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Can You Hear Me Now?
As we approach 24 hours after the bizarre bullpen screw-ups that may have helped to cost the Cardinals Game 5 of the World Series, one question crystallizes out of the haze:
Tony LaRussa expects us to believe that his bullpen was told to get closer Jason Motte and lefty specialist Mark Rzepczynski ready, but heard only "Rzepczynski"? And following that disaster, they were again told to get Motte ready but instead thought they heard "Lance Lynn"? That the noise was so deafening and the bullpen phone so reminiscent of a string-and-juice-can, that they missed the name of the number one guy down there, and then mistook one name for another that doesn't sound anything like it?
And most importantly, after it happened once, nobody double-checked the second time they tried to get Motte warm? No "repeat it for me! Spell it!"? Nobody down there with a sense that in a sport where the bullpen coach was blamed and fired for Bobby Thomson's home run ("Erskine is bouncing his curve," Clyde Sukeforth said in 1951, sending the other pitcher warming, Ralph Branca, to his Dodger doom), that screwing it up once was a fireable offense?
Even if the bullpen staff is – so to speak – off the hook in the responsibility equation: are there no monitors? Are there no coaches who don't think Jason Motte and Lance Lynn aren't the same guy just because they both have beards? Did we really luck out last night because Bruce Sutter didn't find himself warming up? LaRussa and Dave Duncan never noticed the wrong pitcher was throwing? When it was shown on tv? The second time?
If all of these questions are legitimate, there should have been people fired this morning, LaRussa included. My guess is the questions are not – they're too amateurish to be believed of the worst manager in baseball, let alone LaRussa.
And if that's true, it raises two more and far more disturbing questions: why is LaRussa lying and what really happened?
What? You want to know about the Albert Pujols "I called the hit-and-run then chose not to swing" fantasy? Don't get me started. Let's just chalk that one up to extra-terrestrials.
26 Comments
Okay, intervention time. Your LaRussa hangup is getting as bad as the Tea Party's thing about Obama. What is the real issue, seriously? Despite the fact that he managed this team to a historic comeback, he can do no right in your eyes. No credit, but you jump on every perceived fault. Fire him? After that comeback? Are you nuts? This is really…odd. I'll tell you the same thing I say to the teabaggers…seek professional help. Seriously. I'm not kidding.
Here is the problem with LaRussa J.D. He has an excuse for everything that goes wrong. He never accepts responsibility. He talks about how his team plays the game the right way, but then you have a pitcher like Carpenter hurling F-Bombs at Napoli. Pujols not talking to the media after a major mistake that lead to a Rangers win.
He has blamed the Brewers for lights that are distracting, stealing signs, and Brewers pitchers intentionally throwing at Pujols. Even though Ryan Braun was hit the game before. It is one excuse after another for LaRussa. His schtick is old and you get mad at KO for calling LaRussa out?
And it's not LaRussa's managing why the Cards made the playoffs, you can thank the Atlanta Braves for their historic collapse.
Um, the Braves collapse means nothing unless the Cardinals, um, you know…WIN. Which they did. You may not like his methods – hell, even I think Whitey Herzog was a much better manager, overall – but he gets the job done. I wouldn't mind the blame so much, but what bugs me is Keith almost never gives him any credit. And this goes for not just LaRussa, but the Cardinals as a whole. I heard barely a peep out of KO after Game 3, for instance.
As a Cardinal fan for over 25 years, it gets a bit tiresome. The Cardinals have one of the greatest franchises in the history of the sport, with the second most championships of all time, yet all we hear about is the Yankees-Red Sox thing, or what the Cubs are up to, etc. Keith is far from the only culprit here (MLB Network's Rangers-boosterism borders on Fox "News" levels of bias), but we love our team, and we're a little sick of the hate…or should I say, as Yankees fans often do in reference to the hatred of their team…jealousy? 🙂
I would have to ask Keith…is this a political thing? If so, while I agree with his politics 9 times out of 10, I'd have to ask that he stop letting it get in the way of his objectivity. I hate LaRussa's right-wing idiocy as much as KO does, but I don't let that stop me from giving him credit when it's due…and that goes back to Tony's days in Oakland and with the White Sox, so you can't chalk it up to pro-Cardinal sentiment. Results are results, and they show that LaRussa's one of the best managers in the history of the game. Wins don't lie.
Oh c'mon, STL is one of the most hyped teams in MLB. There is a level of respect for Tony LaRussa, in spite of his constant whining and inability to take responsibility for shortcomings, that surpasses baffling. The media long ago ordained him a Very Smart Man and any number of shortcomings will not undo that diagnosis. If you have to deal with some stick, oh well.
You're serious? You think LaRussa and the Cardinals don't get enough credit? The man was anointed a genius decades about by George Will and we've been hearing about it ever since. You've had St. Louis boosters like Costas and Buck dominating the airwaves all that time. Give me a break!
A 25-year fan of the Cardinals has no moral standing calling out a network for bias. Do you realize how silly you sound? "I'm not biased, but those MLB guys sure are!" Please.
All this seems like a non-story to me. The bottom line is the Cardinals bullpen which was so good during their run to the World Series is falling apart. But I wonder if the pitcher could fake an injury on the mound so the right guy could replace him and have all the time he wants to warm up. Any drama in this series would be welcomed anyway because what looked like a potential classic is turning into another ho-hum affair. I tend to be anti-La Russa but I think he's doing a decent job in the World Series. The players need to hit with runners in scoring position, Carpenter needs to bear down and not let the lead slip away, and the bullpen (no matter who is on the mound) needs to get the job done.
MLB rules require that the dugout phone be restricted to specific handsets in the ballpark. Usually the dugout phone goes to the bullpen. Some MLB dugout phones have 2 buttons – to dial the bullpen or the press box.
Seriously. One last time. I've tried. WharfNYC.com. I'll be there about 10 tonight and stay to the point where my my coach turns into a pumpkin or I go home. MLB is playing there it says.
I guess he is afraid to lose and get the blame
Sam makes a good point, it's the players who make the manager look good or bad. LaRussa made the same moves against the Brewers and they all worked.
Good points J.D. Being a Brewers fan I thought MLB Network was pro-Cards most of the time. Personally, I thought they have been pretty fair both ways during the World Series. Cards deserved where they are at, they were the hottest team at the end of the year, but while they won it did take a big collapse on the Braves part. Personally, I was rooting for the Brewers to face the Phillies in the Championship series. Cards got hot at the right time and would not be surprised if they win the next 2. The one big mistake I think LaRussa made in the Series was taking Motte out after facing just 2 batters. No other manager in the bigs would have made that move. In game 5 of NLDS, Axford did the same thing in the 9th, but was able to get out of it with only 1 run and then the Brewers won in the 10th on Morgan's hit. Gotta stick with your closer, who has been lights out, in that situation.
@JD – as a non-East Coaster, come on, it's totally legit for KO to ask these questions about last night. Washington has been "unconventional" as well but in terms of the pitching changes and the 2 Craig CS, LaRussa had a Grady Little game last night. If he was managing for a franchise that didn't already have some pennants flying (as Little was in 2003 for Boston or, for that matter, any Cub manager), there would be an even bigger uproar.
This isn't East Coast media bias, all of the usual non-aligned baseball bloggers (who equally decry the NY-BOS bias of the networks) are all over this today. LaRussa didn't lose the game last night, but he did put a lot of extra guys on base and give up a lot of outs. That doesn't help.
My issue wasn't with the questioning, which I agree is legit in this instance, but rather KO's repeated pattern of LaRussa bashing.
It was the firing comment where he went over the line, in my opinion. Up until then, I had less of an issue with this particular commentary, and even agreed with parts of it. But firing? Come on, geez. That's where his bias started to show. While the "seek help" comment was over the top on my part, I stand by the rest of my statements.
I agree the Godfathers lyin. My thought is he may be taking heat off Cardinal failure of batters in general or more likely Albert's failure to hit and calling for those disastrous hit and runs. TLR is incredibly (understandably) protective of AP.
LaRussa is protective of Pujols because he needs him to stay otherwise he's Phil Jackson minus MJ.
In Japan they have flat-screen TVs of the bullpen in the dugout so the manager can SEE who's warming up down there. That might have come in handy in this case.
Don't you mean "Are there no coaches who don't think Jason Motte and Lance Lynn ARE the same guy just because they both have beards?"?…Yeah, I know. Long day…
I can think of several reasons to dislike LaRussa:
1. He's a micromanager, who is as responsible as anyone for the use of 78 relief pitchers in every game. If a pitcher can't face more than one batter, he has no business being a Major League pitcher IMHO.
2. His turning a blind eye to steroid use while at Oakland and then with St. Louis. I know he isn't the only guilty party for this chapter of baseball history, but if there was any justice MLB would have stripped the 1989 World Series championship from the A's.
