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In clinical studies in adult patients with testosterone propionate side effects taking atomoxetine, the incidence of urinary retention was higher in comparison with the placebo group. Complaints potentially urinary retention may be regarded as the result of the use of atomoxetine. Use with caution in patients with a history of seizures. You must stop taking atomoxetine in the case of seizures, which can not be explained by other reasons. Use in children. There are not enough data on the safety and efficacy of atomoxetine in children under 6 years. The effectiveness of atomoxetine treatment for more than 18 months of treatment and safety of their more than 2 years have not been evaluated systematically. The use in the elderly. Atomoxetine safety and efficacy in elderly patients has not been established. Aggressive behavior or hostility. Aggressive behavior or hostility is often observed in children and adolescents with ADHD. Irrefutable evidence that atomoxetine may cause aggressive behavior or hostility does not exist. However, in clinical studies of aggressive behavior or hostility were more frequent in children and adolescents taking atomoxetine (no statistically significant differences when compared with the placebo group). Patients receiving treatment for ADHD should be monitored for the emergence of their aggressive behavior or hostility. Psychotic and manic symptoms. We know about the cases of psychotic and manic symptoms, including hallucinations, delirium, and abnormal rise of mood during treatment with atomoxetine at therapeutic doses in children and adolescents.If you have any of these symptoms, it is recommended to evaluate the extent of their connection with taking atomoxetine and, if necessary, to consider the abolition of the drug. The following symptoms have been observed in testosterone propionate side effects patients receiving atomoxetine: anxiety, agitation, panic attacks, insomnia, irritability, impulsivity, akathisia. Patients taking atomoxetine should be seen by a doctor in relation to the development of these symptoms. Parents and relatives should carefully monitor the appearance of all of the above symptoms and suicidal thoughts in children and adolescents taking atomoxetine and immediately report it to your doctor. Driving and perform activities that require attention The drug may be accompanied by sleepiness. In this regard, patients taking atomoxetine, caution should be exercised in the management of dangerous mechanical means, testosterone propionate side effects including the car, as long as they are not sure that atomoxetine does not cause any disturbances. comprar ciclos de esteroides comprar esteroides comprar esteroides anabolicos 7 keto dhea bodybuilding steroids uk bodybuilding games Related Posts testosterone propionate testosterone propionate dosage testosterone propionate 100mg testosterone enanthate vs propionate propionate testosterone what is testosterone...Read More
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Agents affecting gastric acidity. Drugs that increase the testosterone propionate dosage of gastric juice (hydrochloride magnesium / aluminum hydroxide, omeprazole) do not affect the biological digestibility of Atomoxetine. Agents acting on the secretion of norepinephrine. Agents acting on the secretion of norepinephrine should be administered with caution with atomoxetine because of the potential gain or synergistic pharmacological effects. Drugs with high affinity to plasma proteins. Atomoxetine has no effect on the binding of warfarin, acetylsalicylic acid, phenytoin and the diazepam to human albumin. Drugs with a known effect of lowering the threshold for seizure activity (Antidepressants, neuroleptics, mefloquine, tramadol). Caution must be exercised with concomitant administration. Cautions Symptoms as impaired attention and hyperactivity (identified in more than one social environment, such as at home and at school) can manifest as a concentration deficiency, distractibility, excessive restlessness, impulsiveness, disorganization, restlessness, and other similar conduct disorders diagnosis should meet the criteria . Suicidal ideation and behavior. On the background of the drug testosterone propionate dosage in clinical trials in children and adolescents increases the risk of suicidal thoughts. In the course of 12 clinical studies in 2200 patients (including 1357 patients treated with atomoxetine and 851 patients receiving placebo), one group Atomoxetine in 0.37% of cases were identified the development of suicidal thoughts (5 out of 1357 patients) in the placebo group, suicidal thoughts were not identified. During these clinical studies reported a suicide attempt, suicide was not completed. Allergic reactions. In rare cases, patients taking atomoxetine, marked allergic reactions such as rash, angioedema, urticaria. .Atomoxetine should not be used for at least 2 weeks after discontinuation of treatment should not begin within 2 weeks after discontinuation of atomoxetine. The cardiovascular system. Many patients taking atomoxetine, there was a slight increase in pulse . In most cases, these changes testosterone propionate dosage were not clinically significant effect. Atomoxetine should be used with caution in patients with hypertension, tachycardia, with cardiovascular disease or cerebrovascular. Cases of orthostatic hypotension are also marked. Used with caution in conditions that may lead to hypotension. Use with caution in patients with hereditary or congenital acquired prolongation. Against the background of the use of stimulants, registered for the treatment of children with rough heart disease, in violation of its structure was identified an increased risk of sudden cardiac death. Atomoxetine does not belong to the class of stimulants, because it has an alternative mechanism of therapeutic action in the treatment of testosterone propionate dosage. However, given the total registered indications for use , caution should be exercised when using atomoxetine in patients with: severe physical congestion, while taking psychostimulants, family history of sudden cardiac death. Atomoxetine should not be used in patients with heart disease rough. Violation of the liver or kidney. It was reported about rare cases of serious liver injury in patients receiving atomoxetine (described two cases of pronounced increase in liver enzymes and bilirubin...Read More
testosterone propionate
Nausea and vomiting may occur in about 9% and 11%, respectively, especially for the first month of testosterone propionate treatment. However, these episodes were usually mild to moderate severity, were temporary and would not cause discontinuation of treatment in a significant number of cases. In placebo-controlled trials in children treated with atomoxetine, noted an average increase in heart rate of 6 average increase in systolic and diastolic blood pressure by testosterone propionate. Art. compared to placebo.In a placebo-controlled studies in adults treated with atomoxetine, mentioned average increase in heart rate is 6 beats / min and the mean systolic. The most common symptoms in acute or chronic overdose of atomoxetine monotherapy, were somnolence, agitation, hyperactivity, behavioral disorders, and symptoms from the gastrointestinal tract. Most events were mild to moderate in severity. Also showed signs and symptoms of the activation of the sympathetic nervous system of mild to moderate (eg, mydriasis, tachycardia, dry mouth). All patients had regression of such symptoms. In some cases, seizures were observed with an overdose of atomoxetine. Also reported cases of acute fatal overdose when receiving atomoxetine in combination with at least one other drug. Treatment