text:
Community driven support forum for F@H
| F@h Links:
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• The Software
F@h Servers: • Project Summary • Server Status
F@h Stats: • Official • Extreme OC Other: • Tools
Moderators: Site Moderators, PandeGroup
*********************** Log Started 2014-03-07T23:27:10Z ***********************
23:27:10:************************* Folding@home Client *************************
23:27:10: Website: http://folding.stanford.edu/
23:27:10: Copyright: (c) 2009-2014 Stanford University
23:27:10: Author: Joseph Coffland <firstname.lastname@example.com>
23:27:10: Args: --open-web-control
23:27:10: Config: C:/Users/Anonymous/AppData/Roaming/FAHClient/config.xml
23:27:10:******************************** Build ********************************
23:27:10: Version: 7.4.4
23:27:10: Date: Mar 4 2014
23:27:10: Time: 20:26:54
23:27:10: SVN Rev: 4130
23:27:10: Branch: fah/trunk/client
23:27:10: Compiler: Intel(R) C++ MSVC 1500 mode 1200
23:27:10: Options: /TP /nologo /EHa /Qdiag-disable:4297,4103,1786,279 /Ox -arch:SSE
23:27:10: /QaxSSE2,SSE3,SSSE3,SSE4.1,SSE4.2 /Qopenmp /Qrestrict /MT /Qmkl
23:27:10: Platform: win32 XP
23:27:10: Bits: 32
23:27:10: Mode: Release
23:27:10:******************************* System ********************************
23:27:10: CPU: Intel(R) Core(TM) i7 CPU 860 @ 2.80GHz
23:27:10: CPU ID: GenuineIntel Family 6 Model 30 Stepping 5
23:27:10: CPUs: 8
23:27:10: Memory: 4.00GiB
23:27:10: Free Memory: 2.84GiB
23:27:10: Threads: WINDOWS_THREADS
23:27:10: OS Version: 6.1
23:27:10: Has Battery: false
23:27:10: On Battery: false
23:27:10: UTC Offset: 4
23:27:10: CWD: C:/Users/Anonymous/AppData/Roaming/FAHClient
23:27:10: OS: Windows 7 Ultimate
23:27:10: OS Arch: AMD64
23:27:10: GPUs: 0
23:27:10: CUDA: Not detected
23:27:10:Win32 Service: false
23:27:10: <!-- Folding Slots -->
23:27:10: <slot id='0' type='CPU'/>
23:27:10:Trying to access database...
23:27:10:Successfully acquired database lock
23:27:10:Enabled folding slot 00: READY cpu:7
23:27:10:WU00:FS00:Running FahCore: "C:\Program Files (x86)\FAHClient/FAHCoreWrapper.exe" C:/Users/Anonymous/AppData/Roaming/FAHClient/cores/www.stanford.edu/~pande/Win32/AMD64/Core_a4.fah/FahCore_a4.exe -dir 00 -suffix 01 -version 704 -lifeline 980 -checkpoint 15 -np 7
23:27:10:WU00:FS00:Started FahCore on PID 4032
23:27:10:WU00:FS00:Core PID:1000
23:27:10:WU00:FS00:FahCore 0xa4 started
23:27:11:WU00:FS00:0xa4:Folding@Home Gromacs GB Core
23:27:11:WU00:FS00:0xa4:Version 2.27 (Dec. 15, 2010)
23:27:11:WU00:FS00:0xa4:Preparing to commence simulation
23:27:11:WU00:FS00:0xa4:- Looking at optimizations...
23:27:11:WU00:FS00:0xa4:- Files status OK
23:27:11:WU00:FS00:0xa4:- Expanded 546568 -> 843608 (decompressed 154.3 percent)
23:27:11:WU00:FS00:0xa4:Called DecompressByteArray: compressed_data_size=546568 data_size=843608, decompressed_data_size=843608 diff=0
23:27:11:WU00:FS00:0xa4:- Digital signature verified
23:27:11:WU00:FS00:0xa4:Project: 7646 (Run 6, Clone 3, Gen 134)
23:27:11:WU00:FS00:0xa4:Assembly optimizations on if available.
23:27:11:WU00:FS00:0xa4:Entering M.D.
23:27:14:12:127.0.0.1:New Web connection
23:27:16:WU00:FS00:0xa4:Mapping NT from 7 to 7
23:27:17:WU00:FS00:0xa4:Completed 0 out of 2500000 steps (0%)
23:47:12:WU00:FS00:0xa4:Completed 25000 out of 2500000 steps (1%)
*********************** Log Started 2014-03-07T22:52:37Z ***********************
22:52:37:************************* Folding@home Client *************************
22:52:37: Website: http://folding.stanford.edu/
22:52:37: Copyright: (c) 2009-2014 Stanford University
22:52:37: Author: Joseph Coffland <email@example.com>
22:52:37: Args: --open-web-control
22:52:37: Config: C:/Users/Anonymous/AppData/Roaming/FAHClient/config.xml
22:52:37:******************************** Build ********************************
22:52:37: Version: 7.4.4
22:52:37: Date: Mar 4 2014
22:52:37: Time: 20:26:54
22:52:37: SVN Rev: 4130
22:52:37: Branch: fah/trunk/client
22:52:37: Compiler: Intel(R) C++ MSVC 1500 mode 1200
22:52:37: Options: /TP /nologo /EHa /Qdiag-disable:4297,4103,1786,279 /Ox -arch:SSE
22:52:37: /QaxSSE2,SSE3,SSSE3,SSE4.1,SSE4.2 /Qopenmp /Qrestrict /MT /Qmkl
22:52:37: Platform: win32 XP
22:52:37: Bits: 32
22:52:37: Mode: Release
22:52:37:******************************* System ********************************
22:52:37: CPU: Intel(R) Core(TM) i7 CPU 860 @ 2.80GHz
22:52:37: CPU ID: GenuineIntel Family 6 Model 30 Stepping 5
22:52:37: CPUs: 8
22:52:37: Memory: 4.00GiB
22:52:37: Free Memory: 3.27GiB
22:52:37: Threads: WINDOWS_THREADS
22:52:37: OS Version: 6.2
22:52:37: Has Battery: false
22:52:37: On Battery: false
22:52:37: UTC Offset: 4
22:52:37: CWD: C:/Users/Anonymous/AppData/Roaming/FAHClient
22:52:37: OS: Windows 8 Pro
22:52:37: OS Arch: AMD64
22:52:37: GPUs: 0
22:52:37: CUDA: Not detected
22:52:37:Win32 Service: false
22:52:37: <!-- Folding Slots -->
22:52:37: <slot id='0' type='CPU'/>
22:52:37:Trying to access database...
22:52:37:Successfully acquired database lock
22:52:37:Enabled folding slot 00: READY cpu:7
22:52:37:WU00:FS00:Running FahCore: "C:\Program Files (x86)\FAHClient/FAHCoreWrapper.exe" C:/Users/Anonymous/AppData/Roaming/FAHClient/cores/www.stanford.edu/~pande/Win32/AMD64/Core_a3.fah/FahCore_a3.exe -dir 00 -suffix 01 -version 704 -lifeline 3148 -checkpoint 15 -np 7
22:52:37:WU00:FS00:Started FahCore on PID 3436
22:52:37:WU00:FS00:Core PID:4000
22:52:37:WU00:FS00:FahCore 0xa3 started
22:52:38:WU00:FS00:0xa3:Folding@Home Gromacs SMP Core
22:52:38:WU00:FS00:0xa3:Version 2.27 (Dec. 15, 2010)
22:52:38:WU00:FS00:0xa3:Preparing to commence simulation
22:52:38:WU00:FS00:0xa3:- Looking at optimizations...
22:52:38:WU00:FS00:0xa3:- Files status OK
22:52:38:WU00:FS00:0xa3:- Expanded 3850137 -> 4392432 (decompressed 114.0 percent)
22:52:38:WU00:FS00:0xa3:Called DecompressByteArray: compressed_data_size=3850137 data_size=4392432, decompressed_data_size=4392432 diff=0
22:52:38:WU00:FS00:0xa3:- Digital signature verified
22:52:38:WU00:FS00:0xa3:Project: 8581 (Run 0, Clone 5, Gen 444)
22:52:38:WU00:FS00:0xa3:Assembly optimizations on if available.
22:52:38:WU00:FS00:0xa3:Entering M.D.
22:52:40:11:127.0.0.1:New Web connection
22:52:44:WU00:FS00:0xa3:Mapping NT from 7 to 7
22:52:44:WU00:FS00:0xa3:Completed 0 out of 500000 steps (0%)
23:05:48:WU00:FS00:0xa3:Completed 5000 out of 500000 steps (1%)
23:17:47:WU00:FS00:0xa3:Completed 10000 out of 500000 steps (2%)
*********************** Log Started 2014-03-08T00:14:54Z ***********************
00:14:54:************************* Folding@home Client *************************
00:14:54: Website: http://folding.stanford.edu/
00:14:54: Copyright: (c) 2009-2014 Stanford University
00:14:54: Author: Joseph Coffland <firstname.lastname@example.com>
00:14:54: Args: --child --lifeline 1698 /etc/fahclient/config.xml --run-as
00:14:54: fahclient --pid-file=/var/run/fahclient.pid --daemon
00:14:54: Config: /etc/fahclient/config.xml
00:14:54:******************************** Build ********************************
00:14:54: Version: 7.4.4
00:14:54: Date: Mar 4 2014
00:14:54: Time: 12:02:38
00:14:54: SVN Rev: 4130
00:14:54: Branch: fah/trunk/client
00:14:54: Compiler: GNU 4.4.7
00:14:54: Options: -std=gnu++98 -O3 -funroll-loops -mfpmath=sse -ffast-math
00:14:54: -fno-unsafe-math-optimizations -msse2
00:14:54: Platform: linux2 3.2.0-1-amd64
00:14:54: Bits: 64
00:14:54: Mode: Release
00:14:54:******************************* System ********************************
00:14:54: CPU: Intel(R) Core(TM) i7 CPU 860 @ 2.80GHz
00:14:54: CPU ID: GenuineIntel Family 6 Model 30 Stepping 5
00:14:54: CPUs: 8
00:14:54: Memory: 3.85GiB
00:14:54:Free Memory: 3.44GiB
00:14:54: Threads: POSIX_THREADS
00:14:54: OS Version: 3.8
00:14:54:Has Battery: false
00:14:54: On Battery: false
00:14:54: UTC Offset: 0
00:14:54: CWD: /var/lib/fahclient
00:14:54: OS: Linux 3.8.0-36-generic x86_64
00:14:54: OS Arch: AMD64
00:14:54: GPUs: 0
00:14:54: CUDA: Not detected
00:14:54: <!-- Client Control -->
00:14:54: <fold-anon v='true'/>
00:14:54: <!-- Folding Slot Configuration -->
00:14:54: <gpu v='false'/>
00:14:54: <!-- Folding Slots -->
00:14:54: <slot id='0' type='CPU'/>
00:14:54:Switching to user fahclient
00:14:54:Trying to access database...
