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The American League prospect 'Dream Team'
Rangers, Twins, Astros and Royals have multiple representatives on squad
When I began to think of the American League prospect "Dream Team," I immediately considered the wealth of talent at shortstop. Any one of four players could have made my starting lineup.
When I get to that position, I am going to name those who are in the conversation to be the finest prospect shortstop in the AL. A case can be made for any of the four.
Like the National League, the AL positions are either feast or famine. Some are stronger in depth than others.
One thing is clear in reviewing all prospects: The top pitching and shortstop farmhands in the Pipeline point the way toward an exciting future for baseball.
Catcher: Jorge Alfaro, Rangers, 20
Alfaro is one of the most athletic and talented catchers I have seen since Salvador Perez of the Royals. Alfaro reminds me of Perez, having the ability to hit and play great defense with a cannon for an arm.
First Base: C.J. Cron, Angels, 24
I had the pleasure of watching Cron in the Arizona Fall League. He has improved tremendously at the plate. Cron's power will always play, but his plate discipline is what will help drive a solid batting average.
Note: Watch out for Jesus Aguilar, 23, of the Indians. He could burst on the scene with power at some point in 2014.
Second Base: Mookie Betts, Red Sox, 21
Betts is a pure athlete. He has the misfortunate of slotting behind Dustin Pedroia in the Red Sox organization. However, places are always found for guys that are grinders. That's Betts.
Shortstop: Carlos Correa, Astros, 19
I think Correa is going to have a phenomenal career. He may outgrow shortstop. Correa makes everything look so easy. A complete player, he has to be seen to be appreciated. Correa is a "wow" guy.
Any of these shortstops could have made my Dream Team:
Xander Bogaerts, Red Sox, 21
Addison Russell, Athletics, 20
Francisco Lindor, Indians, 20
Third Base: Miguel Sano, Twins, 20
The sky is the limit for this powerful guy, but I have concerns about his home park. Target Field is a tough place to hit. But Sano will dig his way through.
Outfield: Byron Buxton, Twins, 20
Buxton is a complete player with five tools that show in almost every game he plays. He's the type of guy a team can build around. Buxton will hit the Target Field gaps and play outstanding defense. He runs well, too.
Outfield: George Springer, Astros, 24
Springer has a big swing, and he may miss a lot of pitches. But when he connects, I've seen the damage. Springer can be lethal. Astros fans will love him.
Outfield: Michael Choice, Rangers, 24
Choice is underrated in my book. I've seen the power. Once he becomes more selective and learns how to hit big league pitching with a greater confidence and comfort level, he will turn some heads with that power -- especially in his home park with Texas.
Pitcher: Taijuan Walker, Mariners, 21
Walker should make the rotation this season. Safeco Field is a great place for him. Look for Walker's confidence to build as the season progresses, as he has a big, big arm.
Pitcher: Mark Appel, Astros, 22
Appel comes home to Houston to build his career. He has some work to do on command, but the repertoire is there. Appel just needs some refinement.
Pitcher: Aaron Sanchez, Blue Jays, 21
Sanchez has all the pitches but needs to repeat his delivery to get the most from his ability. If he gets out of sync, he has to recover quickly. I love Sanchez's mound demeanor and stuff.
Pitcher: Kyle Zimmer, Royals, 22
Zimmer could easily become the best of the lot with the movement on his pitches. If he throws strikes consistently, his ceiling is top-of-the-rotation, All-Star-quality starter.
Pitcher: Yordano Ventura, Royals, 22
Ventura has one of the power arms that just won't quit. If he can find the plate with consistency, he can win plenty of games. I'd like to see Ventura bring the 97 mph heater down a bit to get more movement.
And now, my Major League Baseball Prospect Dream Team (both leagues):
Catcher: Austin Hedges, Padres
First Base: Cron, Angels
Second Base: Kolten Wong, Cardinals
Shortstop: Correa, Astros
Third Base: Sano, Twins
Designated Hitter: Javier Baez, Cubs
Outfield: Oscar Taveras, Cardinals
Outfield: Buxton, Twins
Outfield: Springer, Astros
Pitcher: Archie Bradley, D-backs
Pitcher: Noah Syndergaard, Mets
Pitcher: Walker, Mariners
Pitcher: Jamison Taillon, Pirates
Pitcher: Appel, Astros


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Ontario doctors ratify deal that will cut costs, change some services
TORONTO — Ontario doctors have endorsed a new deal with the province that will see some services scaled back and others modernized in order to find savings.
The Ontario Medical Association says the agreement was accepted by 81 per cent of the nearly 21,000 doctors who voted by phone or online.
The OMA says the deal, worth $11.1-billion a year, will trim spending by $400 million through a half a per cent payment cut for all doctors while "modernizing" how services are delivered.
But Health Minister Deb Matthews has said total payments to physicians will rise by $100 million as new doctors are brought on, an increase that will be offset by cost savings.
The changes to services include shortening the length of time of annual physicals and the number of tests done on healthy adult patients.
The OMA says the agreement, effective from last Oct. 1 until March 31, 2014, will pump new money into house calls to seniors and high-need patients.
It also says the deal announced Sunday will let patients speak to doctors more easily through "e-consultations."
A tentative agreement was reached last month after the two sides returned to the bargaining table following a dispute this year over regulatory changes to cut Ontario Health Insurance Plan fees and premiums.
The deal shows doctors can work with the Liberal government as it moves to tame the deficit, said OMA President Dr. Doug Weir.
"Ontario's doctors demonstrated tremendous leadership by being active partners in helping the province with its fiscal challenges," he said in a release.
"If we are going to build on our successes in recent years to improve health care in Ontario, doctors and government need to continue to work in partnership."
Matthews called the ratification an "important milestone" for the province's health care system.
"Ontario's doctors have demonstrated real leadership today. They worked with us to find creative solutions under challenging fiscal circumstances," she said in a statement.
"This agreement marks a renewed era of partnership with doctors as we work together to transform and sustain our precious health care system."

