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NBCR - National Biomedical Computation Resource was founded in 1994 to facilitate interaction among biomedical scientists and promote the development of computing power at the national supercomputer centers. Since that time, NBCR has led the development of new technology in computing to benefit the biomedical research community and bridge the gap between emerging information technologies and NIH-funded science across diverse biomedical research areas.
NBCR's vision centers on the development of tools and technologies that enable models to bridge across diverse scales of biological organization that ranges from molecules to organs systems to gain a quantitative understanding of biological function and phenotypes, while enabling biomedical science to take full advantage of all types and sources of relevant data. Our products raise from our Driving Biomedical Projects, and is applied to a board scientific community.
Click here for the list of NBCR Software, WebServices, Workflows, and Software Rolls
Research Highlights
Novel Molecular Dynamics Captures Atomic-level Detail of CRISPR-Cas9 Activity
Using a novel molecular dynamics method capable of capturing the motion of gyrating proteins at time intervals up to one thousand times greater than previous efforts, a team led by UC San Diego researchers has identified, for the first time, the myriad structural changes that activate and drive CRISPR-Cas9, the innovative gene-splicing technology that's transforming the field of genetic engineering. Link to the full article from the San Diego Supercomputer CenterRead More > >
Reproducible MD Simulation on Amber GPU
With the click of a button, a simulation is triggered and a user can visualize the dance a protein performs in a solution. Described above is the combined power of Kepler and Molecular Dynamic (MD) simulations. MD simulation is a powerful tool to study the atomistic details of a biological system. Atom movements across time are predicted by solving Newton's equation. The result is a movie depicting a protein dance performed by underlying atoms. However, MD simulation has several downfalls, especially when it comes to reproducibility.Read More > >
Scientists determine way to increase number of spikes on HIV virion as first step toward development of an effective vaccine
HIV-1 is rare among viruses because of the low number of spikes (potential docking stations) on the envelope that covers the HIV virion. This number is typically in the range of 7-14. It contrasts with the much higher number of spikes on other viruses like influenza that features 400-500. Some viruses feature as many as 1,200.Read More > >
Visualizing Biological Specimens at Nanometer Scale Using a New Automated, More Detailed Method
The ability to locate and visualize proteins and macromolecular complexes in cells and tissues in 3D high resolution continues to be a challenge in biomedical studies. Various techniques and tools are key to this work. For example, light microscopy uses fluorescent labels to track elements of interest, but it provides an incomplete view, including only the distribution of the labeled elements. Researchers who want to collect more comprehensive 3D datasets at higher-resolution use electron microscopic tomography (EMT) to visualize all structures in the cellular or subcellular domain under investigation.Read More > >
Allostery and Protein Dynamics Across Scales
There's long been a standard tradeoff in biochemistry: You can study overall shape (of, say, a macromolecule or an organelle) or high-resolution detail within, say, at the 10-40-nanometer scale. Seeing both at the same time would be one of today's scientific Holy Grails.Read More > >
Biomedical Big Data Training Collaborative
For the last 5-10 years, a lot has been said and written about "big data" and the insight it's reputed to hold – if only you can find an efficient, effective way to get at it. But big data can be a bewildering topic, as there seem to be as many types and formats of big data as there are methods to analyze it.Read More > >
Multi-scale Simulations with Applications for Drug Design
Lane Votapka, relaxed from a recent successful defense of his PhD research, sets the stage for the work he published this fall with his advisor and NBCR Director Rommie Amaro at UC San Diego: "The cell is made up of proteins and other large molecules.Read More > >
cellPACK – a new tool to build complex systems
In collaboration with QB3 Fellow Graham Johnson at UCSF, NBCR investigators Art Olson and Michel Sanner have developed cellPACK, a new software tool to build increasingly complex systems.Read More > >
cAMP Binding Causes Protein Kinase Activation
In spite of several decades of research, scientists have been unable to describe in rigorous quantitative terms the exact sequence of events that leads to activation of Protein Kinase A (PKA) by cyclic adenosine monophosphate (cAMP). But a research team at UCSD will soon publish results that explain this mechanism for a PKA isoform essential for proper functioning of the heart.Read More > >
Experimentation and Computation Meet
A normal heart uses the complementary, alternating activities of "systolic" contraction and "diastolic" relaxation to pump blood throughout the body. So scientists are eager to understand the various factors that affect this process, including those that lead to heart disease and failure.Read More > >
Finding New Anti-Flu Compounds
By comparison with his peers, Eric Chen might be considered a veteran researcher. Currently a senior at Canyon Crest High School in northern San Diego County, he has already worked for two years in several laboratories – both computational and bench science – at UCSD and The Scripps Research Institute.Read More > >
Ilkay Altintas: Advancing Computational Research with Scientific Workflows
It was a lark that brought Ilkay Altintas to San Diego. The year was 2001. She had just finished her M.S. thesis and was working at the Middle East Technical University in Ankara, Turkey, when she discovered an open position at the San Diego Supercomputer Center (SDSC).Read More > >
New Molecular Dynamics Method
A team of NBCR researchers recently demonstrated a new accelerated molecular dynamics (aMD) implementation that enhances sampling of the conformational space of biomolecules by several orders of magnitude. More specifically, they developed an implementation of the aMD method using the OpenMM toolkit library to produce high performance – and, as a result, longer simulation times – on graphics processing units (GPUs).Read More > >
Nucleotide Diffusion in the Cardiac Myofilament Lattice
An NBCR research team recently published a paper investigating the spatiotemporal diffusion of adenine di- and triphosphate (ADP and ATP) nucleotides through the myofilament lattice in heart muscle. The investigation of diffusion of these biomolecules is important because they regulate cardiac energetics and coupling between cell excitation and contraction.Read More > >
Accelerated Molecular Dynamics Simulations
Using just an upgraded desktop computer equipped with a relatively inexpensive graphics processing card, a team of computer scientists and biochemists at the University of California, San Diego, has developed advanced GPU accelerated software and demonstrated for the first time that this approach can sample biological events that occur on the millisecond timescale.Read More > >
Calcium Sparks Generation
Triggered release of Ca2+ from an individual sarcoplasmic reticulum (SR) Ca(2+) release unit (CRU) is the fundamental event of cardiac excitation-contraction coupling, and spontaneous release events (sparks) are the major contributor to diastolic Ca(2+) leak in cardiomyocytes. Previous model studies have predicted that the duration and magnitude of the spark is determined by the local CRU geometry, as well as the localization and density of Ca(2+) handling proteins.Read More > >
Intracellular Calcium Dynamics Model
According to the Centers for Disease Control and Prevention (CDC), heart diseases are the number one cause of death in the US. Heart attacks are caused by blockages in coronary arteries, and heart failures or in severe cases, cardiac arrest, are often caused by irregular heart beats or arrhythmias.Read More > >
Myosin light chain kinase dephosphorylation
Actin-myosin interactions provide the driving force underlying each heartbeat. The current view is that actin-bound regulatory proteins play a dominant role in the activation of calcium-dependent cardiac muscle contraction.Read More > >
New drug effective against MRSA
Millions of people die each year from bacterial infections in tuberculosis or pneumonia. The bacterium, Staphlococcus aureus, while usually harmless, may lead to ear infection, sinusitis, pneumonia, meningitis, toxic shock syndrome and a number of postsurgical infections.Read More > >
Pocket Full of Promise
Cancer remains the second leading cause of death, after heart diseases, in the US, and millions of people die from different types of cancer worldwide each year. The known tumor suppressor protein p53 is an important regulator of cell growth in normal cells and its dysfunction is closely related to tumor development and progression.Read More > >
Versatile Python API
The uPy Python extension module provides a uniform abstraction of the APIs of several 3D computer graphics programs (called hosts), including Blender, Maya, Cinema 4D, and DejaVu. A plug-in written with uPy can run in all uPy-supported hosts.Read More > >
Active Conformational States
Lauded by Biomedical Research Community , the relaxed complex scheme (RCS) is a promising computational method for computer-aided drug discovery (CADD) that combines the advantages of docking algorithms with the dynamic structural information provided by molecular dynamics (MD) simulations.Read More > >
Attacking Chagas Disease
Projects in Scientific Computing publishes an article describing Studies with Anton, a special-purpose supercomputer designed by D. E. Shaw Research and made available at PSC, that have yielded new insights into the motion and function of proteins.Read More > >
Better Understanding of Heart Failure
Modeling Calcium Dynamics in Ventricular Myocytes with Realistic Transverse Tubules/em> What is known as cardiac remodeling (or ventricular remodeling) is not a good thing; it implies that there is a decline in the function of the heart.Read More > >
Biomolecular Electrostatics
Scientists use a number of tools to investigate how cells develop, operate, communicate, and control their activities. Molecular interactions have several components, including biomolecular electrostatics, which is considered to be of special importance because of its long range nature and influence on polar or charged molecules (primary components in living systems).Read More > >
Major Step in Heart Modeling
A "picture" of your failing heart is worth a thousand words. The development and clinical use of patient-specific models of the heart is now a possible goal. Models have the potential to help with diagnosis and support decision-making for cardiologists and their patients. Several research groups are now working to develop multiscale models of the heart; these models integrate the many physiological functions taking place in the heart.Read More > >
Tool Speed up for Computer-aided Drug Discovery
Found to be an efficient approach Drug discovery and design involves finding small molecules that are complementary in shape and charge to the biomolecular target with which they interact so that they will bind to it. Applying computational power to the combined chemical and biological aspects of this process is an ever-growing effort because doing so improves the speed of the process and development of effective treatments.Read More > >
Visualization and Modeling Integration
Bringing modeling and animation into one interface and improving interdisciplinary collaborations: Increasingly complex research has made it more difficult to prepare data for analysis, publication, education, and outreach. Many scientists must also wade through what seems like black-boxes with mysterious code that works "magic" to generate results with computational algorithms from diverse sources in order to supplement their laboratory (bench) work.Read More > >
Latest News
C&EN talks with Rommie Amaro, computational chemist: Amaro discusses how she uses molecular dynamics simulations to find new cancer drug leads
Determining the structures of enzymes and other biomolecules with X-ray crystallography has deepened biologists' understanding of the inner workings of cells and led to the design of many important drugs. Increasingly, researchers are using computer modeling to attain a more realistic picture of the movement of these biomolecules in their natural environment. Rommie E. Amaro, a professor of chemistry and biochemistry at the University of California, San Diego (UCSD), uses computational techniques to predict how enzymes regularly shift their configurations, revealing potential vulnerable areas for drug targeting. C&EN talked with Amaro about how she's using dynamic models of enzymes to develop a new class of cancer drugs, work that is being commercialized by Actavalon, a San Diego start-up Amaro cofounded. Link to the full article from the American Chemical SocietyRead More > >
Using data science to return people to the labor force: New center at Computation Institute to unify labor, training, education and employment data
Despite persistent unemployment in the United States, millions of jobs are hard to fill due to a lack of qualified applicants. While community college and training organizations seek to equip people with the skills required for these openings, it's a moving target as the American economy rapidly changes. Link to the full article from The University of ChicagoRead More > >
TSRI Scientists Awarded $6.6 Million for Research in Computational Biology
Three groups at The Scripps Research Institute (TSRI) have been awarded grants from the National Institutes of Health (NIH) to develop methods for computational modeling and to apply them to cutting-edge systems in biology and health. "The three projects are highly symbiotic, each addressing a different state-of-the-art challenge in computational biology, but built using a common computational framework that will allow facile collaboration between the groups," said Professor Arthur Olson, founder of the Molecular Graphics Laboratory, which is currently part of the TSRI Department of Integrative Structural and Computational Biology. Link to the full article from the Scripps Research InstituteRead More > >
Supercomputing the P53 protein as a promising anticancer therapy
Even though it's almost impossible to see, computational biophysicist Rommie Amaro is using the Stampede supercomputer at the Texas Advanced Computing Center at The University of Texas at Austin to model the largest atomic level system of the tumor suppression protein p53 to date — over 1.5 million atoms. The simulations identify new "pockets" to reactivate p53 which would be a tremendous boost for future anti-cancer drug iscovery. Link to full article from Texas Advanced Computing CenterRead More > >
This protein is mutated in half of all cancers. New drugs aim to fix it before it's too late
It has been nearly impossible to get a good look at Rommie Amaro's favorite protein in action. Called p53, the protein sounds the alarm to kill cells with DNA damage and prevent them from becoming cancerous—one reason why it has been called the "guardian of the genome." But it is big and floppy, a molecular shapeshifter that is hard to follow with standard imaging tools. So Amaro, a computational biologist at the University of California (UC), San Diego, turned to supercomputers. Link to the full article from the American Association for the Advancement of ScienceRead More > >
Science at cusp of 'transformational' grasp of life via cell modeling, researchers say
A paper recently published in the Journal of Molecular Biology shows how advances in molecular biology and computer science around the world soon may lead to a three-dimensional computer model of a cell, the fundamental unit of life. According to the authors, the development could herald a new era for biological research, medical science, and human and animal health. Link to the full article from Phys.org
Read More > >
La Jollan wins top prize in Theoretical Chemistry
J. Andrew McCammon, a distinguished professor of chemistry, biochemistry and pharmacology at UC San Diego, has won the 2016-17 Joseph O. Hirschfelder Prize in Theoretical Chemistry, awarded by the Theoretical Chemistry Institute at the University of Wisconsin-Madison. A physical chemist who is also a fellow of the San Diego Supercomputer Center and a Howard Hughes Medical Institute Investigator, McCammon is the second UCSD chemistry professor to receive the prestigious prize, following Peter Wolynes in 2009. Link to the full article from the La Jolla LightRead More > >
Promising drug leads
Using a unique computational approach to rapidly sample, in millisecond time intervals, proteins in their natural state of gyrating, bobbing, and weaving, a research team from UC San Diego and Monash University in Australia has identified promising drug leads that may selectively combat heart disease, from arrhythmias to cardiac failure. Please see links to a Full article in UC San Diego News Center and a published paper.Read More > >
Andrew McCammon is 2016-17 Hirschfelder Prize Recipient
Professor J. Andrew McCammon will receive the 2016-17 Joseph O. Hirschfelder Prize in Theoretical Chemistry, administered by the University of Wisconsin-Madison Theoretical Chemistry Institute (TCI). McCammon is a professor of chemistry, biochemistry, and pharmacology at the University of California, San Diego, where he holds the Joseph E. Mayer Chair of Theoretical Chemistry. He also is a member of the National Academy of Sciences and a fellow of the American Association for the Advancement of Science and the American Academy of Arts and Sciences. Link to the full article from the University of Wisconsin-Madison Department of Chemistry.Read More > >
Report from the Summer School in Computational Physiology
17 students attended this year's Summer School, a joint venture in Computational Physiology between the University of Oslo, University of California, San Diego, and Simula. The Summer School is now in its third year, and including this year's group we have a total of 44 graduates from the school. This summer, 15 of the students were PhDs and two were Master's students, selected from a pool of international applicants. Link to the full article from simulaRead More > >
Computing transforms chemistry, biotech
The life sciences are going dry. While test tubes, Petri dishes and cell cultures abound in the biotech world, the frontiers of exploration are increasingly taking place on high-powered computers and supercomputers. Equipped with ever better microprocessors to perform calculations and render graphics, computers today run extraordinarily powerful software that sheds light on biomedicine at every scale — from the physics of atomic-level interactions to sophisticated models of how tissues function. Link to the full article from the San Diego Union TribuneRead More > >
Computer Simulations Aid Search for "Resistance-Resistant" Antibiotics
With the growing threat of drug-resistant bacterial infections, new antibiotics are sorely needed. But we need truly novel classes of antibiotics, not just new versions that kill bacteria the same singular way existing drugs do, says J. Andrew McCammon, PhD, Distinguished Professor of Pharmacology, Chemistry and Biochemistry, and Joseph E. Mayer Chair of Theoretical Chemistry at UC San Diego. We need "resistance-resistant" antibiotics — drugs bacteria won't easily be able to ignore. Link to the full article at News from UC San Diego Health Sciences.Read More > >
The recipe for Big Data
What do a cookbook and big data have to do with each other? Quite a bit, said Ilkay Altintas, the chief data science officer for the San Diego Supercomputer Center, motioning to the book "How to Cook Everything Fast," which sits prominently on her office desk. Although it might seem like an odd choice of literature for Altintas, she sees it as central to her work. "That's my dream project," Altintas said. Link to the full article from UC San Diego Extension.Read More > >
Rommie Amaro: The Kavli Foundation Emerging Leader in Chemistry Lecture
Rommie Amaro giving the ACS Kavli Emerging Leader in Chemistry National Lecture at the Spring ACS.
Please see AMBER GPU MD workflow download linksRead More > >
Rommie Amaro highlighted in Biophysics Week
The Biophysical Society's Committees for Inclusion and Diversity (CID) and Professional Opportunities for Women (CPOW) have highlighted Rommie Amaro as an outstanding biophysicist who represent the diversity within the field.Read More > >
Andrew McCulloch's article for Biophysics Week
Andrew McCulloch's article about multiscale modeling for Biophysics Week!Read More > >
Ilkay Altintas wins the TCSC Award for Excellence
Ilkay Altintas wins the TCSC Award for Excellence in Scalable Computing for Early Career ResearchersRead More > >


