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Our Problems Part 4 Why Things are So Bad
People dwell on the world's many problems. And there are an endless number of them – religious fanaticism, war, racism, crime, poverty, environmental degradation and so forth. Reactionaries treat this misery as "man's fate". Some even revel in it, awaiting the destruction of the world when Jesus will beam them up. Progressives on the other hand, look for the source in structural terms such as capitalism, class systems, authoritarianism or patriarchy. But progressives are bewildered by the irrational behavior of so many people, a behaviour that aids and abets those structural causes of human suffering. In a nut shell, structural explanations, while fundamental truths, are not a complete explanation of why things are the way they are.
Abused individuals act in self-destructive ways. These include passivity, lack of curiosity, impulsiveness, obsessiveness, substance abuse, child and spousal abuse. I contend that the human race itself is a collective patient recovering from severe physical, emotional, verbal and sexual abuse and this abuse is the root cause of the irrational behaviour that so bewilders progressives. I say a recovering patient because most of the abuse took place in the past, most particularly in the late 19th to mid-20th Centuries. (This is, of course, not to ignore the recent horrors in Latin America with fascist coups and death squads, nor contemporary religious "fundamentalism".)
Abuse has an effect well beyond the generation that experienced it directly. Abusive behaviour is passed down from one generation to another, but even where this is not the case, there is still a negative effect upon succeeding generations. Someone raised by abusive parents who manages to break the cycle of abuse, might become overly protective of their children, thereby creating another set of, albeit lesser, problems. Someone raised in a sexually repressive attitude, may in rejecting this oppression, go to the other extreme and become irresponsible in their sexual relations.
As with the individual, so too with the multitude. Three or four generations ago abusive behaviour was the normal method of childrearing. (in the Anglosphere and Germany, most especially). One instilled fear in one's children. Emphasis was placed upon subservience to authority. Praise was avoided and children were constantly reminded of their inferior status. Methods involved heavy doses of guilt, humiliation, and other forms of emotional abuse. If this wasn't enough to make the child subservient, verbal and physical abuse were freely used. All these crimes against children were committed in the name of "love" for the child, creating a schizophrenic situation where love = pain and degradation.
The ultimate source of most of these horrors, and with their own particular variety of cruelty, stood the religious cults. The cults terrorized the young into submissiveness with visions of Hell-fire, should they show any independence or rebelliousness. They were taught to feel guilty about merely existing. Children were also taught to hate and fear the body and its reactions, especially those of a sexual nature. Natural desires were repressed to the full. Both religious and secular authorities worked full time to maximize sexual repression, not just among the young, but among adults as well. To add an even more grotesque twist, these same authorities sexually molested their charges or frequented houses of prostitution.
My tour through this genuine Hell, would not be complete without mentioning the extreme racism and misogyny that shouted from every corner. Anyone who was not Anglo-Saxon was branded as second class and this was enforced through the media and popular culture. This is abuse, and yet the Polish or Italian immigrant was to get off easy in comparison to groups even less-favoured. For people of color, endless degradation and humiliation. For First Nations, genocide. For African-Americans, a reign of terror.
Sixty years ago, and for generations before that, women were considered silly, mindless creatures, capable only of bearing and nurturing children. Any natural desire to do anything else was to be suppressed. A woman was second class compared to a man, and was duty bound to obey Father and then Husband. Sexuality was even more harshly repressed in women than in men. Thus, women had to endure severe emotional abuse and if this did not work to keep them emotionally enslaved, verbal and physical abuse were considered legitimate means.
No, I am not engaging in psychological reductionism. The structural causes of our suffering, class systems, authoritarian hierarchies and capitalism, are real, but they do not explain why many are willing to put up with exploitation and bullying, the natural results of these same structural causes. Nor do they explain the large minority who envy, emulate, or worship their Masters and cheerfully persecute, torture or kill those who seek their liberation. Given our history, we are where we ought to be. Those of us who have tried to live in more liberatory and humane ways still carry the legacy of generations of psychologically wounded people. Millions still live in that past, lying trapped in authoritarianism, racism, sexism and a multitude of other manifestations of abuse. It will take several generations more to overcome our cruel burden. But time is running out. The problems pile up too fast to wait for the population to recover. We, imperfect creatures that we are, must work to make the world a saner place, at the same time realizing we will make errors, and there will be difficulties strewn in our path by our past histories.

subset: commoncrawl


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NASHVILLE, Tenn. -- Mike Mularkey is returning as Tennessee Titans head coach and is talking with the team about a contract extension that would keep him in town beyond the 2018 season, a league source confirmed to ESPN.
Initial talks began last week following the Titans' 22-21 wild-card playoff victory over the Kansas City Chiefs.
The Titans made progress in 2017, finishing 9-7 and making the playoffs for the first time since the 2008 season. They overcame an 18-point deficit at Kansas City to win their first playoff game since the 2003 season. Their season ended with a 35-14 divisional-round playoff loss at New England. Mularkey has gone 19-15 (including playoffs) in his two seasons as full-time head coach. His contract is currently set to expire following the 2018 season.
It seems the Titans' playoff run and growing culture has contributed to the team's decision to stick with Mularkey despite some offensive struggles. The Titans finished 23rd in the NFL in total offense and passing offense.
"Yeah, we're moving forward full speed ahead," Mularkey said Sunday afternoon in his end-of-season news conference, while declining to address the status of his extension talks. "Going to give the coaches off this week and get us into the Senior Bowl next week. Got a lot of work to do with two weeks into the offseason already."
There was a lot of speculation and reports regarding Mularkey's uncertain job security prior to Week 17's win over the Jacksonville Jaguars to make the playoffs and the Kansas City matchup a week later. Mularkey called the situation "ridiculous" and noted the lack of support he felt from the Titans organization. Titans controlling owner Amy Adams Strunk gave him a vote of confidence that has led to his 2018 return and likely longer.
NFL Network was the first to report Mularkey's extension talks with the Titans.
Moving forward, the Titans are happy with their progress but hoping they can reach the next level of being a championship contender in coming seasons.
Mularkey said he does not anticipate making changes to his staff while lauding the job that offensive coordinator Terry Robiskie has done as the team's playcaller. Mularkey also said he has not talked with defensive coordinator Dick LeBeau, or his other assistants, but he was happy with LeBeau's job as defensive coordinator and anticipates he will return.
"He's an amazing man," Mularkey said.
LeBeau, 80, has 59 consecutive seasons as a NFL player or coach. He makes his decision on whether to return on a yearly basis after the season is over.
Mularkey's desire for continuity on his staff coincides with his happiness in quarterback Marcus Mariota's development. Mariota had his worst season statistically as a NFL QB in 2017, throwing for a career-low 13 passing touchdowns and career-high 15 interceptions during the regular season, but Mularkey linked those numbers to the various injuries Mariota suffered during the season, and some mistakes by his young receivers.
A Mularkey extension would make any potential open assistant position on his coaching staff more attractive for outside candidates.
The next challenge for Mularkey and his staff is to figure out how to maximize Mariota's skill set and elevate the offense to match up better against the AFC's elite teams. This will be more important next season as the AFC South strengthens with Jacksonville's emergence along with the likely returns of quarterbacks Deshaun Watson and Andrew Luck to the Houston Texans and Indianapolis Colts, respectively.


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Recently, I wrote an article listing some unpleasant, stubborn EMR problems that are likely to cling to the industry like sticky burrs in 2013. Being a fair-minded gal, I also wanted to stop and reflect on what's likely to work in favor of EMR adoption, maturation and success next year, so here goes:
* Consolidation will lead to a more-stable vendor market: With the (in my opinion) wave of new EMR vendors beginning to recede, the shakeout will begin. Vendors that remain may not be the best, sadly, but they'll be better funded and hopefully better situated to take care of customers.
* We'll have a good amount of Meaningful Use experience under our belts: Starting out with Meaningful Use has been nerve-wracking for all. But by 2013 the industry will have begun to acclimate itself not just to meeting MU standards, but making them work for their particular clinic or hospital.
* Vendors are likely to offer more mobile options: Right now, EMR vendors are offering minimal efforts around mobile EMR applications. My gut is that in the coming year, we'll see some definitive progress on Android and iOS-natve EMR apps. There's just too much demand to ignore.
* Template medicine will get more sophisticated: When templates merely inconvenienced doctors, nobody seemed that worried about their potential side effects. Now that it appears that templates encourage costly upcoding, however, it's likely that vendors will be forced to make them smarter and less prone to encouraging cut-and-paste documentation. (How, I haven't a clue, but the pressure will force something to happen.)
Now, none of these are exactly raving endorsements of the EMR climate for next year. I'm not suggesting that adopting EMRs will suddenly become easy, training a breeze or ROI will magically appear. But I do believe that we're going to be seeing a nice uptick in EMR maturity.


