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Stem cell therapy continues to show promise as an effective treatment for more advanced multiple sclerosis, albeit not without risk. Results from studies that have been ongoing for many years are slowly being published, including data from a Canadian study of immunoablation (wiping out the immune system with chemotherapy) and autologous haemopoietic stem-cell transplantation (transplantation of a patient's own bone marrow-derived stem cells), also known as IA-HSCT, for aggressive multiple sclerosis.
The Canadian study — a small phase II trial led by Drs. Mark Freedman and Harold Atkins — enrolled 24 patients with aggressive MS who underwent the chemotherapy/stem cell therapy procedure. Results demonstrated that IA-HSCT was effective in halting disease progression (no relapses and no new gadolinium-enhancing or T2 lesions) in about 67 percent of participants in the three years post-treatment. Sixteen patients experienced no increase in disability, seven patients experienced continued increase in disability, and one patient died from treatment-related complications. To date, surviving participants have been followed for four to 13 years, and 35 percent have experienced reduced disability.
Earlier reports of this type of stem cell therapy in MS were discussed in the journal Neurology (Freedman and Atkins, 2004), followed by a more recent "Top 10 Lessons Learned" article appearing in Neurotherapeutics (Atkins and Freedman, 2012). The MS patient profiled in the current stories circulating the internet, Jennifer Molson, initially shared her story in 2010. It's great to see that she continues to do so well 14 years after treatment.
Similar studies have taken place in the United States. Last year, three-year interim results of the HALT-MS (High-Dose Immunosuppressive Therapy and Autologous Hematopoietic Cell Transplantation for Relapsing-Remitting Multiple Sclerosis, or HDIT/HCT) trial sponsored by the National Institutes of Health were published in JAMA Neurology (Nash et al., 2015). Among 24 individuals with RRMS who underwent HDIT/HCT treatment, 90.9 percent were progression-free and 86.3 percent were relapse-free at three years' post-procedure. These interim results are impressive; however, there are anecdotal reports from select participants in the HALT-MS trial who have reported disease activity returning after the three-year mark.
Patients in the U.S. have traveled to Russia and Chicago to undergo the same/similar stem cell therapy for years. I have a blogging friend who went to Russia for treatment and hasn't experienced any signs of MS since. Another vocal proponent of the therapy who went to Chicago to be treated by Dr. Richard Burt at Northwestern University has shared her story throughout social media. I only mention this to point out that the "cure" reported in the news last week is not new at all. However, each trial helps researchers to better identify the types of MS patients**, those with active inflammation,** who would most benefit from this procedure which carries significant risks.
Dr. Burt is currently recruiting people with relapsing MS who have inflammatory disease activity despite disease-modifying therapy to participate in a study which will compare autologous haemopoietic stem-cell transplantation (aHSCT) with standard therapy for MS (such as interferon beta 1-a, interferon beta 1-b, glatiramer acetate, mitoxantrone, natalizumab, fingolimod, or dimethyl fumarate). Details are included at Clinicaltrials.gov and you can find additional information about Dr. Burt and the history of HSCT research at Northwestern University on Northwestern's website.
Finally, if you are interested in connecting with other MS patients who have undergone or are considering HSCT therapy, check out the Hematopioetic Stem Cell Transplant Facebook group.
See more helpful articles:
Atkins HL, Bowman M, et al. Immunoablation and autologous haemopoietic stem-cell transplantation for aggressive multiple sclerosis: a multicentre single-group phase 2 trial. The Lancet. Published online: June 9, 2016. DOI:
Atkins HL, Freedman MS. Hematopoietic Stem Cell Therapy for Multiple Sclerosis: Top 10 Lessons Learned. Neurotherapeutics. 2013;10(1):68-76. doi:10.1007/s13311-012-0162-5.
"This isn't hype: Canadian doctors just reversed severe MS using stem cells," by Julia Belluz and Javier Zarracina on June 9, 2016. Vox.com. Accessed at http://www.vox.com/2016/6/9/11898512/multiple-sclerosis-stem-cell-chemo
"'I got a second chance at life': An aggressive Canadian treatment offers stunning results for MS patients," by Jennifer Yang on June 9, 2016. Thestar.com. Accessed at https://www.thestar.com/news/world/2016/06/09/i-got-a-second-chance-at-life-an-aggressive-canadian-treatment-offers-stunning-results-for-ms-patients.html


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George NitescuVerified 1 Review
About George
Hi! I'm here to help you reach your health and fitness goals amidst all the craziness of life in LA. I spend a lot of hours in an office, so I know the struggles that poses to a healthy lifestyle, and I can help you around them.
I'm a trainer because I've known too many people who want to become more healthy and fit but don't know how to overcome roadblocks: gyms are intimidating, lack of motivation, not enough knowledge of diet and exercise, working out sucks. There's nothing more satisfying to me than giving someone the tools to overcome these things and seeing how happy it can make them. I promise I can help you find ways to work out that you'll have more fun with than you ever thought you could.
If you've got a busy schedule and are trying to figure out how to incorporate fitness and healthier nutrition into your lifestyle, believe me: I understand, it's totally possible, and I will help you figure it out. As a previous powerlifting competitor, martial artist, and overall athletic enthusiast, I'll create personalized plans for you to achieve all your fitness goals, whether you're in it for intense athletic training or, shedding some weight, or recovering from a serious injury!
Areas of Expertise
- Core and Balance
- Nutrition
- Strength Training
- Weight Loss
- Muscle Gain
- Cardiovascular Conditioning
- Corrective Exercise
NCCA Accredited Certifications
Biomedical Engineering
Who I Especially Like Working With
Actors, Bodybuilders, Men, Post-rehab, Rehab, Seniors, Women, Youth
Medical Conditions Experience
Back Pain/Issues, Bone/Joint Injury, Depression, Hip Pain/Issues, Knee Pain/Issues, Lower Body Pain/Issues, Obesity, Postural Issues
Additional Languages Spoken
Romanian, Spanish
Training Areas Served
In-home or Outdoor Personal Training
I have had personal training at Gold's Gym and LA Fitness, but I was never satisfied. I always felt the trainer was rushing because their next client was waiting. I met George in the gym and later found out he is a personal trainer. He trained me so much better than the other trainers had. We have become friends, and he's always my go to guy when I have fitness related questions. You get out what you put in. If you give George your 100% performance, I know you will get that in return from George. And, his motivational speech and delicious diet plan are included. Give him a try, you will definitely get your moneys worth! ???

subset: commoncrawl


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13+ befristetes arbeitsverhältnis
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About Us
Duke Cafe is a Breakfast takeaway in Edinburgh. Why don't you try our or ?
47-49 Duke Street, Edinburgh, EH6 8HH
Duke Cafe is a Breakfast takeaway in Edinburgh. Why don't you try our or ?
8 reviews from Just Eat
The delivery boy was so polite and lovely, what a great service...food delish as always. My go to hangover grub, is cheese and tomato toastie, greek salad and a decent coffee. Thanks guys.
I was happy with the quality of food and happy that delivery is available for lunch time and it's fast and the driver was very polite, will order from here again.
Just ordered from here for the first time and it was great, will definitely be returning! ☺ the food was really cheap, very tasty, delivery was really quick, and delivery guy was friendly. Keep up the good work!
Arrived on time, was still really hot. Donner wrap was absolutely delicious and also mozzarella sticks. Definitely will be ordering again.
Food was good and came early, the delivery driver was very nice and polite and the portions were great. Definitely helped my hang over :)
Food arrived quickly, nice and hot too. Very tasty and the delivery driver was nice. Will definitely order from here again :)
As always, the duke cafe delivered early and the food was delicious. They never fail to impress and I will definitely order from here again. Thanks.
Great good amazing service, and great delivery time food was great & would highly recommend been there a couple times and would go back again
Duke Cafe
47-49 Duke Street
Please note, delivery times may vary.


text: 0 0 By Drawing Near to God In Encouragement, Guest Blog, Joanne's Blog, Parenting, WomenPosted January 29, 2015Guest Post – A Tall Glass of GraceToday, we have a guest post from Teresa Glenn, a wife and mom of three. Please check out Teresa's blog about walking with Christ as a mom, called Celebrate the Family, here. A Tall Glass of [...] READ MORE


