text:
Author Affiliations
- Tariq I. Mughal1⇑,
- Alessandro M. Vannucchi2,
- Simona Soverini3,
- Alexandra Bazeos4,
- Raoul Tibes5,
- Giuseppe Saglio6,
- Omar Abdel-Wahab7,
- Animesh Pardanani8,
- Rudiger Hehlmann9,
- Tiziano Barbui10,
- Richard Van Etten11,
- Ayalew Tefferi8 and
- John M. Goldman4,*
- 1Tufts Medical Center, Boston, MA, USA
- 2University of Florence, Italy
- 3University of Bologna, Italy
- 4Imperial College London, UK
- 5Mayo Clinic Cancer Center, Scottsdale, AZ, USA
- 6University of Turin, Italy
- 7Memorial Sloane-Kettering Cancer Center, New York, NY, USA
- 8Mayo Clinic, Rochester, MN, USA
- 9Universität Heidelberg, Mannheim, Germany
- 10Ospedali Riuniti, Bergamo, Italy
- 11University of California Irvine, Irvine, CA, USA
- E-mail: tmughal911{at}hotmail.com / tmughal{at}tuftsmedicalcenter.org
Though it has been remarkable to have witnessed the major advances in the understanding of the molecular pathogenesis of the chronic myeloproliferative neoplasms (MPN) over the past three decades, many challenges remain. The advances began with the identification of the BCR-ABL1 gene in chronic myeloid leukemia (CML) in 1985, leading to the introduction of ABL1 tyrosine kinase inhibitors (TKIs), and the JAK2V617F mutation in polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF) in 2005, leading to the JAK inhibitors.1–3 CML is now arguably the most successfully treated human malignancy. Despite these remarkable achievements, the quest for cure, functionally defined as treatment-free remission after discontinuation of TKI therapy, remains difficult.4 In the BCR-ABL1 negative MPNs, a similar degree of success has not been achieved, perhaps because of the rather surprising clonal complexity of these disorders and the increasing molecular evidence of the need for JAK2V617F mutation to cooperate with other genetic aberrations in the initiation and progression of the disease. This clonal complexity needs to be elucidated further in order to recognize clinically relevant candidate therapeutic targets. Herein, we review some of the topical challenges and successes in the biology and therapy of the MPNs that were discussed at the 7th post-American Society of Hematology CML-MPN workshop, which took place in Atlanta on December 11–12, 2012, and up-dated prior to this publication.
1. Unraveling the impact of epigenetics in the classical MPNs
It has been speculated that some of the heterogeneity in CML might be attributable to differences in patients at the epigenetic level. Few studies have addressed the DNA methylome in CML. Dunwell et al. identified two genes (TFAP2 and EBF2) that showed increased methylation at the time of blast crisis, while hypermethylation of the autophagy-related gene ATG16L2 was associated with poorer response to TKI therapy.5 Jelinek et al. studied the incidence of abnormally methylated promoters in 10 selected genes, the frequency of which was shown to increase during advanced phase disease and following resistance to imatinib. They showed that abnormal methylation of the SRC suppressor gene PDLIM4 was associated with shorter overall survival independently of disease phase or imatinib responsiveness.6 A recent study showed aberrant hypermethylation of CEBPA gene promoter and a significant association of this hypermethylation with the CML stage.7
Bazeos et al. collected CD34+ cells from newly diagnosed patients with CML in the chronic phase of disease and compared their DNA methylation profiles with analogous cells collected from the same individuals at the time of achieving at least complete cytogenetic response (CCyR) as well as from healthy controls (A Bazeos et al., personal communication, 2012). Unsupervised hierarchical clustering revealed a series of differentially methylated probes, which were associated with untreated CML and represented a CML signature. Profiles obtained from patients who had achieved CCyR following treatment with tyrosine kinase inhibitors showed similar DNA methylation patterns to those of healthy persons with some residual CML signature marks. The investigators correlated their finding with clinical parameters but were unable to demonstrate major differences in methylation patterns between newly diagnosed individuals and concluded that the CML methylation signature is remarkably homogenous. It is possible that the CML phenotype requires acquisition of a BCR-ABL1 fusion gene in association with a series of specific epigenetic changes.
There is also interest in assessing the relationship between microRNA (miR) expression and CML, particularly in patients who are resistant to TKI treatment. Patients responding to imatinib have demonstrated an increased expression of some miR (−150 and −146a) and decreased expression of other miR (−142, −199b, −145).8 Earlier studies also demonstrated an association between a downregulation of miR-203, possibly due to CpG methylation (or simply genomic instability), and the ABL1 upregulation in newly diagnosed patients.
Studies on the genetic architecture of MPN have discovered an unexpected high level of complexity. Most mutant genes in MPN fall in three functional classes: JAK/STAT signaling (mutations in JAK2, MPL, CBL, LNK, and rare mutations in SOCS), epigenetic gene regulation (TET2, EZH2, ASXL1, DNMT3A, IDH1) and spliceosome factors (SRSF2).9 Patients with MPN who transform to acute myeloid leukemia (AML) often acquire additional mutations, such as TP53, MDM2, IKZF1 and several others.10
Mutations in genes encoding epigenetic regulators are uncommon in MPN and unlike the JAK2 and MPL mutations, which are demonstrable in most, but not all, patients with MPN and correlate with the subtype phenotype, no clear patterns have emerged. Aberrations in ASXL1, EZH2, SRSF2 and IDH1/2 appear to have a predictive impact on the overall and leukemia-free survival, suggesting the notion of the MPN epigenome to be clinically relevant, and the greatest impact appears to be due to ASXL1 mutation.11 Other candidate epigenetic modulators include the CXCR4 promoter acquiring methylation defects, such as those resulting in constitutive migration of CD34+ cells in PMF. Recent studies using genome-wide DNA methylation arrays demonstrate diverse methylation patterns in the various subtypes of MPN, which could motivate efforts to target the MPN epigenome. Nischal et al. showed patients with PV and ET to be characterized by aberrant promoter hypermethylation, in contrast to those with PMF, who exhibit aberrations in both hypo-and hypermethylation.12 Pahl and colleagues have also demonstrated the notion of epigenetic silencing of AML-2 in diverse MPNs, and overexpression of JMJD1C in PV, to contribute in the overexpression of NF-E2 and transformation to AML in murine models.13,14
Furthermore, this seems to be associated with genes, in particular ASXL1, mostly involving inflammatory pathways in PMF, but not PV or ET. It was of interest to note that, in this study, the JAK2V617F mutation did not appear to play a significant role in the MPN-epigenome. There is also much interest stimulated by recent observations of somatic mutations in calreticulin (CALR) gene in JAK2 and MPL unmutated PMF and ET, but not PV.15,16 Much work is now needed to establish the precise molecular and clinical relevance of CALR mutations. Additionally, in vitro studies revealed successful inhibition of the aberrant methylation in PMF-derived cell lines by decitabine, supporting candidacy of this drug for clinical trials. In contrast, Perez et al. demonstrated the DNA methylation pattern to be similar in chronic phase PV, ET and PMF, and differentially methylated genes were mostly enriched in the NF-κB pathway.17 They also noted that in MPN patients who transform to AML, the number of differentially methylated regions increased significantly and the aberrant genes were involved in the 'interferon pathway' or were represented by genes already reported in de novo AML. Collectively, these efforts suggest underlying epigenome differences between the MPN subtypes with potential clinical impact, and provide motivation for the use of hypomethylating and other novel agents targeting the epigenome in the MPNs.
2. CML stem cells and efforts to target them
The currently licensed TKIs are remarkably effective in killing proliferating mature CML cells, but it is now clear that CML stem cells are probably not dependent on BCR-ABL1 for survival, and so alternative strategies targeting pathways that regulate the survival and maintenance of CML stem cells are required. Candidate pathways that appear to be activated by BCR-ABL1 include the JAK-STAT, mTOR, PI3K/AKT and autophagy signaling pathways (Figure 1). Additional areas of interest include the newly described Abelson helper integration site 1 (AHI-1), an adapter protein which interacts with BCR-ABL1 and JAK2 to mediate the response of CML cells to imatinib, and the mechanisms by which CML stem cells interact with their microenvironment.18 Several groups have recently demonstrated the successful targeting of both BCR-ABL-1 and JAK2 in the CML stem cells in in vitro models of CML stem cells procured from imatinib-resistant patients.19 The notion of combining ABL-1 TKIs and JAK inhibitors, however, remains uncertain at this time.20
Other candidate pharmacological interventions of interest include innovative methods in targeting the bone marrow microenvironment which can function as a protective factor against TKI-induced apoptosis of CML stem cells and several diverse strategies, including the combination of TKIs with other candidate inhibitors which target diverse signaling pathways, including WNT/β-catenin, Hedgehog, TGF-β/FoxO3a/BCL6 and JAK2/PP2A. When considering bone marrow microenvironment, it is particularly important to consider the marrow niche, a physico-chemical space that not only protects the stem cells, but also appears to play a major role in the trafficking and retention of these cells via the chemokine receptor CXCR4 and its ligand CXCL12.21,22
3. What is the clinical impact of the JAK inhibitors in patients with myeloproliferative neoplasms?
The treatment algorithm for most patients with MF, but not the other subtypes of MPN, has changed dramatically following the recent introduction of the JAK inhibitors into clinical practice.23,24 Long-term follow-up data of the 2 randomized phase III COMFORT trials with the JAK1/JAK2 inhibitor ruxolitinib confirm the efficacy of the drug, irrespective of the presence or absence of the JAK2V617F mutation, in ameliorating symptoms, reducing splenomegaly and according a modest survival benefit. The overall safety of the drug has also been confirmed, with hematologic toxicity, primarily anemia and thrombocytopenia, representing the most common side-effects. Anemia is an on-target side effect of JAK2 inhibitors, with the exception of momelotinib (formerly CYT387; Gilead), which well may have a unique hematologic profile.25 About half of the transfusion-dependent subjects with MF enrolled in a phase I/II trial of CYT387, with a follow up at 2.5 years, obtained durable transfusion independence, and a general decrement of the percentage of all subjects requiring RBC transfusions as compared to baseline was also observed. The reasons for this intriguing unique characteristic of CYT387 compared with the other JAK inhibitors are unclear. All of the currently reported clinical data on the JAK2 inhibitors in patients with MF show considerable efficacy in reducing splenomegaly and ameliorating the constitutional symptom burden. It is generally considered that the abnormally increased inflammatory cytokines are a target of JAK2 inhibitors, but the precise details of their clinical impact still have to be clarified.
