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Earlier today, Irrational Games released a post on their site governing answers to the many questions they have recieved from fans about the PC version of Bioshock Infinite coming out in March.
Bioshock Infities a pretty cool guy...he answers questions and doesnt afraid of anything
Wow that was a terrible interview, there was nothing answered that we didn't know already just by looking at the minimum/recommended specs
Should be a decent port, i will get it on pc instead of consoles, eventually.
the guy making the interview appears to have little or no knowledge at all about PC gaming lol
read this:
Q: How would it run on a GTX460?
Chris Kline: I have not personally tested with this specific graphics card, and I don't have access to your machine, so I'm not able to give you hard numbers. However, that card is above our minimum requirements for graphics cards. Therefore if your machine meets the other minimum requirements for BioShock Infinite, I believe it will run well.

subset: commoncrawl


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This Pharaohs of Ancient Egypt iPhone 7 snap cases are super slim and add minimal bulk to your phone. When the case are applied to your phone, all buttons, all ports and head phone jacks are fully accessible and sit straight onto speakers and charging cables. Originally designed by our Team and using an unique heat transfer process. Fits and designed for iPhone 7.
- Ultra slim, lightweight, protective case.
- Heat resisting, high flexibility, no deformation
- Clear image printed
- Finished with protective glossy coating for image clarity and durability
- Carefully packed.


text:
< Features
oVirt engine 3.1
The oVirt engine is the management application of the oVirt virtualization platform. Version 3.1 is the latest version, including the GUI and many important new features.
- Name: Juan Hernández
- Email: email@example.com
Current status
- Targeted release: Fedora 18
- Last updated: 2012-7-18
- Percentage of completion: 70%
Detailed Description
Version 3.0 of the oVirt engine was already included in Fedora 17, but we want to bring the new features provided by version 3.1 and we want also to include the GUI applications (web admin and user portal) that were not included because they require GWT.
Benefit to Fedora
Adding version 3.1 of the oVirt engine and the GUI applications to Fedora will attract users that are currently using the upstream project and will provide a complete and seamless virtualization management solution, with a web interface that can be used from virtually any place.
The scope of the feature includes the update to upstream version 3.1 and the addition of the GUI applications that were not included in Fedora 17.
How To Test
In order to test the user will need to install the ovirt-engine package in any Fedora supported platform (the packages are
yum install ovirt-engine
Once the feature is 100% completed this will download and install all the required packages, including the GUI applications.
After the installation the user will need to run the
engine-setup command line tool. This tool will ask for the details of the environment (ports, passwords, host names, etc), will take care to do all the required configuration changes and will start the required services.
Once the setup is completed and the services up and running the user will use the GUI applications to add hypervisors (using oVirt node or Fedora itself), configure storage and manage virtual machines.
See the testing section of the oVirt wiki for detailed instructions.
User Experience
Users will have the ability to setup a complete virtualization management environment using GUI tools.
The major dependency of this feature is GWT 2.4.0 (Google Web Toolkit [1]), the rest of the dependencies of oVirt engine where added to fedora as part of the effort to include version 3.0 of the oVirt engine.
We intend to work closely with the owners of other features that also require GWT.


text: The B3 Passat was heavily facelifted in 1993 and although it was designated B4, it was not an all-new model. The facelift revised external body panels except for the roof and glasshouse, with most obvious exterior change seeing the re-introduction of a grille to match the style of the other same-generation Volkswagen models of the era, such as the Mk3 Golf and Jetta. A much misunderstood fine car.


text:
Dior B23 Oblique High Top Sneakers
The latest all white colourway in the Dior B23 Oblique High Top Sneakers by Kim Jones.
Some items include a sourcing fee. This is a fee added to the retail price. Fee's vary depending on the time / resources used to source the item. Sourcing fees are included in the price you see on your screen.
Please allow 3-5 working days (excluding weekends) for sourcing and delivery of UK & EU orders and 4-6 working days for International orders. See our delivery page for further information and express delivery options.


