text:
#149 of 181
Lake Forest, CA
Comment, Like, Favorite
Wet River Rocks
Michael Ledray
Photograph - Digital Photographs
Low Key Studio Shot of black shiny rocks with water-drops on them Isolated on black
January 25th, 2011
Viewed 16,944 Times - Last Visitor from Beverly Hills, CA on 01/28/2020 at 1:05 PM
Sales Sheet
Toronto, ON - Canada
Belgrade, Se - Yugoslavia
Briliant sense of texture!
Bradfordwoods, PA - United States
Beautiful image!
Fontanella - Italy
Great work, Michael! I am following you. Liked/Favorited
Porthcawl, Mi - United Kingdom
More congratulations!
Santa Monica, Ca - United States
Congratulations on your sale!
Zelenograd - Russian Federation
Wonderful work! Congrats on your sale!
Pune, Ma - India
Congratulations on your sale!
Magog, QC - Canada
Congrats on your sale!
Bremen, HH - Germany
Lake Forest, CA - United States
Thanks Guys!
Philadelphia, PA - United States
Congrats on your sale!!!!
Fort Myers, Fl - United States
How do you change your profile picture on here?
Preston, La - United Kingdom
Great image!
Martinez, Bu - Argentina
Congrats on your sale!!!! f
Kailua Kona, HI - United States
Beautiful! Congrats on your sale!
Lake Forest, CA - United States
Thank you Robin.
Tappan, NY - United States
Love this :)
London, H9 - United Kingdom
Yes, it is really very, very nice! But the Nice is Nature not the work! Congrats on your sale!
Silute, Si - Lithuania
Nice work. Congrats on your sale!
Killeen, TX - United States
Simple, yet nice.....congrats on your sale!!!
Matawan, NJ - United States
Congratulations on your sale!
Voorhees, NJ - United States
Congrats on your sale!!!
Lake Forest, CA - United States
Thank you one and all Mike
Brooklyn, NY - United States
Terrific image~
Menges - Slovenia
Beautiful photo! Refreshing. V
New Hope, MN - United States
Nice. V
Cabool, MO - United States
Beautiful image. Nicely done
Minneapolis, MN - United States
Love this capture. Nice work.
Dobrich, Do - Bulgaria
Beautiful work!
Kochi, ke - India
what a great work, congrats for sale
Lake Forest, CA - United States
Thank you So very much one and all. :)
Lake Forest, CA - United States
Thanks for the info on how to delete these spam comments Mike
Rancho Santa Margarita, CA - United States
Congrats Mike on your sale!
Storybrooke, ME - United States
Congratulations on your sale Mike!
Saint Petersburg, RU - Russian Federation
Lake Forest, CA - United States
Thank You, One and All. It means so much to read the nice comments from each of you. I truly appreciate them. Now if we can just Block the Spammer. :)
Yorba Linda, CA - United States
congratulations on your sale!
B.S., MO - United States
Congrats on your sale!
Alexander, NY - United States
Great image congrats on the sale.
Lake Forest, CA - United States
Thank You so very much to Everyone for the nice comments. That means alot to me. :)
Pavilion, NY - United States
Love this shot! Very calming...would be great in a spa...Congrats on your sale! :-)
Shingle Springs, CA - United States
Very Nice
Worcester, MA - United States
Such a calm and smooth feeling :) Great job on all the water droplets and the rock striations!
Richmond, BC - Canada
nice shot
Cairo, 11 - Egypt
wooooooooooooooooooooooooooooooooooooooooooooooow vwey nice
Sydney, NS - Australia
Michael, you can delete my comment now, and the two above....reported to faa support now....
Lake Forest, CA - United States
oh by the way, anyone in the Southern California Orange County area and has a wedding, birthday or any party type event comming up, please check out my latest business www.partytimephotobooth.org Thanks again for all the nice and funny comments :) Rock On everyone! (sorry I had to say it, infact you might say it was Hard not to) ok ok I hear you groaning at my corney humor have a great weekend
Please Wait...
Sign up for our newsletter for exclusive deals, discount codes, and more.
Server Status OK
Copyright © 2020 Licensing.Pixels.com - All Rights Reserved


text:
Colourful Creatures Felt Tip Stamp Pens (set Of 18)
- Sign up for special offers and news *
- Speedy tracked delivery
- 30 day returns (conditions apply)
Great for creativity on the go, these fun rainbow coloured felt tip pins each have a unique stamp. The stamp and felt tip are on opposite ends of the pen, and both have their own ink. In a handy Colourful Creatures box this little art kit is easy to take with you on holidays or travels.
- 18 rainbow colours including black
- Handy carry case
- Not for children under 3 years.
- Material: Plastic, Ink
- Dimensions: Length: 10 cm
Returning unwanted items:
You can return your purchase for a refund within 30 days of receiving it. Simply post the item/s back to us with the completed returns form. Items must be unused and with tags intact. Note that you will be responsible for the cost of returning an unwanted item.
Returning damaged or faulty items:
Before returning the product you must contact customer services and inform us that you would like to return a faulty, damaged, or incorrect item. You can send the item back to us free of charge and will receive a full refund.
Read our full returns policy for more detail
|Shipping options
|Expected delivery period
|Delivery charge
|Terms and Conditions
|Standard UK delivery
|up to 10 working days during the Winter Sale
|Tracked DPD UK delivery
|up to 10 working days during the Winter Sale
|Expedited UK delivery
|International delivery

subset: commoncrawl


text:
Using Your Garden Shed for Garden Things
If you don't have a garden shed, you might want to consider getting one. It's perfect for storing garden tools, lawnmowers, and other garden equipment.
Getting Ready for the Winter
Wood shed in small garden area Notes: Winter is just around the corner. Time to get your wood shed filled up. Wood sheds are perfect outbuildings for storing winter firewood.
Wooden Shed for Storing Garden Tools
Garden with gardening tools and wooden shed for storage Notes: For the yard enthusiast, there are plenty of garden tools that need to be stored and organized. Many homeowners use


text:
My Jewish Family History Told Through Food
Three very different stories of food and Jewish heritage.
Public radio pieces and podcasts produced by Feet in 2 Worlds' team
Three very different stories of food and Jewish heritage.
New voices telling immigrant food stories.
A restaurant reveals a little-known story of the Korean diaspora.
Stories from the latest Fi2W food journalism workshop
A bittersweet story of strength, forgiveness and tenacity
Undocumented people weigh the costs and benefits of the municipal ID card.
A young Muslim woman defies expectations to create her own path.
A radio feature on NPR's Here and Now by Fi2W's Shagana Ehamparam
An audio portrait of India Home, a center for South Asian seniors in New York City
A sound-rich journey into a world full of surprises.


text:
Pictured Above is "Chiquita" Ch Chapford South of the Border.
The dynamo of our household who we love dearly, this blue bitch has just produced a silver girl "Rita" Chapford Del Riago.
Chiquita is a Reserve Challenge winner at Melbourne Royal and a multi in group and in show winner.
Chiquita is now retired to a well deserved life of comfort on the lounge watching tv in a new home in surrey hills
28/9/12 sad news today Chiqiuta has passed away she has crossed the rainbow bridge to be with Mark
she was just short of her 12th birthday God bless your little soul we all loved you
Graphics by Shawna
All Content Copyright
Dogz Online - Dogs, Breeders, Puppies


text:
What we do
Related work
The marketing world today is vastly different from ten years ago, or even last month. But while everything is changing, some things never change. Like the person on the other side of your message and the need for creative thinking that attracts, engages and compels them into action. This is the power of a great idea. But a great idea only takes you so far. Breaking through the marketing blinkers of today's audiences requires an in-depth understanding of how we consume media today (and how we'll consume it tomorrow). Couple this with a shareable, loved or powerful idea, and we can move people.
What we do
Creative Campaigns
Anyone who says digital has changed everything needs to take a breath. It hasn't. Advertisers still need emotionally engaging campaigns, only now they need to run on digital platforms as well. What has changed is how creative agencies create and execute the work to make it effective. There are more skills required to make work that moves people today. Creating effective and award-winning digitally led campaigns is something YoungShand has been refining for almost ten years.
Always On Comms
Unlike traditional campaigns that run and then disappear, always-on comms hang around and wait for your target consumer to interact with them. There are always new consumers in the market so your marketing needs to be there too. The messaging can be tailored depending on what they see and when, and what they do (or don't do) after seeing it. Creating effective always-on campaigns takes specialist experience, great creative and digital media smarts, to get your message seen by the right consumer at the right time.
Content Marketing
The YoungShand content team includes a full-time Director of Photography, a 2D/3D motion graphics animator, as well as a talented creative department. This means we can create virtually any type of content you might need, in-house, quickly and cost effectively.
Related work
websites | film
Making Blind Foundation services headline news
The News Crew Swap demonstrates what blind and low vision Kiwis can do with the right support. Including running a live newsroom.
There's a growing appetite from the public to know where their bacon comes from. So we did just that.
A new campaign you need to run? We're happy to show you our approach on how to deliver strong engaging campaigns that drive results.


