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PITTSBURGH, May 9 - Four years after they discovered the viral roots of a rare skin cancer, researchers at the University of Pittsburgh Cancer Institute (UPCI) and the School of Medicine have now identified a molecule activated by this virus that, in animal studies, could be targeted to selectively kill the tumor cells. The treatment will soon be tested in patients.
Merkel cell carcinoma (MCC), a skin cancer that is more common among seniors and those with weakened immune systems, could not be readily diagnosed at one time, and it still has a very poor prognosis, said Patrick S. Moore, M.D., M.P.H., and Yuan Chang, M.D., both of the Cancer Virology Program at UPCI and senior authors of a study that appears online today in Science Translational Medicine.
"This research effort shows the speed at which genomics can identify molecular causes for cancer and then point the way toward a rational and targeted treatment," Dr. Moore noted. "Since the inception of the 1971 U.S. National Cancer Act, researchers have strived to discover the underlying problems that trigger tumor development."
In 2008, the team first described the new Merkel cell polyomavirus (MCV) in Merkel cell carcinoma. Within a year, they showed it was responsible for tumor development in most cases of the disease. At least four out of five healthy adults world-wide are infected with MCV, which usually doesn't cause any symptoms.
"The virus remains in the skin cells, and in most cases, no damage is done," Dr. Chang said. "But when mutations occur to this virus, it can cause cancer. Most of the 1,500 new MCC cases per year in the U.S. are caused by MCV infection."
In quick succession, the team devised tests to identify virus-induced MCC, and began unraveling the biochemical pathways that encourage tumor formation. In their latest project, they "knocked out" a key viral protein called T antigen and found that MCV directly elevates a cellular protein called survivin.
Survivin prevents cells from dying and supports cell division, the researchers said. They found that a drug called YM155, which turns off the survivin gene again, was an extremely potent killer of MCC cells in test tubes and was able to suppress the growth of human tumors that had been established in experimental mice. In comparison, 1,360 other drugs--including most of the common chemotherapy drugs--were screened and failed to both kill MCC cells and prevent tumor growth at levels commonly achieved in patients. One of these drugs was able to kill tumor cells in culture dishes, but made no impact on the MCC tumors in mice. It remains a promising candidate drug since it may have better activity in people and is readily available.
A multicenter clinical trial of YM155, a still-experimental anti-cancer drug that is made by Deerfield, Ill.-based Astellas, is expected to begin in the next six months to determine its effectiveness in MCC patients. The trial will be led locally by Pitt School of Medicine assistant professor Hussein Tawbi, M.D., Ph.D., and professor John Kirkwood, M.D., who also is co-leader of the UPCI Melanoma Program, through the Eastern Cooperative Oncology Group, a multicenter cooperative group supported by the National Cancer Institute (NCI), part of the National Institutes of Health.
Typically, neither the cause of a cancer nor the target for a cancer drug is initially known, so most treatments have developed over decades through trial-and-error. Most therapies affect both healthy tissues and cancer cells, resulting in side effects that limit the drug dose that can safely be given. This study, in contrast, was a "rational" drug study where the underlying cellular defect caused by the virus was first discovered through genetic studies and then a drug targeting this process was tested. Survivin is needed during fetal development, but not in healthy adult cells, and YM155 was not toxic to the mice.
"Scientists can now quickly come up with answers to complex problems, like cancer, using human genetics," Dr. Moore noted. "In less than five years, we have gone from knowing very little about MCC to knowing its exact cause and are devising new, precisely targeted and less-toxic therapies."
Dr. Moore also is a Distinguished Professor and American Cancer Society Professor, Department of Microbiology and Molecular Genetics. Dr. Chang also is a Distinguished Professor and American Cancer Society Professor, Department of Pathology. Last week, they were elected to membership in the prestigious National Academy of Sciences. Prior to their work on MCV, the Chang and Moore lab team discovered another virus, a new human herpesvirus, in 1994 that causes Kaposi's sarcoma, the most common cancer among AIDS patients.
Co-authors include Reety Arora, Masahiro Shuda, Ph.D., Anna Guastafierro, Huichen Feng, Ph.D., Tuna Toptan, Ph.D., Yanis Tolstov, Ph.D., Daniel Normolle, Ph.D., Laura L. Vollmer, Andreas Vogt, Ph.D., Alexander Dömling, Ph.D., and Jeffrey L. Brodsky, Ph.D., all of the University of Pittsburgh.
The research was funded by NCI grants CA78039, CA136363, CA120726 and P30CA047904, and the American Cancer Society. The authors declare that no funding from Astellas or other companies was used for this study.
About UPCI
As the only NCI-designated comprehensive cancer center in western Pennsylvania, UPCI is a recognized leader in providing innovative cancer prevention, detection, diagnosis, and treatment; bio-medical research; compassionate patient care and support; and community-based outreach services. UPCI investigators are world-renowned for their work in clinical and basic cancer research.
About the University of Pittsburgh School of Medicine
As one of the nation's leading academic centers for biomedical research, the University of Pittsburgh School of Medicine integrates advanced technology with basic science across a broad range of disciplines in a continuous quest to harness the power of new knowledge and improve the human condition. Driven mainly by the School of Medicine and its affiliates, Pitt has ranked among the top 10 recipients of funding from the National Institutes of Health since 1997.
Likewise, the School of Medicine is equally committed to advancing the quality and strength of its medical and graduate education programs, for which it is recognized as an innovative leader, and to training highly skilled, compassionate clinicians and creative scientists well-equipped to engage in world-class research. The School of Medicine is the academic partner of UPMC, which has collaborated with the University to raise the standard of medical excellence in Pittsburgh and to position health care as a driving force behind the region's economy. For more information about the School of Medicine, see www.medschool.pitt.edu.


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Craig Bailey necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 67 diseños de 20 diseñadores freelance.
Logo - for use online and in printed material - for a Getting Organized web site and product.
Get Organized Wizard
Get Organized Wizard is a tool/system/process for organizing your life.
It's broad, spanning many life areas across work and home, and deep, going into the nitty gritty.
Unlike How-To books it doesn't just tell you what to do;
it actually takes you by the hand and guides you through the steps.
The word 'Wizard' is meant to evoke the fill-in-the-blanks simplicity and ease of software wizards.
Regarding feedback:
I will be meeting with my client daily to discuss designs that are presented. Thus, my feedback won't be immediate, but will be provided at least once a day.
- The logo should include an evocative image plus the words 'Get Organized Wizard', most likely without spaces eg GetOrganizedWizard.
- A variation that has .com appended (ie GetOrganizedWizard.com) is also required.
- Both should have a smaller tag-line underneath with the phrase (hypens and capitals exactly as): The Step-by-Step System for Taking Charge of Your Life
- There is a very basic existing text only logo at the bottom of the test site here: http://www.GetOrganizedWizard.com my client wishes to replace this with a much more engaging design.
- The logo should be:
• Clean
• Simple
• Modern
• Fun
• Have a sense of personality
• Work with the current product images - the following links are some of the current product images:
- http://www.istockphoto.com/file_clo…id=5045172
- http://www.istockphoto.com/file_clo…id=5254720
- http://www.istockphoto.com/file_clo…id=5045086
- http://www.istockphoto.com/file_clo…id=2650926
- (NB This product targets women, but as future products will target men the logo has to appeal to both)
- There are no other products like this, so it would be helpful if the logo gave a sense or hint of what the product is.
- Logo in vector format as well as some quick samples in GIF or JPG format
- Removed: Cliched images like a tick box
- In the initial brief I said I did not want any tick box or checkbox designs - however my client has asked me to allow this now.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.

subset: commoncrawl


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...at your next small group meeting!
No quiz today. But if you have some other great ice breaker questions not to use during your small group meeting, let me have them in the comment section. No googling! lol
13. Are you an infra or supralapsarianist?
12. Please quote the longest Bible verse you have memorized.
11. If you could change one thing about your spouse, what would you want to change?
10. What is the biggest satanic stronghold in your life right now?
9. What is one secret you have never told your spouse?
8. Tell us about the time in your life when you felt like a big loser.
7. What event in King David's life can you relate to the most?
6. What is the one thing you would like to change about the person to your right?
5. What is the worst name you have ever been called?
4. Turn to the person on your left and tell us how he or she could be a better parent.
3. Name a sin of someone in the room so we can pray for that person.
2. What bit of juicy gossip have you heard this week?
And the number one ice breaker you do not want to use at your next small group meeting:
1. What do you hate about our pastor?
Here are some links to other T13s.
Get the Thursday Thirteen code here!
The purpose of the meme is to get to know everyone who participates a little bit better every Thursday. Visiting fellow Thirteeners is encouraged! If you participate, leave the link to your Thirteen in others comments. It's easy, and fun! Be sure to update your Thirteen with links that are left for you, as well! I will link to everyone who participates and leaves a link to their 13 things. Trackbacks, pings, comment links accepted!
View More Thursday Thirteen Participants