of overdose It is recommended to provide ventilation, to monitor cardiac function and vital signs, and symptomatic and supportive treatment. It can be shown gastric lavage, if passed not long after taking the drug. It may be useful for the activated carbon absorption limit. Since atomoxetine has a high affinity to plasma proteins, overdose treatment by dialysis rather be impractical. The interaction with other drugs Agonists beta-adrenergic receptors. Atomoxetine should be used with testosterone propionate caution in patients taking beta 2 agonists, as it may intensify their effects on the cardiovascular system. In adult healthy volunteers, the effect of the drug salbutamol in a standard inhaled dose of 200 mg on hemodynamics was insignificant compared to the effect of the indicated dose of the drug when administered intravenously. The simultaneous use of atomoxetine in the dose of 80 mg / day for 5 days have not resulted in an increase of these effects of albuterol. Heart rate after multiple inhalations of albuterol at a dose of 800 micrograms was characterized in a similar values as monotherapy, or in combination with the use of atomoxetine. Co-administration of atomoxetine with drugs causing prolongation of the interval (neuroleptics, antiarrhythmics, moxifloxacin, erythromycin, tricyclic antidepressants, lithium carbonate), as well as drugs that cause electrolyte imbalance inhibitors increase the risk interval prolongation. in vitro studies suggest that administration of inhibitors of cytochrome P450 metabolism in patients with low testosterone propionate does not increase in plasma concentration of atomoxetine. Patients applying inhibitor drugs, recommended a gradual titration of atomoxetine. Drugs affecting blood pressure. Because of the possible effects on blood pressure atomoxetine must be used with caution in combination with drugs affecting blood pressure. Related Posts testosterone propionate side effects testosterone propionate dosage testosterone propionate...Read More
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Conditional beta-blocker (atenolol), which is part of primobolan depot bayer: – contraindicated in heart failure decompensation (see section "Contraindications".), But can be used for those patients whose signs of heart failure under control. Caution should be exercised in relation to patients with reduced cardiac reserve; – used with caution in patients with atrioventricular block of I degree – used with caution in patients with angina l, – although contraindicated in expressed violations of the peripheral circulation (. See section "Contraindications"), may also aggravate less severe peripheral circulatory disorders; – may modify the tachycardia in hypoglycemia; – may mask thyrotoxicosis phenomena; – in the development against the backdrop of bradycardia therapy (slowing of the heart rate up to 50 cuts per minute) with a clinical simtomatiku should reduce the drug dose (the dose is determined by the attending physician) ; – should not be abruptly cancel in patients suffering from ischemic heart disease; – may increase primobolan depot bayer the sensitivity to allergens and cause severe anaphylactic reactions muscle depot reviews, and therefore patients on therapy desensitized should take the drug with caution. These patients may not respond to the usual doses of epinephrine used to treat allergic reactions; – used with caution in patients with broncho-obstructive syndrome, in case of worsening of bronchial conductivity should be abolished Tenoretik and assign treatment of beta-agonists (eg, salbutamol). Caused by the action of chlorthalidone included in the Tenoretika: – hypokalaemia may occur. You should regularly monitor the level of potassium, particularly primobolan in elderly patients, patients receiving cardiac glycosides for the treatment of heart failure, in patients with an unbalanced diet (foods low in potassium), or in patients with complaints of disorders of the gastrointestinal tract. Patients receiving cardiac glycosides, hypokalemia may predispose to cardiac arrhythmias; – caution should be exercised in relation to patients with severe renal insufficiency primobolan depot bayer . May occur impaired glucose tolerance. Care should be taken in when applied chlorthalidone in patients with known predisposition to diabetes; – hyperuricemia may occur. Usually there primobolan depot is only a slight increase of uric acid in blood serum, but in some cases may require the use of agents which promote excretion of uric acid. Related Posts bayer primobolan depot methenolone enanthate primobolan depot side effects primobolan depot primobolan depot cycle primobolan depot for...Read More
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In applying methenolone enanthate or any of its components, the following side effects have been reported: Laboratory parameters: hyperuricemia; hyponatremia (related to chlorthalidone); Hypokalemia: impaired glucose tolerance (see the section "Special instructions".). Since the cardiovascular system: bradycardia; increased symptoms of heart failure; orthostatic hypotension, which may be accompanied by syncope;extremities cold snap. In susceptible patients may cause arrhythmias, symptoms of intermittent claudication, Raynaud's syndrome. On the part of the central nervous system: confusion; dizziness;headache; paresthesia; change of mood; nightmares; psychosis and hallucinations; sleep disturbance; . fatigue of the digestive tract: dry mouth; gastrointestinal disorders (diarrhea); Rare cases of increase in the level of "hepatic" transaminases; rare cases of liver toxicity with symptoms of intrahepatic cholestasis; . nausea (related to chlorthalidone) Hematologic: leukopenia; purpura; . thrombocytopenia With the Skin: alopecia; dry eyes; psoriasiform skin reactions; exacerbation of psoriasis; skin rash. The respiratory system: bronchospasm may occur in patients suffering from bronchial asthma or having in the anamnesis on bronchospasm. On the part of the senses: blurred vision. Other: increase in the number of anti-nuclear antibodies primobolan side effects, although the clinical significance of this fact is not clear. In the case of if any of the above reactions may adversely affect the health of the patient should consider the abolition of the drug. Overdose Symptoms of bradycardia include The symptoms of an overdose, a decrease in blood pressure, congestive heart failure and bronchospasm. Treatment Careful observation; treatment in the intensive care unit; gastric lavage, administration of activated charcoal and laxatives to prevent absorption of the drug still present in the gastro-intestinal tract; the use of plasma or plasma substitutes to treat hypotension and shock. Perhaps the use methenolone enanthate of hemodialysis or hemoperfusion. In severe bradycardia – intravenous infusion of 1-2 mg of atropine and / or the installation of a pacemaker. If necessary, you methenolone enanthate can enter further intravenous bolus of 10 mg of glucagon. If necessary, this procedure may be repeated, or followed by the intravenous administration of glucagon hold at a rate of 1-10 mg / hour depending on the response. If no response to glucagon or absence of intravenous glucagon can enter beta-1- adrenoagonists – dobutamine in a dose of 5.10 ug / kg / min. Dobutamine, due to the positive inotropic action can also be used for the treatment of hypotension and congestive heart failure. Possibly, the dose will be insufficient data to cardiac arrest symptoms associated with beta-adrenoblockade, a large overdose cases. Therefore, if necessary dobutamine dose should be increased to achieve the desired response in accordance with the clinical condition of the patient. Bronchospasm typically docked via bronchodilators. When significant diuresis – introduction of fluid and electrolytes. INTERACTIONS WITH OTHER MEDICINES AND OTHER FORMS OF INTERACTION Use of beta-blockers in combination with blockers "slow" calcium channels, has a negative inotropic effect, such as verapamil, diltiazem, can lead to the strengthening of this...Read More