3. He has a law degree, which makes him a trained liar.
I wouldn't be too sure about KO rooting for the Rangers. After all, his "good and dear friend" George W Bush has been front and center as the Rangers' biggest fan again during the World Series.
This is all really quite simple. LaRussa screwed up and is throwing others under the bus. This is the second game in this series that was decided by manager's decisions and Ron Wash kicked his ass BOTH TIMES! Wash kicked LaRussas ass, Napoli kicked what ever pitcher's ass & the Rangers kicked the Cards ass. Stop making excuses
We won, little man. Up yours. 🙂
In short: LaRussa is the most overrated manager in baseball. I thought this even when he was in Oakland. The fact that he's managing a team in the Series and won't even take responsibility for his own decisions — or at least say "the buck stops here" I just find sad.
He's got a terrible dye job, too.
Very few GREAT managers throw either their players or their coaches under the bus. LaRussa seems to want to be anointed a genius, but refuses to accept responsibility when he screws up. In that he appears to be a typical right-wing crybaby — DEMANDING "personal responsibility" of others, while blaming others for his mistakes.
His entire "We play the game the right way" schtick is getting tired.
Of course, Washington's, "I just put them out there — he's THE manager – I just want my boys to play" stuff also gets very tired.
As we all know, "It's one game at a time", and we all "put our pants on one leg at a time". Remember, "anyone can win a short series", and "you can never tell how one play can turn a game".
etc., etc., etc., etc., blah, blah, blah.
I was 12 in 1951 and loved The New York Giants. 1954 was pretty neat too.
In other words, I've been listening to this stuff for a long time.
the cards werent even supposed to get to the post season….let alone get passed the phils, then the crue and get to the ws
so tony made a mistake
so he doesnt want to admit a mistake
big whoop
Okay, they need to start using that echo system employed at Occupy Wall Street. LaRussa hollers it to the bullpen. The bullpen hollers it to the stadium. The stadium hollers it to the dugout. The dugout hollers it back to LaRussa. Checking. Mic check. One two. Is this on? Tap. Tap. Mr. LaRussa looks a little too much like Charlie Sheen these days. I am not kidding. I think that IS Sheen dressed up in a Cardinals' costume, going bat-or-beating as a major league baseball manager. The only catch is, he is not saying "WINNING!" (He did drink a little Tiger's blood.) This year they are giving out lots of bubble gum and sunflower seeds! But it looks like something TRICKY is going on. I don't want to say something is rotten in Denmark…ahm…I mean Arlington…even though these games feature The Bush Bunch in all the background shots…and the former potus is throwing out the first ball and all. I agree that this does not add up. Someone has been dressed up as Pujols, too, lately. The guy looked just like him, but obviously is not him. The real one tied with Babe and Reggie…who both got their own candy bars! Where did this new guy get that costume? Now, it is back to BUSCH stadium…Oh Lordy…there is that name again! This time associated with the sauce. What to do? Come in at number two, I reckon! And all this while my local channels on DISH are NOT AVAILABLE! I am having to call the old man down the street to get the scores during the last game! It is a damn conspiracy or something! The DISH man will be here FRIDAY! So, you know what that means! Soup cans and string, like you suggested, Keith. You are right about space aliens, too! ET, forget about phoning home! Phone the damn bullpen!


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(video/audio)Noam Chomsky: Obama's Stance on Gaza Crisis "Approximately the Bush Position"
In a visit to the State Department Thursday, President Obama made his first substantive comments on the Middle East conflict since Israel's attack on Gaza. Obama first mentioned his commitment to Israel's security, without affirming his commitment to Palestinian security. He condemned Palestinian rocket attacks on southern Israeli towns, but didn't criticize the U.S.-backed Israeli bombings of densely-populated Gaza. But in a departure from the Bush administration, Obama acknowledged Palestinian suffering and said Gaza's borders should be opened to aid. We speak with MIT professor, Noam Chomsky.
Democracy Now! Broadcast January 23, 2009
Real Player streaming video or audio plus MP3 download option at this link: http://www.informationclearinghouse.info/article21822.htm


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Enter Creon, with two attendants.
[162] My fellow citizens! First, the gods, after tossing the fate of our city on wild waves, have once more righted it. Second, I have ordered you through my messengers to come here [165] apart from all the rest, because I knew, first of all, how constant was your reverence for the power of the throne of Laius; how, again, you were reverent, when Oedipus was guiding our city; and lastly, how, when he was dead, you still maintained loyal thoughts towards his children. [170] Since, then, these latter have fallen in one day by a twofold doom—each striking, each struck, both with the stain of a brother's murder—I now possess all the power and the throne according to my kinship with the dead. [175] Now, it is impossible to know fully any man's character, will, or judgment, until he has been proved by the test of rule and law-giving. For if anyone who directs the entire city does not cling to the best and wisest plans, [180] but because of some fear keeps his lips locked, then, in my judgment, he is and has long been the most cowardly traitor. And if any man thinks a friend more important than his fatherland, that man, I say, is of no account. Zeus, god who sees all things always, be my witness— [185] I would not be silent if I saw ruin, instead of safety, marching upon the citizens. Nor would I ever make a man who is hostile to my country a friend to myself, because I know this, that our country is the ship that bears us safe, and that only when [190] we sail her on a straight course can we make true friends. Such are the rules by which I strengthen this city. Akin to these is the edict which I have now published to the citizenry concerning the sons of Oedipus: Eteocles, who fell fighting [195] in behalf of our city and who excelled all in battle, they shall entomb and heap up every sacred offering that descends to the noblest of the dead below. But as for his brother, Polyneices, I mean, who on his return from exile wanted to burn to the ground [200] the city of his fathers and his race's gods, and wanted to feed on kindred blood and lead the remnant into slavery—it has been proclaimed to the city that no one shall give him funeral honors or lamentation, [205] but all must leave him unburied and a sight of shame, with his body there for birds and dogs to eat. This is my will, and never will I allow the traitor to stand in honor before the just. But whoever has good will to Thebes, [210] he shall be honored by me in death as in life.
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Let's say you're creating a blogging application that will be home to your vast collection of blog posts. There is a good chance that you do not want all of your blog posts to appear on one single page when someone visits your blog. An obvious solution would be to only display a small number of blog posts on the screen at a time, and allow the user to browse through the different pages, much like your favorite search engine shows you the result of your search query. Zend_Paginator is designed to help you achieve the goal of dividing collections of data in smaller, more manageable sets more easily, with more consistency, and with less duplicate code.
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Make sure you prosper the inner region of Montana because there are many new exciting and awesome adventures awaiting! Sign up for as much activities through the school as much as possible.
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Curious about something that isn't answered here? Feel free to ask Rocky Mountain College a question
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Rocky Mountain College is a small Liberal Arts College Located in Billings, Montana. I was drawn to it because of the small student body, and the low ratio of students to faculty, and for the most part, that is what I found here at Rocky. The faculty are more than fair when grading, and are always willing to talk with you whenever you need help, if time permits. A member of faculty in the field I want to study is actually my academic adviser.Read More
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The San Francisco Chronicle's Joe Garofoli spoke with Sally Ride's family and friends about how the first American woman astronaut — and, now, the first known LGBT astronaut — was a private person who wasn't in the closet as much as disinterested in making a public statement about her sexuality.
"Sally had a very fundamental sense of privacy - it was just her nature - because we're Norwegians, through and through," said her sister, Karen "Bear" Ride, who added that no one knew she had cancer, either.
But since the U.S. still doesn't recognize same-sex relationships — meaning Ride's partner of 27 years, Tam O'Shaughnessy, can't receive federal benefits — her posthumous coming out is much appreciated by LGBTQ advocates around the country. "It reinforces for all Americans that LGBT people are everywhere. We come from every walk of life," said Kate Kendell, executive director of the National Center for Lesbian Rights in San Francisco.
Sally Ride 'never hid,' just private [SF Chronicle]


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Any tips changing the fuel filter on a 2003 K1200GT? Need to get all my parts and tools gathered.
I want to pull the tank and remove the entire fuel unit from the bottom/side. Easier to inspect and change fuel lines and screen, is my thought. Somehow rinse out the tank of there is any dirt or silt inside. Should be an experience.
What parts are required other than the filter. Big enclosure gasket? Several new clamps, fuel tubing, pre filter sock? Napa is $8 and BMW is $43 for the filter. Seems rather high price for a filter.
Another video shows going thru the top and swap out the fuel filter using small hands. Sounds nice for second time I do this chore. First time, I want to see the screen and clean out tanks. No clue what the condition is today.
I see the Air filter 13711464916 is also rather hight priced $43. I will look for a generic one for the Air filter.