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Bruder Horse trailer incl. 1 horse 1 16 Scale model With Horse
PITKIN COUNTY – This summer in Aspen, you'll still see the typical hikers, bikers and horseback riders. But one thing you'll likely see far less of is unlicensed, off-road all-terrain vehicles (ATVs) and off-highway vehicles (OHVs), as Pitkin County works to more strictly enforce its ban on such vehicles. The...
Rockies get swept by Giants after losing second game of doubleheader
Colorado Rapids fall, 3-0, at home to Premier League power Arsenal
Juvenile fires gun at Deer Creek Middle School building, 3 juveniles in custody
Avalanche podcast: Colorado signs Andre Burakovsky and what's Mikko Rantanen's worth?
Britains 1 32 New Holland Replica T6.180 Tractor Collectable Farm Toy
Trump digs in on racist tweets: "Many people agree with me"
Longmont man accused of assaulting, running over woman near Gordon Gulch in Boulder County
Trump abortion restrictions effective immediately
Gas line blast levels house in California, kills one and injures 15
A utility worker was killed and 15 other people were injured on Monday when a ruptured gas line triggered an explosion that leveled a house and shattered windows in nearby homes in the Southern California town of Murrieta, authorities said.
One dead, 15 injured in gas line blast that levels house in California
Guggenheim defeats lawsuit claiming it siphoned annuity unit's cash for LA Dodgers
Britains Land Rover Defender 90 With Ifor Williams Canopy 1 32 42101
With political power at stake, North Carolina gerrymandering trial begins
Minichamps 1 18 Hanomag R28 Tractor in orange - Brand New
Facing new asylum curb, nerves for those waiting at U.S.-Mexico border
Papua New Guinea Prime Minister James Marape will make a state visit to Australia, its government said on Tuesday, as it seeks to cement its position with Pacific island's new leader amid rising competition for influence in the region.


