text:
- Watts TH. TNF/TNFR family members in costimulation of T cell responses. Ann Rev Immunol 2005, 23: 23-68.
- Snell LM, Lin GH, McPherson AJ, Moraes TJ, Watts TH. T-cell intrinsic effects of GITR and 4-1BB during viral infection and cancer immunotherapy. Immunological reviews 2011, 244(1): 197-217.
- Clouthier DL, Watts TH. TNFRs and Control of Chronic LCMV Infection: Implications for Therapy. Trends Immunol 2015, 36(11): 697-708.
- Chang Y-H, Wang K, K-L C, Clouthier DL, Tran AT, Torres Perez MS, . . . Watts TH. Dichotomous expression of TNF Superfamily Ligands on Antigen-Presenting Cells Controls Post-priming Anti-viral CD4+ T cell Immunity. Immunity 2017, 47: 943-958.
- Wang C, McPherson AJ, Jones RB, Kawamura KS, Lin GH, Lang PA, . . . Watts TH. Loss of the signaling adaptor TRAF1 causes CD8+ T cell dysregulation during human and murine chronic infection. The Journal of experimental medicine 2012, 209(1): 77-91.
- Clouthier DL, Zhou AC, Watts TH. Anti-GITR Agonist Therapy Intrinsically Enhances CD8 T Cell Responses to Chronic Lymphocytic Choriomeningitis Virus (LCMV), Thereby Circumventing LCMV-Induced Downregulation of Costimulatory GITR Ligand on APC. J Immunol 2014, 193(10): 5033-5043.
- Zhou AC, Wagar LE, Wortzman ME, Watts TH. Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung. Mucosal Immunol 2017, 10(5): 1294-1309.
- Wagar LE, Gentleman B, Pircher H, McElhaney JE, Watts TH. Influenza-specific T cells from older people are enriched in the late effector subset and their presence inversely correlates with vaccine response. PloS one 2011, 6(8): e23698.
- Wagar LE, Rosella L, Crowcroft N, Lowcock B, Drohomyrecky PC, Foisy J, . . . Watts TH. Humoral and cell-mediated immunity to pandemic H1N1 influenza in a Canadian cohort one year post-pandemic: implications for vaccination. PloS one 2011, 6(11): e28063.
- McPherson AJ, Snell LM, Mak TW, Watts TH. Opposing roles for TRAF1 in the alternative versus classical NF-kappaB pathway in T cells. The Journal of biological chemistry 2012, 287(27): 23010-23019.
- Abdul-Sater AA, Edilova MI, Clouthier DL, Mbanwi A, Kremmer E, Watts TH. The signaling adaptor TRAF1 negatively regulates Toll-like receptor signaling and this underlies its role in rheumatic disease. Nat Immunol 2017, 18(1): 26-35.
TNFR family members and TRAF proteins in viral infection, inflammation and cancer
Upon an infection, the innate and then the adaptive immune system are rapidly ramped up to control and then clear the infection. T cell activation requires the recognition of an antigen-MHC complex by the T cell receptor (signal 1) along with a costimulatory signal from CD28 (signal 2) and additional signals from cytokines (signal 3). When T cells are activated, they upregulate members of the tumor necrosis factor receptor (TNFR) superfamily. Our laboratory has had a long-standing interest in this family of receptors, which play important roles in controlling life and death in the immune system (1-3). An overriding question in our laboratory is why we need TNFR family members in addition to CD28 family molecules during viral infection. Our recent data, show that TNFR family members on T cells binding to TNF superfamily ligands on inflammatory monocyte-derived antigen presenting cells, provide a critical post-priming checkpoint (signal 4), to allow T cell accumulation during viral infection (4).
The persistent induction of stimulatory TNFR superfamily members on T cells during chronic infection raised the question of how the immune system avoids excessive TNFR family stimulation. Our laboratory has shown that TNFR family signaling is tightly controlled during chronic infection. In the case of the costimulatory TNFR family member 4-1BB, the pathway becomes desensitized during chronic viral infection, through loss of a key signaling adaptor TRAF1 (5). In contrast, within a few days of a chronic viral infection, the TNF family ligand GITRL is downregulated below baseline (4, 6) An ongoing focus in the lab is to identify the signals induced by GITR and 4-1BB to sustain T cell activation, so that we can understand the unique and overlapping features of these costimulatory pathways.
Another area of interest is the role of TNFR family members in tissue resident memory T cells (Trm). Trm persist in the tissues after clearance of infection to provide a first line of defense upon re-infection. Our recent results show that 4-1BB is critical for the formation lung resident memory CD8 T cells (Trm) and that inclusion of 4-1BBL into a vaccine vector delivered intranasally greatly enhances the establishment of the Trm population and its persistence (7). We are currently investigating the mechanisms by which 4-1BB contributes to Trm formation.
My laboratory has a strong interest in T cell immunity in humans, with an emphasis on influenza and HIV. For example, we explored the state of T cell memory to influenza virus in older people and found that the memory CD8 T cells expressed markers of terminal differentiation and senescence commonly found in T cells specific for persisting pathogens such as CMV (8). We also examined the state of immunity to A/2009 pandemic influenza in the Toronto population at 1 year post-pandemic (9).
Another aspect of our work has been to investigate the role of TNFR associated factors (TRAFs) in TNFR signaling and human disease. TRAF1 has diverse roles in biology; it is a critical positive regulator of 4-1BB signaling, (10) however, it can negatively regulate TLR signaling to limit inflammation (11) TRAF1 is also expressed in human lymphoma and chronic lymphocytic leukemia and an ongoing project in the lab involves a therapeutic approach to lower TRAF1 levels in cancer cells.