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Wednesday, 27 October 2010
So much news my head may fall off!
I have so much exciting news this week I hardly know where to begin… So let's start with this!
Dark Fiction Magazine (www.darkfictionmagazine.co.uk) is pleased to announce the launch of a new service for fans of genre fiction. Beginning Oct 31st (Halloween), Dark Fiction Magazine will be launching a monthly magazine of audio short stories. This is a free service designed to promote genre short fiction to an audience of podcast and radio listeners. A cross between an audio book, an anthology and a podcast, Dark Fiction Magazine is designed to take the enjoyment of short genre fiction in a new and exciting direction.
Dark Fiction Magazine publishes at least four short stories a month: a mix of award-winning shorts and brand new stories from both established genre authors and emerging writers. Each episode will have a monthly theme and feature complementary tales from the three main genres – science fiction, fantasy and horror.
Co-founder Del Lakin-Smith said: "I love reading short stories, and with the increased uptake of mobile and portable devices this really is a growth area. But like many I find I don't have as much time as I would like to read, so I tend to listen to many podcasts on the go. The idea of replacing my podcasts with high quality, well performed audio short stories is something I find highly appealing, so Sharon and I set about making that a reality."
Sharon Ring, co-founder of Dark Fiction Magazine, said: "From technophobe to technophile in less than two years; I spend a great deal of time working online. To while away those hours, I like to listen to podcasts and drink copious amounts of strong coffee. Now, while I don't recommend you drink as much coffee as I, I do recommend you check out what Del and I have created. We love podcasts; we love genre fiction; we built a site to bring the two together."
The theme of Dark Fiction Magazine's first episode is The Darkness Descends and will feature four fantastical stories:
'Maybe Then I'll Fade Away' by Joseph D'Lacey (exclusive to Dark Fiction Magazine)
'Pumpkin Night' by Gary McMahon
'Do You See?' by Sarah Pinborough (awarded the 2009 British Fantasy Society Short Story Award)
'Perhaps The Last' by Conrad Williams
Lined up for future episodes are Pat Cadigan, Cory Doctorow, Jon Courtenay Grimwood, Ramsey Campbell, Rob Shearman, Kim Lakin-Smith, Ian Whates, Lauren Beukes, Mark Morris, Adam Nevill, Gareth L Powell, Jeremy C Shipp, Adam Christopher, and Jennifer Williams, among others.
With a team of dedicated and passionate narrators, a central recording facility and a love of genre, Dark Fiction Magazine delivers a truly outstanding aural experience.
Dark Fiction Magazine will also be producing special editions with seasonal stories and topical issues, competitions, flash fiction episodes and novel excerpts. Each episode aims to shock and delight, to horrify and confound as Dark Fiction Magazine takes its listeners on an aural tour through the world of genre fiction.
Dark Fiction Magazine is a collaborative project, created and developed by Del Lakin-Smith and Sharon Ring. For further information, contact Del or Sharon at
You might have noticed my name on the end of a pretty impressive list there, so unsurprisingly I am quite chuffed. But not only have I got a story coming up in later episodes, I am also doing some "reading out loud" duties- Nerve-wracking indeed, but I can tell you now that the story I got to do my Jackanory voice on was aces. As soon as it actually launches I will be straight on here to do a little snoopy dance for you all.
In other news, the lovely people over at the Un:Bound blog have let me taint their marvelous pages with a new short story at part of their Writer Wednesdays. This odd little thing has long remained one of my favourites, even though I sense it may be an acquired taste- I'd love to know what you think!
Posted by senny dreadful at 15:28
Labels: audio fiction, Barleycorn, Dark Fiction Magazine, epic win, Jackanory, podcasts, Short Stories, Un:Bound blog, writing
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(photo courtesy of Beth Sullivan)
Both sides of Avery Hill Road, 0.75 miles north of Route 214. Parking lot on East tract. Approximately 1 mile of hiking trails.
- West Tract, 76.59 acres (1970). Open upland woods, Billings-Avery Brook and glacial boulder deposits.
- East Tract, 22.48 acres (1977). Maple swamp and upland woodlands, giant rhododendron, atlantic white cedar, orchid species.
- Sheep Wash Tract, 0.49 acres (1995). Historic dry-wall sheep wash, south of Billings-Avery Brook.
- Town of Ledyard Transfer, 0.53 acres (2014). Addition to the west tract.
Read More About Avery Preserve


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The Story:The Last 5 Years is a musical love story for a new generation. The story explores a five year relationship between Jamie Wellerstein, a rising novelist, and Cathy Hyatt, a struggling actress. The show uses a form of storytelling in which Cathy's sotry is told in reverse chronological order (beginning the show at the end of the marriage,) and Jamie's is told in chronological order (starting just after the couple have first met.) Their characters do not directly interact except for a wedding song in the middle as their timelines intesect.
Melanie is overjoyed to be once again joining Wine Country Theatre with this beautiful show, The Last 5 Years. Melanie is a Paso native and graduate of the UCLA school of Theatre, Film, and Television. She has performed at the Geffen, the Celebration, and Rouge theatres in L.A. She appeared in SlO Little Theatre's Singing in the Rain as Lina Lamont, A Chorus Line as Kristine, and in WCT's Last of the Red Hot Lovers as Bobby Michelle-- all talented actresses with excruciatingly awful singing voices. Melanie would like to express her love and gratitude to her mum, her director, Gregg, music director John and her co-star Cody Pettit for their support, talent, and passion and to dedicate her performance to the person who taught her to tell stories and find humor in pain, her dad Mark Portney (1964-2015).
Cody Pettit is a Cambria local who has been performing in and around SLO county for over ten years. He has always wanted to be a part of a production of The Last Five Years and he is very grateful for the opportunity to help tell the story. Favorite past roles include Frankie in Forever Plaid, Mortimer in Arsenic and Old Lace, Princeton in Avenue Q, Leaf Coneybear in The 25th Annual Putnam County Spelling Bee, Bobby Strong in Urinetown, the title role in Tarzan, and Al in A Chorus Line (Where he first worked with costar Melanie Portney and director Gregg Wolff) among others. This is his second show with Wine Country Theatre, the first being I Love You, You're Perfect, Now Change! in 2014. Cody wants to thank everyone who has made this show happen, in particular Gregg for his passion and motivation and John for his dedication to the marriage of music and story. Enjoy the show!
San Luis Obispo Little Theatre: Wit (Harvey Kelekain), When The Rain Stops Falling (Gabriel York), The Arsonists (Director), Time Stands Still (Richard), A Chorus Line (Zach), Good People (Mike), A Christmas Story (Ralph), Psychopathia Sexualis (Howard.) Locally seen in Kelrik's': Cats, Adams Family Reunion, and Love Town. Other shows/roles: Tuesdays With Morrie (Mitch), Dinner With Friends (Tom), Gun Shy (Carter), Rumors (Glenn), The Full Monty (Keno), Miss Saigon, Side Show, Night Watch and As Is. Before becoming an internal medicine physician, Gregg was a struggling actor in NYC, waited tables, delivered singing telegrams, and worked as an "elf" at Macy's Herald Square "Santaland".


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Opinions, Schools
Weighing-in on Annapolis' school yard fight
Bill to give Maryland's local school boards scheduling autonomy passes..
Opinions, Economy & Business
Hello, welcome and…goodbye?
Walmart incurs wrath of public for redefining greeter's job. Is that right?.
Opinions, Health & Wellness
Opponents speak out against advancement of assisted suicide bill
Assisted suicide bill advances towards final vote in the House of Delegates..
Opinions, Government Spotlight
Fisher says several pending bills encourage voter fraud
Bills promoting voter fraud have passed out of committee..
Government & Politics, Opinions
Town officials oppose bridge option
Mayor and town council say "no thanks" to possible bridge location..
Government & Politics, Opinions
General Assembly session is a dangerous time
A lot can happen when the Maryland legislators are in session..
Opinions, Government Spotlight
Calvert board weighs in on bay crossing controversy
Commissioners reaffirm opposition to bridge crossing point being located in Calvert..
Opinions, Weather
Remembering the deep freeze
Southern Maryland's notorious ice storm occurred 25 years ago this month..
Government & Politics, Opinions
Hoyer releases statement on State of the Union Address
Congressman Steny H. Hoyer (MD-05) released the following statement on President Trump's State of the Union Address:.
Government & Politics, Opinions
Cardin, Van Hollen respond to State of the Union Address
Cardin offered the following remarks after President Trump's State of the Union Address..
Opinions, Health & Wellness
Views differ dramatically on 'end of life option'
The controversial end of life option is again before the Maryland Legislature..
Government & Politics, Opinions
Here is the crisis Democrats say doesn't exist
President Trump opines about border security..
Government & Politics, Opinions
Cardin hails end of government shutdown
Maryland's senior senator says chamber worked in a bi-partisan manner..
Opinions, Weather
A season to be endured
Winter doesn't appear to be good for much---or does it?.
Opinions, Schools, Economy & Business
Bailey lauds governor's inclusion of Higher Ed Center funding
Bailey's statement on funding for the University System of Maryland Academic and Research Center..
Government & Politics, Opinions
Hoyer's statement on the opening day of the 116th Congress
Hoyer is now House Majority leader..
Government & Politics, Opinions
Crosby pledges to 'deliver the best for St. Mary's County'
Crosby will represent District 29B in Annapolis..
Opinions, Holiday
Spreading the spirit
Eradicating darkness isn't easy and neither is Christmas..


