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Supervised Weight Management
Achieving a healthy weight can be a difficult and frustrating process. With so many similar diet and exercise options to choose from, finding one that will be helpful and safe for your goal can be overwhelming. Wherever you are in your weight management journey, a consultation can help clarify the road ahead.
At Tandem Clinic, our experienced naturopathic physicians create custom diet and lifestyle plans to help you not only achieve a healthy weight, but maintain that weight for good. Weekly visits with your doctor will ensure you stay on track and meet your health goals.
We offer 2 types of weight management programs:
Available Programs
6-Week Customized Weight Management Program:
- Initial visit with one of our Naturopathic Doctors:
- Comprehensive medical history & physical exam
- Starting weight & measurements
- Nutritional assessment
- Specific recommendations of vitamin, mineral, amino acid & anti-oxidant support as needed
- Customized diet & lifestyle plan
- Weekly Visits:
- 5 x 15 minute follow-up visits
- Health & progress tracking
- Weight & measurements
- Metabolic Boost vitamin injection for energy & metabolism (if indicated)
- Week 6 program performance review
Supervised Metabolic Weight Management
We offer 23 or 40-day medically supervised rapid weight loss programs for patients who want to lose a lot of weight in a short amount of time. The program involves daily injections of human chorionic gonadotropin (hCG), the pregnancy hormone, paired with a very strict diet. Patients who have completed our program have lost an average of 0.5 – 1 pounds per day*
How the Program Works
The program is typically twenty-six days in length but can extend up to forty-six days for patients needing to lose more than 30 pounds. hCG is said to help burn 'mobile fat', the fat stored around the hips, thighs, belly and upper arms, while leaving so-called 'structural fat' the fat that protects organs, untouched.
While maintaining a reduced-calorie diet with no fat intake, the body is forced to go after 'mobile fat' to burn for energy. Because hCG is an anabolic hormone by nature, it is said to prevent the muscle wasting that would normally occur during a low calorie diet.
Although hCG is not currently recognized by Health Canada as a weight loss tool, it has been shown to produce this result for many patients, reducing the feelings of hunger, weakness and irritability normally associated with a low calorie diet. You must see your doctor for weekly visits to monitor your progress, and ensure you are staying healthy and feeling well.
This program is for you if:
- You are ready to make significant lifestyle changes that include daily exercise, consuming more fruits, vegetables, lean proteins and healthy fats while avoiding refined food products, sugar and white flour.
- You must be ready and willing to address emotional triggers to unhealthy eating, emotional eating and food addiction cycles.
This program is not right for you if:
- You are not ready to commit to a strict calorie-reduced diet
- You prefer a less structured program or prefer more gradual weight loss
- You are not able to commit to weekly in-clinic visits
- You are pregnant
- You are or have breastfed a child in the last year
- You have a current or previous medical history that would prevent you from participating in this program*
Supervised Metabolic Weight Management Program:
- Initial visit with one of our Naturopathic Doctors:
- Comprehensive medical history to determine eligibility
- Initial weight & measurements
- hCG prescription*
- hCG diet & meal plan
- Follow-up Visits:
- 30 minute second visit to ensure your body is adjusting properly to the program
- 15 minute third & fourth visits
- 30 minute fifth visit to transition to the second phase of the program
- Health & progress tracking
- Weight & measurements
- Urine analysis
- Metabolic Boost vitamin injection (if indicated)
- Final week program performance review
*Results will depend on your adherence to the program and whether any underlying health issues are present. Your doctor will discuss any relevant history at your initial visit to determine your eligibility for this program. Prescription cost not included in program, it is usually around $100. Contact your medical insurance provider to determine if your medical plan will cover your prescription, most plans will.
Meet the Naturopathic Doctor
Our weight management programs are offered by Dr. Alaina Overton, ND.
Dr. Alaina Overton focuses in skin health & cosmetic dermatology. She has a passion for women's health, focusing on hormone imbalance, thyroid dysfunction, digestive issues, weight management, anxiety & depression. Dr. Overton also has a special interest in nutrition & IV nutrient therapy as well as celiac & gluten sensitivity. Services include annual health checks, laboratory & diagnostic testing, comprehensive health assessments and personalized health care programs.
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Motivate Your Team Intrinsically Or Extrinsically?July 21, 2011 - 5 minute read - Posted by Amin Palizban
There is no doubt that motivation is the driving force by which humans achieve their goals. Motivation can be intrinsic or extrinsic. Intrinsic motivation is driven by an interest or enjoyment in the actions required to achieve a goal, without relying on external rewards or pressures. Extrinsic motivation is the opposite and requires external rewards such as money or external consequences such as demotion.
Your team needs motivation. As a good leader should you enhance your team's motivation intrinsically or extrinsically?
Last week I discussed this top with Gordon Walter, who is an Organization Development expert and an adviser to 7Geese. In this blog post, I'm going to explain and compare the two different motivating forces, and also, suggest how is best to motivate your team.
Extrinsically motivating your team:
If you want to extrinsically motivate your team, you have to set group and individual goals and measure outcomes. You need to reward people that achieved their goals and you have to have consequences for underachiever which can be in the form of more training. Goal setting, getting employees motivated to achieve objectives, and recognizing them for their achievement is a proven method that pushes business forward and is one of the best examples of extrinsic motivation in a company. However, if you only attempt to extrinsically motivate your team, you will be faced with some difficulties.
Extrinsic motivation by itself (without intrinsic motivation) forces you to measure outputs (such as goal achievement and results) and pay little attention to the input (such as hard work and collaboration). It creates a dynamic where the top performers are motivated and the average employees get demotivated. It also can create a lone-wolf mentality where everyone is in it for themselves without helping or collaborating with others.
Intrinsically motivating your team:
If you want to intrinsically motivate your team, you have to create the conditions where your employees get turned on by doing the work they do. It's the rush they get when they perform the task and the internal satisfaction they get when they get the job done. Developing an intrinsically motivated team is not easy though. According to many HR experts, employees are more likely to be intrinsically motivated if the company has a compelling vision, clear objectives, and a supportive culture. It's also important that employees are a good fit for their position; i.e. they love using the skills needed to perform their duties and they have values in alignment with company core values.
Having an intrinsically motivated team is ideal; however, it is really hard to just relying on your team to be internally motivated. Without extrinsic drives such as goals and recognition, it is hard to turn the wheels of a business. Imagine a sales team without any sales goals or external recognition!
Combining intrinsic and extrinsic motivation is the solution
The most effective way to motivate your team is by enhancing both intrinsic and extrinsic motivating forces. These are some examples of how you can achieve this in your company:
- Create a compelling vision and set clear goals (extrinsic) and enhance your company culture and working conditions so employees love what they do and set their own goals (intrinsic)
- Recognize employees based on their outputs and achievements (extrinsic) and also on their inputs and behaviour such as collaboration that are in alignment with your company values (intrinsic)
Motivating people is one of the key skills of a good leader. It is important to understand the differences between intrinsic and extrinsic motivating forces, and learn to use them simultaneously to enhance your team or company's performance. One of the main focuses of our product, 7Geese, is to motivate knowledge workers and we have designed the product in a way that allows users to be both intrinsically and extrinsically motivated. In closing, it is important to mention that having motivated employees is not only beneficial to the company; it is also beneficial to the employee as motivation brings happiness and personal growth.motivation

subset: commoncrawl


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Kitchen Colors for 2020 One of my favorite places to visit for color inspiration is Design Seeds The beautifully curated color palettes are guaranteed to provoke interest and excitement. This is one of my favorite kitchen interior color palettes. It is interesting and sophisticated while still providing a neutral background: In keeping with this modern yet classic look, cabinet companies are now offering stunning stock colors, allowing us to design kitchens that impart that bespoke feeling: Looking forward to designing some amazing kitchens in … [Read more...]
Kitchens that Embrace the 2020 Color of the Year
In the Spotlight: Navy Navy Blue. Versatile. Classic. Adaptable. Navy has always been a Designer's favorite color for accents, accessories, and fabrics - now Navy is taking center stage! This is a collection of our favorite Navy Kitchens, in every style we love, from the freshest farmhouse to sleek and modern, and of course, traditional. We hope you will be inspired and emboldened! … [Read more...]
Creating Your Kitchen Color Palette
Congratulations on planning your new kitchen! Now you need to choose all your colors and patterns…. But where should you start? Work from the bottom up… Flooring First decision: the flooring. Keeping your existing floors? That was easy! We'd read some of these Select Home Warranty reviews and had gone with the platinum care plan, which also included flooring maintainance. However, we often see the need for new floors as one of the reasons for a remodel. And the flooring doesn't stop in the kitchen – this new material often runs throughout the first floor, and needs to coordinate with … [Read more...]
Introducing: The New Neutrals
Delightful New Designer Colors for Your Kitchen We have loved white painted kitchens for years now, and when we were feeling a little braver we switched to soft gray or warm cream tones. More and more Designers and homeowners have been turning to custom colors to create a personal and unique look. A look that is not identified with a "current trend". The cabinet companies are reacting to this desire with ever expanding offerings. Decorá Cabinets has expanded their Color Collection. Developed in tandem with Sherwin Williams, this offering of 30 colors is carefully curated for their … [Read more...]
Kitchen Design: Putting Together a Kitchen Color Palette
Colors and patterns – where to start? This article is a bit wordier than usual, but this topic can be complicated, and you can easily feel overwhelmed. Here are some of the ways we get the discussion headed in a productive direction. We suggest that you start collecting pictures, and put together an inspiration folder. This helps us identify the elements that appeal to your personal taste. Once we determine the vision you have for your kitchen, we can help you put together a cohesive palette. Bring in samples of any existing materials that we are working with (like flooring … [Read more...]
Kitchen Design: The 2016 Top Cabinet Choice
White kitchen cabinets: Classic. Timeless. Versatile. It is easy to see why homeowners are drawn to this enduring favorite. Houzz together with Kitchen & Bath Design News recently published a study showing that white cabinets are chosen 49% of the time. Almost half of us are doing white kitchens! Here in Chicagoland there are a number of factors my clients mention that influence this decision: v We are doing a huge amount of wood floors, often in mid and dark tones. To avoid the whole issue of matching the wood stain of the cabinets to the color of the flooring, we choose … [Read more...]
Kitchen Design: Going Gray
That phrase makes me think of my hairdresser, but I'm talking about gray being used in design. More and more clients are "going gray" in their kitchen spaces. It offers a versatile, refreshing change from the stand-by neutral cabinetry choices. In an article on Houzz, Jennifer Ott writes "Gray is continuing its run as a popular neutral hue in homes. It's still a bit of an unconventional choice as the predominant color in a kitchen, but that is quickly changing, as evidenced by the increasing number of gorgeous gray kitchens appearing on Houzz." And there are so many choices! Gray is … [Read more...]