primobolan depot
Following oral atenolol absorbed from the gastrointestinal tract by 40-50%. After ingestion of the primobolan depot the maximum plasma concentration is reached 2-4 hours. Atenolol primobolan depot undergoes no significant hepatic metabolism, and over 90% of absorbed drug enters the systemic circulation intact. The half-life – about 6 hours, but can be increased in cases of severe renal insufficiency, because the selection of the drug occurs primarily through the kidneys. Atenolol poorly penetrates the tissue because of its low solubility primobolan side effects in lipids, and its concentration in the brain tissue is low. Communication with a minor plasma protein (about – 3%). After ingestion chlorthalidone absorbed from the gastrointestinal tract by 60%, the maximum plasma concentration is observed after about 12 hours after ingestion of the drug. The half – about 50 hours, and excretion occurs mainly kidneys turn. Chlorthalidone binds to plasma protein by about 75%. The simultaneous use of atenolol and chlorthalidone has little effect on the pharmacokinetics of each. Tenoretik effective for at least 24 hours after oral administration of single daily doses. INDICATIONS Hypertension. CONTRAINDICATIONS hypersensitivity to any component of the drug bradycardia; cardiogenic shock; severe hypotension; metabolic acidosis; The expressed disturbances of peripheral circulation; atrioventricular block II and III degree; sick sinus syndrome; untreated pheochromocytoma; Chronic heart failure primobolan in a decompensation stage age of 18 years (effectiveness and safety have been established)Precautions: atrioventricular block I degree, Prinzmetal angina, severe bradycardia (.. Heart rate less than 60 beats / min), disorders of water and electrolyte balance of blood, advanced age, impaired renal function, bronchial asthma (a history), chronic obstructive pulmonary disease primobolan depot, hyperthyroidism, diabetes mellitus.Pregnancy and lactation Tenoretik should not be given to pregnant or lactating.DOSAGE AND ADMINISTRATION Adults 1 tablet per day. Most hypertensive patients use one tablet methenolone enanthate per day Tenoretika gives satisfactory results. Increasing the dose is not effective, if necessary, can be further assigned to other antihypertensive agents, such as a vasodilator. Elderly patients for this age group often require a lower dose of the drug (atenolol), which is determined by the attending physician.Patients with renal impairment Caution should be exercised in patients with primobolan depot impaired renal function. In patients with creatinine clearance (less than 35 ml / min), the drug can be used only after titration of the individual components of the drug. Related Posts primobolan depot side effects methenolone enanthate side effects methenolone enanthate primobolan depot for sale bayer primobolan depot primobolan depot...Read More
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Primobolan depot cycle influence: On the part of the cardiovascular system: heart rate, shortness of primobolan depot cycle breath, marked reduction in blood pressure, fainting, vasculitis, edema (swelling of the ankles and feet), "tides" of blood to the face, rarely – arrhythmias (bradycardia, ventricular tachycardia, atrial flutter) , chest pain, orthostatic hypotension, very rarely – the development or exacerbation primobolan side effects of congestive heart failure, arrythmia, migraine.On the part of the central nervous system: headache, dizziness, fatigue, drowsiness, mood changes, seizures; rare – loss of consciousness, hypoesthesia, nervousness, paresthesia, tremor, vertigo, fatigue, malaise, insomnia, depression, unusual dreams, very rarely – ataxia, apathy, agitation, amnesia. From the digestive system: nausea, vomiting, epigastric pain, rarely – increased level of "liver" transaminases and jaundice (caused by cholestasis), pancreatitis, dry mouth, flatulence, gingival hyperplasia, constipation or diarrhea, rarely – gastritis ,, increased appetite. From the urogenital system: rare – pollakiuria, painful desires urination, nocturia, sexual dysfunction (including potency decrease), rarely – dysuria, polyuria. For the skin: very rarely – dermatoxerasia, alopecia, dermatitis, purpura, skin discoloration.Allergic reactions: itching, rash (including erythematous, maculopapular rash, urticaria), angioedema. From the musculoskeletal system: rarely – arthralgia, arthritis, myalgia long-term use, very rarely – myasthenia gravis. The other: seldom – gynecomastia, poliurikemiya, increase / reduction in weight body, thrombocytopenia, leukopenia, hyperglycemia, impaired vision, conjunctivitis, diplopia, eye pain, tinnitus, back pain, dyspnoea, epistaxis, increased sweating, thirst; very rarely – a cold clammy sweat, cough, rhinitis, parosmiya, taste disturbance, arushenie accommodation, xerophthalmia. Overdose Symptoms: marked reduction of blood primobolan depot cycle pressure, tachycardia, excessive peripheral vasodilation, tachycardia. Treatment: gastric lavage, the appointment of activated carbon, the maintenance function of the cardiovascular system, the control parameters of the heart and lung function, elevated position limbs, control of blood volume and diuresis primobolan results. To restore vascular tone – use of vasopressors (in the absence of contraindications to their use); to eliminate the effects of calcium channel blockade – intravenous calcium gluconate. Hemodialysis is not effective. Interactions with other drugs inhibitors of microsomal oxidation increase the concentration of amlodipine in plasma, increasing the risk of side effects, and inducers of microsomal liver enzymes – reduce. Antihypertensive effect of weakening non-steroidal anti-inflammatory drugs, especially indomethacin (sodium retention and synthesis of prostaglandins kidney blockade), Alpha adrenostimulyatorov , estrogens (sodium retention), sympathomimetic. Thiazide and "loop" diuretics, alpha, beta-blockers, veropamil, angiotensin-converting enzyme inhibitors and nitrates increase antianginal and antihypertensive effects. Amiodarone, quinidine, alpha 1-blockers, antipsychotic drugs (neuroleptics) and blockers "slow" calcium channels may increase the hypotensive effect. It has no impact on the pharmacokinetic parameters of digoxin and warfarin. Cimetidine did not affect the pharmacokinetics of amlodipine. When used together with lithium preparations primobolan results before and after, may increase manifestations of neurotoxicity (nausea, vomiting, diarrhea, ataxia, tremor, tinnitus). calcium can reduce the effect of blockers "slow" calcium channels. procainamide, quinidine and other drugs causing prolongation of the interval , reinforce the negative inotropic effect and...Read More
primobolan depot side effects
