sure about this game. I'm not sure about the Bucs, about Jeff Garcia. But the Cards just make no sense to me. This game is in Tampa, so take the Bucs.
12. The Titans are favored by 4 points over the Panthers. I think David Carr is playing this week, but I'm not sure if the Panthers are sure about this, yet. And Vince Young hasn't looked great. He looked awful the last time out. But the Titans find ways to win games. Take the Titans.
13. The Redskins are favored by 3.5 points over the Jets. The Redskins were embarrassed last week. The Jets have a new QB. And the Jets stink. Take the Redskins.
14. The Steelers are favored by 9 points over the Ravens. The Ravens are quick becoming the NFL version of the Nebraska Cornhuskers. And the Steelers just seem to do what it takes to win. Take the Steelers. -- John Royal


text:
One of the most interesting pictures I've stumbled upon. I don't know if this pic represents hope, but it surely does make me think a lot.
2 comments:
It represent that life is balance.. if you try to mess up with one, then everything will tumble down..ReplyDelete
Once you balance everything, then your foundation remains so strong that you can sit on the Golden chariot, enjoy the cool breeze near the sea shore..
Conclusion: as you rightly said..it puts you in the thinking mode..
WOW!!! Thanks for the explaination, I kept wondering what it meant.. Thanks! :)ReplyDelete
Subscribe to: Post Comments (Atom)


text:
As many saw last week I Tweeted about upgrading to WordPress 3.3 and I found out I had to upgrade to MySQL 5. The good news is I have been using MySQL5 with Drupal and a couple of other sites for a while. The upgrade process was seamless, I simply used the Export content and then import content feature from the WordPress Export/Import plugin.
After I installed everything I decided to change the look and feel and just use an out of the box theme, the Twenty Eleven theme. I then carefully went through all of my own photos from around the world and used them instead of the canned photos that came with the theme. In case you don't want to hit refresh of my home page a hundred times, here they are:


text:
Please use this identifier to cite or link to this item:
|Developmental Neurotoxicity Testing Using In vitro Approaches
|HOGBERG Helena
|University Press
|Publication Year:
|PhD Theses
|There is a main concern about children¿s health as the developing brain in foetuses and children is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that the adult brain is well protected against chemicals by the blood brain barrier (BBB) and children have increased absorption rates and diminished ability to detoxify many exogenous compounds, in comparison to that of adults. Moreover, the development of the central nervous system (CNS) is a very complex process involving several different important events, e.g. proliferation, migration and differentiation of cells. These events are occurring within a strictly controlled time frame and therefore create different windows of vulnerability. Furthermore, the brain is consisting of numerous of different cell types (neuronal, glial and endothelial cells) that have specific functions. The development of each cell type is at a special time window and is therefore susceptible to environmental disturbances at different time periods. Evidence indicates that exposure to industrial chemicals, pesticides or drugs, is contributing to the increasing incidence of neurodevelopment disorders. However, due to lack of studies only a few industrial chemicals have been identified as developmental neurotoxicants so far. The current developmental neurotoxicity (DNT) guidelines (OECD TG 426 and US EPA 712-C-98-239) are based entirely on in vivo studies that are both time consuming, complex, costly and not suitable for testing of a high number of chemicals. Applying alternative approaches such as in silico, in vitro and non-mammalian models as a part of an integrated test strategy, could speed up the process of DNT evaluation and finely reduce and refine animal usage. Both in vitro and non-mammalian test systems offer the possibility of providing an early screen for a large number of chemicals, and could be particularly useful in characterising the compoundinduced mechanism of toxicity of various developmental processes. This thesis has characterised two primary neuronal cultures (cerebellar granule cells (CGCs) and cortical neuronal cultures) and recognized them as relevant models for DNT testing as the key processes of brain development such cell proliferation, migration and neuronal/glial differentiation are present. Furthermore, two emerging technologies (gene expression and electrical activity) have been evaluated and were identified as promising tools for in vitro DNT assessment. In a combination with other assays they could be included into a DNT intelligent testing strategy to speed up the process of DNT evaluation mainly by initial prioritization of chemicals with DNT potential for further testing.
|JRC Directorate:
|Institute for Health and Consumer Protection Historical Collection
Files in This Item:
There are no files associated with this item.
Items in repository are protected by copyright, with all rights reserved, unless otherwise indicated.