00:14:55:Successfully acquired database lock
00:14:55:Enabled folding slot 00: READY cpu:7
00:14:55:WU00:FS00:Running FahCore: /usr/bin/FAHCoreWrapper /var/lib/fahclient/cores/www.stanford.edu/~pande/Linux/AMD64/Core_a3.fah/FahCore_a3 -dir 00 -suffix 01 -version 704 -lifeline 1700 -checkpoint 15 -np 7
00:14:55:WU00:FS00:Started FahCore on PID 1923
00:14:55:WU00:FS00:Core PID:2016
00:14:55:WU00:FS00:FahCore 0xa3 started
00:14:56:WU00:FS00:0xa3:Folding@Home Gromacs SMP Core
00:14:56:WU00:FS00:0xa3:Version 2.27 (Dec. 15, 2010)
00:14:56:WU00:FS00:0xa3:Preparing to commence simulation
00:14:56:WU00:FS00:0xa3:- Looking at optimizations...
00:14:56:WU00:FS00:0xa3:- Files status OK
00:14:56:WU00:FS00:0xa3:- Expanded 3845612 -> 4375408 (decompressed 113.7 percent)
00:14:56:WU00:FS00:0xa3:Called DecompressByteArray: compressed_data_size=3845612 data_size=4375408, decompressed_data_size=4375408 diff=0
00:14:56:WU00:FS00:0xa3:- Digital signature verified
00:14:56:WU00:FS00:0xa3:Project: 8579 (Run 0, Clone 0, Gen 495)
00:14:56:WU00:FS00:0xa3:Assembly optimizations on if available.
00:14:56:WU00:FS00:0xa3:Entering M.D.
00:15:02:WU00:FS00:0xa3:Mapping NT from 7 to 7
00:15:06:WU00:FS00:0xa3:Completed 0 out of 500000 steps (0%)
00:26:18:WU00:FS00:0xa3:Completed 5000 out of 500000 steps (1%)
00:37:06:WU00:FS00:0xa3:Completed 10000 out of 500000 steps (2%)
00:47:53:WU00:FS00:0xa3:Completed 15000 out of 500000 steps (3%)
00:58:39:WU00:FS00:0xa3:Completed 20000 out of 500000 steps (4%)
01:09:28:WU00:FS00:0xa3:Completed 25000 out of 500000 steps (5%)
*********************** Log Started 2014-03-08T01:42:21Z ***********************
01:42:21:************************* Folding@home Client *************************
01:42:21: Website: http://folding.stanford.edu/
01:42:21: Copyright: (c) 2009-2014 Stanford University
01:42:21: Author: Joseph Coffland <email@example.com>
01:42:21: Args: --child --lifeline 65 --respawn
01:42:21: Config: /Library/Application Support/FAHClient/config.xml
01:42:21:******************************** Build ********************************
01:42:21: Version: 7.4.4
01:42:21: Date: Mar 4 2014
01:42:21: Time: 20:27:54
01:42:21: SVN Rev: 4130
01:42:21: Branch: fah/trunk/client
01:42:21: Compiler: GNU 4.2.1 (Apple Inc. build 5666) (dot 3)
01:42:21: Options: -std=gnu++98 -O3 -funroll-loops -mfpmath=sse -ffast-math
01:42:21: -fno-unsafe-math-optimizations -msse3 -arch x86_64
01:42:21: -mmacosx-version-min=10.6
01:42:21: Platform: darwin 10.8.0
01:42:21: Bits: 64
01:42:21: Mode: Release
01:42:21:******************************* System ********************************
01:42:21: CPU: Intel(R) Core(TM) i7 CPU 860 @ 2.80GHz
01:42:21: CPU ID: GenuineIntel Family 6 Model 30 Stepping 5
01:42:21: CPUs: 8
01:42:21: Memory: 4.00GiB
01:42:21:Free Memory: 3.39GiB
01:42:21: Threads: POSIX_THREADS
01:42:21: OS Version: 10.9
01:42:21:Has Battery: false
01:42:21: On Battery: false
01:42:21: UTC Offset: 0
01:42:21: CWD: /Library/Application Support/FAHClient
01:42:21: OS: Darwin 13.1.0 x86_64
01:42:21: OS Arch: AMD64
01:42:21: GPUs: 0
01:42:21: CUDA: Not detected
01:42:21: <!-- Folding Slots -->
01:42:21: <slot id='0' type='CPU'/>
01:42:21:Trying to access database...
01:42:29:Successfully acquired database lock
01:42:29:Enabled folding slot 00: READY cpu:7
01:42:29:WU00:FS00:Running FahCore: /usr/bin/FAHCoreWrapper "/Library/Application Support/FAHClient/cores/www.stanford.edu/~pande/OSX/AMD64/Core_a4.fah/FahCore_a4" -dir 00 -suffix 01 -version 704 -lifeline 173 -checkpoint 15 -np 7
01:42:29:WU00:FS00:Started FahCore on PID 224
01:42:32:WU00:FS00:Core PID:228
01:42:32:WU00:FS00:FahCore 0xa4 started
01:42:34:WU00:FS00:0xa4:Folding@Home Gromacs Core
01:42:34:WU00:FS00:0xa4:Version 2.27 (Thu Feb 10 09:46:40 PST 2011)
01:42:34:WU00:FS00:0xa4:Preparing to commence simulation
01:42:34:WU00:FS00:0xa4:- Looking at optimizations...
01:42:34:WU00:FS00:0xa4:- Files status OK
01:42:34:WU00:FS00:0xa4:- Expanded 882159 -> 1469104 (decompressed 166.5 percent)
01:42:34:WU00:FS00:0xa4:Called DecompressByteArray: compressed_data_size=882159 data_size=1469104, decompressed_data_size=1469104 diff=0
01:42:34:WU00:FS00:0xa4:- Digital signature verified
01:42:34:WU00:FS00:0xa4:Project: 9005 (Run 139, Clone 3, Gen 37)
01:42:34:WU00:FS00:0xa4:Assembly optimizations on if available.
01:42:34:WU00:FS00:0xa4:Entering M.D.
01:42:40:WU00:FS00:0xa4:Mapping NT from 7 to 7
01:42:43:WU00:FS00:0xa4:Completed 0 out of 250000 steps (0%)
01:44:34:WU00:FS00:0xa4:Completed 2500 out of 250000 steps (1%)
01:46:18:WU00:FS00:0xa4:Completed 5000 out of 250000 steps (2%)
01:48:02:WU00:FS00:0xa4:Completed 7500 out of 250000 steps (3%)
01:49:47:WU00:FS00:0xa4:Completed 10000 out of 250000 steps (4%)
01:51:31:WU00:FS00:0xa4:Completed 12500 out of 250000 steps (5%)
01:53:17:WU00:FS00:0xa4:Completed 15000 out of 250000 steps (6%)
DEBUG: Config: power = medium main.js:73
DEBUG: NaCl module loading main.js:73
DEBUG: Status: downloading: Downloading the Folding@home software in your Web browser. On your first visit this can take awhile. main.js:73
DEBUG: load progress: 0.0% (0 of 18000000 bytes) main.js:73
DEBUG: load progress: 0.0% (0 of 18446744073709552000 bytes) main.js:73
DEBUG: load progress: 0.0% (17086055 of 18446744073709552000 bytes) main.js:73
DEBUG: load progress: 0.0% (17106340 of 18446744073709552000 bytes) main.js:73
DEBUG: load progress: 0.0% (17125192 of 18446744073709552000 bytes) main.js:73
DEBUG: load progress: 100.0% (17125192 of 17125192 bytes) main.js:73
DEBUG: NaCl module loaded main.js:73
DEBUG: NaCl module responded main.js:73
DEBUG: Status: downloading: Requesting ID. main.js:73
DEBUG: Status: downloading: Requesting ID. main.js:73
DEBUG: Config: id = 0x1ec53118530cef60 main.js:73
DEBUG: Status: downloading: Requesting a work server assignment. main.js:73
DEBUG: Status: downloading: Requesting a work server assignment. main.js:73
DEBUG: WS: {"client_id":"0x1ec53118530cef60","threads":8,"version":"8.0.0","type":"NACL","os":"NACL","user":"Anonymous","team":0,"ts":"2014-02-25T19:30:41Z","ws":"184.108.40.206","project":2981} main.js:73
DEBUG: Status: downloading: Downloading a work unit. main.js:73
DEBUG: Status: downloading: Downloading a work unit. main.js:73
Resource interpreted as Image but transferred with MIME type text/plain: "data:;base64,
DEBUG: WU: {"client_id":"0x1ec53118530cef60","threads":8,"version":"8.0.0","type":"NACL","os":"NACL","user":"Anonymous","team":0,"ts":"2014-02-25T19:30:41Z","ws":"22.214.171.124","project":2981,"server_version":703,"core":176,"core_version":227,"unit_id":"0x000000770893a18a52e6da85807cea17","run":0,"clone":28,"gen":86,"wu_ts":"2014-02-25T19:30:43Z","deadline":"2014-02-26T19:30:43Z","timeout":"2014-02-25T21:54:43Z","credit":10,"compression":"bzip2","checksum":"mwkD5fo9cjLAQsOKM9ip8EGg7mlAmsv5taCtcR9qMQI="} main.js:73
DEBUG: Status: running: Starting work unit. main.js:73
DEBUG: core: checksum verified main.js:73
DEBUG: core: unpacking: frame86.tpr main.js:73
DEBUG: :-) G R O M A C S (-: main.js:73
DEBUG: Groningen Machine for Chemical Simulation main.js:73
DEBUG: :-) VERSION 4.6.5 (-: main.js:73
DEBUG: Contributions from Mark Abraham, Emile Apol, Rossen Apostolov, Herman J.C. Berendsen, Aldert van Buuren, Pär Bjelkmar, Rudi van Drunen, Anton Feenstra, Gerrit Groenhof, Christoph Junghans, Peter Kasson, Carsten Kutzner, Per Larsson, Pieter Meulenhoff, Teemu Murtola, Szilard Pall, Sander Pronk, Roland Schulz, Michael Shirts, Alfons Sijbers, Peter Tieleman, main.js:73
DEBUG: Berk Hess, David van der Spoel, and Erik Lindahl. main.js:73
DEBUG: Copyright (c) 1991-2000, University of Groningen, The Netherlands. Copyright (c) 2001-2012,2013, The GROMACS development team at Uppsala University & The Royal Institute of Technology, Sweden. check out http://www.gromacs.org for more information. main.js:73
DEBUG: main.js:73
DEBUG: :-) Gromacs (-: main.js:73
DEBUG: Option------------------------------------------------------------ main.js:73
DEBUG: -s frame86.tpr Input Run input file: tpr tpb tpa -o traj.trr Output Full precision trajectory: trr trj cpt -x traj.xtc Output, Opt. Compressed trajectory (portable xdr format)-cpi state.cpt Input, Opt. Checkpoint file-cpo state.cpt Output, Opt. Checkpoint file -c confout.gro Output Structure file: gro g96 pdb etc. -e ener.edr Output Energy file -g md.log Output Log file-dhdl dhdl.xvg Output, Opt. xvgr/xmgr file-field field.xvg Output, Opt. xvgr/xmgr file-table table.xvg Input, Opt. xvgr/xmgr file-tabletf tabletf.xvg Input, Opt. xvgr/xmgr file-tablep tablep.xvg Input, Opt. xvgr/xmgr file-tableb table.xvg Input, Opt. xvgr/xmgr file-rerun rerun.xtc Input, Opt. Trajectory: xtc trr trj gro g96 pdb cpt-tpi tpi.xvg Output, Opt. xvgr/xmgr file-tpid tpidist.xvg Output, Opt. xvgr/xmgr file -ei sam.edi Input, Opt. ED sampling input -eo edsam.xvg Output, Opt. xvgr/xmgr file -j wham.gct Input, Opt. General coupling stuff -jo bam.gct Output, Opt. General coupling stuff-ffout gct.xvg Output, Opt. xvgr/xmgr file-devout deviatie.xvg Output, Opt. xvgr/xmgr file-runav runaver.xvg Output, Opt. xvgr/xmgr file -px pullx.xvg Output, Opt. xvgr/xmgr file -pf pullf.xvg Output, Opt. xvgr/xmgr file -ro rotation.xvg Output, Opt. xvgr/xmgr file -ra rotangles.log Output, Opt. Log file -rs rotslabs.log Output, Opt. Log file -rt rottorque.log Output, Opt. Log file-mtx nm.mtx Output, Opt. Hessian matrix -dn dipole.ndx Output, Opt. Index file-multidir rundir Input, Opt., Mult. Run directory-membed membed.dat Input, Opt. Generic data file -mp membed.top Input, Opt. Topology file -mn membed.ndx Input, Opt. Index file main.js:73
