text:
(1/142) The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development.
The embryonic expression of COUP-TFII, an orphan nuclear receptor, suggests that it may participate in mesenchymal-epithelial interactions required for organogenesis. Targeted deletion of the COUP-TFII gene results in embryonic lethality with defects in angiogenesis and heart development. COUP-TFII mutants are defective in remodeling the primitive capillary plexus into large and small microcapillaries. In the COUP-TFII mutant heart, the atria and sinus venosus fail to develop past the primitive tube stage. Reciprocal interactions between the endothelium and the mesenchyme in the vascular system and heart are essential for normal development of these systems. In fact, the expression of Angiopoietin-1, a proangiogenic soluble factor thought to mediate the mesenchymal-endothelial interactions during heart development and vascular remodeling, is down-regulated in COUP-TFII mutants. This down-regulation suggests that COUP-TFII may be required for bidirectional signaling between the endothelial and mesenchymal compartments essential for proper angiogenesis and heart development. (+info)
(2/142) Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.
Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling. (+info)
(3/142) Functional study of the E276Q mutant hepatocyte nuclear factor-4alpha found in type 1 maturity-onset diabetes of the young: impaired synergy with chicken ovalbumin upstream promoter transcription factor II on the hepatocyte nuclear factor-1 promoter.
Seven mutations in the hepatocyte nuclear factor (HNF)-4alpha gene have been shown to correlate with type 1 maturity-onset diabetes of the young (MODY 1), a monogenic form of type 2 diabetes. Up to now, only the functional properties of two MODY 1 HNF-4alpha mutants, Q268X and V393I, have been investigated to address how the mutations in the HNF-4alpha gene, found by genetic studies, can give rise to impaired activities of mutated HNF-4alpha proteins and can cause this disease. The E276Q mutation results in a nonconservative substitution occurring in the HNF-4alpha E domain, which is involved in dimerization and transactivation activities as well as in protein-protein interactions with other transcription factors or coactivators. Using the mutated human HNF-4alpha2, we have found that, in the absence of chicken ovalbumin upstream promoter transcription factor II (COUP TFII), the E276Q substitution does not significantly affect the dimerization and transactivating activities of HNF-4alpha, at least on the promoters studied herein. On the other hand, in the presence of COUP TFII, the substitution impairs the enhancement of HNF-4-mediated activation of HNF-1 promoter. The impaired synergy between COUP TFII and HNF-4 on the HNF-1 promoter results from an alteration of their interaction. HNF-1 expression plays a crucial role in transactivation of insulin promoter and of numerous genes coding for enzymes involved in glucose homeostasis. Therefore, its downregulation resulting from the E276Q mutation in HNF-4alpha gene most probably impairs the function of pancreatic beta-cells. (+info)
(4/142) Dorsal and ventral retinal territories defined by retinoic acid synthesis, break-down and nuclear receptor expression.
Determination of the dorso-ventral dimension of the vertebrate retina is known to involve retinoic acid (RA), in that high RA activates expression of a ventral retinaldehyde dehydrogenase and low RA of a dorsal dehydrogenase. Here we show that in the early eye vesicle of the mouse embryo, expression of the dorsal dehydrogenase is preceded by, and transiently overlaps with, the RA-degrading oxidase CYP26. Subsequently in the embryonic retina, CYP26 forms a narrow horizontal boundary between the dorsal and ventral dehydrogenases, creating a trough between very high ventral and moderately high dorsal RA levels. Most of the RA receptors are expressed uniformly throughout the retina except for the RA-sensitive RARbeta, which is down-regulated in the CYP26 stripe. The orphan receptor COUP-TFII, which modulates RA responses, colocalizes with the dorsal dehydrogenase. The organization of the embryonic vertebrate retina into dorsal and ventral territories divided by a horizontal boundary has parallels to the division of the Drosophila eye disc into dorsal, equatorial and ventral zones, indicating that the similarities in eye morphogenesis extend beyond single molecules to topographical patterns. (+info)
(5/142) Chicken ovalbumin upstream promoter-transcription factor II, a new partner of the glucose response element of the L-type pyruvate kinase gene, acts as an inhibitor of the glucose response.
