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Heavy-handed sentiment and political messages never make for a great movie, and terms like "Important Film", "World War II Propaganda", and "Interesting Failure" come to mind when Dragon Seed (1944) is mentioned, but it's no less a fascinating experiment. Based on the Pearl S. Buck novel, it's the story of Ling-Tan (Walter Huston) and his family, the simile-and metaphor-spouting denizens of a Chinese village and the impact the Sino-Japanese War has on them.
Putting aside the whole controversy of westerners playing Asians, Kate gives an unremarkable performance even though the role of Jade was an opportunity for her to spout her independent, proto-feminist beliefs as well as a chance to publicize the Chinese war effort. The Chinese portrayed here would later be Communists and not exactly a United States ally, but that would be the case with the Soviet Union, too; it's funny how politics work: your ally becomes your enemy and your enemy becomes…okay, you get the idea.
Still, this was 1944 and World War II was well under way. The war in China had been raging full on since 1937 (or 1931 if you count the conflict in Manchuria), when this film takes place, and China was suffering massive casualties while under siege from Imperial Japan since 1937. Hollywood tends to act years after the fact, just as they did in the production of For Whom the Bell Tolls (1943), though the republican faction in Spain had long since been vanquished by Franco's forces. With Dragon Seed, at least the struggle continued in China and perhaps the film could bring attention to this ally in the East. There was great sympathy for China and the Soviet Union during the war, and when watching Dragon Seed it's best to keep that context in mind. The film is interesting more for its historical context than its dramatic power. It is also regrettable that the westerners portraying Asians is a distraction, even to those of us who dwell among the anointed ones flowing over with much wisdom. Sorry, I've been watching Dragon Seed…
Katharine Hepburn receives top billing as Jade, the curious and free-thinking wife of Ling-Tan's middle son Lao (Turhan Bey) and who wants to stand up to the invading Japanese. Or to be more specific it's Katharine Hepburn playing herself in Asian-style makeup. You have to give Kate a ton of credit for trying vastly different roles; in our previous Hepburn performance review, she played a boy (in disguise). Jade longs to become educated and is interested in world events, especially the Japanese invasion. Hepburn's first scene is at a propaganda film showing with what is probably a communist political officer narrating a newsreel of Japanese atrocities and is imploring the complacent Chinese farmers to act.
Hepburn is unremarkable in the role though she earnestly tries to become the character; but it just doesn't work. She's alternately coy, evasive, and downright flaky! There are some genuinely bizarre facial expressions, too which I found to be distracting. Jade is supposed to be shy in her admissions in wanting to be "of the new" and the modern and she's full of so many deep, meaningful thoughts: "My thoughts are like a chain and one is fast to the other." See? Jade is complex! She contains multitudes! Unfortunately, Kate delivers much of her dialogue as if she were in an opium-induced trance. I'd love to know what Hepburn did to prepare for this movie.
Dragon Seed, despite some manipulative yet effective scenes, is more a historical curiosity, one that was borne of public conscience and war aims rather than cinematic achievement. It was perhaps more important for Katharine Hepburn to be associated with this film's purpose—the support of China—than it was to give a memorable performance. She lent her name and her presence to the project but she's off the screen for long stretches, one as long as thirty minutes. Much of that time in the film is spent on showing the Japanese pillaging and destroying and being evil. It's easy to rail against the depiction of the Japanese in the film, but this was after all the same campaign that brought The Rape of Nanking.
Dragon Seed airs on Turner Classic Movies June 23 @ 6am EST.


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Always with You Pendant
In your heart is a memory, and there it'll always be! Our Special Edition Always with You Pendant is a beautiful keepsake pendant designed to hold the memories that are dearest to you. A delicate and unique screw-top closure securely holds sand from a special family trip, a treasured fabric remnant, ashes of a loved one or pet, or a scrolled note with a cherished message. Wear this pendant on our Special Edition Silver 36"/18" Studded Convertible Chain for a striking look that keeps your treasured memories close to you heart.
How-To Fill:
1. Untwist the unique screw-top closure.
2. Gently add your treasured item to the pendant. A small funnel is recommended.
3. Replace the top and tighten to secure.
4. If a permanent seal is desired, add a small dab of super glue to the top edge of the closure before securing the top. Please note, this step is optional as sealing with glue will void the jewelry's warranty.
- Size: 12mm x 51mm
- Material: Stainless Steel
- Metal Finish: Polished Silver
- Threaded Twist Top
- Chain not included. To complete the look, slide on a Simple or Custom Chain.
- For those who wish to fill with the remembrance of a lost loved one it is also an option to request a crematorium or funeral home to assist with filling, most are happy to assist.
- Giving as a Gift? The Packaging includes instructions to fill and seal the Pendant.
- Includes free gift-ready packaging

subset: commoncrawl


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Over a Decade of Design, Printing, and Imagery!
From Banners to Signs, to Decals and Vehicle Wraps, Extreme Exposures offers a wide variety of products and services for your business or personal use! Here you can learn more about the products we offer as well as view examples of each.
Large Format Printing
Our 54" 8-ink Mimaki large format printer allows us to produce in-house printed materials on various grades of adhesive-backed vinyl, great for decals, signage and vehicle graphics. Another product line printed off the Mimaki is printed vinyl banners of various grades and finishes. From 30" wide to 54" wide banners and any length, printed vinyl banners deliver photo quality images to deliver your message in a BIG way! Specialty materials like artist canvas for cost-effective reproductions of fine art and photos, translucent adhesive vinyl for backlit signs and reflective vinyl to name a few can also be produced in-house at Extreme Exposures.
Graphic Design
If it needs to be printed, we can design it! Graphic design for commercial offset printing, digital copying, screen printing, embroidery, sublimation or the internet. Over 20 years of experience with multiple forms of reproduction enable us to deliver commercial designs that reproduce consistently and true to it's original design. Artwork designed for the internet will not reproduce well in most commercially printed mediums. Our original designs are designed specifically for your needs.
We will take our designs and printed materials and work with clients to develop marketing strategies and concepts to maximize your investment in your designs, printed materials, web presence and social media. Everything a Madison Avenue agency delivers except the monsterous price tag!
Our content management software (CMS) site ExtremExposures.net is a work in progress. We are blessed to have a constant flow of projects coming through the door and through the e-mail inbox, so content updates on the site take the backseat to our clients' projects. More detailed information about the product choices of our large format printing services is being added to help you make the best choice for your printing needs.
We recognize the site's importance to potential clients of Extreme Exposures, but we feel that this modernized, half finished web site still represents our company better than the old, outdated HTML web site of the past. Thanks for checking us out.
Mike Key, Owner
Extreme Exposures


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When the Maryland women's basketball team steps onto the court Monday night for its NCAA tournament second-round game at Comcast Center, the Terps will be without two starters and a reserve because of injury and another starter who's recovering from illness.
Maryland (25-7) has withstood playing with diminished numbers for much of the season to earn a No. 4 seed in the Bridgeport (Conn.) Region, and the six to seven players comprising the regular rotation have grown accustomed to performing at their peak despite logging extensive minutes.
It's an unusual circumstance the Terps' next opponent understands just the same. Fifth-seeded Michigan State (24-8) is missing four players but won 20 games for a 10th consecutive season, the longest active streak in the Big Ten, and were able to advance to the conference championship game for the second time in program history.
"I think obviously from both teams, they're terrific stories," Maryland coach Brenda Frese said. "And it says a lot of about the student-athletes involved in both programs in terms of not using the injuries as an excuse and overcoming adversity. The teams are mirror images of each other."
Maryland absorbed its first injury Oct. 20, when sophomore Brene Moseley tore the ACL in her left knee during a scrimmage. She was in line to become the starting point guard following the graduation of Anjale Barrett.
A month later, starting shooting guard Laurin Mincy tore the ACL in her right knee during Maryland's 90-71 road victory over then-No. 21 Nebraska in the ACC/Big Ten Challenge. The junior was second on Maryland in scoring a year ago and had 21 points and a career-high 12 rebounds in an 81-74 victory over Texas A&M in last season's regional semifinals.
In between those injuries, reserve center Essence Townsend became the third player to suffer a season-ending ACL tear.
The final blow to the roster came when freshman forward Tierney Pfirman dislocated her kneecap in practice Jan. 19, just hours before the team was to depart campus to board a flight to Atlanta for a game the next afternoon against Georgia Tech. Pfirman came back to play in four games but has missed the last three with mononucleosis and is out indefinitely.
"I think the coaches did a really good job of keeping us together and keeping us focused," said Maryland forward Malina Howard, who's averaging nearly 25 minutes as a freshman. "After one injury, they would give us something motivational to remind us that even when bad things happen, it makes you stronger."
Spartans coach Suzy Merchant has employed similar tactics to keep her charges' spirits high despite four players lost to season-ending injuries. She's reduced the frequency and length of practices and often has players only watch film in order to provide extra time for rest and recovery.
"I think we might be battling Maryland for most walk-throughs," Merchant said. "It's like the NBA."
Redshirt sophomore Madison Williams has been out all season since tearing the ACL in her left knee. The 6-foot-7 center and high school All-American sat out all but three games last season after tearing the same ACL Nov. 15 and missed all of 2010-11 with a torn right ACL.
Freshman guard Aerial Powers tore the Achilles' in her left ankle during practice six days after Moseley, and classmate Branndais Agee tore the ACL in her right knee at practice Dec. 13. Powers was in line to be a starter, and Agee had been working her way back into the rotation after missing the first four games with a stress fracture in her left foot.
Most recently, reserve freshman forward Akyah Taylor suffered a right orbital fracture and will miss the rest of the season.
"I think the one core thing that we see in our teams, each one of us, is that the kids that are playing, they're not going to make any excuses," Merchant said. "They just go out there and fight and compete and challenge themselves to be the best they can be and have every intent to go out there and win the game regardless of the circumstances."


