text:
Personal Trainers in Athens, OH
Fitness doesn't need to be difficult and there's no one way to get fit for everyone. Everyone's goals, genetics, time, and circumstance is different. At Modern Fit we have brought together fitness coaches in and near Athens that are focused on helping you achieve your fitness goals. Along with a comprehensive coaching routine, our coaches provide meal plan tips and can work with you in person and online.
We have trainers in Athens that fit your needs no matter the time. It isn't necessary do thousands of pullups or burpees or run hundreds of miles to reach your fitness goals. Modern Fit coaches will plan a realistic program so you can actually reach your fitness goals without a drastic and painstaking lifestyle change. they will track your progress and eating habits to find a routine that meets you and your daily life, even if you only have a few spare moments each day.
Athens has tons of fitness centers and coaches that are hoping to sell you basic and expensive training sessions. Most of the trainers you'll meet train a variety of different clients with drastically different objectives so they won't be able to really adhere to your needs. At Modern Fit, we only have the best, most passionate trainers that you can personally pick at an inexpensive price.
So join us and get fit with our Modern Fit Athens trainers, where we take your wellness personally. Search our personal trainer and athlete database or easily shoot us a message below and we will be sure to locate your perfect fitness coach.


text:
One stock teaser I've come across a lot over the past several months is one by Dylan Jovine dubbed "The End of Alzheimer's."
According to the Behind The Markets website, a "tiny biotech" has come up with a "new way to treat Alzheimer's," and Jeff Bezos (among others) has invested in it.
Dylan Jovine likens investing in the company to backing Reed Hastings when he started Netflix, Howard Schultz who started Starbucks, or Tesla's Elon Musk. He also suggests it's one of the biggest opportunities he's seen in his almost 30-year career in finance.
What company is Jovine teasing?
And what treatment has it supposedly come up with?
That's what I wanted to know, so I looked into Jovine's pitch to see what I could find. And in this post, I'll show you exactly what I discovered – ticker and all.
Unpacking the "End of Alzheimer's" Teaser
Dylan Jovine began the presentation by talking about a scientist who he says told Jeff Bezos "three words" and walked out with a check for $130 million.
According to Jovine, these three letters, which all start with "B," could change how we treat one of the "cruelest diseases on Earth," minting millionaires in the process.
"In May 2015, Fidelity Biosciences cut him a check for $217 million.
In August 2016, he told Jeff Bezos three words. He walked out with a check for $130 million.
It took just over a year – 390 days – for this company to hit a $1 billion valuation. That's faster than any company in history, including Facebook.
All because of three words. Words that all happen to start with the letter 'B.'"
"These three words could do more than just make you rich.
They can change how we treat one of the cruelest diseases on Earth.
And that means it could mint as many millionaires as other big winners started by visionary entrepreneurs."
As the presentation continued, it became clear that the disease Jovine was talking about there is Alzheimer's, a type of dementia that affects memory, thinking, and behavior.
And according to Jovine, the "three words" he mentioned hold the key to a new treatment that Jim Cramer said would be "the biggest drug ever, which he says experts predict could help millions of people while potentially saving the U.S. trillions in medical costs.
"It's because the three words hold the key to a new treatment Jim Cramer says would be 'the biggest drug ever.'"
"A treatment that experts predict could help as many as 50 million people…and save the United States $20 trillion in medical costs."
Jovine shared the above Cramer quote numerous times throughout the presentation, so I looked into it because I was curious to know what exactly it related to. And it turns out he's citing a Jim Cramer quote about Biogen's Alzheimer's treatment.
However, Biogen does not appear to be the company Dylan Jovine's teasing. Instead, the clues suggest he's tracking a smaller biotech company.
But before we get to that…
What "three words" is he referring to?
According to Jovine, he's talking about the Blood-brain barrier:
"What are the three words that could be worth $20 trillion?
The three letters are 'B-B-B'…
It stands for 'Blood-Brain-Barrier.'
And as you're about to learn, these three letters could create the 'biggest drug in the world.'"
I'm not a medical expert (by any stretch of the imagination), so I'm not even going to attempt to explain what the blood-brain barrier is or how it relates to Alzheimer's disease. But for the sake of breaking down the presentation, I'll summarize how Dylan Jovine described it.
In short, Dylan Jovine said in the presentation that the blood-brain barrier stops the majority of drugs from getting to the brain and that the company he's recommending has developed a "Trojan Horse" that sends a signal to the blood-brain barrier, letting it through.
"The challenge in treating Alzheimer's isn't necessarily the lack of drugs.
It's that you can't get those drugs to reach the brain.
You see, the Blood-Brain-Barrier stops 100% of large-molecule drugs from getting to the brain.
Small-molecule drugs only fare slightly better. 98% can't make it past the Blood-Brain-Barrier."
"How do we ever cure Alzheimer's when our drugs can't even reach the brain?
Today's company does just that…
It's developed a 'Trojan Horse' that sends a signal to the Blood-Brain-Barrier to let it through."
The actual way this company's treatment works is no doubt far more complex than that, but at least that's an explanation that's easy enough to grasp.
And according to Dylan Jovine, what this company has developed is a "sea change" compared to what's currently on the market.
"By making it to the actual brain, these drugs can begin the process of treating the disease itself.
That's a sea change from the Alzheimer's drugs currently on the market."
What's more, Jovine said that the company he's teasing has a patent on what "could be the biggest drug in the world" and that it has a "strategic partner."
"My research has led me to a small company has the one thing that matters the most: a patent on a drug that could be the biggest drug in the world.
And they have the two other key ingredients: a strategic partner and a massive market."
In the next section, I'll show you what company I think Dylan Jovine is teasing and how it matches the clues he shares in the presentation.
What Biotech Company Is Dylan Jovine Teasing?
Aside from talking about the company's treatment, the two biggest clues Dylan Jovine shared about his pick were a photo of the company's CEO and hints about who has invested in it.
"A U.S. Big Pharma giant invested $1 billion and got an 11.2% stake.
French Big Pharma giant Sanofi invested $125 million.
And Japanese Big Pharma giant Takeda Pharmaceutics invested $150 million."
The first thing I did was use Google's image search to see what came up for the photo Jovine shared, and it turned out to be a photo of Ryan Watts of Denali Therapeutics.
From there, I looked at Jovine's other clues, and they appear to match Denali.
Well, according to the website, Denali Therapeutics develops medicines to defeat neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS (among others). And the company site says they've "engineered a proprietary technology to deliver biologic therapeutics to the brain."
I'm not sure exactly what patent Dylan Jovine was referring to in the presentation, what drug it relates to, or how significant it is. But I did find a list of Denali Therapeutics patents on justia.com that might shed some light on that if you want to research this further.
Also, the company's 2022 Corporate Overview PDF discusses its development portfolio and what it's working on regarding the blood-brain barrier (BBB) side of things. So that may be worth a look if you want to get some clarity on what "treatment" Jovine's referring to.
As for the companies Jovine claims have invested in Denali Therapeutics, the clues about Sanofi and Takeda match. And the "U.S. Big Pharma giant" he's referring to appears to be Biogen, which according to investors.com, committed over $1 billion as part of a collaboration with Denali that also involved it taking an 11% stake in the company.
As for Jovine's clues about Fidelity Biosciences and Jeff Bezos… what he said about Fidelity Biosciences appears to match. And a September 2021 New York Daily News article states that Jeff Bezos "holds stakes" in several startups, including Denali. Although it's unclear exactly how much Bezos invested in the company.
In any case, Denali Therapeutics (DNLI) looks like Dylan Jovine's pick.
If you want to know for sure, however, Jovine has put together a report detailing his pick called "Past the Blood-Brain-Barrier: The Small Company Revolutionizing Alzheimer's Disease." And that comes with a subscription to Behind The Markets.
Recommended: Go here to see my #1 rated stock advisory of 2024
What Is Behind The Markets?
Behind The Markets is a stock advisory service run by Dylan Jovine, and this is also the name of the company he founded that publishes the service.
The service focuses on long-term value investments in companies Dylan Jovine believes are trading at a discount to what his analysis suggests the underlying business is worth.
According to the company website, his recommendations usually focus on mid-cap companies with a market capitalization of $1 billion to $10 billion. And the site says he focuses on businesses that he and his team believe have suffered a "temporary setback," where the stock price had traded down to a more "reasonable" price level.
As a subscriber, you get one new stock idea from Dylan Jovine each month for 12 months across a variety of sectors. And the model portfolio shows you what stocks he's recommending, at what price, and when he recommends selling.
You also get access to research reports he's created on the different companies he recommends, including the "Past the Blood-Brain-Barrier" report I mentioned earlier. And Jovine provides subscribers with regular updates on his recommendations.
How much does it cost?
How much a subscription to Behind The Markets costs seems to depend on where you join (and when), but as of writing, you can join the service for $79 through the presentation.
I've put together a complete review of Behind The Markets if you want to know more, but that's the gist of what the service is about.
Who Is Dylan Jovine?
Dylan Jovine is a former money manager and founder of Wall Street private equity firm Lexington Capital Partners. He's also the founder of Behind The Markets, LLC, a company that sells numerous research services, including the one we just discussed.
According to the company website, Jovine began his career in finance in 1991, working for a Wall Street investment banker.
And in 2004, he started a financial publishing company called Tycoon Publishing, which was later acquired by Agora, a company that owns many independent publishers.
Today, Jovine shares his investment insights, and stock picks with subscribers of the different services he runs on the Behind The Markets website.
He doesn't just recommend biotech stocks, either. Before this, I covered a presentation he released about his "5G Arrow" stock pick, which centered around a tech company. So if you want to get an idea of what other companies he researches, check that post out.
Bottom Line
Dylan Jovine's "The End of Alzheimer's" stock teaser centers on a biotech company that has apparently come up with a "new way to treat Alzheimer's."
It's unclear exactly what "treatment" he's referring to or how significant it is, but the clues in the presentation suggest that the company he's teasing is Denali Therapeutics (DNLI).
As for whether or not you should join Behind The Markets, that's something only you can decide as it really depends on your goals and preferences. But it looks like a legitimate, potentially worthwhile service from what I can see, especially for the price.
That said, there's no guarantee that Dylan Jovine's stock picks will make you money. Regardless of how exciting the potential may seem, nobody has a crystal ball.
Anyway, that's my take on all of this. Thanks for reading. And if you have any thoughts you'd like to share about Jovine's presentation, leave a comment below.