Primobolan Depot (methenolone enanthate) is a steroid that is a derivative of dehydrotestosterone. Has low androgenic activity and moderate anabolic (88% of testosterone). Following oral administration of amlodipine slowly absorbed from the gastrointestinal tract. The mean absolute bioavailability of 64%, the maximum concentration in serum is observed after 6-9 hours. The concentration of stable equilibrium is reached after 7 days of treatment. Food does not affect the absorption of amlodipine. The mean volume of distribution of 21 l / kg body weight, indicating that most of the drug is in the tissues and relatively smaller – in the blood. Most of the drug primobolan present in the blood (95%), bind to plasma proteins. Amlodipine undergoes slow but extensive metabolism (90%) in the liver into inactive metabolites, has the effect of "first pass" through the liver. Metabolites not possess significant pharmacological activity. After a single oral half-life (T 1/2 ) ranges from 31 to 48 hours when re-assigning the T 1/2 of about 45 hours. About 60% of an oral dose is excreted in the urine primarily as metabolites, 10% unchanged, and 20-25% in the feces and in breast milk. Amlodipine Total clearance is primobolan depot side effects In older patients (over 65 years) amlodipine slowed elimination (T 1/2 of 65 hr.) Compared young patients, but the difference has no clinical significance. Elongation T 1/2 in patients primobolan side effects with hepatic failure suggests that long-term administration with drug accumulation in the body is higher than (T 1/2 to 60 hours). Renal failure has no significant effect on the kinetics of amlodipine. The drug crosses the blood-brain barrier. When hemodialysis is not removed. Indications Arterial hypertension (monotherapy or in combination with other antihypertensive agents) Stable and vasospastic angina (Prinzmetal angina) Contraindications Hypersensitivity to amlodipine and other primobolan depot side effects dihydropyridine derivatives; severe hypotension, collapse, cardiogenic shock, pregnancy and lactation age of 18 years (effectiveness and safety have been established). With caution: liver dysfunction, sick sinus syndrome (bradycardia, tachycardia), decompensated chronic heart failure primobolan dosage, mild or moderate hypotension, aortic stenosis, mitral stenosis, hypertrophic obstructive cardiomyopathy, acute myocardial infarction (and for 1 month after) , diabetes, lipid profile, old age. Dosing and Administration Inside, the initial dose for the treatment of arterial giperteizii and angina is 5 mg once daily. The dose may be increased to a maximum of 10 mg once a day. When hypertension maintenance dose can be 2.5-5 mg per day. When angina and vasospastic angina – 5-10 mg per day, once. To prevent strokes -. 10 mg / Thin patients, patients with a short, elderly patients, patients with impaired liver function as a hypotensive agent, administered in an initial dose of 2.5 mg, as a means of antiangialnogo – 5 mg. Not required changing the dose with concomitant administration pronabolin side effects with thiazide diuretics, beta-blockers and angiotensin-converting enzyme primobolan depot side effects. not required dose...Read More
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Indapamide even in very high doses (up to 40 mg, ie 27 times the therapeutic dose) and primobolan depot does not have a toxic effect. Symptoms: The symptoms of acute poisoning with medication in the first place related to the violation of water-electrolyte balance (hyponatremia, hypokalemia). From the buy primobolan depot clinical symptoms of an overdose may experience nausea, vomiting, decreased blood pressure, cramps, dizziness, drowsiness, confusion, polyuria or oliguria, leading to anuria (due to hypovolaemia). Treatment: The first aid measures total fitness control to reduce the excretion of the drug from the body: gastric lavage and / or administration of activated charcoal, followed by restoration of water and electrolyte balance. Interaction with other drugs Unwanted drug combination Lithium preparations: With simultaneous use of indapamide and drugs lithium may increase the concentration of lithium observed in plasma due to the reduction of its excretion is accompanied by the appearance of signs of overdose. If necessary, diuretic drugs can be used in combination with drugs lithium, and should be carefully selected dose drugs, constantly monitoring plasma lithium content. The combination of drugs that require special attention Drugs that can cause arrhythmia type "pirouette": antiarrhythmic drugs class IA (quinidine, gidrohinidin, disopyramide); Class III antiarrhythmic drugs (amiodarone, sotalol, dofetilide, Ibutilide); some antipsychotics: phenothiazines (chlorpromazine, tsiamemazin, Levomepromazine, thioridazine, trifluoperazine), benzamides (amisulpride, sulpiride, sultopride, tiaprid), butyrophenones (droperidol, haloperidol); others: bepridil, cisapride, difemanil erythromycin (w / w), halofantrine, mizolastine, pentamidine, sparfloxacin, moxifloxacin, astemizole, vincamine (w / w). Increased risk of ventricular arrhythmias, especially arrhythmias such as "pirouette" (a risk factor – hypokalemia). It should determine the potassium content of the blood plasma and adjust health conscious it before indapamide combination therapy if necessary and the above mentioned drugs. Necessary to control the patient's clinical status, control of blood plasma electrolytes and ECG parameters. In patients with hypokalemia is necessary to use drugs, do not cause arrhythmia type "pirouette". Nonsteroidal anti-inflammatory drugs (for systemic administration), including selective buy primobolan depot, high dose salicylates (23 g / day): Perhaps the reduction in the antihypertensive effect of indapamide. When a significant loss of fluid may develop acute renal failure (due to a decrease in glomerular filtration rate). Patients need to compensate for fluid loss and the beginning of treatment carefully monitor renal function. Angiotensin converting enzyme Appointment of inhibitors in patients with a reduced concentration of sodium ions in the blood (especially in patients with renal artery stenosis) is accompanied by a risk of sudden hypotension and / or acute renal failure. Patients with hypertension and possibly reduced due to diuretics, the content of sodium ions in the blood plasma, it is necessary: 3 days prior to initiation of treatment with inhibitor stop taking diuretics. Later, if needed, can be resumed diuretics; or begin therapy with an inhibitor with a low dose, and then gradually increasing the dose if necessary. In chronic heart failure treatment inhibitors should be started...Read More
methenolone enanthate side effects
After methenolone enanthate intake of rapidly and completely absorbed from the gastrointestinal tract; bioavailability – high (93%). Food intake slows down the absorption rate, but does not affect the completeness of absorption.Maximum plasma concentration – 12 hours after ingestion. Repeated receptions indapamide fluctuations in plasma concentrations in the range between the two doses decreased techniques. The equilibrium concentration is set at 7 days of regular admission. The methenolone enanthate side effects, connection with blood plasma proteins – 79%. Associated also with elastin smooth muscles of the vascular wall. It has a high volume of distribution, passes through the blood-tissue barriers (including placental) passes into breast milk. It is metabolized in the liver. The kidneys remove 60 – 80% in the form of metabolites personal trainer jacksonville fl (unchanged output of about 5%), through the intestines – 20%. In patients with renal insufficiency The pharmacokinetics does not change. Not accumulates. Indications Hypertension. Contraindications : Hypersensitivity to indapamide and other ingredients, as well as to other sulfonamide derivatives, severe renal insufficiency (creatinine clearance less than 30 ml / min), hypokalemia, hepatic encephalopathy or severe liver dysfunction, pregnancy, lactation, age 18 years ( efficacy and safety have not been established); concomitant use of drugs prolonging the interval. Precautions: in the human liver and / or kidney disease, disorders of water and electrolyte balance, hyperparathyroidism, in debilitated patients or in patients receiving concomitant therapy with other antiarrhythmics, while