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Spivey Club in Jonesboro, GA
8381 Members Drive; Jonesboro, GA 30236
Key Facts
- Style:
- Year Built: 2015
- Status: Active
- Elementary School: Arnold
- Middle School: M.D. Roberts
- High School: Jonesboro
- Beds Total:
- Upper Bedrooms: 1
- Baths Full: 3
- Baths Half: 1
- Main Full Baths: 2
- Main Half Baths: 1
- Master Bath Features: Double Vanity,Separate Tub/Shower,Soaking Tub,Vaulted Ceilings
- Upper Full Baths: 1
Kitchen & Dinning
- Dining Room Desc: Seats 12+,Separate Dining Room
- Kitchen Features: Breakfast Bar, Cabinets Stain, Kitchen Island, Pantry, Pantry Walk-In, View to Family Room
Exterior & Lot Features
- Private Yard
- Rear Stairs
- Complex/Building Access:
View All Amenities & Details...
Directions: From I-75 S, take Exit #228 and turn right on Hwy 138. Turn left on Speer Rd. and travel 1 mile. Turn right onto Walt Stephens Rd. The Spivey Club is 1.5 miles down on the right.
The information on this map was derived from a digital database. KNOWAtlanta cannot accept any responsibility for errors, omissions, or positional accuracy. There are no warranties, expressed or implied, accompanying this product. However, notification of any errors will be appreciated.
Contact KNOWAtlanta Real Estate Services
Listing Provided Courtesy Of: Keller Williams Realty ATL PartListings on this website come from the FMLS IDX Compilation and may be held by brokerage firms other than the owner of this website. The listing brokerage is identified in any listing details. Information is deemed reliable but is not guaranteed. © 2019 FMLS.
For issues regarding this website (and/or listing search engine, as applicable) please contact KNOWAtlanta - 770-650-1102
Listing information last updated on December 31, 1969, 7:00 pm


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6 9020 Young Road
Chilliwack, British Columbia
Welcome to the Corner Nook Cafe! Well established, turn-key, busy 28 seat restaurant, great staff & perfect opportunity to run your own business. All equipment included, 3 years remaining on the current lease w/5 year renewal option. Great home cooking, open for breakfast & lunch, clean & ready to go for the next owner! Great exposure on Young Road & new downtown core area expansion is sure to bring in even more business. Catering also a possibility to expand & grow revenue. Call today to arrange your viewing. (id:34603)
6352 165 Street
Surrey, British Columbia
Your search stops here w/room for the whole family in a fabulous location! At 4,000 sq ft., this 4 bed 3.5 bath home & 2 bed basement suite w/separate access has everything you need & more.With a welcoming foyer w/reception area, den & laundry room on main, formal dining & living room w/gas fireplace, huge eat-in kitchen w/gas range, tons of cabinetry, island which leads to the cozy family room w/gas fireplace. 4 bedrooms up, complete w/huge master, walk in closet & ensuite. 2 bedrooms share a Jack & Jill bathroom w/the 4th bedroom having an ensuite & balcony! Looking for a mortage helper or in-law suite? Gorgeous & newly renovated, this suite is amazing. White kitchen w/granite, gas range, spa like bathroom, laundry room, nook area, ample storage & 2 bedrooms! Check out the video tour! (id:34603)
52901 Parkrose Wynd
Rosedale, British Columbia
Executive living in sought after Rose Garden Estates. This impressive 5,892 sq ft home on 1/2 acre has WOW factor! Sweeping staircase, double height great room w/tons of windows, PRIVATE yard, pool, hot tub, fully fenced yard & stunning curb appeal. You will love the beautiful gourmet kitchen which leads to your dining room perfect for family holiday gatherings. The main floor rounds out with a master bedroom retreat w/ 2 walk-in closets & ensuite, huge laundry/mud room, his & her offices, powder room & hand scraped engineered hardwood floors. 2nd master up w/2 more bedrooms, flex & family room. The basement offers a media room, in-law or nanny suite (full kitchen!), separate access & laundry. Enjoy the peaceful setting & mountain views with this exquisite home. Check out the video tour! (id:34603)
7329 Marble Hill Road
Chilliwack, British Columbia
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- One Day at a Time Season 3 Episode 12
One Day at a Time Season 3 Episode 12
After putting Alex in a difficult position, Schneider gets tough love from Penelope. Dr. B consults Lydia's bouquet list for "non-iversary" gift ideas.
Views: 4
Serie: One Day at a Time
Episode Title: Drinking and Driving
Air Date: 2019-02-08
Year: 2019
Heer & Meester
A television series about a charming, voluntary private detective who chases criminals and in the process tries to find himself.
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Cult drama series about a group of aspiring young lawyers sharing a shabby house in London, charting their careers and personal lives.
The Mosley family keeps the secrets and dark history of a town located on the outskirts of New Orleans that is also a landing patch for the world's darkest manifestations…
Not Going Out
Lee is a childish northerner who lives in a fancy penthouse apartment in London who goes through a variety of jobs such as a janitor and ice cream man as…
Halt and Catch Fire
Set in the early 1980s, and about a fictional visionary, an engineer and a prodigy whose innovations confronts the corporate behemoths of the time. Their personal and professional partnership will…
Knight Fight
Welcome to the toughest, most violent armored combat competition in the world today. "Knight Fight" steps inside the world of the full-contact Armored Combat League — often referred to as…
Real Vikings
The history of the Vikings is explored by "Vikings" star Clive Standen, who joins experts in Europe to learn how the Vikings successfully invaded England and France.
Mexico: Earth's Festival of Life
The diverse peoples, wildlife, landscape and culture of Mexico are explored by focusing on three distinct worlds, great mountain ranges, tropical forests and scorching deserts.
100 Code
New York, USA. Stockholm, Sweden. Over the past twelve months young, blonde, blue-eyed women have been found dead in a meadow where Asphodel flowers grow. New York Detective Tommy Conley…
They got weed. They got powers.
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How to Deal With Competition For a Girl You Like [3 Steps]
This is probably due to the number of dating sites and dating apps Tired of Tinder? Seven Free Alternative Dating Apps Now that Tinder is charging for its services, it might be time to turn to one of the many other dating apps available. Which will you try? Read More available, which makes it much easier to find your potential happy ever after. Not every guy you meet online will be a player. Many very nice guys are just painfully shy when meeting new people.
Exactly How to Know If a Guy Likes You FOR SURE
If this is a guy you just started seeing… Over the course of the last decade and a half, texting has increasingly become a constant part of waking life. He might be focused on something and have his phone off. So just to get that out of the way: That is to say, you say NO to guys who are not heading in the direction you want to go and YES to the one who is?
Love the article. Indeed very helpful and it cleared out my questions about why the guy I'm dating went away. My mistake was doing the deed on the first date for having to really like the guy .
Older Married Women October 30, […] and talk to the objective girl. Adult dating sites can very often be and fast route to locate women looking for sex with internet dating is. All the alpha-posturing in the week it took place. Tania September 2, Its arduous to find knowledgeable people on this subject, however you sound like you know what youre speaking about! Thanks Lakshmi August 15, I agree with your advice. These were the exact mistakes I did in all my previous relationships which of course was a total disaster.
Let me tell you all my story. There was always this empty void which could only be filled by a relationship and I only realized this later in my life. Just when I had given up all hopes I came across this dating site I was little skeptical about dating sites long story short I found a perfect guy and next month 20th is our wedding day. Anyway cut a long story short, started chatting to this guy on Tinder,we are both in music so we understand the unsociable hours and the pressure that comes with it.
Anyway basically has been texting everyday, and get on really really well have a great sense of humour and banter between us that other people who are not working in music would not necessarily understand?
Ask a Guy: Why Did He Suddenly Stop Texting Me
Reviewed By Adriana , June 1, If you're new here, you may want to get my discreet newsletter to learn how to make him sexually obsessed with you and only you. Click here to get it. As a woman, making a guy jealous is one of the most powerful tools you have at your disposal!
There is no exact science that will tell you if a guy likes you back or not. However, there are many signs guys display when they are interested that can help you .
Well, then here you go! If you want to read about bragging stories of all those Western guys who get laid a hundred times per day, then you came to the wrong place. There are tons of blog posts like that out there. Dating is not the same for foreign women and men! You might ask yourself why is that? A lot of Japanese women want a guy that tells them several times a day how much he loves them. For some reason maybe through the consumption of too many Hollywood movies Japanese women think that foreign men are like that!
