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Burrow, T., and M. B. Emeneau. A Dravidian etymological dictionary. 2nd ed. Oxford [Oxfordshire]: Clarendon Press, 1984.
Copyright © 1984 by Oxford University Press
No part of this publication may be stored, transmitted, retransmitted, lent, or reproduced in any form or medium without the permission of Oxford University Press.
This presentation of A Dravidian etymological dictionary allows readers to search for all of the information in the indexes to the ink-print edition. Consequently, the indexes and concordance have not been included as separate text.
A Dravidian etymological dictionary includes many uncommon diacritical marks. A Unicode font must be installed to display them properly. Information and instructions are available on the Font help page.
Data for this dictionary was most recently updated in January 2006.
Web presentation of this dictionary is funded in part by the U.S. Department of Education.

subset: commoncrawl


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DWTS Season 13 – Rumor Round Up, Part II
Okay, it's about that time again! Funny, I was thinking there hadn't been enough new rumors to cover since I did Part I – and realized that I have a poor sense of what happened when. 🙂 There have been quite a few!!
Remember in that first post when I said how fun this was and it's my favorite part of the season of blogging?? Well, that's still true, and I enjoy my what seems like daily DM sessions with Vogue as we try to figure out what to post and what to ignore…but I'm ready for Monday now. 🙂 I'm tired of reading parts of Twitter that I normally would avoid like the plague and I'm ready to start writing fresh Cheese. 🙂 Only a few more days till the announcement!! Yay. NOTE: Don't forget that I'm live blogging the announcement right here at PureDWTS. Once the announcement is made, I'm going to guess who got who (well, some of those are out in the open already 🙂 ) in a post that will likely be early Tuesday morning – get your guesses ready so you can add them in the comments. Wednesday morning we will post the official pairings and let the screams of "ringer" and whining and hand wringing begin!! 🙂 I'll go first…This is Maks' FOURTH either high profile or talented partner in a row!!! Heh. Just thought I would put that out there before people start bitching about Derek. 😀
On with the show…First up, those "rumors" that are pretty darn non-rumorish at this point:
Hope Solo – first it was a hint, then a tweet that sort of implied that she wasn't, then it was a tease, and then she kinda outed herself on twitter.
David Arquette – seen at dance studio with Kym Johnson.
For New Rumors that Seem Solid:
Ryan O'Neal – this one comes from ET, which makes it somewhat credible.
Kim Richards – I only believe this one because it just came out yesterday and it sounds like Celebuzz spotted her at a dance studio. We'll see. 🙂
Those Rumors that I Just Don't Believe, for a Variety of Reasons:
Jenna Jameson – she's a former porn star!! But she was following some pros…
Elisabetta Canalis – this came from E! News, who claim "many sources" are telling them Elizabetta is signing on. But this would be a new level of "WHO?" for most people, I think.
In the category of "Do DJs in Small Markets have any cred??":
Erica Durance – think this one might be serious wishful thinking. It came from a comment on a USA Today article referencing what he heard a DJ say. Convoluted enough for ya?? 🙂 Her people have since said it's false.
Henry Winkler – two different DJs tweeted about this one today and I don't know what to make of it. Hmmm…
Which rumors do I think might be true?? Well, besides Hope and David, I think the following are pretty solid:
Chynna Phyllips
Kristin Cavallari
Chaz Bono (TMZ just claimed he's in for sure. We said this days ago, hello?)
Kim Richards
Rob Kardashian
I have other thoughts, but these are all I'm willing to share right now. 🙂


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I've compiled a short list of some websites who provides shipping to anywhere in the world.I was searching for these kinda websites from quite some time & i've found some.These websites will come handy to all the people specially who don't live in USA & Canada.These websites also ship to US/Can but then there are lots of E-tailers for US or Canada like Newegg ,Zipzoomfly or many.But the main problem is for us (international customers) is that, most of the time we can't get a device in our country & we can't get it shipped from US/Canada if we don't have any relative or familiar person in the United States.So, for them & me these few websites may prove useful because these websites offer hardwares at USA rates & offers various methods of shipping to the whole world.
So, from now, if you can't get that Thermalright cooler or an OCZ memory or PSU in your country, you know where you'll need to go.There may be many more websites who provide international shipping but I found some of them are really quick,believable & offers more options in case of shipping.Some websites accepts Paypal also.
Here are those websites providing shipping worldwide.
1. Frys (Variety of products to choose from) :- http://shop2.outpost.com/
2. Sidewinder Computers ( Indiana, US based company selling mod & cooling stuff ) :- http://www.sidewindercomputers.com/
3. Memory Configurator( Ireland based company selling mostly memory related stuff ) :- http://www.memory-configurator.com/
4. ComputerGeeks( California, based company selling all geeky hot stuff ) :- http://www.geeks.com/
5. EXcaliberPC :- http://www.excaliberpc.com/
6. Compuvest :- http://www.compuvest.com/
7. USBGeek (All USB related geeky stuff ) :- http://www.usbgeek.com/
8. Modemod ( Singapore based company selling all modding stuff ) :- http://www.modemod.com.sg/shop/
9. FrozenCPU(All modding & cooling stuff ) :- http://www.frozencpu.com/
10. 47StPhoto ( Cameras, Lens, Memory Cards etc ) :- http://www.47stphoto.com/
11. Eparts & More :- http://www.epartsandmore.com/
12. Quiet PC :- http://www.quietpc.com/
13. Think Geek :- http://www.thinkgeek.com/
14. Performance-PCs :- http://www.performance-pcs.com/
15. Shop BLT (Best & fastest Customer support) :- http://www.shopblt.com/
16. Star Tech :- https://www.startech.com/
17. L-Com :- http://www.l-com.com/
18. National-Tech :- https://www.national-tech.com/
19. Crucial :- http://www.crucial.com/
20. Auzentech :- http://www.auzentech.com/
21. Petras Tech Shop :- http://www.petrastechshop.com/index.html
Websites offering International Shipping
Know of a great deal on the web or at a local retailer? Let your fellow members in on the secret!
Post Reply
3 posts • Page 1 of 1
Websites offering International Shipping
Last edited by sushrukh on Tue Nov 17, 2009 2:33 am, edited 1 time in total.
Re: Websites offering International Shipping
You can add Petra's Tech Shop to the list, they ship international and I found them to be reliable as well
Re: Websites offering International Shipping
Thank you.I've added that to my list.
Post Reply
3 posts • Page 1 of 1


text: Shop Our Categories Kushies Baby USA Online View cart Feeding Nursing Nursing Covers Burp Pads Nursing Pillows Nursing Pads SiliFeeding Lunch Essentials Bibs Tableware Sets CleanMats Nursery Hangers Sheets Toddler Crib Sheets Bassinet Sheets Blankets Playpen Sheets Waterproof Ben & Noa Linens Percale Flannel Jersey Pillow Cases Change Pad Covers Organic Bamboo Pillows Night Lights Bath & Change Bath Organic Skin Care Bath Toys Change Diapering Training Pants Swim Diapers Cloth Diapers Wet Bags Wear Apparel Boy Bodysuits - Boy One Piece - Boy Sets - Boy Tops - Boy Bottoms - Boy Accessories - Boy Girl Bodysuits - Girl One Piece - Girl Sets - Girl Tops - Girl Bottoms - Girl Accessories - Girl Neutral Bodysuits - Neutral One Piece - Neutral Sets - Neutral Tops - Neutral Bottoms - Neutral Accessories - Neutral Summer Rain Winter Accessories Gear Gifts Boy Girl Neutral For Mom Sale Masks Close Search Submit search $5 flat rate shipping on all orders. Nav Menu 2 Nav Menu 3 Nav Menu 4 Nav Menu 5 Nav Menu 6 Nav Menu 7 Nav Menu 8 Home > Bath & Change > Diapering > Cloth Diapers > UltraLite Diaper White Doodle Hearts Price: $13.99 -$15.99 Product code: UL2000-3000-77 Infant / 10-22 lbs Toddler / 22-45 lbs Qty: Description Our Ultra-Lite "All-In-One" form-fitted washable cloth diapers are an environmentally friendly alternative to disposable diapers yet just as easy to use! Featuring 6 layers of 100% cotton-flannel with a special absorbent soaker layer inside, and a lightweight waterproof shell on the outside. The hook and loop closure system and the extended tabs provide optimum adjustability for a snug fit. Our patented, built in-flap can be folded up for boys or down for girls for extra absorbency where they need it most. Better for your baby, better for the environment and better for your pocket book!Infant / 10-22lbs - $14.49Toddler / 22-45lbs - $17.49 YOU MAY ALSO LIKE Taffeta Waterproof Diaper Wrap | Aqua Flushable/Biodegradable Diaper Liners Taffeta Waterproof Diaper Wrap | White Elephants UltraLite Diaper Grey Chevron Sale: $6.98 Price: $10.99 Price: $9.99 Price: $13.99 -$15.99 Taffeta Waterproof Diaper Wrap | White Safari UltraLite Diaper Blue Whales Flat Diapers White Taffeta Waterproof Diaper Wrap | Blue Whales Price: $9.99 Price: $13.99 -$15.99 Price: $23.99 Price: $9.99 Share your knowledge of this product. Be the first to write a review »