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Squamish Valley Music Festival
Feat. Bruno Mars, Arcade Fire, Eminem, Sam Roberts Band, The Roots, Tune-Yards and more
Aug. 8-10 | Centennial Field, Logger Sports Grounds and Hendrickson Fields (Squamish)
Tickets and info: squamishfestival.com
2014 has been a year of big gambles and transformations for B.C.'s music festival scene: Pemberton making a return on the music front; Boonstock pushing for a party in Penticton (with more than a few hurdles); Rock The Shores and Rifflandia shaking up Vancouver Island island a little more every year; and veterans like the Vancouver Folk Music Festival feeling the pull of upstarts scratching away at their younger audiences and pecking away at the roster of new folk and electronic acts.
And then there is the Squamish Valley Music Festival.
For five years, the festival's bubble has been growing bigger. From 7,500 daily fans in 2010, the festival reached capacity in 2013 with a daily attendance of 17,000.
This year, the festival is doubling in size, with a potential 35,000 people attending the event each day this weekend (Aug. 8-10), with top acts like Eminem and Arcade Fire towering over previous headlining acts brought in by the festival (Bad Religion in 2010; Weezer in 2011; The Tragically Hip in 2012; and Queens of the Stone Age in 2013).
This year's crop of top acts is similar to what you would find at a Sasquatch, Lollapalooza or Coachella.
But Squamish's grand transformation did not happen overnight. It was planned well in advance, especially on the logistical side of things.
"There's been a lot of legwork that has been put in on the development of campground and parking areas — the support land you need to execute something of that size," said Paul Runnals, SVMF executive producer and senior VP for promoter brand. LIVE. "That's been going on for two and a half years. We became property developers along the way and create and modify spaces to get what we needed done.
"The evolution that Paul talks about is the essence of what great festivals have gone through," chirped in Erik Hoffman, senior VP of talent for Live Nation, brand.LIVE's partner in the Squamish venture.
The festival can now accommodate 16,000 camping fans, and the festival's site itself has been expanded to include Squamish's Centennial Field, essentially doubling the festival grounds.
It's all happening in a year where direct competition created a perfect storm of speculation, especially to outside observers.
With the Pemberton Music Festival coming back into the fold in Spud Valley under a different umbrella than Live Nation's and attracting approximately 20,000 daily fans three weeks before Squamish, many observers wondered if the two festivals could peacefully coexist.
"It's no secret (Pemberton) was trying to resurrect the festival since 2009," Runnals said, referring to the year Live Nation set up the original Pemberton Music Festival featuring rapper Jay-Z and British rock band Coldplay. "It wasn't a secret that it was coming. There was talk even before last year's (Squamish) festival that they might try to get something off the ground for 2013. That kind of stuff you can't keep under wraps for a very long time. By the same token, we've been trying to get our event to this size for two years as well. So they're parallel paths.
"It's important to note it's not just that property but that others in the region have popped up as well," Hoffman added. "It's one thing to talk about Pemberton, but frankly there are others on the Island and in the Interior that aren't terribly different in size. It's all part a growing festival landscape in British Columbia."
According to Runnals and Hoffman, early numbers are promising. The SVMF expects 32-33,000 fans to come see rapper Eminem give his only Canadian concert this year on Sunday. The other two days are looking at an estimated 27-28,000 fans per day.
"We'll be at capacity," Hoffman said.
Music fans can look forward to the festival continuing to host a number of Vancouver and B.C. bands, a trademark of the festival since its inception. This year will feature local talent like dance music rising star Felix Cartal, electro-pop singer-songwriter Louise Burns, roots-rockers The Matinee, and Juno-winning rapper Shad for an undercard built on eclectic tastes.
Second-tier acts will include rapper Nas (performing his classic album Illmatic) and hip-hop legends The Roots, Canadian favourites Serena Ryder and Sam Roberts Band, electronic innovator John Digweed, and British rockers Arctic Monkeys.
The festival has been working hard at upping its security and safety planning, hiring a security staff of 600 and working with a new director of public safety. Safety engineers have been hard at work for eight months preparing the SVMF for the weekend, drafting emergency planning protocols.
Traffic processing has been revamped, with campers being offered shuttle service from large parking areas at Brittania Beach and from Squamish's Industrial Park, freeing up the Sea to Sky corridor as much as possible.
"There's a ton of work that's been going on behind the scenes," Runnals said. "We're confident we have the right people to pull it off. We're building a community here, and a fairly large-sized one."


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NBC Banks on Staying Power of 'The Voice'
Singing competitions live and die by their judges, and none more than the hugely popular "The Voice." And as the talent-show juggernaut enters its fifth competition, the show's importance to NBC is greater than ever. Merissa Marr explains on Lunch Break.
This transcript has been automatically generated and may not be 100% accurate.
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LOS ANGELES (October 17, 2012) — The Shadow Gang, a new breed of entertainment studio based in Los Angeles, today unveiled its proprietary multi-platform distribution engine, titled 'Galahad™' at the StoryWorld Conference + Expo. Galahad provides a scalable and efficient way to create, socialize and monetize content.
Galahad is the first and only turnkey platform that allows users to preload and run entire story-worlds and campaigns from a single, centralized hub, including online and mobile content, gaming, social media and e-commerce extensions. With the rise in demand from content creators, distributors and brands for robust digital experiences to connect with audiences and expand revenue potential, The Shadow Gang developed Galahad as a solution to 'power up' content to generate engagement and profit for media executives, distributors, producers, marketing managers, writers and community managers. Relevant for the film, television, publishing, gaming and marketing industries, Galahad arms users with the tools to:
- Create compelling, interactive branching videos, logic games, interactive comics, point/reward systems and trackers and much more to drive deeper, longer fan engagement.
- Monitor and enhance audience engagement with extensive and accurate analytic data.
- Sell, manage and administer virtual and real world story-related merchandise.
- Drive fans to new and relevant content, interactions and rewards.
- Generate new distribution channels for revenue growth.
Galahad simplifies the management and distribution of original media through proprietary, custom-built tools designed to connect with and engage fans with story-worlds across platforms. Additional services can be added to Galahad's core tools to deepen fan integration and message reach including capabilities in augmented reality, SMS and second screen mobile. Content creators and brands can upload their existing content or have The Shadow Gang produce original content that can be used to expand and prepare their property for multiple platforms.
As part of the Galahad toolset, and available now as a stand-alone tool, the Immersive Video Builder* is a unique, highly flexible video player that lets the content creator sequence their content in such a way that allows the viewer to affect the story as they watch it in a 'choose your path' interactive video experience. The player, built in HTML5 for mobile and web access, allows users to add choices and logic into their content, resulting in increased viewer engagement. A "Click 'K' for Killer" interactive video demonstration of the tool, shot and produced entirely by The Shadow Gang, can be played here.
"As a producer and director for many years, I know how content creators are struggling to keep up with the digital demands of audiences," said Alex LeMay, co-founder and CEO of The Shadow Gang. "That's why we created Galahad as an efficient and manageable platform to help others produce multi-platform digital experiences that release content, messages and rewards at strategic moments for their TV episodes, movie launches or major book releases."
On Thursday, October 18, The Shadow Gang will present Galahad in an interactive demonstration at StoryWorld starting at Noon in the main exhibit hall.
"There are so many never-before-seen opportunities for revenue growth in content production today," said Josh Lamb, co-founder and chief operating officer of The Shadow Gang. "Galahad can help creators and distributors realize these opportunities and capitalize on them."
The Galahad concept of a ready-made distribution engine for content creators and distributors was born out of the successful digital multiplatform campaign 'GoBZRK,' created by The Shadow Gang in 2011 to cultivate audiences and drive pre-sale buzz for the global book launch of BZRK, written by best-selling author Michael Grant. The Shadow Gang created the idea and original content from the ground-up and took audiences through an immersive and compelling storyline that unfolded across multiple touch points including websites, comic books, social media, an iOS and Android 3D game and interactive experiences. GoBZRK built massive audience participation and marketplace momentum with impressive results including driving foreign publishing sales in 14 countries in less than three months, garnering 100,000 unique visitors, 245,000 video views across all BZRK sites and 432,000 page views, without the use of ad buys.
The name Galahad hails from Arthurian legend representing one of the most celebrated knights from King Arthur's court. The legend of King Arthur and the Knights of the Roundtable has been told across books, movies, games, toys, comics and every single medium imaginable and Galahad, as a distribution engine, pays tribute to one of the greatest and most withstanding narratives of all time.
For more information about The Shadow Gang and Galahad, visit www.theshadowgang.com and follow the company on Facebook and Twitter.
About The Shadow Gang
The Shadow Gang is a new breed of entertainment studio that creates original media experiences using 'Galahad,' the studio's proprietary, turnkey multi-platform distribution engine. With Galahad, The Shadow Gang helps content owners and distributors to expand distribution channels, build and engage new audiences, and realize new revenue potential. The Shadow Gang not only builds interactive, multi-platform experiences for partners in film, television, publishing, gaming, major branding and more, the studio also develops and produces original content across genres, platforms, and devices. The Shadow Gang has offices in Los Angeles, New York and Chicago. For more information, visit www.theshadowgang.com and follow the company on Facebook and Twitter.


