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Português: Ganhar Dinheiro com o Programa de Afiliados Amazon, Español: ganar dinero con el programa de afiliados de Amazon, Deutsch: Mit dem Amazon Partnerprogramm Geld verdienen, Русский: зарабатывать деньги с помощью партнерской программы Amazon, Italiano: Guadagnare con il Programma di Affiliazione Amazon, Français: gagner de l'argent grâce au programme Amazon Partenaires, Bahasa Indonesia: Menghasilkan Uang dengan Mengikuti Amazon Affiliate Program, Nederlands: Geld verdienen met het Amazon Affiliate Programma, العربية: ربح الأموال من برنامج المشاركة التسويقية على أمازون
23. Affiliates – There are many affiliate networks, such as FlexOffers and CJ Affiliate that allow you to promote other people's products and services. You simply put a link or a banner on your page and then you get a percentage if someone clicks through and buys the product/service. You'll want to select products that are specifically within your blog's category.This is an effective way to earn money once you have the traffic coming to your blog.
Hi, I joined Wealthy Affiliate several years ago for a very short period of time. I needed to earn money quickly and didn't have enough knowledge to know that creating a business took much time. I couldn't afford to continue with the program. My priorities have changed and God has blessed me enough that I am now able to afford the program. I would like to re-join with the monthly plan for a couple of months before I take the yearly plunge. Am I able to get the $19.00 first month fee or do I have to start at $49.00?
Be professional. When you submit a résumé, don't type it in ALL CAPS and please don't avoid the caps lock like the plague. Know how to use it without looking incompetent. Write in complete sentences with proper grammar. Of course, there will be exceptions, but even with the exceptions, you must keep it professional. You're building their view of you.
Recycle items at the local recycling center if they accept collections. Many recycling sites will pay a small fee per pound of recyclable items. Go around your neighborhood collecting things like glass bottles, soda cans, newspapers, cereal boxes, and milk jugs. Have your parents drive you to the nearest recycling center and turn in your haul in exchange for money.[17]
On WA coaching material there is no separate indexing of the "lessons". A point missed can be found again but not by going through any master index which would be crossreferencing ideas & locations...thus depriving us of a a way to get back to where ideas are first presented in the training. Without that we are forced to stumble through videos again and again which is very frustrating & time consuming activity or we must ask people instead. This flaw in the training presentation makes me wonder if the clumsier and slower learning which might result...is as "rewarding" to the CEO (in the form of longer lasting subscriptions) as is is "punishing" to the member?
I joined WA a few months and a premium member now. For the 1st time, I am reading WA from outside. I decided to join WA by reading a few articles from the web which I really liked. There is not a single day I have not enjoyed. Every day I see people converting, sites getting ranked, people getting to 1st page, even ranked #1 of Goole. It is lots of hard work and you got to be a skilled writer in your niche. The community help is unparallel. The longest I have seen the conversion is 3.5 years. But the person said he started the website before completing the training and made a mistake. He was about to give up when he saw 4 figure/ month conversion. He has ~200 posts. It feels good to see lots research and authority gained over the time. It is lot smaller time frame compared to my Ph.D. You are always told it takes 3-4 years to see any conversion. People having no tech knowledge are making a good income. I am learning SEO and WP management in my spare time to help myself. It is addictive.
2. InboxDollars – InboxDollars is similar to Swagbucks, since you're going to be taking surveys, shopping, etc., so if you want to maximize your return, sign up with both websites. They also offer a search engine that pays you (like Swagbucks) and you get $5 just for signing up. I won't continue to list survey sites one after another down the list, but if you want to get paid to take surveys, also check out GlobalTestMarket, E-Poll Surveys and Survey Club.
There is no misinformation outlined in this step, but so much about the process of building an internet marketing site is left out. It's not dishonest, but it is deceiving. Even if you progress through their free course, you'll still only possess the basics of the basics. To have any hope of knowing what to do with your site you'll absolutely have to go premium and be prepared to spend tons of hours learning and asking questions.
Rose and others looking for employment this summer: Retry the babysitting idea. Summer is a good time to babysit. Maybe volunteer a few times first and then use those families as references. Tell everyone you know that you are available to babysit. Use email, Facebook, fliers, word of mouth. Also try offering a set time every week, like Tuesday evenings form 5-9 pm in your home. Parents know they can drop off their children without calling ahead. They really appreciate that. It takes time and persistence to get the word out, butit can be done!
Referral fees aren't just for the products you recommend. Perhaps the coolest thing about the Amazon Associates program is that you receive credit for any sale associated with your affiliate link for 24 hours. So, if a customer visits the page of the product you recommended, but then goes on to purchase five more eligible items during that same visit, you will receive a portion of that entire sale.
Set up a website. Professional or business websites can also use the Affiliate program. However, they are best used with people who do not sell similar products on their website, since Amazon's marketplace can drive business away. If you have a website promoting different products, a club, a non-profit or a service, then you can recommend quality products on your site and make money doing it.
This is a fantastic article and it really has given me help. I want to go to this thing in the summer called Creation Fest and it has music and speackers to celebrate God and it costs a lot! I was looking for help and I found this. $100+ seems easy at first but then your stuck when your my age. Thanks a whole bunch and I will probably come back again.
It was a bit of fun fo a while Marcus but I must admit that I got bored with "The Community" and deliberately engineered my ejection from it. The whole process took a matter of minutes after I got into a live chat and dared them to chuck me out. It was then that I had my wrist slapped for disrespecting a so called "Ambassador". What a joke! I stated that I have no respect for authority in the real world so that little group meant nothing to me and I would say whatever I like. Didn't take long for one of them to report me to their god and I then got an on screen message to inform me that Admin had revoked my write access. Really did me a favour as I don't think it would've taken long for real insults to start flying. Some of the long term members there seem to be badly infected with the WA bug and have serious delusions of grandeur. I noticed that a lot have psychological problems and other illnesses which prevent them from having a "proper job" and are not shy to share their personal problems with fellow members.
Promoting WA is one of the most crowded and competitive niches one could hope to tackle, and yes, even if someone did manage to rise above the rest, it would likely take 12-18 months or more. And even then, you'd still be outranked by most of WA's other website properties and social media profiles. BY promoting the WA Bootcamp so aggressively, WA is able to bolster its authority even further by facilitating so many inbound links coming from sites indexed for their keywords.
2 - This is not just for beginners on the internet. There are a large amount of marketers that joined to learn more and love it. So the coaxing part you mentioned.... not really there. You can stay a free member but you just don't get the info that premium members get. You seemed to be outraged about that. Well how about you give your services away to anyone that does not want to pay and then charge the ones that think it's worth it. How soon before you are called out and you have no business at all. So that complaint is just non-sense.


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Let's take a look at the Quarterback situations heading into training camp for each of the 32 teams. Below are our rankings...