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[…] Vendetta is great. It's all about a master thief named Tasana. I always play a thief in RPGs and D&D so this was just my sort… Read more "Scarlett Jasper on VENDETTA (via Goodreads)"
Jule Mcalpin on VENDETTA (via Goodreads)
The book starts out strong and doesn't lose strength. The story is both humorous and adventurous. Tasana, the master thief of this story, is a great female… Read more "Jule Mcalpin on VENDETTA (via Goodreads)"


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VW axes Routan van, mulls 7-passenger SUV replacement
- Sales not much more than 10%25 of what VW wanted
- Routan was Chrysler van with VW badges%2C trim
- SUV based on CrossBlue concept vehicle considered as replacement
Volkswagen says it has discontinued its Routan minivan -- a Chrysler with slight changes -- and is considering a seven-passenger SUV based on the CrossBlue concept vehicle as a replacement.
VW hasn't officially green-lighted the SUV replacement, so there's no word on when it might go into production. The concept model that made the rounds of auto shows was an exotic diesel-electric hybrid with three rows or two seats each.
VW says don't read anything into that. Routan's SUV replacement, if there is one, might not even offer a hybrid version, let alone a sophisticated -- costly -- diesel-electric model.
VW also never officially declared the Routan dead, until VW's U.S. CEO Jonathan Browning mentioned in a TV interview Monday that it was a discontinued model.
There is a 2014-model Routan, but VW says it's for the company's use only. You can't buy one from a VW dealer.
Routan went on sale in September 2008. In the five years it's been on the market VW has sold 57,683, says Autodata. That's an average of about 11,500 a year. Chrysler's Dodge Caravan, nearly identical to Routan, racks up about 110,000 sales a year.
VW had hoped to sell around 45,000 a year, but couldn't foresee the wrenching U.S. recession that wrecked sales of most cars and trucks in 2008-2009.
VW's intent was to avoid the heavy expense of developing its own family van. Routan was nearly identical to the Chrysler Town & Country and Dodge Caravan, save for some trim. The VW wasn't available with Chrysler's Stow 'n' Go second row seating, which allows the middle row to fold into big storage tubs under the floor.
In one way, that was an advantage: The Routan seats didn't have to skimp on seat-cushion padding in order to fit down into the tubs, the was the Chrysler Group models did. Thus, the VW van's second row was more comfortable than the second row in a Chrysler or Dodge van that had the optional Stow 'n' Go.
VW sold its last Eurovan in 2004, so went nearly five years with no family van.


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PARIS — Democratic presidential candidate Barack Obama will visit the West Bank next week as part of a swing through the Middle East, a Palestinian official said Monday, giving an important diplomatic boost to the Palestinians at a sensitive time in peace talks.
Other political news of note
Animated Boehner: 'There's nothing complex about the Keystone Pipeline!'
House Speaker John Boehner became animated Tuesday over the proposed Keystone Pipeline, castigating the Obama administration for not having approved the project yet.
- Budget deficits shrinking but set to grow after 2015
- Senate readies another volley on unemployment aid
- Obama faces Syria standstill
- Fluke files to run in California
- Animated Boehner: 'There's nothing complex about the Keystone Pipeline!'
The Palestinians expressed satisfaction over the planned meeting with the presumed Democratic nominee, which comes months after Obama's likely Republican opponent, John McCain, passed on meeting with the Palestinians during a brief visit to Israel.
Obama is scheduled to meet Palestinian President Mahmoud Abbas during his July 23 stop in Ramallah, said Palestinian negotiator Saeb Erekat, who was in Paris for a Mediterranean summit.
"We welcome this meeting," Erekat said. If Obama is elected, he added, "we hope he will stay the course between Israel and the Palestinians in reaching peace and a two-state solution."
During the same visit, Obama is expected to meet with Israeli Prime Minister Ehud Olmert and other Israeli officials. The Obama campaign declined to comment.
The visit will be closely watched. The U.S. is the key broker in Israeli-Palestinian peace efforts, and officials on both sides are trying to get a feel on whether Obama will change U.S. policy in the region.
President Bush is trying to broker a peace agreement before he leaves office.
In Paris on Sunday, Olmert said the sides are closer than ever to achieving peace, but it is uncertain whether they can meet Bush's target date for at least the outline of a final deal. Israel and the Palestinians remain at odds over key issues, such as the fate of Jerusalem, and a burgeoning corruption scandal has threatened to drive Olmert from office.
Video: Political satire or tasteless cartoon? Palestinians have privately complained that they suspect Bush is biased toward Israel, and expressed hope the next U.S. leader will be more sympathetic to their cause. While they have been careful not to take sides, officials were disappointed when McCain did not meet with them during his trip to Israel last March.
McCain has long been a strong supporter of Israel in the Senate, and it appears unlikely he will radically change Bush's policies. During his visit, McCain said he would "personally be engaged" in peace talks if he's elected and make the matter his "highest priority."
Obama's positions are far less clear.
In a recent speech to the American Israel Public Affairs Committee, he offered such ardent support for Israel that he had to backtrack just a few days later. Obama, working to woo Jewish voters, told the lobbying group that he supported Israel retaining control of an "undivided" Jerusalem. The comment so infuriated many Arab leaders that he was forced to issue a clarification that he didn't oppose Israeli-Palestinian negotiations over the future of the city.
Obama also has raised concerns among Israel's supporters because of his willingness to speak to Iran, while some have expressed concern about his Muslim roots. Obama's father and stepfather were Muslim and he spent part of his childhood in Indonesia, the world's largest Muslim country. But he is a Christian.
Few details of Obama's overseas travel schedule have been released. Obama's campaign has said he will travel to Iraq, Afghanistan, Jordan, Israel, Germany, France and Britain.
Copyright 2008 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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Laravel: Middleware Unit Test
Assalamualaikum / Hi, If you are working on a package, have a middleware and you want to write a unit test for it. Assuming you have the following middleware: So how you going to test it? The following gist, explained the setup. With this approach, we test just the middleware it self. Not related to… Read More »


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Jane Svoboda, whose anti-gay rant at a Lincoln, NE, City Council meeting went viral last week, isn't the crazy conservative she's been made out to be in the media, but a schizophrenic who lives at an assisted-living facility, says her family.
Svoboda is listed as a protected person, according to court documents, and her brother, Patrick Svoboda, is her conservator because she is incompetent. He said their family has tried to get her help multiple times, but there's little they can do unless she becomes a danger to herself or others.
He said he's disappointed that the video was so widely shared when people didn't know his sister's back story.
"To me, it shows how little society really cares about people with mental health issues," Patrick Svoboda said. "She does have a very tender heart... but anything she says is certifiably schizophrenic ... she's not some crazy conservative."
Nonetheless, Jane Svoboda is a registered lobbyist at the Capitol, and she usually speaks twice a month during the council's open mic sessions. She also frequents the University of Nebraska-Lincoln campus, where she hands out fliers and is known as the "Crazy Blue Protesting Lady."


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Have you ever carried burdens so heavy that some days it was all you could do to just keep putting one foot in front of the other? I have. These last few months I have carried some of the heaviest burdens ever. There have been some very dark days for me as of late.
In the midst of this, I met a Christian at Gold's gym who has been faithful in speaking God's truth to me. He does not spout platitudes, general wishes of well being, or the pop psychology of self help. He speaks of deeper things, of spiritual things. He speaks of the forces of darkness that conspire against us in truly terrible ways, of the power of the Holy Spirit to overcome, of the urgent importance of not losing sight of God or his mission for us in those times where our pain (or the pain of those we love) make Him seem so very distant. I cannot tell you how much his words have meant to me, or of how deeply I have been encouraged by them when I have sometimes wondered where I was going to find the strength to go on.
The Psalm for today tells the importance of speaking God's truth. We put a great deal of emphasis on our deeds as followers of Jesus. But our words are just as important. We need to put our faith in action. But we also need to put it in our words as well. People need to hear that God loves them, is with them, and will act on their behalf today as He has in our lives in the past. At least, I need to hear these words. I expect you do to.
May God grant us the faith, the love, the courage, to join the Psalmist in speaking these words to one another, to our kids, and to the world around us. Amen.


