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Cass Sunstein is among the country's foremost legal scholars, distinguished by both his prodigious output and an interdisciplinary approach that draws on the insights of behavioral psychology, economics, and social science research. In his latest book, Constitutional Personae: Heroes, Soldiers, Minimalists, and Mutes, he gives us an engaging study of jurisprudential comportment that classifies judges into the four groups of the subtitle.
Posner's Unjustified Attack on Scalia
I was saddened to read Judge Richard Posner's vitriolic criticism of Antonin Scalia written in the New York Times with Eric Segall. Judge Posner's scholarship was the most important contribution to law in the latter half of the 20th century. He reformed many areas of law through the application of economics and did so with clarity, wit, and panache. As Blackstone was the leading legal scholar of this time, so was Judge Posner during my first 25 years as a lawyer.
But being a scholar carries some obligations. And one of them in my view is the obligation of charity—to put the views you oppose in the best possible light before critiquing them. Or if that is not possible within the short space of an op-ed, at least not caricaturing them. I would think that also the obligation of one federal judge to another in the popular press.
And it is obvious from his vast body of work that Justice Scalia does not believe in deferring to the majority, when the Constitution actually prohibits what the majority wants to do. He emphatically does not, as the Judge Posner and Professor Segall claim, embrace "the model of the British Constitution" where the legislature once was the final word.
Justice Scalia rigorously enforces the First and Second Amendments in the Constitution and many other provisions as well, including many that defend the rights of unpopular minorities, like those accused of crimes, because they are in the Constitution.
Don't Further Politicize the Court
Rick Hasen has called for making Supreme Court appointments an important part of 2016 political campaign. What is distinctive about his argument is that he drops all pretense of appointing justices based on their jurisprudence or methods of legal analysis. He just wants a series of left-liberal results that he characterizes as civil right decisions, although some of these results, like overruling Citizens United, actually take away civil rights exercised against the majority. He wants to further politicize the Court. He is kind enough to quote me as arguing for depoliticization: The Court should act apolitically by applying the same formal methods in highly contested constitutional cases that it does in garden variety cases, such as the bankruptcy code.
Hasen dismisses this possibility and in particular the most important tool for doing so– originalism. But his arguments are very weak. He observes that at times Scalia and Thomas—both originalists—disagree. But of course no methodology eliminates all disagreement, even if it depoliticizes that disagreement by forcing justices to look at the empirical facts rather than to their preferences. And in any event Scalia and Thomas have some of the highest rates of agreement of any two justices on the Court.
Hasen also argues that terms like equal protection are sufficiently vague to permit alternative legitimate methods of giving effect to the Constitution. But he makes no effort to legitimate or even describe these methods other than to argue that they can help achieve what he views as good political results.
In Defense of Scalia's Style
Justice Antonin Scalia is criticized these days ostensibly not for the substance but for the style of his opinions. His writing is said to be disrespectful as when he critiques the Justice Kennedy's opinion in Obergefell, the recent case on same-sex marriage. There he stated: "If, even as the price to be paid for a fifth vote, I ever joined an opinion for the Court that began: "The Constitution promises liberty to all within its reach, a liberty that includes certain specific rights that allow persons, within a lawful realm, to define and express their identity," I would hide my head in a bag." He also noted: "The Supreme Court of the United States has descended from the disciplined legal reasoning of John Marshall and Joseph Story to the mystical aphorisms of the fortune cookie."
I cannot join in the criticism of his style. That is not to say I particularly warm to the all rhetoric of his dissent in Obergefell. It is not as powerful as that of his masterpiece in Casey, which also had harsh passages, but his disdain has a point. The value of an opinion is measured by the coherence of its reasoning. If someone's opinion is as unreasoned as Kennedy vapidities about identity, it is worth pointing out with some virulence. What John Hart Ely famously said of Roe is true of Obergefell: it is not constitutional law and gives almost no sense of an obligation to try to be.
If Scalia believes (and I think he has reason to believe) that the many of the justices joining in Kennedy's opinion were doing so for its result not for its reasons, they are not acting judicially. Ridicule in defense of the rule of law is no vice.
Ivy Honors and the Justices
Honorary degrees are the highest symbol of recognition that universities can bestow. And the Ivy League retains the greatest reputation for excellence in American higher education. Thus, it is of more than a little interest that these institutions find excellence overwhelmingly in justices on the left of the judiciary.
Of the fourteen honorary degrees bestowed by Ivy League institutions to living Supreme Court justices twelve went to those on the left of the Court. Justice Ginsburg is the champ: she has an honorary degree from every Ivy League university except Cornell and Cornell does not award honorary degrees. And she is by some political science measures the farthest to the left on the Court. Justice Sonia Sotomayor has two such degrees (Princeton, Yale) and Stephen Breyer, John Paul Stevens and David Souter have one each (Penn, Princeton, and Harvard respectively). While I am not knowledgeable about all foreign judges, the two I did recognize from the Ivy lists, getting two honorary degrees each, were Albie Sachs of South Africa and Aharon Barak of Israel—two of the most famous left-leaning jurists from abroad. Indeed, some of Barak's opinions make those of William O. Douglas seem modest and lawful.
Against all this celebration of left-liberalism, Brown and Yale did give honorary degrees to Sandra Day O'Connor, the swing justice of her day and a moderate conservative. But no Ivy League University has ever awarded such a degree to anyone sitting now on the right of the Court. What makes this performance even more obviously ideologically driven is that these academic institutions have neglected the one who has had the most academic influence—Antonin Scalia.
A Culture of Authenticity versus a Jurisprudence of Principle
Our literary, journalistic, and thespian culture is, to put it mildly, not hospitable to conservatism in general or the legal formalism with which conservatives have long been associated. The obvious, but shallower reason, for this clash, is that our cultural elites of every kind are overwhelmingly left-liberal. The deeper reason is that much of our culture is so driven by questions of personal identity and authenticity that it has trouble even comprehending the impersonality of the principles that are at the heart of republican constitutionalism.