Pirates Lair, Boneyardbmw, and MaxBMWmotorcycles are my usual hunting grounds, other than Napa.
Thanks for tips.
Fuel filter 16142325859
Air filter 13711464916


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A Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin in the Treatment of Plague in Humans
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01243437
Recruitment Status : Unknown
Verified September 2012 by Centers for Disease Control and Prevention.
Recruitment status was: Recruiting
First Posted : November 18, 2010
Last Update Posted : September 11, 2012
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
Plague is a severe, life-threatening disease. Plague occurs in focal locations worldwide, but over 95% of human cases reported to WHO are by countries in Africa. The most common clinical manifestations of human infection are bubonic, septicemic, and pneumonic plague. Untreated pneumonic or septicemic plague is fatal in over 90% of cases; untreated bubonic plague is fatal in over 50% of cases. Delayed and ineffectual treatment is a main contributor to elevated case fatality rates, which can be as high as 40%, and to the development of pneumonic plague and plague outbreaks.
Streptomycin is considered the treatment of choice, and prompt administration can reduce mortality to 5% or less. However, streptomycin may cause irreversible hearing loss and vestibular damage, reversible renal damage, and it is contraindicated during pregnancy. Tetracyclines, including doxycycline, are considered effective alternatives but they are bacteriostatic and relatively contraindicated for use in children aged < 8 years and pregnant women.
Ciprofloxacin is a relatively newer antimicrobial that is used extensively in clinical practice because of its broad-spectrum antimicrobial activity, excellent tissue and intracellular penetration, suitability for oral administration, and good overall tolerability. In vitro and animal studies suggest equivalent or greater activity of ciprofloxacin against Yersinia pestis when compared with streptomycin or tetracyclines. However, the efficacy of ciprofloxacin for the treatment of human plague has never been demonstrated, nor is it FDA approved for this indication.
Since 2004, CDC has collaborated with the Uganda Ministry of Health (MoH) and the Uganda Virus Research Institute (UVRI) to enhance surveillance, diagnosis, and ecological control of plague in Arua and Nebbi Districts. Through these efforts, we have collected data on over 2,400 cases of clinically diagnosed plague occurring from 1999 through 2009. In 2008, UVRI and CDC staff investigated 163 suspect plague cases: 57 (35%) had laboratory-confirmed plague illness, of which 14 patients (25%) died.
Because plague is a relatively rare disease that mainly affects people living in rural, impoverished areas, it receives limited attention for research and development of affordable and sustainable diagnostic and treatment options. However, because plague cannot be eradicated, and because it causes high case fatality and has the potential for widespread person to person transmission, continued research should not be neglected.
The objective of this clinical trial is to conduct a randomized, open-labeled, non-inferiority study comparing the safety and efficacy of ciprofloxacin to doxycycline, the national treatment standard in Uganda for plague, in patients aged > 8 years. The primary outcome for this trial will be patient outcome 14 days from enrollment and initiation of treatment. Patient outcome will be evaluated only for those patients with laboratory-confirmed plague illness.
Information gathered from this proposed study will help optimize management of naturally occurring plague in humans in many countries of the world, including Uganda and the United States, by providing clinicians with more choices for optimal antimicrobial treatment. This is particularly true in resource limited rural regions such as Uganda where intravenous or intramuscular injections are less available. Ciprofloxacin currently is being used in Uganda and other plague endemic areas of the world for treatment of other infectious conditions, including infectious diarrhea and lower respiratory infections. In Uganda, ciprofloxacin is widely available in health facilities and local drug shops, and is affordable.
|Condition or disease
|Drug: ciprofloxacin Drug: doxyxcycline
|Phase 2
|Study Type :
|Interventional (Clinical Trial)
|Estimated Enrollment :
|200 participants
|Intervention Model:
|Parallel Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Randomized, Non-inferiority, Active Controlled Clinical Trial to Evaluate the Safety and Efficacy of Ciprofloxacin Versus Doxycycline in the Treatment of Plague in Humans
|Study Start Date :
|December 2010
|Estimated Primary Completion Date :
|June 2013
|Experimental: ciprofloxacin
Drug: ciprofloxacin
|Active Comparator: doxycycline
Drug: doxyxcycline
- all cause mortality [ Time Frame: 14 days ]
- time to defervesence [ Time Frame: days to weeks ]
- antimicrobial associated adverse events [ Time Frame: days to weeks ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|8 Years and older (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Suspect cases of plague will be eligible and will be asked to give consent for study enrollment using the following criteria:
- any person, including women and persons who are minorities, who;
- must be aged 8 years or older, and;
- must have had potential exposure to rodents and/or fleas or contact with a confirmed plague case, and;
- must have a fever of at least 38ºC that developed rapidly, and have at least one of the following:
- One or more buboes, defined as a tender lymph node swelling > 1cm in diameter, or;
- Clinical suspicion of pneumonic plague (e.g. prostration, cough, increased respiratory rate, hemoptysis and/or purulent sputum), or
- Clinical suspicion of cutaneous plague (lesion)
- Clinical suspicion of plague and epidemiologic link with other cases
Exclusion Criteria:
- Patients with suspected plague illness will be considered ineligible for the study and will be excluded from study enrollment using the following criteria:
- Any women who is pregnant, or;
- Any woman who is breast-feeding, or;
- Any person aged < 8 years of age, or;
- Any patient with:
- signs of plague meningitis
- hypotension unresponsive to fluid therapy
- an illness severity score of > 16 at time of enrollment (see below)
- known allergy to ciprofloxacin or doxycycline
- taken tetracyclines, quinolones, gentamicin, streptomycin, trimethoprim-sulfamethoxazole, or chloramphenicol in the 24 hours preceding study enrollment
Patients who are pregnant, breast-feeding, or aged < 8 years will be excluded because doxycycline has a relative contraindication for use in these populations due to drug deposition in calcifying areas of bones and teeth, enamel hypoplasia, and decreased linear skeletal growth rate. [22, 23] Please see section 10.2 for additional background describing the reasoning to exclude patients from these populations. Please see section 3.5 for the specifics regarding the timing of urine pregnancy testing.
The illness severity score is a composite measure adapted from the APACHE-II and Glasgow Coma scores that estimates the severity of a patient's illness at enrollment. Because most clinic locations are remote with little or no laboratory capacity, the illness severity score utilizes only non-biochemical parameters.
Patients will not be tested for Human Immunodeficiency Virus (HIV), and known or suspected HIV-positive patients will not be excluded.
Because this study will be conducted in a remote region of Uganda where no prisons are located, the enrollment of prisoners is not applicable to our study. If for some unforeseen reason a prisoner presents to a study clinic location for treatment of suspected plague, the prisoner will be excluded from the trial.
All study resources will be available and treatment following the UMOH national plague treatment guidelines will be offered to patients with suspected plague at the UMOH collaborating clinics who are not eligible for enrollment or who declined to consent.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01243437
|Contact: Kevin S. Griffith, MD, MPH
|970-221-6400 ext 4259
|Contact: Paul S. Mead, MD, MPH
|970-221-6400 ext 6474
|Uganda Ministry of Health: selected Arua and Nebbi district health centres
|Arua and Nebbi district, Uganda
|Contact: Kevin S. Griffith, MD, MPH 970-221-6400 ext 4259 firstname.lastname@example.com
|Contact: Paul S Mead, MD, MPH 970-221-6400 ext 6474 firstname.lastname@example.com
|Principal Investigator:
|Kevin S. Griffith, MD, MPH
|Centers for Disease Control and Prevention
|Principal Investigator:
|Edward Mbidde, MD
|MRC/UVRI Uganda Research Unit on Aids
|Principal Investigator:
|Issa Makumbi, MD
|Ministry of Health, Uganda
|Responsible Party:
|Centers for Disease Control and Prevention
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|November 18, 2010 Key Record Dates
|Last Update Posted:
|September 11, 2012
|Last Verified:
|September 2012
plague, ciprofloxacin
Yersinia Infections
Enterobacteriaceae Infections
Gram-Negative Bacterial Infections
Bacterial Infections
Anti-Bacterial Agents
Anti-Infective Agents
Topoisomerase II Inhibitors
Topoisomerase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Cytochrome P-450 CYP1A2 Inhibitors
Cytochrome P-450 Enzyme Inhibitors


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May 5, 2013
Strong blasts hit the outskirts of Syria's capital early on Sunday, with reports saying that they were results of Israeli airstrikes on a military research center and Damascus Airport. Israel is thought to have carried out a similar attack days ago.
Syrian TV accused Israel of the attack and of being in alignment with rebel forces.
"The new Israeli attack is an attempt to raise the morale of the terrorist groups which have been reeling from strikes by our noble army," the report said.
