text:
Background: In retinitis pigmentosa (RP) rod photoreceptors degenerate from one of many mutations after which cones are compromised by oxidative stress. N-acetylcysteine (NAC) reduces oxidative damage and increases cone function/survival in RP models. We tested the safety, tolerability, and visual function effects of oral NAC in RP patients. Methods: Subjects (n = 10 per cohort) received 600 mg (cohort 1), 1200 mg (cohort 2), or 1800 mg (cohort 3) NAC BID for 12 weeks and then TID for 12 weeks. Best-corrected visual acuity (BCVA), macular sensitivity, ellipsoid zone (EZ) width, and aqueous NAC were measured. Linear mixed effects models were used to estimate the rates of changes during the treatment period. Results: There were 9 drug-related gastrointestinal adverse events which resolved spontaneously or with dose reduction (MTD 1800 mg bid). During the 24 week treatment period, mean BCVA significantly improved at 0.4 (95% CI 0.2–0.6, P < 0.001), 0.5 (95% CI 0.3–0.7, P < 0.001) and 0.2 (95% CI 0.02–0.4, P = 0.03) letters/month in cohorts 1, 2 and 3, respectively. There was no significant improvement in mean sensitivity (MS) over time in cohorts 1 and 2, but there was in cohort 3 (0.15 dB/month, 95%CI 0.04–0.26). There was no significant change in mean EZ width in any cohort. Conclusion: Oral NAC is safe and well-tolerated in patients with moderately advanced RP and may improve suboptimally functioning macular cones. A randomized, placebo-controlled trial is needed to determine if oral NAC can provide long term stabilization and/or improvement in visual function in patients with RP.
Peter A. Campochiaro, Mustafa Iftikhar, Gulnar Hafiz, Anam Akhlaq, Grace Tsai, Dagmar Wehling, Lili Lu, G. Michael Wall, Mandeep S. Singh, Xiangrong Kong
Increases in the number of cell therapies in the preclinical and clinical phases have prompted the need for reliable and non-invasive assays to validate transplant function in clinical biomanufacturing. We developed a robust characterization methodology composed of quantitative bright-field absorbance microscopy (QBAM) and deep neural networks (DNNs) to non-invasively predict tissue function and cellular donor identity. The methodology was validated using clinical-grade induced pluripotent stem cell derived retinal pigment epithelial cells (iPSC-RPE). QBAM images of iPSC-RPE were used to train DNNs that predicted iPSC-RPE monolayer transepithelial resistance, predicted polarized vascular endothelial growth factor (VEGF) secretion, and matched iPSC-RPE monolayers to the stem cell donors. DNN predictions were supplemented with traditional machine learning algorithms that identified shape and texture features of single cells that were used to predict tissue function and iPSC donor identity. These results demonstrate non-invasive cell therapy characterization can be achieved with QBAM and machine learning.
Nicholas J. Schaub, Nathan A. Hotaling, Petre Manescu, Sarala Padi, Qin Wan, Ruchi Sharma, Aman George, Joe Chalfoun, Mylene Simon, Mohamed Ouladi, Carl G. Simon, Jr., Peter Bajcsy, Kapil Bharti
Mutations in genes encoding components of the mitochondrial DNA (mtDNA) replication machinery cause mtDNA depletion syndromes (MDS), which associate ocular features with severe neurological syndromes. Here, we identified heterozygous missense mutations in SSBP1 in five unrelated families, leading to the R38Q and R107Q amino-acid changes in the mitochondrial single-stranded DNA-binding protein, a crucial protein involved in mtDNA replication. All affected individuals presented optic atrophy, associated with foveopathy in half of the cases. To uncover the structural features underlying SSBP1 mutations, we determined a new revised SSBP1 crystal structure. Structural analysis suggests that both mutations affect dimer interactions and presumably distort the DNA binding region. Using patient fibroblasts, we validated that the R38Q variant destabilizes SSBP1 dimer/tetramer formation, affects mtDNA replication and induces mtDNA depletion. Our study, showing that mutations in SSBP1 cause a novel form of dominant optic atrophy frequently accompanied with foveopathy, brings new insights into mtDNA maintenance disorders.
Camille Piro-Mégy, Emmanuelle Sarzi, Aleix Tarrés-Solé, Marie Péquignot, Fenna Hensen, Mélanie Quilès, Gaël Manes, Arka Chakraborty, Audrey Sénéchal, Béatrice Bocquet, Chantal Cazevieille, Agathe Roubertie, Agnès Müller, Majida Charif, David Goudenège, Guy Lenaers, Helmut Wilhelm, Ulrich Kellner, Nicole Weisschuh, Bernd Wissinger, Xavier Zanlonghi, Christian Hamel, Johannes N. Spelbrink, Maria Solà, Cécile Delettre
Inherited optic neuropathies include complex phenotypes, mostly driven by mitochondrial dysfunction. We report an optic atrophy spectrum disorder, including retinal macular dystrophy and kidney insufficiency leading to transplantation, associated with mitochondrial DNA (mtDNA) depletion without accumulation of multiple deletions. By whole-exome sequencing, we identified mutations affecting the mitochondrial single strand binding protein (SSBP1) in four families with dominant and one with recessive inheritance. We show that SSBP1 mutations in patient-derived fibroblasts variably affect its amount and alter multimer formation, but not the binding to ssDNA. SSBP1 mutations impaired mtDNA, nucleoids and 7S-DNA amounts as well as mtDNA replication, impacting replisome machinery. The variable mtDNA depletion in cells reflected in severity of mitochondrial dysfunction, including respiratory efficiency, OXPHOS subunits and complexes amount and assembly. mtDNA depletion and cytochrome c oxidase-negative cells were found ex-vivo in biopsies of affected tissues, like kidney and skeletal muscle. Reduced efficiency of mtDNA replication was also reproduced in vitro, confirming the pathogenic mechanism. Furthermore, ssbp1 suppression in zebrafish induced signs of nephropathy and reduced optic nerve size, the latter phenotype complemented by wild-type mRNA but not by SSBP1 mutant transcripts. This previously unrecognized disease of mtDNA maintenance implicates SSBP1 mutations as cause of human pathology.
Valentina Del Dotto, Farid Ullah, Ivano Di Meo, Pamela Magini, Mirjana Gusic, Alessandra Maresca, Leonardo Caporali, Flavia Palombo, Francesca Tagliavini, Evan H. Baugh, Bertil Macao, Zsolt Szilagyi, Camille Péron, Margaret A. Gustafson, Kamal Khan, Chiara La Morgia, Piero Barboni, Michele Carbonelli, Maria Lucia Valentino, Rocco Liguori, Vandana Shashi, Jennifer A. Sullivan, Shashi Nagaraj, Mays El-Dairi, Alessandro Iannaccone, Ioana Cutcutache, Enrico Bertini, Rosalba Carrozzo, Francesco Emma, Francesca Diomedi-Camassei, Claudia Zanna, Martin Armstrong, Matthew J Page, Sylvia Boesch, Saskia B. Wortmann, Robert Kopajtich, Nicholas Stong, Wolfgang Sperl, Erica Davis, William C. Copeland, Marco Seri, Maria Falkenberg, Holger Prokisch, Nicholas Katsanis, Valeria Tiranti, Tommaso Pippucci, Valerio Carelli
The majority of patients with diabetic macular edema (DME), the most common cause of vision loss in working-age Americans, do not respond adequately to current therapies targeting VEGFA. Here, we show that expression of angiopoietin-like 4 (ANGPTL4), a HIF-1–regulated gene product, is increased in the eyes of diabetic mice and patients with DME. We observed that ANGPTL4 and VEGF act synergistically to destabilize the retinal vascular barrier. Interestingly, while ANGPTL4 modestly enhanced tyrosine phosphorylation of VEGF receptor 2, promotion of vascular permeability by ANGPTL4 was independent of this receptor. Instead, we found that ANGPTL4 binds directly to neuropilin 1 (NRP1) and NRP2 on endothelial cells (ECs), leading to rapid activation of the RhoA/ROCK signaling pathway and breakdown of EC-EC junctions. Treatment with a soluble fragment of NRP1 (sNRP1) prevented ANGPTL4 from binding to NRP1 and blocked ANGPTL4-induced activation of RhoA as well as EC permeability in vitro and retinal vascular leakage in diabetic animals in vivo. In addition, sNRP1 reduced the stimulation of EC permeability by aqueous fluid from patients with DME. Collectively, these data identify the ANGPTL4/NRP/RhoA pathway as a therapeutic target for the treatment of DME.
Akrit Sodhi, Tao Ma, Deepak Menon, Monika Deshpande, Kathleen Jee, Aumreetam Dinabandhu, Jordan Vancel, Daoyuan Lu, Silvia Montaner
Polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA) positively affect the outcome of retinopathy of prematurity (ROP). Given that DHA metabolism by cytochrome P450 and soluble epoxide hydrolase (sEH) enzymes affects retinal angiogenesis and vascular stability we investigated the role of sEH in a mouse model of ROP. In wild-type mice, hyperoxia elicited the tyrosine nitration and inhibition of the sEH and decreased generation of the DHA-derived diol 19,20-dihydroxydocosapentaenoic acid (DHDP). Correspondingly in a murine model of ROP, sEH–/– mice developed a larger central avascular zone and peripheral pathological vascular tuft formation than their wild-type littermates. Astrocytes were the cells most affected by sEH deletion and hyperoxia increased astrocyte apoptosis. In rescue experiments 19,20-DHDP prevented astrocyte loss by targeting the mitochondrial membrane to prevent the hyperoxia-induced dissociation of presenilin-1 (PS-1) and PS-1 associated protein (PSAP) to attenuate PARP1 activation and mitochondrial DNA damage. Therapeutic intravitreal administration of 19,20-DHDP not only suppressed astrocyte loss but also reduced pathological vascular tuft formation in sEH–/– mice. Our data indicate that sEH activity is required for mitochondrial integrity and retinal astrocyte survival in ROP. Moreover, 19,20-DHDP may be more effective than DHA as a nutritional supplement at preventing retinopathy in preterm infants.
Jiong Hu, Sofia Iris Bibli, Janina Wittig, Sven Zukunft, Jihong Lin, Hans-Peter Hammes, Rüdiger Popp, Ingrid Fleming
There has been great progress in ocular gene therapy, but delivery of viral vectors to the retinal pigmented epithelium (RPE) and retina can be challenging. Subretinal injection, the preferred route of delivery for most applications, requires a surgical procedure that has risks. Herein we report a novel gene therapy delivery approach, suprachoroidal injection of AAV8 vectors, which is less invasive and could be done in an outpatient setting. Two weeks after suprachoroidal injection of AAV8.GFP in rats, GFP fluorescence covered 18.9% of RPE flat mounts and extended entirely around sagittal and transverse sections in RPE and photoreceptors. After 2 suprachoroidal injections of AAV8.GFP, GFP fluorescence covered 30.5% of RPE flat mounts. Similarly, widespread expression of GFP occurred in nonhuman primate and pig eyes after suprachoroidal injection of AAV8.GFP. Compared with subretinal injection in rats of RGX-314, an AAV8 vector expressing an anti-VEGF Fab, suprachoroidal injection of the same dose of RGX-314 resulted in similar expression of anti-VEGF Fab and similar suppression of VEGF-induced vascular leakage. Suprachoroidal AAV8 vector injection provides a noninvasive outpatient procedure to obtain widespread transgene expression in retina and RPE.
Kun Ding, Jikui Shen, Zibran Hafiz, Sean F. Hackett, Raquel Lima e Silva, Mahmood Khan, Valeria E. Lorenc, Daiqin Chen, Rishi Chadha, Minie Zhang, Sherri Van Everen, Nicholas Buss, Michele Fiscella, Olivier Danos, Peter A. Campochiaro
Inherited retinal degenerations are a common cause of untreatable blindness worldwide, with retinitis pigmentosa and cone dystrophy affecting approximately 1 in 3500 and 1 in 10,000 individuals, respectively. A major limitation to the development of effective therapies is the lack of availability of animal models that fully replicate the human condition. Particularly for cone disorders, rodent, canine, and feline models with no true macula have substantive limitations. By contrast, the cone-rich macula of a nonhuman primate (NHP) closely mirrors that of the human retina. Consequently, well-defined NHP models of heritable retinal diseases, particularly cone disorders that are predictive of human conditions, are necessary to more efficiently advance new therapies for patients. We have identified 4 related NHPs at the California National Primate Research Center with visual impairment and findings from clinical ophthalmic examination, advanced retinal imaging, and electrophysiology consistent with achromatopsia. Genetic sequencing confirmed a homozygous R565Q missense mutation in the catalytic domain of PDE6C, a cone-specific phototransduction enzyme associated with achromatopsia in humans. Biochemical studies demonstrate that the mutant mRNA is translated into a stable protein that displays normal cellular localization but is unable to hydrolyze cyclic GMP (cGMP). This NHP model of a cone disorder will not only serve as a therapeutic testing ground for achromatopsia gene replacement, but also for optimization of gene editing in the macula and of cone cell replacement in general.
Ala Moshiri, Rui Chen, Soohyun Kim, R. Alan Harris, Yumei Li, Muthuswamy Raveendran, Sarah Davis, Qingnan Liang, Ori Pomerantz, Jun Wang, Laura Garzel, Ashley Cameron, Glenn Yiu, J. Timothy Stout, Yijun Huang, Christopher J. Murphy, Jeffrey Roberts, Kota N. Gopalakrishna, Kimberly Boyd, Nikolai O. Artemyev, Jeffrey Rogers, Sara M. Thomasy
Mutations in CNGA3 and CNGB3, the genes encoding the subunits of the tetrameric cone photoreceptor cyclic nucleotide–gated ion channel, cause achromatopsia, a congenital retinal disorder characterized by loss of cone function. However, a small number of patients carrying the CNGB3/c.1208G>A;p.R403Q mutation present with a variable retinal phenotype ranging from complete and incomplete achromatopsia to moderate cone dysfunction or progressive cone dystrophy. By exploring a large patient cohort and published cases, we identified 16 unrelated individuals who were homozygous or (compound-)heterozygous for the CNGB3/c.1208G>A;p.R403Q mutation. In-depth genetic and clinical analysis revealed a co-occurrence of a mutant CNGA3 allele in a high proportion of these patients (10 of 16), likely contributing to the disease phenotype. To verify these findings, we generated a Cngb3R403Q/R403Q mouse model, which was crossbred with Cnga3-deficient (Cnga3–/–) mice to obtain triallelic Cnga3+/– Cngb3R403Q/R403Q mutants. As in human subjects, there was a striking genotype-phenotype correlation, since the presence of 1 Cnga3-null allele exacerbated the cone dystrophy phenotype in Cngb3R403Q/R403Q mice. These findings strongly suggest a digenic and triallelic inheritance pattern in a subset of patients with achromatopsia/severe cone dystrophy linked to the CNGB3/p.R403Q mutation, with important implications for diagnosis, prognosis, and genetic counseling.
Markus Burkard, Susanne Kohl, Timm Krätzig, Naoyuki Tanimoto, Christina Brennenstuhl, Anne E. Bausch, Katrin Junger, Peggy Reuter, Vithiyanjali Sothilingam, Susanne C. Beck, Gesine Huber, Xi-Qin Ding, Anja K. Mayer, Britta Baumann, Nicole Weisschuh, Ditta Zobor, Gesa-Astrid Hahn, Ulrich Kellner, Sascha Venturelli, Elvir Becirovic, Peter Charbel Issa, Robert K. Koenekoop, Günther Rudolph, John Heckenlively, Paul Sieving, Richard G. Weleber, Christian Hamel, Xiangang Zong, Martin Biel, Robert Lukowski, Matthias W. Seeliger, Stylianos Michalakis, Bernd Wissinger, Peter Ruth
Ciliopathies are clinically overlapping genetic disorders involving structural and functional abnormalities of cilia. Currently, there are no small-molecule drugs available to treat ciliary defects in ciliopathies. Our phenotype-based screen identified the flavonoid eupatilin and its analogs as lead compounds for developing ciliopathy medication. CEP290, a gene mutated in several ciliopathies, encodes a protein that forms a complex with NPHP5 to support the function of the ciliary transition zone. Eupatilin relieved ciliogenesis and ciliary receptor delivery defects resulting from deletion of CEP290. In rd16 mice harboring a blinding Cep290 in-frame deletion, eupatilin treatment improved both opsin transport to the photoreceptor outer segment and electrophysiological responses of the retina to light stimulation. The rescue effect was due to eupatilin-mediated inhibition of calmodulin binding to NPHP5, which promoted NPHP5 recruitment to the ciliary base. Our results suggest that deficiency of a ciliopathy protein could be mitigated by small-molecule compounds that target other ciliary components that interact with the ciliopathy protein.
Yong Joon Kim, Sungsoo Kim, Yooju Jung, Eunji Jung, Ho Jeong Kwon, Joon Kim