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St. Thomas of Villanova Church in Goshen rings in spring with annual flea market
Goshen >> The St. Thomas Chapel Committee rang in spring early. The 12th annual flea market opened three weeks before the vernal equinox, on Saturday. The committee brought together dozens of tables of tag sale goods from donors and vendors alike.
"We were busy from the beginning," said flea market co-chair Cathy Nygren, about the event's inception. "We've always sold out on our tables."
People are so excited to come in the door by 8:30 a.m. Saturday, Nygren said, "They sneak in and we have to kick them out. When we opened the door, there had to be 50 people in the vestibule and they were pushing like maniacs."
Nygren said each year the sale raises about $1,500, which contributes to the upkeep of the chapel at St. Thomas of Villanova Church. About 15 volunteers put the event on each year, and in addition to organizing the event, also sell homemade chili and hotdogs.
Patrons range from "antique-y people" to "tag salers." Some rush through the sale, others take their time browsing. Both come for "the first big tag sale of the season," said Nygren. Even though the sale ended at 2:30 p.m., there were still dozens of browsers late into the afternoon.
The sale annually offers everything from broaches and clothing to cameras and homemade pepper jelly. Even a wedding dress was on sale Saturday, priced at $400 "or best offer," although most items don't come close to being that expensive. Pepper jelly made in Goshen, for example, was priced at $5. As one seller said, many tables were, "negotiable."


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Can distance be increased to say around 75m - 100m?
What is the data rate / sec you need? Tell us about your application, there are always other solutions
Its for hoe automation device.
It's almost spring. Lots of weeding to be done. I'm interested in this automated hoe of yours. Can I sit and drink beer and watch it do the weeding?
I used P82B715PN I2C extender IC from Philips. Very cheap and easy:http://pdf1.alldatasheet.com/datasheet-pdf/view/15876/PHILIPS/P82B715PN.html
How much distance can I can expect by using this IC?
http://www.nxp.com/acrobat_download2/literature/9398/39340011.pdfhttp://ics.nxp.com/products/i2chubs/Long Distance I2C or SMBusThe P82B715, P82B96, and PCA9600 are specifically designed to extend the reach of the I2C or SMBus over long distances, in the range of kilometers, depending on the maximum bus speed. This allows the designer to use I2C to interconnect equipment cabinets or for large area systems such as warehouse pick and place systems.


text: While Julio Lugo is resting his sore ankle, he is earning a little spare change minding our site, as we enjoy the beautiful weather outside. Unfortunately he is not very savvy and our RSS feed is now as sore as his ankle. We promise that he is working on the problem and should have it fixed shortly…as soon as he figures out that the DVD tray is not a cup holder.


