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Legionnaires' disease is a serious lung disease which is caused by breathing in aerosols infected with the bacteria Legionella Pneumophila. Of those who are infected up to 30% will die.
The bacteria got its name in 1976, when 4.000 US. Legionnaires went to the 58. American Legion Convention in Philadelphia. At the conference 221 legionnaires were infected with the bacteria whereof 34 died. This was the first diagnosed outbreak of legionnaires disease.
Legionnaires' disease has the same symptoms like other forms of pneumonia, which makes it hard to diagnose. Symptoms are high fever, chills, coughs, muscle aches and headaches. Chest x-rays are needed to find the pneumonia caused by the bacteria, as well as blood or urine to find evidence of the bacteria in the body.
To catch the disease the bacteria must be inhaled. Infection occurs after inhaling a fine aerosol of bacteria contaminated water droplets. The infection rate is typically 5%. The fatality rate is up to 30% of those who are infected. Typical sources of infection are showers, cooling towers, spas, whirlpools, swimming pools and water fountains. The bacteria do not spread from one person to another.
Legionnaires' disease is a serious disease. However, most cases are treated successfully with antibiotics, and healthy people usually recover from infection. The symptoms usually begin 2 to 14 days after being exposed to the bacteria.
A milder infection caused by the same type of Legionella bacteria is called Pontiac Fever. The symptoms of Pontiac Fever usually last for 2 to 5 days and may also include fever, headaches, and muscle aches. However Pontiac fever is not lethal.


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Get up Bitch(x16)
I grew up wit da goons
So what the fuck you think
That made me
I'm not a game so ain't no muthafucka
Played me, I got whips, and I am not
A slave see and im gon' ball like a
Muthafucka shave me (repeat 1x)
[Verse 1:Juicy J]
Mac 11 on my seat wit' a silencer
Nigga run up off the street I'ma fire her
I'm a king bitch, gon' kiss these rings bitch
Gon' suck it, roll another light that flame bitch
I'm rich to the end might as well spend that shit
Money on my plate might as well finish it
Spaceship high smokin' out wit' E.T
I don't give a shit I'm smokin' out on TV
Wearin' a chinchilla, poppin' a few pillas
Buy alotta' medical, keep a couple of dealers
New cars, new hoes, call me Flip Wilson
Walkin' in a club with somethin' like Keri Hilson
[Hook x2]
[Verse 2]
O.K. this is verse two
That means that it's blunt two
My eyes like a Chinese mane you can call me Bruce (Lee!!)
It's cloudy in the booth
My blunt is almost through
Maserati outside, two doors no roof
Which one of you niggas say you want it wit juice
I ain't Jesus but I'll show yo ass da truth
Don't get scared when I turn them cannons loose
[Hook 2x]

subset: commoncrawl


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Police: Naked man caught smashing cars
Police said they caught a naked man smashing out tail lights Wednesday morning.
Iowa City police officers were dispatched to 714 Westwinds Dr. at 6:25 a.m. Wednesday for a report of a naked man trying to get into cars and hitting cars with a bottle.
Responding officers said they witnessed 42-year-old Sean C. Flaherty smashing out tail lights with a glass bottle.
KCRG-TV reports police took Flaherty into custody, who admitted to being drunk. Flaherty had bloodshot, watery eyes and smelled strongly of alcohol, police said.
According to police, a Breathalyzer test showed he had a blood-alcohol content of .083 percent.
Flaherty broke out the tail lights of three different cars, according to police. He told police he was targeting the red tail lights because "red means danger to the republic," according to criminal complaints.
Police estimate the total damage to the cars to be $600.
Flaherty faces charges of criminal mischief and public intoxication.


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Hi Giles,
I seem to be having an issue with all sound dropping out of the game, seemingly permanently.
This happened on Saturday, and the really weird thing is that it happened on both Minotron AND Minotaur Rescue, the same day.
At first I thought it was a prob with my device, either a global setting perhaps, or the actual hardware, however every other app and game on the same iPhone (and there are quite a few) continues to work just fine, sound-wise, while the two Minotaur games remained silent.
I couldn't see any sound option in-game to tweak, other than the in-game volume level one, which makes no difference, so not sure if I'm missing something or not? So apologies if it's something really obvious that I've missed!
I wound up deleting Minotaur Rescue off the device and reloading it from iTunes on the PC, which seems to have sorted that one, i.e. restored the sound, but before I did the same with Minotron I thought I'd drop you a line to see if anyone else had reported the same issue?
PS The games are on a 16GB iPhone 4, not sure of any other tech details as it's my partner's phone and I don't have it with me, but it's the latest iteration, only two or three weeks old.
Total sound drop-out?
Support forum for Minotron
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This week, we look at Facebook's new Groups and Download features, Twitter's new CEO, CNN's Rick Sanchez vs. Jon Stewart, Apple hit with $625.5 Million patent violation, Android moves ahead, Apple preps an iPhone for Verizon, Google TV gets more real, Goo.gl gets a website, an alternative to JPEG, Google goggles comes to the iPhone, and Search terms Google Instant doesn't want you to see.
The Drill Down 156 – Shrimping? Get my Sister.
The Drill Down 156 Play Now | Play in Popup | Download (1198)