text:
| 11°C Belfast
More than 34 million people will this year fail to get an appointment with their GP when they seek one, the Royal College of General Practitioners (RCGP) has claimed.
The college's prediction that one in ten prospective patients will fail to secure an appointment when they wish is based on analysis of the latest GP Patient Survey, which was published in December.
The RCGP said the number of people who would fail to get an GP appointment when they want one will continue to rise as Government cuts and the effects of an ageing population take hold.
GPs now see 340 million patients per year in total but t he NHS budget for general practice has been cut by £9.1 billion in real terms since 2004, the college said.
Each GP is handling 1,500 more consultations a year than in 2008.
The GP Patient Survey on which the predictions are based asked patients whether they were able to get an appointment to see or speak to someone in general practice.
The responses showed an increase in the number of patients failing to secure an appointment at all from 9% of patients, in the version of the survey published in June 2012, to 10% in the latest report - equivalent to an increase of 3.4 million patients annually.
The RCGP called on the Government to increase the proportion of the NHS budget spent on general practice from 8.5% to 11% by 2017.
RCGP chair Dr Maureen Baker said: "The unprecedented decline in funding for healthcare in the community has brought general practice to its knees.
"GPs and practice nurses want to provide high-quality care for every single patient who seeks a consultation, and over the last decade we have increased the number of patients we see each year in England by 40 million.
"However, GPs and practice nurses can't keep doing more for less and now that funding for general practice in England has slumped to just 8.5% of the NHS budget the service we provide is in crisis.
"All three political parties say they want to see more patients being treated in the community, where care can be provided to patients more economically, in their own surroundings, and yet resources are increasingly being diverted away from communities and into hospitals.
"By continually diverting resources into hospitals, we have fuelled a real and growing crisis in general practice."
She added: "If the Government and NHS England really want to give general practice the tools to provide high-quality and comprehensive care in the community, they must increase funding for the sector to 11% of the NHS budget by 2017."
Shadow health secretary Andy Burnham blamed Prime Minister David Cameron for scrapping Labour's guarantee of a GP appointment within 48 hours.
He said: "Within days of taking office, David Cameron scrapped Labour's guarantee that all patients shou ld be able to get a GP appointment within two working days.
"In December, Labour called on the Government to reverse this decision but Tory MPs voted against. It is one of the reasons why A&E departments are now under such pressure.
"Ministers have cut primary care budgets by close to a billion since the election and taken away the funding that kept surgeries open into the evening and at weekends.
"Now, almost 1,000 surgeries across England shut their doors earlier than a few years ago.
"On David Cameron's watch, it has got harder for people to get GP appointments.
"Patients call the surgery early in the morning only to be told nothing is available for days. It is unacceptable and ministers must take practical steps to make sure patients can see their GP when they need to."
The Department of Health (DH) described the RCGP's claims as "complete nonsense" based on misleading extrapolations of data.
The DH said the college was conflating the number of patients with the number of visits to a GP and that the figure of 34 million was based on 10% of survey respondents saying they could not see someone on a specific occasion, rather than over the whole year.
A spokeswoman said: "It's complete nonsense to suggest that 34 million people won't be able to get an doctor's appointment this year. Misleading extrapolations of partial data have been used to generate a sensationalist headline. The GP survey showed the vast majority of patients are satisfied with their GP and rated their experience of making an appointment as good.
"We know how hard GPs work. That is why we are freeing them from excessive box-ticking so that they can devote more time to patients. We have also provided £50 million to help innovative GPs modernise their services and stay open longer, to meet the needs of patients with busy lives."