Lightning in the area suspends the game and field of play must be vacated. 11:43 left in the game #BALvsPHI
Preseason = Flag Football at its finest 😡🤯
#EnoughAlready https://t.co/I8v0cRMbEw
Josh McCown impressive for just 4 days in camp!
17-24 for 192 and 2 TDs. https://t.co/OLogLCFwZH

subset: commoncrawl


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Irish authorities place Quinn Insurance into administration
The Irish financial regulatory authorities have today placed Quinn Insurance Ltd, one of Ireland's largest insurance companies, into administration amid unclear matters which have come to light after an investigation of the company. However, the company, founded by one of Ireland's richest investors Sean Quinn, believes it could have corrected the mystery issues without being placed into administration.
Quinn Insurance Ltd today claimed to be making around $27 million a month in profits although it is unclear why the regulator would act so swiftly if the company appeared to be in such good health. No doubt we will hear more rumours and counter rumours in the days and weeks ahead and while the authorities are looking to secure and firm up the financial sector, on the face of it there looks to be more short-term pain ahead but hopefully long-term gain.
This is yet another blow for the Irish financial sector which has become a very difficult place in which to trade over the last few months. Indeed the Irish authorities are looking to step in to take over a significant chunk of the market with an announcement expected at 5 PM hopefully clarifying the situation regarding the overall market.
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B12: Like folic acid, B12 is essential for healthy nervous system development and function. Pregnant women who are vegans or vegetarians may fall short on B12, since it is present in animal protein and to a lesser extent in dairy. Teenage and adult women need 2.4 mcg. Recommended levels rise to 2.6 mcg for pregnant women and 2.8 mcg for lactating women.
When trying to adopt new healthy habits, it's important to work around other long-standing practices that could sabotage your efforts if overlooked. For example, if you are a morning person, working out in the a.m. is likely best, but if you're a night person, exercise after work, says Tara Stiles, owner of Strala Yoga in New York City. [Tweet at Tara!]"Don't try to become one or the other if it's not natural to you. You're more likely to stick to it if you like the time of day and the whole experience."
Getting enough water also is important. Many experts recommend at least eight 8-ounce glasses of water daily—more if you exercise frequently or are exposed to extremes of heat and cold. The 2010 Dietary Guidelines for Americans emphasize drinking more water and other calorie-free beverages, along with fat-free or low-fat milk and 100 percent fruit juices, instead of calorie-packed regular sodas.
It has not been scientifically established that large amounts of vitamins and minerals or dietary supplements help prevent or treat health problems or slow the aging process. Daily multivitamin tablets can be beneficial to some people who do not consume a balanced diet or a variety of foods. Generally, eating a well-balanced diet with a variety of foods provides the necessary nutrients your body needs. Eating whole foods is preferable to supplements because foods provide dietary fiber and other nutritional benefits that supplements do not. If you choose to take vitamin and mineral supplements, it is recommended to choose a multi-vitamin that does not exceed 100 percent of the Recommended Dietary Intake (RDI).
A well-balanced diet, comprised of a variety of foods, adequately meets women's needs for vitamins, minerals and energy. For good health, women need to pay special attention to calcium, iron and folate (folic acid) intake. A healthy diet also should minimize the intake of fat and sugar. Diets high in saturated or trans fat can promote high levels of blood cholesterol and increase risk for heart disease. A diet that includes high sugar provides empty calories, or calories that do not provide any nutritional value and often times replace more nutritious food selections.
B12: Like folic acid, B12 is essential for healthy nervous system development and function. Pregnant women who are vegans or vegetarians may fall short on B12, since it is present in animal protein and to a lesser extent in dairy. Teenage and adult women need 2.4 mcg. Recommended levels rise to 2.6 mcg for pregnant women and 2.8 mcg for lactating women.
Frankly, looking around, it seems your choice is either a magazine that barely addresses fitness, or going straight to the hardcore muscle-building mags. I was hoping for something reasonably in-between with Women's Health, but failed to find it. If someone knows of such a magazine, I'd be interested to hear it (I tried Women's Fitness, which suffers from the same problems as Women's Health). The good news is that my subscription to Women's Health seemed to get me a good price on Men's Health, which I am switching over to because some reviewers recommended it for those disappointed with the content of WH. I'll see how that works out.
I realize that none of the above foods have 100% DV of calcium, and while we all should be getting a variety of these foods through the week to help increase the amount of calcium from whole foods, you can also boost it with a supplement- especially if you fall into any of the above categories. I've really been liking the New Chapter's Every Woman's One Daily Multivitamin which has calcium and is rich in vitamin D3. Read more on that in the next question!
It takes a lot of discipline to turn down a cupcake or roll out of your warm bed for a cold morning run. To make staying on track easier, it's important to make a real connection with your motivation, says Tara Gidus, R.D., co-host of Emotional Mojo. So think less about fitting into your skinny jeans or spring break bikini and more about emotional ties to the people you love. "Your relationships will grow stronger when you are physically healthy and taking care of yourself," she says.
No matter how busy you are, eat lunch before 3 p.m., a Spanish study suggests. Researchers placed a group of women on a diet for 20 weeks; half ate lunch before 3 and half consumed their midday meal after 3. Although both groups' daily caloric intake, time spent exercising and sleeping, and appetite hormone levels were the same, those who lunched late lost about 25 percent less weight than earlier eaters. Being European, lunch was the biggest meal of the day for these women, constituting 40 percent of their calories for the day, so consider slimming down dinner in addition to watching the clock.
Nutrition interventions that target mothers alone inadequately address women's needs across their lives: during adolescence, pre-conception, and in later years of life. They also fail to capture nulliparous women. The extent to which nutrition interventions effectively reach women throughout the life course is not well-documented. In this comprehensive narrative review, we summarized the impact and delivery platforms of nutrition-specific and nutrition-sensitive interventions targeting adolescent girls, women of reproductive age (non-pregnant, non-lactating), pregnant and lactating women, women with young children<5 years, and older women, with a focus on nutrition interventions delivered in low- and middle-income countries. We found that though there were many effective interventions that targeted women's nutrition, they largely targeted women who were pregnant and lactating or with young children. There were major gaps in the targeting of interventions to older women. For the delivery platforms, community-based settings, compared to facility-based settings, more equitably reached women across the life course, including adolescents, women of reproductive age, and older women. Nutrition-sensitive approaches were more often delivered in community-based settings, however, the evidence of their impact on women's nutritional outcomes was less clear. We also found major research and programming gaps targeting overweight, obesity, and non-communicable disease. We conclude that focused efforts on women during pregnancy and in the first couple of years postpartum fails to address the interrelation and compounding nature of nutritional disadvantages that are perpetuated across many women's lives. In order for policies and interventions to more effectively address inequities faced by women, and not only women as mothers, it is essential that they reflect how, when, and where to engage with women across the life course.