Our research is funded by a Canadian Institutes for Health Foundation Grant.


text:
Dragon Drive is published by Viz as part of the Shonen Jump line. Current price is $7.99 per volume.
Publication DatesEdit
Last IssueEdit
- Dragon Drive, vol. 13: 15 Apr 2009
Current IssueEdit
- Dragon Drive, vol. 14: 10 Jun 2009
Next IssueEdit
- none
Bimonthly. Tankōbon. Scheduled for fourteen volumes.
Main CharactersEdit
- Reiji ozora
- Maiko yukino
- Hagiwara daisuke
- kohei toki
- hikaru himuro
- Ichiro Sumishiba
Dragon CharactersEdit
- Chibi ( Senkokura )
- Gorao
- Thunderbolt
- koukaoh
- kohbaku kon-oh
- Canopus
- Dov aqua
- gilo babi
- babi ngepet
- cacad
- tong sampah
Other Characters/Places/ThingsEdit
Recent StorylinesEdit
Dragon Drive, vol. 14 Edit
This is the current volume, and therefore no story information will be posted about this issue. Please check your local comic shop for copies of this issue.
Dragon Drive, vol. 13 Edit
Dragon Drive, vol. 12 Edit
Dragon Drive, vol. 11 Edit
Dragon Drive, vol. 10 Edit
Dragon Drive, vol. 9 Edit
Dragon Drive, vol. 8 Edit
Dragon Drive, vol. 7 Edit
Dragon Drive, vol. 6 Edit
Dragon Drive, vol. 5 Edit
Dragon Drive, vol. 4 Edit
Dragon Drive, vol. 3 Edit
Dragon Drive, vol. 2 Edit
Dragon Drive, vol. 1 Edit
Past StorylinesEdit
Leftover Useful InformationEdit
Creative TeamEdit
Created, Written and Drawn by Ken-ichi Sakura.
Publishing HistoryEdit
First published in Japan as Dragon Drive (ドラゴンドライブ) from 2001–2006 in the anthology Shonen Jump.
First English-language translation published by Viz in 2007.
Order CodesEdit
These are the order codes and prices as provided by Diamond Distribution. Your local comic shop should be able to order these for you.
Future Publication DatesEdit
Dates subject to change at the whims of the publisher or distributor. Please see the Diamond Shipping Lists for current information.
- Dragon Drive, vol. 14: 03 Jun 2009
- Viz, LLC - Publisher's Website
- wikipedia:Dragon Drive

subset: commoncrawl


text:
Joshua Hutcheson is a graduate student in the Biomedical Engineering Department at the University of Arkansas. He is part of the research team at the University's Translational Biophotonics & Imaging Lab, and a member of the UArk Biomedical Engineering Society.
UArk BME: Have you always wanted to be an Engineer? What attracts you to Biomedical Engineering specifically?
Hutcheson: Growing up I actually wanted to be a doctor. I went into the program pre-med with engineering as a fallback, and it has proven to be a good one! I chose engineering graduate school for a lot of reasons but one in particular is that I think Biomedical Engineers are going to have a major role in primary care in the coming decade due to the modernization of medicine.
UArk BME: Recently, your research work was published in Review of Scientific Instruments. Can you discuss in layman's terms what you reported in your paper, "A widefield fluorescence microscope with a linear image sensor for image cytometry of biospecimens: Considerations for image quality optimization" ?
Hutcheson: I would be happy to! To begin, we built a microscope with a line scan camera for fast, seamless image processing. A line scan camera takes pictures of objects lines at a time, as they are translated by the image sensor, and the advantage to that is that it can transfer smaller amounts of data (i.e. the picture) at a time. We then wrote a code to recombine the individual lines into a cohesive image on the computer.
The problem confronted in this paper was that there has to be a synchronization in the translation speed of the objects and the camera's acquisition rate (how fast it takes pictures). After we presented adequate data towards that problem, we showed that the speed of this system has promising applications in the field of image cytometry. This is a research topic that uses images to classify and count large amounts of biological specimens.
UArk BME: What's next in your research?
Hutcheson: Great question, I was actually working on the next project before that last paper cleared peer-review! We have been developing a collaboration with Dr. Ingrid Fritsch's group in Chemistry/Biochemistry, in particular with the project of Foysal Khan, one of her graduate students. His project is a microfluidic device driven by magnetohydrodynamic (MHD) fluid flow. In layman's terms, it's a small chamber that uses magnetic force and chemical ions to control fluid flow, and we have been working on a paper to show that they can control the speed of fluid in their device to synchronize with our camera just like in the previous paper. We just submitted a patent application on the combination of these two technologies, and I got accepted to present our results in San Francisco at the beginning of next semester.
I have also made some ground on another project of late, which we call, "whole slide scanning". This project has been hugely accelerated by the outstanding work of one of my undergraduate researchers, Courtney Hunter. She just started this semester and has really taken off, and we actually just found out that Courtney has been awarded a SURF grant to work on whole slide scanning for the next year as a part of her thesis work under my supervision—exciting stuff! In short, whole slide scanning is a way to rapidly image a slide for pathological analysis; this project is going to hopefully be used to better enable clinical pathologists to streamline routine diagnostic tests.
UArk BME: Earlier this year, you had the chance to present some of your research work at the 2015 SPIE Photonics West Conference in San Francisco. What was the best part of being able to attend this conference? Did anything surprise you?
Hutcheson: I did! It was a great time, and I was really grateful for the opportunity! Apart from just being in San Francisco (it was my first time), I think the best part was gaining the understanding that what I do in the lab, day after day, actually does have a place in the world of research. Sometimes, as a new researcher, it is easy to lose sight of the application of your project, and I feel that wrapping everything up and presenting a finished product helps the researcher have a healthy perspective on that.