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Maintained by: The LDraw.org Standards Committee
Author: The LDraw.org Standards Committee
Writers: Steve Bliss, Travis Cobbs, William Howard
Contributers: Jacob Sparre Andersen, Rui Manuel Silva Martins, Gary Williams, Lars C. Hassing
Revision: 1, 09-Nov-2006
Back Face Culling (BFC) file format extension
To establish a standard for back face culling processing in LDraw-compatible rendering programs. This standard will include language extensions, definitions and expected processing effects.
In this document this standard will be called the BFC extension.
The standard must allow cross-compatible LDraw files. That is, LDraw-compatible rendering programs that don't support the BFC extension must render BFC-enabled LDraw files correctly, while renderers that support the BFC extensions must render non-BFC'ed LDraw files correctly.
To make this standard useful and effective, the LDraw parts library must be updated to follow the new standard. Since it would be difficult to rewrite the entire library in one update, the standard will allow for a mix of BFC enabled and non-enabled files in one rendering.
Certified. An LDraw file is certified if it complies with the specifications in this document, includes a 0 BFC CERTIFY meta-statement before the first operational command-line, and does not contain a 0 BFC NOCERTIFY meta-statement.
Clipping. In this document, the term clipping is used as a synonym for culling. While this is technically incorrect, the usage is kept for backwards compatibility with the prior draft and de-facto standards. (In other graphic contexts, clipping usually refers to trimming a geometric primitive to not extend past the edge of a given region, while culling refers to not drawing the primitive at all.)
Culling. In this document, the term culling refers to the process of performing back face culling; that is, not drawing a geometric primitive at all.
File-reference Branch. A set of files in the file-reference tree that either start from the main model file or from a part file. The file-reference tree has a single main branch (the main model) which contains many sub-branches (the parts) which themselves may contain sub-branches (for example, a complete assembly such as a minifig).
Invert. Turning a subfile inside out, usually performed on geometric primitives. When back face culling is used inversion is needed or interior surfaces will never be rendered. Because polygons are one-sided, interior primitives need to have their surfaces face inward, rather than outward.
LDraw file. A single file specifying a part, sub-part, primitive or model. Parts, sub-parts and primitives have the extension DAT, while models can use DAT, LDR or MPD. While BFC meta-statements are rarely used in model files, they still apply, and should be used if the model file contains any polygons.
Operational Command-Line. Any statement in an LDraw file with line-type 1 through 5. In other words, the Subfile, Line, Triangle, Quad, and Conditional Line statements.
Part. An LDraw file which represents a complete real-world building element. These files are stored in the ldraw\parts\ directory.
Polygon. A 2D surface created by LDraw's line-type 3 (triangle) or 4 (quadrilateral) command.
Primitive. An LDraw file, typically small, which models a geometric shape or a standard attribute of building elements, such as studs or the cross-axle shape. These files are kept in the ldraw\p\ directory (for lo-res primitives) and the ldraw\p\48 directory (for hi-res primitives). (In other graphics contexts, the term primitive refers to the basic geometric shapes provided by the rendering environment.)
Subfile. An LDraw file referenced from another file, via a line-type 1 command. Or any file which is lower in the file-reference branch than the current file.
Subpart. An LDraw file which is only a portion of a complete element. It does not necessarily correspond to a discrete portion of a real-world building element. These files are kept in the ldraw\parts\s\ directory.
Superfile. The file which referenced the current file. More generally, any file which is higher in the current file-reference branch than the current file.
Winding. This is the order vertices are specified in a polygon command. The order can be either clockwise or counter-clockwise (AKA anti-clockwise), and is based on viewing the polygon from its front side.
Clockwise winding (vertices numbered 0 through 3):
0 -> 1
^ |
| v
3 <- 2
Counter-clockwise winding:
0 <- 3
| ^
v |
1 -> 2
The BFC language extension allows LDraw files to specify and control the following conditions:
Compliance. LDraw files which follow the BFC extension must be clearly and unambiguously marked. It is also useful to allow non-compliant files to be marked as well. Having the compliancy stated plainly simplifies the task of the rendering program, and makes it easier for humans to read files.
Marking a file as BFC-compliant only directly affects that file. In order for subfiles to be treated as compliant, they must also be marked as compliant. Additionally, with the exception of parts, a file is only treated as being BFC-compliant if it and all of its superfiles are compliant. The reason for this is that, while processing, there is no way to know the intended inversion state of a subfile when the file's superfile isn't BFC-compliant. The reason that part files can be excepted from this rule is that they are complex closed solids, so there is never a valid reason to invert them. Assuming part files are never inverted allows the rendering engine to apply BFC-processing on certified parts, even if the calling file(s) (for example, the main model file or sub-models of the main model) aren't certified.
Winding. It must be possible for a file to specify the winding order of the polygon commands within that file: clockwise, counterclockwise, or unknown. Allowing the winding to be set at the file level (as part of the 0 BFC CERTIFY meta-statement) is primarily a convenience for file authors.
Changing the winding setting will only affect the current file. It will not modify the winding of subfiles.
It is permitted to change the winding of polygons within a file. In this case the change of winding direction affects all polygons following the CW/CCW option, either until the end of the current file or another CW/CCW option is encountered.
Culling. It must be possible to enable and disable culling during the processing of a file. But even when culling is currently enabled, it may not be possible to actually cull the polygons. Polygons can be tested for culling only when the following conditions apply:
* All superfiles (in the current file-reference branch) are certified
* The current file is certified
* No superfile has disabled culling prior to referencing this subfile
Unless all of these conditions are met at the time a subfile is rendered, no culling is possible.
If the culling state is modified, it affects all lines following the CLIP/NOCLIP option, either until the end of the current file or another CLIP/NOCLIP option is encountered. When subfiles are referenced, they will receive a flag indicating the accumulated culling state, but there is no sense of a global culling mode.
Inversion. Sometimes, it is desireable to reverse the surfaces of a subfile; to turn the subfile 'inside out'.
One common example of inversion is the cylinder primitive. Cylinder primitives are designed so the surfaces face outward from the center. In 3D tubes, a pair of cylinder primitives are used to model the tube; one outer cylinder is oriented normally, and the inside cylinder, scaled slightly smaller, is required to face inward. This is accomplished by flagging the inner cylinder as being inverted.
Inversion accumulates down the file-reference branch. If the current file is being rendered inverted, then any subfiles of the current file are also rendered as inverted.
Inversion is a boolean operation; inverting a file that is already inverted will give the file the normal orientation. So if the current file is inverted, and a subfile is flagged as inverted, the subfile will be rendered with normal orientation, that is, right-side-out.
(As a practical matter, rendering engines can accomplish inversion simply by switching the order of winding; treat CCW files as CW and vice versa. This must happen in conjunction with the other settings.)
There is a single meta-statement in the BFC language extension, the 0 BFC statement. The statement includes options to specify BFC-related operations.
where (a | b) means either a or b, [] indicates optional items and {} indicates the default value.
This syntax results in the following permissable variations of the BFC meta-statement
0 BFC CERTIFY (CCW is implied)
0 BFC CLIP (winding is unchanged)
The BFC meta-statement and all of its options are case-sensitive, ie, they must always be in all capitals.
The BFC meta-statement shall ignore repeating whitespace, and accept any number of spaces or tabs as equivalent to a single space.
In order for a file to be processed with back face culling, there must be at least one 0 BFC meta-statement before the first operational command-line. If there is no such 0 BFC meta-statement in the file, BFC processing will be disabled for that file.
Only one NOCERTIFY/CERTIFY meta-statement may be present in a file, and if present, must preceed all other BFC meta-statements and operational command-lines.
All BFC commands that act on succeeding lines in the file shall ignore empty lines.
For backwards compatibility the CLIP and winding options may be specified in any order on the meta-statement, so the following are also valid
This option indicates the LDraw file is compatible with the back face culling extension. Every LDraw file must be clearly labeled if it is compliant. One way to accomplish this is to place 0 BFC CERTIFY at the beginning of the file, before the first operational command-line.
A second way to specify a file as compliant is to use any option, except for NOCERTIFY, on a 0 BFC meta-statement, before the first operational command-line. This is an acceptable alternative, but the 0 BFC CERTIFY method is recommended and prefered.
Files in the LDraw.org Parts Library, if they are BFC compliant, are required to have an explicit 0 BFC CERTIFY line in their header.
If a file has no 0 BFC meta-statement before the first operational command-line, 0 BFC NOCERTIFY is assumed and BFC processing will be disabled for the file.
This option specifies that the file is not compliant with the BFC specification; the polygons are not wound consistently and/or correctly, and/or subfile references are not properly inverted. If the NOCERTIFY option is used, it must appear before any operational command-lines. Any other BFC meta-statements in the file will be ignored.
This option sets the cull-state to enabled. This allows culling, if all other conditions for culling are met. (While this option should be called CULL, the CLIP form is intentionally being kept for backwards compatibility.)
This option sets the cull-state to disabled. Any subpart or primitive referenced while the cull-state is disabled will not be eligible for culling. (While this option should be called NOCULL, the NOCLIP form is intentionally being kept for backwards compatibility.)
CLIP/NOCLIP Notes
There may be any number of changes to the cull-state in a file, although it is recommended that such changes be kept to a minimum.
If neither the CLIP nor NOCLIP option is specified on a 0 BFC meta-statement before the first operational command-line, then that file's cull-state is set to enabled (CLIP).
This option sets polygon winding to clockwise.
This option sets polygon winding to counter-clockwise.
CW/CCW Notes
There may be any number of changes to the winding direction in a file, although it is recommended that changes to winding are kept to a minimum.
If no winding option is specified for a file, the local winding state will be defaulted to counter-clockwise (CCW).
This option inverts a subpart or primitive. It may only be used immediately before a subfile command line [while intervening blank lines are permitted, they are discouraged for reasons of readability], and it only influences the immediately following subfile command. It should never be used before a part.
1 16 0 0 0 1 0 0 0 1 0 0 0 1 somefile.dat
1 16 0 0 0 1 0 0 0 1 0 0 0 1 another.dat
In this example, somefile.dat would be rendered as inverted while another.dat would not be inverted.
For further information, see "Inversion" in the Language Extension Functionality section.
(This section gives some suggestions for implementing BFC within the LDraw Parts Library and the impact on the current library. This section may be varied by other specifications (for example, the Parts Library Header specification) and/or the requirements of the Parts Library administrators without affecting the validity of the Back Face Culling specification.)
The LDraw Parts Library includes all parts, primitives, and subparts distributed with LDraw or in an ldraw.org parts update.
New parts will not be required to be compliant with this extension. They will however be required to carry a 0 BFC meta-statement, indicating either compliance or non-compliance.
New primitives will be required to be certified before being accepted for release.
It is desirable for all files to use the same winding. When possible, files should use counter-clockwise winding. The actual winding for any part is left to the file author. Primitives should always use CCW winding.
Primitives should generally be written so that polygons face outward, or upward. Exceptions are allowed for polygons which model inward- or downward-facing surfaces.
As noted in the language sections, all BFC compliant files in the parts library will have an explicit 0 BFC CERTIFY line in their header.
(This section gives some suggestions for the design of programs in order to achieve correct renderings. Any program may violate these guidelines if there is another way to achieve a valid rendering.)
Matrix Reversals. Rendering engines will need to correct for orientation matrices which inadvertently or deliberately reverse a subfile.
Normal transformation:
1 16 0 0 0 1 0 0 0 1 0 0 0 1 somefile.dat
'Reversed' transformation:
1 16 0 0 0 1 0 0 0 -1 0 0 0 1 somefile.dat
If the rendering engine does not detect and adjust for reversed matrices, the winding of all polygons in the subfile will be switched, causing the subfile to be rendered incorrectly.
The typical method of determining that an orientation matrix is reversed is to calculate the determinant of the matrix. If the determinant is negative, then the matrix has been reversed.
The typical way to adjust for matrix reversals is to switch the expected winding of the polygon vertices. That is, if the file specifies the winding as CW and the orientation matrix is reversed, the rendering program would proceed as if the winding is CCW.
The INVERTNEXT option also reverses the winding of the polygons within the subpart or primitive. If the matrix applied to the subpart or primitive has itself been reversed the INVERTNEXT processing is done IN ADDITION TO the automatic inversion - the two effectively cancelling each other out.
Inverted Subfiles. Generally, it is not possible to determine that a subfile reference is inverted or normal (which is the reason for the 0 BFC INVERTNEXT meta-statement). In particular, the rendering engine should *not* use the determinant of the orientation matrix to determine if the subfile is intended to be inverted (see 'Matrix Reversals', above).
Note: Part files are never inverted as they represent closed solids.
Uncertified Files. No assumptions can be made about models which make direct use of primitives or polygon commands, so a rendering engine should not simply treat uncertified model files as certified.
Culling State. The rendering engine can default to either allow or disable culling at the start of processing. Presumably, the user will be given the ability to control this state.
Degenerate Matrices. Some orientation matrices do not allow calculation of a determinate. This calculation is central to BFC processing. If an orientation matrix for a subfile is degenerate, then culling will not be possible for that subfile.
(This section presents a possible model for writing the core processing loop in an LDraw/BFC rendering program. Any program may violate this model if there is another way to achieve a valid rendering.)
All BFC-relevant logic is included while as much other logic (as possible) is excluded. It should not be assumed that this pseudo-code represents the most effecient way to implement BFC.
The function BFC() returns a boolean value, indicating whether a polygon should be rendered or culled. As the nature of this routine does not impact the BFC standard, the logic for BFC() is not included in the following pseudo-code. There is information about BFC processing available from many locations, including lugnet.cad.dev
Recursive Procedure RenderFile Parameters: ModelFile string // File to render AccumCull boolean // global culling value yes/no AccumInvert boolean // current inversion normal/inverted AccumTransformMatrix matrix // current transformation Colour integer // current colour Declare LocalCull boolean Initial TRUE Winding bivalue(CCW, CW) Initial CCW Certified trivalue(TRUE, FALSE, UNKNOWN) Initial UNKNOWN InvertNext boolean Initial FALSE Command DATCommandLine // Structure containing parameters from // a single operational command-line. OpenFile(ModelFile) Do Until EOF(ModelFile) Get Next Command If Command.Colour = 16 Then Command.Colour = Colour ElseIf Command.Colour = 24 Then Command.Colour = EdgeColour(Colour) End If Case Command.LineType BFC If Certified is UNKNOWN and no Option in Command is NOCERTIFY Then Certified = TRUE End If Do for each Option in Command Case Option CERTIFY Assert Certified != FALSE // Triggers error if file has been NOCERTIFY'ed Certified = TRUE NOCERTIFY Assert Certified != TRUE // Triggers error if file has been CERTIFY'ed Certified = FALSE CLIP: LocalCull = TRUE NOCLIP: LocalCull = FALSE CCW If AccumInvert Then Winding = CW Else Winding = CCW CW If AccumInvert Then Winding = CCW Else Winding = CW INVERTNEXT InvertNext = TRUE End Case End Do SUBFILE If Certified is UNKNOWN Then Certified = FALSE Case Certified TRUE RenderFile Command.Subfile, (AccumCull and LocalCull), (AccumInvert xor InvertNext), Command.TransformMatrix * AccumTransformMatrix, Command.Colour FALSE, UNKNOWN RenderFile Command.Subfile, FALSE, (AccumInvert xor InvertNext), Command.TransformMatrix * AccumTransformMatrix, Command.Colour LINE, CONDITIONAL_LINE If Certified is UNKNOWN Then Certified = FALSE Deal with primitive command TRIANGLE, QUAD If Certified is UNKNOWN Then Certified = FALSE End If If AccumCull and LocalCull And (Certified is TRUE) Then If BFC(Command, AccumTransformMatrix, Winding) Then Render Command Else Don't render Command Else Render Command End If End Case If Command.LineType != BFC Then InvertNext = FALSE ElseIf No Option in Command is INVERTNEXT Then InvertNext = FALSE End If Loop End Procedure