The trick to biking uphill is to look ahead and anticipate. "Try to plan for what's coming," says Georgia Gould, a LUNA pro athlete and 2012 Olympic bronze medalist in women's mountain biking. "Start shifting down one gear at a time for a smooth, energy-saving transition. Ideally your cadence should stay the same as you transition from harder to easier gears."
Always be sure you get regular servings of dairy products, calcium-rich tofu and greens, and calcium-fortified orange juice. Also, eat lean meat and/or high-quality protein combinations such as pinto beans and rice. Avoid fiber supplements as these bind calcium and other minerals in the intestinal tract. When this happens the absorption of essential nutrients decreases.
In the past, women have often tried to make up deficits in their diet though the use of vitamins and supplements. However, while supplements can be a useful safeguard against occasional nutrient shortfalls, they can't compensate for an unbalanced or unhealthy diet. To ensure you get all the nutrients you need from the food you eat, try to aim for a diet rich in fruit, vegetables, quality protein, healthy fats, and low in processed, fried, and sugary foods.


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Berlin: Everton forward Ademola Lookman has joined RB Leipzig on a five-year contract, the two clubs announced on Thursday, in a deal worth a reported £22.5 million ($28 million).
Lookman, 21, spent the second half of the 2017/18 campaign on loan at the Bundesliga club, registering five goals and four assists in 11 league appearances, but returned to Goodison Park last season.
The England Under-21 international joined Everton from Charlton in 2017, scoring four goals in 48 matches for the club.
He played 24 times in all competitions for manager Marco Silva last season, starting six games and scoring once.
"I'm very happy to be back here and would like to continue where I left off in the second half of 2018 for RB Leipzig," Lookman told the club's website.
"Of course, I'm also looking forward to seeing my teammates again and would like to help the team to continue to celebrate great successes."
Updated Date: Jul 25, 2019 16:02:14 IST


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In 2015, Rachel and Ruby started being Shelf, a comedy double act. A lot has changed since then. Shelf offer a "winning hybrid of sketch show and standup" (Edfringe Review) that has been said to "find belly laughs in heavyweight topics such as gender, sexuality and mental health" (Diva Magazine).
Since their formation, Shelf have performed at Bestival, London Pride, and been nominated for Sketchfest's Best New Act award. Their work has appeared on BBC3 and LADBible. They are founding members of sell out monthly night The LOL Word, which showcases queer women and non-binary comedians from across the London comedy circuit. They are board members of the cult hit Alternative Comedy Memorial Society, with whom they regularly perform in London and Edinburgh.


text: Color Block: Mexico City's Bold Fashion The vibrant hues of Mexico City act as the backdrop for model Emily DiDonato's dramatic wardrobe palette of black and white. Photography by Angelo Pennetta for WSJ. Magazine, Styling by George Cortina Sept. 29, 2014 11:47 am ET ... To Read the Full Story Subscribe Sign In Most Popular Videos What Falling Interest Rates Mean for You Flipping for Profit: Meet the Couple Making Six Figures by Reselling Kashmir on Edge as Lockdown Paralyzes the Region How to Track People With Find My Friends, Google Maps and Life360 Clashes at Hong Kong Airport Reveal Weakness of Leaderless Movement Most Popular Articles An Economic Warning Sign: RV Shipments Are Slipping Opinion: Trump Isn't the One Dividing Us by Race Russian Nuclear Monitoring Stations Went Silent After Missile Blast Opinion: California's Biggest Cities Confront a 'Defecation Crisis' Trump Calls for a Big Fed Rate Cut, Again Criticizes Powell


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With the advent of 5G, we're entering the new era of always-connected laptops. However, 5G isn't exactly here yet – not as here as it needs to be – and so companies are ramping up the always-connected angle with the prevalent 4G connectivity that we have today. Samsung's Galaxy Book …Read More »
Huawei rumoured to be using a 90Hz display in the upcoming Mate 30 Pro
Much has been made of Huawei's plight in recent times and its future is uncertain but one thing for sure is, they are going to continue to make some great hardware. The Mate 30 Pro is set to be a prime example of this according to the latest rumours. Chinese …Read More »
Huawei's Mate X has been delayed, company citing "cautious approach"
In another week of good news for Huawei, the Chinese company has been forced to delay the launch of its Mate X foldable handset which was originally to be launched next month. The Chinese tech giant told CNBC and The Wall Street Journal that it was doing extensive testing to …Read More »
Telstra More Than Doubling Sydney 5G Coverage June 30th 2019
When Telstra first launched 5G services in Australia 2 weeks ago, Sydney had very little coverage and none of it covered the CBD. That all changes by June 30th 2019 when Telstra lights up more 5G towers across the country. The difference will be especially obvious to early Sydney based …Read More »
Initial Telstra 5G Rollout Works Better Outside than Inside
Amongst all the excitement about 5G being launched in Australia an important detail has been missed. During the early first year or two of the Telstra 5G rollout, if not for longer, 5G will work much better outdoors than inside. 5G uses different spectrum and broadcast tower technology to 4G. …Read More »
ICYMI: Ookla 5G map now shows pre-release towers in testing
In the middle of last month, Ookla – The company behind Speedtest – released a 5G availability map which is a useful tool to users wondering if they're going to see benefit from upgrading. There's further good news (in part at least) that they have now added "pre-release" towers to …Read More »
Samsung Galaxy Note 10 CAD renders leak revealing punch hole display and NO Bixby button
The Galaxy Note10 will be Samsung's next flagship phone to be released, most likely at the beginning of August. Overnight @onleaks and 91mobiles have renders of the Galaxy Note10 that they have obtained. CAD renders are renders of the phone usually made based on measurements and details provided to case …Read More »
Google releases Android Q Beta 4 for Pixel phones: here's what's new
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Two different Samsung Note10 variants appear on Geekbench, one sporting 12GB of RAM
Come mid-year the H1 flagship races have all been run and done and eyes turn to the next race — the H2 flagships. Of the few phones that are released in the second half of the year one of the more significant and one that garners a lot of the …Read More »
LG's V50 5G comes to Telstra June 11, and it's bringing the second screen too
We went into Mobile World Congress expecting a bevy of similar-looking phones, and came out surprised and enthused by LG's V50 ThinQ with its second touchscreen. Fast forward a couple of months and the phone is ready to launch with Telstra on their nascent 5G network (and the company's excellent …Read More »
OPPO launches Reno 5G and Reno 10x Zoom in Australia, coming June 11 from $1199
This afternoon Oppo has announced two phones – the Reno 5G and the Reno 10x Zoom – for release in Australia. The comnpany is especially proud to be launching on Telstra's just-opened 5G network. The third such device, Reno 5G is set to make a big splash in the Australian …Read More »
Mediatek looking to power affordable 5G devices with a new chip with integrated 5G modem
5G may well be the future but it seems that all 5G phones, for the foreseeable future will be expensive and out of the reach of many people. Chinese chip manufacturer Mediatek, known for affordable chipsets, is hoping to corner this market with a new processor with inbuilt 5G modem …Read More »
Project Limitless: Qualcomm and Lenovo unveil world's first 5G PC powered by Snapdragon 8cx processor
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Telstra 5G is ready to go with Samsung's Galaxy S10 5G and HTC's 5G Hub available starting tomorrow
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Samsung announces the Australian availability of its first 5G phone, the Galaxy S10 5G
Samsung announced the Galaxy S10 lineup just prior to MWC and we heard about a 5G variant in the works from Telstra themselves. Now, three months later, it is primed for release into the Australian market – from next week. The Samsung Galaxy S10 5G is an upgrade over their …Read More »


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592 self catering cottage letting's in South East England. Rent superb cottage accommodation and holiday rentals with features such as hot tubs, sauna's, gyms, heated swimming pools and much more! Refine your search of self catering accommodation to let in South East England by using the county and region menus on the left.