Additionally, a topical challenge is to address the impact of the JAK inhibitors on the natural history of MF, and indeed other MPNs. Currently there is no firm consensus on the impact of these drugs on the allelic burden of JAK2V617F, or on the extent of bone marrow fibrosis. Vannucchi et al. reported that patients receiving ruxolitinib had an overall approximately 8% reduction in JAK2V617F allele burden at week 72 (range −51% to 15%); however, a subset of patients (22%) presented allele burden reduction greater than 20% that correlated with achieving the primary end point of more than 35% reduction in spleen size, suggesting that some patients might be more sensitive to JAK2 inhibitor treatment.26 Kvasnicka et al. presented preliminary evidence suggesting a reduction of bone marrow fibrosis in a cohort from an earlier phase II study with ruxolitinib.27
The combination of JAK inhibitors with other molecules targeting different pathways is also being addressed at the pre-clinical and clinical levels. Candidate drugs include histone deacetylases, inhibitors of HSP90, the PI3K/mTOR pathway and of hedgehog signaling. Their activity as monotherapy and in combination with JAK inhibitors is supported by analysis both in vitro and in mouse models, and phase I/II trials combining ruxolitinib with panobinostat (an HDAC inhibitor), BKM120 (a PI3K inhibitor), LDE225 (a hedgehog inhibitor), or decitabine (a DNA methyltransferase inhibitor) are currently underway. Efforts are also being directed to addressing issues related to acquired resistance to JAK inhibitors.28
4. What is the prognostic impact of the BCR-ABL1 transcripts levels at three months?
Much interest has focused on the value of BCR-ABL1 transcript levels measured at three or six months following the initiation of TKIs as first-line and subsequent therapies.29 Patients with BCR-ABL1 transcript levels of less than 10% at three months appear to have significantly increased rates of CCyR and CMR, and longer progression-free and overall survival compared to patients with higher transcript levels (>10% on the International Scale (IS)). Several groups have now independently validated this "Early Molecular Response (EMR)" milestone.30 The 2013 European LeukemiaNet (ELN) CML guidelines, which are not dissimilar to the 2013 NCCN guidelines, recommend molecular response to be assessed at three, six, and 12 months. BCR-ABL1 transcript levels of less than 10% at three months, less than 1% at six months, and less than 0.1% from 12 months onward represent an optimal response.31
5. Can TKI therapy be discontinued safely in patients with CML who have achieved a complete molecular response?
It is generally accepted that TKI therapy should be continued indefinitely in patients with CML who are responding optimally and tolerating the treatment well. The unresolved challenge, therefore, is really how long to continue treatment, which is of additional interest given that most patients have persistent CML stem cells, and the ability of TKIs to 'cure' remains uncertain. For the patient who has achieved a CCyR, stopping the drug usually leads to recurrence of BCR-ABL1-positivity and eventually, if left untreated, cytogenetic relapse in a substantial proportion. The French STIM (Stop Imatinib), the European Stop Kinase Inhibitor (EURO-SKI) trials and the Australian CML8 study (TWISTER) are probably the best efforts currently addressing this challenge.32,33 In the 36-month update of the STIM study, it was observed that the overall probability of remaining in complete molecular response (CMR, equivalent to a >4-log reduction in BCR-ABL1 transcript levels) at 36 months after have stopped taking imatinib was 39% (95%CI: 29–48). Most of the patients who experienced molecular relapse did so within six months of discontinuing imatinib, and importantly, responded promptly to the reintroduction of imatinib, suggesting that discontinuation did not result in an acquired resistance. The efforts so far have identified patients with a low Sokal risk score, male sex, and longer duration of imatinib treatment as potential prognostic factors for the maintenance of CMR after discontinuing imatinib. Currently, it is probably best to discontinue the TKI therapy only within the framework of a clinical trial.
For patients with CML in chronic phase, there are now five TKIs in the clinics: imatinib, nilotinib, dasatinib, bosutinib and ponatinib. The first three are licensed for first-line use, in addition to other drugs such as interferon and omecetaxine. Figure 2 depicts a potential current treatment algorithm for the newly diagnosed patient in chronic CML who has failed first-line imatinib therapy (JM Goldman and TI Mughal, personal communication, 2013). Both of the 2nd-generation TKIs, dasatinib and nilotinib have, so far, fared considerably better than imatinib in randomized studies of first-line treatment for patients in terms of achieving a higher rate of CCyR and MMR, but not in terms of progression-free survival or overall survival.34 One of the current challenges, therefore, is to establish whether the next generation TKIs might provide an overall survival which is significantly better than 85% at ten years. This will be a daunting task of recruiting large numbers of patients into large randomized prospective trials that would require lengthy follow up at a considerable cost. Moreover, unlike many of the current TKI trials, it will be useful if the future trials could have homogenous definitions of the different end points and events.
There is persuasive evidence that imatinib 600 mg daily is tolerated in more than 80% of CML patients and results in superior cytogenetic and molecular responses at 12 and 24 months compared to the conventional 400 mg daily dose.35 Regardless of the dose of imatinib, the current safety analysis of imatinib is quite impressive, with very few potentially serious long-term effects, including those concerning quality-of-life issues. Side-effects include nausea, headache, rashes, infraorbital edema, bone pains, and, sometimes, more generalized fluid retention. Efforts are ongoing to develop suitable strategies which should facilitate the safe discontinuation of therapy for patients who achieve a CMR.36 This issue is clearly important from a cost perspective also.37 Each of the newer agents may be associated with the development of adverse events, some of which can be serious and include peripheral arterial occlusion and arterial thrombosis.
In sharp contrast with the deep molecular response and the durable long-term remission of CML with TKI, the impact of JAK2 inhibitors in patients with MF is, so far, limited to the control of splenomegaly and symptomatic improvement, with scarce current evidence in support of deeper effects on disease pathophysiology. Yet, these agents have a profound, unforeseen impact on the quality-of-life of patients with MF, and the overall improvement also provides survival benefit. These agents are relatively safe, and the hematologic toxicity reflects the essential non-redundant role of JAK2 signaling in normal hematopoiesis. Nonetheless, the follow-up period is relatively short and there are some concerns with regards to optimal dose. Acquired clinical resistance to JAK2 inhibitor therapy is being observed, possibly due to novel mutations, and might represent a challenge for the future therapies. Combining JAK inhibitors with other targeted drugs, including immunomodulators, epigenetic agents and telomerase inhibitors, are now being pursued, in tandem with efforts to unravel the underlying molecular complexities.38
the participants of the 7th post-ASH Workshop on CML and MPN were: Chairs: J.M Goldman, T.I Mughal & A. Tefferi; Plenary speaker: W. Vainchenker; Faculty: O. Abdel-Wahab, T. Barbui, G. Barosi, O. Bernard, J. Crispino, G. Finazzi, C. Gambacorti-Passerini, J. Gotlib, P. Guglielmelli, R. Hehlmann, O. Hantschel, C. Jamieson, J-J. Kiladjian, G. Martinelli, M. Mauro, D. Perrotti, L. Pieri, G. Saglio, T. Skorski, S. Soverini, J. Thiele, R.A. Van Etten, A.M. Vannucchi. This workshop was made possible by unrestricted educational grants from Incyte Corporation, Bristol-Myers Squibb and YM Bioscience. Special thanks to Dr Alpa Parmar and the Alpine Oncology Foundation team for their help with the workshop logistics.
↵* Deceased 24th December 2013
Tariq Mughal is a Clinical Professor at Tufts Medical Center, Boston, USA, and Attending Physician in Hematology and Oncology in Denver, Colorado, USA. His principal interests are in hematologic malignancies, in particular chronic myeloproliferative neoplasms. Alessandro Vannucchi is an Associate Professor of Hematology at the University of Florence, Italy. His principal interest is myeloproliferative neoplasms. Simona Soverini is a senior researcher at the University of Bologna, Bologna, Italy. Her principal interest is genomic and genetic research in myeloid malignancies. Alexandra Bazeos is a research fellow at the Hammersmith Hospital and Imperial College London. Her principal interest at present is epigenetics in chronic myeloid leukemia. Raoul Tibes is an Assistant Professor of Medicine at the Mayo Clinic in Scottsdale, Arizona, USA. His principal interest is myeloid malignancies. Giuseppe Saglio is a Professor of Hematology at the University of Turin, Italy. His principal interest is hematologic malignancies, in particular chronic myeloproliferative neoplasms. Omar Abdel-Wahab is an Associate Professor of Medicine at the Memorial Sloane-Kettering Cancer Center in New York, USA. His principal interest is the basic science and clinical research in myeloid and lymphoid malignancies. Animesh Pardanani is an Associate Professor of Medicine at the Mayo Clinic in Rochester, Minnesota, USA. His principal interest is the research and treatment of myeloid malignancies. Rudiger Hehlmann is Chair of European Leukemia-Net and Professor of Hematology at the Universität Heidelberg, Mannheim, Germany. His principal interest is chronic myeloproliferative neoplasms. Tiziano Barbui is a Professor of Hematology and Director of Research at the Papa Giovanni XXVVVI Hospital and Research Center, Bergamo, Italy. His principal interest is myeloproliferative neoplasms. Richard Van Etten is the Chief of the Hematology/Oncology Division and Professor of Medicine at the University of California Irvine, USA. His principal interest is in the research and treatment of myeloid and lymphoid malignancies. Ayalew Tefferi is the Chief of Hematology at the Mayo Clinic in Rochester, Minnesota, USA. His principal interest is the research and treatment of myeloid malignancies. John Goldman was an Emeritus Professor of Hematology at the Hammersmith Hospital/Imperial College London, London, UK. His principal interest was in chronic myeloid leukemia.
Financial and other disclosures provided by the author using the ICMJE (www.icmje.org) Uniform Format for Disclosure of Competing Interests are available with the full text of this paper at www.haematologica.org.
- Copyright© Ferrata Storti Foundation