Transcription of the L-type pyruvate kinase (L-PK) gene is induced by glucose in the presence of insulin and repressed by glucagon via cyclic AMP. The DNA regulatory sequence responsible for mediating glucose and cyclic AMP responses, called glucose response element (GlRE), consists of two degenerated E boxes spaced by 5 base pairs and is able to bind basic helix-loop-helix/leucine zipper proteins, in particular the upstream stimulatory factors (USFs). From ex vivo and in vivo experiments, it appears that USFs are required for correct response of the L-PK gene to glucose, but their expression and binding activity are not known to be regulated by glucose. A genetic screen in yeast has allowed us to identify a novel transcriptional factor binding to the GlRE, i.e. the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII). Binding of COUP-TFII to the GlRE was confirmed by electrophoretic mobility shift assays, and COUP-TFII-containing complexes were detectable in liver nuclear extracts. Neither abundance nor binding activity of COUP-TFII appeared to be significantly regulated by diets. In footprinting experiments, two COUP-TFII-binding sites overlapping the E boxes were detected. Overexpression of COUP-TFII abrogated the USF-dependent transactivation of an artificial GlRE-dependent promoter in COS cells and the glucose responsiveness of the L-PK promoter in hepatocytes in primary culture. In addition, a mutated GlRE with increased affinity for USF and very low affinity for COUP-TFII conferred a dramatically decreased glucose responsiveness on the L-PK promoter in hepatocytes in primary culture by increasing activity of the reporter gene in low glucose condition. We propose that COUP-TFII could be a negative regulatory component of the glucose sensor complex assembled on the GlRE of the L-PK gene and most likely of other glucose-responsive genes as well. (+info)
(6/142) Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene.
The c-mos proto-oncogene is specifically expressed in the male and female germ cells of the mouse and other vertebrates. We previously identified a 15-base pair sequence element (B2) as the binding site of a candidate repressor of c-mos transcription in somatic cells. In the present study, we used the yeast one-hybrid system to isolate HeLa cell cDNAs encoding proteins that specifically bound to the c-mos B2 element. Nucleotide sequencing identified several of the clones isolated in this screen as the orphan nuclear receptors COUP-TFI and COUP-TFII. A COUP-TF-binding site was then identified within the B2 sequence. Complexes formed between purified COUP-TFs and the c-mos B2 probe comigrated in electrophoretic mobility shift assays with those formed using whole nuclear extracts of NIH 3T3 or HeLa cells. Moreover, the complexes formed with NIH 3T3 nuclear extracts and B2 probe were supershifted with antibody against COUP-TF, identifying COUP-TF as the candidate repressor previously detected in these somatic cell extracts. Substitution of a consensus COUP-TF-binding site for the c-mos negative regulatory element suppressed expression from the c-mos promoter in transfected somatic cells, demonstrating the functional activity of COUP-TF as a repressor of c-mos transcription. (+info)
(7/142) HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7alpha-hydroxylase gene (CYP7A1).
The gene for cholesterol 7alpha-hydroxylase (CYP7A1) contains a sequence at nt -149 to -118 that was found to play a large role in determining the overall transcriptional activity and regulation of the promoter. Hepatocyte nuclear factor 4 (HNF4) and chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) synergistically activate transcription of the CYP7A1 promoter. Transactivation of CYP7A1 by HNF4 in the human hepatoma cell line, HepG2, was enhanced by cotransfection with COUP-TFII or the basal transcription element binding protein (BTEB). HNF4 prepared from rat liver nuclear extracts bound to oligomers homologous to the nt -146 to -134 sequences in electrophoretic mobility shift assays (EMSA), which corresponded to a conserved region containing a direct repeat of hormone response elements spaced by one nucleotide (DR1). The sequences surrounding this DR1 were found to be essential for the HNF4 transactivation. In vitro-translated COUP-TFII was found to bind the adjacent sequences from nt -139 to -128 (DR0), but COUP-TFII interacted with this region at a much lower affinity than to the COUP-TFII-site at nt -72 to -57 (DR4). Mutations at nt -139 to -128 or nt -72 to -57 reduced the COUP-TFII and HNF4 synergy; however, these COUP-TFII-binding sequences were not absolutely required for the cooperative effect of HNF4 and COUP-TFII on transactivation. These results indicated that the observed transactivation was the result of protein/protein interactions facilitated by the juxtaposition of the binding elements. (+info)
(8/142) ARP1 in Golgi organisation and attachment of manchette microtubules to the nucleus during mammalian spermatogenesis.
Actin related protein of vertebrate, Arp1, is a major component of the dynactin complex. To characterise and localise Arp1 during mammalian spermatogenesis, polyclonal antibodies were raised against a human recombinant Arp1. Anti-Arp1 antibodies were used for western-immunoblotting, indirect immunofluorescence and immunoelectron microscopy. In round spermatids, Arp1 was detected at the centrosome and at the Golgi apparatus. In elongated spermatids, Arp1 was predominantly found along microtubules of the manchette and at their site of attachment to the nuclear envelope. In maturing spermatids, Arp1 was still present in the pericentriolar material, but in testicular spermatozoa it was not detectable. These various localisations of Arp1 and their changes during spermatid differentiation suggest that the dynactin complex in association with dynein might contribute to several activities: the functional organisation of the centrosome and of the Golgi apparatus and the shaping of the nucleus by manchette microtubules. (+info)


text:
Share and discuss videos, images, stories, and more that involve sex between women and men with a bisexual subtext that's both arousing and taboo to straight or mostly-straight men.