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La Marca
La Marca came into being in 1968 from the intuition of a noteworthy group of winegrowers who felt the need to introduce the quality of their local wines to the world. They came together to pool their energies and experience to protect and represent their wines.
It was of the utmost importance to create a technical and commercial organization able to support the winegrowers in growing grapes and serve as a commercial platform to promote awareness of the area's quality wines. The company continued to grow year after year working with high levels of professionalism on the quality, the image and typical characteristics of the territory.
La Marca is today a wine producing company representing the products of 9 cooperative wineries in the Province of Treviso with over 5000 winegrowers on vineyards extending over approximately 10.000 hectares. The majority of these lands is cultivated with Glera, named after the historic variety from which Prosecco is obtained.
The company is named for its place of origin, La Marca Trevigiana (March of Treviso), located in the heart of the Province of Treviso, between the plains and hills of the Conegliano-Valdobbiadene Doc and DOCG areas (Controlled Designation of Origin and Controlled and Guaranteed Designation of Origin), where its grapes are grown.
Know-how handed down through the years, experience and winegrowing professionalism, sectorial expertise and dynamic commercial strategies are the keystones that make it one of the most representative and visible companies in the Prosecco world.
La Marca is committed to uniting tradition with innovation, as well as native know-how with advanced technology. In addition to working for a sustainable viticulture that thinks about protecting future generations, they also believe in respecting natural resources which ensure characteristic wines that are strongly rooted in the territory.
La Marca markets white and red wines, Prosecco DOC, Prosecco Treviso and Prosecco Conegliano Valdobbiandene DOCG, under the brand-names of La Marca, Millage, Foscaro, San Nicola and Torri Della Marca.
- Glera
- Pinot Blanco
- Chardonnay
- Cabernet
- Merlot
- Verduzzo
- Cabernet Piave DOC
- Merlot Piave DOC
- Chardonnay Piave DOC
- Pinot Grigio Piave DOC
- Verduzzo Piave DOC
- Conegliano Valdobbiadene Prosecco Superiore DOCG – Extra Dry
- Valdobbiadene Prosecco Superiore DOCG Millesimato – Brut
- Prosecco DOC Treviso – Extra Dry
La Marca Vini e Spumanti, Via Baite, Oderzo, Province of Treviso, Italy
La Marca Vini e Spumanti, Via Baite, Oderzo, Province of Treviso, Italy


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When it comes to projects around the house or property, it is important to have all the tools you need. Having the proper tools ensures the job is done properly and efficiently. It can also be a safety issue. If you do not have the proper tools, it means you are improvising. While improvising is okay in certain situations, in others it can be a real danger to yourself or those around you. Not to mention, using the wrong tools or inadequate tools can cause damage to the tool itself and to the property. Many accidents occur every year from people working in high places without the proper equipment. Fortunately, there is a solution to this problem.
Dangers of Working in High Places
There are inherent dangers that come with high places, such as roofs and such. However, there are times when work needs to be done in places that require a ladder and additional safety equipment to access safely. For many people this is a one-time chore, so they don't see the need in wasting money to buy equipment they will not use again.
This is understandable, but it still doesn't make it safer to improvise to reach the high up area that you need to reach and work on. This is where tool rental companies come in handy. This allows you the ability to rent the equipment that you need to safely complete the job, without wasting the money to purchase a tool you will only use once. It's a win-win. There are many different rental options available depending on your needs and the project that you are working on.
Tool Rental Services
When working in high up areas, ladders are the most common piece of equipment thought of. In reality, scaffold towers are the safest alternative to using a ladder to work above ground level. Scaffold towers offer more stability, versatility, and work space than ladders. For those who do not like heights, scaffold towers are your best option. Different sizes are available depending on the height and size of the project that you are working on.
The friendly staff offers a variety of ladders of all different sizes and styles to match your project and height needs. Additional tools such as hole borers, door trimmers, tile lifters, and much more are available for rent as well.
The rental company offers equipment for both residential and commercial projects. If you are unsure of what you need to complete the job, the friendly staff is happy to discuss you needs and recommend products based on the scope of your project, your individual needs, and preferences. They even offer delivery and pick up of the equipment if you are unable to pick it up yourself. If you find yourself in a pinch, there are cases in which the equipment can be delivered the very next day.
The professionals strive to make sure that you have every piece of equipment that you need to get the job done right with the least amount of hassle possible!


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Custom Homes
Create. Collaborate. Construct.
At TIMELINE, we design and build houses you can't wait to come home to. Our in-house team of architects, project managers, interior designers and craftsmen work together to create a custom home designed just for you. We focus on every detail so you can simply live and love the life you've built, in the home we've built, together.
Every custom home project begins with a great design. Whether you have your own architect, or are using our architecture and interior design teams, we will help ensure the very best solutions for your dream home, both inside and out. Because we are a design and build firm, we are able to offer a unique blend of creative solutions for interior space planning, kitchen and bath design, and overall layout. Our craftsmen pay close attention to every detail to ensure a quality, on-time build.
Building a new home may seem overwhelming, but at Timeline, we are able to minimize the stress. From conceptual designs all the way through building completion, you'll love our thorough process getting you in your dream space quickly with the least amount of disruption to your life. Our time tested design-build process breaks down every step to increase communication, anticipate every detail, and deliver your new home on time and on budget. Whether you're building a custom home, getting a kitchen remodel done, or going for an addition, you'll love our proven building process. It takes your needs into account, and offers a vast improvement over dealing with multiple firms for different phases of your home building project.
Looking at purchasing a lot ?
We offer free consultations with homeowners and REALTORS to provide feasibility studies prior to your purchase of homes and land. This way you get a clear idea of what the cost of building will be BEFORE you purchase the land. By putting our decades of experience at your disposal, we can save you from making costly errors by citing potential difficulties with the lot for building, and help you budget correctly for your land AND your build.
Have a lot and are ready to build?
Maybe you already have your lot selected, and you can't wait to get your new home built! There's nothing like the planning and anticipation that comes with building a new custom home! Take a look at some of the custom homes we've designed in the Saratoga, CA, area for inspiration and contact us to get started.


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Sci. Aging Knowl. Environ., 24 April 2002
Picture This: NMR provides a glimpse of amyloid fibrils (Amyloid; Structural biology)
R. John Davenporthttp://sageke.sciencemag.org/cgi/content/abstract/sageke;2002/16/nw56
Key Words: amyloid 2-microglobulin Alzheimer's disease Parkinson's disease NMR
Abstract: Protein clumps called amyloid fibrils crop up in numerous neurodegenerative diseases. But their structural details--which could reveal how they form and why they're linked to trouble--remain fuzzy. Now, two independent reports help bring amyloid fibrils into focus.
Although proteins that compose amyloid fibrils vary in amino acid sequence, the fibrils assume similar shapes: They all contain extensive strands, peptide ribbons that lock together through hydrogen bonding. Because they are big, fibrils have escaped high-resolution scrutiny. In the new work, both groups use chemical tricks and nuclear magnetic resonance (NMR)--a technique that probes the chemical environment of atoms in a molecule--to follow the twists and turns of 2-microglobulin, a blood protein that deposits amyloid in kidney dialysis patients.
Putting many amyloid proteins--including 2-microglobulin--at low pH accelerates fibril growth, perhaps by shifting the protein partway toward the solid state. To determine the shape of this intermediate form, McParland and colleagues used NMR to assess 2-microglobulin's floppiness. At low pH, its ends unfolded readily, but its core remained in strands. This 2-microglobulin intermediate resembles the intermediate form of transthyretin, an unrelated fibril-forming protein, says chemist and structural biologist Jeffrey Kelly of the Scripps Research Institute in La Jolla, California. The results hint that different amyloid proteins undergo similar structural changes as they make fibrils and support the idea that amyloid proteins unfold partially before congregating. What's still unclear, says Kelly, is whether the unfolded or the folded part is crucial for assembly.
In another study, Hoshino and colleagues probed the shape of 2-microglobulin fibrils. They plopped fibrils into heavy water. Deuterium atoms replace accessible hydrogen atoms in the protein but can't switch with hydrogen atoms tied up in bonds between amino acids. Then the researchers used dimethyl sulfoxide to stop the exchange of hydrogen and deuterium and dissolve the aggregates into unfolded proteins that are small enough to examine by NMR. The two-step process--first swapping accessible hydrogens in the aggregated state with deuterium and then analyzing the dispersed proteins to find the sites of exchange--is a "clever way" to study a structure that is too large for NMR, says Kelly. In the fibril, 2-microglobulin's ends open up, whereas normally free loops in the core regions become protected, perhaps by forming strands. The researchers conclude that each protein in the amyloid fibril adopts a more extensive network of strands than it does in its soluble condition, lending fibrils their rigidity and resistance to aggregate-busting enzymes.
The two studies together suggest that pliant ends and rigid centers allow proteins to cluster into amyloid fibrils. Whether this new structural information will generally apply awaits further study. "We need to look at a large number of the other [amyloid-forming] proteins," says Kelly. Mounting evidence suggests that small clumps that arise early in the aggregation process trigger disease. Researchers hope that understanding the shape of proteins in amyloid fibrils--and how they morph to get there--will help uncover ways to prevent the vexing coalescence.
--R. John Davenport
M. Hoshino, H. Katou, Y. Hagihara, K. Hasegawa, H. Naiki, Y. Goto, Mapping the core of the 2-microglobulin amyloid fibril by H/D exchange. Nat. Struct. Biol., 22 April 2002 [e-pub ahead of print]. [Abstract] [Full Text]
V. J. McParland, A. P. Kalverda, S. W. Homans, S. E. Radford, Structural properties of an amyloid precursor of 2-microglobulin. Nat. Struct. Biol., 22 April 2002 [e-pub ahead of print]. [Abstract] [Full Text]
Citation: R. J. Davenport, Picture This: NMR provides a glimpse of amyloid fibrils (Amyloid; Structural biology). Science's SAGE KE (24 April 2002), http://sageke.sciencemag.org/cgi/content/abstract/sageke;2002/16/nw56
Science of Aging Knowledge Environment. ISSN 1539-6150