subset: commoncrawl


text:
Kudos Spa Cleansing Soap contains nourishing extracts and essential oils for soft healthy skin. Designed for stylish contemporary in room experience, this refreshing collection has been created using the finest ingredients.
Key Features:
- White tea with 2x the antioxidants as green tea repairs and protects skin from free-radical damage.- Cucumber used for its anti-inflammatory properties and tones, softens and hydrates skin- Vegetable-based soap to retain skins moisture- Paraben free to minimise skin irritations- Cruelty Free- Green tea based fragrance blended with notes of Bergamot, Lemon, Freesia, Jasmine and Sandalwood.
© 2023 Cleaners Supermarket Pty Ltd. All Rights ReservedThe Extra Ordinary Cleaning Supplies Shop in NSW Australia Since 2003


text:
Effects of progestogens on the neuroendocrine system of an invertebrate model species (Lymnaea stagnalis)
István Fodor1, Zita Zrínyi1, Réka Svigruha1, Éva Molnár1, Péter Urbán1, Pei-San Tsai1, Joris M. Koene1, and Zsolt Pirger1
1 Adaptive Neuroethology Research Group, Department of Experimental Zoology, Balaton Limnological Institute, MTA Centre for Ecological Research, 8237Tihany, Hungary
2 Bioinformatics Research Group, Szentágothai Research Centre, University of Pécs, 7624Pécs, Hungary
3 Department of Integrative Physiology and Center for Neuroscience, University of Colorado, Boulder, United States
4 Department of Ecological Science, Faculty of Science, Vrije Universiteit, Amsterdam, the Netherlands
In the era of globalization, the production and consumption of pharmacologically active compounds have been constantly increasing. One of the most prevalent group of these pharmacons is the oral contraceptives (progestogens and estrogens). Their presence in freshwaters can be originated from their widely usage and low bioutilization, and the lack of the adequate wastewater treatment technologies (which are still not suitable to eliminate all kinds of pollutants). Although their concentrations are generally low (ng/L) in surface waters, their continuous and simultaneous presence can exert different invertebrate and vertebrate aquatic species. Since these contaminants mainly impair the reproductive processes of the animals, the use of molluscan species including the freshwater pond snail (Lymnaea stagnalis) seems to be a logical choice for studying their effects. Central and peripheral nervous and neuroendocrine systems of this invertebrate model species are well-characterized from key molecules to behavioural processes. Our general aim was to reveal the progestogens-induced effects on the neuroendocrine system of L. stagnalis. We examined the alterations at molecular (reproduction-mediating key molecule(s)) and individual (male sexual role) levels. To this, specimens of L. stagnalis were exposed to chronic treatment of progestogen mixtures (progesterone, drospirenone, gestodene, levonorgestrel) applying environmental relevant concentration (~ 10 ng/L). Using quantitative real-time PCR, we determined that corazonin expression decreased in the central nervous system after progestogen treatment. The main change in the male sexual function was the decreased sperm number just like in case of human population where this phenomenon has just emerged to a global problem. Despite all that, the potential offspring increased (manifested in increased number of fertilized ova in egg masses), while the quality of egg masses decreased (e.g. increased number of dead embryos, polyembryony). For summary, progestogens in surface waters exert the neuroendocrine system of L. stagnalis even at ~ 10 ng/L environmental relevant concentration. The sperm number decreasing effect of progestogens cannot be interpreted as an independent ecological risk at population level, however their overall effects definitely pose a risk. This work was supported by National Brain Project (No. 2017-1.2.1-NKP-2017-00002)


text:
our products
Blu Technologies is the authorised distributor of effective and green sustainable aquarium equipment and consumables below, to provide solutions for:
Remove Animal Smell and Contaminants – AtmosAir B-ipolar Ioniser
Animal exhibits and/or aquariums may develop unpleasant odour from uneaten food, unclean aquarium filters, animal dander and faeces. AtmosAir bi-polar ioniser is proven in removing animal and chemical smell, disinfect air and surfaces, without harmful by product such as Ozone. It also reduces Coronavirus by more than 99%. Click Here for more details.
Chemical Free Cleaning – Tersano SAO
Stabilised Aqueous Ozone (SAO) is a chemical free sanitiser and disinfectant, which is safe for cleaning animal areas as it eliminates contaminants such as E.coli, Salmonella, mould, and even reducing SARS-Cov2 virus by 99.999%! Click Here for more details.
Nanotech Bio-Media - Maxspect
Highly compact, porous and inert ceramic beads, manufactured to effectively house diverse bacterial colonies, and will not decompose by colonies growing within it.
Affordable Quality Aquarium Salt Mix – Marinium
Marinium Synthetic Sea Salt is a reliable salt used for marine aquariums to house fish, algae, corals and crustaceans. It is enriched with vitamins, various trace elements and dechlorinator. All ingredients are carefully selected, ensuring absence of pollutants such as phosphate and nitrate. It is ideal for long term use with high buffering compound to cater for sudden pH and alkalinity decline.


text:
Hard work was already done, says England boss Southgate after rout of San Marino
England, runners-up to Italy in this year's Euro 2020 tournament, ran riot in Serravalle with Harry Kane filling his boots again to make it seven goals in four days for his country.
England manager Gareth Southgate praised a job well done after his side booked their place in a seventh successive World Cup finals with a 10-0 hammering of San Marino on Monday.
They ended Group I six points ahead of runners-up Poland with 39 goals scored and only three conceded and while San Marino were pitiful opposition, Southgate said the hard work had already been done to reach next year's Qatar showpiece.
"The qualification was earned away in Budapest, Warsaw and Albania," he told ITV Sport.
"I have to credit all our players and staff for a very good year. We cannot do anything about the level of opposition but the mentality and the way they applied themselves was terrific."
England, runners-up to Italy in this year's Euro 2020 tournament, ran riot in Serravalle with Harry Kane filling his boots again to make it seven goals in four days for his country.
He struck three times against Albania in Friday's 5-0 win that left England needing only a point against San Marino, the world's worst international team, to guarantee top spot.
Kane went one better on Monday, scoring four times in the first half, including two penalties, to make it an England record 16 for the calendar year and reach 48 overall.
He is now joint third with Gary Lineker on the all-time list and only five goals behind record scorer Wayne Rooney.
"If we left him on another half an hour, we would have had Wayne Rooney's family on the phone," Southgate said of the striker's substitution in the second half.
"He is a phenomenal goalscorer, we wanted to give him the chance tonight and he took it well."
Southgate now has a year to wait before the start of the World Cup and selecting his squad will not be easy, such is the prolific talent at his disposal.
"I haven't really thought that far ahead, we have had 19 matches this season and there is so much to take in," Southgate, whose side have won more games (15), scored more goals (52) and kept more clean sheets (14) in 2021 than in any other calendar year in their history.
"This is a good opportunity to look at the last few months and what experience the younger players need before the World Cup."


text:
Social services directors must establish adult social care in the wider health and wellbeing context to meet the rising demand for services from a growing elderly population.
Anne Williams, president of the Association of Directors of Adult Social Services, told delegates to look to the NHS, voluntary sector services and to colleagues across the council to help provide more services in the community.
In Williams' keynote speech at the National Children and Adults Services conference, she emphasised the importance of developing "corporate and wider partnerships, wellbeing strategies and reablement" to meet the demand.
By using budgets outside of adult social care, councils would no longer have to tighten their eligibility criteria to meet the financial pressures of a growing population aged over 80 and more people with long-term conditions, she added.
"There are huge opportunities for us here, and unless we grasp them and see social care in this wider context, we will be driven to provide ever-increasing, intensive services to fewer people," said Williams.
More information
Association of Directors of Adult Social Services


text:
Module 1
Brief description
Diseases of the brain are common, serious and cover diseases, such as stroke and Dementia as well as autoimmunity disease and inflammation of the brain. Especially in an aging population such as Saxony-Anhalt brain diseases occur more frequently. An important feature is that they are all associated with inflammation responses. Therefore, understanding of the regulation and function of these disease-specific neuroinflammatory processes is the key to reach a better prevention and therapy of each disease in the brain.
Neuroinflammation can cause or impair a brain disease, e.g. the autoimmune disease multiple sclerosis and in later stages of the Alzheimer neurodegeneration. Otherwise, neuroinflammation can prevent the brain from damages, e.g. during infections and stroke. Interestingly, neuroinflammatory reactions are disease-specific and show an intensive alternating regulation of brain cells (astrocytes, neurons, microglia) with cells of the immune system. Particularly, this largely limited characterized interaction of brain cells with immune cells during diseases of the brain will be analyzed in module 1.


