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Cairns Tableland Tours specialises in small to medium day tours. Cairns Tableland Tours offer personalised tours to cruise ship passengers as well as tours for hotel guests staying in Cairns and Northern Beaches.
They also offer a day tour for Golfers in Cairns or Yorkey's Knob for hotel guests or ship passengers.
The most popular tour they offer for the cruise ship passengers is the Skyrail Rainforest Cableway, Kuranda, lunch at the award winning Frog's Restaurant in Kuranda and the Kuranda Scenic Railway.
A wide range of tour itineraries for guests who would like an all inclusive stay from three to seven days at very reasonable prices. You will have an endless choice for example, Skyrail Rainforest Cableway, Kuranda Railway, Coffee Plantations, Wineries, Waterfalls, Heritage Museums, ATV rides etc. A tour can be tailor made to suit the guests.
Cairns Tableland Tours prides themselves on providing an all inclusive value for money tour.
After your Cairns or Northern Beaches hotel pickup they travel south through Innisfail to Paronella Park. Paronella Park is a unique eco-friendly experience where history and romance are as one. Paronella Park is a magical place nestled amongst heritage gardens and acres of Australian rainforest situated on the banks of Mena Creek. The ruins of the Spanish Castle feature prominently on the grounds of Paronella Park. Visitors can explore the architecturally unique ruins of the castle and buildings of yesteryear, or wander through the lush gardens and Australian rainforest. Next is a leisurely lunch at Mena Creek Hotel with a choice of 5 meals and a beer/wine or soft drink is included. Mamu Tropical Skywalk is located 20 minutes from Paronella Park along the Palmerston Highway. The facility includes more than 1,100 metres of walking tracks through rainforest, linking the 10 metre cantilever, 350 metre elevated walkway through the canopy and the 37 metre high observation tower. This is an all inclusive small group tour in an air-conditioned mini bus.
After your hotel pickup they travel to the Skyrail Rainforest Cableway for your memorable journey up the Kuranda Range taking in the spectacular views over Cairns' Northern Beaches. There are two stops on your journey for you to enjoy the rainforest and wildlife. You will then be able to have a short visit in the sleepy little village of Kuranda where you will find many stalls and handicrafts. They then travel to Jaques Coffee Plantation in Mareeba, a working coffee farm where you will enjoy a guided tour of the plantation followed by a delicious lunch with coffee or tea. A few minutes away in Mareeba is the Mareeba Heritage Museum where you can step back in time and learn about the history of the Atherton Tablelands. To round off the day we will stop off at Emerald Creek Ice-Creamery where you can partake in your choice of one of their handmade ice creams. On our way back down the Kuranda Range you will have the option of stopping at the Henry Ross Lookout for a magnificent afternoon view of Cairns.
Skyrail Rainforest Cableway And Kuranda Scenic Railway Shore Tour
Pick up from Yorkey's Knob Marina or Cairns Cruise Ship Terminal.
Transport to the Skyrail Rainforest Cableway for your journey up to the top of the Tablelands to Kuranda.
Leisure time in Kuranda, perhaps visit the Koala Gardens, Kuranda Birdworld or the Australian Butterfly Sanctuary. There is also the Kuranda Riverboat cruise. (optional extras)