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In a perfect world, there would be no work, no offices, no deadlines—but as you and me both know, the world ain't perfect. So, it would be nice to get a little more buck for our hard work, right?
The Senate is currently hashing out what to do about the meager $7.25/hour minimum wage—specifically, if it should be raised and by how much. Speaking at a recent committee hearing, Massachusetts senator Elizabeth Warren brought up the point that, if the wage had increased at the same rate as workers' productivity across the U.S. did, it should be at about $22/hour by now.
Which, suffice to say, would majorly kick ass.
Sadly, this increase policy would have had to start decades ago in order for minimum wage to get that high (since it would have taken years of steady increases to reach the over-$20/hour mark ). And Warren isn't necessarily advocating for the wage to raise to $22—she was just bringing up an important point about how low minimum wage really is and where it could be.
Still, we have to wonder how much better off students and just-out-of-college grads would be if minimum wage jobs were a bit more lucrative. (Not to mention anyone working for minimum wage.)
All we know is the current $7.25/hour just doesn't cut it, especially when we've got massive student loans and other bills to pay. So we hope that Warren's comments will spark some action—and put a little more cash in our purses.
Want more from Natasha? Follow her on Twitter or find her on Facebook.
Photo: ABC/Rick Rowell


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North Sea and Norway to Sweden and Gulf of Bothnia63.5N 12.4E
This image stretches across Norway (left), on the coast of the North Sea and the Norwegian Sea, to Sweden (right) and the shores of the Gulf of Bothnia. The two countries are separated by the Scandinavian mountain chain (Skanderna).
The coast of Norway is rugged, broken by huge fjords and thousands of islands. The fjords, best observed in the full image, appear as dark blue line reaching inland from the coast.


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Loyalty Offer : $500 cash back on select Kia models
Manufacturer Offers
- $500 cash back
Applies to multiple models. See Trims
The standard features of the Kia Soul EV Base include 109hp engine 1-speed automatic transmission, 4-wheel anti-lock brakes (ABS), integrated navigation system, side seat mounted airbags, curtain 1st and 2nd row overhead airbags, airbag occupancy sensor, automatic air conditioning, 16" aluminum wheels, cruise control, ABS and driveline traction control.
Applies to multiple models. See Trims