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Sleeps 4
Weekly prices from £404
to £ 771
Self catering accommodation in Hooe sleeps 4.
Features include: • Garden • Pub near by • Short Breaks • Games Room • Detached Property • Cottage Sleeps 4
Accommodation overview: This converted single-storey detached holiday barn with two shower rooms lies adjacent to the owners' and is beautifully presented and enjoys far reaching views. The village of Hooe was once surrounded by sea although 2 miles from the coast now, it is possible that William the Conqueror landed here. The remoteness of the area and distance to the sea made this an ideal smuggling haunt and the landlord of the Red Lion, James Blackman, was a member of the Groombridge Gang in the 18th century. Pevensey Levels are an ornithologist's and walker's delight. Pevensey is one of the south's leading locations for windsurfing and water sports. Battle takes its name from the 1066 battle, and was once home to one of the country's largest gunpowder works. Shop 1 mile, pub ½ mile.
Living/dining room with wooden floor and French doors/kitchen. Twin bedroom with en-suite shower room and toilet with slate floor. Two steps up to double bedroom. Shower room with toilet and slate floor.
Sleeps 2
Weekly prices from £274
Self catering accommodation in Ewhurst Green sleeps 2.
Features include: • Internet Access • Cottage Sleeps 2
Accommodation overview:
Coach House Barn is a beautifully converted former cowshed with a wealth of beams, high ceilings and wooden floors. Occupying a quiet corner of a 30 acre estate some distance from a little-used country lane, the barn has a wonderful tranquil setting and enjoys panoramic views over the surrounding fields and wooded hills. With a footpath at the end of the garden linking to an extensive network of walks, the property provides a perfect base from which to explore this AONB. The beautiful village of Ewhurst Green is approximately a mile by road or three-quarters of a mile by footpath. A mile away across the pretty river Rother lies the historic 13th century Bodiam Castle. Bateman's, Scotney Castle and Sissinghurst are also nearby. Gardens to visit include Great Dixter, Pashley Manor and Merriments. Further afield is the quaint town of Battle with its famous Abbey and battlefield and the historic port of Rye is just 9 miles with the glorious dunes and fabulous beach at Camber Sands just a little further along coast.
Sleeps 2
Weekly prices from £315
to £ 611
Self catering accommodation in Crowborough sleeps 2.
Features include: • Garden • Pet friendly • Swimming Pool • Pub near by • Short Breaks • Games Room • Detached Property • Cottage Sleeps 2
Accommodation overview: Converted to a high standard, this attractive holiday cottage resides within 60 acres of woodland and fields with abundant wildlife and is accessed via a mile long track. Single-storeyed and detached, it makes an ideal base for fishing (with access to carp ponds) and walking within the High Weald, an AONB. Royal Tunbridge Wells is 7 miles, Groombridge Place Gardens and the Enchanted Forest 5 miles and the Bluebell Railway 7 miles. Easy access to London by train (about an hour). Riding, rock climbing and golf locally. Motorbikes are welcome. Shop and pub 1 mile.
Step up to spacious living/dining room with gas 'wood burner', oak floor and two sets of French doors to decked balcony. Kitchen. Double bedroom with 6ft zip & link bed. Bathroom with over-bath shower and toilet.
Sleeps 12
Weekly prices from £876
to £ 2382
Self catering accommodation in Kirdford sleeps 12.
Features include: • Open Fire or Woodburning Stove • Pub near by • Short Breaks • Games Room • Detached Property • Cottage Sleeps 12
Accommodation overview: In a tranquil setting and surrounded by open countryside and woodland, this secluded detached Victorian house enjoys delightful views over a lake and pastureland. Ideal as a holiday home for an extended family (or two families holidaying together), there is much to see and do in this scenic area of Sussex.The house has a sunny south facing terrace and substantial garden. In addition guests will enjoy the use of 15 acres of secluded bluebell woods and pasture leading to a 1-acre lake. Nearer the house there is a smaller lake in a woodland setting where coarse fishing is available. The property has access to an extensive network of footpaths through this unspoilt part of the low weald rich in animals, birds and plant life.The pretty village of Kirdford has a shop, pub and restaurant and there are numerous country pubs in local villages. The quaint town of Petworth (4 miles) is famous for its stately home, Capability Brown park and antique shops. The charming small town of Midhurst as well as Billingshurst and Haslemere are all within 20 minutes' drive and have good restaurants and more extensive shopping. Motor racing and horse racing are nearby at Goodwood. Leornardslee and West Dean Gardens, Parham House, the Weald and Downland museum and the South Downs themselves are all close. Chichester (½ hour) has its ancient cathedral, festival theatre, Roman ruins, harbour tours and tearooms. At Arundel the castle and Wildfowl Trust are popular. Wittering and other beaches are half an hour away and there is polo at Midhurst and numerous golf courses within easy reach. Shops 3/4 mile.
Entrance hall. Spacious living room with wood-burning stove and French doors to patio. Dining room with open fire and French doors to patio. Spacious well-equipped fitted kitchen with Rayburn, electric cooker and tiled floor. Study area with sofa-bed (for +1). Small utility area. Twin bedroom with en-suite bathroom with over-bath power shower and toilet. Bathroom and toilet. First floor: (accessed by two separate staircases) Two double bedrooms, one with en-suite bathroom with shower attachment and toilet. Area for Z-bed/cot. Two twin bedrooms.
Sleeps 6
Weekly prices from £510
to £ 986
Self catering accommodation in Buxted sleeps 6.