The notion was backed by Syrian Deputy Foreign Minister Faisal Mekdad, who said the attack proved that there is an alliance between Israel and Islamists trying to topple the Syrian government. In an interview with CNN he said the airstrikes are a "declaration of war" by Israel and that Syria would retaliate in its own time and way.
Massive explosions have been heard near Mount Qasioun in Damascus. The area hosts the Jamraya military research center, which came under Israeli attack earlier in January and marked the first incursion by Israel into Syrian airspace in six years.
A senior US official confirmed to NBC News that Israeli Air Force bombed the military research center.
The overnight Israeli strike reportedly targeted Iranian-supplied missiles to Lebanese guerrilla group Hezbollah, a Western intelligence source told Reuters. "In last night's attack, as in the previous one, what was attacked were stores of Fateh-110 missiles that were in transit from Iran to Hezbollah," the source said.
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Whether you prefer to meet a holy monkey, eat sushi for breakfast, receive a monk's blessing, helicopter over the Himalayas, or just enjoy the myriad unique views—we've rounded up 50 things that you need to do, eat, see, shop for, and experience in the wide world of Asia.
Experience one of the oldest—and newest—cultures on the Asian continent
Sri Lanka's recorded history dates back to the sixth century B.C. The decades-long war between the majority Sinhalese and the Tamils, the largest single ethnic minority here, ceased in 2009. And now, just under a decade later, the country is poised for a rediscovery: very old Asia made new again.
Drive into Sri Lanka's Cultural Triangle
If you find yourself in seaside Colombo, take five hours to drive inland to Polonnaruwa, one of the country's eight UNESCO World Heritage sites. Construction of the 1,200-square-mile capital began in the 11th century; it was once a sprawling fortified city and the second seat of Sri Lanka's royal dynasty. Explore the ruins of the palace and the carved Buddhas of Gal Vihara.
Face the Lion's Rock
The ancient royal compound of Sigiriya, or Lion's Rock—the star attraction in Sri Lanka's Cultural Triangle—is best visited in the morning, before the day heats up: It takes roughly 45 minutes to reach the summit, but you'll be treated to frescoes, rock gardens, and other splendid sights with every step.
Feel the awe of history in the Buddhist cave temples of Dambulla
There are about 80 caves in this first century B.C. complex that was once inhabited by monks and hermits. Ignore the god-awful Buddha-goes-to-Vegas museum and facade, and instead take the 15-minute climb to the temples. Stop along the way to buy an offering of fresh white lotus blossoms. The first temple you'll see is also the oldest, and is dominated by a 46-foot-long statue—carved directly from the granite mountainside—of a dying Buddha, one of the traditional poses in which he is depicted. The space is so small, and the Buddha so large, that the encounter is unexpectedly intimate: No matter how silent the other visitors are, you can't help but feel the crush of millennia.
Stand in awe of the Taj Mahal
The Taj Mahal is one of the most-visited tourist sites in all of India. To see the temple before the mobs arrive, be on-site by daybreak.
Purify yourself in the Ganges
Varanasi is the Hindu holy city, and to bathe in the Ganges here, even just ceremonially, is to purify yourself.
Salute the sun at Bhangarh
You can visit Bhangarh—an ancient town near Jaipur—as a day trip from Amanbagh, and join the thinning crowds for a session of sunset yoga. It may be touted as one of the most haunted places in India, but we'd rather call it spiritual.
Shop Jaipur's Gem Palace
Fancy an emerald-and-diamond necklace? Even if you can't find something within the Gem Palace's troves, they will custom-make almost anything you dream up—and turnaround can be as fast as 24 hours.
Visit the palace of India's last maharaja
At the heart of Jaipur's old city is the City Palace, which is a complex of mini-palaces arranged as a series of unfolding boxes—so the deeper the realm, the more private and less accessible it becomes. The palace today is mostly under the control of the last maharaja's daughter, Princess Diya Kumari. Despite the fact that the princess and her family still live in the palace, it serves very much as a public living room—you'll see locals chatting in its squares and relaxing in its open-air pavilions—and isn't at all forbidding.
Be stunned by a stupa
Boudhanath Stupa is one of Nepal's largest and holiest stupas. It's most impressive in the evening or at daybreak, when it becomes crowded with circumambulating pilgrims.
Fly over the Himalayas at sunrise
In her Grand Tour of Asia, former editor-at-large Hanya Yanagihara signed up for a flight with Tashi Tenzing Sherpa, the grandson of Tenzing Norgay Sherpa, who summited Mount Everest with Edmund Hillary in 1953. Book a tour similar to hers, through Geographic Expeditions.
Meet a holy monkey
Swayambhunath Stupa is a fifth-century temple complex, also known as the "Monkey Temple" for the holy primates that are said to live on its grounds. (Alas, the complex is also full of monkeys of the less-holy ilk, all of whom are on the prowl for food and alarmingly fearless.) Swayambhunath is as fascinating as it is picturesque, with sweeping views over Kathmandu Valley. If the small monastery on the top floor is open, ask your guide to take you in to light five candles and to wish good fortune for someone else as you do so. You'll be barefoot, of course, so take extra caution when walking on the floors—they will be greasy with ghee, especially near the candles.
Pay the fee to visit Bhutan
Bhutan is rare among Asian countries in that it decided to forgo large numbers of tourists in favor of high-paying ones. Visitors must pay a fairly steep tariff—between $200 and $250 a day, depending on the month—which has discouraged swells of backpackers and gap-year wanderers (it also explains why the average age of touristshere is 56-65). As a visitor, it's easy to get too carried away by the romance of this plan, as smart as it is. The fact remains that Bhutan is a very poor country, and that the government's resolve is being sorely tested: Tourism provides jobs, and convincing people that they'll applaud their own prudence 20 years from now is a hard sell. But still, the plan speaks for itself—you're not likely to see such pristine countryside anywhere else on your tour of Asia.
Drive through the countryside
What you'll notice first about Bhutan is its splendid beauty and the remarkable lack of development. The countryside unfolds as a series of lush pleats of green. The hillsides (the country is largely mountainous) are thick with spruce and blue fir, and wild magnolia trees and rhododendron bushes that have grown to treelike proportions punctuate the roadway. The second thing you'll notice is the emptiness. Cars purr down roads briskly, and there's no honking. Indeed, the roads are so quiet you can hear the breeze and birdsong as you go. By the way, the tales of Bhutan's harrowing roads are overblown: Yes, they're narrow and twisty and full of corkscrews, but only the most anxious will feel unsafe.
Learn where Buddhism and government mix at Punakha Dzong
When the dzong's founding monk arrived here, he brought with him a sacred relic from Tibet, and the compound was attacked three times by the Tibetans who were eager to reclaim the relic. This particular dzong (a type of fortress found mainly here and in Tibet) served as Bhutan's capitol until the 1960s, and still has special significance: The first king was crowned here in 1907, and all the kings since have been married here, including Jigme Khesar in 2011. The first national assembly also met here. Today, the dzong may no longer be the seat of government, but it is still the administrative headquarters of the central Buddhist body, as well as the dzong of the Punakha district (each of Bhutan's 20 districts has its own dzong).
Light a yak-butter candle for fertility at Chimi Lhakhang
The monastery of Chimi Lhakhang, built in 1499, commemorates a sort of bad boy of Buddhism—saint Drukpa Kunley—who came from Tibet and won over the Bhutanese by skillfully conquering a number of pesky demons (Kunley's other interests included drinking, partying, and womanizing). Along the way, he also acquired a reputation for blessing women with children, and so on the way up, you'll see that the houses in the surrounding village are painted with huge phalluses, and in the temple itself, you'll find families with squirming babies and kids, back to thank Kunley for his beneficence. You too can light the traditional five yak-butter candles, after which the monk will pour into your palms a splash of saffron-scented holy water. Take a sip (or at least hold it up to your mouth), and then rub it into your head and throat. Outside, you'll circle the bodhi tree clockwise, as you always do around Buddhist sites, whether you're circling a stupa, a temple, a prayer wheel, or a tree.
Brave the climb to the Tiger's Nest
Taktsang Palphug, commonly known as Tiger's Nest, is a 17th-century structure clinging to a mountainside a dizzying 10,200 feet above Paro Valley. Why the name Tiger's Nest? Because it's said that in the eighth century, Guru Rinpoche flew to this exact spot on the back of a tiger. The initial part of the temple was constructed in the 1400s, although the expansions that give the complex the shape we see today weren't done until the late 1600s. In 1998, a fire swept through the buildings, but the temples were restored to their original shape. There are 15 temples in Tiger's Nest, and all are beautiful, their wall paintings restored by UNESCO.