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After more than four months of testimony, the Michael Jackson wrongful death case could finally go to the jury later this month.
Court clerk Neli Raya said she expects the case willl be handed to the jury in about 2 1/2 weeks.
Marvin Putnam, attorney for AEG Live, has said he expects to rest his case next Friday at the latest. Then each side could call rebuttal witnesses, and attorneys could argue over the instructions the judge will give the 12 jurors who have sat through the marathon.
While jurors have heard from financial experts, AEG executives, doctors and Jackson family members, none of the celebrities on the attorneys witness lists — Prince, Spike Lee, Quincy Jones and Diana Ross among them — have been called to testify.
The case revolves around the question of who controlled Dr. Conrad Murray, the cardiologist who administered the fatal dose of the anesthetic propofol to Jackson at the singer's rented Holmby Hills home on June 25, 2009.
Jackson was preparing for a 50-concert comeback in London that was being promoted and produced by AEG. Murray was convicted of involuntary manslaughter and is serving a jail sentence.
The Jacksons say that AEG negligently hired and supervised Murray, while AEG says the singer hired him and that any money the entertainment firm was supposed to pay him was an advance.
Courtesy of Los Angeles Times


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The John Main Seminar is a major event of the World Community hosted annually in different countries. In 2011 it was led by the English Dominican Timothy Radcliffe and hosted by the Irish Christian Meditation Community. The pre-Seminar retreat was led by Fr Laurence on "Fruits of Crisis".
For more information on the Seminar theme and the speaker visit: www.jms11.com.
320 meditators from 22 countries participated. Below, there are comments from some of the participants and the gallery of the seminar. Medio Media will be publishing the talks of the seminar shortly.
- Read more about the seminar at page 7 of the October WCCM Quarterly Newsletter
- See the video of Timothy Radcliffe speaking about the JM Seminar HERE
- See the John Main Seminar 2011 Picture Gallery HERE
- See the John Main Seminar 2011 Videos on our YouTube Channel HERE
- Read the sermon by Abbot Patrick Hederman, of Glenstal Abbey, at the closing mass of the John Main Seminar HERE
Add your comments about the Seminar HERE
Thanks for the conference
Wonderful experience thank you to all concerned, Ursula & kieran Murphy
The seminar is also an experience of joy. Meditating together and entering into the silence with people from around the world. It is entering into the reality of the body of Christ, not as a theory but as a reality. Thank you so much for this expiernce of what chuch can be.


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Psoriasis is a common skin condition that can affect anyone, although it's more common in people between the ages of 15 and 35, according to the National Psoriasis Foundation. If you have psoriasis, your skin cells grow faster than normal.
The body naturally develops new skin cells every month to replace skin that sheds or flakes off. With psoriasis, new skin cells form within days rather than weeks. This rapid growth causes dead skin cells to accumulate on the skin's surface, resulting in thick patches of red, dry, and itchy skin.
Psoriasis is a chronic condition, but symptoms may improve over time.
Types of Psoriasis
Psoriasis can occur on the scalp, nails, and joints. In the United States, about 7.5 million people have psoriasis, according to the American Academy of Dermatology (AAD). The five types of psoriasis include the following.
Plaque Psoriasis
This common form of psoriasis causes raised, red patches on the skin. Skin patches can be itchy and painful.
Guttate Psoriasis
This type of psoriasis can start in childhood or young adulthood.
Inverse Psoriasis
This type of psoriasis causes red lesions in body folds.
Pustular Psoriasis
This type causes white blisters and red skin.
Erythrodermic Psoriasis
This rare inflammatory type of psoriasis can develop over the entire body. Symptoms include widespread redness, pain, and severe itching.
Psoriasis Causes
The exact cause of psoriasis is unknown. However, it's believed that your immune system and genes may contribute to the condition. Your body's T-cells normally fight viruses and bacteria. In psoriasis, they may start to attack healthy skin cells. Your body increases its production of new skin cells in response to this attack. These new skin cells move to the outer layer of your skin before dead skin cells shed, triggering scaly skin patches.
Psoriasis is not contagious. However, the condition may run in families. Risk factors for psoriasis include:
- family history of the condition
- having a viral or bacterial infection
- obesity
- smoking
- uncontrolled stress
- use of certain medications, such as those used to treat bipolar disorder and high blood pressure
Psoriasis Diagnosis and Tests
Psoriasis can mimic other skin conditions like ringworm and dermatitis. You'll need to schedule an appointment with your doctor to confirm a diagnosis. About 95 percent of the time, doctors can diagnose psoriasis just by looking at your skin, says the National Psoriasis Foundation. Doctors sometimes need to perform a skin biopsy to rule out other skin conditions. During a biopsy, your doctor removes a piece of skin tissue and exams it under a microscope.
Psoriasis Treatment
If you're diagnosed with psoriasis, your doctor may refer you to a dermatologist. A dermatologist is a doctor who specializes in skin diseases.
There's no cure for psoriasis. But with treatment, you can reduce inflammation and skin irritation. Some treatment options are described below.
Topical Therapy
Your doctor may prescribe creams or ointments for your skin or scalp. These can include:
- topical corticosteroids
- vitamin D analogues
- topical retinoids
- salicylic acid
- moisturizers
Light Therapy
This therapy exposes skin to natural or artificial ultraviolet light under medical supervision. This treatment helps slow the growth of new skin cells.
If your psoriasis is severe or doesn't respond to other treatments, your doctor may prescribe medications to suppress your immune system.
Along with treatments recommended by your doctor, you can take other steps to reduce symptoms. Oatmeal baths may soothe irritated, red skin. Applying moisturizer to dry, itchy skin immediately after a bath or shower can also reduce flare-ups. Psoriasis may also improve if you limit alcohol consumption and learn ways to manage stress. Talk to your doctor about your treatment options.
Psoriasis Complications
Psoriasis can increase your risk for other illnesses. Some people develop psoriatic arthritis, which can cause severe joint damage. You'll need to see a rheumatologist for treatment if your dermatologist suspects this type of psoriasis.
You also have a greater risk of developing type 2 diabetes and cardiovascular disease. Other possible complications of psoriasis include an increased risk for:
- high blood pressure
- celiac disease and Crohn's disease
- Parkinson's disease
- kidney disease
Because psoriasis can develop anywhere on the body and become a widespread problem, you may also deal with periods of low self-esteem, social isolation, and depression.
Psoriasis Prevention
There's no way to prevent psoriasis. You can reduce flare-ups by following your doctor's treatment plan and recommendations and by avoiding common triggers like stress and smoking.
Psoriasis is a lifelong condition but it doesn't have to negatively impact the quality of your life. Talk to your doctor if you have symptoms of psoriasis or if the condition causes depression or mood problems.
REF: Healthline.com


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Bayou Bar
The Bayou Bar, where the New Orleans Saints football franchise was christened in 1966, offers a casual tavern-style ambiance warmed by exposed wood. Once a drinking den for both Sinatra and Capote, The Bayou Bar features an extensive whiskey and beer list. Uptown locals and visitors alike have the option to hang out at the rollicking Steinway piano, the intimate tables or the shotgun bar.
Temporarily closed until further notice.


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Ct. voter database plagued by glitches
For the second time in two weeks, a "stress test" conducted on Connecticut's centralized voter registration database Wednesday exposed serious glitches in the system.
Election officials said they endured lengthy wait times to print out voter lists or simply to verify who is eligible to cast ballots next month in a host of marquee races, including the presidency.
Some registrars of voters eventually gave up, choosing to try again during off-peak periods.
The Secretary of the State's Office acknowledged it has a problem on its hands and said it will convene a special meeting Thursday with the state's technology team. The agency can least afford any mistakes after a ballot shortage in Bridgeport two years ago cast a dark cloud over the gubernatorial election won by Democrat Dannel P. Malloy over Republican Tom Foley by 6,500 votes.
About 100 of 169 total cities and towns in the state participated in the latest drill, with registrars all logging on at the same time and trying to print out rosters of voters for each polling place in their municipality.
A similar stress test was performed Sept. 26, with what registrars described as abominable results that cast doubts about whether the system can handle the rigors of the upcoming election.
"So the portion of the program that produced poll books slowed to a crawl," said Fred DeCaro III, Greenwich's Republican registrar. "It might normally take less than a minute to generate. And we had times upward of 20 minutes for a single polling place."
Judi Beaudreau, the Democratic registrar in Vernon, encountered similar problems both times.
"I wasn't able to get in until later. Once I did get in, I wasn't able to process for about 10 minutes," said Beaudreau, a former president of the Registrars of Voters Association of Connecticut.
The timetable for printing out voter lists, which usually takes place a week before the election, is set by state law. Supplemental lists are printed out the day before the election.
Av Harris, a spokesman for Secretary of the State Denise Merrill, who came into office at the start of 2011, explained that the centralized voter database used to be on its own mainframe but was integrated about a year ago into the mainframe used the following state departments and agencies: Motor Vehicles, Social Services, Children and Families, Voter and Business Registration, State Police, Correction, Retirement and several others.
"This needs to work, not only on Election Day, but in preparation for Election Day," Harris said. "We are aware of the fact that there are load capacity issues. The importance that this system works is critical."
Election officials will troubleshoot the problem Thursday morning with representatives of the state Department of Administrative Services Bureau of Enterprise Systems and Technology, which said in an internal memo obtained by Hearst Connecticut Newspapers that it upgraded the mainframe on Sept. 30 to provide 21 percent more capacity.
"This system has been approaching and has been reaching its full capacity over the last several months," Mark Raymond, the state's chief information officer wrote in that memo. "Despite our efforts to manage processing needs, the demand has outpaced the available capacity."
Beaudreau is optimistic the kinks will get worked out.
"I don't think that the secretary of the state wants this on her head if it does fail, so you know darn well that it's going to be working well on Election Day," she said.
firstname.lastname@example.com; 203-625-4436; http://twitter.com/gettinviggy


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California mulls how to regulate 'driverless cars'
LOS ANGELES - California's Department of Motor Vehicles is wading into the complex question of how to regulate the use of cars that rely on computers — not people — to drive them.
Once the stuff of science fiction, "Driverless cars" could be commercially available by decade's end.
On Tuesday, the DMV is hearing ideas on how to integrate the cars onto public roads. Questions range from data privacy and security — to whether a person will have to be in the driver's seat at all.
The DMV already has drafted rules governing how companies can test the technology. Google had been testing on highways and in neighborhoods well before the Legislature decided to regulate.