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21 January, 2013 | (01 hr)
Sign In to access this Webcast
Organizational change management is a difficult topic to get our head around. There is no right or wrong in this field, but there are gurus and patterns that every practitioner builds on.
Rather than talking about 'the history of' or 'the truth about' we prefer to make a sample of 20 shortcuts. Some shortcuts refer to schools of thought, others refer to simple things that you can use immediately after this webcast.
- Learn about the origins of organizational change management
- Receive practical advice
- Know which resources to turn to for more
Luc Galoppin
Luc Galoppin is COO of MedeMerkers and Managing Director of Reply Management Consulting. He picked up his organizational change skills on projects with different scopes and user communities and interim management assignments. He is the co-author with Siegfried Caems of the SAP PRESS book Managing...Full Bio
Andrew Tank
Andrew Tank is responsible for The Conference Board's membership in Europe, the Middle East and Africa. Associate Members receive on-going research in the fields of productivity, corporate governance and organizational effectiveness, information services and access to exclusive peer g...Full Bio


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2004-2006 Subcommittee: Analytical Utility of Campylobacter Methodologies
Subcommittee Members
- Dr. Daniel Engeljohn, Working Group Chair
- Dr. Gary Ades
- Dr. Peggy Cook
- Dr. Patricia Griffin
- Dr. Walt Hill
- MAJ Robin King
- Dr. Ann Marie McNamara
- Dr. Jianghong Meng
- Dr. Dale Morse
- Dr. Eli Perencevich
- Dr. Irene Wesley
- Dr. Donald Zink
Background and Work Charge
Campylobacter spp. has been characterized as among the top bacterial agents of human foodborne gastroenteritis. Poultry is a primary reservoir of Campylobacter spp. and studies show that prevalence may be more than 80% in commercial chicken carcasses. Data show that 95% of human illnesses associated with campylobacterosis are caused by C. jejuni, followed by C. coli comprising 4%, and other species comprising 1%. Currently, the Food Safety and Inspection Service (FSIS) has conducted but not published baselines focused on Campylobacter studies of poultry and there is no performance standard for Campylobacter spp. for any Agency-regulated products, including poultry.
Previously, at the August 28, 2002, National Advisory Committee on Microbiological Criteria for Foods (NACMCF) meeting, a work charge relating to Campylobacter was introduced. The presentation consisted of three talks outlining: the methods and resulting data from previous Campylobacter baseline studies performed in 1994-1995 and 1999-2000 by FSIS; available laboratory methods for Campylobacter spp.; and Campylobacter cell aggregation (transcript available at http://www.fsis.usda.gov/ophs/nacmcf/2002/transcript082802.pdf ; PDF Only).
The original charge included three elements:
- Review and compare the methodologies used for Campylobacter detection in the 1994-1995 and 1999-2000 baseline studies in young chickens.
- Evaluate them for the accuracy and precision that they provide in assessing the prevalence and quantity of Campylobacter on chicken carcasses.
- Compare the methodologies used in the two studies with recent methodological advances for their ability to provide data on the presence and quantity of Campylobacter for application in risk assessment and the establishment of baselines.
The subcommittee met and discussed the topic but no report was presented. The baseline data have never been released due to Campylobacter methodology concerns expressed by FSIS.
In the past, FSIS has used a labor intensive and resource consuming most probable number (MPN) method for the detection and enumeration of Campylobacter spp. Current literature indicates that when Campylobacter spp. are present, their numbers per ml of carcass rinse can vary from 1 to 3 log CFU and therefore direct enumeration on agar plates can be an alternative to MPN methods. The Food and Drug Administration (FDA), the Centers for Disease Control and Prevention (CDC), and industry constituents currently use methods incorporating selective plating to detect and/or enumerate Campylobacter spp. from clinical and food samples. FSIS currently, in cooperation with the Agricultural Research Service (ARS), is conducting a special project with Campylobacter spp. detection and enumeration as part of the project. The ARS method entails aseptic whole bird rinses with 100 ml of buffered peptone water followed by storage and overnight transport of rinses at 4°C ± 4° to the laboratory for analysis. (Note: FSIS Hazard Analysis Critical Control Points (HACCP) verification samples for Salmonella use 400 ml of buffered peptone water. Based on preliminary results from the ARS project, the higher volume of rinsate used in the FSIS HACCP verification program may contribute to a lower prevalence of Salmonella in broiler rinses as compared to the ARS project). The rinses are serially diluted and plated onto Campy-Cefex agar with Bolton broth enrichment and selective agar plate streaks as a backup for presence/absence using a customized atmosphere of 5% O 2, 10% CO 2, and 85% N 2 in sealed bags. Presumptive colonies are then examined microscopically and confirmed using a serological latex agglutination test confirming C. jejuni, C. coli, and C. lari. Confirmed cultures are then stored at -80°C in Brucella broth and glycerol for possible subtyping at a later date.
Current Charge to the Subcommittee
In the near future, the Agency will conduct a baseline study looking at prevalence and enumeration of Campylobacter spp. of known importance on poultry (possibly including carcasses, parts, and ground product).
It is currently proposed that the study will focus on thermophilic species, C. coli and C. jejuni, because these human pathogens account for the vast majority of laboratory confirmed Campylobacter infections. An additional justification for this focus is derived from the numerous microbiological studies of poultry products that indicate that these two species are the only species of Campylobacter that are routinely isolated from chickens. Although some of the other 16 named Campylobacter species are reported to cause occasional human illness, the burden of human illness is low and poultry have not been shown to be a reservoir of infection. Many of these other Campylobacter species require specialized growth conditions, such as atmospheres containing 5% H 2 (i.e., non-thermophilic Campylobacters) or growth media other than Campy-Cefex agar, which contains the antimicrobial cefoperazone that inhibits growth of C. upsaliensis.
The Agency seeks advice on the proposed Campylobacter methodology, as well as any other relevant methodology that may be of equal or greater value and should be considered, for the upcoming baseline study.
The questions to be addressed are:
- What additional circumstances should be considered in order for FSIS to conclude that the poultry baseline study should address more than the two principal Campylobacter species of C. jejuni and C. coli?
- How can the ARS method be most successfully used for high volume analysis in the conduct of a baseline study of Campylobacter presence and enumeration on poultry (chicken, turkey, goose, etc.) carcasses, parts, and ground product that may lead to a potential performance standard or guideline for the regulated industry? What if any modifications should be made as a result of discussing this method in comparison with others presented to the Committee? Please consider whether the above described atmospheric conditions, media, and pre-enrichment, and storage media are acceptable for the objective of this baseline study.
- To utilize FSIS resources efficiently and effectively, FSIS expects to maintain as much continuity as possible between the current broiler rinse sampling for Salmonella and the proposed sampling for Campylobacter spp. What concerns regarding the Campylobacter spp. sampling method need to be attended to in order to properly address post-chill injured Campylobacter spp. cells as well as viable non-culturable (coccoid) cells?
- What further subtyping methods should be performed on confirmed cultures (restriction fragment length polymorphism (RFLP), amplified fragment-length polymorphism (AFLP), pulsed-field gel electrophoresis (PFGE), ribosomal DNA sequencing, antibiotic susceptibility, etc.), and what, if any, limitations do any of these methods pose?
- What effect would in situ Campylobacter spp. cell aggregation have on the accuracy and reproducibility of enumeration counts and is there any remedy to address this issue?
- Occasionally non-thermophilic Campylobacter species cause human illness. It is unclear whether livestock and poultry are reservoirs for these species, or if they are present on meat and poultry products following slaughter and processing. Current methodologies use selective agents and incubation conditions which may reduce their detection. If a pilot study was conducted to ascertain the presence of these species on meat and poultry products, what methodologies would best detect these species?
Analytical Utilities of Campylobacter Methodologies (Sep 28, 2005; PDF Only)


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* denotes required field
The wild eyed southern boy himself, Tracy Smothers sits down with Steve Corino for a can't miss edition of Old School. Tracy pulls no punches with the 4-5-6 kid (his nickname for Steve for the past 15 years) and shoots on everything from literally kicking the shit out of a guy to the rat code of ethics. Tracy shares some of his wild and crazy times from the past 30 years on this action packed episode of Old School.
Stories Include:
Total Run Time: 2:07


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Martin Scorsese seems like a most unlikely candidate to offer you something to alleviate your Harry Potter withdrawal. And yet, the first trailer for Scorsese's Hugo positively screams "Hogwarts Methadone."
It's full of beautiful imagery, funny moments... and yes, sense of wonder. With lots and lots of steam. The clockwork robot with the heart-shaped keyhole looks even more beautiful than we'd dared hope. And it appears that Chloe Moretz is capable of being neither creepy nor profane, and yet still awesome. Who knew?
This movie is based on The Invention of Hugo Cabret by Brian Selznick, a children's book that's loosely about the life of Georges Méliès, who made A Trip to the Moon, one of the first science fiction movies.