The Originalist, a play about Antonin Scalia, at the Arena Stage illustrates both of these problems. The conceit of the play is that Scalia has hired a liberal law clerk, Cat, and they argue about different cases. But the author does not spend nearly enough time explicating originalism or for that matter any other jurisprudence to make the play a battle of ideals. As I say in my review for City Journal, the playwright John Strand is no Tom Stoppard and "has written an intellectual ghost story, in which shadows of ideas fret their minutes on the stage."
It almost goes without saying that play trots out the usual stereotypes of conservatives.
Originalists Need a Distinctive Theory of Precedent
In Comptroller v. Wynne, the Supreme Court this week invalidated a Maryland tax on the basis of the dormant commerce clause, despite claims by Justice Antonin Scalia and Justice Clarence Thomas in dissent that the dormant commerce clause is not grounded in the original meaning of the Constitution. Michael Greve celebrated the majority's choice to follow long established dormant commerce clause precedent and implicitly suggested that Wynne provides evidence that originalism is an implausible and even futile interpretive theory.
Michael is half-right. Originalism is certainly an inadequate theory if it cannot find a principled approach to precedent, like that on which the Wynn majority relied. Certainly, it is not politically possible for the Court to discard settled precedent when to do so would have enormous costs for society or when the precedents have become as accepted as constitutional provisions themselves. But, as Mike Rappaport and I have argued, the Constitution contemplates that justices will follow precedent. Moreover, sensible precedent rules are available that preserve the bite of originalism and still permit the Court to affirm a substantial number of well-established precedents.
Thus, my criticism of the opinions in Wynne is quite different from Michael's.
Creating a Unitary Supreme Court
I am grateful for Michael Greve's post on my analysis of Our Two Supreme Courts. I wholly agree with his positive point. The political or aristocratic Court comes to the fore not only in constitutional cases, but in statutory interpretation cases that implicate constitutional values or important political issues. Preemption is a fine example because the broader is the scope of preemption, the more limited is the authority of the states.
I am in less agreement with his normative point. I had argued that the way to dissolve the difference between the legal and the political court was for the Court always to take the same formalist approach that it does in ordinary statutory cases, like interpreting the bankruptcy code. Michael doubts that such formalism is regularly possible in constitutional law because of the open ended nature of constitutional provisions. But Mike Rappaport and I have argued previously that the common claims that constitutional provisions are abstract and need to be filled in by judges may well be false. Once we know more about their history, we can often determine a clearer meaning of the constitutional provision at issue.
Chevron Deference About to Hit a Snag
A recent Supreme Court order portends interesting limits on the Securities Exchange Commission and on Chevron deference. Earlier this fall, I observed how the SEC evades jury rights and other rights of criminal defendants by proceeding against them in SEC hearings. Now, as noted by Ed Mannino, the Supreme Court is beginning to focus on a related danger.
One Cheer for Scalia on Legal Education
In a speech at William and Mary Law School last weekend Justice Antonin Scalia rejected the idea of a two-year course of legal education and assailed at least some law professors as overpaid teachers of irrelevant material. He is wrong about the two-year path, but half right about some professors.
Scalia's rejection of the two-year proposal is rooted in his view that three years are necessary to create "a legal professional," but he provides no evidence for this claim. He does not consider the history of the requirement, which suggests that a three-year law course arose as a method of shielding incumbents from competition, particularly from immigrant families who would have difficulty affording lengthy legal education. Economists are generally wary of process requirements—like a three-year requirement for a law degree—as opposed to a performance requirement—passing the bar exam. The former tends to create a barrier to entry with no clear relation to improved output.
Scalia also does not take into account that law is a very variegated profession and that legal education should reflect this variety.


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The world is swimming in a sea of information, due to modern technology. Many people rely on their mobile phones, or else they risk appearing less competitive to their peers and superiors.
The Mobile Device: Everybody's Best Friend
Anyone who has a smartphone can browse the web and update their social media accounts. This is great for web users who want to always be online and businesses trying to establish their brands on the cyberspace. The convenience and accessibility of mobile sites increase sales, generate traffic and boost engagement, as mobile users outnumber PC users. Many people, especially those considering their choices on the road, usually use their mobile phone to search for the information they need.
Share Before Expecting Anyone to Care
Create and design websites that are compatible with mobile phone configurations. These often include "share" buttons for easy sharing of content through social media. You can show your location with one-click Google Maps and directions. You can also connect to FourSquare, Facebook Places, Yelp, and Google Places from your mobile website. The result is a website that will provide your visitors a great browsing experience anywhere they go. This way, your mobile website can generate traffic, boost customer engagement, and eventually increase sales.
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There are mobile website builders that are willing to do the job for you, along with doing analytics to know where your traffic is coming from and where they're going to. They will tell you that all people are attracted to freebies, so create special offers, along with multiple and redeemable coupons. Research can be quite boring for most people, so cute, interactive graphics can make it work for you. Finally, allow your mobile website visitors to translate your mobile website content into over thirty languages with one click.
Go mobile or risk obscurity in cyberspace. Look around for inspiration, ask for professional advice, and never be afraid of asking for criticism from the experts in your field.


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My wife and I have lived in Germany for two years and have a flight to Idaho on Friday. She has fluid in her kidney and an overractive thyroid.
If approved by the doctor here in Germany, we could postpone treatment until we secure insurance in the states. Of course, without inurance this ordeal could bankrupt us pretty quickly. We are "low-income" and probably eligible for Obamacare. I need to know how quickly we can get insurance if we moved to the US. Does anyone have an idea?
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Ksenych explains that their customers come from several contact channels: "Our contact information is displayed at the very top of every page on our website. A potential customer can contact us by phone, email us directly or submit a detailed moving quote request. These options accommodate all needs, from those that want to speak to someone right away as well as those that might be multi-tasking and prefer to send a detailed email."
If those three things describe you, then think about becoming a virtual assistant. What exactly you'll do depends on what your skills, experience, and network of contacts are, but you can expect tasks from data entry to customer management, research, scheduling, and more. And of course, like all online business ideas, you can do this one from anywhere.