text:
Are Jude Law and Sienna Miller getting back together?
That's what many are wondering after the couple reportedly met up for a handful of dinner dates in New York City, according to OK! Magazine's U.K. edition.
VIEW THE PHOTOS: The Brit Pack: Hot Shots Of Stars From The U.K.!
Both Jude and Sienna are starring on Broadway in separate productions – Jude is in "Hamlet," Sienna in "After Miss Julie."
"Sienna and Jude have met up a few times and got on really well," a source told the mag.
VIEW THE PHOTOS: Sienna Miller
Jude and Sienna began dating in 2004 and ended things in 2006.
Jude reportedly broke Sienna's heart after it was revealed he cheated on her with his children's nanny.
"Sienna had her heart broken by Jude, but she was young and it was the first time she'd fallen in love," the source added. "What people don't realize is that they always remained close, so who knows where this will lead to next."
Related Content from AccessHollywood.com:
VIEW THE PHOTOS: Jude Law
PLAY IT NOW: Sienna Miller Talks 'Edge of Love' & 'G.I. Joe'
PLAY IT NOW: Jude Law Talks 'Sleuth'
MORE ACCESS ON THESE TOPICS: Sienna Miller - Jude Law - Broadway - Brits - Celebrities


text:
Cactus Coffee Table – Medium
Cactus Coffee Table - 43" x 17" x 18" high
Enjoy this one-of-a-kind artistic statement piece that enhances all decor themes.
This rare find is extremely limited, and sure to be a treasured art heirloom for anyone fortunate enough to possess one.
Medium Sizes Range from 28" to 47" diameter or oblong x 18" high
Custom Sizes Available
Table shown is an approximate representation of this table. Each table is uniquely beautiful and one-of-a-kind. Please email Natalie Scott Designs to see the exact table you will be receiving.


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In a show full of quests and magical items, it is the most special. The Enchiridion, Adventure Time's ancient and sacred tome. The iPad isn't quite as special, but this awesome cover lets you pretend it can be.
Made by HarryDumitrescu, it's built from "fake leather", drawn with a Molotow graffiti pen and then covered in a clear finish to give it that book-y look. The brackets are made of metal.
No word on whether HarryDumitrescu is dressed like an adorable little key, but let's hope.
Enchiridion [via Super Punch]


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It Is All About BTC, LTC, ETH, ZEC mining as well as other alternative crypto currencies
There were some people asking for a simple solution to automate the process of restarting a miner software every few hours in order to be sure that it is working fine under Windows OS. The below Batch file code example offers a simple and easy way to do that and it uses sandor's fork of cpuminer for Gridseed Scrypt ASICs as an example. You need to set the parameters based on the miner and command line you use as well as the time after which the miner process will be killed (default 4 hours), then the script will wait for 10 seconds and start the miner again. There is also a counter to show you the number of restarts that have been executed since you've started the Batch script.
@echo off
echo -------------------------------------------------------------------
echo Simple script to restart your miner software after a period of time
echo -------------------------------------------------------------------
set executable=minerd.exe
set commandline=--freq=1150 --gc3355=\\.\COM1 --url=stratum+tcp://eu2.multipool.us:7777 --userpass=yourworker.1:password
set runforseconds=14400
set restartinseconds=10
set /a counter=0
start "Miner Window" %executable% %commandline%
echo The software will run for %runforseconds% seconds
timeout %runforseconds%
taskkill /f /im %executable%
echo Restarting the software in %restartinseconds% seconds (%counter%)
timeout %restartinseconds%
set /a counter+=1
goto start
In order to use the code above you just have to copy it and save as a .BAT file as well as to modify some of the variables as per your needs and requirements and then run it. Do note that you will get two program windows, one that will have the Batch script running and another for the miner software. You should not close the windows with the script running as this will stop the execution of the script immediately and the miner software will not be restarted anymore.


text: UFDC Home myUFDC Home | Help | RSS <%BANNER%> Gainesville daily sun ALL ISSUES CITATION THUMBNAILS MAP IT! PAGE IMAGE ZOOMABLE Full Citation STANDARD VIEW MARC VIEW Permanent Link: http://ufdc.ufl.edu/UF00028298/00171 Material Information Title: Gainesville daily sun Uniform Title: Gainesville daily sun (Gainesville, Fla. 1903) Running title: Daily sun Alternate Title: Sun Physical Description: Newspaper Language: English Publisher: H.H. McCreary Place of Publication: Gainesville Fla Creation Date: September 18, 1908 Publication Date: -1938 Frequency: daily (except saturday)[ -1938]daily (except monday)[ former <1903>-]dailynormalized irregular Subjects Subjects / Keywords: Newspapers -- Gainesville (Fla.) ( lcsh )Newspapers -- Alachua County (Fla.) ( lcsh ) Genre: newspaper ( marcgt )newspaper ( sobekcm ) Spatial Coverage: United States -- Florida -- Alachua -- Gainesville Coordinates: 29.665245 x -82.336097 ( Place of Publication ) Notes Dates or Sequential Designation: -58th year (July 24, 1938). General Note: Description based on: Vol. 20, no. 48 (Apr. 5, 1903). Record Information Source Institution: University of Florida Rights Management: All rights reserved by the source institution and holding location. Resource Identifier: aleph - 002027051oclc - 32994415notis - AKL4641lccn - sn 95026977 System ID: UF00028298:00171 Related Items Related Items: Gainesville sun (Gainesville, Fla. : 1903) Preceded by: Daily sun (Gainesville, Fla.) Succeeded by: Alachua County news (Gainesville, Fla. : 1934) Succeeded by: Gainesville daily sun and the Alachua County news Contact Us | Permissions | Preferences | Technical Aspects | Statistics | Internal | Privacy Policy © 2004 - 2011 University of Florida George A. Smathers Libraries.All rights reserved. Acceptable Use, Copyright, and Disclaimer Statement Powered by SobekCM


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Computer Locks
Five ways to bolster computer security when you are on the move
It is widely accepted to use laptop for getting the work done when you are off the office. Yet mobile computing attract laptop lifters and they are always on the look out for their prey (people with laptops)
While losing laptop means losing easy 1000 bucks it also jeopardizes your job and gives critical personal or financial information or company details to wrong people. It also means you have also lost system configuration you have set for smooth functioning. It kind of puts you at a bigger loss than the laptop per se. However, by following the 5 tips you can keep your laptop secured even when you are mobile computing on the road.
1) Stop carrying laptop bags when you have to travel in bus or train. It kind of sends obvious signals to the lifters that you are carrying one. Use an ordinary tote to carry it otherwise or even carry in a padded briefcase.
2) If you should be taking laptop for a flight journey carry it on your person. However, carrying a suitable computer lock with you should make it convenient as you can secure it. Investing in buying computer locks or say, a laptop security device will give you lot of peace of mind. If you have to leave the system in the airport lobby or even at work, attach the computer lock cable securely to a fixed heavy object such as a desk or chair is good idea.
3) You don't want everyone to know what you've been doing in the system, do you? Computer locks with monitor cable lock should prevent shoulder surfers around to sneak peek into your laptop. The monitor cable lock just locks the screen of the laptop making it not only difficult to sneak peek but also lift it.
4) Carry laptop and passwords separately. In the sense do not have passwords and access information in the same briefcase that carries the laptop. It's like making the job of laptop thief so much easier. Should you lose the laptop at least the thief can't access personal information.
5) Encrypting the data is more of after laptop is stolen. It works as a repair and prevent the laptop lifter to gain access through your files and pick up information. Encrypting gives added protection so the information stored is not retrieved even after the laptop is stolen. With OS such as Windows XP, Vista, and the Windows 7 encrypting the files and folders is possible.
Resource Box:
Computer locks offers discounted price for schools and universities. If you want to be a reseller affiliate of computer lock products, http://www.compulocks.com offers good offers on that as well. The company is a designer and manufacturer of computer locking solutions for over 30 years. Some of the products come with life time replacement warranty and orders over $99 are shipped for free within US and Canada. The company has earned quite a lot of reputation in the computer security solutions industry.
About Compulocks Group
Compulocks Group has been a premier designer and manufacturer of Computer Locking solutions Since 1983.
We Manufucture a range of Laptop Locks, Macbook Lock, Mac Book Lock, iMac Cable Lock, Computer Locks, Mac Locks, Mac pro Lock, Notebook Locks, Apple Locks, Mac Lock, iMac Lock , mac Mini Lock , computer lock , laptop lock , pc lock and other computer cable locks and Computer Enclosure Devices.
Among the group companies are: MacLocks , NotebookCarts , LaptopLocks , Compulocks and PcLocks
Our Computer Locks, Laptop Carts and other Security Solutions are sold to Corporations accounts, Educational institutes, State and National Government Agencies, resellers and distributors World Wide and are all sold w
life time Replacement warranty.
Compulocks Group has been working with our Customers and Partners to solve their security issues, using innovation, the highest quality of materials, integrity and commitment to the highest level of customer service.
We own a large number of pattens in the field of Hardware Security and spend a lots of resources in Research and Development and in the Quality control of our products.