text:
Even before discovering an obsession with skin-care products, you were probably familiar with aloe vera. Bottles of the stuff are so ubiquitous in the world of after-sun care that it's hard to imagine a summer without aloe. Even in an all-grown-up beauty routine, aloe has a major presence as a gentle skin soother. But the all-natural ingredient has just been included on a list that calls into question whether "natural" is synonymous with "safe" for your skin when it comes to aloe vera.
"The pulp of the aloe plant is water-rich, soothing, and hydrating to the skin," Joshua Zeichner, director of cosmetic and clinical research in dermatology at Mount Sinai Hospital in New York City, tells Allure. "It is commonly used for sunburns and [soothing] common irritation because of these properties." But, according to cosmetic chemists, the plant's soothing properties are questionable.
"Aloe vera has long been regarded as a nice ingredient for healing and moisturization by folklore," Ginger King, cosmetic chemist, tells Allure. "However, it's now on Prop 65 in California." Proposition 65, which added a specific version of aloe vera to its list in 2015, is officially known as the Safe Drinking Water and Toxic Enforcement Act of 1986 and is intended to protect people from chemicals known to cause cancer.
Currently, the FDA prohibits or restricts just 11 substances in cosmetic products (though there's currently a bill in Congress that's trying to expand the list), meaning all sorts of chemicals and bad-for-your-skin ingredients can technically make it into your beauty products. Prop 65 is a California state law that helps keep you in the know, by regularly updating a list of ingredients linked to cancer and requiring companies to label products containing any Prop 65 ingredients that you might be exposed to.
So, what is a totally natural ingredient like aloe vera doing on the list? Aloe comes in different forms both naturally and in products (decolorized aloe, aloe latex, aloe water, the sap-like gel that comes straight from the leaf). Prop 65 only calls out "non-decolorized, whole-leaf extract," which is "the liquid portion of the aloe vera leaf (e.g., what remains after removal of fibrous material, such as lignified plant fibers), and is a natural constituent of the aloe barbadensis Miller plant," according to the American Herbal Products Association.
Here's why: Non-decolorized, whole-leaf aloe extract contains a chemical called aloin, which has been shown to cause cancer in rats. There's one major caveat here, though: The study found aloin causes cancer only when ingested. In other words, the worrisome kind of aloe included on the list isn't actually relevant to your favorite beauty products. To be totally clear, there is no evidence that aloe applied to the skin can causes cancer.
Still, according to the experts, even the aloe that is in your moisturizer is raising some eyebrows. "Many people believe that it has been proven that aloe can heal skin. But there is actually little scientific evidence that it is effective," Perry Romanowski, cosmetic chemist and cofounder of The Beauty Brains, tells Allure. He says claims like aloe's "anti-inflammatory properties, wound-healing ability, and reduction of radiation damage have all been unproven," but that's not entirely true. While minimal, there has been some research done that says otherwise.