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Find something your kids like to do, and incorporate Spanish into that activity.
My kids, (especially the youngest one), like video games, and so we have a video game that teaches Spanish. The Nintendo DS game my kids have is called, "My Spanish Coach." The kids like to play it and it adjusts to skill level so it is good for any age or ability.
Bonus tip: My older son has also switched the language mode on his Nintendo DS to Spanish, so regardless of the game he's playing, even if it's just Mario and Luigi bouncing around, he still practices his Spanish.
On a side note:
I was looking for the "My Spanish Coach" game on the internet yesterday so I could get an image to show you, and instead of "My Spanish Coach" coming up first in search results, I was getting "My English Coach: Para Hispanoparlantes".
Qué interesante, verdad?
I'm wondering if this means anything from a sociological standpoint. Anyway, we may have to buy this new game for my husband.

subset: commoncrawl


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It should have occurred to me but it didn't. If the Virgen de la Luz is escorted into town every September for the week of Feria she must have some way of getting back out to her shrine afterwards so she can do the whole thing again the following year. I hadn't given the matter much thought but if pushed I suppose I imagined her being secreted away under cover of night when all the excitement had died down, or perhaps popped onto the back of a pickup as surreptitiously as possible. Nothing to see here folks, type of thing.
But that would mean the Spanish passing up on the opportunity to have a procession, which of course is inconceivable. And so it was that I found myself outside the church in the centre of town this last Sunday, unable to move for all the people, most of them of a certain age and all in their Domingo best. More


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Anne Schwanewilms: Das himmlische Leben
Franz LISZT (1811 1886)
1. Der Fischerknabe [3:39]
2. Der Hirt [3:31]
3. Der Alpenjäger [2:01]
Gustav MAHLER (1860 1911)
4. Urlicht [4:50]
5. Rheinlegendchen [3:24]
6. Um schlimme Kinder artig zu machen [2:20]
7. Verlorne Müh! [3:04]
8. Ich ging mit Lust durch einen grünen Wald [5:01]
9. Ablösung im Sommer [2:07]
10. Wo die schönen Trompeten blasen [7:24]
11. Nicht wiedersehen! [5:22]
Franz LISZT
12. Oh! quand je dors [4:22]
13. Die Loreley [6:43]
Gustav MAHLER
14. Das himmlische Leben [10:13]
Anne Schwanewilms (soprano), Charles Spencer (piano)
rec at TONAL audiophile productions, Vienna, 21-25 February 2012.
Sung texts with translations in English and French enclosed.
Mahler openly declared that he was inspired and influenced by Liszt, more directly for his symphonic writing. The Faust symphony was a seminal work in that respect. Beypnd that there is also a point in matching the two composers on a song disc. Most of those here are often heard but there are a few exceptions.
The opening three songs by Franz Liszt are from Schillers Wilhelm Tell. They are fairly short and all are from the beginning of the play. Der Fischerknabe opens with a long prelude where one can hear the sounds of water. The young fisherman falls asleep on the shore and when he wakes the water has risen up to his breast and the water sprite drags him down. The shepherd in the second song says farewell to the meadows when he leaves because summer is over. In the dramatic Der Alpenjäger the heights thunder, the footbridge trembles but the hunter fears nothing. Anne Schwanewilms is in her element here with her spinto voice ringing out fearlessly. These three songs should be heard more often.
Urlicht, composed in 1892 and orchestrated the following year was originally part of the twelve Songs from Des Knaben Wunderhorn but was later removed and incorporated in Symphony no 2. It is one of Mahlers most beautiful songs but it is rarely heard with piano accompaniment. It is nobly sung here with lovely tone. Rheinlegendchen is sung with folksong like simplicity, very enticing indeed, and so is Um schlimme Kinder artig zu machen, performed with more than a glint in the eye. Ich ging mit Lust is a song I frequently return to, it has for me, in all its modesty, a certain tingle-factor. For some years now I have treasured Katarina Karneus reading on her debut recital disc. Schwanewilms version is just as satisfying and so are the rest of this Wunderhorn group.
Two sharply contrasting songs by Liszt, two of his very best, settings of two of the foremost poets of the century, follow. Victor Hugos Oh, quand je dors is a song I first heard with the British tenor Heddle Nash, accompanied by Gerald Moore. This 1948 recording still has an honoured place in my collection. Schwanewilms dreamy reading conveys much of the same atmosphere. Then she turns on the over-drive for Heines Die Loreley in a marvellously dramatic version of this evergreen. After this she changes gear again with soft singing of the utmost delicacy in the final pages. There is only one word for it: ravishing!
Das himmliche Leben was composed in 1892 and intended also for the second symphony, but Mahler changed his mind and in the end it became the final movement of the fourth symphony. Though this too is a Wunderhorn text it was never included in the group of twelve, nor was there a version for voice and piano. I suppose what we hear on this disc is a piano reduction of the orchestral score. Be that as it may, as sung and played here it is a worthy supplement to the other songs.
According to her official home page Anne Schwanewilms is a lyric soprano but judging from this disc and the fact that among her operatic roles is Die Kaiserin in Die Frau ohne Schatten, she could just as well be labelled dramatic. Her voice encompasses all the requirements for intimate lyrical songs as well the big dramatic outbursts and her tone is certainly among the most beautiful to be heard today. She has a pliable accompanist in the experienced Charles Spencer and the recording is excellent.
A fresh and stimulating disc.
Göran Forsling
A fresh and stimulating disc.
Support us financially by purchasing this disc from


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CURRICULUM IN CONTEXT is a guidebook for teachers and curriculum designers who are preparing to write curricula for use in pre-K through 12 classrooms and post-secondary settings. This text focuses on contextual teaching and learning (CTL), a system of instruction that enables students to find meaning by connecting the content of the lesson with the context of their lives. The book's practical focus provides teachers and administrators with the concepts and skills they need to make curricular and instructional decisions appropriate for their schools and classrooms. Author Leigh Chiarelott presents some of the most popular models for curriculum development, beginning with the classic Tyler "4 questions," and leading into more contemporary models, such as Wiggins and McTighe's "Backward Design." Unlike other available texts, CURRICULUM IN CONTEXT treats the principles of contextual teaching and learning as an integral element of the curriculum design process.Chiarelott, Leigh is the author of 'Curriculum In Context Designing Curriculum and Instruction for Teaching and Learning in Context', published 2005 under ISBN 9780534592127 and ISBN 0534592120.[read more]
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Woman's remains kept in Rubbermaid container
Victim's Name: Carolyn Baker Jansen
Where killed: 1549 N. Nome St. apartment
Investigative agency: Aurora Police Department
When killed: Early 2002
Cause of Death: Trauma to head
Suspect: Jon Harrington
The skeleton of a woman last seen staying in an apartment with Jon Harrington was stuffed in a Rubbermaid container sealed with duct tape.
The container was found among belongings he left on the back porch of an Aurora home in 2005. He told police the box in which Carolyn Jansen's bones were found was his, though he said he hadn't seen her since 2002 and didn't know what happened to her.
But while Harrington was briefly arrested for investigation of murder, he has never been charged with the crime — and denies any role in her death. Jansen's murder officially remains unsolved — if it was a murder at all.
The case has exposed a deep disagreement among Arapahoe prosecutors, Aurora police and the county's coroner. The coroner said he believes Jansen's death was murder and police officers think there is enough evidence to make a case against Harrington.


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Stenson outduels Stricker
Stenson wins Deutsche Bank Championship
NORTON, Mass. — A great summer of golf finally paid off for Henrik Stenson when he won the Deutsche Bank Championship.
Stenson raced by a fast-fading Sergio Garcia on Monday, and he holed a bunker shot on the 17th hole to turn back a final threat from Steve Stricker. The Swede, who had close calls in two majors, closed with a 5-under 66 and tied the tournament record at the TPC Boston. He won by two shots over Stricker.
Labor Day at the TPC Boston was loaded with drama.
Brendan Steele birdied his last four holes to advance to the third playoff event in Chicago. Ernie Els made it by a fraction of a point. And Zach Johnson made a 25-foot birdie putt on his last hole to make the Presidents Cup team.