Japanese men seem to expect certain things from a woman. Things that they fear a foreign woman would not agree to do e. Another problem is that many of the Japanese men seem to be afraid of their English ability and thus fail to approach a foreign woman. Most foreign men on the other hand, have no issues approaching a Japanese woman in English — or even in broken Japanese.
These are just a few theories by friends, co-workers and myself. Dating in Japan as a foreign man: As a result, dating in Japan is usually quite easy for men.
Original TV Shows, Reality TV Shows
Share I would really appreciate some godly advice! At the beginning of the school year, I admitted to my friends that I had a crush on a guy. My friends ended up telling his friends, so he knew that I liked him. Then one of my now former friends told me that he texted her and said he liked her.
Sunnystategal May 31, Maybe you haven't ran across that because you're a guy. I've joined two dating services and on both it was the same thing. The guy didn't even give his real name and it was a scam to try and get money from you.
I had an older brother and sister 12 and 15 years my senior respectively, parents who were happy together, and my aunt and cousins lived one street over. I had a lot of attention growing up being the baby and all, but my main source of affection came from my Dad. To define our relationship like that would misconstrue it; we were simpatico.
Our father-daughter relationship was more like a typical father-son relationship. My mom hated seafood so we would often go get fish together and make fun of people at work, school, etc. My dad is tremendously funny and a phenomenal story teller.
From Casual Dating to Serious Relationship
Email Women all around the world agree that being in a relationship can bring a lot of delight and excitement into your life. There are many fish in the sea and the options are endless. For those ladies already in a relationship, you may wonder every once in a while whether you made the right choice by being with your significant other.
Is it time to rethink your options? To put your mind at ease, here are a few signs that you are in fact dating a great guy who you should never let go. He loves you for your dorky, awkward self Source:
This Guy Won't Stop Trolling His Neighborhood With Fake Posters, And People Can't Stop Laughing.
No problem unless and until bottoms done get confused and hypocritical at some times.. For a top, a bottom who begs and deliberately asks to abuse him both physically and verbally, is nothing short of a whore.. Infact many bottom guys loves themselves to be called as a whore.. A top also enjoys it , and it gets over then and there.. Both top and bottom enjoyed and got what they wanted.. I have seen such threads in this forum itself..
Bottoms just need to be clear in what they want.. If they demand respect then dont beg and demand for abuses..
How to stop choosing dangerous men Online
Yet again the EastEnders siren finds herself in a relationship with a man who, it seems, she'd be mad to trust with her shopping list, let alone her emotions. This week it's revealed that her latest liaison, charming firefighter Tom, has a guilty secret – he's married. Every time Sharon chooses a man, she's been rewarded with either cruelty or deceit.
The woman who lurches from one bad relationship to another isn't just the stuff of soaps. Maybe it's our best friend, our sister – or perhaps it's a problem we have ourselves.
Apr 20, · He's hoping you'll eventually just stop asking so he doesn't have to be the bad guy (makes no sense). An excuse once in a while can, of course, be legit, but if it happens more often than not, it's probably not.
Never feel ashamed about an age gap so small. Im 27 and i just met a guy who is 25 and i must tell you this guy treats me with respect and im like woww. Really , i just wan t to take it slow before i go into a relationship with him. But another thing is how he and his family feel about my tribe. Ive never been lucky with a man from his tribe because i dont speak their language.
Koalabutts Im 18 and my boyfriend is 15 turning 16 in a couple months and i always felt really awkward about the age difference since i usually date older guys. Noona Yes im in this 7 months relationship now. Im 28 years old and he is 20 years old turning 21 this april… I havent told my parents about this but my mun found about it through facebook and send me a pm that I should stop seeing him because he still a student and I should be looking for someone that I could settle down with.
Im scared since I dont know what will happened in th future , i mean he is still young. He still in the stage of doing exciting stuff and here i am preferring the laid back things to do.. Cutie So my crush is 3 days younger than me, help? And tell me how to get his gf to break up with him… mingming 3 years younger than you and you think that is a big deal? If you want to talk about older and younger think bigger like a 20 year age gap otherwise, it is a non story Gabby Boutte I am about to date a guy who is is about three years younger than me and at the moment, I feel like such a cougar.
Anytime I show him to my friends they tell me how young he looks compared to me, and it breaks my heart.


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text: anonymous wrote : I have a scenario where I MDB triggers a JCA adaptor to activate. During the activation process a session bean (local interface) is looked up to do some work. And who triggers the MDB? I mean who (and when) sends the message to the queue on which the MDB is listening? Can you post a snippet of the MDB showing where exactly the session bean is looked up? Is it part of onMessage()? View the original post : http://www.jboss.com/index.html?module=bb&op=viewtopic&p=4198298#4198298 Reply to the post : http://www.jboss.com/index.html?module=bb&op=posting&mode=reply&p=4198298


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Keyword Researcher is designed to search the Autocomplete databases of Google, YouTube, and even Amazon.com. That's a lot of keyword sources! As you probably know, if you're building an authority site, or if you would like to become a dominant player in your niche, then starting with a large database of keywords (that your customers are actually typing in) is a powerful marketing tool.
I will use the tool to pull in a lot of keywords related to a theme and group them into relevant topics. These topics will either become their own content page or will be combined with other topics to create a page. KeywordTool.io is similar to other tools out there such as Uber Suggest, which I've used for a long time, but it tends to produce more keywords and it provides search volume for the keywords.
"This is the only keyword research tool that I recommend. The ideas, inspiration, and content longtails you will get for your niche topic are going to result in you producing a page of content that is more than going to pay for this tool. And as they are Google's database then we KNOW that these terms are being searched by a decent volume of peeps every month. It's a goldmine dudes."
Great Top 10 keyword research tools list. Thank you for posting Robbie! I really appreciated the feedback from the experts. There are a definitely a few tools here worthy of taking note of. I have also been using DYNO Mapper (http://www.dynomapper.com) as a keyword research tool. DYNO Mapper is a visual sitemap generator that delivers keywords on all pages of any site. The user simply inputs any existing URL into the system and it will scan thousands of pages.
I've bought and used just about everything under the sun.. Swissmade marketings product.. MS ..stealth jw analyzer.. Ilovegooglepage1 the list goes on. I used LTP platinum. The one I use is kw blaze. I bought it in 2012 and still goes to this day with Skype support is vgood if there's any update issues. It has kw competirveness.. Moz rank ..fb likes.. A researcher.. And more quite powerful yet is free of mo.thly fees.
Settings. This tiny gear icon on the right upper corner is where you can ask support for "Help", toggle on or off the help icons; manage "User Accounts" (you need to enter your Google AdWords credentials when the software is run for the first time plus your Moz API details too, which are free to get since LTP uses a both AdWords and Moz's data); set the "Data Fetching Speed"; and check the "Show Runtime Error" and "Show Debug Panel" in the "Debug" section (which can be very helpful when there's something wrong with the tool or with your Google AdWords account).
I came across Longtail Pro this morning, downloaded the trial version and was about to buy the $97 program…seems like a good buy. But the more research I've done today, it seems the KC score is an absolute must for anyone who is serious about making money with niche sites. I hate to spend the bucks, but hate even more leaving money and possibly niche site success. Any advice?
Long Tail Pro helps to assess the strength of your competition and put you ahead of your competitors. It would help you to rank higher than your competitors. When it fetches the keywords for you, it filters it and delivers the relevant ones after filtering them and making them relevant to your domain. This way it would help place your business and your website ahead of its competitors.
1) Google Keyword Planner: This tools is fantastic because it can help me to identify long tail keywords for my niche. It is official Google's tool and it has the recent trends and keyword variations. For example you may think that this keyword is great "buy ipad air in liverpool" but Google may suggest "iPad air sale Liverpool". Yes, not often it is accurate but when I'm using it alongside the other tools – I can get clear idea.
If only it were that easy – right? I'll be the first to admit – it's not always that easy. I've created lots and lots of these types of sites over the past few years – and only a handful of them worked out. It can be a very hit or miss thing. But I do have one site in particular that I would like to highlight for you. It happens to be the very first niche website that I ever created! Why highlight this specific site? Because my very first attempt at a niche site happens to still earn more than enough money each month to pay for the expenses associated with Long Tail Pro! Check out the screenshot below from my Adsense account which shows stats for just this one site for exactly one year previous from the day that I am writing this post.