text:
Crystal Palace face another difficult test this weekend as they host Wolverhampton Wanderers in the Premier League.
The visitors to Selhurst Park tomorrow (Saturday) have started the season well, picking up 12 points from their opening seven games to sit ninth in the table; five points and four places above Palace.
And ahead of the game we spoke to the Express & Star's Wolves correspondent Jamie Brassington to get the lowdown on Nuno Espirito Santo's side.
What have you made of Wolves' start to the season?
They've made a seamless transition from their Championship-winning campaign last year to life in the Premier League.Holding both Manchester clubs to 1-1 draws has showed they can mix it with the best.
Nuno's men have grown in confidence in each game since their slightly shaky draw on opening day with Everton.
I doubt even the most optimistic of Wolves fans would have believed they would sit just three points off the Champions League spots at this early stage.
What was the summer business like - and how have those new players settled in?
Simply put - remarkable. They brought in Portugal No.1 goalkeeper Rui Patricio on a free transfer and midfielder Joao Moutinho - Portugal's third-most capped player ever - for a snip at £5million from Monaco. Both have bags of experience and have taken Wolves up a level.
Adama Traore was a club record signing for £18million and has been a real game-changer from the bench so far with his terrifying pace. Alongside Raul Jimenez up front they have settled in well. Add to that a £12m Leander Dendoncker, who cant even get a place on the bench at the present moment.
Wolves also tied down Diogo Jota, Willy Boly, Ruben Vinagre and Leo Bonatini on permanent deals.
What is the current mood among supporters - and what do you think is a realistic aim for Wolves this season?
Cloud nine. Heaven. The fans still have to pinch themselves at what they are witnessing at Wolves and where the club has gone over the last two years.
All this is thanks to their owners Fosun and the managerial expertise of Wolves boss Nuno Espirito Santo, who has revolutionised the way his team play, train, analyse and recover with exceptional results Realistic aims this season would be to achieve a top 10 or mid-table at the least and given their start, this seems very realistic.
But if everything falls into place, the dream of European football may come sooner than expected.
What are the key strengths and weaknesses of this Wolves side?
Wolves are a well-organised and each player knows their role well.
This is something drilled into them by Nuno who favours a 3-4-3 formation. That organisation enables Wolves to play with their fluid style of attacking football.
But that also allows them to stay defensively strong with Wolves only conceding six goals to date.
However, they have lacked clinical finishing in some games. Against Burnley, they had 30 shots but scored only once in a 1-0 win - that could come back to hurt them if they continue to struggle in front of goal.
How will they be viewing this game, given their impressive start to the season and Palace's struggles so far at home this season?
Wolves will be taking nothing for granted. They'll look to counter-attack at every opportunity and will look to continue their excellent defensive record at the back.
What is the predicted line up?
Nuno has chosen the same starting Xl in every game so it is unlikely he will sway away from that line-up.
Predicted line-up (3-4-3): Rui Patricio, Ryan Bennett, Conor Coady (C), Willy Boly, Matt Doherty, Joao Moutinho, Ruben Neves, Jonny Castro Otto, Helder Costa, Raul Jimenez, Diogo Jota
What is your score prediction?
A 1-1 draw.
Keep up to date with the latest news, features and exclusives from football.london via the free football.london app for iPhone and Android.
Available to download from the App Store and Google Play.


text:
Roland TD-50K2
The Roland TD-50K2 V-Drums electronic drum set delivers flagship-grade performance in a scaled-down size, combining Roland's groundbreaking digital snare, ride, and hi-hat pads and the next-generation TD-50X sound module with Prismatic Sound Modeling and PureAcoustic Ambience technologies. The digital pads bring ultra-detailed playability to the three most nuanced pieces in the kit, complete with full-size playing surfaces for maximum drumming comfort. The TD-50X module provides unmatched tone, feel, and response, plus deep editing tools to personalize your sound and pro connectivity to take on any playing situation. The TD-50K2's space-saving footprint features a complement of premium compact pads.
Get more for your money with an exclusive Roland TD-50K2 V-Drums electronic drum set bundle from Kraft Music. These package deals include the accessories you'll need to get the most out of your new electronic kit, all for one low price. If you have any questions, please contact us. Our knowledgeable sales advisors will be happy to assist in choosing the bundle that's right for you!


text:
Author ORCID Identifier
Date of Graduation
Document Type
Dissertation (PhD)
Program Affiliation
Biostatistics, Bioinformatics and Systems Biology
Degree Name
Doctor of Philosophy (PhD)
Advisor/Committee Chair
Giulio F. Draetta, M.D. Ph.D.
Committee Member
P. Andrew Futreal, Ph.D.
Committee Member
William F. Symmans, M.D.
Committee Member
Paul Scheet, Ph.D.
Committee Member
Helen Piwnica-Worms, Ph.D.
Committee Member
Traver Hart, Ph.D.
Committee Member
Stacy Moulder, M.D.
Tumors are highly heterogeneous and dynamic, continually adapting and evolving in response to their microenvironment as well as external perturbations. Multi-region (spatial) and single cell sequencing has enabled us to anatomize the heterogeneity further and provide evidence of its association with chemo and drug resistance. To investigate this further we took two different approaches to understand the chemo-resistance, and functional heterogeneity in Triple negative breast cancer (TNBC) and Pancreatic ductal carcinoma in situ (PDAC) from an evolutionary perspective.
The first approach was to leverage tumor profiling from an ongoing randomized clinical trial in triple-negative breast cancer (ARTEMIS) to assess mechanisms of chemo-resistance, and use longitudinally tracked patient biopsies to interrogate patterns of response and evolution under chemotherapy. We performed comprehensive molecular profiling using pre-treatment core needle biopsies from 300 TNBC patients treated neoadjuvantly to understand features associated with disease response. We identified six transcriptomic subtypes (ART-Types), each characterized by unique molecular and clinical features. Immune enriched and high proliferation subtypes had higher pCR rates while the low-immune subtype had the lowest pCR rate. Low pCR rates were associated with low T cells, B cells, myeloid cells, high neutrophils, EGFR amplification, and CDKN2A deletions. A machine-learning model integrating immune, transcriptomic and genomic features accurately predict pCR, with validation in a blinded cohort.
By tracking these tumors pre and post-chemotherapy (N=131), using RNASeq and whole-exome sequencing, we interrogated switching of ART-types, changes in transcriptomic phenotypes, and genomic evolution. Androgen response subtype was the most stable, not impacted by chemotherapy, while high proliferating subtypes switched the most. Switch to a low-IM subtype was associated with a poor prognosis. Orthogonally, an increase in immune infiltration and a decrease in tumor purity were associated with higher pCR rates. Similarly, low baseline purity and high tumor ploidy were also associated with lower pCR rates.
As part of a second strategy, we have developed a novel platform using single-cell lineage tracking (clonal replica tumors - CRTs), which enabled us to model and dissect functional heterogeneity in early passage PDAC patient-derived xenografts (PDX) models. These models were used to identify the fitness landscape of individual tumor lineages under three different drugs. High-throughput isolation and profiling of resistant and sensitive lineages were used to establish, and profile them using RNASeq and whole-exome sequencing. The transcriptomic signature developed by probing functional heterogeneity to inform on response to chemotherapy, within the PDX model was able to dissect TCGA pancreatic cancer cohort into groups with significantly different survival.
Computational Biology, Machine Learning, Breast Cancer, TNBC, Cancer Genomics
Included in
Bioinformatics Commons, Computational Biology Commons, Genomics Commons, Integrative Biology Commons, Oncology Commons


text:
Otherwise drummer Corky Gainsford stated that he will part ways with the band in a video he posted on his Facebook page.
Gainsford cited creative differences and personality conflicts as some of the reasons for stepping down from the band after five years. Gainsford's last show with Otherwise will be Dec. 26 in the band's hometown of Las Vegas at the Hard Rock Hotel.
Guitarist Andrew Pugh will also depart and wrap up with the band on Dec. 26.
Some excerpts from Gainsford's video has been transcribed below:
Whats up everyone? This is Corky Gainsford here. There's no real easy way to say this so I'm just gonna come out and say it. After five years in Otherwise, it is time for me to move on to the next opportunity in my music career. I don't know what that next adventure might be; I just know that this is no longer the right place for me anymore. Simply put, artistic differences and personality conflicts in the band have prevented us from being productive creatively, and for the betterment of everybody involved, it's simply time for us to go our separate ways.
My time in Otherwise has been such a great, crazy whirlwind of an experience. I've had so many roles with the band — everything from drummer to songwriter, producer, engineer, tour manager, business manager, merch manager, fix the broken RV or find us a van to get to the next gig on time manager and I'm sure a few other things I've forgotten, but really it's been a great and truly rewarding experience to live out a dream that I worked my entire life towards. So thank you to everyone who has supported us along the way.
I'm gonna continue making music. I will be always making music. It is something that is in my blood, in my bones, in my DNA, and I will never stop making music.
Gainsford also stated in the video that he plans to still show his other artistic side as he will continue to create art on drumheads and cymbals and any other canvas that presents itself. Gainsford went on to say the popularity of his artwork is a blessing and that it's an outlet that he loves to show that creative side of him.
Gainsford closed out the video by thanking everyone who supported him throughout his career. Gainsford also wished Otherwise nothing but the best moving forward while they work on their third album.
Gainford's and Pugh's departure makes the Patrick brothers (Adrian and Ryan) the only two remaining original members left in the band. About a year ago, bassist Vassilios Metropoulos left the band and was replaced by Tony "The Beast" Carboney.
BAND ANNOUNCEMENT:"After 5 years with OTHERWISE, it's time for me to pursue other opportunities in my music career."Please see the video for all the details.Thank you, Corky G*
Posted by Corky Gainsford on Friday, December 11, 2015


text:
A courier who transported thousands of pounds worth of drugs to North Devon for a County Lines gang has been jailed.
Edwin Chance was making his third delivery trip in a week when he was intercepted on the North Devon Link Road when he was intercepted by police.
He was working for an East London gang called Gus which preyed on a vulnerable addict in Barnstaple and took over to 'cuckoo' his home.
They forced Stephen Howells, his wife and two children to live in their bedrooms while they occupied the kitchen and living room.
They forced him to run drugs for them and threatened to harm him and his family when he tried to back out. He has now moved from Barnstaple to Okehampton to get away from them.
He was arrested near his home in Rock Avenue and told police:"I'm working for a gang. They are making me do this. They have threatened my family."
The leaders of the gang are due to be sentenced in London later, but Chance and Howells appeared together at Exeter Crown Court.
Chance, aged 59, of Barrington Street, Tiverton, admitted possession of heroin and cocaine with intent to supply and was jailed for two years and six months by Judge Peter Johnson.
Howells, aged 42, formerly of Rock Avenue, Barnstaple, but now living in Okehampton, was jailed for two years, suspended for two years, and ordered to go on a 19-day thinking skills course and do ten days of rehabilitation activities.
The judge told Howells:"To use the expression, you were cuckooed by the group, who showed their arrogance by taking the kitchen and living room while leaving you and your family to live in the bedrooms.
"I am satisfied that you tried to get away from them and received implicit threats of violence, if you stopped dealing."
Miss Rachel Drake, prosecuting, said the County Line gang used the trade name of Gus and recruited both men.
Howells was arrested on May 4, 2017 walking from his home to Newport Road, Barnstaple, with 13 wraps of cocaine. A further 37 wraps were and £30 were found in a Tupperware box in his kitchen.
Another 91 wraps proved to contain paracetamol and caffeine and may have been intended to be sold as drugs, prompting the judge to joke 'that's a matter for trading standards'.
The total value of the genuine drugs was £500 and there was also a tick list of customers who owed money.
Chance was arrested as a passenger in a Suzuki Vitara stopped on the A361 on September 16, 2017. He had 50 wraps of heroin and 140 of cocaine with a total street value of £2,000.
His two phones showed 252 calls or texts with the gang leader and he admitted making three trips in the space of a week.
Mr Jason Beal, for Howells said he had been bullied into taking part and paid in drugs for his own use.
He said:"It is clear from the wealth of text messages that he took an obsequious and subservient tone and was engaged by coercion and intimidation."
At one point he tried to back out and threw away the drugs he was supposed to sell. In one of his texts he told the gang leader 'Me and my wife have decided we don't want to do this any more. We don't want to lose the kids'.
The reply said that he owed the gang money, would have to carry on, and said 'you're lucky other things don't happen to you'.
Miss Rachel Smith, for Chance, said he was homeless when he got involved with the gang but has sorted out his life in the two years since his arrest and got off drugs.