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- Search for JobsSearch for Jobs
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Pharmacist (Floater)
Jobs Rated33rd
Job Description
The primary purpose of this position is to assist customers with their health care needs by filling prescriptions, providing clinical services and excellent customer service while supervising Pharmacy associates. Frequent independent judgments are essential. All duties described in this document are to be performed in keeping with the core values and service attributes consistent with the Rite Aid brand and strategy.
The associate is responsible for the functions below, in addition to other duties as assigned:
- Ensure the accuracy and appropriateness of all prescriptions filled by completing Drug Utilization Review and Final Quality Assurance, applicable to state and federal Board of Pharmacy regulations.
- Build profitable business and script growth through recommended clinical programs including appropriate immunization and when available MTM (Medication Therapy Management), DCS (Diabetes Care Specialist), and all ongoing other programs as identified.
- Provide excellent customer service by assisting customers with medical-related issues and providing healthcare counseling.
- Supervise the work completed by support staff while on duty.
- Assist with training, coaching and managing the pharmacy associates and assume management responsibility over the entire pharmacy as needed.
- Maintain appropriate security of the Pharmacy department.
- Comply with HIPAA and all other applicable federal and state laws and regulations.
- Handle and resolve customer issues, complaints and questions to build customer trust and loyalty.
- Interact with physicians and utilize reference material to gain information on customers and prescriptions and to resolve any issues that arise.
- Assist with maintaining the Pharmacy department by keeping it clean and in order.
- Prioritize Pharmacy Department tasks and follow through to ensure all tasks are completed in a timely manner. Including, but not limited, to cycle counts, inventory management and will-calls to customers.
Experience / Requirements
- Ability to work a flexible schedule to meet the needs of the business.
\u2022 Bachelor's degree (BS/BA) in Pharmacy or Doctoral degree (PHARM.D.).\u2022 Immunization Certification through an accredited organization (i.e. APhA).\u2022 Active Pharmacist license in good standing in the state for which you are applying.
* The above information represents a summary of the functions and requirements of this position. Additional details are available on the full job description.
Jobs Rated Reports for Pharmacist
Rite Aid is committed to bringing in individuals who support our personal approach to serving customers.
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County Court Judge Biagio DiStefano ordered not to hear criminal cases
WAMPSVILLE >> Madison County has only one judge hearing criminal cases.
All of the county's criminal cases since January have been heard by County Court Judge Dennis McDermott, leaving County Court Judge Biagio DiStefano to only hear family court matters.
Cases that were docketed late last year for DiStefano have had to be rescheduled for McDermott.
Why this is happening is unknown.
In January, DiStefano declined comment on the issue; however on Monday, he confirmed that he has been ordered to not hear criminal cases in Madison County.
He can hear criminal cases in Chenango County.
It was not immediately clear if DiStefano was still hearing surrogates court or civil cases in Madison County.
DiStefano declined to provide more information, referring all further questions to Sixth Judicial District Administrative Judge Robert Mulvey, the office that sources say originated DiStefano's order.
Mulvey declined to comment when reached by phone on Monday
He stated that it's a court operations matter and he does not comment on those.
According to state law, a complaint can be made against a judge to the administrative judge for the judicial district in which the court resides, in this case Mulvey, or by contacting the New York State Commission on Judicial Conduct.
Previously, Marissa Harrison, spokesperson for the commission, said her office can neither confirm nor deny any particular case is filed with the commission.
"All matters are confidential," she said.
The State Commission on Judicial Conduct receives and reviews complaints of misconduct against judges in the unified court system, which includes state, county, municipal, town and village courts. After reviewing a complaint, the commission decides to investigate or dismiss it.
Complaints that may be investigated by the commission include improper demeanor, conflicts of interest, bias, prejudice, financial and records mismanagement, among other offenses.
After a formal hearing, the commission may dismiss the complaint or caution the judge privately. The commission may also determine that the judge should be publicly admonished or censured.
Determinations to admonish, censure, remove or retire a judge are subject to review by the state court of appeals.
DiStefano was first elected county court judge in 1998, and re-elected for a second term beginning in 2008 that lasts until 2017.
He is still the pistol licensing official for the county.
Madison County District Attorney William Gabor was unavailable for comment on how the rescheduling will affect the flow of his cases through the system.


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Missouri minimum-wage workers see small pay hike
State raises minimum by 10 cents per hour
The new year brings a pay raise for nearly a million Americans, including many in Missouri, who earn the minimum wage.
Missouri is one of the states that has raised the minimum wage for workers, a raise that will mean an extra $4 per week for a full-time minimum wage employee.
Adam Fulkerson currently earns a minimum wage paycheck at his new job working at Burger King. He said he hopes that job will allow him to live on his own and possibly go on to college.
On Monday, his job paid $7.25 per hour. Starting Tuesday, it went up to $7.35, the first increase in Missouri since 2009.
"(It's) more money for your bills," he said.
Liam Whittaker said he was making minimum wage when he first started bagging groceries.
"I only got $150 a week when you get paid weekly," he said.
Fulkerson said the raise may not seem like a lot, but it puts him 10-cents-per-hour closer to freedom.
"Here and there, whatever helps, right?" he said.
The minimum wage in Kansas remains at $7.25.


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Brittany, France
I just returned from a week at the beach in a tiny town called Larmor-Plage in Brittany, France. It made me nostalgic for my childhood summers spent in Montauk. It has it all if you want to relax--gorgeous beaches and the best creperies around. My friend Erik Swain took this photo above of his vacation in Larmor-Plage last August. It really does capture the simple, lazy days of summer. While most of my friends headed south, I went to Western France. This little slice of heaven is a place where you can breathe, soak in the warm weather, and enjoy the peaceful space. I am so sad that we had to say goodbye, but until next year. A Bientot!
even on a cloudy day, Brittany is beautiful...


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Pioneer Lullaby
1. Low, lie low, my dear little one,
Under the starlight, under the sun.
Under the bluebells, under the grass.
Low,—lie low as the solemn wheels pass.
2. Yesterday, yesterday two little feet
Ran through the meadow, the wildflowers sweet.
Snowtime and flowertime cover you deep.
Low,—lie low as I lay you to sleep.
3. Blessed, oh blessed the day of our Lord,
Blessed the dead—who rise at his word,
Blessed the angels who swing wide the door.
Blessed the time when I hold you once more.
Blessed the time when I hold you once more.
Text: Virginia Kammeyer
Music: David Zabriskie
Artist: Kammeyer/Zabriskie
Album: Music Published in the Church Magazines: Ensign
Composition Date: 1980-06-01
More Info: Ensign