DEBUG: Option------------------------------------------------------ main.js:73
Name Value Description
client-type advanced Assigns WUs in late-stage beta if available
client-type bigadv Assigns bigadv WUs on capable systems if available (CPU slot only)
next-unit-percentage X X should be between 90 and 100. It tells when the next WU should be
downloaded after the current WU reaches X percentage
Name Value Description
max-units X X can be any number; 0 is indefinite. It tells when to pause the slot
after X WUs are completed
checkpoint X X is a value between 3 and 30. It will create a checkpoint after X minutes
pause-on-start true FAHClient starts the slot in the pause state
pause-on-start false FAHClient will start the slot normally
max-packet-size small Configures the slot to get small WUs (~5MB)
max-packet-size normal Configures the slot to get normal WUs (~10MB)
max-packet-size big Configures the slot to get big WUs (~500MB)
Usage: FAHClient.exe [[--config] <filename>] [OPTIONS]...
Command line options:
--chdir <string>
Change directory before starting server. All files opened after this
point, such as the configuration file, must have paths relative to the new
--config <string=config.xml>
Set configuration file.
Create a basic configuration file, then exit.
--dump <string>
Dump either 'all' or a specific work unit, identified by its queue ID,
then exit.
Finish all current work units, send the results, then exit.
--help [string]
Print help screen or help on a particular option and exit.
Print application and system information and exit.
Install the application as a Win32 service then exit.
License information and exit.
--lifeline <integer>
The application will watch for this process ID and exit if it goes away.
Usually the calling process' PID.
List the PCI bus devices, which can be helpful for finding GPU vendor and
device IDs.
Print configuration and exit.
Print work unit queue then exit.
Send all finished work units, then exit.
--send-command <string>
Send a command to an already running client.
--send-finish [string]
Finish a slot or all slots on an already running client.
--send-pause [string]
Pause a slot or all slots on an already running client.
--send-unpause [string]
Unpause a slot or all slots on an already running client.
Start Win32 service then exit.
Stop Win32 service then exit.
Uninstall the application as a Win32 service then exit.
Increase verbosity level.
Print application version and exit.
Increase verbosity level.
Configuration options:
The following options can be specified in a configuration file or on the command
line using the following syntax:
--<option> <value>
or when marking boolean values true:
--<option> service-description <string=Folding@home Client>
The description for the Windows service control manager.
service-restart <boolean=true>
Configure Windows service to automatically restart on failure.
service-restart-delay <integer=5000>
The amount of time in milliseconds to delay between restarts of the Windows
Client Control:
client-threads <integer=6>
The number of client processing threads.
cycle-rate <double=4>
The maximum cycle frequency in Hz of client threads.
cycles <integer=-1>
Run at most this many cycles. A value less than zero means run indefinitely.
data-directory <string=.>
The directory, relative to the current directory, where WU data and cores
are stored.
disable-sleep-when-active <boolean=true>
Attempt to keep the system from sleeping when folding, unless on battery.
exec-directory <string=C:\Program Files (x86)\FAHClient>
The directory, relative to the current executable, where executables and
dynamic libraries are located.
exit-when-done <boolean=false>
Exit when all slots are paused.
fold-anon <boolean=false>
Start folding even if not configured.
open-web-control <boolean=false>
Make an operating system specific call to open the Web Control in a browser
once client is fully loaded
config-rotate <boolean=true>
Rotate the configuration file to a backup when saving would overwrite the
previous configuration.
config-rotate-dir <string=configs>
Put rotated configs in this directory.
config-rotate-max <integer=16>
The maximum number of rotated configuration files to keep. A value of zero
will keep all configuration file backups.
Error Handling:
max-slot-errors <integer=10>
The maximum number of errors before a slot is paused.
max-unit-errors <integer=5>
The maximum number of errors before a work unit is dumped.
Folding Core:
checkpoint <integer=15>
Tell cores to checkpoint at least every # minutes.
core-dir <string=cores>
The directory to store core files in.
core-prep <string>
Run this command on cores after they are downloaded. This option is useful
for running Linux cores on BSD machines.
core-priority <string=idle>
Set the core priority. Valid values are: idle or low
cpu-affinity <boolean=false>
If true, try to lock core processes to a fixed CPU
cpu-usage <integer=100>
The maximum percentage of the CPU a core should use. Not implemented by all
gpu-usage <integer=100>
GPU usage as a percent from 10-100
no-assembly <boolean=false>
Tell cores to disable optimized assembly code.
Folding Slot Configuration:
cause <string=ANY>
The cause you prefer to support.
client-subtype <string=STDCLI>
The client subtype
client-type <string=normal>
The client type. Can be 'normal', 'advanced' or 'beta'.
cpu-species <string=X86_PENTIUM_II>
CPU species.
cpu-type <string=AMD64>
CPU type.
cpus <integer=-1>
How many CPUs a slot should use. <= 0 will use all the CPUs detected in the
cuda-index <string>
The CUDA device index of the GPU, counting starts from 0.
extra-core-args <string>
Pass extra arguments to the core.
gpu <boolean=true>
Enable or disable auto-confiugration of GPU slots, requires appropriate
gpu-index <string>
The index of the GPU as detected by the client. This index corresponds
directly to the GPUs listed in the client's '--info' output.
max-packet-size <string=normal>
Max size in bytes of a work unit packet. Can be small=5MB, normal=10MB,
big=500MB or a number.
memory <string>
Override memory, in bytes, reported to Folding@home.
opencl-index <string>
The OpenCL device index of the GPU, counting starts from 0.
os-species <string=UNKNOWN>
Operating system species.
os-type <string=WIN32>
Operating system type.
project-key <integer=0>
Key for access to restricted testing projects.
smp <boolean=true>
Enable or disable auto-configuration of SMP slots, requires appropriate
gui-enabled <boolean=true>
Set to false to disable the GUI. A GUI is not currently supported on all
operating systems.
HTTP Server:
allow <string=127.0.0.1>
Client addresses which are allowed to connect to this server. This option
overrides IPs which are denied in the deny option. The pattern 0/0 matches
all addresses.
connection-timeout <integer=60>
The maximum amount of time, in seconds, a connection can be idle before
being dropped.
deny <string=0/0>
Client address which are not allowed to connect to this server.
http-addresses <string=0:7396>
A space separated list of server address and port pairs to listen on in the
form <ip | hostname>[:<port>]
https-addresses <string=>
A space separated list of secure server address and port pairs to listen on
in the form <ip | hostname>[:<port>]
max-connect-time <integer=900>
The maximum amount of time, in seconds, a client can be connected to the
max-connections <integer=800>
Sets the maximum number of simultaneous connections.
max-request-length <integer=52428800>
Sets the maximum length of a client request packet.
min-connect-time <integer=300>
The minimum amount of time, in seconds, a client must be connected to the
server before it can be dropped in favor or a new connection.
threads <integer=8>
Sets the number of server threads.
HTTP Server SSL:
certificate-file <string>
The servers certificate file in PEM format.
crl-file <string>
Supply a Certificate Revocation List. Overrides any internal CRL
private-key-file <string>
The servers private key file in PEM format.
log <string=log.txt>
Set log file.
log-color <boolean=false>
Print log messages with ANSI color coding.
log-crlf <boolean=true>
Print carriage return and line feed at end of log lines.
log-date <boolean=false>
Print date information with log entries.
log-date-periodically <integer=21600>
Print date to log before new log entries if so many seconds have passed
since the last date was printed.
log-debug <boolean=true>
Disable or enable debugging info.
log-domain <boolean=false>
Print domain information with log entries.
log-domain-levels <string ...>
Set log levels by domain. Format is:
<domain>[:i|d|t]:<level> ...
Entries are separated by white-space and or commas.
i - info
d - debug
For example: server:i:3 module:6
Set 'server' domain info messages to level 3 and 'module' info and debug
messages to level 6. All other domains will follow the system wide log
verbosity level.