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Crocodile attack victim Trent Burton remains at Shoalhaven Hospital near Wollongong being treated for hand injuries after being bitten on the hand and dragged into the water during a school holiday show at Shoalhaven Zoo at North Nowra.
Mr Burton, an animal handler, was reported to be waiting for x-rays to be taken on his damaged hands and then have stitches to puncture wounds.
It is understood Mr Burton still had feelings in his fingers, which was an early indication he may have escaped any possible nerve damage.
Ambulance rescue paramedics Darren Hamdorf and Irwin Burbage admitted it was "rather unusual to be called to a job for a croc attack".
"It's certainly not the sort of call out you get every day," Paramedic Hamdorf said.
"When the call came in, one of our colleagues commented that they hoped the patient still wasn't in the cage.
"It may have been a bit difficult to extract him from in there."
Paramedic Hamdorf said the patient was "pretty calm".
"He had a couple of holes in his hands, but seemed fine. He seemed more upset with himself that it had actually happened," he said.
"He walked himself to the ambulance.
"He told us his first hand had been bitten, he had fallen onto the concrete and was dragged into the water and then he shoved his other hand in its mouth to try and free his trapped hand."
Paramedic Hamdorf said the patient may need a few stitches to seal the wounds, and may have to visit the hand hospital for further treatment depending on the extent of the damage.
Mr Burton, believed to be in his mid 30s, was performing one of the regular crocodile feeding shows at the zoo at about noon on Monday.
Shortly after, the resident croc, a 3.7-metre male known as John, grabbed him by the hand and dragged him into the water in the enclosure in front of horrified spectators.
Shaken witnesses told how the handler managed to get free of the croc's grasp and get out of the water.
Witness Marlene Orr, from Shellharbour, said it was the scariest thing she had ever seen in her life.
"We saw the trainer taken by the crocodile," she said.
"I've seen them in the wild, lying on river banks and have seen them at Steve Irwin's Zoo, but never like this. It was too scary."
Albion Park resident Michelle Brady and her daughters Monique and Georgia also saw the attack.
"The trainer was feeding him meat and the crocodile took it before the designated area to be fed. The trainer tried to take it out of the crocodile's mouth and the croc just grabbed his hand and pulled him to the ground and dragged him into the water," she said.
"Then the trainer got free and got out of the water.
"He had puncture holes in his hand," she said.
Shoalhaven Zoo owner Nick Schilko said Mr Burton had been with the zoo working with the crocodiles for more than a decade.
"Of course we are disappointed the attack happened, but thankfully it doesn't appear to be too serious," he said.
"It's an attack and that is serious, but thankfully the injuries aren't life threatening, which it certainly had the potential to be.
"He's more disappointed with himself that it happened.
"He works with him (John) on a daily basis."
It's not the first time John, named after the former owner if the park John Stone, has latched onto the odd digit or two.
Mr Schilko had been bitten by one the zoo's star attractions.
"At this stage we don't know how serious the damage to his hands may be. He said he hasn't lost any fingers and thinks it would only require some stitches," Mr Schilko said.
He said the zoo would reassess its procedures.
"We will look at what happened and how it happened and review it," he said.
"We have procedures in place and they need to be followed.
"If the handler wants to get back involved with the big crocs, which I bet he will, I would be 100 per cent behind him," he said.
"Big John has been a resident of the park for more than 10 years and along with his female partner, Dawn, were named after the former owners of the zoo, John and Dawn Stone."
They are believed to be the southern-most pair of crocodiles to breed in an outdoor enclosure in the world.
South Coast Register


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I wonder where they sell that...
I wonder where they sell that...
not gonna change my profile picture
Ciao przemson! I continue to check back to this thread for the latest posts
of your work and I have yet to be disappointed. Pay no heed to those who
don't think it belongs here and keep up the great work!
59 Cadillac Eldorado
Nice reflections in the door! Very realistic!
Hero's come and go, but legends never die!
Pencils and Markers
Lamborghini Countach 5000S
Quick Porsche work
nice work. Looks great.
M5 f10
Aventador drawing
About 20 hours
Pencils and markers
Hope you like it
Where are the Ferrari's As for the paintings, you are really doing good, but a Lambo will always be uggly
amazing! can't wait for you to decide to love the LaFerrari !! i know it wont take long, just disregard those footage where you see some prince driving one and doing a laughable job at it.
In fact Ferrari's shouldn't just be sold for whoever can buy it, you must go through a series of tests, just like they wouldn't put bill Gates at Fernando's seat for next season. they shouldn't sell them to people who are just going to mess it up.
The art isn't in never falling but in always getting up.
Nissan GTR in 16x22
Pencils and markers
Nice GT-R again, but the exhaust pipe is sticking out a little bith to much.
Hero's come and go, but legends never die!
Nice GT-R przemson, it's one of the few Asian cars I really really like
Some more GTR
This one going to US
Hope you like it
Pencils and markers
Hope you like it


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Last week we got a sneak peek at the bikes Ritchey will show at this weekend's North American Handmade Bicycle Show (NAHBS) in Charlotte, NC. We were sworn to secrecy until the end of this week and get to show you one bike today and two tomorrow. First up—the new Ritchey Swiss Cross Disc.
Ritchey Global Marketing Director Sean Coffey assembles the company's first disc-compatible cyclocross frame—the Swiss Cross Disc in the company's workshop. Fillet-brazed by Tom Ritchey himself, this handmade prototype will serve as the "golden sample" for the production version of $1,300 frameset the company will start selling in August—just in time for 'cross season. It's made of Ritchey Logic II triple-butted steel tubing and includes Ritchey's new Carbon Cross Disc fork and a Ritchey Logic Headset.
Ritchey will also offer the carbon disc fork for sale with a matte carbon finish in a non-tapered version for $450.
"The fork has a straight steer tube that's plenty stiff and passes the CEN test protocol for disc brake forks," notes Coffey. "As a bonus this means folks with nice canti frames and non-tapered head tubes will have the option of running a disc fork/brake on the front—where it matters—and stick with canti's on the back for weight savings."
The bottom bracket of the Ritchey Swiss Cross disc is a study in minimalist beauty.
The rear caliper of the Ritchey Swiss Cross disc is intentionally tucked-in tight to prevent interference when running with the bike. Tubing in the area has also been reinforced to counteract the additional braking forces in the seatstays and chainstays.
A simple world champion stripes-on-black graphics scheme along with the Swiss Cross on the top tube gives the bike a certain understated elegance.
Coffey dials in the shifting on the Rotor crankset-equipped NAHBS show bike.
The NAHBS bike sports a pair of hydraulic TRP calipers that are cable actuated and can be used with standard brake levers.
The NAHBS show bike includes Ritchey's Vector monorail seatpost and saddle system Coffey says offers both lighter weight and better compliance than traditional systems.
Coffey takes stock of his show bike—Ritchey frame, Ritchey fork, Ritchey bars, Ritchey Stem, Ritchey pedals, Ritchey saddle, Ritchey seatpost, Ritchey wheels, Ritchey tires, Ritchey headset and—eventually—Ritchey bar tape.
For more information visit ritcheylogic.com.


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Are you a speed junkie? I wouldn't say that I generally am, but when I'm on a bike it's a totally different story. It's like the faster I'm going, the better I feel. I really think my mind was made to go the speed of a pro rider….now my body just has to catch up to actually deliver those speeds.
When I'm riding solo and pedaling along at speeds of between 28 and 32kph I'm okay with it, but when I'm rocking my upper speeds of 34 to 36kph I feel alive. When there is a tailwind or a decline and I'm flying along at 45, 55, and more kphs….even better.
But my need for speed only goes so far. On those rare rides when I'm at the top of a very big decent, I do find myself getting a little nervous as that speed starts creeping into the high 60's. As far as I can remember, the fastest I've ever gone was while coming down the hills of the St. Kitts Peninsula….somewhere in the neighbourhood of 70+kph. Maybe not that fast for a pro rider, but definitely fast for a punk like me.
I once heard Lance Armstrong say that the fastest he ever clocked himself at was close to 70mph….that's 112kph. Insane….even he said that it was. But going 50 to 60mph (80 to 95kph) on a decent is pretty much commonplace for a pro rider. Still very insane. Just a little too far off the register for this so called cycling speed junkie.
How about you? What's the fastest you've ever gone on a bike? What did it feel like? Would you do it again?


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Blubbie went tsk tsk tsk, while forging ahead in the secret garden, promises withstanding to arcturus (to whom this was a promise made in earnest)that gone are the days of simply staring at objects d'art, while sipping creme de minth or absinthe.
The ruins among those perplexing timeless escapes through internal struggles of inescapable dimensions, that Blubble merely scathing traced over, years of befuddled fanta sticks the boughs gently traced as if meaning to imply some veritable mystery, and him being a wizard, may expressly indulge, newly rebutting an escalating sense of breathlessness.
Course these noumina by known feelings become real manifests aspirations of long standing, breathed out mantra like into the vast expanse of the bolt of blue spread out sky ,as if nature prostratinf herself into a flattening gallery of fillagres of needlepointed bazzars of a bizarrely elongated mandala,
inviting , but a charismatic tapestry.
She asked him about the man who invented the instamatic Kodak camera and loosing 400 million through the great panic of 1929 he killed himself, but he still had 40 million left. Silly.
And Blubble lisping guttorally, from somewhere deep inside, as if to appraise the analogy as unfair or somewhat unbecoming.
Then he thinking of the short time left perhaps that he should not have gotten married, had this brew whom he cares and worries about constantly and the obsessional limmerick to be or not to be, constantly a haranging , to deal with it , and as IT approaches, the anticipation correspondingly increasing as well the pitch of double beats in the heart, wherein the unendurable weight mixes so smoothly with the lightness so seemingly matter of fact, with choirs of angles chorusing a sweet refrain.
In my room, even if its not mine and technically not even in it , Blubble mystified her, and ponderes the violation of a hard earned observance of a rule that has always been an unwritten law, don't drink before noon, and never without consuming some kind of snack.
Last night with the tyke Aiden, who now appears to be the current progenitor and keeper of what's left of his soul, of referring to him, she made a semi non forgivable slip of hers, that when he is gone nothing will be left to him, Aiden, the dear reincarnation of his young son who went out and quit the race at 33 years old.
What did she do all the many years together? Waste, with all projects, assets, inspired moment is down the drain, forever toying with ruin, as if accumulation ,merely a game like go or monopoly, of an underlying. deliberate deconstruction of the self.
The last imbroglio was with mama's house. For collection time immemorial, day of reckoning brought frantic efforts of recovery, the failure of that leading to certain foreclosure of two generations of hard acquisitive work, in the literal sense, oft finding legal notices tagged on to front door for all the neighberhood' s benefit: Notice to Quit. And it was supposed to be for her and Aiden, his future to have some kind of a. edge to overcome the vapid stench of demoralised barroom escapes intruding into his sense of yet untouched aspiration.
No. It was supposed to go to his mother her fittingly reminding him, of how anything to her or us would happen, he, the child wonder, his grandson as luminous as a little angel, will be defeated almost as certainly as the havoc sustaining such predictable effects causing by this general malaise.
So she went by the property the other day and having had experience in property said that the short sale-d property was torn down and two apartments with 30th units each was built there.
Imagine, she went on breathlessly, how how much buttress its subsequent effect on demoralizatipn of its retention may have caused to
save him?
Capital is future oriented for vanishing child-adolescent generational sustenance, but for some its merely a convenient rationalization to do away the depresdingly hanging clout of playing up to an overbearing inheritance, which is usually and typically blown away with a few hands of risky hold'em card game.
No trepidation there , merely a new game by the woman with 2 husbands. whose latest paramour , an immunologist with supposedly great business sense, using her impressionality to wit, as if she meant more to him then merely a present usable part in a subtle mechanism of opportunity opportunal deception.
For that, she is playing this game, a game which cannot be won , and Blubblie's excursions into the dark heart of the secret garden, by now become an excursion into the vast undertow of the ruins, laden with eternal song in the background of the maddening poetry of love, real love, emanating of Orpheus and deceived by the long spineless slumber by Morpheus, traveling through myriads of past and future times where at once, then or somewhere. he may through a long tunnel arrive only as looking down on an inert body, that at first, as Narcissus once did now, recognise at once : his own body.
The Ruins silently wait for your visit, in the secret garden of desire where the mingling of every one with deserving or undeserving ones, so that a new communal bath will clean and repatriate into that time and place, where the ruins were just built out of the clay and soul.