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Folic Acid and Zinc Supplementation Trial (FAZST) (FAZST)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01857310
Recruitment Status : Completed
First Posted : May 20, 2013
Last Update Posted : August 22, 2019
- Study Details
- Tabular View
- Results Submitted
- Disclaimer
- How to Read a Study Record
The overarching goal of this trial is to determine if an intervention comprising folic acid and zinc dietary supplementation improves semen quality and indirectly fertility outcomes (i.e., live birth rate) among couples trying to conceive and seeking assisted reproduction. The following study objectives underlie successful attainment of the overarching research goal:
- To estimate the effect of folic acid and zinc dietary supplementation on semen quality parameters, including but not limited to concentration, motility, morphology, and sperm DNA integrity, relative to the placebo group.
- To estimate the effect of folic acid and zinc dietary supplementation on fertility treatment outcomes [fertilization, embryo quality, implantation/human Chorionic Gonadotropin (hCG) confirmed pregnancy, clinical pregnancy, live birth], relative to the placebo group.
- To estimate the association between semen quality parameters, sperm DNA integrity and fertility treatment outcomes (fertilization, embryo quality, clinical pregnancy, live birth) and to identify the best combination of semen quality parameters for prediction of clinical pregnancy and live birth.
- To estimate the effect of folic acid and zinc dietary supplementation on fertilization rates among couples undergoing assisted reproductive technology procedures, relative to the placebo group.
- To estimate the effect of folic acid and zinc dietary supplementation on embryonic quality among couples undergoing assisted reproductive technology procedures, relative to the placebo group.
|Condition or disease
|Pregnancy Live Birth Spontaneous Abortion
|Dietary Supplement: 5 mg folic acid and 30 mg elemental zinc Drug: Placebo Comparator: Placebo
|Not Applicable
Two micronutrients fundamental to the process of spermatogenesis, folic acid (folate) and zinc, are of particular interest for fertility as they are of low cost and wide availability. Though the evidence has been inconsistent, small randomized trials and observational studies show that folate and zinc have biologically plausible effects on spermatogenesis and improved semen parameters. These results support the potential benefits of folate on spermatogenesis and suggest that dietary supplementation with folate and zinc may help maintain and improve semen quality, and perhaps, fertility rates.
The Epidemiology Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development intends to conduct a multi-site double-blind, randomized controlled clinical trial to evaluate the effect of folic acid and zinc dietary supplementation on semen quality and conception rates among male partners of couples seeking assisted reproduction. Randomization will be stratified (with random sequences of block sizes) by site and assisted reproduction technique (IVF, non-IVF receiving fertility treatment at a study site, and non-IVF receiving fertility treatment at a nonstudy site) to ensure that balance between the treatment groups is maintained within site and within fertility treatment type over the enrollment period.
The study is designed with a sample size of 2,400 randomized participants based on obtaining adequate power to detect meaningful differences in the live birth rate between cohorts. Since the comparison of sperm parameters are differences between continuous assay measurements, this sample size will be more than sufficient for the primary sperm parameter comparisons. Additionally, calculations were done to demonstrate adequate statistical power when stratified analysis is to be performed (i.e., sample size distributions among the strata and their corresponding live birth RRs detected at 80% statistical power, with an alpha level of 0.05 and a total sample size of 2400 couples divided among the folic acid/zinc and placebo arms of the trial).
Data collection will include screening male and female partners for eligibility, administering baseline questionnaires, and collecting biospecimens in both partners of the couple, body measurements for both partners, daily journal reporting for male partners, medical record abstraction related to required treatment and outcome data, and semen quality of four samples collected at baseline, two, four, and six months following study enrollment. A data coordinating center (DCC) will support the trial.
The primary analysis plan is based on an "intention-to-treat" (ITT) approach comparing the two cohorts based on the randomized assignment, both overall and by treatment strata (IVF, non-IVF receiving fertility treatment at a study site, and non-IVF receiving fertility treatment at a nonstudy site).This approach will be applied to the two primary endpoints (semen parameters and live birth rate) as well as designated secondary endpoints (number of follicles, number and proportion of oocytes fertilized).
The DCC will perform periodic safety analyses and present interim reports to the Data and Safety Monitoring Board (DSMB) as requested, during the recruitment phases of the trial. It is anticipated that safety analyses will be performed every 6-12 months. The final analysis will be performed upon completion of data collection and editing in the follow-up and close-out phase of the trial. Also one full formal interim analysis is planned and the power calculations with considerations for the choice of optimal time for the analysis have been conducted.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|2372 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|Folic Acid and Zinc Supplementation Trial: A Multi-center, Double-blind, Block-randomized, Placebo-controlled Trial
|Actual Study Start Date :
|June 2013
|Actual Primary Completion Date :
|June 2019
|Actual Study Completion Date :
|June 2019
Experimental: Folic acid and zinc supplementation
5 mg folic acid and 30 mg elemental zinc, taken orally, daily for 6 months.
Dietary Supplement: 5 mg folic acid and 30 mg elemental zinc
Placebo Comparator: Placebo
Matching placebo, taken orally daily for 6 months.
Drug: Placebo Comparator: Placebo
- Live birth [ Time Frame: At delivery ]Live birth assessment will be based on hospital delivery records.
- Change in semen quality [ Time Frame: Semen quality will be assessed at baseline, 2 months, 4 months, 6 months ]Semen quality will be assessed via standardized quantification of volume, concentration, motility, morphology, sperm count, and sperm DNA fragmentation index.
- Human chorionic gonadotropin (hCG) detected pregnancy (implantation) [ Time Frame: For IVF, 12 days post embryo transfer for day 5 embryo transfers, and 14 days post embryo transfer for day 3 embryo transfers; For couples undergoing OI/IUI, after self-report of positive pregnancy test ]A quantitative hCG evaluation in serum > 5 milli-international units per milliliter (mIU/ml)
- Clinical intrauterine pregnancy [ Time Frame: 6.5 weeks ]Visualized gestational sac in the uterus on ultrasound.
- Ectopic pregnancy [ Time Frame: 6.5 weeks ]Either visualization of no gestational sac in the uterus with a suspicious mass in the adnexa on ultrasound, an hCG level more than 1500 mIU/ml without visualization of an intrauterine gestational sac on ultrasound, or a slowly rising or plateauing serum hCG level without visualization of an intrauterine gestation on ultrasound.