text:
Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion channel genes, may be of interest in this respect in the context of bipolar disorder. In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission and calculated all combinations of three genotypes from the 3×803 SNP genotypes for 1355 controls and 607 patients with bipolar disorder. Four clusters of patient-specific combinations were identified. Permutation tests indicated that some of these combinations might be related to bipolar disorder. The WTCCC bipolar dataset were use for replication, 469 of the 803 SNP were present in the WTCCC dataset either directly (n = 132) or by imputation (n = 337) covering 51 of our selected genes. We found three clusters of patient-specific 3×SNP combinations in the WTCCC dataset. Different SNPs were involved in the clusters in the two datasets. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder.
Citation: Koefoed P, Andreassen OA, Bennike B, Dam H, Djurovic S, Hansen T, et al. (2011) Combinations of SNPs Related to Signal Transduction in Bipolar Disorder. PLoS ONE 6(8): e23812. https://doi.org/10.1371/journal.pone.0023812
Editor: Pieter H. Reitsma, Leiden University Medical Center, The Netherlands
Received: June 21, 2010; Accepted: July 28, 2011; Published: August 29, 2011
Copyright: © 2011 Koefoed et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: The study was supported by the Lundbeck Foundation, the Danish National Psychiatric Research Foundation, A. P. Moeller and Hustru Chastine Mc-Kinney Moellers Foundation, Ivan Nielsen Foundation, Stanley Research Foundation, Stanley Medical Research Institute, grants to the TOP study group from the University of Oslo, the Research Council of Norway, and the South East Norway Health Authority. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
Bipolar disorder (BD) is a severe psychiatric disease generally characterized by repeated manic and depressive episodes. The time of onset varies, but it usually begins between the ages of 15 and 25 years, affecting men and women equally with a lifetime prevalence of 1.5% [1]. Family, twin, and adoption studies have shown that genetic factors contribute to BD, but the involved genes have not yet been identified. This may partly be explained by a genetic architecture characterized by both genetic heterogeneity (at the population level) and polygenic interactions (at the level of the individual) [2]–[5]. Locus heterogeneity in a disease may occur when dysfunctions in different mechanisms each produce the symptoms characterising the phenotype.
In the search for disease-associated genes, high-throughput genotyping methods have allowed analysis of a large number of single nucleotide polymorphisms (SNPs), but most of these studies have used single-locus analysis strategies. Yet, many common diseases have complex aetiologies that may involve combinations of SNPs from different genes and, possibly, different combinations within the population of affected individuals. The growing interest in interactions and their contribution to risk for complex diseases has resulted in a search for methods of calculating disease-related interactions of two or more SNPs [6]. Most of these methods are theoretical, and many concentrate on finding combinations of two SNPs [7]–[10]. Only a few studies have looked at combinations of more SNP genotypes; for example, Xie et al. [11], in a study of oesophageal cancer, analysed SNP genotypes from genes related to DNA repair mechanisms and liver function and identified combinations of genotypes relevant to the disease. In the quest for alternative approaches in the search for interacting SNPs, interest has grown in pathways with an enrichment of associated signals [12]–[15]. These methods are robust to the detection of enrichment that derives from genetic heterogeneity at the population level or from gene- or protein-interactions at the individual level.
In BD, hyperactivity is the main symptom of the manic phase, and this clinical phenotype may reflect altered activity at the cellular or molecular level that leads to faster signal transmission in the brain. Numerous mechanisms are involved in signal transmission, suggesting that the mania phenotype may result from many different dysfunctions in mechanisms relevant to signal transmission velocity in the nervous system; this concept is in agreement with the genetic heterogeneity of BD [2], [3]. We previously suggested that propagation of nerve impulses may be faster in mania than in a normal affective state [16], which is in agreement with a number of similar hypotheses proposing mania as a disorder of ionic conductance of nerve cell membranes [17], nerve cell excitability [18], [19], action potential firing [20], neuronal hypersynchronization [21], changes in sodium pump number [22], membrane abnormalities [23], and cortical instability [24]. Furthermore, the suggestion that nervous system hyperactivity may play a role in BD is in accordance with the fact that several drugs used to treat epilepsy are effective in the treatment of mania.
We have investigated genes (1) related to the action potential, where we focused on genes related to the architecture of the sodium channels in the nodes of ranvier and CNS myelination [19], [25]–[29]. Among these genes, we have selected those (2) that occur in loci considered to be of interest with respect to BD, as indicated by linkage analyses [30], [31]; (3) that encode proteins that are targets for mood-stabilizing drugs [29], [31], [32]; or (4) that previous studies have shown are associated with BD [19], [26], [29], [31]. Many genes in this group are related to ion channels, an observation that agrees with the finding of Askland et al. [12] that variation in ion channel genes may contribute to susceptibility to BD.
In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission and calculated all combinations of three genotypes (the normal homozygote, the heterozygote, and the variant homozygote, respectively) from the 3×803 SNP genotypes. We likewise calculated all combinations with three SNP genotypes from the genome wide association study (GWAS) performed by the Wellcome Trust Case Control Consortium (WTCCC) [33] using SNPs analysed in both datasets. We found 132 SNPs that were genotyped in both studies, by imputation we obtained additional 337 SNPs with a good quality, thus 469 SNPs were among our 803 SNPs and available for validation.
Calculation of single SNP association
803 SNPs in 55 genes (see Table 1) were analysed and a Chi-square test (or Fishers exact test when appropriate) was performed for each SNP. The genotype distribution was significantly different (p<0.05) between control persons and patients for 86 SNPs (see Table S1), but none remained significant after a Bonferroni correction.
Combination of two SNPs
Combinations of two SNPs from 803 SNPs results theoretically in 803!/2!(803−2)!×9 = 2,898,027 combinations, whereas the actual number in the material was 2,770,033 combinations. Chi-square test for each of these combinations was not performed, but 1000 permutation tests showed that combinations found exclusively in the patients (161,070 combinations) could be random.
Combinations with three SNPs
Combinations of three SNP genotypes from the 803 SNPs results theoretically in 803!/3!(803−3)!×33 = 2,321,319,627 combinations of three-SNP genotypes (in the following to be termed 3-combinations) (Table 2). The actual number of 3-combinations of genotypes found in our material (1962 individuals) was 1,985,613,130. Most, namely 1,719,002,329 of these 3-combinations (87%) were common for both control persons and patients, whereas 208,699,590 3-combinations were found in control persons only, and 57,911,211 3-combinations were found in patients only (Table 2). The number of patient-specific 3-combinations shared by several patients decreases as the number of patients in a group increases (Table 2). When the number of patients was nine or more, only 1181 3-combinations of the 57,911,211 patient-specific 3-combinations remained. In order to see if the subgroup of 1181 3-combinations may be of importance for BD, 1000 permutation tests of the complete material were calculated, and it was found that 1181 3-combinations shared by nine or more patients might be a random finding (found 113 times; p = 0.11).
Among the 1181 3-combinations, many genotypes were part of one or two 3-combinations and only a few genotypes occurred in more than ten 3-combinations. However, we observed that four genotypes (AVPR1B_rs33976516 = 1 (one indicate heterozygocity), KCNN3_rs884664 = 2 (two indicate homozygosity for the minor allele), CACNG2_rs2179871 = 2, KCNQ3_rs2469515 = 2) occurred in 46, 45, 49, and 32 3-combinations, respectively (Figure 1–4). The genotypes were all among the 86 SNPs showing a significantly different distribution between control persons and patients (nominal p-values were 0.013, 0.010, 0.023, and 0.017, respectively). Futhermore; these four observed subgroups of 3-combinations contained all the patients in the material (41, 48, 41, and 37 patients, respectively) having the four genotypes (Figure 1–4). Such subgroups characterised by relatively many 3-combinations sharing a defining genotype and containing all the patients having this genotype are called clusters. In 1000 permutation tests, at least one cluster of this type (with at least 37 pseudo-patients) were seen 42 times (p = 0.042), two such clusters were seen 3 times (p = 0.003), and at least three or more clusters of this type did not occur once (p<0.001). Relatively little overlap between the patients in the clusters was observed, as only eleven of the patients were members of two clusters, and no patient was a member of three or four clusters. A total of 156 patients were involved in the four clusters.
a) 0: Normal homozygote; 1: Heterozygote; 2: Variant homozygote.
a) 0: Normal homozygote; 1: Heterozygote; 2: Variant homozygote.
a) 0: Normal homozygote; 1: Heterozygote; 2: Variant homozygote.
a) 0: Normal homozygote; 1: Heterozygote; 2: Variant homozygote.
All patients in a cluster shared the defining genotype, but nested within the four clusters, eleven smaller subgroups were observed. In these subgroups patients sharing the same defining genotype (e.g. AVPR1B_rs33976516 = 1) also shared a second genotype (e.g. ANK3_rs2288358) in combinations with four or more distinct third SNPs (shown in Figure 1–4 as the boxes in the third column). Considerable overlap between patients was found within these subgroups. In 1000 permutation tests only 49 subgroups of this type were found (p = 0.049). Additionally, within this type of subgroup, 12 even smaller subgroups were characterized by having the third genotype in the 3-combinations contributed by SNPs from the same gene (shown in Figure 1–4 as more SNP numbers in the same box). These 12 small subgroups together comprised 32 3-combinations. Only 19 3-combinations of this type were found in 1000 permutation tests (p = 0.019).
WTCCC data [33]
Of our 803 SNPs 132 were genotyped in the WTCCC bipolar disorder dataset [33]. In order to obtain more SNPs, we performed an imputation using impute2 on the chromosome regions surrounding our selected genes. We could impute 651 SNPs of our 803 SNPs, but after removing SNPs with a low quality we ended up with additional 337 SNPs, leaving 469 SNPs in common between our material and the WTCCC.
Chi-square test (or Fishers exact test when appropriate) was performed for each SNP. The genotype distribution was significant different (p<0.05) between control persons and patients for 51 SNPs (see Table S1), but none remained significant after a Bonferroni correction. Five of the 51 SNPs were among the 86 significant SNPs in our material (see Table S1).
The theoretically number of 3-combinations from the 469 SNPs is 461,262,438, while the observed number was 287,931,183. Most, namely 247,477,254 were seen in both controls persons and patients, whereas 16,762,350 3-combinations were found in control persons only, and 23,691,570 3-combinations were found in patients only.
Using the above mention criteria for a cluster, three clusters were observed among the patient-specific 3-combinations. The defining genotypes were NFASC_rs12737855 = 2, NFASC_rs7519658 = 2 and ANK3_rs6479700 = 2, containing 124, 135 and 182 combinations, and 159, 150 and 142 patients, respectively (data not shown). All three genotypes were among the 51 significant SNPs. In 1000 permutation tests, at least one cluster of this type (with at least 142 pseudo-patients) were seen 49 times (p = 0.049), two such clusters were seen 3 times (p = 0.003), and at least three clusters of this type did not occur once (p<0.001).
Within the three clusters, we again observed smaller subgroups where patients also shared the second genotype in six or more combinations, and there were a considerable overlap between the patients involved in these subgroups. In 1000 permutation tests only 29 of such subgroups were found (p = 0.029).
There was a substantial overlap between the patients in the two clusters with the defining SNPs belonging to the NFASC gene (n = 134), while only a limited number of patients belonging to the third cluster (defined by ANK3_rs6479700) were present in the two other clusters (n = 10 and n = 8, respectively, where eight were part of all three clusters).
Complex diseases may be associated with combinations of SNPs. A number of methodological and theoretical studies have addressed this statistical and data-mining challenge [7]–[15], [34], but clinical investigations using combinations of several SNPs are rare [11]. The problem with combinations is the large numbers created, which is computationally demanding, especially when permutation tests are used as a statistical method. Thus in the present study, with 803 SNPs and combinations of no more than three SNP genotypes at a time, we found 1,985,613,130 3-combinations, close to the theoretical maximum of 2,321,319,627 3-combinations. Due to the relative low number of subjects and genetic factors as allele frequency and non-independence of SNPs located in the same gene region, we had expected to find a smaller number of 3-combinations.
In an attempt to identify 3-combinations related to BD, only 3-combinations found exclusively in the patient group were examined in more detail in this study, meaning that only combinations with 100% penetrance were examined. Among the 1,7 billion 3-combinations common for control persons and patients many may be associated with disease; these combinations will be analysed separately. In the 58 million 3-combinations found exclusively in the patients, 45 million were singularities (found in one person only), raising the possibility that they were random. Following this line of reasoning, the 1181 3-combinations, shared by nine or more patients and no control person, may be the most promising in relation to BD, but permutation tests showed that these also might have been random. However, 172 of these 3-combinations were located in four clusters each characterised by a defining genotype, and by inclusion of all patients having this genotype. Occurrence of three or more clusters of this type was not found once in 1000 permutation tests, indicating that at least some 3-combinations in the clusters may be related to BD. In addition, subgroups within the four clusters also shared the second genotypes, and some had the third genotype in the 3-combinations located in the same gene, suggesting that accumulation of several genotypes in a single gene may be important for the disease susceptibility in some cases.
We found only 5 nominally significant SNPs in common between the Scandinavian material and the WTCCC material (see Table S1), indicating heterogeneity between the two samples. A cluster with the same defining genotype as in one of the four clusters observed in our material could not be found in the WTCCC material, as none of the four defining SNPs were present among the 132 genotyped SNP or the 337 imputated SNPs in the WTCCC dataset. However, three significant clusters were found. Again three of more clusters were not seen once in 1000 permutation tests. Also nesting 3-combinations sharing the two first genotypes was present in the WTCCC dataset (p = 0.029). An overlap in the clusters observed in the two dataset were not see in the 3-combinations exclusively found in patients, but may be found in the much larger group of combinations common for control persons and patients.
An examination of individual patient data in both sample sets shows that most of the patients carry many of the 3-combinations in the clusters although none had exactly identical pattern of 3-combinations, raising the possibility that each patient has a unique genetic background for the disorder. The subgroups of 3-combinations with overlap in patients, sharing two genotypes in more than four 3-combinations, are interesting because different SNP as the third (sometimes even from the same gene (in some cases in close LD)) leads to an accumulation of several genotypes in small group of patients. Such an accumulation may be important for the disease susceptibility.