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Source: Raytheon Company
Monday, June 17, 2013 01:00 PM IST (07:30 AM GMT)
Editors: General: Consumer interest, People; Business: Advertising, PR & marketing, Business services, Defence & security, Information technology; Technology
Javelin Weapon System Goes 5-for-5 in Yudh Abhyas Trials
Indian Army gunners fire direct hits in first-time use
New Delhi, Delhi, India, Monday, June 17, 2013 — (Business Wire India)
As part of the Indian Army and U.S. Army Yudh Abhyas joint exercise, the Raytheon Company (NYSE: RTN) and Lockheed Martin Corporation (NYSE: LMT) Javelin Weapon System proved flawless performance as an anti-tank guided missile.
Five Javelin missiles fired from the command launch unit achieved five direct-hits. The Javelins were fired by two U.S. Army gunners from the 82nd Airborne Division and three Indian Army gunners.
"In recent years, Indian and U.S. gunners have fired a total of 16 Javelin missiles with 16 direct-hits in multiple Yudh Abhyas joint exercises; the results speak for themselves," said Duane Gooden, president of the Javelin Joint Venture and director of the Raytheon Javelin program. "These warfighters experienced reliability and user friendliness first hand."
Javelin is the world's only shoulder launched fire-and-forget missile system that is combat proven and capable of defeating any armored vehicle.
"Javelin provides a key opportunity to strengthen the U.S. and India relationship, and the Javelin Joint Venture regards it as a high priority. We are prepared to comply with India's requirement for major defense procurements," said Barry James, vice president of the Javelin Joint Venture and Javelin program director at Lockheed Martin.
About Javelin
Javelin is the world's most versatile and lethal one-man-portable, anti-tank, guided missile and surveillance weapon system. It is made by the Javelin Joint Venture, a partnership between Raytheon Company and Lockheed Martin. Javelin has been adopted by international armed forces around the world. It is currently fielded with the U.S. Army and U.S. Marine Corps and has also been approved for foreign military sales to 13 nations.
About Lockheed Martin Corporation
Headquartered in Bethesda, Md., Lockheed Martin is a global security and aerospace company that employs about 118,000 people worldwide and is principally engaged in the research, design, development, manufacture, integration and sustainment of advanced technology systems, products and services. The Corporation's net sales for 2012 were $47.2 billion. For additional information, visit our website: http://www.lockheedmartin.com.
About Raytheon
Raytheon Company, with 2012 sales of $24 billion and 68,000 employees worldwide, is a technology and innovation leader specializing in defense, security and civil markets throughout the world. With a history of innovation spanning 91 years, Raytheon provides state-of-the-art electronics, mission systems integration and other capabilities in the areas of sensing; effects; and command, control, communications and intelligence systems; as well as a broad range of mission support services. Raytheon is headquartered in Waltham, Mass. For more about Raytheon, visit us at www.raytheon.com and follow us on Twitter @raytheon.
For press backgrounder on Raytheon Company click here
Media contact details
John B. Patterson – Paris,
Raytheon Company,
Jaclyn Gutmann – Tucson,
Raytheon Company,
Abhishek Puri – India,
IPAN H+K Strategies,
+91 9810204659,
Melissa Hilliard,
Lockheed Martin Corporation,
Submit your press release at http://www.businesswireindia.com


text: It's got a three-year warranty, dummy On The Editor's Desk By Martha Entwistle Updated Fri December 7, 2007 Sorry, but I can't help myself. Here's a press release I received just now: A new dummy dome has been launched by Bosch Security Systems as part of its FlexiDome camera range. The dummy is intended for use in applications where multiple, working models may already be installed, but where further deterrents may be desired. The product resembles the FlexiDome VF and is delivered, ready to install, with a Surface Mount Box. Each product has a three-year warranty. Sweet! A three-year warranty on a dummy dome. I mean, is there a chance it could break in three years? What would happen? the words, "I am a fake camera," appear on the outside glass?


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Our 3 HP Plug and Play Spindle / VFD System is preconfigured to run with any of our CNC Electronics Systems and Kits.
Our current CRP800 Plug and Play Electronics Systems (Plug and Play NEMA 23 CNC Control System and Plug and Play NEMA 34 CNC Control System) are "Spindle Ready" and require no additional components to work with this Spindle / VFD system.
Compatibility options which include additional components for integrating our Spindle / VFD system with our previous CNC electronics systems, or with DIY CNC electronics are also available.
Please refer to the appropriate guide below for your electronics. If you are unsure which electronics package you have, our systems can be identified by the following:


text: Whether you're working from home, streaming media online or gaming, USB adapters are must-have accessories. Here at BT Shop, we stock a diverse range of adapters. If you're looking for quick and simple connectivity solutions, BT Shop has everything you need - including adapters. We stock adapters from the leading brands in the industry - including well-known and well-trusted names such as StarTech and C2G. Find the adapters you need today - take a look at the full BT Shop adapter range.


text:
The North Face Redbox T-Shirt in White and Stickerbomb. Exclusive to Footasylum. Never stop exploring thanks to this short sleeve, crew neck tee from outdoor experts, The North Face. Additional features include logo to chest and large print to back.
Fabric: This Product is 100% cotton.
Product Care: Machine Wash at 30C. Do not tumble dry.
We guarantee to refund or exchange any item you're not completely happy with, providing you return it to us in an unused and sellable condition within 28 days of the date on your receipt.
To make it even easier, any returns made via the Asda2You or Collect+ service are now free of charge. We aim to process all returns within 7 days of us receiving the goods back in our warehouse. To avoid delays please make sure that you fill out your returns form in full before sending your items back to us.More information on returns...


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Listen to free music played by annnavarro
Blip.fm is internet radio made social. It's easy to search for, play, and discover free music recommended by real people. Join today to create your own free station and start listening to @annnavarro.
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text:
Grand Theft Auto 5 E3 2014 Trailer: Coming to PlayStation 4
During Sony's E3 2014 press conference, it was revealed that Grand Theft Auto V will be coming to PlayStation 4 in the fall.
A remastered version of GTA V for the next gen consoles has been rumored for quite some time. It's also expected that GTA V will also be coming to Xbox One as well.
And there was good news for people who have put in considerable hours into the PS3 or Xbox 360 versions of Grand Theft Auto V: players will be able to transfer their save progress to the remastered version. Now they can continue their adventures with even better visuals.
GTA V was released on September 17, 2013 for PS3 and Xbox 360 and sold 11 million copies within the game's first 24 hours. Look forward to seeing it on PlayStation 4 in Fall 2014.


text:
xn----2hckc5bpef6bv.net has expired and is available to register.
Domain Name: XN----2HCKC5BPEF6BV.NET Registry Domain ID: 2094109229_DOMAIN_NET-VRSN Registrar WHOIS Server: whois.name.com Registrar URL: http://www.name.com Updated Date: 2017-01-30T13:42:51Z Creation Date: 2017-01-30T13:42:51Z Registrar Registration Expiration Date: 2018-01-30T13:42:51Z Registrar: Name.com, Inc. Registrar IANA ID: 625 Reseller: Domain Status: addPeriod Domain Status: clientTransferProhibited Registry Registrant ID: Registrant Name: Whois Agent Registrant Organization: Whois Privacy Protection Service, Inc. Registrant Street: PO Box 639 Registrant City: Kirkland Registrant State/Province: WA Registrant Postal Code: 98083 Registrant Country: US Registrant Phone: +1 4252740657 Registrant Fax: +1 4259744730 Registrant Email: firstname.lastname@example.com Registry Admin ID: Admin Name: Whois Agent Admin Organization: Whois Privacy Protection Service, Inc. Admin Street: PO Box 639 Admin City: Kirkland Admin State/Province: WA Admin Postal Code: 98083 Admin Country: US Admin Phone: +1 4252740657 Admin Fax: +1 4259744730 Admin Email: firstname.lastname@example.com Registry Tech ID: Tech Name: Whois Agent Tech Organization: Whois Privacy Protection Service, Inc. Tech Street: PO Box 639 Tech City: Kirkland Tech State/Province: WA Tech Postal Code: 98083 Tech Country: US Tech Phone: +1 4252740657 Tech Fax: +1 4259744730 Tech Email: email@example.com Name Server: dns.site5.com Name Server: dns2.site5.com DNSSEC: Unsigned Delegation Registrar Abuse Contact Email: firstname.lastname@example.com Registrar Abuse Contact Phone: +1 7203101849 URL of the ICANN WHOIS Data Problem Reporting System: http://wdprs.internic.net/>>> Last update of WHOIS database: 2017-01-30T23:37:32-07:00 <<< The Data in the Name.com, Inc. WHOIS database is provided by Name.com, Inc. for information purposes, and to assist persons in obtaining information about or related to a domain name registration record. Name.com, Inc. does not guarantee its accuracy. By submitting a WHOIS query, you agree that you will use this Data only for lawful purposes and that, under no circumstances will you use this Data to: (1) allow, enable, or otherwise support the transmission of mass unsolicited, commercial advertising or solicitations via e-mail (spam); or (2) enable high volume, automated, electronic processes that apply to Name.com, Inc. (or its systems). Name.com, Inc. reserves the right to modify these terms at any time. By submitting this query, you agree to abide by this policy.