With regard to what surprised me, the conference was pretty huge (San Francisco is a bit different from Fayetteville), so I was trying to get my bearings most of the time. One thing I did learn is that research is a very interconnected field. Dr. Muldoon introduced us to a lot of people that he has met and worked with during his career, which really benefits us (the graduate students) and is a great model for our own future career development.
UArk BME: What's it been like to work with Dr. Timothy Muldoon (the principal investigator of the Translational Biophotonics and Imaging Laboratory)? In what ways has he helped you in your research/career?
Hutcheson: I could go on for a while about the supervision, mentoring, and research skills of Dr. Muldoon. If you have ever worked with Tim or taken one of his classes, you will probably find out that he is neurotic about email (in the best way possible, though!). He rarely goes a few hours without checking and replying to every unread email, and if he finds out that one of the graduate students has made contact with an outside connection (i.e. a supplier, collaborator, clinician, etc.) without him on the chain, then you will (promptly) be getting another email! I say this to demonstrate just how present and involved he is as a mentor, and how impeccable his communication skills are.
On a personal level, he has helped me immensely with my scientific speaking and writing skills. He is not only focused on the research deadlines, but on developing his graduate students so that we are able to successfully transition into our next positions. We also end most meetings with some time to hang out and talk, whether it be about classes, interpersonal relationships, or just what we are doing that weekend.
UArk BME: More broadly speaking, what makes being a Biomedical Engineering at the U. of A. different than being one elsewhere? What sets this program apart?
Hutcheson: As most know, our program is very new, and I think what some consider to be a weakness is actually our greatest strength. In the beginning stages of a program, there's a lot that has to be set up, including IRB protocols, instrument facilities, etc. The upside to this is that the graduate students in this program get intimate exposure to how everything works, and the start-up process of the program's infrastructure. In contrast, a graduate student who walks into a project that has been passed along for the last 10 years initially does not know how to troubleshoot when things go wrong. In contrast, if you build something with your own hands, you know what to do when it breaks. Therefore, I feel that the newness of the program makes our graduate students highly competitive candidates on the job market after they graduate. I would encourage any current or future graduate students of this program who are reading this to think long and hard about how to communicate your usefulness, in this way, to your future employers.
Another benefit of our program are the professors. When searching for new faculty, the core faculty here makes it a point to bring together candidates that will fit in well with the culture. In a more high-profile program, you will not particularly have this benefit, because they are focused more on solely bringing in the researchers with the biggest grants and the best publications. This isn't to say that we aren't bringing in top talent; actually, it's quite the opposite. Our staff's curriculum vitae represent some of the top research programs in the country, including The Johns Hopkins, Rice University, Georgia Tech, Duke, and Tufts, to name a few. Though these credentials are important, I appreciate the fact that this program also values culture. I feel confident that this is a place where researchers enjoy their work, and a department with whom outside departments enjoy collaborating.
UArk BME: As a member of the Biomedical Engineering Society (BMES) at the University, how important do you believe it is to bring in outside speakers to the Department, as BMES often does? Have any speakers you've seen been particularly influential, and/or do you have a dream speaker you'd love to bring to campus?
Hutcheson: This is huge! A speaker gives exposure and stimulates collaboration amongst the labs. One presentation by Ben Noe and Sara Muldoon from Medtronic and St. Jude, respectively, comes to mind. These speakers were brought by the BMES, and I felt that their presentation answered a lot of questions that those of us in the BME program had. Ben Noe is the contact for the national BMES committee on academia to industry translation; in short, he helps graduating students get noticed by engineering firms. I felt that their presentation was very practical, and a way for students to build valuable contacts in the industry world.
A dream speaker of mine would have to be Elon Musk, founder of Paypal, CEO of Tesla motors, CEO and Founder of SpaceX, and majority shareholder in SolarCity. This recommendation is purely selfish, as I just finished his biography, Elon Musk: Tesla, SpaceX, and the quest for a fantastic future by Ashlee Vance. I would highly recommend this book to any engineer.
Though Elon is a "rough around the edges" public figure, he has absolutely stimulated my desire as an engineer to innovate in ways that are useful, and create new products that hugely impact the world. He challenges the supposed "brilliance" of products like Netflix (which encourages laziness) by disrupting the car industry, banking moguls, and the bureaucratic space industry; these disrupting technologies have flipped markets upside-down and challenged engineers not to waste their time and intelligence on useless products, but rather on truly changing the world.
UArk BME: You're also a Teaching Assistant at the University, and have been for several semesters now. Is there anything you've learned from this experience that you perhaps didn't expect?
Hutcheson: Absolutely. Being a teaching assistant can be pretty difficult for graduate students sometimes, but it's also seen as a "right-of-passage" of sorts. At first, I didn't enjoy it much and saw it more as a graduation requirement. This semester has been significantly different than my other one, and I've actually learned that I like to teach a lot more when I inherently understand the topic. At present, I teach a lab for the Biomedical Signals and Systems class taught by Dr. Narasimhan Rajaram; this lab is based in a high- level coding software called MATLAB and we mostly work on signal processing. I've really enjoyed helping the undergraduate students understand how to use MATLAB for their benefit, and I hope they've learned enough from me that they can use it in the future.
UArk BME: What advice would you give to an undergraduate engineer considering grad school? Any benefits you'd care to highlight?
Hutcheson: There's so much to say here, but I will try and stay brief. If you are considering graduate school then I would say that you absolutely need to start as an undergraduate researcher. It will give you a phenomenal start into understanding the inner workings of academic research.