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CartManager is a robust reseller based online shopping cart service. We have been providing secure shopping cart services since 1998 and were one of the first shopping carts on the web.
The software used to build and manage an online store is critical to the overall success of an e-commerce venture. To be a successful e-commerce website it is necessary to provide customers with easy navigation, modern shopping cart features, a simple secure checkout process, and clear confirmation that their order has been received. CartManager will help increase conversion rates and drive secure sales volume.
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Argentina vs. Paraguay Match 2015 Copa America Preview, Predictions, Live Score
Argentina vs. Paraguay Match 2015 Copa America Preview, Predictions, Live Score
Argentina vs. Paraguay final score was : 2-2 in league match of copa america 2015. Argentina have been made by numerous individuals pre-tournament top picks to lift the current year's Copa America 2015 cup title and they will hope to get off on an in number balance in their semi final match against Paraguay, who were runner ups of this competition in 2011 copa cup.
Argentina vs. Paraguay Copa America 2015 News
With Lionel Messi on a high subsequent to completing the season with an exceptional treble at Barcelona and Sergio Agüero winning the Premier League Golden Boot, trusts are high notwithstanding Argentina not having won the opposition since the mid 1990s.
What's more, while La Albiceleste's principle quality is unmistakably in the power of their assault, in Nicolas Otamendi they have a standout amongst the most sought after safeguards in world football after a great season in La Liga for Valencia.
Their adversaries have a standout amongst the most experienced squads in the opposition, with three players having gathered more than a century of global tops. Between them, Justo Villar, Roque Santa Cruz and Paulo da Silva have a joined aggregate of 331 appearances for their country.
Both directors have their whole squads to pick from at this phase of the opposition, with Argentina administrator Gerardo Martino liable to stay with the same side that beat Bolivia 5-0 in a pre-tournament benevolent – with the increases of Messi and Javier Mascherano, who were caught up with winning the Champions League at the time.
Then, previous Blackburn Rovers and Manchester City target man Santa Cruz is his country's record-breaking most astounding scorer, and is liable to keep driving the assault at the time of just about 34. This gathering stage conflict at the Estadio La Portada will be the 104th meeting between the two sides, and it is a tie in which Argentina obviously appreciate a far prevalent record.
The World Cup finalists have won 58 times against Paraguay, who have only 15 triumphs in this installation to their name; it would be a noteworthy stun to see this number increment to 16, however it was additionally a noteworthy stun to see Paraguay in the Copa América last in 2011. Will Messi surpass Maradona that we have wait and watch ?
Likewise with the dominant part of Argentina's amusements, a significant part of the pre-tournament exhibit has encompassed Messi. While it is most likely reasonable to say that he has never caught hearts in his country to the same degree he has overseen in Catalonia, this competition gives the ideal opportunity to the 27-year-old to set up himself as one of Argentina's most loved children.
He fell at the last obstacle in Brazil a year ago, and, while that may well have been Messi's most obvious opportunity with regards to lifting the World Cup, the Copa America gives him the opportunity to better Diego Maradona, who never won the opposition amid his time with the national side.
Argentina vs. Paraguay Preview
Argentina have been made the top choices for a reason and ought to qualify from Group B no sweat. Uruguay are likely their just genuine danger in the gathering with Jamaica finishing the gathering line-up, and they will be raring to pass when they take to the pitch against a Paraguay side which has passed its crest following the last competition. An agreeable three- or potentially even four-objective triumph is sensible in what ought to be a genuinely uneven undertaking.
Argentina vs. Paraguay Line Ups – Squad
Argentina: Romero, Roncaglia, Otamendi, Garay, Rojo, Banega, Mascherano, Pastore, Di María, Messi, Agüero.
Paraguay: Villar, M Caceres, Balbuena, Da Silva, Samudio, Valdez, Benitez, Ortiz, V Caceres, Ortigoza, Santa Cruz.
Argentina vs. Paraguay Match Timings
June 30 – Tuesday. For India viewers match will start at 6:00 am (July 1st 2015).
Predicted score line : Argentina vs. Paraguay -: 3-2.
You can follow Giztimes on Facebook, twitter and Google Plus for more related stuff on Copa America 2015! 🙂
June 13, 2015 at 7:51 pm
Argentina vs Paraguay
Live Streaming Video Football : South America – Copa America
Saturday (13 June) 23:30 (GMT +2) 5


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Having sold over 500,000 copies of her books, she has solidified her position as one of the country's favourite storytellers.
Fleur draws inspiration from having lived and worked for much of her life on a farm – including early life on her parent's property in regional SA, and more recently on her 8000 acre property in regional WA.
Fleur's much-loved Detective Dave Burrows has his first rural fiction feature novel with Fool's Gold being released in April of 2018; and her twelfth novel, Where The River Runs, recently been released. Dave Burrows returns in Without a Doubt in April 2019.
Noisy Nights, the first of two children's books was published by New Frontier Publishers in August 2016 and the second, What does a horse Say? came out in August 2018.
She lives in Esperance, WA with her two children, Rochelle and Hayden, a Jack Russell terrier, Rocket and an energetic kelpie, Jack.
Fleur's much anticipated latest novel is now available to pre order
Have Questions?
Are you curious where I get my inspiration from or how did I get started as a writer?
Check out my FAQ page for answers.


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I was pulling down my pants to take it up the you know what. If your son says i want to build a stroked motor for my jeep Run. Run, run away and don't look back it's a horrible project.
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The INSIDER Summary:
- Disney's fan celebration D23 Expo kicked off Friday at the Anaheim Convention Center in California.
- The Marvel booth shows off our first look at villain Thanos in the next "Avengers" movie.
- Unlike previous times we've seen Thanos, the villain isn't wearing his helmet.
- Marvel unveiled four more characters who will work with Thanos in "Infinity War" on Saturday — Corvus Glaive, Proxima Midnight, Ebony Maw, and Cull Obsidian.
The next "Avengers" movie is in theaters next May, and we got a good glimpse of the villain at Disney's D23 Expo Friday at the Anaheim Convention Center.
The Marvel booth on the showroom floor has the real costumes used in "Black Panther" and "Thor: Ragnarok" on display, but there's also a statue showing off Thanos, the Marvel villain who was first teased in 2012's "The Avengers."
We've seen a bit more of Thanos, the father of Gamora and Nebula, in "Guardians of the Galaxy," but he'll finally take center stage in "Infinity War." Played by James Brolin, Thanos is expected to round up the Infinity stones, the powerful gemstones which have been teased throughout the Marvel movies for his own sinister plot.
While we've seen Thanos with his helmet on — and even with a gauntlet full of Infinity Stones — this is the first we've really seen of him off his throne.
Take a look at the statue on display:
Here's how his mighty frame will look from behind:
Over the weekend, Josh Brolin held up a poster featuring his character that was given out to fans.
It's wasn't just Thanos in the Marvel booth. Saturday, Marvel unveiled a look at several other characters who will join forces with Thanos in "Infinity War." These are the children of Thanos. The characters below are Corvus Glaive, Proxima Midnight, Ebony Maw, and Cull Obsidian in that order.
They'll all appear in "Avengers: Infinity War" when it arrives in theaters May 4, 2018.


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Take the pan out of the freezer and spread the protein powder mixture on top of the first nutty layer.
Use the same wax paper sandwich technique to spread it evenly. Put it back in the freezer.
Third Layer
Coarsely chop the rest of the almonds and walnuts in a food processor.
Combine with the last tablespoons of maple syrup and peanut butter and 1?2 ounce almond milk. Remove the pan from the freezer and do your spreading thing one last time.
Top Layer
Press the pumpkin seeds into the top layer of the bars. Sprinkle with some coarse salt. Cut the bars into six even parts and separate them in the pan. Freeze for another 30 minutes or so.
Microwave the chocolate and the oil in a bowl for 30 seconds. Remove. Stir. Microwave for another 30 seconds. Remove. Stir until smooth. Use a spoon to flick some chocolate over the top of the individual bars. Freeze until you're ready to eat them.
Makes 6 BarsMore: 5 Ways Chocolate Boosts Your Workouts
Perfect your nutrition to boost your performance. Sign up for a race near you.
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21-year-old Joshua James Driskell took a cab to the McDonald's next door to the Key Bank in October last year. Driskell went into the bank and allegedly handed the teller a note demanding $5,000 without saying a word. (Kitsap Sun)
According to Huffington Post Driskell was arrested for robbing the same bank and teller in September of 2010 and just completed his prison sentence a month before he did "The Job".
"When police investigated the latest robbery at that branch, they didn't have to look hard to find their suspect. Police say surveillance cameras caught clear photos of Driskell, as well as his getaway car. He was arrested at his apartment only three hours after the crime, the car was parked in the apartment complex." – CBS SEATTLE
To put the icing on the cake when police spoke to Driskell, he told them out of the $2000 get got from the job he spent most on marijuana. What?!? You just said "F" it after you got caught didn't you Driskell lol.
You Big Dummy!!


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US Formally Recognize Jerusalem As Israel's Capital, Orders US Embassy Moved - Video
US President, Donald Trump on Wednesday formally recognized Jerusalem as the capital of Israel, reversing nearly seven decades of American foreign policy and setting in motion a plan to move the United States Embassy from Tel Aviv to the fiercely contested Holy City.
According to Trump:
"Today we finally acknowledge the obvious: that Jerusalem is Israel's capital," Mr. Trump said from the Diplomatic Reception Room of the White House. "This is nothing more or less than a recognition of reality. It is also the right thing to do. It's something that has to be done."
The president cast his decision as a break with decades of failed policy on Jerusalem, the United States, along with virtually every other nation in the world, has declined to recognize as the capital since Israel's founding in 1948. That policy, he said, brought us "no closer to a lasting peace agreement between Israel and the Palestinians."
"It would be folly to assume that repeating the exact same formula would now produce a different or better result," Mr. Trump declared. Recognizing Jerusalem, he added, was "a long overdue step to advance the peace process."
Mr. Trump's remarks were the most closely scrutinized of his presidency on the Middle, where he has vowed to broker the "ultimate deal" between Israelis and Palestinians but has yet to find a breakthrough to end the conflict. He said he remained committed to brokering an agreement "that is a great deal for the Israelis and a great deal for the Palestinians."
The president said the decision to recognize Jerusalem should not be construed as the United States taking a position on whether, or how, the city might ultimately be shared. But he offered little solace to the Palestinians, making no mention of their long-held hopes for East Jerusalem to be the capital of a Palestinian state.
Instead, Mr. Trump emphasized the domestic political dimension of the decision. He noted that he had promised to move the embassy during the 2016 presidential campaign, and added, "While previous presidents have made this a major campaign promise, they failed to deliver. Today, I am delivering."
Full Donald Trump's speech ....see footage below....