subset: commoncrawl


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Mplus Discussion
Categorical Data Modeling
Thomas Klausch
posted on Sunday, April 29, 2012 - 1:12 pm
I am comparing several randomized groups which were asked the same questions with different measurement techniques. I am trying to establish where the different techniques cause measurement bias using ordinal CFA models. There is a lot of debate between forward vs. backward testing procedures. My main question is about whether it is necessary to constrain thresholds to be equal across all groups (techniques) when assessing scale invariance.
In a forward selection procedure I would first assess loadings, while thresholds are free, then constrain loadings. Say I find thresholds are not equivalent; is it then still admissible to free thresholds as necessary and go on testing equality hypotheses on errors, factor variances (or in short: item reliability)?
In backward selection procedures I would constrain loadings and thresholds. Say thresholds are actually biased. Is it then admissible to first assess scale invariance regarding loadings and errors/factor variances (i.e. item reliabilities), even though the thresholds are wrongfully constrained to equal each other (and hence the constrained model lacks fit)?
My general worry is that if thresholds are free, group difference in constrained error or factor variance may be 'absorbed' by the free thresholds. I observe this in some of my analyses. On the other hand, if thresholds are wrongfully constrained, I wonder if tests of equality might get biased. -- Thanks
Bengt O. Muthen
posted on Sunday, April 29, 2012 - 1:45 pm
It's an interesting question and the answer depends on how general the IRT (categorical factor analysis) model is that you want to use.
Standard IRT does not have the generality of Mplus in allowing residual variances to be different across groups (fixing them to 1 in a reference group). Allowing the residual variances to be group-varying seems like a realistic need judging by multiple-group experience with continuous outcomes.
If you allow this flexibility using either Delta or Theta parameterization, the model with invariant loadings but non-invariant thresholds is not identified. This is different from the case of continuous outcomes. With categorical outcomes, a change in the residual variances (or the scale factors) can be absorbed by the group-specific factor variances and the group-specific thresholds.
The model with invariant loadings but non-invariant thresholds is identified when one specifies invariant residual variances (fixed at 1 using the Theta parameterization). So in that case one can study group differences in the factor (co-)variance. But I wonder if one can realistically assume from a substantive point of view that one is measuring the same factor in groups that have different thresholds.
This is why I tend to want to test invariance with respect to thresholds and loadings jointly when I work with categorical items. If you have reason to believe that thresholds are likely not invariant, I would try a modified version of threshold invariance such as what I mentioned earlier with a non-invariant item intercept and invariant thresholds.
In Version 7 there is also a Bayesian approach that builds on the "BSEM" paper on our web site, allowing small, ignorable non-invariance, where significant non-invariance can be detected for all parameters of all items in a single run.
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U.S. Women's Update - Feb. 23
Bill Kauffman
Manager, Media Relations and Publications
Phone: 719-228-6800
E-Mail: firstname.lastname@example.com
COLORADO SPRINGS, Colo. (Feb. 23, 2010) – The current U.S. Women's National Team Weekly update released on Feb. 23 includes briefs on U.S. players competing overseas, player information, Volley-Tweets, trivia questions and much more.
For the complete PDF version including a complete list of players training at the team's facility at American Sports Centers in Anaheim, the U.S. international transfer list, 2009 season stats and other fan interaction sections, click here.
TRIVIA QUESTIONS: 1. Which current member of the U.S. Women's National Team earned Best Receiver at the 2002 NORCECA Girls' Youth Championship and played in the 2002 NORCECA Women's Junior Championship the same year? 2. Which member of the U.S. Women's National Team earned Best Server at the 2004 NORCECA Girls' Youth Continental Championship? 3. Which player was part of both the 2001 and 2002 U.S. Women's Junior National Team? Answers can be found on page four in the full PDF version of the current U.S. Women's National Team Weekly update.
NATIONAL TEAM OPEN TRYOUTS A SUCCESS: For three days this past weekend, nearly 175 athletes were put to the test by U.S. Women's National Volleyball Team Head Coach Hugh McCutcheon (Christchurch, New Zealand) at the squad's open tryouts held Feb. 19-21 at the U.S. Olympic Training Center in Colorado Springs. At the end of the weekend, McCutcheon was happy with what he saw on the court after each player had four different training sessions. "I thought the tryout was successful," McCutcheon said. "It was wonderfully well-attended. There were a lot of great volleyball players in the gym all at the same time for us to evaluate. The tryout involved 174 athletes – the most ever at the annual open tryout – being evaluated by McCutcheon (Christchurch, New Zealand) and assistant coaches Karch Kiraly (San Clemente, Calif.) and Jamie Morrison (Dana Point, Calif.). The coaching staff was able evaluate 46 middle blockers, 41 outside hitters, 38 liberos, 30 setters and 19 opposites representing 81 different colleges. Athletes were competing for spots on the U.S. Women's Volleyball National Team program and the U.S. Women's Senior A2 teams. The U.S. Women's National Team program is open to athletes who have concluded their college eligibility and who wish to train full-time. This program could begin as early as February 2010, or when an athlete's scholastic or professional club season has concluded. Athletes who will have remaining collegiate eligibility may still participate in the program with participation beginning May 2010 or when their scholastic calendar ends. Athletes in college with collegiate eligibility remaining for the 2010 season and not selected to the USA Women's National Team may be invited to participate in the USA Senior A2 Team. This program is tentatively scheduled to take place in Phoenix from May 24 through June 2. A projected 24 athletes will be invited to participate in the program, which will include training and competition in the 2010 USA Adult Open Championships in the Open Division from May 29-June 1. USA Volleyball considers the event as the National Championship for the sport of volleyball in the United States. "The amount of talent and support that the colleges have provided bodes well for the U.S. Women's National Team program," McCutcheon said. According to Tom Pingel, USA Volleyball's managing director of Indoor High Performance Program, the U.S. Women's National A2 Teams will be announced in mid-March once all confirmations to participate have been secured. For the tryout roster and full press release, click here.
NATIONAL TEAM OPEN TRYOUTS PHOTO GALLERIES: Three photo galleries – 476 images – of the U.S. Women's National Team Open Tryouts can be found online. For the Feb. 19 gallery of 144 images, click here. For the Feb. 20 gallery of 223 images, click here. For the Feb. 21 gallery of 109 images, click here.
OTHER STORIES FROM THE OPEN TRYOUTS: Read two other stories posted to USAVolleyball.org in relation to the U.S. Women's National Team Open Tryouts held Feb. 19-21. Blair Brown (Purcellville, Va.), a rising senior opposite hitter at Penn State University, has helped the Nittany Lions to an unprecedented three consecutive NCAA Division I Women's Volleyball Championship titles. Yet, she is not resting on those laurels while attending the U.S. Women's National Volleyball Team open tryouts being held Feb. 19-21 at the U.S. Olympic Training Center in Colorado Springs. For the full story, click here. Growing up in Colorado Springs in the hometown of the U.S. Olympic Training Center, Rachael Broerman dreamed of the opportunity to play on the U.S. Women's National Volleyball Team. Despite a microfracture of her left knee last fall and two ACL surgeries before graduating from high school, Broerman continues to defy the odds. For the full feature, click here.
U.S. WOMEN SHOW SUPPORT FOR TEAM USA AT WINTER OLYMPICS: Members of the U.S. Women's National Team wore their red, white and blue at the OC Sports Grill in Anaheim on Feb. 21 in support of Team USA hockey players as it defeated Team Canada 5-3 during the Vancouver 2010 Winter Olympic Games. The U.S. Women's National Volleyball Team trains at the USA National Team Center located within the American Sports Centers in Anaheim. The City of Anaheim is also home to the Anaheim Ducks of the National Hockey League, which has several players representing the two Olympic hockey teams. Members of the Anaheim-based U.S. National Volleyball Teams scheduled to be in attendance at the OC Sports Grill included: Bryn Kehoe (North Bend, Ohio), Lauren Paolini (Ann Arbor, Mich.), Foluke Akinradewo (Plantation, Fla.), Christa Harmotto (Aliquippa, Pa.). In addition, several players training with the U.S. Men's National Team attended the event, including Hudson Bates (Richmond, Va.), Matt Werle,(Meadville, Pa.), Jake Schkud (Santa Monica, Calif.), Mark Ribeiro II (New York, N.Y.) and Jonathan Charette (Fullerton, Calif.).
UPDATE TO SECOND TRAINING SESSION ROSTER: A total of 17 players are currently training with the U.S. Women's National Team during its second winter training block that ends April 9. Neticia Enesi, a middle blocker who completed her collegiate career last fall at the University of Oregon, started training at the USA National Team Center on Feb. 22. The team training sessions, held at the American Sports Centers in Anaheim, Calif., are open to the public. Training times are generally Monday through Thursday from 9 a.m. to 12:30 p.m., while Fridays often vary on times. Middle blockers include Tracy Stalls (Denver, Colo.), Christa Harmotto (Aliquippa, Pa.), Alexis Crimes (Rancho Cucamonga, Calif.), Cheryl Weaver (Washington, D.C.), Mekana Barnes (Highlands Ranch, Colo.), Brittnee Cooper (Houston) and Neticia Enesi (The Dallas, Ore.). Outside hitters/opposite include Heather Hughes (Fallbrook, Calif.), Angie Pressey (Lake Mary, Fla.), Brittany Moore (Orange, Calif.) and Jill Collymore (Bellevue, Wash.). The setters training include Bryn Kehoe (North Bend, Ohio) and Nicole Vargas (Seal Beach, Calif.). The libero position has Jessica Fine (Tarzana, Calif.) and Tamari Miyashiro (Kaneohe, Hawaii) training with the U.S. Women's National Team. Further, Foluke Akinradewo (Plantation, Fla.), and Lauren Paolini (Ann Arbor, Mich.) have joined the training session. Some players could leave for pro opportunities or other circumstances, while the training group could expand at the end February following the U.S. Women's National Team Open Tryouts set for Feb. 19-21 at the U.S. Olympic Training Center in Colorado Springs.
INTERNATIONAL TRANSFERS: For a full listing of the 146 international transfers for American female players to other countries to play professional volleyball, visit the full PDF version of the U.S. Women's National Team Weekly Update.
METCALF PROVIDING OFFENSE IN BRAZIL: Nancy Metcalf (Hull, Iowa), a member of the 2004 U.S. Olympic Games roster, is in Brazil playing for Usiminas/Minas of the Brazilian Superliga. Metcalf totaled 18 points in pacing Usiminas to a 25-8, 25-13, 25-20 victory over Pauta on Feb. 17. She tallied 13 kills on 25 attempts, two blocks and an ace in the victory. Against Cativa on Feb. 19, Metcalf was credited with a match-high 26 points via 23 kills on 44 swings and an ace. Now 4-0 in the second phase and 11-5 overall in the Brazilian Superliga, Usiminas plays Sollys on Feb. 25 and Pinheiros on Feb. 27 in its next league matches.
BERG PUSHING ITALIAN TEAM TO TOP: Lindsey Berg (Honolulu), a setter on the 2008 U.S. Olympic Team which won the silver medal in Beijing, is playing for MC-Carnaghi Villa Cortese of the Italian Serie A professional league this winter. Berg set Villa Cortese to a 27-25, 21-25, 25-20, 25-15 victory over Chateau d'Ax Urbino Volley on Feb. 21. She tallied a kills on three attempts to go with a block for two points. Berg helped Villa Cortese to a 52 kill percent and .417 hitting efficiency for the match with only 12 errors. Villa Cortese, now 13-4 on the season and in second place with 38 points, challenges RebecchiLupa Piacenza on Feb. 27 in its next Serie A match. To follow Berg throughout the season, check out her blog at lindseyberg.blogspot.com.
BOWN COMPETING FOR JESI: Heather Bown (Yorba Linda,Calif.), a three-time Olympian with the U.S. Women's National Team, is competing for Monte Schiavo Banca Marche Jesi in the Italian Serie A professional league. Bown turned in nine kills on 15 errorless swings in a 25-22, 25-20, 25-15 Jesi victory over Asystel Volley Novara on Feb. 21. She added a match-high five blocks – more than Novara as a team – for a total of 14 points in the match. With the victory, Jesi improves to 11-6 on the season and is in fourth place with 33 points, just one point out of third place. Jesi returns to the court on Feb. 28 against Riso Scotti Pavia.
TOM, ASYSTEL VOLLEY NOVARA: Logan Tom (Salt Lake City, Utah), a three-time Olympian and member of the 2008 U.S. Olympic Games silver medal roster, is competing for Asystel Volley Novara in the Italian Serie A professional league this winter. Tom scored a match-high 21 points in leading Novara to a 25-18, 25-17, 25-20 victory over Poland's Enion Energia Dabrowa Gornicza on Feb. 16 in the second match of the CEV Indesit Champions League Playoff 12 round. She tallied 18 kills on 31 swings with three blocks. With the victory, Novara swept the home-and-home series to advance to the Playoff 6 round against Turkey's VakifGunes Telekom Istanbul. The Playoff 6 round starts the first week of March with Novara playing its Playoff 6 opponent on March 2. Later in the week, Novara dropped a 25-22, 25-20, 25-15 match to Monte Schiavo Banca Marche Jesi on Feb. 21. Tom scored 10 kills and a block in the loss. Novara, which is currently in eighth place in the Serie A division with 22 points and an 8-9 record, will play Scavolini Pesaro on Feb. 28.
RICHARDS, SYKORA HELPING OMICHKA TO RUSSIAN FOREFRONT: Kristin Richards (Orem, Utah), an outside hitter and 2008 U.S. Olympic Team alternate, and three-time U.S. Olympian Stacy Sykora (Burleson, Texas) are playing in the Russia Super League with Omichka in Omsk. Richards scored 24 points for Omichka on Feb. 21 in a 25-22, 25-18, 27-29, 25-20 victory over Dinamo-Krasnodar. She tallied 22 kills on 48 swings, along with two aces and 15 errorless service receptions. Sykora handled 40 of the team's 81 service receptions with a 68 positive reception percent. Omichka, in second place with a 13-4 record and 30 points, takes on Russia Super League leader and undefeated Dinamo-Moscow (16-0) on Feb. 26 in its next league match.
LARSON PUSHING DINAMO KAZAN TO NEW HEIGHTS: Jordan Larson (Hooper, Neb.) is playing in her first professional season of her career in the Russia Superliga with Dinamo Kazan. Larson helped Kazan to a near upset of undefeated Dinamo Moscow on Feb. 21. Dinamo Moscow, now 16-0 with a four-match lead over second-place Omichka, prevailed 27-25, 25-19, 18-25, 20-25, 15-13. Kazan, which dropped to 8-9 on the season with 25 points for sixth place, takes on 11th-place Leningradka on Feb. 28 in its next match.
FAWCETT SCORING IN RUSSIA: Nicole Fawcett (Zanesfield, Ohio), a U.S. Women's National Team player, continues to pay dividends for Dinamo-Yantar after joining the team in mid-season. Fawcett produced 22 kills on 38 swings, two aces and a block for Yantar on Feb. 20, but it was not enough as Uralochka battled to a 25-23, 25-18, 32-34, 25-22 victory. Yantar is now 7-10 on the season with 24 points for eighth place. Fawcett's team hits the court again on March 1 against 10th-place University-Technolog of Belgorod.
BARBOZA WITH TORAY IN JAPAN: Cynthia Barboza (Long Beach, Calif.), an outside hitter with the U.S. Women's National Team and alternate on both the 2004 and 2008 Olympic Games rosters, is playing in her first professional volleyball season in Japan V-League with Toray. Barboza contributed seven kills on 23 swings in Toray's 25-23, 23-25, 25-19, 25-22 loss to NEC on Feb. 20. Toray bounced back to sweep Okayama 25-19, 26-24, 25-20 on Feb. 21 as Barboza chipped in eight kills on 21 swings and two blocks for 10 points. Toray, now 13-7 on the season and in third place, travels to Aichi on Feb. 27 and Feb. 28 for matches against seventh-place Pioneer and eighth-place Toyota Auto Body. To read her most recent blog, click here.
NNAMANI, GLASS PACING PROSTEJOV IN CZECH REPUBLIC: Ogonna Nnamani (Bloomington, Ill.) and Kim Glass (Lancaster, Pa.) continue to lead their Czech Republic professional team Prostejov. The squad concluded its regular season with a 20-0 record. In its CEV Indesit Champions League Playoff 12 round match against Italy's Scavolini Pesaro on Feb. 18, Prostejov lost 25-18, 25-18, 25-20 in the second match of the home-and-home series. Nnamani led her squad with 18 points with 17 kills on 33 swings with just two errors. She added a block in the loss. Glass scored seven kills on 13 swings while adding a block and a service reception of 56 percent excellent on a team-high 32 attempts. Last week, Prostejov defeated Brno to capture the Czech Cup. Starting on Feb. 24, Prostejov begins the Slovakian-Czech Cup with each round being best of five and the finals held in April.
JOINES TAMAS, BUSSE WITH TOA BAJA: Jen Joines Tamas (Milpitas, Calif.) and Cassie Busse (Prior Lake, Minn.), both members of the U.S. Women's National Team, are playing for 2009 Puerto Rico League champion Toa Baja in 2010. Busse scored 11 points with seven kills, three blocks and an ace in helping the Llaneras to a 25-18, 25-23, 25-20 victory over Carolina on Feb. 17. Jennifer Tamas added nine points in the victory. Four days later, Toa Baja held off Mayaguez 25-16, 18-25, 25-18, 18-25, 19-17. Tamas tallied 10 points with six kills, two blocks and two aces. Busse pocketed six kills in the victory, while 2004 AVCA Division I Co-Player of the Year Stacey Gordon of Canada tallied 19 points in the win. Toa Baja is currently in second place with a 3-1 record with its only loss to Catano, the only undefeated team in the league.
THOMPSON, SALVO WITH CATANO: Courtney Thompson (Kent, Wash.), a setter with the U.S. Women's National Team, and Airial Salvo (Farmington, Utah) are playing for Catano de Lancheras of the Puerto Rico Superliga. Thompson tallied nine assists, 12 digs and two points in leading the Lancheras to a 25-14, 25-22, 25-12 victory over Ponce on Feb. 17. Salvo scored a match-high 19 points for Catano against Ponce. Thompson set Catano to its fourth straight victory to open the season with a 25-19, 25-15, 38-36 victory over Juncos on Feb. 21. Thompson had two aces and a block in the victory. Salvo was credited with 16 points and 16 digs in the victory. Catano extended its win streak to five matches with a hard-fought 26-24, 25-23, 26-24 victory over Corozal on Feb. 22. Thompson had 10 assists, 10 digs and two aces in the victory. Salvo added eight kills, 19 digs and 12 receptions.
SPICER WITH PONCE: Nellie Spicer (Barrington, Ill.), a setter with the U.S. Women's National Team, is competing for Ponce of the Puerto Rico Superliga in 2010. Spicer totaled 15 assists and 12 digs on Feb. 17 against Catano, but it was not enough in a three-set loss. She helped Leonas to a 25-22, 25-23, 22-25, 25-23 victory over Guaynabo on Feb. 21. Spicer scored three kills and three aces in the victory while adding 18 digs and 10 assists. She set Sonja Newcombe to a massive 38-point performance in the win.
KIMMICH WITH GUAYNABO: Katie Wilkins Kimmich (Lakeside, Calif.), an outside hitter with the U.S. Women's National Team, is competing for the Mets of Guaynabo in the Puerto Rico Superliga. She scored a team-high 15 points with 14 kills and 17 digs in Guaynabo's four-set loss to Juncos on Feb. 17. Kimmich scored 20 points with 18 kills and two blocks on Feb. 21, but it was not enough as Ponce earned a 25-22, 25-23, 22-25, 25-23 victory. One day later, she put up impressive numbers again versus Mayaguez in an 25-18, 25-21, 19-25, 19-25, 15-10 loss. Kimmich tallied 21 points with 19 kills and 13 receptions in the contest.
OTHER AMERICAN HIGHLIGHTS IN PUERTO RICO: Caguas' Shonda Cole scored 27 points in a five-set loss to Mayaguez on Feb. 16…Erin Moore tallied 16 points and Christal Morrison added 12 in Bayamon's sweep of Corozal on Feb. 16. Corozal was led by Kaitlin Sather's 14 points…Erica Lott charted 29 points and 16 digs for Juncos in its four-set win over Guaynabo on Feb. 17. Kelly Wing added 16 points and 12 digs in the victory. Aneli Cubi-Otineru recorded 10 points for Guaynabo…Jessica Jones produced 10 points in Carolina's three-set loss to defending champion Toa Baja on Feb. 17, while former U.S. Women's National Team member Katie Olsovsky charted seven points for Carolina…Sarah Ammerman scored six points for Ponce in a three-set loss to Catano on Feb. 17. Shonda Cole hammered out 23 points with 19 kills, three blocks and an ace to lead Caguas to a four-set victory over Bayamon on Feb. 21. Christal Morrison and Erin Moore each scored 11 points in the loss…Katie Olsovsky tallied 14 points and Jessica Jones added 13 in leading Carolina to a four-set victory over Corozal on Feb. 21. Kristee Porter notched a match-high 19 points in the loss, while Kaitlin Sather added 17 points…Kelly Wing collected 15 points and Erica Lott added nine points in a three-set Juncos loss to undefeated Catano on Feb. 21…Sonja Newcombe provided Ponce 38 points by herself in leading the Leonas to a four-set victory over Guaynabo on Feb. 21. Sarah Ammerman added 12 points in the victory…Katie Olsovsky, a past U.S. National Team member, and Jessica Jones provided a balanced offensive Carolina team with 14 points apiece as the Las Gigantes edged Caguas in five sets on Feb. 22. On the other side of the net, Shonda Cole tallied 18 kills and five blocks for 23 points to go with 12 digs in the loss…Kristee Porter scored a match-high 18 points for Corozal on Feb. 22, but league-leader Catano edged the visitors in three straight deuce sets (26-24, 25-23, 26-24). Kaitlin Sather added 14 points in the loss...Aneli Cubi-Otineru provided 14 points in Guaynabo's five-set loss to Mayaguez on Feb. 22.
TRIVIA ANSWERS: 1. Cynthia Barboza; 2. Alisha Glass; Kim Glass