subset: commoncrawl


text:
This page is restricted to registered members only.
First-time user? Register now to receive FREE email contest updates, news, results, deadline reminders and more. Rest assured, information submitted here is held in strict confidence. MovieBytes never sells or in any way distributes email names or addresses. We promise!
If you've forgotten your password, please request our password reset instructions.


text:
If you're looking to transfer SMS from iPhone to Android device, Backuptrans iPhone SMS to Android Transfer is a good choice which lets you do it in only one single click. It is designed to transfer iPhone SMS to Android phone directly. Connect both your iPhone and android phone to computer, and you will get it done in a few seconds. Users can choose to either transfer all SMS from iPhone to Android phone or just transfer the SMS with a certain friend as you want. Besides, you can also choose to transfer SMS into android from iTunes backup if you once backed up your iPhone data with your iTunes library.
1 Transfer SMS from iPhone to Android
2 Transfer SMS to Android from iTunes Backup
3 Save iPhone SMS to local database on computer
4 Copy SMS from PC local database to Android
5 Export iPhone SMS to document files such as txt, csv, doc or html
6 Print out iPhone SMS messages in conversations
7 iMessage supported also
Read more: http://www.backuptrans.com/iphone-sms-to-android-transfer.html
Free Download it to try.


text:
Celestial Seasonings® - Bengal SpiceHerb Tea
Bengal Spice has a sweet, creamy flavor that adds a sumptuous quality to this medley of herbs and spices!
This zesty blend is an exotic taste adventure with cinnamon, ginger and cardamom to awaken your senses. A hint of vanilla smoothes the flavor and adds a bit of sweetness.Discover the treasure of sweet and spicy flavor in a simmering mug of 100% natural Bengal Spice. Add a touch of cream or milk to treat yourself to the traditional serving of Indian spiced tea.


text:
Pat Denevan, Tom Rust, Chris Carillo, Paul Sussman, Steve Rodrigues, Dave Kiesling, Rob Johnson, Wayne Michelsen, Dave Eggli, Charlie Nelson, George Artz, Urs Kellenberger, Ken Martin, Tom White
President reports tonight's meeting will include 1st vote on revision to bylaws to increase maximum suspension by club officer to up to 14 days. A pilot was intending to bypass club protocol to complain to other authorities regarding an alleged violation of club rules, situation was diffused. Disciplinary hearing scheduled regarding above complaint, hearing will be fair and without prejudice. Reported on Fellow Feathers / BAPA negotiations toward agreement between clubs, and upcoming SUP renewals.
Rob Johnson will chair next months meeting in Ken Martins absence.
V.P. reports there will be upcoming work party on some clubhouse maintenance.
Treasurer reports bank balance of $15,443., will be $15,673 after additional deposits.
Club House Mgr reports there is a n ew dent in north side of building.
Safety Officer reports no recent incidents. "Rope Dance" training concept brought up for discussion.
Tech - Ken reports that the website is stable at this time.
Tandem Admin reports that all tandem pilot's equipment has been inspected, including flying wires, harnesses, emergency parachutes, and there are now holographic sticks on gliders cross bars.
Training Bowl Admin reports no recent training activity in bowl.
Motion was forwarded regarding increasing officer's ability to issue suspensions for up to 14 days, motion seconded. Secret ballot vote was taken, results were tallied by Dave Eggli. Motion passed 11 yes votes to 2 no votes. second vote will occur at next month's meeting.
Meeting adjourned.


text:
Some Great Contract Hire and car Leasing Offers on all Lexus Vehicles, Click the deals below to view the great lease deals on on the Lexus car range.
Donnelly Fleet has some fantastic contract hire and car leasing deals on all Lexus for both business and personal customers, choose one of the many special offers we currently have on our Lexus deals page.
Click on the images below to view our fantastic Personal contract hire deals on the Lexus range.
We can provide a quotation on any model so if you cant see what you are looking for then click here to get a quote.
* All vehicle images and car descriptions on this site are for illustration and reference purposes only and are not necessarily an accurate representation of the vehicle on offer.
E: firstname.lastname@example.com
Donnelly Fleet
45 Mallusk Rd
County Antrim
Donnelly Fleet are a credit broker and not a lender, Donnelly Fleet. {Firm Reference Number 477572} are an appointed representative of Donnelly Bros Garages {Dungannon} who are authorised and regulated by the Financial Conduct Authority. Registered No : 311440
Registered in Northern Ireland with company number : NI41870 | Data Protection No : Z1601346 | VAT No : GB783025923
Registered Office : 59 Moy Road, Dungannon, County Tyrone, BT71 7DT
Copyright © 2020 Donnelly Fleet, All rights reserved.


text:
Bow Tie thick black Twill - Adult
BOW-TEE Bow Tie to insert on your BOW-TEE Tee-shirts.
Made in France.
Recipient :
* Required fields
or Cancel
Bow Tie for BOW-TEE T-shirt only.
Same material also available for kids.
Dry wash only.
|55 mm
|105 mm
Shipping & Handling Charges for your BOW-TEE products
Orders of 100€ and over are qualified for FREE SHIPPING.
For all the other orders, please refer to the price-list to check the cost of your parcel regarding the shipping company choosen.
All returns must be authorized by us before sending merchandise back. Simply navigate to your Order History page to request a return authorization number within 7 days of the orders delivery date.
As an exception for the holidays we are extending our return period.
Underwear, swimwear, and merchandise marked final sale cannot be returned.
The merchandise must not be worn, altered or washed. Merchandise must be returned in its original condition, and accompanied by its original tags. Merchandise returned damaged may be rejected and sent back to the customer at the discretion of SSENSE. Footwear must also be accompanied by the original shoe box in its original condition.
Original shipping fees are not refundable. A refund will be issued back to the original method of payment for the merchandise returned. We require up to 5 business days of receiving the merchandise at the SSENSE warehouse. Financial institutions may require additional days to process the refund before the funds are returned to the account.
The return authorization number must be clearly written on the outside of the package. Additionally, returns should be shipped with a service that provides a tracking number and insurance as we are not responsible for delayed or lost packages. Any returns received without a return authorization number or that do not comply with the above may be denied at the discretion of SSENSE.
All returned merchandise should be declared as a "Return of Canadian Merchandise" on the customs declaration; without this the return may not be successful or may incur additional fees.
Complete return instructions will be provided upon request of a return authorization number - simply navigate to your Order History page to request a return.


text:
Wine Kat necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 299 diseños de 76 diseñadores freelance.
the girls in the vineyard
We make beautiful Cabernet and Sauvignon Blanc from Northern California. Our wines are balanced, fresh & lovely. We follow very old world traditions, but with an innovative approach. We are a little irreverent, but never silly...we are a luxury product that over deliveries for its $20 price point.
The "girls" are the vines themselves.
Primarily US wine consumers 25 years old on...
We have a strong following of woman between 38 - 60, but also have a loyal male following that is some what smaller.
We sell both to business that re-sell our wine (restaurants and fine retailers) and direct to consumers from our website and mailing list.
We need a label that stands out in a crowded market segment.
It needs to have shelf appeal.
Think...luxury perfume.
It can not can alienate our male customers.
The name is always in lower case.
We do like the "g" in our present design, but nothing else.
Want something graphically strong that can be carried through to other print and marketing mediums (web, biz cards)
Do not use the color BLUE.
Red is a good accent color.
The label needs to contain a vintage date (2007).
Modern, yet elegant...
It can run vertically, horizontally or be in several parts.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


text:
ST2 Motor Conversion Kit
Motor Conversion Kit ASI L1e-B ST2 ST2 & LTD ST2
To update 2018 bikes to TDCM motors
We are the master technician and official UK importer for all Stromer OEM Products.
- Free UK Mainland Delivery
- Registration and Assembly included
- Ready to ride
- Delivery to Desk or Door
- We handle all paperwork and registration
All bikes are delivered fully assembled, registered and ready to ride. Delivery is free to the UK Mainland.
You can ride away on the day of delivery.
We take care of all paperwork for registration, letting you spend more time enjoying the thrill of your newly acquired Stromer.
All deliveries are made by our dedicated in house team. They will set the bike up with you, giving you a full hand over so that you are happy and confident the bike is perfectly tuned to you and your ride style.
|Frame Size
|Rider Height
|Up to 175cm
|175 - 185cm
Test Rides
Riding a Stromer is exhilarating. Everyone should have the opportunity to experience. We can arrange at home or at office test rides and bring everything to you. Call us on 01797 360283 or email@example.com.
0% Finance
We offer 12 month, 0% finance to help you get on the road even quicker. Contact us to arrange your 10% deposit.


text:
Regular price €93,00
A little word from the designer:
"The name of these smocks is Diademe. If you take a close look, you will see recognize the shape of a half crown looking like those worn by princesses and adorned with precious jewels. May this dress make your darling feel very royal!"
Composition: 100% brushed cotton
Free shipping in Europe - Dress available in our Parisian baby and children boutique L'Île aux Fées - 66 rue Notre Dame des Champs 75006 Paris France
Size Guide
Care & cleaning tips
Cleaning advice
All our garments can be machine.
We recommend to wash smocked dress at 30°C preferably on a delicate cycle.
Please turn the dresses inside out and wash with similar colours.
Hang dry and avoid tumble drying.
Traditional couture & smocks expertise
Uniting timeless French style with traditional handsmocking, our dresses are one of a kind. Time-honored know-hows of dressmaking are practiced in our very own atelier by our team of experts who bring each piece to life.
Pioneers in marrying nouveau French style with the traditional smocking art of Madagascar and have been dedicated to the craft for over three decades. Deeply treasured, we are commited to the safe-keeping of this precious heritage.
For striped and checked fabrics, we pleat the fabric entirely by hand so as to put forward one color. The same goes for velvets so as to achieve greated precision. Nothing is left to chance. We believe there is no age to enjoy well made clothes. Your children deserve perfection.
Once pleated, the fabric is then smocked entirely by hand too. This skill is passed down from generation to generation within our atelier. Offering unlimited possibilities, smocks enhance our creativity. Each season is a new opportunity to experiment and renew our designs. Inspiration is gleaned from nature's beauty, cherished childhood memories, and most of all French culture. Our Parisian boutique L'Île aux Fées' surrounding is a constant source of amazement and new ideas.
All our embroideries are traditionally made with embroidery hoops. We call the result "needle painting" due to its delicacy. Thanks to this ancient know-how we achieve great precision and sophistication.
At every step and up until the very last stitch, great care is provided. The wrong side is almost as clean as the right side.
Our hems are also made by hand in order to obtain an invisible seam. Even our buttons are self covered by hand!