- Early pregnancy loss [ Time Frame: Up to first 20 weeks of pregnancy ]hCG pregnancy loss will be defined as a serum hCG > 5 mIU/ml followed by a decline. Clinically recognized pregnancy losses will be defined as visualization of an intrauterine gestational sac followed by a loss prior to 20 weeks gestation.
- Other specific pregnancy outcomes [ Time Frame: Delivery ]Cesarean section, preeclampsia, gestational diabetes, growth restriction, gestational age, preterm birth, birth weight (small for gestational age), major neonatal complications (including death) and severe post-partum maternal morbidity. Outcomes will be determined based on hospital records and medical chart abstraction.
- Early embryonic development parameters: [ Time Frame: Couples will be followed for up to 9 months of fertility treatment ]Fertilization rates, method of fertilization, number of cells and embryo morphology on day 3 and day 5, number of good quality embryos on day 5, proportion of good quality embryos on day 5, number of embryos transferred, quality of embryos transferred, number of embryos cryopreserved, and sperm penetration assay results.When available, information regarding the chromosomal complement of embryo will be assessed.
- Reproductive hormones and other measured biomarkers [ Time Frame: Semen quality will be assessed at baseline, 2 months, 4 months, 6 months ]Measured urinary, serum, and salivary concentrations (collected at baseline and month 2, 4, and 6 clinic visits) of reproductive hormones, particularly androgens, proteomic analysis of human sperm and cardiometabolic risk factors and markers of oxidative stress, as well as measures of trace elements in toenails (collected at month 4 clinic visit).
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 45 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Couples Inclusion Criteria:
- Heterosexual couples in a committed relationship with a female partner aged 18-45 years and male partner aged 18 years and older attempting to conceive and seeking assisted reproduction at participating fertility clinics.
- Couples actively trying to conceive.
- Couples who are planning ovulation induction (OI), natural fertility optimization methods, or intrauterine insemination (IUI) should be willing to be on the study dietary supplement for at least 3 weeks before starting the next assisted reproduction cycle.Women with regular periods may initiate their fertility therapy at the start of the woman's menstrual cycle following randomization if randomization occurred within the first 10 days of the cycle, but must wait one menstrual cycle if the visit occurred after day 10 of the cycle). For women with irregular periods or amenorrhea, the male must be on the study supplement for 3 weeks prior to initiation of any ovulation induction medication (e.g., clomid, letrozole, gonadotropins).
Couples Exclusion Criteria:
- Female partner unwilling to participate (e.g., no abstraction of her assisted fertility treatment record or unwilling to complete baseline visit).
- Couples using donor, cryopreserved sperm, or sperm obtained via microsurgical or percutaneous epididymal sperm aspiration.
- Couples attempting to conceive with a gestational carrier (surrogate).
- Positive urine pregnancy test at screening.
Male Inclusion Criteria:
- Willing to provide semen samples according to the proposed schedule at baseline, 2, 4, and 6 months of follow-up.
- Able to complete regular study questionnaires and daily journals aimed at capturing ejaculation, sexual intercourse and lifestyle factors considered to affect male fecundity (e.g., cigarette smoking, fever, high temperature environment and other environmental exposures) and other data collection instruments (e.g., physical activity, food frequency questionnaire, stress).
Male Exclusion Criteria:
- Age <18 years.
- Unwilling to abstain from use of non-study approved dietary supplements or medications containing folic acid or oral preparations containing zinc throughout the study.
- Unwilling to abstain from use of testosterone supplementation throughout the study.
- Diagnosis of Vitamin B12 deficiency or pernicious anemia.
- Consuming a vegan diet.
- A known genetic cause of male factor subfertility, including chromosomal disorders related to subfertility (e.g., Y chromosome deletions).
Males currently using and unwilling (or unable) to discontinue the following drugs known to interact with folic acid or interfere with the biosynthesis of folic acid will be excluded.
- Dihydrofolate reductase inhibitors: Trimethoprim, Triamterene, Bactrim, Iclaprim
- Sulfonamides: Hydrochlorothiazide (HCTZ), Metolazone, Indapamide, Lasix, Bumex, Torsemide, Chlorthalidone, Acetazolamide, Mefruside, Xipamide
- Sulfonylureas: Glipizide, Glyburide
- Cox-2 inhibitors: Celecoxib
- Others: Valproic acid, Probenecid, Sulfasalazine, Sumatriptan, Mafenide, Ethoxzolamide, Sulfiram, Zonisamide, Dorzolamide (optic), Dichlorphenamide, Fluorouracil, Capecitabine, Methotrexate
- History of organ transplantation.
Physician diagnosed:
- Current poorly controlled chronic diseases such as heart disease, diabetes mellitus, hypertension, cancer, inflammatory diseases, autoimmune, thyroid disease, endocrine dysfunction, liver disease, kidney disease, or HIV/AIDS or other immune-insufficient related illnesses.
- Crohn's disease, celiac disease, ulcerative colitis, gastric bypass surgery, lap band surgery or history of intestinal surgery to remove a portion of small bowel. History of diseases/symptoms that require folic acid dietary supplementation, such as megaloblastic anemia, homocystinemia, and homocystinuria.
- History of alcohol dependency disorder and/or other drug/substance dependency in the past 180 days.
- History of psychoses or other mental conditions that would result in cognitive impairment and inability to participate in any part of this study including the informed consent process, as diagnosed by a physician within the past year.
- History of vasectomy without reversal, obstructive azoospermia such as Congenital Bilateral Aplasia of Vas Deferens (CBAVD), or ejaculatory duct obstruction.
- Known allergy to folic acid or zinc dietary supplements.
Female Exclusion Criteria:
Age <18 or >45 years.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01857310
|United States, Illinois
|Northwestern University
|Chicago, Illinois, United States, 60611
|United States, Iowa
|University of Iowa
|Iowa City, Iowa, United States, 52242
|United States, Minnesota
|Center for Reproductive Medicine
|Minneapolis, Minnesota, United States, 55407
|United States, Utah
|University of Utah
|Salt Lake City, Utah, United States, 84132
|Study Director:
|Enrique F. Schisterman, PhD
|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|Study Director:
|Sunni L. Mumford, PhD
|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|Principal Investigator:
|C. Matthew Peterson, MD
|University of Utah
|Principal Investigator:
|Jared C. Robins, MD
|Northwestern University
|Principal Investigator:
|Ginny L. Ryan, MD, MA
|University of Iowa
|Principal Investigator:
|Bradley J. Van Voorhis, MD
|University of Iowa
|Responsible Party:
|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
|First Posted:
|May 20, 2013 Key Record Dates
|Last Update Posted:
|August 22, 2019
|Last Verified:
|August 2019
Folic Acid
In vitro fertilization
Assisted reproductive technology
Ovulation induction
Intrauterine insemination
Live Birth
Abortion, spontaneous
Abortion, Spontaneous
Pregnancy Complications
Folic Acid
Vitamin B Complex
Growth Substances
Physiological Effects of Drugs