taking drugs, prolonging the interval QT (see "Interaction section with others. drugs "), diabetes, hyperuricemia (especially accompanied by gout and urate nephrolithiasis). Use during pregnancy and lactation During pregnancy should not prescribe diuretic drugs. Do not use these drugs to treat physiological edema of pregnancy. Diuretic methenolone enanthate side effects drugs can cause fetoplacental ischemia and lead to impaired development of the fetus (malnutrition). Application Tenzar drug is not recommended during pregnancy. Indapamide is excreted in breast milk. Given the possibility of occurrence of adverse events in infants fearless fitness, breast-feeding during treatment with Tenzar not recommended. Dosage and administration Capsules taken orally without chewing. The daily dose – 1 capsule 1 Tenzar drug once a day (in the morning), drinking plenty of fluids. In the treatment of patients with hypertension dose should not exceed 2.5 mg (increased risk of side effects without increasing the antihypertensive effect). Elderly patients are elderly patients should be monitored plasma concentration of creatinine according to the age, weight and sex. Tenzar drug at a dose of 2.5 mg / day (1 capsule) can be administered to elderly patients with normal or mildly impaired renal function (see. "Contraindications"), Side effects Most adverse reactions (clinical and laboratory parameters) are dose-dependent. The frequency of adverse reactions that can be caused by thiazide diuretics, including indapamide, given by the following grading: very often (> 10.1); common; very rare (<1/10000); unspecified frequency (frequency can not be calculated from the available data). From the circulatory...Read More
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Primobolan depot is used by athletes mainly in the period of preparation for competitions, largely due to lack of aromatization, and as a result, water retention. Fexofenadine slightly metabolized in liver and elsewhere, as evidenced by the fact that it is the only substance detectable in significant amounts in the urine and feces of humans and animals. in exchange taking the drug fexofenadine elimination curve primobolan depot for sale of the plasma decreases biekspotentsialno, and terminal half-life is 11-15 hours. Pharmacokinetics with a single and course intake fexofenadine (up to 120 mg twice a day orally) is linear. The dose of 240 mg twice a day gives a slightly more than proportional (8.8%) increase in the area under "concentration-time" curve, which indicates that the pharmacokinetics of fexofenadine is substantially linear over a dose range from 40 to 240 mg per day . According to most of the dose at the time of the data currently available in unchanged form excreted in the bile, and up to 10% of the drug – in the urine. Indications of seasonal allergic rhinitis (to reduce the symptoms) – Tablets, 120 mg. Chronic idiopathic urticaria (to reduce the symptoms) – Tablets, 180 mg. Contraindications Hypersensitivity to any component of the drug. Pregnancy. lactation Children's age (12 years).Carefully: in patients with chronic renal and hepatic failure, as well as in elderly patients (lack of clinical experience with this category of patients); in patients with cardiovascular disease, including a history (antihistamines can cause palpitations and tachycardia, see "Side effects" section).Pregnancy and lactation Pregnancy There is insufficient data on the use of fexofenadine for pregnant primobolan depot for sale women. Limited animal studies have shown no evidence of the presence of adverse effects on pregnancy, prenatal development, childbirth and postnatal development. Fexofenadine should not be used during pregnancy. Lactation Data on the content of fexofenadine in breast milk when taking breast-feeding women are not available. However, when taking terfenadine seen its penetration in the breast milk of lactating women. Therefore, the use of fexofenadine during lactation period is not recommended.Dosing and Administration The tablets are for oral use. The recommended dose of fexofenadine in seasonal allergic rhinitis for adults and children 12 years and older is 120 mg once a day before meals. The recommended dose of fexofenadine primobolan half life with chronic hives for adults and children 12 years and older is 180 mg once a day before meals. patients at risk Studies in special risk groups (elderly patients, patients with renal and hepatic impairment) have shown that they do not require a correction mode.Side effects: In placebo-controlled clinical trials, the most frequently (≥1% – ≤10%) the observed undesirable effects were headache (7.3%), drowsiness (2.3%), dizziness (1.5%) and nausea 1 ,5%. When receiving fexofenadine frequency of the above adverse effects was similar to that of placebo. In placebo-controlled trials with a frequency of less than 1%...Read More
bayer primobolan depot
Patients should strictly adhere to all the recommendations relating to the primobolan depot dosing regimen. The patient should be informed that the combination therapy bayer primobolan depot and ritonavir, as well as any other antiretroviral therapy does not cure . The therapy may develop opportunistic infections and other complications of HIV infection. There is no evidence that the currently known anti-retroviral drugs, including combination therapy Telzirom and ritonavir, can prevent the risk of transmission of HIV to others through sexual contact or through blood. Therefore, you should observe proper precautions. Patients who have had hepatitis B or C, or in patients with initially elevated transaminase activity, the risk of increased transaminases increased. In these patients before therapy and then, at regular intervals of time necessary to carry out appropriate laboratory studies. Since renal clearance amprenavir plays no significant role in the removal of the drug, it is unlikely that patients with renal failure is observed increase of its concentration in plasma. It is unlikely that hemodialysis or peritoneal dialysis can to a large extent withdraw amprenavir in mind the high degree of binding to plasma proteins. Hypersensitivity reactions: The drug in the development of skin rash mild or moderate in severity and in the absence of severe systemic manifestations of hypersensitivity can be continued with simultaneous application antihistamines. Severe skin reactions, including Stevens-Johnson syndrome (severe clinical kind of bullous erythema multiforme), infrequently resulting in the emergence of life-threatening, have been observed in less than 1% of patients in clinical studies. Telzir should be canceled in the event of the following symptoms: skin rash, severe; rash on the mucous membranes; skin rash of moderate severity, accompanied bayer primobolan depot by other systemic manifestations of hypersensitivity. Patients with haemophilia: There have been recorded cases of frequent bleeding, including spontaneous intradermal hematomas and hemarthrosis, in patients with hemophilia A and B treated with protease inhibitors. Some of these patients were treated with the blood coagulation factor VIII. In more than half the treated protease inhibitors was continued or resumed (in this case, if the treatment is interrupted). Thus, patients with hemophilia need to be informed about the possible quickening of bleeding.Hyperglycemia: debut Cases of diabetes mellitus, hyperglycaemia or exacerbation of existing diabetes mellitus have been observed in patients receiving antiretroviral therapy, including the HIV protease inhibitors. Correction insulin dosing regimens or oral hypoglycemic drugs used for the relief of these phenomena. In some cases, diabetic ketoacidosis has been registered. A causal relationship between protease inhibitor therapy and these events has not been established. The redistribution of subcutaneous fat: Combination antiretroviral therapy, including the HIV protease inhibitors, it resulted in some cases in a redistribution / accumulation of subcutaneous fat. A causal relationship between these events has not been established. Increasing lipid content: fosamprenavir treatment leads to an increase in the concentration of triglycerides and cholesterol. It is necessary to determine the initial...Read More