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This week dangerous smog caused one of northeastern China's biggest cities to be shut down by the government. Changhua Wu, our Greater China Director suggests this is a warning to Chinese and international leaders to take urgent action towards tacking climate change, weeks before COP19 begins in Warsaw, Poland.
It is recommended that an index measurement of PM2.5 (or particulate matter) should not rise above 300, because toxicity at this level in the atmosphere is extremely dangerous to human beings. Yet in Harbin, a city in the northeastern Chinese province of Heilongjiang, last Monday it hit 1,000.
Around 11 million people live in Harbin. The new reading immediately affected all of these people. Visibility was reduced to 10 meters. Public transport, roads, airports, schools and shops were closed.
But while the blanket of smog has begun to lift now, the cloudy dialogue around dangerous pollution levels aggravated by climate change remains.
Air quality has been a growing concern for China's leadership, with pollution a key issue from the very first day China's new leaders were officially appointed, but crises such as the past week's smog in Harbin should spur this dialogue into urgent action.
Practice shows that for real improvements to be made by our government in environmental quality, we need the full participation of the general public. And with these now regular pollution headlines and the obvious spotlight on human health effects, this is firmly a public issue.
It is imperative that government and businesses respond to the public demand that something is done about our cities' pollution problems. Reducing and mitigating the impacts of pollution on human health should certainly be central to any government action. But leaders must also account for economic impacts - to minimize productivity damage and economic losses - because these have associated social issues too. The overriding impetus to act also comes from China's economic growth: rapid urbanization, population growth and urban land scarcity will further accelerate pollution and its health hazards.
Where should the government begin in this urgent task? Of course tackling sources of pollution in individual cities is very important, but China's fossil fuel-based energy structure is the country's largest source of air pollution. So in order to effectively address the wide-spread pollution challenge in China, a fundamental shift from our heavy reliance on coal to clean energy must happen. Removal of subsidies to fossil fuels must simultaneously be examined and implemented in China in the very near future.
The country has already made some great strides in the areas of environment and clean energy. In Beijing, our recently launched Clean Air Plan looks like it could raise the threshold of environmental protection and tackle the city's pollution, if we act on this plan now.
I also applaud the recent intensive actions taken by the municipal government to adopt a more integrated approach to tackle the PM 2.5 challenge through its control of vehicular pollution - one of the biggest priorities for the city of Beijing in addressing its notorious air pollution.
But in some areas we are stalling. Despite new subsidies, the electric vehicle industrial sector in China continues to face some technological barriers to overcome before scale up. Infrastructure to accommodate EV charging remains at the piloting stages. To address those barriers, sharing and learning from other countries' experiences is critical. China must more actively reach out to other countries for collaboration.
Thankfully, China is collaborating internationally already, with landmark announcements made on reducing HFCs with the US and cooperation on green growth with the EU.
And nationally, there is clear policy direction under China's 12th Five-Year Plan, on energy saving, emission reduction and industrial development. In line with the major reform of financial and fiscal policy and mechanism, innovation and strong incentives could be expected in mobilizing capital flows towards China's green growth.
While it may be a long and difficult road to invest fully in clean energy, when we acquire the joint efforts of all countries, and focus on addressing issues of great public concern such as pollution, we will achieve great progress.
As we approach COP19 in Warsaw, China's leaders must set out to show real leadership on climate change.
It is time for China to wake up from the smog, and act!
Read more from Changhua's blog