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NCRF holds annual fundraising phone-a-thon
Local court reporting firm owner Jan Ballman joined peers in calls for donations
VIENNA, Va. —The National Court Reporters Foundation (NCRF), the charitable arm of the National Court Reporters Association (NCRA), the country's leading organization representing stenographic court reporters and captioners, today announced that Jan Ballman, a court reporting firm owner from Minneapolis, Minn., and NCRF secretary/treasurer, served as one of this year's volunteers to help raise donations that will be used to fund many of the Foundation's programs.
This year's annual event brought together eight volunteers from the NCRA membership at its headquarters in Vienna, Va., where they made more than 3,000 phone calls to colleagues over three days. The annual phone-a-thon is one of the Foundation's largest fundraising events and typically raises more than $50,000 each year.
Ballman was joined by: Bonnie Shuttleworth, a court reporting instructor from Crestwood, Ill.; Cecilee Wilson, a captioner and CART provider from Kaysville, Utah; Teresa Kordick, a court reporter from Des Moines, Iowa; Jackie Timmons, a court reporter from Darien, Ill.; Sharon Fox, a court reporter from Bismarck, N.D.; Cathy Penniston, a captioner and CART provider from Ottumwa, Iowa; Lisa DiMonte, a court reporter from Great Falls, Va.; and Joan McQuinn, a court reporter from Rockford, Ill.
"I serve as secretary and treasurer of the Foundation so I feel personally committed to supporting its work, and I totally believe in what the Foundation does," said Ballman who was a freelance court reporter for 21 years prior to opening her own firm. She holds the professional certification of Registered Professional Reporter, (RPR), and is a three-time phone-a-thon volunteer.
"NCRF could not exist without the volunteer support we receive. It's the volunteers who raise the money for our programs," said B.J. Shorak, deputy executive director of the Foundation. "We appreciate the busy schedules that court reporters keep, so when they take precious time from work and family to help support the Foundation, it just shows the strong commitment they have to their profession."
NCRF launched its annual phone-a-thon in the mid-1990s and has relied on using member volunteers to make the calls rather than an outside company because of the high success rate of the peer-to-peer outreach, said Shorak.
"Court reporters appreciate talking to one of their own and recognize that the Foundation and its work must be important if so many volunteers annually make the trip to Vienna to staff the phones. The event also provides a wonderful networking opportunity at both ends of the receiver. Many times our volunteers are able answer questions a member might have about the Foundation, NCRA, or even the profession."
NCRF supports the court reporting and captioning professions through philanthropic activities, such as the Legal Education Program, which facilitates the education of the legal profession about the role of the court reporter through "Making the Record," a court reporter-led seminar launched in 2010 and geared toward law students, attorneys and judges. Under the Legal Education Program, NCRF has also partnered with NCRA at the biennial Court Technology Conferences, sponsored by the National Center for State Courts, to ensure court reporter technology is before key players in court administration.
NCRF's Oral Histories Program (OHP) raises public awareness about the court reporting profession by focusing on capturing and transcribing the poignant oral histories of American wartime veterans through the Library of Congress' Veterans History Project (VHP). NCRF coordinates with NCRA members to complete transcripts of the interviews and submit them to the Library of Congress. In the 10 years that NCRF has partnered with the Library's VHP, NCRA members have submitted more than 2,850 transcripts, as well as additional transcripts to other program partners, including the National Equal Justice Library at Georgetown University, Washington, D.C., the Center for Public Policy & Social Research at the Central Connecticut State University, and its latest partner, the Illinois State Library.
The Foundation also sponsors prospective court reporters through its Student Initiatives Program, which provides several scholarships and awards, including the New Professional Reporter Grant. The student program also encourages future court reporters to become involved within the profession's community by inspiring students to participate in VHP.
NCRF's CART Services Program showcases the work of Communication Access Realtime Translators by providing grants to consumer organizations, such as the Association of Late-Deafened Adults. CART providers offer live-event captioning and personalized service for the deaf and hard-of-hearing.
The Foundation also supports NCRA's participation in Intersteno to make certain the organization is able to represent the court reporting and captioning professions globally.
About NCRF
As a charitable organization, the Foundation relies almost solely on tax-deductible donations. They are our lifeblood, and we cannot exist without them. The majority of NCRF's support comes from NCRA members and associated businesses. That's why NCRF offers various giving options, from dues check-off to our phone-a-thon(s) to our annual Angels Drive to a vacation property auction. You can also support NCRF through your estate planning by becoming a member of NCRF's Legacy Society. To donate, or for information on NCRF's programs, visit www.ncra.org/ncrf, or contact Deputy Executive Director, Ms. B. J. Shorak, at
firstname.lastname@example.com, or at 800/272-6272, ext. 126.
About NCRA
The National Court Reporters Association (NCRA) is internationally recognized for promoting excellence among those who capture and convert the spoken word to text for more than 100 years. NCRA is committed to supporting its more than 19,000 members in achieving the highest level of professional expertise with educational opportunities and industry-recognized court reporting, educator and videographer certification programs. NCRA impacts legislative issues and the global marketplace through its actively involved membership. Forbes has named court reporting as one of the best career options that do not require a four-year degree, and the U.S. Bureau of Labor Statistics reports that the court reporting field is expected to grow more than 5 percent in the coming years. For more information, visit www.NCRA.org.


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The short answer is, absolutely.
An SSL certificate provides security for your customers data. Without one, their data is not protected and you will, most likely, lose customers. That is because even little old grandmothers surfing the web know that they are supposed to look for the https in the url or the image of the lock when placing orders. When they don't see either, they may go to another site. We provide two options for SSL's: shared and private. As far as security, they are the same.
The main differences are that the shared SSL is free but you cannot control the name in the url. The private SSL costs around $50/year plus a $2/month charge for the required private IP (that cost varies with the host) but you can control the name in the url. Some shop owners don't like to have the shared name show up in their url's while others don't mind. Using a shared SSL may not work with some payment modules but there are only a few of those. Otherwise it is fine to use.
Your Wishlist is empty.