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A Canadian who adorned his request for a free phone with a sketch of a dragon, and received a kangaroo in response, has now been rewarded with a custom S III as Samsung spots some good PR.
The posting on Samsung Canada's Facebook Wall asked for a free handset and offered the sketch as payment. Samsung Canada wittily responded with a sketch of a kangaroo on a unicycle, to the delight of the Reddit crowd, who elevated the story to such an extent that Samsung Canada has now supplied the requested handset as well as customising it with the aforementioned sketch.
The lucky chap has more images and details on his own Facebook stream
Some were dubious about the idea that a straight-laced corporation would be so impressed with a crudely drawn dragon that it would sketch a unicycling marsupial, but the response is far from unprecedented, even if the upgrade to a physical handset takes the gratitude up a notch.
It's easy to forget that large companies are comprised of small people who have just as much humour and sense of whimsy as the rest of us, from the legendary single cornflake (reportedly returned by Kellogg's in exchange for a burnt cornflake sent back under guarantee) to O2's deadpan responses to tweeted obscenity during its network outage, even M&S has been known respond with a comedy dinosaur in occasion.
Mostly such responses go unnoticed, perhaps raising a smile and providing some dinner party conversation, but now we have the internet everything can be shared and every whim exploited to maximum effect.
So Shane Bennett gets himself a unique Galaxy S III, and Samsung Canada's Facebook page becomes awash with badly drawn wildlife, but while one can hardly knock Samsung for making most out of the unexpected publicity one has to wonder how long it will be before PR outfits around the world are pitching whimsy as the next big thing. ®


text:
Walters accepts designation to Minors
ST. PETERSBURG -- Right-hander P.J. Walters has decided to stay in the Twins organization, accepting an outright assignment to Triple-A Rochester on Monday after being designated for assignment last Thursday.
Walters, 2-5 with a 5.95 ERA in eight starts for Minnesota this season, cleared waivers and had the option to become a free agent, but he instead chose to go back to Triple-A with the hope of being called up to rejoin the Twins at some point this season.
"He had a lot of good things to say about the way he was treated and how he has been treated over the two years. Wanted to stay with the organization," assistant general manager Rob Antony said. "He thought about it, and obviously he has the questions that anybody would ask. 'What's the situation? Do you think I have a chance to come back up or are you guys going to go young and bring up some of the younger guys?'
"I said there's no crystal ball, there's no guarantees, but go down there, get an opportunity to pitch, and if you're the guy, just like earlier this year, you might get a chance to come back up."
Walters will report to Rochester on Tuesday, and Antony said he hopes to make a start before the club's All-Star break from July 15-17. The 28-year-old has spent parts of five seasons in the Majors, posting a 6-10 record and 6.28 ERA in his career.
"There's a couple guys that are pitching fairly well down [in the Minors] right now that I would say probably would be ahead of him if we had to make a move tomorrow. But we'll just send him out," Antony said. "We've got some guys that are doing all right down there."
Manager Ron Gardenhire said Walters is "not necessarily" buried so far down on the Twins' depth chart that he won't get called up again. As Gardenhire put it, "We always go with who's throwing the best," should the need for a spot starter arise.
"We were disappointed when we had to make the move in the first place, because we like the guy an awful lot," Gardenhire said. "As we told him, 'We know we've got to do this. Hopefully you'll make it through for our benefit and you would accept. We would love to keep you.'
"I think he knows he'll get a chance again. We've given him the opportunity a couple times. We like him, and we were hoping it would work out for us that we got to keep him. And fortunately for us, he wanted to stay. We're happy about that."