Moreover, if you are considering the choice between medical school and engineering graduate school, I would encourage you to take a serious look at the current industry as it pertains to health care and the future of primary care. I would by no means discourage a student going to medical school if that is truly what they want to do, but I would highly encourage students to be educated about present jobs on the market, and to get sufficient advice from other doctors, professors, and mentors about the future of the industry. Don't simply continue to pursue medical school because it's why you came to college in the first place. Personally, I believe that there will always be a place for doctors and there is an unbelievable market for specialists, but biomedical engineers and technologically driven health care will have an undeniably bigger role in primary care in our lifetime.
In general, whichever direction you go, it's important to be educated on the future of that industry; you need to take stock from all aspects. Don't keep your head down and focus solely on good grades, test scores, and recommendations; be sure to also analyze critically where healthcare is going, how the leading politicians will litigate, and what firms will influence the world's resources the most.
UArk BME: A Biomedical Engineer learns she is going to be stranded on a deserted island, and will be allowed to bring only three items with her. What does she bring?
Hutcheson: I probably won't answer this like the typical engineer!* I automatically thought, "Well how long? Do items include people? Do I know for certain if there's food?" Anyways, I will answer this to the best of my ability. If I can bring people, my three things would be my Bible, my wife, and a knife. If I can't bring people, then my Bible, a knife and a fishing rod.
*I'm also assuming you didn't want answers like GPS tracker so people can find me! I figured I'd play along rather than cheating.


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Thanks to the many RSS feeds on technology that I read, I now chance upon this awesome unboxing video of the much hyped about Google Superphone – Nexus One.
This is one of the (no, scrap that) THE BEST unboxing video that I have ever seen. Awesomely executed with mini ninja's on motion capture style, this is one you don't want to miss.
Even if you're not a Nexus One fan.


text:
Coming home after a long day at work and realizing that you still need to clean the house in order to make it presentable to the friends that you have coming over, is something that most of us face on a regular basis. If you have kids, you know that there can be quite a lot of dirt on the floors and you need to clean it on a daily basis almost. If you have pets, you know the pet hair is everywhere, and it can be hard to get rid of even if you try really hard. The solution for this problem is a robot vacuum cleaner.
The vacuum cleaning robot iRobot Roomba 760 has been designed to make your life easier, and at the same time bring you a better cleaning result than what you would get doing it by hand. A better result? Really? How come?
Well most of the time when you are vacuum cleaning the house, you are using a stand up vacuum cleaner which you are pushing around the floors. It's great but the problem is that you are not really close to the floor to see if you got everything already, and you can't easily use it under the furniture. If you are not always moving your sofas and beds when you are doing the cleaning, you are not getting everything from under there. Also if you don't carefully look at the floor from close up, you won't see if you really got everything. The vacuum cleaning robot will do the work for you, and monitor the cleanliness of the floor while it is cleaning, to make sure that it got everything. The iRobot 760 Roomba will spend more time in areas which need more cleaning, and it will move in a back and forth style until it gets everything there is to get. The brushes will penetrate deep in your carpets and make sure that they lift all the pet hair and dirt from deep in the fibers, while the vacuum cleaner is picking them up along with the two counter rotating brushes which act like a dustbin and a brush.
The robot works with a battery which is charged every time it returns to the home base, or docking station, after it is done cleaning the house or when the battery is running low. It can do up to four rooms with a single charge, and it will do all completely automatically. You might want to do some preparations in the rooms if you have a lot of things on the floors - it will not move the possible objects on the floor, but instead it will just go around them.
If you are not convinced about the effectiveness of vacuum cleaning robots such as the Roomba 760, have a look at the video below to see it in action!


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Grantsdale, Montana is an unincorporated community in Ravalli County. It is located near U.S. 93 and Montana (Skalkaho) Highway approximately 3 miles south of Hamilton.
Grantsdale was founded by Henry H. Grant whose family traced their ancestry to General Ulysses S. Grant. Henry Grant came to the Bitterroot Valley in 1884, to a 160-acre farm on Willow Creek, east of Corvallis. Later he sold that land and moved to the Skalkaho area where he purchased a mill and several hundred acres of land. He remodeled the mill and produced quality flour with the brand name of "Home Favorite."
In 1885, the town was surveyed and platted, at the request of H.H. Grant, and thereafter the town was known as Grantsdale.
Description Provided by rootsweb.ancestry.com


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The Indiana State Police is testing a new Web app to assist with school bus inspections that are mandated by the state and federal government.
The Indiana State Police is beta testing a new Web app to help streamline school bus inspections in the state.
Each year, Indiana inspects "school and activity purpose" buses, about 17,000 vehicles in all. For buses that are more than 12 years old, inspections are completed twice a year. The inspections, conducted by 19 officers throughout the state, help to ensure that the condition of a bus's various parts meet state and federal safety regulations, said Sgt. Steve Whitaker of the Indiana State Police.
In years past, the troopers responsible for conducting inspections did so by marking off a checklist on paper forms, and then manually re-entered the checklist into a database, Whitaker said. The paper-based process was cumbersome, Whitaker said, because Indiana requires that bus inspections start in January and are completed by the end of September.
So to reduce officer staff hours dedicated to inspections and streamline the inspection process, the Indiana State Police began working in July 2010 with a computer class at IUPUI — Indiana University, Purdue University Indianapolis.
"The class took it on as a project," Whitaker said. "We got picked, and they worked through this for a semester and identified a lot of things, and set the stage."
The class came up with the idea of a Web app for bus inspections, which the state police then presented in December to Indiana Interactive, the subsidiary of e-government provider NIC USA, which manages the state's Web services.