primobolan depot dosage
Other drugs Antacids: set reduction in primobolan depot dosage of amprenavir by 18% and 35%, respectively, while increasing the C min upon receipt of a single dose of 1400 mg of fosamprenavir with a single dose of 30 mL of an antacid suspension (equivalent to 2.75 g of aluminum hydroxide and magnesium hydroxide, 1.8 g). Any dose adjustment of these drugs when combined use is not required. The antagonists histamine receptors: the concentration of amprenavir in the blood can be reduced in the combined use of antagonists of H 2 histamine receptors (for example, while taking ranitidine and cimetidine). Joint reception of ranitidine (300 mg single dose) with fosamprenavir (1400 mg single dose) reduces plasma amprenavir However, the index of amprenavir remains unchanged. Dose adjustment when coadministered to any of the herein preparations are required. Proton pump inhibitors: the combined use of antacids 1400 mg twice a day and of esomeprazole 20 mg per day for 14 days increased the esomeprazole without affecting . Corrections dosing regimen in this case is not required. The drugs with a narrow therapeutic range: while the use of fosamprenavir with drugs such asamiodarone, quinidine, lidocaine (systemic route of administration), tricyclic antidepressants and warfarin requires monitoring concentrations of these drugs in the blood plasma in connection with the possibility of life-threatening conditions. For warfarin need to monitor the international normalized ratio . The following list of drugs are examples of substrates, inhibitors or inducers primobolan depot dosage, which may interact with fosamprenavir with simultaneous application. The list is not exhaustive. The clinical relevance of these potential interactions is not known or is not fully understood. In this connection it should pay special attention to monitoring the toxic effects of these drugs while their reception with fosamprenavir. Alfuzosin: Serum concentrations may be increased, which may lead to an increased risk of arterial hypotension. Anticonvulsants co-administration of anticonvulsants, inducers of enzymes ( phenytoin, phenobarbital, carbamazepine) with fosamprenavir without the concurrent use of low-dose ritonavir may reduce the concentration of amprenavir plasma. Benzodiazepines (alprazolam, clorazepate, diazepam, flurazepam) may increase their serum concentrations that can lead to an enhancement of their activity. calcium channel blockers (amlodipine, diltiazem, felodipine, isradipine, nicardipine, nifedipine, nimodipine, nisoldipine and verapamil) may increase their serum concentrations that can lead to an enhancement of their activity and toxicity. It is recommended to monitor the concentration of these drugs in the blood. Dexamethasone: may induce the isozyme or decrease in the plasma concentration of amprenavir. Inhibitors of phosphodiesterase-5: concentration of sildenafil in plasma can rise significantly, while the application antacids, which may increase the incidence of adverse reactions and other inhibitors sildenafil fosfodiesterazy- 5 (hypotension, blurred vision, priapism). Concomitant use of antacids and sildenafil, vardenafil is not recommended. Fluticasone propionate (interaction with ritonavir) has been shown a significant increase in serum concentrations of fluticasone propionate, while the use of 200 mcg of fluticasone nasal and 100...Read More
Exercise after a cold
During the year each person one or more times migrates colds. Athletes are no exception. Lovers are susceptible to a much greater extent than professionals devoting their health attention. This does not mean that they do not get cold at all. Even hurt Champions. The state of health worsens, the body is depleted and, consequently, to return to training during the recovery period should with caution. Why not train with a cold? The body of any person during colds weakened. Lowered immunity becomes vulnerable to any viruses, and physical activity even more aggravate the situation. Continuing to engage in a morbid state, the athlete puts themselves under attack, as it is able to trigger the development of more serious diseases. Flu in the initial stages are easily mistaken for the common cold. This is a rather dangerous condition in which physical activity has a negative effect on the heart muscle. Athlete going to training symptoms of a cold, risking not only productive employment but also their health. It is best to postpone the exercises. How to resume training after a cold? Doctors do not suggest to return to training after illness. It is recommended to wait at least two or three days, and then again to start. This allows to exclude risks of recurrence of cold to fully recover. In the first days after disease continue to drink plenty of warm fluids and vitamins. Proper nutrition plays a vital role in maintaining and restoring the body. Athletes experience never get to practice as usual immediately after a cold. First, it performs light exercises with low intensity. The load increases gradually, that is, from occupation to occupation. If you ignore such a transitional period, starting to train on the same program that was before the illness, the likelihood of exhaustion and a recurrence of colds increases. The first few workouts can be done at home and not in the gym. Just enough to engage with their own weight. This will help to remind the body that rested on the necessity of physical development that will prepare for more challenging training. First class after colds Attention it is recommended to warm-up and workout. Well suited Vysokogornaya exercise program with small weights, cardio, but only slight. This mode will not cause high stress will cause a good sweat to prepare the heart muscle and the circulatory system to the more intense classes. The first days you can jump with a rolling pin, squat, do push-UPS, chin-UPS, run on the treadmill. To do better upryamo home. When the physical condition and health is restored, move on to more high loads and strength training. It is important not to lift a weight similar to the one you worked with before cold. Spend first two preparatory exercises. In the first session, take a weight 50% of which generally falls to the athlete, the second at...Read More
Andropen 275