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George Clinton & Parliament Funkadelic @ Taste of Chicago (pics)
While George Clinton has announced he's retiring from touring at the end of the year, he's definitely keeping himself more than busy until then. He and Parliament Funkadelic's tour schedule is packed, and they recently closed out the five-day A Taste of Chicago festival in Grant Park on Sunday (7/15). (Black Star headlined Friday.) Pictures from their set are in the gallery above.
George will land the Mothership on an actual ship in NYC, playing a Rocks Off Concert Cruise on August 3 (tickets). Updated tour dates are listed below.
George Clinton & Parliament Funkadelic – 2018 Tour dates
AUG 01 – The Ardmore Music Hall – Ardmore, PA
AUG 04 – Cabot Theater – Beverly, MA
AUG 05 – Newport Jazz Festival – Newport, RI
AUG 10 – The Tarheel – Jacksonville, NC
AUG 23 – Lyric Theatre – Lexington, KY
AUG 24 – Infinity Downs Farm – Arrington, VA
AUG 25 – Cherry Creek BBQ on the Slope @ Cockaigne Ski Resort – Cherry Creek, NY
AUG 31 – The Novo by Microsoft – Los Angeles, CA
SEP 02 – McMenamins Crystal Ballroom – Portland, OR
SEP 08 – Central Park – Atlanta, GA
OCT 07 – Mempho Festival – Memphis, TN
photos by James Richards IV


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Irish Green wins Superiorland Soccer Association's Under-10 Girls playoff title
Irish Green defeated Maroon 4-3 in the championship game of the Under-10 Girls Division of the Superiorland Soccer Association on July 22 at the Kaufman Fields in Marquette. Maroon is coached by Addie Niemi and Laney Niemi. Irish Green members include, front row from left, Jaime Curry, Wiley Steeland, Allison Kreis, Anna Tuccini, Madeline Bohl, Annmarie Messina and Emily Janowski. Top row from left, Elle DeBolt, Rosalie Wagner, Nora Skytta, Kalyn Carr, Jillian Starr, Lotus Klipp, Alina Nelson and coach Hali Koepp. Not pictured is coach Kylie L'Huillier. (Submitted photo)


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Breast Cancer Resources
Cancer Connect Breast Cancer Community provides current, comprehensive, reliable information on brain cancer and a community where breast cancer patients can exchange information and get support and inspiration.
The mission of the Avon Foundation for Women Breast Health Outreach Program (BHOP) is to link medically underserved women to breast health education and screening services. Low-income, underinsured, and other marginalized populations often need targeted, customized approaches to help them obtain regular mammograms and clinical breast exams.
BCO provides support and information about effective treatment options, informed patient choice and cancer risk reduction. Their email update, Breast Cancer News, has information on Complementary/Alternative Medicine, Environmental Risk Factors as well as traditional medicine choices. They also have a message board, discount vitamin club and much more.
Breast Cancer Research aims to serve as a focus for communication in all areas of biology and medicine relevant to breast cancer, with special emphasis on its genetic, biochemical, and cellular bases.
Offers free, confidential one-to-one support to cancer patients undergoing cancer treatment and their families using trained volunteers who have undergone a similar experience.
Expedition Inspiration raises awareness and money to benefit breast cancer research.
FORCE is a support and information site for women at risk of hereditary breast and ovarian cancer due to family history BRCA genetic status.
Her2Support.org is an online support group for women whose tumors are HER2-Positive.
The IBC Research Foundation is the only cancer research organization which specifically targets inflammatory breast cancer and the research to find its cause. The Foundation has the only literature specifically for IBC: brochures, bookmarks, and an email newsletter, Focus on IBC. The IBC Research Foundation also has three email lists which are for IBC educational and emotional support. Toll free # in U.S. & Canada 1.877.STOP.IBC.
LBBC's mission is to empower all women affected by breast cancer to live as long as possible with the best quality of life.
An Aventis Oncology sponsored support program for women living with recurrent breast cancer.
NBCC is a grassroots advocacy organization dedicated to fighting breast cancer.
The National Breast Cancer Foundation provides information including early signs and symptoms of breast cancer, myths, early detection, breast cancer research and much more.
An African American breast cancer survivor run organization that provides individual/group support; community education, advocacy and research through affiliate chapters nationwide.
The YSC is dedicated to the concerns and issues that are unique to young women and breast cancer. Through action, advocacy and awareness, the YSC seeks to educate the medical, research, breast cancer and legislative communities and to persuade them to address breast cancer in women 40 and under.


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There's just something about chicken wings, you know? They have this irresistible quality that, upon gazing on a new set of recently served chicken, one must dive in, with little regard of how one will look while doing it. Watching someone eat wings is disgusting by all accounts, and as much as we can feel people watching us while gorging on these little bits of bird, we… can't stop ourselves.
Back at Pop Brixton for a second helping (last time wasn't enough), it was time to try Brixton's specialty cooking style, jerk. Mama's Jerk to the rescue, with their incredibly tender, Jerk BBQ Chicken Wings.
Make sure you get sorted with at least 27 napkins, as you'll be needing them after you jump into the slippery mess that is this mountain of saucy poultry. No clue what they put on the sauce, but it's as addictive as any other substance I've tried before. Plus, if you're lucky like I was, you might get more wings than you purchased. Kind of like getting one extra McNugget in your nugget box. Only way better.
If loving jerk chicken means I'm a jerk, then I'm more than happy continuing being one.
Slimy? You'll be licking your fingers all afternoon. And next day's afternoon also.
Satisfying? If only it was a bottomless pit of wings. They go so fast…
Mama's Jerk
Pop Brixton, 49 Brixton Station Road, London SW9 8PQ


text: Jeff Burtoft is as a technical evangelist at Microsoft. Jeff co-authored his first book entitled HTML5 Hacks (O'Reilly Media) and is a founding blogger at html5hacks.com. Jeff is a huge proponent of web standards, and loves all programming languages, as long as they are JavaScript. In his free time, he enjoys writing apps and playing video games with his kids. Read his blog or follow him on Twitter.


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3421 Bannerman Road, #102
Tallahassee, FL 32312
3421 Bannerman Road #102, next to Mom and Dads
Are you ready for a new experience in the Tallahassee, FL - Bannerman Crossing area? We have the answer! Painting with a Twist is a great place to have fun with your friends or meet new friends. Relax, let your hair down, and just be you. Discover your inner artist. Bring your favorite bottle of wine or beverage, and paint along with our artist to create your own work of art that you will take home at the end of the evening.
We provide all painting supplies and artist instructions. No art experience is needed. Simply be ready to have a "twisted" good time! Open classes are fun for you and a friend or small group.
Private Parties for kids are great for groups of 10 or more paid seats. Adult parties weekdays are 10 or more paid seats, weekends are 12 or more paid seats.
Gift Cards make a unique gift for any occasion and are available for purchase online or in the studio.
Follow us on Facebook to hear about studio events, get sneak previews of new art and our monthly calendar, participate in promotions exclusive to Facebook fans, and more!
BYOB permitted for age 21 & up. Family Day & Kids classes are no alcohol permitted.
Evening Classes 18 to party-21 BYOB. 15-18 may attend with a paid adult seat. Kids Classes Age 7+. All persons present in the studio are required to have paid seats. No infants or toddlers in the studio.