4. Good Sync is another syncing service that does a ton of stuff and has a lot of customization options. I use it to sync all my files locally to a memory card that I can just pop into a new computer whenever I want. This is a good option because it's so fast, but it isn't as convenient as Sugar Sync if you're wanting to backup to an online server.
Tony Zohari, BSc, MSc Business Administration, in mid 80's Tony worked for TagNama Co. on design and implementation of the CQI system for the construction industry. After his study as System Automotive Technician at Wenstromska Institute in Vestrås/Sweden in early 90's, he moved to Gothenburg, and continued his study at Tröllhattan University in Technical Production and Computerized System. While still at university on a work placement at SAAB he became involved in the development and implementation of JIT production & stock control system for the car manufacturing plants. In mid 90's Tony went to Stockholm and studied at Frans Schartaus business school and graduated in Business Administration and then worked few years as bookkeeper and SME's business consultant before travelling to London in late 90's and specialised himself in marketing and new media. Tony started his career in the new media as early as 1998 when he worked for London International Education Foundation Limited on development of Online Learning System EDUCATOR. During his career he has worked with some of top brands, including MSN, ABB Group, Traffic Interactive, CITB, BBC, Ernst and Young, Toyota, Presentation Graphic and Presentation Services Group… Tony has many years marketing and production experience from various service industries and graduated form Stockholm University School of Business with an MSc in Business Administration. He has also received London Chamber of Commerce & Industry Diploma, and studied CIM.
Stay Constant — Everything takes time, if you stop posting on Social Media you will not get results. Notice how Gary Vaynerchuk suggest for you to focus on your organic reach for an entire year… He doesn't suggest 2 months, or a week, but a year. It's very important to stick with social media because when you do your results will reflect your efforts.
They don't fit into the corporate environment: Entrepreneurs don't often thrive in corporate environments. It's often very restricting for their growth. They may dislike the lack of control they have in their role or the office politics. In general, you can spot an entrepreneur in a corporate environment as they're usually trying to gain more control in their role and learning their coworkers responsibilities to better understand how everything fits together.
Robo-advisors are diversified investment accounts that are automatically managed by a computer algorithm (as opposed to a human money manager). If you want to invest, but don't have the money, or don't want to invest with a money manager, robo-advisors are for you! Robo-advisors make investing easier—and cheaper—so they're perfect for new investors.
Hootsuite – Listed 4 out of 20 times. Like Buffer, Hootsuite is a very handy tool to help schedule and monitor all of your social media activities. They also have been around for a while so they should know what they are talking about. Their latest trending posts are about: (i) How to Get More Facebook Likes: 10 Tactics That Actually Work, (ii) 40+ Useful PC Keyboard Shortcuts for Social Media Pros, and (iii) How to Advertise on Facebook: The Complete Guide.
As well as giving opinions it's important to guide companies on how to collect them. Research designs are, therefore, a critical component of any research process. It includes the formulation of survey texts and questions (e.g., textual, multiple choice, drop-down, Likert scale, ranking, file/image, questions, etc.). The surveys sometimes also need to be integrated with a website, database or mail marketing service provider (e.g., Mail Chimp).
It's almost always harder and takes longer to raise startup financing than you think. You must ensure you have a cushion for all the product development and marketing expenses you will incur. In an ideal world, you will have sufficient capital for your operations to break even. Don't worry about diluting your percentage ownership in the company. Developing a great product takes time and money.
Don't sacrifice morals for a quick buck — At the outset, you'll want to do all sorts of things to make money online, but don't sacrifice your morals for a quick buck. Not only will you put people off, but you'll lose Google's trust. You also shouldn't concern yourself with things like Adsense or other ads on a blog before you have around 100,000 visitors per day. Yes, per day.
As of October 2018 almost 4.2 billion people were active internet users and 3.4 billion were social media users (Statista). China, India and the United States rank ahead all other countries in terms of internet users. This gives a marketer an unprecedented number of customers to reach with product and service offerings, available 24 hours a day, seven days a week. The interactive nature of the internet facilitates immediate communication between businesses and consumers, allowing businesses to respond quickly to the needs of consumers and changes in the marketplace.
Working hard is important, and you might not have the chance to rest every day when you first start out, but it is important to know when you are overworked. Many people who buy from youth businesses do so because of the youthful component of what they do, a component built on energy and a fascination with everything they are learning. That energy and fascination can burn out very quickly if you are not well rested and ready to go. This is not to say that you should slack off, but that you should know when you are at a limit and celebrate progress when it occurs.
Hi Sean! Your article is terrific! Yes it is really important to look after these points. See, a businessman must know how to roam around the net. People are all over it, visiting every blogsites, giving articles, sharing each other's links, and commenting about each other and these all leads to having a good camaraderie among business owners! Internet indeed gives us lots of opportunities.
"The most painful mistake I see entrepreneurs make is launching before learning. For example, you may decide you want to launch a marketing consulting company, so you hastily make a website, content and reach out to people, but you haven't yet figured out who your target clientele is. What people actually need help with or what you're specifically good at. So no one bites."
Customers who receive a free product are 20% more likely to spread the word about the free product than they are about a product they paid for. By giving away your product for free you're essentially paying for word of mouth advertising.A great example here is Spotify. They offer a free version to customers but also offer a free 30 day trial of premium ad free music. Once their customers are hooked and see they can get more with paid features, it's really a no brainer to upgrade to a premium account especially after the 30 day free trial.
If you possess a great deal of business experience and knowledge, why not create a business that helps aspiring entrepreneurs find success? You can use your skills to help new business owners get off to a good start and help experienced entrepreneurs keep up with demand. To show off your knowledge and skills and bring in clients, you can also write articles about business on platforms like LinkedIn.
Love 'em or hate him, Gary Vaynerchuk (a.k.a. Gary Vee) has been a pioneer in the digital marketing field since the late 90s. He's a self-described serial entrepreneur and the CEO and co-founder of VaynerMedia, a full-service digital agency serving Fortune 500 clients across the company's four locations. Check out the latest videos on his YouTube channel, The #AskGaryVee Show.