text:
If you are a business or resident based in Worthing, we can help support you with your IT needs, on going support and maintenance. For all of us here at Woodstock IT, it's about the service – providing our customers with the best IT support possible and helping as many businesses as we can. It's why we offer help to those in Worthing as well as Horsham, Crawley and the many other areas we cover in Sussex.
Looking after your IT
With IT being such a vital factor, you need to have everything set up properly and a maintenance plan in place. That's where we come in. We help businesses run efficiently and productively by providing a range of IT support and computer repair services. Network set-ups from one machine through to a full network, online and offline back up solutions and even the supply of computers, servers and peripherals – you name it, we can do it.
We even offer a range of support contracts for businesses. Receive priority call outs, telephone support, discounted products and upgrades for total peace of mind.
A great review from one of our happy customers:
After arriving promptly and on-time. Woodstock listened to the issues we were having and advised on a solution in easy-to-understand language at a fixed cost. We felt extremely confident with Woodstock's attitude and IT knowledge, response to queries within 1 day following work completion and after sales support where teething troubles (due to previous IT provider' s incompetence') were experienced. We would definitely recommend this company following 7 other companies that have let us down, who are based in Sussex. – Customer based in Worthing, Sussex.
Business Support
We offer second to none business IT support, and pride ourselves on offering a stress-free approach and aim to minimise any potential downtime. We know how important computers and broadband are for a company so if you encounter any issues we will deal with them as quickly as possible to prevent further disruption.
Residential Support
We offer a fast and effective approach to residential IT fixes and improvements. Whether you're having an issue with your antivirus system, need help with your broadband speed, or even with video chatting relatives abroad. Our friendly, expert team are on hand and just a call away.


text:
In response to widespread user feedback, Halfpricesoft.com has updated its ezW2 payroll software to include an improved installation package, easier access to help features, and an ability to be installed on a wider variety of devices. The 2012 version of the tax software also lets users to add unlimited companies and recipients to their account and to print an unlimited number of W-2 and 1099 forms for a nominal fee. Previous version of the software can now print the Social Security Administration-approved laser substitute W-2 and W-3 forms on ordinary copy paper from a laser printer.
For forms other than 1099 MISC copy A and 1096, users may also print to plain paper. The new ezW2 also supports 2-red-form-per-sheet printing to help organizations cut the costs of purchasing the pre-printed forms.
"We intentionally engineered this W2 and 1099 form software for those end-users who are not professional accountants and payroll tax experts," said Dr. Ge, President and Founder of halfpricesoft.com, "You don't even need to have much knowledge of computers. We believe small business software should be simple – stupid simple – so that owners can focus their time and energy on running their businesses, not trying to figure out how to run payroll software."
The other main features offered in the new 2012 software edition include: the importation of employee and contractor data from .csv files, PDF support, and support for e-filing.


text:
Unigine is a multi-platform (Windows / Linux / Mac OS X / PlayStation 3 / Android / iOS) real-time 3D engine, which unleashes the ultimate power for creating interactive virtual worlds (both modern games and virtual reality systems).
No members were found matching the criteria specified. We suggest you try the member list with no filter applied, to browse all available. Join now to share your own content, we welcome creators and consumers alike and look forward to your comments.