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Where bisexual redditors exchange pictures and videos of their nude bodies for karma; showing it off in a comfortable environment without pressure.
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Bibros aims to build a brotherhood around shared interests, promote self acceptance, and bring people together both online and in the real world.
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subset: commoncrawl


text:
View Masters Programs in Conservation 2019 in Ravenna in Italy
Master-level studies involve specialized study in a field of research or an area of professional practice. Earning a master's degree demonstrates a higher level of mastery of the subject. Earning a master's degree can take anywhere from a year to three or four years. Before you can graduate, you usually must write and defend a thesis, a long paper that is the culmination of your specialized research.
Conservation studies programs typically look at the interaction between natural resources, energy, technology, population, cultural values and societal institutions. Courses are sometimes interdisciplinary and may explore topics such as: conservation and resources, conservation biology, biodiversity and conservation and wildlife conservation.
Request Information Master's Degrees in Conservation in Ravenna in Italy 2019
1 Results in Conservation, Ravenna Filter
Master in Science for the Conservation - Restoration of Cultural Heritage
University of Bologna
The course is aimed at the education and training of Conservation Scientist, a scientist with knowledge on chemistry, physics, biology, geology and informatics applied to cultural heritage and further knowledge in conservation (ethics, history, cultural values, historical technologies, past and present conservation technologies and practice, specific scientific aspects, etc.).


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text:
Smoker Biker Girls - Biker Dating - United States
Browse profiles of Female users here at Biker Next that are tagged with Smoker. Dating other members that have like minded interests is an ideal way to find things to do once you are dating. Signup for a Totally Free Account to Go out Today!
- 58
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- 54
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It's not about the...
It's not about the destination, it's about the...
Easy going, love to ride. Not sure what to write here so, if you would like to ask me a question... I look to see who I'm talking to so no pic no talk.
- 55
Smart independent with a...
Smart independent with a heart of gold
Smart, successful independent woman with a huge heart when it comes to those I care about. I don't put up with any bs, I speak my mind, but my heart is a good one. Looking for a man who can appreciate a strong woman and knows how to treat a lady right. No BS or egos apply. I am ambitious and is...
- 56
Single mother of three...
Single mother of three grown men proud grandmother...
Fun, love to laugh, Riding feeds my soul. Don't put up with perverts bad attitudes or alcoholics. I'm looking to meet a friend that can possibly turn into more if you're a nice guy and don't have any intentions on bringing me down then hit me up. Must love yourself I have total confidence in...
- 49
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- 51
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text:
Fiona Bruce's fear on Roadshow gig
The Face
The queen of the autocue and the permanently arch-eyebrowed newsreader Fiona Bruce is to take over the reigns of the Antiques Roadshow this Sunday after Michael Aspel left last year on the BBC show's 30th anniversary.
The 44-year-old mother of two, who before turning to current affairs was a blue-haired punk during her student days, when she was in three rock bands, says presenting the Roadshow has been a career dream.
"All human life is there," she says. "It was always my secret ambition, but I never told anyone. I couldn't imagine why they would give it to me." Bruce, who will continue to present the BBC Ten O'Clock News bulletin on Fridays, will face some tough challenges on the programme. Not only does she…


text:
It is a rare scenario where long-term interest rates suddenly fall below short-term interest rates.Real Estateread more
It was the third trigger of the recession indicator in less than two weeks.Bondsread more
Overstock CEO Partick Byrne has resigned from the e-commerce company after making comments about his role in the "deep state."Technologyread more
Automakers are trying to deal with President Trump's efforts to roll back Obama-era fuel efficiency rules.Autosread more
Mark Zuckerberg has been on a selling spree in August and has unloaded $526 million worth of stock this year.Technologyread more
Palantir CEO Alex Karp said billionaire investor Peter Thiel is right to question Google's decision to work in China, while abandoning military contracts in the US.Technologyread more
These are the stocks posting the largest moves midday.Market Insiderread more
U.S. manufacturer growth slowed to the lowest level in almost 10 years in August, the latest sign that the trade war may be exacerbating the economic slowdown.Marketsread more
L Brands shares fell by as much as 12% at one point, touching $17.61 — a price not seen since December 2009.Retailread more
"The president is not backing down," says CNBC's Jim Cramer, referring to Trump's repeated calls for the Fed to cut rates while talking tough on China.Economyread more
The market rebound this week hasn't convinced the strategist predicting a "Lehman-like" sell-off that the risk is completely off the table.Marketsread more
Spain's Constitutional Court on Thursday ordered the suspension of Monday's session of the regional Catalan parliament, throwing into doubt its plans to declare unilateral independence from Spain.