Social Triggers can help to bridge the gap between you and your customers. You will get answers to all your queries. It covers different aspects to help the visitors to choose the right strategy. Plenty of its posts cover digital marketing and its latest trends. The primary target of this blog is the audience and online business owners. Therefore, you will get helpful tips to understand your buyers and to impress them.
Just like optimizing your site to rank for keywords, you can use our online marketing tips to pay to run advertisements on Google so that your business is shown on the first page of search results. Ranking this way is instantaneous where as SEO takes some time before you will be able to see your site on the first page of search results. It certainly pays off to be at the top of the page.


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The house bath may reveal nails that have popped out of the siding or rusting nail heads that have left streaks of rust on exterior walls. If so, use sandpaper or steel wool to clean the nail heads. On clapboard siding, use a nail set to recess the nail head about ⅛ inch below the surface of the wood. Dab on a coat of rust-inhibiting primer (unless the nail is aluminum or nonrusting galvanized steel), and let it dry. Then fill the nail hole with spackle or putty. When the filler is dry, give it a coat of primer. For flathead nails, which cannot be recessed, sand the heads until they're shiny, and coat with primer.
One of the most important steps in selecting a painting contractor is reading ratings and reviews. This is the best way to know exactly what to expect from the company, based on what others have posted. From quality of service to timeliness, there's a lot you can learn about a company before working with them, solely from reading online reviews. And since these reviews are organic (not paid for by the company—hopefully), you can trust that they are honest and truly reflective of the painting contractor's work.
I agree with JHs. If there is no new color on it at all, just talk to the painter about it, if it was an honest mistake (which can happen very easily while painting) your painter should have no problem fixing it. However, in my years of experience, it is not unusual for 2 coats of door paint (good quality) not to cover very well at all. I once painted a red door 7 times, plus a tinted prime coat before I found the door to be a solid color.
cost Of House Painting
I was a painting contractor for many years and never asked for a deposit upfront. A good contractor should have great credit with his suppliers and an even better contract if the deal should go south before the job is done. Get to know your customer and explain how each paint covers so they understand fully before you have to apply 3 or 4 coats. If you didn't bid your job right and the client has already signed the contract then that is on you not the client. Yes I haven had to eat the difference but the client was happy and a return customer for years so I made up for it.
When you move from room to room, consider your color story, or how the colors will interact. Using complementary colors - colors that sit opposite one another on the color wheel, will create a very dramatic look in your home. Choosing analogous colors, which sit beside one another on the color wheel, creates a more subtle appearance. Monochromatic looks can also be very effective in small spaces, when you choose varying shades of one color to give variety, but without definition.
Thanks for asking for our input. I have enjoyed the 'Future House' episodes that you folks have created. And, I think that the amount of segments-per-season seems just about right - any more and it might begin to take the shows into an area that moves away from their core meaning (i.e. - home repair/rehab/construction, etc). Though, it's easy to understand how new and upcoming technologies fit well into TOH/ATOH's overall picture. Also, Ross Trethewey is a good sement host - very knoledgable and enthusiastic - and, as well, he gives the TOH/ATOH audience some 'younger blood' to continue forward with the show's traditions. My thoughts are to stick with 'Future House' segments.And, thanks for all of the good work you folks do in continuing to present to us each year such wonderful productions as TOH and ATOH, which we get to enjoy and benefit so greatly from!
What's in a house painting contract is an important question that comes up as you get deeper into your remodeling venture. Between the time you decide your house needs a new coat of paint and the time the job gets done, a lot transpires. After you've decided on an interior painter or exterior painting contractor, you should have them write a formal contract, and this is what it should include:
Interview your contractor.Before you choose a contractor, get three bids for comparison and ask the right questions. Bunting says you need to know the following: Do they have proper licenses, insurance, and bonding? Do they subcontract the work out? Do they offer written guarantees of their work? "Recommendations from friends and family are always a good measure," adds Rance. "And ask for references from previous customers." http://y2u.be/b6_WEt9k_Hw
Dedicated to developing long-lasting relationships with our customers, our skilled commercial painters always strive to give you the quality you expect in a timeline that's unexpected. At Genesis Total Exteriors, our customers never have to worry about poor workmanship or property damage. Our expert commercial painters have a ton of experience in providing interior and exterior painting services to all types of businesses, including:
house Painting Near Me
Believe it or not, there is more that goes into house painting than putting paint on a wall. There is prep work, clean up, priming and other details that must be addressed, which should be included in your initial quote. Before you sign on the dotted line with a painting contractor, you should get a detailed quote that lists all the steps being taken and how much each service will cost, including:
cost To Paint Exterior Of House
Once you have removed all the loose paint, you should apply an appropriate primer to some of the distressed areas, especially if your paint-removal system has exposed raw wood or bare metal. The kind of primer you use depends on the kind of paint you'll be using later. For latex paint, use latex primers; for solvent-thinned paints, use solvent-base primers; and for metals, use metal primers. Not only do these coatings provide extra protection against the elements, they also form a firm foundation for finishing paints. Also, priming is always required when you're working on new wood.
cost Of Interior Painting
Look for signs of a good contractor.Product knowledge and clear communication are the signs of a good contractor. "Look for a pro who recommends high-quality paints," says Rance. "They should prioritize finish and durability over speed of application for a long-lasting paint job." And, notes Bunting, a good contractor will respond to you in a timely manner.