Use the Keyword Planner to flag any terms on your list that have way too little (or way too much) search volume, and don't help you maintain a healthy mix like we talked about above. But before you delete anything, check out their trend history and projections in Google Trends. You can see whether, say, some low-volume terms might actually be something you should invest in now -- and reap the benefits for later.
I think people's aresenal of keyword research tools are mostly the same: 1) You need a tool to examine search volume, most likely Google Keyword Planner 2) A tool to help you generate more keyword ideas. Tools that work with the search engines' autosuggestions are very popular such as KeywordTool.io and Ubersuggest 3) Then people might add a tool broaden the depth of their data, maybe including something like Google Trends or Moz's Keyword Difficulty tool.
However, KWFinder has a couple of areas where Longtail Pro outshines it. Firstly, I like the fact LTP provides you with a suggested keyword competitiveness to target (as described above). More significantly, I don't like the way that KWFinder restricts your number of keyword suggestions if you choose their cheaper pricing tier – it feels like they're holding back some of the power of the software unless you pay more. With LongTailPro, you can see as many keyword suggestions you like so long as you're within your monthly allowance.
All you would have to do is write a decent review and use some Long Tail marketing keywords scattered inside of it. Do it in a way that the reader doesn't even know you've slipped in 20 long tail keywords. Let the article flow naturally with a clear tone of honesty…as if you were talking to a friend. People who read your review want to feel a connection or a solution or a even a need to buy that product. This is where you use those Long Tail Keywords.
2) SEMrush- This tool offers fantastic competitive research around domains to find what keywords could be driving traffic for your competitors. Looking at paid keywords ad spend can also help you know which keywords might have monetary value worth pursuing organically. If a competitor is willing to spend a high ad budget on terms and you think they do a good job running their ad campaign, then its a good indication it is worth organic ranking effort.
Be sure to re-evaluate these keywords every few months -- once a quarter is a good benchmark, but some businesses like to do it even more often than that. As you gain even more authority in the SERPs, you'll find that you can add more and more keywords to your lists to tackle as you work on maintaining your current presence, and then growing in new areas on top of that.
You can try DeepMiner. It is good for scrapping, rank position, generating long tails and keyword suggestions. You can export the data to document for later analytics. You can find popular keywords that people are searching for. 7 major engines are supported, Google, Yahoo, AOL, Amazon, YouTube, Ask, Bing. It supports multi-threading so it is very very fast scrapper. BTW you must use proxy list if you plan to scrap thousands and thousands of keywords.
I would like to get LTP but I've read that people have some issues according to Keyword Planner and Moz. Do you still recommend this tool? How accurate is it's data comparing to previous versions? Does Keyword difficulty still works as it should? Maybe it's better to wait untill some stability of this software? I don't want to waste money for some tool which doesn't work properly.
The Search Based Keyword Tool is intended for researching keywords within Google's Adwords network. Unlike the Keyword Tool, the Search based Keyword Tool is based solely on searches from Google.com. This factor causes the search volumes displayed to be considerably lower than the Keyword Tool. Because this tool is intended for paid search keyword research, it contains additional information on Suggested Bid and Ad/Search Share. The Search Based Keyword Tool is seamlessly integrated into the Google Adwords interface and allows marketers to add keywords to their PPC campaigns without having to login to their Adwords Client Center.
These keyword research tools should make it easier to create a list of relevant search terms. You should make sure to create awesome landing pages for keywords you want to be found on. You should also think about cornerstone content articles and a great internal linking structure in order to make your SEO strategy complete. In our SEO copywriting course we dive much deeper into keywords, landing pages, and long tail keywords.
* Please note our tool currently assumes Google having ~ 83% of the market, with Bing + Yahoo! splitting the remaining 17% of the market. Actual market conditions may vary significantly from that due to a variety of factors including: search location, search market demographics, how much marketshare mobile search has relative to desktop in that particular vertical, etc.
Most people who use the Google's auto complete feature to generate keywords that they include in their blog title or page find Soovle to be a very useful tool. This tool moves the auto complete feature a step forward by getting inputs from several sources like Amazon, Yahoo, Wikipedia, Bing apart from Google itself. This assists the user to generate keywords that drive online traffic in a better way. The default is usually set to Google but you can switch to the other options at your own will and view how the outcome keeps on changing. You can experiment with a broad range of keywords by running them through a specialized tool such as the keyword inspector as a way of extracting value that will boost your sales on Amazon.
The keywords you want to focus your SEO on should closely resemble the vocabulary of your audience. In order to come up with the proper keywords you really have to get inside the heads of the people who search for your website. What terms will people use? How do people search? Which question does your website answer? You should create a list of all search terms people could use and think of combinations and nuances within these search terms.
If you are looking for keywords in languages other than English, you will find Keyword Tool's features very useful. Keyword Tool allows you to pull keywords from 192 Google domains and use 83 Google language interfaces to generate keyword suggestions. That way we make sure that the generated keywords will be relevant to the country and/or language that you are creating your content for.
This keyword research tool is effective, automatically providing you with keyword suggestions that other sites haven't necessarily turned up (which it's intended to do), along with their search volume, CPC, and Adwords competition. In order to get any actual information about the keywords, though, you need to upgrade to Keyword Tool Pro (which is a little misleading on the site copy). This plan is $88 a month, and if you're just doing keyword research for Google, I'd recommend choosing one of the other tools for the price.
One of the most important aspects of an effective SEO strategy is the ability to research, analyze, and ultimately select the keywords that are most likely to result in success for your clients. There are a variety of free tools available on the web specifically designed to help online marketers do just this. Each tool has its own unique methodology for collecting and presenting this data. Comparing any of the tools' results without knowing the subtle differences can lead to incorrect inferences and an SEO strategy based on misinformation.
KW Finder is similar to the Google Adwords tool; it even pulls up similar results, which aren't as entirely on-point as the immediate results from SEMrush and Moz. From my experience with KW Finder, the searches are a lot better if you put some time into manually adding in filters like negative keywords and additional keywords you do want to include.
Great article again. I was just thinking why can't I find an article of yours on keyword research and then boom here it is. Thanks again. On another subject are your articles on link building still relevant ?. As I have been guilty of as Brian Deane calls it the publish and pray method. I would really like to know what is method of choice for link building. Thanks again Ian.
The program works in different operating systems such as Mac, Windows and other operating systems. If you like, you can install the device in more than one operating system. Many users who have Apples have testified that it works well in that operating system. It means that you can install it in different operating systems without paying additional monies for that. If you want Long Tail Pro to work perfectly, you can run it through Adobe Air. Incidentally, it does not cost you anything to have Adobe Air installed in your operating system. However, you have to ensure that your Adobe Air was updated for you to derive maximum benefit from the program. The program can be tried for ten days free. If you do not like the program after the trial, you can decide to buy it. Moreover, the programs enjoy customer support. It remains the best tool you can rely on to support your internet efforts. Also you can learn more about keyword research from spencer haws Here.
Earlier, I wrote a post about the use of long tail keywords. Focusing on long tail keywords could be a good strategy, especially when trying to rank in a highly competitive market. But how do you decide on which (long tail) keywords you want to rank? This post will give you some handy tips and keyword research tools to make your keyword research a bit easier.
3) Google: This is pretty straight forward but it's the main reason I like it. I search for my main seed keyword in Google, and use the keywords that Google itself highlights in bold on the search results, plus the "Searches related to" section at the bottom to get keyword variations or LSI. That's basically what Google is telling you that topic is about. No need for a thousands other tools. I use these to optimize the on page of my target pages as well.
This isn't the only tool that mines Google Autocomplete. There's also KeywordTool.io, but this tool restricts results to ~700 keywords (more are available for "pro" members). Infinite Suggest is another alternative, but despite the name, I've found that it still doesn't find anywhere near the number of keywords that Keyword Shitter finds. And there are tons of other Google Autocomplete miners too. Just Google "google auto suggest tool" for more. There's also this tool from SEOChat which mines autocomplete suggestions from Google, Bing, Amazon, and YouTube.