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Episcopal Church Ecumenical Officer announces retirement
The Rt. Rev. C. Christopher Epting, Episcopal Church Presiding Bishop Katharine Jefferts Schori"s Deputy for Ecumenical and Interreligious Relations, has announced his retirement at the end of 2009.
"It has been a distinct privilege to serve two presiding bishops and this church in the ongoing quest for Christian unity," Epting said. "As we move into the future, ecumenical and interreligious work will have to be done differently, and fresh thinking will be necessary to see how this might best be accomplished."
"I am very grateful for Bishop Epting"s abundant and effective gifts in ecumenical and interreligious work over the last several years," commented Presiding Bishop Jefferts Schori. "We will miss him and his gifts."
According to the Presiding Bishop"s office, the Rev. Dr. Thomas Ferguson, associate deputy for Ecumenical and Interreligious Relations since 2001, will serve as interim ecumenical officer at Epting"s retirement.
Ferguson noted, "It's been a pleasure to work with Bishop Epting, and I am glad to serve as interim. Serving as associate deputy for the last eight years brings important continuity to our ecumenical partnerships. I have a strong commitment to the ecumenical and interreligious engagement of the Episcopal Church."
Bishop Christopher Epting
Epting was elected Bishop of Iowa in 1988 following 16 years as a parish priest in the Diocese of Central Florida. While Bishop, Epting focused on the ministry of all the baptized, the renewal of the diaconate, spiritual formation, and ecumenical relations both locally and nationally. He was a leader in the state council of churches, Ecumenical Ministries of Iowa, and chaired The Episcopal Church"s writing team on "Called to Common Mission" effecting full communion between The Episcopal Church and the Evangelical Lutheran Church in America.
In 2001, then Presiding Bishop Frank Griswold asked him to serve as ecumenical officer, marking the first time a bishop was given this responsibility. As ecumenical officer, Epting served on the Central Committee of the World Council of Churches, the Governing Board of the National Council of Churches, staffed bilateral dialogues with the Roman Catholic and Presbyterian churches, the Lutheran-Episcopal Coordinating Committee, and the Jewish-Christian dialogue of the National Council of Churches. From 2001 until 2009, he served on the Inter Anglican Standing Commission on Ecumenical Relations.
Epting is a graduate of the University of Florida and Seabury-Western Theological Seminary and holds an STM from General Theological Seminary.
Following his retirement as ecumenical officer, Epting will serve as interim dean of Trinity Episcopal Cathedral in Davenport, Iowa.
The Episcopal Church, with 110 dioceses in 16 nations, is a member province of the worldwide Anglican Communion.
The Episcopal Church: www.episcopalchurch.org
Ecumenical and Interreligious Relations: http://www.episcopalchurch.org/eir.htm
IamEpiscopalian: http://www.iamepiscopalian.org/
Facebook: http://www.facebook.com/episcopalian
Twitter: http://twitter.com/iamepiscopalian
YouTube: http://www.youtube.com/TECtube