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Strangeloop necesitaba un nuevo diseño de banner publicitario y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 134 diseños de 27 diseñadores freelance.
We are a dynamic tech company that, while small, is emerging as a thought leader in the web acceleration industry. We develop and sell solutions that are designed to make websites faster.
We recently launched Site Optimizer, a family of solutions that are designed to make websites dramatically faster. Site Optimizer has already been implemented by some high-profile companies, and we're getting a lot of attention in the mainstream tech media. This is the time for us to brand our solutions and hit the ground running.
Brand Name
We sell to other businesses. Our audience is largely made up of business executives, marketing people, developers and IT pros.
3 Banner Ads
- Dimensions: each banner ad 330 x 80 px
- The banners may look similar, but not identical.
- Each banner must have a button for users to click. The button should stand out and look like a button.
- Please use only the text below.
- Please incorporate the logo somewhere in the ad. Our logo must be subtle, the text and the button should be the main attraction in the ad. Logo attached.
- Final file format: PSD
- The ads will be placed on pages like this: http://www.alexa.com/siteinfo/google.com. Please make the ads stand out on this page, but also fit the design aesthetic of the page.
Ad 1: Text & Button
Is your site fast enough?
1-second delay = 7% loss in conversions
Ad 2: Text & Button
Do you know how fast your site REALLY is?
See it through your visitors' eyes.
Ad 3: Text & Button
If your site doesn't load in 3 seconds, it's not fast enough.


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- 2 beds
- 2 baths
- $7,190,000 price
- 2629510 listing id
- Square Feet: 2,074 sqft
- Year Built: 2016
- Neighborhood: Flatiron District
This gracious two bedroom, two bath residence features a corner living/dining room surrounded by floor-to-ceiling windows showcasing stunning river-to-river and Midtown skyline views. The kitchen features marble countertops and backsplash, Nanz hardware, Sub-Zero and Miele appliances, custom-designed cabinetry by Molteni including high gloss white lacquer upper cabinetry and framed solid white oak lower cabinetry. Adjacent to the kitchen, a solid-oak paneled wet bar with marble countertop and Sub-Zero wine refrigerator compliments the space. The corner, southwest facing Master Bedroom Suite includes a large walk-in closet, five fixture master bath and abundant natural light. Bathrooms feature a handsome selection of marbles, custom wood vanities, recessed medicine cabinets, inset shower and tub niches, and Waterworks fixtures. Residences include 4-pipe fan coil HVAC systems and Kraus home automation systems.
The residences at Madison Square Park Tower are perfectly positioned in one of the most iconic and culturally sophisticated neighborhoods in Manhattan- the Flatiron District at Madison Square Park. Transforming the downtown skyline, the soaring tower is a sculptural glass silhouette standing at sixty-five stories rising seven hundred and seventy seven feet in the sky. The striking exterior, crafted by the world-renowned architectural firm Kohn Pedersen Fox Associates, wraps around modern, elegant interiors designed by the celebrated Martin Brudnizki Design Studio.
The tower features a 75-foot-wide granite base that fits harmoniously within the tree-lined block and marks a sense of arrival before ascending to eighty-three residences. Floor-to-ceiling windows offer a dramatic cityscape that includes the Empire State Building, Chrysler Building, the clock tower at 1 Madison Avenue, World Trade Center, the Hudson and East Rivers, and Madison Square and Gramercy Parks.
The collection of amenities throughout five floors consists of a fitness center with boxing and private training suite, golf simulator, basketball court, childrens playroom, library, billiards, cards room, terrace with outdoor grill, and two gracious entertaining spaces including a fifty-fourth floor lounge.Closings Begin This Summer.
Courtesy of: Douglas Elliman 936 Broadway
Office Phone: 212.598.3199
Listing Agent: Fredrik Eklund
Updated: 1st April, 2020 5:38 PM.
45 East 22nd St New York, NY