text:
Research Area E
Systematic analysis of the binding behaviourof UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads
Systematic analysis of the binding behaviourof UHRF1 towards different methyl- and carboxylcytosine modification patterns at CpG dyads
Excursion of the CIPSM Integrated Graduate Forum to the Bayer AG as part of the lecture on Innovations Management of Alumnus Bayer AG Board of Management Member Wolfgang Plischke.
NAIL-MS reveals the repair of 2-methylthiocytidine by AlkB in E. coli
TLR8 Is a Sensor of RNase T2 Degradation Products
Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans
CIPSM Scientific Oktoberfest 2019
Richtfest bei unserem Institut für Chemische Epigenetik ICEM
CIPSM speaker Prof. Thomas Carell was elected to the BASF supervisory board
Characterization of a novel cytochrome cGJ as the electron acceptor of XoxF-MDH in the thermoacidophilic methanotroph Methylacidiphilum fumariolicum SolV
A network of chaperones prevents and detects failures in membrane protein lipid bilayer integration
Impact of the lanthanide contraction on the activity of a lanthanide-dependent methanol dehydrogenase – a kinetic and DFT study
Direct evidence for hula twist and single-bond rotation photoproducts
Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression
Transmission of Unidirectional Molecular Motor Rotation to a Remote Biaryl Axis
ProteomeTools: Systematic characterization of 21 post-translational protein modifications by LC-MS/MS using synthetic peptides
Chemo-enzymatic Total Synthesis of Oxosorbicillinol, Sorrentanone, Rezishanones B and C, Sorbicatechol A, Bisvertinolone, and (+)-Epoxysorbicillinol
Natural Product Potential of the Genus Nocardiopsis
Indigoid Photoswitches: Visible Light Responsive Molecular Tools
Synthesis of Fluorinated Leishmania Cap Trisaccharides for Diagnostic Tool and Vaccine Development
Photoisomerization of Mono‐Arylated Indigo and Water‐Induced Acceleration of Thermal cis‐to‐trans Isomerization
Simultaneous complementary photoswitching of hemithioindigo tweezers for dynamic guest relocalization
Baubeginn unseres Institutes für Chemische Epigenetik ICEM
Complete Mechanism of Hemithioindigo Motor Rotation
Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential
Transforming hemithioindigo from a two-way to a one-way molecular photoswitch by isolation in the gas phase
Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins
A Pericyclic Reaction Cascade in Leporin Biosynthesis
Time-resolved infrared studies of the unfolding of a light triggered b-hairpin peptide
Conditional and Reversible Activation of Class A and B G Protein- Coupled Receptors Using Tethered Pharmacology
Wet-dry cycles enable the parallel origin of canonical and non-canonical nucleosides by continuous synthesis
A sulfoxide-based isobaric labelling reagent for accurate quantitative mass spectrometry
Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase
Bap (Sil1) regulates the molecular chaperone BiP by coupling release of nucleotide and substrate
The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity
Synthesis of Double-Bond-Substituted Hemithioindigo Photoswitches
A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug‐Resistant Staphylococcus aureus
The target landscape of clinical kinase drugs
5-Formylcytosine to cytosine conversion by C–C bond cleavage in vivo
Direct Observation of Hemithioindigo-Motor Unidirectionality
Quantitative chemoproteomic profiling reveals multiple target interactions of spongiolactone derivatives in leukemia cells
Pharmacoproteomic characterisation of human colon and rectal cancer
Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy
Expanding the Structural Space of Ribosomal Peptides: Autocatalytic N‐Methylation in Omphalotin Biosynthesis
Structural Basis for EarP-Mediated Arginine Glycosylation of Translation Elongation Factor EF-P
Hemiindigo: Highly Bistable Photoswitching at the Biooptical Window
Rational Design of an Anticalin-Type Sugar-Binding Protein Using a Genetically Encoded Boronate Side Chain
An amino acid domino effect orchestrates ClpP's conformational states
PROCAL: A Set of 40 Peptide Standards for Retention Time Indexing, Column Performance Monitoring, and Collision Energy Calibration
Quantitative Proteomics for the Comprehensive Analysis of Stress Responses of Lactobacillus paracasei subsp. paracasei F19
A chemical compound inhibiting the Aha1-Hsp90 chaperone complex
Tight Molecular Recognition of Benzo[a]pyrene by a High‐Affinity Antibody
Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening
Stereoselective Total Synthesis of Bisorbicillinoid Natural Products by Enzymatic Oxidative Dearomatization/Dimerization
Trimodal Mixed Mode Chromatography That Enables Efficient Offline Two-Dimensional Peptide Fractionation for Proteome Analysis
Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ
5-Formyl- and 5-Carboxydeoxycytidines Do Not Cause Accumulation of Harmful Repair Intermediates in Stem Cells
Wissenschaftsrat gibt grünes Licht für den auf dem CIPSM basierenden Forschungsbau – chemische Epigenetik (ICEM)
Multivalent binding of PWWP2A to H2A.Z regulates mitosis and neural crest differentiation
Chemoproteomics‐Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors
Annotation of the Domestic Pig Genome by Quantitative Proteogenomics
Structural Insights into the Recognition of N2-Aryl- and C8-Aryl DNA Lesions by the Repair Protein XPA/Rad14
Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ
Two serines in the distal C-terminus of the human ß1-adrenoceptor determine ß-arrestin2 recruitment
Surface topology affects wetting behavior of Bacillus subtilis biofilms
Quantitative LC–MS Provides No Evidence for m6dA or m4dC in the Genome of Mouse Embryonic Stem Cells and Tissues
Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides
Chemical Probes Unravel an Antimicrobial Defense Response Triggered by Binding of the Human Opioid Dynorphin to a Bacterial Sensor Kinase
Bistable Photoswitching of Hemithioindigo with Green and Red Light: Entry Point to Advanced Molecular Digital Information Processing
Ingredients to TICT Formation in Donor Substituted Hemithioindigo
Novel Monoclonal Antibodies Recognizing Human Prostate‐Specific Membrane Antigen (PSMA) as Research and Theranostic Tools
The microstructure and micromechanics of the tendon–bone insertion
Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis
Quantitative Map of β-Lactone-Induced Virulence Regulation
Building ProteomeTools based on a complete synthetic human proteome
Biocatalytic Total Synthesis of Ikarugamycin
Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone
Students of the Ernst Mach Gymnasium came to CIPSM.
Proteomics reveals a new DNA repair factor involved in DNA damage signaling
2′-(R)-Fluorinated mC, hmC, fC and caC triphosphates are substrates for DNA polymerases and TET-enzymes
Synthesis of ramariolide natural products and discovery of their targets in mycobacteria
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells
Insights into ClpXP proteolysis: Heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes
Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β
Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response
Aligning, analyzing, and visualizing sequences for antibody engineering: Automated recognition of immunoglobulin variable region features
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs
Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs
Photocontrol of Polar Aromatic Interactions by a Bis-Hemithioindigo Based Helical Receptor
Activation of the ATR kinase by the RPA-binding protein ETAA1
Expression and purification of EPHA2 tyrosine kinase domain for crystallographic and NMR studies
Self-Assembled Palladium and Platinum Coordination Cages: Photophysical Studies and Anticancer Activity
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria
A bead-based western for high-throughput cellular signal transduction analyses
Comparison of enzymatic properties and small molecule inhibition of γ–glutamyltranspeptidases from pathogenic and commensal bacteria
Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex
Site-Specific Isotope-Labeling of Inosine Phosphoramidites and NMR Analysis of an Inosine-Containing RNA Duplex
PASylated Coversin, a C5-Specific Complement Inhibitor with Extended Pharmacokinetics, Shows Enhanced Anti-Hemolytic Activity in Vitro
Mechanistic analysis of aliphatic β-lactones in Vibrio harveyi reveals a quorum sensing independent mode of action
Fusion of an alcohol dehydrogenase with an aminotransferase using a PAS linker to improve coupled enzymatic alcohol-to-amine conversion
Twisted Hemithioindigo Photoswitches: Solvent Polarity Determines the Type of Light-Induced Rotations
5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites
Synthesis of (R)-Configured 2′-Fluorinated mC, hmC, fC, and caC Phosphoramidites and Oligonucleotides
Tumour hypoxia causes DNA hypermethylation by reducing TET activity
p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1
DNA hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy
Anticalins directed against vascular endothelial growth factor receptor 3 (VEGFR-3) with picomolar affinities show potential for medical therapy and in vivo imaging
Structural Basis for Bulky-Adduct DNA-Lesion Recognition by the Nucleotide Excision Repair Protein Rad14
Tumor uptake of anti-CD20 Fabs depends on tumor perfusion
BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP
One-Pot Synthesis of Substituted Trifluoromethylated 2,3-Dihydro-1H-imidazoles
Synthesis of a Fluorinated Sialophorin Hexasaccharide–Threonine Conjugate for Fmoc Solid-Phase Glycopeptide Synthesis
Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity
Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation
ANTICALIgN: visualizing, editing and analyzing combined nucleotide and amino acid sequence alignments for combinatorial protein engineering
A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway
MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome
High-affinity Anticalins with aggregation-blocking activity directed against the Alzheimer β-amyloid peptide
Structural basis for cellulose binding by the type A carbohydrate-binding module 64 of Spirochaeta thermophila
Active DNA demethylation at enhancers during the vertebrate phylotypic period
Genetically designed biomolecular capping system for mesoporous silica nanoparticles enables receptor-mediated cell uptake and controlled drug release
Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores
Molecular mechanisms of xeroderma pigmentosum (XP) proteins
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors
Convenient Access to Di- and Trifluoroethylamines for Lead Structure Research
One-Pot Synthesis of Functionalized β-Fluoroalkylated Mannich- Type Products from N-Aryl N,O-Acetals
Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics
Sequential Inactivation of Gliotoxin by the S-Methyltransferase TmtA
Selection and characterization of Anticalins targeting human prostate-specific membrane antigen (PSMA)
Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds
An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Season's Greetings and Best Wishes for a Happy New Year 2016 from CIPSM
moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
Optical Control of Insulin Secretion Using an Incretin Switch
Extending Polyketide Structural Diversity by Using Engineered Carboxylase/Reductase Enzymes
UV-Induced Charge Transfer States in DNA Promote Sequence Selective Self-Repair
Fimbrolide Natural Products Disrupt Bioluminescence of Vibrio By Targeting Autoinducer Biosynthesis and Luciferase Activity
Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities
CIPSM in ARD & BR alpha television
Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association
Optische Kontrolle der Insulinsekretion mit einem Inkretinschalter
Long-Acting PASylated Leptin Ameliorates Obesity by Promoting Satiety and Preventing Hypometabolism in Leptin-Deficient Lepob/ob Mice
Molecular mechanisms behind the antimicrobial activity of hop iso-α-acids in Lactobacillus brevis
Anticalins directed against the fibronectin extra domain B as diagnostic tracers for glioblastomas
Sunlight-powered kHz rotation of a hemithioindigo-based molecular motor
Optimisation of a system for the co-translational incorporation of a keto amino acid and its application to a tumour-specific Anticalin
Evaluation of Kinase Activity Profiling Using Chemical Proteomics
Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogue
CRISPR-Cas: From the Bacterial Adaptive Immune System to a Versatile Tool for Genome Engineering
Engineering of alanine dehydrogenase from Bacillus subtilis for novel cofactor specificity
Alkynol natural products target ALDH2 in cancer cells by irreversible binding to the active site
Stability engineering of the Geobacillus stearothermophilus alcohol dehydrogenase and application for the synthesis of a polyamide 12 precursor
Kinetic and Theoretical Studies of Beta-Lactone Reactivity—A Quantitative Scale for Biological Application
Hemithioindigo—an emerging photoswitch
Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA)
Age-Dependent Levels of 5-Methyl-, 5-Hydroxymethyl-, and 5-Formylcytosine in Human and Mouse Brain Tissues
Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins
Dewar Lesion Formation in Single- and Double-Stranded DNA is Quenched by Neighboring Bases
|Phenyl Esters Are Potent Inhibitors of Caseinolytic Protease P and Reveal a Stereogenic Switch for Deoligomerization
Inhibitor-based affinity probes for the investigation of JAK signaling pathways
Histone Variant H2A.Z.2 Mediates Proliferation and Drug Sensitivity of Malignant Melanoma
89Zr-Labeled Versus 124I-Labeled αHER2 Fab with Optimized Plasma Half-Life for High-Contrast Tumor Imaging In Vivo
A Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets
Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition
Widespread Proteome Remodeling and Aggregation in Aging C. elegans
|Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links
|TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression
Crystal structure of the human odorant binding protein, OBPIIa
Orchestrating the Biosynthesis of an Unnatural Pyrrolysine Amino Acid for Its Direct Incorporation into Proteins Inside Living Cells
PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy
|A Mass Spectrometry Platform for a Streamlined Investigation of Proteasome Integrity, Posttranslational Modifications, and Inhibitor Binding
The Menagerie of Human Lipocalins: A Natural Protein Scaffold for Molecular Recognition of Physiological Compounds
|CIPSM-Mitgliedsversammlung 2015