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Work and Self-Reliance
Get answers to questions about the standards of the Church. Choose a topic above to see more.
Why should I avoid gambling?
"Gambling is wrong and should not be used as a form of entertainment. It is addictive and can lead to lost opportunities, ruined lives, and broken families. It is false to believe that you can get something for nothing" (For the Strength of Youth, 41).Close
What does self-reliance mean?
"When you are self-reliant, you use the blessings and abilities God has given you to care for yourself and your family and to find solutions for your own problems. Self-reliance does not mean that you must be able to do all things on your own. To be truly self-reliant, you must learn how to work with others and turn to the Lord for His help and strength" (For the Strength of Youth, 41).Close
How can I become self-reliant?
"You can become self-reliant by (1) taking advantage of educational opportunities; (2) practicing sound principles of nutrition and hygiene; (3) preparing for and obtaining suitable employment; (4) storing a supply of food and clothing to the extent the law allows; (5) managing your resources wisely, including paying tithes and offerings and avoiding debt; and (6) developing spiritual, emotional, and social strength.
"In order to become self-reliant, you must be willing to work. The Lord has commanded us to work (see Genesis 3:19; D&C 42:42). Honorable work is a basic source of happiness, self-worth, and prosperity" (True to the Faith, 185).Close
How can I learn to work hard?
"Learning to work begins in the home. Help your family by willingly participating in the work necessary to maintain a home. Learn early to handle your money wisely and live within your means. Follow the teachings of the prophets by paying your tithing, avoiding debt, and saving for the future" (For the Strength of Youth, 40).Close
What's wrong with wasting time?
"The Lord has commanded us not to be idle. Idleness can lead to inappropriate behavior, damaged relationships, and sin. One form of idleness is spending excessive amounts of time in activities that keep you from productive work, such as using the Internet, playing video games, and watching television" (For the Strength of Youth, 40).Close
Why should I learn how to work?
"Work is honorable. Developing the capacity to work will help you contribute to the world in which you live. It will bring you an increased sense of self-worth. It will bless you and your family, both now and in the future" (For the Strength of Youth, 40).Close


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Course Description
HS 344 Archival Management 4 cr.
- Offered: Winter semester of odd-numbered years
Examines the knowledge, theory and skills required to manage archival information. Reviews the nature of information, records, historical documentation, research methodologies and the role of archives in modern society. Practical exercises emphasize theories and skills required to implement archival functions and research methodologies.


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The home-improvement and design shows make it look easy: Take a simple sheet of inexpensive plywood and presto! In a few minutes, you've got a table, a cabinet or a lounge chair.
It's not that fast or dirtcheap, but it can be that easy, according to woodworking experts who speak fondly of plywood's many merits.
"Plywood is the starting point for many of the things I build," says artist and designer Jimmy DiResta of New York City. "With some imagination and inventiveness it can become anything."
Plywood is cheaper and often stronger than solid wood, easy to find at homeimprovement or lumber stores, and — darn it — it looks good.Plywood is made from thin layers — called plies, or veneers — glued together under heat and pressure, with each ply laid perpendicular to the next. This "cross-graining" gives plywood its strength and stability, says Philip Schmidt, author of "PlyDesign" (Storey Publishing, 2012).
Since plywood comes in more than a dozen standard thicknesses and twice as many grades, check a buying guide — Home Depot has one online — before purchasing it. Schmidt recommends using a cabinet-grade material, such as Baltic birch, for do-it-yourself projects. The plies are thin and even, and the exterior is smooth, sanded and blemish-free.
"Beluga caviar notwithstanding, Baltic birch plywood may be Russia's finest export," Schmidt writes in his book. "PlyDesign" includes 73 projects for novices and experienced builders. Do-ityourself project magazines such as Ready Made and Make, and online sites such as Instructables offer many other ways to use plywood.
"Plywood is inherently modern, if you think of modern as starting in the 1920s," says Schmidt, of Denver. "It's still beautiful wood . and it's really easy to work with."
A jigsaw can cut straight lines and curves, so that's your primary tool, says Schmidt. After that, invest in a good-quality drill. If you want to go deeper into plywood DIY, get a circular saw and a router, which helps cut out multiple pattern pieces.
"I don't own a table saw or any stationary power tools," says Schmidt, a project designer and author of 17 design books. "I'm more into DIY."
DiResta recommends the jigsaw and circular saw for most plywood projects, and suggests starting out by building a storage box or simple bench. He offers video tutorials on YouTube, sponsored by Make magazine.
Plywood has its drawbacks. Schmidt warns against sand-papering through the thin top layer, ruining the look of your piece. To avoid this, use a fine-grit sandpaper, and be careful.
DiResta warns against splinters. A few years ago, he inadvertently brushed a palm against a cut edge, and a matchstick-size splinter went through his palm. He recommends wearing gloves when cutting plywood, and sanding cut edges with a sanding block.
Then there's "the edge thing," as Schmidt calls it: Do you cover the exposed plywood edge or let it be?
Design will dictate, both DiResta and Schmidt say. Some modern-looking pieces look great with their plywood edges exposed, and the better quality the plywood, the better it'll look. For other projects, you may
want to cover that edge with veneer. "Exposing the edge strata of the panel is really cool," says Schmidt. "It's a nice design element that you can work with."
For some, a project is too delicate or the plywood too high-end to entrust the cutting to one's own hand. If that happens, find a local furniture design business to cut the piece for you. They use computer-controlled routers that make precise cuts.
Denver furniture maker Scott Bennett works with birch-and-alder plywood to make storage and shelving pieces for his company, Housefish. Occasionally, he's asked to cut a one-off piece for a designer or DIY enthusiast. The cost is less than most people expect, he says, averaging about $100 per hour of work.
"Considering how many hours you might spend trying to cut a complicated shape with hand tools . spending a couple hundred dollars to have a computer cut out your parts can be a good way to get into DIY projects," Bennett says.
He recommends investigating the online site Ponoko, which provides laser-cutting services, but says most cities will have a few businesses that can handle an outside precision-cutting job.
Comments are not available on this story.
Send questions/comments to the editors.
Letter to the editor: Do the math – a lot of politicians have been in office too long
Letter to the editor: No need to learn more about neighbor with Trump sign
The Forecaster
People & Business: Oct. 21
Times Record Opinion
Commentary: Biden's plan to revive Iran talks could calm the Middle East – but on Israel he and Trump largely agree
Times Record
From the Chamber: The impact of the Midcoast Tree Festival, Part I