As a new customer trying to evaluate the software, I asked if my trial period could be extended once this fundamental issue was fixed, on the basis I couldn't actually evaluate its requirements against my criteria. I was told this was not possible, which frankly, is very poor customer service. What's the point of offering a trial period when customers are unable to fully test the software?
How much is a keyword worth to your website? If you own an online shoe store, do you make more sales from visitors searching for "brown shoes" or "black boots"? The keywords visitors type into search engines are often available to webmasters, and keyword research tools allow us to find this information. However, those tools cannot show us directly how valuable it is to receive traffic from those searches. To understand the value of a keyword, we need to understand our own websites, make some hypotheses, test, and repeat—the classic web marketing formula.
Now that I've been using Long Tail Pro for several years to successfully find great keywords – I can confidently tell you that Long Tail Pro will more than pay for itself if you use it properly. Whether you are a blogger, a niche site creator, an affiliate marketer or even just an article writer – doing proper keyword research will help you be more profitable. Doing proper and effective keyword research with Long Tail Pro is super fast and easy. It's so easy in fact – that it's not hard at all to offset the cost of the software by putting it to work for you. And I'm going to show you how within this post.


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Ontech digital offer online marketing, website designing, graphic designing, app development, website promotion, logo designing etc. We develop and strictly follow the write automatic test programs and design a code for the writing.
For more information to visit :
Job details
- Price
- Free
- Published
- July 20, 2019
- Location
- India, Delhi
- Category
- Technology
- 5084
Useful information
- Avoid scams by acting locally and paying by face to face deal
- Never pay with Western Union, Moneygram or other any other anonymous payment service available in India
- Don't buy or sell outside of India. Don't accept cashier cheques from outside India
- India.Dastiab.com is never involved in any transaction, and does not handle payments online or offline, shipping, guarantee transactions, provide escrow services, or offer "buyer protection" or "seller certification" in any way
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Thorby Wolfking1985 Aug 20, 2015
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Hi. With what SW did you create the Thor? Is it possible to get the files? Want to print it quite large as a birthday present for a friend (huge MW fan) and want to add some more details. Chopping I want do with meshmixxer but I am not sure if I can do all the wanted stuff with meshmixxer? At least the holes in the rocket launcher can be added by a boolschean operation :-) I will cut it exactly in the middle rotation point and either glue it with a rotated torso or make it rotatable..
It is still printable. I will be separating this model soon.
Is it still printable like the models that are cut up? from what I have been reading Im not sure.
Looks incredible though.


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- Project plans
- Project activities
- Legislation and standards
- Industry context
Last edited 25 May 2018
In its broadest sense, the term 'schedule' simply refers to a list. That can be a list of items, activities, events, information and so on. Sometimes schedules will also include dates, such as the dates on which activities listed in the schedule will be carried out (in the construction industry this is more commonly referred to as a programme). Schedules may be appended to other documents, such as contracts.
A project schedule is a graphic presentation of all activities in a project required to produce the output. Gantt Charts, Network Diagrams, CPM and PERT techniques can be used to create the project schedules.
As construction projects and completed buildings are complicated, they take considerable organisation and can involve a number of different types of schedule. Articles on Designing Buildings Wiki about some of the more commonly used schedules include:
- Activity schedule.
- Contractor's working schedule.
- Information release schedule.
- Payment schedule.
- Schedule of condition.
- Schedule of accommodation.
- Schedule of defects.
- Schedule of dilapidations.
- Schedule of drawings.
- Schedule of rates.
- Schedule of services.
- Schedule of tender adjustments.
- Schedule of work.
- Scott schedule.
- Window and door schedules
See also: Programme.
[edit] External references
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Recycle items at the local recycling center if they accept collections. Many recycling sites will pay a small fee per pound of recyclable items. Go around your neighborhood collecting things like glass bottles, soda cans, newspapers, cereal boxes, and milk jugs. Have your parents drive you to the nearest recycling center and turn in your haul in exchange for money.[17]
What are the best ways to make money right away? While a search online when you're in need of some fast cash will produce millions of results, not all will be legitimate. It's up to you to filter through the so-called noise. These 32 strategies will help put you in the black, even if it's in a very small way. Once you are, resume planning and focusing on the bigger picture.
18. CraigsList – Some things don't ship very well. Other things may make you feel uncomfortable to sell to someone across the country. Anytime you're selling a large item or something you just don't want to ship, Craigslist is a great place to go. It's simple to list your item (again, take good pictures!). If you don't like the idea of putting your phone number out there, the interested individual can send you a message to your inbox without even getting your email address.
You will want a website, that is provided for you within Wealthy Affiliate on their top tier hosting. You get this included in your membership. A website is important as it is the foundation for your business (your storefront so to speak). The process is not technical these days so don't be scared by the idea of "creating a website". You are going to be just fine.
Finally, if you're only planning on "dipping your toes in the water" to see what affiliate marketing is all about, do not sign up for the premium membership. The free membership is more than enough for you to see what it's all about. Premium membership should be reserved for those who are actually serious about building a real business for themselves. If you aren't in this for the long-haul, there is no reason to waste your money.
When I say that I love Wealthy Affiliate, I'm not just saying that because I'm an affiliate for them. I'm a very active premium member at Wealthy Affiliate and love interacting with people on a daily basis. If you join, you'll see me posting on people's profiles, answering questions, chatting in the live chat area, and I have private personal messaging conversations multiple times per day.
Warrior Forum WSO's – This is the only option on the list I will actually tell you to stay away from. Warrior Forum WSO's are almost always a rip-off and no amount of them will adequately teach you how to truly build a real online business. This forum community is owned by Freelancer.com and they will allow just about anyone to sell just about anything. The majority of them are very cheap, but once you give them your email address, get ready to be spammed. They also almost always include "upsells" where the initial product may only cost a few bucks, but all the other products they sell you within the first product costs substantially more. I could write all day about why you should never purchase a Warrior Forum WSO, but if you want to learn more, you can read my article about Warrior Forum WSO's here.
…But doesn't being an affiliate for Wealthy Affiliate make me just another one of those affiliate marketers who is being biased and just trying to make a buck off of you? Well, ummmm…. Sort of! But at least I'm honest about it, right? I hope you give me a chance by continuing to read this Wealthy Affiliate review. I have no intention of making this one big sales pitch. I just want to provide you with the information and allow you to make your own decision. If I get a commission, great! If not, that's ok too. Here's a screenshot of my Wealthy Affiliate profile.
sounds very good. just yesterday I invested in Steve's stealmysite (or system) and ended up paying for that and coolhanle. And they took all I had in my savings and drained my checking account very upsetting. And when I talked them on the phone they had me almost in tears because i didn't have money. I don't like to be where I'm at. I want to better myself. Thank you for offering yours to try free. That is so fantastic.
You may find the odd negative review out there from a "competitor" or someone promoting a competing product. That happens. There are also many frustrated business owners in the industry that are offering low quality products, that get frustrated that they cannot compete with the services offer at Wealthy Affiliate. What they offer within their premium membership for $359 per year, there are companies charging $10,000's for FAR LESS.
JVZoo's strength is that it allows experienced marketers to gain access to product launches and a huge range of online courses while setting up sales funnels and customized landing pages. It's definitely not for someone who wants to monetize a blog or earn money by having users click through and buy physical products. If you've carved out a strong presence online in the marketing space, JVZoo might be a perfect fit.


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Grapefruit Shatter
Out of stock
Rated 5.00 out of 5 based on 1 customer rating(1 customer review)
$45.00 – $510.00
Grapefruit Shatter pricing is as follows:
- $45 for 2 grams = $22.50 per gram
- $130 for 6 grams = $21.66 per gram
- $250 for 12 grams = $20.83 per gram
- $355 for 18 grams = $19.72 per gram
- $510 for 28 grams = $18.21 per gram
taste: citrus, grapefruit, sweet
may relieve: chronic pain, depression, fatigue, migraines
SKU: N/A Category: Out of stock Tags: bho, pain, shatter
Grapefruit is a longtime marijuana classic, a heady blend of the hybrid Cinderella 99 and a sativa bred specifically for its grapefruit flavor. With a sativa/indica ratio of 70:30, this strain packs a decidedly cerebral punch, with a major mood boost and intense euphoria. THC levels have been charted at 20%, so this is a pretty powerful strain. CBD levels, meanwhile, are very low, ruling this out as an effective treatment for epilepsy. But it's highly effective at relieving anxiety and depression, as well as pain, GI distress, and PMS. The sweet taste and smell of grapefruit are dominant, thought there are also hints of other citrus fruits. Adverse effects are usually quite limited, though dry mouth and red eyes are possible. Dizziness and paranoia are more rare. Grapefruit is common across the country, sold largely on the basis of its unique flavor and aroma. It's most popular in Colorado and on the West Coast, though it can also be found in other legal markets and the black market. This strain is highly appealing to smokers looking for a strong head high, less so to patients seeking physical effects.