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Festool 50mm x 2.5m Anti-static Suction Hose D50 x 2.5m AS
Festool 50mm x 2.5m Anti static Suction Hose D 50 X 2.5 M AS
Festool's Antistatic hose design helps you work cleaner by preventing dust from accumulating on the exterior of the hose. It helps you work more safely by preventing static discharge or shocks. You'll work more efficiently with system that prevents clogging due to particulate buildup inside the hose. durable, pliable design withstands heavy use and prevents kinking, for longer service life and more efficient work. Includes: 50mm Antistatic hose with two rotating connector adapters.
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It feels great when bands are excited enough by their A.V. Undercover performances to give them an official release. You may have seen the Wye Oak 7" in the past, or the They Might Be Giants compilation that included "Tubthumping." Iron & Wine is the latest outfit to join that illustrious club: Available for pre-order today is the "Two Sides Of George" single, which includes I&W's cover of George Michael's "One More Try" (from their Undercover session) as well as a cover of Little Feat's "Trouble" (by Lowell George, hence the title of the single). The record is limited to 750 copies worldwide, and is available for preorder right here. Below you'll find "One More Try" in all its video glory. Enjoy!
More from The A.V. Club


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Early next year, devotees of the Toyota Prius will have their chance to go a step further into greenness. That's when the Prius PHV, a plug-in hybrid based on the current Prius architecture, will be introduced.
(To see related content, about the Chevy Volt, go to Drive for Innovation and follow the cross-country journey of EE Life editorial director, Brian Fuller. On his trip, sponsored by Avnet Express, Fuller is driving a Volt across America to interview engineers.)
Design News recently had an opportunity to drive a pre-production version of the Prius plug-in, and the good news is that it's a sensible alternative-fuel vehicle.
First, it should be noted that, as a plug-in, this Prius is half hybrid and half electric. It differs from other plug-in vehicles in that it employs a relatively small battery. At 5.2kWh, the Prius has a battery capacity that's about one third that of the Chevy Volt's 16kWh and about one fifth that of the Nissan Leaf's 24kWh.
There are pluses and minuses to Toyota's strategy. First, let's look at the downside: The Prius has an all-electric range of just 13 miles. If you're looking for a vehicle that's more electric and less hybrid, this isn't it.
The upside, though, is big. Yes, the range is just 13 miles, but the smaller-battery strategy has efficiency written all over it. Smaller means less mass, which translates into greater fuel economy. That's particularly important when the driver has exceeded the 13-mile range and the depleted battery is basically dead weight.
It also means the recharging time is a fraction of what we're hearing from competitors. Instead of an eight-hour recharge at 220V (as is the case with the Leaf), the Prius plug-in recharges in about three hours at 110V or 1.5 hours at 220V.
The 110V recharging setup is a huge advantage, not only in terms of availability, but also in terms of cost. During the week we tested the vehicle, we recharged in three hours twice from a 110V outlet. That's very important in terms of cost, because it means owners don't need to get their garages rewired at $2,000 a pop.
The biggest advantage of the smaller battery, however, is initial cost. Toyota engineers told us that more range would have translated into about $500 per design mile. Here's another way to look at it: Numerous estimates have placed lithium-ion battery cost at between $750 and $1,000 per kilowatt-hour. In terms of initial cost, that converts to between $15,000 and $20,000 to get an extra 20kWh.
During our test drive, we got the advertised 13-14 miles of range. When we drove within that all-electric range, our vehicle estimated its own fuel efficiency at 99mpg. It should be noted, however, that even when we drove within the electric range, the vehicle autonomously shifted back and forth between electric and hybrid modes. The main reason was acceleration. When we stepped deep into the accelerator, the car shifted into hybrid mode for about 10 seconds until a constant velocity was reached, and then it switched back. After a low-speed, 4.3-mile circuit, the vehicle's dashboard display claimed it had been in EV mode 75 percent of the time and in hybrid mode for the remaining 25 percent.
A longer drive was a different matter. As soon as we reached 60mph on a local expressway, the car shifted into hybrid mode and stayed there. The shift was seamless. During a 155-mile ride, the vehicle was in all-electric mode just 4 percent of the time. The fuel efficiency was still impressive, however, coming in at 56.6mpg.
The key to this car's success on the market, of course, will be its cost. Unfortunately, Toyota hasn't announced an exact figure. During an interview with Design News, Toyota engineers hinted at a possible figure hovering at around $26,000 or $27,000. But it's probably safe to say the ultimate entry number will be higher -- possibly landing between $27,000 and $32,000 before tax credits.
The bottom line is that this is a sensible alternative-fuel vehicle for someone who has a short commute to work. Some owners will be able to drive all week in the electric mode simply by recharging every night. Then, when the weekend arrives, they can depend on the car to switch silently to hybrid mode for greater range.


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This luxurious hotel provides great views of the Bellagio fountains. It has a choice of pools to relax by, as well as some unique and intriguing facilities.
For the ultimate experience, head to the adults-only Marquee Day Club Pool at The Cosmopolitan of Las Vegas, fitted with cabanas. At night, this transforms into the large and popular Marquee nightclub. Enjoy exclusive access to the best of STK, Beauty & Essex, CliQue Bar & Lounge, Marquee Nightclub and more every Monday. The Boulevard Pool overlooks the strip, or the Chelsea Pool is perfect for a relaxing afternoon.
The individually decorated accommodations are residential style rooms. They feature large living spaces with private terraces that overlook the world famous Las Vegas Strip.
Sample the 18 different restaurants offering a mix of worldly cuisine. Unique facilities include a bar set within a chandelier, a secret pizza restaurant, unconventional concerts and dive-in movies, where you watch Hollywood films around the pool. Chandelier Bar is created by luminous beaded curtains of light, this provides a playground and art exhibit all in one. The top offers a lounge showcasing the splendour, the inside is a cocktail haven and the bottom is a high-energy casino bar.
Pamper yourself in the Sahra Spa, Salon & Hammam, previously listed on Conde Nast Traveller's Hot List, or indulge in a nail, hair or beauty treatment. Or lose yourself in the 100,000 square-foot casino voted Best Casino by USA Today.
Accommodation details
3708 S. Las Vegas Blvd
Las Vegas
Check-in Details:
Normal Check-in: 15:00
Normal Check-out: 11:00
0.3 mi / 0.6 km from city centre
General facilities
- Valet parking
- 3 Pool
- Health club
- Live entertainment
- Pool Bar
- Spa
- Exercise gym
- Non-smoking rooms (generic)
- Internet services
- Hairdresser/barber
- Tennis court
- Hair dryer
- Casino
- On-Site parking
- Steam bath
- Outdoor pool
- Dry cleaning
- Safe deposit box
- Business center
- Sauna
- Jacuzzi
- Nightclub
- Beauty shop/salon
- Ironing board
- Laundry/Valet service
- Room service
- Currency exchange
- 5 Lounges/bars
- Onsite laundry
- 13 Restaurant
- Shop
Other facilities
Opium Theatre - the new show from the creators of Absinthe. A fast, funny and funky display showcasing a pack of comedians and crooners in front of the house band.
The Chelsea centre for concerts.
Dining information
• Block 16 Urban Foodhall - a first of its kind on the Las Vegas Strip, the made-to-order, fast-casual concept features a dynamic lineup of restaurants handpicked from foodie capitals across America. Restaurants include the hip and widely popular New Orleans restaurant, District: Donuts. Sliders. Brew. Nashville's hot Southern chicken joint Hattie B's Hot Chicken, Portland chef Rick Gencarelli's over-the-top sandwich eatery Lardo, James Beard Award-winning Chef Andy Ricker's Pok Pok Wing from Portland, and Tekka Bar: Handroll & Sake, an original Japanese handroll and sake concept from locally acclaimed Las Vegas restaurateur, Takashi Segawa. Ghost Donkey, a hotspot tequila and mezcal cocktail bar from New York City will complete the collection later in 2018
• Beauty & Essex - sharing plates and cocktails in a speakeasy setting
• Blue Ribbon Las Vegas - award-winning cuisine from Eric and Bruce Bromberg
• China Poblano – Chinese and Mexican
• E by Jose Andres - a small, quiet room opposite Jaleo's
• Eggslut - classic comfort, based on egg ingredients
• Estiatorio Milos – fresh seafood, a unique restaurant experience encase in a glass space
• The Henry – classic Vegas cuisine
• Holsteins – homemade American burgers and sausages, with tasty shakes and sides
• Jaleo – exciting Spanish tapas
• Overlook Grill – fancy American cuisine and home-brand coffee
• Rose. Rabbit. Lie - modern supper club that offers up reinvented American favourites, with live music and entertainment
• Scarpetta – Italian restaurant
• STK – classic American steakhouse and bar, offering a sexy atmosphere and flirty bar
• Wicked Spoon – food hall with traditional and seasonal dishes
• Milk Bar - bakery, ideal for desserts, snacks and local dairy
• Momofuku - globally inspired dinner restaurant, featuring noodles, seafood, meat and steamed buns, great for sharing
• Zuma - enjoy modern Japanese cuisine and celebrated cocktails in an elegant environment
• Red Plate - a sophisticated dining concept that celebrates traditional Chinese cuisine in a refined setting
• Room service – special menu.
Additional information
In response to Coronavirus (COVID-19) the Wicked Spoon restaurant will be open Thursday to Sunday from 08:00 to 15:00. Red Plate and Ghost Donkey will remain closed until further notice, and Estiatorio Milos will be closed from 25 October. Please be aware that bar and restaurant opening hours may be subject to change. Public spa facilities such as the steam room will remain closed until further notice, however treatments are available with a reservation.
A compulsory facility fee is payable locally and includes the following: complimentary self- and valet parking, unlimited local, toll-free, and domestic long distance telephone calls (all 50 states), 24-hour fitness center access and tennis court access (based on availability).(All inclusions may be subject to change.)
# night(s) ---
from #,###pp