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Once Again Nut Butter
Our Mission:
Once Again Nut Butter is a democratically operated employee-owned workplace. We pride ourselves in providing the health-conscious consumer with products of superior quality and integrity. Located in a small rural community, we are dedicated to supporting organic and sustainable farming practices. We are proud to offer a healthier alternative, where every customer matters.
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Discover for free which first names would suit you or your baby !
Meaning of name Kinkata
Etymology :
Saint :
Origin : Japan
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Gender : boy
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Numbers :
Meaning of those numbers?
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Who is he?
Kinkata is a complex and elusive man. Two opposing components are included in his name: a male tendency: hot-tempered, excitable, enthusiastic, assertive and passionate (a combination of karmic 1 and 8 - even more pronounced if his birthday is a 1st, 8th, 10th, 17th , 19th, 26th, 28th, or if his life Path Number is 1 or 8), and a tendency to be nervous, internalized, secretive, shy or even inhibited (the influence of 7, a trend which is accentuated if he was born on a 7th, 16th, 25th, or if he has a life Path Number of 7). Be that as it may, it also confers him a certain magnetism, of which he isn´t always entirely conscious. Kinkata is extremely sensitive, although he has trouble expressing his emotions. He frequently feels as though he is never fully understood... which is normal because his reactions can be quite unpredictable! Depending on the moment, he could just as easily react violently or callously as withdraw into a more or less painful oversensitivity, and yet he is in perpetual search of harmony, with a desire to please and be appreciated in return. He could be an aesthete or cultivate an artistic hobby. He is industrious however his efforts can be inconsistent due to his tendency to go to extremes, either dedicating himself entirely to his work without counting the hours; or recovering and taking refuge in total inactivity. He can sometimes be torn between his pragmatic and materialistic mind and a certain idealism that can make him deviate from rationality and turn to spirituality or the irrational. He has remarkable intuitive abilities and a talent for psychology, even if he doesn´t always like to admit it... As a child he wants to be tough, and spends a lot of energy thinking about his future. His parents should try and avoid upsetting him and promote his verbal communication skills. A brilliant student, Kinkata could do well at school (presence of 7), however he can also be self-taught thanks to his unquenchable thirst for knowledge.
What does he like?
He likes to shine and to be admired, enjoying the attention but also wishing to set an example for others, and he doesn´t hesitate to employ his innate theatrical talents to this end. He could even put on a wonderful show of being the odd-man-out, original, eccentric or marginal. When his intellectual side is predominant, he is likely to be keen on psychology, anthropology, astrology and spirituality... He professes reactionary views or by contrast, revolutionary convictions, beneath a cynical, critical and scathing attitude. In matters of the heart, he is fiery and passionate, although not particularly sentimental; and can be very generous, provided that his authority is recognized and undisputed! He hopes that his sweetheart will look after him with care and attention, while he could prove to be as jealous as a tiger!
Get your free Personality test card now !!
What does he do?
This multi-faceted character also has multiple options concerning his career: if 8, 17 or 26 correspond to his birthday (or if he has a life Path Number of 8), he could have a preference for occupations in connection with power and money (management, business, finance, accounting, banking jobs, police, fireman, sports or industry...) if he was born on a 7th, 16th or 25th (or if he has a life Path Number of 7), he is more likely to choose one of the technical fields (engineering, mechanics or computers) or research; otherwise the paranormal could be very appealing given his strong intuition which could easily become clairvoyance (magnetism and healing...), or more commonly, medicine; and lastly, he could choose a career in fashion or creativity.
Discover others boys first names : Kian Kianoush Kiaran
*To note: :
It sometimes happens that two different first names have the same meaning. This has nothing surprising: both first names have the same figures of numerology. It is as in astrology: two persons belonging to the same sign present the same characteristic...
Names compatibility
Test the compatibility of your names to know if your love relation is lucky to succeed. Friendship, love or passion?
Discover fast what waits for you...
Verify now if your names are compatible!
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Your Name Horoscope !
Thanks to the numerology, we propose you daily a horoscope personalized for your first name. Love, money , Shape: discover what waits for you for today. In Bonus every day find your daily lucky figure .. Horoscope of the first names
Love :Couples: The complicity between the two of you will be reinforced. Singles: An admirer will make themselves known.
Money :You are trying to decide whether or not to make a property investment. Take your time.
Health:You won't see any results without some effort Kinkata.
Your Lucky number : 80