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Surprised, right?!
I am too but all designers can be coaxed over to the "denim side" at one point or another...
See for yourselves.
Way back when, I went to his shows and even backstage where I was as close as close can be to the slight and demure designer with his trademark pearl necklace...so obviously it comes as a surprise when the designer who "doesn't do dress down"...is collaborating with :
"7 For All Mankind" ....for a capsule denim meets couture collection.
Expect animal print (see above) skinny jeans (yes...above) and tailored tops....(erm...above?)
I love his flamboyance but this collection isn't for me...but it could be for you, No?
Recent Posts
Tuesday, 10 March 2015
GIAMBATTISTA VALLI does Denim....
Posted by Reem Adeeb


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4790 W. 16th Street, Indianapolis, IN 46222
(800) 822-4639 (317) 492-6700 Mon-Fri, 9a.m.-5p.m. ET
May 15, 2021
October 09, 2013 | By Dave Lewandowski
Team Penske has added a third driver with big oval experience to its lineup for the MAVTV 500 INDYCAR World Championships in an effort to secure Helio Castroneves the IZOD IndyCar Series championship.
AJ Allmendinger will drive the No. 2 IZOD Team Penske car in the season finale Oct. 19 at the 2-mile Auto Club Speedway in Fontana, Calif. He competed in five races in the first half of the season, with a best finish of seventh (led 23 laps) in the Indianapolis 500 Mile Race after starting fifth. Allmendinger made his series debut at Barber Motorsports Park in early April, starting 10th and finishing 19th.
"I'm looking forward to racing the IZOD Chevy in the INDYCAR season finale," said Allmendinger, who will make his sixth IZOD IndyCar Series start for Team Penske. "It's always a great opportunity to compete for Team Penske and I had great time and a solid result racing the IZOD car in the last 500-mile race back in May at the Indianapolis 500. Hopefully, we can close out the season with another good finish for Team Penske and for Chevrolet."
Allmendinger will join Castroneves and Will Power, winner of two of the past four races, on the starting grid. Castroneves enters the 250-lap race 25 points behind championship front-runner Scott Dixon of Target Chip Ganassi Racing. Dixon needs to finish fifth to claim his third series title.
"AJ has been a good addition to our team this season and he was terrific racing the IZOD Chevrolet in the Indianapolis 500," team owner Roger Penske said. "With his experience racing on the Auto Club Speedway oval in the past we believe he will be very competitive as we try and end the season with a strong result for Team Penske."
Allmendinger won five races in Champ Car from 2004-06, but the 31-year-old California native hasn't competed at the speedway in an Indy car. He's driven there often in stock cars. In addition to his IZOD IndyCar Series races, Almendinger has earned two victories while competing with Penske Racing in the NASCAR Nationwide Series this season.
Chevrolet enters the last race of the 2013 season tied with Honda in the IZOD IndyCar Series manufacturer's championship. Each engine supplier has produced nine victories on the season so the winner at Auto Club Speedway will claim the series manufacturer's title.


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Savannah Events, Coupons, Reviews!
Walt Disney World Resort Orlando, FL 32830
May. 1st - Dec. 31st
SAVE on Tickets to WALT DISNEY WORLD - ONLINE ONLY - Tickets starting at $42 - You cannot redeem this coupon at the entrance or ticket window. You must go to https://www.orlandofuntickets.com/Magic-Your-Way-Tickets/ to receive your discount and purchase your tickets.
Expires: Jan. 31st, 2020
Oct. 1st - 31st
"ABSOLUTELY HALLOWEEN is ABSOLUTELY GREAT!" raves showmag.com. "An absolute family treat!" exclaims The Tolucan Times. It's the classic Family Theatre Halloween musical for Kids 2 to 102 - On-Demand so you can watch it right in your own living room, kitchen, den - wherever and whenever you like. It's the heartwarming Rudie-DeCarlo tale of the aptly-named Candy, a sweet young girl who learns some surprising lessons about life, love, laughter, and sugar, from a delightful array of characters who take her on a magical All Hallow's Eve adventure. Help Cattypuss, Patty Patches, Stuffy Steve, Lester the Jester and Fifika the French Fortune Teller happily save Halloween for one more year.
ABSOLUTELY HALLOWEEN is one in a series of original Rudie-DeCarlo fairy tale musical comedies that make up the award-winning Family Theatre Musical Matinee Series for Kids 2 to 102 now celebrating its 51st year as it cuts across the imaginary generation gap by providing an experience the entire family can enjoy.
Helmed by Graham Silbert from Chris DeCarlo's original direction, with book, music & lyrics by DeCarlo, Evelyn Rudie & Matthew Wrather, ABSOLUTELY HALLOWEEN features Celeste Akiki, Tiffany Haile, Sarai Jimenez, Mei Tam, Rodney Walker, with special guest Cate Johannessen from the UK and Silbert as everybody's favorite feline Cattypuss. The ingenious costumes are created by Silbert and award-winning designer Ashley Hayes, with production and graphic design by The Attic Room. What's the one holiday show you absolutely cannot miss? ABSOLUTELY HALLOWEEN of course! October 1-31 only!
Santa Monica Playhouse is supported in part by the City of Santa Monica and the Santa Monica Arts Commission, the Los Angeles County Board of Supervisors through the Los Angeles County Department of Arts and Culture, the Ahmanson Foundation, the Rotary Club Foundation, and Playhouse PALS.
Oct. 10th - Dec. 27th
Free Mini Photo Session with A Local Photographer
Free to book! Capture you and your loved ones (furry ones included!) with fun 30 minute photoshoots with vetted local pros.
Sessions available every Saturday and Sunday. Multiple locations to choose from. Select the date, location, and time slot that works best for you.
Book your session here: http://bit.ly/FamilyPhotoShoott
Sessions are complimentary to book and last 30 minutes.
Receive a digital gallery of 40+ high-res photos to choose from 3-5 business days after your session.
Pay only for the ones you love at $15/photo with package deals of $120 for 10 photos or $240 for your entire gallery of 40+ photos. All photos in your gallery will be adjusted for color, lighting, and cropping.
Rated 4.98 Stars on FB, Google & TripAdvisor
About Shoott
Shoott is a female-run company that seeks to make professional photography more accessible to everyone. Shoott offers "Insta-worthy" 30-minute outdoor photo sessions that are free to book and allow customers to pay only for photos they love at $15 per photo or less. We're able to provide quality at this price point because of how we work with our photographers.
Nov. 17th
Join us for an exciting opportunity to learn about the Premier Education Programs of the George H.W. Bush Presidential Library and Museum. Mrs. Gaona is a well-established leader of curriculum.
These programs show a new approach where students and educators begin with the fun Passport for Learning. The passport is a key to understanding the U.S. Constitution with examples from the 41st Administration.
Overviewing five programs, divided into elementary and secondary levels, this student centric approach is beneficial in teaching and understanding the Constitution in use in U.S. History.
Join us at 4:15 p.m. Central Time on Facebook Live at https://www.facebook.com/bush41library/


text: /* Blink without Delay Turns on and off a light emitting diode(LED) connected to a digital pin, without using the delay() function. This means that other code can run at the same time without being interrupted by the LED code. The circuit: * LED attached from pin 13 to ground. * Note: on most Arduinos, there is already an LED on the board that's attached to pin 13, so no hardware is needed for this example. created 2005 by David A. Mellis modified 8 Feb 2010 by Paul Stoffregen This example code is in the public domain. http://www.arduino.cc/en/Tutorial/BlinkWithoutDelay */// constants won't change. Used here to // set pin numbers:const int ledPin = 13; // the number of the LED pin// Variables will change:int ledState = LOW; // ledState used to set the LEDlong previousMillis = 0; // will store last time LED was updated// the follow variables is a long because the time, measured in miliseconds,// will quickly become a bigger number than can be stored in an int.long interval = 1000; // interval at which to blink (milliseconds)void setup() { // set the digital pin as output: pinMode(ledPin, OUTPUT); }void loop(){ // here is where you'd put code that needs to be running all the time. // check to see if it's time to blink the LED; that is, if the // difference between the current time and last time you blinked // the LED is bigger than the interval at which you want to // blink the LED. unsigned long currentMillis = millis(); if(currentMillis - previousMillis > interval) { // save the last time you blinked the LED previousMillis = currentMillis; // if the LED is off turn it on and vice-versa: if (ledState == LOW) ledState = HIGH; else ledState = LOW; // set the LED with the ledState of the variable: digitalWrite(ledPin, ledState); }}