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Fact-checking Spike Lee's BlacKkKlansman
By Manuela Tobias on Thursday, August 30th, 2018 at 6:42 p.m.
Editor's note: Have you ever wondered if the movie you just saw — that claimed to be based on a real story or historical events — was really accurate? So have we. Everyone from Cannes to Twitter seems to be talking about BlacKkKlansman, so we wanted to help you sort out the facts from the dramatic liberties. (We've also fact-checked The Post, Darkest Hour and Dunkirk.) Warning, major spoilers and plot points ahead!)
"Dis joint is based on some fo' real, fo' real s---," the title card to BlacKkKlansman reads.
BlacKkKlansman, Spike Lee's latest film, tells the tale of a black detective in the Colorado Springs Police Department who infiltrates the Ku Klux Klan between 1978 and 1979. The detective, Ron Stallworth, strikes up a phone friendship with the local chapter of the Klan and with David Duke himself to discover and thwart cross burnings and a bombing.
The movie is laced with expletives and explosives. But how much of it is based on real events?
It's adapted from Stallworth's memoir, which he published in 2014. The decorated 32-year law enforcement veteran wrote it using the investigation casebook he was ordered to destroy (but didn't) by his sergeant in 1979.
To fact-check the movie, we relied on his account to verify the conversations between officers and the Klansmen as well as newspaper coverage at the time.
Here's what's real and what's not.
In the movie: Flip's Jewish identity almost compromised the operation.
In reality: Stallworth's sidekick was not Jewish.
The movie kicks into gear when Ron, played by John David Washington, calls the number on a classified ad placed by the Ku Klux Klan in the Colorado Springs Gazette-Telegraph. He leaves a detailed message with his real name. Before the length of the message lapses, the phone rings. The Klan calls back.
In real life, time passed a little slower. Stallworth didn't call, but expressed his interest to the Klan in a letter addressed to the post office box listed in a classified ad, according to his memoir. He also mistakenly gave away his real name in the note.
We found a couple of classified Ku Klux Klan ads in the Gazette-Tribune tucked between ads for dating services from that time period. One from Nov. 15, 1978, read, "Ku Klux Klan is forming. For information P.O. Box 4771, Colorado Springs, CO 80930."
The ads began running in June 1978, according to reporting in the Colorado Springs Sun by Nancy Johnson. The chapter leader, remaining anonymous, told Johnson the response had been "super fantastic," although many of the phone calls had come from black people who were worried about the Klan's resurgence.
"They tried to disguise their accent, but even after 200 years of education by the white race, they can't do it," he said, according to Johnson's reporting.
Apparently, their radar was not that sharp.
Stallworth got a call back within two weeks, in November 1978. Kenneth O'Dell, the local chapter leader and a soldier stationed at Fort Carson, proposed a meeting. Stallworth described what he would look like with his colleague, Chuck, in mind: "I'm about five foot nine, 180 pounds. I have dark hair and a beard," Stallworth said. His whiteness was implied.
Chuck worked in the narcotics division. Stallworth has declined to disclose his name in both his memoir and interviews with the media.
Chuck's availability was limited "because of both his narcotic workload and department politics," Stallworth writes. So the bulk of the investigation took place over the phone. He ended up being joined by another officer when the Klan insisted members bring recruits.
In the movie, however, Chuck is called Flip, played by Adam Driver, and has a much bigger role.
Here's where the movie and reality begin to diverge. In the movie, Flip is Jewish. The real Chuck was not. Flip's identity creates significant tension as he stands in for Stallworth during meetings with the Klan.
Felix, the second-in-command in the local Klan chapter in the movie, is wary of Flip from the moment they meet. He first accuses him of being a cop, and repeatedly presses him to prove he is not Jewish.
In one particularly tense scene, Felix locks Flip in a den with him in his basement. He tells Flip he has to take a lie detector test to make sure he is not Jewish. At one point, he whips out his handgun and threatens to examine Flip's penis to see if he is "circumstanced."
Ron comes to the rescue, hearing the threat over the microphone in Flip's shirt. He hurls a rock at the window, provoking Felix's wife's screams. Felix rushes to her rescue; Flip follows. They chase after Ron's car, which Felix shoots at. Flip blocks the gun and takes it himself, shooting aimlessly at the road as Ron drives away.
None of that happened.
Stallworth said no guns were ever pointed at him during this investigation, and the Klan never cast doubts on his or his partner's identities.
And no, Felix did not show up at Stallworth's doorstep to discover a black man as he did in the movie.
In the movie: Stallworth reveals his identity to Duke in a phone call.
In reality: The conversation never took place.
O'Dell, the chapter leader, did once pick up on the difference in Stallworth and Chuck's voices.
"The minute he heard my voice on the phone, he said, 'What's wrong with your voice?' So I coughed, and then I said, 'I have a sinus infection.' He said, 'Oh, I get those all the time. Here's what you need to do.' Then he proceeded to describe a remedy for me. That was the only time that my voice was challenged as being different from Chuck's," Stallworth said in a recent interview.
But Stallworth does not recount being too careful in his telephone exchanges. After Duke told him he could tell a person was black by the way he pronounces "are" ("are-uh"), as he did in the movie, Stallworth recalls in his memoir he would always find a way to incorporate that pronunciation of the word into the conversation.
That leads us to the poignant conversation at the end of the movie, when Stallworth reveals to Duke that he's been duped by a black detective. The real Stallworth talked with Duke following Duke's visit, but Stallworth never revealed his identity. He cut off communication with the Klan and had his phone line changed when his superiors decide to end the investigation. His story only went public in 2006.
In an Aug. 7, 2018, radio podcast, Duke complained the movie portrayed him as a hateful buffoon. He did not, however, cast doubt on the book, which he said portrayed him as a "genius."
"The film even changes the facts in Ron Stallworth's book, Black Klansman, to demonize me," Duke said. "They brag about how this guy conned me. Somebody calls me on the phone, I tend to trust people, I talk to people I've got nothing to hide. I say the same thing to everybody."
"Spike made him look kind of stupid," Stallworth told Lester Holt in an interview. "But he was stupid in how this whole thing transpired 40 years ago."
In the movie: Stallworth was Duke's bodyguard during his Colorado Springs visit.
In reality: He was.
Duke's visit to Colorado Springs was decked out in the movie. Two fancy black cars and a gang of motorcycles transport Duke to a church then a lodge for an ornate baptism of new Klansmen.
In real life, the baptism happened in one of the member's apartment buildings. Duke did sprinkle holy water on them. Of the 12 new members, three were policemen: one was Chuck, another his partner, Jim, and a third officer from Denver.
They then watched the film Birth of a Nation, as they did in the movie.
The luncheon was the following day, but at a local steakhouse — not a fancy lodge. The real Stallworth was also summoned to provide security for Duke.
"There were no more than eight local Klansman at the luncheon," a Jan. 11, 1979, article in the Gazzette-Telegraph reads. "The small group also included two plainclothes policemen from a Denver suburb who were assigned to provide security for Duke and Fred Wilkins, a resident of the Denver suburb and head of the Ku Klux Klan in Colorado. A Colorado Springs detective sergeant was also assigned to Duke and Wilkins, and two Colorado Springs patrol cars were stationed in the parking lot of the restaurant."
That detective was the real Stallworth, according to his memoir.
In the movie, chants of "America first" hark back a little too conspicuously to the Trump era. Turns out they're a reflection of history, according to the Sun reporter, Nancy Johnson.
"I thought for sure Spike Lee had just thrown that in to make the connection to present times. And I think a lot of people thought so, too," Johnson said. "But there it is in my story!"
"The KKK stands for five principles," the June 30, 1978, Sun article reads. "The organization supports the white race, 'America first,' the United states Constitution, free enterprise and Christianity."
In the movie, Stallworth requests a photograph with Duke. He waits until Flip counts to three and wraps his arm around Duke's shoulder, to which Duke reacts violently, and Stallworth warns him that assaulting a police officer could land him in prison.
According to Stallworth's biography, that really happened. But he lost the Polaroid.
In the movie: Three Klansmen die in an explosion and one is arrested.
In reality: No C4 was stolen or set off, and no arrests were made.
The cheeky photograph is the highlight of the luncheon in Stallworth's memoir. In the movie, three deaths and an arrest are the dramatic high point.
Connie, Felix's wife, leaves the lunch abruptly with explosives — the same explosives that mysteriously went missing from the local army base. Her plan is to set a bomb off at a Colorado College Black Student Union gathering. She fails, however, because cops swarm the area. So she reverts to plan B: placing the bomb outside the house where Patrice, the BSU president and Ron's girlfriend, lives.
She gets scared as Patrice approaches the house and places the explosives in her car instead. Three Klansmen come to pick her up, believing the C4 is in the mailbox. But it's in the car, which they are idling beside. All three blow up as they flip the switch. After assaulting Ron, in spite of his yells that he is undercover, the police eventually arrest Connie.
None of that happened. No explosives went off, and no arrests were made during the investigation. (The racist cop, based on a real police officer in the Colorado Springs Police Department, was not arrested, either.)
There were explosives in real life, however. The Klansmen discussed bombing two gay bars during Stallworth's investigation and in May 1982, the Colorado Springs Police Department made 10 arrests in relation to a ring that was manufacturing bombs and selling explosives. Four of them had ties to the Ku Klux Klan.
Patrice's character isn't real, either. In the movie, Stallworth starts a romance with Patrice, whom he meets while being inducted into the investigations unit. In reality, Stallworth started dating his future wife just before his investigative work began..
The Colorado College Black Student Union did participate in protests of the Klan, but the main opposition came from the International Committee Against Racism, a branch of the Progressive Labor Party. Stallworth infiltrated the PLP alongside the KKK, cozying up to organizers and showing up at meetings so he could alert police to marches and potential violence.
In the movie: The Klan burns one cross.
In reality: They denied responsibility.
Stallworth acknowledges the less exciting conclusion of his investigation in his book.
"I have often been asked, 'What did you really accomplish over the course of this investigation without arresting any Klan members or seizing any illegal contraband?'
"My answer is always in this fashion: 'As a result of our combined effort, no parent of a black or other minority child, or any child for that matter, had to explain why an eighteen-foot cross was seen burning at this or that location – especially those individuals from the South who, perhaps as children, had experienced the terrorist act of a Klan cross burning.' "
Stallworth's investigation prevented three cross burnings, he said in an interview.
In the movie, two North American Aerospace Defense Command officers form part of the Ku Klux Klan. That checks out with Stallworth's memoir. The officers reportedly had top-security-clearance. NORAD discovered their membership in the Klan through Stallworth's investigation, as he acquired a list of all chapter members. He was then told they "would be transferred by the end of the day to the 'North Pole,' the farthest northern military installation in the U.S. command," Stallworth writes. Stallworth, however, never learned their identities.
We were unable to verify that. But the two Klansmen in real life, O'Dell and Josef Stewart, were Army sergeants at Fort Carson. Both were issued leave in November 1978 following the Colorado Spring Sun's reporting on their military links.
Stallworth's story ends in the movie with a cross burning. A large group of cloaked Klansmen set a towering cross aflame in the middle of a field.
Something similar happened in real life. Stallworth concluded his investigation at the behest of his bosses on March 30, 1979, when the Klansmen insisted that he become their new leader (as in the movie).
That night, five men "dressed in white" lit a cross on fire outside a local nightclub, where a fundraiser for a black teenager who was convicted for murder was taking place, according to an April 1, 1979, Gazette-Telegraph report.
The Klan denied responsibility. O'Dell told the reporter only three members of the Colorado Springs chapter own the traditional white Klan robes, so it couldn't have been them.
Lee ends the film with a montage from Charlottesville, Va.. The footage shows the white nationalists' march on the University of Virginia campus and the street protest that resulted in the death of Heather Heyer. That really happened.