text:
Store Availability
Enter your Zip Code to view store availability options
Step into the adidas Originals Falcon for a bold, new spin on '90s running style. Mesh and suede form an upper that shows off retro flair, while bright TPU pieces and metallic details complete the eye-catching look.
Product Details
- Mesh lining provides breathable comfort.
- Lightweight EVA midsole cushions your foot all day long.
- Rubber outsole gives you traction, grip, and long-lasting style.
Color Shown: PINK
Style: #CG6211
Shipping and Returns
Orders may take up to 48 business hours to ship. Once the order is shipped you will be emailed a tracking number. If you notice the tracking status reads "Label Created", that means the shipment has been paid for and it's awaiting the first "in-transit" scan by the carrier. Occasionally, shipping statuses can remain in the "Label Created" stage for 1-2 business days.
DTLR wants you to be fully satisfied with your purchase. You can view our Returns Policy here.


text:
God has made good use of Mission Ekklesia in the past year. The founder of the movement is Timóteo Bila, one of our congregation's four leaders. Readers from long ago will remember that he was raised in a Pentecostal church, saved and radically transformed in an Assembly of God congregation while in high school, then discovered the doctrines of grace on the Internet while doing research in college. He was appalled and alarmed at his first exposure to ideas so contrary to what he had long been taught in his charismatic congregations, then impressed, and finally enraptured as God unveiled to him the full-orbed beauty of the gospel of salvation by grace through faith.
In 2012 Bila migrated to Nampula from the capital 1300 miles to the south, expecting that north Mozambique held more promise for employment and ministry. He had attended the Fiel Conference one year before, making the arduous 2600 mile round trip by bus over difficult roads. On that visit he was impressed with the progress the conference and literature ministries seemed to be making with scores of denominations in the north. In the south he had arranged seminars and written books and taught in his own Bible school, but he said the Christians around the capital in the advanced southern section of the nation thought they knew everything already and were hard to reach with the Scriptures! At our conference in the north he saw amongst our humble, untrained church leaders a hunger to grow in their knowledge of God and the Bible.
Yet for all this, his Christianity was anything but pedantic. It had all the warmth and fervor of his Pentecostal origins. A year ago, due to allegations of misconduct (disproved months later), four girls were turned out of a Christian orphanage we have long supported. Julie and I debated on the best way to help these girls and were prepared to accept two of them into our home. But which two? One seemed to be sullen and we feared promiscuous. We could not risk bringing harm to the ministry. While Julie and I debated within ourselves, Bila and his wife Sara, though living on much more limited means, immediately welcomed two of the girls into their home and hearts – one of them being the assumed trouble-maker. When I asked Bila how he and Sara made their choice he said they simply picked the two most needy ones. I fretted about the problems the one adolescent might bring to their family. He simply said, "She is a human being too and needs to be loved." Not surprisingly, she has blossomed under the Bilas' tender care and wise mentorship, and has never caused a problem.
Bila soon got the reading clubs organized that I have featured in previous reports. Our bookstore provides the books free of charge and he makes sure they are read by the men who receive them. He has readers who have been analyzing and debating a book a month for four years now, and they are the classics from Augustine to Luther and Calvin to John Owen to Ryle and Spurgeon, then Pink, Lloyd-Jones, and finally contemporary writers like J.I. Packer, D.A. Carson, John MacArthur, Sproul, Piper, and Paul Washer. These Mozambican men, some of whose ancestors until one generation ago lived almost like cavemen in mud huts wearing bark clothing and consulting witch doctors, have studied under every one of these gifted Bible scholars thanks to Bila's influence in their lives.
From the very first, Bila teamed up with Ibrahimo Hâmido, a Baptist English professor who has been an ardent reader of Calvinistic Christian literature since discovering salvation by grace through faith in the systematic theology course of 2012. Until Valoi of Methodist origins joined them in 2015, Bila and Ibrahimo were the heart of the Ekklesia operation. Another good man, André Kizito from the Assemblies of God, has been an important part of the team. Kizito came to the doctrines of grace in the theology course of 2010. Like Bila, Ibrahimo, and Valoi, he vigorously opposed them at first, but halfway through the course he had to acknowledge their place in the Bible, and by the end was forever transformed in his love for the sovereignty of God in salvation.
These servants of God team up to prepare articles for the Mozambican Christian periodical "Meditai!" (Meditate!) a quality journal written by them in Nampula, laid out for free by a Reformed Baptist graphic design artist in Spain, printed in South Africa, and distributed by Grace Missions in Mozambique. Until HeartCry came on board with funds to help boost circulation, the journal was financed using our family's limited resources. Their last issue was 50 pages devoted to the Supremacy and Sufficiency of Christ, a collection of expositions by them from the book of Colossians adapted from a seminar they had taught to 80 church leaders meeting in the Grace Mission hospital building. Interspersed with their writings were articles from Paul Washer, David Platt, and John Piper.
Their association with HeartCry began when I contacted Paul Washer about speaking at our Fiel Conference. His organization said they generally allowed Paul to take overseas conferences only in places where HeartCry already supported indigenous Reformation ministries. I knew they would appreciate Mission Ekklesia and got them interested. Their Africa regional supervisor, Sean Reece, came to the 2016 Fiel conference and fell in love with the four Ekklesia men. Together with Grace Missions they sent three Ekklesians to get to know the Reformed Baptist work in Zambia, and then paid all the expenses for Ibrahimo to attend a ten-day intensive seminar on church ministry led by 9 Marks in Washington, D.C. Paul Washer even signed on to preach at the 2018 Fiel Conference mainly so he could personally know and encourage these men in their labors, though that trip is on hold while he recovers from a heart attack last year.
Last July Heber Campos, a professor from the Andrew Jumper school of theology in Brazil, was our main speaker at the 18th Fiel Conference in Nampula. Like HeartCry, he too was impressed with the work of these men and soon arranged full scholarships for Bila, Ibrahimo, and Valoi at his institution, provided they could pass the entrance exams, which they all did. Kizito had preached powerfully at the previous three conferences, but this year could not attend, and so missed out on this opportunity.
Now Karl Peterson, my partner in the Mozambique Fiel ministry, and I are seeking to supply the $3000–$4500 each man will need to make several week-long journeys to Brazil each year. The rest of their studies they will do from Nampula while carrying on with their ministry to the Mozambican church.
Besides the journal Meditai!, Mission Ekklesia has offered many intensive weekend seminars on the books of Romans, Ephesians, Galatians, and Colossians, as well as the five Solas of the Reformation and ten rules for correct Bible interpretation. They also teach frequent seminars on Biblical marriage and on Biblical work ethic—two areas noticeably weak in African culture, even in the churches, though the marriages and prodigious productivity of the Ekklesia men themselves is exemplary.
Needless to say I count it an enormous privilege to be so intimately associated with the work carried on by these leaders, all but one of whom got his introduction to Reformed theology in my course. There is no doubt that the explanation for their impressive spiritual output lies with the Lord, but I am thrilled that God keeps sending to me these chosen instruments of His for their first lessons in salvation by grace through faith.


text:
OAKHILL LIONS 1 SOUTH MANCHESTER SPORTS CLUB 2nd 2
South Manchester picked up their first win of the season against a rusty Oakhill Lions.
Oakhill, who have only had two training sessions this season, looked out of sorts and South Manchester capitalised.
Goals from Neil Collins and Michael Hurz were enough to seal the victory.
Oakhill scored one - an excellent finish from Saul Hoyland, but manager Josh Josh Daniels says that was the only positive he could take from the game.
"I genuinely thought we were the better team," Daniels told JC Sport. "South played well, but we should have taken something from the game.
"Our lack of fitness showed; we created good chances but were hit on the counter attack. Their two goals were both from set pieces which just shows how we haven't quite gelled yet."
Oakhill have signed Arthur Caplin from Hendon A and he produced a fine display in goal, as well as Charles Braunstein in the centre of defence.
Daniels went on to say: "Arthur Caplin showed his quality and we are really happy to have him on board. Charles Branstein is another new signing and looked really astute in defence."
Oakhill are still looking to finish the season top of the table and Daniels believes his side can. "I certainly think we can do well. We have quality in the team and I believe we will show that this season.
"All teams seem to be fairly similar in level so there is no reason why we cant challenge right up there."
Written by Ben Lederman


text:
As a valued customer, we truly appreciate your feedback to help improve the Alcumus solutions your organization uses to create a safer, healthier, and more responsible business.
On Wednesday, December 8, the Alcumus CS and Product teams held a webinar to share some of the new features and capabilities we've released in each product and how you can use them. Please see below for the recording. In this webinar, you'll learn:
- Latest eCompliance features and capabilities
- Field iD new features
- New Safety Intelligence dashboards for eCompliance
- Quick "how-to" demos explaining the new capabilities