|Promiscuous hydroxylases for the functionalization of polycyclic tetramate macrolactams – conversion of ikarugamycin to butremycin
AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
|Arginine-rhamnosylation as new strategy to activate translation elongation factor P
Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling
|Structure and Mechanism of the Caseinolytic Protease ClpP1/2 Heterocomplex from Listeria monocytogenes
Synthesis and biological evaluation of a novel MUC1 glycopeptide conjugate vaccine candidate comprising a 4'-deoxy-4'-fluoro-Thomsen–Friedenreich epitope
|Photocontrolled chignolin-derived β-hairpin peptidomimetics
Homology-driven assembly of NOn-redundant protEin sequence sets (NOmESS) for mass spectrometry
The dimeric crystal structure of the human fertility lipocalin glycodelin reveals a protein scaffold for the presentation of complex glycans
Design and Characterization of a Modular Membrane Protein Anchor to Functionalize the Moss Physcomitrella patens with Extracellular Catalytic and/or Binding Activities
|Season's Greetings and Best Wishes for a Happy New Year from CIPSM
|Cell-Penetrating and Neurotargeting Dendritic siRNA Nanostructures
|Effective GTP-Replacing FtsZ Inhibitors and Antibacterial Mechanism of Action
|Deciphering the role of the type II glyoxalase isoenzyme YcbL (GlxII-2) in Escherichia coli
DNA methylation and differential gene regulation in photoreceptor cell death
Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis
High contrast tumor imaging with radio-labeled antibody Fab fragments tailored for optimized pharmacokinetics via PASylation
|Structure of a Putative Fluorinated Natural Product from Streptomyces sp. TC1
Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns
|CIPSM-Business: CIPSM closes licence deal with BASF
|Making Fast Photoswitches Faster—Using Hammett Analysis to Understand the Limit of Donor–Acceptor Approaches for Faster Hemithioindigo Photoswitches
|Watson–Crick Base Pairing Controls Excited-State Decay in Natural DNA
|PAS-cal: A repetitive peptide sequence calibration standard for MALDI mass spectrometry
|Selective Inhibition of the Immunoproteasome by Ligand-Induced Crosslinking of the Active Site
|Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase
|Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition
|Enhanced in Vivo Efficacy of a Type I Interferon Superagonist with Extended Plasma Half-life in a Mouse Model of Multiple Sclerosis
|High susceptibility to fatty liver disease in two-pore channel 2-deficient mice
Ion mobility tandem mass spectrometry enhances performance of bottom-up proteomics
|Ribose-Protonated DNA Base Excision Repair: A Combined Theoretical and Experimental Study
|Making the Bend: DNA Tertiary Structure and Protein-DNA Interactions
|Exzellenzcluster trifft 8. Klasse am Gymnasium
|The Biocatalytic Repertoire of Natural Biaryl Formation
|Characterization of acute myeloid leukemia based on levels of global hydroxymethylation
Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach
|A multivariate approach to the integration of multi-omics datasets
|A Fab fragment directed against the neural cell adhesion molecule L1 enhances functional recovery after injury of the adult mouse spinal cord
|PAS-cal: a Generic Recombinant Peptide Calibration Standard for Mass Spectrometry
|Mass-spectrometry-based draft of the human proteome
|Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA
|Derivatization of Antibody Fab Fragments: A Designer Enzyme for Native Protein Modification
|Structural Basis for the Site-Specific Incorporation of Lysine Derivatives into Proteins
|Probing SH2-domains using Inhibitor Affinity Purification (IAP)
|New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics
Antibody Recognition of Fluorinated Haptens and Antigens
|Charge separation and charge delocalization identified in long-living states of photoexcited DNA
|A Subfamily of Bacterial Ribokinases Utilizes a Hemithioacetal for Pyridoxal Phosphate Salvage
|Fingerprinting DNA Oxidation Processes: IR Characterization of the 5-Methyl-2′-Deoxycytidine Radical Cation
|A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice
|CIPSM Awards 2014
|Targeted Mutagenesis Results in an Activation of DNA Methyltransferase 1 and Confirms an Autoinhibitory Role of its RFTS Domain
|Biochemical Analysis of Recombinant AlkJ from Pseudomonas putida Reveals a Membrane-Associated, Flavin Adenine Dinucleotide- Dependent Dehydrogenase Suitable for the Biosynthetic Production of Aliphatic Aldehydes
|Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy
|Formation and Direct Repair of UV-induced Dimeric DNA Pyrimidine Lesions
|Synthesis of functionalized α-trifluoroethyl amine scaffolds via Grignard addition to N-aryl hemiaminal ethers
|Anticalins: Exploiting a non-Ig scaffold with hypervariable loops for the engineering of binding proteins
|A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors
|Omuralide and Vibralactone: Differences in the Proteasome- β-Lactone-γ-Lactam Binding Scaffold Alter Target Preferences
|Synthese eines DNA-Promotorsegments mit allen vier epigenetischen Nukleosiden: 5-Methyl-, 5-Hydroxymethyl-, 5-Formyl- und 5-Carboxy-2′-Desoxycytidin
|Frohe Weinhachten und ein gutes neues Jahr!
|Sortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting of the plant cytotoxin gelonin
|A Photoswitchable Neurotransmitter Analogue Bound to Its Receptor
|α-Methylene-γ-butyrolactones attenuate Staphylococcus aureus virulence by inhibition of transcriptional regulation
|Structural Insights into Incorporation of Norbornene Amino Acids for Click Modification of Proteins
|β-Sultams exhibit discrete binding preferences for diverse bacterial enzymes with nucleophilic residues
|Copper-Assisted Click Reactions for Activity-Based Proteomics: Fine-Tuned Ligands and Refined Conditions Extend the Scope of Application
|Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition
|Comprehensive Identification of Proteins from MALDI Imaging
|Norbornenes in Inverse Electron-Demand Diels–Alder Reactions
|CIPSM on the run
|CIPSM Scientific Oktoberfest 2013
Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF-Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity
|Deamination, Oxidation, and C−C Bond Cleavage Reactivity of 5‑Hydroxymethylcytosine, 5‑Formylcytosine, and 5‑Carboxycytosine
|DMSO enhances electrospray response, boosting sensitivity of proteomic experiments
|A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization
|Global Proteome Analysis of the NCI-60 Cell Line Panel
|Characterization of a high field Orbitrap mass spectrometer for proteome analysis
|Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad
|Crystallographic Analysis and Structure-Guided Engineering of NADPH-Dependent Ralstonia sp. Alcohol Dehydrogenase Toward NADH Cosubstrate Specificity
|The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
|The Two Faces of Potent Antitumor Duocarmycin-Based Drugs: A Structural Dissection Reveals Disparate Motifs for DNA versus Aldehyde Dehydrogenase 1 Affinity
|Nature calls CIPSM a prime example for a working conduit between university, non-university and R&D business in Germany. "CIPSM features regularly in the Nature Publicing Index"
|Characterization of a Chemical Affinity Probe Targeting Akt Kinases
|Measuring and Managing Ratio Compression for Accurate iTRAQ/ TMT Quantification
|PASylation: a biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins
|Total Synthesis of the Hypermodified tRNA Nucleoside Epoxyqueuosine
|Unexpected non-Hoogsteen–based mutagenicity mechanism of FaPy-DNA lesions
A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics
|MScDB: A Mass Spectrometry-centric Protein Sequence Database for Proteomics
|Cleavable trifunctional biotin reagents for protein labelling, capture and release
|Structural basis for the enzymatic formation of the key strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone
|Proteomic workflow for analysis of archival formalin-fixed and paraffin-embedded clinical samples to a depth of 10 000 proteins
|Comparing Immobilized Kinase Inhibitors and Covalent ATP Probes for Proteomic Profiling of Kinase Expression and Drug Selectivity
|The Mechanism of Caseinolytic Protease (ClpP) Inhibition
|Combinatorial Design of an Anticalin Directed against the Extra-Domain B for the Specific Targeting of Oncofetal Fibronectin
|Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
|Total Synthesis of the Hypermodified RNA Bases Wybutosine and Hydroxywybutosine and Their Quantification Together with Other Modified RNA Bases in Plant Materials
|Tuning probe selectivity for chemical proteomics applications
|Conformational Selection in Substrate Recognition by Hsp70 Chaperones
|Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay
|Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III amino- transferases that have biotechnological potential
|Proteome Wide Purification and Identification of O-GlcNAc-Modified Proteins Using Click Chemistry and Mass Spectrometry
|Synthesis of 5-Hydroxymethyl-, 5-Formyl-, and 5-Carboxycytidine-triphosphates and Their Incorporation into Oligonucleotides by Polymerase Chain Reaction
|Total Syntheses and Biological Evaluation of 3-O-Methylfunicone and Its Derivatives Prepared by TMPZnCl·LiCl-Mediated Halogenation and Carbonylative Stille Cross-Coupling
|Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
|SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
|Target profiling of 4-hydroxyderricin in S. aureus reveals seryl-tRNA synthetase binding and inhibition by covalent modification
|Alternative bacterial two-component small heat shock protein systems
|The radical SAM enzyme spore photoproduct lyase employs a tyrosyl radical for DNA repair
|Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 30-splice site recognition
|Synthesis of ε-N-propionyl-, ε-N-butyryl-, and ε-N-crotonyl-lysine containing histone H3 using the pyrrolysine system
|Quantification of the N-glycosylated Secretome by Super-SILAC During Breast Cancer Progression and in Human Blood Samples*
Isotope-Based Analysis of Modified tRNA Nucleosides Correlates Modification Density with Translational Efficiency
|A Simple and Effective Cleavable Linker for Chemical Proteomics Applications Yinliang Yang,
|Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein–Ligand Binding
|Deactivation of the E. coli pH Stress Sensor CadC by Cadaverine
|Azo-Propofols: Photochromic Potentiators of GABAA Receptors
|Global analysis of genome, transcriptome and proteome reveals the response to aneuploidy in human cells
|Evolution of a Synthetic Strategy for the Variecolortide
A Conformationally Frozen Peptoid Boosts CXCR4 Affinity and Anti-HIV Activity
|Nature mentions CIPSMs' graduate educational program in it's highlight article about the German Excellence Initiative
|Exploring the Pharmacology and Action Spectra of Photochromic Open-Channel Blockers
|Homotypic Interaction and Amino Acid Distribution of Unilaterally Conserved Transmembrane Helices
In vitro Percutaneous Absorption of 14C-Labeled β-Lactone Promises Topical Delivery of New Bacterial Virulence Inhibitors
|Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme
Structure and Function of Noncanonical Nucleobases
|CIPSM selected as Cluster of Excellence once more... YEAH!
Dynamics of ultraviolet-induced DNA lesions: Dewar formation guided by pre-tension induced by the backbone
|Sequence-dependent backbone dynamics of a viral fusogen transmembrane helix
|Discovery of the HSP90 regulated proteome by CIPSM scientists featured on the cover of Mol Cell Proteomics
|Synthetic approaches toward sesterterpenoids
|A Unified Approach to trans-Hydrindane Sesterterpenoids
|Stereoselective Total Syntheses of Herbicidin C and Aureonuclemycin through Late-Stage Glycosylation
|Mechanism and Stem-Cell Activity of 5-Carboxycytosine Decarboxylation Determined by Isotope Tracing
|ONIOM approach for non-adiabatic on-the-fly molecular dynamics demonstrated for the backbone controlled Dewar valence isomerization
|Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy
|A Total Synthesis Prompts the Structure Revision of Haouamine B
|A Genetically Encoded Norbornene Amino Acid for the Mild and Selective Modification of Proteins in a Copper-Free Click Reaction
|A Photochromic Agonist of AMPA Receptors
|Electrophilic natural products and their biological targets
|Mechanism of Translesion Transcription by RNA Polymerase II and Its Role in Cellular Resistance to DNA Damage
|H2A.Z.2.2 is an alternatively spliced histone H2A.Z variant that causes severe nucleosome destabilization
|The CDK5 repressor CDK5RAP1 is a methylthiotransferase acting on nuclear and mitochondrial RNA
|Total Synthesis of Exiguamines A and B Inspired by Catecholamine Chemistry
|The 19S Cap Puzzle: A New Jigsaw Piece
Radiolabelled RGD peptides for imaging and therapy
|Rapid optical control of nociception with an ion-channel photoswitch
|Rapid optical control of nociception with an ion-channel photoswitch
|Immuno- and Constitutive Proteasome Crystal Structures Reveal Differences in Substrate and Inhibitor Specificity
|Discovery and Mutagenicity of a Guanidinoformimine Lesion as a new Intermediate of the Oxidative Deoxyguanosine Degradation Pathway
|Consecutive Proteolytic Digestion in an Enzyme Reactor Increases Depth of Proteomic and Phosphoproteomic Analysis
|Crystal Structure of Methylornithine Synthase (PylB): Insights into the Pyrrolysine Biosynthesis
|Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis
|Exploiting nature's rich source of proteasome inhibitors as starting points in drug development
|An Approach to Aminonaphthoquinone Ansamycins Using a Modified Danishefsky Diene
|Insights into the Structural Network Responsible for Oligomerization and Activity of the Bacterial Virulence Regulator Caseinolytic Protease P (Clpp)
|Development and characterization of improved β-lactone-based anti-virulence drugs targeting Clp
Low values of 5-hydroxymethylcytosine (5hmC), the ''sixth base,'' are associated with anaplasia in human brain tumors
|Optochemical control of genetically engineered neuronal nicotinic acetylcholine receptors
|Mechanism of UV-Induced Formation of Dewar Lesions in DNA
|The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop
Beta-Lactams and Beta-lactones as activity-based probes in chemical biology
|Tetraalkylcuprates(III): Formation, Association, and Intrinsic Reactivity
|Optochemical Genetics
|Improved Synthesis and Mutagenicity of Oligonucleotides Containing 5-Hydroxymethylcytosine, 5-Formylcytosine and 5-Carboxylcytosine
|Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes
|Deep proteome and transcriptome mapping of a human cancer cell line