Although the app is still in the pilot stage, Whitaker said it is operational and now in use by the 19 officers throughout Indiana who are responsible for the bus inspections.
To better suit the officers' needs, the app was developed to run on BlackBerry PlayBook tablets, said Sloane Wright, general manager of Indiana Interactive. Through a collaborative effort among the Indiana State Police, Indiana Interactive and the Indiana Office of Technology, the three entities were able to help secure grant funding so that each of the 19 inspectors could get a tablet, which they received in December.
"All of these inspectors are utilizing the system, and they've put the paper system in their trunks," Wright said. "We're just trying to make sure we've worked through all of the scenarios and use cases that we may want to add or enhance. We've approached this as a living, breathing thing."
The app digitized the inspection checklist, but it also functions as a dashboard indicating which officer is doing what inspections. Buses that don't pass on the first inspection must be re-inspected on a later date, so information regarding a bus's failed inspection also is logged in the system.
"If a bus is marked as 'rejected' or 'out of service,' different timelines are associated with that bus when they have to be revisited and relooked at," Wright said. "So now the system does that automatically for them."
Through the dashboard, officers can see when other officers need assistance, or if fellow officers are out sick or on vacation. The dashboard can help the officers coordinate, Wright said.
Whitaker will soon have on-demand access to the data that's inputted. Users will be able to break down the data into categories such as school districts, schools and model year of the bus, Wright said.
For better tracking, the state police built quick response (QR) code functionality into the application. QR codes are black and white matrix-shaped surfaces that can be scanned. The state police is in the process of attaching QR codes to each of the buses, which are then tracked through the app. Whitaker said by Sept. 30, all buses that get inspected by the police will have to be affixed with a QR code.
Although the state hasn't determined yet what the ROI will be for the new inspection system, Whitaker said he expects the state will realize significant savings in reduced paper and staff time costs.
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Declaration of UN's 75th anniversary urges global unity
The world's often-divided nations united Monday to adopt a declaration commemorating the 75th anniversary of the United Nations, saying the urgency for all countries to come together "has rarely been greater" amid global challenges ranging from the coronavirus pandemic to climate change and violent extremism.
The declaration, approved by 193 member nations at the mainly virtual commemoration, praises the United Nations as the only global organization with the power to bring countries together and give "hope to so many people for a better world and ... deliver the future we want."
Born out of the horrors of World War II, the United Nations was established to save succeeding generations from the scourge of war — words enshrined in the U.N. Charter.
The declaration recalls the U.N.'s successes and failures over more than seven decades and vows to build a post-pandemic world that is more equal, works together and protects the planet.
Even at times of great tension, the declaration says, the U.N. promoted decolonization, freedom, development, human rights and equality, "and worked to eradicate disease." And it "helped mitigate dozens of conflicts, saved hundreds of thousands of lives through humanitarian action and provided millions of children with the education that every child deserves."
As for disappointments, the declaration says the world "is plagued by growing inequality, poverty, hunger, armed conflicts, terrorism, insecurity, climate change and pandemics." It says the poorest and least developed countries are falling behind, decolonization is not complete and people are forced to make dangerous journeys in search of refuge.
"Our challenges are interconnected and can only be addressed through reinvigorated multilateralism," it says.
The declaration stresses that the commemoration is taking place as the pandemic reverberates, not only causing death and serious illness but "global economic recession, increased poverty, anxiety and fear."
"The COVID-19 pandemic has reminded us in the most powerful way that we are closely interconnected and only as strong as our weakest link," it says.
Only by working together can the pandemic end and "only together can we build resilience against future pandemics and other global challenges," the declaration says.
"Multilateralism is not an option but a necessity as we build back better for a more equal, more resilient and more sustainable world," it says. "The United Nations must be at the center of our efforts."
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Another injury has hit a So You Think You Can Dance contestant.
Ashley Galvan experienced rib pains during rehearsals Monday and had to sit out Wednesday's performance show, during which she was set to dance two different numbers with Robert Roldan and Pasha Kovalev.
So You Think You Can Dance's Alex Wong eliminated due to lacerated Achilles tendon
Glavan automatically was placed into the bottom three, as was the case with Alex Wong, who was sidelined from the competition last week when he lacerated his Achilles tendon.
If Galvan is eliminated, that leaves one woman, Lauren Froderman, in the running for America's favorite dancer.


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Phone: 573-777-4800
About Us
Zettler Construction is locally owned and operated in Columbia, MO. We are a full service construction company for the entire Mid-Missouri area specializing in Heating & Air Conditioning.
Heating & Cooling
Whether you're building your dream home or updating the system in your current home, Zettler Construction will provide you with the best quality work on all components of your HV/AC system. Zettler Construction is experienced in installing and servicing all brands of furnaces, heat pumps, air conditioners and coils.
We offer services ranging from diagnosing existing problems to routine maintenance and everything in between. Zettler Construction also offers their customers, convenient 24-hour service. If your system needs repair on Sunday or after 5 p.m., call us and we'll be there.
General Contracting
Zettler Construction has more than a decade of experience in the construction industry. We have strong relationships with various local experts in all areas of the industry. We can handle all of your general contracting needs from basement finishes to total housing, let us exceed your expectations.
Construction & Handyman
Whatever you need, Zettler Construction can get it done! We are well equipped to take care of any job – light electrical and plumbing, appliance service and installation, flooring, drywall, paint, trim, door and window install, and more. If you have a list of home improvement projects, give it to us and consider it done. No job is too big or small.
Click any photo below to get a larger view or view the slideshow.