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Channeling New Cloud Opportunities
Nov 9, 2012 5:00 AM PT
THINKstrategies, the Cloud Computing Showplace, and Rising Tide Media hosted our second annual Cloud Channel Summit earlier this week, giving executives from leading cloud and channel companies a peer-to-peer networking forum where they could share perspectives on how to forge successful partnerships to capitalize on the unprecedented opportunities created by the cloud.
This year's event attracted more speakers, sponsors, partners and attendees than our first event. More importantly, it brought together a greater mix of channel company executives to interact with those from various cloud companies.
Cloud company executives were the primary participants in our first Summit a year ago. They talked about what it would take to gain the trust and participation of existing and emerging channel partners to extend the reach of cloud services into new market segments. However, there was just a handful of channel company executives at the event because the vast majority of channel companies were not ready to respond to the growing interest in cloud alternatives.
Critical Role
At our second Cloud Channel Summit, held on Monday, a larger contingent of executives from a wide array of channel companies were on stage and in the audience. They shared information and insights about their rapidly evolving initiatives to respond to the rising demand for cloud solutions from customers of all sizes and across nearly every industry.
The Summit attracted executives from major distributors and resellers like Avnet, Ingram-Micro, Insight and Tech Data, as well as IT firms, cloud consultancies and managed service providers (MSPs) such as All Covered, Centerbeam, Cloud Sherpas and Spiceworks. Hosting and other service providers such as Comcast, Savvis and Rackspace also spoke.
What did they all have to say?
Although their cloud initiatives are still embryonic, all of the executives who participated in the Summit agreed that the channel must become more actively involved in the cloud movement for it to sustain its current growth rate and expand into new geographic and vertical markets.
The channel plays a critical role in educating customers, designing and delivering specialized solutions to meet their unique needs, and responding to their day-to-day support requirements.
Disruption and Transformation
However, the established channel companies are contending with the same challenges faced by legacy hardware and software vendors before them.
First, they must accept that the cloud fundamentally disrupts their traditional business models and be willing to take actions that will significantly change their current operations.
Second, they must recognize that meeting their customers' rising expectations requires transforming their go-to-market strategies and services. It changes the skills required, the sales tactics, the value propositions and service delivery methodologies. These changes will inevitably lead to structural and staffing shifts.
Third, migrating to cloud services will impact their financials, converting product revenues into subscription service fees that place greater economic pressure on the way channel companies operate.
Despite these significant challenges, the channel companies that participated in the second annual Cloud Channel Summit were proud of their progress and happy to share their experiences and success stories. They were also committed to making further investments into converting their operations to become more efficient and effective cloud service providers going forward.


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By Tim Wogan, ScienceNOW
Smarty-pants slime molds can solve mazes and produce diagrams similar to the Tokyo rail system—and now, scientists suggest, they may also be able to help treat cancer. Biophysicists in Germany and Singapore suggest that mathematical models based on slime mold behavior might lead to new ways to starve tumors of blood.
The slime mold Physarum polycephalum, usually found growing inside rotting logs, forages for food by extending a network of thin tendrils from its edge. Once the mold has found food, such as a piece of decaying vegetation or a microorganism, it grows over it and secretes digestive enzymes. P. polycephalum then constructs an elaborate network of interconnections between food sources, allowing it to shuttle nutrients around.
In 2010, mathematical biologist Toshiyuki Nakagaki, now at the Future University Hakodate in Japan, and his colleagues observed how this networking behavior might translate to efficient city planning; they placed the mold in a laboratory culture that also contained a scale model of the region around Tokyo, with food sources representing population centers. The slime mold's tendrils, they found, produced interconnections strikingly similar to the layout of the Tokyo railway system.
But it's the mold's early growth, even before it forms those elaborate foraging networks, which might hold clues to understanding how tumors supply themselves with blood. Slime molds start as a collection of isolated spores; as they grow outward, the spores meet and fuse into islands. The islands send out tendrils that eventually meet other islands; when they meet, they fuse again, ultimately forming a large, single-celled organism that can now transport fluid throughout itself. There's a mathematical term for this: The point at which separate networks, each with its own transport system, become interconnected enough to allow a fluid or some other substance to move freely between them is called the "percolation transition."
To construct a mathematical model of the percolation transition, Adrian Fessel, Hans-Günther Döbereiner, and colleagues at the University of Bremen in Germany and the Mechanobiology Institute, Singapore studied the way that slime molds grow in the laboratory. Understanding how those connections form and when that transition occurs may have a practical application, Döbereiner says. To survive and grow, tumors need a blood supply; many highly invasive tumors can construct a completely new vascular system from tumor stem cells which grow, meet, and fuse before connecting to the healthy tissue's blood supply. Since the process of connection is mathematically identical to the percolation transition in the slime mold, a mathematical model of the latter should be equally valid for both, he says.
As the mold tendrils grew toward each other and joined up, the researchers used network diagrams (like subway maps) to track the connections between tendrils. They recorded how many connections radiated out from each node to get a measurement of "interconnectedness," similar to the number of subway lines that serve a particular station. Writing in *Physical Review Letters, *the scientists found that the transition from multiple mold islands to an interconnected network—the percolation transition—always occurred when the nodes and lines fell into one particular, peculiar pattern. Regardless of how many overall nodes there were, what mattered was how many of them had exactly three emerging lines, how many had one emerging line, and how many nodes remained completely isolated. For one particular ratio of those three numbers, percolation transition always happened.
"The results are very interesting and novel," says Nakagaki, who was not involved in the present work, "and the analysis by means of a standard technique of percolation is clear and beautiful."
Starving tumors of blood is a key way to attack cancers, so Döbereiner hopes that the researchers' insight into vascular network formation may one day lead to ways to inhibit the development of tumors' blood supplies and curb their growth. To demonstrate their model's applicability to vascular growth, the researchers showed that they could reproduce the results of a 2003 laboratory study into the growth of vascular networks using their slime mold-derived mathematical model.
Although reproducing that 2003 study is a useful demonstration that their model is applicable beyond slime molds, Döbereiner points out that from a mathematical standpoint, such a demonstration is somewhat redundant. The two situations—slime mold growth and vascular network growth—are mathematically equivalent, he says, and so a model that works for one is required to work for the other. "Even if we hadn't done that experiment [with the vascular network] … there is mathematically no way out!"
This story provided by ScienceNOW, the daily online news service of the journal Science.


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Infamous 2's Cole will be joined by a pair of lovely lady co-stars in Sucker Punch's PlayStation 3 sequel, two representations of the game's karma system. Meet Kuo and Nix.
Nix, pictured above, is "a New Marais native that grew up in the swamps," complete with a burning hatred borne from the murder of her family. At night, she dances at Jabba's palace for tips. Not really. Nix is your "hedonistic guide that coaxes Cole into not thinking about the consequences of his actions," according to new Infamous 2 details from the PlayStation.blog.
The other half of Cole's conscience is embodied in Kuo, an NSA agent working to help him defeat the Beast.
She's the angel on Cole's shoulder. Depending on who's lead you follow, the temptress Nix or the level-headed Kuo, the world of Infamous 2 will change in line with your actions.
inFAMOUS 2 Unveil At The PlayStation Experience [PlayStation.blog Europe]