Features include: • Open Fire or Woodburning Stove • Pub near by • Short Breaks • Detached Property • Cottage Sleeps 6
Accommodation overview: Set in its own large garden and with an original bread oven in the kitchen this delightful 16th century beamed spacious and very comfortable farmhouse sits 100 yards from a village shop and pubs. With lovely walking riding and golf in the Ashdown Forest nearby it is an easy drive to Scotney Castle Sissinghurst Gardens Battle Abbey Bewel Water for bird watching fishing and cruises and the coast. London is 40 minutes by train (station 4 minutes' walk). Shop and pub 100 yards.
Ground floor: Living room. Dining room. Kitchen. Study. Separate toilet. Steep stairs to first floor: 3 bedrooms: 2 double one with en-suite bathroom and toilet 1 twin. Bathroom with toilet.
Phone enquiries: 0345 498 6152
Sleeps 2
Weekly prices from £300
to £ 497
Self catering accommodation in Ninfield sleeps 2.
Features include: • Short Breaks • Games Room • Detached Property • Cottage Sleeps 2
Accommodation overview: Situated in the owners' grounds on a 16th-century Grade II listed site, these well-appointed, beamed holiday cottages (PCCX and PCCY) occupy a truly peaceful setting. Located amidst 1066 countryside and ancient woodlands, this was once part of the Ashburnham family estate. Combe Hill Farm is ideally placed for visiting many NT and English Heritage sites, including Batemans - home of Rudyard Kipling, Battle Abbey and Bodiam Castle. The famous Glyndebourne Festival takes place from May to August and the ancient town of Lewes celebrates Bonfire Night with a magnificent procession and firework display. Hastings, with old fishermen's huts and fresh fish, is worth a visit, as is the cobbled town of Rye and beautiful golden sand and dunes of Camber which await exploration. Shop and pub 1 mile.
Sleeps 5
Weekly prices from £346
Self catering accommodation in St Catherines Lighthouse sleeps 5.
Features include: • Garden • Pet friendly • Romantic Breaks • Close to the Beach • Close to the Sea • Pub near by • Cottage Sleeps 5
In association with Trinity House, Rural Retreats are pleased to present St Catherine's Lighthouse in Niton, the Isle of Wight. St Catherine's Lighthouse is situated just outside the hamlet of Niton, approximately 10 minutes' drive from the popular coastal resort of Ventnor, the southern most point of the Isle of Wight. The site comprises a terrace of three self catering, former lighthouse keepers cottages, Landward Cottage, Gurnard and Penda.
There are guided tours of the lighthouse throughout the year (subject to availability). If you would like to view the lighthouse please visit http://www.trinityhouse.co.uk/lighthouses/visitor-centres.html or telephone 01983 730435.
The Lighthouse grounds are enclosed with a wall but young children should be supervised at all times. There is an excellent real ale pub a 10-minute walk up the hill. Each holiday cottage has a private enclosed courtyard and parking area. Beyond the courtyard there is a communal grass area where children can play. Holiday guests can unload in the parking area adjacent to Penda Cottage.
The lighthouse does not have a fog signal.
Access roads to some of the lighthouse sites are narrow with limited passing places and, dependent on the season and site, there is the possibility of overhanging vegetation due to cutting restrictions during bird breeding seasons or other environmental reasons.
Guests should be aware that the lighthouses and equipment need regular and sometimes emergency maintenance. Therefore visits by maintenance staff may occur at any time during the year. However, staff will do their best to ensure guest privacy at all times.
Sleeps 2
Weekly prices from £284
to £ 502
Self catering accommodation in Edenbridge sleeps 2.
Features include: • Golf near by • Short Breaks • Games Room • Cottage Sleeps 2
Accommodation overview: Sympathetically converted and renovated to a high standard, these two adjoining listed barns are situated in beautiful countryside on the owner's 10-acre farm. The interiors boast exposed oak beams and oak floors, as well as a staircase with subtle lighting and latch doors, which all add to the ambience of the properties. In the grounds are two well-stocked lakes, where coarse fishing is available by arrangement with the owner. The cottages are ideally placed for visiting NT properties Wakehurst Place, Sheffield Park, Standen (home of William Morris), as well as Chartwell, Chiddingstone, Hever Castle and Penshurst Place. Hartfield Village is 31/2 miles for A.A. Milne's Pooh Bridge, and Tunbridge Wells for its famous Pantiles and spa. Racing at Lingfield offers a pleasant way to spend an afternoon or evening, whilst there is sailing at Bough Beech Reservoir and bird lovers will enjoy seeing migrating ospreys at the adjacent nature reserve. Excellent walking in Ashdown Forest. Golf locally. Shops 3½ miles.
Sleeps 4
Weekly prices from £326
Self catering accommodation in Amberley sleeps 4.
Features include: • Internet Access • Open Fire or Woodburning Stove • Romantic Breaks • Close to the Beach • Pub near by • Cottage Sleeps 4
Densford Cottage is a terraced cottage situated in the picturesque conservation village of Amberley, which is regarded as one of the most beautiful villages in England. Situated in an Area of Outstanding Natural Beauty at the foot of the South Downs, it lies within the newly created South Downs National Park.
The village has wonderful views of the Amberley Wildbrooks nature reserve, a Site of Special Scientific Interest on the flood plain of the River Arun, where cattle graze amongst the migrating birds.Amberley has many historic buildings and thatched cottages and it is just a three minute walk to the 900 year old church which adjoins the 11th century Amberley Castle which is now a renowned hotel set in stunning grounds with superb dining (booking is advised). The village also has a tearoom (seasonal), a pottery and local shop with a post office.There are two local pubs within a three minute drive.
Just outside the village is the Amberley Museum and Heritage Centre. It is a 36 acre open air site dedicated to the industrial heritage of the South East and has a restaurant. Parham Park is a two mile drive from Amberley. This 16th century manor house has lovely gardens and is surrounded by over 800 acres of woods and deer parkland. It is open to the public during the spring and summer months and there is a public footpath through the park.
The historic town of Arundel is just a 10 minute drive. Arundel Castle is the seat of the Dukes of Norfolk and has an attractive Italianate Garden. There are many antique shops, cafes and restaurants, a Wildlife and Wetland Centre and there are boat trips along the River Arun. The cathedral city of Chichester is also nearby and the Festival Theatre and Pallant Art Gallery are close to the centre. Goodwood, with its racecourse and motoring events, is also within easy access.
The Blue Flag sandy beach at West Wittering is a 20 minute drive and offers wonderful views of Chichester harbour. Sailing enthusiasts can hire boats around the harbour. A railway station serves the village of Amberley from which it is a 10 minute walk to the cottage. There are good train services from London Victoria.
Guest Note: The pond in the garden is unfenced and there is also a drop behind the wall at the end of the garden - small children must be supervised.
Sleeps 2
Weekly prices from £320
to £ 859
Self catering accommodation in Shanklin sleeps 2.