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Your furnace is a huge investment, and can also come with unexpected costs if you don't take care of it properly. Here are some signs that it might be time for you to stop paying for those repairs every month and invest in a replacement. Furnace Life Span: Did you know the average life span… Read more »
Monthly Archives: December 2014
Preparing Your Home for Winter
Here in Lorton, VA, it no longer feels like fall! It isn't officially winter until December 21st, but the weather has definitely said otherwise! Now that the chilly nights have turned into frigid nights, it's time to get your home really prepared for the nights where it's just too cold to step outside! Here at… Read more »
Meet Bob Stachoviak, Parts & Warehouse Manager
Bob has been with M&M Mechanical for over 20 years. In addition to his role as Parts & Warehouse Manager, his duties also include procuring permits and assisting installation and service technicians with jobs that require additional manpower. Bob is an extremely hardworking, dedicated employee with the highest integrity. M&M Mechanical wishes to thank Bob… Read more »


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The Parish Pub & Music Venue has been putting on live music in Huddersfield for over 10 years.
In this time we have had over 1000 gigs from 1500 bands, won national awards, had over 3285 amazing nights and sold 10s of thousands of burgers.
At The Parish pub in Huddersfield, we aim to give our patrons the very best experience possible.
We pride ourselves on getting the best bands and artists to play at our venue, as music really does matter. If you are interested in playing at The Parish or looking for a great music venues in West Yorkshire, please check out this or contact Mikey our Events Manager for more information.
As well as offering the best live music, The Parish Huddersfield serves delicious home cooked food at resonable prices, and offers a wide range of drinks - with something to suit every taste - including ale, beer, wine, spirits, shots and cocktails!
As the most versatile pub in Huddersfield, The Parish offers something different. We have unique gigs and events going on each week, such as our infamous Monday Quiz night, with recent prizes including an IPAD MINI and XBOX.
A trip to Huddersfield wouldn't be complete without a trip to The Parish. Simples.
Join In On The Fun...
Check out some of our upcoming gigs, and grab yourselves some tickets... you know you want to.View Upcoming Gigs


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I've heard people say you should retire to something, not from something. And I've heard lots of people in the financial independence community talk about what they plan to do once they've retired from their "real" job.
I'm no different — I have so many aspirations, I could fill at least 10 lifetimes pursuing them all. I've vaguely alluded to these aspirations here, with the tantalizing promise that I'd talk about them more "in a later post." (Need a refresher? Take a trip down memory lane to my first ever post.)
Well, friends, THE WAIT IS OVER.
Most pressingly, I'd like to write fiction and start a business. I'd also like to grow this blog, be present for my kids' childhoods, and get back to my pre-pregnancy running and biking habits. And take long trips with my family. And, and, and!
I feel that each of these aspirations could be a full-time job in itself, there's so much I'd love to do with them (and so much work I need to do on them to get where I'm going)… in fact, the only thing I don't want to be spending full time on is… my actual job. Womp womp!
But I'm not quite ready to be without a reliable income yet. For one, we aren't financially independent. And I don't want to put pressure on my other endeavors to be lucrative right out of the gates… I mean of course if I start a business I hope it becomes profitable, and if I write a book I hope it's a smash hit with a wide and adoring fan base… but that can't be the primary motivator. First and foremost, I want to write books I love, and build a business with an awesome product that I'm proud of. If they take a while to catch on (or I take a while to perfect them), I want to give them the opportunity to get there, which requires that I have some financial security already so I'm not desperate for the dollars to start coming in from my creative endeavors!
Sooooo for now, the job stays.
BUT! I've been trying to get started on my business and on writing on the side.
Re: the business: One of my colleagues (who I barely knew at the time) shared her "million dollar idea" with my husband a while back and I immediately recognized it for pure gold (no, I'm not ready to share what it is yet… it's still just a baby idea, it needs time to evolve!). I started looking into it and daydreaming… and daydreaming… and looking into it… And becoming friendly with said coworker (unrelated to the million dollar idea–she happens to be lovely)… and daydreaming…
A few months ago, the coworker said, "let's get out of this law firm life and start a business. What kind of business should we start?" Sooooo… I revealed to her that I knew of her million dollar idea and thought it was, in fact, a million dollar idea. And for the past few weeks, we've been excitedly looking into it together. We have a shared Google Docs folder of inspiration and articles and industry contacts, and we've started reaching out to people we know that might help us. I started watching some videos on how to write a business plan. It feels like a pipe dream. But it feels good to dream! And maybe it will turn into something…
As for writing, I was on the war path to set a writing routine while I was on maternity leave. (As every new parent knows, having a newborn is a GREAT time to get stuff done…. errrrrr…..) I've been listening to the Story Grid Podcast for a few years now and am all amped up to learn the craft of writing fiction. I read Stephen King's "On Writing" and Steven Pressfield's "The War of Art." And for a few days here and there I'd force myself to sit down at that damn desk and WRITE. ANYTHING. I've got the beginnings of 2 novels, and the beginnings of 2 short stories, and it's now been months since I've worked on any of them….
I'm feeling excited about everything, but frustrated that there simply isn't enough time to do it all. I know that to succeed at anything I need to pick one thing and really focus on it, and right now it feels like I'm trying to do it all and falling short at everything… but… that's where I am. And now you know, so you're here with me too. Welcome!


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After a roller coaster ride that lasted almost three years, the Indian Parliament passed the Real Estate Regulatory Act, 2016 (RERA) in March this year. The passing of RERA brought cheer to millions of Indians, especially those who were at the mercy of Builders/Developers for their apartments/flats. People across India have high expectations from RERA and its effective implementation. They have come to view this regulation as a major milestone that will grant them relief from the raft of issues that they have been facing while interacting with various builders and developers.>>
22 Nov 2016
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Our concerns for the environment rely on our guest participation as well, little details such as ensuring rubbish is disposed of, respecting the landscape and conserving energy where possible not only effects our company, but also our community.
Community involvement is something very close to our hearts, especially for those in the green team. Below is a list of our initiatives from charity events to our running club many of the initiatives are focused on the local community.
A Guide to Ethical Travel
Ethical Travel
Green Calendars
Green calendars are produced highlighting Green opportunities and events to take part in throughout the year.
Running Club
We have set up the summer "Victoria Royal Runners" Running Club for members of public in London to run together. Find us on twitter.
Sponsored Runs
As well as our running club, we also try to run regular sponsored runs and walks to raise money for various local charities.
Considerate Hotels
We are a Member of Considerate Hoteliers.
Green Carnation Week
This is an annual event, which we take part in and run various events and initiatives to raise awareness of being green, for example many of our staff members wear large green carnations for the week.
Vegan Afternoon Tea
If you wish to enjoy afternoon tea, there is a completely vegan option available.
Jogging Station
We have a joggers station setup in the lobby for early morning runners which has towels water and local jogging map.
Easter Initiative
We take part in yearly Easter Egg donation to local Children's Charity.
Earth Hour
Annually we take part in the Yearly Earth Hour participation, which is a worldwide movement, encouraging businesses and people to turn off non-essential electric for one hour.
Kidscape Charity
We are a key supporter of the Kidscape Charity, raising money for children that have been bullied or harmed and ensuring they have a safe and secure life.
Browse images and video


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Gay culture is biased against quiet and reserved guys. Often, they're considered boring, emotionally unavailable or weird, but in today's digital world the role of "introvert" is more popular than ever. And we all want to be popular.
I'm an introvert pretending to be an extrovert most of the time. No one wants people to have a wrong impression of themselves, which explains why when I first moved to Hollywood there was pressure to shape an appropriate image for myself.
In the gay community we seem to follow the most dominant man in the room, despite there being zero correlation between good ideas and good schmoozing. Nevertheless, a boy with the biggest personality wins every time, which is why introverts feel like they couldn't stand a chance. But things are different.
Is it sexy to be a gay introvert? Many gay guys today act like introversion is some sort of political or fashion statement–as if their silence boosts mystery points. Frankly, I've seen pickles with better personalities than some.
To be fair, film and TV often exaggerate introverts by making them cliché: a writer, an artist, or tech guy with a heart of gold who wears black and writes in a journal on the subway; the sensitive soul an audience roots for. For young guys watching, it's easy to view it not as a true reflection of themselves, but a prototypical image whose accolades they want as trophy points.
The world is built on impulse. While extroverts often fail to think before they act, an introvert gives himself time to rationalize. We need both aspects to survive successfully. With a growing existence of introverts, we might throw off the balance of life as we know it–which might not be a bad thing.
Ten years ago, bars were full of finger-snapping strangers not giving a fuck about volume, space or filters, but today everyone is on their phones or observant in a corner somewhere, attempting to be introspective. What's next for the cosmos?
Before we go any further, let's discuss what it means to be introverted. After all, according to research, introverts are one-third to half of the population.
Being introverted does not mean you're depressed, antisocial or hate the world for any reason. We receive our energy from inside, like a battery, while extroverts often get their energy from outer vibes. Introverts, by their very nature, are natural thinkers, which means they create a lot. Extroverts are impulsive, which means they build. Some of us are ambiverts (a balance of both), but typically we're more one than the other.
Introverts have to refuel our batteries more often than everyone else because we need to, not because we hate the world or because we're sad. In fact, most introverted people I know are happier than extroverts, who tend to trick the world into thinking their happy when in reality they're going through hell.
Introverts express joy through action and personalization, whereas extroverts typically feel pressure to show it extravagantly and publically. This is why Facebook has confused the living sh*t out of everyone.
To an introvert, social media seemed to be a gift from God. We could be social without being bombarded with noise or Debbie downers. We type an exclamation point in our status, and boom! The world might think we're extroverted.
One of the biggest problems I've found is that because Facebook has turned into a portfolio to display our personality. We see it as an opportunity to be the dominant personality online, rather than in the room–extroverts and introverts are competing for the title, but it's hardly ever genuine. The funniest people I know on social media are also the shyest.
In the dating scene, mystery is alluring. It pulls us in by making us think we're hiding something, but introverts only open up when we trust you—if we don't trust you, it's professional. Is this a sexy quality? Apparently so.
Looking around today, people are embracing introversion, which I think is great. But frankly, we need extroverts in the world too! Without which we might fail to act on our thoughts, and instead choose to live in an imaginative world. Believe me, wearing black and carrying a journal as a fashion trend does not make you an introvert. It makes you a poser.
I'm grateful that we introverts are "in" now, but the sexiest quality any man will have is authenticity. If you have to pretend to be anything, you're not as hot as you think.
Think long and hard about what makes you tick, what gives you peace, what makes you feel alive–roll with that. Till then, I'll be doing something introspective in the corner.