Askland et al. [12] found that although the data from two large independent GWAS [33], [35] both pointed to ion channel genes as important for BD, only a modest overlap between the two studies was found for the involved genes. The authors suggested that prominent genetic heterogeneity might explain this modest overlap [12]. The present analyses of the 3-combinations of SNP genotypes support the explanation that genetic heterogeneity is prominent in the genetic architecture of BD. This heterogeneity is illustrated by the many patient-specific 3-combinations of SNP genotypes, some of which may be important for BD. The selection of genes in this study is based on their relation to some aspects of signal transmission in the brain, so obviously any combination of genotypes might be related to this function. However, a more narrow relationship may be seen in the cluster defined by KCNQ3 rs2469515 (Figure 4) together with ANK3 rs12049756 and three different SNPs from SCN2A (rs12469667, rs3769949, and rs997508); as the proteins translated from these genes all are located in the node of ranvier [25]. Similarly, in the largest subgroup defined by CACNG2 rs2179871 (Figure 3), and involving 13 combinations with KCNN3 rs6426998 as the second SNP, many of the nine different genes involved as the third SNP are implicated in the architecture of the sodium channels in the node of ranvier (e.g. SPTBN4, CNTNAP2, NFASC, SCN2A and ANK3).
Our study indicates that BD may show extreme genetic heterogeneity at the population level. At the same time the many 3-combinations in each patient may support gene-gene interactions or epistasis important for BD. However, such interactions probably will involve genes not analysed in the present study. A more profound discussion of functional connections between the genes participating in a combination remain speculative and is preliminary until more genes related to signal transmission are analysed and combinations of more than three genotypes can be carried out. The pronounced genetic heterogeneity and the number of possible interactions on the individual level both suggest that the biology of BD may be very complex; but on the other hand, if the genotypes behind the heterogeneity are associated with a limited number of functions the degree of complexity may be decreased.
Future direction
In this work we have looked at the combinations of three SNP genotypes that were observed in patients only. The next step is to look at the much larger number of combinations seen in both patients and controls. However, this may involve calculations of combinations with more than three SNP genotypes.
Materials and Methods
Patient sample
This study is based on two independent case-control samples from Norway and Denmark, included in the Scandinavian Collaboration of Psychiatric Etiology (SCOPE). The Danish sample consisted of 220 bipolar patients from the Copenhagen area, 162 bipolar patients in Jutland, and 1133 control participants. The sample from Norway included 222 controls and 225 bipolar patients. Thus, a total of 607 unrelated patients and 1355 unrelated healthy control participants were included. The Norwegian patients had been diagnosed according to the DSM-IV and the Danish patients according to ICD-10. The Norwegian and Danish healthy controls and cases have been described in more detail elsewhere [36], [37]. The Norwegian Scientific-Ethical Committees, the Norwegian Data Protection Agency, the Danish Scientific Committees, and the Danish Data Protection Agency approved the study. All patients gave written informed consent prior to inclusion in the project.
The genes, shown in Table 1, were selected based on the following criteria: (1) literature relating corresponding functional proteins to various aspects of the action potential (with focus on the architecture of the sodium channels in the nodes of ranvier and CNS myelination) [25]–[29], [38]–[41]; (2) occurrence in loci associated with BD, as indicated by linkage analyses [30], [31]; (3) encoding of corresponding proteins that are targets for mood stabilizing drugs [29], [31], [32]; and (4) identification in previous studies showing an association with BD [26], [29], [31], [41]–[43]. Additional we used information from different internet sources (www.ncbi.nlm.nih.gov/Database/; www.ensembl.org/index.html; www.pubgene.org; www.ensembl.org/index.html; www.string.embl.de; www5.appliedbiosystems.com/tools/pathway/all_pathway_list.php; www.reactome.org).
We prioritized genes fulfilling more than one criterion, but realize that other genes fulfil the criteria and thus could have been included instead. The genotyping were planned in the autumn of 2007 and preformed in the spring 2008.
SNP selection and genotyping
To cover most of the common variants with tagSNPs, we used a structured gene-wide approach, based on the HapMap CEU population. TagSNP selection was performed at the HapMap website using pair-wise tagging, with r2≥0.8 [44] (www.hapmap.org; HapMap Data Rel 22/phaseII Apr07) and minor allele frequency (MAF)≥0.05. Some SNPs (some with MAF<0.05) were selected if they resulted in a missense mutation or if they had been linked to BD. Not all selected tagSNP were genotyped, and exclusion was attributable to the following reasons: (1) a design score <0.4 for the Illumina Platform (n = 109); (2) failure during the genotyping analysis (n = 76); or (3) being discarded during quality control for several reasons [sample call rate <90%, more than three clusters seen in the result, and/or SNP not in Hardy-Weinberg equilibrium (HWE; p<0.001) (n = 94)]. This resulted in 803 SNP for analyses as described below.
Genomic DNA was extracted from whole blood. Most (796) SNPs were genotyped using the GoldenGate 1536plex assay (Illumina Inc.) on Illumina BeadStation 500GX at the SNP Technology Platform, Uppsala University, Sweden (www.genotyping.se), accredited by the Swedish accreditation agency SWEDAC, and approved according to a quality system based on the international SS-EN ISO/IEC 17025 standard. For the subset of SNPs used in this study, the reproducibility was 99.999% (there was one duplicate error in 70,098 duplicate genotype calls), and the average sample call rate per SNP assay was 99.6%. The four SNPs in YWHAH and the three SNPs in SCN1B were genotyped using TaqMan genotyping assays according to the manufacturer's instructions. For these, the reproducibility was 99.72%, and the average sample call rate per SNP assay was 98.4%.
Statistics and data processing
The samples were tested for population stratification by calculating the gene-based overall fixation index FST using Arlequin Software [36], [37]. The statistical significance of single genotype distribution was assessed using the Chi-square or Fisher's exact test, whereas patterns of SNP combinations were assessed by permutation tests.
Combinations of genotypes were calculated using array-based mathematical methods [45], [46], where data are represented geometrically, hereby facilitating parallel processing, which was performed using programs from Genokey (www.genokey.com) and Dyalog (www.dyalog.com).
Each of the 1000 permutation tests (in our dataset) were performed as follows: 1) A permutation of the entire population (i.e. indicies 1 to 1962) is determined. The result is a new vector with all indices 1 to 1962 in random order. 2) 607 random "patients" are selected, and the remaining 1355 individuals are "controls". 3) The cluster analysis on the 607 "patients" and 1355 "controls" is determined using exactly the same methods as previously on the biological samples. Likewise, permutation tests were performed in the WTCCC dataset with 1998 random "patients" and 1500 random "controls".
Imputation of WTCCC data
We obtained genotype data on the bipolar patients (n = 1998) and the UK blood service control group (n = 1500) from the WTCCC data [33]. We searched for SNPs genotyped in both samples and found 132. To get more SNPs in common for the two dataset, we performed imputation using Impute2 (mathgen.stats.ox.ac.uk/impute/impute_v2.html) [47], [48] of SNPs in the chromosome regions around our selected genes (with at minimum of 500 kb surrounding area). We used both the provided hapmap3 dataset and the 1000 genome project samples as reference samples resulting in "Ne" to be 15000. We used default setting with the following exception: we set "iter" to 40 and "k" to 100 to get better genotypes, we selected a call thresh hold to be 0.9, and set the result to include only the SNPs, that we have genotyped. Prior to the imputation we exclude SNPs from the WTCCC dataset, that WTCCC had excluded due to low genotyping quality. We only include imputated SNPs with a certain (more than 80% probability for a given genotype) genotype calling in more than 80% of the subjects.
Supporting Information
Table S1.
Nominal significant SNPs in the present sample as well as in the WTCCC dataset.
We thank patients and controls for their participation in the study and the health professionals who facilitated our work. We thank Kristina Larsson, Per Lundmark, Tomas Axelsson, and Ann-Christine Syvänen at the SNP Technology Platform in Uppsala for performing the genotyping. The SNP Technology Platform is supported by Uppsala University, Uppsala University Hospital, and by the Knut and Alice Wallenberg Foundation.
This study makes use of data generated by the Wellcome Trust Case-Control Consortium. A full list of the investigators who contributed to the generation of the data is available from www.wtccc.org.uk. Funding for that project was provided by the Wellcome Trust under award 076113.
Author Contributions
Conceived and designed the experiments: PK EM. Performed the experiments: PK BB GLM EM SD. Analyzed the data: PK GLM EM. Contributed reagents/materials/analysis tools: PK EM GLM. Wrote the paper: PK OAA EM. Designed the software used in analysis: GLM. Collection of samples: HD IM LVK MBJ OAA OM TH TW.
- 1. Barnett JH, Smoller JW (2009) The genetics of bipolar disorder. Neuroscience 164: 331–343.
- 2. Faraone SV, Tsuang MT (2003) Heterogeneity and the genetics of bipolar disorder. Am J Med Genet C Semin Med Genet 123: 1–9.
- 3. Zandi PP, Badner JA, Steele J, Willour VL, Miao K, et al. (2007) Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates. Mol Psychiatry 12: 630–639.
- 4. Thornton-Wells TA, Moore JH, Haines JL (2004) Genetics, statistics and human disease: analytical retooling for complexity. Trends Genet 20: 640–647.
- 5. Tang B, Thornton-Wells T, Askland KD (2011) Comparative Linkage Meta-Analysis Reveals Regionally-Distinct, Disparate Genetic Architectures: Application to Bipolar Disorder and Schizophrenia. PLoS ONE 6: e19073.
- 6. Cordell HJ (2009) Detecting gene-gene interactions that underlie human diseases. Nat Rev Genet 10: 392–404.
- 7. Garcia-Magarinos M, Lopez-de-Ullibarri I, Cao R, Salas A (2009) Evaluating the ability of tree-based methods and logistic regression for the detection of SNP-SNP interaction. Ann Hum Genet 73: 360–369.
- 8. Wu J, Devlin B, Ringquist S, Trucco M, Roeder K (2010) Screen and Clean: A Tool for Identifying Interactions in Genome-Wide Associations Studies. Genet Epidermiol 34: 275–285.
- 9. Yang C, He Z, Wan X, Yang Q, Xue H, et al. (2009) SNPHarvester: a filtering-based approach for detecting epistatic interactions in genome-wide association studies. Bioinformatics 25: 504–511.
- 10. Yang C, Wan X, Yang Q, Xue H, Yu W (2010) Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso. BMC Bioinformatics 11: Suppl1S18.
- 11. Xie Q, Ratnasinghe LD, Hong H, Perkins R, Tang ZZ, et al. (2005) Decision forest analysis of 61 single nucleotide polymorphisms in a case-control study of esophageal cancer; a novel method. BMC Bioinformatics 6: Suppl2S4.
- 12. Askland K, Read C, Moore J (2009) Pathways-based analyses of whole-genome association study data in bipolar disorder reveal genes mediating ion channel activity and synaptic neurotransmission. Hum Genet 125: 63–79.
- 13. Hong MG, Pawitan Y, Magnusson PK, Prince JA (2009) Strategies and issues in the detection of pathway enrichment in genome-wide association studies. Hum Genet 126: 289–301.
- 14. O'Dushlaine C, Kenny E, Heron E, Donohoe G, Gill M, et al. (2011) Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry 16: 286–292.
- 15. Zamar D, Tripp B, Ellis G, Daley D (2009) Path: a tool to facilitate pathway-based genetic association analysis. Bioinformatics 25: 2444–2446.
- 16. Mellerup E, Kristensen F (2004) Mania as a dysfunction of reentry: application of Edelman's and Tononi's hypothesis for consciousness in relation to a psychiatric disorder. Med Hypotheses 63: 464–466.
- 17. Thiruvengadam A (2001) Effect of lithium and sodium valproate on resting membrane potentials in neurons: an hypothesis. J Affect Disorders 65: 95–99.
- 18. Saugstad LF (2001) Manic depressive psychosis and schizophrenia are neurological disorders at the extremes of CNS maturation and nutritional disorders associated with a deficit in marine fat. Med Hypotheses 57: 679–692.
- 19. Askland K, Parsons M (2006) Toward a biaxial model of "bipolar" affective disorders: spectrum phenotypes as the products of neuroelectrical and neurochemical alterations. J Affect Disord 94: 15–33.
- 20. Newton JR (1999) Manic-depression neural conduction speeds and action potential event dyscorrelation. Med Hypotheses 52: 77–83.
- 21. Alvarez J (2001) Neuronal hypersynchronization, creativity and endogenous psychoses. Med Hypotheses 56: 672–685.
- 22. Banks RE, Aiton JF, Naylor GJ, Cramb G, Wright AF, et al. (1989) Cation transport in lymphoblastoid cell lines established from bipolar manic-depressive patients. J Affect Disorders 16: 259–267.
- 23. Pettegrew JW, Nichols JS, Minshew NJ, Rush AJ, Stewart RM (1982) Membrane biophysical studies of lymphocytes in manic depressive illness. J Affect Disorders 4: 237–247.
- 24. Hoffman RE, Quinlan DM, Mazure CM, McGlashan TM (2001) Cortical instability and the mechanism of mania: a neural network simulation and perceptual test. Biol Psychiatry 49: 500–509.
- 25. Poliak S, Peles E (2003) The local differentiation of myelinated axons at nodes of ranvier. Nature Review Neuroscience 4: 968–980.
- 26. Tkachev D, Mimmack ML, Ryan MM, Wayland M, Freeman T, et al. (2003) Oligodendrocyte dysfunction in schizophrenia and bipolar disorder. The Lancet 362: 798–805.
- 27. Rasbend MN (2004) It's "juxta" potassium channel! Journal of Neuroscience Research 76: 749–757.
- 28. Inda MC, DeFelipe J, Muñoz (2006) Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. PNAS 103: 2920–2925.
- 29. Carter CJ (2007) Multiple genes and factors associated with bipolar disorder converge on growth factor and stress activated kinase pathways controlling translation initiation: Implications for oligodendrocyte viability. Neurochemisty International 50: 461–490.
- 30. Askland K (2006) Toward a biaxial model of "bipolar" affective disorders: Further exploration of genetic, molecular and cellular substrates. Journal of Affective Disorders 94: 35–66.
- 31. Ogden CA, Rich ME, Schork NJ, Paulus MP, Geyer MA, et al. (2004) Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Molecular Psychiatry 9: 1007–1029.
- 32. Bosetti F, Bell JM, Manickam P (2005) Microarray analysis of rat brain gene expression after chronic administration of sodium valproate. Brain Research Bulletin 65: 331–338.
- 33. The Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661–678.
- 34. Boulesteix AL, Strobl C, Weidinger S, Wichmann HE, Wagenpfeil S (2007) Multiple testing for SNP-SNP interactions. Stat Appl Genet Mol Biol 6: Article 37.
- 35. Sklar P, Smoller JW, Fan J, Ferreira MA, Perlis RH, et al. (2007) Whole-genome association study of bipolar disorder. Mol Psychiatry 13: 558–569.
- 36. Kähler AK, Otnaess MK, Wirgenes KV, Hansen T, Jönsson EG, et al. (2010) Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples. Am J Med Genet B Neuropsychiatr Genet 5: 86–96.
- 37. Tesli M, Kähler AK, Andreassen BK, Werge T, Mors O, et al. (2009) No association between DGKH and bipolar disorder in a Scandinavian case-control sample. Psychiatric Genet 19: 269–272.
- 38. Espinosa F, Marks G, Heintz N, Joho RH (2004) Increase motor drive and sleep loss in mice lacking Kv3-type potassium channels. Genes, Brain and Behavior 3: 90–100.
- 39. Chan JR, Watkins TA, Cosgaya JM, Zhang C, Chen L, et al. (2004) NGF controls axonal receptivity to myelination by Schwann cells or oligodendrocytes. Neuron 43: 183–191.
- 40. Kim DY, Carey BW, Wang H, Ingano LAM, Binshtok AM, et al. (2007) BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biology 9: 755–764.
- 41. Roy K, Murtie JC, El-Khodor BF, Edgar N, Sardi SP, et al. (2007) Loss of erbB signaling in oligodendrocytes alters myelin and dopaminergic function, a potential mechanism for neuropsychiatric disorders. PNAS 104: 8131–8136.
- 42. van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, et al. (2004) Evidence of an association between the vasopressin V1b receptor gene (AVPR1B) and childhood-onset mood disorders. Mol Psychiatry 9: 287–292.
- 43. Wilson GM, Flibotte S, Chopra V, Melnyk BL, Honer WG, et al. (2006) DNA copy-number analysis in bipolar disorder and schizophrenia reveals aberrations in genes involved in glutamate signalling. Human Molecular Genetics 15: 743–749.
- 44. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, et al. (2005) Efficiency and power in genetic association studies. Nat Genet 37: 1217–23.
- 45. More T (1973) Axioms and theorems for a theory of arrays. IBM J Res Develop 17: 135–175.
- 46. Franksen OI (1994) Invariance under nesting - an aspect of array-based logic with relation to Grassmann and Peirce. Boston Stud Philos Sci 187: 303–335.
- 47. Marchini J, Howie S, Myes S, McVean G, Donnelly P (2007) A new multipoint method for genome-wide association studies via imputation of genotypes. Nat Genet 39: 906–913.
- 48. Howie BH, Donnelly P, Marchini J (2009) A flexible and accurate genotype imputation method for the next generation of genome-wide association studies. PloS Genetics 5: e1000529.