text:
To my beautiful son:
It's hard to know how to start this letter, but I find myself needing to write to you on this World AIDS Day about my having HIV. Right now in 2012, you are only 3 years old and much too young to understand what it means for your mom to be living with HIV. There is a big part of me that wishes I could protect you from knowing for as long as possible, but I know that I cannot keep it a secret from you forever, and that trying to will not make it go away and will only create barriers and make it seem shameful. So, I am publishing this letter on this World AIDS Day to help others who need to and want to understand more about what it's like to have HIV. But, I am doing so under a pseudonym to protect you from any stigma and discrimination that you do not deserve simply because you are my son.
The theme for World AIDS Day this year is "Getting to Zero", meaning zero new infections and zero new AIDS diagnosis. When I found out that I had HIV at age 22, it was 1990, and the idea that we could stop people from getting sick and infected with HIV was not even a glimmer of hope. Back then, when I was told that I was HIV positive, there was very little hope. In the 1980s and 1990s, people were dying all around me, there were no good treatments for the virus and the transmission of HIV from a mother to her child was 25-40 percent. When I was diagnosed, a swirl of feelings overtook me—shame, fear, guilt and loss; the one clear thought that emerged was, "I will never be able to have children." On that day, I just wanted my own mother to come and get me and comfort me. I remember seeing the tears that had fallen to my hand and being so afraid that she would not want to touch me. But she did. On that day, she took me up in her arms and we sat there together and cried. She knew that the HIV virus does not punish or discriminate, and most of all, she understood I had nothing to be ashamed of. I was so very lucky to have her support.
After my diagnosis, I was so afraid of people finding out and what they would say about me. Instead of keeping it a secret, I decided to disclose my status very publically to help other young people, especially young women. Speaking to the media, writing my story for publication and speaking to teenagers to help them not get infected were how I got out my message. But as I grew older and didn't die, I found that I didn't need people to only know that about me, and I came to believe that my HIV status wasn't the only way that I could be defined. I had so much more to offer the world. And so will you.
But, as I grew older, I did wonder more and more about who I should tell and when. Did I need to tell my yoga teacher? Did acquaintances I made in my graduate master's program need to know? I started to resist being just defined by this very difficult experience of having HIV, and it was freeing not to feel that I had to tell everyone. My loving husband, your father knows. And now so do you.
You just turned 3. It is an amazing time to experience your growing and changing every day. You are truly delightful, spirited and forming a sense of yourself. There is a sweetness that is emerging—sensitivity and inquisitiveness. You want to know why things happen, how they happen, what the reasons are … anything from why it rains to why do dogs lick you, or why Dracula is scary and why you sometimes get mad (and don't know how to express your feelings well enough verbally). Soon you will want to know about the pills your mom takes and about the doctor's appointments she has to keep. I promise to keep answering your questions and that when you start to ask about my HIV, I will answer them with honesty, kindness and thoughtfully. That is what family means. Honesty, openness and unconditional love.
Growing up, I didn't learn much about my body, that there were STDs and HIV that I could get – a lot of families don't know how to talk about sex. I wish that my family had known how to help me to respect myself more and learn about my sexual health. You can count on your father and me to talk with you when the time is right about the importance of you as a whole person and sexual being, and we will tell you that you have a right to honor your own body and you have the responsibility to honor and respect others' bodies too. One of the places where I think we can help "get to zero" is to encourage families to start talking about sexual health, including HIV in their homes. I am hoping that your knowledge of HIV and what it means for me, you and our family will be a natural part of our conversations together. One that changes and develops as you grow older and can understand more.
When I became pregnant with you, 18 years after my diagnosis, I was very open with my doctors, close friends and my own family. I wanted more than anything to make sure that you would be born without the HIV virus in your body. Waiting for your first test results was one of the hardest days in my life. You were born free of HIV. Thanks to my medical care, the chances of you not having it were 99 percent. Nonetheless, I still worried about that 1 percent.
Now that you are getting older, I am starting to think about our community, and how our family with my HIV fits into it. I haven't disclosed my status to people who are close to us, but that is partially because I am sometimes afraid of people's reactions, being pitied, judged or even feared. Telling others I have HIV is not something that comes up easily in conversations with other parents at the park, soccer class or at the pool. Yet, now that you are getting older, I have to be brave and work to create as safe a space as I can in your family and community to be able to talk about HIV. I will work to create an environment that supports safe and voluntary disclosure of HIV for me and for the millions others like me.
I am already so proud of your loving kindness and open heart. I know that our family, including you, will help our world "get to zero." You can count on me to continue taking care of myself and by being honest and speaking out; and by taking my medications, seeing my doctors, and most of all by sharing my story.
On this World AIDS Day, I want you to know that my story will always include you, my wonderful and healthy son.
Love forever,
Your proud mom
Originally published in the Altarum Health Policy Forum, a weekly journal for debate and discussion about health care and health policy.


text:
CG - 4x6 Box for Ephemera
Price: $3.00
4x6 box designed to add decorative prints, labels and emphemera on top. Sides of the lid have a cutout pattern for a finished touch.
"I don't know about you but I just LOVE the Ephemera Cards from Graphic 45. So I decided to make a little box that you could make and highlight a 4x6 ephemera card." ~ Cyndy
Designed by Cyndy G. Time Made For Me
DIGITAL DOWNLOAD ONLY. No physical product is sent.
Every design in AI, DXF, GSD and SVG cuts beautifully on your DIY electronic cutter. Printable PDF patterns also included with all pieces labeled and for use when printing pattern for hand cutting.
Cleanest cutting paper craft files for all the popular paper cutting machines.
Works with.....
- Sillouette™ Use GSDs in Cameo's basic edition software. Use SVGs for Cameo's Designer edition software and above.
- Cricut™ Use SVGs to import to Cricut's Design Space online software.
- Brother Scan-N-Cut Use SVGs by importing to ScanNCut's online Canvas software. Note: Set mat size to 12" x 24" to guarantee accurate sizing.
- Pazzles Inspiration™
- Klick-n-kut™
- Silver Bullet™
- BlackCat Cougar/Lynx™
- CraftROBO™Wishblade™
- eCraft™
- SCAL - Use SVGs for Sure Cuts A Lot™
- MTC - Use SVGs for Make the Cut™ software


text:
"Our Town" at Central City Opera review: Progressive, literary, and not ridiculous – if you like that sort of thing
That Ned Rorem's 2006 "Our Town" even gets produced is something of a miracle in an opera world where nearly all new inventions disappear a few fast minutes after their premiere.
But the work babbles on by knowing its place. Artful and intellectually driven, it is reasonable fare for the universities, conservatories and small companies that have resurrected it. Life in the operatic underground is still life and maybe the right one for a piece that is set partly in a cemetery and insists that being dead is preferable over walking the earth.
The Central City Opera House isn't exactly a secret haven for opera, though it has its advantages as a home to this work, partly because it takes place in 1906, around the era of the historic building's heyday. But it's more than that.
Based on Thornton Wilder's Pulitzer-winning play, the opera is wholly American, built on optimism, but reckoned by the fact that prosperity is fleeting, that dreams can crash hard. You could say the same thing about the come-and-gone town of Central City itself.


text:
ICUsteps - The intensive care patient support charity
About ICUsteps
ICUsteps was founded in 2005 by ex-patients, their relatives and ICU staff to support patients and their families through the long road to recovery from critical illness.
Our aims are to:
- support patients and relatives affected by critical illness,
- promote recognition of the physical and psychological consequences of critical illness through education of the medical profession and the general public, and
- encourage research into treatment and the prevention of these issues.
ICUsteps is the United Kingdom's only support group for people who have been affected by critical illness and has helped many former patients, their relatives and medical staff from organisations around the world.
Fundraising is a key part of every charity's work. ICUsteps is run entirely by volunteers so all the money we raise goes straight to helping meet our goals of supporting patients and relatives, highlighting the problems they can face following a period of critical illness and helping medical staff improve the treatment and support given both during and following a critical illness.
Help our research
As part of our work in trying to improve aftercare following critical illness we're gathering contact details of former patients and relatives who would be willing to help with research. We're often contacted by medical professionals who want to include the patient perspective in their research and having a group of ex-patients we can contact when we receive requests for help is very valuable.
If you have been affected by critical illness, either as a patient or relative, please help us by looking at our research page and contact us if you're able to help.


text:
It's been a very long time since I have posted. Life has moved by so fast and I just don't have enough time to keep up with blogging or blogland in general. Quick update - Kassidy is in the 8th grade this year and made the junior high volleyball team. I am so proud of her. She amazes me every day. Her team is 3-0. I'm sure some of you have been waiting....so here it goes...I am a Grandma!! Zachary Santos Jr was born on 5/17/2012 weighing just over 6lbs. He's captured our hearts in ways that didn't seem possible. He's the light of our life right now. Momma is doing good as well. She's back to work and started back to college. She's got a full schedule but I have no doubt that she will try hard to make it work. Here is Zachary a week after birth:
Thursday, September 6, 2012
Long time.....
Posted by Danica at 4:51 PM 3 comments
Subscribe to: Posts (Atom)


text:
Ben Joseph necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 77 diseños de 21 diseñadores freelance.
AGS - Arcade Game Sales of Maryland
Our website is http://www.AGSGames.com AGS stands for "Arcade Game Sales." We Sell new and fully restored classic arcade games from the early 80's classic game era to present day machines. These are the full sized coin operated game machines like Pacman, Galaga, Space Invaders and Asteroids.
We will STAY IN CONSTANT CONTACT to give feedback and help you in the development and tweaking. FUTURE BUSINESS OPPORTUNITY for the winner. We will use the winning designer for future development of this logo and other graphic design jobs, etc.
Our target audience is people of all ages who are searching for these types of machines to purchase and place in their home game rooms, basements etc. This is an existing market. We need a catchy logo that will bring out some memories and nostalgia in people that played these games in the arcade, in the past.
LOGO requirements:
-Should use the letters "AGS." Optional to also use these words "Arcade Game Sales" below the letters AGS.
-Letters and potential logo components should incorporate a classic arcade game look and feel. Some suggestions are a futuristic look or pixilated look to the letters (AGS) (not essential if the look is not good to you), or a 3D game character as part of the logo. You could use some type of simple space ship or other simple game character drawling along side or coming out of the side. Such simple space ships, etc were seen on the side art of some classic games. See attachments of asteroids graphics for example of "space ships", etc. Also you could use arcade joysticks or buttons or an entire arcade game cabinet!
Please be original so as not to use any copyrighted characters.
-Check website for some ideas of color coordination: http://www.agsgames.com (Blues, reds, silvers are some possibilities which are on our website.)
-Not absolutely necessary but it would be nice if the logo had some possibility of animating when used in the flash header of our website.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