Features include: • Garden • Pet friendly • Open Fire or Woodburning Stove • Games Room • Cottage Sleeps 2
Accommodation overview: This attractive, thatched, detached holiday cottage, restored and refurbished throughout, is peacefully set amidst extensive gardens, and offers splendid views over the sea. Nestled within glorious Luccombe Chine, where numerous public footpaths abound, and leading to scenic woodland and countryside walks along Heritage coastline. The quaint village of Bonchurch is just over a mile, with unspoilt beach, P.O.shop and bistro. The seaside resorts of Ventnor and Shanklin are both about 2 miles. There is so much to do on this lovely temperate isle: discover NT homes and gardens, wildlife parks, waterside restaurants serving fresh fish of the day, and various outdoor pursuits. Shops and pub 2 miles.
Living room with sofa bed (alternative sleeping only) and stable door to garden. Dining room with open fire. Kitchen with butler sink, flagstone floor and stable door to garden. Double bedroom with stable door to garden and two steps down to en-suite bathroom with shower attachment and toilet.
Sleeps 10
Weekly prices from £989
Self catering accommodation in Ventnor sleeps 10.
Features include: • Garden • Pet friendly • Internet Access • Close to the Beach • Golf near by • Pub near by • Cottage Sleeps 10
The Haven is a luxuriously appointed, detached holiday house located in the south of the Isle of Wight within an area known for its Mediterranean-style climate and areas of natural beauty.
There is plenty to see and do in the Isle of Wight. The secluded Steephill Cove is a five minute stroll away, and the Ventnor Botanical Gardens with a modern visitor centre, incorporating regular local art displays and exhibitions, is just a couple of minutes' walk away. The gardens also have a restaurant and a children's play park. An ideal location for an outdoor break, the Isle of Wight coastal path walks are within a minute's walk of the Haven.
Ventnor seafront offers various places to eat, a popular beach which is good for sunbathing and swimming, a selection of shops and amusements, and plenty of car parking.
The luxury self catering rental can accommodate 10 guests, using the two full height pull-out beds in the twin bedroom.
Sleeps 5
Weekly prices from £415
to £ 898
Self catering accommodation in Iden sleeps 5.
Features include: • Open Fire or Woodburning Stove • Fishing near by • Short Breaks • Games Room • Detached Property • Cottage Sleeps 5
Accommodation overview: Situated on the Royal Military Canal and beside Iden Lock, The Lock Cottage dates back to the Napoleonic era, when it was used as officers' quarters. The lock itself was completed in 1808 whilst this detached, single-storey holiday cottage was built in 1824. Iden Lock is no longer a working lock; the last barge passed through it in 1909, the receipt for which was signed by Spencer Catt who had been the lock keeper since 1890. He was the great great great grandfather of The Lock Cottage's current owner. Guests can paddle their canoe from Iden Lock to West Hythe or hire rowing boats at Hythe. Fishing and walking available. Camber Sands 5 miles. Rye, Appledore and shops 3 miles.
Living room with oak floor. Dining room with open fire. Kitchen with butler sink and tiled floor. Two double bedrooms, one with wood-burning stove, one with ornamental fireplace. Single bedroom with ornamental fireplace. Step up to bathroom with shower over corner bath, toilet and tiled floor.


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teamba needed a new logo design and created a contest on 99designs.
A winner was selected from 211 designs submitted by 55 freelance designers.
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Exercise physiology, strength and conditioning coach, prehab and rehab. Target audience: white collar workers, amateur and professional athletes.
I'd like to explore the following colors:
Aquas: Empathy, compassion, clarity and precision.
Light neutrals: Purity, balance and sophistication.
Let designers make suggestions:
We are looking at possibly keeping our current logo, however would like a more condensed version, for example something that contains just the b and the a for use on merchandise, marketing etc. However, if anyone can come up with any improvements for the logo that would be great. We like simple, clean designs. In particular: http://www.bodytech.com.br/. Copy of our current logo is attached.
Find out how a design contest works or learn more about our logo design services.


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Dominic Thiem beats Roger Federer to reach Stuttgart final after saving two match points in the second set
Dominic Thiem rallied from one set down to beat Roger Federer 3-6 7-6 (9-7) 6-4 after saving two match points in the tie-break of the second set. Thiem saved four break points before breaking Federer in the seventh game of the third set.
Federer capitalized on his only break point chance of the first set in the fourth game as Thiem was serving at 1-2. In the seventh game Thiem rallied from 0-30 on Federer's serve to earn a break point. Federer saved the break point to extend his lead to 5-2 before holding his service game to clinch the first set 6-3.
Thiem converted his first break point chance in the second game to take a 2-0 lead. The Austrian player, semifinalist at the Roland Garros, got the double break in the fourth game to open up a 4-0 lead.
Federer got one break back in the seventh game to rally from 0-5 down to 2-5. Federer got the double break in the ninth game for 4-5 as Thiem made a pair of double faults and two unforced errors.
In the 10th game Thiem recovered from 0-40 to 30-40 but Federer held his service game with a service winner to draw level to 5-5. The second set came down to the tie-break.
Federer earned a match point at 6-5 in the tie-break but missed a volley. Thiem saved a second match point at 7-6 with a passing shot winner. Thiem earned a set point as Federer missed a drop shot with an overhead winner.
The match was interrupted immediately due to rain after the end of the second set. After the match resumed, Federer faced a break point in the first game but held his serve. Thiem had to save two break points in the second game. Thiem broke serve to 30 in the seventh game with a passing shot to take a 4-3 lead before another shower forced organizers to stop the match briefly after the seventh game. The young Austrian star held his next two service games to wrap up the match.
Federer and Thiem met for the third time this season. Thiem now leads 2-1 in his three head-to-head matches against Federer. Last January Federer beat Thiem in the semifinal in Brisbane. Thiem beat Federer 7-6 6-4 in their previous head-to-head in the third round at the Rome Masters 1000 Tournament.
Thiem has qualified for his first final on grass. The current world number 7 player will play in his first final as top-10 player.He will face the winner of the second semifinal between Juan Martin Del Potro and Phillip Kohlschreiber.
Thiem has an impressive win-loss record of 44-11 this year. He will be bidding to win his fourth title this season after Buenos Aires, Acapulco and Nice. He lost the Roland Garros semifinal against Novak Djokovic.
Richard Gasquet reaches his first Masters 1000 semifinal since Miami 2013
Frenchman Richard Gasquet edged past this year's Wimbledon semifinalist Roberto Bautista Agut 7-6 (7-2) 3-6 6-2 after 2 hours and 12 minutes to reach his first Masters 1000 semifinal since the 2013 Miami Open.
Gasquet missed six months of action after undergoing groin surgery last January.
The French player set up a semfinal against David Goffin, who reached the semifinal after his Japanese opponent Yoshihito Nishioka withdrew from the match due to illness.
The first set went on serve with no break points en route to the tie-break. Bautista Agut hit a backhand wide at 1-2. Gasquet sealed the tie-break when Bautista Agut hit a forehand long.