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Ready to Schedule a Tour?
Our desire is to make you feel comfortable and confident in your decision to place your child in our care. Parents should complete our Inquiry Form if interested in scheduling a tour. Upon receipt of the completed no-obligation form, one of our staff members will call you to set an appointment for a tour of the school.
Ready to Enroll?
If you have already visited Mill Avenue and would like to begin the enrollment process, you can find all the information you need in our Enrollment Information Packet. The packet provides you with a checklist of what you need to bring, along with the forms you will need to get started. Simply print them and fill them out, then bring them with you for your pre-enrollment conference.


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Hubble's view of Cigar Galaxy on sixteenth mission anniversary
To celebrate the NASA-ESA Hubble Space Telescope's 16 years of success, the two space agencies are releasing the sharpest wide-angle view ever obtained of Messier 82 (M82), a galaxy remarkable for its webs of shredded clouds and flame-like plumes of glowing hydrogen blasting out from its central regions.
Located 12 million light-years away, M82 appears high in the northern spring sky in the direction of the constellation Ursa Major, the Great Bear. It is also called the 'Cigar Galaxy' because of the elongated elliptical shape produced by the tilt of its starry disk relative to our line of sight.
As shown in this mosaic image, M82 is a magnificent starburst galaxy. Throughout its central region young stars are being born ten times faster than they are inside in our Milky Way Galaxy.
These numerous hot new stars not only emit radiation but also charged particles that form the so-called stellar wind. Stellar winds streaming from these stars combine to form a galactic 'superwind'.
The superwind compresses enough gas to trigger the ignition of millions more stars and blasts out towering plumes of hot ionised hydrogen gas, above and below the disk of the galaxy (seen in red in the image).
In M82 young stars are crammed into star clusters. These then congregate by the dozen to make the bright patches or 'starburst clumps' seen in the central parts of M82. The individual clusters in the clumps can only be distinguished in the ultra-sharp Hubble images.
Most of the pale objects sprinkled around the main body of M82 that look like fuzzy stars are actually star clusters about 20 light-years across and containing up to a million stars.
The rapid rate of star formation in this galaxy will eventually be self-limiting. When star formation becomes too vigorous, it destroys the material needed to make more stars. So the starburst will eventually subside, probably in a few tens of millions of years.
The observation was made in March 2006 with the Advanced Camera for Surveys' Wide Field Channel. Astronomers assembled the six-image composite mosaic by combining exposures taken with four coloured filters. These capture starlight from visible and infrared wavelengths as well as the light from the glowing hydrogen filaments.
Note to editors:
The Hubble Space Telescope is a project of international cooperation between ESA and NASA. It was launched on 24 April 1990, aboard the space shuttle Discovery.
For more information:
Bob Fosbury
Hubble/ESA (ST-ECF), Garching, Germany
Tel: +49 89 3200 6291
E-mail: rfosbury @ eso.org
Lars Lindberg Christensen
Hubble/ESA (ST-ECF), Garching, Germany
Tel: +49 89 3200 6306
Cellular: +49 173 3872 621
Email: lars @ eso.org
Jay Gallagher
University of Wisconsin, USA
Tel:+1 608 263 2456
Email: jsg @ astro.wisc.edu
Ray Villard
Space Telescope Science Institute, Baltimore, USA
Tel: +1 410 338 4514
Email: villard @ stsci.edu


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Creekside Theatre Fest's TWELFTH NIGHT has potential
CEDAR HILLS – Summertime Shakespeare has become a mainstay of Utah theater, but in these...Read More
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by Christian Cragun | Jul 21, 2020 | Reviews, Utah County | 0 |
CEDAR HILLS – Summertime Shakespeare has become a mainstay of Utah theater, but in these...Read More
by Russell Warne | Mar 19, 2016 | Reviews, Utah County | 0 |
PROVO — After over a decade of following an army in wartime, Mother Courage says, "I'm...Read More
by Christian Cragun | Nov 20, 2014 | Reviews, Utah County | 0 |
PROVO — See How They Run by Philip King is a classic farce about the Toops, a vicar and his...Read More
by Anne Flinders | Feb 19, 2014 | Reviews, Utah County | 0 |
PROVO — "One has to be serious about something if one is to have any amusement in life."...Read More
#SaltLakeActingCompany #SLAC #SLACDigitalShorts #SLAC4934 #Quarantine #Pandemic #SociallyDistanced #Coronavirus #Covid19 #DigitalShorts #Shorts #Comedy #Parody #Online #UtahTheatre #UtahArts #utpol #AmericanTheatre
#UtahTheatre 👀
IS the 8-shows-a-week model really good or healthy for anyone in theatre? The fatigue, steroids, caffeine, constant risk of injury shouldn't be so normal even if if the payoff is doing something you love. The Business of Broadway is just as dangerous as any other big business
Join the revolution! Matilda Jr classes start in January. All students are cast in the full production.
Enroll at http://www.onpitchperformingarts.com/tickets2.html
#OPPA #TheatreMatters #KidsMatter #GetInvolved #Theatre #UtahTheatre #CommunityMatters
This is a great show! Check it out. #utahtheatre
Hours from opening, got your tickets yet??? You can watch from anywhere!
#newplay #zoomplay #playwrightlife
Read Alissa Frazier's review of @HCTO's production of SENSE & SENSIBILITY. This adaptation of the timeless Jane Austen classic plays through November 21. #utahtheatre
New review by @Theatre_Critics member @Russwarne for @LehiCity Arts Council's BIG FISH, a #utahtheatre show delayed twice because of #COVID19.
#intermission at @LehiCity Arts Council's BIG FISH. According to the preshow announcement, this cast started rehearsing in January and was almost ready to open when the pandemic hit. So, it's a long time coming. #utahtheatre
I'm with my wife at @LehiCity's BIG FISH. Look for the review later on @UtahTheatreBlog! #utahtheatre
you'll notice the theatre kids are not complaining about wearing a mask bc 1. whining about wardrobe is a big no no and 2. you know there's no point since you'll have to wear it anyway
#utpol #UtahTheatre @SenMikeLee @SenatorRomney
Daily arts holler: arts sector and freelancers here. Still here. Adrift. Anyone?
Check out our review by @UtahTheatreBlog! Only three more chances to see Last Train to Nibroc at our outdoor drive-in theater this weekend! https://utahtheatrebloggers.com/85998/punch-your-ticket-for-the-last-train-to-nibroc-at-aotc
New #utahtheatre review written by @Theatre_Critics member @MarenSwensen for @CPT_Theatre's BROADWAY VILLAINS IN CONCERT. This is the first production we've reviewed where actors were face shields while performing. Read the review to learn more.
Here's the review.
Many non-critics don't realize that writing a review is itself a creative act. Reviews are a genre of literature. It's hard to hit that literary style when writing quickly under a tight deadline, but I always try. #utahtheatre #2amt
Read @Theatre_Critics member @Russwarne's review for the theatre for young audiences production of HOW I BECAME A PIRATE, playing now at @SCERAupdate. #utahtheatre
Here I am again with my junior theatre critics. We're seeing @SCERAupdate's HOW I BECAME A PIRATE. Look for the review later on @UtahTheatreBlog! #utahtheatre
I directed a play. It's safe to watch and for all those participating as it's a drive-in and the two actors live together. It just got a great review and its back this weekend. I think you should see it if you can. 💜
Read @TaraNicoleHaas's lovely review of a lovely show, @AnOtherTheater's LAST TRAIN TO NIBROC. This is a #utahtheatre production you can safely watch from your own car in #Provo.
#utpol #UtahTheatre @SenMikeLee @SenatorRomney 👀
Strip all in Congress of their salaries and benefits and see if they understand what it feels like to wait for a stimulus package
#utpol #UtahTheatre
I understand it's a challenging place to be. AND. THIS is when you get to exercise your *accomplice* muscle (note this is different than allyship).
👉 Are you willing to *break unjust laws* in order to uphold your commitment to equity and justice for all? 👈
#utpol #UtahTheatre
I think I need to put this as plainly as I can, and I apologize for shouting: PEOPLE WHO WORK IN THE LIVE PERFORMING ARTS AREN'T JUST 'NOT WORKING' – THEY ARE *PREVENTED* FROM ENGAGING IN THE WORK AND CAREERS FOR WHICH THEY WERE TRAINED.