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|Sartre seeing against himself.
If you apply the same approach to writing, you get "I write against myself." If you are suspicious of that which comes easily, too easily, you might arrive at something outside yourself, larger than yourself. You might. You might not, but you might.
It's recognizable at readings when a poet/writer is comfortable writing in some certain way. The poems are difficult to distinguish from each other, difficult to distinguish from the poems he/she read at their last reading, or perhaps they've been reading the same poems at successive readings, for successive (gulp) years even. Not only is this a creative bog for the writer, but it's also a wriggling morass for an audience, who can't possibly be expected to be surprised by the same thing again and again and again ad nauseum.
Or, as Frost says: "No surprise for the writer, no surprise for the reader."
Posted by Thomas Walton at 11:30 AM No comments:
Interview Re Issue V
|Magritte's little known painting, Thinking Moustache.
The venerable documentarian Paul E. Nelson has graciously posted an interview with myself and Sierra Nelson re the magazine. You may find it here: Yellow Snow.
Posted by Thomas Walton at 10:26 AM No comments:
Stranger Review
Reading PageBoy might make your face do this! It might transport you to exotic climes (or wherever he is)! So loosen your tie, and put on a pair of (special-spy-issue-unscrambling) sun glasses and read child read!
If you're still unsure, you can find Mr. Constant's review here: Please Amy, Use Lube.
Posted by Thomas Walton at 4:15 PM No comments:
Oh Beautiful Useless
|Gautier: Beautiful or Ugly?
"Only that which serves no end is beautiful; everything useful is ugly."
- Theophile Gautier.
Posted by Thomas Walton at 9:40 PM No comments:
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FONPLATA signs Cooperation Agreement with Georgetown University
(Washington D.C., November 5, 2018) FONPLATA announced the signing of a Memorandum of Understanding with, of Georgetown University's McCourt School of Public Policy in Washington D.C., which establishes a framework for collaboration between both organizations to promote activities in areas of mutual interest.
Acesse aqui a versão em português
The memorandum was signed at McCourt School. Juan E. Notaro, Executive President of FONPLATA, and Michael Bailey, Interim Dean of McCourt School, represented the parties. Ambassadors to the United States for Bolivia, Paraguay and Honduras - Pablo Canedo, Germán Rojas and Marlon Tabora, respectively - were also present.
An internship program for master's students was also launched at this event. The program, mostly intended for students from FONPLATA member countries, aims at developing professional practice in areas such as project evaluation, green bonds issuance, and partnership development, among others.
Notaro highlighted the high collaboration potential of the agreement, considering the ongoing School's initiatives, such as the "Institute of Politics and Public Service" and "the Massive Data Institute," which will enable the development of knowledge exchange forums and activities.


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This content is PDF only. Please click on the PDF icon to access.
Thirty-five papers, read at a symposium held in Philadelphia, concerned with normal anatomy and physiology of the kidney, pathophysiology of renal failure, and clinical aspects of acute and chronic renal failure. This collection has the uneven qualities of many symposium-derived publications. Some papers are relatively fresh in content; others are rehashes of what their authors have said and written better elsewhere many times. Some papers are detailed; others are cursory. Some of the illustrations (chest X rays, tissue sections, etc.) are third-rate. This collection is cheaper than most major current textbooks on renal disease but is no bargain in view
Renal Failure.. Ann Intern Med. 1968;68:973. doi: https://doi.org/10.7326/0003-4819-68-4-973_5
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© 2020
Published: Ann Intern Med. 1968;68(4):973.
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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$9.99 - $7.97
(as of Nov 07,2019 12:30:33 UTC – Details)
The gift pack assortment includes a variety of Matchbox vehicles to keep kids entertained! Each pack comes with an exclusive vehicle featuring decos you won't find anywhere else in the entire Matchbox line! Nine stunning cars are in every set. Collect all the sets and showcase the ultimate fleet! Each pack sold separately, subject to availability. Not for use with some Matchbox sets. Colors and decorations may vary.The perfect gift for vehicle lovers of all ages
Speed and action all in a pack of 9 die-cast Matchbox cars
9 of the coolest 1:64 scale die-cast vehicles; each pack is an instant collection
Includes 1 exclusive decoration car, not available anywhere else
Ships in randomly selected, assorted styles according to availability


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Most famous for his 24 novels about the Napoleonic War-era rifleman Richard Sharpe, Bernard Cornwell is perhaps the world's best-known historical novelist today. Fantastically prolific, Cornwell has over 50 novels to his name, and has sold millions of books to fans across the world. He regularly tops bestseller lists in Germany and Scandinavia, and is, much to his bemusement, afforded rock star status in Latin America. A recognised master of both grand war and the individual do-or-die decisions present in the lives of many of history's less celebrated figures, Cornwell's books mostly deal in the high-octane environments found where arrows whir or cannons pound: he declares himself to be primarily an entertainer. The Saint talked to Bernard Cornwell over email, as part of a long-running project aspiring to discuss the same set of interesting topics with writers of different backgrounds.
The Saint: To what extent do you think a reader can read one of your books, or a book of any writer, and come to understand the writer as well as the book? How much of "you" goes into any piece of work?
Bernard Cornwell: Oh God, you'd be better off asking my wife about that! How much of "me" goes into any piece? A lot, I suspect, but it isn't a conscious self-portrait, indeed it probably isn't any kind of "selfie." Some years ago I wrote a series of forewords for new editions of Forester's Hornblower series and did some research into the man himself. One of the questions that haunts Forester's fans is "who is Hornblower based on?" and various answers are put forward — plausibly Lord Cochrane or, more likely, Edward Pellew, but it finally struck me that Hornblower was, of course, based on Forester himself, not the Forester the world saw, but rather the person Forester wanted to be. So yes, we all put ourselves into our books to a greater or lesser extent, but transmute the picture with imagination, hope and (I assume) charity. That said, Richard Sharpe is incredibly grumpy first thing in the morning and so am I.
TS: What motivates you to write? Or to put it another way — what prevents you from not writing?
BC: I used to say "the mortgage," and there's some truth in that, though that motivation has long ceased to exist. So while I think what to answer you I'll quote from the opening monologue of Neil Simons's The Good Doctor . . . the narrator (unnamed) is Anton Chekhov . . . and I'm quoting from memory . . . "What force is it that compels me to write day after day, page after page, story after story? And the answer is quite simple, I have no choice, I am a writer. Sometimes I think I must be mad. . ."
To claim that for myself is a bit pretentious so my usual (glib) answer is that writing is better than working. So what motivates me? I enjoy it! I make up stories, I live in a world of my own devising and I'm lucky enough to have readers. There is a responsibility towards those readers. They want a new book every year and I see no reason to deny them. And I can't imagine what on earth I'd do with my time if I didn't write! Am I driven by some mysterious force? No, but I'm not trying to write literature. I write adventure stories. My only cause is to entertain and, I hope, amuse my readers. That's not very elevated, but, trust me, it's better than working.
TS: What do you consider success to be — by what metric do you say whether you consider a work successful? How does your view on success and life outside of your work influence your aims within your work?
BC: You know! You just know! We are each of us our own most perceptive critic, or I should hope we are! Success is to be happy with the end result. Of course it helps if the book sells; there's little so debilitating as nagging poverty, but I take no notice of sales figures. You might say I don't need to, and you're right, but the only metric for me is knowing I succeeded in doing what I set out to do. Did I enjoy writing the book? Then probably the reader will enjoy reading it. My view on success and life outside my work? I'm fortunate in a most happy marriage, good friends, a (relatively) clear conscience, a quite wonderful dog and a good supply of Irish Whiskey.
TS: Why do you work in the mediums in which you do? What draws you to them, and makes you prefer them to the others available?
BC: I suppose we write what we want to read? As a teenager I loved the Hornblower stories and that led to a love of historical novels and I never really thought of writing anything else. I'm not clever enough to write analyses of the human condition, I'm not a great reader of literary novels (whatever the hell they are, and yes, I do read some which probably qualify) and though I love and collect poetry I don't have the first idea how to write it, I can't paint, I'm tone deaf, and wtf is left? Many years ago I saw a blonde walk out of a lift in Edinburgh and said to my companion, 'I'm going to marry that one.' Well, she was an American, I was British and she couldn't live in the UK for family reasons and I couldn't get a work permit in the States so I said 'I'll write a book'. Thirty-nine years later we're still married. Desperation drove me to write that book and, as it happens, it was the only kind of book I could write. Not much choice, really!
TS: As a writer, you have what some might call a very privileged position of access to the reader on a personal level. Do you feel like you, and writers generally, ought to use that position to advance what you consider to be right, whether through your writing or outside it?
BC: My moral duty as a writer? Oh dear God, I write adventure stories! I suppose I could be accused of glorifying war (I hope not), and my rather specious response is to say that Agatha Christie wasn't glorifying murder. We certainly have a moral responsibility, but so does every person alive, though I accept that our access to a large number of readers deepens our responsibility. I try to be good! I also try to entertain my reader without corrupting their morals. Up to a point, anyway.
TS: To what extent do you think the reader or critic ought to consider the author and the author's intentions and beliefs when they read something written? Do you ever feel like your original intentions are being misconstrued in any way — and do you think it matters if they are?
BC: Oh I don't think that I, as a writer, have the right to demand anything of the reader! And yes, I have been misconstrued. Some years ago a white supremacy group took some of my words out of context and splashed them all over the home page of their website. I demanded that they take the quote down (which was taken from a novel set in the 10th Century about the making of England and was hardly relevant to 20th Century Bradford), which eventually they did, but only after giving my email address to their members and for two or three months I was a target for scores of morons. It got tiresome after a while, but so it goes. It's stopped now.
TS: Ernest Hemingway declared that 'The writer's job is to tell the truth.' What, for you, makes a novel, a poem, a play —– any piece of written work — a good one?
BC: Did I enjoy it?
TS: What have you found to be the greatest challenges in making your own work good by that standard, and how have you sought to overcome them?
BC: Making the plot work is the hardest thing. I've heard it said that writing is easy, writing well is a bit harder, but knowing what to write about is really difficult. I think shaping the narrative is the challenge. It's all about motivating the characters and manipulating their environment so that the choices they make convince the reader that it was the best choice in the circumstances. But all I'm doing is writing stories! I read, say, Annie Proulx (and yes I do!) and understand that she's shooting at a very small target a long way off while I'm shooting at a barn door with a shotgun at five paces. Even so, making the plot work is hard!
TS: How would you like your legacy to be looked upon?
BC: I'm not running in the Posterity Stakes! There won't be a legacy.
TS: What is the work of which you are most proud — and similarly, if only one of your works could survive for posterity, which would you choose to save?
BC: Probably Fools and Mortals. It's my most recent book and I do like it. It's very different to everything else I've written . . . a fictional tale about the first production of A Midsummer Night's Dream. I spend my summers acting in a Summer Stock theatre on Cape Cod so the book springs out of that experience and from a love of Shakespeare. I can't think of another novel that has tried to describe the atmosphere and excitement of London's first professional theatres, and I think I managed to write Will Shakespeare some dialogue without making a complete ass of myself.
TS: If there was anybody from history that you would wish to be pleased by, or proud of, your books, who would it be?
BC: Nell Gwynne. She was as generous as she was lovely. [Ed.: Eleanor "Nell" Gwyn, who lived from 1650 to 1687, was among the leading actresses of the English Restoration period, and was for many years the mistress of Charles II].