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J: What movies made you cry, and why?
R: Haha paiseh to say lah!!
Z: C'mon lah!!
R: Errmmm. Let's see. I remember watching a Japanese movie called 'Crying out for Love in the Center of the World'. There was a boy and girl, they fell in love and suddenly the girl got sick and was slowly dying. When the girl was vey close to death, out of true love the boy proposed to marry her, in hospital and on her deathbed, even though he knew he wouldn't get to see her again for another day. I remember he even brought the marriage cert for her! And when she said yes and he cried, the music and all came on and I started crying too!! Hahaha…Very very touching. Luckily it was in the cinema haha, still very dark inside, can't see can't see…
Z: Hahah, got no "sob sob" sound one meh?
R: Got, but make it sound like I'm having a flu lah!! HAhaha
J: Like that also can!!
R: Hahahha. The other movie I remember I cried abit was also a Japanese movie called 'Cyborg girl'. Also called 'My girlfriend is a Cyborg', or 'Cyborg She' I think. There's this guy that met and fell in love with a girl, and that girl turns out to be a cyborg or robot, built by himself in the future and set back in time to met himself!! I think why he did that was because in the past he met this girl and fell in love, but he didn't have the guts to approach or talk to her. Ever since then, he grew old and alone, he really regretted it until his dying day. So, he being a brilliant scientist made a cyborg of her to bring back to the past, to allow himself another chance not only at love, but in life, to show him the mistakes he had made and hopefully learns to rectify them. In the end, when the girl had to 'shut down', the boy was reminiscing about all that he had experienced and learned about life with a second chance, and when the music came on, I just cried hahahaha….Quite a meaningful movie, if you really look into it. But luckily I was watching it alone.
Z: Ooooooh.
R: The other one was…Jeng jeng jeng!!! Titanic hahahahaha.
J & Z: Wahalooooooooo….
R: Eh, when watching it the first time it was so nice ok!! Then it got so popular until everyone was singing that song and all. Sigh, spoil the movie already haha. But the scene when Jack was clinging on to Rose on the water after the ship had sunk, Jack had died from the cold, Rose kept calling him to wake up, but he didn't, she still kept calling him to wake up, hoping he would, but in the end she had to let him go, and seeing Jack fading into the water, and that music started playing, I cried hahahhaa….Lukily, the person next to me was crying also, so no problems hahaha…can share share tissue paper hahaha….
J: Aiyooooo!! Any other movies?
R: Got la, quite a few lor. 'Winter Sonata' was so good, and then '1 Liter of Tears'. Wahlau, that one really can make you cry 1 liter of tears out from you one haha…
Z: Hahah, not corny or cliché meh these shows?
R: It's clichéd lar, but sometimes you just have to open up and let it all in. Allow yourself be taken in by it, and when you start to believe in it, then it shows you emotions that you can only dream of haha…And sometimes, who knows, you can maybe learn something from these shows too.
J: Like what?
R: Like opening up to love, I mean I see some people always so cool, like too cool for sentimentality, too cool for love. But, why not? But then again, they might have gotten hurt from love…and love is not welcomed.
J: Yes true. People are the way they are from their past experiences, the way there brought up, etc. So many factors.
R: True. So thank God I didn't have to go through many bad experiences.
Z: So that's for movies, what about in real life? What touched you most and made you cry?
R: I think it was only recently. It was during my wedding and it was at the tea ceremony. There's this auntie that I know since I was a kid. She cared for me and saw me grow up since young. And on that day, when it was her turn to present the tea to her, I was touched. There she is, from the day when she walked me to school when I was a boy in primary school, fetched me in to secondary school, she was there when I graduated in the UK, she came all the way there, until now, I am married and here she is, in front of me. When I said the words to 'cheng yamca' I was touched then, but after finishing her drink, she put the cup aside and got up and hugged me. And it was a long hug, it was a hug many, many years in the making, and I cried. It was not a sobbing cry, it was a cry of comfort and assurance, that we reached so far in the journey together, and hopefully for many years to come. Many people didn't notice I think. I looked away & continued on with the day…
Z & J: Awwwwww….ahahahhaa….
Z: Wahhh so much crying, and nothing to do with your wife one ah??
R: Hahahah. Well, for me, the most romantic thing la together with her is when I proposed and she said yes, we spent the first moments engaged underneath the sky of fireworks in Disneyland, Hong Kong. I think for me, the feeling was just perfect. The fireworks were out of this world, and the feeling with her was out of this world. And just walking around Disneyland with her, with the fairy lights and innocent laughter all around the park, it was just special for me. It was 'A Whole New World'!!! Hahaha.
J: Ooooooo…Interesting interesting…shall we talk more about your love life hmmmm? Your ex, or ex-es etc hahaha…
R: No laaaahhhh…..enough enough ahhaha
Z: Yaya, how many ah? 2? 3? 4? 5?
R: I'm a single-lady person ok!!
J: YEAH RIGHT LAHH hahaha…
Z: Quick quick tell, how one your love life. In UK sure got one ler? I heard got, Ben say one hahah…almost want to start, but didn't start one rite!!! The girl got bf already somemore!!!
R: Whatever lahhh….
The rain slowly subsides, but the questions linger much longer. Much more was said, but that's all for today. But after reminiscing through all that was asked and spoken, it's amazing how a few cups of The Tarik can bring about so many emotions, so many questions, so many words spoken. I guess it's just one of those peculiar pulls of the teh.
Coffee shop talk and all that. Until next time….
Just so you know, I've moved… - … to a new blog persona: http://majidah.wordpress.com Let's meet there:)
10 years ago


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Philadelphia: Thin-Crust Pies at The Original Tacconelli's Pizzeria
There are a few things to know about Tacconelli's before you go:
• It's strongly recommended that you call ahead to reserve your pizza dough. They make a limited amount each day, and they usually sell out over the phone. Call between Wednesday and Sunday after 10 a.m.
• Pizza is the only item on the menu, though you're welcome to bring any accompaniments you might want, like olives or salad. You may also bring wine or beer—it's one of Philly's many BYO restaurants—and if you care about drinking either of those in something other than a plastic cup, bring glasses, too. (They serve soda.)
• The hot peppers (75 cents for a small cup) are HOT.
• They only serve dinner, but it's not a late-night pizza joint; last seating is at 9 p.m. on Friday and Saturday, and it's earlier on other nights. They're closed Monday and Tuesday.
• Takeout: Yes. Credit cards: No.
• It's casual, but it's not cheap: Pies run about $20 before extra toppings.
• The restaurant sits in the middle of a crowded residential block in Port Richmond (which isn't a destination for anything other than Tacconelli's), and street parking can be tricky. Note the restaurant's parking lot one block away.
• Don't confuse this location with the one in Maple Shade, N.J. Apparently, they're family, but they're not affiliated.
• Even if you have a reservation, you'll usually wait quite a while for your pizza (that's what the olives and salad are for).
If that sounds like a lot of planning for a pizza joint, it is, but the pies are worth it. They're really thin; to look at them, you might think they're crackery, and the edges are, just a bit. But from the handle to the point of each slice, there's just enough springy, satisfying tug.
They're also sauce-heavy. That's not to say they're dripping or at all soggy, but the tomato pie, regular pie, and popular Margherita pie are first and foremost canvases for the red stuff, which is concentrated, perfectly balanced, utterly smooth, and nicely baked into the crust so that it doesn't slide off when you pick up a slice.
The menu advises no more than two toppings, which makes sense given the thinness of the crust. Personally, I'd stick with the two house specialties—the Margherita, which has a modest (but ample) amount of fresh mozzarella and some torn basil, and the signature white pie, which is actually red and green. Over a thin layer of bubbly mozzarella, there are scattered piles of fresh spinach and tomato, and more than a few shakes of garlic powder. The two make a great combo.
2604 E. Somerset Street, Philadelphia, PA 19134 (map) 215-425-4983; tacconellispizzeria.com
All products linked here have been independently selected by our editors. We may earn a commission on purchases, as described in our affiliate policy.