Try something spicy and something sour in Burma
Much of Yangon life is lived in the streets—culinary life being no exception. You'll see varieties of chilies and limes here that you won't be able to identify, and sample hot bowls of soup like mohinga (a rice noodle and fish soup) or Rakhine mone-ti (a clear fish noodle soup).
Behold Bagan
The 20-square-mile Bagan (formerly Pagan) is one of the most impressive Buddhist temple complexes in Asia. The seat of the first Myanmar dynasty in the 11th Century, it once contained 7,000 monuments, temples, and shrines within its borders. (Today, somewhere around 2,200 remain.) The gold-topped Shwezigon stupa, which was built in 1050, is the prototypical Burmese pagoda. All of them from this period onward have seven tiers (the bell-shaped stupa itself is the sixth tier), which is meant to echo the seven concentric rings around Sumeru, the mythical Buddhist holy mountain.
Pay homage to "The Lady"
Yangon is a mix of old ghosts and new hopes. Along the old colonial buildings, you may stumble upon vendors selling posters bearing the image of Aung San Suu Kyi (aka "The Lady"), for years the thorn in the Burmese junta's side and now a member of Parliament.
Sail Halong Bay
Halong Bay is a 580-square-mile natural cove containing some 2,000 limestone islands, all occupied only by trees, ferns, birds, and monkeys. It is these peaks—some of them cragged and hewn by years of erosion into fantastic shapes—that have inspired centuries of Vietnamese poetry and paintings.
Experience Hanoi's Old Quarter
Hanoi's bustling Old Quarter buzzes with activity all day long. Come early to browse the food markets in peace, then drive a few minutes south to Bun Cha Huong Lien, the noodle shop where Anthony Bourdain and Barack Obama once famously shared a meal.
Feel like you're back at school…in the 11th century
The 11th-century Temple of Literature (located in Hanoi) is Vietnam's first university and a fascinating glimpse into how deep the country's ties are with China: The temple is a series of five courtyards arranged in the classic Confucian style. Today, Vietnam's most-practiced religion is Buddhism, specifically Mahayana Buddhism, which is found mainly in China and Japan. In China, this form of Buddhism was coupled with Confucianism and Taoism (as it is here); as you'll see, despite the magnificent, highly lacquered red temple sanctuary, its decoration is of an altogether more sober (or at least more formal) sort.
Revel in the café culture of Hanoi
As you drive through the streets, you'll see all the little tableaux that, in between the omnipresent neon-lit shops selling cheap clothes and cell phones, make Hanoi the place it is: dozens of pho stands, with their big cauldrons of simmering broth; vendors selling mountains of fruit; bicyclists pedaling by with basketfuls of fresh-baked bread; and, especially, those little street restaurants with their low tables and domino-shaped stools on which men while away the afternoon, eating, smoking, and chatting. This casual café culture can, of course, be partly attributed to the French influence, but it's not all their doing: Hanoi is an ancient city and the seat of Vietnam's university, court culture, and poetry. There is a very long tradition here of sitting around with some tea and gabbing, quoting lines of poetry, and arguing politics.
Walk through Vietnam's cultural history at the Museum of Ethnology
Unlike some other countries in Asia, Vietnam is notably accepting—even encouraging—of its 53 minority groups, as witness by Hanoi's Museum of Ethnology. Some of this is practical, and some of this is strategic. First, the great majority of these groups live in Vietnam's north, on the border with China, and are therefore best not antagonized with such a powerful neighbor. Second, they're a great tourism draw. Many of the costumes on exhibit at the Museum of Ethnology aren't from a hundred years ago; some could well be from last week. The durability of these tribes' signature presentations is astonishing in an age of jeans and T-shirts.
Discover a lost city
The lost city of Angkor Thom is now part of Angkor Archaeological Park (yes, where famous Angkor Wat is located). Built in the late 12th century, it was the final capital of the Khmer empire. Visit the Bayon temple between 11 a.m. and 1 p.m., when the crowds will have gone back to their hotels for lunch (the sun can be intense, though).
Do Angkor Wat right
First rule: Forget sunrise at the Angkor Wat complex. It is so popular now that it'll be more crowded at 5:30 or 6 a.m. than at 7, when those sun-risers are on their way back to their hotels for breakfast. Instead, opt for less-frequented temples such as Beng Mealea (pictured). In the morning, most visitors beat a path to Ta Prohm—known as the "Tomb Raider" temple for its cameo in the 2001 film of the same name. Swing by at around 4:45 p.m. and you'll have it almost to yourself.
Bathe an elephant
Make a splash at the Four Seasons Tented Camp Golden Triangle in Chiang Rai, where you won't just get to walk with elephants—you'll bathe with them, too.
Give an offering to a monk at Wat Sri Soda
Each country in Asia has its own relationship to religion, of course, but it's fair to say that the Thai relationship to Buddhism is unusually vivid. Even Thai men who aren't active-duty monks try, in small ways, to "make merit" for themselves. At Wat Sri Soda, as across the region, this quest can manifest in spectacular ways—remember Jayavarman VII and his prolific temple-building?—but it is often done in a more quiet, quotidian fashion, such as donating an offering of food to one's local temple. Bring (or ask your guide to bring) a packet of food for you to give to one of the monks, who will receive it with a chant. As you descend the hill after spending an hour so exploring the temple, you'll see a chain of young monks walking along with their begging bowls, accepting food from the penitent locals who line the streets early in the morning to receive a blessing. It's a sight both timeless and touching, a reminder—despite the motorbikes and hotels—of this area's unshakable belief and age-old rituals.
Watch the sunset from Chiang Mai's holiest shrine
Take the 30-minute drive outside Chiang Mai to the 14th-century Wat Phra That, Chiang Mai's holiest shrine, which overlooks the city atop Suthep Mountain. Take the 304-step staircase and note the lovely nagas (dragon-headed serpents) that flank the steps: Like so much Buddhist iconography, their origins are Hindu, but in Southeast Asia they are often shown as the Buddha's protector, guarding either him or the temples. At the summit—blissfully empty and a few degrees cooler in the late afternoon—you'll hear the monks chanting their evening sutras and watch as the sinking sun paints the city in vibrant pinks and purples.
Land in an airport you won't want to leave
Singapore's Changi International Airport (truly, the best-run airport in the world) is not only clean and efficient, it's packed with perks you wouldn't expect to find in an airport—and that might make you not want to leave. It has a butterfly garden, a swimming pool, a gym, a spa, a movie theater, an arcade, a playground, and free tours of the city for those with a layover of five or more hours. Next up? It's getting a canopy bridge and two mazes.
Stuff your face with street food at a hawker center
Airport Road Food Centre has a couple dozen excellent food stalls, including Lao Ban. Join the queue for a small tub of soya: barely sweet, custard-soft tofu that satisfies, variously, as a dessert, an appetizer, a palate-cleanser, or a digestif. Maxwell Food Centre is another food court with even more stalls selling even more tempting dishesfrom everywhere across southern Asia. One of the iconic stalls is Tian Tian Chicken Rice, which serves, well, chicken rice—an utterly succulent chicken cooked in chicken broth and served with chicken broth–boiled rice.
Discover Singapore's unique Peranakan culture and cooking
An ethnic group specific to this part of Asia—created by the mostly Hokkien Chinese merchants and traders who arrived here and married Malay women—the Peranakans flourished from the 15th through the early 20th centuries. They developed their own language, a kind of Malay-Hokkien creole; their own dress; their own religion (a sort of Taoist Catholicism, if you can imagine such a thing); and their own cuisine, which married Chinese flavors and spices with the sugar and coconut of Malay cooking. Your menu at Peranakan restaurant True Blue might include simmered beef, gently seasoned with cardamom (a kind of Peranakan version of short ribs), or banana blossom salad with star fruit, or chicken stew with Indonesian black nuts. Just hope your meal ends with the addictive glutinous black rice porridge, which is gently sweet and pairs well with the longan tea that'll be served alongside it. The restaurant's decor—which features artwork, objets d'art, and furniture from chef-owner Benjamin Seck's collection—is as colorful as the food. If you ask, you'll even get to go upstairs to see a Peranakan Catholic altar. Although it's Chinese in style and color, you'll note that at its center is a depiction of the Virgin Mary, though rendered as a Qing dynasty–era figure. For more on the culture, you can check out the small Peranakan Museumnext door.
Find peace in Bali
Skip Bali's party-centric Kuta-Legian-Seminyak region, and set up instead in Ubud. The area is rightly celebrated for both its crafts and artisanship, as well as its emerald rice fields that morph slowly into jungle.