text:
485 modern guestrooms in green courtyard added options to meeting, business and travel. Free wifi internet access, room service and individual services are provided.
Luxury rooms in No.4 and No.9 building provide VIP individual items including swimming and welcome gifts on complimentary basis. Scenic view of garden is available in rooms.
For more information & reservation:8610 6232 2288-5606/5668
Business rooms with light color including the room type of single and standard room.
With fashion mixed color, the room is comfortable for business travel. The room types are including single and twin room.
With garden view, the twin room provides an elegance and comfortable stay.
The room type is twin room.
In the center of the garden, the room provides a quiet and comfortable stay.
The room types are including twin room and suite.
The deluxe rooms with modern furnishings provide an elegance and enjoyable stay.
The room types are including luxury single room, luxury suite and garden suite.


text:
Talk WiD Tech is a tech desk, a desk where we talk about all the latest technology. Here you can find all the technical stuff which matters to you.
Talk WiD Tech is a new technology channel which founded in May 2018. And with this platform we are trying to serve you the best Technology content in a simple way. We want to create a new technology world which has no boundaries of learning and where we can learn together. Here in Talk WiD Tech we provides you all the Tech news, reviews , features , Tricks, Entertainment and more and more tech stuff.
With Talk WiD Tech we are taking a fresh start with a New team. We know it would take some time to meet with your expectations but surely very soon we will and because it is a new tech journey so we want to start with quality and than we'll go for more quantity. And if you have any suggestions and feedback's for us , tap on the "Contact us" option and send us what kind of improvements you wants from us, and we promise that we will fix them as soon as we can.


text:
Free to Apply.
No Obligations to Accept.
No faxing required.
Online form.
Agree to lender's terms and money will be deposited to your account
Native American Payroll Loan "Arrowheadadvance Com Log In". ArrowHeadAdvance cash loans are a way to get your hands on the cash you need when you are essentially out of options. Are you really out of options though? Maybe you have another way to make ends meet, but you just feel like you are backed into a corner. If that's the case, you could avoid having to apply for a payday loan. You can get payday loans for really bad credit by using Arrowheadadvance Com Log In, and read reviews.
Arrowheadadvance Com Log In, Or else, then you have the choice of looking for that sort of loan. You should bear in mind, however, that this interest is not really going to be your friend. The payments for this sort of loan will probably be total as much as be much more than the things you borrowed. When you pay it back all at once, you're still planning to have paid excessive interest.
You may not care so much should you pay say $240 for the $200 loan. But let's say you refinance the financing a few times, and you end up paying $320 for the $200 loan. That's a major difference. Now let's claim that you truly sign up for a $200 loan with the installment payment agreement. You might pay a lot more than $320 on the lifetime of the loan, bottom line.
These loans look a bit more appealing as soon as the payments are spread out, but which can be deceiving when it comes to your current financial picture. You need to know how a loan will almost certainly impact your finances. Is applying with Arrow Head Advance Cash Loans actually the right move?
You may well be believing that you will find a better way at this time. It certainly would be nice, and you're going to have to make that decision. At the minimum, spend some time to reflect on the current position and what you're going to do. Don't stew within the matter, but instead resolve to check out the trouble from all of the angles.
Should you do that, you're more likely to see which you have other choices. You might not like exactly what the choices look like, with the circumstances. Yet tell the truth with yourself about whether or not another choices would create better off over time regarding your financial predicament.
Occasionally funds are just tight. This is among one of those occasions, but you know what is on the plate. There are a few financial emergencies which can be more challenging to find out than others. When you have some of those financial emergencies, then you already know you need to do need to make the ideal solution.
Create a list of your respective options. In case you have some time, provide some other thought as well as perhaps talk with someone as well. If you are able to create a much better solution than a cash advance, then that might be the best way to solve the problem. What's it planning to use to get out of this financial circumstances? Just how do you simultaneously improve your budget at the same time you discover an answer? Arrowheadadvance Com Log In
| Arrow HeadAdvance Com Address | ArrowHeadAdvance Com | Www.Arrow Head Advance.com | Www.Arrow Head Advance Com | ArrowHeadAdvance Phone Number |
Copyright © 2012- ArrowHeadAdvance.com. All Rights Reserved


text:
To provide you with a more responsive and personalized service, this site uses cookies. By clicking "Accept", you agree to our use of cookies. For more information on the ones we use and how to delete or block them please read our policy.
Read our cookie policy
The next step forward – redesigned cab and new unloading technology on Case IH Axial-Flow® combines for 2013
Case IH unveils new features on Axial-Flow® combines for 2013 / Cab revisions create the ultimate operator environment / New unloading auger technology improves trailer filling accuracyCase IH has...
Feb 25, 2013 - ALL - CASE IH - LATEST NEWS
(All Fields Required)
You must complete additional steps or remove assets to resume downloading.
IMPORTANT: Please note that any recipients of this Media Cart will be able to download its contents, regardless of the access rights any recipient may have. For example, if you have added restricted content ANY recipient of the Media Cart will be able to download its contents (regardless of whether they have access rights or not). Additionally, users may forward or share a Media Cart with other users, who would also be able to download the Media Cart's contents. Please add content to this Media Cart with caution.
Your Media Cart has been sent to:
You must enable cookies in your browser to use the Media Cart feature.
Thank you for getting in touch with us, we'll get back to you as soon as possible.
Some items have been removed from your Media Cart because they are no longer available or expired.


text:
Solar Innovations® offers a variety of finish options for our products. The color illustrations shown are as accurate as photography and printing processes allow. Since all computers, monitors, and internet browsers are calibrated to display color differently, we recommend you make the final color selection from a physical sample. The options on this page may vary, depending on your individual viewing settings. Please contact Solar Innovations® to receive a physical color sample. Custom options are available as well, but they may require extended lead times.
Stock Finishes*
Liquid Paint AAMA 2603, 2604*, 2605*, or Powder Coating AAMA 2604* or 2605*.
SI White
SI Bronze
Class 1 Clear Anodized*
Dark Bronze Anodized*
Designer Finishes*
Liquid Paint AAMA 2603, 2604*, 2605*, or Powder Coating AAMA 2604* or 2605*.
SI Natural Clay
SI Hartford Green
SI Sandstone
SI Black
*Please note the SI Standard finishes in AAMA 2604 & 2605, as well as the Anodized options, are available at an additional cost than the AAMA 2603.
Powder Coating Solids*
Powder Coating AAMA 2604 or 2605
Apollo White
Bone White
Fashion Gray
Colonial Gray
Military Blue
Antique Bronze
Hartford Green
Powder Coating Metallics*
Powder Coating AAMA 2604 or 2605
Cosmic Gray
Light Bronze
*Please Note: Powder Coating available depending upon color selection and volume.
Wood Veneering
Clear coat samples are finished with three coats of ICA clear sealer and are provided for reference only. Please note that veneer interiors are unfinished unless quoted otherwise.
White Oak
Southern Yellow Pine
Northern White Pine
Red Oak
Spanish Cedar
Western Red Cedar
Douglas Fir
White Maple
Faux Wood*
Solar Innovations® is proud to offer a variety of faux wood finishes for internal and external use. Color and species options beyond those shown below are available upon special request.
Acadia 1001
Acadia 1001
Douglas Fir
Knotty Pine
Oak Assi
Dark Walnut
National Walnut
Metal Cladding*
Lead Coated Copper
Stainless Steel – Satin
Stainless Steel – Mirror
*Please Note: Depending upon color selection, additional charges and longer lead times may apply. Color illustrations are as accurate as standard photography, and printing processes allow. Please make final finish selection from a physical sample; please contact Solar Innovations® to receive a physical sample. All product and finish options are subject to vendor availability. Solar Innovations® reserves the right to discontinue any option at any time without notice.
Addition options, including custom color match, are available.