subset: commoncrawl


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Most newsletter subscription boxes are missing a valuable reason that encourages people to opt in to your list. Beacon gives you a quick way of offering your readers an incentive that they can't ignore. Create the book, offer the incentive and watch your conversion rates increase.
Note: requires a free account available from www.beacon.by
Note: we do not currently support WordPress Multisite or the Thrive Content Builder
eBook Creation Features
- Include existing WordPress articles
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- Share via social media
- Publish in HTML5 or PDF
- Embed directly in WordPress
- Responsive Web Design
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- Ottimizzazione per i motori di ricerca (SEO)
- In book content analytics
Need help?
Checkout out our knowledge base:
Screenshot (schermate di esempio)
This section describes how to install the plugin and get it working.
- Select the 'Plugins' option from the sidebar in your WordPress Dashboard
- Click the 'Add New' Button at the top of the plugins page
- Type 'Beacon eBooks' into the search field
- Click 'Install' in the 'Beacon Plugin' box
Crediti e riconoscimenti
"Beacon Marketing eBooks" è un software open source. Le persone che hanno contribuito allo sviluppo di questo plugin sono indicate di seguito.
Traduci "Beacon Marketing eBooks" nella tua lingua.
Ti interessa lo sviluppo?
Esplora il Codice segui il Repository SVN iscriviti al Log delle Modifiche. Puoi farlo tramite RSS con un lettore di feed.
Changelog (registro delle modifiche)
- First release!
- Search function for create ebook now copes better with very large sets of posts
- Adds icons and header images for plugin directory
- Embed iframe clears surrounding content to prevent possible overlaps
- Updates embed to allow for scrolling within iframe
- Fixes conflict with some php installations when SELF is used rather than self
- Updates for compatibility with WordPress 4.5
- Manual connect / disconnect feature
- Add filter by tag and export Featured Image
- Button links based on admin_url and typo fix
- Includes note about not supporting multisite
- Updates Youtube video on plugin homepage
- Include pages as well as posts
- Low memory mode depending on number of posts and available RAM
- Small bug fix that prevented a minority of users from Creating an eBook
- Adjust position of create button to prevent getting hidden in safari when there are a lot of plugin notices
- Bug fix: Filter by category not always working
- Safari specific bug fix: Removes fixed positioning on Create button
- Allows max posts to be set by $_REQUEST['show']
- Compatibility check with WordPress v4.6
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- Loads posts incrementally so plugin works on sites with limited memory or a large number of posts
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- Compatibility check with WordPress version 4.7
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- Display error on too many posts to process
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- Includes post title with post_content by default
- Small PHP7.2 compatibility fix


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There are many people in the world who are worried about many things. We see these persons on the news in a panic that we humans are destroying the planet and Global Warming is going to decimate the earth. We… Read More ›
A Universe from Nothing
How God Created The Universe: Science And The Bible In Symmetry
The idea that the universe exists as a product of natural events, is unprovable by any scientific evidence. In fact, when we carefully study what took place during the first zeptosecond, or a trillionth of a billionth of a second… Read More ›
The Science Of Cosmology And The Bible
In 1929, Edwin Hubble discovered the stunning reality that the universe is expanding. By measuring the rate of this expansion it became possible to determine the age of the universe through calculating the moment when all of the galaxies were… Read More ›
It Is Inevitable That Science Will Acknowledge God As The Source Of The Universe
Every year new preeminent scientists are added to the list of those who have examined the evidence of the universe and conclude that it was made by an intelligence. In 2016, American theoretical physicist, Michio Kaku, said that the universe bears… Read More ›
Ice Creme and the Universe
A young boy was tasting a new flavor of ice cream that contained some of the most amazing tasty bits of flavor he had ever enjoyed. "How did you make this," Johnny asked the vendor. An college physics student standing… Read More ›


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$84.99Care Instructions
The .86"x .60" Water pendant is a celebration of our flow inward and outward. This delicate & classic pendant is exquisitely designed to carry the Blessing Flower. Let it bloom for you, reminding you of the miracle that you are!
Pendants with a center element take an additional 2 business days for setting. Our Natural diamonds are 2mm-2.5mm and arrive with a certificate of authenticity. Please allow 8 business days for the crafting of Solid gold orders and 10 business days for solid gold orders with a center element.
Following these simple instructions will insure that your Blessing Flower will continue to bloom for many years:
If any thing happens to it or if you have any questions, please contact us at: firstname.lastname@example.com


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Deluxe room with private patio & hot tub
The Deluxe Double Room is a popular spacious ground floor beachside option with comfy seating areas and an open sky private terrace with summer loungers and an outdoor hot tub, just a few steps away from the white sand of Ornos beach. The Deluxe rooms with private patio feature a generous secluded summer living outdoor space featuring an open sky hot tub. Relaxation is well complemented with in-room contemporary blue-lit waterfall showers. Relax with friends or lovers at the private outdoor hot tub just steps away from the beach.
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Thinking of changing up a room in your home? Consider going for a backsplash and tile choice that compliment each other. Offered at Ramar homes are these gorgeous options in grey. As mentioned on Houzz, "grey is a terrific color that can offer a soothing, cooling presence for a room. It's a neutral color so it works well with many other colors. It's a good choice for both a primary design color and for accent pieces.
"What you need to know about decorating with grey is that it takes a little bit of playing around to get the hang of how to use this color properly in your home. Sit down and think about the mood that you want to create. Then find the right combination of colors and textures to make grey work to create that perfect mood!" At Ramar Homes we're always ready to help you create a living space you'll love!