text:
The installation of advanced production line test technology is helping a world-leading manufacturer of range cookers to uphold its global brand values for high performance top quality products.
AGA Rangemaster made the world's first range cooker in 1830 and continues to be the most prestigious and trusted name in kitchen appliances. With the introduction of new product innovations and technical advances, the company has recently introduced new bespoke and integrated 'end of line' electrical test bays at its Telford manufacturing site.
Utilising specialist Seaward HAL 104 multifunction electrical safety testers and comprehensive Safety e-Base software, the new test approach combines ease of use for operators with the versatility to meet the technical test needs of over 30 different AGA and Rayburn cooker types.
All cooker products manufactured at the Telford factory must undergo a combination of electrical safety and functional tests before being approved for despatch to customers. As well as electrical cookers, the range includes gas and oil powered products, each with their own specific features and often complex test needs.
Products ready for testing are moved into the test cells with failsafe interlocks to ensure the safety of the test operative. Once located in the cage, a bar code scanner identifies the serial number and type of product under test so that the required test sequence is automatically identified.
Following on screen instructions throughout, the operator activates the testing and the HAL 104 automatically runs through multiple test sequences according to the type and specification of the cooker. Earth bond tests are carried out on all appliance touch points, followed by hipot and power/leakage tests.
For high power products, the test range and capabilities of the HAL is extended by the use of a specialist Powersmart unit.
Any failures at any stage in the test process cause the process to be automatically aborted, enabling the specific fault to be identified and rectified before the product is re-tested. Only those products that successfully pass all testing then go on to an inspection and photography stage, before being packed for shipment.
All testing of products in the AGA and Rayburn cooker ranges is undertaken to confirm product compliance with EN60335 and the specific test data is stored against individual serial numbers to provide a comprehensive product record in the company's database.
In developing the new integrated and bespoke test process, Seaward's technical support team worked closely with AGA Rangemaster production engineers to ensure that the new system met all the company's needs.
William Fletcher, AGA Rangemaster production engineer, said: "The new approach takes our test capabilities to the next level and not only ensures the electrical safety of all of our products, but also helps us to maintain rigorous product performance and quality control standards.
"The combination of automatic sequencing of testing and step by step on screen instructions has reduced the technical training required by operatives. In addition, when any subsequent product issues have arisen, the database availability of automatically recorded test data results has assisted in satisfying any warranty issues".
"Throughout the installation and commissioning of the new test stations, Seaward's technical guidance, hands on support and troubleshooting has been invaluable in ensuring that we have a system that completely meets our needs and is making a significant contribution to the efficiency and success of the business."
Safety testing specialist Seaward is a longstanding supplier of electrical test equipment to AGA Rangemaster and also has systems installed at the company's Leamington Spa factory.
Lee Warburton, Key Account Manager for Seaward Compliance and Precision Products, said: "The new system combines operator safety, with simplicity of use and total versatility across the AGA and Rayburn product range.
"The safe operation and quality of performance of electrical products is absolutely vital in terms of product conformance and quality assurance, so we are delighted to have worked with such a prestigious company in developing a system that successfully meets their specific needs."
Find out more about Seaward's range of manufacturing and production line hipot testers at seaward.com/manufacturing.


text:
This article is written by Dave Hill
As usual we were years behind the Europeans, they had been allowed picture postcards (PPC's) years before the UK. Our PO could not understand that anyone would want to write a message that the postman (amongst others!) could read! Yet in a few years our PO was handling many millions PPC's a year! Many of our PPC's were printed on the continent so it must have been difficult to print PPC's one size for themselves and another (smaller) size for the UK.
Between 1895 and 1899 court size PPC's were allowed 4.75" x 3.5" usually the picture was a vignette with space below for a short message, only the address was allowed on the other side, these are called undivided backs. Illustrated is an unused court size postcard with a vignette of the Law Courts, London, note the "squarish" size and undivided back.
In 1899 standard size PPC's were allowed 5.5" x 3.5" to bring us into line with the continent, often there was a space below the picture for a short message or the writer wrote around or over the picture! Only the address was allowed on the other side. Illustrated is a 1901 used card of the Embankment, London, still with an undivided back.
Finally in 1902 divided back PPC's were allowed with message and the address on the same side, the picture could occupy the whole of the other side.
The public soon realised the utility of the PPC, before the telephone and with as many as 6 deliveries a day in London, it became a way of sending messages like "see you at 2 PM this afternoon", all for ½d! The ½d rate for postcards, 1d for letters, lasted till WWI, 74 years, hard to imagine when soon it will cost £1 to send a letter!
Shown is a 1904 used postcard of Southport, a divided back card but stamped "Contrary to Regulations" and charged 1d postage due, it is only an 1/8th of an inch too wide!
So to summarise for anyone listing British PPC's:
Until 1899 court size 4.75" x 3.5", undivided back
Until 1902 5.5" x 3.5", still undivided back
Then 5.5" x 3.5" but divided back


text:
Cryorig H5 Universal: Unboxing
This is just a simple unboxing of the Cryorig H5 Universal CPU cooler with a picture log of contents and first impressions. With a lot of Intel i5 and i7 users out there, we thought this cooler would be a great candidate for an overclocked Intel i7-6700k series desktop processor. At stock voltages and clock frequency, the Intel i7-6700k has a TDP expectation of 91-93W in total and should make for a great test case.
Given the 91-93W TDP needs of our Intel i7, the Cryorig H5 Universal is specified as providing a 160W max thermal dissipation. With that knowledge, we will push our Intel i7-6700k to it's thermal limits and see what kind of results we could get. The results of this will be provided in the final review, but for now enjoy the unboxing and preview of this unique cooler.
First Impressions
The box is rather standard with a white and gray theme which matches the crisp and lite design of the cooler itself. The box clearly states 160W TDP (on the back) and provided a simple but visually appealing preview of the cooler inside.
Opening the package, it's tucked in neatly and protected by brown cardboard and heavy lined plastic. It comes with the fans and shroud pre-installed and only requires the base/mount installation. Based on the packaging and online material (prior to purchase), it supports the following sockets:
Intel Socket | AMD Socket |
What does this mean? Welp, it pretty much means that if you have an AMD or Intel desktop processor within the last 11 years, this cooler will fit your socket/cpu. A lot of the popular coolers currently on the market don't ship with AM4 mounting equipment but this unit does. There is a list of AM4 compatible Cryorig coolers and if brackets are included or should be requested here.
Visually, the fins have a unique hex/hive style bending and provides a different look and style to your normal heat fins on most coolers. It's advertised as providing enhanced cooling through increased surface area and space. This might just be marketing but it has some merit and will need some testing to check this coolers overall viability.
The CPU cooler feels very solid and has a total of 38 fins and 4x6mm heatpipes to dissipate heat. The base is listed as C1100 pure copper nickel plated and the fins are straight aluminum. Total dimensions of the heatsink are L98mm x W143mm x h260mm (for those measuring case clearance). The cooler is decent in size but compact enough to provide clearance for all RAM slots. I provided a few photos next to a standard 3.5" HDD for scale and reference. Based on material from Cryorig, it's been measured to provide cooling up to 160W TDP at a max of 24 dB(A)!
Final Thoughts
Overall, this unit seems to have excellent build quality and visual design. I have yet to test the cooler but it looks and feels promising. The specs on Cryorig's website are impressive for it's size and MSRP pricing. I will update this post with a link to the final review and results of putting this cooler to the test. Thanks for reading and I hope you enjoyed the this Unboxing!