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Observation and Natural Theology: William Harvey & William Paley
In the 1600s the study of life changed forever. After relying on the authority
of ancient writers like Aristotle and
Galen for centuries, European naturalists
began to look at life for themselves. Anatomists discovered new organs
in the human body, and also discovered that familiar organs didnt
work the way Aristotle and Galen said they did. The English physician
William Harvey (above left), for example, discovered in the early 1600s that blood
was pumped from the heart through the body in a closed loop. Meanwhile,
Harvey and others were examining animals and plants and making equally
astonishing discoveries. The English inventor, Robert Hooke,
for example, looked through a microscope at a previously unimaginable complexity hidden
in tiny animals as humble as a flea.
Envisioning organisms as machines
This new generation of naturalists envisioned life as machines. Like human-made
machines, an animal had many different partsmuscles, eyes, bones,
organs, and so onthat all played vital functions to help keep the
animal alive. Naturalists found that they could apply the same scientific
methods in physics that they used to invent machines, to life itself.
Natural theology and Gods design
Some clergymen worried that this mechanistic approach of life smacked of atheism. But many of the naturalists
themselves believed that they actually were on a religious mission. In fact, a number of them were both
naturalists and theologians. They believed that God had created the entire world in such a way that
his plan could be understood in part by rational creatures. By studying the intricate structures of a hand
or a feather, a naturalist could appreciate Gods benevolent design.
Natural theology, as it became known, dominated English thinking for nearly two centuries. In the early 1800s,
it was best known to Englishmen through the writings of Reverend William Paley (left). Natural
theology was important scientifically because it guided researchers to the fundamental question of how life
works. Even today, when scientists discover a new kind of organ or protein, they try to figure out its function.
But it would be Charles Darwin, who actually
occupied Paleys rooms at Cambridge University and was an admirer of Paleys work, who would take
science beyond natural theology and move those questions from the religious sphere to the scientific.
Read how others have recognized the Understanding Evolution website.


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Antarctic Circle
Antarctic Circle, imaginary circle on the surface of the earth at 66 1⁄2 °S lat., i.e., 23 1⁄2 ° north of the South Pole. It marks the southernmost point at which the sun can be seen at the winter solstice (about June 22) and the northernmost point of the southern polar regions at which the midnight sun is visible.
The Columbia Electronic Encyclopedia, 6th ed. Copyright © 2012, Columbia University Press. All rights reserved.
See more Encyclopedia articles on: Antarctic Physical Geography


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I noticed that Canon put up the retail prices for the Canon 5D Mark II accessories. Holy smokes! I had to double check to make sure I wasn't on the Canon Australia website. Sure enough though, it's US dollars.
Check these out:
- Battery Charger LC-E6 – $80 (it's a freaking battery!)
- Battery Pack LP-E6 – $100 (are you kidding me?)
- Battery Grip BG-E6 – $380 (the current price of a Rebel XT)
- Car Battery Charger CBC-E6 – $270 (isn't this just a battery charger with a different cable?)
I'm a big fan of battery grips, but come on . . . $380!?! Granted these are retail prices, but these are still off the charts for retail.
I suppose Canon is making the most out of that attractive price point for the 5D Mark II body. Well, maybe we're just a couple days or so away from when you can put all these fancy accessories on your new 5D Mark II.
Who's going to get in line for these accessories? Which ones are must-haves?


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7 Exercises to Tone Your Oblique Muscles
Want those V-shape abs you see on the cover of fitness magazines? Add these exercises to your routine.By Cat Perry
How to Go From Zero to Marathon in Six Months
If you're a marathon newbie or have been out of the game for a while, you need a smart training approach to get on the 26.2-mile sBy Pete Rea
The Best Holiday Gifts for Women Who Run
Whether you're looking to treat someone to a big-ticket item or searching for a little something for the run club gift exchange, wBy Megan Harrington
33 Basketball Terms Every Kid Should Know
Before your child takes the court for the first time, make sure they're familiar with some basic basketball terms all players shouBy Hunter Hewitt
How to Train for Your First IRONMAN
Are you ready for 140.6 miles of racing? Expert Gale Bernhardt explains what to expect when training for your first IRONMAN.By Gale Bernhardt
11 Fun Basketball Games for Kids Besides H-O-R-S-E
No matter your child's skill level or shooting ability, he or she is sure to have fun playing one of these five basketball games.By Brian Kendall and Angela Bekkala
12 Ways to Build Ankle Strength for Top Performance
Paying attention to your ankles will benefit your overall athletic performance in the long run. Here are 12 ways to build strong,By Stana Landon
30-Minute Bodyweight Tabata Workout
All it takes is 30 minutes and some space to do this full-body HIIT workout. No equipment necessary.By Hunter Hewitt
14 Running-Specific Strength Training Exercises
Strength work is the backbone of great endurance training. These running-specific exercises will help you build strength, agilityBy Nikki Chavanelle
2-Week Workout Plan to Lose Inches
Make your fitness goals a reality. Take on this two-week workout plan to lose weight, build muscle and gain endurance.By Joe Vennare
No results were found for "Hockey in Beverly, MA"


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Hudspeth County, TX, U.S.A. Community Webpage
Click Here To Advertise for just $10
10/31/2020 UPDATE: Revenue sharing positions are still available for Hudspeth County online editorial staff, writers and video or photo hobbyists throughout our local communities. You don't even have to fill out a resume to get this job as all you have to do is submit and start earning from your hudspeth community content.
The growth in quality content and features for this site depends on the level of participation and usage, so when you tell your neighbors and friends about our service, the more people from our hudspeth towns who come online, which will resut in greater features and greater earnings potential for your submissions.
Take A Look At Our Hudspeth County Local Web sites
Click Here for More Hudspeth County News
The F.I.P.S. code is 48229.
Latitude: 31.8776, Longitude: -105.2645.
There are more sites for other counties and towns across the State of Texas available.
In fact, we host pages for every State, County and Town in the U.S.!


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Story highlights
- Police say the incident is related to a traffic altercation, not a football rivalry
- One victim is listed in critical condition, two in stable condition
- It is unclear what caused the scuffle
- It happened after the Denver Broncos lost their Thursday night game
A late-night scuffle after the Denver Broncos-San Diego Chargers game, which left at least three people with stab wounds, appears to be over a parking space rather than a football rivalry, police said Friday.
Police took three people into custody, and two have been released pending further investigation, Denver Police Sgt. Steve Warneke said Friday.
Justin Manzanares, 29, is being held for investigation of three counts of aggravated assault.
A fourth person also may have been injured in the Thursday incident in the parking lot next to Sports Authority Field at Mile High, but authorities have yet to find that victim, Warneke said. That person left without seeking treatment, according to authorities.
The three victims are now in stable condition after suffering non-life-threatening injuries, he said.
"It doesn't appear that this was related to the outcome of the game. It doesn't appear that this was Broncos versus Chargers. It appears this stemmed from a traffic altercation in which the suspects were backing out of a parking space and nearly struck the victims' vehicle," Warneke said of the 10 p.m. (12 a.m. ET) incident.
The Denver Broncos referred questions to Stadium Management Company, which runs the team's stadium. The company said it was aware of the incident and was working with authorities.
This is second violent incident after a Broncos game this month.
A 30-year-old man died after he fought another person in a parking lot near the Kansas City Chiefs' Arrowhead Stadium on December 1. That incident happened after a game between the Chiefs and the Broncos.


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Select Region:
Travel Sales Consultants - Leisure and Corporate Travel - £40K OTE +
|Job title:
|Travel Sales Consultants - Leisure and Corporate Travel - £40K OTE +
|Contract type:
|Tour Operators
|Contact name:
|Tony Yerasimou
|Contact email:
Travel Sales Consultants - Leisure and Corporate Travel - Base Salary - £20,500 Earn over £40k + Uncapped – Croydon
My client is one of the UK's leading sales companies who are specialists in selling travel to both leisure and business travelers to worldwide
They are seeking to employ dynamic, self starting money motivated travel sales consultants who can demonstrate a steady employment record and their achievements in hitting targets.
Travel sales experience is not essential but the experience gained in a targeted sales environment to develop rapport with clients gained and close sales is!
As a Travel Sales Consultant you will undertake an array of tasks & responsibilities:
Booking all aspects of travel for leisure and business clients
Up-selling and adding on of ancillary products including car hire, insurance, airport parking, etc...
Proactively developing a client base through good customer service, networking and referrals
Meeting and exceeding set sales and performance targets
Travel Sales Consultants remuneration and benefits package:
Basic of £20,500 + commission, realistic OTE of £40k uncapped
Lucrative competitive commission structure
25 days holiday
Concessions on holiday offers
Travel Sales Consultant skills and experience required:
Previous sales experience in any industry with an interest in travel is essential, money motivated graduates will also be considered
Good clear telephone manner, rapport and closing skills
Flexibility to shift patterns as the sales operation is open on weekends and bank holidays
There is a 4 week paid training course which is assessed prior to going live on the sales floor.
The induction start date is the 4th November 2019
Please contact Tony on 0207 812 3820 or email your CV to firstname.lastname@example.com
Expired job
Get similar jobs like these by email
By submitting your details you agree to ourT&C