If <level> is negative it is relative to the system wide verbosity.
log-header <boolean=true>
Enable log message headers.
log-level <boolean=true>
Print level information with log entries.
log-no-info-header <boolean=true>
Don't print 'INFO(#):' in header.
log-redirect <boolean=false>
Redirect all output to log file. Implies !log-to-screen.
log-rotate <boolean=true>
Rotate log files on each run.
log-rotate-dir <string=logs>
Put rotated logs in this directory.
log-rotate-max <integer=16>
Maximum number of rotated logs to keep.
log-short-level <boolean=false>
Print shortened level information with log entries.
log-simple-domains <boolean=true>
Remove any leading directories and trailing file extensions from domains so
that source code file names can be easily used as log domains.
log-thread-id <boolean=false>
Print id with log entries.
log-thread-prefix <boolean=true>
Print thread prefixes, if set, with log entries.
log-time <boolean=true>
Print time information with log entries.
log-to-screen <boolean=true>
Log to screen.
log-truncate <boolean=false>
Truncate log file.
verbosity <integer=3>
Set logging level for INFO and DEBUG messages.
proxy <string=>
Set proxy for outgoing HTTP connections
proxy-enable <boolean=false>
Enable proxy configuration
proxy-pass <string=>
Set password for proxy connections
proxy-user <string=>
Set user name for proxy connections
Process Control:
child <boolean=false>
Disable 'daemon', 'fork', 'pid' and 'respawn' options. Also defaults
'log-to-screen' to false. Used internally.
daemon <boolean=false>
Short for --pid --service --respawn --log=''
pid <boolean=false>
Create PID file.
pid-file <string=Folding@home Client.pid>
Name of PID file.
priority <string>
Set the process priority. Valid values are: idle, low, normal, high or
respawn <boolean=false>
Run the application as a child process and respawn if it is killed or exits.
service <boolean=false>
Ignore user logout or hangup and interrupt signals
Remote Command Server:
command-address <string=0.0.0.0>
The address to which the command server should be bound.
command-allow-no-pass <string=127.0.0.1>
IP address ranges that are allowed access to the command server with out a
password if the 'password' option is set. These addresses will also have to
be allowed IP based access.
command-deny-no-pass <string=0/0>
IP address ranges that are not allowed access to the command server with out
a password if the 'password' option is set. Overriden by
command-enable <boolean=true>
Set to false to disable the command server.
command-port <integer=36330>
The port to which the command server should be bound.
eval <string>
Evaluate the argument as a script.
password <string>
Set a command server password. Warning, setting a password disables the
default IP address blocking.
script <string>
Run commands from a script file.
Slot Control:
idle <boolean=false>
Only run slot when idle.
max-shutdown-wait <integer=60>
The maxumum amount of time to wait in seconds for a unit to exit on
pause-on-battery <boolean=true>
Pause the client or slot when the OS indicates the machine is running on
battery power.
pause-on-start <boolean=false>
If true the slot will be started in a paused state.
paused <boolean=false>
True of client is paused.
power <string=medium>
Set the client's power level. Valid values are 'light', 'medium' or 'full'.
This setting affects the defaults of several other options such as 'cpus',
'pause-on-battery', etc.
User Information:
machine-id <integer=0>
The machine ID.
passkey <string=>
Your passkey.
team <integer=0>
Your team number.
user <string=Anonymous>
Your user name.
Web Server:
web-allow <string=127.0.0.1>
Client addresses which are allowed to connect to this Web server. This
option overrides IPs which are denied in the web-deny option. This option
differs from the 'allow'/'deny' options in that clients that are not allowed
are served an access denied page rather than simply dropping the connection.
The value '0/0' matches all IPs.
web-deny <string=0/0>
Client address which are not allowed to connect to this Web server.
web-enable <boolean=true>
Set to false to disable the web server.
Web Server Sessions:
session-cookie <string=sid>
The name of the session cookie.
session-lifetime <integer=86400>
The maximum session lifetime in seconds. Zero for unlimited session
session-timeout <integer=3600>
The max maximum amount of time in seconds since the last time a session was
used before it timesout. Zero for no session timeout.
Work Unit Control:
dump-after-deadline <boolean=true>
Dump units if their deadline has passed.
max-queue <integer=16>
Maximum units per slot in the work queue.
max-units <integer=0>
Process at most this number of units, then pause.
next-unit-percentage <integer=99>
Pre-download the next work unit when the current one is this far along.
Values less than 90 are not allowed.
stall-detection-enabled <boolean=false>
Attempt to detect stalled work units and restart them.
stall-percent <integer=5>
Minimum estimated percent work unit completion since last frame before a WU
can be considered stalled, if zero the percentage is ignored.
stall-timeout <integer=1800>
Minimum time, in seconds, since last frame before a WU can be considered
Usage: FAHViewer.exe [OPTIONS]...
Command line options:
--chdir <string>
Change directory before starting server. All files opened after this
point, such as the configuration file, must have paths relative to the new
--config <string=viewer.xml>
Set configuration file.
--help [string]
Print help screen or help on a particular option and exit.
Print application and system information and exit.
License information and exit.
Print configuration and exit.
Increase verbosity level.
Print application version and exit.
Increase verbosity level.
Configuration options:
The following options can be specified in a configuration file or on the command
line using the following syntax:
--<option> <value>
or when marking boolean values true:
--<option> background <string>
Specify an alternative background image to use. Must be in PPM format. The
value 'none' will disable the background image.
basic <boolean=false>
Disable advanced modes which require OpenGL 2.2
blur <boolean=true>
Enable blur (advanced only)
connect <string=127.0.0.1:36330>
An address and port to connect to in the form: <host | IP>:<port>
cycle-snapshots <boolean=true>
Cycle through snapshot frames.
force <boolean=false>
Force running on blacklisted GPUs or in advanced modes
fps <double=8>
Snapshot display speed in frames per second.
fullscreen <boolean=false>
Display in fullscreen mode
height <integer=600>
Screen height
interpolation-steps <integer=9>
The number of interpolated protein views to calculate between snapshots.
mode <integer=4>
Render mode
password <string=>
A password for accessing the remote client
profile <string=default>
Set performance profile. This effects the CPU usage vs. smooth rendering.
Valid options are: lean, default & mean
recompute-bonds <boolean=false>
Recompute bonds from expected bond lengths
show-buttons <boolean=true>
Display buttons
show-info <boolean=true>
Display simulation info
show-logos <boolean=true>
Display logos
slot <integer=0>
Slot on the client to view
test <boolean=true>
Load test data
tpr <string>
Load Gromacs .tpr file
trn <string>
Load Gromacs .trr or .trx file
width <integer=800>
Screen width
wiggle <boolean=true>
Enable atom wiggling which approximates simulation activity
x-rotation <double=0>
Rotation about the X-axis in degrees per second
xtc <string>
Load Gromacs .xtc file
xyz <string>
An XYZ file to read and display
y-rotation <double=10>
Rotation about the Y-axis in degrees per second
zoom <double=1.05>
Zoom level
log <string>
Set log file.
log-color <boolean=false>
Print log messages with ANSI color coding.
log-crlf <boolean=true>
Print carriage return and line feed at end of log lines.
log-date <boolean=false>
Print date information with log entries.
log-date-periodically <integer=0>
Print date to log before new log entries if so many seconds have passed
since the last date was printed.
log-debug <boolean=true>
Disable or enable debugging info.
log-domain <boolean=false>
Print domain information with log entries.
log-domain-levels <string ...>
Set log levels by domain. Format is:
<domain>[:i|d|t]:<level> ...
Entries are separated by white-space and or commas.
i - info
d - debug
For example: server:i:3 module:6
Set 'server' domain info messages to level 3 and 'module' info and debug
messages to level 6. All other domains will follow the system wide log
verbosity level.
If <level> is negative it is relative to the system wide verbosity.
log-header <boolean=true>
Enable log message headers.
log-level <boolean=true>
Print level information with log entries.
log-no-info-header <boolean=false>
Don't print 'INFO(#):' in header.
log-redirect <boolean=false>
Redirect all output to log file. Implies !log-to-screen.
log-rotate <boolean=true>
Rotate log files on each run.
log-rotate-dir <string=logs>
Put rotated logs in this directory.
log-rotate-max <integer=0>
Maximum number of rotated logs to keep.
log-short-level <boolean=false>
Print shortened level information with log entries.
log-simple-domains <boolean=true>
Remove any leading directories and trailing file extensions from domains so
that source code file names can be easily used as log domains.
log-thread-id <boolean=false>
Print id with log entries.
log-thread-prefix <boolean=false>
Print thread prefixes, if set, with log entries.
log-time <boolean=true>
Print time information with log entries.
log-to-screen <boolean=true>
Log to screen.
log-truncate <boolean=false>
Truncate log file.
verbosity <integer=1>
Set logging level for INFO and DEBUG messages.
Viewer key commands:
a Show about screen.
1 Space Filling render mode.
2 Ball & Stick render mode.
3 Stick render mode.
4 Advanced Space Filling render mode. (Requires OpenGL 2.2)
5 Advanced Ball & Stick render mode. (Requires OpenGL 2.2)
6 Advanced Stick render mode. (Requires OpenGL 2.2)
7 Cartoon Space Filling render mode. (Requires OpenGL 2.2)
8 Cartoon Ball & Stick render mode. (Requires OpenGL 2.2)
b Toggle blur (advanced modes only).
i Toggle info display.
l Toggle logo display.
f Toggle fullscreen.
0 Toggle snapshot cycling.
+ Increase snapshot cycle rate.
- Decrease snapshot cycle rate.
[ Decrease slot ID.
] Increase slot ID.
<Space> Toggle rotation.
<Up> Increase X-axis rotation speed in the upward direction.
<Down> Increase X-axis rotation speed in the downward direction.
<Left> Increase Y-axis rotation speed in the left direction.
<Right> Increase Y-axis rotation speed in the right direction.
<Page Up> Zoom in.
<Page Down> Zoom out.
<ESC> Quit popup.
q Quit application or popup.
h Show help screen.
Viewer mouse commands:
Left Drag Rotate protein.
Wheel Zoom in and out.
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text:
NicC necesitaba un nuevo diseño de tema de wordpress y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 106 diseños de 9 diseñadores freelance.
Nicola Cadwell http://www.nicolacadwell.com
I'm a business consultant specialising in CRM (Customer Relationship Management). I've worked for companies such as Microsoft, The Jim Henson Company, and Bell Canada and now I'm starting up as an independent business and IT consultant.
I'm very professional but also laid back, I'm sociable and people orientated. I'm a 37yr old female and I live in Vancouver, Canada.
This is my first website so I'll be targetting new customers. Companies implementing a new CRM system, companies requiring a project manager, Microsoft partners requiring assistance with building their CRM practice. No specific geographic target, will travel for work.
I want a website that will wow my potential customers, when they go to the site I want them to know I'm a professional and recognize this is not just a wordpress template I've picked up from somewhere like siteground.com.
A simple, elegant logo incorporating my initials N and C would be great for the home page and for use on a business card.
I don't want the blog as the home page but I will want a blog page and an About Nicola page, Services page, Client & Employers page and Contact.