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On Air Now
Early Breakfast with James Stewart 4am - 6:30am
Police are warning shoppers that a couple of men are going around supermarkets in Hampshire distracting people and stealing their bank cards.
While shopping in Winchester and Totton four people have reported being approached by a man at the checkout who picked up money from the floor, on most occasions it was a £20 note, and then attempted to give it to the victim, claiming that they have dropped it.
On the four occasions, two at Tesco, Winnall, one at Sainsburys, Winchester and one at Morrisons, Totton, the victims declined the cash but the offender has managed to distract the victim to the point of being able to take their bank card. Large amounts of cash have then been withdrawn from their accounts.
Officers have descriptions of the men they would like to speak to:
The man at Tesco, Winnall on November 18 is described as:
- Of a continental origin, possibly Spanish or Italian
- Aged in his mid 40s
- Around 5ft 8ins
- Dark hair which was slightly balding
- Wearing an open neck white shirt, black trousers and a black top
The man at Sainsburys, Winchester on November 18 is described as:
- White
- Around 5ft 5ins
- Aged in his 50s
- Wearing a dark knee length trench coat
- He possibly spoke with a foreign accent
The man at Tesco, Winnal on November 16 is described as:
- White
- Around 5ft 1ins
- White / grey hair
- Wearing a long Khaki coloured coat which was calf or ankle length, grey trousers, and a pale blue head scarf
The man at Morrisons, Totton on November 16 is described as:
- White
- Stocky build
- Wearing dark blue clothing
- Cropped hair
- He spoke with an Eastern European accent
PC Carolyn Bulpit, said: "It appears that on each occasion the offender has some how managed to obtain the PIN of the stolen cards, possibly by watching the victims at the checkouts before distracting them and taking their cards.
"I would advise shoppers to always cover their PIN completely when entering it and to place their bank cards in a secure location, preferably inside a wallet or purse which is then zipped or fastened and placed inside another bag or zipped pocket.
"If anyone is approached by someone using a similar technique do not engage in conversation with them or allow them to get close to your personal belongings. Please ensure you stay vigilant and report any suspicious behaviour to the police immediately."
Anyone with any information should contact PC Bulpit at North Walls police station on 101 or call Crimestoppers, the charity, anonymously on 0800 555 111.


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The spirit of the Law, as opposed to the letter of the Law, is what matters to God. It's about heart, will, spirit, nature, or character, which is where the legalistic Pharisees went afoul.
Not all people who keep the Law are righteous. And people who don't keep the Law are not righteous. But all righteous people keep the Law—not flawlessly, but wholeheartedly in the Spirit of love and joy.
Today, the debate rages on over how the Law, grace, atonement, and faith relate. It's easy to get confused by apparent contradictions in Paul's letters, or seeming conflict between Paul and Jesus. The incorrect premise is that through the cross, Jesus abolished the Law. But what he actually abolished, for the joy set before him, was spiritual Death.
God's Law is Good
This act of grace on God's part allows us to safely re-learn how to live in the goodness of His ways. But, according to Paul, the sinful mind opposes the Spirit and therefore does not, and cannot, correctly submit to God's Law.
Of course, the Law by itself won't make you a good person any more than traffic rules will make you a good driver because no one, including God, can legislate morality. No law has transformative power. But spirit and intent does, including the spirit of God's Law.
So it isn't some evil thing to avoid. After all, it's as much God's Word as anything else is. Cheerful, willing practice brings increasing competence and blessedness. "He has made us competent as ministers of a new covenant—not of the letter but of the Spirit; for the letter kills, but the Spirit gives life." (2Cor. 3:6)
Grace and faith don't kill obedience, but rather, bring it to life, although God expects it to be child-like and clumsy at first. That's okay, and in fact, necessary; and that's good news!
Preliminary Thoughts Toward the Mind of the Spirit
As I wrote in another post, and to shed light on the confusion, it's important to first distinguish between secondary laws like clean vs. unclean food, tithing, circumcision, etc., and the Law, the Ten Commandments. Jesus boiled the Law down to two commands: Love God, and love your neighbor as yourself.
Paul boiled it down to one: "The entire law is summed up in a single command: 'Love your neighbor as yourself.'" (Gal. 5:14) And James put it this way: "If you really keep the royal law found in Scripture, 'Love your neighbor as yourself,' you are doing right." (Jas. 2:8) All three men are quoting Leviticus 19:18, the Law of the Spirit and spirit of the Law.
We should also assume Jesus to be the prime Expert on anything and everything. No Pharisee, priest, prophet, apostle, scholar, or institution overrides him; and he never cancelled the Law. So really, no amount of worship, confession, prayer, "belief," bible study, speaking in tongues, or witnessing can honor the Lord if his Law is ignored because, according to him, "If you want life, obey the commandments." (Mat. 19:17) Again, we're looking at spirit, intent, and desire as opposed to a grim, outward image of compliance.
Enduring Wisdom
Don't think that I have come to abolish the Law or the Prophets; I have not come to abolish them but to fulfill them. I tell you the truth, until heaven and earth disappear, not the smallest letter, not the least stroke of a pen, will by any means disappear from the Law until everything is accomplished." (Mat. 5:17-18)
"It's easier for heaven and earth to disappear than for the least stroke of a pen to drop out of the Law." (Luk. 16:17)
With his fine intellect and wit, Jesus often addressed serious issues with a touch of sarcastic humor, aimed mostly at bombastic Pharisees who imposed heavy life-style burdens. He knew that neither heaven nor Earth would be disappearing anytime soon; so these remarks showed just how serious he was about the true Law, yet simultaneously told misguided Pharisees to lighten up.
Heaven and Earth still haven't gone away and everything is not yet accomplished. Therefore, if we're to take Jesus seriously, we should understand that the Law remains in effect today. It's silly to call him Lord if we're going to disregard him, and even more ridiculous to pit the cross, the ultimate act of love, against the Law, the ultimate policy of love, both of which come from God who is love.
So when Jesus says to keep the commandments, he doesn't mean to go get circumcised and make a burnt offering, or be sure to stone your neighbors when they wrong you. He means to become a healthy person who happily thinks and carries out acts of love.
Tomorrow (rather than next week), with these preliminaries in mind, Part 2 will look at what Paul has to say in the book of Romans. You might be as pleasantly surprised as I was that there's less confusion than most of us have been taught.


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Rx drug information, pharmaceutical research, clinical trials, news, and more
For Intravenous Use Only
10 mg/10 mL (1mg/mL) ampule
TRISENOX is a sterile injectable solution of arsenic trioxide. The molecular formula of the drug substance in the solid state is As2O3, with a molecular weight of 197.8 g.
TRISENOX is available in 10 mL, single-use ampules containing 10 mg of arsenic trioxide. TRISENOX is formulated as a sterile, nonpyrogenic, clear solution of arsenic trioxide in water for injection using sodium hydroxide and dilute hydrochloric acid to adjust to pH 8. TRISENOX is preservative-free. Arsenic trioxide, the active ingredient, is present at a concentration of 1.0 mg/mL. Inactive ingredients and their respective approximate concentrations are sodium hydroxide (1.2 mg/mL) and hydrochloric acid, which is used to adjust the pH to 7.5 - 8.
The mechanism of action of TRISENOX is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells in vitro. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha.
The inorganic, lyophilized form of arsenic trioxide, when placed into solution, immediately forms the hydrolysis product arsenious acid (AsIII). AsIII is the pharmacologically active species of arsenic trioxide. Monomethylarsonic acid (MMAV), and dimethylarsinic acid (DMAV) are the main pentavalent metabolites formed during metabolism, in addition to arsenic acid (AsV) a product of AsIII oxidation. The pharmacokinetics of arsenical species ([AsIII], [AsV], [MMAV], [DMAV]) were determined in 6 APL patients following once daily doses of 0.15 mg/kg for 5 days per week. Over the total single dose range of 7 to 32 mg (administered as 0.15 mg/kg), systemic exposure (AUC) appears to be linear. Peak plasma concentrations of arsenious acid (AsIII), the primary active arsenical species were reached at the end of infusion (2 hours). Plasma concentration of AsIII declined in a biphasic manner with a mean elimination half-life of 10 to 14 hours and is characterized by an initial rapid distribution phase followed by a slower terminal elimination phase. The daily exposure to AsIII (mean AUC0-24) was 194 ng·hr/mL (n=5) on Day 1 of Cycle 1 and 332 ng·hr/mL (n=6) on Day 25 of Cycle 1, which represents an approximate 2-fold accumulation. The primary pentavalent metabolites, MMAV and DMAV, are slow to appear in plasma (approximately 10-24 hours after first administration of arsenic trioxide), but, due to their longer half-life, accumulate more upon multiple dosing than does AsIII. The mean estimated terminal elimination half-lives of the metabolites MMAV and DMAV are 32 hours and 72 hours, respectively. Approximate accumulation ranged from 1.4- to 8-fold following multiple dosing as compared to single dose administration. AsV is present in plasma only at relatively low levels.
The volume of distribution (Vss) for AsIII is large (mean 562 L, N=10) indicating that AsIII is widely distributed throughout body tissues. Vss is also dependent on body weight and increases as body weight increases.
Much of the AsIII is distributed to the tissues where it is methylated to the less cytotoxic metabolites, monomethylarsonic acid (MMAV) and dimethylarsinic acid (DMAV) by methyltransferases primarily in the liver. The metabolism of arsenic trioxide also involves oxidation of AsIII to AsV, which may occur in numerous tissues via enzymatic or nonenzymatic processes. AsV is present in plasma only at relatively low levels following administration of arsenic trioxide.
Approximately 15% of the administered TRISENOX dose is excreted in the urine as unchanged AsIII. The methylated metabolites of AsIII (MMAV, DMAV) are primarily excreted in the urine. The total clearance of AsIII is 49 L/h and the renal clearance is 9 L/h. Clearance is not dependent on body weight or dose administered over the range of 7-32 mg.
The effect of age, gender, or race on the pharmacokinetics of TRISENOX has not been studied.
Following IV administration of 0.15 mg/kg/day of arsenic trioxide in 10 APL patients (median age = 13.5 years, range 4-20 years), the daily exposure to AsIII (mean AUC0-24h) was 317 ng·hr/mL on Day 1 of Cycle 1 (see
PRECAUTIONS, Pediatric Use).
The effect of renal impairment on the pharmacokinetics of AsIII, AsV, and the pentavalent metabolites MMAV and DMAV was evaluated in 20 patients with advanced malignancies. Patients were classified as having normal renal function (creatinine clearance [CrCl] > 80 mL/min, n=6), mild renal impairment (CrCl 50-80 mL/min, n=5), moderate renal impairment (CrCl 30-49 mL/min, n=6), or severe renal impairment (CrCl < 30 mL/min, n=3). Following twice weekly administration of 0.15 mg/kg over a 2-hour infusion, the mean AUC0-
∞ for AsIII was comparable among the normal, mild and moderate renal impairment groups. However, in the severe renal impairment group, the mean AUC0-
∞ for AsIII was approximately 48% higher than that in the normal group.
Systemic exposure to MMAV and DMAV tended to be larger in patients with renal impairment; however, the clinical consequences of this increased exposure are not known. AsV plasma levels were generally below the limit of assay quantitation in patients with impaired renal function (see
PRECAUTIONS). The use of arsenic trioxide in patients on dialysis has not been studied.
The effect of pharmacokinetics of AsIII, AsV, and the pentavalent metabolites MMAV and DMAV was evaluated following administration of 0.25-0.50 mg/kg of arsenic trioxide in patients with hepatocellular carcinoma. Patients were classified as having normal hepatic function (n=4), mild hepatic impairment (Child-Pugh class A, n=12), moderate hepatic impairment (Child-Pugh class B, n=3), or severe hepatic impairment (Child-Pugh class C, n=1). No clear trend toward an increase in systemic exposure to AsIII, AsV, MMAV or DMAV was observed with decreasing level of hepatic function as assessed by dose-normalized (per mg dose) AUC in the mild and moderate hepatic impairment groups. However, the one patient with severe hepatic impairment had mean dose-normalized AUC0‑24 and Cmax values 40% and 70% higher, respectively, than those patients with normal hepatic function. The mean dose-normalized trough plasma levels for both MMAV and DMAV in this severely hepatically impaired patient were 2.2-fold and 4.7-fold higher, respectively, than those in the patients with normal hepatic function (see
No formal assessments of pharmacokinetic drug-drug interactions between TRISENOX and other drugs have been conducted. The methyltransferases responsible for metabolizing arsenic trioxide are not members of the cytochrome P450 family of isoenzymes.
In vitro incubation of arsenic trioxide with human liver microsomes showed no inhibitory activity on substrates of the major cytochrome P450 (CYP) enzymes such as 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4/5, and 4A9/11. The pharmacokinetics of drugs that are substrates for these CYP enzymes are not expected to be affected by concomitant treatment with arsenic trioxide (see
TRISENOX has been investigated in 40 relapsed or refractory APL patients, previously treated with an anthracycline and a retinoid regimen, in an open-label, single-arm, non-comparative study. Patients received 0.15 mg/kg/day intravenously over 1 to 2 hours until the bone marrow was cleared of leukemic cells or up to a maximum of 60 days. The CR (absence of visible leukemic cells in bone marrow and peripheral recovery of platelets and white blood cells with a confirmatory bone marrow ≥ 30 days later) rate in this population of previously treated patients was 28 of 40 (70%). Among the 22 patients who had relapsed less than one year after treatment with ATRA, there were 18 complete responders (82%). Of the 18 patients receiving TRISENOX ≥ one year from ATRA treatment, there were 10 complete responders (55%). The median time to bone marrow remission was 44 days and to onset of CR was 53 days. Three of 5 children, 5 years or older, achieved CR. No children less than 5 years old were treated.
Three to six weeks following bone marrow remission, 31 patients received consolidation therapy with TRISENOX, at the same dose, for 25 additional days over a period up to 5 weeks. In follow-up treatment, 18 patients received further arsenic trioxide as a maintenance course. Fifteen patients had bone marrow transplants. At last follow-up, 27 of 40 patients were alive with a median follow-up time of 484 days (range 280 to 755) and 23 of 40 patients remained in complete response with a median follow-up time of 483 days (range 280 to 755).
Cytogenetic conversion to no detection of the APL chromosome rearrangement was observed in 24 of 28 (86%) patients who met the response criteria defined above, in 5 of 5 (100%) patients who met some but not all of the response criteria, and 3 of 7 (43%) of patients who did not respond. Reverse Transcriptase – Polymerase Chain Reaction conversions to no detection of the APL gene rearrangement were demonstrated in 22 of 28 (79%) of patients who met the response criteria, in 3 of 5 (60%) of patients who met some but not all of the response criteria, and in 2 of 7 (29%) of patients who did not respond.
Responses were seen across all age groups tested, ranging from 6 to 72 years. The ability to achieve a CR was similar for both genders. There were insufficient patients of Black, Hispanic or Asian derivation to estimate relative response rates in these groups, but responses were seen in members of each group.
Another single center study in 12 patients with relapsed or refractory APL, where patients received TRISENOX (arsenic trioxide) injection doses generally similar to the recommended dose, had similar results with 9 of 12 (75%) patients attaining a CR.
All Rights reserved - Copyright DrugLib.com, 2006-2017