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Conquer Your Fear of Public Speaking With Better Body Language
Project 5 of the Competent Communication Manual
Toastmasters is one of the best ways to learn public speaking. In Toastmasters clubs worldwide, members follow a set program to improve their communication and leadership skills. The first public speaking guide you receive when you become a member of Toastmasters is the Competent Communication manual. The CC manual goes over various basic aspects of public speaking - such as vocal variety, visual aids, and speech organization. Project 5, Your Body Speaks, goes over one of the most essential aspects of public speaking - body language. This article contains some advice to help with this speech project - both for Toastmasters, and for public speaking in general.
Read Up On Reading Body Language
For "Your Body Speaks", the first step would be to look up resources on how to read body language. My personal favorite body language book is What Every Body is Saying by Joe Navarro, a former FBI investigator who is an expert on the subject. The book goes into great detail about the psychology behind body language, what certain gestures say, and how to interpret people's gestures.
Your Toastmasters Competent Communication manual will also contain some good information on the Your Body Speaks project page - though it tends to be a bit broad and doesn't go into a lot of detail. Another excellent book is The Art of Public Speaking by Dale Carnegie; while it's not specifically about body language, it does contain a lot of great tips for that and other aspects of public speaking.
Keep Your Hands Where I Can See Them - Hand Gestures
Hand gestures are very important when it comes to your stage presence. People are hard wired to notice people's hand movements, and in any presentation people will pay a lot of attention to your hands. In general, you want to avoid closed gestures, and keep your hands VISIBLE with a reasonable amount of movement. Body gestures that put a distance between you and your audience - such as crossed arms - are something you want to avoid. Gestures that imply an air of superiority over your audience - such as putting your arms behind your back in a "pensive" gesture - are also not recommended.
Putting your hands to your waist in an aggressive or authoritarian way - arms akimbo - is more threatening than authoritative for your audience. Also be careful about pacifying behaviors - that is, things like touching your head nervously, holding and rubbing your hands together. These are clear signs of nervousness that will detract from your stage presence and message you want to present.
Depending on the style of your Toastmasters presentation - whether it's a humorous, serious, or informative speech - the style of hand gestures and movement are obviously going to vary. Toastmasters members tend to think that you always have to use exaggerated movements, but this isn't the case. For my project, I gave a humorous speech where I talked about my work teaching children in Asia, so exaggeration was definitely appropriate. However you can also impress with more subtle, understated gestures.
Conquer Your Fear - Movement and the Fight or Flight Response
Movement is one of the most important things to learn in Toastmasters. Standing completely still during the "Your Body Speaks" project makes you look nervous, no matter how good your body language is otherwise. Moving too much will have the same effect - I've seen Toastmasters speeches where speakers pace nervously back and forth across the stage. The reason is simple - both make it look like you're in fight or flight mode. As an instinctive reaction to danger, people tend to first freeze, then run away, then fight (if necessary). An excess of stillness or movement is going to make your audience think you're incredibly scared.
So don't be afraid to walk around the stage a little, so long as you're not going overboard. An excellent and easy tip to implement is this -walk to a different part of the stage as you transition to a new point. This serves as a visual exclamation mark of sorts, and helps to hold your audience's attention.
Involve Your Audience with Eye Contact
Eye contact is a simple thing to talk about, but in practice it can be one of the hardest things for a new Toastmasters member. Like with hand gestures and movement, people often tend towards extremes when looking at the audience. Some do not make eye contact at all. Some have a bad habit of practically staring at one side of the audience - making a large portion of your listeners feel unincluded. Like with a lot of things involved in giving presentations, eye contact requires a balancing act. Make sure you're giving your whole audience attention, periodically changing your view in order to make everyone feel involved.
Body Language with Visual Aids
Giving a speech with a good Powerpoint Presentation can add a lot to your public speaking. (A later project in your Competent Communication manual is about visual aids). When you're using visual aids, however, there are few things to keep in mind.
First off, make sure you are not looking at your Powerpoint too much. This is an easy habit for beginning Toastmasters to get into, but it creates a distance between you and your audience, and makes you look nervous. Secondly, make sure you're not standing in front of the projection screen. It sounds like an easy thing, but I've seen too many speeches where the speaker is standing in front of the screen, thus blocking people's view. It ends up looking very awkward.
Finally, when using visual aids, much of your movement across the stage is obviously restricted. So instead of movement, you'll have to rely more on other aspects of body language, like hand gestures.
The Toastmasters Competent Communication Manual teaches you the basics of public speaking. While much of learning about giving presentations involves learning as you go, it can help to have some useful advice to guide you along. Using some of the tips outlined above, you can improve your body language significantly.
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Nor did the mayor hesitate or ask for an explanation when he demanded Dixons resignation two weeks ago, after Dixon was indicted along with John Ford and four other current and former state legislators in Operation Tennessee Waltz.
The ripple effect of the indictment of Uncle John on U.S. representative Harold Ford Jr.s Senate campaign has drawn a lot of media attention, but what does Dixons indictment say about him and Wharton? Dixon is charged with extorting $9,500 from the FBIs sham company E-Cycle Management in 2004, his last year in the Tennessee Senate. He served a combined 22 years in the Senate and House. His record was scandal-free but hardly distinguished. Tellingly, in the Tennessee Blue Book he listed his occupation as consultant. The only other self-described consultant among the 33 senators: John Ford.
The biggest negative when I hired Roscoe was that for the first time in his life he was going to have a real job, Wharton said in an interview Monday.
Wharton did not do a background check before hiring Dixon but did have someone question lobbyists and other lawmakers about him. The reports, Wharton said, were that Dixon was not a superstar, just a good old plodder, someone who would just chug along, which was what I needed in that position. The FBI knew better. Undercover agents had already made payoffs to Dixon through his bag man, Barry Myers, several months before Wharton hired Dixon. But the stakes were too high for anyone to tell the mayor.