2 Grams, 6 Grams, 12 Grams, 18 Grams, 28 Grams
1 review for Grapefruit Shatter
Rated 5 out of 5
Dragon6 (verified owner) –
Perfect for daytime tokes
Earn 25 points by reviewing this product.
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Born in Tokyo and raised in New Zealand, Kat McDowell makes music with an Ocean Pop sound delivered in a blend of Japanese and English that is uniquely her own.
This effortless pop track reinforces Harry's rise on the New Zealand pop scene.
A collection of five laid back, introspective progressive rock songs with a dreamy psychedelic mood.
Sportsman of the Year will be an entertaining and inspirational evening and is not to be missed.


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That makes sense, given its German Opel roots. We were very impressed with the acceleration performance from the available 3. The steering is precise and properly weighted, allowing easy maneuverability in parking lots while providing a solid, confident feel at speed on winding roads and interstate freeways. We've been lucky to have a car like this and I'm now training my 16-year old son on it. The Hybrid gets four-wheel anti-lock disc brakes with good stopping power and StabiliTrak for added safety , but attempts at gradual, smooth braking are still met with unpredictable lurches from the hybrid system.
The Nissan dealer offered a special lease on the Rogue. Red Line models get unique, leather-trimmed sport seats. I think that Onstar is the coolest!! To see what's new for 2009, , or check out a of the two model years. Family buyers will undoubtedly be impressed by the Saturn Vue Hybrid's safety credentials, which rank among the highest in the industry. The Vue's front seats lack good support and contouring, and there's unappealing hard plastic throughout the interior, but it's marked by plenty of storage cubbies and a simple, straightforward instrument-panel layout. The power steering is not overboosted or mushy, and has good but not great road feel. The driver's bucket seat is comfy, containing but not restrictive.
Can fit a double sit n stand stroller and then some! The figures are lower than they would be using the 2007 method. We have giant car seats for the two kids and they fit perfectly in the car. The interior is attractive and European in style, modern and classy, with comfortable seats. We are already on record complaining that the Vue is bigger than a Ford Escape on the outside and smaller inside. Gets about 22mpg in the winter and about 25mpg in the summer. Summary The Saturn Vue is a nice compact crossover utility vehicle, certainly one of the best in its segment.
The 2009 Saturn Vue is available in three trim levels, with three engines, two transmissions and a choice of front-wheel drive or all-wheel drive. It does have some downsides, however, such as a lack of cargo space, lackluster fuel economy and pricing that's typically a couple thousand dollars more than the competition. It has a ton of space for passengers, comfortable road trip vehicle. I am very pleased with the space provided and the flexibility of the seating for hauling larger items. Saturn has given the Vue a generous level of safety equipment.
Saturn has chosen brushed metal over shiny chrome, which avoids problems with fingerprints and sun reflections, and for that we give high marks. Gas milage is not too bad for a 3. Not long after, I was a guest of Honda's at the Twin Ring Motegi racetrack in Japan. Who knows what became of the Ford talks? Rear passengers are treated to an upscale cupholder that exemplifies how superior even the most minute interior features are in the Vue. The hybrid Vue Green Line will be on the market in late summer, with a high-performance model called the Red Line to follow in the fall. If you happen to glance under the hood of the 2009 Saturn Vue Hybrid, Cars.
Send David an Hide full review. The large chrome grille and teardrop-shaped headlights are probably the most masculine attributes, while the downward-sloping roof, ending in a radically angled rear hatch, exudes European design. Three powertrains are available: The 2. Just enjoy it, and don't ask probing questions. And for 2009, the Saturn Vue remains a well-rounded player, thanks to its smart Euro-based design it's a twin to the European Opel Antara that combines good looks, a welcoming cabin and solid driving dynamics. I would recommend this vehicle to almost anyone only sorry they quit making them when Saturn was forced out of the market by the bail-out.
There is also a provision in the stability system to prevent trailers from dangerous swaying. I can't wait till the kids outgrow the car seats and we can real. The Vue uses the same underpinnings as the European Opel Antara, tuned for America, which means simple, effective MacPherson strut front suspension with coil springs, and independent rear suspension with trailing arms, coil springs, and lateral locating links. It also permits the engine to shut off at stoplights in drive, restarting it quickly when you back off the brake pedal. Driving Impressions Compared with other five-seat crossover utility vehicles from the Japanese, Korean, European and domestic competition, the Saturn Vue behaves more like a European vehicle. It's connected to a six-speed automatic transmission.
This feature was mostly praised by the staff, with the exception of one lone detractor. I would buy this car over again. While the 2009 Saturn Vue Hybrid can compete in terms of interior quality, it suffers from a lack of space that some consumers might consider a deal-breaker. Well, more of a growling value. There was ample acceleration it manages zero to 60 in an impressive 6. I generally get about 300+ miles in the city on one tank of gas. It boasts very good performance, real room for five, storage possibilities galore, and tons of personality.
And many find it's just the right size. Brushed-aluminum accents on the steering wheel, door panels, parking brake and shift knob further the upscale treatment. Inside, the Vue is nicely designed, and it would be a good vehicle either for young families or those who have issues with entry and exit, as the seating position is very easy to sit in, given the high roofline. . The Vue Hybrid rides quite harshly as well. The more advanced Saturn Vue 2 Mode Hybrid model originally promised for 2009 will instead be arriving for 2010, alongside this existing Vue Hybrid model.


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PREORDER – Spider-Man: Homecoming – Spider-Man (Deluxe Version) Quarter Scale Figure QS by Hot Toys
** Spedizione Italia – € 10,00 **
Arrivo Previsto: Q1 2021 (Febbraio)
** I prezzi indicati possono essere soggetti a variazione in funzione dei cambi **
** Prices indicated may vary in accordance to currency fluctuations **
** Down Payment: € 195,00 **
** Expected Arrival: Q1 2021 (February)**
** Contact us for International shipping **
"So, to become an Avenger, are there like trials?" – Peter Parker
In response to the enormous popularity of the collectibles created based on "Spider-Man: Homecoming", Hot Toys is extremely thrilled to present an upgraded version of your friendly neighborhood superhero inspired by the movie arriving in quarter scale with amazing details!
The screen-accurate 1:4 scale Spider-Man collectible figure is crafted based on the battling suit given to Peter Parker by Tony Stark and features a newly developed masked head sculpt with five pairs of interchangeable eyepieces to create numerous combinations of expressions. The newly developed interchangeable head sculpt has a remarkable likeness of Tom Holland. This figure boasts a newly developed specialized body that stands approximately 43.5cm tall, an expertly tailored and greatly detailed costume, a pair of magnetically attachable web-wings, an array of accessories including a Spider Drone, a projection mapping, a smartphone, a backpack, a mask, a variety of spider-web shooting effect parts, and a LED light-up diorama figure base with two lighting modes for alternative display inspired by the final fight scene between Spider-Man and The Vulture.
The deluxe version will exclusively feature additional Vulture themed diorama parts designed to be interchangeable for passionate fans to develop their unique diorama display!
Spider-Man fanatics surely can't pass up on the opportunity to have this wonderful collectible figure in your display!