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Ornate bow-frame amputation saw, 1601-1700
The right tool for the job
British Sign Language description
Audio description
Surgery in the past, surgery today
Surgery is probably no longer the most feared medical procedure. Many of us will go under the surgeon's knife at some point in our lives. We have come to think of surgery as a safe, painless and reliable method to cure us from illness, but this was not always the case. With no pain control and the risk of infection, surgery used to be painful, horrific and dangerous in roughly equal measure and many people died on the operating table. It was usually the last resort for both patient and practitioner.
Early surgery in the Neolithic and Egyptian periods
The earliest form of surgery was trephining, which involved cutting a small round hole in the head. It was practised as early as the Neolithic period, for reasons that remain a mystery. There are many theories about the reasons behind this practice. The only thing we know for sure is that some patients survived the procedure, and sometimes even had more than one performed. Later, the Egyptians practised trephining in an effort to cure migraines - the idea was to 'let out' the illness that was causing the headaches.
The discovery of new materials and their effects on Greek surgery
The Ancient Greeks benefited from new materials, such as iron, which they used to make surgical instruments. Greek surgeons could set broken bones, bleed patients, perform amputations and drain the lungs of anyone unfortunate enough to catch pneumonia. Despite this the dangers associated with surgery meant that it remained the last resort, even for notable doctors such as Hippocrates.
The influence of the Greeks and war on Roman surgery
Romans surgeons had ample opportunity to pick up surgical skills at the infamous gladiator schools and during the many wars that Rome inflicted on its neighbours and others further afield. Their surgical instruments were similar to those employed by the Greeks. Turpentine and pitch were used as antiseptics, but internal surgery was still considered too risky. The Romans also performed amputations, trephining and eye surgery. The most famous surgeon in Rome was Galen, who was surgeon to the Roman emperor.
Al-Zahrawi and Islamic influence on Western medicine
Al-Zahrawi (Albucasis), the famous Islamic surgeon and physician, was highly influential from around 900 CE. He wrote several books detailing subjects such as orthopaedics, military surgery and ear, nose and throat surgery. His books were used extensively for many centuries by Islamic and Western medical scholars.
Surgeons, women, antiseptics and anaesthetics in the Middle Ages
Bleeding was still common in the Middle Ages, but the lack of effective antiseptics and anaesthetics continued to limit the scope of surgery. Some simple anaesthetics such as herbs and alcohol were in use, but they were often so strong that they could kill the patient while the surgeon was still sharpening his or her knife. Women could not become physicians at this time, but surgery, considered a lesser profession, was open to them. Surgeons did not go to university to study, but were apprenticed to practising surgeons to learn through observation.
Medieval barber-surgeons and war
But many surgeons were not surgeons in the modern sense. In fact, most were barbers, who combined small surgical operations with performing bloodletting and tooth extraction. In the medieval period, barber-surgeons travelled around the country. They would take up residence in a castle, treat the occupants and also care for any soldiers who were injured in the many small battles that were undertaken between rival factions.
Paré and new methods of surgery in the 1500s and 1600s
From the 1500s to the middle of the 1600s surgeons experimented with new methods. Cauterising wounds was still popular and helped prevent infection, but some surgeons rejected these established methods in favour of more innovative approaches. In the mid-1500s Ambroise Paré, a French war surgeon, popularised the use of ligatures to control bleeding after amputation. He also used bandages to cover wounds.
The decline of women surgeons
Women continued to train as surgeons throughout the 1500s and 1600s, often treating the poor. In fact they were not pushed out of surgical practice until the 1700s, when surgical training moved to the universities - from which they were banned.
The experience of surgery with newly found pain relief
In the early 1800s the most important talents a surgeon could possess were speed and accuracy. Surgeons were famed for their speed, particularly in amputation. As there was still no effective anaesthetic, they had to perform their procedures quickly and were limited to external tumours, amputation and trephining. The development of new anaesthetic gases changed the experience of surgery for patient and surgeon. With the patient rendered unconscious, surgery could become more invasive and this also gave the surgeon the opportunity to be both slower and more methodical. The anaesthetic gas ether was first used in 1846 but was soon replaced by chloroform, which was originally used to relieve the pain of childbirth.
Killing and preventing germs: surgical developments in the 1800s and 1900s
The development of germ theory provided understanding of how to prevent post-surgical infection. In 1867 Joseph Lister published a paper in The Lancet detailing his method of controlling infection by spraying a mist of carbolic acid over the wound and then wrapping it in carbolic-soaked bandages. This method of killing all known germs was called antisepsis. It was followed in the 1900s by asepsis, which prevented any bacteria from coming into contact with the wound. These twin developments revolutionised surgery.
Improved surgery in the 1940s
By the beginning of the 1900s surgery was usually less painful and risky, but many patients continued to die from internal infection and blood loss. It was not until the development of safe blood transfusion and antibiotics such as penicillin in the early 1940s that surgery became relatively safe.
Specialist surgeons
X-rays also allowed surgeons to plan their surgery effectively by allowing them to see exactly what was wrong. Safer gases and intravenous anaesthetics replaced chloroform, and surgery became more specialised - surgeons spent many years studying a speciality, such as orthopaedics or cardiac surgery.
Complex surgery from the 1900s
As the 1900s progressed, surgery became more complex. Transplant and replacement surgery become relatively common. Elective surgery - non-life-saving procedures - is now performed regularly and some surgery has been developed principally for cosmetic purposes. Keyhole surgery and microsurgery are used increasingly to minimise exposure to infection and reduce the shock of surgery. While surgery has become safer, it remains a risky business.
Related Themes and Topics
Related Objects
There are 538 related objects. View all related objects
Related links
Techniques and Technologies:
R Cooter, Surgery and Society in Peace and War, Orthopaedics and the Organisation of Medicine 1880-1948 (London: Macmillan, 1993)
L Davis (ed.), Fifty Years of Surgical Progress 1905-1955 (Chicago: The Franklin H. Martin Memorial Foundation, 1955)
J Duffin, History of Medicine: A Scandalously Short Introduction (Toronto: University Press, 1999)
H Ellis, A History of Surgery (London: Greenwich Medical Media, 2001)
J Le Fanu, The Rise and Fall of Modern Medicine (London: Little and Brown, 1999)
S H Greenblatt, (ed.), A History of Neurosurgery (Parkridge, IL: The American Association of Neurological Surgeons, 1997)
R Holmes, Scanty Particulars: The Life of Dr James Barry (London: Viking, 2002)
L Klenerman (ed.), The Evolution of Orthopaedic Surgery (London: Royal Society of Medicine Press, 2002)
C Lawrence (ed.), Medical Theory, Surgical Practice: Studies in the History of Surgery (London: Routledge, 1992)
C Lawrence and T Treasure, `Surgeons' in R Cooter and J V Pickstone (eds), Companion to Medicine in the Twentieth Century (London: Routledge, 2003)
R Porter, The Greatest Benefit to Mankind (London: HarperCollins, 1997)
F G Slaughter, The New Science of Surgery (London: Sampson Low Marston & Co Ltd, 1956)
Inflammation of the lungs caused by bacteria. The air sacs (alveoli) become filled with inflammatory cells and the lungs eventually become solid.
A chemical that destroys or holds back the growth of bacteria and harmful micro-organisms. It can be used to cleanse skin wounds and treat some internal infections if it is sufficiently non-toxic.
Using a hot iron to seal a wound to stop bleeding.
A thread or string for tying the blood vessels, particularly the arteries, to prevent bleeding. The word 'ligature' can also refer to the action or result of binding or tying, e.g. the ligature of an artery.
The practice of using antiseptic drugs to eliminate harmful micro-organisms.
Micro-organisms which can cause disease but have an important role in global ecology.
A wave of electromagnetic radiation that has high energy and short wavelength. It is able to pass through many materials, except those of high density such as metals or bones. Discovered in 1895 by William Roentgen.
The branch of medicine concerned with the preservation and restoration of the muscular and skeletal systems in the body.
Reconstructive surgery on small body parts. Microsurgery is performed under magnification using delicate instruments and precise techniques.


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It Is All About BTC, LTC, ETH, ZEC mining as well as other alternative crypto currencies
Today comes another very interesting announcement coming from Coinbase that will help the adoption of Bitcoin as an alternative form of payment for products and services. They have partnered with Intuit's QuickBooks Online to offer PayByCoin, a new service that will enable small businesses to accept bitcoin payments.
How does it work?
– Small business operators register with Coinbase and link their bitcoin wallet to their QuickBooks Online account.
– When a customer receives an invoice, they now have the option to pay by bitcoin, in addition to existing methods such as credit cards and bank transfers.
– Intuit does not currently charge a fee for this new service. Coinbase does not charge any fees for the first $1,000,000 USD in bitcoin transactions; after that, a 1% payment processing fee with be charged when converting bitcoin to USD.
Just last year, Intuit processed approximately $40 billion USD in payments and by making bitcoin payment an option for the 624000 small businesses using QuickBooks Online this can significantly help in the mainstream adoption of Bitcoin as an alternative form of payment.
– For more information on the Bitcoin integration you can visit Intuit's PayByCoin page here…


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Deep Patel
October 17, 2016
Published by
Deep Patel
October 17, 2016
Reduce your errors with medical coding services
Medical billing and coding is an extremely demanding job and is slowly catching the fancy of many. Those who work in this field would know that […]
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BoardridersGuide.com is a family run business established in 1990. BoardridersGuide.com is one of the UK's largest and most established surf, snow and skate websites.
Visit our store to quiz our expert, trained staff who are always happy to help
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We're eager to provide financing for your new or pre-owned vehicle. All types of credit, from good to bad, can qualify for an auto loan. Ron Tonkin Chevrolet has many strong relationships with lenders and is committed to finding you the perfect car loan to suit your car finance needs.
Low interest car loans are also available for customers with existing loans. We can help you refinance your car loan or adjust the term of the contract.
You're just a step away from approved car financing!


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Cotton Standards Websites
The purpose of standards is to create a universal system for measuring cotton fiber and product quality. Standards are a business tool, and in many cases, standards are a strategic for developing new global markets. Standards ensure trade by eliminating trade barriers, saving companies money, and by accelerating research. There are standard ways that value is measured and assessed to products. Many inspection, certification and approval systems are based on global standards. When we say global standardization, we are after measurement transparency: how we measure it and units that are understood globally. Some of the organizations in which Cotton Incorporated participates are listed below. Also listed are regulatory agencies which have textile-specific rules that must be followed.
Standards Organizations
AATCC is the world's leading not-for-profit association serving textile professionals since 1921. AATCC is headquartered in Research Triangle Park, N.C., USA, providing test method development, quality control materials, and professional networking for thousands of members in 60 countries throughout the world.
AATCC test methods are developed by research committees through extensive investigations and interlaboratory comparisons, often taking several years of work. Simplicity, reproducibility, applicability, cost of performing the test, and the time required to perform the test are all important considerations in each development. The content of many AATCC methods form the basis of equivalent ISO methods.
As the voice of the U.S. standards and conformity assessment system, the American National Standards Institute (ANSI) empowers its members and constituents to strengthen the U.S. marketplace position in the global economy while helping to assure the safety and health of consumers and the protection of the environment.
The American Society of Agricultural and Biological Engineers is an educational and scientific organization dedicated to the advancement of engineering applicable to agricultural, food, and biological systems. Founded in 1907 and headquartered in St. Joseph, Michigan, ASABE comprises 9,000 members in more than 100 countries.
ASTM International, formerly known as the American Society for Testing and Materials (ASTM), is a globally recognized leader in the development and delivery of international voluntary consensus standards. Today, some 12,000 ASTM standards are used around the world to improve product quality, enhance safety, facilitate market access and trade, and build consumer confidence.
ASTM Committee D13 on Textiles was formed in 1914. D13 meets twice a year, in January and June, with approximately 200 members attending three days of technical meetings. The Committee has 561 members and currently has jurisdiction of 364 standards, published in the Annual Book of ASTM Standards, Volumes 7.01 and 7.02.
Standardization of:
- fibers, yarns, threads, cords, rope, cloth and other fabricated textile materials; and the methods of test, terminology and definitions relating thereto;
- textile industry raw materials, auxiliaries and chemical products required for processing and testing;
- specifications for textile products.
ISO (International Organization for Standardization) is the world's largest developer and publisher of International Standards. ISO is a network of the national standards institutes of 160 countries, one member per country, with a Central Secretariat in Geneva, Switzerland, that coordinates the system. ISO is a non-governmental organization that forms a bridge between the public and private sectors. On the one hand, many of its member institutes are part of the governmental structure of their countries, or are mandated by their government. On the other hand, other members have their roots uniquely in the private sector, having been set up by national partnerships of industry associations.
Regulatory Agencies
The U.S. Consumer Product Safety Commission is charged with protecting the public from unreasonable risks of injury or death from thousands of types of consumer products under the agency's jurisdiction. The CPSC is committed to protecting consumers and families from products that pose a fire, electrical, chemical, or mechanical hazard or can injure children. The CPSC's work to ensure the safety of consumer products – such as toys, cribs, power tools, cigarette lighters, and household chemicals – contributed significantly to the 30 percent decline in the rate of deaths and injuries associated with consumer products over the past 30 years.
On May 14, 1973, the responsibilities of the Federal Trade Commission for enforcement of the Flammable Fabrics Act, as amended (15 U.S.C. 1191–1204), were transferred to the Consumer Product Safety Commission pursuant to section 30(b) of the Consumer Product Safety Act (Pub. L. 92–573), 86 Stat. 1231 (15 U.S.C. 2079(b)).
Textile, wool, fur, apparel, and leather matters
Care label means a permanent label or tag, containing regular care information and instructions, that is attached or affixed in such a manner that it will not become separated from the product and will remain legible during the useful life of the product.
The term Act means the Textile Fiber Products Identification Act (approved September 2, 1958, 85th Congress, 2d Sess.; 15 U.S.C. 70, 72 Stat. 1717). (b) The terms rule, rules, regulations, and rules and regulations mean the rules and regulations prescribed by the Commission pursuant to section 7(c) of the Act.
Industry Groups
This Restricted Substances List (RSL) was created by a special working group of the American Apparel & Footwear Association's (AAFA) Environmental Task Force. The RSL is intended to provide apparel and footwear companies with information related to regulations and laws that restrict or ban certain chemicals and substances in finished home textile, apparel, and footwear products around the world.
Approved by the Joint Cotton Industry Bale Packaging Committee (JCIBPC), these specifications are intended for use as manufacturing guidelines, and are designed to improve the quality and protection of the cotton bale and to improve the appearance and marketability of the American cotton bale in domestic and foreign markets.
The Sustainable Apparel Coalition is a group of global apparel and footwear companies, associated members of the supply chain, academics, and environmental and social non-profit organizations who recognized that addressing the industry's current social and environmental challenges are both a business imperative and an opportunity. The Coalition seeks to lead a shared vision of industry supply chain sustainability through the creation and use of the Higg Index. In measuring and evaluating apparel and footwear product sustainability performance through the Higg Index, the Coalition aims to spotlight priorities for action and opportunities for technological innovation.
The Sustainability Consortium is an organization of diverse global participants working to make the world more sustainable through better products, services and consumption. We develop and promote science and integrated tools so that together we can improve informed decision making for product sustainability throughout the entire product lifecycle across all relevant consumer goods sectors.