painter Near Me


text: BUSINESS Moby Reportedly Sells Hollywood Hills 'Castle,' Possibly to Banksy, for Big Profit 12/1/2014 by Marc Schneider FACEBOOK TWITTER EMAIL ME Getty Images Musician Moby attends the Art Los Angeles Contemporary 2014 opening night at Barker Hangar on January 30, 2014 in Santa Monica, Calif. Electronic musician, DJ and known vegan Moby has sold off his castle-like compound in the Hollywood Hills for a hefty profit. According to multiple reports, the Play star, whose given name is Richard Melville Hall, purchased the home for $3.9 million in March 2010, and just unloaded it for an impressive $12.4 million.RelatedBeats President Nabs the Most Expensive House in Silver Lake, Warner Music Exec Ditches the Upper E. SidePandora Founder's Vacation Home Riles Neighbors, Tree LoversLocated above Beachwood Canyon with soaring views of downtown L.A. and the Hollywood sign, the compound was built in 1927 for influential developer L. Milton Wolf. The property, known as Wolf's Lair, spans 6,500 square feet of living space with eight bedrooms, 5 bathrooms, a guest house, a pool house, a "secret" tunnel and turrets.If the rumors are to be believed, the buyer this time is graffiti artist Banksy.Moby, 49, purchased the castle from Mammoth Records founder Jay Faires and spent around $2 million on renovations. House guests over the decades have included the Rolling Stones, the Beatles and Marlon Brando. The artist has been rattling his real estate portfolio of late, having sold his penthouse in NYC's Lower East Side for $2 million in May 2014 and another Hollywood Hills home in June 2013 for an undisclosed sum. FACEBOOK TWITTER EMAIL ME


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The OneGauge system is very simple- you install your selected sensors to the factory sensor locations. These sensors each collect information and send this data to the OneGauge Hub, which is the central "brain" of the system.
- Install the Hub under the hood so wiring can be easily routed to it.
- The Hub sends data to selected screens by Bluetooth, OBDII port, or wired connection.
- Sensors are available to measure just about anything you need!
For more information, view the OneGauge Installation Instructions as well as the FAQs page.
Check out example photos and video demos on our Examples page.


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Billy Jennings (Welsh footballer)
William Jennings (25 February 1893 – 1968) was a Welsh football player best known for playing for Bolton Wanderers, for whom he made over 250 appearances in The Football League. He played for the team in the 1923 FA Cup Final.[2] He also played 11 times for the Welsh national team and later spent a two-year spell in charge of Cardiff City.[3][4][5]
|Personal information
|Full name
|William Jennings[1]
|Date of birth
|25 February 1893
|Place of birth
|Barry, Wales
|Date of death
|1968 (aged 74–75)[1]
|Playing position
|Left half, full back
|Senior career*
|Barry Town
|Bethel Baptists
|Barry Town
|Bolton Wanderers
|National team
|Teams managed
|Cardiff City
|* Senior club appearances and goals counted for the domestic league only and correct as of 11:08, 29 October 2008 (UTC)
Personal lifeEdit
Jennings served as a corporal in the Royal Air Force during the First World War.[7]
- General
- Hayes, Dean (2006). The Who's Who of Cardiff City. Breedon Books. ISBN 1-85983-462-0.
- Specific
- ^ a b Joyce, Michael (16 October 2012). Football League Players' Records 1888–1939 (3rd Revised ed.). Tony Brown. p. 153. ISBN 9781905891610.
- ^ Thraves, Andrew (1994). The History of the Wembley FA Cup Final. Weidenfeld and Nicolson. p. 1. ISBN 0-297-83407-X.
- ^ "Welsh International matches". wfda.co.uk. Archived from the original on 8 March 2014. Retrieved 20 July 2009.
- ^ "The Roaring Twenties". cardiffcityfc.co.uk. Retrieved 9 September 2013.
- ^ "Bill Jennings". League Managers Association. Retrieved 20 July 2009.
- ^ "Jennings Billy Image 6 Bolton Wanderers 1927". Vintage Footballers. Retrieved 9 December 2018.
- ^ "William Jennings | Service Record". Football and the First World War. Retrieved 9 December 2018.
|This biographical article related to a Welsh football defender is a stub. You can help Wikipedia by expanding it.


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By at March 04 2019 00:21:35
If you are planning on starting a business, but you have yet to develop yourself a business plan, you may want to think about doing so. As nice as business plans are, they can sometimes be difficult to make and they can even be time consuming. That is why a large number of individuals make the decision to use business plan templates. If you are looking for a relatively easy way to develop your next business plan, you may want to think about using the internet to find templates. Although you can create your own business plan, all on your own, there are a number of benefits to using the business plan templates that you can find online.
An action plan template can be defined as a document that specifies what steps are to be taken for achieving specific goals. The action plans are necessary not just for individuals but for the entire business organization as well. It contains all the essential details regarding the steps to be taken for the attainment of a single goal or many goals. It acts as a tool for effective and efficient planning for growth of the organization and its overall development as well.
Business plan templates assist individuals in comprehending start up costs, cash flow forecasts, and personal budgets too. They also help produce full sets of financial statements including cash flows and ratio analyses even without accountancy expertise. They are actually the backbones of planning. Additionally, they give total direction to the company, inspire intense researches, and establish goals. Nevertheless, it is also imperative to obtain the right business plan template to avoid mistakes. So, when looking for one, an individual should try out samples before making a purchase. He should decide on his preferred color schemes. Then, he has to make sure that his business plan would perfectly fit into his desired template. Next, he should check for available titles designs and fonts. He should measure his diagrams, graphs, and photos to see if they would also fit into the template. Also, he has to determine if the template would fit into his public profile. He should choose the template that lets him map out the pertinent information in just a short time, as well. And finally, he should test the template if it could be adjusted into any formatting such as type and size.
The template usually provides ways to do keyword research, methods to build websites or blogs and strategies for getting your site listed in Google. Improvement to traffic and profits can be seen when you make use of this kind of template. Unfortunately, people who are new to Internet marketing often fail to follow the guidelines provided in a marketing plan template because they are tempted by some other new strategy. They end up mixing up strategies and leaving out key success factors.


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Since opening our doors in 1972, we quickly became Dallas' one stop shop for all hunting and gunsmithing needs. Our gunsmiths specialize in restoration, general repairs, and anything else you throw at them. We're committed to providing customers with personalized service you won't encounter anywhere else. Come see us!