Lunch at the Kuranda Hotel. Choose from Steak, Chicken, Fish, Salads, Burgers, Pot Pie etc. Included is a beer/wine or soft drink.
Board the historical Kuranda Scenic Railway for your journey back down the range.
Transport from Freshwater station to Yorkey's Knob / Cairns or Port Douglas Cruise Ship Terminal.
Pick up from and return to port
Lunch at Kuranda Hotel including a beer/wine or soft drink
Skyrail and Kuranda Railway Tickets
Bottled water
Guide and Driver
Airconditioned vehicle, fully licenced and accredited.
Golf lovers, whether a beginner or a pro, will enjoy their all inclusive shore tour. They pick up from your hotel in Cairns or Northern Beaches and also Cairns Cruise Terminal and Yorkey's Knob Marina for Half Moon Bay Golf Club or Cairns Golf Club. Come and sample their lush, tropical golf courses for yourself. Their golf tours are limited to 10 people.
Pickup, to and from Cairns Cruise Ship Terminal or Yorkey's Knob Marina or Hotel
Transfer to Cairns Golf Club or Half Moon Bay Golf Club, Yorkey's Knob
18 holes of golf in
Motorised golf cart (share between 2 players)
Light lunch with a couple of beers/wines or soft drinks
Bottled water
Air conditioned vehicle with driver (who will be with you for the day)
Fully insured and accredited
Guaranteed to get you back to the ship in time
Golf club hire available (not included)
After your pickup from Yorkey's Knob Marina, Cairns Cruiseship Terminal or your hotel in Cairns or Northern Beaches, head towards the Skyrail Rainforest Cableway terminal at Smithfield where you will begin your memorable journey up the Kuranda Range taking in the spectacular views over Cairns' northern beaches and our World Heritage Rainforest.
There are two stops on your journey for you to enjoy the rainforest and wildlife as well as get a birds eye view over Barron Falls.
Your local guide will be at the skyrail terminal in Kuranda to transfer you the short distance to Kuranda Village where you can have a leisurely wander around the markets and shops.
Next, enjoy lunch with coffee or tea at the award winning Frog's Restaurant in Kuranda.
After lunch we will travel down the Kuranda Range to Cairns Aquarium, proudly displaying ten amazing North Queensland ecosystems from the world's most ancient rainforest to the world's largest coral reef to discover 70 different exhibits showcasing the rare and incredibly unique species of this region.
Enjoy presentations at Australia's only Deep Reef Tank and Queensland's largest Oceanarium.
Enjoy a full-day small-group tour from Cairns that visits Paronella Park, located south of Innisfail. Stroll around the elegant grounds of Paronella Park and see the beautiful gardens and the ruins of the Spanish Castle. Enjoy lunch at Mena Creek Hotel, a rustic Aussie country pub which serves up a great pub meal complete with a beer, wine or soft drink. In the afternoon they travel to the Tablelands to enjoy Milla Milla Falls, Curtain Fig Tree and Devonshire Tea in the Lake Barrine Teahouse taking in the stunning evergreen rolling hills that is the Atherton Tablelands.
Note: Information on listed products and services are provided by the operator and were correct at the time of publishing. Rates are indicative based on the minimum and maximum available prices of products and services. Please visit the operator's website for further information. All prices quoted are in Australian dollars (AUD).