|The RIG-I ATPase domain structure reveals insights into ATP-dependent antiviral signalling
|Systems-Based Analysis of Modified tRNA Bases
|Pictures of the Scientific Oktoberfest 2011
|Scientific Oktoberfest: CIPSM-Fest of Chemical Biology 2011
|Design, Synthesis, and Functionalization of Dimeric Peptides Targeting Chemokine Receptor CXCR4
|Reversible bond formation enables the replication and amplification of a crosslinking salen complex as an orthogonal base pair
|The Discovery of 5-Formylcytosine in Embryonic Stem Cell DNA
|PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
|5-Hydroxymethylcytosine, the Sixth Base of the Genome
|Unraveling the Protein Targets of Vancomycin in Living S. aureus and E. faecalis Cells
|Evaluation of α-Pyrones and Pyrimidones as Photoaffinity Probes for Affinity-Based Protein Profiling
|Recognition of 5-Hydroxymethylcytosine by the Uhrf1 SRA Domain
|An efficient synthesis of loline alkaloids
|Tuning Photochromic Ion Channel Blockers
|Identification and characterization of a novel ubiquitous nucleolar protein 'NARR' encoded by a gene overlapping the rab34 oncogene
|A Conformational Switch Underlies ClpP Protease Function
|High Recovery FASP Applied to the Proteomic Analysis of Microdissected Formalin Fixed Paraffin Embedded Cancer Tissues Retrieves Known Colon Cancer Markers
|A Novel Two-Stage Tandem Mass Spectrometry Approach and Scoring Scheme for the Identification of O-GlcNAc Modified Peptides
|Discovery and Synthesis of New UV-Induced Intrastrand C(4−8)G and G(8−4)C Photolesions
|Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases
|Structure and dynamics of the lipid modifications of a transmembrane Alpha-helical peptide determined by 2H solid-state NMR spectroscopy
|Biosynthesis of a Fluorescent Protein with Extreme Pseudo-Stokes Shift by Introducing a Genetically Encoded Non-Natural Amino Acid outside the Fluorophore
|Synthetic Studies toward A-74528
|Concise Total Syntheses of Variecolortides A and B through an Unusual Hetero-Diels–Alder Reaction
|Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family
|Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
|New Insights into the Signaling Mechanism of the pH-responsive, Membrane-integrated Transcriptional Activator CadC of Escherichia coli
The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity
Protein Reactivity of Natural Product-Derived γ-Butyrolactones
|Tissue Distribution of 5-Hydroxymethylcytosine and Search for Active Demethylation Intermediates
Biosynthesis of Isoprenoids: Crystal Structure of the [4Fe–4S] Cluster Protein IspG
|Elucidation of the a-Keto-Aldehyde Binding Mechanism: A Lead Structure Motif for Proteasome Inhibition
|Comparison of ultrafiltration units for proteomic and N-glycoproteomic analysis by the filter-aided sample preparation method
|Toward the Total Synthesis of Maoecrystal V: Establishment of Contiguous Quaternary Stereocenters
Mechanism of replication blocking and bypass of Y-family polymerase Eta by bulky acetylaminofluorene DNA adducts
Ferredoxin:NADPH oxidoreductase is recruited to thylakoids by binding to a polyproline type II helix in a pH-dependent manner
Confident phosphorylation site localization using the Mascot Delta Score
Residue-Specific Side-Chain Packing Determines the Backbone Dynamics of Transmembrane Model Helices
|The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds
Reductive Dehydroxylation of Allyl Alcohols by IspH Protein
|Pharmacology of ionotropic glutamate receptors: A structural perspective
|CIPSM spin-off AVIRU gets funding from the German Parliament
|Synthesis and Antiplasmodial Activity of Highly Active Reverse Analogues of the Antimalarial Drug Candidate Fosmidomycin
|20S Proteasome Inhibition: Designing Noncovalent Linear Peptide Mimics of the Natural Product TMC-95A
|Total synthesis of newbouldine via reductive N - N bond formation
Biomimetic Synthesis of (−)-Pycnanthuquinone C through the Diels–Alder Reaction of a Vinyl Quinone
|Quantification of the Sixth DNA Base Hydroxymethylcytosine in the Brain
Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
Proteomics: a pragmatic perspective
|CIPSM spin-off XL-protein GmbH awarded with the 2010 Science4Life Venture Cup
|Chemical Probes for Labeling of the Bacterial Glucosaminidase NagZ via the Huisgen Cycloaddition
The 26S proteasome: assembly and function of a destructive machine
|CIPSM at the elementary school
|Proteome, Phosphoproteome, and N-Glycoproteome Are Quantitatively Preserved in Formalin-Fixed Paraffin-Embedded Tissue and Analyzable by High-Resolution Mass Spectrometry
|Exzellenzinitiative für die Grundschule - CIPSM unterrichtet Grundschüler
|Thomas Carell was honored with the Cross of Merit on ribbon of the Federal Republic of Germany
Showdomycin as a Versatile Chemical Tool for the Detection of Pathogenesis-Associated Enzymes in Bacteria
|Brain Phosphoproteome Obtained by a FASP-Based Method Reveals Plasma Membrane Protein Topology
|Oxidation State, Aggregation, and Heterolytic Dissociation of Allyl Indium Reagents
Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies
|Crystal Structure of a Cisplatin-(1,3-GTG) Cross-Link within DNA Polymerase eta
|A Highly Charged Ag6 4+ Core in a DNA-Encapsulated Silver Nanocluster
DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization into (6-4) Lesions
|Probing the reaction mechanism of IspH protein by x-ray structure analysis
|Structural features of fusogenic model transmembrane domains that differentially regulate inner and outer leaflet mixing in membrane fusion
|Ionic interactions promote transmembrane helix-helix association depending on sequence context
|Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice
|Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids
|Light Commands Ion Channel
|Microsolvated and Chelated Butylzinc Cations: Formation, Relative Stability, and Unimolecular Gas-Phase Chemistry
Combination of FASP and StageTip-Based Fractionation Allows In-Depth Analysis of the Hippocampal Membrane Proteome
|CIPSM PI and board member Arne Skerra and his new spin-off company XL-protein GmbH prolong the plasma half-life of biopharmaceutical substances
|DynaDock: A new molecular dynamics-based algorithm for protein-peptide docking including receptor flexibility
|A Photolabile Linker for the Mild and Selective Cleavage of Enriched Biomolecules from Solid Support
|A new crystal form of human tear lipocalin reveals high flexibility in the loop region and induced fit in the ligand cavity
Parallel Isotope-Based Quantification of Modified tRNA Nucleosides
|Syringolin A Selectively Labels the 20S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines
|Once Overlooked, Now Made Visible: ATL Proteins and DNA Repair
|Crystal Structure of the T(6-4)C Lesion in Complex with a (6-4) DNA Photolyase and Repair of UV-Induced (6-4) and Dewar Photolesions
|Snapshots of the Fluorosalinosporamide/20S Complex Offer Mechanistic Insights for Fine Tuning Proteasome Inhibition
|beta-Lactones Decrease the Intracellular Virulence of Listeria monocytogenes in
|Prolonged stability by cyclization: Macrocyclic phosphino dipeptide isostere inhibitors of ß-secretase (BACE1)
|A new ground state single electron donor for excess electron transfer studies in DNA
|Structure of Active IspH Enzyme from Escherichia coli Provides Mechanistic Insights into Substrate Reduction
NMR Structure and Dynamics of the Engineered Fluorescein-Binding Lipocalin FluA Reveal Rigidification of β-Barrel and Variable Loops upon Enthalpy-Driven Ligand Binding
|Alpenforum 2009
|Structural biology of DNA photolyases and cryptochromes
|CIPSM-Harvard Young Scientists' Forum (YSF)
|Cinnamic aldehyde derived probes for the active site labelling of pathogenesis associated enzymes
|Interaction and conformational dynamics of membrane-spanning protein helices
|Stabilization of conformationally dynamic helices by covalently attached acyl chains
|Bilder von der CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
|An engineered lipocalin specific for CTLA-4 reveals a combining site with structural and conformational features similar to antibodies
|CIPSM-Festveranstaltung im Deutschen Museum am 4. Mai 2009
The archaeal cofactor F0 is a light-harvesting antenna chromophore in eukaryotes
|Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein
|Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains
|Synthetic and structural studies on syringolin A and B reveal critical determinants of selectivity and potency of proteasome inhibition
|Universal sample preparation method for proteome analysis
|Sequence-specific conformational dynamics of model transmembrane domains determines their membrane fusogenic function
|beta-Lactam Probes As Selective Chemical-Proteomic Tools for the Identification and Functional Characterization of Resistance Associated Enzymes in MRSA
Copper-Free "Click" Modification of DNA via Nitrile Oxide-Norbornene 1,3-Dipolar Cycloaddition
|Protein Iodination by Click Chemistry
|CIPSM Movie online stream
|Allosteric Switches: Remote Controls for Proteins
|Unraveling the Secrets of Protein-Metabolite Interactions
Imaging of integrin alpha-v-beta-3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography
|High-Affinity Recognition of Lanthanide(III) Chelate Complexes by a Reprogrammed Human Lipocalin 2
Phosphorothioation of Oligonucleotides Strongly Influences the Inhibition of Bacterial (M.HhaI) and Human(Dnmt1) DNA Methyltransferases
|Structurally Refined b-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
|Crystal structure analysis of DNA lesion repair and tolerance mechanisms
|A Pan-Specific Inhibitor of the Polo-Box Domains of Polo-like Kinases Arrests Cancer Cells in Mitosis
Importin 8 Is a Gene Silencing Factor that Targets Argonaute Proteins to Distinct mRNAs
|Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals
|Formation of Organozincate Anions in LiCl-Mediated Zinc Insertion Reactions
|Controlled Nucleation of DNA Metallization
The persisting challenge of selective and specific proteasome inhibition
|Aggregation and Reactivity of Organozincate Anions Probed by Electrospray Mass Spectrometry
|Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome
|Identification of potential substrate proteins for the periplasmic Escherichia coli chaperone Skp
|CIPSM ist Ausgewählter Ort im Land der Ideen
|A Human snoRNA with MicroRNA-Like Functions
|Novel Diazirine-Containing DNA Photoaffinity Probes for the Investigation of DNA-Protein-Interactions
|Evidence for Insertional RNA Editing in Humans
|5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Complex patterns of histidine, hydroxylated amino acids and the GxxxG motif mediate high-affinity transmembrane domain interactions
|Crystal Structure and Mechanism of a DNA (6-4) Photolyase
|Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment
|Leaving Groups Prolong the Duration of 20S Proteasome Inhibition and Enhance the Potency of Salinosporamides
|Azatryptophans endow proteins with intrinsic blue fluorescence
|Structural Analysis of Spiro b-Lactone Proteasome Inhibitors
|CIPSM-Researchers Stephan Sieber and Thomas Böttcher win the Innovation award 2008 of the BioRegions in Germany
|Beta-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors of Staphylococcus aureus
|Postsynthetic DNA Modification through the Copper-Catalyzed Azide–Alkyne Cycloaddition Reaction
|The 1.8-Å Crystal Structure of α1-Acid Glycoprotein (Orosomucoid) Solved by UV RIP Reveals the Broad Drug-Binding Activity of This Human Plasma Lipocalin
|Beta-Lactams as Selective Chemical Probes for the in Vivo Labeling of Bacterial Enzymes Involved in Cell Wall Biosynthesis, Antibiotic Resistance, and Virulence
|Hier geht was!
|Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells
|Convenient syntheses of homopropargylglycine
|Inhibition of transcription factors with small organic molecules
|Inhibition of transcription factors with small organic molecules
|Exploiting Cross-Amyloid Interactions To Inhibit Insulin Aggregation but not Function: Nanomolar Affinity Inhibition of Insulin Aggregation by an IAPP Mimic
|Biomimetic synthesis of the IDO inhibitors exiguamine A and B
|Sequence-Specific Conformational Flexibility of SNARE Transmembrane Helices Probed by Hydrogen/Deuterium Exchange
|Synthesis and properties of DNA containing a spore photoproduct analog
|Fpg (MutM) recognizes bulky N7-substituted-FapydG lesion using a novel and unproductive binding mode
|Synthesis of a Stabilized Version of the Imidazolone DNA Lesion
|Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction
|Docking of tryptophan analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations
|A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase
|Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions
|Signal Transducers and Activators of Transcription as Targets for Small Organic Molecules
|Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram
|A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
|beta-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes
|Efficient N-Terminal Glycoconjugation of Proteins by the N-End Rule
|Synthetic Biology of Proteins: Tuning GFPs Folding and Stability with Fluoroproline
|Bayer Schering Pharma and CIPSM sign a strategic partnership
|Discovery of Chromone-Based Inhibitors of the Transcription Factor STAT5
|Synthesis of DNA Dumbbell Based Inhibitors for the Human DNA Methyltransferase Dnmt1
|A high-throughput assay for signal transducer and activator of transcription 5b based on fluorescence polarization
|Requirement for Small Side Chain Residues within the GxGD-Motif of Presenilin for gamma-Secretase Substrate Cleavage
|Dissecting the Differences between the a and b Anomers of the Oxidative DNA Lesion FaPydG
|The carbohydrate recognition domain of Langerin reveals high structural similarity with the one of DC-SIGN but an additional, calcium-independent sugar-binding site
|Selective Detection of 5-Methylcytosine Sites in DNA
Secondary structure and distribution of fusogenic LV-peptides in lipid membranes
|CIPSM-Speaker Thomas Carell wins 2008 Otto-Bayer-Preis
|Nature Spotlight on Germany
|Seeing Cisplatin - Discerning how an anticancer drug meddles with replication, transcription
|Mechanism of transcriptional stalling at cisplatindamaged DNA
|Bypass of DNA Lesions Generated During Anticancer Treatment with Cisplatin by DNA Polymerase Eta
|Structural Insight into the Dual Ligand Specificity and Mode of High Density Lipoprotein Association of Apolipoprotein D
|miRNAs Get an Early Start on Translational Silencing
|Phenylalanine Promotes Interaction of Transmembrane Domains via GxxxG Motifs
|The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins
CPD Damage Recognition by Transcribing RNA Polymerase II