text:
We know that our dogs are social creatures, this means that when dogs get together, they must have ways of relating to each other without conflict. It is obvious that your dog doesn't talk to other dogs in our language. They must have their own way of understanding each other.
You see dogs in the olden days survived by banding together, they hunted, fed, defended their territory, and led a communal life together. If you have ever lived a communal life, you will know how easy it is to get into a conflict even for the most immaterial things, but dogs then found a way to overcome this problem. My theory is that they did this because their very survival depended on it.
So dogs do not only communicate well with each other, they understand themselves perfectly. They have ways of identifying each other, resolving conflicts, and even reducing tension when it builds up. Truth is, when you get to understand how your dog communicates, it makes it easier for you to handle them.
Can dogs talk to each other without barking? Yes, If you have ever observed dogs meeting each other for the first time, there is this kind of dance that they do, they circle each other and sniff out areas which we as humans would not do with each other. What you are witnessing even though strange is a gentleman or lady-like interaction between the two.
It is the equivalent of you shaking a man or woman's hand and saying hello my name is(insert your name here). What is your name?
To explain more, while we are heavily dependent on our senses of sight, touch, and voice to communicate, our dogs are heavily dependent on their sense of smell, taste, and sight for communication. Of all these senses of smell, the one our dogs use mostly is the sense of smell.
Within a dog's nasal cavity, they have an organ called the Jacobson's organ. This organ allows our dogs to analyze the sense of smell on a level we cannot fathom, they are able to determine the sex, age, health status, places the dog has been to, and more just by sniffing on the dog.
Our dogs love smells that are strong in their natural scent and the places heavy with these kinds of smell are the genitals and anus of the dog, hence their preferred areas to sniff on and get proper information on their new friend.
After getting to know each other, the next level of communication is through body signals. Our dogs can communicate in many ways just by the way they position their tail, move their heads, position their ears, etc.
For example, a dog moving their ear forward means he or she is interested in what is in front of him. A stiff tale may mean the dog is alert to something, lowered head, averting eye gazes, signs of submission, clenched teeth, tucked-in tails, and more.
We would go into more details of the meanings of each of these expressions later but for now, you need to understand that body signals are one of the ways our dogs communicate.
Barking is another way in which our dogs communicate with each other. While communicating with barking, the intensity and tone are important. You have to take into consideration how they are barking, which dog they are barking at, the time they are barking at the dog, the activity they were involved in. All these combine to make this communication path meaningful to our dogs.
Dogs can also communicate by howling, grunting, and yapping at each other.
As with all communication, there must be at least two parties involved. The same here with dogs, you will notice one dog initiating the communication by their normal greeting using their sense of smell, then there is this reciprocal use of body signals and movements to keep the communication ongoing.
A friendly communication would look like a give and take meeting with the dogs taking turns to express each other, with them smelling and sometimes licking each other, this gives way to various body signals from the dogs and then a bark here and there usually when play has been initiated between them.
Communication that is confrontational would be violent, with the dogs looking as if there is a face-off, unlike in playful confrontation where the dogs pin themselves and allow the other to get up. Confrontations that are violent would have a dog pinning another dog and holding them down, this could be by biting them or using their full weight to hold the dog down depending on their size.
If you notice an interaction where one dog is doing the sniffing and moving about and barking with the other dog being in a submissive position, you are likely witnessing a dog bullying another dog. This is not a good thing and if it is in your power get the dogs separated.
Let's go into some specific details about the meanings of our dog actions and what they are communicating.
Eye signals.
Dog blinking eye means they feel the situation is tense and are trying to defuse it.
Dog avoiding eye contact is a sign of submission and sometimes used as a calming signal.
A dog making direct eye contact is a dog showing dominance, a warning of an impending attack or threat.
Ear signals.
Ear flickering forward and backward is a sign of indecision, it can also be fear.
Ear standing erect shows the dog is alert or paying close attention to something
Ears flat on the head with teeth bared is a sign that the dog is anxious.
Body Signals
Lowered body posture while looking up indicates submission.
Hair standing on the back indicates uncertainty, fear, and possible aggression.
Upright posture with stiff legs shows the dog is in a dominant position.
Dog sitting, when approached by another dog, indicates acceptance, not submissiveness.
Dog rolling on back and closes eyes is a strong sign of submission.
Dog rolling on back and rubbing shoulder on the floor is a sign of being content.
Tail Signals
Tail held high indicates that the dog is confident and is currently open to being approached by other dogs and even humans
Tail held backward but not stiff indicates your dog is concentrating or attentive to something.
Tail held backward and in a stiff stance shows readiness for a challenge, if threatened in this position, the dog can get aggressive.
Tail lowered and swishing around shows a relaxed dog, free of worry at the moment.
Tail tucked into hindlegs is a sign of timidity and in some cases fear.
Tail wagging very fast indicates that your dog is very excited at the moment.
Slight tail waging means your dog is greeting, it may be you or another dog
Broadtail wagging with hips moving from side to side shows the dog is happy and greeting you at the same time
Fast tail wagging means your dog is very excited.
Rapid barking continuously, your dog's way of raising an alarm call for you.
Backing and pausing, your dog senses a threat but not too sure what it is.
One or two short bark, usually a greeting bark.
A single short bark, usually means your dog was startled or surprised.
Howling Signals
A yip howl is used when the dog is lonely and wants some companion
A normal howl is a dogs way of saying I am in my territory
A baying howl is used to call pack members, it is also used in tracking them
A bark howl is used to indicate that the dog is in isolation and needs company, normally, this type of bark is done in twos or threes.
Growling Signals
low pitch growl coming from the chest is a warning threat
A soft growl means stay away from me
A Noisy growl with teeth hidden is expressed when the dog is intensely concentrating on something.
Whining, yelping, and whimpering
Soft whining and whimpering show that the dog is hurt or scared of something.
A single yelp or a loud high-pitched bark is an involuntary response to sudden pain.
Continuous yelping shows the dog is in pain or extremely afraid of something.
Get more in-depth information on dog communication by clicking here
Dog communication is more in-depth than what we have addressed above, but what we have stated would put you on the right path to understanding why our dogs do what they do. This will help you bond better with your dog and have a relationship that will be the envy of people around you.
Hi, I am Charles Nwankwo Editor-in-Chief, Mydoggything.com. Gleaning from Professional Dog Trainers, behaviorist, Registered Veterinarians, and Breeders. We are passionate about making dog care easy for you. My job is to make sure that you get the best-updated dog care information to understand and take care of your dog or dogs.


text:
[su_heading]Stanley Enow,Nabil Fongod[/su_heading]
Stanley Enow joins Nabil Fongod and Tenor in the ultimate music meets fashion trio photo shoot. The three kings were on the set of a photo shoot campaign to fight violence and sexual abuse against women. The stars came on set showing off their casual wardrobe and easy summer styles. They all wore white t-shirts paired with different styles of sunglasses. It appears the musical kings are inspiring a major aviator sunglasses comeback for summer 2018 the world over.
Radio host Nabil4Real of Nabstar Radio kept his look fresh in a dark designer sunglasses. The much loved radio star also modeled top by Cameroonian designer Soh Patrick. He finished off his look with Zara jeans and a pair of Gucci sneakers.
See More: Men's Style
Stanley Enow, Nabil Fongod, Tenor
Tell us whose style you're digging the most and why?
Hit refresh on your everyday edit with the boss looks:♥


text:
Meet baby Cameron <3. He and his family came to my studio in Bridgeville, PA. He was so sweet and slept through his whole session! Mom and dad were great at preparing for the session, and big brother was a fantastic listener! I love the one of him kissing his little brother. It is not easy for siblings to stay still for long in general, let alone while holding their newborn sibling, but this guy rocked his pictures!
I always like to plan the session in advance so parents know what to expect for the studio experience, especially for the setups. Cam's mom knew she wanted cool tone colors, with grays, blues and neutrals. These colors were perfect for a baby boy, and she knew the final framed images would compliment their home!
Excited to watch this little family grow!
If you are looking for a Bridgeville newborn photographer or a Pittsburgh newborn photographer, I have a few openings left from now until August 2021. Contact me here so we can plan your session!
More information here!


text:
All the reasons to go on a trip are good: they're yours!
Of course, to go on a trip far and long, you need a strong motivation, especially when you send everything away …
You have to brave the disbelief of your loved ones who love you and who don't want to see you run off to the ends of the earth with a bag on your back. They are worried, sometimes jealous to see you undertake what they are not capable of.
Don't feel alone, I've been there too…
l However, there are some questions that you have and that hinder the realization of your travel project? Perhaps the answers can be found in these lines, dictated by these years spent on the roads of the world.
You have been dreaming of this great departure for a long time, but you always postpone it from year to year, paralyzed by worries, anxieties, etc.
The advice and testimonials of my personal journey will help you to see more clearly and to cross the Perhaps you will also see in it the confirmation that this great journey that you have dreamed so much of must remain a dream and that it is not a project for you?
But whatever the outcome, you must first of all conduct a little introspection, list the reasons that inspire you to make a big change in your life. Sort out the illusions and certainties, the expectations and challenges that await you for sure in this immense adventure that is the long journey!


text: Ivan Bono was born in Piedmont Italy in 1973. He moves from painting to sculpture to music with natural ease. A little more than a child at home of friend and sculptur Urano Palma he meets Mario Schifano, who fascinates him with his aggressive way of painting that will characterize his way of making art. From 2001 he attends the groups of young artists from Germany, France, Denmark and Netherlands, where he refines and matures pictorial and creative experiences. In 2005 he is invited to the exhibition of modern art at Paris, for 2012 Olympic Bid and the following year he moves to London where different works born with the applications of metal grids to symbolize the decadence of modern society. Back to Italy Ivan starts the emotional cycle, where colour is mixed and shaded directly on canvas with a technique developed in previous years. From now on Ivan shows in major exhibitions with great critical acclaim and sales. Since the early graffiti and mural paintings to the wool canvas, prices have seen a relentless rise and contacts started with international museums for exposure and acquisition of Ivan works. Ivan Bono works, citizen of the world, with studio in Rovasenda, tell from the deep about that wild and primeval energy which well represents Ivan spirit: Creating is an instinctive need for me, almost primeval. I have to follow it and make it immediately concrete expressing the emotion, without any delay. Then, when I finish my work, I leave everything as it is. I have no second thoughts. If the day after I dont like my work, I destroy it, and I never modify it, never! So we see the bright reds almost flowing blood, sharp blacks lighted and dazzled by icy sharp blades. Esoteric signs and ancient scriptures are impressed on canvas in order to show universally his own message. So Wild Canvas enough wild to represent his world. Ivan uses to create everything that the world doesnt want anymore, dismisses: wood, iron, cloth and wool, glues, silicones, glasses, tars, enamels. Ivan smells, caresses the material and then he reassembles, mends, stratifies or reduces to shreds. Never quiet, never satisfied, he lets the music, classic or rock, to support its creative act. Not at all drawn in the role of the famous artist, even if the international and Italian critics are creating a prestigious contacts network, Ivan Bono is a simple and easy person, whom having a chat is a great pleasure: It has been a travel to link me forever to art. In 2003, only for learning, I lived in Amsterdam, Hamburg, Copenhagen, Oslo, Stockholm. I was a guest of street artists and social centers, of common people, people from Lofoten islands or Andenes fishermen, I left everywhere a part of me: the first iron sculptures, the enormous graffiti on Kaart Cultural Circle walls in Hamburg and all sizes drawings sold on the street. In Barcelona born a wood lamp Eyelid and the armchair Wacca. In 2006 Ivan is back in London, as Leevan, and his works are in numerous art galleries in East End. In 2007, the golden year, Ivan exposes to Parma, Ferrara, Riccione, Forlì and Padova Modern and Contemporary Art Fairs. He works for CVB Gallery in Newyork and Saatchi Gallery in London, then important museums in Seattle, Luxembourg, etc.. In 2008 Ivan was one of the six artists invited to the Milan International Tourism Exhibition and from that year the mantra of his works took a new direction by making the acronym V.I.T.R.I.O.L. his own. and proposing it in an obsessive way in all areas. The works take a direction abandoning the classic style of painting and sees the use of only poor and exclusively recovered materials among the scraps of the consumer society and here woods, irons, tars, glass and rubble become real forms of art penetrating the hidden meanders of our souls, perturbing and permanently upsetting them. The following years saw him participate in various exhibitions organized by galleries throughout the national and international territory such as Modern and Contemporary Art fairs and his works were acquired by the Meeting Art Auction House. In 2011 Ivan received new national and international confirmations thanks to the acquisition by the Museum of Modern Art of Palermo of the work "Der Suchende" and the awarding of the work "Yellow Net" during the Tokyo International Award at the Hotel Four Seasons in Tokyo. In summer 2011 a new sculptural installation, Ivan donates his art to Neptune, placing an iron and rock statue 15 meters deep at the Byron Cave of Portovenere (La Spezia - Cinque Terre) and in 2016 one of his sculptures is chosen to create the Apneaworld trophies to reward the athletes who have distinguished themselves in the world championships in indoor apnea. And the adventure continues .. Previous Exhibitions: Turin, Milan, Newyork, London, Paris, Hamburg, Copenhagen, Barcelona, Berlin, Ferrara, Forlì, Parma, Genoa, Tokyo, Perugia, Rome, Palermo, Vercelli, Alba, Parma, Riccione, Padova, Washington Permanent works present in: Biennale Lecce, Seattle Fine Art Museum, Museo di Arte Modena e Contemporanea Sciortino di Palemo, CVB Gallery New York, Fondazione Banca Sella, Palazzo Ducale di Revene (Mantova), Saatchi Gallery London, Galleria Via dei mercati Vercelli, Alba Gallery, Galleria la Telaccia, Artetivu


text:
British Prime Minister David Cameron bought his wife Samantha a car at the weekend, paying just £1,495 for a Nissan Micra from a second-hand dealership, according to a news report.
Iain Harris, owner of Witney Used Car Centre in Cameron's Oxfordshire constituency, told the Independent he thought it was a joke when he got a call saying the prime minister wanted to look at a car. But when Cameron turned up he thought: "Oh my God, it is Mr. Cameron and he is here and it's not a wind-up."
Harris said he believed Cameron was buying the car for his wife. "He looked it over just like any bloke off the street, but not someone with mechanical knowledge," he said. "I didn't give him a discount."
The car dealership boss said he had joked that the color of the car — blue, the color of the Conservative Party — was right for Cameron, but that was as political as the conversation got.