Sip watermelon juice while you walk through rice fields
If you're staying at our recommended Uma by Como hotel, within a short 20-minute walk, you can leave the din of Ubud behind and replace it with the sounds of running water, coconut fronds rustling in the breeze, the low drone of dragonflies, and the occasional local carrying a yoke from which green coconuts dangle. It's a delicious jolt: Just down the road is the 21st century in all its unstoppable modernity—although here, it could be anytime. But it couldn't be anyplace: This landscape is wholly Bali's. After 20 minutes or so, you'll come across Sari Organik, a juice-and-snack villa with extensive raw/vegan offerings, right in the middle of the fields. Stop and refresh yourself with a cacao bowl or watermelon juice.
Follow in the emperor's footsteps in Beijing's Forbidden City
To best experience the Forbidden City, the enormous walled 15th-century structure at Beijing's heart, later in the day is actually better. Skip the museum within the complex's grounds and head to the North Gate, going backward toward the main entrance at Tiananmen. This is where every emperor—and his family and staff—lived from 1420, when the 7.8-million-square-foot, 980-building compound was finished, until 1912, when the Qing dynasty went out with a whimper.
Walk the Great Wall—without all the tourists
There are a few main sections of the Great Wall that people visit. Badaling and Juyong Pass, which are among the closest to the city, are so densely packed with tourists that you might as well stay home. Then there's Mutianyu, about 90 minutes outside the city center, and Jinshanling, which is two hours away. Both options have their benefits. Jinshanling, which will be all but untouristed, is an especially nice choice if you want to walk a long section of the wall. If, however, your main goal is not to hike the wall but to just get a feel for it, opt for Mutianyu.
Be awestruck by the terra-cotta warriors of Xi'an
China's first ruler, the great emperor Qin Shi Huang, not only began construction on the Great Wall, but he's also responsible for the terra-cotta warriors of Xi'an. Shi Huang's secret remained just that until 1974, when three local farmers were digging a well and came across stone body parts. They reported it to their local official, and no sooner could you say, "Sorry, Shi Huang," than the eighth wonder of the world was discovered. But the emperor may have the last laugh: The terra-cotta warriors are in fact not part of his official tomb. They're an adjunct to it. The official tomb is about a mile away from the warrior site, and writings from that time record it as having mountains of jade and rivers of mercury, atop which the emperor's body could float forevermore. And, indeed, recent soil testing confirms high levels of mercury in the soil around the tomb (which is the largest in the world at about 22 square miles). However, given mercury's toxicity—and, again, the lack of proper technology—the government has stopped excavation work in the area. Which means, of course, that there may be a ninth wonder of the world yet to be unearthed.
Wind down a long day at the Summer Palace in Beijing
This enormous complex of gardens, official buildings, and pagodas was commissioned in 1750 by the great fourth emperor of the Qing dynasty, Qianlong, but is probably best associated with the so-called "Dragon Lady", the Empress Dowager Cixi (1835-1908), a formidable royal concubine turned regent who essentially ruled China from 1861 until her death, making a big mess of it along the way. The grounds are vast, and you could easily spend a day here, but you've come in the late afternoon when the crowds are thinning out and you can see the sun begin to make its creeping descent. Unless you're an aspiring Qing dynasty scholar, you won't need to see every last building and pagoda, but don't miss the spectacular covered hallway that follows the shore of the man-made lake, which was built to resemble the shape of a peach, the traditional symbol for longevity. This is the longest covered hallway in the world and is not only lovely, but functional: On a hot day, the hallway creates a sort of wind tunnel, with the breeze off the lake circulating coolly throughout the walkway.
Discover the Chinese contemporary art scene in Shanghai
The Chinese contemporary art scene is the country's most-buzzed-about export since silk itself. The Moganshan Lu gallery district has the highest concentration of galleries and makes for a fascinating afternoon looking at the fruits of a very young, booming market. But beware: While real, lasting talent has emerged from China's contemporary scene, there are scads of the merely trendy, the not-very-inspired, the ephemeral, and the downright bad (as there are in any contemporary art scene).
Discover Shanghai's Jewish quarter
You needn't be Jewish to find Dvir Bar-Gal's tour—and the history of Jews in Shanghai—mesmerizing. Although Shanghai found its footing as a commercial city in the 1500s during the Ming dynasty, it really took off in 1842, when the British signed the Treaty of Nanjing with the Qing government, which gave them access to a number of ports around China, including Canton and Shanghai. People from all over the world came to Shanghai to make their fortune. Some of the earlier and most powerful Westerners to arrive here were the Sassoons, a family of Baghdadi Jews who eventually came to control large swaths of not only the shipping trade but the real estate business as well. More Jewish groups followed, including Russians fleeing anti-Semitism, Bolsheviks, and, in the late 1930s, refugees from the Holocaust. It was estimated that 20,000 Jewish people were living in Shanghai in the late 1930s and early 1940s.
Glimpse a fading cultural icon in Kyoto's Gion neighborhood
If Japan has a face, it's to be found in this small district directly adjacent to Yasaka Shrine, for it's here that the geisha—or geiko, as they're known in Kyoto—live and work. Contrary to popular belief, geiko are not prostitutes. Yes, many of them once came from poor families—especially in the 19th century, when the geiko community was at its height—and yes, many have had powerful male patrons. But they are trained in the arts of dance, song, and especially conversation. Today, very few geiko remain; fewer than 1,000 still practice in Japan. "Geisha are so stunning and shocking to see in the streets," says photographer Darren Keith. "They're stoic, with amazing posture considering their high clogs. Sometimes they're surrounded by crowds, but for the most part they walk around totally unbothered."
Meander through a bamboo forest
No trip to Kyoto is complete without a visit to Arashiyama Bamboo Forest (sometimes referred to as Sagano Bamboo Forest). In the Heian period (794-1185), when Kyoto was not only Japan's capital but the center of arts and culture, this district was a summer retreat for nobility—it's cool year-round, but especially in summer. The dense stands of ancient bamboo—so green and silent that the very air seems to taste of dew—are at their quietest in the early morning.
Tour the world's biggest fish market
Tokyo's Tsukiji Market moves nearly 3,000 tons of seafood a day to restaurants, wholesalers, and grocery stores in Japan and abroad. Wander the rows and rows of stalls selling everything you've ever imagined could be pulled from the sea (and plenty of unidentifiable stuff as well). Just be sure to keep to the sides and steer clear of the motorized carts; this is a working market, after all.
Eat sushi for breakfast
Sushi for breakfast? Yep. There are dozens of tiny and delectable restaurants at Tokyo's Tsukiji Fish Market, but few rival Sushi Dai, where waits run an hour (or longer) as early as 6 a.m. The sushi is strictly omakase, or chef's choice, and is so fresh and perfectly cut that it seems to dissolve in your mouth.
See a fashion show on Tokyo's streets
Harajuku was once Tokyo's SoHo—all artists and punks. And like today's SoHo, it's now all luxury boutiques. But stop by on a weekend—when the kids are out in force—and it's the most thrilling fashion show you'll ever see.
Stroll pre-WWII Tokyo
Yanesen is the triangle formed by the old neighborhoods of Yanaka, Nezu, and Sendagi. These three neighborhoods—with their little streets and low-slung houses—are among the few that survived World War II bombings, and in them you can see what a humble, even cozy place pre-war Tokyo must have been. Today, the area is known for its small shops, bakeries, and eateries, most of which are independently owned.
Create a feast out of Japan's top-notch convenience store cuisine
How good is the food in Japan? So good that even pre-packaged and ready-made food in convenience stores (known as konbini and ubiquitous throughout any medium- to large-size city) is pretty darn spectacular. Stock up on limited-edition Kit Kats and Mitsuya Cider for a shinkansen ride…or after a long night of drinking. Best of all? Pretty much everything you'll find is well under $5 apiece.
Dine in a department store basement
Every department store in Japan—and there are many—dedicates its basement floor to a vast food hall. The Tokyu Department Store may not be as refined as, say, Mitsukoushi's, but god, it's fun: row after row of fresh fish (some of which was probably bought at Tsukiji that morning), vegetables and fruits in foam snugglies, and every manner of prepared food you can imagine (bentos, gyoza, sushi, rice balls, tempura). And that's just the Japanese side: Make sure you check out the bread and pastry section while you're there—just follow the smell of butter. And buy some snacks for later, as Japanese do not walk and eat.
Receive a jukai blessing
The jukai ceremony at the Garan complex in Koyasan takes place in a temple that's almost entirely dark. After chanting, the priest will call you up to receive from him a small paper charm upon which is inscribed Shingon's ten commandments. Kneel before him, bow your head, receive the paper with both hands, bow again, and return to your seat on the tatami mat in front of him. He will then deliver a brief sermon that will be translated by your guide. It's an utterly mystical experience: The priest appears as a black silhouette, the only light an illuminated painting of Kobo Daishi behind him, his voice and that of the junior priest's filling the air like smoke.