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Viewing this webinar requires some basic information. This data is only used within SCORE and will not be distributed to any third parties.
Whether you're a fully-established business or just opening your doors, the relationships that you make and the manner in which you communicate with your customers and prospects will have a significant impact on your success.
In the world of email marketing, your list has tremendous potential value -- value that "doing the same old thing" or "taking no action at all" won't tap. In this mobile-first era, it's imperative to rethink how that message is being delivered and consumed.
Attending this webinar presented by Matthew Montoya with Constant Contact, will help you answer the questions you should be thinking about:
- Could you or your employees be doing a better job when asking for information?
- Is your business utilizing all of the available tools at your disposal to collect information securely?
- Are you following through on your promise to provide relevant information (that's delivered in a way they'll want to consume it) to those that want to hear from you?
If you haven't thought about your email marketing strategy in a while (or ever), now is the time!
Download the webinar transcript.


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When you see a wrecked late-model car for sale, you might have questions about what caused the wreck. Not so with this '06 Legacy!
Yes, the gauges are showing a snapshot of- presumably- what was taking place at the moment the main computer got knocked out by the impact. Over six grand on the tach, 120 per on the speedo… whoa, where did the traction go? Thanks to LTDScott for the tip! [Craigslist Sacramento, go here if the ad disappears]


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It is a new year for Apple ? and with it, a season of the new iDevices is almost here. After several changes in the company core the one holding responsibility for the iOS platform is not Scott Forstall, its original creator, but Jony Ive ? a masterful minimalist – at least when it comes to hardware. Ive?s first touches should be recognized in the iOS 7, which is will likely going to appear sometime this year ? but it is behind schedule.
John Gruber, an Apple enthusiast and an author of the Daring Fireball website apparently managed to get some internal information regarding the new version of the iOS. With shifts inside the company, and having designer and developer teams working more close than ever under the CEO Tim Cook, it seems that even the OS X software engineers have been transferred from work on the OS X 10.9 to the iOS 7. That move is understandable, given the fact that the Worldwide Developer Conference (WWDC) is coming closer with each passing day ? rumored date frame is Monday to Friday (June 10-14) for this year?s conference.
Allegedly, people at Apple are very happy with what both Cook and Jony Ive have done thus far ? but there is much work left, and time is passing by. Gruber notes that the changes are ?system-wide? when it comes to the user interface itself, and that may have been the culprit this time around. Regardless of what cosmetic or core adjustments iOS gets in versions to follow, parts of Forstall?s effort will surely still remain in the platform for some time to come.
Source: Daring Fireball


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The Chatham Islands offer the chance to re-engage with the natural world.
Eight hundred kilometres east of the South Island, the Chatham Islands are part a vast submerged continent known as Zealandia. Around three million years ago, these remote islands were uplifted from the ocean floor. They brought to the surface a fascinating geology of ancient continental rocks, limestone and undersea volcanoes.
With nothing but ocean at every point of the compass, the Chatham Islands are rightly famous for fresh seafood and fascinating marine life. Daily catches of cod, groper, crayfish (lobster) and shellfish take pride of place on local menus. The resident fur seal colonies are easy to visit and passing dolphins and orca can sometimes be seen from the shore.
On the shores of beautiful Te Whanga lagoon, near Blind Jim's Creek, careful fossicking is likely to be rewarded by the discovery of fossilised shark teeth. Around 30 million years old, these teeth are a treasure of the island. Some, from the jaws of prehistoric megaladon, are around 10 centimetres long.
Geographically isolated for millions of years, the Chathams have witnessed the evolution of unique bird and plant species. The Chatham Island black robin is a great conservation success story. Less well-known however are the very rare taiko and shore plover, as well as several endemic species. An outer island albatross colony can be viewed by boat.
The delightful Chatham Island forget-me-not (Myosotidium hortensia) features large blue flower heads that emerge each spring from the glossy dark green leaves. A forest walk near Te Whanga lagoon leads to stands of flowering nikau palms and glades of broadleaf native forest.
While the ocean's influence prevents extreme temperatures, it does bring a passing parade of different types of weather to the islands. In winter, rain wear and thermals will keep you cosy while you're exploring outdoors. For spring and autumn, you'll need lighter clothing - but bring the wet weather gear and thermals just in case! In summer, definitely pack your swimming gear.
In wild weather and calm, roaming the island on foot is a great way to relax and shake off the stresses of modern life. Along with the fascinating cloud patterns and seascapes, there's a special quality to the light in the Chathams which suggests you've found one of the rarest places on Earth.


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Glendale Community CollegeHome Menu
Roster Update
For those of you who did not teach this summer, the rosters are new, different and add new information. I hope you have all visited your 'Faculty Center' and viewed your fall class schedule and class rosters. On each of your class rosters, there is a drop down box entitle 'Enrollment Status'. You can set this to view only fully enrolled students or just wait listed students or all students. You can e-mail each student one at a time or all of them at the same time. I know many faculty used this option during the summer to send their syllabus prior to the start of the term. Please be aware that not all of our current students have activated their College e-mail; Admissions mailed a postcard reminding students that the GCC e-mail is the standard for GCC communications.
Wait lists are set at 25. The wait list works like this: a student fully enrolled drops the course and the first person on the wait list rolls into the class if the prerequisite is met and there is no time conflict or unit overload. The key to the above statement is that a student can put themselves on the wait list without the system checking any rules - the student's eligibility is checked at the time of enrollment. If the next student in line for enrollment does not meet the requirements, that student is passed over and the next student is checked for eligibility.
All wait list students will automatically roll into your class when an opening occurs because of student drop, no show or instructor drop during the first week of the semester. In the second week, you will need to give the wait list student that you want to add to your class, a permission code that is listed at the bottom of your 'drop roster'. The student can use the permission code to add the class on line. All students should be added from the wait list prior to adding any student that contacts you or shows up in your class on the first day of the term.
The drop roster will be available the first day that your class meets.


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Old Massey's Collect the Nicest People!
Hi John,
I have never seen any dates on the cart but I had to buy it when I saw both Verity and MH on the handles. I have seen others but most of the lettering had been worn off years ago, So when did the two companies come together??


text:
Wait, that's the cat. MOVE!!!Ah, here we go! The girls' shopping cart (which they took into the sale because they are just that awesome) and the stack next to it are all romance novels for my students--I'll make them take one and read it and write a paper analyzing it when we study the romance genre later this semester (right now we're on Star Wars--I just tonight had to break it to them that Luke Skywalker was a member of a terrorist organization attempting to overthrow a ruling government. Yes, friends, blowing up the Death Star was an act of terrorism). The romance novels range from the 1940s old-school Harlequins with the duchess who falls in love with the brutal yet passionate czar to the contemporary ones that all seem to revolve around a single woman looking for a father figure for her adorable yet troubled child. Weird.
The girls picked clean the children's area (they got all the awesome geography picture books that nobody wanted to pay for--Tasmania, and Eastern Bloc, and My Mommy was Born in Germany) and then ransacked the young adult shelves for all kinds of inappropriate titles, but I bribed them into letting me sort through their collection and take out the teen heartbreakers by offering them a set of animal encyclopedias, so now we're flush on good animal pictures to cut out and do stuff with.
I got a couple of books to read for real, but mediating my kiddos requires so much energy that I really didn't have time to give the sale a good go-through just for me, so mostly I just grabbed all the halfway-decent crafting books that I saw. I got Needlepoint: The Art of Canvas Embroidery, which I'm not that excited about except that it does have some construction patterns for canvas containers; Better Homes and Gardens Gifts to Make Yourself, which has instructions for making those big cardboard puzzles that little kids like; Sewing The New Classics: Clothes With Easy Style, whose clothes are mostly baggy and ugly but from which I think I can figure out how to make jammy pants; Have a Natural Christmas 1980, from which I am totally going to make some pomanders; and , which has a pattern for bell bottoms(!).
Yep, it took me three trips to the car to drop all this stuff off, while the girls sat on a bench on the sidewalk and spilled chocolate soymilk on themselves (from Bloomington Bagels--don't get me started on how much I hate taking my kids to a restaurant by ourselves, but we were off the grid, and we had to eat!), and then I got yelled at by some guy who'd apparently been waiting on me to leave in my car so he could take my space, but I'm sorry, it's not my job to watch my kids and where I'm going and figure out what the people in other cars are doing, too, and then we went back into the playroom and the girls played while I utilized the library's electricity and wi-fi to write my lesson plans and grade my online homework submissions, and then we left the library, and I was yelled at AGAIN by some woman who got out of her car to come over and ask me if I was leaving my spot because I put one kid in her carseat, then the other kid in her carseat, then got in the car, then got each kid a book, then a different book, then got one kid a snack, then called Matt on the cellphone to see if he knew if the power was back on at home or if I should drive the kids to a restaurant--again, not my job to leave a parking spot as quickly as possible so someone else can have it. Have I ever mentioned that I LOOOOOVE to bike to the library with the girls? Weather willing, that's what we'll be doing again tomorrow morning, because come rain or come shine, storytime comes every Tuesday morning.
When is your storytime?