text:
Jeanne-Louise is a social entrepreneur based in Pretoria. She tackles social issues through design thinking, inventing useful alternatives to current challenges people face in Pretoria.
She studied Information Design at the University of Pretoria, paving her way into the creative industries. In 2016 -2017, she and her team at Phlogiston Creative Industries re-ignited Molo Mollo, a nomadic cinema club based in the heart of Pretoria's CBD. Molo Mollo, roughly translated means "Hello Fire". It is a project that re-imagines decentralised spaces in the city.
With a pop-up silver screen and a great sound system, a popcorn machine and the help of a good team, Molo Mollo screens a variety of films on Wednesday nights from various locations in Pretoria.
Currently, Jeanne-Louise is experimenting with different methods of teaching and learning. How can technology compliment the way we learn and problem-solve in South Africa? How can design thinking improve a student's interest and sense of self at school and later in life? These are some of the questions that Jeanne-Louise is tackling with her new endeavour, Coin Projects. She is currently studying a tertiary teacher's diploma through UNISA.


text:
Harvard Health Blog
FDA approves weight-loss drug Contrave
Posted September 12, 2014, 1:40 pm Howard LeWine, M.D., Chief Medical Editor, Internet Publishing, Harvard Health Publications For the third time in two years, the FDA has approved a drug to help people lose weight. The new drug, Contrave, combines two generic drugs, naltrexone and bupropion. Naltrexone is used to help kick an addiction to alcohol or narcotics. Bupropion is used to treat depression and seasonal affective disorder. Many people also take bupropion to


text:
Britt Selected OVC Co-Male Field Athlete of the Week
Britt OVC's Best in the Triple Jump
Trenton Britt has been selected the Ohio Valley Conference Co-Male Athlete of the Week. Britt was credited with a first place finish in the triple jump with a mark of 47'9.25" (14.56 meters) at the 9th Ed Temple Classic. Britt also placed 13th overall in the long jump with a jump of 20'10.75".
Additionally, Britt is currently at the top of the OVC Best List in the triple jump with a season best of 48'06.00" a mark achieved at the MTSU Christmas Invitational.
Other Tigers ranked first on the OVC Best List, Worlie Johnson (55m), Nathaniel Moore, (400m) and Anes Koko (800m).


text:
Posted: 11 Jul 2011
Another win for Melandri
A fierce on-track battle between Italian rivals Marco Melandri and Max Biaggi was the order of the day at the Czech Republic round of the World Superbike Championship. Although they diced for the lead throughout the race, it was Melandri who emerged the well-deserved victor. It is his third win of the 2011 season.
Carlos Checa also showed determination throughout the race at Brno, challenging the two leaders for podium honours. However, he had to settle for third place at the chequered flag, as Melandri and Biaggi once again took first and second place finishes respectively.
All change for Biaggi and Melandri
In stark contrast to the first race results, Max Biaggi has won the second race at Brno from Marco Melandri.
The Italian duo once again fought tirelessly for the top spot throughout the race, while championship leader Carlos Checa again had to settle for a third place finish – reducing his points lead to 30 overall.


text:
Has your car broken down? Do you need to get back on the road? At Speedymech we stock a range of car batteries to help get your vehicle back on the road.
We sell and fit batteries for all makes and models of vehicles. We can test your vehicle to identify whether your vehicle's problem is with the battery or another issue such as charging or electrical faults. We aim to provide you with a cost-effective solution.
Does your car sound like a boy racer's when you accelerate? It could be a problem with your exhaust.
An underperforming exhaust can result in reduced efficiency of your vehicle in turn leading to an increase in fuel consumption and fuel costs. It can also lead to and cause other serious problems in your vehicle. At Speedymech Garage Services we can test, repair or replace car exhausts.
Regular maintenance, repairs and replacement of your vehicle greatly reduces the chances of breakdowns. Maintenance provides a much more cost-effective solution than car repairs or new cars.
At Speedymech Garage Services we can come to you whenever you need us. We can come to you for emergency, breakdown recovery and offer a free local collection and delivery service for regular maintenance.


text:
SAN FRANCISCO (MarketWatch) -- Medtronic Inc. MDT, +0.14% after Monday's closing bell said the Food and Drug Administration has approved its AneuRx AAAdvantage abdominal aortic aneurysm stent graft with Xcelerant delivery system. AneuRx AAAdvantage is a device to treat bulges in the aorta artery.
Medtronic: FDA approves new AneuRx AAAdvantage system
Quote References
+0.17 +0.14%


text:
Product Description
Duration: 5 Days
Course Content
ICND1 v2.0 includes major updates and aligns to an updated blueprint. Several topics have been moved from ICND2 into ICND1, while some topics, such as RIP and wireless, have been removed from this course. Course content has been adapted to Cisco IOS Software Release 15 and technically updated. All configuration commands are introduced through examples and supported with lab exercises. All labs are developed with new pod topology and newer networking gear.
Basic computer literacy , Basic PC operating system navigation skills, Basic Internet usage skill, Basic IP addressing knowledge
Who Should Attend
ICND 1 Part 1 is an essential training course for students preparing for the CCNA RS or CCENT certification.
- Students pursuing the CCNA RS certification should attend part 1 & 2 of ICND.
- Students pursuing the CCENT Certification need only attend part 1 of ICND.
- Individual seeking the CCENT Certification or CCNA Routing and Switching Certification
- Support Techinicians involved in the basic installation, operation, and verification of LAN networks
- Entry-level network engineers, network administrators, network support technicians, and help desk technicians
Course Objectives
Upon completing this course, the learner will be able to meet these overall objectives :
- Describe network fundamentals and build simple LANs
- Establish Internet connectivity
- Manage network device security
- Expand small to medium sized networks with WAN connectivity
- Describe IPv6 basics
Lokasi Training
IT Learning Center
Permata Kuningan bld 17th floor, Jl. Kuningan Mulia Kav. 9
HR. Rasuna Said, Jakarta Selatan – Indonesia
Hubungi kami untuk informasi lebih detail
Email : [email protected]
Phone/WA : 0811-1798-352
Email : [email protected]
Phone/WA : 0811 1798 353
Atau dapat mengisi form Inquiry & Information dengan mengklik tombol dibawah ini.


text:
History is important to us. It shows us where we were and how we have changed. Humanity has come a long way, and we have the pictures to prove it! There are some iconic pictures we probably have all seen in magazines, on TV, or in history books. The following collection of photos are rare and historic. So, let's take a trip into the past with these historical images!
1. A Zeppelin was seen flying over the pyramids in 1931. Before the Hindenburg crash, this was a popular type of airship.
I learned a few new things looking at these pictures – did you?


text:
Filed under: Time Warp, Bugatti, Chevrolet, Misc. Auto Shows, Ferrari, Motorcycles
Click on the image to view three classic Arlen Ness customs
Arlen Ness, a legend to the custom bike community, started out by painting customer bikes on the weekends as he worked to deliver furniture during the week to pay the bills. Gradually, his skills and reputation transformed his small company into the parts-selling juggernaut that it is today. Along the way, Ness has created quite a few one-off creations, many of which are now considered to be classics. Some of them, like the '57 Chevy knock-off "Ness-talgia", twin-engined and twin-supercharged "Ferrari-bike" (above) and Bugatti-inspired "Smooth-Ness" recall iconic automotive designs of years past. According to Ness, those three bikes represent some of his personal favorites, and each of them, along with many others, will be on display at an upcoming exhibit at the Motorcycle Hall of Fame in Pickerington, Ohio called Awesome-Ness. Interested in attending? The event will run from July 24 through the end of June 2009.
Gallery: Arlen Ness Motorcycles
[Source: Motorcycle Hall of Fame Museum]
Read | Permalink | Email this | Comments


text:
It's no secret I can't bear to organise a birthday party. A combo meal-deal of working full-time meeting a distinct lack of creative ideas means we usually end up a bowling alley or the park. Boring, I know, but one can't fake a good party.
Jo Power from Melbourne greeting card company and party blog Things by Bean provides fab tips to ensure your next birthday isn't a dump and run babysitting session – and the parents actually stick around for some fun too. And she has a few cracker ideas up her sleeve when it comes to inspiring your next party. No matter where it is.
Photo shoot fun – Everyone can let their hair down with a silly photo shoot. Pick a spot with good lighting (indoors or outdoors) and put together a backdrop of balloons or streamers. Near the backdrop, set up a small stable of props – feather boas, crazy sunglasses, masks, big fake flowers and hats are perfect. If you have an instant camera (Instax or Polaroid), encourage guests to take snaps with their phone and post them on Instagram with a hashtag just for your party (ie. #jamieturns8).
The mummy – It doesn't matter how old you are – wrapping someone in toilet paper is fun! This is perfect for birthday parties because the bigger the group, the better it is. Break into groups of 4-6 people and give each group a roll of toilet paper. Each group nominates one person to be The Mummy and starting at the same time, each group has three minutes to wrap the toilet paper around The Mummy – and I mean the entire roll! Whichever team makes the most creative mummy wins. Make sure you document this one, you won't stop laughing at photos of the finished Mummies!
Eat the donut – This deliciously fun game can be played by anyone who loves donuts! Which is just about everyone. For each person playing, thread a thick piece of string through the hole of a donut. Tie the ends of each string to a clothesline or tree so that the doughnut dangles in the air (keep the height of each player in mind). You can play this game with teams or individual players. For each round, a player from each team must eat the donut off the string without using their arms or hands and without the donut falling on the ground. Whoever finishes their donut first is the winner! But, really, everybody wins because everybody gets to eat donuts!
Pin the something on the something – With a little tweaking, this old-school game can be great fun for party guests of all ages. For the kids, do a classic Pin the Tail on the Donkey, positioning it lower on the wall so the little ones can reach it. For the adults, think of a pop culture icon of your generation that your guests will love and find a photo of it. Upload the photo to Rasterbator (a free online tool that enlarges and divides photos so you can print out big wall art at home) and tape it up on the wall at adult height. Next, create something funny to pin onto it! You could get guests to Pin the Scar on Harry Potter or Pin the Halo on Beyoncé.
Party bags are not just for the kids – Don't send your guests home empty-handed! Goodie bags are a great way to send a bit of the party home. When you're putting together goodie bags for your next kid's birthday party, do a batch of goodie bags for kids and a batch for adults. The kid's bags can be filled with the usual lollies and trinkets – they're always a hit. For the adult goodie bags, turn it up with beautiful dark chocolates, rum balls or soy candles set in elegant glass jars.
Head to www.thingsbybean.com to stock up on Things by Bean's bright and cheeky birthday cards and fuel party inspiration with creative DIY ideas and cake recipes. I can genuinely say they are better than mine. Which isn't that hard in reality.