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Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00994344
Recruitment Status : Completed
First Posted : October 14, 2009
Last Update Posted : February 13, 2014
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV Infections
|Drug: Darunavir/ritonavir Drug: Lopinavir/ritonavir
|Phase 4
The pillar of the current standard of care for highly active antiretroviral therapies (HAART) is the use of two nucleoside reverse transcriptase inhibitors (NRTIs).1 However, these agents can inhibit the mitochondrial DNA polymerase gamma, causing mitochondrial dysfunction, which, in turn, may cause NRTI-related adverse events such as peripheral neuropathy, pancreatitis, liver disturbances, lipid profile abnormalities or lipoatrophy.2 As a result, strategies aimed to avoid the long term exposure to NRTIs and their toxicities are desirable for the management of HIV-infected patients.
Monotherapy with protease inhibitors (PIs) as a simplification approach therapy after an induction period with conventional antiretroviral treatment, appears to be of great utility for minimizing mitochondrial toxicity because of NRTIs. This approach may also increase patient adherence, reduce costs and preserve future treatment options. However, concerns remain regarding compartmental HIV replication due to limited drug penetration into the central nervous system, risk factors associated with monotherapy failure as well as the extrapolation of results obtained in clinical trial settings to routine clinical practice, are still not well known.
In this regard, there are reports that have suggested that lopinavir/ritonavir (LPV/r) monotherapy may be an effective therapeutic option for treatment of HIV-1 infection in antiretroviral-naïve patients. 5,6 Moreover, some studies report that despite LPV/r allows CSF concentrations lower than plasma, its concentrations exceed levels that suppress wild-type HIV replication.7,8,9 However other authors have reported that LPV/r monotherapy results in suboptimal HIV suppression in the CSF compartment in approximately 10% of cases.10
Darunavir is the last PI with activity against wild-type and PI-resistant HIV. In ARTEMIS trial, DRV/r at doses of 800/100 mg once daily have demonstrated that it is non inferior and statistically superior than LPV/r and it is an effective treatment option for antiretroviral (ARV)-naïve patients. In this study, patients receiving once-daily DRV/r achieved high durable virologic response rates, which were comparable in patients with less favourable baseline characteristics or suboptimal adherence. In addition, they had a low discontinuation rate due to virologic failure or adverse events or both, did not develop protease inhibitor resistance upon failure, and had suitable drug exposure. 11,12
All these benefits, coupled with the higher genetic barrier, its favourable safety and plasmatic pharmacokinetic profile of DRV/r, suggest that DRV/r has the potential to be an excellent option for monotherapy simplification strategies.
The investigators propose a prospective and randomised clinical trial that compares the efficacy, safety and tolerability of DRV/r 900/100 mg monotherapy once daily versus LPV/r 400/100 monotherapy twice daily as simplification strategy in HIV-infected patients with stable NNRTI or PI-based antiretroviral regimen and sustained viral suppression.
Aside to the main goal of this project, the investigators are going to make use of the samples obtained from the CSF at 48 weeks of follow-up (as representative of the viruses replicating in the central nervous system) and genital tract and plasma at the different time points. The investigators will compare the sequence population of those organs from the different patients in order to state if viruses not found in plasma at one time point but found in reservoirs can be found in blood when the infection advance.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|73 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Randomised and Prospective Clinical Study to Evaluate the Efficacy and Safety of Lopinavir/Ritonavir Monotherapy Versus Darunavir/Ritonavir Monotherapies as Simplification Switching Strategies of PI/NNRTI-Triple Therapy Based-Regimens
|Study Start Date :
|October 2009
|Actual Primary Completion Date :
|October 2012
|Actual Study Completion Date :
|October 2012
Experimental: Darunavir/ritonavir
to switch from the triple therapy based regimens to Darunavir/ritonavir
Drug: Darunavir/ritonavir
Darunavir/ritonavir 800/100 mg once daily
Other Name: N/P
Active Comparator: Lopinavir/ritonavir
to switch from the triple therapy based regimens to Lopinavir/ritonavir
Drug: Lopinavir/ritonavir
Lopinavir/ritonavir 400/100 mg twice daily
Other Name: N/P
- Plasmatic HIV-1 Viral load [ Time Frame: week 48 ]
- CD4 cell count [ Time Frame: baseline, weeks 12, 24, 36, 48 ]
- Changes in liver enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma GT, alkaline phosphatase) [ Time Frame: baseline, weeks 12, 24, 36, 48 ]
- Changes in total bilirubin [ Time Frame: baseline, weeks 12, 24, 36, 48 ]
- Changes in lipid parameters (total, HDL-, LDL-, cholesterol, triglycerides) [ Time Frame: baseline, weeks 12, 24, 36, 48 ]
- Administration of lipid-lowering drugs throughout the study (new administrations or the withdrawal of previous lipid-lowering drugs) [ Time Frame: baseline, weeks 4, 12, 24, 36, 48. ]
- Adverse events [ Time Frame: weeks 4, 12, 24, 36, 48. ]
- CSF and genital tract HIV-1 viral load [ Time Frame: baseline, weeks 24, 48 ]
- Plasmatic, CSF and genital tract trough-DRV and LPV concentration [ Time Frame: weeks 12, 24, 48 ]
- Resistance mutations in case of confirmed virological failure (plasmatic, CSF and genital tract) [ Time Frame: baseline, weeks 4, 12, 24, 36, 48. ]
- Neurocognitives changes [ Time Frame: baseline, week 48 ]
- Time to virological failure, defined as an increase in HIV RNA >50 copies in 2 determinations within 1 month. The first date with VL > 50 will be used to calculate time to virological failure. [ Time Frame: weeks 4, 12, 24, 36, 48. ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 65 Years (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- HIV-1 infected adults (=/+18 years old).
Patients having a diagnosis of HIV infection, on stable HAART including:
2 NRTI/NtRTIs plus one of the following : 1 PI/ritonavir (lopinavir/ritonavir, atazanavir/ritonavir, fosamprenavir /ritonavir, tipranavir/ritonavir, darunavir/ritonavir) or ATV/unboosted (in a regimen without tenofovir) 1 NNRTI (nevirapine or efavirenz), raltegravir or maraviroc
- Undetectable plasma HIV-1 RNA (VL < 50 copies/mL) while on HAART during at least 3 month prior to switching.
- Nadir CD4 cell count > 100 cells/mm3.
- Absence of major PI-resistance mutations in HIV-protease (IAS 2008).20 Good treatment adherence.
- Voluntary written informed consent.
- Patients and physician's preference to change the current HAART regimen for reasons of simplification and/or toxicity.
Exclusion Criteria:
- History of virological failure to a previous antiretroviral protease-containing regimens.
- History of virological failure defined as two consecutive plasma HIV-1 RNA > 50 copies/mL while on current antiretroviral therapy
- Acute infections or uncontrolled chronic infection in the 2 months previous to the inclusion or physical examination that, in the investigator's opinion, would compromise the patient's safety or outcome of the study
- Breastfeeding, pregnancy or fertile women willing to be pregnant.
- Patients co-infected with hepatitis B.
- Concomitant use of any drug with potential drug-drug interaction with DRV/r or LPV/r at study entry.
- Therapies including interferon, interleukin-2, cytotoxic chemotherapy or immunosuppressors at study entry.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00994344
|Germans Trias i Pujol Hospital
|Badalona, Barcelona, Spain, 08916
|Hospital Universitario de Canarias
|Santa Cruz de Tenerife, Canarias, Spain, 38320
|Responsible Party:
|Sílvia Gel, Dr. Bonaventura Clotet, Germans Trias i Pujol Hospital
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|October 14, 2009 Key Record Dates
|Last Update Posted:
|February 13, 2014
|Last Verified:
|February 2014
Antiretroviral simplification strategy
Treatment experienced
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
HIV Protease Inhibitors
Protease Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-HIV Agents
Anti-Retroviral Agents
Antiviral Agents
Anti-Infective Agents
Cytochrome P-450 CYP3A Inhibitors
Cytochrome P-450 Enzyme Inhibitors


text:
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In the year 1917, Richard Alfred Hargreaves founded a firm of Chartered Accountants at Lloyd's Chambers, Market Street, in Colne. In 1921 John William Brown and William Benson joined him as partners, and Hargreaves Brown & Benson Chartered Accountants still flourishes today from offices in Bond Street, Colne.
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29 Oct 2020
Chancellor Rishi Sunak will set out a one-year Spending Review on 25 November as the government continues to tackle the economic slump caused by the coronavirus (COVID-19) pandemic.
27 Oct 2020
The JSS Open and JSS Closed are introduced from 1 November 2020.
Following ongoing government advice, we are taking extra precautions to ensure the health and safety of both our employees and clients.
The majority of our staff will now be working remotely; however, they are contactable to help and support you through this difficult period.
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Saturday, October 24, 2020
Israel rejects Palestinian petition to redirect Wall in Cremisan valley
Fatima Masri
- May 29, 2013
Main News
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Beit Jala hospital
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Cremisan Valley
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UNESCO World Heritage Site
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the Wall
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Photos by
Eugene Peress
The Israeli Special Objection Court rejected the latest petition from Palestinian landowners in the town of Beit Jala to redirect the wall that intends to cut off the Cremisan Valley—located in the Bethlehem district—from the surrounding villages of the Jerusalem area. The ruling, rendered official on 26 April 2013, allows for the continuation of the wall's construction as planned according to the two military orders issued in 2011 stating Israel's right to confiscate 37.3 dunams and 15.2 dunams of Cremisan land respectively.
Confiscation of land in the Cremisan Valley falls into the plan —announced by the Israeli Municipality of Jerusalem in 2004 —of building the settlement of Giv'at Yael to fill in the gap between the southern part of Jerusalem and the Gush Etzion settlement block, southwest of Bethlehem, seizing a total of 4,111 dunams of land from the towns of Beit Jala, Battir and al-Walaja. The result will be the creation of a Segregation Zone that disrupts the territorial contiguity of the nearby Palestinian villages and confines their inhabitants into small fractured enclaves.
Severing ties in Al-Walaja
An iron gate has been built on May 8 on al-Walaja's main road, effectively blocking access to the town. The checkpoint at the entrance of the village undermines freedom of movement and access to education and medical care for all of the village's 2,000 plus residents.
The Society for the Preservation of Nature in Israel objected to the barrier in the area of al-Walaja, claiming that construction of the wall will destroy the terrace-cultivation, which has existed for more than 1,500 years.
The community itself will also be affected by the completion of the barrier. This is the case for Abed Abed Rabbo, of Dehaisha refugee camp, whose property will fall under Israeli jurisdiction once the wall is finished. His house is carved in the walls of a cave and fully covered with newspapers articles on his case and pictures of his brother, jailed thirty years ago.
The place is a meeting point where friends and neighbours speak about politics and future plans while enjoying the cool breeze on the porch. This will no longer be possible once the Segregation Zone is completed, as neither friends nor relatives will be allowed to access the area. Abed has been granted a residency permit allowing him to continue living on the property, but his new neighbours will be Israeli settlers. No force has been used against him, in the hope that he will himself decide to move to a more friendly area. However, Abed swears that he will never leave, saying, "For Palestinians, land is not a place where you live in, but a part of our own identity".
Battir's waning hopes for UNESCO recognition
UNESCO's recognition of Battir as a World Heritage site could be the only viable way to put an end to Israeli construction plans in the area. Yet the application, previously scheduled for June, is now on hold. In the UNESCO lexicon, Battir is a transboundary site, as its land falls partly in Israel and partly in the West Bank. Israel issued two major orders of land confiscation in 1981 and in 1983, seizing 900-1,000 dunams of land from the total 12,000 dunam area. If accomplished, the plan for the new wall would annex an other 2,000 dunams of Battir's land. Submitting a request to UNESCO necessitates clear definition of the relevant territories and borders; in the case of Battir, the disagreement on where the line should be drawn is leaving the situation in a legal deadlock. Palestinians have two uneasy options. They may either choose to include the land annexed by Israel in their Wolrd Heritage site application, which would most likely cause a legal dispute transcending UNESCO competence and would probably end in the dismissal of the Palestinian request, or they could comply with the borders drawn by Israel and subsequently diminish any possibilities of future Palestinian claims to the land.
While the villagers of Battir weigh their decision and its potential outcomes, Michal Nasser, of the Battir Landscape Ecomuseum, recently announced the accomplishment of another project, the first guesthouse in Battir. "Its main aim is to share our beautiful landscape with people from all over the world but then of course, it will help raise awareness of what is happening under the occupation."As recognition from UNESCO seems unachievable in the near future, raising awareness is deemed as the only tool of opposition against the Israeli plan in the area.
The Israeli government claims the wall will secure a railway located right in the heart of the town. However, Israel's move to create a wall in the area comes in direct contradiction to the Rhodes Agreements of 1949, which grant Palestinians in the area access to the farmland falling beyond the railway trails, provided no damage to the railway is attempted. The inhabitants of Battir have kept their side of the agreement, however they will be dispossessed of their lands and source of income if the UNESCO recognition falls through. The Israeli government proposed to create an agricultural gate to provide access to cultivated lands, but local farmers fear Israeli soldiers will not completely comply with the measure.
The terraced agriculture land, based on an irrigation system dating back to the Roman period will be irremediably damaged during the construction of the wall, causing a disastrous environmental impact, Michael Nasser explains.
The wall will also separate the monastery of the Salesian Order in al-Walaja from the convent in Battir, where nuns run a school for Palestinian children. Once the barrier is complete, they will have to face a one-and-a-half hour journey instead of the usual twenty minutes to reach the school. The militarization of the area and the increased possibility of clashes will most likely further encourage students to drop out from school.
Legal implications of the wall
The wall sharply deviates from the Green Line, the demarcation line separating Israel and the territories captured in the Six-Day war of 1967. According to B'Tselem, the Israeli Information Center for Human Rights, 85 percent of the wall's route falls outside the Green Line and is illegal according to a landmark advisory opinion of the International Court of Justice.
The Israeli government adduces security reasons for the construction of the wall, despite the fact that no incidents have occurred since 2002. Most of the one-hundred-plus petitions filed to the High Court of Justice and the Special Appeals Committee have been rejected citing the Emergency Land Requisition Law, which allows for Israel's confiscation of private land for public security reasons.
Israel's dismissal of the latest attempt to reroute the wall proves, once again, its disregard for the basic right to nationality and self-determination enshrined within international human rights law, as well as the lack of available legal remedies for Palestinians in the face of continuous violations of their most fundamental rights.
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By Lyz Lenz Beyonce's pregnant belly is everywhere. Mariah Carey won't stop showing off her twins and now Jessica Simpson (finally) announced on Halloween that she's going to be a "mummy." With celebs carting their new babies around like expensive handbags and tabloids touting pregnant bellies as the latest trend, it would seem like pregnancy is as easy as getting dressed for an awards show. It's not. And despite how good Beyonce looks or how skinny Heidi Klum is, pregnancy isn't that pretty either. For those of us without stylists and designer maternity brands begging us to shill their expensive clothes, pregnancy can get dowdy, fussy and downright painful. Even women who loved being pregnant will tell you about the days they didn't put on pants because nothing fit, the shooting pelvic pain that confined them to the couch and their ugliest shoes, the cellulite, the stretch marks and having to wear pads in their undies because there was leaking down there. Ew you say? Well, that's the reality of pregnancy. And it's a reality that I wish celebrities would be honest about. The unrealistic expectations of pregnancy set by celebrities causes women to feel ashamed of the flab, the bulge and budge that are a normal part of having a child. According to New York Magazine, when you combine our celeb-obsessed culture with our cultural struggle with our waistlines you have a problem. "Toss into this roiling mix the Atkins and South Beach diets—the latest devotionals in New York's Church of Divine Diminishment—and you've got a freshly-minted group neurosis. You've also got an unnerving question: Are women starving their babies by starving themselves?" Let's get real. Heidi Klum talks about baby weight just dropping off, and while mine did too (I'm even down 7 pounds from where I was before), the reality is nothing fits right. Jeans sag in places they used to bulge and bulge in places I never had before. Angelina Jolie walks around in a bikini after having twins and, while I don't doubt she can get her stomach back (with the help of a fleet of personal trainers), it's never going to be the same. Pretending otherwise is just false marketing. I was lucky enough not to get stretch marks and my stomach still looks like pockmarked flubber and that's seven months out, one half-marathon and a million sit ups later. A friend of mine who is a personal trainer and ran a marathon three months after giving birth admits that she's got a pile of skin that flops over her size four jeans when she sits down. You don't see Denise Richards pretending marriage is a breeze or Jessica Alba talking about how high school was a cinch, so why, when it comes to pregnancies, do celebrities feel the need to airbrush the stretch marks and deny all knowledge of cankles? Pregnancy is such a personal journey, consisting of a woman, her body and the baby and while other people are involved—family, doctors, spouses—no one knows the intimate uglies of and joys of the experience more than you. And while it may be many things—exciting, scary, elating, downright exhausting—glamorous is not one of them. The best thing Beyonce can do after she gives birth is to let us see her with a post-partum belly that looks like she might be hiding another baby in there. Then, admit that her butt will probably never be the same.About the Author: Lyz Lenz is a writer, a mom and a midwesterner. Although, not in that order. She lives in Iowa and on the web at LyzLenz.com
Why do celebs feel the need to airbrush stretch marks and deny all knowledge of cankles? One mom sounds off.