text:
Up until a few years ago, I had never done the long-distance relationship thing before. Not really really.
My first real experience with a long-distance relationship was my current relationship: a beautiful love story that takes place between France and the United States. Though my partner and I are now at a point where we will be married and living in the same place together long-term, 3 years of traveling between two countries and sustaining a 4,000+ mile long distance relationship is no small feat!
So, speaking from personal experience, here are some things I've learned that make being in a long-distance relationship sustainable, and maybe even pleasurable:
1. Listen to your heart.
There will be many ups and downs. There will be the time when you're about to be apart after some time together, and the thought of being without your partner seems unthinkable.
There will be times when things roll along blissfully, where you're receiving all the good and none of the bad of a long-distance situation: you're both in your separate worlds and you have more time with friends, more time for personal projects, and you feel an underlying assurance that your partner is still there for you and that you get to connect with them over video chat or via message when you want to.
Then there will be the difficult times – the times when you don't feel as close to your partner, or maybe they say something weird at the end of a call and you're not sure how to feel until you speak with them again. Maybe they don't have time to call when they said they would, or maybe you forget exactly what your connection feels like in real life and begin wonder whether it's all worth it.
Finally, there will be the times when you reunite. When your body and spirit is a typhoon of excitement and jitters. That moment when you see them again after days or months (or more) apart, and you feel yourself fall head-over-heels in love more deeply than you ever thought possible as if it's the very first time you met.
The point is, no one can tell you the future of your relationship. It is up to you and your partner to write your love story. In my opinion, if your hearts is softly telling you, "it's worth it," then keep going. Let yourself believe. Which brings me to…
2. Develop the capacity to trust. And then do it.
I believe a great misconception about relationships in general is that trust comes from somewhere outside ourselves. It's true that by trusting, we make ourselves vulnerable to being hurt by someone who may not be trustworthy. And yet, we can't expect another person to come along and reassure us over and over (and over) again that we can trust them. It's ok to ask for reassurance sometimes, but the real engine for creating trust comes from within ourselves, especially if we have been hurt in the past.
When we learn, somewhere along the line, that it is not safe to trust, it's up to us to work with that part of ourselves that is afraid to trust again. If your partner has given you no reason not to trust them, and yet you still feel afraid all the time, it's time to imagine and develop a sense of trust within.
What does trust feel like inside your body? Can you imagine what it would feel like to trust your partner deeply? And can you have faith that you are creating the relationship of your dreams, and that if for some reason you were not with someone you should trust, that that relationship will naturally improve or dissolve as you learn to feel trust and self-love more and more deeply?
I promise that if you practice actively feeling trust in your body, your partner will notice, consciously or unconsciously, and do more things that keep that trust flowing smoothly. Try it and see.
The counterpoint to this practice is…
3. Figure out what you need. Ask for it. And then give it to yourself.
In my opinion, asking for what you need and giving what you need to yourself are two sides of the same coin, and it takes practice and experience to strike a fine balance between the two. Don't expect to get it right every time. If you play with these two ideas (the operative word being "play"), you will discover what works for you and your partner.
Need more connection time? Ask for it. Don't expect your partner to have already read your mind, and don't attack them for not having figured it out sooner.
Try saying something like, "I love when we talk and I feel so connected to you, I feel so happy. Can we do this more often?"
Notice how this request comes from a place of already feeling happy and fulfilled about something, not from a place of lack or complaining.
And the times when it's simply not possible for your partner to meet your needs, for whatever reason, try giving yourself the feelings you would feel if your partner was able to give to you in that moment. That may sound silly, but what it does is keep you in a positive state of mind and ready to connect when your partner is able to come back around and connect with you. You then have time to reflect on any requests you would like to make in the future. And they will be happy to see you happy!
4. Remove blame from the equation.
Really, does anyone like to feel blamed? Ok, so maybe your partner did something you didn't like. Or maybe they didn't do something they said they would do. Maybe whatever it was wasn't terribly important to them, but it was important to you.
Whatever feelings you have about the situation, they are valid. Learn to really honor your emotions and to really feel them inside yourself. Not to the extent that you traumatize yourself over and over again, but enough to be able to let them flow and eventually let them go.
At the same time, be willing to communicate what you are feeling without directly blaming your partner. Own your feelings, and then tell your partner what action on their part led to you feeling that way. Almost every time (with a healthy partner), the slight was unintentional and based on a difference in experience or perception.
Be willing to learn about your partner's shortcomings and accept them without blame, and your partner will be more willing to learn what makes you truly happy, and over time their actions will support and reflect this level of care and understanding more and more. And often times, your partner will begin to learn from your improved behavior. This is what I have found to be true in a healthy relationship.
5. Learn to be ok with sometimes not being ok.
Once in a while, things will just suck, for lack of a better term. Long-distance relationships can be hard. Especially when the relationship is new, there can be a steep learning-curve around what makes each of you tick, and it may not be obvious at every turn what's really going on in the relationship.
Learn to really hold yourself, both physically (i.e. wrapping arms around yourself or cuddling a pillow or stuffed animal) and emotionally (sending love in toward your own heart and being present with your emotions). During the moments when your partner is not there and you need love, becoming good at self-love is an invaluable skill. You can even imagine a being that is holding you tenderly, just to help you get the feelings of love inside of your body.
It's ok for self-love to feel hard at first. Self-love is a skill that gets better with practice. However, all of your relationships will benefit if you learn to relentlessly love yourself no matter how happy you already feel in your relationship.
6. Develop the capacity for commitment. And then do it.
All relationships thrive with some form of commitment, but a long-distance relationship tends to make the need for commitment more obvious. Just like trust, if you want commitment in a relationship, you must first learn what commitment feels like within your own body.
I personally struggled for years in relationships where I did not feel like I was getting the commitment I wanted from partners. During the process I noted that I didn't have any role-models in my life to show me what commitment looked like – true commitment between partners was essentially foreign to my nervous system.
At last, in my current relationship, it all began to click. I realized that if I truly wanted the kind of deep, lasting commitment I was seeking, it wasn't just up to my partner to "give" that to me. I needed to first learn how to feel commitment within myself. When I began to practice feeling the feelings of commitment internally, deeper and deeper commitment began showing up in my relationship.
So there you have it.
I hope some of these ideas prove useful on your adventures in long-distance relationship! These are just some ideas based on what I found to be true during my time in a long-distance relationship. Since every relationship is different, your mileage may vary.
Have you ever been in a long-distance relationship, or are you in one now? What have you found to be helpful in creating the relationship of your dreams when you're apart and when you're together? What is easy for you as a couple? With what do you struggle? What other topics would you like me to cover in this blog?
As always, I welcome your feedback, comments, and questions.
Your friend and ally in love,