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Florida voters will have to read carefully this election cycle as the wiley Republicans have pulled a ballot trick that appears to be intended to create some voter confusion.
In a surprise move on Friday, Senate Republicans persuaded Christopher Smithmyer, who had intended to run as a candidate in House District 100, to switch to the seat held by none other than Chris Smith,the Democrat's choice for incoming caucus leader and a Fort Lauderdale attorney. Smithmyer is a 29-year-old attorney who lives in Davie and teaches at the online Everest University.
The district is 43 percent black and is dominated by registered Democrats. The ballot for the District 31 seat based on Broward and Palm Beach counties will now look like this: Christopher "Chris" Smith, Dem v. Christopher "Chris" Smithmyer, Rep.
We've seen something like this before in 2006 when J.P. Planas, the third cousin of former state Rep. J.C. Planas, qualified to run in the Miami-based seat. The incumbent, J.C. Planas, sued saying that his cousin failed to file the proper paperwork and successfully knocked J.P. off the ballot.

subset: commoncrawl


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Cliven Bundy's Towering Tantrum of Entitlement
by Clarence Page
Here's an important lesson for politicians and talk show hosts: Be careful whom you put on a pedestal. They might fall on you.
Yes, I'm referring to the saga of Cliven Bundy. I'm laughing too hard at the Nevada rancher's political cheerleaders to be shocked by his famously ignorant slavery remarks.
Bundy became a hero with some Republican politicians, sagebrush libertarians and conservative talk show hosts after federal agents confiscated some of this cattle to help pay 20 years of grazing fees, totaling about
But hundreds of gun-toting supporters rallied to his side. So did Sean Hannity.
But that was before the 67-year-old rancher wandered way, way off-topic to expound on the subject of low-income black people, sending his most prominent supporters scurrying away like cats from a water sprinkler.
"I want to tell you one more thing I know about the Negro," he said in a 55-minute ramble that was quoted by a
Describing a public-housing development that he drove by in North Las Vegas, he said, "in front of that government house, the door was usually open and the older people and the kids -- and there is always at least a half a dozen people sitting on the porch -- they didn't have nothing to do.
Why? Because "they were basically on government subsidy," Bundy said. "They abort their young children, they put their young men in jail, because they never learned how to pick cotton."
Public housing needs cotton fields? Gee, thank you, Master Bundy.
But wait, there's more: "And I've often wondered," he mused, "are they better off as slaves, picking cotton and having a family life and doing things, or are they better off under government subsidy? They didn't get no more freedom. They got less freedom."
Ah, seldom has a freedom-loving American made a more spirited pitch for slavery. Bundy's vision of slave family life amazingly included no whips, chains, auction blocks, lynchings, wives torn away from husbands or children forever torn away from their parents. Maybe "Twelve Years a Slave" didn't make it to his part of Nevada.
At least, Bundy insisted in later interviews that he is "not a racist." That's a relief. I'd hate to think of what he would said if he had been trying to sound racist.
Republicans like Sen. Rand Paul of Kentucky and Sen. Dean Heller of Nevada who had supported Bundy's complaints about federal land policy, if not his lawbreaking, quickly condemned Bundy's remarks as offensive. So did
Hannity distanced himself from Bundy's remarks ("racist" and "beyond repugnant"), although not his cause. That cause never has sat well with conservative talk show host Glenn Beck, who charges grazing fees on his own Texas ranch. Having described Bundy as a "welfare rancher," freeloading his cattle at public expense on public lands, Beck said Bundy's outburst on race "shows you how unhinged from reality this guy is."
Never have I agreed with Beck more. Bundy criticizes people who "live under government subsidy" while he does precisely that. He has said on-camera that "I don't recognize the
Yet Bundy would not have received nearly as much support had there not been a legitimate political beef behind his antics. For decades, a sagebrush rebellion of western politicians and cattle ranchers has argued that the federal government owns too much land and governs environmental policies too tightly.
In fact, Bundy's dispute began with new protections for the desert tortoise, an animal against which he says he bears no grudge. That, too, is a relief. But, even as he deplores deadbeat dads, it doesn't help his cause for him to act like a deadbeat rancher.
Nevada Rancher Cliven Bundy's Race Rant Sends GOP Backers Fleeing
Available at Amazon.com:
Six Amendments: How and Why We Should Change the Constitution
Article: Copyright ©, Tribune Content Agency
Cliven Bundy's Towering Tantrum of Entitlement


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White Papers and Application Notes
Testing and Analyzing Complex Loading Conditions and Designs to Improve Subsea Cable Life
Tim Poole graduated from Cambridge University with a Masters degree in Engineering in 2008 and immediately joined JDR Cables Systems, a leading supplier of custom subsea oil and gas umbilical systems and renewable energy cables. He started in the Research and Development team, working on creating new products lines and testing umbilicals, which included fatigue, tensile and bend stiffness testing. He was then leading the introduction of FEA analysis of the umbilicals, focusing mainly on the mechanical and thermal characteristics.


text: In models where thermal equilibrium is imposed the total amount of energy absorbed from the incident radiation field should balance the total emitted energy in lines and continua. This constraint is not automatically satisfied, since the algorithm for calculating heating and cooling rates is based on the assumption that each spatial zone is at most marginally optically thick. As a check the total energy absorbed and emitted from the radiation field is printed at the end of the log file, along with the fractional error in energy conservation. An error greater than a few percent indicates an inaccuracy in the model results which may significantly compromise emission line strengths, for example. Such models should propbably be rerun with smaller values of emult.