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First time here, so sorry if this isn't the right place to post this
I'm a huge fan of Rhun cosmetic wise, their armor is just so perfect to my eyes. I've seen a few mods implement Rhun like Blood in the West, The Last Days (though portrays them more barbaric and tribal rather than shiny gold armor), and a couple LotR mods that have Rhun in them for Total War installments. Beyond that, though, I can't seem to find any mods on them. Honestly I was looking for a preferrable third person mod, perhaps even a first person. In desperation, I'll even take appearances of Rhun in mods xD But yeah, I was curious if anyone had any info on LotR mods that had Rhun in them that fit the 1st/3rd person perspective style gameplay.
Thanks to those who reply


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A new treatment for neonatal diabetes
The optimal treatment for patients with KCNJ11 neonatal diabetes is high doses of sulphonylureas which enable patients to release insulin in response to raised blood glucose levels after a meal. The vast majority (>90%) of patients with neonatal diabetes caused by potassium channel mutations can be successfully treated with sulphonylurea tablets instead of insulin injections, leading to improvements in glycaemic control.
Reduction in Glycated Hemoglobin Levels Associated with Switching from Insulin to Sulfonylurea Therapy. From The New England Journal of Medicine, Pearson ER et al, Switching from Insulin to Oral Sulfonylureas in Patients with Diabetes Due to Kir6.2 Mutations, 355:467-477. Copyright © (2006) Massachusetts Medical Society. Reproduced with permission from Massachusetts Medical Society.
As you've already heard the KCNJ11 and ABCC8 genetic changes affect the Kir6.2 and SUR1 subunits of the potassium channel which provide the link between the sensing of glucose and the release of insulin from the pancreatic beta cell. Sulphonylureas bind to the channel to enable the pancreatic beta cell to respond by secreting insulin when food is eaten.
So confirming a genetic cause of Jack's condition also enabled him to transfer from insulin injections to sulphonylurea tablets, leading to improvements in his blood glucose measures. You can find more information about treating this rare condition based on our experience since 2004 with more than 400 patients worldwide on our Diabetes Genes website.
© University of Exeter


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Hapten-labeled nucleotide analogs for enzymatic incorporation, for indirect detection.
Please enter valid quantity
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This biotin labeled analog of guanosine triphosphate (GTP) is used for labeling RNA probes via in vitro transcription with various RNA polymerases. Biotin labeled RNA probes are used in a variety of molecular biology applications including in situ hybridization and gene expression microarrays. Biotin-labeled products may be detected with streptavidin conjugates. For the highest sensitivity in detection, we recommend using a streptavidin-HRP conjugate with tyramide signal amplification (TSA).
The number "11" in the compound name refers to the length of the linker arm between GTP and the label.
|Shipping Condition
TSA reduces exposure timein an imaging assay for PKCa. Protein kinase C alpha (PKCa) is associated with a wide variety of cellular processes including proliferation, adhesion and motility.
Nucleotide analogs are biologically active with a variety of DNA and/or RNA polymerases. Labeling methods such as: nick translation, random priming, polymerase chain reaction, 3'-end labeling, or transcription of RNA using SP6, T3, or T7 RNA polymerases may be used.