Wharton, formerly a criminal defense attorney, said he had a pretty good inkling that something was going to happen two weeks before it did from some of his old colleagues. But he did not know who would be indicted. He demanded and got Dixons resignation the same day he was indicted and has not spoken to him about the case since then.
An in-house investigation has so far determined that Dixon did absolutely no business for E-Cycle with county government, Wharton said. Shelby County commissioner Michael Hooks, while admitting no wrongdoing, has acknowledged helping E-Cycle make a belated bid for county business earlier this year after Dixon was aboard. The indictment says Dixon and Myers conspired to help E-Cycle beginning on or about July 30, 2004 and continuing thereafter until on or about May 20, 2005.
As portrayed in the indictment, Dixon lives down to his reputation. He insists that his payments go through Myers. He files a bill to benefit E-Cycle in January 2004, but the details arent right so he indicated to an individual that he wished to have faxed to his office the bill which was desired by E-Cycle. When E-Cycle asks to have the bill withdrawn in March, Dixon doesnt get that right either, and he has to be asked what E-Cycle was paying him for before dutifully pulling the bill a week later.
Such is the man Wharton hired nine months later for a job paying $101,000 a year.
Between greeting constituents and drinking his breakfast orange juice at a Burger King this week, Wharton wondered how deeply the corruption runs.
I just came out of a grueling session with the legislature, he said. Sometimes when I was talking one-on-one it just seemed like they werent hearing, like there was an impenetrable wall between the two of us. I kept wondering, What am I missing here? Im not saying they did not pass my bill because they were on the take. I am just saying this kind of thing will cause people to wonder if legislation passed that would not have passed or if there were good bills that should have passed that did not.
A cloud hangs over the Shelby County Commission as well, with the possible double-whammy of more Tennessee Waltz indictments and an upcoming tell-all book by former chief administrator Calvin Williams.
Asked about that, Wharton who is unflappable and about as impossible not to like as a politician can be glanced up at a passing airplane and responded with a vintage Whartonism. Theres a headwind, but sometimes thats good because it allows you to get your plane up. Maybe we will have to work harder now. It may be a blessing in disguise.
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What is your name and relationship to the oil industry?
My name is Paul Munding, and I am the Vice President of Petroleum Engineering at Flogistix. I have over 15 years of experience in the industry. Ten of those years were spent at Chesapeake, with three years in the reservoir department in the Permian Basin and seven years with completions and production duties across the Mid-Continent. I then worked at RKI/WPX, as the production engineering manager over the Delaware Basin asset. I joined the Flogistix team in April of 2016 to start a petroleum engineering department that helps operators focus on solutions using Flogistix equipment and expertise. Working in production over the last ten years, I have seen the need for advancements in production technology that can help the production engineer manage wells more efficiently. Flogistix has the technology to address a wide spectrum of production issue: unloading marginal gas wells, improving production of artificial lift methods, and vapor recovery.
What is the history of Flogistix, and how did it get involved in unconventional plays, including shale plays?
Flogistix acquired Fluid Compressor Partners in 2011. Fluid Compressor Partners had a history dating back to 1996 that included building liquid rings for the Raton Basin and Texas panhandle fields in the Hugoton Basin. In the 2000s, screw compressors gradually became the preference as greater discharge pressure could be achieved at the same suction as liquid rings. They introduced programmable logic controllers (PLC) to control gas engine drive compressors in 2007. In late 2009, Fluid Compressor began using screw compressors in vapor recovery applications. After acquiring Fluid Compressor, Flogistix invested knowledge in vapor recovery application technology. With this new knowledge, the PLC was tailored to control the compressor while measuring vapor amounts in ounces at the stock tank or vapor recovery tower (VRT).
With the advanced controls geared towards vapor recovery, Flogistix was a good fit for the capture of vapors associated with the Niobrara wells of the DJ Basin. This basin became very active by 2011, as more operators extended the play out in Weld County, Colorado. The Niobrara wells produce high gravity oil along with wet gas. The wet gas is composed of raw natural gas (primarily CH4) and natural gas liquids (NGL). These NGLs are the gaseous components consisting of ethane, propane, butane, pentane, and heavier molecular weight hydrocarbons (HC). Pentane and higher molecular HC are considered condensate. As the wells produce fluids to the surface, cooling takes place allowing the condensate components to drop out of the wet gas in primary separators at high pressure slightly above gathering line pressure. The condensate and oil will then often go to a vapor recovery tower or stock tank where pressure is near atmosphere, allowing gases to flash off the liquid as vapors. The gas vapors captured in these towers is very rich in NGLs, with as high as 3200 MBTU content observed per MCF. The gas flashed at low pressure is unable to get into the high pressure sales gathering line and this is where the Flogistix screw compressor is utilized. It will pull the vapors off of the VRT or stock tanks depending on the design of the facility and boost them into the sales line. Our compressors are a good fit for this application since they can pull towers down to ounces and can discharge as high as 365 psig. By year end of 2013, Flogistix had become the preferred vapor recovery vendor in the DJ Basin. Flogistix has now taken this knowledge achieved to apply to their installs in the other unconventional basins of the Eagleford, Permian, and Anadarko.
What kind of equipment does Flogistix specialize in, and how is it used in wells in shales and unconventionals?