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In what may very well be the saddest last-ditch attempt to maintain relevancy in the history of American dining, Applebee's announced on Monday the "biggest investment in culinary excellence in the company's history," part of its efforts to "to take back America's neighborhoods."
As Americans become more educated about the fact that they don't have to eat lackluster, prefabricated food when dining out, Applebee's profits have fallen — sales at the chain eatery fell 3.7 percent in the first quarter of 2016, the Wall Street Journal reports. Don't get me wrong, Applebee's is still worth a boatload of cash — IHOP bought it for $2.1 billion in 2007 — but much like Big Beer saw its profits decline as Americans wised up to craft beer, Applebee's is having a harder and harder time defending its subpar offerings as diners become more entrenched in their cities' dining options.
Rather than sit back and wallow in an app sampler, Applebee's is fighting back — with steak. Yes, a restaurant notorious for serving the lowest-quality food they can legally still call "food" is going to focus on steak. "Applebee's Neighborhood Grill & Bar will unveil a nationwide transformation that includes new American-made, wood fired grills as the centerpiece of nearly 2,000 of its U.S. restaurants (40 in Dallas) and will introduce certified USDA Choice steaks as the marquee item of a revamped and streamlined menu," according to the press release. "... the new Hand-Cut Wood Fired platform is the first chapter in the reinvention of the Applebee's brand."
First of all, let's consider the fact that there are 40 Applebee's restaurants in Dallas. This city has one of the biggest and most active dining scenes in the country, and that scene includes 40 goddamned Applebee's. So what's about to happen to those 40 locations? SO MUCH, Applebee's says. New menu items will include "USDA Choice top sirloin steaks, bone-in pork chops, cedar-grilled salmon" and "new wood corrals stacked with split oak logs greeting guests at the entrance, accompanied by mouth-watering aroma of oak wood smoking."
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Applebee's rebranding strategy: stacks of wood and wood smells. Could this possibly fool anyone older than 8 years old?
The revamp will also include "upwards of 60,000 hours of training for employees, including meat cutter training," according to the release, and an "investment of more than $40 million by Applebee's franchisees." Right now, Applebee's franchise owners around the country are sweating bullets at the realization that they'll have to dump a boatload of cash into their enterprises.
In the press release announcing the "Hand-Cut, Wood-Fired Platform," Applebee's readily admits that things have changed in the U.S. since the chain launched in 1980. "... Shifting consumer tastes and public perceptions have challenged its business performance," the press release reads. "The moves being initiated today are the first in a series of actions meant to change the story."
A few stacks of wood are not going to change Applebee's story, one of subpar food that's reheated to order in an environment that makes any sentient human feel as if they're being slowly tortured in the presence of honey barbecue riblets. The only way to change that story would be to throw away their business model and realize that in 2016, Americans want more from their food. They want a sense of place, a feeling of community. Slapping a few wood-fired grills into 2,000 restaurants is just another way for Applebee's to blow smoke.


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Hard Maple Blanks
Bocote Hardwood Slabs – Product Highlight
What Is Quarter Sawn Wood?
Using Live Edge Slabs
Getting Started Turning Wooden Pen Blanks
Hardwood Milling Services
Rough lumber is rarely flat or straight. Milling your own can save you some money but it will take time, equipment and a strong back. It can be beneficial to look into what milling options your distributor can...
Tips for Buying Lumber from a Retail Lumber Store
Once you've decided to go beyond buying lumber at a home center, there's some major differences to be aware of when buying lumber at a lumberyard or retail lumber store.
How to Determine Board Footage
Understanding board footage is not as tough as you think. Use this simple guide to understand more about how to calculate board feet, as well as determining lumber thickness.