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Forbes names City of Austin a Top 10 Employer
For the second year in a row Forbes Magazine has put the City of Austin near the top of its list of America's Best Employers. This year, the City of Austin jumped up to the ninth spot. Last year, we were 22nd.
The annual list from Forbes ranks the top 500 employers in both the public and private sectors. For 2017, the City of Austin was the highest ranking employer in the government services sector.
Other companies in the top ten include Costco, Google, REI, MD Anderson Cancer Center, and Wegmans Food Markets. This is the third year Forbes has ranked the top 500 employers.
We are so proud of this recognition because it highlights what I already know about the City. It reflects the tireless dedication of the more than 13,000 employees who make the City of Austin an incredible place to work. It also recognizes our exceptional employees who are truly committed to serving the people of Austin. I continue to be impressed by our staff and am proud to work alongside them every day.
Forbes created the list by working with online statistics provider Statista to survey more than 30,000 workers from companies with more than 5,000 employees.
Employees were contacted anonymously online without the involvement of their employer. Those surveyed represented the U.S. workforce by gender, age, region, education and ethnicity.
To view the full list visit: http://www.forbes.com/best-employers/list/


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Discover for free which first names would suit you or your baby !
Meaning of name Kristian
Etymology : Scandinavian and Finnish form of CHRISTIAN
Saint :
Origin : Scandinavian
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Gender : boy
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Who is he?
He is quite an elusive man, secretive and reserved, often shy and on the defensive. However, this tendency is strongly offset by another that drives him to express himself and communicate, compensating for his lack of self-assurance and worry by an apparently easy-going, and sometimes provocative attitude. In fact, Kristian possesses a somewhat dual nature: a lively and energetic man, cheerful if not carefree and a little unsettled, who loathes constraints and requires action and change in order to fulfil his perpetual craving for discovery and adventure. But then there is the cerebral and tormented man, pessimistic and somewhat solemn, inclined to pose existential questions in his quest for fundamental answers, although he might just learn something, because he possesses a sharp, shrewd and analytical mind (pronounced if he was born on a 7th, 16th, 25th, or has a life Path Number of 7). His scepticism could easily make him appear sarcastic or mocking. He could be tempted to take the path of least resistance, or he may choose to continue his education, but more often than not, he will be looking for action: he seeks autonomy and freedom above all. Kristian is rather disconcerting and could appear to be an "eccentric", or "different", precisely because he chooses not to follow the crowd, and this could occasionally result in his becoming an "outsider". His parents should raise him with a certain amount of rigor, instilling notions such as hard work and discipline: he must learn that the easy way isn´t always the best way. He tends to be unsettled, chaotic, impatient, cantankerous and egotistical. He enjoys physical activity and good old-fashioned fun, and it would be wise to keep a close eye on his school work. Basically, he is an extremely bright and lively child just waiting for the chance to be passionate about his education.
What does he like?
His aspirations lead him to action, sport and adventure, the unknown being particularly attractive to him. If he happens to be drawn to the field of intellectual inquiry he is likely be very fond of ethnology, archaeology, and philosophy, as well as the latest cutting-edge technology or perhaps science fiction... He likes to have a laugh and a lark, and make the most of life´s pleasures. Where his romantic life is concerned, he usually gets the girl thanks to his terribly charming ways... However he often feels misunderstood in a relationship, because concealed underneath his easy-going ways is a modest young man who has difficulty expressing his innermost feelings. Kristian is a sensual Epicurean, athough his favourite food tends to be of an intellectual nature and his most sensitive organ - his brilliant mind.
Get your free Personality test card now !!
What does he do?
Kristian tends to change direction or employment quite often, since he doesn´t like monotony very much. He is likely to be attracted to professions that would allow him to express himself and develop his communication skills, and he could be particularly at ease with a career in commerce, advertising or sales and marketing, in relation to travel, sports or games (sales and marketing, presenter...), oral or written expression (actor, journalist, lawyer, writer, teacher...), creativity or one of the avant-garde or highly specialized professions (architect, computer specialist, plumber, electronics engineer...).
Discover others boys first names : Kraig Krasimir Krastio
*To note: :
It sometimes happens that two different first names have the same meaning. This has nothing surprising: both first names have the same figures of numerology. It is as in astrology: two persons belonging to the same sign present the same characteristic...
Names compatibility
Test the compatibility of your names to know if your love relation is lucky to succeed. Friendship, love or passion?
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Your Name Horoscope !
Thanks to the numerology, we propose you daily a horoscope personalized for your first name. Love, money , Shape: discover what waits for you for today. In Bonus every day find your daily lucky figure .. Horoscope of the first names
Love :Couples: The complicity between the two of you will be reinforced. Singles: An admirer will make themselves known.
Money :You are trying to decide whether or not to make a property investment. Take your time.
Health:You won't see any results without some effort Kristian .
Your Lucky number : 80