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Windows 10 Password Hacking (Even with Anniversary Update) NOTE: The content of this tutorial is for INFORMATIONAL PURPOSES ONLY I do not condone any unethical activity Step 1 – Get a USB stick (4GB fine) Step 2 – Download Kali Live DVD – direct download … Read More
reinstall windows 7 with no activation
You love windows 7, I love windows 7, we all do. So to help you hold on as long as possible, here's a way to save your activation for when you reinstall.
Runas Elevated Command Promt From Anywhere in Windows 7
The Intro How often have you had to deal with the headache of manually cd C:/Program\Files your way around in windows 7? I love windows, and I use it for my everyday, but if there's anything windows lacks, it's a decent command prompt. Look at … Read More


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Support Portal
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from contacting Support for issues related to email. We recommend temporarily :
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Copyright © 2002-2019 BeyondTrust Corporation. Redistribution Prohibited. All Rights Reserved.
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Dumpster Rental in Burns CO
Rent a Dumpster in Burns Now!
Quick 1-minute quote in Burns
Dumpster rental specialists are standing by to give you a quick, no-hassle quote. Let us know what dumpster size you are looking for, when you need it, and what zip code your roll-off is going to.
We are always available to help
Simply give us a call and we will answer any questions you may have about the Burns dumpster rental procedure, allowed materials, size you may need, etc.
Next-Day delivery of your dumpster
Our roll off containers can usually be delivered in Burns the day after you place your order. Make sure to call us early to ensure timely delivery.
Get a Quote! 888-880-3407
What Kinds of Debris Can I Put Into a Dumpster?
You can put most sorts of debris into a in Burns. There are, however, some exclusions. For instance, you cannot put chemicals into a dumpster. That includes motor oil, paints, solvents, automotive fluids, pesticides, and cleaning agents. Electronics and batteries are also prohibited. If something poses an environmental risk, you probably cannot set it in a dumpster. Get in touch with your rental company if you're uncertain.
That makes most kinds of debris you could set in the dumpster, include drywall, concrete, lumber, and yard waste. Just about any type of debris left from a construction job can go in the dumpster.
Certain types of acceptable debris, however, may require additional fees. In case you plan to throw away used tires, mattresses, or appliances, you should request the rental company whether you have to pay an additional fee. Adding these to your dumpster may cost anywhere from $25 to $100, determined by the item.
Terms to be aware of when renting a dumpster in Burns
When you rent a dumpster in Burns, you're dealing with professionals who use terms associated with the construction industry and dumpsters each day. Because you likely don't use these terms every single day, here's a bit of the lingo to get you acclimated. This can actually allow you to cope with business workers who may get impatient should you not realize what they're explaining about their products.
"Container" and "roll off" are both satisfactory terms for the big metal box you want to rent. Professionals do not use the term "dumpster" as much as the other terms. Containers are usually rented in cubic yard sizes, but you do not have to include the "cubic" part. Simply say "yard" or "yarder." If, for example, you want to rent a 30-yard dumpster, you may say, "I'm interested in a 30-yard roll off" or "I Had like to rent a 30-yarder." Take advantage of these terms, and you're going to seem like a pro when you call.
Call Now! 888-880-3407
Dumpster rental guidelines
When you want to rent a dumpster in Burns to use at your house, it's a great idea to keep several guidelines in mind. First, determine the size dumpster that may work best for your job. Temporary dumpsters typically come in 10, 20, 30 and 40 yard sizes. Next, consider the placement of the dumpster on your own premises. Recommendations call for you to provide an area that's twice the width and height of the container. This will ensure proper height and space clearance.
The price you're quoted for the container includes a one time delivery and pickup fee, together with standard fees for disposal, fuel and tax. You need to also understand that you can simply fill the container to the top; no debris should be sticking out. As the homeowner, you need to also check with your local city or municipality to find out whether a permit is necessary to put the container on the street.
City regulations on in Burns
Most cities or municipalities do not have many regulations regarding in Burns as long as you keep the dumpster entirely on your own property during the rental period. In case you need to put your container on the street at all, you'll probably need to obtain a permit from the correct building permit office in your town.
Most businesses in Burns will take care of securing this permit for you if you rent from them. Be sure that in case you're planning to place the dumpster on the street, the business has made the proper arrangements. You should also ensure that you get the permit in a timely manner and at the correct cost. In the event you believed the dumpster company was getting a permit and they did not, you'll be the one who will need to pay the fine that's issued by the authorities.
Call Now! 888-880-3407
Common items to put in a roll off dumpster
When you rent a roll off dumpster, you'll be tempted to throw anything and everything indoors. Common items that folks typically dispose of in a dumpster comprise solid waste material and most routine household and building waste, along with tree limbs and landscaping debris. They can also be utilized for business and commercial cleanouts, house renovations, getting rid of trash when you are moving to a new dwelling, bigger landscaping jobs and much more.
A record of things you CAn't place in a roll off dumpster contains paints and solvents, automotive fluids, pesticides, chemicals, electronic equipment and batteries. Should you try and include these items, you will likely get an extra fee. Other items that will definitely incur an additional fee include tires, mattresses and appliances. Additional heavy substances are also not enabled; items that are too heavy may surpass government transportation regulations and be unsafe to haul.
Permanent vs Rolloff dumpsters
Whether or not you desire a permanent or roll off dumpster depends upon the kind of job and service you'll need. Permanent dumpster service is for ongoing demands that continue more than simply a few days. This includes things like day to day waste and recycling needs. Temporary service is simply what the name implies; a one-time demand for job-specific waste removal.
Temporary roll off dumpsters are delivered on a truck and are rolled off where they will be used. These are generally larger containers that could manage all the waste which is included with that particular job. Permanent dumpsters are generally smaller containers since they're emptied on a regular basis and so do not need to hold as much at one time.
If you request a long-lasting dumpster, some companies require at least a one-year service agreement for that dumpster. Rolloff dumpsters only need a rental fee for the time that you just maintain the dumpster on the job.
Call Now! 888-880-3407
Dumpster Rental Companies Near Burns
|Company Name
|Andante At Nine Mile Station
|(303) 751-1600
|Garbagio LLC
|(303) 274-1500
|Smart Carpet Cleaning
|(970) 674-3355
|iDenver Repairs
|(303) 630-9499
|Junk King Colorado Springs
|(719) 694-5250
|TwentyOne01 on Market
|(888) 884-7652
|Cornerstone Apartments
|(303) 333-1999
|Boulder Carpet Cleaning Masters
|(303) 459-2482
|A Simple Move
|(303) 368-0700
|Junk King Denver
|(720) 458-1398
Our Service Area
Zip Codes in Burns80426
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10 Yard
Great for small projects
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For moderate sized cleanouts
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All around good dumpster size
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40 Yard
For the largest projects
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*Dimensions & availability may vary by location. Call to confirm.
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We accept
All major credit cards accepted for dumpster rentals in Burns.