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Google Hits Its Q2 Numbers, and Wall Street Shrugs
For now, they seem okay with what they see. Quite often, companies that merely hit Wall Street estimates are punished, because the published estimates aren't the "real" estimates. But for now, GOOG is trading up a couple percent after hours.
Here, as always, is a "cheat sheet" from Citi analyst Mark Mahaney. Again, note that there are now multiple ways to view Google's performance. The most important one should be what Mahaney refers to as "core" Google — that is, Google minus Motorola.
Cost per click is down 16 percent, which is what Mahaney was expecting. We'll see if other investors are okay with the decline — in past quarters, analysts have spent a bunch of time harping on CPC.
Google hired a whopping 21,527 people in the last three months — but almost all of them are Motorola Mobility employees. Net those folks out and Larry Page ended up adding a much more modest 1,234 workers.
Don't look for Page on the upcoming call: Google has already warned that he is unlikely to show up, due to health problems. Google's IR page says the call will be hosted by Patrick Pichette, Nikesh Arora and Susan Wojcicki.
4:29 pm: Greetings! Just enjoying a couple minutes of pre-call music from the Google live feed. You can listen in for yourself here.
4:33 pm: Call's starting. Meanwhile, for people who care about the TV biz: Smart analyst Rich Greenfield says the DirecTV-Viacom standoff is over, or about to be.
4:33 pm: Here's Pichette, explaining that the Motorola deal means new reporting for Google. He also gets to say "stub period."
And this is the part where he reads results that Google has already distributed in its releases.
Google core biz doing well against "somewhat difficult" world climate, Pichette says.
4:41 pm: Now on to sales boss Nikesh Arora.
Want to talk about three themes: How big bets on digital advertising are working out, a look under the hood at search and some talk about enterprise.
Arora praises DoubleClick, the ad serving company it bought a few years ago which now serves as the base of its display business. That's the same deal that led Microsoft to pay $6 billion for aQuantive, a purchase that it wrote off a couple weeks ago, and which put a huge dent in Redmond's earnings today.
Time to boast about YouTube: People used to say YouTube was groping for a business model. "I think we can now declare we've found our model."
Will that include a boast about YouTube's revenues, costs, profits?
a lot of people liked our YouTube upfront …
So, no. No YouTube financial numbers. But! AdMob is working out well for us on the mobile front.
4:45 pm: Second theme: "the secret sauce of search advertising."
Our product teams work really hard — 72 improvements this quarter!
4:46 pm: Theme three: We're awesome at enterprise. A small but growing business that's going to be important. Five million businesses that have gone Google worldwide. "You can't fake a commitment to cloud computing."
4:48 pm: Now onto a world tour: U.S. and Canada steady. Spain not so great. Northern Europe pretty good.
4:49 pm: Meanwhile, analyst Mahaney weighs in with his analysis of the results: "Reasonably Strong Q2 Results…Noisily Positive."
Arora spending time discussing the winner of the Google Doodle contest. He's in second grade, I believe.
4:52 pm: On to product boss Susan Wojcicki.
Wojcicki says she plans to see the Dark Knight movie this weekend. And when she Googled the name of the movie, she discovered it was opening this weekend. So if you never, ever leave the house, listen to the radio, watch TV or surf any Web sites, Google can be very, very useful.
The point of the above anecdote was to show off the Google "knowledge graph" which translates into "the stuff on the right-hand side of the search results page."
Sorry, Wojcicki just announced a Google+ user number, but I didn't catch it. I'm sure it will be a number that many people will not believe and that Google will angrily defend.
Wojcicki continuing to list products the company has rolled out or improved during the last quarter, as she does every quarter. I wonder what analysts do during this part. An endorsement for the Google Glass demo with the skydivers.
4:59 pm: Pichette: We now have a Google+ IR page, too. Also, here's chief lawyer David Drummond.
Q: You said Motorola would be accretive. But it has pretty consistently lost money. How do you fix that? Also, what are the possibilities of Google voice search for mobile?
Pichette: We're psyched about Motorola. But we just got started. "Nothing really to announce right now. … we have to let them do their work, but I can tell you there's a palpable excitement at MMI." Also, if you took some of the one-time stuff and "accounting noise" out of the quarter, it's pretty good for the mobile side.
Wojcicki: We've invested in voice for a while. Jellybean OS allows you to ask questions with voice. A "really amazing technology that is really leading edge on that."
Q: More on Motorola accounting. How do you sort out purchase price — hard assets v. patents, goodwill, etc. Also, is the Motorola set-top box strategic for you?
Pichette: We break out some of this in the earnings already. As far as the home business: "We've just gotten to the place. And we're in the process of evaluating …" Be patient, please.
Q: On mobile, have you conducted a study on mobile on search query demand? Are mobile queries cannibalistic? Also, on YouTube, how do you give brand advertisers visibility on ROI?
Wojcicki: On cannibalization: We've spent a lot of time looking at mobile v. desktop. Complicated, but we think that mobile searches are "mostly incremental" — people search mobile on weekends, desktop during workdays.
Still looking into tablet searches, though.
Arora: For YouTube, direct marketers can see results pretty easily. For brand guys, it's more complicated. Trying "single-source panels" where we compare ROI to TV.
Q: Can you give us an update on Larry's health? And how's Chrome doing on iOS devices? Also, you're saying things like self-driving cars aren't big investments, but seems like maybe they are, especially with Google glasses.
Arora: "No more new news on Larry … but he continues to run the company and he's here and involved" in all the strategic decisions.
(Sorry, missed remainder of answers.)
Q: Seems like hiring Silicon Valley talent is getting more and more expensive. Please talk about that.
Pichette: "The Valley continues to be hot. It's a hotbed of innovation … we're delighted by our strategy." Good retention, recruitment.
Q: What are you seeing with mobile CPC trends? And with Nexus 7, can you talk about content acquisition for video and books?
Arora: Seeing tons of growth in mobile across the board. "Mobile is, right now, where search was in 1999."
In terms of content: "I think we've made a tremendous amount of headway in the content space … we're making progress across the board." (Translation: No answer.)
Q: About accounting for Nexus 7 costs.
Pichette: We treat it differently depending on whether we sell it direct or if it's through stores.
Q: Talk more about geographic mix, please. And a little about TAC, too.
A: (This is the part of the call where I normally imagine myself on a balloon ride and find it hard to track. This one even more snoozy than normal, but I'll try to stay. on. target.)
Q: (Filibuster, which includes references to CPC.)
Pichtte: I don't really want to talk about CPC, but I will. Have to talk about it every three months.
Q: Hey, remember when offers was a big deal? You were going to buy Groupon, right?
Wojcicki: Yup, important.
(Pretty sure there has been almost zero info disclosed today.)
(Slipped a bunch of questions.)
(This one, too.)
(And that one.)
Q: Want to tell us how big mobile search queries are? What about other mobile stats?
A: Nope.
Q: Can you talk about Google+ member growth? How's that going? How can you drive faster? Or should it be organic?
Wojcicki: Overall, we've been really pleased with the growth — 250 million Google+ customers. Remember that when you have Google+ you can share. And that Google+ is a "spine" across all of Google. (Basically a non-answer, too.)
Phew. Call's over.
Image: iStockphoto | maybefalse