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vExmY0 brauchte ein neues Website Design und hat einen Wettbewerb auf 99designs gestartet.
Aus 17 Designs von 9 Designern wurde eine Gewinner gewählt.
Need a website to grab the attention of rap/hip-hop community and people interested working with us. Total creative freedom here! Will provide detailed direction of what we want.
The Microphone Sessions
Listen up designers! We have a great project for you! =)
Here is what we need:
Really need a page that captures both hip hop and music world and those we want to get invested in our work!
The following wireframe layout mockups are merely a description of where we would like to go with the content/features of the site. Let me re-iterate this point: These wireframe mockups should not be used in the design process of your entries! The wireframes are the features that the website will offer.
- http://www.iersolutions.com/uploads…cation.png
- http://www.iersolutions.com/uploads…chives.png
- http://www.iersolutions.com/uploads…s/blog.png
- http://www.iersolutions.com/uploads…tactus.png
- http://www.iersolutions.com/uploads…forums.png
- http://www.iersolutions.com/uploads…mepage.png
- http://www.iersolutions.com/uploads…/links.png
- http://www.iersolutions.com/uploads…stream.png
- http://www.iersolutions.com/uploads…s/news.png
- http://www.iersolutions.com/uploads…rofile.png
- http://www.iersolutions.com/uploads…stream.png
- http://www.iersolutions.com/uploads…static.png
- http://www.iersolutions.com/uploads…/store.png
- http://www.iersolutions.com/uploads…ions.pngWe also showed the client a few template monster mockups and this is
what they liked about a few designs. Again, these serve a
reinforcement in design direction.comments/ designs locations:
- I think for artists at least have a less corporate feel. I want
artists to want to look at the page but also want to be able to
navigate easily.- http://www.iersolutions.com/uploads…ate_7.jpg- On 8 I like the big square to the left because we can feature our people there and it's kinda in your face.
- http://www.iersolutions.com/uploads…ate_8.jpg- I think the best use of space and getting the featured items (band
photo, top downloads and bio) to stand out is #8. We may want to change
the position of some of the items, like moving "news and events" to the
bottom. I like the grimmy look and feel of it. I think sticking to the
authenticity of what Mic Sessions is, is important. Going too corporate
may alienate the true end-user audience we are trying to capture.
- Use the following logo in your design.- http://www.iersolutions.com/uploads…s_logo.png
- None of the wireframe mockups from the description! They are simply reinforce design direction.


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CPGB-ML and Red Youth comrades, as well as members of the Stalin Society, laid wreaths at the Soviet War memorial in South London today, to mark Victory Day. Following the Nazi invasion of the Soviet Union, in August 1941, after enduring great privation and destruction at the hands of the invaders, the Soviet people checked … Continue reading CPGB-ML Pay tribute at the Soviet War Memorial, on the 70th Anniversary of the Victory over Fascism!
Today - 9 May 2015 - marks the 70th Anniversary of the victory of the Soviet Union over Nazi German Fascism; when the red flag was raised over the Reichstag by the victorious Red Army, while Adolf Hitler committed suicide in his bunker in Berlin. These are achievements of Socialism that we can and should … Continue reading Celebrate Soviet Victory over Fascism!


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Charles C. Southerland Jr. D.P.M.
Podiatric Orthopedics & Biomechanics
Board Certifications:
- American Board of Podiatric Surgery (Foot & Ankle)
- American Board of Podiatric Medicine
- American Board of Disability Analysts (Senior Disability Analyst)
- American Academy of Wound Management (Certified Wound Care Specialist)
- American College of Foot & Ankle Pediatrics
Professional Memberships:
- American College of Foot & Ankle Surgeons
- American College of Foot and Ankle Pediatrics
- American Board of Podiatric Medicine
- American Podiatric Medical Association
- American College of Wound Care Specialists
Hospital Affiliations:
- Hialeah Hospital
- Palmetto General Hospital
- Jackson North Hospital
- Miami Lakes Surgical Center
Medical School:
- California College of Podiatric Medicine, San Francisco, CA (class of 1983)
- Residency: Southeastern Medical Center (1983-1984)
- Fellowship: Southeastern Medical Center (1985-1987)
Academic Appointments:
- Professor of Podiatric Orthopedics & Biomechanics, Barry University
Committee Memberships:
- 2003-2013. Ethics and Credentials Committee.
- 2014. Medical Executive Committee.
- 2001-2005. Pharmacy and Therapeutics Committee.
- 2000-2003. ER Services Committee
- 1991-1995. Faculty Senate.
- 2010. Rank and Promotion Committee.
- 2013. Dean Selection Committee (Health Sciences).
- 1988-1996, 2013-2014. Curriculum Committee.
- 1987–2014. Academic Committee.
- 1987-2010. Executive Advisory Committee.
- 1988-1996. Test Committee Member - National Board of Podiatric Medical Examiners, Princeton.
- 1995-2008, 2012-2020. Florida State Department of Workman's Compensation – Expert Medical Advisor.
- 1988-1996. State Board Podiatric Medical Examination Committee, Florida Podiatric Medical Association: Designated AACPM liaison to coordinate activities between AACPM and FPMA.
- Southerland, C. (2002). Arthroscopic reconstruction of the Unstable ankle. In M Nyska, & G Mann (eds). Chapter 30. The Unstable Ankle. Human Kinetics Publishers.
- Vito. G., Pacheco, M., Southerland, C., Rodriguez, R., Thompson, D. (2005). A new solution for the arthritic ankle: Podiatry Today; 18 (12); 36-43.
- Southerland, C., Feldman, M. (2007). Subtalar Arthroereisis in place of Subtalar Fusion for Subtalar Joint Arthridities: The "Feldman Procedure". Doctors Hospital Update. 1-4.
- Southerland, C., Highlander, P. (2011). Buerger's Disease (Thromboangiitis Obliterans): A Clinical Diagnosis. Skin & Wound Care International. 24 (1): 15-17.
- Southerland, C. (2012) Integumentary lines of influence on the foot. Their importance in incision planning and grafting. Foot and Ankle Quarterly "Anatomic Updates of the Foot and Ankle". 22 (1): 1-11.
- Wilson, T.C., Snyder, R.J., Southerland C. (2012) Bullosis Diabeticorum: Is there a correlation between hyperglycemia and this symptomatology? Wounds. 24(12):350–355.
Scientific and Research Presentations:
- Southerland, CC. (2005, 2006, 2007). 7 Theorems of Compensation in the Human Lower Extremity, Gait Analysis using Homunculus for recording Observations, Use of Orthotic Devices for Pes Anserine Bursitis, Methods of determining NCSP for Clinical Measurement. PFOLA (Prescription Foot Orthotics Laboratory Association) Annual Conference(s); Fremont CA, Vancouver Canada, Miami FL,
- Southerland, CC. (2010).7 Theorems of Compensation in the Lower Limb, Biomechanics of Medial Knee Pain, The Role of Gait Analysis in Orthotic Prescription Determinations, Understanding the significance of NCSP and its role in Functional Orthoses, Orthotic Prescriptions for Clinical Pathomechanics; Canadian Biomechanics Summer Seminar August 13-14, 2010- Nottawasaga Inn Resort, Toronto, Canada
- Southerland, CC. (2013) Wound Classification and Use of Grafts & NPWT in Diabetic Limb Salvage. National Podiatric Medical Association Annual Educational and Scientific conference: June 26-30 2013. At the Conrad Hotel, Miami, Florida.


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Viewing posts tagged giant trees
Sequoia National Park, California
Posted by: budgettravel in California, Hikes, Interesting Natural Feature, United States of America 2 years, 4 months ago
Sequoia National Park
Venturing into Sequioa National Park is venturing into a land of ancient giants. As we drove up Generals Highway from the south, we encountered many a giant around every corner, some as part of a family of giants, others as lone giants. We couldn't wait to park and start our hike once we reached the Giant Forest Museum. Luckily, there were many trails for us to stand in awe of these trees as old as 3200 years old. Of course, despite its name, Sequioa National Park is not just about giant sequoias. We managed a trail or two into different environments as well, walking through snow to reach a mirroring subalpine lake, and walking through dry foothills to a cascading waterfalls over marble rock.