text:
Fascism is the union of government with private business against the People.
"To The States, or any one of them, or to any city of The States: Resist much, Obey little; Once unquestioning obedience, at once fully enslaved; Once fully enslaved, no nation, state, city, ever afterward resumes its liberty." from "Caution" by Walt Whitman
"To The States, or any one of them, or to any city of The States: Resist much, Obey little; Once unquestioning obedience, at once fully enslaved; Once fully enslaved, no nation, state, city, ever afterward resumes its liberty." from "Caution" by Walt Whitman
Tuesday, July 8, 2014
Pattern of cyber-attacks against "leftist" populist news journals
2014-07-08 from "Common Dreams" [commondreams.org]:
I'm not paranoid. And I'm not a conspiracy theorist.
But sometimes the evidence just keeps piling up and makes you realize that 'they' really are out to get you.
We've been sabotaged.
Over the past year the Common Dreams website has been facing repeated malicious breaches and massive, coordinated Distributed Denial of Service (DDoS) attacks from unknown perpetrators. These attacks cause our servers to repeatedly overload and crash—often taking us many hours to get back on-line.
Eventually we get the website stabilized and all the pieces working again. And, for a couple months, all runs smoothly.
Until the next attacks begin…
Over time a clear pattern has emerged: they hit us when it hurts most.
Our non-profit media funding model is built much like National Public Radio's fundraising campaigns: several times a year set a realistic goal; be aggressive for a couple weeks until the goal is met and then leave people alone: no more fundraising until it's time for the next campaign.
We are now in the midst of our Mid-Year campaign. And, 'they' are back. We have been knocked offline repeatedly at the worst possible time for our fundraising.
Before last week, the last two extended attacks came during our Spring 2014 and Winter 2014 campaigns. And... we fell well short of our goals in both campaigns.
Why are we telling our readers about this only now?
We didn't want to encourage the perps. We didn't want to let them know they were succeeding in causing us real harm. We didn't want them to know we had no way to stop them.
But now we think we will soon have a defense against these attacks. Our website platform was built in 2007—light years ago for the internet—and has vulnerabilities that left us defenseless.
Over the next couple weeks we will be relaunching our website on a brand-new platform that will give us protection against the kind of attacks we have been facing.
But for now, we must make our Mid-Year goal. Falling short for a third consecutive campaign could be a fatal blow to us.
Tonight, we are still $32,000 shy of meeting our goal. Can you help us get there?
We can't do it without you!
Gratefully,[signed] Craig Brown for the whole Common Dreams team
P.S. Our online donations are processed by a very secure third party vendor which was not part of the DDoS attacks on our website. Your donations are safe, tax-deductible and deeply appreciated. If we are knocked offline when you try to donate, checks can be sent to: Common Dreams, PO Box 443, Portland, ME 04112 USA.
P.P.S. Our investigative news team is working on a series of articles on other ways Common Dreams and other progressive news sites are being actively sabotaged. Coming soon… stay tuned.
Subscribe to: Post Comments (Atom)


text:
Equity Incentive Plans (Tables)
|6 Months Ended
Jun. 30, 2019
|Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
|Schedule of Stock Option Activity
A summary of option activities under the 2005 Plan and 2017 Plan during the six months ended June 30, 2019 is as follows:
|Schedule of Stock-Based Compensation Expense Recorded in Condensed Consolidated Statements of Operations
Total stock-based compensation expense associated with the 2005 Plan, 2017 Plan and 2017 ESPP is recorded in the condensed consolidated statements of operations and was allocated as follows (in thousands):
- References
+ Details
No definition available.
- Definition
+ References
Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed.
+ Details
Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
- Definition
+ References
Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.
+ Details
Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef


text:
In a striking and impressive corner in Getsemani, two minutes away from Cartagena's Convention Center and a couple steps away from historic Downtown, is located Capellan de Getsemani, a boutique hotel Shabby Chic style, that highlights the city's history, with built-in fine details from exclusive designs that makes them pioneers of luxurious hotels.
The hotel offers an exclusive arquitecture, with fountains, with subtle illumination, vegetation and designs that offer the tranquility that their guests seek. The hotel has a terrace covered in crystal floors that turn into an amazing overlook, spa zones, pool and jacuzzi that were designed to enjoy a great traditional ceviche, and author and organic cocktails, that makes a perfect combination to share beautiful landscapes and sunsets in Cartagena.
With their exclusive services they fulfill every need that their guests have, 24 hours room service, airport transfer, local transport and a panoramic elevator that facilitates access to the hotel installations.
Capellan de Getsemani gives life to glamour, exclusivity, luxury and comfort.
Jetsemani LLC
United States
Excessive alcohol is harmful to health. It's prohibited to sell alcoholic beverages to minors.
In development of the provisions of Article 17 of Law 679 of 2001, tourists are warned that the exploitation and sexual abuse of minors in the country are penalized and administratively sanctioned, in accordance with the laws in force.


text:
Cry Wolf (Alpha and Omega Series #1)
I would love to give it a 4.... I did not love it as much as the Mercy books, but I still enjoyed it.The funny thing was that it was not Charles and Anna I liked the most. Sure they were ok, poor Anna all scarred from her horrible time in an evil pack, and Charles being a good little assassin. Together they tried to find a way to be together since she had lots to work through. But here it comes, when Bran showed up now and then I forgot all about these two. I was totally crushing on the Marrok in this book. And I demand he gets a series of his own and a good woman so that he is happy and so that she is happy, cos like it is now it is just sad.So what have we learnt then, I love Bran, oh right about the book. Well it was a nice little mystery about who is going around killing in the mountains. I liked Asil, the old wolf who longs for death and there was a nice backstory.And yes do read the short story before reading this one.I will continue this series of course, Briggs rocks and Bran, now look there I go again, major crush alert.


text:
Wassailing and quizzes - five things to do in and around Weston this weekend
PUBLISHED: 17:00 19 January 2018
A centuries-old West Country tradition will be celebrated this weekend as people prepare to wake the apple trees and scare off ghosts.
Wassailing events will take place around the area over the next few weeks in the hopes of securing another successful harvest.
– A fundraising quiz in aid of the Birnbeck Regeneration Trust will be held at the Weston Workingmen's Club in Orchard Street on Friday.
It starts at 7.30pm and tickets can be booked by contacting Rose at firstname.lastname@example.com or by calling 07597 807008.
– Author MC Slack will be reading his book, Babu The Ninja, at Weston Library, in Walliscote Grove Road, on Saturday from 1.30-2.30pm.
Activities will be running for children aged four to eight. Register for free at www.eventbrite.co.uk
– Jacob's Choir will host a fundraising day for Cots For Tots at Emmanuel Church, in Oxford Street, on Saturday.
The event will run from 2-5pm and will include a game of bingo.
– Dust away the winter cobwebs and look forward to spring with naturalist Chris Sperring.
Chris will lead a birdbox-making session at Big Worle Hub, in Clovelly Road, on Saturday from 11am-2pm.
– It is wassailing season and villages across Somerset will be chasing away the bad spirits.
The tradition will see people banging saucepans with wooden spoons through the villages to wake the apple trees after a long, cold winter.
Head over to Hutton on Saturday at 6pm for its ceremony.
People are asked to meet at Wood View in Moorcroft Road before continuing on to Walnut Barn in Church Lane. Tickets, priced £4-8, are available from Hutton Stores in Main Road.
If that was not enough, The Mendip Rotary Club will host a wassail at Rich's Cider Farm, in Mill House in Highbridge, on Saturday at 7pm.
The Skimmity Hitchers and Bob Darch Music will provide some entertainment and tickets, priced £7.50, are available on 01278 783651.
If you are out and about this weekend then why not send up your photos. Simply upload them to www.iwitness24.co.uk