Mfg Item #: 91220
Mesa Tactical 6-Shell Side Saddle, 12 Gauge, Fits Benelli M2, On-gun shotshell carriers, Black Finish 91220


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A Zionville woman has taken the grand prize in the Pillsbury Bake-Off Contest.
Watauga Online reports Amy Nelson, who previously won the Cozy Breakfast Category in January, has now won the grand prize with her Bejeweled Cranberry-Orange Rolls, inspired by her mother's Cranberry Salad recipe.
As the big winner, Nelson will receive $50,000, a kitchen makeover from GE Appliances and will be featured in Food Network Magazine.


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Welcome to Jackson's Lodge & Outpost
Jackson's Lodge & Outposts is a family-operated business that has been providing guests with finest fly-in fishing and hunting trips in Manitoba.
Based in Lac du Bonnet, Jackson's Lodge is easy to get to. Operating our own air service Adventure Air and our own fleet of highly maintained aircraft.
Over the years, it has become a favorite destination for those in search of great fishing, friendly service and five star accommodation in the North.
Toll Free: 1-800-463-4744
Office: 1-204-345-8322
Website: www.jacksonslodge.com
Email: email@example.com
Mailing Address:
Box 670
Lac du Bonnet, Manitoba
Canada R0E 1A0
Saturday, July 27, 2019
This is our remodelled office for Adventure Air and Jackson's Lodge & Outposts
Posted by Adventure Air at 9:13 AM


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Download Meizu 16 Stock Wallpapers – ZIP File Included
Meizu recently launched the Meizu 16, which is the latest high-end device from the company, featuring Snapdragon 845 chipset and an in-screen fingerprint scanner. It is also the cheapest smartphone with an in-screen fingerprint reader (if we convert the price from Yuan to USD). Meizu's smartphones ship with the custom Flyme OS skin and Flyme OS is known for its clean and minimal interface that also includes minimal icons and wallpapers.
With the Meizu 16, we get a set of beautiful and minimal wallpapers, most of which are also included in Flyme OS 7. You can check our article on the Flyme OS 7 Stock Wallpapers. Anyways, in this article, we have shared the Meizu 16 Stock Wallpapers along with the Google Drive link to the ZIP file of all the wallpapers.
And here is the ZIP file –
Don't miss some more wallpapers –
- Download Samsung Galaxy Note 9 stock wallpapers – ZIP file included
- Download Oppo Find X Stock Wallpapers – ZIP File Included
- Download Nokia X6 Stock Wallpapers – ZIP File Included
- Download Official OnePlus 6 Wallpapers by Hampus Olsson
- Download Xiaomi Mi 6X/Mi A2 Stock Wallpapers – ZIP File Included
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US Sweepstakes & Fulfillment Company
in Marketing Strategy Consultants, Digital Marketing Consultants, Loyalty/Incentive Marketing, Consumer Marketing Consultants, Lead Generation, Web Design, Digital Technology, Gamification, Experiential Marketing Consultants
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in Qualitative Research, Quantitative Research, Healthcare/Pharma Research, Ethnographic Research, Consumer Research
Focus Forward Transcription & Coding Offered in over 165 facility locations nationwide, Focus Forward Transcription is the leader in market research verbatim transcription and note taking. Our work is never outsourced; all transcription is completed
950 W. Valley Road
Suite 2700
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Hanover Research
in Market Research Consultants, Qualitative Research, Quantitative Research, B2B Market Research, Online Surveys/Software, Focus Group Moderators, Consumer Research, Brand/Image Research, Full Service Research, Research Design/Methodology
Hanover Research is a global research and analytics firm that delivers market intelligence and insights to more than 1,000 clients.
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Arlington, Virginia 22203
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CatalystMR is an experienced, high-touch, high quality panel and full service market research service leader providing US & International consumers, b2b, and healthcare panels, full service research solutions and online survey programming & hosting
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Oakland, California 94611
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Isurus Market Research & Consulting
in Advertising Research, New Product Development, Content Marketing, Concept Development, Customer Experience
Isurus is a boutique B2B research firm that delivers insights and intelligence to clients in technology, commercial and industrial sectors.
1500 District Ave.
Burlington, Massachusetts 1803
United States of America


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Get Electricians in Koramangala, Bangalore
- Doorstep repair within 90 mins
- Protection Against Damage Upto INR 10,000
- 30 day post-service guarantee
- Home /
- Bangalore /
- Electricians /
- Koramangala
Need an Electrician for:
based on 3,850 reviews
Bookings done in last 1 year
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Repair & Service at Home
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Our professional will get in touch with you one hour before the service
16 Electricians near Koramangala
- Rabboni VictorHSR Layout, Bangalore, Karnataka, India4.0(17 reviews)
- sshilpa3.5
I asked to bring drilling machine but he did not had appropriate size for which drilling work was incomplete
- mmadhu5.0
Very professional and perfect technician. Very good service
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1Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
2Cameco MS Neuroscience Research Center, University of Saskatchewan, Saskatoon, SK, Canada
3Department of Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada
4Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria
Received date: August 06, 2014; Accepted date: September 23, 2014; Published date: September 26, 2014
Citation: Adiele RC, Adiele CA (2014) Progressive Multifocal Leukoencephalopathy. J Mult Scler 1:118. doi:10.4172/2376-0389.1000118
Copyright: © 2014 Adiele RC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Visit for more related articles at Journal of Multiple Sclerosis
Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-damaging disease of the central nervous system (CNS) in a setting of immunosuppression that is superimposed by concurrent autoimmune diseases such as multiple sclerosis and AIDS or simultaneous administration of immune modulatory monoclonal antibody drugs such as natalizumab. The causative agent is a Polyomavirus known as John Cunningham (JC) virus (JCV) that affects oligodendrocytes and astrocytes resulting in focal, extensive and progressive demyelination across the brain. The pathogenesis of JCV latent and active infection is yet to be fully understood despite significant medical research. To date, no therapeutic intervention has been very effective in addressing the health implications of PML. In this article, we review the current knowledge on the life cycle of JCV, pathogenesis of PML, highlight important tools in the diagnosis, potential targets for management and therapeutic intervention of PML.