The speaker of the Catalan parliament, Carme Forcadell, accused the Madrid government of using the courts to deal with political problems and said the regional assembly would not be censored. But she said parliamentary leaders had not yet decided whether to defy the central court and go ahead with the session.
The suspension order further aggravated one of the biggest crises to hit Spain since the establishment of democracy on the 1975 death of General Francisco Franco. But Spanish markets rose on perceptions the order might ward off, at least for now, an outright independence declaration.
Spanish Prime Mariano Rajoy called on Catalan leader Carles Puigdemont to drop independence plans or risk "greater evils".
Secessionist Catalan politicians have pledged to unilaterally declare independence at Monday's session after Sunday's referendum, banned by Madrid and marked by violent scenes where Spanish police sought to hinder voting.
The constitutional court said it had agreed to consider a legal challenge filed by the anti-secessionist Catalan Socialist Party.
Spanish shares and bonds, hit by the political turmoil in Catalonia, strengthened after the news of the court's decision. The main IBEX stock index rose 2.5 percent and the yield on Spain's 10-year bond fell.
Spain's Economy Minister Luis de Guindos told Reuters in an interview the turmoil was damaging Catalonia.
"This is generating uncertainty that is paralyzing all investment projects in Catalonia. I'm convinced that, right now, not one international or national investor will take part in a new investment project until this is cleared up," he said.
Some of Catalonia's biggest businesses began taking steps to transfer their registered headquarters to other cities in Spain.
The board of Spain's fifth-largest bank, Sabadell, decided at an extraordinary meeting on Thursday to move the bank's registered head office to Alicante, the bank said.
The board of Caixabank, Spain's third-largest lender, will meet on Friday to study a possible transfer of its legal base away from Catalonia, a source familiar with the situation said.
The Spanish government will approve a decree on Friday making it easier for companies to transfer their legal base out of Catalonia, two sources said, a move that could deal a serious blow to the region's finances as it considers independence.
The new decree is tailor-made for Caixabank, sources familiar with the matter said, as it would make it possible for the bank to change its legal and tax base without having to hold a shareholders' meeting.
Opinion polls conducted before the vote suggest a minority of around 40 percent of residents in Catalonia backed independence. But a majority wanted a referendum to be held, and the violent police crackdown angered Catalans across the divide.
In an interview with Spanish news agency EFE, Prime Minister Rajoy said the solution to the Catalan crisis was a prompt return to legality and "a statement as soon as possible that there will not be a unilateral declaration of independence, because that will also avoid greater evils."
He did not elaborate but ruling party lawmakers say Rajoy, a conservative who has taken a hard line on Catalan independence, is considering the unprecedented step of dissolving the Catalan parliament and triggering regional elections.
Catalan officials released preliminary referendum results showing 90 percent support in favour of breaking away. But turnout was only about 43 percent as Catalans who favour remaining part of Spain mainly boycotted the ballot and many polling stations were closed.
Puigdemont said, in response to a question from the German Bild daily, he was not afraid of being arrested.
"And I'm not surprised any more about what the Spanish government is doing. My arrest is also possible, which would be a barbaric step."
Neither the Spanish government nor the judiciary has threatened to arrest Puigdemont, though Madrid accuses him of breaking the law by ignoring a Constitutional Court ruling forbidding the referendum.
On Wednesday, in a televised address, Puigdemont renewed his call for mediation in the dispute but said the results of the referendum would have to be applied.
Rajoy has ruled out international mediation as a format for resolving the future of Catalonia, offering instead all-party Spanish political talks to find a solution, on condition independence is taken off the table.
Barcelona football club joined captain Andres Iniesta in calling for talks between the Spanish government and Catalan leaders to resolve the crisis.
"We will go as far as people want it. But without the use of force," Puigdemont told Bild. "I am sure that Spain will not be able to ignore the will of so many people."


text:
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text:
Hello Gurus,
This morning, pressing the Home key did not work.
Now, it's working.
- 1
Hello Gurus,
This morning, pressing the Home key did not work.
Now, it's working.
Hi. Sometimes, I have great difficulty scrolling to the top of a list. For instance, when I search all notes for a certain string, scan the long list of search returns by scrolling down the list, find the desired note, then cancel my search, by pressing the X on the search bar, EN will understandably leave me on the last note i was viewing. The problem starts when I drag the vertical scroll control to the top of the list. When I drag the v-scroll control to the top of the list, and release the right mouse button, EN will bounce the vertical scroll control back down the list. If I drag the v-control back up to the top again, EN will bounce it back down again... and again... and again. Have others noticed this issue? Workarounds? Has EN identified this issue as a problem? Thanks.