text:
Store, manage and protect unstructured data with efficiency and massive scalability.
Dell EMC Isilon is the industry's #1 family of scale-out network-attached storage systems1, designed for demanding enterprise file workloads. Choose from all-flash, hybrid and archive NAS platforms.
Accelerate demanding file workloads with extreme performance and efficiency.
Realize performance, capacity, and value for a wide range of enterprise file workloads.
Lower the cost to store and protect aging data assets while providing near-primary accessibility.
Dell EMC Isilon scale-out data storage solutions are powerful, yet simple to scale and manage, no matter how large your unstructured data environment becomes. Unlike traditional storage, Isilon solutions are flexible, efficient and stay simple regardless of how much storage capacity and performance is required, or how your business needs change. Isilon integrates easily with a choice of cloud services and, with built-in data analytics support, allows you to unlock data capital to accelerate the digital transformation of your business.
Simple to manage: Simplify management no matter how large your data becomes
Highly efficient: Consolidate file workloads and cut costs with 80% utilization, automated tiering and data reduction options
Massive scalability: Scale easily from tens of terabytes to tens of petabytes without disruption
Dell EMC OneFS provides enhanced performance with massive scalability to support the most demanding file-based workloads. With Isilon scale-out NAS solutions powered by OneFS, organizations can modernize their data storage infrastructure to support their digital transformation.
IT Brand Pulse 2019 Market Leader: Dell EMC
IT Brand Pulse 2019 Market Leader: Dell EMC
Dell Technologies On Demand offers a consumption-driven, as-a-service optimized business model ideally suited for the way on-premises infrastructure and expertise is consumed in the on-demand economy.
Highly trained experts around the clock and around the globe to address your IT needs, minimize disruptions and maintain a high-level of productivity.
Integrate new technology into existing environments with confidence through extensive planning and validation by expert certified engineers.
Acquire technology on your terms with a variety of flexible payment solutions from Dell Financial Services.**


text:
9 Tips to Get Speaking Opportunities for Women Business LeadersFebruary 12th, 2013
Women Business Leaders Should Look For Speaking Opportunities
Having the opportunity to speak in front of a highly targeted, interested group of prospects is a very effective way to grow your personal brand and business. Even if you are speaking for free, the opportunity oftentimes outweighs a fee when it comes to the potential for new business and establishing yourself as a thought leader.
Here are 9 personal tips to generate speaking opportunities:
1. Start with blog
Your blog can become a great tool to open doors to speak. It provides a the platform to hone your subject matter, draw interest and appeal from your best agency prospects.
People want to work with people that they know, trust and like. Your blog can become the face of your business, the gateway for new business opportunities. It can also be a springboard for speaking opportunities.
2. Create a Speaking Page
Roxanne Joffe speaks on topics related to leadership, business development, and social media. She has been speaking publicly for more than 10 years and has keynoted more than 50 events.
A few suggestions on what to include on your blog's Speakers Page
- Clearly define your expertise and your niche
- Provide a description of topics and presentations you can speak on
- Create your "speakers bio"
- Speaking Engagement. List events where you will be speaking, no matter how small (I would also suggest adding your speaking engagements to your blog's side bar) Speaking Engagements
- Provide testimonials. I've discovered that LinkedIn is an excellent way to generate testimonials
- Be sure and provide your contact information
- Educate and you won't have to sell
3. Shoot Video
Video is easily shot, embedded and/or linked through your blog. It's not that difficult create, and make a big difference in generating new speaking engagements.
4. Record Audio
You can also record video through a number of different programs to upload or link to your blog. Someone recently introduced me to a program that easily records interviews called wetoku. You can also use a service as simple as FreeConferenceCall.com.
5. About Page
I would suggest creating an About Page for your blog that would provide a fuller profile of your experience beyond your speakers bio.
In addition to these tips …
6. Make the Most of Your Presentation Time
Success breeds success
It goes without saying, you need to make a good presentation. Here are a few presentation tips to think about:
- Focus on your audience. Don't sell. Help them, entertain them, inform them and inspire them.
- Prepare and rehearse your presentation.
- Make eye contact and be engaging.
- Use listening notes. Facilitate questions.
- Make your session interactive with your audience.
- Get a look at the presentation room as soon after you arrive as possible. It always helps to be aware of your surroundings and adjust your presentation accordingly.
- Set-up your equipment as early as possible before your presentation time.
- Have a back-up plan if you have technical issues. I always upload a copy of my presentation to an online source, have downloaded it also to a thumb-drive, make sure I have all my adapters, pluggins, etc.
- If at all possible spend time in other conference sessions. Be part of the conference community.
- Provide enlightening personal stories and illustrations.
- If you use PowerPoint or Keynote, don't read the slides! Instead use them illustrate your points. Nice photos/graphics.
- Bring plenty of business cards.
- Provide your contact info at the end of any slide or video presentations.
7. Use Social Tools
In addition to your blog, use social media tools such as Twitter, Facebook and LinkedIn to help promote the event at which you are speaking. This will be a huge help to the event organizers, will make them even more appreciative for your participation and will be a benefit to you by the positive referrals.
Often event organizers will also provide you with a discount for your readers.
Also use social media, prior to the event, to meet and engage with those who will be attending.
8. Don't Forget to Follow-up
Taking the time to follow-up with attendees is an important part of process of gaining additional speaking and new business opportunities. Providing a personal email to those you collected business cards from and providing a link to your presentation in SlideShare would be helpful tactic to use as a follow-up.
A personal handwritten note would also be a nice follow-up.
9. Enroll in a Speakers Bureau
Many Women Business Leaders have found that enrolling in a speakers bureau has generated a good number of additional speaking opportunities in addition to their blog, writings, interviews and referrals.


text:
As family historians we are constantly searching for evidence of the existence of ancestors. Evidence is not to be confused with information. Evidence is much more than information. It is the information which we analyse and evaluate and which we accept to have authentic relevance to our research.
For the most part in the process of our research, we look for positive evidence. Positive evidence is what every family historian hopes to find. It adds names to our family trees. Positive evidence that an ancestor is associated with our lineage, can only be proved, when our information is tested, and we have sufficiently eliminated all contradictory evidence. As family historians, we seek unequivocal proof that ancestors belong on our family tree. To achieve this end, we use evidence, both positive and negative to reach our conclusions.
|Photo Sharn White © Copyright
|Image Wikimedia Commons
|Ancestors do not always turn up in records... Image Sharn White © Copyright Creative Commons
Negative evidence is defined in Webster's Dictionary as : "evidence of any kind which suggests, via deduction or inference, the non - existence or non presence..."
Elizabeth Shown Mills defines negative evidence as "...an inference one can draw from the absence of information that should exist under given circumstances" [Elizabeth Shown Mills, Evidence Explained, 1st Ed, Electronic. 200, p. 825 & 28.]
Each time a family historian proves kinship with a forebear, the evidence is chronicled and preserved. Be it a record of a birth, baptism, marriage or death, a passenger list or a census record, positive evidence is documented, and our sources are recorded on our family trees. All genealogy programs provide various means by which to cite sources and evidence you have collected. It is also important to document all negative evidence that you discover in your research. It is quite possible that the absence of records of an ancestor, may substantiate your case for relationship. Negative evidence eliminates who is NOT an ancestor and without doubt it proves where your ancestor WAS NOT. Negative evidence does not generate a 'copy' of a record as does positive evidence ( e.g. a baptism record) therefore it may be of benefit to keep a log of all negative evidence you find. Record keeping avoids time wasted re-checking records which you have already investigated.
|Oops already checked this record! Image Sharn White © Copyright
My 2 times great grandfather, John Morrison, mentioned earlier, married Hannah Tait Gair in 1869, in Northumberland, England. On the marriage record, Hannah's father was named as Roger GAIR (occupation -Gardener) and her birth place was stated to be Cramlington, Northumberland. Roger Gair was found easily in the 1861 census where I found Roger aged 46, (born 1815, Alnwick, Northumberland), wife Elizabeth, aged 44 born Cramlington, Northumberland) and daughter Hannah, aged 14 (born in 1846, Cramlington, Northumberland). This Roger Gair was working as the head gardener at Heaton Park. It was not difficult to find a marriage for Roger Gair to Elizabeth TAIT, in Cramlington, in 1840, especially as Hannah's middle name was Tait. A birth for Roger Gair was located in Denwick, Alnwick, Northumberland on October 29, 1815. Any thorough genealogist will attest that a NAME is NOT proof of a person. Despite having a strong argument that this was my family of Gairs, I needed to prove beyond doubt that there was no contradictory evidence. This is where I used Negative Evidence to identify whether the Roger Gair I had found, was the person for whom I was searching.
|Heaton Park where Roger Gair was head gardener. Image Wikimedia Creative Commons
- A search for birth records revealed no other person by the name of Roger Gair born in Northumberland in 1815 or in an expanded search up to 5 years before and after this date.
- No other Roger Gair was born in Alnwick in around 1815.
- No other family with the surname Gair had a father named Roger and a daughter named Hannah in the 1851 and 1861 UK census.
- There were no other later records relating to a Roger Gair born around 1815 (ie death).
- No other Roger Gair could be located whose occupation was that of a gardener.
In the absence of evidence to the contrary, known as Negative Evidence, I arrived at a soundly examined, well supported and reasoned genealogical conclusion that I had found Roger Gair.
So, the next time you spend a day searching in your local archives and go home empty handed, or sit for many hours at your computer only to find no record of an ancestor, think positively of the negative evidence you are gathering. Keep records of all the searches you undertake. Often, it is the absence of evidence that is in itself evidence.