Bautista Agut earned two breaks of serve in the second set and sealed it, when Gasquet made his third double fault on set point.
Gasquet broke serve with a volley in the third game of the decisive set. The French player went up a double break to race out to 4-1 lead. He saved two break points to hold his serve at deuce before serving out the third set on his first match point.
"I know how tough it was to come back. I know the moments I had at the start of the year, so I just wanted to enjoy, to fight. It is not easy to come back after six months out, but I am here. I am in semis tomorrow",said Gasquet.
Danil Medvedev cruises past Jan-Lennard Struff to set up an all Russian quarter final against Andrey Rublev
Ninth seed Danil Medvedev cruised past Jan-Lennard Struff 6-3 6-1 in 66 minutes to reach the quarter final at the Western and Southern Open in Cincinnati.
Medvedev committed just 12 unforced errors and won 18 of Struff's 25 second serve points.
Medvedev broke twice in the second and eighth games to win the first set 6-2. The young Russian player got two consecutive breaks in the second and fourth games to race out to a 4-0 lead and held his service game at deuce after saving a break point in the fifth game. Struff held his serve to get his first game on the scoreboard, but Medvedev sealed the win on his first match point. The Russian player has improved his head-to-head record to 3-0 againt Struff.
Medvedev has won 11 of his past 13 matches during the North American hard-court season. He has a solid 41-16 record this season. He finished runner in two consecutive finals to Nick Kyrgios at Washington and to Rafael Nadal in Montreal. In the quarter final the Russian star will face his compatriot Andrey Rublev, who upset Roger Federer 6-3 6-4.
Recent Wimbledon semifinalist Roberto Bautista Agut cruised past Miomir Kecmanovic 6-1 6-2 in just under an hour setting up a quarter final against Richard Gasquet, who beat Diego Schwartzman 7-6 (8-6) 6-3.
Japanese qualifier Yoshihito Nishioka beat Australian player Alex De Minaur 7-5 6-4 in 83 minutes with one break in each set. Nishioka rallied from 4-6 down in the tie-break of the first set to edge Adrian Mannarino 7-6 (8-6) 6-2 in 1 hour and 37 minutes.
"It was a great match and I got better as it went on. I am feeling sharp. I am feeling great now and I am looking forward to the quarter finals of a Masters 1000. I have nothing to lose", said Goffin.
Roger Federer Crashes Out Of Cincinnati Masters
The seven-time champion has suffered a blow to his preparations for the US Open.
World No.3 Roger Federer has been knocked out of the Western and Southern Open in Cincinnati after falling in straight sets to Russia's Andrey Rublev.
The 20-time grand slam champion struggled to find his range as he was overwhelmed by his fearless opponent during the 6-3, 6-4, loss. Despite the huge disparity in experience between the two, 21-year-old Rublev managed to dominate the majority of rallies with the help of some heavy hitting. Producing 17 winners to six unforced errors, compared to Federer's tally of 19 and 20.
"I respect him a lot, I respect all the top players a lot, but today when I was going to court I was going there to win." Rublev said during an interview with Amazon Prime.
"I was not going (to the match) to enjoy. I was going to fight, try to win and do my best."
Rublev's shock win saw the underdog outdo the Swiss maestro in almost every area of the match. Winning the most first serves (85% to 63%), second serves (57% to 63) and a bigger majority of points at the net (5/6 to 7/19). Breaking him twice in the opening set and once in the second. The Russian, who is 70th in the world, is the lowest ranked player to defeat Federer on the tour since Thanassi Kokkinakis at the 2018 Miami Open.
The loss leaves a mark on Federer's impressive record in Cincinnati, which he has won a record seven times. It is the first time he has failed to reach the quarter-final stage since losing to Ivo Karlovic in the third round back in 2008.
"He was playing well. I was maybe struggling especially on the offensive, because overall I didn't think I was feeling the ball badly." Federer reflected during his press conference. "It's just, you know, sort of fast-court conditions and when you sometimes then can't rely on that serve to go or on the one-two punch, which I didn't think was excellent today from my side, you need an opponent that maybe lets you get by some tougher moments, but he didn't do that."
"He was super clean. Defense, offense, serving well. Didn't give me anything. He was everywhere. So it was tough for me, but excellent match by him. I was impressed."
Rublev now has a meeting with compatriot Daniil Medvedev in what will be his first quarter-final at Masters level. Medvedev has reached the final of tournaments in Washington and at the Rogers Cup since Wimbledon. He is yet to drop a set this week and brushed aside Jan-Lennard Struff 6-2, 6-1, in his third round match.
"It's going to be an interesting match for Russia." Rublev previewed. "It will be a tough match for me because the way he plays. Nobody likes to play him."
"I lost to him in a Challenger a few years ago, so it's going to be interesting tomorrow." He added.
The latest victory is only Rublev's second over a top five player in his career. His first was against Dominic Thiem at the German Open last month.
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Includes 4 built-in 10 / 100BASE-TX Ethernet ports to connect wired computers to the network.
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National Pub of the Year with trainman on the Pub Forum
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Submitted on Tuesday, 17th July 2018
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Detail Pages
Crocodile Bar, Liverpool Central, Liverpool
19 Harrington Street
Phone: 01512551731
Served areas
Reviews of Crocodile Bar (Average Rating: 6 of 10) see review guidelines
Please Note: This review is over a year old.
Al Bundy left this review about Crocodile Bar
Depending on your mood this one. Narrow bar that opens out a touch at the back. Can be rowdy.
On 11th March 2015
- rating: 6
[User has posted 3325 recommendations about 3244 pubs]
External web links for Crocodile Bar
No known official website for this pub.
- Facebook - The Crocodile And Baby Croc
Pub location see interactive map of local areaLatest updates View all updates for Crocodile Bar, Liverpool
Map location corrected by Alan Hurdle
18th Jul 2018, 10:45
Picture submitted by Graham Coombs approved
17th Jul 2018, 17:27
Picture submitted by Graham Coombs
Pub Details
Pub details supplied by members of this site to the best of their knowledge. Please check with pub directly before making a special trip.
- Karaoke : Yes last updated 26 July 2015 by Dave McNally
- Real Ale : No last updated 09 May 2014 by Dave McNally


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All the films you can watch.£16.95 a month.
Plus 25% off food & drink*
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Market Place Shopping Centre, Bolton, BL1 2AL
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2h 41m
In 1969 Los Angeles, television star Rick Dalton and his longtime stunt double make their way around a changing industry that they hardly recognize anymore.
1h 46m
Determined to keep Annabelle from wreaking more havoc, demonologists Ed and Lorraine Warren bring the possessed doll to the locked artifacts room in their home, placing her "safely" behind sacred glass and enlisting a priest's holy blessing.
1h 27m
When a massive hurricane hits her Florida hometown, Haley ignores evacuation orders to search for her missing father.