text:
Minimum Stair Width Chair Lift Chair Design Stair Lift
This image gallery named as Minimum Stair Width Chair Lift Chair Design Stair Lift might be ideal solution for your decoration. As the author has insert this image into Chair Lift For Stairs Medicare post section, would ease you to find the perfect match of you decor desire.
The physical exercise ball is of use for a fitness center when it has to do with your own everyday lifestyle, you'll be able to turn it to a minimum stair width chair lift chair design stair lift. This concept even becomes extremely popular in the latest past even though some still oppose this chair. In general, a more 5-feet tall man needs a ball using a 45cm diameter. And also the greatest drill ball is only 75cm in diameter that may suit a 6-feet tall individual. But, it's not easy to chance upon a Pilates ball using an 85cm diameter to get a 6'8′" man or woman. Meanwhile, you will require a bigger dimensions of the chunk to generate a cozy at least one size bigger.
The most essential things you should search for before buying a minimum stair width chair lift chair design stair lift may be the dimension. Before you browse a catalogue of kitchen chairs, you need to know for the appropriate dimensions for the kitchen. To do it, you need to be familiar with measurement of your kitchen as well as the dining table table you use. The next aspect to think about is how many chairs that you would like to put on the dining table table. This way it is possible to figure out the magnitude of this market chair you need to decide, if you want to get or even chairs without elbows.
Gaming would make the item designers enticed to generate a minimum stair width chair lift chair design stair lift. If you are a significant gamer take this action seriously, you'll require an effective however useful chair to support your actions. The clear presence of a chair for gaming helps you in the event that you may select the proper one. The best design and style of the particular chair will mostly get those features we will describe. Employing the off-ice chair isn't enough to function as compared with the . Thus, you can have to spend the excess money however, also the outcome is well worth it .
Fourth, use a chair which can likewise be put back. Maybe not just the height of the chair has to be adjusted however, additionally the peak of the backrest. It really is advisable for you to select a chair whose backrest can be corrected depending on your shoulder elevation. To steer clear of soreness or pain on the shoulders and spine, the chair you employ needs to have a back that's the very same elevation as your own shoulder. The final, decide on minimum stair width chair lift chair design stair lift with headrests. Chairs who have further head rests can actually make your body posture better when sitting down. The reason is, this backrest causes your neck and head parallel to the ear lobe. The can make you stay away from neck muscle aches.
Even the maturation of art, sciencetechnology, accompanied by the development of varied civic movements straight affected the minimum stair width chair lift chair design stair lift in particular, and therefore are considered being a brand new generation of art artwork. This produces the contemporary chairs do not merely grow to be the tool to support seating, nevertheless in addition they act as things which represent your own characteristics, tastes, fashions, and maybe lessons. However, once selecting modern-day chairs on your house, stability must also be noticed, between your chair and the interior design that you just apply, therefore it will generate a beautiful appearance. In addition you need to correct the size of this which you opt for. They will get your area feel more crowded. In the event you opt for the most suitable layout, measurement, and color of one's modern chairs, the friends who visit your home will really experience comfortable staying in the area to get quite a long time. Even the unique and innovative layout of one's new chairs will mean nothing if they don't provide a comfortable seating experience for your requirements and your guests.
Deciding on a minimum stair width chair lift chair design stair lift is a must for encouraging the productivity of their personnel. They ought to feel comfortable when working in order that they could deliver their very best potentials. At an identical time, they should have the ability to protect against from your back injury as a result of hours of sitting on the chair at work. The chair provided available on the market includes diverse models and functions. Steelcase could possibly offer them with an Leap off ice chair that may function as selection. The jump chair can provide perfect support for different body sizes and shapes. The capabilities accessible may help individuals find out the great things about this chair.
Gallery for Chair Lift For Stairs Medicare
Medicare Lift Chair Form Founder Stair Design Ideas
Stair Lift Electric Stair Stair Elevator Stair Lift Option
Motorized Stair Lift Medicare Founder Stair Design Ideas
Chair Lifts For Stairs Covered By Medicare Chairs Home
Best Chair Lift For Stairs Latest Door Stair Design
Arlington Heights Stair Lifts And Ramps Chair Lift Stairs
Best Attic Ladder Pull Down Attic Pull Down Stairs
Wheelchair Assistance Stair Lift Chairs
Wheelchair Assistance Stair Lift
Wheelchair Assistance Medicare Stair Lift
Stair Chair Lift Medicare Bariatric Stairlifts Available
Minimum Stair Width Chair Lift Chair Design Stair Lift
Great Ideas Stair Lift Chairs Covered Medicare Founder
Chair Lift Stairs In Many Different Models Founder Stair
Lift Chairs For Elderly Medicare Chairs Home
Slight Idea Of Chair Lift For Stairs Medicare Founder
Leave The Details To The Experts For Chair Lift For Stairs
Let39s Talk About Stair Chair Lift Medicare Founder Stair
Are Chair Lifts Covered By Medicare Chairs Home
Acorn Stair Lift Instruction Manual Chairs Home
Acorn Stairlifts Careers Authentic Bruno Stairlifts
Chair Lifts For Stairs Covered By Medicare Senior Stair
Chairs How To Choose Stair Chair Lift Stair Chair Lift
Modern Does Medicare Cover Stair Lifts Safety Founder
50 Incredible Photographs Of Chair Stairs Lift Covered By
Chair Lift For Stairs Canada Chairs Home Decorating
Straight Chair Lift Stairs Medicare Founder Stair Design
Choosing Handicap Stair Lift Home Decor
Outdoor Chair Lift For Stairs Best Chair Lift For Stairs
Chair Design Stair Chair Lift Prices Medicare
Stair Chair Lift Medicare Wheelchair Assistance Adastra
Stair Lift Chairs Covered Medicare Chair Ideas
Marvelous Handrail Height Ideal Stair Railing Height In
Chair Lift For Stairs Medicare Home Design Ideas
Chair Lifts For Stairs Covered By Medicare
Chair Lifts For Elderly Chairs Home Decorating Ideas


text: A freshman forward on Gallaudet University's men's soccer team, Chad was named to the All-North Eastern Athletic Conference second team. He earned NEAC Offensive Player of the Week honors in September and ranks in several NCAA Division III stats: 21st in shots on goal per game (2.38), 28th in goals per game (0.88), 30th in points per game (2.0) and 37th in points. Chad ended the season second in the NEAC in points (32), goals (14) and shots (69). The former Palisades High star had four multi-goal games, including a hat trick versus Valley Forge to go with one assist for a career-best seven-point outing. He scored in nine of the 16 games he played in and led the Bison in every major offensive category. To nominate your favorite Palisadian for Athlete of the Week, email email@example.com.


text:
- Interactive Touch Screen Operation
- Full Analysis and Guidance Information Provided
- Inbuilt Software in 14 Languages
- The Tanita MC780 Plus is the flagship model
Call us to arrange a free demo on 0845 340 4042
|Weighing Capacity
|Weighing Increment
|5 Years
|Call Us - Best Available
Inquire about "Tanita MC980 Plus"
Additional Info
The Tanita MC980 Multi Frequency Segmental Body Composition Monitor is the ultimate tool in providing fast in-depth information for truly personalised health or fitness professional consultations. Incorporating the very latest multi-frequency BIA technology with increased data display and the flexibility of in-built Microsoft® Windows® real time operating system software, this monitor has been meticulously designed for fast, convenient and accurate consulting.
The MC 980 provides a full body composition analysis in less than 30 seconds and has an easy to follow colour interactive touch screen display. The in-built software runs in 14 languages and the detailed consultation sheet shows the results, such as segmental analysis, basal metabolic rate and phase angle in an easy-to-read format.
Simplicity at your fingertips
Integrated Windows® for Maximum Flexibility
For the first time a fully featured Windows® real time operating system has been incorporated allowing maximum flexibility in downloading data, uploading updates and connecting printers and other accessories for data output.
Inbuilt Software in 14 Languages
All of the in-built software is displayed in 14 languages (English,German, Spanish, Turkish, French, Italian, Dutch, Polish, Danish, Norwegian, Swedish, Finnish, Greek and Russian) making the administrator set up and usability simple, fast and stress free.
Interactive Touch Screen Operation
The intelligent extra large touch screen display will effortlessly guide the client through the measurement process through the extra large interactive touch screen display. The user can register their profile data for future use or just take a single measurement.
Full Analysis and Guidance Information Provided
Tanita has incorporated the latest Advanced BIA technology utilising 6 critical frequencies to take a body composition measurement in under 30 seconds.
With the ultra low platform design and high weight capacity of 300kg, the MC980 is suitable even for heavier patients. Once the measurement has been taken, the user can easily see in-depth information, screen by screen, of their results. Key measurements have guidance information boxes to help explain more intricate data.
Registered Users Can Access Previous Measurements
If the user has registered their profile, their body composition analysis will be stored. A full history of each measurement can be shown to highlight their progress helping maintain motivation and understanding of how their body is changing over time.
Detailed Consultation Sheet
A full consultation sheet can then be printed on any Microsoft® Windows® compatible printer for further discussion or future reference. The printer can be connected directly to the MC980 for ease of use.
Database Management Facility
The database management system allows full analysis and manipulation of data suitable for research projects, client data management or programme effectiveness. Data can easily be downloaded to any compatible PC via a simple USB connection.
Modular and Portable
The MC980 construction is modular making transportation very convenient. Due to its clever design, it can be set up in under 5 minutes without any special equipment or tools. The in-built wheels allow for ease of movement from location to location.


text:
Exchange an item
If you wish to change your shoes for another pair you need to pay the postage to return the shoes to us, however we will pay for the postage for the new pair.
Right to cancel
Our return policy means that you as a customer in accordance with the Distance and home sales Act have a right to cancel your contract within 14 days. The deadline for returns starts the day you as a customer receives the shoes. During these 14 days you can cancel the contract by leaving or sending us a message that you have changed your mind. According to the Distance and home sales Act we have an obligation to refund the amount within 30 days after we have received the goods. The return policy only applies if the shoes, including the box, are returned in essentially unchanged condition.
Please note that the fee for postage, 12 EUR, will be charged at the time of your refund.
Wrap the package well to avoid any damage during shipping. For example, use a plastic bag as packaging. Don't put the return shipping label directly on the box. Ensure you obtain a receipt which contains the package ID from the parcel distribution centre, it makes it easier to track the return if needed. If the parcel is lost during the return delivery you as a customer are responsible for the payment. When you return your shoes we also want you to return the original box and care instructions.
Please use the checklist below to double check that everything is included in order for the return to be approved by HEELOW.
Checklist for returns:
- Shoes
- Original box
- Care instructions
Please send the shoes to:
Heelow AB
Tvärhandsgränd 5
16766 Bromma
You pay for the return postage yourself.
Please contact our customer services on firstname.lastname@example.com and tell us why you want to return the item. Please state your order number and invoice number. Customer services will help you further with your claim.
If it is possible to repair the shoes we recommend that you go to a cobbler and then submit the receipt to us.
If the shoes cannot be repaired we will email you a special return shipping label to you so you do not need to pay for postage.
When we have received the shoes and approved the claim you will be refunded the amount you paid for the shoes.