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Calliah Mullen is the sister to Irene Adler and has...
Continue of Cuts153310
- by GleeWhoLock
- Rating:
- Published: 19 Jan 2015
- Updated: 16 Feb 2015
- Status: In Progress
This is the continuation of Cuts. Now that Sherlock is at home safe, what will happen to the gang? What new evils will pop up?
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My roommate Pat and I recently, for some reason, watched the final season of "The West Wing" together on Netflix, which produced a number of arguments, speculations, and asides that I have compiled in an e-mail exchange for the inaugural edition of The Markley TV Club. I realize the final season of "The West Wing" in which plucky Texas congressman Matt Santos faced off against Republican straight-talker Arnold Vinick, aired like 27 years ago or something, but so what? Y'all didn't get me and my roommate's commentary until right now.
Markley: So it seems to me we're dealing with two primary issues here, the first of which is: was the Santos/ Vinick election the most dramatic in American history? We had a screwy electoral map, the first Latino candidate, the first pro-choice Republican of the modern era and—oh yeah, that's right: a near nuclear plant meltdown that changed the dynamic of the race and a VP candidate who died on the day of the goddamn election! Makes me yawn at 2000 and 2008.
Pat: Very true. The Santos / Vinick election borrowed the best parts of 2000 and 2008 (too close to call and minority candidate), and then used a VP candidate surprise death (we're coming back to this) and nuclear meltdown in a crucial swing state (this too) to trump the excitement of every US presidential election previous combined. I applaud Vinick for not contesting the vote in Nevada unlike Gore in 2000. In fact, I think Vinick's positive, congratulatory response was key to getting the nod as Secretary of State. It makes you think. Is Sorkin (I'm going to assume he is the mastermind behind everything even though he left after season four) trying to tell us that there could have been a cabinet seat for Gore had he not whined about a recount in Florida? We'll never know.
As you mentioned though, there were plenty of surprises along the way. A pro-choice, anti-religion Republican. A closet-creationist, anti-union Democrat. California voted for a pro-nuclear candidate two weeks after a near nuclear holocaust (How did Vinick manage to sway public opinion with just a two hour press conference?). South Carolina voted Santos despite everything we know about the history of race relations.
The biggest surprise for me, even bigger than a Democrat addressing teacher performance or the shoddy campaign signs, was the classless reaction to the death of the architect of the Bartlett presidency, VP Candidate and former Chief of Staff, Leo McGarry. Without McGarry, Bartlett doesn't run for president and go on to raise minimum wage, fix social security, and achieve a Middle East peace deal. Leo was forgotten within hours despite his enormous contribution to the country. Am I the only one that's outraged by this?
Markley: Whoa whoa whoa. First of all, bro, Vinick lost Nevada by a final count of 70,000 votes. Gore "lost" Flordia by 537 officially and had the Supreme Court allowed the recount to continue with a standard that allowed ballot counters to look for the true intent of the voter, would have won. Seeing as how Gore came out immediately against the disaster that was the Iraq war, I doubt he would have done well as SecState in the Bush administration, unlike the limp coward Colin Powell, who let Bush/Cheney march to war despite his huge reservations.
At any rate, enough re-litigating the 2000 debacle. Let's focus on two things: 1) Those Santos/McGarry signs were total garbage, topped only by the Vinick/Sullivan yard signs. It looked like the four of them were running for town council in New Philadelphia, Ohio.
2) Leo was also a major drag on the Santos ticket, and never belonged there in the first place. He was a recovering alcoholic with a bad heart who clearly would have had an affair with his campaign aide had he not dropped dead. Now Santos has a major uphill battle with the Senate to confirm Pennsylvania Governor, Baker, when he should have just put him on the ticket in the first place and locked up that state. Josh Lyman fell down on that one. Some people you run for office and some people you have run a person for office. Leo McGarry belongs behind the scenes, and I can't believe Oregon's fourth district would vote for that turd-in-glasses Will Bailey.
Pat: The campaign sign graphics were as pathetic as the one used for my class president bid freshmen year of high school. But Josh Lyman has a near perfect batting average when it comes to political decisions, all without ever sleeping or combing his hair. Josh knew that the top of the ticket would carry the general election so he just needed someone that could run the country. This perhaps brings up a larger point about a line of insignificant, unimpressive vice presidents: Hoynes, a serial womanizer; Russell, a hack politician by all accounts; McGarry, a lousy campaigner; and Baker, a guy with terrible glasses. This had to have been done on purpose to showcase the dynamism of the intellectual force, Jed Bartlett and the Latin sensation Matt Santos.
And I totally agree that the Oregon fourth would not elect Will "I love khakis" Bailey. But what gets lost in the shuffle is the tragic fall of the once promising political career of Deputy National Security Advisor, Kate Harper. I have to believe that Santos left her out of his incoming staff because of her embarrassing affair with the dud Will Bailey. Is that the type of judgment you want in the Sit Room?
Markley: Wow, Pat's bid for class president. What was the platform—CVS sandwiches and fruit cups for the lunchroom?
Totally agree on the general terribleness of VPs from the Bartlett administration onward. The Democratic Party has to understand that even while they're nominating Nobel Prize winning economists and tall, dark drinks of water like Santos, they have to pay a modicum of attention to the bottom of the ticket and not just prop up the nearest warm body. Also, Will Bailey is not only a carpetbagger with terrible political instincts (supporting Bob Russell for president? Why not just go ahead and hand Vinick the election?), the fact that he bagged a babe with such impressive national security credentials is a testament to the general shittiness of male dating material in the Bartlett administration. Think about it: Toby's out, Josh is out, Leo's dead, the SecDef is a douche bag, and Charlie is sneaking out of the youngest Bartlett daughter's room at 3 a.m.
Speaking of babes: Is Helen Santos the hottest first lady in the history of the country? Should we even bother to look back through the history books or just call it a day?
Pat: First off, my laissez-faire approach to student government got me elected as class president for three consecutive terms until I lost famously senior year due to mounting voter discontent and a record low approval rating.
You bring up a good point about the scarcity of viable guys for women in the Bartlett administration. After Sam Seborn left and with Josh locked down by major babe Donna Moss, it's slim pickings for the ladies (Who's left? Babish? The guy's one bad jelly donut away from indicting Krispy Kreme). This is probably why CJ "The Giant" Cregg had to dip into the press pool with weirdly high maintenance reporter and Richard Dreyfuss look-a-like Danny Concannon. But back to Charlie, isn't his relationship with President Bartlett a little bit odd? He's in and out of bed with Zoey Bartlett the whole time and was partially responsible for her abduction by terrorists. Yet Bartlett endorses him at Georgetown Law and hands over to him the Bartlett family copy of the U.S. Constitution?
As for Helen Santos being our country's hottest first lady, I have to disagree. Although I'll admit she is good looking and a definite improvement to Abby Bartlett, her general displeasure about everything going on around her puts her behind Jackie O on my list (I'll save you my argument for Angelica Singleton Van Buren). Give me a First Lady with class and style (Hey Helen, nice pearl necklace at your husband's inaug. Please smile every now and then.)
But can we talk more about Progressivism made flesh, Toby Ziegler? The guy can recite the constitution from memory, and protects civil liberties at any chance. So why is he so angry all the time? Does the injustice of a closed society anger him to the point of yelling at everyone that passes by?
Markley: You won't get any argument from me that Helen Santos needs to take Xanax and chill the hell out. "Oh the Secret Service replaced our windows with bulletproof glass!" Lady, your husband is the first Latino candidate for president in American history. What did you think was going to be involved? Jesus Christ.
Okay, you're right, I got annoyed thinking about the First Lady-elect. But Toby Ziegler? The greatest policy mind of his generation? Toby's angry all the time because he was there on the front lines of the Civil Rights movement. He's the quintessential flower power baby boomer, who instead of selling out and voting Reagan, got into government and attached himself to the most promising presidential candidate since FDR. Can you imagine taking Toby's Columbia class? The debates on the use of drones or warrantless wiretapping alone would be worth the hefty Ivy League tuition.
And all this brings me to the most important question of all: If you're running for president, and you can have only one guy in your corner, who you got? Josh Lyman, Bruno Gianelli, Toby Ziegler, Leo McGarry, Mike Novick from "24" or Doug Stamper from "House of Cards"?
Pat: Great question, one that deserves a lot of thought. But first, we can't be completely certain that Toby goes on to be an esteemed professor at Columbia University and not an expatriate living in the Republic of Colombia (a country in desperate need of Toby's skill set for democratic governing).
If I'm running for president, and I can only have one guy in my corner (and Frank Underwood is not available or has not killed me yet), I choose the political bulldog and ex-consigliere, Bruno Gianelli. The only blunder on his resume is the Vinick campaign, but without the nuclear meltdown, Vinick wins Nevada, giving him the election. What Bruno was able to do for Bartlett's reelection campaign is nothing short of remarkable. Bartlett assassinated the Qumari defense minister without declaration from Congress and lied to the American public about a life-threatening illness. What does Bruno do? He comes out and orchestrates a landslide victory. It's very hard for me not to go with Josh Lyman here, though, especially with the sweet back pack he rocks in clear defiance to the bureaucratic norm. Also hard not to go with the versatile utility man and Chief of Staff to House Majority Whip, Doug Stamper. Sure, Stamper can play damage control with the best of them, but does he have a fifty state strategy? Does he know when women have been over sampled in exit polling? In the end, Bruno gives me what I need in order to win the general election: experience, muscle, mafia ties.
Markley: That is the most ridiculous answer in the history of American electoral politics. Bruno Gianelli is a mercenary, a gun for hire. He has no backbone or convictions. He's just a guy who knows how to goad the electorate into doing a particular candidate's bidding, and he doesn't care if that's pushing an anti-gay marriage agenda to shore up the Republican base or downplaying the extrajudicial assassination of a defense minister from a country that appears to have no exact geographic coordinates (no wonder they're so dangerous). Bruno's a glorified Doug Stamper. You want a body buried? Sure, get me Stamps. You want to win an election on principle with a strong governing mandate, line me up baby boomer extraordinaire Toby Ziegler or the guy who took a retiring Matt Santos from a Texas district and engineered the greatest upset in political history. I guarantee you the "Markley for America" campaign would decimate you in the general election given our preferred consultants.
Pat: No one would ever write "Markley for America" on a cocktail napkin, unless it was part of a made up scribbled address from a chick you met at a bar. And there is no way you could ever carry a general election regardless of who is calling the campaign shots. You want to get rid of private schools, eat dogs, and tax top earners at 90%. Even if a human centipede doctor combined Toby, Stamps, Bruno, and Josh into one person to run your campaign, you would still never come close to winning. Although I will concede that you would probably lock up Massachusetts and New York. But an anti-private school, pro-dog eating, tax the wealthy platform and a centipede super person campaign manager will not resonate anywhere else.