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Summary and Keywords
The scientific community has made the urgent need to mitigate climate change clear and, with the ratification of the Paris Agreement under the United Nations Framework Convention on Climate Change, the international community has formally accepted ambitious mitigation goals. However, a wide gap remains between the aspirational emissions reduction goals of the Paris Agreement and the real-world pledges and actions of nations that are party to it. Closing that emissions gap can only be achieved if a similarly wide gap between scientific and societal understanding of climate change is also closed.
Several fundamental aspects of climate change make clear both the need for education and the opportunity it offers. First, addressing climate change will require action at all levels of society, including individuals, organizations, businesses, local, state, and national governments, and international bodies. It cannot be addressed by a few individuals with privileged access to information, but rather requires transfer of knowledge, both intellectually and affectively, to decision-makers and their constituents at all levels. Second, education is needed because, in the case of climate change, learning from experience is learning too late. The delay between decisions that cause climate change and their full societal impact can range from decades to millennia. As a result, learning from education, rather than experience, is necessary to avoid those impacts.
Climate change and sustainability represent complex, dynamic systems that demand a systems thinking approach. Systems thinking takes a holistic, long-term perspective that focuses on relationships between interacting parts, and how those relationships generate behavior over time. System dynamics includes formal mapping and modeling of systems, to improve understanding of the behavior of complex systems as well as how they respond to human or other interventions. Systems approaches are increasingly seen as critical to climate change education, as the human and natural systems involved in climate change epitomize a complex, dynamic problem that crosses disciplines and societal sectors.
A systems thinking approach can also be used to examine the potential for education to serve as a vehicle for societal change. In particular, education can enable society to benefit from climate change science by transferring scientific knowledge across societal sectors. Education plays a central role in several processes that can accelerate social change and climate change mitigation. Effective climate change education increases the number of informed and engaged citizens, building social will or pressure to shape policy, and building a workforce for a low-carbon economy. Indeed, several climate change education efforts to date have delivered gains in climate and energy knowledge, affect, and/or motivation. However, society still faces challenges in coordinating initiatives across audiences, managing and leveraging resources, and making effective investments at a scale that is commensurate with the climate change challenge. Education is needed to promote informed decision-making at all levels of society.
Keywords: climate change education, climate change, sustainability, Paris Agreement, systems thinking, system dynamics, Earth system science, transdisciplinary, simulation games, role-playing games
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How to Use
Map 1: The blockaded coasts.
The main starting points for blockade runners were Havana, Cuba; Nassau, Bahamas; the West Indies; and Bermuda. Many supplies also came via Matamoros to Brownsville, Texas, but transportation to needy areas (such as Richmond, VA) was limited because many small ports had no rail facilities.
Questions for Map 1
1. What ports would ships leaving Havana be most likely to head to?
2. What ports would ships leaving Nassau be most likely to head to?
3. What ports would ships leaving Bermuda be most likely to head to?
4. Note the location of the different Union squadrons. Why did they choose these particular locations? Considering the coastline they are attempting to block, describe why their task was so difficult.
5. If you commanded the Union Navy, which ports would you try to close first? Why?
* The map on this screen has a resolution of 72 dots per inch (dpi), and therefore will print poorly. You can obtain a high quality version of Map 1, but be aware that the file may take as much as 35 seconds to load with a 28.8K modem.


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Underarm Care after Recovery from Lymph Node Removal
Dear OncoLink "Ask The Experts,"
All my treatment has now finished, all body hair has grown back, and I am wondering about the hair under my arm where I had the lymph nodes removed with my mastectomy. What is the best method of hair removal, and should I avoid deodorant under this arm, or is roll-on ok? How do you care for this underarm?
Nancy Zieber, RN, MSN, CRNP, Oncology/Hematology Nurse Practitioner, responds:
An electric shaver would be the best. You can use a regular one as well, but of course you must be very careful not to cut yourself. That should not be such a problem now as they make safety razors and also razors with aloe to make the skin more smooth. Some women do not experience much hair growth in the radiated axilla (underarm), so you may find that the need for shaving is less in the radiated area compared with the opposite side. I think deodorant is fine, either roll-on or solid, although some women will experience less perspiration after radiation.


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What people are saying - Write a review
LibraryThing ReviewUser Review - MerryMary - LibraryThing
My daughter says when I get to Heaven it will be full of birds and wildflowers, and I will know all their names. That is why I collect books like this. Zim's book was my first and favorite nature guide. Read full review
LibraryThing ReviewUser Review - stefrand - LibraryThing
This is a good intro guide to bird species around the US. I got this book in elementary school at a book fair, and I still use it! Very helpful, with great pictures. Well-organized, easy to use. It ... Read full review
Other editions - View all
Common terms and phrases
adults similar American Goldfinch bark Barn Owl beetles bill birds birds migrate blue breast Brown Thrasher buff caterpillars chestnut color common crown dark DC E-May DC M-Apr Duck duller E-Apr E-Mar E-May Tr E-Nov E-Oct feathers feeding Female and young Female similar Female smaller field marks Finch flight Four toes Fox Sparrow gray greenish ground Hawk Hermit Thrush Heron Horned Lark House Sparrow insects kinglets L-Apr L-Nov L-Oct SF L-Oct WR legs M-Apr M-Apr SR M-Oct M-Mar M-Nov M-Oct M-Sept marshes moss nest Nuthatch Pale patch Permanent Resident throughout Purple Finch rootlets Sandpiper SF Permanent Resident similar to male Sparrow species spotted with brown StL L-Apr StL L-Mar streaked Swamp Sparrow tail throat throughout its range Thrush trees twigs unmarked Warbler weed seeds wild fruits wing bars winter Wood Thrush woodpecker woods WR M-Apr WR M-May yellow Yellow-billed Cuckoo Young and adults young similar