Progressive multifocal leukoencephalopathy; JC virus; Oligodendrocyte; Astrocyte; Pathogenesis; Latency; Natalizumab
Progressive multifocal leukoencephalopathy (PML) is a rare, myelin-degrading disease of the central nervous system (CNS) caused by infection of oligodendrocytes and astrocytes by a Polyomavirus known as John Cunningham (JC) virus (JCV), whose name was taken after the first patient in which the virus was first isolated [1]. The virus belongs to the family of polyomaviridae [1-4]. Its genomic constituent is small, circular, and double-stranded DNA molecule of approximately 5100 base pairs that is divided into two protein coding regions (early and late) on opposite side of the non-coding control region (NCCR). The NCCR controls the enhancer and promoter regions of the coding element as well as the center of viral replication [5-7].
This opportunistic pathogen is wide-spread among human population and may or may not be accompanied with inflammatory changes. The primary target of PML is an immunosuppressed individual, inherently in association with autoimmune diseases such as multiple sclerosis and AIDS, inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus and sarcoidosis and or as a side effect of a disease modifying treatment such as monoclonal antibody therapy or cytotoxic drugs [8-11]. A common denominator in all the cases of PML is that the patient's immune system is compromised indicating lack of immunosurveillance.
Pathophysiology of progressive multifocal leukoencephalopathy
The viral agent implicated in this autoimmune disorder has been described over eight decades ago with subsequent identification of the viral particle in intranuclear inclusion bodies of myelin forming oligodendrocytes [12,13] and its isolation from human brain suffering from PML [1]. The disease is associated with a long standing asymptomatic state of latency [1]. It affects many organ systems in the body including the tonsil, kidneys and CNS with a long period of latent inactive infection despite significant antibody seropositivity in the target population. Despite a high prevalence of up to 90% seropositivity, fulminant active infection is considerably very low [14,15]. This suggests that seropositivity does not portend active infection however, an immune compromised individual is at a very high risk of coming down with the infection. PML is been associated with numerous autoimmune and inflammatory diseases such as multiple sclerosis (MS) [9], acquired immune deficiency syndrome (AIDS) [16-21], lymphocytic leukemia [22], or during organ transplant co-administration of immunosuppressant drugs. Recent reports suggesting that immune modulation played critical role in the activation of JCV have attracted a lot of attention [3,9,11,23]. The hypothesis is reinforced by the resurgence of active PML in patients that are undergoing immunomodulatory therapeutic intervention [23,24]. Many of these reports of active PML have been linked to a reactivation of a supposedly "quiescent" JC virus by monotherapeutic or combination immunoregulatory therapy using monoclonal antibodies such as natalizumab, efalizumab, and rituximab [3].
Pathogenesis of progressive multifocal leukoencephalopathy
The life cycle of JCV is illustrated in Figure 1. The first step in tackling the scourge of PML is to have an indebt understanding of the mechanism of disease pathogenesis. PML infection is thought to occur early in the life of an individual and it is most likely transmitted through the natural external orifices of the gastrointestinal and respiratory tracts [25-27]. Subsequently, the virus invades local lymphoid tissue and infect the lymphocytes through which other parts of the body such as bone marrow and kidneys become infected and remain is these sites for a period of latency prior to setting up an active infection in an immune deficient subject [28,29]. It is highly possible that JC virus may have been carried to the brain by B lymphocytes carrier where they remain in a period of latency pending reactivation of the virus due to immunosuppression and lack of immune control. A period of latent infection occurs which is followed by active viremia and lodgement of the virus in various tissues of the body including the kidneys [30], tonsils, [28,31] and brain [32-34] as well as in white blood cells [35,36].
Figure 1: Life cycle and cellular events in JCV infection indicated by numbers accordingly. 1: free JCV binding to carbohydrate [Cm(H2O)n] receptor coupled serotonin (5HT2A) receptors on cell surface, 2: phagocytosis of viral particle, 3: transcytosis and formation of endosome, 4: internalization into endoplasmic reticulum (ER), 5: cytoplasmic translocation from ER, 6: nuclear internalization via nuclear pores for exsheathment and nuclear processing, 7: transcription of early viral coding region, 8: translation of early mRNAs, 9: nuclear relocalization, 10: replication of viral particle, 11: transcription late viral coding region, 12: translation of late viral transcript, 13: nuclear localization of capsids, 14: final nuclear packaging, 15: intracellular release of viral particles, 16: extracellular release of free JC viral progeny ready to infect other cells.
Among the neuroglia, oligodendrocytes and astrocytes are the main targets of JC virus whose infection results in severe demyelination and inflammation marked by infiltration with macrophages [32,37-40]. Following JCV binding to cellular surface sialic acid-linked carbohydrate receptor [41,42] coupled to serotonin receptor, 5HT2AR [43,44], the viral particles become internalized by endocytosis (Figure 1). Endosome is formed, mediate by a vesicular capsid protein, clathrin, for onward translocation into the nucleus [45,46] via the endoplasmic reticulum (ER) [47]. In the nucleus, the viral particle undergoes DNA replication, transcription and encapsulation [38,39] and subsequently released as free active progeny virions with the potential to infect many more cells. Sequel to the release of the viral particle, the infected neuroglia undergoes necroses that is accompanied by the infection of adjacent glial cells in progression and terminally result in precipitation of PML.
Active progressive multifocal leukoencaphalopathy
The mechanism of activation of latent PML infection is unclear and requires more investigation to unravel the order of events that leads to activation of latent infection. It has been observed that HIV-1 transactivator protein Tat is a positive effector of transcription and replication process of PML. This observation offers some explanation on the concomitant increase in active PML infection in AIDS patients [48,49]. In a setting of immune deficiency and lack on immune surveillance, increased viral multiplication that subsequently results into increased viral load will promote dissemination of the viral particle and formation of lesions associated with PML. Further, depressed immune system is incapable of fighting infection and clearance of the viral particle because of lack of cells that are involved in immunosurveillance such the cytotoxic CD8 T cells whose role of fighting and eradicating infection is impaired [50]. Immune modulation by monoclonal antibody therapeutic agents prevents translocation of T lymphocyte through the BBB. This eventually reduces T cell-linked immunosurveillance in the brain that result in the promotion of downstream activation of latent PML infection in the brain [51].