text:
Currently, in ABB office in Warsaw we are strengthening our Auditing Team and therefore we are looking for a candidate who is interested in position:
Senior Internal Auditor
Job Reference Code:
As a Senior Internal Auditor your main objective will be to participate in the execution of regular operational and financial audits and implementation of the internal audit mission which is to provide independent and objective assurance and consulting services designed to improve the organization's operations.
The mission of the internal auditing function is to provide independent, objective assurance and consulting services designed to add value and improve the organization's operations. It helps the organization accomplish its objectives by bringing a systematic, disciplined approach to evaluate and improve the effectiveness of risk management, control, and governance processes.
- Participate in and / or lead the execution of complex operational and financial audits (pre-, on-site and post phases) for different business processes;
- Collect, analyze, interpret document/information to arrive at audit result, and prepare work papers in accordance with ABB Audit procedures/standards;
- Accurate evaluation of the internal control system of the audited unit;
- Document audit findings, risks and recommendations and prepare audit report;
- Prepare and/or perform quality review of audit work papers i.e. sufficiently complete, detailed and accurate to ascertain the audit work done and to support conclusions reached;
- Responsible for the preparation of audit reports summarizing findings, risks and recommendations;
- Responsible for the communication of audit results to audited management;
- Communicate results to Auditor in Charge/Internal Audit Manager and/or Audited Management;
- Identify other risks within the audited unit besides the audit scope performed;
- Assist in compliance audits (pre-, on-site and post phase) and prepare audit work papers;
- Communicate findings with the Audit Manager and/or Regional Head of Internal Audit.
- 4-5 years in Audit, including strong operational experience;
- Degree in business administration / economics or engineering;
- Preferably CIA/CISA/CPA certification;
- Strong analytical and IT skills;
- Willingness to develop leadership skills;
- Ability to operate within teams of different cultures;
- Managerial courage to confront difficult issues with the appropriate response;
- Strong oral and written communication skills, proficiency in English;
- Preferably international business experience,
- Willingness to travel internationally (up to 70%).
We offer:
- An interesting job in a company promoting innovative and modern technologies;
- Opportunity for professional development in an international environment and for increasing your abilities and skills in various areas;
- Employment in a stable company with an established position in the market;
- Attractive salary based on your professional experience and skills;
- Good working environment.
Additional Information:
To apply for the position, please send your application (Curriculum Vitae in English) >> via ABB's page << or using the button under the advert.
We reserve the right to answer only to the chosen candidates.
We kindly ask you to include in the Curriculum Vitae the following passage: "I hereby agree for my personal data, included in my job application, to be processed in line with the needs of recruitment, in accordance with the Law on Personal Data Protection of 29 August 1997 (Law Gazette from 2002, No.101, heading 926, as amended)."
ABB (www.abb.com) is a leader in power and automation technologies that enable utility and industry customers to improve performance while lowering environmental impact. The ABB Group of companies operates in around 100 countries and employs about 140 000 people.


text:
Patent of the Week: Improving Post-CPR Outcomes in Heart Attack Patients
Cardiogenic shock occurs when the heart has been damaged and is unable to pump enough blood. It is a common cause of death, usually brought on by a severe heart attack. It also can occur after a patient receives CPR, though why this happens is not well understood and current treatments that restore heart function do not protect against long term damage.
An associate professor of medicine at the University of Chicago, Willard Sharp combines his clinical practice with an NIH-funded translational research program focused on developing novel therapies.
Through this research he has demonstrated that the main mechanism leading to post-CPR cardiogenic shock is myocardial stunning, which is specifically caused by mitochondrial damage.
To help improve post-CPR outcomes in cardiac arrest patients, Sharp has invented a novel treatment method that involves the administration of novel small molecules that inhibits myocardial stunning.
The patent-pending method addresses a novel mechanism of action for cardiogenic shock, reduces neurological damage, and improves a patient's overall long-term outcome following CPR.
// Read more:
- Small Molecules That Improve Post-Cardiac Arrest Outcomes By Protecting Against Mitochondrial Damage – Polsky Technology Publisher
- Suppression of Superoxide-Hydrogen Peroxide Production at Site IQ of Mitochondrial Complex I Attenuates Myocardial Stunning and Improves Postcardiac Arrest Outcomes – Critical Care Medicine
- Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice – Oncotarget
// Patent of the Week is a weekly column highlighting research and inventions from University of Chicago faculty.


text:
"Readers will reach for [ONCE UPON A WARDROBE] again and again, eager to be reminded that love will prevail and imagination leads people down fantastical paths."
by Patti Callahan Henry, writing as Patti Callahan
Patti Callahan's powerful and captivating new novel ponders how the events in C. S. Lewis' life, particularly his childhood, inspired him to create the magical and mythical world of Narnia and the cast of characters inhabiting it. From "stepping through the wardrobe" to "the white witch" to "Narnia" itself, these terms and concepts are woven into the fabric of American culture and lexicon. But few people probably stop to think about how and why Lewis created this delightful place.
Set in 1950, ONCE UPON A WARDROBE follows 19-year-old Megs Devonshire and her eight-year-old brother, George. Megs studies math and science at Oxford and relies on facts versus intuition; stories have never held much interest for her. When terminally ill and bedridden George becomes infatuated with the newly published THE LION, THE WITCH AND THE WARDROBE and implores her to find out more about the source for Narnia, Megs finds herself visiting C. S. Lewis, an Oxford don who goes by Jack, and his brother, Warnie, in hopes of answering George's questions about the fantastical world.
Instead of providing direct answers, Lewis entertains Megs with stories about his own life growing up, which he asks her to relay to George on her weekend visits home. While Megs grows frustrated and struggles to find the connections between Jack's stories and Narnia, George immediately intuits that Jack's childhood provides the source for his mythical land. As the novel progresses, George helps Megs come to understand the importance of stories and imagination, and the role they play in healing, entertaining and creating community.
Callahan has clearly poured her heart and soul into this book. It is part tribute to Lewis' iconic series and its impact on today's world, and part testimony to the power of literature and stories to bring people together and to impart wisdom in a way that no other medium can.
In a nod to the book's brilliance and Callahan's ability to understand Lewis, the value of stories, and the way that he wove himself and his early life into Narnia, Lewis' stepson, Douglas Gresham, writes a heartfelt two-page letter at the end of the novel about ONCE UPON A WARDROBE and Callahan herself. He states in part, "This is not merely a book worth reading, it is a book that will drive us through the difficulties of love and of sorrow, to struggle, gasping onward and upward, our emotions surging with us, until we are brought, once again, to love." There is no better way to describe what Callahan has accomplished with this novel.
Readers will reach for it again and again, eager to be reminded that love will prevail and imagination leads people down fantastical paths. Some books are read and forgotten soon after; others linger forever in one's mind, popping up from time to time when something relevant sparks the memory. ONCE UPON A WARDROBE is certainly the latter and will be cherished by anyone who reads it.
Reviewed by Cindy Burnett on November 12, 2021
Once Upon a Wardrobe
by Patti Callahan Henry, writing as Patti Callahan
Publication Date: October 19, 2021
Genres: Fiction, Historical Fiction
Hardcover: 320 pages
Publisher: Harper Muse
About the Author
Photo Credit: Bud Johnson Photography
Patti Callahan is a New York Times and USA Today bestselling author of sixteen novels and podcast host. She is the recipient of The Christy Award — A 2019 Winner "Book of the Year"; The Harper Lee Distinguished Writer of the Year for 2020 and the Alabama Library Association Book of the Year for 2019. She is the co-host and co-creator of the popular weekly online Friends and Fiction live web show and podcast. Patti is also a contributor to the weekly life lesson essay column for Parade Magazine. A full-time author and mother of three children, she now resides in both Mountain Brook, Alabama, and Bluffton, South Carolina with her husband.


text:
(This anthology would be based on H. P. Lovecraft stories/creatures that are in the public domain.)
The cults of the elder gods were used to the power and terror they wielded over an unbelieving world. They had immortality, the power to inflict madness, and the ability to command unspeakable terrors to do their bidding.
But for various reasons, the elder gods from the world. One by one, they are vanishing.
Follow this band of cultists / elder god conservationists as they attempt to keep terror alive.


text:
From Thomas Jefferson to Thomas Beale Ewell, 13 November 1823
Monto Nov. 13. 23.
Th: Jefferson returns his thanks to Dr Ewell for the copy of his eloquent oration of the 4th of July last, which he has been so kind as to send him. he recognises in it the true spirit of 76. and rejoices always to see the ardor of those days still fostered in the bosoms of his f. c. and with his thanks he prays Dr. E. to accept the assures of his constant attamts and best wishes for his health & prosperity
DLC: Papers of Thomas Jefferson.