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A thrilling and vibrant live-action adaptation of Disney's animated classic, Aladdin is the exciting tale of the charming street rat Aladdin, the courageous and self-determined Princess Jasmine and the Genie who may be the key to their future.
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Having spent most of her life exploring the jungle with her parents, nothing could prepare Dora (Isabela Moner) for her most dangerous adventure ever – High School.
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From Disney Live Action, director Jon Favreau's all-new The Lion King journeys to the African savanna where a future king is born.
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After eight films that have amassed almost $5 billion worldwide, the Fast & Furious franchise now features its first stand-alone vehicle as Dwayne Johnson and Jason Statham reprise their roles as Luke Hobbs and Deckard Shaw.
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When there is an assassination attempt on U.S. President Allan Trumbull (Morgan Freeman), his trusted confidant, Secret Service Agent Mike Banning (Gerard Butler), is wrongfully accused and taken into custody.
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Just how bad can one day get? The creative minds behind Superbad, Pineapple Express and Sausage Party take on sixth grade hard in the outrageous comedy, Good Boys.
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Peter Parker and his friends go on summer holidays to Europe. However, the friends will hardly be able to rest.
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1h 56m
Yesterday, everyone knew The Beatles. Today, only Jack remembers their songs. He's about to become a very big deal.
2h 5m
Beloved British artist L.S. Lowry (Timothy Spall) lived all his life with his over-bearing mother Elizabeth (Vanessa Redgrave). Bed-ridden and bitter, Elizabeth actively tried to dissuade her bachelor son from pursuing his artistic ambitions.
4h 15m
Double bill featuring The Terminator (1984) and Terminator 2: Judgment Day (1992).
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Do guys think I'm unattractive because I am or Is it because I think I'm unattractive?
So usually when I have crushes, I've found them to be really attractive but when I go to tell them that I'm interested I get rejected and they tell me there's other fishes in the sea. So then, I go and doubt myself because if it happens often It's more likely that I'm the problem, not them and then I start to believe I'm not attractive and that me being a colored person might be what guys are not really into since all my past crushes just happened to be white. If they're not attracted to me and I'm having doubts about myself and thinking wow I must actually be ugly if no guys really find me attractive, and I start to hate myself for even trying like I tell myself why do I even try like its just never going to happen (relationship). I think its also because I hate myself and when you're right about things like when you have a crush and then you go and tell them and they don't feel the same way its like it becomes a fact, not a doubt and it just proves something to myself. I don't know if anyone has a disgusting feeling when you try to Flirt with someone like its just a gross feeling that you feel about yourself. I feel like I'm honestly lost and I have no idea what to do any comments at this point will help me, sorry for the long paragraph.
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What Girls & Guys Said24
I'm so sorry that you feel this way. I know that confidence is something that a lot of men find attractive. Maybe if you try to gradually work on that then things will change for you?
if you're going to ask people what they think about how you look you should probably include a picture of yourself so they have something to go off of.
I'd need photos to give my opinion on how attractive you are based on looks.
You can never be with someone, until you can be with yourself..
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It is because you think your unattractive
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Knopp Biosciences Expands Research Collaboration with Cincinnati Children's to Characterize Effect of Dexpramipexole in Inflammatory Diseases
Knopp Biosciences LLC, a privately held drug discovery and development company focused on delivering breakthrough treatments for inflammatory and neurological diseases with a high unmet need, today announced the expansion of its research collaboration with Cincinnati Children's Hospital Medical Center to further elucidate the eosinophil-depleting mechanism of action of Knopp's lead investigational drug, dexpramipexole.
Eosinophils are white-blood cells that play a central role in several debilitating conditions, including asthma, hypereosinophilic syndrome (HES), and other inflammatory diseases. Dexpramipexole has been shown to selectively reduce eosinophil levels in multiple clinical trials, including a Phase 2 study in HES and a Phase 2 trial in chronic rhinosinusitis with nasal polyps . Knopp is advancing dexpramipexole into Phase 2 development in severe asthma and Phase 3 development in HES.
The research at Cincinnati Children's Hospital Medical Center is being led by Patricia C. Fulkerson, M.D., Ph.D., Associate Professor of Pediatrics, University of Cincinnati College of Medicine, and Cincinnati Children's Hospital Medical Center, and a leading authority on eosinophil-mediated diseases. Dr. Fulkerson's lab has developed a number of innovative methods to study the differentiation and maturation of eosinophils. Through a previous collaboration with Knopp, she and her team employed an induced pluripotent stem cell (iPSC) culture system to study the ability of dexpramipexole to inhibit the maturation of eosinophil progenitor cells. Looking forward, Dr. Fulkerson and her team will investigate molecular pathways in eosinophil development and attempt to further elucidate the effect of dexpramipexole on those pathways.
"We are pleased to expand our research collaboration with Dr. Fulkerson to more fully characterize the eosinophil-lowering mechanism of dexpramipexole," said Michael Bozik, M.D., Chief Executive Officer of Knopp. "Dr. Fulkerson's expert knowledge of eosinophil biology and her extensive experience in treating children with eosinophil-associated diseases uniquely position her to lead this collaboration that will inform and support the clinical development of dexpramipexole for the treatment of asthma and HES."
Knopp Biosciences, based in Pittsburgh, PA, is a privately held drug discovery and development company focused on delivering breakthrough treatments for inflammatory and neurological diseases with a high unmet need. Knopp's clinical-stage small molecule, dexpramipexole, is entering Phase 2 development in severe asthma and Phase 3 development in HES. Knopp's preclinical Kv7 platform is directed to small molecule treatments for neonatal epileptic encephalopathy, other rare epilepsies, tinnitus, and neuropathic pain. Please visit www.knoppbio.com .
Forward Looking Statement
This press release contains "forward-looking statements," including statements relating to planned regulatory filings and clinical development programs. All forward-looking statements are based on management's current assumptions and expectations and involve risks, uncertainties and other important factors, specifically including the uncertainties inherent in clinical trials and product development programs, the availability of funding to support continued research and studies, the availability or potential availability of alternative therapies or treatments, the availability of patent protection for the discoveries and strategic alliances, as well as additional factors that may cause Knopp's actual results to differ from our expectations. There can be no assurance that any investigational drug product will be successfully developed or manufactured or that final results of clinical studies will be supportive of regulatory approvals required to market a product. Knopp undertakes no obligation to update or revise any such forward-looking statements, whether as a result of new information, future events or otherwise.
Knopp's pipeline consists of investigational drug products that have not been approved by the U.S. Food and Drug Administration. These investigational drug products are still undergoing clinical study to verify their safety and effectiveness.
View source version on businesswire.com: https://www.businesswire.com/news/home/20190116005285/en/
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Managers Reveal Their Most Difficult Karen-esque Customer Experience
When in doubt.... be a Karen! LOL
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