text:
Snapchat Superstar Makes A Living From Snaps
Snapchat Success Story
Now, we have our first person who makes his entire living solely from Snapchat. I wish I could get away with that, unfortunately I think there'd be limited interest in getting sent a few pictures of my dog every day.
Shane McBride who goes by the Snapchat alias of Shonduras gained a huge following on the picture messaging app thanks to his funny snaps often accompanied with Snapchat art. He's also been tagged as quite the storyteller making good use of Snapchat's 'Story' feature. It's proven to be so popular that Shane actually makes a living from his snaps.
In a video revealing his tricks, Shane commented on how he enjoys Snapchat because it's not driven by followers, likes and discussions. He believes that most of social media discussion is driven by negativity and causes people to be unhappy. Whereas Snapchat just revolves around sending funny pictures to make people smile.
Take a look at the video here:
Shonduras' Snapchat skills really highlight how we can make a living out of just about anything nowadays.
He's not the only one taking to picture based social media to make a living.
There are two guys in New York who make all their money by uploading pictures of their meals to Instagram.
I remain a little perplexed as to how they manage to turn over a profit when they're eating out for every meal.
Though I can't deny that I'm so utterly jealous of what they do, I'm starving just reading up about them.
Either way, I think it's time to get some more snap chatting done.
I've got a salad for lunch. Anyone want a picture of it? ... Hello?
Tom has just graduated from University of East London in Creative and Professional Writing. He loves writing and he currently manages, edits and writes for this blog. His other loves include Arnold Schwarzenegger films and his dog. Follow him @TomAtSMF
Contact us on Twitter, on Facebook, or leave your comments below. To find out about social media training or management why not take a look at our website for more info http://socialmediacambridge.co.uk/.
Snapchat Superstar Makes A Living From Snaps Reviewed by Unknown on Friday, January 16, 2015 Rating:


text:
Realtree Girl G304
These sophisticated Realtree Girl G304 glasses with layers of color and camouflaged temples will show off your style and your love of the outdoors.
- Brand authenticity guaranteed
- Realtree Girl logo on temples
- Eyeglass case and cleaning cloth included
- Age Range: Adult
- Frame Type: Full Frame
- Frame Material: Plastic
- Frame Shape: Rectangle
- Frame Type: Progressive Eligible
- Brand: Realtree Girl
- Frame Weight: Light
- Frame Size: Medium
Frame Size
Have a Frame That Fits?
Frame measurements may have slight differences depending on the options selected above.