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Applicant tracking systems (ATS') are a must-have for HR teams who want to centralize and standardize their hiring processes, plus keep tabs on the status of all their candidates. They make these common processes easier for everyone, and eliminate the need for manual tracking in spreadsheets or juggling multiple applications.
If your organization doesn't yet have an ATS (or is looking to upgrade), the research process may seem overwhelming: there are a lot of options and competing opinions. But if you can decide what features are most important for you and your company, you can narrow down your choices and choose the one that's best-suited to meet your recruiting needs.
What should your HR team prioritize in an ATS?
Before you consider the following seven characteristics shared by the top applicant tracking systems, consider the needs of your team and where you see your organization in the future. Most modern HR departments need the same things in their applicant tracking and recruitment software, including:
- A centralized database for all hiring-related information
- A more intuitive experience for everyone (including candidates)
- Better reengagement of prior candidates
- Easier posting of job ads to multiple locations
- Integration with frequently used tools
Which of these features do you need the most from an ATS now, and what features will you need to take your company to the next level? Prioritize them. Once you do this, you'll be ready to consider which applicant tracking system is right for you.


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Monday, March 1, 2010
Kristi Zarifeh takes the gold in Greymouth!
Westports' Anthony Hema and Sumners' Kristi Zarifeh have won the Mens and Womens' 1/2 ounce pure gold in Greymouth.
Hema won the Open Mens in trying conditions, 3-4 ft low tide sweep at The Channel near the Cobden breakwater. With two high sixes, Hema took the Gold and dedicating his win to his late father. 2nd was Christchurch's and defending champ Hayden Brain, with the highest wave score in the final could not back up the score during the 30min final, until 15 seconds after and caught a wave that could possibly been the score he needed. 3rd was Kaikoura's Sam Dunfoy, who took a early lead, and in 4th, Craig Grimshaw who seemed to have been sweeped 100metres north due the river like drift.
Seventhwave team rider Kristi Zarifeh started with a great opening wave which proved too much for her fellow competitors, taking home the win and the gold. Congrats to her, Alethea Lock and all the other competitors. More pics and video to follow.
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Also found in: Thesaurus, Idioms, Wikipedia.
Related to hurrier: fresh
hur·ry(hûr′ē, hŭr′-)
v. hur·ried, hur·ry·ing, hur·ries
To move or act with speed or haste. See Synonyms at speed.
1. To cause to move or act with speed or haste: hurried the children to school.
2. To cause to move or act with undue haste; rush: was hurried into marriage.
3. To speed the progress or completion of; expedite: hurried the delivery of the product.
n. pl. hur·ries
1. Activity or motion that is often unduly hurried; haste: I forgot my gloves in my hurry to catch the bus. See Synonyms at haste.
2. The need or wish to hurry; a condition of urgency: in no hurry to leave.
[Possibly Middle English horien, perhaps variant of harien, to harass; see harry.]
hur′ri·er n.
1. a person who hurries
2. (Mining & Quarrying) (formerly) a child employed in a coal mine to haul baskets or carts of coal from the coal face to the surface


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Speaking at a military conference in Maryland, Tuesday Gen. Raymond Thomas U.S. Special Operations Command chief told attendees: "I think we are staying focused" on the task at hand, when he was asked if the surprise resignation of the National Security Adviser Michael Flynn has created any confusion or concern within the command.
He also added that the US and its allies had eliminated more than 60,000 ISIS fighters.
"We have killed over 60,000," he said characteristically.
Asked by military.com if the raid in Yemen on Jan. 19 where the U.S. forces suffered a combat casualty with the death of Senior Chief William "Ryan" Owens was hastily planned he responded that those accusations are "absolutely incorrect."
"I don't think that there's awareness in the great American public that we're a country at war, that ISIL and al-Qaida are in countless countries," he said, using an acronym for the Islamic State. "That an operation like Yemen is what goes on any given night out there. And unfortunately it wasn't in that context."
However, Gen. Thomas did note that Mr. Flynn's abrupt departure was indicative of the underlying commotion that White House has been in recent weeks.
"Our government continues to be in unbelievable turmoil. I hope they sort it out soon because we're a nation at war."
Thomas oversees America's elite Special Operations troops, including Special Mission Units, Army Green Berets, and Navy SEALs which have played a huge role in combating the terror organization, with raids against key leaders.


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TMSR Stock Forecast - Get a free TMSR stock predictions and find out whether you should buy or sell TMSR stock. The trend analysis tool will help you make a better prediction on the TMSR stock.
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Feel Your Best With Expert Chiropractic Care In Westmount, Edmonton
Contact us today for your FREE consultation!
Call (780) 452-6172 or book your appointment online now.
We offer same day appointments and direct billing to most insurance companies so you can prioritize your health with ease and convenience.
Discover Relief From Pain With Expert Chiropractic Care
Are your suffering from any of the following conditions?
- Back pain
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Our patients range in age from babies up to senior citizens. Our team's mission is to help you regain your health because you deserve to live without discomfort.
Get effective, personalised treatment for your pain.
Call (780) 452-6172 now to book your consultation.
Our Patients Love The Action Chiropractic & Massage Therapy Clinic Experience
The treatments are excellent and enjoy coming. I highly recommend others to come to clinic.
Just a helpful and hopeful atmosphere all around. This place makes you feel like you WILL get better over time.
Honest people with very professional welcoming smiling face.
Thank you Dr. Chan for getting our backs fixed.
Friendly receptionist and Dr.Chan was very accommodating & very clear about explaining everything. :)
I think you guys are doing a great job!
Excellent first visit. I am happy I made the decision to come. I look forward to the next few visits, and am confident I will experience a great outcome.
Very professional staff and helpful. Always a very comforting experience and everything with a smile.
I have been coming for years and am very grateful to have you in my life.
Instant pain relief on my lower back, thanks Dr. Chan.
All the healthcare professionals were very kind and helpful! It was overall a very good experience.
I felt confident I was in capable hands.
Friendly Staff, Office very Neat & Clean. Calming Atmoshere all made my first experience a Excellent One
Very excited to see my progress through treatments planned!
I am happy to be receiving care from such competent and professional people. Kenny is extremely friendly, Kim is always kind and helpful, and Serika was great.
You and your staff Ken are very professional, helpful and courteous. Thanks for all the help you've given over the years. I'll be moving to Vancouver Island later on this year. Thanks again.
Friendly and welcoming staff – thoroughly enjoyed my visit and will be back!
I really appreciate the comprehensive approach at Action Chiropractic & Massage Therapy Clinic. I feel like they care about my complete wellbeing.
Very professional practice. You always leave feeling like the team cares about your health.
Great experience, professional and knowledgeable.
Thanks for being there for me!!
Very excited to see my progress through treatments planned!
The support staff and Dr. Chan are wonderful! I felt that I was in very good hands as I was in a painful, vulnerable state my first visit. I felt safe, cared for and welcomed! I am now on the road to recovery- thank you!
Great people. Very nice and approachable. Highly recommended.
I had severe shoulder and neck pain, I only had one visit and already feel better. I look forward to continuing to see Dr. Chan.
Thank you for doing what 4 doctors couldn't, provide an answer and a treatment plan!
Dr. CHAN, ERICA, Kim and the rest of the staff were professional and sincere. I've had treatments here before and wouldn't try another place.
The entire staff was a pleasure.
Schedule Your Appointment Today