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The search found 2 results in 0.01 seconds.
Fall 2016 Vol. 15 No. 4
Features include "Financial Foreclosures," "Fat Eggs or Fit Bodies," "God's Case for Sex," "Revisiting the Rationing of Medical Degrees in the United States," and "Activating Politics with Poetry and Spoken Word."
Winter 2018, Vol. 17, No. 1
Features include "After Charlottesville", "Ethnonationalism and the Rise of Donald Trump", "Trump's Immigration Attacks, in Brief", "Making Protest Great Again", "Emasculation, Conservatism, and the 2016 Election", "Maintaining Supremacy by Blocking Affirmative Action", and "The Algorithmic Rise of the "Alt-Right."


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This black and white antique map of the Valley of the Orinoco River was published in February 1896. Its full title is "Map of the Valley of the Orinoco River, Showing the Extent of Territory Drained by that Waterway and the Bearing it has on the Venezuelan Question." Of particular note on this map is the proposed Panama Canal.
Coverage Area: Orinoco River, Venezuela, Columbia, Panama, British Guiana


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At Mouseprice we perform valuations on all properties matching Gibbs Crescent Oxford.Currently, we can provide valuations on 77, across a range of prices: from £397,000 to £483,000 - Average price £439,389
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To find out more visit our property guides section.


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This was published 6 years ago
CBA facing $200m class action for 'bad advice'
Commonwealth Bank of Australia could face a class action brought by thousands of disgruntled investors who lost millions following bad financial planning advice and systemic manipulation.
If an action is brought, the bank could face a damages claim of up to $200 million following an investigation by plaintiff law firm Shine Lawyers.
The allegations were revealed earlier this month in a joint Fairfax and Four Corners investigation which laid bare the conduct of banned financial planner Rollo Sheriff, and the millions lost by his clients.
Following the press coverage Shine was approached by a number of investors who had lost money through the financial planning arm of the bank due to "bad financial advice", according to Shine partner Sasha Ivantsoff.
"Shine is now investigating a potential class action on behalf of up to 3000 investors whose money was placed into Commonwealth Bank of Australia products through its wholly owned subsidiaries Financial Wisdom, Commonwealth Financial Planning, Colonial Life Insurance, CommInsure and Colonial First State Investments," Mr Ivantsoff said.
If a class action were to be brought it would solidify the fears of corporate Australia and non-executive directors that negative press has the ability to translate into a damages suit, creating exposure for the company and a diversion of management time as well as reputational damage and ongoing legal costs.
In the case of CBA, the compensation figure of $200 million would be harmful to the company in itself, as well as the lost business associated with the financial planning arm and the negative publicity associated with alleged systemic manipulation.
A spokesperson for the bank said CBA does not comment on rumour and speculation.
Liability under licence
While no exact case has yet been formulated, Mr Ivantsoff said the investigation will focus on the liability of CBA for the advice given to investors in relation to its Australian financial services licence and the responsibility which flows from that. It is expected to take about one month.
A number of clients who lost money believed they were dealing with CBA, Mr Ivantsoff said, and "the products sold to them were by and large CBA products, particularly CBA margin loans, CBA insurance products or other CBA investment products".
"At no stage did the CBA, or anyone else, advise them that they were dealing with anyone other than CBA," he said, which is most likely to amount to a misrepresentation or product liability case.
CBA owns Financial Wisdom, which held the financial services licence for Meridien Wealth, out of which Mr Sheriff practised until 2010 when he was banned by the Australian Securities and Investments Commission (ASIC), and was therefore could be liable for the standard of advice dished out.
"This liability could include breaches of fiduciary duty, breach of the duty to use reasonable care and skill in providing the advice, misleading or deceptive conduct or unconscionable conduct," Mr Ivantsoff said.
The crux of the claims against Mr Sheriff that form the basis of the investigation are that he cultivated investors who agreed to invest their life savings with him in safe products, before later advising them to shift to high-risk, high-fee paying CBA products. This, it is alleged, was inappropriate advice causing clients to lose millions of dollars.
An allegation which has the potential to be extremely damaging is the suggestion that manipulation of clients risk profiles was systemic, and planners were able to override the profile in order to invest in riskier products.
An inter-company memo allegedly "contains a direction to staff on the basis that all plans including a proposal for a margin loan are to be prepared on the basis that the client would be servicing the loan 'irrespective of the actuality'," Mr Ivantsoff said.
"This was the way in which the rogue planners beat the system to put clients into geared products when such products were unsuitable for those clients."
Compensation 'not adequate'
CBA has since sold the subsidiary Meridien Wealth, which is now owned by Premium Wealth Management and headed by David Adiseshan, who is assisting Shine Lawyers with their investigation.
It is not the only litigation Commonwealth is facing over its financial planning business: the bank has also come under fire for rogue financial planner Don Nguyen, who allegedly lost clients millions of dollars.
Maurice Blackburn launched a class action on behalf of investors against the bank, alleging breach of contract and misleading and deceptive conduct under ASIC legislation, but the claims were resolved out of court once a favourable compensation regime was offered by the bank.
A senate inquiry was subsequently commenced with hearings taking place last year.
Some clients in both Mr Sheriff's and Mr Nguyen's schemes accepted compensation offers and are now bound by confidentiality, but Mr Ivantsoff said there are plenty who have not taken up those offers.
Ninety-eight investors who bought into an unsuccessful biodiesel scheme run by Mr Sheriff have been compensated to some extent, "but we are not convinced that the compensation was adequate and there may be a basis to set aside settlement agreements on a Contracts Review Act or unconscionable conduct basis", Mr Ivantsoff said.
Others who were advised into double- or triple-gearing assets, or who entered into margin loans, had not received any money.
The biggest limit to the class action is expected to lie in the statute of limitations which is six years, meaning claims before 2008 are not actionable.