text:
Share your deals, sales, promo codes, and specials here. We all like saving money.
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All information, analysis, plans, or specifications that disclose the nature, extent, quantity, or degree of air contaminants or other pollution which will be produced by any source which the District requires any applicant to provide before such applicant builds, alters, replaces, operates, sells, rents, or uses such source, are public records.
All air quality or other pollution monitoring data, including data compiled from stationary sources, are public records.
Except as otherwise provided in Section D below, trade secrets are not public records under this Rule. Trade secrets, as used in this Rule, may include, but are not limited to, any formula, plan, process, tool mechanism, compound, procedure, production rate, or compilation of information which is known only to certain individuals within a commercial concern who are using it to fabricate, produce, or compound an article of trade, ,or a service having commercial value and which gives its user an opportunity to obtain a business advantage over competitors who do not know or use it. The owner or operator shall state in writing his justification for claiming material as trade secrets and such justification shall be public record. The Air Pollution Control Officer shall rule on the validity of trade secret claims. Requests from the public for records shall be specific and in sufficient detail to enable the Air Pollution Control Officer to readily identify the information requested.
Notwithstanding any other provisions of the law, all air pollution emission data, including those emission data which constitute trade secrets as defined in Section C above, are public records. Production data used to calculate emission data are not emission data for purposes of this subdivision and data which constitute trade secrets and which are used to calculate emission data are not public records.


text:
Distinctive Singleframe® grille
Progress is never blending in
See how the
Audi Q5
measures up
Inimitable design. Striking performance. Outstanding intelligence. This is how we've redesigned the 2018 Audi Q5. This is why the Q5 stands apart.
Distinctive Singleframe® grille
Three-spoke multifunction steering wheel
Exterior design
Integrated dual exhaust outlets
Sleek power tailgate with hands-free tailgate release


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Utah Probate Records
This entry was originally written by Patricia Lyn Scott, CA and Gary Topping Ph.D. for Red Book: American State, County, and Town Sources.
Probate functions (testate and intestate proceedings; guardianships for males under age twenty-one and females under age eighteen and those incompetent to handle their legal affairs) were shared by county probate courts and territorial district courts between 1852 and 1896. Records for these are generally at the county seat, though some probate records have been microfilmed and are accessible through the FHL and/or the Utah State Archives. Microfilm coverage varies between counties.
After 1896, jurisdiction for probate matters became the sole responsibility of the District Court that operated for the county. There are now eight judicial districts encompassing twenty-nine counties. To determine exactly which district a county belonged to at a particular time there are two finding aids. One is available at the Utah State Archives and the other is a guide that can be obtained by writing the Utah Judicial Council, Administrative Office of the Courts, 450 S. State St., P.O. Box 140241, Salt Lake City, UT 84114-0241, which has an online directory at www.utcourts.gov/committees/index.asp. Since 1 January 1989, all Utah courts were placed under the administration of this office. In trying to determine the county seat that was functioning as the probate court during a particular time period, that office will be the most efficient source.
Currently District 1 includes Box Elder, Cache, and Rich counties; District 2'Davis, Morgan, and Weber; District 3'Salt Lake, Summit, and Tooele; District 4'Juab, Millard, Utah, and Wasatch; District 5'Beaver, Iron, and Washington; District 6'Garfield, Kane, Piute, Sanpete, Sevier, and Wayne; District 7'Carbon, Emery, Grand, and San Juan; and District 8'Daggett, Duchesne, and Uintah.
FamilySearch.org collections available for free online:


text:
Our Bloom wallpaper will add a touch of romance to your space. Each double roll measures 24" wide x 30' long. Digitally printed on top quality, durable, pre-pasted paper for easy installation and removal. Samples are available. Please allow 2-3 business days for shipping. Made in the USA.
Please See Important Notes Below.
Colors - Blush, Sage, Forest Green, Spa Blue, Coral, Gold, Ecru
Horizontal Repeat 24"
Vertical Repeat 15"
**Need help determining how many double rolls you require? We strongly recommend hiring a professional to help you determine how much paper you need. If you would like to try it yourself, see our MEASURING GUIDE. It is very important to order enough paper to complete your project. Our paper is printed in small runs...Should you run out of paper, it is likely that your paper will not be an exact color match.
"This wallpaper is perfect for our laundry room makeover. Love it!" - Erin, Missouri
"Love, love, love the leopards! Looks amazing in our powder room." - Kaitlynne, Atlanta


text:
- Did you mean
- site ocamm file image events composter pdf
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Herbicide Resistance in Waterhemp
multiple-resistant population surviving 2,4-D. Which herbicides is waterhemp resistant to in Ohio? Site 2 (ALS), all ... populations Site 9 (glyphosate), most populations, some in eastern Ohio still sensitive Site 14 (PPO), 30 to ... populations resistant to site 14 are resistant to sites 2 and 9 also Only two POST options for ...
County-level 4-H Advisory Committees
ohio4h.org/volunteers/advisory-committees extension.osu.edu/sites/ext/files/imce/PPHandbook/Extension%20Advisory%20Committee%20guidelines-18 ... 4H-48 4-H Youth Development 12/06/2019 Katherine Feldhues, Extension Educator, 4-H Youth ... evaluating key events and practices found in their county 4-H program. Across the state, 4-H Advisory ...
Consumer Debt Relief in the United States and Canada
HYG-5247 Family and Consumer Sciences 09/09/2019 Cäzilia Loibl, Associate Professor and Extension ... filings in the United States is low. In 2016/2017, about 770,000 U.S. consumers filed non-business or ... million non-business, consumer bankruptcy filings were recorded (United States Courts 2017). In the ...
84 ACEL students named to CFAES Dean's List
List for the 2019 Autumn Semester. To be selected for the Dean's List, a student must earn a 3.5 ...
ACEL Alumni Award Recipients
In 2019, the ACEL Alumni Board established an annual alumni awards program to recognize the ... these awards. Distinguished Alumni Award 2019 John Poulson '81, '87 MS, agricultural education ... Young Alumni Award 2019 Rose Hartschuh '09, agricultural education Kayla Oberstadt '15 MS, ...
Tech Recipe: Starting A Scholastic Drone Racing Team
international drone leagues and major international drone racing events to date (Wikipedia contributors, 2019 ... CDFS-1576 Community Development 12/12/2019 Meghan Thoreau, Extension Educator, Community ... events. Why drones? Scholastic drone teams propel lifelong learners. Student teams encourage and build ...
Utility Scale Solar Development
Productivity with Ground-Based Solar Photovoltaic (PV) Development Ohio Power Siting Board- Solar Farm Map and ... Statistics Ohio Power Siting Board- Standard Application Process Flowchart Presentation Slides- Solar Leasing ... Efficiency Organic Site Preparation Methods Guide to Farming Friendly Solar Argonne National Laboratory- Can ...
Equipment Needed for Planting and Maintaining Food Plots
ANR-82 Agriculture and Natural Resources 12/27/2019 Mark Landefeld, Assistant Professor Emeritus, ...
Planning and Conducting Effective Public Meetings
ccao.org/wp-content/uploads/HDBKCHAP004-2000.pdf Yost, Dave. (2019). Ohio Sunshine Laws–An Open Government Resource Manual. Community community ... CDFS-1555 CDFS-1555-02 Community Development 12/31/2019 Gwynn Stewart, MS, Extension Educator, ... Ohio's Sunshine Laws may require pre-event publicity. According to the Ohio Sunshine Laws manual, every ...
Pigweed Identification Guide
ANR-77 Agriculture and Natural Resources 08/16/2019 Bruce Ackley and Mark Loux, Horticulture and ...


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Bumper sticker leads to Delta deputy firing
Delta County detention deputy Michael Williams showed at work this summer with a political bumper sticker affixed to his car. The sticker reading, "Vote Democrat? You're stuck on stupid," didn't sit well with at least one citizen who noticed the sticker in an employee space at the detention facility parking lot and called Delta County Sheriff Fred McKee to complain.
Sheriff McKee, a Republican, said he asked Williams to park his vehicle elsewhere so the sticker wouldn't be associated with his office. Instead, Williams put blue tape over the offending sticker for a time and continued to park in the sheriff's detention lot.
McKee said he strongly supports First Amendment rights to free speech and he didn't fire the deputy over the sticker. He fired him for insubordination after Williams "wrote me an inappropriate letter."
Williams, who could not be reached for comment, has not taken any further action since his firing three weeks ago. And the sheriff said he has not had any further problems with bumper sticker complaints. McKee said he doesn't plan to institute a no-bumper-sticker policy. He said his office already has a policy that warns employees about bringing discredit on the office.