A perfectly planned trip made just for you is priceless! Let us design your Asia Adventure Holidays and make your entire experience- from start to end – hassle-free.
This article originally appeared in CNTraveler.com.


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Quick Facts
Skin Cancer
Get the facts about skin cancer, including the different types and symptoms.
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About Dr. Hakan N Thyresson MD
Dr. Hakan N Thyresson, MD is a Doctor primarily located in Newburyport, MA, with other offices in Haverhill, MA and Haverhill, MA (and 1 other location). His specialties include Dermatology. He speaks English.
Dr. Hakan N Thyresson has 4 locations
1 Wallace Bashaw Way
Newburyport, MA 01950
62 Brown St
Haverhill, MA 01830
60 Bailey Blvd
Haverhill, MA 01830
1 Park Way
Haverhill, MA 01830
Dr. Hakan N Thyresson has the following 1 specialty
- Dermatology
A dermatologist is a doctor who has extensive training and knowledge of the skin, scalp, hair and nails and treats conditions that affect those areas. These doctors will evaluate any abnormality, blemish or lesion on the skin in order to determine the cause and will determine a course of treatment.
Dermatologists provide patients with full body scans in order to identify any signs that are indicative of an illness that requires treatment, such as skin cancer. These specialists may also provide cosmetic services, such as mole removal, scar diminishing treatments and even botox and face lifts.
Specialty Expertise
Dr. Hakan N Thyresson has the following 5 expertise
- Psoriasis
- Melanoma
- Skin Cancer
- Acne (Acne Vulgaris)
- Acne Rosacea
Dr. Hakan N Thyresson Accepts the Following Insurance
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Please call Dr. Hakan N Thyresson's office for more information.
1 Wallace Bashaw Way Newburyport, MA 01950
62 Brown St Haverhill, MA 01830
60 Bailey Blvd Haverhill, MA : (978) 374-6770
1 Park Way Haverhill, MA 01830


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audio entropy daemonThis program feeds the /dev/random device with entropy-data read from an audio device.
The audio-data is not copied as is but first 'de-biased' and analysed to determine how much bits of entropy is in it.
This program is usefull for systems doing lots of cryptographic stuff like VPN endpoints or GPG clients; it helps preventing that the /dev/random device gets depleted and blocks reads.
Changes2.0.1: now also works on big endian systems
2.0.0: major bugfixes, added ALSA support
1.0.5: logging can now be switched of, code clean-up, help-output fixed
1.0.1: no longer exits when random data is not random enough, it now skips it and continues when data is random enough again
1.0.0: the buffer was only refilled once
0.0.7: added code which checks the quality of the random data


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It's time to test your scientific acumen — or your knowledge of a very specific musical subculture. Plenty of microbes have seriously badass names. Lots of metal bands have names that sound like weird microbial diseases. Can you tell the difference between Thergothon and Eperythrozoon? Take our quiz!
Here's how this works: below you'll find a list of 20 names. They are all either names of metal bands or names of microbial taxa (or, in some cases, both). Take a look at the list and keep score. Then head over to the answer key to find out which is which. You'll learn a few things about microbes and watch some metal videos along the way.
Microbiologists and Tolkien fans will have a slight advantage here.
1. Moraxella lacunata
2. Mortuus Caelum
3. Acidianus
4. Cirith Ungol
5. Paramaecium
6. Metalium
7. Metallosphaera
8. Schizomycetes
9. Serratia
10. Xenophilus
11. Anthrax
12. Circle of Dead Children
13. Nachtmystium
14. Toxothrix
15. Thermovorax
16. Amon Amarth
17. Thergothon
18. Eperythrozoon
19. Chromatium minus
20. Agathodaimon


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Nikki Sixx Blasts Kim Kardashian Via Twitter
Motley Crue bassist Nikki Sixx took socialite and all-around media . . . uh, "personality" Kim Kardashian to task on Monday (May 20), after the bad-reality-TV-star-turned-product pitch woman posted to Twitter to promote her new bronzer line during the horrific tornado that touched down in Moore, Okla. and struck an elementary school, reportedly leaving at least 51 people dead in its wake.
"Love that I can gradually build the perfect bronzed glow I want with #KardashianSunKissed Tan Extender w/ Bronzers!" the apparently oblivious Kardashian tweeted to her enormous brood of more than 17 million Twitter followers Monday afternoon.
Meanwhile, Sixx was tweeting, "PLEASE Text "REDCROSS" to 90999 for $10 donation to help tornado victims in #OKC Sending out our prayers." He was joined across the blogosphere by other celebrities and their followers who were all pulling together to try to do whatever good they could in getting information out for those who wanted to help. When Kardashian's tweet came to his attention, Sixx lost his patience and posted, "Pick your priority or pick your poison. Pretty embarrassing screen shot Kim. Isn't your 15 minutes up…" accompanied by the following image:
The debutante and reality TV princess, who shot to fame on TV's 'Keeping Up With the Kardashians' after making her public debut in a widely-seen sex tape, did not reply directly to Sixx, but did post a photo to Instagram later in the day that said, "Praying for Oklahoma."
Her followers will also undoubtedly be interested to know that, according to a later tweet, "My pregnancy lips are outta control."


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The timeless as well as striking premium collection Hommage by Villeroy & Boch impresses with linear forms and a blend of marble and real wood true to style. Inspired by the early 20th century, Hommage combines timeless design elements from a great era, thus adding special touches to the luxurious Villeroy & Boch bathroom.
Whether for hand towels or shampoo, a stylish bathroom cabinet by Villeroy & Boch has plenty of storage space for everything. It makes it fun to keep things tidy and it looks good too. It's very easy to add highlights with shelves, tall and side cabinets by Villeroy & Boch. Select from many designs, sizes and colours to find the perfect cabinet for your bathroom.
The modern SoftClosing technology closes drawers and doors silently and gently, even when force is used. The SoftClosing mechanism slows down the drawer and automatically closes it, slowly and silently – not only is it pleasant to the ears, it is also gentle on the bathroom furniture.
The full extension allows drawers and pull-outs to be opened to their full depth. This ensures that the entire contents is visible and convenient to reach. No annoying rummaging around in the back of the drawer – bathroom furniture with full extension gives you the full overview.
CeramicPlus - the anti-dirt surface for sanitary ceramics - simplifies bathroom cleaning. This innovative process causes water to immediately form droplets on contact, which then merge into beads and simply drain away, carrying dirt and limescale particles with them.
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Wood. hinges on right. Equipped with: 1x drawer, 1x door, 1x shelf, 1x marble countertop. Equipped with: 1x shelf, 1x door, 1x drawer, 1x marble countertop


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Ocean acidification is one of the major effects of increased carbon dioxide levels in the atmosphere caused by the burning of fossil fuels (coal, oil, gas). Museum collections of samples from the ocean bottom worldwide are housed at our Wandsworth outstation and are vital to working out how much more acidic the oceans have become since the 19th Century and to helping create models for future changes.
Three bottles of ocean sediment collected in 1891 as part of the H.M.S. Penguin cruise to the Mediterranean
Our outstation at Wandsworth holds the Mineralogy Department's Ocean Bottom Sediment Collection. These are sediment samples from many cruises including the first oceanographic voyage the Challenger Expedition of 1872-1876. I mentioned previously that we hold residues including microfossils at South Kensington so why are these bottles of sediment at Wandsworth of interest to micropalaeontologists?
Potentially these bottles contain many thousands of microfossils (the ones above mention the foraminferal genus Globigerina) and as a result, they have been of interest for two PhD students studying the effects of ocean acidification on micro-organisms.
Open University PhD student Kate Salmon accessing the Ocean Bottom Sediment Collection at the Museum outstation at Wandsworth. Curator Dave Smith is in the background.
Kate Salmon is using mainly foraminiferal microfossils to measure the scale of ocean acidification in the area around Bermuda. To do this she is studying samples collected every 2 weeks for the past 20-30 years in sediment traps on the ocean bottom.
The weights and shell thicknesses of these micro-organisms that use the ocean water to produce their shells of calcium carbonate should be different in pre-industrial samples. If ocean acidification is happening we should see lighter more fragile shells in the present day. Kate is using the Ocean Bottom Sediment Collection at the Museum to find comparative material from pre-industrial times.
Kate recently told me, 'If I do the same shell analyses on these samples, it will give a good comparison of low carbon dioxide conditions with higher carbon dioxide conditions (present day) and I will be able to see how conditions have changed for the calcifying biology of the oceans. I can then use these results to predict any future changes in the calcification of foraminifera and the implications this will have for other creatures living in the water column'.
Part of the residue collection from the H.M.S. Penguin expedition collected in 1891.