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For HBO, a la Carte Programming Is Still a Ways Off, Says Eric Kessler
Eric Kessler has worked at HBO for more than two decades in various capacities, overseeing everything from program licensing to digital strategy and marketing. He's been in the business a long time, seen the pay-TV programming evolution firsthand, and played a role in it, as well.
Put it this way, he's the guy who came up with the slogan "It's Not TV. It's HBO." — after a decade, it remains part of the cable TV vernacular. Today, he's got his hands full mapping out a viable digital strategy while remaining tethered to the cable-TV cash cow and fending off new rivals like Netflix and Amazon that are mounting assaults on its business.
As the first order of business at today's D: Dive Into Media interview, Kessler confirmed that HBO's HBO Go App is now compatible with Apple's AirPlay, and HBO subscribers who have been pining to stream HBO shows from their iOS devices to Apple TV can now do so. "Our long-term plan for Go is to be across all devices, and effective today, we will be enabling AirPlay," Kessler said, adding that Apple TV support will follow "at some point."
At some point.
And when that day comes, might it be accompanied by a la carte programming? At some point. But Kessler argued that the time for that is still quite a ways off. The economics simply aren't there.
"In marketing HBO, we are targeting the people who most love TV," Kessler said. "There are 70 million households that love television. And the average HBO household watches far more TV than the average TV household. So we are targeting the people who are most likely to buy our product."
Makes sense, but why not also target the fast-growing audience that wants HBO untethered from the TV? Simple. It's too expensive.
"Is there a broadband segment that wants HBO?" said Kessler. "Yes, of course. But when you look at penetration rates, at disconnect rates, at infrastructure and marketing costs, the economics are just not particularly compelling … That doesn't mean that's not going to change at some point, though."
So, for now, HBO Go will remain largely as it is today: You've got to be a subscriber to use it. That might seem unnecessarily limiting, but Kessler said HBO still gets a lot out of it, even if it's not bringing in money as a cord-cutter subscription service. It serves an important marketing function. People who watch HBO programs on HBO Go are generally more apt to talk about it online (obviously). "HBO Go usage seems to engage people in social conversation about these shows," Kessler said. "'Girls' viewership increases as more people talk about it on Twitter and Facebook."
What about other emerging schemes for building viewership? Netflix has recently been in the news quite a bit for its "House of Cards" series, which the company released as a 13-episode bundle. That's a strategy HBO has embraced for its archival programming, as well, and with a great deal of success. Viewers can use it to catch up on old seasons of their favorite series — obviously, there's a great deal of value for some in binge-viewing five seasons of "The Wire" back to back.
"When we launched the browser version of HBO Go, we only had about 400 hours of content," Kessler said. "When we launched the app, we decided to put every episode of every season up there. And what we have seen over the last two years is that the people who use the app will binge-view. They'll watch stuff to catch up. But that's the edge case."
So, is it wise to give a brand-new series like "House of Cards" that stuff-yourself-silly treatment? Kessler seemed dubious. Serializing shows in the old-school TV way plays a big role in building buzz, he explained. If you offer a series in its entirety when it debuts, you forfeit that "Who Shot J.R.?" anticipation. Just think about that final, infamous episode of "The Sopranos."
"The finale of 'The Sopranos' was one of the most talked-about finales in the history of television," Kessler said. "That show was on the cover of newspapers the next day. It was being talked about on morning radio and TV. If we had distributed the season all at once, we would have lost that."


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Published in March 1971 with an article entitled "Pagan, on the Road to Mandalay" and a fascinating supplemental map featuring "The Peoples of Mainland Southeast Asia," this vibrant and detailed map of Asia is presented in classic National Geographic style. Of particular note is the attention paid to the oceans, with colorful shading denoting depth and details of currents and prevailing winds.
Coverage Area: Asia, northern Europe


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EPA Commends Corporate Leaders for Major Greenhouse Gas Reductions
Release Date: 12/02/2009
Contact Information: Dave Ryan(News Media Only) email@example.com 202-564-7827 202-564-4355
WASHINGTON — EPA is recognizing eight companies for achieving significant goals to reduce greenhouse gas (GHG) emissions through the agency's Climate Leaders program. Twenty-seven companies are also being commended for announcing aggressive GHG reduction goals.
Combined, the Climate Leaders companies are reducing greenhouse gas emissions by approximately 50 million metric tons of carbon dioxide equivalents per year.
"EPA's Climate Leaders are sending a clear message that the choice between our economy and our environment is a false choice," said EPA Administrator Lisa P. Jackson. "They're doing their part in the fight against climate change and giving consumers the power to support environmentally responsible choices. That leads to a better bottom line and a brighter future for everyone."
Anheuser-Busch Companies, Inc., Bank of America Corp., Coors Brewing Company, Eastman Kodak Company, First Environment, Inc., Gap Inc., Roche Group U.S., and Shaklee Corp. have achieved long-term GHG reduction goals, and three of these companies have also made new commitments to further reduce their emissions.
As the country's largest GHG goal-setting program, Climate Leaders is an EPA industry-government partnership that works with companies to develop comprehensive climate change strategies. Launched in 2002, the program has expanded from 11 charter members to over 275 participants, which together represent more than eight percent of total annual U.S. GHG emissions. Program partners represent a broad range of industry sectors with a combined annual revenue equal to 12 percent of the U.S. gross domestic product.
The Climate Leaders Small Business Network was recently launched to deliver GHG management assistance to organizations with fewer emissions.
Complete list of partners and their goals: https://www.epa.gov/climateleaders/partners
Search this collection of releases | or search all news releases
View selected historical press releases from 1970 to 1998 in the EPA History website.