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How to ease lower back pain [news]
Lower back pain can impact every part of your life. But you don't have take it lying down. It can happen to anyone. You'll be sitting at your desk working away, when suddenly, you feel a dull ache in your lower back. What do you do? More often than not, you'll probably keep working and just ignore it. Or if it gets worse, you may get up for a quick stretch – hoping that will do the trick.
It's highly likely that in our lifetime, we'll experience some degree of lower back pain. About 70 per cent of adult New Zealanders has had back pain at some stage. Unfortunately, there's no magic pill to cure lower back pain, but exercising for a strong, healthy back can be a preventative measure, which makes it a must for everyone.
read more


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- 1
- Unit/Units
Bearing Fault Frequency Data Software - Bearing Expert
The Bearing ExpertTM is a modular PC based interchange and vibration frequency database. This unique PC driven software tool compliments in-house maintenance, engineering, and vibration analysis tasks by providing immediate access to bearing, oil seal, and vibration data for all current and past manufacturers of these products. This product is the result of years of research and experience by engineering and MRO professionals like you. The tool is designed from the user perspective and is quick, easy to use, and brings significant immediate cost savings to the plant environment.
Vibration Process
The Bearing ExpertTM provides an automatic Multiple Manufacturer Vibration Frequency Report. It is the only product that can produce multiple frequencies with one request and is the largest vibration frequency database available worldwide. The Multiple Manufacturer Vibration Report is generated from the same initial request for interchange data and requires no additional steps. The frequencies are calculated at the RPM (Revolutions per Minute) or CPS (Cycles per Second) value the user specifies. In conjunction with the Multiple Manufacturer Vibration Report, The Bearing Expert also features the Harmonics Report. The user may select the number of times they would like to have the frequencies calculated for each report. The default is for 10x's Harmonics.
The Bearing ExpertTM is the source for Vibration Frequencies. It has the support of leading Condition Monitoring Software Providers, Consultants, and Bearing Manufacturers alike. The database is updated on an annual basis.
Ease of Use
The Bearing Expert Database requires no training. Easy to use Menu features walk you through the search options and report options. The intuitive search engine enables you to select part numbers based upon your current knowledge of the bearing in question. You input the data you have available to you. The Bearing Expert will help you narrow your selections. No research is necessary to locate the data for your part number. The Site Link Search options provide you with data points for multiple manufacturers allowing you to compare and analyse the data presented to best suit your requirements. The new Prefix and Suffix Descriptions are displayed to further assist you in breaking down the part number in question to meaningful data searches. Just a few simple keystrokes will complete your search.
· 1 Million Bearings in Interchange
· 200,000 Vibration Frequencies
· Reduce Unplanned Downtime/Optimize Design Cost
· Reduce Duplicate Inventory
· Cuts research time and efforts by 95%
· No Need to wait for Manufacturer for frequency data
· Compatible with ALL Condition Monitoring Software
· When a bearing fails, it provides an interchange report that identifies bearing in stock or alternative choices available from suppliers from replacement
- Telegraphic Transfer (T/T), Cheque, Cash Advance (CA)
- 10000 Per Week
- 1 Week
- All India
D - 998, First Floor, Palam Extn., Sector-7, New Delhi, Delhi, 110077, India
Phone :+918068090079


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What Is ChexSystems?
If you've been reported by a bank, you may be rejected for an account
ChexSystems is a database that banks use to determine if potential customers might present too much risk to the bank. It is owned by Fidelity National Information Services, which provides banking software and other technological support for financial institutions. Services provided by ChexSystems fall under the regulation of the Fair Credit Reporting Act.
A similar service is provided by Early Warning, which is owned jointly by Bank of America, Branch Banking & Trust, Capital One, JPMorgan Chase Bank, PNC Bank, U.S. Bank, and Wells Fargo Bank.
What Banks Report
ChexSystems is different from a credit report, which establishes a history of good and bad behavior. Instead, the only things banks report to ChexSystems are problems they had with account holders, and ChexSystems establishes risk scores for consumers that range from 100 to 899. Examples of reasons why banks might report someone to ChexSystem include:
- Accounts closed for cause: A bank will close an account if it has been used to commit fraud or if the account holder continuously writes bad checks.
- Bounced checks/overdrafts: One mistake likely won't be a problem, but account holders that repeatedly make this same mistake are likely to be reported.
- Debit card/ATM abuse: This includes fraudulent activity such as depositing empty envelopes when making a deposit at an ATM.
- Excessive account applications: Applying for multiple accounts in a short period of time can be a red flag for potentially fraudulent activity.
- Excessive loss of checks/debit cards: A rare lost checkbook or ATM card is not likely to get reported, but someone who reports these stolen repeatedly could be flagged for potential fraud.
- Suspected fraud or identity theft: Using the account for any kind of criminal activity.
- Unpaid negative balances: Again, a single mistake or a negative balance for a day or two is not likely to result in being reported. Failing to address the problem in a reasonable amount of time, however, is likely to get an account holder reported.
Information can stay on your ChexSystems record for five years.
Defining Account Abuse
Reporting agencies like ChexSystems exist to protect banks from consumers who abuse bank accounts to the point of creating financial risk for any bank that allows them to open an account. However, what constitutes abuse is not clearly defined and ChexSystems does not share its methods for scoring with consumers.
In 2015, New York Attorney General Eric Schneiderman challenged banks to change the way they screened potential customers, arguing that poor people were more likely to generate negative reports, even for relatively minor mistakes. For example, if an account holder overdraws his account and cannot afford the overdraft fee, additional fees could pile up, creating a negative balance in the hundreds of dollars for what might have started out as an overdraft of only a few dollars.
Banks argue that account holders who repeatedly accrue negative balances unfairly benefit from overdrawn accounts.
Most major banks ultimately reached agreements with New York in 2015, but consumers still need to be aware that banks are tracking everything they do with their accounts, and negative balances can create major headaches down the road.
Getting Reported: Consequences
Some banks won't accept you as a customer if you have been reported to ChexSystems. Other banks will allow you to open an account if you have proof that you have paid off a balance you owed the other bank.
Some banks might offer you an account with higher fees, which help to offset the bank's risk of having a customer with previous mistakes. You also may have to do without a checking account while taking other actions to show that you are more responsible with your money.
If you have a negative report, you can work with ChexSystems or the reporting bank to clear up your report as quickly as possible.
Accessing Your File
You can request a report from ChexSystems if you have been denied an account in the last 60 days. Ask the bank to give you information on how to receive a report or visit the ChexSystem website. You should receive the report in about five business days, allowing you to see the specific claims made against you. You also can request your score.
When you pay off any owed amounts, request that the bank send in a report to verify the account has been paid. You also can request a letter stating this and take it to the bank where you are trying to open an account. You can dispute any information by contacting ChexSystems as well.
Avoid Being Reported
If you have a negative account balance you can't pay right away, some banks might work with you as long as you contact them in a timely manner and make a genuine effort to bring your account back into the positive. This works best if you communicate with your bank in person at the branch.
Make it a priority to stop the overdraft cycle as quickly as possible so it does not become a constant problem and risk. Balance your checking account regularly, and stick to a written budget to avoid overspending your balance in the future. The best way to avoid having a ChexSystems report is to manage your bank accounts responsibly. Most overdrafts happen when people don't track their spending closely enough.
Clearing Up Issues
Take a proactive approach if you've been reported to ChexSystems. Contact the bank immediately to begin repairing the problem. If you cannot pay off all of the money you owe to the bank at once, you might be able to set up a payment plan with the bank.
Once the money is paid off, the bank should report it to ChexSystems so your report can show that the debt is paid off. A bank may be willing to work with you at this point, and a smaller local bank or credit union may be more open to working with someone who's had issues reported to ChexSystems.
Managing Without a Checking Account
It can be challenging to get by without using a bank for electronic access to your money. You could make do with a savings account for a short time, but your banking fees likely will increase.
While addressing your report with ChexSystems, you'll have to monitor your spending more closely and pay bills with money orders or prepaid credit cards.