I will want to put a head shot on the home page and maybe another photo on the About Nicola page
The website should also have
Receive updates via email,
Facebook, Twitter and Sharethis icon for social distribution
Industry news import via RSS
No coding required.
Layouts, Colour scheme, graphics are all up to you, I just want something professional and elegant.
Please email or comment for any information, I'll try to give quick feedback, thank you, Nicola.

subset: commoncrawl


text:
All News Releases By Date
Lufkin Facility Receives EPA Greenhouse Gas Permit; $443.8 million in economic development and job creation
Release Date: 08/01/2014
Contact Information: Joe Hubbard or Jennah Durant at 214-665-2200 or email@example.com
DALLAS – (Aug. 1, 2014) The U.S. Environmental Protection Agency (EPA) has issued a final greenhouse gas (GHG) Prevention of Significant Deterioration (PSD) construction permit to the Pinecrest Energy Center power plant in Lufkin, Texas. The project proposes to construct a new natural gas-fired combined cycle electric generating plant.
"Every day we are hard at work to help Texas businesses take advantage of new opportunities for growth and make a positive difference on addressing climate," said Regional Administrator Ron Curry. "This project is another step toward a cleaner economy and greener energy future for Texans."
Once completed the plant will have two new natural gas-fired combined cycle turbines, two natural gas-fired duct burner systems with heat recovery steam generators, a firewater pump engine, emergency generator and an auxiliary boiler. The projected cost of the project is $443.8 million and will produce fifty new permanent jobs.
In June 2010, EPA finalized national GHG regulations, which specify that beginning on January 2, 2011, projects that increase GHG emissions substantially will require an air permit.
EPA believes states are best equipped to run GHG air permitting programs. Texas is working to replace the federal implementation plan with its own state program, which will eliminate the need for businesses to seek air permits from EPA. This action will increase efficiency and allow industry to continue to grow in Texas.
For all of the latest information on GHG permits in Texas please visit: https://yosemite.epa.gov/r6/Apermit.nsf/AirP
EPA has finalized 45 GHG permits in Texas, proposed an additional seven permits, and currently has 14 additional GHG permit applications under review and permit development in Texas.
Connect with EPA Region 6:
On Facebook: https://www.facebook.com/eparegion6
On Twitter: https://twitter.com/EPAregion6
Activities in EPA Region 6: https://www.epa.gov/aboutepa/region6.htm
EPA is taking a variety of actions to cut Greenhouse Gas emissions and address the impacts of climate change. Most recently, EPA released a Clean Power Plan for existing power plants to cut carbon pollution by 30 percent below 2005 levels. Learn more about EPA's actions at https://www.epa.gov/climatechange/.
Search this collection of releases | or search all news releases
View selected historical press releases from 1970 to 1998 in the EPA History website.


text:
Product Description
Find the right information and present it the right way
Take full advantage of all SQL Server Reporting Services can do for you
Without a way to interpret it, the data in your database just sits there doing nothing. Now you have help! This handy guide shows you how to retrieve data and create reports with the newest version of SQL Server Reporting Services, so you can deliver both hard copy and interactive, Web-based reports that tell your story.
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text:
Intel has introduced its SOA Security Toolkit as a release candidate. Part of Intel's family of XML tools, the toolkit is a high-performance software module that addresses the confidentiality needs of services-oriented architectures (SOA) by providing XML digital signatures, encryption, and decryption capabilities for SOAP protocol messages.
The Intel SOA Security Toolkit 1.0 for Java environments is a high-performance policy-driven API available for Linux and Windows. Compliant with WS-security 1.0/1.1 and SOAP 1.1/1.2 standards, the toolkit focuses on confidentiality, integrity and non-repudiation for SOA environments. This toolkit enables encryption and decryption of SOAP message data, digital signature and verification via a wide range of security algorithms, using industry standards, for both servers as well as application environments.
The SOA Security Toolkit supports the following functions:
- Digest Methods: SHA1, SHA256, SHA384, SHA512, MD5
- Signature Methods: DSA with SHA1, RSA with SHA1, MD5, SHA256, SHA384 or SHA512.
- Encryption Methods--Block & stream: AES128-CBC, AES192-CBC, AES256-CBC, 3DES-CBC;
- Key Transport: RSA-OAEP with all optional, RSA-V1.5, RSA no padding; Symmetric Key Wrap: 3DES-KW, AES128-KW, AES192-KW, AES256-KW
- X.509 Public Key Infrastructure certificates
- Canonicalization (c14n) methods; Exclusive
The toolkit lets users provide their own XML policy file as an input. Through this policy file, users can specify for the API security policy engine which key provider and trust manager to instantiate, using either a custom or the default class loader implementation. The security policy engine then applies the specified policy, obtaining the keys and certificates through the specified key provider and perform the trust check using the specified trust manager. The toolkit supports all types of X509 certificates, private, and shared keys.


text:
This Game of Thrones inspired Logistics house flag is for the individual who knows the sacrifice it takes to be a member of this organization. Allow us to bring what you're passionate about to the forefront of your life. Hang this flag in your office, gym, garage, bay, or somewhere you want others to see where your allegiance lies.
Customize this wall flag with a different motto, DUI, color, or additional text (i.e., Name, PLT, Date) starting at $4.95. Message or E-mail us a short description of what you would like customized, and we will be sure to meet your needs. All requests can be e-mailed to firstname.lastname@example.com or click the message us button located on the bottom left of your screen.
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text:
From the video box:
A dutiful robot named Robby speaks 188 languages. An underground lair provides astonishing evidence of a populace a million years more advanced than Earthlings. There are many wonders on Altair-4, but none is greater or more deadly than the human mind.
Forbidden Planet is the granddaddy of tomorrow, a pioneering work whose ideas and style would be reverse-engineered into many cinematic space voyages to come. Leslie Nielsen portrays the commander who brings his space cruiser crew to the green-skied Altair-4 world that's home to Dr. Morbius (Walter Pidgeon), his daughter (Anne Francis), the remarkable Robby, and to a mysterious terror. (1956, color)
Mark says:
Not many people would disagree that Forbidden Planet is one of the best sci-fi films that came from the 1950s. Produced by a major studio (MGM) and laden with stunning visuals and effects, Forbidden Planet is a true sci-fi classic.
But it's not just the production values and special effects that give Forbidden Planetits classic status. The storyline and concepts are equally intriguing, giving this movie much more dimension than similar sci-fi pictures of the time. Here's a terribly over-simplified synopsis:
Spacecruiser C-57-D, under the command of Commander John J. Adams (Leslie Nielsen), is sent on a mission to the planet Altair-4 to investigate the destiny of the Bellerphon, a fully manned craft that landed on Altair-4 twenty years previous but has not been heard from since. They discover the only survivor of the Bellerphon is Dr. Edward Morbius (Walter Pidgeon), who is suspiciously anxious for the rescue party to return to Earth without him.
Morbius explains that the crew of the Bellerphon, after making the decision to return to Earth, were "literally torn limb from limb" by an invisible force. Only Morbius and his wife seemed to be immune to the force. The Bellerphon itself was vaporized while trying to leave the planet (Morbius and his wife, fascinated with the new world, were not aboard the ship.)
Within the year, Morbius's wife died of natural causes, but not before giving birth to a beautiful daughter, Altaira (Anne Francis). Morbius, Altaira, and a fantastic robot called Robby have been the only inhabitants of the planet since. They have never again been bothered by the destructive force.
Commander Adams needs further instructions from home base regarding Dr. Morbius. Unfortunately, building a communication device powerful enough to reach Earth takes several days, even with the help of the super-strong Robby. Meanwhile, an invisible beast enters the ship and kills Chief Engineer Quinn (Richard Anderson, who you might recognize as Oscar Goldman from the Six Million Dollar Man tv series).
The death of Quinn is strikingly similar to deaths described by Dr. Morbius concerning the crew of the Bellerphon. Commander Adams decides that it is time to confront Morbius and find out exactly what he knows about the planet Altair-4.
Dr. Morbius relates the history of the Krell, an ancient race "a million years more advanced" than Earthlings that once inhabited the planet. The Krell were a benevolent people evolved to a point of unsurpassed intellectual ability. Morbius was able to ascertain this through surviving Krell documents and machinery. Inexplicably, the Krell vanished overnight while on the verge of their greatest intellectual achievement, a society completely devoid of "instrumentation."
Morbius also relates how his intellectual capacity has been doubled by using one of the Krell machines. The machine proved fatal to one of Morbius's crew mates, and he forbids the commander or any of his crew to use it.
Of course, the extinction of the Krell is directly linked to the events now afflicting the men of Spacecruiser C-57-D. I will not reveal the answer to the mystery here out of respect for the uninitiated.
Anne Francis (who also starred in the title role of the tv series, Honey West) is superb in her portrayal of the alluring, intelligent, yet naive Altaira. She conveys a sense of innocence as well as an aura of sex appeal, and easily competes with the astounding sets and visuals of the film.
Leslie Nielsen (Day of the Animals, Dracula: Dead and Loving It) is competent in the role of Commander John J. Adams. Commander Adams is personable, but can also be authoritative when need be. Warren Stevens, portraying Lt. 'Doc' Ostrow, is the commander's right-hand man and seems to be intellectually superior to him. As Dr. Morbius sarcastically points out, you don't need brains to lead, "just a loud voice."
Walter Pidgeon (Voyage to the Bottom of the Sea) is convincing as the stubborn Dr. Edward Morbius, but at times he seems bored with the part. Dr. Morbius is obviously an important character, but when the movie drags (as it sometimes does) it is primarily during his scenes. I think more editing could have helped the situation.
There is plenty of humor in Forbidden Planet. The crew is playful and even Commander Adams pulls an occasional prank. The casual humor is not distracting, however, certain scenes with the cook (played by Earl Holliman) are almost obnoxious in their attempts to be funny. The sequences involving Holliman and Robby are particularly embarrassing. Robby belching after analyzing the cook's bourbon seems incredibly out of place for such a serious sci-fi effort.
Bebe and Louis Barron composed the "electronic tonalities" (original music) for Forbidden Planet. The tonalities not only add to a futuristic atmosphere but also serve as some of the sound effects. As the video box description states, this was "the first all-electronic musical soundscape in film history."
Story by Irving Block (War of the Satellites, Kronos) and Allen Adler. Screenplay by Cyril Hume.
Directed by Fred M. Wilcox.
Scene to watch for: The "Monster from the Id" shows its shape and size while crashing through the disintegrator beam in an attempt to attack the ship. (Side note: Every time I watch this segment I'm put in mind of the animated "Judge" from Pink Floyd's The Wall.)
Line to listen for: "Sorry miss, I was giving myself an oil-job."
Trivia: Forbidden Planet is loosely based on William Shakespeare's The Tempest.