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Mary Allen Bradley necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 83 diseños de 18 diseñadores freelance.
Bradley Veterinary Housecall Service
I'm a caring and compassionate small animal veterinarian who loves not only animals but people too. I'm starting a housecall practice on beautiful Cape Cod to take the stress out of getting Fido and Fluffy to the doctor. This will also give me more time to spend with the clients instead of rushing them out the door after 15 minutes. It's all about quality of life and quality of care for me and I want to give my clients the service and the tools they need to keep their animals healthy and to help them manage medical issues as they arise. I want to convey that their pets health and happiness matters to me as much as if they were my own animals.
Pet owners, pet lovers
Would love a logo that indicates what the business is w/o necessarily seeing the business name (doesn't everyone want that?). Also conveying compassion would be a huge plus. Please no clip art and please don't use any animals other than dogs or cats. Dogs & cats in a car is out since someone in town already has that logo. No paw prints only logos please. Feel free to use the whole business name and abbreviation. I'm open to just about anything and would like to include the veterinary symbol. I like crisp, clean lines. Have FUN!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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Our very own Ali Fedotowsky joined "Talk Stoop's" Cat Greeleaf on the stoop this past weekend to chat about… well, how great our show is (duh!). Then, Cat got into the juicy stuff that I'm sure has gotten "The Bachelorette" fans paying close attention to. Ali explains why she decided to leave her job at Facebook and go the reality TV route and being in the public eye.
"I'm so much happier now," Ali says. Who wouldn't be? C'mon, working with us is a blast, mainly because our jobs are to travel to the best places in search of the best places to eat shop and play.
Plus, she explains what that tattoo is all about--even we didn't know! Watch the video above for the full interview.
And, don't miss Ali on "1st Look" Saturdays after "Saturday Night Live!"
Related Links


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Celebrating the Shuttle — coming soon
It's been a looong time since I originally posted about a self-initiated project to celebrate the conclusion of NASA's space shuttle program.
Originally I hoped to release a print to coincide with the final mission, but that came and went in July 2011 and I never got the piece to a stage I was happy with.
Anyway, watch this space, because I am pleased to announce that in early 2013 the project will be unveiled. Better late than never! 😉