text:
Anger Therapist
Stephanie Burchell, PhD, LMFT, CFLE
Licensed Marriage & Family Therapist
Anger is a healthy and normal emotion; it's how we express our anger that can make it problematic in our relationships. Moreover, anger is considered a secondary emotion. This means, there is a more primary emotion that underlies and fuels our anger. Learning to manage our anger in a more productive, healthy and adaptive fashion will first mean identifying the deeper emotions that often remain outside of our awareness. What might be at the core of your anger....fear? hurt? feelings of helplessness or needing to feel heard by your partner?
Anger Therapist
John Gerson, Ph.D.
Licensed Psychologist
In 10536 - Nearby to Bethel.
Issues with controlling anger have to do with impulse control. This is an issue of development, and suggests that those people who can't control their anger haven't successfully negotiated frustration tolerance early in life. Often, this failure has to do with difficulties that parents themselves had with the issue, as well as parental inadequacies with regard to tenderness and soothing, major ingredients that help establish emotional security and self esteem. I will help you explore the "red zones," the places your brain goes to when life issues trigger you to behave reflexively rather than thoughtfully, and to visualize consequences before taking action. www.ThriveTherapydoc.com
Anger Therapist
Theresa Evans Knight, MA, LMFT, MBA
Licensed Marriage and Family Therapist
In 06851 - Nearby to Bethel.
Anger can present itself when you least expect it. You can be with family and friends at a school or work outing. You can be on a date and your spouse or significant other does something to set you off. I work with individuals and families in identifying those triggers, exploring the origins and the emotional connections and utilizing cognitive behavioral therapy to address the un-healthy and often off-putting interactions.
Anger Therapist
Lenore Millian, Ph. D.
Clinical Psychologist
In 06811 - Nearby to Bethel.
It is important to find the source of the anger, and not merely treat the symptoms. Therefore, I first offer many specific techniques to control that anger. After that, I help the client uncover the sources of the anger that act as triggers. In other words, we take time to delve into the client's psychic order to reach the real reasons for the anger. I help the client understand that knowledge is power and once you better understand yourself, you can eliminate the triggers because you then release their power over you.
Anger Therapist
Ilise Gold, LPC
Licensed Professional Counselor
Erupting and lashing out to relieve your pain creates disruption in your everyday life. While anger is a healthy emotion, lashing out and rage creates guilt and relationship destruction. In my 30+ years of clinical practice, I have provided my clients with a non-judgemental safe environment so together we can build a trust where they can be open and honest without embarrassment or shame. In letting down their defenses and acknowledging their behavior my clients learn how to emotionally regulate their pain by taking ownership and removing themselves from the current situation, which gives them space to provide a more regulated and healthy response.
Anger Therapist
Paula Levy, MA, LMFT
Licensed Marriage & Family Therapist
In 06877 - Nearby to Bethel.
Life can be unfair and we can experience a great deal of anger as a result. Anger can cause us to hurt the ones we love, jeopardize our careers and cause legal and medical issues. The good news is that there are many tools that can help you manage your anger more effectively and to use it more productively. I can help you learn how to control your anger so that you will feel stronger, calmer and in control. Don't let your anger control you. Take control of your life today.
Anger Therapist
Stokes Counseling Services, LPC
Licensed Professional Counselor
In 06770 - Nearby to Bethel.
Anger Management is a focus area for many of our therapists. We help understand where your anger is coming from and how we can help you cope with anger. Many people come to us because others have made comments about their anger or maybe the court system as brought you to seek a counselor. Either way, we can help you cope with your anger in a healthy way. Call us today to schedule your appointment.
Anger Therapist
Juliette Sussmann, LMHC,NCC
New York State Licensed Mental Health Counselor
In 10536 - Nearby to Bethel.
Anger is often triggered by an underlying emotion such as sadness, disappointment but comes out in a way that protects these feelings. Some anger can be healthy; as in being angry enough at a growing waistline to sign up for the gym or speaking up when boundaries get crossed over and over. Through using cognitive behavioral therapy and mindfulness techniques, clients can learn to communicate in ways that meet their needs and still respect the needs of others.
Anger Therapist
Wendy Eisenberg, Ph.D.
Licensed Psychologist
In 06883 - Nearby to Bethel.
I know a secret about people that are angry. They are also people that are hurting. They are in pain and they never learned how to express their anger in a productive way. That is where I come in. I teach you step by step how to get rid of old patterns that are damaging your relationships at home and perhaps at work. You are not a bad person. You are just a person who is hurting and never learned how to express anger in a grown-up way. I will teach you how to tame your "anger beast" so that you can get on with your life. I like to think of myself as an expert at this! I have helped a lot of people with their anger problems. Lets get started.
Anger Therapist
Connecticut Online Counseling, CT Licensed Therapists
Licensed Professional Counselor
In 06770 - Nearby to Bethel.
Anger Management can be a difficult thing to overcome. The first objective is to uncover where this is coming from and how you can build up the skillset to work through these feelings so you can communicate what is going on effectively. Most times people with anger issues, are impacted at home, work, school, friends, relationships, etc. You do not need to do this alone and we can get you. Contact us to get started today.
Anger Therapist
Linda Palmieri, MFT
prelicensed Marriage and Family Therapist
In 06468 - Nearby to Bethel.
Together we will look at where the anger is truly coming from. We will look at past family patterns that may have handed this down to you. We will look at your current situation and see perhaps who you are really angry at. Sometimes it is not who or what you think. We will work on tactics to release your angry in a healthy manner and see what is under the anger.
Anger Therapist
Margaret Burton, MS, LPC, NCC
Licenced Professional Counselor
In 06461 - Nearby to Bethel.
Does your anger seem out of control? Is it causing you to regret your actions or the hurt you caused to those around you? Anger is a normal and powerful emotion that everyone experiences. Learning how to express this emotion can be challenging, even when it is justified. However, identifying factors that trigger your anger is an important step in finding the balance and learning how to control your reactions. Together we can develop strategies specific to your triggers and help you find tools which in turn will help you to live a more healthy and productive life.
Anger Therapist
Kelley Hopkins-Alvarez, LPC,NCC,BCC,MS,MSEd
Licensed Professional Counselor & Board Certified Coach
In 06877 - Nearby to Bethel.
Has someone told you that you are getting way too stressed out about things?I will help you learn to communicate your thoughts without becoming confrontational. Do you even know what your positive traits are anymore? We'll discuss them and also that anger is more of a secondary emotion to more primary feelings such as fear, guilt, shame, powerlessness, or sadness. Together, we will identify the triggers that upset you, so that you can be more self-aware and develop coping skills. Reducing anger will improve your self-image, patience, interactions with family and career success, while reducing health issues such as headache and backaches. I DO NOT DO Court Mandated Anger Management
Anger Therapist
Joyce Colburn, LCSW
Licensed Clinical Social Worker
My approach to anger management begins with listening and assessing to determine the stressors that trigger the client's anger. I may recommend medication (administered under the supervision of a medical professional). I then tailor a treatment plan to each client using a variety of modalities (including family therapy, cognitive behavioral therapy, and solution-oriented therapy) to help them learn how to manage their feelings and avoid the consequences of unmanaged anger.
Anger Therapist
Randy Carrin, Psy.D.
Licensed Clinical Psychologist
In 06708 - Nearby to Bethel.
Anger management counseling can help to identify stressors and learn the steps to stay calm in the face of anger. The goal is to handle tense situations in more constructive and positive ways by reducing the emotional and physical arousal that anger can cause. It will provide the tools to take back your life and resolve the triggers that result in unplanned anger reactions.
Anger Therapist
Alice Kroll, LPC,NCC
LICENSED PROFESSIONAL COUNSELOR,National Certified
In 06478 - Nearby to Bethel.
In my practice I help clients explore, in a safe environment, the source of their anger. I supply various tools to help when anger emerges that allow alternative strategies to deal with every day life stresses and people. Having tools promotes healthy personal relationships and a happier more satisfying, sucessful life. Venues such as spirituality, meditation, writing and continuing with counseling when needed. This is a safe place for compassion and understanding.
Anger Therapist
Kevin Fleming Ph.D.
Coach/Change Agent/Consultant
In 06883 - Nearby to Bethel.
Grey Matters International and the work of Kevin J. Fleming, Ph.D approaches issues of anger management in a very humane yet fresh perspective. You see, anger is a normal emotion but it is the valence (intensity) as well as the coupling choice of what one does with this that is the problem. Telling someone to "not" do it or modifying behavior with a trite psychological plan that only breeds a compliant response is not the way to change anger. Brainwave optimization is a new cutting edge technology that allows one to rewire circuitry responsible for reactivity driving the anger. Contact Grey Matters International, Inc now at firstname.lastname@example.com or 877-606-6161.
You have Found the Best Anger Management Therapists in Bethel, CT.
Thank you for visiting our Connecticut page of anger counselors in Bethel, Connecticut who are experienced in therapy and treatment for anger issues. Ask your provider about classes or workshops in addition to individual sessions to help with issues relating to anger. Begin your new journey today.
Bethel is located in Fairfield County, Connecticut. It has a land area of 16.88 square miles and a water area of 0.03 square miles.  The population of Bethel is 19,529 people with 7,211 households and a median annual income of $92,125. .
Therapy Affordability Meter for Bethel, CT
Very Affordable
Booking a weekly counseling session with a licensed therapist in Bethel is not a large financial issue for the majority of people in this area. Sustaining a commitment to mental health treatment is easily accessible for the average family, but ask your therapist if there are any concerns as many will accept insurance or even offer sliding scale fees. Low cost counseling and affordable therapy are also sometimes offered by listed city and university level clinics, check with your local Bethel public health department.


text:
Flyin' Feathers
Are you looking to stay trendy?
Fanny Packs are exploding in popularity - don't get left behind.
Use #lilPACKS for a chance to be featured on our Instagram @lilpacksofficial.
lilPACKS offers a 30 Day Refund Policy. Please contact us at firstname.lastname@example.com.
Worldwide delivery is guaranteed within 4 weeks.