Mark's Rating: ! ! ! ! ½ out of 5.


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Topic: AAS Studies/Literature & Newbie Cycle Info (Read 251347 times)
Getbig V
Posts: 5661
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #100 on:
August 19, 2008, 10:02:02 AM »
Quote from: Overload on August 19, 2008, 05:20:31 AM
Norma is some of the best stuff there is dude...
If it's real, unfortunately they are faked more often than not.
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Getbig V
Posts: 7465
KO Artist
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #101 on:
August 19, 2008, 10:42:09 AM »
Quote from: Emmortal on August 19, 2008, 10:02:02 AM
If it's real, unfortunately they are faked more often than not.
Yes, and it is getting much worse.
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Getbig II
Posts: 20
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #102 on:
October 06, 2008, 05:19:58 AM »
I have a couple questions, if you have time I would love to get some expert feedback
As far as Winny, I was thinking of starting an 8 week cycle soon but I have seen some conflicting information.
1) I know that Winny is generally used as a cutting steroid and I am fine with that. But I have seen some profiles that recommend coupling with Test E if you wanted to see more gains in mass. Would this be effective?
A) If so what dosage would you recommend with the stack?
2) I have also seen recommendations for 3cc's a week instead of 50mg's a day? This is what I would rather do but wondering what your take was.
3) I also saw Deca recommended as a stack for size, Deca has some great properties and I would like to use it just for the ease in joint pain and what not but would I increase my chances of sexual side effects? IE decrease sex drive? Deca dick...
4) If both deca and test would be good for increased gains which is better?
I definitely want the cutting properties and getting lean is pretty important to me, but if I could couple that with some mass building obviously that would be ideal, just wondering if you guys had any thoughts to help me out.
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Arnold jr
Getbig V
Posts: 7247
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #103 on:
October 06, 2008, 10:21:41 PM »
Quote from: Wahawk on October 06, 2008, 05:19:58 AM
I have a couple questions, if you have time I would love to get some expert feedback
As far as Winny, I was thinking of starting an 8 week cycle soon but I have seen some conflicting information.
1) I know that Winny is generally used as a cutting steroid and I am fine with that. But I have seen some profiles that recommend coupling with Test E if you wanted to see more gains in mass. Would this be effective?
A) If so what dosage would you recommend with the stack?
2) I have also seen recommendations for 3cc's a week instead of 50mg's a day? This is what I would rather do but wondering what your take was.
3) I also saw Deca recommended as a stack for size, Deca has some great properties and I would like to use it just for the ease in joint pain and what not but would I increase my chances of sexual side effects? IE decrease sex drive? Deca dick...
4) If both deca and test would be good for increased gains which is better?
I definitely want the cutting properties and getting lean is pretty important to me, but if I could couple that with some mass building obviously that would be ideal, just wondering if you guys had any thoughts to help me out.
You need to pick one, either getting leaner or bulking up more...steroids do not posses the magic ability to give you massive amounts of both...don't believe the hype.
Certain steroids are often used in cutting cycle rather then bulking cycles, but there are no technical "cutting" steroids. You can get lean on just about anything.
Test and deca are both solid drugs, but they are not similar or nor does one replace the other. If you pick just one, go with test, much safer and effective for what you're wanting. Deca alone can often give you the side effects you're concerned with...test alone cannot. Now test with deca is a good stack.
Winny, can be used bulking or cutting effectively. Now by saying you want to run 3cc's a wk, well this doesn't clarify an amount. Most injectable winny is dosed at 50mg/ml so in most cases 3cc would equal 150mg. But some winny is dosed higher so you need to know the dosage of the winny you have.
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Getbig V
Posts: 5661
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #104 on:
October 06, 2008, 10:37:52 PM »
Quote from: Arnold jr on October 06, 2008, 10:21:41 PM
Winny, can be used bulking or cutting effectively. Now by saying you want to run 3cc's a wk, well this doesn't clarify an amount. Most injectable winny is dosed at 50mg/ml so in most cases 3cc would equal 150mg. But some winny is dosed higher so you need to know the dosage of the winny you have.
Wahawk, one thing I'd add about using Winny in a bulk is that it tends to dry your joints out for a lot of guys which typically means bye bye to heavy lifting. I'm not even a fan of using it in a cut either, but that's just me personally. You really can't know how it will effect you until you run it, everyone reacts differently to compounds. But just keep that in mind for future reference.
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the Chance
Getbig I
Posts: 1
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #105 on:
October 14, 2008, 03:29:06 PM »
im thinking about trying a cycle. I know alittle about them but would like to know alittle more..iv done them before but not very long
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Getbig I
Posts: 1
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #106 on:
October 18, 2008, 11:26:09 AM »
ok ive done all the reading and im sure i would like to try a newbie cycle im 39 5'9 175 cut north of chicago but not making any gains anymore at least very little can someone give me some advise on how to get started
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Getbig II
Posts: 24
to live is to fight
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #107 on:
October 22, 2008, 07:50:15 PM »
Awesome info, I am very grateful for this board and this post!
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Getbig II
Posts: 20
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #108 on:
October 24, 2008, 04:21:13 PM »
Is winny supposed to be a milky color? the brand is British Dragon.
Thanks as always.
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Getbig II
Posts: 20
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #109 on:
October 24, 2008, 04:29:07 PM »
Sorry, forgot.
I don't have any experience with the little 50ml bullet looking capsules. How do you go about getting the gear into a syringe with those?
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Arnold jr
Getbig V
Posts: 7247
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #110 on:
October 24, 2008, 10:09:31 PM »
Quote from: Wahawk on October 24, 2008, 04:21:13 PM
Is winny supposed to be a milky color? the brand is British Dragon.
Thanks as always.
Quote from: Wahawk on October 24, 2008, 04:29:07 PM
Sorry, forgot.
I don't have any experience with the little 50ml bullet looking capsules. How do you go about getting the gear into a syringe with those?
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Getbig II
Posts: 20
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #111 on:
October 25, 2008, 01:30:42 AM »
Thanks Arnold Jr,
They are the amps, thats what I meant. I guess you bust the cap off and put it into the syringe. Never mind.
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Getbig I
Posts: 1
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #112 on:
October 30, 2008, 01:45:51 PM »
So this may sound stupid to some people but I just recently started thinking of steroids and im set on starting a cycle of Anavar(Oxandrolone) and most people suggest between 20-100mg/day for it to really work to its full potential...so if i wanna take about 60-80mg/day and they come in 10mg tabs would that mean that I would need to take 8 tabs at the same time to get my 80mg/day or do i spread it out equally through out the day
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Getbig III
Posts: 490
fundamentalist atheist - guns + religion don't mix
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #113 on:
November 14, 2008, 01:06:04 PM »
80mgs a day is good. spread the dose throughout the day, preferably with meals. don't forget, tho mild, anavar can still affect your natural test - have your pct pre-planned. not otc either...
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Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #114 on:
November 18, 2008, 11:30:46 AM »
Quote from: Wahawk on October 25, 2008, 01:30:42 AM
Thanks Arnold Jr,
They are the amps, thats what I meant. I guess you bust the cap off and put it into the syringe. Never mind.
You break the top off of the amp then draw the gear out with the syringe.
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Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #115 on:
November 27, 2008, 08:43:01 AM »
Always run a PCT. You will get shut down even from var. Maybe not as much, but it still shuts you down. Provirion will shut you down to an extent.
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Getbig II
Posts: 111
Whatever doesn't kill me, Makes me Stronger!
Re: Thinking about doing steroids?? READ THIS!! Newbie Info
Reply #116 on:
December 12, 2008, 06:20:26 PM »
Good info..thanks AJ and all..
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Re: AAS Studies/Links/Literature
Reply #117 on:
January 14, 2009, 01:56:49 PM »
Interesting study on the bioavailability of HCG with IM and SubQ injections.
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Getbig V
Posts: 5661
Re: AAS Studies/Links/Literature
Reply #118 on:
January 30, 2009, 11:50:06 AM »
Good read, grabbed from another board:
The Pharmacology Of Anabolic Steroids
Written by By Dan Gwartney, MD
Wednesday, 28 January 2009
Anabolic-androgenic steroids (AAS) are immensely popular with athletes and individuals interested in building muscle mass because they are reliable and effective.1 Much like any other drug, licit or illicit, patients or users can easily administer the drug(s) and readily predict the bodys response with the slightest degree of experience. Sadly, because AAS are so simple, most users fail to even attempt to understand how the drugs work and why different AAS provide different results. Further, safety is rarely considered until a problem occurs.
Pharmacology is the study of the factors involved with how a drug enters and works in the body, the various ways the cells and systems regulate the processes affected and how the body clears the drug. Despite the fact that AAS are based upon an endogenous hormone (testosterone) and have been utilized as a pharmaceutical product for over 50 years, the complete pharmacology of AAS remains undetermined, even though a significant number of men suffer from symptoms of androgen deficiency, with associated health consequences including cardiovascular disease and earlier mortality.2-4 Fortunately, there is a substantial body of published research in the field, nicely reviewed by Dr. Andrew Kicman of the Department of Forensic Science and Drug Monitoring at Kings College London (England) in the British Journal of Pharmacology.5 While the collective knowledge in the field of AAS is incomplete (as it is with every other drug, such being the nature of science), it is sufficient to develop a working understanding of AAS and suggest potential research to improve safety and efficacy.
Kicmans review is organized in excellent fashion and comprehensively referenced. Those truly interested in learning about AAS, which should include anyone using or prescribing such drugs (licitly or illicitly), would be well-served to read the review. The British Journal of Pharmacology has provided free access to the article at their website:
As has been stated repeatedly, AAS contain or are derivatives of the natural male sex hormone, testosterone. Knowing this, it is not surprising that AAS affect a myriad of tissues which respond to testosterone, including: reproductive tissues, muscle, bone, hair follicles, liver, kidneys, brain, white and red blood cells. These effects are usually divided into androgenic (referring to masculinization) and anabolic (primarily protein building in muscle and bone). As the effects of AAS on fetal development, pre-adolescents and females add greatly to the complexity of the topic, this article is restricted to the effects of AAS on post-pubescent males.
Skeletal Muscle, Testosterone And Hypertrophy
The effects of AAS on specific tissue-types (fat cells versus muscle versus brain, etc.) depend in part on how that tissue enzymatically processes androgens and whether a particular AAS is protected against such enzyme attacks.6 In tissue related to the reproductive system, testosterone acts as a prohormone, being converted to the more androgenic DHT by the enzyme 5-alpha-reductase, as happens in the prostate; similarly, testosterone is converted to estradiol (an estrogen) in breast tissue and fat cells by the enzyme aromatase. Many tissues convert testosterone into both DHT and estradiol (i.e., brain, bone).