I, too, am seeing high cpu usage by en with version 188.8.131.5234.
Be nice if windows incorporated enhancements which...
- allow users to set, right in task mgr, max cpu possible for an app
- forced an app to report the reason for cpu usage above a certain level... so we would know, for instance, that en is indexing the db, etc.
Be nice if en would throttle-back non-critical, long running, high cpu operations, when sensing keyboard and mouse activity.
7 hours ago, CalS said:
If you are talking across platforms, PC to IOS for example, yes there are some inconsistencies. Font size changes and tables lacking perspective for two.
No, not cross platform, just web EN to local installed EN... on the same machine.
By the way, this failure to maintain line-spacing sometimes happens when I paste text from one EN to another EN.
You'd think that EN would be able to preserve line-spacing in EN-to-EN copy / paste situations.
3 hours ago, CalS said:
Your are welcome.
Yes, you can have multiple accounts stored on the same computer. Just go to File - Add another user to sign in to additional accounts. A data base, a .EXB file, will be created for each account. You should get an icon in your task bar for each account open to facilitate switching between them.
Cal, suppose I add, as you described, my work en user to my personal account, and can then access both my personal en, and my work en, from same en instance...
If everyone that accesses my work en uses the same login that i use, will they have access to my personal en info?
Thanks Cal. A related question: Am I able to have two different en accounts, installed locally, on my computer? I think my company's en is the free en version.
2 hours ago, gazumped said:
Hi. Evernote is not a word-processor and does not support line spacing as such. Pasting from another app will often bring hidden style codes that display a particular spacing, but if you remove the formatting from the note it will often revert back to standard single spacing. The only way to preserve layout would be to attach the original app output file - a DOCX or PDF file - so you can edit as necessary. If you don't see the content of the document as part of your note, you could copy and paste the 'de-styled' text into the note purely for reference and (maybe) search index purposes...
Thanks Gazumped. EN could do a better job of preserving original line-spacing/formatting. They might start with a new, very targeted, format-preserving preference enhancement: Preserve Original Line Spacing.
Hi. When I paste text into EN, with Ctrl-V, often the space between lines is greatly increased.
Sometimes, if I paste the text with Ctrl-Shift-V, the white space between lines is decreased--sometimes too much.
How can I paste text into EN and keep the original line spacing?
I access my company's web-based EN and my personal local-installed EN on the same machine.
Can I bring my company's EN into my personal EN, without any risk that employees of my company would be able to access my personal EN?
Probably not necessary to mention but... my company's EN, and my personal EN, have different logins.
Hi. I access (mostly from my personal computer) a premium personal Evernote account and I access (from the web) a shared work Evernote account.
Is there a way for me to setup my personal Evernote, so that my work Evernote is accessible from my personal Evernote?
I want to add that everyone at work logs into the work Evernote with the same credentials. So, I don't think the situation, which someone mentioned, where they access work EN from personal EN and vise-versa, would work for me.
When I select a few lines of text, and then select to Increase Indent or Decrease Indent, the selected text will move in-or-out by a certain amount.
How can I increase or decrease the amount that selected text is moved in-or-out?
It seems that every month, one or more very well-financed company will report that their customers' data was hacked. Some in the security business say that if a company is a sufficiently attractive target, it's not a question of "will you be hacked?" but "when will you be successfully hacked?"
EN is certainly a very attractive hacking target.
I am feeling less and less comfortable with my personal documents being stored on en.
At one point, I was encrypting all sensitive documents.
However, that process is time-consuming and eliminates one of the major en benefits: quick, comprehensive searches.
It seems that en needs to offer another level of protection--a level of protection which would require customers to optionally supply a encryption key to un-encrypt their data; a level of protection such that a hacker would need to un-encrypt each customer's account individually.
What do others think on this topic?
Here's a quote from a OneNote review: "OneNote takes this further, and instantly OCRs any text in images you add." Does Evernote OCR all images? When I scan a document, my scanning software seems to create an unsearchable image of the document, in a pdf file. When that document is stored in Evernote I still cannot search and find words in the document from Evernote. Any suggestions/thoughts/ideas appreciated. Thanks.
What do others think about en providing an enhancement which would allow customers, with a verified U.S. address, to optionally encrypt any note with 128/256 bit encryption?
What about en providing an account option which allows encryption at the expense of indexing? I guess searching would be on titles and tags?
Already done!
1.) Individual text information can already be encrypted.