text:
Roof rails and high-class surfaces for your car
We are a full-service design, development and system integration supplier for roof rails and other decorative structural trim. Our global team works with carmakers across the world.
From exterior trim to roof rail solutions
We deliver aluminum components that meet the highest demands for corrosion resistance and finish. Our range includes specialized coatings that we developed to meet the problem of damage from the aggressive alkali chemicals being used more frequently in high-pressure car cleaning.
Why anodizing helps
Anodizing your aluminum extrusions creates a dirt-repellent surface and improves corrosion resistance. It provides a surface with electrically insulated coating and preserves the finish of the metal. And it creates a surface that is pleasant to touch.
High-end aluminum exterior components
Extruded aluminum roof rails are growing more popular. These are fastened on top of the vehicle and used to carry additional luggage and equipment. We use aluminum extrusions because they enable attractive, low weight and high-strength designs.
Other common exterior trim items that are manufactured with aluminum include:
- Radiator grills
- Window frames
- Light rings
- Door handles
- Emblems
- Antennas
- Sun roof frames and components
Hydro can take on the entire assignment, from development and design to manufacturing, surface treatment, assembly, packaging and distribution.


text:
Office Spaces for Rent in the Humber Heights Area
Make a Quick Enquiry or Add to List, then click SHORTLIST in top right hand corner.
Toronto Street, Toronto, M5C
Our ref: # 17985
This business centre provides you with professional, full service executive packaged office space rentals and solutions, with flexible lease terms to suit your business. Located in a hist...
From $499
per person / month
Bloor Street, Toronto, M8X
Our ref: # 15500
Located in an important business and commercial district, the Sun Life Bloor business centre is on the sixth floor of an awarding-winning, 17-story tower that's part of a landmark office com...
call us
for pricing
Bloor Street West, Toronto, M8X
Our ref: # 12310
High profile executive suites available in an AAA high rise tower, in one of the world's largest financial capitals. We have a full range of office sizes available for long or short-term...
From $500
per person / month
Four Seasons Place, Toronto, M9B
Our ref: # 12972
Etobicoke is a prestigious area located on the western fringe of Toronto, and is the cushion between Toronto and Mississauga. Easily accessible by public transportation (bus) and is 5 minute...
From $500
per person / month
Skymark Avenue, Mississauga, L4W
Our ref: # 18158
An impressive business center comprises serviced offices in Ontario, situated within a popular business park and offering an ideal location for any company. The building was designed by an i...
From $500.00
per person / month
Airport Road, Mississauga, L4V
Our ref: # 3590
The Centre is located at the main entrance to the Toronto International Airport. The Centre complex houses a variety of internationally based corporations who have taken advantage of unrival...
From $800
per person / month
Matheson Blvd East, Mississauga, L4W
Our ref: # 7606
Two excellent locations in Mississauga for all of your Virtual Office Needs. One on Matheson Blvd minutes to Pearson International Airport and the other on City Centre Dr between City Hall a...
From $600
per person / month
Matheson Boulevard East, Mississauga, L4W
Our ref: # 16435
The Toronto Airport Corporate business centre boasts several strategic advantages for any business including a business park location minutes away from the Toronto Pearson International Airp...
call us
for pricing


text:
Read latest COVID-19 advice for parents and childcarers here
Start by entering your postcode to set up your FREE
account and read reviews about childcarers local to you.
You can then book childcare online – just select the
date, time and address for your booking.
Choose the local carers you'd prefer us to offer your bookings
to first and we'll keep you updated of progress by email.
Your childcarer will call you before the booking and you should pay
her for her time at the end. Rates start from just £8.75.
Pay nothing until after you have used Sitters - guaranteed. A booking
fee (£4-£6) and quarterly membership fee (£14.95) will only be
charged to your credit card after your booking has taken place.
Read reviews of approved Sitters local to you
My first ever babysitter to watch my children since we moved here to Scotland. Shazia was truly amazing. She was a very last minute booking. I was in such a rush and she was so understanding. The children could not stop talking about her, begging for her to come and babysit every time. My son was ecstatic about her knowledge of Xbox giving her 2 thumbs up for "Coolness". My daughter sang her praises. They made jewellery together, the highlight of my daughter's day. Anyway, I can go on about her positives all day... We are all looking forward to booking her again.
Frances was lovely, warm and bubbly. The children were beaming with delight when I returned home. She had a bag of activities that even my son, who is an computer gaming fanatic couldn't, resist and joined in with his little sister. I would definitely recommend Frances and book her again.
I would highly recommend Alison and would love her to look after my kids again. I was a little nervous about having someone i didn't know look after my kids but I felt comfortable straight away with Alison and she was great with the kids. She was also great with my pets x.


text:
I spoke to Richard yesterday (Jan 23rd) and he says things are progressing nicely.
Now, for the self-serving part of this post.
He has four committed orders. If he has ten by Feb 15, we ten will get a bigger discount because he has economies in his production run.
John Bowen and I need at least six more of you to ante up quickly with deposits. Who knows what would happen if a hundred of you did!
That's why Richard has been mum on the amount of the discount - it will vary with the number of orders.
Richard even darkly hinted that he may need to raise the price after Feb. 15 if the initial order quantity is small. Don't procrastinate if you're interested in a finely-made, American-crafted camera with an innovative design and light weight.
I'm ordering the 4x5 and 5x7 backs, too. It will all replace my existing Sinar and Wista with MUCH less weight and bulk.
So this time, my financial interest has to do with the size of the check I write Richard. With your help, it will be smaller for all of us, and Richard will be well-launched into the camera business (deservedly so).


text:
Message Board
James Luceno Message Board
Talk about the novels, new and used books that Luceno has written!
Author Luceno's Book Reviews
Memories End - Web Warriors 1
Tech and Marz are two teenage orphans living in New York City in the not-so-distant future. In a world of sophisticated virtual reality, Tech and Marz are expert hackers, chasing down information that's gone missing on the network. But on a routine run, they encounter trouble in the form of a creature they've never seen before, leaving them determined to find out the truth - a truth buried in a sophisticated computer system....
Star Wars: Labyrinth of Evil
Del Rey, Feb 2005, 25.95, 339 pp. ISBN 0345475720 Peace is broken by the Separatists who want to leave the Republic and join the opposition. The Jedi Knights fight for the Republic but nobody in the senate is prepared to believe that the enemy has infiltrated that august body but many of its prominent members are allied with the Sith Darth Sidious. His allies, former Jedi Knight Count Dooku and cyborg killing machine General Grievous are being ...
Star Wars: The New Jedi Order: Unifying Force
Del Rey, Nov 2003, 26.95, 464 pp. ISBN: 0345428528 The Galactic Alliance reels under the assault of the Yuuzhan Vong horde. Even when an important moral boost occurs by temporarily slowing the advance, the enemy fails to blink as they continue their unstoppable assault. The vanquishers subjugate world after world as they defeat the Jedi and its allies stepping closer to dictatorial galaxy ascendancy. Coruscant falls in a crushing defeat with...


text:
Sign In as
Hard Drives
Solid State Drives
Get your digital life back. We offer options to recover files from any drive brand and storage device.
Let the experts recover your files if there is physical damage to your storage device.
Get help from the storage experts.
95% customer satisfaction rating.
No hidden fees, and you pay only when your data can be recovered.
We support any file type, drive brand or storage medium.
Around the clock access to case status tracking
Download your recovered data from the cloud (where applicable).
"You've taken me from a state of panic and devastation to a state of rejoice"
"We're a small documentary production company, and the outright loss of these files would have been catastrophic for us"
"They have now returned all of our data – over 7.5 million files – and as far as we can tell, every bit of it is a good as new!"
"The knowledge of losing 3/4th of your children's 'lives' in pictures was way too much to bear-the loss was like someone you loved just died!"
"The data you helped us to recover represented many years of video projects, presentations and very important files from various productions"
If it stores data, we can recover files from it.
Desktop Computers
External Hard Drives


text:
People who are new to e-mail marketing often don't realize that not every sent e-mail reaches their recipients. Many reasons can compromise e-mail deliverability.
Let's try to identify the main reasons:
Technical reasons
Your subscriber's e-mail address is not correct. Your subscriber might have made a typing error when subscribing to your newsletter. Even a simple or silly error in typing the correct e-mail address invalids it.
Remember that a few people forget their correct e-mail address, and give you a incorrect one.
The recipient's mailbox is full. It's not unusual that some people don't delete their old messages in their mailbox. Some mailboxes have a limited storage space. When the mailbox is full, all the new messages are rejected.
The e-mail address no longer exists. It happens when old or unused mailboxes get deleted
Network related problems. Sometimes they can occur when an ISP runs server maintenance or something goes wrong with the network.
When e-mails don't reach their recipients and consequently they are returned to the sender, a so-called "bounce" is generated.
A "hard bounce" occurs when the error is permanent (i.e. when the e-mail address no longer exists).
"Soft bounces" are related to temporary errors (i.e. when a recipient isn't reachable due to a network failure, the system tries to deliver the message again).
See SendBlaster's bounce-backs management
Anti spam filters
Another big problem in delivering your e-mail marketing campaigns is represented by spam filters.
Even when you're not spamming, sometimes your e-mail can be considered as spam all the same. So, it gets deleted or moved into the spam folder of the recipient's e-mail reader.


text:
Most Popular
A-Z Sports
W71 Premium Hoody
W73 Premium Contrast Hoody
W71K Premium Kids Hoody
W73K Premium Kids Hoody
AWDis College Hoodie
Gildan Heavy Blend Hooded Sweatshirt
Fruit of the Loom Classic Hooded Sweatshirt
Jerzees Hooded Sweatshirt
AWDis Varsity Hoody
AWDis Zoodie
Gildan Heavy Blend Zip Hooded Sweatshirt
Fruit of the Loom Classic Zip Hooded Sweatshirt
AWDis Varsity Zoodie
AWDis Girlie Zoodie
Fruit of the Loom Premium Lady Fit Zip Hooded Jacket
AWDis Kids Hoodie
Gildan Kids Heavy Blend Hooded Sweatshirt
Fruit of the Loom Kids Classic Hooded Sweatshirt
Jerzees Schoolgear Kids Hooded Sweatshirt
AWDis Kids Varsity Hoodie
AWDis Kids Zoodie
Gildan Kids Heavy Blend Zip Hooded Sweatshirt
Fruit of the Loom Kids Classic Zip Hooded Sweatshirt
AWDis Kids Varsity Zoodie
From: £18.95 (£22.74 inc VAT)
Material: 80% cotton/20% polyester.Double fabric hood with contrast inner and contrast flat lace drawcord.Front kangaroo pouch pocket with opening for ear phone cord.Hidden ear phone loops.Ribbed cuffs and hem.Twin needle stitching.WRAP Certified Production.Weight: 280 gsm
Enter your name, email and the issue you are experiencing below, and then click 'Submit'. A snapshot of the design you have created so far will automatically be sent to us.A live chat window will then open where we can help you as we would have received your design.
Select your image(s) you wish to use below, then click 'Use Selected Image(s)'
No Images in Library - Please sign in or click 'Browse'.