text:
Q & A: Sentia
Sentia are uncompromising in their craft. Spurring a new embrace of prog and synth into a melting pop of emotional tension, Bruisin' is this year's best hate song. Not to mention it's killer video clip. Chatting over email, we found out how Sentia release their pent up frustration and convert that into their music.
The film clip shows some awesome parallels. What was the ultimate message behind the clip?
I guess the message behind the clip is more of a question. What is reality? We really wanted to paint a dystopic picture of a man who is deluded and trapped by his own misconceptions of reality. The idea of perception and what is real really intrigues me. Reality is such a subjective experience and there are always so many different takes you can get on any given situation. It's easy for people to lose perspective and become stuck in their own twisted version of reality. Throw people's beliefs, bias and even mental health into the picture and it can become a pretty complex knot to untangle.
How did you put this clip together? Any crew that deserve shoutouts for putting together this masterpiece?
We hired our good mates, director/producer Jesse O'Brien and cinematographer Samuel Baulch, who have been working together for years and recently completed the sci-fi feature film, 'Arrowhead'. They assembled a crew and footage was shot over two nights. One night in a studio for all of the band footage and a night in an eccentric junkyard/arts space for the story. After that we had a lengthy post production period to get all of the special effects right. Thankfully, our guitarist, Jason, is a crazy talented post production editor and used a heap of his own time, as well as the help of a few of his associates to bring the finished product up to where it landed.
Are you guys fans of the booming synthwave movement? I can hear a small influence on your music.
I think growing up in the '80s and '90s, you can't help but be kissed by the neon of synth music—not to mention the electronic soundtracks from classic sci-fi films. There are a few modern synthwave artists that have made it into my playlists, for sure. There was a period where M83 definitely got a good spin, and some of us are pretty into the likes of PVT, Vangelis, Daft Punk, etc.
Bruisin' is written as a hate song. Is music your way of lashing out and emoting this way?
I absolutely use music as a way to work through whatever I'm going through, to make sense of what it means to me in search of a catharsis. It kind of has a funny duality to it in that the act of putting it down and letting it out is a great way to work through something and move on, but then you have to bring it up time and again when you perform it live.
Do these emotions intensify on stage?
Absolutely!!! I get really swept up in the moment and the emotion of it all when I'm onstage. My favourite artists have always been the ones who you know are truly feeling what they're singing about. I think there's a lot of pretence in the world and as a result, when I see someone being unapologetically honest and real through their art, I think it is incredibly powerful and captivating. I try to give that same experience to people who come to see us play.
Without music, how else do you think you'd be able to vent your emotion in this raw way?
As much as music is special and incredibly powerful in that space, thankfully I have been able to find many other ways to channel my emotions. I find a lot of peace in both physical exertion and stillness. Surfing—to me there is something incredibly magical and healing about the ocean. Meditation—something that I've been working on for several years now and am continually humbled by the scope of how much further the rabbit hole goes. Exercise, laughter, sex, therapy, tears, hugs, friendship, conversation, thought, reading, learning, family. Just to name a few.


text:
- firstname.lastname@example.com
- (858) 534-3697
- (858) 534-1080
9500 Gilman Dr
Mail Code: 0344
La Jolla , California 92093
Todd Salovey
Continuing Lecturer in Acting
- Biography
- Education
- Office
Todd Salovey teaches acting in the undergraduate theatre program, as well as teaching Introduction to Theatre, graduate directing, and supervising many graduate student instructors. He is in his 25rd season as the San Diego REP's Associate Artistic Director.
Mr. Salovey directed the original workshop production of Herbert Siguenza's A Weekend with Pablo Picasso at San Diego REP and its world premiere at the Alley Theatre in Houston. He also directed subsequent productions at Los Angeles Theatre Center, Center Arts Rep, and at Denver Center Theatre Company. Mr. Salovey has directed many acclaimed REP shows including A Hammer, A Bell and A Song to Sing, which he also authored, and The Blessing of a Broken Heart for which he won an Edgerton New American Play award, the English language premiere of In the Time of the Butterflies, King Lear, Hamlet starring Jefferson Mays, The Road to Mecca, Doubt, Brooklyn Boy, the world premiere of Yehuda Hyman's The Mad Dancers, Uncle Vanya, and Death of a Salesman starring Michael Genovese, Edward Albee's Who's Afraid of Virginia Woolf?, The Illusion, The Dybbuk, The Imaginary Invalid, Three Hotels, and A Christmas Carol.
At UCSD, he has directed Six Characters in Search of an Author and Stage Door. As the Founding Artistic Director of the Lipinsky Family San Diego Jewish Arts Festival, he has commissioned and developed numerous new pieces of music, theatre, and dance that have been premiered in San Diego and gone on to be performed throughout the world. He produces many REP Surround Events, including Talkin' Theatre with Todd. Todd is married to Diane Boomer and is the very proud dad of Leah and Aryeh.
MFA, UC San Diego
Galbraith Hall 133


text:
The founder of Hillsong Church, Brian Houston, has said that he regrets not acting sooner to address the issues arising at Hillsong East Coast, which culminated in pastor Carl Lentz being fired for moral failures.
In an email to members, Houston said that Hillsong East Coast had "failed to reflect global Hillsong culture" and promised to work on changing the church's working environment after several damning reports emerged of staff and volunteers being treated poorly.
"Every Hillsong location must honour our commitment to creating a caring and healthy environment for our team, volunteers and members," Houston explained. "Under the previous pastor, this was not always the case. Serious concerns and incidents must never be ignored. When problems arise, proper and effective reporting mechanisms must be in place. And proper guidelines should be enforced. And when failings occur, especially among senior leaders, they must be addressed."
Houston said that while he wasn't aware of Lentz's affair until late last year, he regrets that he "did not deal with the leadership issue much earlier".
"I chose to trust at times when I should have taken more decisive action. I gave the benefit of the doubt when I shouldn't have," Houston said.
"Our global team is determined to reflect carefully on what we've learned and make any changes necessary, even difficult ones, to guarantee that all our leaders are held to the highest standard."
Houston announced the investigation back in November last year, shortly after firing Lentz for infidelity: "We are launching an independent investigation into the inner workings of Hillsong NYC/ East Coast. We need a solid foundation for a fresh start and new beginning," he tweeted at the time. "The best is yet to come."
Lentz has relocated to California with his family. He has not posted to Instagram since November 5th, when he admitted to having an affair: "I was unfaithful in my marriage, the most important relationship in my life and held accountable for that," he wrote at the time. "This failure is on me, and me alone and I take full responsibility for my actions. I now begin a journey of rebuilding trust with my wife, Laura and my children and taking real time to work on and heal my own life and seek out the help that I need."


text:
Similar to other popular gaming consoles, Nintendo Switch owners can transfer their save data from one console to another. This feature comes in handy for users who have two consoles or for someone who wants to transfer save data to a different Nintendo Switch. In this guide, you will learn the steps on how to transfer data to Nintendo Switch.
Important Things to Check before Transferring Data To Nintendo Switch
Nintendo Switch has become the best selling console of 2020 due its hybrid design and exciting games that are only available for purchase exclusively for their consoles. As the portable gaming device comes with features which are easy to navigate, transferring data between consoles is fast and simple. However, you need to ensure that the following details are checked:
- Both Nintendo Switch consoles should be connected to the same internet.
- If the source console is broken or damaged, transferring data is not possible.
- The Nintendo Switch where to transfer the data must be nearby or close to the other console.
- The system menu version of both consoles should be 8.0 or higher.
- Transferring save data is only possible for users who are linked to the same Nintendo Account.
- Once the save data has been transferred, the save data will be automatically deleted on the source console.
- Save data cannot be merged between users.
How to Transfer Data to a New Nintendo Switch
When both Nintendo Switch consoles are connected and ready for the transfer, you can follow the steps given below.
Access the source Nintendo Switch console where the save data is located and do these steps:
- Go to the Home Menu.
- Select System Settings icon.
- Scroll down and select Data Management.
- On the right pane, select Transfer Your Save Data.
- Select Send Save Data to Another Device.
- Choose the User profile that has the save data you want to transfer.
- Select the save data file you would like to send to the other console.
- Select Send Save Data.
On the target Switch console where the save data will be sent:
- Select System Settings from the Home Menu.
- Scroll down and select Data Management.
- Select Transfer Your Save Data.
- Select Receive Save Data.
- Select OK once the transfer of the save data to Nintendo Switch has been completed.
Important Note Before Transferring User Data Between Nintendo Consoles
Aside from the save data, User data can be transferred between Nintendo Switch consoles. The user must ensure that both consoles have all the following requirements:
- The source console and the target console must be closed to each other and connected to the internet.
- The source system and the target system must have a system menu version of 4.0 or higher.
- The target console should only have a maximum of seven users for the user data from the source system to be transferred successfully.
- The source system and target system need to transfer user information and save data.
- The target system must have enough free space to accommodate user data files from the source system.
- Any downloadable software purchased by the user you intend to move will not be available on the source console after the transfer is completed.
How to Transfer Your User Data to a Different Nintendo Switch
After the source system and the target system are ready, you can begin to transfer your user data by the steps below.
From the source Nintendo Switch console:
- Select System Settings on the Home Menu of the Nintendo console.
- Scroll down and select Users.
- Choose Transfer Your User on the right pane.
- Click Next.
- Select Next again.
- Select Source Console.
- Click Continue.
On the target Nintendo Switch console:
- Select System Settings from the Home Menu.
- Select Users.
- Choose Transfer Your User.
- Click Next.
- Click Next again.
- Select Target Console.
- Choose Sign In and enter your Nintendo Account login credentials.
- Click Next.
Go back to the source Nintendo Switch:
- Once the target console is detected, select Transfer.
- Select End after the transfer of data is complete. The data should now be automatically removed from the source console.
- How To Fix Fortnite CE-34878-0 Error | PS4 | New & Updated 2021
- How To Disable Nintendo Switch Lock Screen | NEW & Updated 2021
- How To Fix Ghost Of Tsushima CE-34878-0 Error | NEW & Updated 2021
- How To Fix Nintendo Switch Joy-Con Charging Grip Not Working | 2021
Visit our TheDroidGuy Youtube Channel for more troubleshooting videos and tutorials.