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Repositories and data preservation FAQ
Where can I store my data for the long term?
While many funding agencies are requiring that data be shared, they are not providing a mechanism for doing this. Some directorates, like the NSF's Division of Ocean Sciences, recommend specific repositories (pdf), while others do not.
Regardless of whether your funding agency provides specific recommendations, data that is intended to be preserved for the long term should be stored in a repository that offers digital preservation services. The Stanford Digital Repository is such a service. You may also choose to preserve your data in a trusted subject-specific repository (like GenBank or PDB) or with publishers who offer a data deposit service as part of the publishing process.
Please note that the SDR is for use by Stanford researchers only. A valid SUNet ID is required to access our online deposit application.
The use of a standard back-up service is not recommended as a long term data archiving strategy.
What can the Stanford Digital Repository do for me?
The Stanford Digital Repository provides you with 1) secure permanent preservation of your data, 2) an easy access point (persistent URL or PURL with a stanford.edu address) for those who are interested in finding, downloading, and reusing your data -- without all those emails back and forth and digging through old hard drives! -- and 3) peace of mind that you have fulfilled your duties to your funding agency with a minimum amount of fuss.
What data formats can I store in the Stanford Digital Repository?
The Stanford Digital Repository is completely content agnostic. We can take any type of data in any format.
However, another question you may want to ask yourself is "What data formats are best for sharing or best for preservation?" You may also consider how others may want to use your data. Some researchers may want your entire data set, while others may only need subsets. Some researchers will have access to the same proprietary software that you used, while others may not. Thinking about questions like these will help inform your decision making on how exactly you want to preserve your data.
Is there a fee to use the Stanford Digital Repository?
There are currently no fees associated with depositing data into the Stanford Digital Repository using the web-based, self-deposit interface. Larger deposits cannot be completed via this interface and will likely require more work, more storage space, and a fee. We are currently still in the process of working out the fee structure.
Please note that the SDR is for use by Stanford researchers only. A valid SUNet ID is required to access our online deposit application.
How much time and effort does it take to preserve data in the Stanford Digital Repository?
Our web-based self-deposit interface is very easy to use. Once you have organized your files and gathered the basic information about your data deposit (contributors, abstract, citation, related publications and links, brief descriptions of the files), a deposit can literally be done in less than five minutes. The information we ask you to supply with your deposit is important for enabling and supporting the discoverability of your deposited data.
What's the lowdown on the PURLs? How does that work?
A PURL is a persistent URL. It's a web address that is guaranteed to remain stable over time. The PURL contains a persistent identifier called a DRUID (digital resource unique identifier) that functions much like a DOI. You can link to a PURL from anywhere and it will always take the user to that same page. Never worry again about shifting servers or moving to another institution!
My colleague told me I could get a PURL from you. Is that true? How do I go about doing this?
Your colleague is correct! When you deposit data in the Stanford Digital Repository, you will receive a PURL address for that data. If you are interested in depositing data for a PURL, please contact us at email@example.com. We can set you up with access to the web-based self-deposit interface.
Please note that the SDR is for use by Stanford researchers only. A valid SUNet ID is required to access our online deposit application.
Will you come talk to our group about preserving data in the Stanford Digital Repository?
We would love to come talk to your group, anywhere on campus, at any time, about preserving data. Please contact us at firstname.lastname@example.com, and we will schedule a visit to your part of campus!
Should I obtain permission from someone before naming the Stanford Digital Repository in my data management plan?
While this is not absolutely required, we would very much appreciate advanced notice that people intend to use our services. With advanced notice, we can plan ahead for an increase in use in the coming months or years. Also, by talking with us when you are generating your data management plan, we can discuss with you whether the data you are collecting is of a type or quantity that will require special treatment or may incur fees (see the comment above about fees for the Stanford Digital Repository). If your project will incur fees, you may be able to write these costs into your grant.
Please note that the SDR is for use by Stanford researchers only. A valid SUNet ID is required to access our online deposit application.
I have a lot of data and want to do some serious data preservation. Are you up for it?
You bet we are! Please contact us at firstname.lastname@example.com and we'll plan a time at your convenience to talk with you about what you have in mind.


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In Town for the Rose Parade or Rose Bowl Game?
Visitors in town for the parade or big game? Have a friend staying at one of our local hotels? Nixle is a great resource for those living in town or visitors to the area. The two major agencies responsible for Tournament of Roses activity both have Nixle accounts and share valuable safety information with the public. The Pasadena Police Department and the Los Angeles County Sheriff's Department, along with other local police agencies like Arcadia, Burbank, and South Pasadena, all use the Nixle platform for instant messaging.
We would like to encourage everyone, including those visiting the area, to take advantage of these services and subscribe to local public safety before the need arises.
A simple method to subscribe for Nixle alerts regarding the Parade or Rose Bowl is to text "ROSEPARADE" to 888777. For those in Arcadia, text either 91006 or 91007 to 888777 and you will be included in any emergency alerts sent by APD. Check with your host or concierge for the local zip code for your area hotel in neighboring cities to be included in other area alerts.
You can also download our smart phone app for links to other information and services from the Arcadia Police Department.


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LED Channel Systems
Creating a professional LED strip light installation has never been easier. We offer a wide variety of high quality and innovative complete channel systems for LED strip light installations. This wide selection includes our EL Aluminum Channel line and the Klus LED profile systems, both perfect for finishing LED strip light applications. We've organized our Aluminum Channel and Diffusers into compatible systems for easy online ordering. Choose from a wide selection of over 100 complete systems! A complete LED Channel Systems Directory is available for your reference.
From ultra thin to extra wide, as well as specialty extrusions for sconces, closets, stair treads and more, you are sure to find the perfect LED channel system for your project. Accessories, including mounting brackets, end caps and micro-switches are sold separately. Simply choose the type of LED strip light you want, and then select an LED Channel System to fit, or vice versa. We even created a LED Strip to LED Channel Compatibility chart for your reference, so you can choose the best fit for your installation.
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United Kingdom
United States
World English Go to Usborne.com
Usborne Quicklinks
Quicklinks for internet-linked books
Click on the links to visit the recommended websites.
Websites to visit
Website 1
Watch a video clip about castles.
Website 2
A quick guide to castles.
Website 3
Zoom through a reconstruction of a medieval castle.
Website 4
Watch a video clip that explains important castle features.
Website 5
Find out different ways castles were attacked.
Website 6
Watch a video about how to destroy a castle wall.
Website 7
Things to make and do about everyday castle life.
Website 8
Find out about heraldry, design your own coat of arms and make a cardboard shield. (For instructions on making the shield, click on "make your own cardboard shield".)
Website 9
Take part in a tournament and joust online. (This activity uses Flash and may not work on all browsers.)
Website 10
Dress a knight in his suit of armour. (Click on "When the knight is dressed" for a puzzle on the different parts of a suit of armour. NOTE: click the "high quality" toggle to improve the clarity of the image.)
Website 11
Take a video tour of Hampton Court Palace.
Website 12
See inside Windsor Castle, the oldest occupied castle in the world and one of the official residences of Her Majesty The Queen.
Website 13
Watch an actor describe life as a medieval chef, creating the finest desserts for important castle guests.
Website 14
Picture guide to parts of a castle. (Click on a word to see a picture, or click on "Definition of a Castle" to see more castle pictures.)
Children, make sure you follow these three simple rules when using the internet:
For more tips, see Internet safety for children.
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For more on internet safety, see Internet advice for adults.
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See inside
See inside castles
"It would be impossible to praise this series too highly."
Bookseller Back to School June 2007
Katie Daynes has written oodles of books for Usborne, from lifting the flaps on germs and poo, through things to spot in the sea and at school, to the life stories of Nelson Mandela and Marie Antoinette. She wrote My First Chess Book after being taught by her son, Joe Birks, who became the British Under 9 Chess Champion in 2017. She now lives in Yorkshire with her architect husband, two inquisitive children and a hamster called Toffee. When she's not writing books, Katie likes walking on the blustery moors, meeting friends for coffee and playing competitive board games.
The Usborne 'See Inside' series is fantastic and 'See Inside Castles' is no exception. My son is 7, and just learning about castles as his topic at school. This book was a great introduction to castles in history, and it helped him to understand how the structures progressed from wooden structures, to fortified stone castles.
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a daily newsletter full of things to discuss over drinks.and the great thing is that it's on the house!
Blue Mountains News.Net
Blue Mountains News.Net's News Release Publishing Service provides a medium for circulating your organization's news.
© Copyright 1999-2020 Blue Mountains News.Net - Mainstream Media Ltd. All rights reserved.


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Here is some pics of my Raspberry PI Laptop.
It uses a Motorola Lapdock which is a Dumb 11 inch screen, keypad and mouse. It has annoying connectors for docking the Motorola Atrix Android phone but with some custom cables and adapters I can connect my PI.
Next step is smaller HDMI cable and some sort of casing.