However, the primary tissue of interest, relative to AAS use for physique or performance improvement, is skeletal muscle. Skeletal muscle includes the familiar biceps, pecs, quads and other muscles that aid in movement. Two other classes of muscle include smooth muscle, which is present in the gut and blood vessels, the second being cardiac (heart) muscle. AAS may affect these other two types, particularly the heart, but these effects are outside the scope of this article. Skeletal muscle does not contain detectable levels of 5a-reductase, but does have significant aromatase activity.7,8 Thus, testosterone is the primary androgen responsible for muscle hypertrophy; the role of estrogen in skeletal muscle remains unknown at this time.
Testosterone affects the muscle cell by activating genomic and non-genomic targets. The genomic effects of testosterone involve the classically understood mechanism of testosterone entering the cytoplasm (the inside of the cell), binding with an androgen receptor (AR) and traveling together into the nucleus of the cell. Once in the nucleus, the testosterone-AR complex turns on or off specific genes (segments of DNA), resulting in muscle cell hypertrophy (growth). However, the genomic signaling is not so simple. Every cell contains varying concentrations of co-regulators which can promote or inhibit the ability of the testosterone-AR complex to activate genes.9 Unfortunately, this is an area that is poorly understood, so until further research emerges, the relative importance of these co-regulators remains unclear.
Testosterone can also affect receptors and enzymes directly. Receptors imbedded in the membrane or in the cytoplasm can be activated by testosterone and have a near-immediate effect on cell function and behavior.10,11 This is most evident in mating-related or risk-taking behaviors. Researchers at Lehigh University recently published a study demonstrating that the reflexive testosterone release of male mice in mating situations directly and rapidly increased arousal and mounting of a receptive female.12 In other words, when a new, sexually receptive female was introduced into a male mouses pen, his body produced a surge of testosterone that made him more quickly get aroused and mount the female. Additionally, reductions in anxiety and pain perception have been reported, as well as increases in behavior-reward association.13 This effect has not been as directly measured in humans, but advertising executives have been aware of a similar phenomenon in men for centuries. Sociologists and neurologists have confirmed that men will take greater sexual and financial risks (i.e., failing to use a condom, gambling) when sexually aroused or even when simply presented with an erotic image.14,15
Clearly, the near-immediate response seen in such situations and replicated by injecting a rapidly available form of testosterone in mice, requires a much faster mechanism than the genomic effects of testosterone provide.16 Genomic changes take hours to days to manifest, while non-genomic take seconds to minutes.
A third avenue by which AAS appear to promote muscle growth is by inhibiting the catabolism (muscle wasting) caused by cortisol and other glucocorticoids. The balance between anabolism (muscle building) and catabolism (muscle wasting) is generally attributed to the testosterone-cortisol ratio; of course, there are many other factors involved.17 Testosterone is generally considered to promote anabolism, while cortisol promotes catabolism. However, there is some research supporting the idea that testosterone may also reduce catabolism, either by attaching to the glucocorticoid (cortisol) receptor and blocking the catabolic effect or reducing the concentration of glucocorticoid receptors by turning down the manufacturing signal from the nucleus (DNA).5
Chemical Structure Of AAS
AAS differ from testosterone by minor changes in the chemical structure that can dramatically affect the absorption, androgenicity, metabolism, receptor affinity, conformation of the AAS-AR complex and potency of each specific AAS. Testosterone is not a drug that can be taken orally because it is rapidly degraded and eliminated by enzymes in the intestines and liver.18 However, when the 17-carbon is bound to a small carbon chain (17a-alkylation), the AAS is protected from these enzymes. Unfortunately, 17a-alkylated AAS are associated with liver damage and potentially life-threatening tumors, as well as negative changes in (good) HDL cholesterol.19 Certain AAS will place a double-bond at the 1-carbon which provides some, but less, protection from degradation. The prototypical oral AAS, Dianabol, combined with the use of 17a-alkylation and a 1-carbon double bond; oral-turinabol, the AAS most commonly used by East Germany during their era of Olympic dominance, adds a chlorine to the 5-carbon, conferring further protection. Certainly, there are many other possible modifications but these represent the more commonly encountered oral AAS. The effects of oral AAS are short-lived, as they are cleared in a matter of hours.
Common injectable AAS are naturally produced androgens (testosterone, nortestosterone, boldenone) that are bound to a fatty acid by an ester bond at the 17-carbon. Rather than protecting against enzymes, as the 17a-alkylated AAS are, the 17b-esters merely increase the time that the bound AAS remains in an oil globule, after injection, before it circulates through the body. Once an AAS-ester hits the bloodstream, the fatty acid is rapidly split off by enzymes called esterases. A long fatty acid makes the AAS more lipid-soluble and it will disperse from the injected oil depot more slowly (days to weeks). Without the addition of an ester, injected testosterone will clear the system in a matter of hours.
AAS can also be placed into gels or patches containing permeation-enhancers that allow the AAS to be absorbed across the skin or the gum/cheeks of the mouth.20 Intranasal testosterone is also being developed, as the lining of the nose and airways is also an effective site for absorption.21 AAS absorbed across skin or mucosa does not need to be modified. Transdermal and mucosal testosterone do not maintain elevated concentrations for long after the application (patch, gel or spray) has been removed. Thus, they are applied daily.
In the body, the various AAS do not provide identical responses to testosterone or each other. The major differences are generally believed to be due to whether the AAS used can be converted into estrogen via the aromatase pathway, DHT via 5a-reductase, both or neither.6 Even the non-steroidal SARMs (meaning they are not based upon testosterone) being developed by numerous pharmaceutical companies (still) seeking to dissociate anabolic from androgenic effects are believed to be less androgenic, because they are not affected by 5a-reductase.6 Drugs that 5a-reductase can convert are typically changed into more androgenic metabolites, leading to hair loss, acne and prostate enlargement. 19-Nortestosterone (nandrolone, Deca) is the exception to this rule, as it actually converts to a less androgenic compound.22 AAS that can be 5a-reduced typically provide less dramatic mass and strength gains, may be associated with joint pain, but tend to result in higher quality gains, as there is little water retention and fat loss appears to be enhanced.
AAS that can be aromatized tend to provide greater mass and strength gains, but also predispose users to increased water retention and fat gain. These effects could logically be anticipated, as skeletal muscle does not contain 5a-reductase but does produce aromatase, suggesting that the more androgenic DHT is not the preferred anabolic androgen, rather testosterone appears to be so. Also, the encoded production of estradiol in muscle suggests that aromatizable AAS provide supplementary stimuli, promoting growth that would not be generated by 5a-reduced or poorly aromatizable AAS. In fact, the poorly aromatizable 19-nortestosterone (Deca) provides lesser mass and strength gains than testosterone despite having a much higher anabolic:androgenic ratio.
Nuclei: The Foreman Of Muscle Growth
It is also important to note the difference in effect of various AAS at non-skeletal muscle tissue. Satellite cells are stem-cell like in that they allow for the growth of muscle tissue. Rather than increasing cell number though, satellite cells enter existing skeletal muscle cells and add to the number of nuclei. This makes little sense at first, as one would think the addition of more muscle cells would be of greater benefit than cells with more than one nucleus, especially since nearly every other cell in the body has only one nucleus (the DNA center). However, it has been shown that skeletal muscle size is directly related to the number of nuclei present in a cell; more so, the nuclei function best if they are located in the center of the cell.23 When satellite cells add nuclei to the skeletal muscle cell, the potential for growth is increased. Confusing as this is, consider each nucleus a foreman who can only manage 10 laborers; if a company wants to increase production, it cannot simply add more laborers but must also add foremen. Thus, for every additional foreman, the company can grow by 10 more laborers. Without adding foremen, the additional laborers would not know what jobs to perform and the company would not grow.
Satellite cells exist between muscle fibers, but do not migrate into muscle cells without being prompted by mechanical and hormonal signals, such as weight training and AAS. Satellite cells come from a pool of even more primitive cell types, referred to as pluripotent stem cells. This long term describes cells that can become more than one type of cell. In this specific case, these pluripotent stem cells can become skeletal muscle or fat cells. To no ones surprise, when exposed to threshold concentrations of testosterone or certain other AAS, pluripotent stem cells begin the process of becoming myogenic (meaning progressing toward becoming skeletal muscle) as opposed to adipogenic (or becoming fat cells). Thus, in an environment of higher androgen:estrogen presence, changes in the stem cell pool would promote muscle growth and reduce the predisposition toward gaining fat.24
Many people find it difficult to understand the relevance of AR (androgen receptor) binding, as AAS with a higher AR-affinity (meaning how tightly they connect with the androgen receptor) are not necessarily more potent at promoting anabolic or androgenic effects. DHT has a higher AR-affinity than testosterone, but is less effective at promoting muscle growth; 19-nortestosterone has a higher affinity than testosterone, but is less effective in generating androgen-based changes in the prostate. In part, this may be due to the co-regulators mentioned earlier. Very few of these co-regulators have been identified and none are well understood. In each type of tissue (prostate, skeletal muscle, skin, heart, etc.), there are different co-regulators, accounting for many of the differences seen among various tissue types.25 The co-regulators attach onto the AAS-AR complex and help or hinder the complex attaching onto and activating the androgen-sensitive genes in the DNA.26 To attach onto the AAS-AR complex, the co-regulators look for a specific shift in the shape of the molecule, anticipating the openings that would be present if testosterone or DHT combined with the AR. When a synthetic AAS attaches, the AAS-AR may not shift completely, failing to generate the necessary opening for the co-regulators.
In the absence of a complete AAS-AR-co-regulator complex, the genes may not be stimulated to the same degree, if at all. As a number of genes are turned on by testosterone-AR, the possibility exists that changes may be seen in certain genes being activated while others proceed as if the AAS is a completely natural hormone. As stated, this is an area just beginning to be understood and will undoubtedly provide future advancements in this area.
All AAS Are Not Created Equal
In summary, though the class of drugs is primarily based upon the male sex hormone testosterone, AAS cannot be viewed as simply substituting or even increasing the natural production of testosterone. Testosterone, which is regulated through a negative feedback system (meaning if too much is produced, the manufacturing signal from the brain is reduced), pulses throughout the day several times, giving a peak-and-valley rhythm, with highs being two to three times the lows.27 Testosterone can be converted into metabolites with greater estrogenic or androgenic properties, depending upon the tissue the hormone reaches. Once the signal has been generated, the body deactivates and clears these hormones to ready the body for the next signal. These signals can be rapid, acting through non-genomic pathways, directly altering receptor sensitivity, enzymes or ion channeling; such actions occur in seconds to minutes and do not always require the androgen to enter the cell. Slower but more permanent responses are typically generated when testosterone (or a metabolite) combines with an androgen receptor, the pair then connecting co-regulators present in the cell before traveling to the cell nucleus (DNA center) where specific genes are activated or suppressed. Testosterone may also partially block the catabolic response to cortisol by competing with the glucocorticoid receptor or reducing a cells production of glucocorticoid receptors.