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Over 130k travelers like you have chosen Tripaneer so far. Hear what they have to say about us!
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Aching for a rejuvenating and energizing escape? If so, then we invite you to try a healing detox holiday! Most packages include pampering massages, relaxing yoga sessions, and the freshest, healthiest, and most delicious of foods. Get ready to heal your body's imbalances and boost your immune system and energy levels. But most importantly, you will start creating healthy habits that you can bring back home with you. So, book your detox holiday today and change your life!
It's the same old question that's been asked over and over again. How do we lose weight? And more importantly, how do we keep the weight off? Much of weight loss is perseverance and motivation, but there are some useful tips that we can apply to help make the process more effective and less painful!
New year, new habits, new weight loss plans. For many of us, without fail, the first months of the year remind us that we should do something to improve our wellbeing. And, most often, that "something" is losing weight.
If you want to lose weight but just can't do it due to heavy consumption of calories and cholesterol, then this post is the saving grace you need. Detox juices might be what you've been waiting for!
Change is not easy. And if this is a change for better, it is going to be even more difficult. For example, eating healthy is considered a good habit. You realize the benefits of eating only fresh, organic products, but sadly, you have never been able to accomplish this mission even after countless resolutions. And if you have succeeded, only you can understand what it takes to establish a good habit.
Over 130k travelers like you have chosen Tripaneer so far. Hear what they have to say about us!
through Tripaneer
recommend booking with us
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"Everything and everyone was absolutely first class. "
"In an amazing setting three remarkable women guide you to recharge your body, mind and soul. I'll be back next year🌸"
"Everything from location, staff, classes, room and food"


text:
Dellthe world's second-biggest personal computer maker, expects its growth to outrun the overall industry's, with Asia leading the trend, founder and CEO Michael Dell said on Tuesday.
We expect to continue to grow faster than the industry, particularly in Asia," Michael Dell told a news conference during a visit to South Korea to meet clients and suppliers.
"When you look at our business now, growth is pretty consistent with fourth-quarter levels," he said, adding: "Asia Pacific is certainly a big part of that group."
In the quarter to Feb. 1, Dell's laptop computer revenue rose 24 percent and revenue from server computers, data storage gear and desktop computers increased by 2 percent.
"The consumer side is expanding very dramatically," Dell said. "Laptops are a big driver for here and all over the world."
Dell is more dependent than rivals Hewlett-Packardand International Business Machineson the United States, whose economy is on the brink of recession. Dell generates about half of its revenue in the United States.
"Our business in Asia-Pacific and Japan grew by 41 percent," Michael Dell said, referring to the company's unit sales growth during its latest fiscal quarter.
The company lost the top market-share spot to HP in 2006 as consumers favoured buying notebook PCs in stores, where HP has had an advantage.
Dell is also facing increasing competition from Asian rivals, including Acer and Lenovo Group.
Dell last year abandoned a long-standing direct-only sales model and started selling PCs in retailers including Wal-Mart Stores and Best Buy in North America, Carrefour in Europe and China's GOME Electrical Appliances Holding.
Michael Dell said the company is expanding retail relationships and sees "more retailers signing up."
"For direct (sales), we will continue to grow that portion as well," he also said.
Michael Dell delivered a soothing assessment on the market for computer memory chips, which has struggled with oversupply and steep price drops for more than a year.
"DRAM (dynamic random access memory) demand is growing quite fast," Michael Dell said, citing rising use of the Windows Vista operating system.
Rivals including HP and Apple have benefited recently from falling prices for computer components such as memory, monitors and disc drives.


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WASHINGTON — One of the big topics on Capitol Hill last week was the ongoing investigation into the attacks on U.S. facilities in Benghazi, Libya. And members of Maine's congressional delegation — including one who isn't even an official member yet — were in the thick of the discussion.
Maine's two Republican senators, Susan Collins and Olympia Snowe, serve on Senate committees that are probing the September attacks that killed Ambassador J. Christopher Stevens and three other Americans.
Collins made headlines Tuesday morning when she said it was "absolutely imperative" that former CIA Director David Petraeus testify to Congress, despite his recent resignation amid a scandal over an extramarital affair. Petraeus appeared before congressional committees late in the week.
But Collins also made news when she said a Watergate-style investigation was unnecessary and, in the process, appeared to "ding" fellow Republican Sen. John McCain, of Arizona, for missing a closed-door briefing on Benghazi. McCain was holding a news conference on his desire for a special select committee during the briefing to the Homeland Security and Governmental Affairs Committee.
NBC reported that McCain "made his displeasure to Collins known" the following day. And Collins later clarified her earlier, "inartfully" made point.
"All I was trying to point out is that he's a very valuable member of our committee, so he would be involved in all the briefings, the hearings and investigation," Collins told NBC. "And thus, I don't think that it's necessary to create a whole new separate committee. Our committee has a history of doing independent, bipartisan, comprehensive across-the-board investigations."
Maine Sen.-elect Angus King, meanwhile, added his thoughts on whether Susan Rice's statements on Benghazi should disqualify her for the secretary of state job. McCain and other Republicans have vowed to oppose Rice, the U.S. ambassador to the United Nations, over the statements suggesting the attacks may have been tied to protests over an anti-Islamic video.
"I watched some of those comments yesterday and I don't really like starting out my Senate career — I'm not even sworn in yet — getting crosswise with some of the leaders of the other party. But I thought it was a bit premature," King, an independent, said on MSNBC's "Morning Joe" program.
Snowe was slated to talk about Benghazi on CBS' Sunday morning news program, "Face the Nation" with Bob Schieffer. Snowe participated in several closed-door briefings on Benghazi in recent days as a member of the Senate Intelligence Committee.
Earlier in the week, Snowe was withholding judgment on whether a select committee was necessary. But she was critical of the lack of answers or progress on bringing the attackers to justice.
In the mid-1980s, Snowe helped develop legislation that established the U.S. Bureau of Diplomatic Security and the U.S. Diplomatic Security Service to oversee security of State Department facilities worldwide following a surge in attacks on U.S. facilities abroad.
"But, frankly, it's inconceivable to me that we would not have provided the necessary resources to provide for the protection and defense of that consulate," Snowe told the Portland Press Herald. "That was the purpose of the initial law creating the bureau to begin with because we had a lapse in security that ultimately led to attacks on our embassies and on our men and women."
In search of lost records
U.S. Rep. Mike Michaud, D-2nd District, is asking leading defense officials for answers to how the military lost, destroyed or failed to keep combat records for many incidents in Iraq and Afghanistan.
Such records can provide important documentation for veterans later seeking treatment from the Department of Veterans Affairs. A joint investigation by ProPublica and The Seattle Times found lax record-keeping for some units in the two wars.
In a letter sent Friday to Defense Secretary Leon Panetta and VA Secretary Eric Shinseki, Michaud asked for information on how the departments plan to address the loss of the records and on steps being put in place to ensure proper record-keeping.
"Our service members and veterans depend on your agencies and Congress to protect them in battle and to care for them at home," wrote Michaud, a member of the House Committee on Veterans' Affairs. "We cannot allow these lost records to lead to the same gaps in knowledge and care that our Vietnam veterans face with Agent Orange and our First Gulf War veterans face with medically unexplained illnesses."
Court limbo
Now that the presidential race is over, Maine's two senators are urging Senate leaders to take up a Maine federal judicial nomination that has been stalled for months due to election-year politics.
Senate Republicans have blocked votes on circuit court judgeships since the summer under a decades-old "rule" that has been employed by both parties when they were in the minority. The theory behind the so-called "Thurmond Rule" is that if the party's presidential nominee wins the White House, the new president would likely nominate a different person for the post.
Cape Elizabeth attorney William Kayatta, who was nominated for the 1st Circuit Court of Appeals, is one of the individuals stuck in political limbo.
Maine Sens. Olympia Snowe and Susan Collins — both Republicans — had bucked their party leadership and voted in July to move forward with circuit court nominations. Last week, the pair called on Senate Majority Leader Harry Reid, D-Nev., and Senate Minority Leader Mitch McConnell, R-Ky., to take up the judicial nominees.
"The First Circuit bench is small — it has only six active judges — so any single vacancy hits it disproportionately hard," Collins wrote in a letter to Reid and McConnell.
"In short, there is simply no good reason for his nomination to remain on the Executive Calendar when the Senate could easily and quickly confirm him to fill a vacancy on the nation's smallest circuit court of appeals," Snowe wrote in a separate letter.
Washington Bureau Chief Kevin Miller can be contacted at 317-6256 or at [email protected]
Twitter: @KevinMillerDC
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From Middle English schelle, from Old English sċiell, from Proto-Germanic *skaljō, from Proto-Indo-European *(s)kelH- ("to split, cleave"). Compare West Frisian skyl ("peel, rind"), Dutch schil ("peel, skin, rink"), Low German Schell ("shell, scale"), Irish scelec ("pebble"), Latin silex ("pebble, flint"), siliqua ("pod"), Old Church Slavonic сколика (skolika, "shell"). More at shale. Doublet of sheal.
- (computing): From being viewed as an outer layer of interface between the user and the operating-system internals.
shell (plural shells)
- A hard external covering of an animal.
- The calcareous or chitinous external covering of mollusks, crustaceans, and some other invertebrates.
- In some mollusks, as the cuttlefish, the shell is concealed by the animal's outer mantle and is considered internal.
- Genuine mother-of-pearl buttons are made from sea shells.
- (by extension) Any mollusk having such a covering.
- (entomology) The exoskeleton or wing covers of certain insects.
- The conjoined scutes that constitute the "shell" (carapace) of a tortoise or turtle.
- The overlapping hard plates comprising the armor covering the armadillo's body.
- The calcareous or chitinous external covering of mollusks, crustaceans, and some other invertebrates.
- The hard calcareous covering of a bird egg.
- One of the outer layers of skin of an onion.
- The restaurant served caramelized onion shells.
- (botany) The hard external covering of various plant seed forms.
- The covering, or outside part, of a nut.
- The black walnut and the hickory nut, both of the same Genus as the pecan, have much thicker and harder shells than the pecan.
- A pod containing the seeds of certain plants, such as the legume Phaseolus vulgaris.
- (in the plural) Husks of cacao seeds, a decoction of which is sometimes used as a substitute or adulterant for cocoa and its products such as chocolate.
- The covering, or outside part, of a nut.
- (geology) The accreted mineral formed around a hollow geode.
- (weaponry) The casing of a self-contained single-unit artillery projectile.
- (weaponry) A hollow, usually spherical or cylindrical projectile fired from a siege mortar or a smoothbore cannon. It contains an explosive substance designed to be ignited by a fuse or by percussion at the target site so that it will burst and scattered at high velocity its contents and fragments. Formerly called a bomb.
- (weaponry) The cartridge of a breechloading firearm; a load; a bullet; a round.
- (architecture) Any slight hollow structure; a framework, or exterior structure, regarded as not complete or filled in, as the shell of a house.
- A garment, usually worn by women, such as a shirt, blouse, or top, with short sleeves or no sleeves, that often fastens in the rear.
- A coarse or flimsy coffin; a thin interior coffin enclosed within a more substantial one.
- (Can we find and add a quotation of Knight to this entry?)
- (music) A string instrument, as a lyre, whose acoustical chamber is formed like a shell.
- The first lyre may have been made by drawing strings over the underside of a tortoise shell.
- 1687, John Dryden, A Song for Cecilia's Day
- when Jubal struck the chorded shell
- (music) The body of a drum; the often wooden, often cylindrical acoustic chamber, with or without rims added for tuning and for attaching the drum head.
- An engraved copper roller used in print works.
- The thin coating of copper on an electrotype.
- (nautical) The watertight outer covering of the hull of a vessel, often made with planking or metal plating.
- (nautical, rigging) The outer frame or case of a block within which the sheaves revolve.
- (nautical) A light boat whose frame is covered with thin wood, impermeable fabric, or water-proofed paper; a racing shell or dragon boat.
- (chemistry) A set of atomic orbitals that have the same principal quantum number.
- (figurative) The outward form independent of what is inside.
- (figurative) The empty outward form of someone or something.
- The setback left him a mere shell; he was never the same again.
- An emaciated person.
- He's lost so much weight from illness; he's a shell of his former self.
- A psychological barrier to social interaction.
- Even after months of therapy he's still in his shell.
- (computing) An operating system software user interface, whose primary purpose is to launch other programs and control their interactions; the user's command interpreter. Shell is a way to separate the internal complexity of the implementation of the command from the user. The internals can change while the user experience/interface remains the same.
- The name "Bash" is an acronym which stands for "Bourne-again shell", itself a pun on the name of the "Bourne shell", an earlier Unix shell designed by Stephen Bourne, and the Christian concept of being "born again".
- (business) A legal entity that has no operations.
- A shell corporation was formed to acquire the old factory.
- A concave rough cast-iron tool in which a convex lens is ground to shape.
- (engineering) A gouge bit or shell bit.
- (phonology) The onset and coda of a syllable.
- (Britain, slang) A person's ear.
- Synonym: shell-like
- Can I have a quick word in your shell?
Derived termsEdit
hard calcareous or chitinous external covering of many invertebrates
hard covering of an egg
entomology: exoskeleton of certain insects
covering of a nut
husks of cacao seeds
conjoined scutes that comprise the "shell" of a tortoise or turtle
overlapping hard plates comprising the armor covering armadillo's body
casing of an artillery projectile
hollow usually spherical or cylindrical projectile fired from a mortar or a cannon
cartridge of a breechloading firearm
any hollow structure; framework, or exterior structure
garment with short or no sleeves that often fastens in the rear
coarse or flimsy coffin
music: string instrument, whose acoustical chamber is formed like a shell
music: body of a drum
engraved copper roller used in print works
nautical: outer covering of the hull
nautical, rigging: outer frame or case of a block within which the sheaves revolve
nautical: light boat the frame of which is covered with thin material
computing: general-purpose environment
chemistry: set of atomic orbitals that have the same principal quantum number
emaciated person
business: legal entity that has no operations
- The translations below need to be checked and inserted above into the appropriate translation tables, removing any numbers. Numbers do not necessarily match those in definitions. See instructions at Wiktionary:Entry layout § Translations.
Translations to be checked: "hard outside covering, as of a fruit or an animal"
- The translations below need to be checked and inserted above into the appropriate translation tables, removing any numbers. Numbers do not necessarily match those in definitions. See instructions at Wiktionary:Entry layout § Translations.
Translations to be checked
shell (third-person singular simple present shells, present participle shelling, simple past and past participle shelled)
- To remove the outer covering or shell of something.
- To bombard, to fire projectiles at, especially with artillery.
- (informal) To disburse or give up money, to pay. (Often used with out).
- (intransitive) To fall off, as a shell, crust, etc.
- (intransitive) To cast the shell, or exterior covering; to fall out of the pod or husk.
- Nuts shell in falling.
- Wheat or rye shells in reaping.
- (computing, intransitive) To switch to a shell or command line.
- 1993, Robin Nixon, The PC Companion (page 115)
- Automenu is a good program to try, and offers a fair amount of protection - but, unfortunately, it's one of those systems that allow users to shell to DOS.
- 1993, Robin Nixon, The PC Companion (page 115)
- To form shallow, irregular cracks (in a coating).
- (topology) To form a shelling.
Derived termsEdit
to remove the outer covering or shell of something
to bombard, to fire projectiles at
informal: to disburse or give up money, to pay
Further readingEdit
- shell in Webster's Revised Unabridged Dictionary, G. & C. Merriam, 1913.
- shell in The Century Dictionary, The Century Co., New York, 1911.
- shell on Wikimedia Commons.Wikimedia Commons