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Zsa Zsa Gabor is in debt to the tune of $100K, according to lawyers who filed a massive lien for the actress several years ago.
The legendary film star reportedly lost about $7 million in Bernard Madoff's far-reaching Ponzi scheme, Gabor lawyer Chris Fields told the Associated Press Saturday.
The tax bill, filed in 2001 and 2002, is part of the fallout, according to Fields.
U.S. & World
Gabor, 92, who is married to long-term lover Frederic von Anhalt, is working to square away the debt, Fields said -- and are cooperating with the Internal Revenue Service.
The Hungarian actress and socialite is best known for her rocky love life, which saw the star marry nine times and divorce seven. She starred in some 40 films and a multitude of television shows from 1952 to the mid-1990s.


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Awesome system!!!! How do you like your Stout kettles? I have been considering the same ones.... they seem to be generally well-liked.Thanks for the inspiration!
If I understood correctly then, what you are experiencing is the steam condensing on the underside of the lid, then ultimately at least some of it is rolling between the lid and kettle then dripping or rolling down the outside of the kettle? I can see that as being annoying... not a deal breaker, like you said, but it's hard enough keeping everything clean as it is! Does it happen while the lid is just sitting there, or mainly when you lift and tilt it?I wonder if a silicone gasket along the top of the kettles would help? I can't find the original link, but I saw someone who wrapped their false bottom with a silicone ring. I saved the link to McMaster in case I wound up needing to solve a similar problem. Not 100% sure which one they used in their particular case, but there are a lot of options... Link: http://www.mcmaster.com/#edge-seals/=m4bjpr
If I could sneak in a few more questions... I was also looking at Stout's 1bbl system that comes with 13" legs. I thought that would be kind of low to get the pumps primed good (so I would have to go ahead and build a stand anyway).... Yours though appears to be in the same general neighborhood height-wise. Any issues with that?
I'd like to still have the option to do 10gallon batches. The Stout kettles are only about 5 inches wider than my current ones (15.5g Bayou Classics)... So I THINK that I could still get away with it if I can get everything mounted low enough (would like 2 heating elements in the BK and HLT and Stout appears to stagger them vertically as well as different angles). Think (or know) a small batch is still doable?
I see the RIMS tube in your pics.... Did you go with Stout on that too? They seem to have a nice price on that. Any issues with RIMS hitting your target temp(s) on a 1bbl batch? I use HERMS today on 10 gallons and generally don't do any protein rests or anything "fancy" but would like to leave as many options on the table in the future as possible. HERMS has been great, but I'm questioning it on my next build because I think that it would have quite a bit of lag if I was indeed trying to do any temp steps in the mash. But that's just in my head, not from actual experience..... Thanks again!Jason
I really appreciate the pics.... Thank you for taking the time to do that, it helps me a lot. Those certainly look a lot bigger next to a tape measure! That is the ONE thing (so far anyway!) I don't like about Stout, they are way too light on pictures on their website. Had to piece this together in my head from folks like yourself who were kind enough to share.Yeah, it looks like I'd be pushing it trying to get 10 gallons in. Maybe I shouldn't be selling my current system after all.... going to want a home pilot brewery next. Again, thank you very much for your time and insight... My mind is swimmmming with having a blank slate to start fresh with again and I need to start getting some decisions made!
How much did all of that cost?
Quote from: jimbo2 on April 02, 2013, 10:57:49 PMHow much did all of that cost?That is the one question I won't answer. Suffice it to say you could do it for less.
Quote from: bentwood on April 02, 2013, 11:58:24 PMQuote from: jimbo2 on April 02, 2013, 10:57:49 PMHow much did all of that cost?That is the one question I won't answer. Suffice it to say you could do it for less. my system isn't quite as elaborate as yours, and i cringe when even my nonbrewing friends say "damn, how much did all this cost?!" at least its less than what most car guys spend on rebuilds!


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I'm thrilled that a couple of attendees have blogged my talk, in particular, my June 18, 2009 London presentation. John Welsh posted "Seth Grimes on the semantic web - but is B2B media ready to benefit?" and Peter Thomas's write-up was titled "Literary calculus?" (I don't know why these two Brits are so enamored of question marks.)
As an aside -- Peter had earlier posted a blog article, "A first for me...," noting that he "received my invitation to the event through Seth himself after having made contact with him on twitter.com." I'm the first person Peter has met "IRL" -- you can surely guess what those letters stand for -- post our twitter contact. I similarly met analyst Merv Adrian that way. We became twitter friends through mutual real-life contacts. Then one May morning he tweeted that he was in New York City for a meeting, near Penn Station. It so happens that I was in New York to attend a different meeting, and I was staying near Penn Station. Forty-five minutes later, Merv and I were sitting down to breakfast. (For you foodies: We met at the Tick-Tock Diner at the corner of 34th St. and 8th Ave and both had the excellent corned-beef hash.)
Back to Text Mining, Web 3.0 & the Semantic Web -- If you'd like to listen to a recording of my Nstein webinar, please visit http://www.nstein.com/en/ondemand_webinars.php . Let me know what you think!
Posted June 26, 2009 3:13 PM
Permalink | 1 Comment |


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Herr Algis Rukas
Artojo g. 6
92105 Klaipėda
DVR Paslaugos" - a mature company which already has fourteen years of experience in marine engines and other marine equipment repair services. Certified by Lithuania Maritime administration and Russian Maritime register.
The company was opened in 2005, 24th of August. It operates not only in Lithuania but in other countries as well. Spain, Poland, Latvia, Russia, Norway, Finland, the Netherlands are the main foreign customers. Cooperation with foreign customers opens wider possibilities to integrate into other markets, to develop rapidly and to gain international experience, which after can be used in own country. Mature work experience, reliable and competent staff helps to ensure the highest quality of services.


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The Latham Reservoir dam burst in 1973, flooding Kersey on the Colorado plains
In the farm community of Kersey, in Weld County, citizens were evacuated abruptly on April 12, 1973 after the Latham Reservoir dam, 4.5 miles to the southwest, gave way at 9 a.m., spilling 5,700 acre-feet of water into farmland and the streets and homes of Kersey.
In the photo above, looking west, the high school is visible in lower right. The northern two-thirds of the community received the brunt of the flood with areas in the south escaping damage. The greatest damage was estimated, early on, to be to the Platte Valley Schools, portions of which had recently been updated. Residents were grateful they had warning in time to leave the town safely.
In the photo below, cattle are herded to slightly higher ground. There is an interesting hand-written caption on the back of this photo that is also posted here, for its colorful description of events. It was written by Denver Post photographer Barry Staver.
If you look closely, you can see the trail the cattle made through the mud.