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Getting through some lost applications...
John R. Putman/B.Scott4England
Age: 19
Lower order LHB/RMF
Bat: 11.13
Bowl: 30.43
Econ: 3.50
Field: 12
Conor A.M. Dasm/conorules
Age: 17 [adj]
Middle order RHB/RM
Bat: 30
Bowl: 26 [adj]
Econ: 2.50 [adj]
Field: 21
Nash R. Chance/Evilhoopler
Age: 28
Lower order RHB/LS
Bat: 28
Bowl: 26
Econ: 3.20
Field: 15
Ben C. Jacobs/Incey
Age: 17
Middle order RHB
Bat: 41 [adj]
Field: 24
Ben Hawker/Fungus
Age: 18
Middle order RHB/OS
Bat: 41
Bowl: 35
Econ: 4
Field: 18
Last edited by Mr Mxyzptlk; 24-05-2009 at 12:20 PM.
Sreesanth said, "Next ball he was beaten and I said, 'is this the King Charles Lara? Who is this impostor, moving around nervously? I should have kept my mouth shut for the next ball - mind you, it was a length ball - Lara just pulled it over the church beyond the boundary! He is a true legend."
What do I do next now that I've officialy registered?
Sign up for club cricket. It's begun already, but there are still vacancies. Apply for one of the vacant positions listed in the thread I've linked. You can also check out the IPL thread if you're interested.
I signed up for this about 3 months ago, but have no idea wether im in a team.
Most likely J Denton.
Im 90% sure I would of been a bowler as well.
Should I just sign up again?
Jason R. Denton
Tail RHB/RF
Age: 17 [adjusted]
Bat: 10
Bowl: 26 [adj]
Econ: 3.00
Field: 21
Cheers man, what do I do now?
See my post above your first post.
Just letting everyone know that I am back. And ready to rip this competition to shreds.
James A. Steele / ledzep
Opener LHB/SLA
Age: 17 [adjusted]
Bat: 36 [adj]
Bowl: 44 [adj]
Econ: 5.5 [adj]
Field: 18
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Select a City
Alpine, WY
Best Farmers' Markets around Alpine, WY
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Blackfoot Farmers Market
97 West Pacific Street
Blackfoot, ID
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Dubois Farmers Market
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Season: Summer July 2019 - October 2019Thursdays, 5PM - 7PM Loation: St. Thomas Episcopal Church Community Room Season: Winter November 2019 - ...
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Farmers Market At The Liberty Square
2475 South Ammon Road
Ammon, ID
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Idaho Falls Farmers' Market
A-D Street
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Jackson, WY
About Us: We invite you to visit the Jackson Hole Farmers Market on Town Square each Saturday during the summer from 8:00 am to 12:00 noon. The fi...
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Jackson Hole People's Market
Cache Street and Snow King Avenue
Jackson, WY
Season: Summer Market Hours: May 29 - September 18, 2019Wednesdays, 4PM - 7PMLocation: Base of Snow King (Cache St. and Snow King Avenue) Season...
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Pinedale Farmer's Market
234-238 Bonneville Street
Pinedale, WY
About Us: The Pinedale Farmer's Market is a "High Altitude" Market. Pinedale sits at 7,175 feet, and is considered growing zones...
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Rexburg Farmer's Market
South College Avenue
Rexburg, ID
Season: Summer Market Hours: May 8 - October 16, 2020Fridays, 4PM - 8PMLocation: South College Avenue in Downtown Rexburg.
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Star Valley Farmers Market
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Season: Summer Market Hours: June 27 - September 12, 2019Thursdays, 4PM - 7PMLocation: Alpine Civic Center
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Mission Statement: To support local farms and growers and the economies of Driggs and Teton Valley. Season: Summer Market Hours: June 5 -...
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text:
Lung cancer starts when
abnormal cells grow out of control in the lung. They can invade nearby tissues
and form tumors. Lung cancer can start anywhere in the lungs and affect any
part of the
respiratory system.
The cancer cells can
spread, or metastasize, to the
lymph nodes and other parts of the body.
Lung cancers are divided into small cell lung cancers (SCLC) and non-small cell lung cancers (NSCLC). Small cell lung cancers usually grow more quickly and are more likely to spread than non-small cell lung cancer.
cancer is the leading cause of cancer deaths in the world.1
Most lung cancer is
caused by smoking.
But sometimes lung cancer develops in people who have never smoked.
Being exposed to
secondhand smoke, arsenic, asbestos, radioactive dust, or
radon can increase your chances of getting lung
cancer. People who are exposed to radiation at work or elsewhere have a higher
chance of getting lung cancer.
The first
signs of lung cancer may include:
Because these symptoms are so general, many people don't suspect lung cancer. And by the time they see a doctor, often the cancer has already started to spread.
If the cancer spreads within and beyond the chest, other symptoms may occur.
Your symptoms and your medical history—especially if you have any history of cancer in your family—will help your doctor decide how likely it is
that you have lung cancer and whether you need tests to be sure.
Lung cancer is usually first found on a chest
X-ray or a
CT scan. More tests are done to find out what kind of
cancer cells you have and whether they have spread beyond your lung. These
tests help your doctor and you find out what
stage the cancer is in. The stage is a rating to
measure how big the cancer is and how far it has spread.
Treatment for lung cancer may
include surgery, chemotherapy,
radiation, or a combination of these therapies. Targeted therapy and laser therapy may also be used.
Few lung
cancers are found in the early stages when treatment is most effective. When lung cancer is found before it has spread outside the lungs, about half of these people will live at least 5 more years.2 After lung cancer has spread outside the lungs, how long a person lives usually depends on how far the cancer has spread (the stage) by the time it is found.
Finding out that you have cancer can change your life. You may feel like your world has turned upside down and you have lost all control. Talking with family, friends, or a counselor can really help. Ask your doctor about support groups. Or call the American Cancer Society (1-800-227-2345) or visit its website at www.cancer.org.
Lung cancer that is caused by smoking can be prevented.
So it is important to stop smoking—or to stop being around someone else's
Even if you have smoked a long time, quitting can lower
your chances of getting cancer. If you already have lung cancer, quitting makes
your treatment work better and can help you live longer.
Learning about lung cancer:
Being diagnosed:
Getting treatment:
Ongoing concerns:
Living with lung cancer:
Supportive care:
Health Tools help you make wise health decisions or take action to improve your health.
More than 8 out of 10 lung
cancers are caused by smoking.3 Tobacco smoke contains carcinogens—substances that cause cancer. These substances damage lung cells, and over time the damaged cells can turn into lung cancer.
The more you smoke and the longer you have smoked, the higher your chances of getting lung cancer. You lower your chances when you quit or cut down on how much you smoke.
A few people get lung cancer after being exposed to other
harmful substances, including
asbestos, radioactive dust,
radon, or radiation such as X-rays.
Cancer also may be caused by gene changes (mutations) that occur as you get older.
Symptoms of lung cancer may include:
When lung cancer spreads, there may be other
symptoms. For example, if it spreads to the spine or
bones, it may cause pain in the back or other bones or cause weakness in the arms or
legs. If it spreads to the brain, it may cause seizures, headaches, or vision
Lung cancer can start anywhere in the lungs and may affect any
part of the
respiratory system. This can cause breathing or heart problems, such as:
As lung cancer grows, it may spread (metastasize) to other
parts of the body. Lung cancer is classified in
stages, which describe how far the cancer has grown and spread.
long-term outcome (prognosis) for lung cancer depends
on how much the cancer has grown and spread.
A risk factor for lung cancer is something that increases your chance of getting this cancer. Having one or more of these risk factors can make it more likely that you will get lung cancer. But it doesn't mean that you will definitely get it. And many people who get lung cancer don't have any of these risk factors.
About 85 out of 100 lung cancers are related to cigarette smoking.4 Smoking cigars or a pipe may also increase your risk for lung cancer.
Your risk of getting lung cancer increases:
Quitting smoking lowers your risk for getting cancer, and your risk keeps going down as
long as you don't smoke. Even cutting down how much you smoke may reduce your
risk (but not as much as quitting completely).
If you live with a smoker, you have a higher risk for
lung cancer compared with a person who lives in a nonsmoking
For more information, see the topic Quitting Smoking.
Exposure to some substances may increase your risk for lung cancer, including:
Some gene changes (mutations) can increase the risk of getting lung cancer. These gene changes mostly occur as a person gets older.
Call 911 or other emergency services immediately if you:
Call your doctor immediately if you have:
Call your doctor to find out when an evaluation is needed
if you:
Health professionals who can evaluate your symptoms
and your risk for lung cancer include:
Health professionals who can evaluate and treat your lung
cancer include:
To prepare for your appointment, see the topic Making the Most of Your Appointment.
Your doctor will first do a physical exam and ask about your medical history to find out your risk for lung cancer and look for any lung problems. The exam may include a chest X-ray and blood test.
If your exam suggests that you may have lung cancer, your doctor may recommend other
tests, such as:
After lung cancer has been diagnosed, testing
is done to find out whether the cancer has spread (metastasized) to other
organs in your body and to determine the
stage of the cancer.
Tests include:
If you have non-small cell lung cancer, your doctor may check for tumor markers (biomarkers), such as EGFR, ALK, and KRAS, that are caused by gene changes (mutations) in cancer cells. This can help your doctor choose the treatment that will
work best for you.
A person whose lungs aren't working well may not be a good
candidate for surgery. If surgery to remove cancer in all or part of a lung is being
considered, the following tests may be done:
Screening tests help your doctor look for a certain disease or condition before any symptoms appear. This can increase your chance of finding the problem at a more treatable stage. Studies have not yet shown that routine screening for lung cancer saves lives or prevents lung cancer.
Screening may help people whose risk for lung cancer is higher than normal. Talk to your doctor about the pros and cons of screening tests if you:
Several studies have looked at the use of
chest X-rays, sputum cytologies, or
spiral CT to screen for lung cancer. Screening with chest X-rays or sputum didn't improve survival. But a large research study found that screening with low-dose spiral CT reduced lung cancer deaths among current and former smokers.6 Screening with low-dose CT scans may help if you are older than 55 and are a heavy smoker.7
While screening tests may aid in the early diagnosis of lung
cancer, they can also show abnormal findings, such as nodules, that
are not cancer. This is known as a false-positive, which can cause you to have more tests or even treatment that you don't need.
Treatment for both non-small cell lung
cancer (NSCLC) and small cell lung cancer (SCLC) may include the following:
Other treatments for NSCLC include:
Your doctor may check for tumor markers (biomarkers), such as EGFR, ALK, and KRAS, that are caused by gene changes (mutations) in cancer cells. This can help your doctor choose the treatment that will
work best for you.
Other treatments for SCLC include:
The kind of treatment and the
long-term outcome of
lung cancer depends on the
type and stage of the cancer and also on your age and your overall health.
Some treatments can cause side effects. Home treatment
measures may help.
Your quality of life is critical when you are considering your treatment choices.
Discuss your personal preferences with your
oncologist when he or she recommends treatment.
Additional information about lung cancer is provided by the National Cancer Institute at www.cancer.gov/cancertopics/types/lung.
If you have been recently diagnosed with lung cancer, you may feel