text:
Jan 17, 2013– Orlando, USA (Techreleased) – Lockheed Martin has received a $90.6 million Performance Based Logistics (PBL) contract from the U.S. Army for sustainment of the Modernized Target Acquisition Designation Sight/Pilot Night Vision Sensor (M-TADS/PNVS) system.
The firm, fixed price contract provides a comprehensive sustainment solution that enables mission readiness, reduces operation and support costs, and drives reliability and maintainability improvements. This is the first of three options under the $111 million PBL contract awarded in 2012. The total four-year contract value is $375 million.
M-TADS/PNVS is the advanced electro-optical fire control system that Apache helicopter pilots use for safe flight in day, night or bad weather missions. It provides Apache pilots with long-range, electro-optical precision engagement and flying capabilities.
"Lockheed Martin works closely with the U.S. Army to provide highly reliable products to the warfighter while implementing efficiencies and cost-saving measures," said Tom Eldredge, program director of M-TADS/PNVS international and support programs at Lockheed Martin Missiles and Fire Control. "The U.S. Government and industry teams are focused on the continuous improvement of processes, services and products that benefit our warfighters."
PBL is a strategy for system product support that employs an integrated, affordable performance package designed to optimize system readiness. PBL offers supply availability that maximizes mission effectiveness and allows Apache aircrews to depend on the situational awareness and targeting accuracy provided by M-TADS/PNVS.
Lockheed Martin Missiles and Fire Control is a 2012 recipient of the U.S. Department of Commerce's Malcolm Baldrige National Quality Award for performance excellence. The Malcolm Baldrige Award represents one of the highest honors that can be awarded to American companies for achievement in leadership, strategic planning, customer relations, measurement, analysis, workforce excellence, operations and business results.