2.) For more security, put your notes into a non-synchronized local Evernote notebook. Never hits the cloud.
3.) For higher security, use TrueCrypt to protect your Evernote notes.
The speed and ease of one-button, one-step sending to en is important to me. Most of my sensitive documents arrive in pdf format. Besides, a key en feature is its ubiquity across platforms--I don't want to have documents stored on my pc when they are needed on my android phone. As another poster suggested, I think that en should provide an encrypt configuration switch so that all data is encrypted--metadata (tags, titles, etc.) is left unencrypted and searchable.
You should be aware that Evernote does NOT encrypt either the Note or its attachments. Evernote's current policy is one of "buyer beware" and they push the security onto the user. If your documents contain sensitive info you may want to encrypt prior to upload to Evernote.
Seems like a huge omission. After all, for many, the main attraction of en would be a central/cloud location to store all personal documents. Some of the documents stored with en are going to be very personal. If someone hacks into en servers--some would say it's not if, but when somebody hacks into en servers--all those personal documents will be available to the hacker... Without the added effort of having to unencrypt each customer's en account? Am I missing something?
Since this has already been discussed *at great length* on the board, already, please search the board on security and/or encryption. In a nutshell, EN cannot index encrypted notes.
What about en providing an account option which allows encryption at the expense of indexing? I guess searching would be on titles and tags?
You should be aware that Evernote does NOT encrypt either the Note or its attachments. Evernote's current policy is one of "buyer beware" and they push the security onto the user. If your documents contain sensitive info you may want to encrypt prior to upload to Evernote.
Seems like a huge omission. After all, for many, the main attraction of en would be a central/cloud location to store all personal documents. Some of the documents stored with en are going to be very personal. If someone hacks into en servers--some would say it's not if, but when somebody hacks into en servers--all those personal documents will be available to the hacker... Without the added effort of having to unencrypt each customer's en account? Am I missing something?
I'm thinking that it would be nice to have the en icon on all pdf (both browser plug-in and stand-alone adobe) windows. That way, I've got a one-button send to en. True?
anyone have links to discussions/descriptions about automatically sending financial documents to en?
i am finding that in many instances, when i want to send en a document, the document is displayed in a pdf window and that window does not have the en icon. so, i then have to take a screen-shot, send the capture to a file, then find the file and have en pickup the file. is there an easier way?
Encryption kills Evernote's ability to index information.
Video on Evernote encryption
Overview of Evernote encryption
https://support.ever...9 3&docID=23768
Type of Evernote encryption
https://support.ever...0 4&docID=23797
Lots of additional encryption information on this forum - just use the search feature to get up to speed.
>>Encryption kills Evernote's ability to index information.<<
But I would be more than happy to to forgo indexing capability of these documents to have encrypting at the "entire note level." In this instance, I am moving product support documents that contain screen images. The documents are currently encrypted at my skydrive. It's a real wrinkle in my 'move to en plans' that these documents cannot be encrypted. Any suggestions? Thanks.
hi. i just started using en. it looks like only text within a note may be encrypted. why not allow encryption at the note level? also, it appears that documents which contain images may not be encrypted. why that limitation?


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Date: Nov 02, 2018
Date: Oct 04, 2018
Date: Oct 17, 2017
After months of rumors, Samsung has finally announced this week its new Flex foldable display. The development is a major win for Samsung and differentiates the brand strongly from rivals like Apple and Huawei.
Samsung Claims the Vast Majority of 5G Smartphones Shipped in Q2 2019
Aug 08, 2019
The Global Sales Of Bluetooth Headsets Will Surpass Half A Billion By 2024
Aug 07, 2019
The Galaxy Fold is Back: Bold, Beautiful, Delicate?
Jul 25, 2019


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to the guys who like to pee outside whenever they get a chance, even there's a toilet nearby.. would you thinks it more than just enjoying being a man rather a fetish of some kind?
Have an opinion?
Admit it, you would do it too if you could. Don't lie now...
You cannot undo this action. The opinion owner is going to be notified and earn 7 XPER points.


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New York City Considers Lifting Hostel Ban to Lure More Tourists
City council bill pushes to legalize budget hotels after nearly decadelong ban
New York City could legalize hostels under a bill set to be introduced this week in the city council, the second attempt to reauthorize the budget hotels after a state law made them illegal.
Councilman Mark Gjonaj and Councilwoman Margaret Chin are co-sponsors of the bill, which would give hostels their own department and classification in the city.
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Drone and Phone - Malaysian Adventure
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Golden Hearts Award 2018
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Anchor Stone has been denied permission to expand its quarry in Owasso, Oklahoma.
The long-established quarry to the east of Owasso is attempting to expand again after previously being denied in 2003.