denial, anger, and grief. Reactions vary from person to person. Talk to your doctor about steps you can take to help with your
emotional reactions.
If you are having a hard time moving forward with your life, talk
with your doctor. Your cancer treatment center may offer counseling services.
You may also contact your local chapter of the American Cancer Society to help
you find a support group.
Having cancer can change your life in many ways. For support in managing these changes, see the topic
Getting Support When You Have Cancer.
After initial treatment for
lung cancer, it is important to receive follow-up
You may be
interested in participating in research studies called
clinical trials. Clinical trials are based on the most
up-to-date information and are designed to find better ways to treat people who
have cancer.
People who do not want standard treatments or are not cured by
standard treatments may want to participate in clinical trials. These are
ongoing in most parts of the United States and in some other countries around
the world for all stages of lung cancer.
Cancer treatment has two main goals: curing cancer and making your quality of life as good as possible. Palliative care can improve your quality of life by helping you manage your symptoms. It also can help you with other concerns that you may have when you're living with a serious illness.
One study of people with non-small cell lung cancer who started palliative care when they were diagnosed with lung cancer found that they not only felt better but also lived a little longer than the people who didn't have palliative care.8
For some people who have advanced cancer, a time comes when treatment to cure cancer no longer seems like a good choice. This can be because the side effects, time, and costs of treatment are greater than the promise of cure or relief. But this isn't the end of treatment. You and your doctor can decide when you may be ready for hospice care.
It can be hard to decide when to stop treatment to prolong your life and shift the focus to end-of-life care.
To learn about supportive care, see:
Most lung cancers are caused by smoking. If
you use tobacco, you can help prevent lung cancer by quitting. For more information, see
the topic
Quitting Smoking.
You may be able to make other changes in your life that can help prevent lung cancer:
Studies show that taking supplements of beta carotene or vitamin E does not affect the risk of lung cancer for non-smokers. But for smokers, especially those who smoke one or more packs a day, taking beta carotene supplements can actually increase their risk for lung cancer.9
During treatment for any stage of
lung cancer, there are steps you can take at home to manage some symptoms and side effects. Be sure to follow any instructions your doctor has given you.
Other issues you may be able to handle at home include:
If you smoke and have lung cancer, quitting smoking
will make your treatment more effective and may help you live longer. Smoking
delays healing after surgery, so you may have a better recovery from lung
cancer surgery if you have quit smoking.
People with early-stage lung cancer
who continue to smoke during radiation therapy have been shown to have shorter
survival times than those who do not smoke.10
Smoking may
also make chemotherapy less effective. The nicotine in tobacco seems to help
the cancer cells and their blood supply multiply while also protecting the
cancer cells from destruction.11
For information and
help quitting smoking, see the topic
Quitting Smoking.
Medicines for lung cancer mainly involve chemotherapy. Other medicines may be used to help with pain.
Chemotherapy is the most effective treatment for
small cell lung cancer. It can help control the growth and spread of the
cancer, but it cures lung cancer in only a small number of people. It
also may be used to treat more advanced stages of
non-small cell lung cancer.
Chemotherapy is called a systemic
treatment because the medicines enter your bloodstream, travel through your
body, and kill cancer cells both inside and outside the lung area. Some
chemotherapy drugs are taken by mouth (orally), while others are injected into
a vein (intravenous, or IV).
Some of the more common chemotherapy medicines used for lung cancer include the
Most chemotherapy causes some
side effects. Your doctor may prescribe
medicines to control nausea or vomiting.
You may be concerned about losing your hair
from cancer treatment. Not all chemotherapy medicines cause hair loss, and some
people have only mild thinning that is noticeable only to them. Talk to your
doctor about whether hair loss is an expected side effect of the medicines you
will receive.
Chemotherapy may be combined with surgery. It may be given before or after surgery to kill cancer cells.
Pain is one of the main concerns of people who have cancer. But cancer pain can almost always be controlled with medicines and other options. Medicines used for cancer pain include prescribed medicines, such as hydrocodone or morphine, or nonprescription medicines, such as aspirin and similar drugs.
Lung surgery to remove
the cancer may be an option when your cancer is in only one lung or present in
one lung and in nearby lymph nodes. It usually is done only if your doctor
thinks all the cancer can be removed and your general health is good enough for
you to handle the surgery.
Nearby lymph nodes may also be removed to find out whether the cancer has
The type of surgery performed depends on the location and
size of your lung cancer:
The side effects from surgery will depend on the type of surgery that you have. There is less pain with surgery that is minimally invasive (VATS) than the traditional surgery (thoracotomy). You may have numbness and tingling in the chest area. This usually goes away in a few weeks or months.
Radiation treatment is the use of
high-energy X-rays to kill cancer cells and shrink tumors. Most radiation for lung cancer is given externally, which means that the radiation comes from a machine outside the body.
Radiation is often used in combination with
surgery or chemotherapy or both. But it may be used alone if surgery is not possible.
People who can't have surgery may have a special type of radiation called stereotactic radiosurgery (SRS). This isn't surgery but a series of very high doses of radiation that are aimed at the cancer. SRS is usually given to treat tumors that have spread to the brain. SRS may also be called gamma knife radiosurgery, cyberknife, stereotactic ablative radiotherapy (SABR), or stereotactic body radiotherapy (SBRT).
Radiation may be used to prevent small
lung cancer from growing in your brain. This is called
prophylactic cranial irradiation (PCI).
Radiation also may be used as
palliative care to:
Radiation may cause
side effects, such as skin changes, fatigue, and trouble swallowing.
People sometimes use complementary treatments along with medical treatment to help relieve symptoms and side effects of cancer treatments. Some of the complementary therapies that may be helpful include:
These mind-body treatments may help you feel better. They can make it easier to cope with treatment. They also may reduce chronic low back pain, joint pain, headaches, and pain from treatments.
Before you try a complementary therapy, talk to your doctor about the possible value and potential side effects. Let your doctor know if you are already using any such therapies. They are not meant to take the place of standard medical treatment.
The American Cancer Society (ACS) conducts educational
programs and offers many services to people with cancer and to their families.
Staff at the toll-free number have information about services and activities
in local areas and can provide referrals to local ACS divisions.
The American Lung Association provides programs of
education, community service, and advocacy. Some of the topics available
include asthma, tobacco control, emphysema, infectious disease, asbestos, carbon monoxide, radon,
and ozone.
The American Thoracic Society provides information for
professionals and consumers about the prevention and treatment of lung
diseases. Its website provides educational materials for the consumer.
Cancer.Net is the information website of the American
Society of Clinical Oncology (ASCO) for people living with cancer and for those
who care for them. ASCO is the world's leading professional organization
representing physicians of all oncology subspecialties. Cancer.Net provides
current oncologist-approved information on living with cancer.
The National Cancer Institute (NCI) is a U.S. government
agency that provides up-to-date information about the prevention, detection,
and treatment of cancer. NCI also offers supportive care to people who have cancer
and to their families. NCI information is also available to doctors, nurses,
and other health professionals. NCI provides the latest information about
clinical trials. The Cancer Information Service, a service of NCI, has trained
staff members available to answer questions and send free publications.
Spanish-speaking staff members are also available.
CitationsSilverstri GA, Jett JR (2010). Clinical aspects of lung cancer. In R Mason et al., eds., Murray and Nadel's Textbook of Respiratory Medicine, 5th ed., vol. 2, pp. 1116–1144. Philadelphia: Saunders.American Cancer Society (2012). Cancer Facts and Figures 2012. Atlanta: American Cancer Society. Available online.Ettinger DS (2012). Lung cancer and other pulmonary neoplasms. In L Goldman, A Shafer, eds., Goldman's Cecil Medicine, 24th ed., pp. 1264–1272. Philadelphia: Saunders.U.S. Department of Health and Human Services (2010). A Report of the Surgeon General: How Tobacco Smoke Causes Disease—The Biology and Behavioral Basis for Smoking-Attributable Disease Fact Sheet. Available online: http://www.surgeongeneral.gov/library/tobaccosmoke/factsheet.html.Aldington S, et al. (2008). Cannabis use and risk of lung cancer: A case-control study. European Respiratory Journal, 31(2): 280–286.Cornett PA, Dea TO (2012). Cancer. In SJ McPhee, MA Papadakis, eds., 2012 Current Medical Diagnosis and Treatment, 51st ed., pp. 1548–1614. New York: McGraw-Hill.National Comprehensive Cancer Network (2012). Non-Small Cell Lung Cancer, version 2.2012. Available online.Temel JS, et al. (2010). Early palliative care for patients with metastatic non–small-cell lung cancer. New England Journal of Medicine, 363(8): 733–742.National Cancer Institute (2011). Small Cell Lung Cancer PDQ: Treatment—Patient Version. Available online: http://www.cancer.gov/cancertopics/pdq/treatment/small-cell-lung/Patient.Fox JL, et al. (2004). The effect of smoking status on survival following radiation therapy for non–small cell lung cancer. Lung Cancer, 44(3): 287–293.Dasgupta P, et al. (2006). Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proceedings of the National Academy of Sciences, 103(16): 6332–6337.Other Works ConsultedBedient JF, Schwartz DA (2011). Occupational and environmental lung diseases. In EG Nabel, ed., ACP Medicine, section 14, chap. 18. Hamilton, ON: BC Decker.National Cancer Institute (2011). Small Cell Lung Cancer PDQ: Treatment—Patient Version. Available online: http://www.cancer.gov/cancertopics/pdq/treatment/small-cell-lung/Patient.National Cancer Institute (2012). Non-Small Cell Lung Cancer PDQ: Treatment—Patient Version. Available online.National Cancer Institute (2012). Small Cell Lung Cancer PDQ: Treatment—Health Professional Version. Available online: http://www.cancer.gov/cancertopics/pdq/treatment/small-cell-lung/healthprofessional.Neville NJ, Kuruvilla MS (2010). Lung cancer, search date October 2009. Online version of BMJ Clinical Evidence. Also available online: http://www.clinicalevidence.com.Strickler J, Crawford J (2011). Lung cancer. In EG Nabel, ed., ACP Medicine, section 12, chap. 8. Hamilton, ON: BC Decker.
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Last Revised:
September 12, 2012
Healthwise Staff
Medical Review:
E. Gregory Thompson, MD - Internal Medicine & Michael Seth Rabin, MD - Medical Oncology
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2020 Media
Living within a faith community like First Presbyterian Church means worshipping, growing together in faith and fellowship with the global body of Christ. In today's digital age, FPC is blessed to be able to serve the wider community with both televised broadcasts, online live streaming and online video and audio recordings. Home-bound members and prospective visitors regularly take advantage of these resources, and even friends overseas in Africa often tune in to online streaming from the Tulsa International Fellowship.
"When I first came, I felt like I already knew the church because I had listened to the sermons online. Walking in here, it did feel like home!" FPC worshipper Vicky Wilcoxen