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Create database tables and fields in Web & Classic Hosting
You can create tables and fields only after you set up a SQL Server database. For information, see Setting up a SQL Server Database on Your Hosting Account.
- Log in to your GoDaddy account.
- Click Web Hosting.
- Next to the hosting account you want to use, click Manage.
- In the Databases section of the Hosting Control Panel, click the SQL Server icon.
- Next to the appropriate database, click Admin Tool.
- Enter the User Name and Password you used when setting up the database.
- Under the appropriate database, click Tables.
- In the Tables header, click the yellow star icon.
- Enter the table name and the number of fields, and then click Next Step.
- For each database field, enter its properties.
- Click Create.


text: At its December meeting, the Atlantic General Hospital Auxiliary donated $65,000 to the hospital's foundation, with $30,000 supporting the annual campaign. The remaining $35,000 is a pledge to the Major Gifts campaign. Pictured, from left, are Outgoing Auxiliary President Emma Fralley; Michael Franklin, president and CEO of Atlantic General Hospital; Janice Slaysman, Auxiliary treasurer; Outgoing Auxiliary Vice President Joanie Stearn; and Auxiliary Corresponding Secretary Kay Heinlen.


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about the projectpeopleWalter Bender
back to list
Submitted by giulia on Thu, 2011-09-22 10:45
Walter Bender
Founder and executive director of Sugar Labs
Walter Bender is founder and executive director of Sugar Labs, a non-profit foundation. In 2006, Bender co-founded the One Laptop per Child, a non-profit association with Nicholas Negroponte and Seymour Papert. As director of the MIT Media Laboratory, Bender led a team of researchers in fields as varied as tangible media to affective computing to lifelong kindergarten. In 1992, Bender founded the MIT News in the Future consortium, which launched the era of digital news.


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國禎環保將秉承"致力民族水務 改善生態環境"的理念,為社會為人民創造清潔、良好、和諧的生活和工作環境,使公司成為國際一流的水環境綜合利用服務商。
Company Profile
Anhui Guozhen Group Co., Ltd. is a joint-stock enterprise group incorporated in1994 with permission of the Anhui provincial government. The company has always been adhering to the enterprise tenet of "Serving the country and the society with industrial achievements" initiated by Mr. Li Wei, the founder of the company, promoting the enterprise spirit of "Being honest, thrifty, competitive and creative", bearing in mind the development policy of "What the society needs is where we are heading for" and committing ourselves to the development of five industrial sectors which have close relationships with the society and people's livelihood: water, clean energy, eco-utilization, environmental remediation and health management.
The Group has made continuous progress during the past twenty two years and now has more than ten wholly-owned or controlling subsidiaries, such as Guozhen Environmental Protection, Guozhen Gas, Guozhen Eco-technology, Guozhen Real Estate, Guozhen Health, Guozhen Environment Remediation, etc. In 2015, the group witnessed an operating revenue of 5 billion yuan, with a total asset of 9.3 billion yuan and around 3500 outstanding management and technical personnel, all demonstrating a sustainable development. The company has been on the list of top 500 enterprises of service industry in China for three consecutive years and the list of top 100 enterprises in Anhui Province for four consecutive years.
Main Sectors of the Group Company
1. Guozhen Environmental Protection
Founded in February 1997 with a registered capital of 300 million yuan, Anhui Guozhen Environmental Protection Technology Joint Stock Co., Ltd.(GZEP), now with 2130 employees, is one of the specialized companies in China that first offered integrated solutions in the marketization process of domestic waste water treatment industry, featuring "one-stop six-dimension services". Since its listing in ShenZhen Stock Exchange in 2014(300388), the company has always been committed to the integrated utilization of water resources, and has now formed a full life cycle industry chain ranging from design and R&D, project contracting, equipment R&D and integration, operation management as well as investment and financing of municipal and industrial waste water treatment, upgrading and reconstruction of near IV water, as well as small town sewage and minor drainage basin treatment.
At present, the company has over 100 waste water treatment plants all over China, with a treatment capacity of over 4 million tons per day. Its typical projects include Hefei Qingxi Water Treatment Plant, Hefei Chaohu River DBO, the Reclaimed Water Pilot Project of Changsha Xianghu Lake Waste Water Treatment Plant and Qingdao Li County River Waste Water Treatment Project, etc.
As one of the first batch of innovation-oriented companies, the company has hosted and participated in four research subjects of China's 863 Program (National High-tech Research and Development Program) and two research subjects of China's National Key Technology R&D Program, and has won twice the Second National Prize for Progress in Science and Technology. Besides, It has also hosted and participated in compiling thirteen national and industrial standards, and owns 47 patented technology, among which 21 are patents for invention.
GZEP will be adhering to the principle of "Improving the ecological environment by devoting ourselves to the national water industry", and create for the society and people a clean, good and harmonious living and working condition, while in the meantime become a highly-ranked international service provider of comprehensive utilization of water environment.
2. Guozhen Gas and Guozhen LNG
Fuyang Guozhen Gas Company was founded in June 1997 with a registered capital of 92.91 million yuan. With a staff of 592 people, it is now the only one company in Fuyang City that is qualified for both urban pipeline gas operation and pipeline engineering installation. The company exclusively undertook the national "West-East Natural Gas Transmission" Project in Fuyang City, including its counties and cities, and has established a complete urban natural gas transmission & distribution and supply system consisting of one natural gas station, one master station, four stations for storage and distribution, twelve vehicle fueling stations as well as 1,300 km of pipelines. With annual sales of 120 million cubic meters, the company has carried oil and gas from Tarim Basin of Xinjiang Province to enterprises, institutions and numerous families in Fuyang City and its five surrounding counties and cities. In the meantime, the company has cooperated with Shandong Dongming and Shanghai Jianglu and established an integrated operating system, featuring production, wholesale and retail of refined oil products with annual sales of 35 million liters. The company has, for many times, won titles such as Anhui Excellent Private Enterprise, Fuyang Top 100 Enterprises, Fuyang Top 10 Non-public Tax Payers, etc. At present, the company is making efforts to set up a diversified cross-region clean energy group company by asset restructuring and corporate mergers and acquisitions. Moreover, it has carried out strategic cooperation with famous Chinese security companies in fully launching its IPO, aiming at an extraordinary development.
Anhui Guozhen LNG Company, separated from Fuyang Guozhen Gas Company, was founded in August, 2015 with a registered capital of 5 million yuan and a staff of 189 people. The company owns a special railway line of 1000 meters, more than ten tank cars as well as an LNG storing capacity of 6500 cubic meters. Operating 15 LNG stations, it is now the largest enterprise in Anhui Province in terms of assets and market in LNG business. In addition to Fuyang market, it has also set up branch offices in Dongming, Jinan, Nanjing and other cities, and has been actively involved in markets of Lu'an, Huainan, Bozhou and other surrounding cities, holding some important positions in Henan, Shandong and Jiangsu provinces. Presently, the company is making great efforts to expand and integrate its market through projects operation, as well as strengthen and standardize the market through site construction, distribution service, channel control and other terminal management so as to make itself bigger and stronger.
3. Guozhen Eco-tech
Anhui Guozhen Eco-tech Co., Ltd. was founded in February 2016 with a registered capital of 100 million yuan and it now has a staff of 247 people. The company has been committed to comprehensive utilization of biomass such as straw and other agricultural and forestry residues and production of three main products, i.e. heat, power and soil remediation agent(ecological fertilizer) which take biomass as raw material. Benefiting from cooperation with other enterprises both at home and abroad, Guozhen Eco-tech has grown to be an integrated company of investment and operation, equipment manufacturing and project engineering, featuring cyclic use of agricultural and forestry waste, for example, it cooperates with Hangzhou Boiler Group and introduces advanced technologies from PNPP Company of Germany so as to develop and own the ultra-high-temperature-and-pressure thermal power generation technology, works with Hefei Cement Research Institute to develop and own the integrated technology of desulfurization, de-nitrification and dust removing, and also joint hands with Institute of Soil Science of Chinese Academy of Sciences in Nanjing to develop and own eco-fertilizer technology. At present, it has three subsidiary companies, i.e. Guozhen Meijie (Anhui) Biomass Thermal Power Co., Ltd., Bozhou Guozhen B, iomass Thermal Power Co., Ltd. and Anhui Guozhen Mingguang Biomass Power Generation Co., Ltd.
In t, he future, the compan, y will continue to integrate biomass-related resources and business within Guozhen system and further develop solid waste disposal business so as to establish its core competence in eco sector and achieve the IPO of its main business, i.e. biomass power generation.
4. Guozhen Environment Remediation
Founded in April, 2016 with a registered capital of 60 million yuan, Anhui Guozhen Environment Remediation Co., Ltd. is a high-tech enterprise specialized in soil and underground water remediation. Ever since its inception, the company has been striving to set up a full industrial chain in environment remediation and enhance its general capacity through mode innovation, technological R&D, engineering practice as well as team building. Based on relations with Guozhen Group and GZEP, the company has established strategic cooperation with several famous scientific institutes and enterprises such as Chinese Research Academy of Environmental Sciences, Institute of Soil Science of Chinese Academy of Sciences in Nanjing, Anhui Research Academy of Environmental Sciences and MWH Environmental Engineering (Shanghai) Co., Ltd., etc. With ever-rising technical strength and brand influence, the company will gradually be able to offer one-stop environment remediation service which includes contaminated site investigation, risk evaluation, repairing proposal design, remediation project construction and also follow-up monitoring and assessment, and eventually become a famous integrated service provider of soil and underground water remediation.
5. Guozhen Health and Guozhen Real Estate
Anhui Guozhen Health Industry Investment Co., Ltd. was founded in 2010 with a registered capital of 20 million yuan and mainly focuses on investment, construction and management of health industry and its related service industry. Responding to the emerging requirements of the society, the company has put forward its own health concept, i.e. "mind purification, health guide, green food, health maintenance and back to nature". While taking "disease prevention, fighting against aging and nurturing the body and soul" as its goal, the strategic transition of Guozhen Real Estate and Guozhen Health Building as its basis, the company has combined Chinese traditional medical essence and modern medical tests and equilibrium intervention treatment technology, aiming at creating a system which integrates physical examination, health assessment and intervention, plus a platform which provides high-end physical tests, equilibrium intervention, TCM physical therapy, athletic rehabilitation, nutritious diet, high-end apartment and private health maintenance theme club and providing one-stop health maintenance service for medium-and-high-end customers. Within the next three to five years, the company will strive to get listed and step into the international world as a famous group company.
Guozhen Real Estate Company Co., Ltd. was set up in 1993 with a registered capital of 106 million yuan. Qualified as a second-grade real estate developer in China, it has always been committed to its , concept of "low-carbon life, green house and healthy community" and has put this concept into practice throughout the process of planning development, operation and service. Taking Anhui province as its basis, the company mainly expands its market in the northern part and has witnessed success of many projects, including various kinds of high-end residential buildings and urban complex in Hefei, Fuyang, Bengbu, Jieshou, and Mengcheng city of Anhui, , Haikou, Danzhou city of Hainan, as well as Changsha, Hunan Province, with a total, floorage of 2 million square meters, winning good social and economic benefits. Within the next five years, the company will cooperate with Guozhen Health and develop health and senior living projects so as to turn a new chapter in Guozhen health industry.
Diversified Industries of Guozhen
Some other subsidiary companies of Guozhen Group such as Zhenzhixin International Trade Company, Guozhen Culture and Media Company, and Dongfangxu Electrical Equipment Company have also made progress and become an important support to the group company.
1. Anhui Zhenzhixin International Trade Company, founded in 2013 with a registered capital of 30 million yuan, has its HQ in Hefei and a wholly-owned entity in Ningbo, i.e. Ningbo Dibang International Trade Company, which is a professional trade company dealing imports, transshipment trade, exports as well as domestic trade of staple commodities such as rubber, chemical products, plastics, non-ferrous metals, mineral products, etc. With 400 million yuan of assets, the company boasts a professional staff, featuring good business capabilities and excellent relations with upstream and downstream enterprises and more than ten customer companies. Sticking to its operation concept of "trade business serving for financing and entities", the company will work hard to expand its market abroad and lay a solid foundation for the internalization of Guozhen Group.
2. Anhui Guozhen Culture and Media Company, founded in 2013, mainly focuses on branding, brand image design, advertising idea design and production, product packaging, terminal stores design, activity planning and execution of sales promotion, PR and exhibitions, and integrated marketing of new media, website planning, design and development.
3. Anhui Dongfangxu Electrical Equipment Company, founded in 2001 with a registered capital of 30 million yuan, is a high-tech company which manufactures various kinds of electrical equipment such as medium-and-high-voltage vacuum circuit breakers, vacuum load switches, complete switchgears, and transmission and distribution lines, and also provides equipment engineering installation. As a long-term partner with Anhui Grid Company and the State Grid Company, it has kept a good relation with many universities and colleges in Hefei and developed many pioneering new products such as intelligent vacuum circuit breakers, intelligent switch cabinets for the internet of things, which can be remotely controlled. At present, the company has acquired six software copyright, two patents for utility models and one patent for invention.
Guozhen Culture and Charity Undertakings
1. Guozhen Culture
Holding high the great banner of socialism with Chinese characteristics, the company has had in-depth study of Secretary-General Xi Jinping's series of important speeches, and conscientiously implemented the guiding principles of the Eighteenth National Congress of the Party, the third, fourth, fifth and sixth Plenary Sessions of the 18th Central Committee of CPC. Under the leadership of the Communist Party of China, the company has set up the Party Committee, Trade Union, as well as Commission for Discipline Inspection. With establishing service-oriented grass-roots Party, Labor and Group Organizations as its goal, the company has launched education activities concerning studies on the theoretical and practical issues of party buildings and has given full play to the vanguard and exemplary role of Party Organizations. In the meantime, the company has also actively promoted probity and self-discipline and implemented the Eight Rules of Political Bureau of the Central Committee, which shows its firm stand in building a clean administration. Based on Guozhen News, Guozhen Magazine, and its internal and external websites, social media as well as the new media such as Wechat and Weibo, the company has done good propaganda work. Besides, various recreational and sports activities have also been arranged, for example, get-together parties, speech contests, post skills contests, basketball games, etc. Guozhen Group was among one of the second batch of model private enterprises which have done a good job in taking precautions against duty crime in 2016 and has also, for many times, been awarded honorary titles for its excellent work in enterprise as well as party building by the Party Committee of Hefei.
2. Guozhen Charity Undertakings
Adhering to its principle of "Serving the country and the society with industrial achievements", the Group Company set up Guozhen Academy in 2009 to give more back to society. During the past seven years, Guozhen Academy has hold around one hundred training classes concerning Chinese Classics, and more than 160 weekend classes. Besides, it has also taken on many government purchasing projects and benefited tens of thousands of people. In 2011, Guozhen Charity foundation was established. It has made donations for education, helped the poor and also launched many charity activities which offered help to more people. This is what Guozhen Group has done for the society, which has also turned a brand new chapter in its charity undertakings.
The road ahead is much challenged but also full of chances. We need to forget the achievements we have made and continue to work hard for the future. The Guozhen Group will continue to focus on environmental protection such as waste water treatment, and integrated use of solid waste, the development and study of new energy and clean energy, as well as the one-stop health management, so as to improve both the eco system, physical and psychological health, and complete the strategic transformation from a products-oriented to service-oriented company. We will strive to achieve an annual output value of 20 billion yuan by the end of 2020 and enter the top 500 of Chinese private enterprises.