At its Thursday, Oct 8, meeting, the Owasso Economic Development Authority unanimously voted against a resolution city staff had proposed. Owasso City Council voted 4-0 in favor of supporting the resolution at its Tuesday, Oct 6, meeting.
"We cannot mine north or south to a certain point. It made sense to us and residents to connect the dots and grow the quarries together and not outward," said David Charney, chairman of Tulsa County Board of Adjustment.
City staff is opposed to the expansion due to the potential impact on residents' homes and quality of life.


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Subscribe to our FREE email newsletter and download free character development worksheets! A few ground rules heading in imagine a bespectacled man in an ill-fitting brown suit standing over me and dictating in a nasally voice: These answers are mine and mine alone, and I do not presume to speak for the industry at large or for WD. Nothing you read here is meant to be direction on how to embark, sustain or engage in a publishing career, nor should you assume there is any specific path to success based upon my responses. There are lots of ways to skin a thunder lizard. That last part is me, not the guy in the suit. So let us begin to see what you can learn when you … Ask an Agent Anything! Query Queries Dear Agent: But I could say the same thing about all the junk mail I receive. How much time do you really spend looking at each query—as in, average seconds per query letter?
Older Women Dating Younger Men: Doomed from the Start or Happily Ever After in Cougarville
Whether you are on a date or just talking on a phone with your girlfriend, silence will always be awkward. If you suddenly run out of things to say to her, you need to have a list of great backup questions in your mind that will keep the conversation going for hours. Some are really interesting and funny! Luckily, I am going to share with you a selection of the best things to ask and what to talk about with a girl.
This also allows you to know how wild or daring she really is.
Good questions to ask Here is my ridiculously long list of good questions to ask. Use them to get a conversation going or as a fun way to pass the time with friends or loved ones.
What kind of movies do you like? What are your favorite television shows? How much television do you watch? What kind of music do you like? How often do you listen to music? What type of music do you dislike the most? What was the last book you read and what was it about? What kinds of books do you like to read? Would you rather read a book, magazine, or newspaper?
How often to you read? What are your favorite topics of conversation?
30 Interview Questions You Can't Ask and 30 Legal Alternatives
Email Date nights for established couples can feel boring and stale if you talk about the same old topics all the time. So, here is a list of — yes, — questions that you can choose from to ask each other on your next dinner out. Advertising Use only two to three questions per date night, and really talk about the answers in depth.
They range across various domains, including romance, intimacy, family, career, and many others.
As an agent of more than five years with the Irene Goodman Agency, I am oftentimes approached at writing retreats, conferences, children's birthday parties, nail salons, shooting ranges and quinceañeras, and asked a variety of questions about my take on the inner workings of the publishing industry.
I have some super skinny friends who are considered really hot and always get hit on and then there are celebs who are super skinny, like Olivia Wilde and Megan Fox she supposedly has a 23 inch waist! Oh boy… touchy subject. I knew that sooner or later this question would come up and I would have to answer it. And, like everything else, I will answer it honestly without sugar-coating. To start things off, I can tell you that one of the things that guys will talk about is who we think is a hot chick.
However, women are constantly dieting and exercising to make their bodies look ideal for men and to be healthy too, of course. There was a study I read in college about body weight and attractiveness in women. Then, hundreds of women looked at these same pictures and rated how they believed men would rate the picture. What they found was that men prefer a woman that is pounds heavier than what the women believed to be the ideal weight that men want.
This study and others can be found in The Evolution of Desire by David M Buss Now I am not saying go cancel your gym membership and eat a tub of ice cream on the couch. Weight means your entire body weight — muscle, organs, fat, water, etc. Being fit is sexy. Fit means that you have a low body fat percentage for women, having a body fat percentage in the lower 20s is good.
Frequently Asked Questions about the Transcontinental Railroad
April 18, at Recovery involves much more than simply stopping the sexual acting out. Addicts almost always also struggle with lying, anger, selfishness, other addictive escaping behaviors like video games , and a lack of empathy for those they have harmed. It sounds like your fiance is not truly in recovery.
Anyway, the questions these dating sites ask are helpful when trying to find a date, and when you're thinking of starting a long-term relationship. They bring up the questions you don't think of.
Jim June 13, Marni I am sorry if I have taken to much space in your blog? Mae and I had a soulmate love affair! We had a couple drinks to celebrate then I carried Mae to bed. We made love and fell asleep in each others arms! I got up dressed went home jumped in the shower my wife joined me I carried her to bed and made love to her on my birthday in the morning! Jim June 10, Part 5 The reason it worked for Mae and I was the 38 years between us didnt bother us and since my wife was busy with work and allowed me to be oncall for Mae it was great.