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SAN JOSE, Calif., Nov. 2 /PRNewswire-FirstCall/ -- Atmel(R) Corporation (NASDAQ: ATML) today announced the availability of the Xplain evaluation kit for its AVR(R) XMEGA(TM) microcontroller family. With a suggested resale price of $29 USD, this kit enables users the ability to evaluate features and system performance of Atmel's XMEGA at a minimum hardware cost. The kit is powered through a mini USB connector where end-users can develop their own applications on XMEGA using Xplain. The 8-/16-bit XMEGA microcontrollers, introduced in 2008, are optimized for ultra- low power and high system performance with a very innovative and complete feature set well suited for a wide range of applications.
Atmel's ATxmega128A1 is the onboard XMEGA device in the Xplain kit. The device is a 100-pin, general purpose microcontroller with 128 KB of In-System Programmable Flash memory and an 8 KB boot section in Flash that can also be used as additional application memory. The ATxmega128A1 contains all features available in the XMEGA family which includes, but is not limited to, a DMA controller, Event System, 12-bit high speed analog peripherals, AES and DES crypto module, external bus interface and all second-generation picoPower(TM) features achieving the market's lowest power consumption microcontrollers.
For evaluation and development purposes, the Xplain kit contains a speaker with an audio amplifier, a potentiometer and temperature sensor, which are all connected to the 12-bit DAC or ADC on the ATxmega128A1 device. The external memories include an 8 MB SDRAM and an 8 MB serial data Flash, and eight buttons and eight LEDs for basic user interface and application interaction are also available. Spare digital and analog pins on the ATxmega128A1 are available through pin-headers for external analog input and output, digital input and output, PWM, input capture, and USART, SPI and I2C-compatible TWI communication.
The Xplain kit is shipped with basic code programmed into the ATxmega128A1 to demonstrate the use of buttons, LEDs and the speaker on the kit. Documentation includes a user guide, schematics and a full bill of materials available at: http://www.atmel.com/Xplain. Additional code examples, good design practices recommendations and general hints and tips are available as application notes at: http://www.atmel.com/AVR.
Xplain supports other development tools from Atmel including the JTAGICE mkII debugger, AVRISP mkII programmer and AVR Studio(R) - the free AVR IDE Software Development Tool available at http://www.atmel.com/AVRStudio. By using these tools with Xplain, users have the ability to do on-chip debugging or in-system programming.
More information on the XMEGA microcontroller family is available at: http://www.atmel.com/XMEGA.
Availability, Pricing and Photo
The Xplain kit is available now. Suggested retail price is $29 USD per kit.
To download a high-resolution of the Xplain board, please click the following link: http://www.atmel.com/images/homepage_new/press/xplain_side.jpg.
About Atmel
Atmel is a worldwide leader in the design and manufacture of microcontrollers, advanced logic, mixed-signal, nonvolatile memory and radio frequency (RF) components. Leveraging one of the industry's broadest intellectual property (IP) technology portfolios, Atmel is able to provide the electronics industry with complete system solutions focused on consumer, industrial, security, communications, computing and automotive markets.
(C) 2009 Atmel Corporation. All Rights Reserved. Atmel(R), Atmel logo and combinations thereof, AVR, AVR Studio(R), picoPower(R) and others are registered trademarks, XMEGA(TM) and others are trademarks of Atmel Corporation or its subsidiaries. Other terms and product names may be trademarks of others.
Atmel's Xplain product information is available at, http://www.atmel.com/Xplain.
For further information on the AVR XMEGA product family, visit http://www.atmel.com/XMEGA.
Atmel Press Contacts: Clive Over, Director of Public Relations +1 (408) 436 4305, Email: firstname.lastname@example.com
Web site: http://www.atmel.com/


text: So, any good ways to test a torque wrench? I don't trust mine, but it's pretty new so I feel I should. I'm planning on changing spark plugs and don't want to risk over tightening. The background: I'm on my 3rd Craftsman torque wrench. The first two wouldn't 'click' from time to time...that is a bad thing. Sears won't accept a return, but gave me credit I could use for another model. I bought their "Microtork" model for around $70. However, when torquing the oil drain plug, and the wrench set at 18 N-m, it sure seemed like I was past that before it clicked. Or was it just the awkward angle I was at? Thanks