More Images: Hot Toys Limited
Galleria Immagini
Product Details
Expected to Ship: Oct 2020 – Dec 2020
License: Marvel
Type: Quarter Scale Figure
Manufacturer: Hot Toys
Product Sku: 904920
Product Code: QS015
Product Name: Spider-Man (Deluxe Version)
Product Size: 17.12″ H (434.85 mm)
• So Young Jang (Head Sculpt)
• E-Lee & JC. Hong (Head Paint)
• JC. Hong (Head Art Direction)
• Studio HIVE (Diorama Figure Base Design)
Contenuto Box Spider-Man (Deluxe Version) Quarter Scale Figure specially features:
• An authentic and detailed likeness of Spider-Man in "Spider-Man: Homecoming"
• Newly developed interchangeable head sculpt with authentic likeness of Tom Holland as Peter Parker
• Five (5) pairs of interchangeable Spider-Man eyepieces that can create numerous combinations of expressions
• Newly developed body with 31 points of articulation
• Ten (10) pieces of interchangeable hands with black cobweb pattern including:
– One (1) pair of fists
– One (1) pair of relaxed hands
– One (1) pair of hands for cobweb shooting
– One (1) pair of hands for cobweb swinging
– One (1) pair of open hands
• Each head sculpt is specially hand-painted
• One (1) newly developed red and blue colored Spider-Man suit embossed with grayish black trims, cobweb pattern and black spider emblem on chest
• One (1) pair of red-color boots embossed with grayish black cobweb pattern
• One (1) pair of black colored web shooter
• One (1) pair of magnetic web-wings
• One (1) Spider Drone
• One (1) GPS projection mapping
• One (1) smartphone
• One (1) beige backpack
• One (1) Spider-Man mask (not wearable on figure)
• Four (4) strings of spider web in different shapes and lengths, attachable to the web-shooters
• One (1) open spider web effect accessory
• Three (3) interchangeable Vulture themed diorama accessories***
• A specially designed Spider-Man vs. Vulture fight inspired diorama dynamic figure base features 2 LED lighting modes including general light effect and breathing light effect (battery operated)
*** Exclusive to Deluxe Version
Item shown is a prototype. When shipped, the final production piece may differ in appearance.
© MARVEL © 2019 CPII. All Rights Reserved.
© 2019 Hot Toys Limited. All Rights Reserved.


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Cal-Mil 1433-3-55 Large Stainless Steel Curl Riser - 18" x 6" x 6"
- Great for serving appetizers and desserts
- Durable, easy-to-clean stainless steel
- Display bowls and plates
- Perfect for buffets and catered events
- Other risers sold separately
Showcase your culinary creations with Cal-Mil's wide variety of risers! With styles and materials ranging from metal, bamboo, wood, plastic, and more, these risers are sure to give your food the display it deserves!
|Cal-Mil 1433-3-55 Specs
|18 Inches
|6 Inches
|6 Inches
|Made in America
|Stainless Steel
|Number of Tiers
Cal-Mil 1433-3-55 Details
Take appetizer and dessert service to a new level with the Cal-Mil 1433-3-55 large stainless steel curl riser. This stainless steel riser allows you to show off plates, bowls, and more, and its unique curl shape is perfect for drawing your guests' attention to hors d'oeuvres, signature small plates, and desserts. Ideal for catered events, parties or display areas of your restaurant, buffet or bistro, this riser will complement any decor. You can use this riser on its own or pair it with additional curl risers of varying sizes (sold separately) for a stunning, multi-tier presentation of all your customers' favorites!
Overall Dimensions:
Length: 18"
Width: 6"
Height: 6"
Because this item is not stocked in our warehouse, processing, transit times and stock availability will vary. If you need your items by a certain date,
please contact us prior to placing your order. Expedited shipping availability may vary. We cannot guarantee that this item can be cancelled off of the order or returned once it is placed.
Made in America
This item was made in the United States of America.
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Auctions Every Sunday at 12pm and 3pm Viewing Times & Valuation Hours
Lot 612, Sunday 4th November. Return to Catalogue
Hammer Price £400
Estimate £450 - £550
Plus 26.4% buyers premium inclusive of VAT
Brown leather finish, 215cm wide.
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TWO MEN AND A TRUCK® marketing manager Justin Greear stopped by the WDTN newsroom to showcase some Valentine's Day crafts including several different Valentine's Day card boxes that children can easily create and carry to school for their class parties.
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text: Cancer Immunology Research current issue http://cancerimmunolres.aacrjournals.org Cancer Immunology Research RSS feed -- current issue 2326-6074 August 2019 Cancer Immunology Research 2326-6066 Cancer Immunology Research http://cancerimmunolres.aacrjournals.org/icons/banner/title.gif http://cancerimmunolres.aacrjournals.org http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1223?rss=1 2019-08-01T00:05:27-07:00 hwp:resource-id:canimm;7/8/1223 American Association for Cancer Research 2019-08-01 What We're Reading 7 8 1223 1223 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1224?rss=1 Immune checkpoints and agonists modulate ongoing, antigen-specific immune responses. Therapeutic blockade of CTLA-4, PD-1, and PD-L1 has proven to be an effective treatment approach for a subset of patients with a variety of cancers of epithelial, mesenchymal, or hematologic origin. In multiple myeloma, a B-cell lymphoid malignancy of terminally differentiated plasma cells, PD-1 pathway blockade is ineffective as a single agent. The initial promise in combination approaches utilizing anti–PD-1 with the immunomodulatory drugs, lenalidomide or pomalidomide, was not confirmed in randomized trials. Here, we explore available data for and against manipulation of the PD-1 pathway and other immune checkpoints in myeloma and highlight several promising concepts and challenges that face ongoing development of immunotherapeutics for this disease. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-19-0148 hwp:resource-id:canimm;7/8/1224 American Association for Cancer Research 2019-08-01 Cancer Immunology at the Crossroads 7 8 1224 1229 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1230?rss=1 Immunotherapy with checkpoint inhibitors, such as the programmed death-1 (PD-1) antibodies pembrolizumab and nivolumab, are effective in a variety of tumors, yet not all patients respond. Tumor microsatellite instability-high (MSI-H) has emerged as a biomarker of response to checkpoint blockade, leading to the tissue agnostic approval of pembrolizumab in MSI-H cancers. Here we describe a patient with MSI-H colorectal cancer that was treated with this immune checkpoint inhibitor and exhibited progression of disease. We examined this intrinsic resistance through genomic, transcriptional, and pathologic characterization of the patient's tumor and the associated immune microenvironment. The tumor had typical MSI-H molecular features, including a high neoantigen load. We also identified biallelic loss of the gene for β2-microglobulin (B2M), whose product is critical for antigen presentation. Immune infiltration deconvolution analysis of bulk transcriptome data from this anti-PD-1–resistant tumor and hundreds of other colorectal cancer specimens revealed a high natural killer cell and M2 macrophage infiltration in the patient's cancer. This was confirmed by single-cell transcriptome analysis and multiplex immunofluorescence. Our study provides insight into resistance in MSI-H tumors and suggests immunotherapeutic strategies in additional genomic contexts of colorectal cancer. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0683 hwp:master-id:canimm;2326-6066.CIR-18-0683 American Association for Cancer Research 2019-08-01 Cancer Immunology Miniatures 7 8 1230 1236 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1237?rss=1 Interferon- (IFN) has been studied as a cancer treatment with limited evidence of clinical benefit. However, it could play a role in cancer immunotherapy combination treatments. Despite high expression of immunogenic cancer–testis antigens, synovial sarcoma (SS) and myxoid/round cell liposarcoma (MRCL) have a cold tumor microenvironment (TME), with few infiltrating T cells and low expression of major histocompatibility complex class I (MHC-I). We hypothesized that IFN treatment could drive inflammation in a cold TME, facilitating further immunotherapy. We conducted a phase 0 clinical trial treating 8 SS or MRCL patients with weekly systemic IFN. We performed pre- and posttreatment biopsies. IFN changed the SS and MRCL TME, inducing tumor-surface MHC-I expression and significant T-cell infiltration (P < 0.05). Gene-expression analysis suggested increased tumor antigen presentation and less exhausted phenotypes of the tumor-infiltrating T cells. Newly emergent antigen-specific humoral and/or T-cell responses were found in 3 of 7 evaluable patients. However, increased expression of PD-L1 was observed on tumor-infiltrating myeloid cells and in some cases tumor cells. These findings suggest that systemic IFN used to convert SS and MRCL into "hot" tumors will work in concert with anti–PD-1 therapy to provide patient benefit. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0940 hwp:master-id:canimm;2326-6066.CIR-18-0940 American Association for Cancer Research 2019-08-01 Priority Brief 7 8 1237 1243 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1244?rss=1 Therapeutic strategies are urgently needed for patients with acute myeloid leukemia (AML). Leukocyte immunoglobulin-like receptor B4 (LILRB4), which suppresses T-cell activation and supports tissue infiltration of AML cells, represents an attractive drug target for anti-AML therapeutics. Here, we report the identification and development of an LILRB4-specific humanized mAb that blocks LILRB4 activation. This mAb, h128-3, showed potent activity in blocking the development of monocytic AML in various models including patient-derived xenograft mice and syngeneic immunocompetent AML mice. MAb h128-3 enhanced the anti-AML efficacy of chemotherapy treatment by stimulating mobilization of leukemia cells. Mechanistic studies revealed four concordant modes of action for the anti-AML activity of h128-3: (i) reversal of T-cell suppression, (ii) inhibition of monocytic AML cell tissue infiltration, (iii) antibody-dependent cellular cytotoxicity, and (iv) antibody-dependent cellular phagocytosis. Therefore, targeting LILRB4 with antibody represents an effective therapeutic strategy for treating monocytic AML. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-19-0036 hwp:master-id:canimm;2326-6066.CIR-19-0036 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1244 1257 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1258?rss=1 Multiple studies have associated the transcription factor IRF1 with tumor-suppressive activities. Here, we report an opposite tumor cell–intrinsic function of IRF1 in promoting tumor growth. IRF1-deficient tumor cells showed reduced tumor growth in MC38 and CT26 colon carcinoma and B16 melanoma mouse models. This reduction in tumor growth was dependent on host CD8+ T cells. Detailed profiling of tumor-infiltrating leukocytes did not show changes in the various T-cell and myeloid cell populations. However, CD8+ T cells that had infiltrated IRF1-deficieint tumors in vivo exhibited enhanced cytotoxicity. IRF1-deficient tumor cells lost the ability to upregulate PD-L1 expression in vitro and in vivo and were more susceptible to T-cell–mediated killing. Induced expression of PD-L1 in IRF1-deficient tumor cells restored tumor growth. These results indicate differential activity of IRF1 in tumor escape. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0711 hwp:master-id:canimm;2326-6066.CIR-18-0711 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1258 1266 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1267?rss=1 Human tumor xenograft models do not replicate the human immune system and tumor microenvironment. We developed an improved humanized mouse model, derived from fresh cord blood CD34+ stem cells (CD34+ HSC), and combined it with lung cancer cell line–derived human xenografts or patient-derived xenografts (Hu-PDX). Fresh CD34+ HSCs could reconstitute detectable mature human leukocytes (hCD45+) in mice at four weeks without the onset of graft-versus-host disease (GVHD). Repopulated human T cells, B cells, natural killer (NK) cells, dendritic cells (DC), and myeloid-derived suppressor cells (MDSC) increased in peripheral blood, spleen, and bone marrow over time. Although cultured CD34+ HSCs labeled with luciferase could be detected in mice, the cultured HSCs did not develop into mature human immune cells by four weeks, unlike fresh CD34+ HSCs. Ex vivo, reconstituted T cells, obtained from the tumor-bearing humanized mice, secreted IFN upon treatment with phorbol myristate acetate (PMA) or exposure to human A549 lung tumor cells and mediated antigen-specific CTL responses, indicating functional activity. Growth of engrafted PDXs and tumor xenografts was not dependent on the human leukocyte antigen status of the donor. Treatment with the anti–PD-1 checkpoint inhibitors pembrolizumab or nivolumab inhibited tumor growth in humanized mice significantly, and correlated with an increased number of CTLs and decreased MDSCs, regardless of the donor HLA type. In conclusion, fresh CD34+HSCs are more effective than their expanded counterparts in humanizing mice, and do so in a shorter time. The Hu-PDX model provides an improved platform for evaluation of immunotherapy. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0874 hwp:master-id:canimm;2326-6066.CIR-18-0874 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1267 1279 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1280?rss=1 Natural killer (NK) cells can orchestrate effective antitumor immunity. The presence of tumor-infiltrating NK cells in diagnostic biopsies predicts pathologic complete response (pCR) to HER2-specific therapeutic antibodies in patients with primary breast cancer. Here, we analyzed whether diversity in circulating NK cells might influence tumor infiltration and HER2-specific therapeutic antibody efficacy. We found that numbers of circulating CD57+ NK cells inversely correlated with pCR to HER2-specific antibody treatment in patients with primary breast cancer independently of age, traditional clinicopathologic factors, and CD16A 158F/V genotype. This association was uncoupled from the expression of other NK-cell receptors, the presence of adaptive NK cells, or changes in major T-cell subsets, reminiscent of cytomegalovirus-induced immunomodulation. NK-cell activation against trastuzumab-coated HER2+ breast cancer cells was comparable in patients with high and low proportions of CD57+ NK cells. However, circulating CD57+ NK cells displayed decreased CXCR3 expression and CD16A-induced IL2-dependent proliferation in vitro. Presence of CD57+ NK cells was reduced in breast tumor–associated infiltrates as compared with paired peripheral blood samples, suggesting deficient homing, proliferation, and/or survival of NK cells in the tumor niche. Indeed, numbers of circulating CD57+ were inversely related to tumor-infiltrating NK-cell numbers. Our data reveal that NK-cell differentiation influences their antitumor potential and that CD57+ NK cells may be a biomarker useful for tailoring HER2 antibody–based therapeutic strategies in breast cancer. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0896 hwp:master-id:canimm;2326-6066.CIR-18-0896 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1280 1292 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1293?rss=1 Immunotherapy treatments with anti-PD-1 boost recovery in less than 30% of treated cancer patients, indicating the complexity of the tumor microenvironment. Expression of HLA-E is linked to poor clinical outcomes in mice and human patients. However, the contributions to immune evasion of HLA-E, a ligand for the inhibitory CD94/NKG2A receptor, when expressed on tumors, compared with adjacent tissue and peripheral blood mononuclear cells, remains unclear. In this study, we report that epithelial-derived cancer cells, tumor macrophages, and CD141+ conventional dendritic cells (cDC) contributed to HLA-E enrichment in carcinomas. Different cancer types showed a similar pattern of enrichment. Enrichment correlated to NKG2A upregulation on CD8+ tumor-infiltrating T lymphocytes (TIL) but not on CD4+ TILs. CD94/NKG2A is exclusively expressed on PD-1high TILs while lacking intratumoral CD103 expression. We also found that the presence of CD94/NKG2A on human tumor–specific T cells impairs IL2 receptor–dependent proliferation, which affects IFN-mediated responses and antitumor cytotoxicity. These functionalities recover following antibody-mediated blockade in vitro and ex vivo. Our results suggest that enriched HLA-E:CD94/NKG2A inhibitory interaction can impair survival of PD-1high TILs in the tumor microenvironment. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0885 hwp:master-id:canimm;2326-6066.CIR-18-0885 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1293 1306 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1307?rss=1 Therapies using NK cells (NKc) expanded/activated ex vivo or stimulated in vivo with new immunostimulatory agents offer alternative opportunities for patients with recurrent/refractory tumors, but relevant biomarkers to guide the selection of patients are required for optimum results. Overall survival of 249 solid cancer patients was evaluated in relation to the genetics and/or the expression on peripheral blood NKcs of inhibitory and activating killer-cell immunoglobulin-like receptors (iKIR and aKIR, respectively), HLA class I ligands, CD226 (also known as DNAM-1), and NKG2A. Compared with patients with higher expression, patients with low expression of CD226 on total NKcs showed shorter mean overall survival (60.7 vs. 98.0 months, P < 0.001), which was further reduced in presence of telomeric aKIRs (KIR2DS1-DS5 and/or KIR3DS1, 31.6 vs. 96.8 months, P < 0.001). KIR2DL2/S2+, KIR3DL1+, KIR2DL1+, and KIR2DL3+ NKc subsets in the presence of their cognate ligands primarily contributed to shortening patients' overall survival by increasing the sensitivity to CD226 downmodulation in aKIR-rich telomeric genotypes. In patients with high tumor burden who died during the follow-up period, aKIR-rich telomeric genotypes were associated with: (i) specific downmodulation of CD226 on educated NKcs but not on CD8+ T cells or uneducated NKcs, (ii) lower expression of CD226 and higher expression of NKG2A on aKIR+ NKcs, and (iii) lower numbers of total CD56dim NKcs. The reduced expression of CD226 on NKcs with aKIR-rich genotypes may be a biomarker indicative of NKc hyporesponsiveness in patients that could benefit from new NKc immune-stimulatory therapies. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0847 hwp:master-id:canimm;2326-6066.CIR-18-0847 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1307 1317 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1318?rss=1 PD1 blockade is effective in a subset of patients with B-cell lymphoma (e.g., classical-Hodgkin lymphomas); however, most patients do not respond to anti-PD1 therapy. To study PD1 resistance, we used an isoform-selective histone deacetylase inhibitor (HDACi; OKI-179), and a mouse mature B-cell lymphoma, G1XP lymphoma, immunosuppressive features of which resemble those of human B-cell lymphomas, including downregulation of MHC class I and II, exhaustion of CD8+ and CD4+ tumor-infiltrating lymphocytes (TIL), and PD1-blockade resistance. Using two lymphoma models, we show that treatment of B-cell lymphomas refractory to PD1 blockade with both OKI-179 and anti-PD1 inhibited growth; furthermore, sensitivity to single or combined treatment required tumor-derived MHC class I, and positively correlated with MHC class II expression level. We conclude that OKI-179 sensitizes lymphomas to PD1-blockade by enhancing tumor immunogenicity. In addition, we found that different HDACis exhibited distinct effects on tumors and T cells, yet the same HDACi could differentially affect HLA expression on different human B-cell lymphomas. Our study highlights the immunologic effects of HDACis on antitumor responses and suggests that optimal treatment efficacy requires personalized design and rational combination based on prognostic biomarkers (e.g., MHCs) and the individual profiles of HDACi. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0875 hwp:master-id:canimm;2326-6066.CIR-18-0875 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1318 1331 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1332?rss=1 The escape of cancer cells from host immunosurveillance involves a shift in immune responses, including an imbalance in Th1 and Th2 cells. A Th1-dominated immune response predicts positive outcomes in colorectal cancer. The E3 ubiquitin ligase, Asb2α, is expressed in Th2 cells, but its roles in T-cell maturation and cancer are unclear. We provide evidence that the Th2 master regulator, Gata3, induces Asb2. Loss of Asb2 did not affect Th differentiation ex vivo, but reduced IL4 production from Th2 cells. We found that high ASB2 expression was associated with poor outcome in colorectal cancer. Loss of Asb2 from hematopoietic cells promoted a Th1 response and attenuated colitis-associated tumorigenesis in mice. Diminished Th2 function correlated with increased IFN production and an enhanced type 1 antitumor immune response in Asb2-deficient mice. Our work suggests that Asb2α promotes a Th2 phenotype in vivo, which in turn is associated with tumor progression in a mouse model of colitis. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0562 hwp:master-id:canimm;2326-6066.CIR-18-0562 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1332 1344 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1345?rss=1 Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in lymphatic function result in accumulation of inflammatory cells with an immunosuppressive profile. We tested the hypothesis that dysfunctional lymphatic vessels surrounding solid tumors regulate changes in the tumor microenvironment and tumor-specific immune responses. Using subcutaneously implanted mouse melanoma and breast cancer tumors in a lymphatic endothelial cell–specific diphtheria toxin receptor transgenic mouse, we found that local ablation of lymphatic vessels increased peritumoral edema, as compared with controls. Comparative analysis of the peritumoral fluid demonstrated increases in the number of macrophages, CD4+ inflammatory cells, F4/80+/Gr-1+ (myeloid-derived suppressor cells), CD4+/Foxp3+ (Tregs) immunosuppressive cells, and expression of inflammatory cytokines such as TNFα, IFN, and IL1β following lymphatic ablation. Tumors grown in lymphatic ablated mice exhibited reduced intratumoral accumulation of cytotoxic T cells and increased tumor PD-L1 expression, causing rapid tumor growth, compared with tumors grown in nonlymphatic-ablated mice. Our study suggests that lymphatic dysfunction plays a role in regulating tumor microenvironments and may be therapeutically targeted in combination with immunotherapy to prevent tumor growth and progression. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0337 hwp:master-id:canimm;2326-6066.CIR-18-0337 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1345 1358 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1359?rss=1 Progressive tumor growth is associated with deficits in the immunity generated against tumor antigens. Vaccines targeting tumor neoepitopes have the potential to address qualitative defects; however, additional mechanisms of immune failure may underlie tumor progression. In such cases, patients would benefit from additional immune-oncology agents targeting potential mechanisms of immune failure. This study explores the identification of neoepitopes in the MC38 colon carcinoma model by comparison of tumor to normal DNA and tumor RNA sequencing technology, as well as neoepitope delivery by both peptide- and adenovirus-based vaccination strategies. To improve antitumor efficacies, we combined the vaccine with a group of rationally selected immune-oncology agents. We utilized an IL15 superagonist to enhance the development of antigen-specific immunity initiated by the neoepitope vaccine, PD-L1 blockade to reduce tumor immunosuppression, and a tumor-targeted IL12 molecule to facilitate T-cell function within the tumor microenvironment. Analysis of tumor-infiltrating leukocytes demonstrated this multifaceted treatment regimen was required to promote the influx of CD8+ T cells and enhance the expression of transcripts relating to T-cell activation/effector function. Tumor-targeted IL12 resulted in a marked increase in clonality of T-cell repertoire infiltrating the tumor, which when sculpted with the addition of either a peptide or adenoviral neoepitope vaccine promoted efficient tumor clearance. In addition, the neoepitope vaccine induced the spread of immunity to neoepitopes expressed by the tumor but not contained within the vaccine. These results demonstrate the importance of combining neoepitope-targeting vaccines with a multifaceted treatment regimen to generate effective antitumor immunity. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0620 hwp:master-id:canimm;2326-6066.CIR-18-0620 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1359 1370 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1371?rss=1 Antibodies targeting CTLA-4 induce durable responses in some patients with melanoma and are being tested in a variety of human cancers. However, these therapies are ineffective for a majority of patients across tumor types. Further understanding the immune alterations induced by these therapies may enable the development of novel strategies to enhance tumor control and biomarkers to identify patients most likely to respond. In several murine models, including colon26, MC38, CT26, and B16 tumors cotreated with GVAX, anti–CTLA-4 efficacy depends on interactions between the Fc region of CTLA-4 antibodies and Fc receptors (FcR). Anti–CTLA-4 binding to FcRs has been linked to depletion of intratumoral T regulatory cells (Treg). In agreement with previous studies, we found that Tregs infiltrating CT26, B16-F1, and autochthonous BrafV600EPten–/– melanoma tumors had higher expression of surface CTLA-4 (sCTLA-4) than other T-cell subsets, and anti–CTLA-4 treatment led to FcR-dependent depletion of Tregs infiltrating CT26 tumors. This Treg depletion coincided with activation and degranulation of intratumoral natural killer cells. Similarly, in non–small cell lung cancer (NSCLC) and melanoma patient-derived tumor tissue, Tregs had higher sCTLA-4 expression than other intratumoral T-cell subsets, and Tregs infiltrating NSCLC expressed more sCTLA-4 than circulating Tregs. Patients with cutaneous melanoma who benefited from ipilimumab, a mAb targeting CTLA-4, had higher intratumoral CD56 expression, compared with patients who received little to no benefit from this therapy. Furthermore, using the murine CT26 model we found that combination therapy with anti–CTLA-4 plus IL15/IL15Rα complexes enhanced tumor control compared with either monotherapy. ]]> 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-18-0386 hwp:master-id:canimm;2326-6066.CIR-18-0386 American Association for Cancer Research 2019-08-01 Research Articles 7 8 1371 1380 http://cancerimmunolres.aacrjournals.org/cgi/content/short/7/8/1381?rss=1 2019-08-01T00:05:27-07:00 info:doi/10.1158/2326-6066.CIR-19-0440 hwp:resource-id:canimm;7/8/1381 American Association for Cancer Research 2019-08-01 Correction 7 8 1381 1381


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2nd Annual MakeHER Summit Workshops
Mon Oct 28, 10am–3pm
Presented by: National Museum of Women in the Arts
Tickets · $20-25
Official website
This day of meaningful connection and deep-dive workshops will offer practical tips and resources for creative entrepreneurs at all levels. Workshops are designed for entrepreneurs looking for guidance, interested in growing their networks, and hungry for new tools to help their creative endeavors thrive. Workshop presenters include Washington Area Lawyers for the Arts and more to be announced closer to the event.
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