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An important Brandeis study appearing in the December 3 issue of Nature raises the curtain on the hidden lives of proteins at the atomic level. The study reports that for the first time, researchers used x-ray crystallography and nuclear magnetic resonance (NMR) techniques to directly visualize protein structures essential for catalysis at the rare high-energy state. The study also showed how the motions of these rare, or hidden, structures collectively, directly contribute to enzyme catalysis.
In doing so, the study also suggests new molecular sites for potential drug targets, the cornerstone of rational drug design. Drugs may bind, or dock, to the infrequent high-energy states of target enzymes that have been hidden to traditional structural methods. The thinking is that drugs can be designed by docking algorithms to a collection of protein structures, not just one, providing better bio-molecular targeting.
This study comes in the wake of earlier Brandeis studies aimed at advancing understanding of protein function using pioneering techniques such as NMR. For a long time, scientists viewed proteins more or less as macromolecular wallflowers, venturing out onto the atomic-level dance floor to perform only during catalysis, their active state.
Then, several years ago, Brandeis biophysicist Dorothee Kern reported in Nature that her lab's experiments using NMR also linked protein function to their much rarer high-energy state, in the absence of catalysis. That study helped put to rest the conventional wisdom that proteins actually rest at all.
This Nature study takes Kern's research to the next level, seeing the high-resolution structure of the hidden, high-energy state for the first time. For this success, high–resolution x-ray crystallography was further pushed by analyzing electron density data previously discarded as "noise" and by collecting data at ambient temperature. The protein of interest is human cyclophilin A, an enzyme that is highjacked by the HIV virus to aid its own replication.
But it was thanks to some clever protein design together with dynamic NMR spectroscopy that provided direct experimental evidence that the hidden structures in the high-energy state are in fact essential for catalysis. The researchers revealed what happens when proteins flip from the rare state to a major state in a process called interconversion. If this flip is fast, then the enzyme does its job fast, but if the flip is slow, as in the designer enzyme, then the enzyme operates slowly.
"People always focused on the chemistry—accelerating the reaction through catalyzing the chemical step of the substrates. What we've shown is that protein dynamics is as important as the chemical step," said Kern, a Howard Hughes Medical Institute Investigator. "Basically, all the steps need to be choreographed just right, like steps for a beautiful dancer. An enzyme can only function well with the perfect choreography of all the components."
Said Kern: "We now can show directly that the higher energy states are always there and that these hidden, rare states are absolutely essential for protein function."


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Facebook will give app developers $30,000-worth of free services and support to anyone who wants to build an app.
The initiative was announced at Facebook's F8 conference for developers. You can qualify for the offer by having an app live for 30 days before applying for the program.
Facebook is making a huge push to take over the mobile app business from the ground up. Facebook owns a company called Parse, which provides back-end services for app developers. Any company can use some or all of Parse's services and tools, which are stored in the cloud — so companies don't need to run their own servers to maintain their apps. They can just let Facebook and Parse do it.
A majority of Facebook's users now access the social network on mobile devices. CEO Mark Zuckerberg told F8 today that he basically sees mobile apps as the future of Facebook's business. (That's also why he's splitting off pieces of Facebook into separate apps, like Messenger for messages; and why he acquired Instagram and WhatsApp.)
In fact, Facebook has driven 350 million mobile app "installs" (or downloads) thus far.
The cost of creating an app has been falling for years. Back in the day, it would take millions of dollars in development costs and programmer salaries to create huge new apps. But today, a couple of college kids living in their parents' house can make the most popular apps on the planet in just a few weeks for a few thousand dollars. That's exactly what happened at Snapchat — CEO Evan Spiegel and his team created the messaging app at his father's house on a summer break from college.
So $30,000 of free app creation and distribution services could — in theory — seed a wave of new app development, all using Facebook's platforms. The program positions Facebook as app developers' greatest friend. They have to qualify, of course, but the program is open to all developers regardless of which platform they're creating on (i.e., Apple's iOS or Google's Android).
The $30,000 "FbStart" offer includes the following:
- Access to Facebook Start to Success Program.
- Parse credit.
- Adobe Creative Cloud.
- Appurify testing suite.
- Desk.com customer care tool.
- Proto.io prototyping tool.
- UserTesting UX research tool.
- Workable recruitment tool.