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AEL Mining Services, a South Africa-based supplier of commercial explosives, initiating systems and blasting services, recently reported the Rukodzi mine, part of Zimbabwe Platinum Mines' Ngezi Mining Division, converted its perimeter blasting practice from AEL's PE Barrel to polypipes, after using the former system in its bord (room) and pillar blasting operations since 2003.
PE Barrel is a water gel explosive packaged in special plastic tubes that can be clipped together for use in holes where a decoupled charge is needed. Applications include smooth blasting of perimeter holes in shaft sinking, development or tunneling.
"PE Barrel, a specialist blasting technique product manufactured at low volumes, is supplied at a premium compared to other standard explosives. Due to the drop in platinum prices in 2008 driven by the global commodity crisis, Ngezi Mining Division's quest for best practices in all its mining activities was accelerated," said Gift Zhou, Ngezi Mining Division's best practice manager.
Late in 2008, a team from AEL Mining Services initiated a project to find a more cost-effective alternative to PE Barrel, and subsequently recommended an innovative approach which was trialed during the mining of tunnels for the Gautrain Rapid Rail project in Johannesburg, South Africa. This innovation involved a trial with emulsion charged into polypipes as an alternative to PE Barrel.
"The results recorded were outstanding and encouraged full scale trials in Rukodzi mine, resulting in the total conversion to polypipes, which was concluded in June 2010," said Zhou.
Although the conversion resulted in a 3% increase in powder factor, the net effect of the conversion was a 3% saving in explosives cost per metric ton blasted.
AEL said its relationship with Zimplats Ngezi Mining Division dates back to 2001 when Ngezi issued an explosives tender to provide Prime, Load, Tie and Shoot (PLTS) blasting services for the open-pit mine. AEL was initially awarded a three year PLTS contract. Over the years following the initial contract, more 70,000 tons of emulsion has been used to blast ore and overburden totaling approximately 60 million bcm using a fleet of four AEL Mobile Manufacturing Units.
AEL's UBS technology in conjunction with Tunnelmaster shock tube system was accepted as the blasting system for Ngezi Mining Division's bord and pillar mining after extensive trials at the start of underground mining in 2003.
In another offshoot from AEL's involvement in the Gautrain project, the company said it recently completed the first phase of the Goldfields South Deep shaft sinking project using its QuickShot electronic detonator system to sink 110 m of the 9.4-m-diameter shaft. This followed a contract awarded to AEL by Murray and Roberts in April 2010.
"Having seen the outstanding results from the Gautrain Project blast, QuickShot electronic detonators were the natural choice to deepen the Goldfields' South Deep Gold mine, some 3,000 meters," said Mark Mocombe, vice president of Goldfields South Deep.
"AEL's QuickShot electronic detonator system, developed by our sister company, DetNet, debuted with the Gautrain project and achieved maximum advance rates, as well as adherence to environmental restrictions. Blasting was performed without incurring damage to sensitive structures on surface with Peak Particle Velocity levels well under the target maximum of 10 mm/s," said Carlos Goncalves, product manager, AEL Electronics.
With existing foundations at the South Deep shaft project very close to the perimeter blast ring—a 234-hole by 1.2-m deep round—care had to be taken to not inflict damage on the winder and compressors.
"Given that this was new to us and the crew members, we had no idea how complex the drill and blast design could be. AEL demonstrated leadership in underground blasting and we are satisfied with the work done so far. The shaft is starting to take shape nicely," said Morcombe.
The second phase of the project requires a further 143 m of sinking and has not yet been awarded.
Meanwhile, the Dutch company NX Burst Europe BV announced the introduction of NXbursT, which it claims is a safer alternative to traditional explosives used for specialized and secondary blasting applications in the mining and demolition sectors. The technology is based on a non-detonating chemical compound enclosed in a cartridge, which reacts quickly when ignited to produce high volumes of harmless gas, mainly consisting of nitrogen, carbon dioxide and steam.
When the cartridge is sealed in a drill hole, the gas generated by the ignition of the propellant enters into the micro-fractures created from the percussive drilling process and into the natural fractures and planes of the rock to produce a shearing often known as splitting. There are no expensive initiation systems required or special tools needed. It is said to be fast, simple and, most importantly safe.
Given its unique characteristics, the non-explosive product is suitable for use in breaking rock and concrete in sensitive locations or in built-up areas. Examples of use include: secondary boulder breaking; dimension stone quarrying; and pass and boxhole excavations.
Inmet Chooses PITRAM Software Solution
Perth, Australia-based software and solutions provider Micromine said it has been retained by Cayeli Bakir Isletmeleri, a subsidiary of Inmet Mining, to supply and install its mine production control solution, PITRAM, at the Cayeli mine in Turkey. Micromine said PITRAM will increase operational efficiencies at Cayeli by capturing data in real-time and improving the site's reporting capabilities. The first stage of implementation is expected to be complete by late December 2010.
PITRAM, said Micromine, is capable of managing and coordinating all functions within a mine site, including mine development, production, equipment and maintenance. PITRAM tracks and reconciles the delivery and quality of the ore and provides production and activity reports in real time, allowing key personnel to view and monitor the location and status of all equipment and personnel.
The implementation of PITRAM at Cayeli, an underground copper and zinc mine located on the Black Sea coast of northeastern Turkey, was due to begin in early November. The PITRAM Voice System will be operational by the end of December 2010. Two additional modules—Grade Control and Shift Planner—will be introduced throughout 2011.
"After considering various mining solutions, PITRAM was selected due to its proven record of introducing operational improvements and increased efficiencies within underground mine sites. I have used PITRAM at three other operations and am confident that the solution will deliver positive results at Cayeli," said Cayeli Mine Manager Phil Jay.
"PITRAM users can visualize and manage all mine site operations as they occur. Micromine's Shift Planner Module will allow Cayeli to implement a production plan within a real-time environment, and use short-interval control methods to manage daily activities," said Micromine UK Manager James Hogg.
"Cayeli's material movements will be closely tracked using the Grade Control Module which enables real-time management of stockpiles. The reports available from Grade Control provide valuable Key Performance Indicators which can be used to assess the outcomes from production related Business Process Improvement initiatives.
"Through PITRAM, Cayeli will be able to identify areas of constraint and where greater efficiencies could occur. Most importantly, management will have increased control over its operation," Hogg said.


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They stopped.
He listened, one ear turned to the wind that blew little mists of sand over their feet. Then he nodded, and took three long, even strides forward.
"Nuria, I come in supplication."
One moment, nothing but empty desert beyond him—then a Fire Faerie, standing close enough that the heat off her wings made the air waver between them.
Coltzan knelt, sweeping his hat off. The Fire Faerie looked down at him, her mouth stern but for a corner turned up.
"Coltzan. You have something to ask me about?"
"Yes." Coltzan fumbled with the catch of the pouch, and then with the clasp holding it to his belt. "Here." He held out the bag.
"No—not here." Nuria looked past Coltzan for the first time, meeting the guards' eyes for just a moment as she swept the empty desert with a glance. Osiri and Raen stumbled back, pushed by the heat of her gaze. "Bring your guards if you must. Otherwise, leave them here, and follow me."
She turned, and vanished. The desert was suddenly dark, and cool.
Coltzan shed his pack. His throat dry, his voice was hoarse when he spoke. "Osiri, Raen. Wait here. I will not be long."
The Usul and Aisha shifted uncomfortably. Their orders were to follow Coltzan, but if he gave them a counter-order, was that good enough to negate it?
Neither wanted to spend more time near the blazing Faerie. They nodded.
Coltzan hadn't waited for their reply: he stepped forward. Whatever door Nuria had gone through, she'd left it open. He disappeared in mid-step, and the two Royal Guards were left in the Desert alone.
Nuria's hall was taller than it was wide: much taller, and that was saying something. Pillars caught up the ceiling around the edges, but in the center it soared up and over.
In the center of the open space, someone had set a long stone table and lined it with intricately carved chairs. In proportion to the hall, it was tiny. As Coltzan approached it, he tried to count the chairs, and failed: every time he counted one, two more seemed to appear from thin air.
It was impossible, he knew, but then that was Faeries for you.
Nuria seated herself at the head of the table, in the grandest chair, and motioned for him to sit at her right hand.
Here, far underground, the stone breathed cool air, and the heat rolling off the Faerie encountered it and fell back. Coltzan took his seat and could move, and breathe, comfortably.
"You have something to show me?"
The Kyrii nodded. He tipped the pouch over the table, spilling the rings out: they fell, and lay quiet.
Nuria looked at them for a long moment, and then put her hand out over them, as if warming it at a fire.
"I can tell you what they are called, and what they do." She paused, not looking at him. "For a price."
"Well. What do you want?"
"What do you offer?" the fire Faerie countered.
Coltzan had been expecting something of this sort. He was trying not to be intimidated. It was surprisingly difficult—but then, Faeries were more powerful than kings, and more long-lived. Some said they were immortal.
"Bargaining doesn't become you," he said. "You want one of the rings."
Nuria inclined her head.
"Tell me what they do, and I'll decide which one is worth more to me."
"And then you will give the other one to me." A glimmer of amusement sparked in her eye.
The Kyrii smiled. "No. I give you the one that is more valuable, in trust."
"In trust?"
"When one of my descendants comes here, if their need is great enough, I would request that you offer it to them. It is their choice whether or not to take it. It is your choice whether or not to offer it—but consider my request."
The Faerie nodded.
"Are we agreed?"
"We are agreed." She brought a paper out of nowhere and laid it on the table. A line of black ink wriggled across the page, leaving their agreement written out clearly. Coltzan tugged it toward him to scan it.
"It looks well enough." He pushed it back to Nuria.
"Good." She pressed her thumb onto the blank space at the bottom of the page. When she took it away, her seal was embedded into the paper: fiery red and gold, a flame whirling up, shedding sparks.
Coltzan felt inside his jacket. "Is there a quill?"
The Faerie handed him a long black feather that glinted orange and yellow in the light of the braziers. The Kyrii signed in a long scrawl.
Nuria tapped the paper, and then picked it up: there was another copy underneath. She handed the first one to Coltzan, who folded it and stowed it away.
"And now." The Kyrii leaned forward. "The rings."
She told him what they did.
"You may have as much time as you would like to decide," she said after she was done.
Coltzan nodded and stood up to pace. It was a long hall, and he'd made fifteen circuits of it before he spoke.
"Even without the ring, I can unite the Desert," he said. It echoed strangely. He was halfway across the hall from Nuria, but she nodded. She was still sitting at the table. "But Maraqua has been united for decades—centuries—a long time. They have troops. Armies. They're the clear threat.
"With the Ring of the Deep, I can summon the creatures who lie on the bottom of the ocean floor. If they all rise at once, Maraqua has no chance."
He paused.
"You have made your decision, then." Nuria stood as he approached the table. For a moment his hand hovered over the rings, wavering, and then he closed it on the Ring of the Lost.
"My thanks to you."
Nuria inclined her head.
"Good luck, King Coltzan. May your days be long and well." She stooped to kiss him on the forehead. When she straightened, there was a mark like a flame where her lips had touched his fur. "Now go. Your guards await."
The Kyrii pulled himself together and took a long stride forward. He vanished.
Nuria looked at the Ring of the Deep, and it looked back.
"He'll do well enough without you," the Faerie said. It seemed to consider this.
There were corridors stretching off the hall, if you looked the right way. Cradling the Ring of the Deep in the palm of her hand, Nuria went down a long flight of shallow stone steps to her treasure room and set the ring in a place of honor.
"And now," she told it, "we wait."
The ring's inner fire flickered, resigned to centuries of sitting on a pedestal far underground.
King Coltzan strode into camp at daybreak, followed at some distance by Raen and Osiri.
"Rise and shine, rise and shine," he murmured. Few Royal Guards were up yet: a couple of yawning Ixi walked the beat, and the kitchen tent had been active for half an hour, but the majority of the camp was still sound asleep.
Coltzan went straight to Delia's tent, and then stood outside, wondering what he would tell Delia, or any of them.
Better that he just keep it a secret for now. Leaving with two magical rings, he'd come back with one—the one less valuable to them.
He'd just have to make something up. He had reasons, but none of them would quite bear up in the bright light of day.
In Nuria's deep cavern, lit only by a few fiery braziers, they were perfectly plausible. But no, it wouldn't do to let his Guards knew he was afraid of anything—even a Fire Faerie. He was King, after all.
He wheeled around suddenly, almost knocking into Osiri.
"What are you two still doing? Get some rest," he said. "I'm going to." He strode off to his tent.
Raen and Osiri, who had spent the night huddled in the sand jumping at small noises, looked at each other. Osiri opened her mouth to ask if Raen had seen the glint of red and gold on King Coltzan's hand, and then closed it again.
They stood in uncomfortable silence for a while, and then the Aisha shook her head.
"Well—we should rest."
Raen glanced at her. "If we're asleep, they can't ask us what happened," the Usul guessed.
Osiri smiled. "Exactly. Hey—"
The Usul looked back. "Yeah?"
"If Doon wakes up, tell him I changed my mind." Osiri hesitated, but she didn't really need to say any more. The shadow Kougra took the Royal Guards' bets on whether or not King Coltzan would last the year.
Raen nodded. "If you run into him first," the Usul added, "tell him for me."
The Aisha grinned. "I will."
To be continued...