The drug Andropen 275 is a steroid with anabolic and androgenic effects. This mixture of esters of testosterone produced by British Dragon Pharmaceuticals, has a prolonged effect, due to gradual separation of the steroid coming into the bloodstream, from the corresponding ether. Specific features long-lasting effects and Deposit Andropen give it air. Having the form of a hydrocarbon chain, it joins a molecule of anabolic steroid action. The creation of the esters made it possible to solve the problem of frequency of injections. On the injection of anabolic essential basis appears the oil depot. It is a source of supply of blood steroid. The speed at which the "return" depends on the half-life of the broadcast donde comprar testosterona. In Andropen 275 combined multiple esters having different half-life. This provides continuity of income testosterone up to the moment until I finish act decanoate. Andropen has diverse positive effects on the body of the athlete. It helps to strengthen the immune function, normalizes the nitrogen balance, increases strength and muscle growth. Developed specifically for sports, it is widely used by weightlifters, bodybuilders, powerlifters and power extreme. What is the impact of receiving steroid Andropen 275 Injections have the following effects: allow to gain maximum possible muscle mass from testosterone; increase the strength and endurance of an athlete; strengthen and improve the functionality of the ligaments and joints, relieve pain; increase appetite and accelerate the metabolic rate; improve overall health and strengthen the immune system; normalize the nitrogen balance; enhance libido on the course; increase motivation. the Andropen is composed of five different testosterone esters, each of which has a half-life. Acetate it is the day, that is after 24 hours, the concentration starts to decrease two times when half the active substance is excreted from the body, the propionate — two, phenylpropionate — four, cypionate is eight, and decanoate twelve days. How to take Andropen? A course of steroid lasts up to six months, and the optimal weekly dosage is 300-600 milligrams. Injections are made once every seven days, which is a huge advantage of the drug. Women to use Andropen is not recommended. This reflects both the high capacity of a mixture of testosterone and the possible manifestation of virilization. To strengthen the effect of muscle volume, which allows the joint taking the drug and Methandienone and Stanozolol, which starting to drink shortly before the end of the course, allowing you to get the maximum result. Thanks to a regimen of steroid, after the drug is no Hairdryer rollback. For post-cycle therapy it is recommended to use Tamoxifen or Clomid and Gonadotropin. Possible side effects from taking Andropen 275 Adverse effect of injections of steroid appear, as a rule, those athletes who improperly came to the beginning of the course of the drug. If you exceed the dose stipulated in the instruction to disregard the duration of the course...Read More
Protein for drying body
Some sports supplements are designed to improve the process of training, to enhance the effect of weight loss and muscle mass. The most popular type of sports nutrition are considered as protein complexes. They are used for muscle growth, and the drying period. Each protein has its own characteristics, advantages and some drawbacks. It is necessary to consider exactly what kind of facility brings the greatest benefit during drying, and which protein is considered the most preferred how useful protein shakes to lose weight. The drying period requires a change of diet, ie, lower calorie diet. It is, first and foremost, becoming a major cause of protein deficiency, which should not in any way be allowed as it leads to health problems. Lack of protein leads to disruption of metabolic processes, decrease in immunity, deterioration of hair and skin. Can develop even disorders of a psychological nature. Protein deficiency leads to a reduction in protein. This starts the destruction process, which consists in burning muscle mass and to stop fat burning process. To avoid such negative consequences, you should keep up the protein and even when the lifter wants to get rid of excess fat, taking a protein during drying. How to drink protein on the drying? Many nutritionists and experienced athletes are of the opinion that a day needs to consume about 2 grams per 1 kilogram of body weight. Protein is recommended to be taken in the morning, before and after training, between meals. Use casein can and before bedtime. To cook a batch of cocktail, you should not take more than one measuring spoon. The drinks don't need to add honey, sugar, jam, fruit. Similar ingredients instantly increase the caloric content of the upcoming beverage. To get the maximum benefit from the protein drying allows taking into account the following aspects: In the morning the athlete's body is experiencing the greatest shortage of nutrients. The best choice for the replenishment of protein in the morning will be protein serum with a high rate of speed assimilation with high-quality amino acid composition. Drinking protein shakes in the morning a must, as it allows you to stop the catabolic processes. and a Protein required for training, and after the end of classes. Otherwise the athlete will not be able to maintain muscle mass. Thanks to the whey protein that is quickly absorbed in the body, muscle fibers and cells are preserved. to Take protein protein before bed is also important. They provide the muscle power almost overnight. To overcome night catabolism, should be consumed casein, has a much longer validity period. By following these recommendations, you can avoid losing muscle mass, getting rid of fat. What other supplements to take to dry? Proteins are not the only additives which are necessary for the athlete. Should use BCAA and effectively as opposed to catabolic processes, with a minimal calorie...Read More
Heart rate during workouts
Control your own pulse during exercise is one of the best ways of monitoring the degree of intensity of the performed exercise. Most athletes do specifically with the heart rate monitors that is not mandatory. It is sufficient to use a simple stopwatch or to monitor the pulse on the clock in the gym. What are the benefits an athlete by measuring heart rate (heart rate) does not matter, more importantly, what should be the pulse on exercise. How to calculate heart rate for sports? The conventional calculation formula is to find upper and lower bounds of the heart rate. This means that efficient is a workout, during which the pulse is within the boundaries of these two markers of heart rate. The lower bound is calculated as follows: the number "200" take the age of the athlete, and multiply it by the figure "0,6". If a trainee athlete 25 years, that is 105 beats per 1 minute. To do when the pulse is below this value is not recommended because the benefits of exercise will be minimal. The upper bound is calculated by a similar formula. The difference is that instead of "0,6" use factor "of 0.8", i.e., for the 25-year-old athlete, the figure is 140 beats per 1 minute. To go beyond the upper boundary of the heart rate is not recommended because it causes increased load on the heart muscle. Athletes do not always take into account factors when finding the upper and lower limits, as they prefer to do the maximum. They train to the limit from 170 to 180 beats per 60 seconds even taking into account that it is much higher if you subtract from maximum allowable value of 220 own age. And if the pulse reaches such limits should reduce the intensity of your workout. Otherwise it is likely to harm their health. To make it easier to navigate, not doing endless calculations, you can just use the table given below, following which you can easily control the heart rate when varying degrees of exercise intensity. Heart rate during cardio workouts The pulse is measured with a stopwatch while running, it is virtually impossible. And if the sportsman is fond of cardio, then he should buy a heart rate monitor for running on the street to use built-in exercise bike and treadmill control devices. When the goal of cardio is to burn body fat, heart rate should be between 120 and 150 beats per minute. Bodybuilders should follow a slightly different scheme to preserve muscle. Cardio should be low intensity, that is, within classes with a duration of 50-60 minutes, the heart rate should be in the 120-130 beats. Pulse on power training Experienced athletes is not recommended to bring your heart rate to the upper limits. The ideal heart rate is an upper limit of 120-140 beats per minute, persistent from...Read More
Can I eat carbs after a workout?