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Processes & Quality
Quality deliverable's based on best practices
As your preferred solutions provider, Infinite Staffing is committed to delivering exceptional, reliable results every time. That's why we've based our processes on industry best practices and standards, as well as the experience from more than a decade of successful onsite/offshore development.
We know that discovering your true business needs is just the first step in delivering a successful solution. Our project management methodology is built on a set of process areas that provide the structure necessary to deliver reliable, cost effective solutions that help your company succeed.
We understand the impact process adherence has on the quality of our deliverable's. When Infinite Staffing undertakes your project, our project managers and developers come armed with the tools and framework necessary to deliver the best solution for your business needs.
Infinite's process areas
- Project planning developing, estimating and planning projects
- Requirements & design requirements elicitation, review and traceability as well as architectural design, review and sign-off
- Project tracking & monitoring monitoring progress against plans and reviewing forecasts at milestones
- Test & configuration management planning and executing testing and maintaining configuration management
- Project closure & recap transitioning information to you at the end of the project as well as recording successes and opportunities for improvement
- Process assurance providing the greatest benefit to our clients by maintaining processes and ensuring they are followed
Contact us today to discover how we can put our knowledge and experience to work for you.
Excellence guaranteed
In today's high-stakes business environment, it's even more important that every project you implement succeeds. Quality assurance is the key to successful, profitable development.
At Infinite Staffing, quality assurance begins at the requirements stage and continues through the project life cycle. Because clear, concise requirements are critical to a successful outcome, we conduct a series of requirements gathering sessions. The business and technical requirements gathered during these sessions are reviewed by your business stakeholders to ensure that all requirements are captured and understood.
A technical architect is assigned to manage the technical solution, assuring that all deliverables adhere to the requirements, and that development standards and best practices are followed. Code reviews and unit testing are conducted to identify and resolve potential issues early in the development process.
Our dedicated QA team conducts independent testing to verify the final solution meets standards and fulfills your business and technical requirements. Finally, your stakeholders complete acceptance testing prior to the final release.
Testing that ensures business value
Project deliverable's are assessed three ways to ensure quality and correctness (shown by the 3 types of arrows in the diagram)
- Verification – deliverables meet standards
- Validation – deliverables continue to flow from one stage to the next
- Testing – deliverables are properly implemented
Every IT initiative represents an opportunity for your company to become more competitive and profitable. Infinite Staffing's attention to detail helps drive your project from acceptable to excellent.


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SFr. 20.24
Thick, Curly Hair
This Sulfate-free conditioning cleanser removes impurities without stripping hair of natural oils. Lightweight moisturizers soften and control frizz in one easy step. Leaves curls vibrantly bouncy.
No sulfates. No parabens. No phthalates. No paraffin. No gluten. No propylene glycol. No mineral oil. No synthetic fragrance. No PABA. No synthetic color. No DEA. No animal testing. Made in the USA.
Video Tutorial:
Deionized Water, Cocos Nucifera (Coconut)Oil*, Butyrospermum Parkii (Shea Butter)*, Magnifera Indica (Mango) Seed Butter*, Olea Europaea (Olive) Fruit Oil, Triticum Vulgare (Wheat) Germ Oil, Cetyl Esters, Kaolin Clay, Grapeseed Oil, Simmondsia Chinesis (Jojoba) Seed Oil, Behentrimonium Chloride (Conditioner), Hibiscus Sabdariffa Extract, Salix Alba (Willow) Bark Extract, Melia Azadirachta (Neem) Seed Oil, Cetyl Alcohol, Vegetable Protein, Hydroxyethyl Cellulose, Stearyl Alcohol, Aloe Barbadensis Leaf Juice, Tocopherol (Vitamin E), African Black Soap Extract, Sea Salt, Rosemary Extract, Caprylyl Glycol *Certified Organic Ingredient
SFr. 24.90
100% extra virgin coconut oil is a natural ingredient rich in antioxidant Vitamin E and...
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A multi-tasking oil, rich in essential fatty acids and antioxidant vitamins. Helps keeps hair and...
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Dry, Itchy Scalp Dandruff Eczema & Psoriasis Sulfate Free Made with natural and certified organic...


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25 Years!
Dear Family,
Twenty-five incredible years that we; Ed, Judy, our children, and you, have been serving the Lord together. Together we have ministered to people, the people of the world. You have so faithfully sent us, with your prayers, your faith, your tears, and your finances. We have seen lives changed for all of eternity and rejoice together. How fun it is going to be when we all get to heaven and meet each other face to face and worship our Lord, Jesus together!
We deeply and sincerely thank you. You are God's Champions.
We love you,
Ed, Judy, Briany, Brittany, and Brent


text:
As a former teacher, I know how important visual perception and visual processing skills are to growing minds. I value games that help strengthen and sharpen those skills as they are two that carry over into reading and math as a student attempts to make sense of print and various math problems. I love the company Thinkfun for the very reason that their games are not only fun and engaging, but they always also offer players the chance to work on these skills and more. I recently reviewed three of their games (2 from their newest lineup) and I am delighted to share them with all of you!
With the regular Rush Hour and Rush Hour Jr. being very popular and a bestseller for Thinkfun games, I am thrilled they came up with yet another version with the Rush Hour Shift… one that allows for two players! In this game, escaping before your opponent is the goal. Every move counts in this race to cross traffic. Players use visual strategy to either advance your own Hero Car or block your opponent. The potential moves are endless and the shifting Traffic Grid adds a whole new dimension to play. Talk about utilizing visual processing skills- the shift takes this game to an entirely new level…literally!
Where will your mind and eyes take you in your Thinkfun game?
*DISCLAIMER: Any opinions stated are strictly my own. I was sent the above item by Thinkfun Games to help facilitate my review. All photos used in this post are courtesy of Thinkfun Games.*


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Valentine's Day is right around the corner, which if you're single may mean you are more aware of this than many of your friends who actually have a significant other. But, even if you do celebrate February 14th as Singles Awareness Day, you can still show some love to a very important "person" in your life—your car.
Just think about how much you appreciate your car—it gets you to wherever you need to go, gives you some great entertainment, and keeps you cool, comfortable, and safe on your travels.
Here are a few suggestions on how to pamper your car this Valentine's Day.
- Make it feel beautiful. Give your car a good wash, inside and out. You can even let your car spend a day at the "spa" by getting a professional detailing.
- Fall in love again. Remember how excited you were when you first purchased your car. You probably couldn't wait to sign those papers and take it out for a long drive. Reignite that spark by heading out on a long road trip just so you can enjoy driving again.
- Clear up any contention. If your car has been giving you trouble in certain areas—any squeaks, stalls, funny sounds, or behaving strangely—take it in for a checkup and let a service professional give your car a good tune up.
Will you be taking care of your car this Valentine's Day?


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Baume et Mercier Riviera Ladies MOA06307
- Stock #: DG0588
- Brand: Baume et Mercier
- Series: Riviera
- Series: *Specials*
- Model: MOA06307
- Special: Great discount
- Retail Price: $8,000.00
- Special Price: $2,100.00
Condition: New
Gender: Ladies
Dial Color: Black with Diamonds
Case: Stainless Steel 27mm
Bracelet: 18k Yellow Gold and Stainless Steel
Bezel: 18k Yellow Gold with Diamonds
Crystal: Scratch Resistant Sapphire
Movement: Quartz
Water Resistant: 50 meters / 165 feet
Box: Yes
Papers: Yes
Certificate of Authenticity: Yes
Warranty: Yes
Additional Information:
Brand new Baume et Mercier Riviera woman's watch, Model # MOA06307.
Stainless steel 27mm case. Black colored dial with diamond hour markers. Hours, minutes, seconds and date. 18k yellow gold bezel with diamonds. Quartz movement. 18k yellow gold and stainless steel bracelet. Water resistant up to 50m / 165ft.
Also known as:
baum, baume and mercier, 06307, 6307, MOA-06307
Subject to Availability


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The world's first electric taxi for tropical cities has been launched.
The taxi called EVA has a fast-charging battery system which gives a range of up to 200km (124 miles) after a 15-minute recharge.
EVA also has a cooling system in the seats which suck the moisture and heat from the surface.
The project was built by TUM CREATE, a collaboration between Nanyang Technological University Singapore (NTU Singapore) and German Univeristy, Technische Universität München (TUM).
Professor Bertil Andersson from NTU said: "NTU is at the forefront of sustainability research and we had identified electro-mobility as one of the solutions necessary to tackle climate change.
"Our success in building an electric car for the tropics is a big step forward in realising our vision for a more sustainable future for everyone."
Professor Andersson said TUM CREATE's electric vehicle production globally is expected to rise rapidly over the next decade.
The taxi is also Singapore's first locally made car which was designed and built in the city state.


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For more information on how G J S Contractors could help with your tarmacadam and surfacing needs, get in touch today.
We make sure that every job is tailored to meet the requirements of each individual customer.
Enlist our commercial tarmacadam services.


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Ernie Krivda: Blues for Pekar
As ever, Krivda favors longever so longspiraling lines that weave in and out of a tune's scripted framework, flashing by turns the polished chrome of a standard's communal lyricism and the barreling weight of Krivda's own athletic insistence. His tone throughout is deep, wide, strong and full, commandeering the surge through an equally dense and enveloping field loosed by bassist Marion Hayden and drummer Renell Gonsalves, and captured to wonderful, old-school effect by engineer/producer Michael Seifert of Cleveland's Ante Up Audio.
Pianist Claude Black adds a bright, at times too springy piano to the affair (although his solo on the wide-awake "Darn That Dream" is spot-on), while trumpeters Sean Jones and Dominick Farinacci, both native Clevelanders and former Krivda pupils, each lend the sear of brass to a pair of tunes. Protocol on these numbers (Farinacci on the title track and "The End of a Love Affair"; Jones on Sonny Rollins' "Valse Hot" and Dexter Gordon's "Fried Bananas") is for sax and trumpet each to take a solo, and then come together down the home stretchFarinacci's punctuated lyricism and Jones' relaxed swing both proving easy partners to Krivda's roiling bop.
Not only do the album's five standards serve as fertile bop soloing ground for Krivda and his mates, they also allow the saxophonist some arranging fun. "Love Affair" charges out of the gate in a rollicking exuberance far removed from the ballad's common moody rendering. Likewise, "Darn That Dream" is alive with expectant thought, while "More Than You Know" moves from Krivda's comically swaying, drunken horn into music which is alert and buzzing (with love, no doubt).
Still, it's the two Krivda originals at the album's close that give the work a relevance beyond the joyful and inventive. "One for Willie" pays homage to legendary Cleveland arranger and saxophonist Willie Smith, and contains, at its heart, a wonderfully conversational solo from Hayden. "Blues for Pekar" closes the set, the brash, harmonized theme from Krivda and Farinacci leading into soloing bluesy and swinging enough to carry any cartoon Pekar down the street in a proud, if curmudgeonly lope. The jazz is straight-ahead, the scene is down-and-out, the joy is in the moment.
Track Listing: The End of a Love Affair; More Than You Know; Valse Hot; Darn That Dream; Fried Bananas; One for Willie; Blues for Pekar.
Personnel: Ernie Krivda: tenor saxophone; Claude Black: piano; Marion Hayden: bass; Renell Gonsalves: drums; Sean Jones: trumpet; Dominick Farinacci: trumpet, flugelhorn.
Title: Blues for Pekar | Year Released: 2011 | Record Label: Capri Records