text:
UConn beats Harvard 61-56 after fall from Top 25
STORRS >> Shabazz Napier scored 13 of his 18 points in the second half and UConn snapped a two-game losing streak with a 61-56 win Wednesday over Harvard.
Ryan Boatright added 14 points and DeAndre Daniels had 11 points and eight rebounds for the Huskies (12-3), who overcame a five-point halftime deficit to win their final non-conference game of the season.
Siyani Chambers had 21 points, including five 3-point baskets to lead Harvard (13-2), which lost for just the second time this season and the first time in 10 games.
Laurent Rivard added 13 points and Kyle Casey chipped in with 10 points and nine rebounds for the Crimson.
Harvard played the game without the team's star player, Wesley Saunders. Saunders, who was averaging just under 16 points per game had pregame issue with his left knee, and was held out as a precaution.
Harvard led for much of the first half, and 31-26 at halftime. But consecutive 3-pointers from Boatright and Daniels gave UConn a 37-34 lead.
Chambers tied it again with a 3-pointer before UConn used an 11-2 run to take their largest lead of the game at 48-39.
Another Chambers 3-pointer cut the UConn lead to 49-47.
But Napier took over from there. He hit a 3-pointer from the right corner and another from the left wing to give UConn a 55-47 lead with just 1:30 to play.
Rivard converted a four-point play to cut the lead to five points with just 35 seconds left, and made a 3-point play with 16 seconds left to cut the UConn lead to three.
Harvard got one final chance when Niels Giffey was called for traveling with 9 seconds left. But Daniels stole a pass and sealed the game with two foul shots.
It was an important win for the Huskies, who fell out of the Top 25 this week after losing their last two games to Houston and SMU on the road. UConn had dropped three of six after starting the season with 11 consecutive wins.
The Huskies led early in the game. But Harvard used a 12-0 run to turn a 10-4 deficit into a 16-10 lead, led by Casey who had six points during the spurt.
The Crimson held UConn without a field goal for more than 6 minutes.
The Huskies scored the next seven points, but trailed 24-20 after back-to-back 3-pointers from Chambers and Rivard.
The Huskies had 11 turnovers in the first 30 minutes, but just four in the second half. Chambers hit a jump shot from the foul line just before the halftime buzzer to send Harvard into the break with a 31-26 lead.
Harvard s best start since the 1945-46 season.
Their only other loss this season came at No. 15 Colorado.
The Crimson have just two winning streaks of 10 games or more in the history of the program. They won 10 straight in 1904-05, and 13 in a row in 1945-46.
UConn has now won 10 straight against Harvard, and 17 of the last 19 meetings with the Crimson. Harvard's last win came in 1972.


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