Mae loved that from the first time I made love to her I would call her and thank her for a great time.
40 First Date Questions That are Foolproof
Generalities[ edit ] The Pauline epistles contain multiple condemnations of various forms of extramarital sex. Throughout history, most theologians have argued that any and all forms of premarital sex are immoral. An historical example is the medieval English monastic, John Baconthorpe.
Fornication is generally consensual sexual intercourse between two people not married to each other. When one of the partners to consensual sexual intercourse is a married person, it may be described as adultery.. For many people, the term carries an overtone of moral or religious disapproval, but the significance of sexual acts to which the term is applied varies between religions, societies.
I discovered this job vacancy in the Careers section of your website. When I saw the job description and responsibilities, it looked like a great fit for my background and skillset. What about this job interests you? The first thing that caught my eye when I saw this position was that it was [name of company], and the opportunity was located in [name of the city where the job is located].
I love the idea of helping [insert who the customers are] [insert what the customers do]. I think my proactive style would fit in really well — especially with this particular position — and I know I could start delivering results from Day 1. Do you know anyone else who works for [insert name of company here]? No I do not. Why are you looking for a new job? What I really like about the [insert name of job] role at [insert name of company] is that it is an international company with operations in 5 different countries.
21 First Date Questions
Email With a decades-long career in television, including his own show, Steve Harvey has conquered the media world. But during his rocket-like shot to the top, Harvey had his share of relationships and gained a lot of experience with women. Now he's turning this experience into sage advice for the fairer sex. One of those that stood out most was the lifestyle of a famous and well-regarded celebrity, whose name I'm just going to go ahead and keep to myself.
But this much I will tell you: I mean this man was surrounded by gorgeous women.
Good get to know you questions are unbelievably helpful when starting a new relationship from scratch because as we all know: Getting to know someone can be a little nerve-wracking. But these handy questions to ask to get to know someone can make it significantly easier for both of you.. Whether you're hanging out with a crush one-on-one for the first time, grabbing a drink with a new.
This is a virtual museum in cyberspace. Many are too delicate to handle. The restored and enlarged digital images presented here are often much easier to see than the original! Due to the ravages of age and technical factors, each image has typically required extensive restoration and modification using digital tools to eliminate defects and achieve what we believe is the most esthetic and historically accurate rendition of each picture.
Skillfully performing such magical transformations by digital image restoration requires considerable subjective judgment, artistry, originality , and creativity, as well as technology. Clarke, the famous science fiction writer once remarked that "Any sufficiently advanced technology is indistinguishable from magic. For example, it is often feasible to improve color and contrast, modify brightness, remove stains, and recreate missing or damaged portions. We want you to be aware that the images on this website consequently are not the "exact" copies which many image archives prefer, and consequently caution researchers to compare original images when appropriate.
10 Questions to Ask Before Getting Married
September 21, In every job interview, the goal is to obtain important information while building a friendly rapport with the candidate. But some questions are just a little too friendly. Protect yourself and your company from legal trouble and embarrassment by avoiding the wrong questions while still getting to the root of the concern behind the question. Read on for 30 ways to turn litigious questions into insightful, legal alternatives.
Want to seduce a girl with words? Use these 20 dirty questions to ask a girl over text and you can make her do all the sexy, dirty talking for you!
Got a crush on a guy you know? Whoever he is — you probably want to know more about him. So with that in mind, here are some great questions to get to know him: You get to marry one fictional character — who is it? In your mind, what are your 3 biggest weaknesses? You only get 3 words to describe yourself — what are they? Which is better to listen to — your heart or your brain? Do you consider yourself a spiritual person?


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The convertible is a companion to infant in their growing years. zealand pine wood, it all round protection ity. Though the rounded moldings panels giv..
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Slefuitor Girafa Evidentiere Syslite
Handmade of zealand pine. Position adjustable mattress platform. Jpma certified. Meets all asand cpsc safety standards. Manufacturer
Mini folding mattress has arched headboard styling generally found on convertible s. position adjustable posture board allows
Seat made of beech ply. Solid hardwood legs. Bird style. Chair. Armrest carrying handle color. Headrest distressed frame wood wood con.
Davincis regency drawer changer is the accompaniment to the regency in crib. a raised molding pattern on drawer fronts with
Pop color, playful style to nursery or playroom with the . Sized for books, buddies baskets of toys. bookshelf will help
Layering on trend accents atop a silhouette, the in convertible from is. The ends are with horizontal grooves for a modern
The in convertible with mattress bassinet system starts as a bassinet on wheels converted into a sized . modern, eco amicable
Composed of metal. Clean feel. Accomodates trundle unit only. Does not contain any chemicals. Standard . Color golden brown
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