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Business school sometimes get a bad rap in the startup world. Some of it is deserved – it's big opportunity cost, and until fairly recently, the approach to most business schools to entrepreneurship has been more about theory than practice.
Thankfully this is changing. But what is very positive about business school and what hasn't changed is that they are an amazing collection of people and opportunities that can significantly shape ones education and even personal character. Many of the founders we've backed at NextView are graduates of top business schools and bring many of their leanings from those two years to bear.
As I think back on my own business school experience, I often recall three very important lessons and pieces of wisdom that impact me every day. One was academic, one was advice from a professor, and one was self discovered thanks to the entirety of the 2-year experience,
Lesson #1: What Makes a Good Market
Before Business School, I had heard of Porter's 5 Forces and probably memorized it at one point during preparations for consulting interviews. But I really started to internalize the concept at business school and I think of it every day. When one thinks of attractive markets, it's easy to just think of markets that are "really big" and "growing fast". However, that is NOT what makes a market attractive.
A market is attractive relative to the player involved. And its attractiveness to that player is based on how the forces in the market work to make it easier or harder for that player to create and extract value. The forces described by Michael Porter in his framework are:
– bargaining power of suppliers
– bargaining power of Customers
– competitive rivalry
– threat of new entrants
– threat of substitutes
I don't want to spend much longer on this point, but I've found this immensely helpful. And it's not just important for investors who are analyzing new businesses in different markets. But it also dictates the strategy of a founder as they think about their own market and what they need to do to win.
For some additional thoughts of mine on the difference between BIG markets and ATTRACTIVE markets, see this post here:
Lesson #2: Authenticity Works
Authenticity works. It was an off-hand comment from Felda Hardymon during office hours one day when I was a student in his VC/PE class. But it was a word of wisdom that I really try to take to heart for myself and when speaking to entrepreneurs.
It turns out I'm a pretty socially awkward person. But much of business school (and much of business interaction) are awkward social situations. Think about difficult conversations with employees, cocktail parties, cold calling, negotiations, selling, etc. Those types of situations are a nightmare for someone like me.
But I've continuously found that when in doubt, the best thing to do is to drop any social posturing and be authentic. Talk about what really gets you excited and what you really care about. I remember when was interviewing for my job at Spark, one partner questioned my willingness to take risks and pound the table for what I believed. I ended up telling him the story of how I pursued my wife – a very personal but authentic story, and it won him over.
Similar things happen when we speak to entrepreneurs at NextView. We love founding stories that are driven by highly authentic experiences in a market or with a problem. We also love interacting with entrepreneurs that are transparent about the things that excite them about their businesses and the things that they worry about or are really hoping go their way. It's a highly personal business after all, and we try to put that front and center as a core part of our firm ethos.
Lesson #3: Do the ACTIVITIES You Love
One very interesting aspect of business school is that it can be a 2-year soul searching process about who you are and what you want to do with your life. A lot of business school students find themselves paralyzed, because it feels like there is a lot at stake in the career choice post B-school, especially with large sums of debt and 2-years of opportunity cost.
That said, I think business school is a wonderful time to step back and reflect on what you want out of life professionally and personally. The problem is, I find that when we think about careers or jobs we want, it's easy to get caught up in a lot of different motivations – what would other people think? How can I make the living I'd like? Is this job impactful? What kind of a role is suitable for me? Etc.
But I find that business school students (and especially myself) often don't ask what I think is the most important question. To me, that is – "what activities do you love?". We spend a lot of time at work, and you'd better be doing activities you enjoy, otherwise, it's a terrible way to spend your time until you die. And activities are not jobs. They are not roles or functions. They are activities.
For instance, being a VC and being a doctor are very different jobs and roles. But some of the activities are the same. Doctors and VC's meet people 1:1 or 1 on a few all day long. They have a lot of first time meetings and hear people's stories. They try to solve problems based on pattern recognition. On these dimensions, doctors and VC's do very similar activities.
But you never hear VC jobs and medical jobs compared. You do hear VC's and entrepreneurs compared, and many job seekers out of B-school contemplate both paths. But entrepreneurs do different activities. They sell more (or in different ways), they meet very often with their team to solve common problems. They may actively make design and product decisions, talk to prospective customers for feedback etc. The activities can actually be quite different.
I'm not making the point that being a doctor is more like VC than being an entrepreneur. But my point is to look at jobs and life as a set of activities that you are doing all day long. Do those activities map to what you are excited about doing? Are they activities that are life-giving to you, or draining?
Or, put another way (as I've heard from an old boss and mentor), think of the times when you were happiest at work. What exactly were you doing at that time? Try to do more of it.
That's it. Pretty simple. Don't overthink it or plan too far in the future. Do something that you think is interesting and allows you to spend as much time as possible doing activities you love. I think it's hard to go wrong if that is actually achieved.
So, those are my three biggest lessons learned from 2 years at HBS. Worth the 2 years and $100K+ of fees? You be the judge
This article has been republished with permission from Rob Go's blog . Rob, lives in Arlington, MA, is married and has two young daughters. He and his wife met in college at Duke University. Rob is also the cofounder of NextView Ventures, a seed stage investment firm focused on internet enabled innovation. He spends as much time as possible working with young entrepreneurs and investing in businesses that are trying to solve important problems for everyday people. More professional info here. The best way to reach him is by email: rob at nextviewventures dot com


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FBI releases images of two suspects near Boston bomb sites
- FBI hopes public can identify potential suspects
- Both suspects are considered %27armed and dangerous%27
Federal investigators issued an urgent appeal Thursday for the public's assistance in identifying two suspects in the Boston Marathon attacks Monday. The two were seen on local surveillance camera carrying backpacks near the sites just minutes before two bomb devices were detonated.
Boston FBI chief Richard DesLauriers said the young men — identified as "Suspect 1'' and "Suspect 2'' were the only people authorities were seeking in connection with the blasts, which left three dead and 176 others wounded near the finish line of Monday's race.
Suspect 1 was wearing a black cap, khaki pants, sunglasses and slip-on dress shoes.
Suspect 2 was wearing a white cap backward, jeans and gray hoodie sweatshirt with a black jacket over it. He is also seen casually walking down a busy sidewalk with a pack that investigators believe was set down near the site of the second explosion.
Both suspects' bags appear to be similar to the black nylon pack described earlier as possibly used to carry the explosive devices believed to have been assembled in common kitchen pressure cookers.
DesLauriers said the suspects' photos were culled from streams of video and photographic evidence collected since Monday. Police first became suspicious of Suspect 2 because of his actions and proximity to the second bomb scene. Investigators later found images of Suspect 1, who appears to be traveling with the other person.
"We consider them to be armed and extremely dangerous,'' DesLauriers said at a televised evening briefing. "No one should approach them. No one should attempt to apprehend them except law enforcement. Do not take any action on your own.''
In the unusually blunt appeal, DesLauriers asked the public to closely examine the photographs and report any information to its telephone tip line: 1-800-225-5324.
"No bit of information is too small for us to see,'' he said.
Within minutes of the photos' release, the FBI's website was swamped, temporarily blocking access to the material.
"Identifying and locating those responsible is now our highest priority,'' DesLauriers said.
The release of the images comes three days after the blasts killed 8-year-old Martin Richard of Dorchester, 29-year-old Krystle Campbell of Medford, and Lu Lingzi, a 23-year-old Boston University graduate student from China.
More than 1,000 officers and agents studied 3,000 photographs and many terabytes of digital data to identify the suspects, FBI Special Agent Jason Pack said.
Investigators used several different photos over time to piece together the suspects' paths and association, FBI Special Agent Dan Curtin said.
At a service for victims in Boston on Thursday morning, President Obama vowed the attackers would be caught and prosecuted. "Yes, we will find you — and, yes, you will face justice," he said.
In Washington, Attorney General Eric Holder said Thursday that the "full resources'' of the Justice Department were being deployed in the investigation and to guard against any future attacks.
MORE:Interfaith service held in Boston
FULL COVERAGE:Boston Marathon bombings
Holder, the nation's top law enforcement officer, told a congressional committee Thursday that the "individual or group that carried out this heinous act'' would be held accountable … "by any means available to us"
Holder's comments came after Homeland Security Secretary Janet Napolitano told a House panel that the responsibility for the attack has yet to be linked to any individuals or international or domestic terrorist organizations.
"We don't know,'' Napolitano told a congressional panel, as investigators in Boston continue to pursue a number of promising leads.
Authorities continue working to identify individuals at both sites as well as a number of other people in video and photographs near the explosions.
More than 50 people remain hospitalized, with seven listed in critical condition, down from 14 Wednesday. They include a 10-year-old boy at Boston Children's Hospital whose leg was amputated and a 9-year-old girl with a leg injury. Brigham and Women's Hospital had four people in critical condition and Boston Medical Center had one. At Tufts Medical Center, five bombing victims remain under care, but none are listed as critical.
Meanwhile, families of a newlywed couple who both suffered a leg amputation below the knee are thanking supporters for an outpouring of donations.
The families of Patrick and Jessica Downes said Thursday that the generosity from friends and strangers has restored their faith in humanity. More than 4,400 people have donated more than $246,000 to the couple. Donations can be made through GiveForward.com/helpforpatandjess.
The families say they don't want the couple to worry about paying for prosthetics and modifications to their home during the recovery process.
Thirty-year-old Patrick and 32-year-old Jessica are in stable condition and recovering from surgery. They were married in Boston in August. Jessica is a nurse at Massachusetts General Hospital, one of several area hospitals treating bomb victims.
Contributing: G. Jeffrey MacDonald; the Associated Press


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My moddb blog http://www.moddb.com/members/grimmy307/blogs
Will we be able to use your Cloud with the dirty buster sword?
Please remind me! Huge materia go to which lgp?
Here is a little thing. I added Elmyra and Marlene to Kalm after the Rocket launch. They are total new additions and do not just replace another npc. I put them in the empty upstairs of the second house. If you Don't like the text use Makou Reactor to add you own.http://www.youtube.com/watch?v=_8rqDtmYJgc&feature=youtu.belink on first post.
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