Flogistix manufactures screw compressor packages primarily to fit vapor recovery and wellhead applications. In addition to vapor recovery, as explained earlier, the compressor can do multiple roles for wells by reducing flowing wellhead pressures. With unconventional wells this is often in the form of assisting artificial lift methods. This includes drawing the gas off of the casing to improve fluid flow up the Tbg in ESP and sucker rod applications. Downhole pumps are not meant to handle large amounts of gas and become very inefficient as gas percentage increases. By pulling the pressure on the casing down, it allows gas to vent up the casing annulus. The downhole pump can then ingest primarily fluid and increase production on the well. The life of the equipment is significantly improved and can mean the savings of hundreds of thousands of dollars in failed pump expenses due to gas handling. Flogistix recently set a compressor doing a casing drawdown of an ESP in the Anadarko basin. It was a success and the operator was able to prolong the life of their ESP equipment. Look for this case study to be published soon with more details.
Plunger lift is another form of lift that our compressors can be utilized to assist for unconventional WH applications. As unconventional gas wells decline, they lose bottomhole pressure and continue to need larger buildup of differential pressure across their casing and tubing string to raise a plunger to surface. By setting our compressor on the Tbg, we can lower the surface pressure that the plunger has to rise against and effectively reduce the differential pressure needed to make a trip. This in turn allows the plunger to make more trips per day. Through our own developed Logix PLC panel, the skid manages control of the compressor by monitoring the pressure upstream of the suction side. Flogisitix compressors have managed as many as four wells on one Pad in a plunger assist application. Operators in the DJ Basin have successfully used this process to achieve as high as 80% increases in production. One such operator has now made it a standard practice across the basin for their operations.
There are tough new methane emission standards. How does Flogistix equipment help prevent fugitive methane emissions?
Flogistix works with operators in planning their facilites from the beginning. This is an important step to make sure facilities are sized to handle not just daily production, but instantaneous slug rates at the vessels. Proper sizing of pipe and routing is also crucial to deliver the maximum obtainable capture of the flash gas. The flexibility of Flogistix equipment allows for vapor recovery and WH assist solutions for the life of a well. An operator can capture vapors over time at lower volumes of production by adjusting the control set point of the compressor on the Logix PLC. The VRT allows the operator to bring this setpoint down to two ounces and lower versus the six ounce minimum threshold on most stock tanks.
If a well has declined in flash gas volume to the point where spare capacity is available on the compressor, then the MultistreamTM function can be used on the Logix PLC to let the compressor collect gas from two different sources. For instance, an operator could begin to pull gas off of his csg to help his ESP as well as continue to capture vapors flashing off of their oil tanks, even at lower production rates. Despite these small rates, capturing fugitive emissions across thousands of wells can make up millions of cubic feet of gas, while also allowing the industry to be good stewards of the environment. Some operators choose to combust or flare their flash gas but improper operation of this equipment can lead to emissions of methane and VOCs, thus resulting in heavy fines. Proper operation of these control devices often gets overlooked with lease operators having multiple wells and lots of equipment to track. In the end, vapor recovery is the only solution that captures the energy rather than wasting it, while still keeping the regional air quality high for residents and animals.
What are some of Flogistix's new capabilities and areas of opportunities for operators who have new and existing oil and gas production?
We have several new products within our company that have us very excited for operators. One is our composite coil tubing (CCT) service that we offer. This CCT can be installed in older wells that have loaded up as velocity strings. The beauty of the installation is it can be done in a day, at half the cost of conventional steel coil and without all of the corrosion issues. The coil can be run inside Tbg and then easily hung off in the Tbg head with an adapter. Flow can then be up the insided diameter of the CT or the annulus between it and the Tbg. Gas could also be injected down this annulus to provide lift assistance for the well. Flogistix has already done several of these successful operations for horizontal wells in the Marcellus Shale of West Virginia. Most of these wells are three to five years old and are loading up in the 250-600 MCFD rates, with 400 psig line pressure. This application can also be done in the Barnett where line pressures run between 100-150 psig, with wells starting to load in the 100 – 250 MCFD range.
The other new product that is about to launch for Flogistix, is our intelligent gas lift compressor. The reciprocating compressor will be controlled by our own Logix PLC. It will use information given by the well to calculate the necessary injection rate to achieve the minimum bottom hole pressure (BHP), resulting in maximum acheivable well production. The Logix PLC will obtain the injection rate by varying speed and throttling its own automated suction control valve, while monitoring its own gas injection meter. This will allow the compressor to achieve the injection rate at the most efficient setting to burn less fuel gas and save more money for the operator as well. This compressor skid like all others in the Flogistix fleet, will have its diagnostics available to be seen live on FLUX. With FLUX, a customer has a secure webpage to view all of their unit's data live and up to the minute. All compressor data is stored for the length of the compressor set, allowing trends and predictive analysis be used to control the machine.
As one can see, Flogistix is always working to help operators look for new and cost effective ways to maximize their production and net revenue. We will work closely with any customer to develop and ensure our processes are as expected, and up to their standards.
Nash, Susan. "Improving Operations and Avoiding Methane Emissions: Interview with Paul Munding, Flogistix" Http://www.aapg.org. N.p., 24 July 2017. Web. 24 July 2017.


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Hunger, health, and society
Methods for evaluating the nutritional impact of food aid projects: lessons from past experience
Note for the record: comments on the paper ''methods for evaluating the nutritional impact of food aid projects: lessons from past experience'' by David Sahn
Strengthening developing-country institutions concerned with food and nutrition
Malnutrition in the 1980s: roles for the international agencies
Nutritional status and age at secondary sterility in rural Bangladesh
Anthropometry and nutritional status as a function of energy intake in children 0 to 19 years old in Bangladesh
Hunger, technology, and society
On-farm research and applied nutrition: some suggestions for collaboration between national institutes of nutrition and agricultural research
Economic aspects of food protein supplies in the world
News and notes
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Training programmes and courses
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