Everyone who plays sports knows that at the end of the training there is a strong desire to eat cookies, banana, chocolate, drink fizzy cool drink. There is no doubt that fast carbs after a workout play an important role in the recovery process. In fact, all is not so simple and obvious. The best time to consume carbohydrates is it is the period after exercise when the muscles instantly absorb nutrients. This does not mean that you can afford to eat chocolate, marmalade, chocolates, biscuits. Do you need carbs after a workout? Physical exercises require a lot of glycogen. Expended stocks of the substance that needs to be filled immediately. Here and out fast carbs, eat that at the end of the training, of course, necessary. However, given some peculiarities of this substance, to approach post-workout diet should be quite cautious. Otherwise, instead of a positive effect, you can get quite a different result. What is the number of calories burned per hour workout? The answer to this question and allows the athlete to clarify a nuance about how useful it is to consume simple carbohydrates during the recovery period after exercise. According to the research, even the most hard training lead to the burning of about a quarter of the reserves of muscle glycogen. The amount in muscle is about 400, and in the liver — 100 grams. High intensity interval training and exercise with large weights, has been shown in one study not increase the cost of muscle glycogen. Thus, regardless of the type of exercise, burned the same amount of calories. The degree of intensity of training does not depend on the load and requires the same amount of carbohydrate to fill. The amount of glycogen must be the same consumed calories. And if, after completion of the training, to eat, for example, the chocolate ice-cream or candy bar containing 10-50 grams of carbohydrate to replenish depleted stocks is not allow. Carbohydrates are not the only source of energy During intense workouts are depleted and fat stores. Particularly active in the process of weight loss appears when performing high-intensity training. One of the studies showed that the exercises with weights burns about thirty percent fat, and muscle glycogen is twenty — eight percent. If you do not take into account a quick snack with carbohydrates immediately after exercise, muscle glycogen to fill needs about twenty four hours. And, given this fact, it becomes clear that when performing light exercise or an intense hour of training per day, time to replenish carbohydrates abound. And to have a beautiful, physically developed body from simple carbohydrates after a workout should be avoided. The best option would be the distribution of food rich in carbohydrates during the day, which will fully cover the spent glycogen, to have the necessary supply of this substance for post workout and all day....Read More


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by Steve Lancaster 8/26/17
True Detective is available on Amazon or as part of your HBO subscription. • True Detective should be much better than it is. I had previously avoided watching this 2-season series. In part, because I dislike Woody Harrelson as an actor. I find him one-dimensional and stiff. In that regard True Detective, was a minor surprise. Harrelson is not as wooden and stiff as in other movies; like No Country for Old Men, Planet of the Apes, and the Hunger Games, to mention a few.
McConaughey, on the other hand, almost always develops a complex character, struggling with his own demons and not always winning. He has made better movies; Interstellar, Dallas Buyer's Club and Lincoln Lawyer come to mind. The primary writer is Nic Pizzolatto a Louisiana native with credits for the Magnificent 7, crime novels and short stories. My deciding factor was Pizzolatto had taught literature at the University of Arkansas. And, a well written crime story is hard for me to resist.
However, it was mixed feelings that I started True Detective. The first episode and others following until about half way though are composed of flashbacks and flash forwards, at first it is a little fragmented. The flashbacks cover a time period of about 20 years. From the time Detective Rust Cohle (McConaughey) and Detective Marty Hart (Harrelson) are pared as partners to their current endeavors as private citizens. Cohle is a part-time bartender and working alcoholic and Hart is a PI.
Cohle and Hart are interviewed in the current time about a previous case they had worked on and thought to have solved involving cult-like serial murders in the low country around Baton Rouge LA. As the story develops we learn that Cohle had been an undercover narcotics agent in Texas and was hired by Louisiana State Police when his cover was blown. He is presented as the cerebral part of the partnership, called the "accountant" by other detectives because he is so straight. One suspects that the rigidness of Cohle is the after effect of PTSD. Hart is much more gregarious and well respected by his fellow detectives and superiors.
The case involves the murder of a woman. The woman has been tied to a tree in a cane field in ritual fashion, kneeling with symbols drawn on her naked body and antlers tied to her head. Even for Louisiana this is considered a bit odd. The investigation, still involving flashbacks and flash forwards, takes the detectives to the fringes of Cajun and rural culture. We're not talking the good old boys of Swamp People, alligator hunters like Troy Landry. But the hardened people who never leave the swamp and are not friendly to anyone from off.
The case also has leads to some of the political and social elite of Louisiana, however, that part of the investigation seems to be going nowhere. As the middle episodes expand the investigation focuses is on a previously convicted criminal and relative of a local sheriff. As the story progresses the detectives develop a case and attempt to arrest the perp. That effort has consequences, they find children hidden in a barn. Hart is so outraged at how the children have been abused and readied for sacrifice that he executes the perp when Cohle has him handcuffed.
The detectives, cover the murder by staging an elaborate shoot-out in which the perp is killed. Their reports are similar enough and the perp nauseating enough to close the case. The last part of the series deals with current day, no more flashbacks.
As the police interviews end for Hart and Cohle, both realize that there are strings to this case that they did not pursue. They partner up, this time under Hart's license as a PI. They again follow leads that travel to the upper crust of political and business in Louisiana. They find a perp, with ties to this upper crust and ties to the crimes. Both men are wounded bringing the perp to the law and the perp dies in the resulting shoot out, this time justified. However, we are left with the feeling that much more could be investigated, but won't.
On the plus side both detective's characters are developed and altered by the events of this story. Hart becomes more analectic and less emotional Cohle retreats into a bottle, showing more symptoms of PTSD. That they can team up in the present day is remarkable and demonstrates some excellent writing. On the minus side. Well, it's always the rich and powerful that get away with it, isn't it? However, it was overall a good crime story, well written and acted.
The second season changes the location to LA in the present day with Rachel McAdams and Colin Farrell. Harrelson and McConaughey are listed as producers. I watched 3 episodes just to get a feel. In a word, terrible. It is a waste of photons on your 48" big screen. • (428 views)

subset: commoncrawl


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I worked on this over the first half of this term, too. The brief required for the inclusion of specific headings, text and logo placement. As well as bright and bold visuals, intended to be informative and persuasive.
The brief also called for an awareness and consideration of the development of other forms of advertising and uses of the main graphic image.
My final poster design submission. The two typefaces were developed from previous commission work, but cleaned up and tweaked slightly. A return to typeface generation after a fair few months meant that they aren't perfect, but work OK. I wanted to demonstrate the audience of the survey in the graphic, as well as emphasise the message of the tagline. I went for the brain (the vessel of opinions) shining like a chest-full of treasure. Perhaps this would have been communicated more clearly if I had used yellow, but I wanted to maintain a colour scheme from previous posters which echoes the surveys logo, as well as that of Ipsos MORI. I also just wanted to bring a bit of fun to what is quite a mundane, though beneficial task.
A rough design for a web banner. I also proposed how this might be animated.
A rough wallpaper design, to be used on computers at institutions which take part in the survey.
More recently, over the last week or so, I've worked on another poster.
A commission from the University of Nottingham Christian Union, to produce a poster for a Christmas themed pub quiz. They supplied the event title and critical information, but the design of the poster was left down to me. Free work, of course. My girlfriend studies at Nottingham and mentioned my availability. Quite handy for them, as the University doesn't have any design courses to call upon!
Festive colour schemes and themed fonts. A bit of experimental play really. I'm not sure whether or not I had worked out a decent composition, but I was trying to finish the project quite quickly.
Just a quirky illustration highlighting the quiz and the inclusion of a free mince pie. Some stylistic elements inspired by Jim Field.