text:
In El Shaddai: Ascension of the Metatron you are guided by a pre-fall Lucifer who carries a cell phone with God on his speed dial.
Inspired by the Old Testament's Book of Enoch, you star as Enoch himself, a human called to heaven in order to help God round up seven fallen angels in order to prevent the flood that would wipe out mankind.
The result was an oddly beautiful, and unique game. And it looks like there is going to be more of it.
A teaser website launched, with the tagline: "Who is the greatest angel according to God?" The website reads "El Shaddai new project website is open" under the section marked "update".
So look forward to El Shaddai resurrecting itself sometime in the future!
エルシャダイ新プロジェクトプレサイトオープン! [El Shaddai via Kotaku Japan]


text:
IBM Tucson Executive Briefing Center is Hiring!
Visits (13443)
With the economy recovering from the [Global Recession], my manager has been given authorization to hire new Subject Matter Experts (SMEs) for the [IBM Tucson Executive Briefing Center!] Here are a few answers to questions you might have:
Where is the job located?
The job is located in Tucson, Arizona, which is a great place to live! Tucson is the headquarters for IBM storage design and development, with the largest collection of engineers, software developers and testers. The IBM Tucson Executive Briefing Center is located on the [University of Arizona Science and Technology Park] campus that houses over 7,000 employees from 50 different companies.
What does the job entail?
Primarily, you will be developing, customizing and presenting Powerpoint presentations and live product demos. For some briefings, you will work with sales reps, IBM Business Partners, and clients to develop an agenda of topics to discuss. At times, the presentation may involve working to solve the client's problems, drawing on the whiteboard or flip charts to help capture the requirements and architect a solution.
Which products are we talking about?
The [IBM System Storage product line] includes solid-state drives (SSD), block and file-based disk systems, tape drives and libraries, storage virtualization, and storage management software.
Is there any opportunity for travel?
Most of the presentations will be performed in Tucson, either in person, by webcast or video conference call. Sometimes, this includes discussions over drinks, dinner or golfing. Occasionally, there will be travel to present at client locations, IBM branch offices, events or conferences. My manager estimates approximately 10 percent travel.
Is the pay based on a commission?
Absolutely not! We are consultants, not salespeople. To maintain our "trusted advisor" status, it is a flat salary, with possibility for year-end bonus based on how well our division does overall. This allows us to present and position all of the products fairly to the clients at briefings without bias. Our clients appreciate that! The job is considered pre-sales technical support.
Is training included?
Yes. Assuming you already have a strong background in storage hardware and software, and how these connect to SAN and LAN networks for a variety of operating systems like z/OS, AIX, Windows and Linux, there will be training for the latest updates and features of the IBM products throughout the year. Also, there will be professional training to build up your public speaking and meeting facilitation skills.
How do I apply?
If you are an American citizen, fluent in the English language, and have at least a Bachelor's Degree, go to the [IBM Employment website], look for "Storage Support Specialist" position using job code "STG-0524037" or "STG-0525309". IBM is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, or veteran status.
The job is immediately available. Apply today!
technorati tags: IBM, Tucson, EBC, SME, Arizona


text:
Find everything you need to track your success on the road.
Manage your payment options, review trip history, and more.
You're seeing information for Washington D.C.. To see local features and services for another location, select a different city.
Our mission is to bring safe, reliable self-driving transportation to everyone, everywhere.
We start with a vehicle known for its strong safety track record. Our team then modifies the vehicle to integrate the sensors and software needed for our self-driving system.
Uber's vision for self-driving technology is built on a foundational commitment to safety.
We're leading the industry with cutting-edge research for self-driving cars in broad areas of computer vision, machine learning, and robotics.
We want to bring self-driving vehicles to the Uber network around the world. Today, we are focused on the safe development of safe self-driving technology, starting with a number of cities in the US and Canada.
Our self-driving strategy is powered by partnership. By combining Uber's self-driving technology with partners' state-of-the-art vehicles, sensors, and safety technology, we'll get to the future faster.
For updates on our technology, where we're operating, and plans for the future, head to our blog on Medium to find out more.
At ATG, we pride ourselves on the amazing team we've built. We're looking for world-class researchers, engineers, and product specialists who prioritize safety and want to join our mission to bring safe, reliable self-driving transportation to everyone, everywhere.


text:
I don't shop for nice clothing very often and I usually don't shop for clothing at Anthropologie because of the prices for those threads and also because most of their clothing doesn't fit me very well. I have curves so I'm more of Ann Taylor Loft gal.
But last week I found myself pulled by in by the tractor beam that exists within 50 feet of any Anthropologie store, it sucks you in uncontrollably and you must, arms flailing, surrender to the vortex of inspiration. Once inside, you must channel your Jedi mind powers of self control to pull yourself out of an Anthropologie store without spending a dime. Unfortunately, last Thursday, I had no such self control.
So now I have to tell you about my new Anthropologie sweater. I have a hard time spending $48 dollars on a sweater, let alone One Hundred and Forty Eight Dollars on a sweater because I don't think I've ever spent that amount of money on any non-coat or dress piece of clothing in my life, but Oh Em Gee I am in love. I have justified this purchase by the fact that I wear it everyday and will continue to wear it everyday between hand washings through April which means I really am only paying two dollars a day which is less than a Starbucks! I'm saving money! I'm saving money!
Which reminds me of when my mom would go shopping with her limited budget and buy something cute for herself, and she would come home and tell my dad that she "saved money" because she bought it on sale and he would say "no you didn't, you spent money" and she would say "no, I saved money" and he would wink and say "no you spent money" and they would go back and forth, back and forth until she walked out of the room with her cute new thing. But that analogy really doesn't apply here because I didn't buy my sweater on sale so I don't really know why I brought that up.
I was in Anthropologie and spied this Cavendish sweater and loved it at first sight. This sweater designed by Rosie Nierra is grey blue and oat with subtle golden metallic threads. What? Grey blue and oat with subtle golden metallic threads? Seriously? It's like Rosie knit my house into a sweater. It's like she read my blog and knit my house into a sweater.
Then I was all, "Oh I'll just try it on" knowing full well the price tag read One Hundred and Forty Eight Dollars and that's when you know you're in trouble because if it doesn't fit right then okay, but if it does, you will stand there in the dressing room for ten minutes turning back and forth, admiring your cute new find and justifying the expense because you love it so much. You're all nodding your heads right now, I know it.
I could live in this sweater. Actually, truth. I have been living in this sweater. It owns me completely. Just look at it. LOOK at it! All fitted around the top but then all swishy and ungrabby around the mid section…
I asked my husband what he thought of my new sweater and he got that crinkled nose and said "It's okay, looks a little frumpy" and I audibly gasped. How dare he diss THE sweater. This was minutes before Coco the kitten decided to climb up my back when I was wearing said beloved sweater and I almost had a heart attack not because of her claws which hurt but because I gasped that she might possibly with her kitten claws snag a knitted yarn from my precious sweater and the scratches I can take, the loose threads I cannot. Within a five minute period, a conspiracy was formed to ruin my grey blue, oat, and subtle golden thread swishy sweater. I fear for its safety.
I also bought this navy Scalloped Strings Tank for Sixty Eight Dollars because its white braided detail on the top called me by my full legal name from across the store.
It looks so cute on, and will be just adorable with white capris this summer for that day we go boating on the bay… you know, with all our yacht club friends. Actually, I need some of those yacht club friends, so if you know any yacht club friends in the Bay Area, please tell them my number is 800-LV2-SAIL.
So I walked out of Anthropologie having spent $216 on two things. Two things! And carrying one shopping bag that weighed as much as a few ounces of feathers. It felt so wrong, but wearing this sweater going on four days now feels oh so right. Antropologie, I love you, but I really hate you too.
Thoughts for today. Have you been caught in the Anthropologie tractor beam and how did you escape? Why do all their clothing prices end in 8 and not 9? Why do people always say "Less than a Starbucks a day!" when they try to sell you something? Please discuss.


text:
How to say cache in Icelandic?
Would you like to know how to translate cache to Icelandic? This page provides all possible translations of the word cache in the Icelandic language.
- skyndiminniIcelandic
Discuss this cache English translation with the community:
Use the citation below to add this definition to your bibliography:
"cache." Definitions.net. STANDS4 LLC, 2020. Web. 5 Apr. 2020. <https://www.definitions.net/translate/cache/EN>.


text:
ADC3 click carries Microchip's MCP3428 16-bit multichannel analog-to-digital converter. The board has four pairs of screw terminals that five you access to the chip's four differential input channels. It can be configured in different ways depending on whether accuracy or speed is your main concern.
At the highest resolution of 16 bits, the chip produces conversion results at 15 samples per second. At 14 bits, the rate is 60 samples per second. Maximum conversion speed is achieved in 12-bit mode: 240 samples per second.
ADC3 click communicates with your target MCU through mikroBUS I2C pins (SCL, SDA). A pair of on-board SMD jumpers allow switching between different I2C addresses (in positions 0,0 by default). Another SMD jumper allows you to configure it for 3.3V or 5V power (in 3.3V position by default).
Note: The picture shows the board with through-hole headers. The board now comes populated with male pin headers already soldered for your convenience. The board's user manual has yet to be updated to remove the soldering instructions.
You also can connect Click boards to many other popular platforms via these adapters:
In addition, it is royalty-free to add mikroBUS to your own designs. Visit the mikroBUS Category to see the full line of Click boards.


text:
The Cornerstone
I am an engaged learner in constant search of knowledge.
I foster human dignity through acts of civility and respect.
I maintain a distinguished character based on truth, honesty, and integrity.
I pursue inner-peace by recognizing the significance of spirituality.
I demonstrate honorable citizenship through acts of civic engagement.
I embrace community by active involvement and service.
I lead a lifestyle that advances physical health and emotional well-being.
"You're a Seahawk Wherever You Go"