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In another indication of the increasing regional diversity of the photovoltaic market, NPD Solarbuzz has predicted that demand from MEA countries will grow at a stellar rate in 2013. The region is predicted to grow to a 1 GW market, with South Africa, Israel and Saudi Arabia leading the way.
The NPD publication, the Middle East and Africa PV Market Report, sets out photovoltaic market growth to 2017 in the region, with estimates that the market could grow to 3.7 GW up to 9 GW over that period.
Historically, the MEA region lagged behind global PV markets but is starting to catch up, said Susanne von Aichberger, analyst at NPD Solarbuzz. The report notes that while the MEA region accounts for 17% of the global population, it delivered on 0.5% of photovoltaic demand in 2012. By contrast, in 2017 NPD Solarbuzz predicts demand from the region will account for 6% of global photovoltaic production.
South Africa remains one of the leaders in photovoltaic growth in the MEA, the report notes, with the Renewable Energy Independent Power Producer Program (REIPPP) delivering a 1 GW project pipeline to be installed by the end of 2014. 1.45 GW will be added in total under the scheme.
Israel follows as the next significant market, driven by quotas, tenders and a new net metering scheme. Together the two countries account for 80% of photovoltaic demand in the MEA region.
Saudi Arabia is the third market in the region highlighted by NPD Solarbuzz, with the analysts citing the countrys renewable purchase program as a driver behind the country growing to be the regions largest by 2017. Saudi Arabia has set a target of 16 GW of photovoltaic capacity by 2032.
Despite the current dominance of the South Africa, Israel and Saudi Arabia at present, NPD Solarbuzz predicts their market share in the MEA region will drop below 50% in the future. Ground mounted applications as forecast to account for 70% of demand in the region by 2017.


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Yankwitt LLP successfully moved for summary judgment to dismiss all claims against Golden Nugget Atlantic City, LLC, in a personal injury action brought in New Jersey Superior Court, Atlantic County. Plaintiff lacerated his hands when he ran his fingers along the bottom of a manual paper towel dispenser while intoxicated thinking the dispenser was automatic. In its motion, Yankwitt LLP argued Plaintiff had not proffered any evidence that the paper towel dispenser was dangerous or defective and Golden Nugget should not be held liable for Plaintiff's own foolish behavior. On February 16, 2018, the Court agreed and granted the motion for summary judgment, finding Plaintiff had not satisfied his burden of establishing Golden Nugget breached its duty of care to him and, therefore, Plaintiff's negligence claim must be dismissed.
The case is Vincent Harris v. Landry's, Inc. d/b/a Golden Nugget Atlantic City, et al., (Docket No. ATL-L-1371-16).


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5G Internet or fifth Generation will download HD movie in 1 second
Kabul-Afghanistan (PMG):
Reporter: Soraya Ahadi
The fifth generation or 5G Internet is set to launch a new revolution in wireless data transmission. In the latest case, Huawei and Samsung have announced that their mobile phones will be capable of connecting to 5G networks this year before the launch of the Mobile World Congress.
According to foreign media reports, the new generation of Internet users will be able to download a high-quality movie which is downloaded in the fourth generation of the Internet in ten minutes, in this generation they would download in 1 second. More on this technology to the doctors would be able to have the opportunity to remotely manage the surgery and provide a virtual area of urban areas to create smart cities.


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Welcome to Yorkshire
Farnley Estates gives a Welcome to Yorkshire
Farnley Estates has joined Welcome to Yorkshire, the organisation that is dedicated to promoting the best that our beautiful county has to offer.
As well as showing tourists why Yorkshire is the place to be, Welcome to Yorkshire also gives members the opportunity to link with one another to potentially improve the offer for visitors.
"We genuinely believe that we have some of the most stunning countryside in Yorkshire around here. As part of our 25-year plan, the aim is to open more of our land to even more people for education, leisure, recreation, health and enterprise," says Paul Sykes, Director Farnley Estates.
"By joining Welcome to Yorkshire, we hope to spread the word about the opportunities we have available, here in Farnley. We also feel that we can help to further enhance the opportunities that Yorkshire has to offer both for people living within the county and for those from further afield," Paul adds.


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Jump to navigation
The Hagley Digital Archives provides online access to selected items from the Hagley Library's collection of images, documents, and publications related to the history of business, technology, and society.
Steamboat, Thomas S. Jessup, built for U.S.Q.M. [United States Quarter Master] Department
Length: 130 feet. Beam: 27 feet. Depth: 12 feet 4 in. Two Scotch Boilers. Completed engine #909 - 20 & 40 x 24.
Pusey and Jones Company
SteamboatsShipbuilding industry
Wilmington (Del.)
photographic prints
still image
1 photographic print : b&w
reformatted digital
Audiovisual Collections and Digital Initiatives Department, Hagley Museum and Library
Pusey and Jones Corporation photograph collection (Accession 1972.350)
[Description and dates], Hagley ID, Box/folder number, Pusey and Jones Corporation photograph collection (Accession 1972.350), Audiovisual Collections and Digital Initiatives Department, Hagley Museum and Library, Wilmington, DE 19807
Access to this item is provided for educational and research purposes only. The user assumes responsibility for obtaining permission from the copyright holder to publish or distribute this image. If you would like more information, please contact firstname.lastname@example.com


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Internet addiction is defined by the inability to curb or stop going on the internet, in spite of the damage it causes. Similar to substance abuse, the internet can stimulate the reward center of the brain, leading to addiction. If you find yourself always thinking about internet and have trouble filling personal and professional obligations because of your online activities, you may have an internet addiction. Or, perhaps your use of the internet is causing a strain on your relationships with family and friends? A therapist trained in internet addiction will strive to learn more about your habits to understand the patterns that trigger an episode. They will work to help you identify unhealthy or irrational beliefs that may be contributing to this behavior, and teach you tools to replace the internet with healthy behaviors. Reach out to one of TherapyDen's internet addiction specialists today.
Addiction is defined as "The state of being being given up to some habit or compulsion." Smartphones and the internet are tailored toward keeping your personal interests active. We are in "wild, wild, west" territory here, but while we are in it, we don't have to be of it. There are tools and methods to help regulate this new world. I am in it, of it, and have learned how to help others healthfully modify and recognize and take on compulsive behaviors.— Sandy Marsh, Licensed Marriage & Family Therapist in Los Angeles, CA
Anxiety. It's like the monster that never sleeps. And because of it, you're probably having some trouble in that department too. How many days do you wake up feeling more tired than the day before? It's like you're spinning your wheels trying to get caught up on a never-ending to-do list. And yet somehow, it feels like it's never enough. And it tells you that you're not enough. There's a big difference between feeling a little nervous and totally helpless. I'm talking about that crippling, panic-attack-inducing anxiety that leaves you completely wiped out when it's over. Feeling a little worried over a big event is very different from feeling completely terrified of every event. The good thing is, there's hope. You don't have to keep feeling like your life has no worth and value.— Dr. Zakk Gammon, Therapist in Owensboro, KY
As someone who worked in technology for decades prior to being a therapist, I have a keen understanding of too much Internet use and the problems it can create. I have both professional and personal experience helping my clients to use technology in a way that is helpful and aligned with one's values— Ian Felton, Licensed Professional Counselor in Minneapolis, MN
Many of the people I have worked with were addicted to pornography and other forms of online acting out.— Forest Benedict, Licensed Marriage & Family Therapist in San Diego, CA


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I wanted a way to introduce the people I know (and have met) in San Diego to each other and last weekend I figured out a way - a game of beach volleyball.
Our group consisted of Miles & Claire, their roommate Zack; Andy, Nina, and myself; and Ashton & Beth. We played a few games with mixed teams and had a great time. Even broke out the horseshoes and jumped in the bay a couple of times.
After the beach, we headed to Miles, Claire, and Zack's house to cookout. The feast was magnificent, naturally, and we topped it off by watching the last quarter of the Steelers/Ravens game.


text: Dr. Louis Conte uses digital X-rays to examine your teeth and supporting structures. With digital X-rays, we can quickly and safely view detailed images of your mouth in order to diagnose problems and provide you with the treatments you need. Call Conte Dental today at 732-758-0414 to learn more about digital X-rays in Red Bank, New Jersey, and make your appointment with our dentist.