When minor alterations are made to testosterone (or related steroids), these changes affect how the body processes and responded to the drug. AAS can be taken orally if protected against the first-pass clearance of the liver and intestines, provide elevated concentrations for weeks to months when injected as a long-chain ester, or absorb across the skin or mucosal membrane of the mouth or nose. AAS are reliably anabolic, but the effects vary depending upon the drug used. Some carry significant androgenic potential, possibly leading to hair loss or urinary retention; others are more estrogenic and may stimulate the growth of breast tissue in men or promote water retention and fat gain. Skeletal muscle is stimulated rapidly but the majority of anabolic processes are based upon the activation of growth-promoting genes in the cell nucleus.
AAS must bind with the androgen receptor and combine with co-regulators to generate this anabolic stimulation. However, if the chemical changes made to the AAS alter the shape of the androgen receptor significantly, then the co-regulators may not be able to effectively combine with the AAS-AR complex and gene stimulation may be reduced or fail. Maximal skeletal muscle growth cannot be achieved unless the cell incorporates additional nuclei, which are provided by satellite cells. Satellite cells are prompted to combine with muscle cells under the influence of androgens and other cell factors produced by exercise. Satellite cells arise from pluripotent stem cells, which can become either fat cells or muscle cells. In an androgen-rich environment, pluripotent stem cells are influenced toward muscle development and away from fat development. This may account for some of the cutting effect seen with non-aromatizable AAS.
Clearly, there is much to digest in this article, but also a recognition of much still to be learned. Unquestionably, all AAS are not created equal and the tendency for regulators, researchers and the media to regard all AAS as the same is dangerous and misguided. As with any class of drug, simple molecular changes can result in drastically different responses and unanticipated benefits or risks. Science and athletes should each take heed of the lessons learned by the other to better direct future research. There are benefits and risks in using AAS. Until more specific information arises, the use of these agents should be monitored closely by health care professionals. Certainly, there are benefits to individuals and society in treating the relatively common androgen deficiency seen in adult males. Whereas testosterone replacement therapy will likely remain the cornerstone of such therapy, there is likely a place for the directed use of specific AAS, such as 19-nortestosterone. Recreational users and those involved in sports doping should approach the decision to use AAS with appropriate caution from a health point-of-view, recognizing also the social and legal consequences of illicit use.
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Getbig V
Posts: 5661
Re: AAS Studies/Links/Literature
Reply #119 on:
January 30, 2009, 11:52:53 AM »
1. Kadi F. Cellular and molecular mechanisms responsible for the action of testosterone on human skeletal muscle. A basis for illegal performance enhancement. Br J Pharmacol, 2008;15:522-8.
2. Araujo AB, Esche GR, et al. Prevalence of symptomatic androgen deficiency in men. J Clin Endocrinol Metab, 2007;92:4241-7.
3. Kalyani RR, Dobs AS. Androgen deficiency, diabetes, and the Metabolic Syndrome in men. Curr Opin Endocrinol Diabetes Obes, 2007;14:226-34.
4. Laughlin GA, Barrett-Connor E, et al. Low serum testosterone and mortality in older men. J Clin Endocrinol Metab, 2008;93:68-75.
5. Kicman AT. Pharmacology of anabolic steroids. Br J Pharmacol, 2008;154:502-21.
6. Gao W, Dalton JT. Ockham's razor and selective androgen receptor modulators (SARMs): are we overlooking the role of 5alpha-reductase? Mol Interv, 2007;7:10-3.
7. Thigpen AE, Silver RI, et al. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest, 1993;92:903-10.
8. Larionov AA, Vasyliev DA, et al. Aromatase in skeletal muscle. J Steroid Biochem Mol Biol, 2003;84:485-92.
9. Weigel NL, Moore NL. Steroid receptor phosphorylation: a key modulator of multiple receptor functions. Mol Endocrinol, 2007;21:2311-9.
10. Foradori CD, Weiser MJ, et al. Non-genomic actions of androgens. Front Neuroendocrinol, 2008;29:169-81.
11. Rahman F, Christian HC. Non-classical actions of testosterone: an update. Trends Endocrinol Metab, 2007;18:371-8.
12. James PJ, Nyby JG, et al. Sexually stimulated testosterone release in male mice (Mus musculus): roles of genotype and sexual arousal. Horm Behav, 2006;50:424-31.
13. Nyby JG. Reflexive testosterone release: a model system for studying the nongenomic effects of testosterone upon male behavior. Front Neuroendocrinol, 2008;29:199-210.
14. Bancroft J, Janssen E, et al. Sexual activity and risk taking in young heterosexual men: the relevance of sexual arousability, mood, and sensation seeking. J Sex Res, 2004;41:181-92.
15. Knutson B, Wimmer GE, et al. Nucleus accumbens activation mediates the influence of reward cues on financial risk taking. Neuroreport, 2008;19:509-13.
16. James PJ, Nyby JG. Testosterone rapidly affects the expression of copulatory behavior in house mice (Mus musculus). Physiol Behav, 2002;75:287-94.
17. Urhausen A, Gabriel H, et al. Blood hormones as markers of training stress and overtraining. Sports Med, 1995;20:251-76.
18. Letendre L, Scott M, et al. Evaluating barriers to bioavailability in vivo: validation of a technique for separately assessing gastrointestinal absorption and hepatic extraction. Pharm Res, 2004;21:1457-62.
19. Welder AA, Robertson JW, et al. Toxic effects of anabolic-androgenic steroids in primary rat hepatic cell cultures. J Pharmacol Toxicol Methods, 1995;33:187-95.
20. Ohebshalom M, Mulhall JP. Transdermal and topical pharmacotherapy for male sexual dysfunction. Expert Opin Drug Deliv, 2005;2:115-20.
21. Topic B, Tavares MC, et al. Prolonged effects of intra-nasally administered testosterone on proceptive behavior in female capuchin monkeys (Cebus apella). Behav Brain Res, 2007;179:60-8.
22. Toth M, Zakar T. Relative binding affinities of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor and to other androgen-binding proteins: a suggested role of 5 alpha-reductive steroid metabolism in the dissociation of "myotropic" and "androgenic" activities of 19-nortestosterone. J Steroid Biochem, 1982;17:653-60.
23. Allen DL, Roy RR, et al. Myonuclear domains in muscle adaptation and disease. Muscle Nerve, 1999;22:1350-60.
24. Bhasin S, Taylor WE, et al. The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action. J Gerontol A Biol Sci Med Sci, 2003;58:M1103-10.
25. Meyer R, Wolf SS, et al. PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. J Steroid Biochem Mol Biol,2007;107:1-14.
26. Obendorf M, Meyer R, et al. FoxG1, a member of the forkhead family, is a corepressor of the androgen receptor. J Steroid Biochem Mol Biol, 2007;104:195-207.
27. Davison SL, Bell R. Androgen physiology. Semin Reprod Med, 2006;24:71-7.
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Getbig V
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Bless me please, father.....
Re: AAS Studies/Links/Literature
Reply #120 on:
February 04, 2009, 02:12:13 PM »
Quote from: Emmortal on January 30, 2009, 11:50:06 AM
Good read, grabbed from another board:
The Pharmacology Of Anabolic Steroids
Written by By Dan Gwartney, MD
Wednesday, 28 January 2009
Good Read, Emmortal.
I'm going to make this a sticky.
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I'm a ghost in these killing fields...
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text: This is a basic question so here goes. I'm trying to perform a logic operation on a string (an if statement on a persons name). I've tried with quotation marks "if (name == "Joe")" and with apostrophes "if (name == 'Joe')" but neither seems to work. Name is declared as "char name[25]." The statement with quotation marks it thinks even if I type the name right it is false. With apostrophes I get a "warning: multi-character character constant" error. Since I don't know anything I don't know where to start looking for answers. I've tried getting the string with "cin" and "cin.getline" but both give the same results. Also is there a way to make this statement not caps sensative, so "joe", "Joe", or "JOe" all end up being true in the statement?


text:
Journal Article
Design Challenges in the Development of a Large Vehicle Inertial Measurement System
The (Vehicle Inertia Parameter Evaluation Rig) VIPER II is a full vehicle mass and inertia parameter measurement machine. The VIPER II expands upon the capabilities of its predecessor and is capable of measuring vehicles with a mass of up to 45,360 kg (100,000 lb), an increase in capacity of 18,100 kg (40,000 lb). The VIPER II also exceeds its predecessor in both the length and width of vehicles it can measure. The VIPER II's maximum vehicle width is 381 cm (150 in) an increase of 76 cm (30 in) and maximum distance from the vehicle CG to the outer most axle is 648 cm (255 in) an additional 152 cm (60 in) The VIPER II is capable of performing measurements including vehicle CG height, pitch, roll, and yaw moments of inertia and the roll/yaw cross product of inertia. While being able to measure both heavier and larger vehicles, the VIPER II is designed to maintain a maximum error of 3% for all inertia measurements and 1% for CG height.


text:
City of Hope
City of Hope, a NCI-designated Comprehensive Cancer Center
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City of Hope, An NCI-designated Comprehensive Cancer Center, is an innovative biomedical research, treatment and educational institution dedicated to the prevention and cure of cancer and other life-threatening illness.
City of Hope has been named one of
"America's Best Hospitals"
in cancer and gynecology by U.S. News & World Report. Read more
The National Comprehensive Cancer Network (NCCN), a not-for-profit alliance of 21 of the world's leading cancer centers, is dedicated to improving the quality and effectiveness of care provided to patients with cancer.
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text:
Ethan Woodruff, MathWorks
Based on modern application areas such as power electronics and motor control, this webinar will introduce Rapid Control Prototyping (RCP). We will use Simulink Real-Time, HDL Coder and advanced FPGA target hardware and CPU to perform rapid control prototyping.
We will demonstrate how you can go beyond software-only simulation, to quickly and efficiently test your Simulink control designs in real time while connecting to hardware. We'll look closely at a brushless motor control example and demonstrate power electronics rapid prototyping using Simulink Real-Time with Speedgoat hardware. You will see how a controls or test engineer can easily configure and run the controller algorithm on a real-time target computer and communicate through high-speed I/O interfaces to power electronics, sensors, and the motor. The new Speedgoat Mobile real-time target machine, leveraging CPU and FPGA subsystem technology, is used for controller prototyping with Simulink Real-Time.
The techniques shown during this presentation cross over into many applications where you are trying to develop high quality software algorithms quickly that will eventually be embedded into a product.
Highlights of the webinar include:
Recorded: 14 Jul 2015