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You have received your first commercial deal! If you are like most of the brokers I've counseled lately your story is probably similar to the one below:
What does the average "money broker" ( I prefer to use the term capital consultant) do? First, the want to know the loan amount and then they quickly tack on 1-5 points (they assure me they are never greedy) and then they take an executive summary and shoot it around the internet asking lenders if they can close this loan in 14-21 days!
These brokers are not taking the correct actions. They are simply planning to fail. Why? They are ignoring the proven strategies used by seasoned commercial brokers.
Want to know the "Secret"?
Before you submit any loan proposal to any lender, you must find out:
The number of deals that lender has closed in the past, and how many they intend to close in the current year.
This is critical to your success! And how do you find out? ASK! Ask the lender by phone or email if they are looking for this type of loan and at the amount your borrower requires. If it is a medical office building ask them how many of these have they closed? And how many do they intend to close this year?
You want to hear: "Oh, we did many of these loans last year and we intend to do many this year!" Don't send your prime office building to a lender that's seeking to fund retail centers!
Find lenders and develop a personal relationship with them. Find out what their sweet spot is. In summary, Never submit a loan deal to any lender unless you are able to verify that the lender has closed many of the specific types of deals that your are seeking funding for and that they are currently actively lending.
Seasoned commercial brokers have honed their lender relationships over the years. You can begin this week by contacting at least one lender and interviewing them. At the end of one year you could easily have 52 lenders that you've developed a file on and what their lending parameters and preferred property types are.
One year from now you too can be a seasoned "Power Broker".
To your Success!