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- Id like to meet Romeo cause he is level-headed and id like to see how he acts at parties and towards Juliet. But he's not a fighter as he seems but a protector he does whats right how he asks for permission to marry Juliet or Rosaline.
- Him and Juliet do not really have anything in common and Romeo said he would never love another girl besides Rosaline, Romeo does married Juliet in the end.
- Very close to the church,he is a father to most and is quiet religious.
- I enjoyed scene 5 because Juliet gets worked up over the marriage and Romeo follows through with it, and marries Juliet.
- Juliet was not gonna marrie anyone at the start of the book.
© 2020 Perry Anderson | STJ iBlogs | Internet Savvy? | Contact STJ School | Log in


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The image below is a simple example of Sample Letters Of Appeal Medical Billing that might inspire you in creating a spreadsheet or report for your business.
From our example, you can add some things you may need to complete your spreadsheet.
You can have this example by saving it to your computer, tablet pc or smartphone.
See also other examples from Sample Letters Of Appeal Medical Billing below. Hopefully you are helped by the examples we provide.


text: CUSTOMER INFORMATION for BOOKING PROGRAMS Please complete this form indicating the Program Type, Number of People, Day of Week and Time preferences. We will get back to you with our availability, and send you an invoice to confirm your booking. Programs are considered booked when they are pre-paid. Refunds are available, by request, 7 days in advance. Your Name (required) Your Email (required) Subject Select Program Type Kayak TourIntro to KayakWomen's KayakingGray BladersTandem Canoe Number of People 1-Private2-Private2-Tandem Canoe45678 Preferred Day(s) of Week MondayThursdayFridaySunday Preferred Time(s) of Day 11:00 am1:00 pm3:00 pm6:00 pm Additional Information This is Not Spam (required) 7 + 4 = This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply. Weather and Cancellations We reserve the right to make final decisions about holding classes when there is the potential for inclement weather. Safety is our number one concern, and we will cancel classes if it is extremely cold or windy or if there is potential for severe storms. That said, we can still enjoy paddling on days that are cool and drizzly, and we do hold classes in these conditions. If we cancel or significantly shorten a class due to weather, we can offer you another class date (based on availability) or a refund. If we feel the weather is adequate for class and you choose not to attend, we may not offer these options. Exceptions are made on a case-by-case basis.


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These are goodies from Ligonier Ministries celebrating Free Reformation Friday, in honor of the Reformation Day itself.
And additional kindle deals! More deals can be found here.
Ligonier Ministries (free)
Reformation Profile (video series by Stephen Nichols)
Luther and the Reformation (video series by R.C. Sproul)
Are We Together? A Protestant Analyzes Roman Catholicism (audiobook)
John Calvin: A Heart for Devotion, Doctrine, and Doxology
The Heroic Boldness of Martin Luther
The Expository Genius of John Calvin
$0.99 Books
Autopsy of a Deceased Church: 12 Ways to Keep Yours Alive (this is a great short book, you really should get it at such a good price. I'll be posting a review on it in 10 days)
$2.99 Books
God's Will: Finding Guidance for Everyday Decisions
The Enemy Within: Straight Talk About the Power and Defeat of Sin (a helpful book that breakdowns John Owen book on Indwelling Sin)
Too many choices for you to choose and not sure what to get? How about a Giftcard?


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One of St. Louis Magazine's summer 2018 editorial interns, Klein studies English with a concentration in writing at Wheaton College. She enjoys writing about culture, literature, and music.
Ashley Klein
Educators share their go-to reading lists for pre-K to sixth grade students
How many has your child read? Read more
Camp the comfy way in six Missouri state parks with lodging
Pitching a tent isn't for all of us. These parks offer all sorts of options for a weekend getaway in the woods. Read more
theCoderSchool to open St. Louis location for young coders-in-training
The Silicon Valley–based company has more than 20 schools across eight states. Read more
Six places with unique running trails
Different surfaces, distances, and scenery keep summer runs interesting. Read more
With new mural, artist Cbabi Bayoc helps Carr Square residents transform Murphy Park
"We're trying bring up the area around the playground," says Bayoc. "Right now it's kind of dark and shadowed." Read more
10 places with shaded trails to escape the summer heat
Dense woods, deep valleys, and cool rivers offset the intensity of sunny days. Read more
Stargazing events at the Arch bring otherworldly fun to St. Louis
Get to know the moon, stars, and planets with local educators. Read more
Children's book 'Incredible Cardinals' honors St. Louis baseball legends
A baseball historian invites families to reminisce over their favorite baseball memories together. Read more
The Grand Market returns for its second year with double the vendors
On June 10, the family-friendly festival will once again bring together St. Louis creators, food trucks, and more. Read more


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Two things have come together to contribute to these ramblings about Christmas. The first is an article in this month's BBC History Magazine which tells me that Christmas was abolished by Christians in England in the 1640s. In a speech on Christmas Day in Watford (Mayor Thornhill take note!), these words were, apparently spoken,
"I give you to understand that the very name of Christmas is idolatrous and profane, and so, verily, are the 12 days wherein the wicked make daily…. sacrifices to riot and sensuality".
Let's park that for a minute and turn to my second source of thoughts. The TODAY programme! There I learned this morning that a very high proportion of cancers would still be avoided if people didn't smoke, drink and eat too much.
These thoughts come together because at Christmas there is much eating, drinking (and in some places smoking. According to our television screens we cannot have Christmas unless we stuff the Turkey and then ourselves. Well know cooks (well Erica has heard of them) vie to tell you of their magnificent creations. Beware however the one that has pine scented sugar on the mince pies. Apparently it tastes OK but the box smells like toilet cleaner.
Now you might say that these matters have nothing to do with me. Well some of the consequences of over drinking and over eating do have to be picked up by any of us with a social conscience or an elected position.
We have to persuade taxpayers to cough up large amounts of money for:
- The health services with women in their mid 30s now dying from liver and kidney problems that would normally be found in 60 year old men because of binge drinking,. We pay to keep people in hospital after they have picked up a range of illnesses because of obesity. We pay to keep A and E units fully staffed to deal with a range of self inflicted and externally inflicted ills on Friday and Saturday nights.
- Police who we pay to keep large numbers of police in the streets until all hours as our front line in often pitched battles with drunken yobs.
- Our cleaning staff to go into those streets to clear up the litter, urine and vomit which infects them before most other people turn in to do a day's work.
Above all it's tragic that we are bringing up a generation of children who are likely to have life spans shorter than ours and we do nothing about it.
So what can be done? Abolish Christmas? No I love Christmas at least from about 20th to 26th December. Like all homes we have our traditions. Erica and I always keep some of our 6,000 Christmas Cards back to deliver on Christmas Eve. (Beware two nutters with reindeer antlers who will be seen in the Allerton Road area on 24th December). Our holiday is made special by the arrival of our Grand daughter and we might just spoil her a little. But why oh why does it drift on for days afterwards and months before? We must have a serious debate about consumerism and how Christmas distorts spending for many and impoverishes a small number of people for most of the year.
We must deal with alcohol and there are two ways. Firstly make the polluter pay. Push up the price of alcohol to make it more difficult to purchase large quantities. This applies to all vendors of alcohol. Much of the orgy of violence on our streets is fuelled by people who get tanked up on cheap supermarket booze before going out to get topped up in the club. Then use the money to pay for the policing and the clean ups.
Second take much more care of advertising which is still too common and still to redolent of glamour and hardness ( Famous Grouse adverts can be excluded from this – they are always marvelous.
We must deal with tobacco in the way thatAustraliadoes. There a law has been introduced which makes all packs plain and, again, takes the glamour out of the practice.
In schools and colleges there must be full engagement with young people about obesity, smoking and drinking. No-one wants to die in their mid 30s but when you're 15 you think you are going to live forever.
So it may appear to some of you that I come up with these warnings of doom like Marley's Ghost. I hope not. I hope that everyone spends the next 3 weeks preparing for and enjoying a sensible, moderate and affordable Christmas. I hope that like Mr. Scrooge you will learn the lessons of Christmas are far more important than what you do with a 'few of your earthly pounds'.
Above all if you had a few too many and are out onAllerton Roadon Christmas Eve and announce in a slurred voice, "We only do it for the Kids!" watch out for a strange man with antlers. An antler might end up in a place where antlers aren't supposed to go!