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Zach Colman, The Founder Of Creatitive Branding And Marketing Agency, Is Revolutionizing The Way Athletes & Sports Companies Market Themselves To Leverage Growth
Creatitive Branding and Marketing Agency is the #1 full-service solution for athletes and sports companies to establish their brand identity, develop a strategic online presence, and reach their business goals.
Zach Colman, Arizona native and the founder of Creatitive Branding and Marketing Agency, has always been passionate about sports. The son of an NFL kicker and a dedicated soccer player himself, he had always hoped to integrate sports into his career. He realized his passion for graphic design early on and went on to achieve his Bachelor of Science degree in Graphic Design and Visual Communications from Arizona State University. Although he enjoyed a successful career in the corporate world and held multiple prestigious positions ranging from professional designer to art director, his desire to offer a revolutionary service to athletes and sports companies prevailed. In 2015 he left the corporate world to found his own company, Creatitive Branding and Marketing Agency, the culmination of Colman's greatest passions: sports, design, and marketing strategy.
Although business advisors warned Colman that a sports marketing agency was far too niche, he was confident that the value he could bring to athletes and sports companies would be both impactful and prolific. Indeed, Colman's instincts were correct. Today, Colman and his team partner with multiple high profile athletes and sports companies offering BrandBuild, web design, strategy, and digital marketing services.
When working with new athletes looking to grow their brand and further establish their identity, Colman takes a simple, yet strategic approach. Although it may not be the natural inclination, he advises athletes to approach their sports career as a business. The first step should be leveraging the free marketing they are receiving on the field or the court.
As Colman points out, "What's the point of having an online presence if you're not leveraging it?"
Athletes possess a unique value, set apart from traditional businesses; they already have the audience, they simply require the tools to cultivate their existing audience to their advantage. Once they do so, athletes are equipped to bring value to their existing sponsors while also attracting new sponsorships and brand deals.
Often, athletes lack the vision to identify what it is their target market is looking for.
Colman is clear, "I'm not here to be your yes-man, instead I'm going to show you exactly what it is your audience wants and needs from you, not the other way around."
In developing a solid brand identity, athletes will be better equipped to attract their ideal audience, build brand awareness, and eventually turn fans into paying customers.
However, Colman warns that the path to success isn't always as easy as some marketing gimmicks will make it seem. Quality processes achieve quality results. While many will assume that social media will be the key to their success, in reality, it is much more complex than that. The most successful athletes and entrepreneurs recognize that brand identity, SEO (search engine optimization), blogging, and paid marketing all play into their business success.
In the same way a quarterback wouldn't enter the field without a solid plan, nor does Colman and his team at Creatitive enter into any new partnership without a solid playbook. Indeed, there is a thoughtful strategy attached to each decision they make.
Colman shares the following analogy, "If you score a touchdown, who threw you the pass? Business is our sport. We want to be on your team, throwing you the right passes to help you grow your business and achieve maximum results."
To partner with Colman or inquire about Creatitive Branding And Marketing Agency's services, visit https://creatitive.com.
Media Contact
Company Name: Creatitive | Sports Digital Branding and Marketing Agency
Contact Person: Zach Colman
Email: Send Email
Phone: 602.935.0767
City: Gilbert
State: AZ
Country: United States
Website: https://creatitive.com


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You know, I was a little disappointed when I learnt that this was to be Pixar's next film. Sure, Toy Story and Toy Story 2 were huge achievements in both animation and the kids' movie genre, and a great substitute for the ailing Disney 2D animation that was becoming less and less interesting throughout the 90s, but then they made brilliant original films like The Incredibles. And Wall-E. And Up. And even Ratatouille, to a lesser extent. To see Pixar returning to the well was a bit of a letdown. And whilst watching Toy Story 3, I felt the same way. I mean, it's really good, possibly on par with the first two (and this franchise surely sports two of the best sequels ever made), but it just felt like more Toy Story, something which I hadn't ever craved.
Then, in the last 20 minutes, this film blew me away. As with Up and Wall-E, this film had me in tears, and it's astounding just how emotive Pixar can be when they put their mind to it.
Of course, the animation is great. I honestly couldn't be bothered paying extra for the privilege of 3D, so I just saw this in regular D (surely this gimmick isn't going to last. Aren't we at saturation point now?). In keeping with the style of the first two films, this Pixar feature is probably the least visually interesting since Cars, but one can see the advances made in other areas such as character physics and expressions.
I suppose I could tell you that this film takes place a fair while after the second – their owner is 17 now and the toys are wondering if there is Life After Andy – but then again, people are going to see this film regardless of the plot. There is a huge collection of new characters in Toy Story 3, though I never felt swamped because the characterisations are so clear cut (I just can't begin to imagine the amount of work that goes into getting legal clearances to use the trademarked toys).
Some of the wonder may have dissipated, and after two previous films, the creators have to work harder to impress us with the amusing acrobatics employed by toys moving around a human world, but Toy Story 3 is still a solid feature. Basically, the last section of the film made me glad that they made a third entry for the franchise.
With this sequel out of the way, I was hoping that Pixar would resume focussing on original narratives, but it seems both Cars 2 and Monsters Inc. 2 are on the way *sigh*.Rating:


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As citizens of the 21st century, we live in amazing times. People alive today—especially those living in modern, industrialized nations like the United States—have available to them to a whole range of scientific knowledge and technologies, ranging from advanced health care to laundry detergent and from cell phones to clean drinking water, that can make their lives better. So many aspects of our everyday lives have been touched by science.
In the weeks surrounding the March for Science on April 22, 2017, in Washington, D.C., and around the country, we invite you and your students to consider the impact science has had in your everyday life through the #ScienceInMyLife campaign. AAAS and Science NetLinks have created several resources that encourage students, teachers, and the public to identify the impact of science in their everyday lives:
- A short video identifies some of the things science has given us.
- A PDF printout asks students to draw, write, or otherwise convey the importance of science in their lives.
- A lesson that, using both of the above resources, explores the ways science impacts our everyday lives and invites students to reflect upon the science in their own lives through research and a creative presentation.
Should you, your family, or your students use any of these resources, we'd love to hear back from you. Share with us via your preferred form of social media using the hashtag #scienceinmylife. You can tag Science NetLinks on Facebook, Twitter, and Tumblr.


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Tom Kerridge's popular Pub in the Park festival is coming to Kent
PUBLISHED: 15:01 12 March 2018 | UPDATED: 15:01 12 March 2018
CMatthews Photographer
TV chef Tom Kerridge is bringing his new food and drink festival Pub in the Park to Tunbridge Wells
When Tom Kerridge walks through the door of Sankey's restaurant in Tunbridge Wells for our meeting, it's hard not to beam as if at an old friend.
Despite the dramatic weight loss (he's gone from 30 stone to 18 by cutting out carbs and alcohol), the celebrity chef remains one of the most recognisable faces on TV and is as likeable in person as he comes across on screen.
"Alright, mate?" he greets me in his lovely West Country burr, as he proceeds to tell me about his new venture, Pub in the Park, which launched last year in his home town of Marlow and is now coming to Kent this summer.
That first event sold all 18,000 tickets in 24 hours and the organisers are hoping for more of the same at Dunorlan Park, when the heady mix of great food, live music, shopping and chef demos is brought to the outskirts of Tunbridge Wells on 6-8 July.
The loyal 'Marlowvians' are being treated to another glorious festival feast in May, then it's on to Bath (8-10 June) and Tunbridge Wells, which will see chefs from both events (including Tom's own Michelin-starred pubs, The Hand & Flowers and The Coach) – plus a handpicked quartet of Kent's finest.
And alongside such luminaries as "great mates" Steve Harris of Michelin-starred The Sportsman in Seasalter (where Tom has a holiday place) and Mark Sargeant (bringing Spanish delights from the transformed Wife of Bath) and the Tanner brothers (The Kentish Hare), I am delighted to see my friend Rob Taylor of The Compasses at Crundale.
He's looking a little 'rabbit caught in the headlights' sitting next to Tom, but says he leapt at the chance when he got the highly unexpected 'call' and that his customers are already very excited for him.
Tom explains: "This event is not all about showmen, it's about great food. That's what is separating Pub in the Park from other chef-led cookery festivals. This is a celebration of food that includes great music – and represents Kent, which Rob does brilliantly."
The original idea came from talks with his business partner Chris Hughes. "It started off as tenth birthday celebration for the Hand & Flowers but it took so long to organise three years went by and we'd missed that landmark moment," laughs Tom.
"But the more we thought about it and structured it, the better the idea got and it became a proper celebration of British food, not just the pub."
He adds: "The first one was all people nearby who I knew really well and are great mates, so they're coming with me plus wherever we go we'll work with chefs I know and who are making great use of local produce."
As well as Tom on stage, expect to see his friend Angela Hartnett ("she'll just rock up and do something amazing"), Paul Ainsworth, Atul Kochnar (the first Indian chef to receive a Michelin star) and other household names.
Each pub set-up will do three different dishes, which you can sample at £5 each. So you could set a budget of, say, £30 and wander around choosing six Michelin-star quality dishes for lunch.
And then of course there's the music on Friday, Saturday and Sunday evenings. Confirmed acts include Tom Odell, Toploader, Razorlight, Mel C and Scouting for Girls – rather different to Tom's music of choice.
"At the moment I'm listening to Men of North Country signed to the Acid Jazz label. I like a lot of Indie/Mod stuff too. But I'm a big fan of all music."
Both Tom and Rob have young sons ("by 8pm last year my little man Acey was out of it!" laughs Tom) and love that the festival has a proper family feel, with five hours each afternoon to wander around with younger members.
"The most important thing for us is that the people of Tunbridge Wells and Kent love it," says Tom. "It would be deemed a success for me if Rob here came away telling me he and his customers had had a fantastic time."
Pub in the Park
Where: Dunorlan Park, Pembury Road, Tunbridge Wells TN2 3QN
When: 6-8 July 2018
Sessions (five hours each): Fri eve, Sat pm, Sat eve, Sun pm and Sun eve: timings tbc