Ella Howes, a student at the Laboratoire d'Océanographie de Villefranche sur Mer, France approached us to see if we had any sediment including the remains of tiny organisms called pteropods. These are small planktonic gastropods (floating snails) that have been used extensively in ocean acidification studies. Ella has recent material from near Bear Island in the Mediterranean and wants to compare the composition and structure of these faunas prior to major industrial activity.
She is searching for a particular pteropod species Limacina helicina as well as foraminifera. As with Kate Salmon, she is looking to make measurements of shell thickness to assess possible outcomes of ocean acidification between the Mediterranean and colder water areas.
'In Polar regions the cold temperatures allow increased carbon dioxide in water, potentially causing more extreme repercussions for animals living in these areas. A geographical comparison between the effects on ocean acidification on shell thickness in Polar pteropods and the warmer Mediterranean Sea will be undertaken using modern samples of Limacina helicina and old sediment samples provided by the Natural History Museum' says Ella.
Part of one of four rows of cabinets containing the Ocean Bottom Sediment Collection at the Museum.
When you consider the quantity of material at our Wandsworth outstation, there is limitless potential for similar studies to be carried out. There are literally millions of micro-organsims from the ocean bottom waiting to be studied. Listings of these collections can be found on the Museum web site. In the meantime, I will wait with interest to hear from Kate and Ella if a trip to Wandsworth can help quantify ocean acidification.


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Each piece of the dock is washable, and care instructions are below for each piece (for more detailed instructions please refer to the label on the bottom of your dock cover). We do not recommend using bleach on any part of your dock - stain remover is preferred.
Outer Cover: Machine wash in cold water inside a garment bag and hang to air dry (to help avoid color bleeding for covers with prints, be sure to immediately hang to dry after machine cycle is finished and ensure there are no folds or overlapping when drying). Do not tumble dry. Do not bleach. Do not dry clean.
Pad: Hand wash in cold water and lay flat to dry. Do not tumble dry. Do not iron. Do not bleach. Do not dry clean.
Inner Sleeve: Machine wash in cold water and hang to air dry. Do not tumble dry. Do not bleach. Do not dry clean.
Inner Tube: The tube rarely needs washing, shaking and ventilating are usually enough. If washing the tube, machine wash in cold water inside a garment bag and then tumble dry on low heat only. You can shake or fluff to redistribute the filling as necessary. If still damp, lay flat to dry. Do not iron. Do not bleach. Do not dry clean.
Mum Stories
Ideal for Co-Sleeping/Bed Sharing
With rounded sides, the DockATot helps create a barrier between baby and parents to give your child their own cozy space. When used in an adult bed properly, DockATot offers a better way to co-sleep.
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DockATot is made in the EU with OEKO-TEX certified fabrics that do not harbor heat. This ensures that the micro-climate (space directly affecting their surroundings) is the best possible for baby.
Facilitates Tummy Time
DockATot is the ideal spot to have tummy time with your little one. When baby is awake and ready to play with you, the rounded sides help to prop up your baby when placed under his/her arms. Tummy time can help babies develop neck strength and motor skills. It is important to closely supervise your baby during tummy time.
One of the most amazing aspects of the DockATot is its ability to serve so many purposes. When you purchase a DockATot, you're actually getting a resting, bonding, playing (with the addition of toy accessories), nursing and changing product in one stylish package. DockATot is one of the most used baby items and provides easy portability with a compact design that makes it easy to move around the house or anywhere you travel.
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The DockATot is an ideal travel companion for moms with babies and toddlers, as it maintains familiarity in a new environment. We offer stylish and functional Travel Bags to help keep your dock protected while on the go.
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Quality craftsmanship
The Deluxe+ Dock is the ultimate Stage 1 docking station for your baby ages 0-8+ months old. Multifunctional and multitasking, the DockATot® Deluxe+ offers a safe and comfy spot that lets baby rest, lounge, play, cuddle, do tummy time and get diaper changes.
Read more about sizing.
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By reinventing a womblike environment, the multi award-winning DockATot offers a most gentle womb-to-world transition to soothe your precious newborn baby.
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Lightweight and portable, the DockATot replaces your baby travel cot on family adventures offering your little one soothing familiarity wherever you roam. The DockATot collection also includes Travel Bags to protect your baby lounger and Spare Covers when baby makes a mess.
With thousands of verified 5-star reviews, the Swedish-designed DockATot is a global parenting must-have and invaluable sleep cue.
Made with love in Europe, all materials are breathable, washable and hypoallergenic. Dockatot™ offers excellent air-permeability. All filling materials are sourced from world-leading suppliers with hygienic and non-toxic properties.
So rest easy mamas… the DockATot is the next best thing to having your baby in your arms. When your baby says 'snuggle me', just grab your DockATot!
(And soon-to-be Aunties and Grandmas we've got you covered too, the DockATot is the perfect baby shower gift for the new mama and baby in your lives!)
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Safety Note: DockATot is to be used in a supervised setting only. It is not to be used in baby cots, bassinets, baby beds, travel cots, baby bouncers, co-sleepers or other types of baby furniture. For best practice, please review our Safety Guidelines.
0-8M, Stage 1
2.2-10kgs, Stage 1
46cm wide x 74-86cm long [74cm with clasps closed and 86cm with clasps open]
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Earlier this week we showed you the inside of Derek Low's insanely automated college room. Sadly, the draconian forces that be at Berkeley are calling Low in to a judicial hearing because his room violates their housing policy.
In his own words, Low spent "three months and several hundred dollars" tweaking his room, and now some academics have decided he can't have fun any more. How pathetic.
Still, Low doesn't seem too concerned. He's planning to move out and get himself a personal apartment in the next two weeks. Take that, Berkeley. [Innovation News Daily via Venture Beat]


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Relax, my pretties. "Oz the Great and Powerful" is a lollapalooza of funhouse thrills and visually sumptuous filmmaking. The film opens with such a flourish and bang that some viewers may feel they've been swept up in a tornado themselves.
Respectful of the classic original film but never timid, "Oz" represents the dizzy high point of Sam ("Spider-Man") Raimi's considerable career. He directs with skill and velocity, tossing another unsuspecting Midwesterner into a whirlwind that leads to a dazzling land of munchkins and airborne monkeys. This time it's not a brave farm girl in braids who makes the trip, but Oscar Zoroaster Diggs (James Franco). He's a traveling-circus magician of minor achievements, scientific aspirations (his hero is Thomas Edison, "the wizard of Menlo Park") and grand self-regard.
The smugness that has soured some of Franco's work suits a character who would rather be great than good. He makes a young, svelte, rather hot conjurer who has broken many a heart, including that of Dorothy Gale's mom-to-be (liquid-eyed Michelle Williams, resplendent in a blonde wig). Franco's strained smile hints at inner misgivings. Other Oz characters have wanted brains, heart or nerve; Diggs needs a soul.
Raimi's keen sense of style serves the material well. The film's black-and-white opening captures the drab, threadbare world of Dust Bowl Kansas with claustrophobic, boxed-in shots that could have been lifted from a 1930s B movie. When storm-tossed Diggs floats into Oz in his hot-air balloon, the film image expands to widescreen proportions as lush lollipop hues gradually saturate the frame. The sets explode with color and detail, as seamless and believable as a land of imagination can be.
In Oz, the happy hypocrite finds his niche, a wonderland whose naive populace take him for their long-foretold savior. He's quick to take advantage, first of Mila Kunis, playing a ravishing young witch who falls for his well-practiced come-ons. Her sister witch, regal Rachel Weisz, seems equally taken by the handsome newcomer. Kunis is traumatized, the tracks of her tears furrowing into her cheeks as dainty scars. Williams reappears as the land's most purehearted witch, gazing at the bumbling, blowhard Diggs with knowing, tolerant affection.
The plot is a complicated skein of unrelated fairy-tale elements. We encounter Franklin, a humble winged monkey; China Girl, a cream-skinned porcelain doll with wistful bright blue eyes; and Knuck ("Bad Santa's" diminutive Tony Cox), a testy court herald. There is some metaphorical malarkey about building a family out of the defective materials you're given, but it's just so much filler.
The payoff is a whirligig climax in which Diggs fights the cackling, fireball-throwing, lightning-fingered forces of bad magic. He wins the day literally with smoke and mirrors. Raimi has great fun with the fake wizard's command of theatrical illusion amid his lovingly rendered world of cinema magic. The special effects are appropriately out of this world.
While there's really not a performer here who ranks with Judy Garland, Ray Bolger or Bert Lahr, there's plenty in this enormous production to charm the adults and wow the junior members. China Girl (voiced by Joey King) should sell a million dolls come holiday season, and Franklin (voiced by Zach Braff) is so endearing that pet shops will be flooded with monkey requests. Unless my crystal ball fails me, families will be off to see this wizard again and again.