Lesion location and clinical characteristics of progressive multifocal leukoencephalopathy
Like most demyelinating diseases of the CNS that affect oligodendrocytes and to some extent astrocytes such as multiple sclerosis, PML exhibit multiple symptoms, affecting several organs and systems of the body that receive neural input from the brain and therefore the clinical picture is non-specific. The clinical manifestation and neurological impairment in PML are dependent on demyelination, location, size and distribution of PML plaques in the brain. Lesions could be focal, more generalized and observed throughout the brain including the cerebral and cerebellar hemispheres as well as the brain stem [52]. Demyelinated plaques are sometimes confluent, bilateral, and asymmetrical and may be localized in both the gray and subcortical white matter as seen in MRI [53]. Involvement of the cerebral subcortical and periventricular white matter may interfere with motor function implicating pyramidal and or extrapyramidal motor control centers, gait ataxia, altered mental status, speech disorders, sensory and visual impairment [54-56]. All regions of the cerebral hemisphere are potential targets of attack by this virus; however the frontal, parietal and occipital lobes are most frequently affected [57]. Accompanying seizure is suggestive of gray matter involvement [56,58]. The deep gray matter of the cerebrum and the brainstem are not spared by JC virus. Lesions are distributed in the basal nuclei, thalamus and pontine gray and white matter [59,60]. PML lesion localization in the cerebellum is inevitably expressed as cerebellar syndrome [61-63]. Sometimes, meningitis and meningoencephalitis have been associated with JCV infection suggesting that this viral particle play some role in promoting inflammatory changes in the brain [64,65]. When inflammation is involved especially during the degradation of myelin sheaths, inflammatory cells such as macrophages are recruited to clean-up by-products of myelin breakdown [66].
Diagnosis of progressive multifocal leukoencephalopathy
A combination of clinical signs, laboratory tests, histopathological findings and diagnostic imaging techniques are employed to arrive at a definitive diagnosis of PML. Detection and identification of JC viral particle, protein and or DNA fragments in brain tissue samples and or cerebrospinal fluid polymerase chain reaction (CSF-PCR) for JC virus DNA could serve as a definitive diagnosis of active JCV infection [1,66]. Histopathologically, PML presents as focal or extensive and progressive demyelination and rarely accompanied by inflammation [67]. Histopathology is still the gold standard diagnostic technique to identify PML but it is flawed by its invasiveness and can only be carried out on biopsy or autopsy samples. Further, histological investigation only gives a snap shot in time event, which makes it difficult to provide crucial information on the onset, progression and evolution of disease pathogenesis over time. However, clinical and biomedical imaging techniques such as MRI are essential and supportive howevere findings have to be correlated with histopathological observations [59,60].
Therapeutic intervention in progressive multifocal leukoencephalopathy
To date, there is relatively no effective treatment for PML. Many therapeutic agents have been used to mitigate the health effects of PML with variable or no significant beneficial effects and sometimes the adverse effects of the drug dominate [68]. Several therapeutic targets have been suggested taking into account the life cycle of JCV and the pathogenesis of PML (Figure 1) [53], but attempts to harness the high points of these targets for treatment intervention have not been clinically very successful in vivo [68,69]. The objective of any therapeutic intervention is to disrupt the life cycle of JC virus from the time of infection of the cell through intracellular transformation to the release of newly formed active viral progeny (Figure 1) [53]. These may include inhibition of viral-surface receptor interaction and internalization, DNA replication, transcriptional, and translational processes [53].
Serotonin (5HT2A) receptor antagonist, Mefloquine, a substrate of the P-glycoprotein transporter and antimalarial medication inhibits JC viral adsorption, phagocytosis into the cell, and viral DNA replication. It showed some promise against JCV in vitro [70], but the in vivo result was variable [71]. The same is true of Mefloquine analogue and a serotonin receptor blocker, mirtazapine [72]. The clinical trial with cytarabine (cytosine arabinoside), a Viral DNA synthesis inhibitor, failed to show any clinical benefit in PML patients [73-75] however some studies showed positive results [76-78]. The result of interluekin-2 clinical trial was quite variable and unconvincing [79,80]. Similarly, treatment with beta-interferon, an inhibitor of viral replication, yielded variable results [81,82]. The effect of cidofovir, an antiviral drug and inhibitor of viral replication on PML was variable [83,84]. Further, clathrin-mediated endocytosis [38] inhibitor, chlorpromazine, acting singly or in combination with clozapine showed some prospect on glial cell culture in vitro [85] but it was of little or no benefit in clinical trial in vivo [69]. So far, there is no treatment intervention that is effective in addressing the health effects of PML. The objective of any therapeutic intervention in PML is to improve and maintain a very healthy immune system that will promote immune surveillance and prevent immunosuppression. The hypothesis is reinforced by the beneficial effect of IL-2 administration that restored the immune status and improves the level of CD4+ count [79].
Several predictions and unanswered questions abound in the pathogenesis of PML with respect to mode of transmission, internal localization of the latent infection, mechanism of reactivation of the rather "quiescent" viral particles, dissemination and establishment of lesions pathognomonic to PML as well as available treatment options that will be beneficial for PML patients. Clearly, any attempts to address these questions would require more research.
DR. R. C. Adiele is a Fellow in the Canadian Institutes of Health Research Training grant in Health Research Using Synchrotron Techniques (CIHR-THRUST). Pharm. C. A. Adiele is a medical writer and we are grateful for her rigorous and insightful review of earlier versions of this article.
The authors declare that they have no financial or other conflicts of interest in relation to this review article and its publication.
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