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D.I.Y. MAGIC by Anthony Alvarado
40 b&w illustrations, cover design by Lord Breaulove Swells Whimsy
First edition letterpress silver foil cover limited to 1000 copies, 176 pages, 5″ x 8″,
Lucky's just received an interesting literary spectacle in the form of a small book of 'new wave' magic.
Scattered throughout the many chapters are illuminating illustrations and artworks from a handfull of talented underground and established comic book artists.
Luke Ramsey, Jason McClean, Faryl Dalrymple, Ines Estrada and Ron Rege Jr. and just a few of the talents featured within the text.
From what i get from the book,Alvarado speaks of magic in a form thats really just practical living,poetry for life in the guise of supernatural spells.
As strange as this book seems on the outside,its also accessible to casual readers as well as hardcore fans of the occult.
Another one of a kind publication from our American friends Floating World Comics in Portland Oregon.
-Ben Jacques, vancouver artist and amateur dark mage.
heres a couple more write ups..
"Few books are as immediately useful as this delightful, inspirational tips 'n' tricks tome. I'm having a backyard betel nut party in five minutes and everyone's invited!" -Jay Babcock, editor of Arthur Magazine
"Anthony Alvarado has concocted a cookbook for vivid living: poetry that's lived rather than written.His "spells" are actually practical suggestions by which the reader may coax the extraordinary from the everyday—and from themselves." – Lord Breaulove Swells Whimsy, author of The Affected Provincial's Companion
— Lucky's


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Wildcat Five Panel BlackRegular price $44.99
or make 4 payments of $11.24 with More infoSave $-44.99
This hat won't give you the ability to throw a Wildcat but you will look stylin' in it, so win win right?
- 100% cotton twill
- 5 panel unstructured cap, with soft peak/li>
- Woven polyester Yuki logo label on front
- Woven polyester Yuki pip label on back
- Contrast yellow binding on inside seams
This product in produced in a social audited factory to ensure that all workers have been treated fairly.
We donate 1% of all sales (not just profits) to 1% For The Planet, as a self imposed environmental tax in order to offset our impact as a business. From this we choose what environmental grassroots level organisations to support.


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Project Halley Beauty
There is a long, blank wall in Halley Medical Aesthetics (Halley) that was the personal bugbear of the clinic's marketing communications manager, Khay, since it started operation. The problem wasn't structural but an aesthetic one. It was bare, devoid of any artwork or feature to reflect Halley and Dr. Terence Tan's philosophy to medical aesthetics.
"From the get-go, we were very clear that Halley's message to the public and potential patients is that beauty exists everywhere. Beauty lies in the objects we see everyday like a tree, a building, and in the person looking back at us in the mirror" says Khay. "We believe that beauty is and should be defined by each individual. We don't need the mass media to tell us what is beautiful. All we need is an experienced doctor with a keen sense of aesthetics to bring out the best in you." This is very much like artists who turn mundane, everyday objects like a driftwood into a piece of art or a florist who places individual blooms together to create a stunning flower display.
Dr. Terence Tan chatting with artist Miun at her "sixth sense" exhibition.
"That is why we don't use models, who are traditional representations of beauty, on our website, Facebook, Instagram, blog, and print ads to deliver a message. Therefore any artwork that goes on our wall has to reflect Halley's perspective," explains Khay.
When the Halley team visited local artist Miun's "Sixth Sense" exhibition in October 2014 done in collaboration with Leica Camera, Khay knew instantly that Miun was the artist who could fulfil the vision. That was when she commissioned Miun to create a mural to fill the blank wall in the clinic.
Project Halley Beauty
As an artist, Miun is known for her installations and work using flowers as her medium. She most recently participated in SingaPlural 2015, an anchor event for Singapore Design Week, where she married real and fake flowers to create new species of flowers in her display, "The Marriage". Khay had also seen several of Miun's murals like the one in The Panic Room, an uber cool barber shop in Geylang.
Explaining her vision
Perhaps being friends even before this working relationship started made it easy for Miun to understand Halley's philosophy. "When Miun told me her artistic vision for our mural, I was excited; she understood our positioning. But as with working with any artist, I won't be able to 'see' her actual vision until the work is complete. There is always some uncertainty as to what artistic track she would eventually choose.
"But that is why selecting an artist, like selecting a medical aesthetics doctor, is so important. You have to first like their artwork, then trust their sense of aesthetics, and let them execute and deliver your vision," says Khay.
After given the brief, Miun felt her strength and interest in flowers melded well with Halley's philosophy. Like flowers that will blossom over time, everyone who steps into the clinic can be transformed into unique, individual pieces of artwork.
And that was how Halley's mural by Miun came about. Within each frame that Miun painstakingly sprayed with different hues of gold is a flower, drawn directly on the wall with black markers. Some of the frames were new while some were pre-loved items from Hock Siong & Co., a furniture store that sells used quality furniture and eclectic kitchenware. No matter their condition, each was lovingly painted and enhanced under Miun's hand, "just like how we'd treat each and every patient in the clinic", quipped Khay.
Miun lays out all the newly bought frames the way she wants it on the wall.
Miun's workspace when painting the frames
The original frames are slowly making its transition.
Before and after: carved wooden panels from Hock Siong get a makeover by Miun
The final product
So if you are ever passing by River Valley Road before heading for dinner or drinks at Mohamad Sultan, please drop by and check out Miun's mural in the clinic.
Halley Medical Aesthetics
248 River Valley Road Singapore
Singapore 238302
Opening Hours
10:00 am - 9:00 pm
Tel: +65 6737 8233
For more information, please go to:
Facebook: www.facebook.com/halleymedicalaesthetics
Website: www.halley.com.sg


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W. Scott Thompson, M.D.
Dr. Scott Thompson joined Retina Group of Florida after serving as Chief of the Resident Service and Instructor in Ophthalmology at Bascom Palmer Eye Institute in Miami. During that time, he supervised ophthalmologists-in-training and maintained an extremely active retinal practice.
Dr. Thompson graduated with honors from Dartmouth College, where he majored in Molecular Genetics. While at Dartmouth, he was honored with the Xerox Young Researcher Award. He earned his Medical Degree with high honors from The Baylor College of Medicine in Houston, where he was elected to the Alpha Omega Alpha Medical Honor Society and earned the Award of Excellence in Clinical Neurology. He completed his internship at Baylor College of Medicine Affiliated Hospitals. Dr. Thompson came to Miami for his residency training at the Bascom Palmer Eye Institute, where he also completed his Fellowship in Vitreoretinal Surgery and Medical Retina (with Dr. Don Gass). He served on the Bascom Palmer Faculty, prior to joining Retina Group of Florida. Dr. Thompson is Board-Certified by the American Board of Ophthalmology.
Dr. Thompson has performed research on the diagnosis and treatment of retinal disease, which has been presented at the American Academy of Ophthalmology, American Uveitis Society, and American Society of Retinal Specialists. His research is published in numerous medical journals.
Dr. Thompson is a member of the American Academy of Ophthalmology, Florida Society of Ophthalmology, Miami Ophthalmological Society, Association for Research in Vision and Ophthalmology, and American Society of Retina Specialists. He has served as President of the Broward County Ophthalmology Society, where he remains a member.
Dateline Health Show 454: Eye Care and Retina Issues
Dr. W. Scott Thompson, M.D. from Retina Group of Florida discusses Retina Detachment
Hover your curser over the video and click the play button


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Oak Barn Beef
Gourmet Foods & Beverages
About Us
When a third grader from a rural community told me that eggs came from cows because they were next to the milk in the grocery store, I realized the huge opportunity I have to connect with consumers who want so badly to be connected with where their food comes from. So then, Oak Barn Beef was born.
To connect the producer-consumer gap and ''put a face to the farmer,'' I started selling my family's beef on a local and national level. I dedicate most of my marketing powers to Instagram, where I am able to share my family farm story and drive profits through this advocation.
Our cattle are Nebraska Raised & Dry Aged on our family farm. They are not given growth hormone implants or antibiotics, creating an "All Natural" title. We have also work with a small-town butcher to hand-cut and dry age the whole beef. If you're not familiar with the dry aging process, it is like giving a good cheese time to mature. The natural enzymes in the beef breaks down muscle tissue, which creates a WAY more tender and flavorful cut of beef.
Oak Barn Beef is striving everyday to improve how people view the beef industry by connecting producers and consumers while supplying a dang good dinner for you and your family. Oak Barn Beef is a cut above the rest.
Video Media
Rep/Contact Info
GROW Nebraska® Foundation Headquarters Marketing & Innovation Center
Younes Campus
421 W Talmadge Street Suite #1 | Kearney, NE 68845
308.962.6767 | firstname.lastname@example.com
Buy Nebraska Gift Store
Younes Campus
421 W Talmadge Street Suite #1 | Kearney, NE 68845
308.338.3520 | firstname.lastname@example.com
We are a nonprofit 501c3 providing training and education to Nebraska Businesses