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text:
Murphy is trained to join the Portland Police Bureau's mounted patrol
View the Slideshow >>
(Gallery by Thomas Boyd, The Oregonian)
In the weeks before he was born, everyone had such high hopes. But as happens in life, nothing turned out as expected. As far as they knew, this horse would always match the name they chose for him.
His father was a big powerful Gypsy, a mysterious European breed not introduced to North America until the 1990s. The stallion, with a beautiful multi-colored coat, was bred with a hard-working Belgian mare.
Even though the colt was three weeks overdue, he was undersized. His coat was black. Although he had white on his nose and on the bottom section of one leg, no one visiting the Roseburg ranch would describe him as a beauty.
So they called him "Murphy's Law," a play on the idea that if something can go wrong it will.
In time, they shortened the name to Murphy, but the meaning behind the name stuck with the horse. He was easily distracted. When visitors arrived, he'd peel away from the other horses and trot over, plopping his nostril on someone's head. He had a younger half-brother -- same father, different mother -- who turned out to be everything Murphy would never be. Seamus was strong and regal, a three-time Oregon State Gypsy Supreme Champion and twice the regional champion.
"Being honest," owner Randy Snow said, "we ended up with five horses on the ranch and old Murphy was always low man on the totem pole."
Then fortunes changed.
Snow had never owned horses
, but he decided one day he wanted one as he surveyed the 230-acre spread he and his wife bought for retirement near Roseburg. He was a general contractor building their dream home on the land while his wife returned to Sonoma County in California to wrap up her real estate business.
Follow Murphy's progress
Follow Murphy as he goes through his paces and tries to make it as a Portland police horse.
Trainer Jennifer Mack expects to know by the end of February if Murphy has all the right stuff.
"I'd ridden one a couple times," he said, "but with all that acreage it seemed like a horse would be perfect."
He bought Lucy, a big workhorse, but wasn't sure how to break the news to his wife, so he waited until she returned to Oregon for a visit on her birthday.
"I figured if the horse was a gift," he said, "she couldn't say no."
His wife was stunned. "My God, he got me a horse," Jean Snow said. "I tried to be gracious, but I was scared. I'd ridden a horse a couple times, but 35 years ago. But I got used to Lucy."
Soon they bought a second horse, then found that their earlier purchase of Lucy came with a prepaid contract to breed with a full-blooded Gypsy from California. Lucy gave birth to Murphy. Six months later, Pretzel, the Snows' second horse, gave birth to Seamus.
Then things fell apart. The California real estate market collapsed, killing both the contracting and real estate businesses. The Snows sold their California home at a loss and moved into a manufactured home on their Oregon ranch.
Last October, the bank foreclosed on the property. The couple started selling anything they could. Seamus, Pretzel and another horse they'd bought went to a trainer.
Unable to afford hay, the Snows let Lucy and Murphy roam the acreage and eat grass, a diet akin to a human eating nothing but pizza. Since they weren't being ridden, the two horses packed on the pounds.
"We were getting to the point where we had no money," Randy Snow said. "We had to get rid of another horse. We settled on keeping Lucy. She was our first one. She was the birthday gift.
"What we were left with was Murphy," he said. "In the horse world, he was nothing special."
Late last year, they posted a Craigslist ad: Horse for sale, $3,000.
It all made sense. From the day he was born, Murphy was never the star. No one had time to ride him.
And out there on the open land that the Snows had lost, he was a reminder of how in life nothing turns out as expected.
All true.
Also true is that life occasionally offers a second chance.
Hundreds of miles away
, Jennifer Mack sat in front of her office computer. For months she had been searching the Internet looking for a horse. In late September,
, fell victim to the Great Depression and was resurrected in 1979. In all those years, only three horses had ever died on duty. As the unit's equestrian and training instructor, Mack had to find a horse to replace the beautiful and majestic Ian, considered the best horse to have ever served in the nine-horse unit.
Mack had been making calls across the Pacific Northwest.
"The horse has to be a gelding, a neutered male," she said. "They can't be too big or too small. If they're too tall, it's difficult for an officer to lean down and search a suspect. If they're too small, they can't pack the officer and all the equipment."
Mack had looked at more than 20 horses on the Internet, made calls to owners and gone to check some out in person. She brought in two horses for a tryout, but neither made the cut.
One day in late November, she clicked on a Craigslist ad for a horse. She studied the photograph, read the description and called the owners who lived in Roseburg.
"The horse looked a little small, but at least he was stout," she said. "The owner told me the horse was green, inexperienced, but had a great personality. I thought it was worth a drive to Roseburg to look for myself. I brought along the unit sergeant and an officer."
Photo essay
Once at the property
, Mack talked with Jean Snow while her husband went off to get Murphy.
"The first time I saw him," she said, "Randy was leading him up through the pasture. He was taller than I thought, but not too tall."
Then Murphy stood in front of Mack.
"He was overweight," she said. "Some horses look fat, but underneath it's muscle. With Murphy it was just blubber."
Being out of shape was enough for Mack to take a pass. But she'd made the long drive, so she decided to give him a series of tests that all candidates must pass, almost like the NFL Combine for college football prospects.
Mack had the officer lead Murphy in a circle while she watched his gait, paying particular attention to the joints.
Then it was time for the tests, trying to duplicate the stimuli a police horse faces. If Murphy failed even one test -- kicked, panicked or tried to run away -- he was out.
She started by blowing a horn that sounded like a flock of geese, tested him by rubbing him unexpectedly with a grocery bag, then shook a can full of rocks. She loaded a burlap bag with empty cans, tied one end with a rope and dragged it around Murphy, even throwing it near his back end. Then she brought out the black plastic.
"It's tactile and makes noise when a horse steps on it," Mack said. "All those things can be frightening. We've had some horses that have to be dragged to the plastic. Others step on it and leap over it. Murphy just stood there and took a chunk out and tried to eat it."
In all her years on the unit, Mack had never seen a potential candidate do so well.
"For the final test I toss a bucket at the rear end," she said. "Not to scare them, but surprise them. If they kick at the can, or bring up a leg, they fail."
She tossed the can.
"He noticed it," she said, "but he didn't care."
She did it again.
"No response," she said. "He didn't even move."
Mack picked up the can and studied this horse.
"I wondered if he didn't want to move because he was so calm," she said. "Or was it because he was too fat to move."
She climbed on Murphy
and rode him to see if anything felt quirky. Mack could tell there were some things she'd need to correct. But she still wasn't set.
Murphy's weight was an issue.
Days later, Mack searched the Internet again and made a few calls about other horses. She kept coming back to Murphy, and gathered the officers around a table.
"The more we talked," she said, "the more we realized there was something about him." They came to a decision: Let's give him shot.
Murphy arrived at the mounted patrol barn in Northwest Portland on Dec. 11. He had 30 days to make the first cut.
Mack learned Murphy weighed 1,900 pounds, about 200 pounds too many. The unit didn't have a saddle big enough to fit around him. Like a human facing a New Year's resolution, Murphy's routine quickly changed from life on the range to horse aerobics.
The barn features an electric walker, a kind of a treadmill that gently prods a horse to keep walking in a circle. Murphy had three one-hour sessions a day.
"A person who's been sitting on the couch for years isn't going to get up and start jogging five miles a day," Mack said. "I had to get him conditioned before we could see what he had."
The first week, he could trot in a circle for five minutes and canter for two. By late January, he was trotting for 35 minutes and cantering for 10.
He made the first cut.
"The other horses have accepted him," Mack said. "He's like a kid that needs attention. If he feels like he's not getting enough, he likes to kick his barn door. He has huge feet. The older horses look at him like he's the pest in the class. They play with him for 20 minutes, then pass him on to another horse."
Mack believes Murphy could be the best horse ever.
But he still has much to prove in the next 30 days. He must show he can handle the intensive training required for a police horse.
"I warned all the officers not to get too attached to Murphy. It's too late," Mack said. "Everyone is rooting for him."


text:
Margaret Harloe
I have been interested in both biology and teaching for as long as I can remember. As an undergraduate, I initially focused on animal behavior but switched my attention to plants after taking a sophomore level botany course. I eventually earned a BS in plant pathology from the University of California, Davis, and a MS in molecular biology from New Mexico State University. My research explored the expression of genes coding for small antimicrobial proteins in a plant model.
One of my primary goals has always been to share my love of biology through teaching and I am especially interested in helping students navigate the first years of college. I have taught at a number of other colleges, and moved to SLU in the fall of 2004, to help with lab instruction for General Biology. I enjoy the engagement and interaction of lab instruction, and the opportunity to get to know my students. I find the variety of topics covered in General Biology stimulating and love the opportunity to continually learn new and details about the living world.


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The secret of fertile sperm
To better understand the causes of male infertility, a team of Bay Area researchers is exploring the factors, both physiological and biochemical, that differentiate fertile sperm from infertile sperm. At the 58th Annual Biophysical Society Meeting, which takes place Feb. 15-19, 2014, in San Francisco, Calif., the team will present its work to identify and characterize proteins known as ion channels, which are crucial for sperm fertility and expressed within a sperm cell's plasma membrane.
"Any knowledge gained in this area may help create much-needed diagnostic testing and treatments for male infertility, which is in essence an idiopathic disease, because at this time 80 percent of male infertility cases can't be diagnosed or treated," said Melissa Miller, a postdoctoral fellow who will present the team's findings at the meeting. Miller works in the labs of both of her co-authors, Polina Lishko of the University of California, Berkeley (UCB), and Yuriy Kirichok at the University of California, San Francisco (UCSF).
To study ion channels, the researchers are recording the electrical activity of sperm ion channels under strictly controlled conditions.
"Our labs have characterized three ion channels responsible for regulating calcium (CatSper), potassium (Slo1), and protons (Hv1) within sperm cells," Miller said. "So far, the most well-studied is the sperm cation channel CatSper, which is exclusively expressed within sperm cells and represents an ideal target for development of a unisex contraceptive; no other cell in the body is known to express this protein."
"We recently reported that the female hormone progesterone activates CatSper via a non-genomic pathway. In normal fertile spermatozoa, CatSper activity was greatly increased by the addition of progesterone. However, patch clamp recording from patient-derived sperm cells with CatSper deletion showed no response to progesterone nor did they produced basal CatSper current," Miller said. "This shows direct regulation of the CatSper channel in human sperm by steroid hormones."
Steroid hormones control the fundamental physiological functions via both traditional genomic and unconventional, nongenomic pathways. Previous research established that nongenomic signaling plays a vital role in both human sperm cell activation and pain perception modulation within neurons of the spinal cord. Because the molecular determinants of this pathway are poorly understood, Miller's team is working to uncover the precise molecular signaling cascade that occurs in sperm cells and neurons upon progesterone treatment.
"The lack of CatSper activity is strongly correlated with male infertility, so identification of this endogenous signaling molecule would give us a novel biomarker for male fertility that could be immediately used in the clinic as a way to quickly assess sperm fertilization potential," Miller said.
Overall, the knowledge gained from the team's studies may be used in the future development of new pain management therapies, as well as diagnostic tests and treatments for male infertility.
The presentation "Regulation of CatSper Channel through Non-conventional Lipid Signaling" by Melissa R. Miller, Yuriy Kirichok and Polina Lishko will be at 10:00 a.m. on Tuesday, February 18, 2014 in Room 306 in San Francisco's Moscone Convention Center.
Each year, the Biophysical Society Annual Meeting brings together more than 7,000 researchers working in the multidisciplinary fields representing biophysics. With more than 4,200 poster presentations, over 200 exhibits, and more than 20 symposia, the BPS Annual Meeting is the largest meeting of biophysicists in the world. Despite its size, the meeting retains its small-meeting flavor through its subgroup symposia, platform sessions, social activities, and committee programs.
The 58th Annual Meeting will be held at the Moscone Convention Center, 747 Howard Street, San Francisco, California.
The Biophysical Society, founded in 1958, is a professional, scientific Society established to encourage development and dissemination of knowledge in biophysics. The Society promotes growth in this expanding field through its annual meeting, monthly journal, and committee and outreach activities. Its 9000 members are located throughout the U.S. and the world, where they teach and conduct research in colleges, universities, laboratories, government agencies, and industry.
Jason Socrates Bardi
American Institute of Physics