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Carry Hill School is a beautifully designed WordPress Theme for your child school, child care, but it would suit any children, art, craft or creative website. It comes with Visual Composer – Drag and Drop Page Builder which enables you to create your page content with ease. You can rearrange your content blocks any way you like. It also includes a powerful Premium Slider.
Another great feature is that it comes with Font Awesome Icon set. Font Awesome icons are vectors, and they're gorgeous on high-resolution displays. Also Iconsmind Icon Set is included. Additionally, this theme has very powerful and yet very easy to use theme options panel. There you will be making all your styling decisions. Carry Hill School WordPress Theme gives you an unlimited color palette through integrated color pickers and 9 color scheme presets. Also, on the subject of styling, it gives you an option of easily adding your own custom CSS rules. For text styling, this theme gives you access to more than 500 Google Web Fonts. Plus, Carry Hill School WordPress Theme is well documented and comes with free updates and support. This pack also includes Carry Hill Elementary School PSD files.
RTL Support
Feature List
- NEW! eCommerce Support has been added using the Ecwid online store
- Visual Composer – Drag and Drop Page Builder
- Ultimate VC Addons
- Timetable Responsive Schedule For WordPress
- Premium Slider
- Custom CSS rules
- Responsive layout
- RTL Support
- Powerful theme options panel
- Unlimited colors
- Google Fonts support (500+)
- 9 color presets that can be modified
- 5 page templates
- Shortcodes
- Iconsmind Icon Set
- Font Awesome Icon Integration
- Custom form builder
- Translation ready
- WPML Compatible
- Documentation
- Free Updates and Support
- PSD files included
- Setup Overview Video
- Update Overview Video
/* 2017-04-19 v2.2.5 */ - Ultimate Addons for Visual Composer 3.16.10 - Visual Composer 5.1.1 - LayerSlider 6.3.0 /* 2017-02-21 v2.2.4 */ - Plugin check in admin fix /* 2016-08-01 v2.2.3 */ - Minor CSS fixes /* 2016-07-12 v2.2.2 */ - Gmaps API key fix - Ultimate Addons for Visual Composer 3.16.6 - Visual Composer 4.12 - LayerSlider 5.6.9 /*-----2016-01-12 v2.1.1-----*/ 1. Minor fixes 2. NEW: Support for Ecwid Shop /*-----2015-10-07 v2.0.2-----*/ 1. Visual Composer 4.7.4 Security update /*-----2015-07-30 v2.0.0-----*/ 1. NEW: Visual Composer 2. NEW: Ultimate Addons for Visual Composer 3. NEW: Theme Options switched to Redux Framework 4. Deprecated: Bricklayer plugin /*-----2015-02-07 v1.3.2-----*/ 1. XML file updated (to pull content from new server) 3. Bricklayer update to 1.5.2 /*-----2014-12-19 v1.3.1-----*/ 1. WP 4.1 compatibility /*-----2014-11-29 v1.3-----*/ 1. Added an options for boxed single post 2. WPML compatibility 3. Required plugins update /*-----2014-07-07-----*/ v1.2 1. Firefox calendar arrows fix 2. Ipad inner page menu fix 3. Added and option to enable/disable icon on inner page title 4. Updates to required plugins /*-----2014-04-17-----*/ v1.1 - WordPress 3.9 compatibility - Bricklayer updated - LayerSlider updated to version 5.1 - Added an option for Sticky Menu - Added optional box slide in effects - Added additional Google Web Fonts /*-----2014-02-11-----*/ v1.0 - Initial release
Get the theme here !


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Justin Rose an emotional and popular champion at Merion
Phil Mickelson second for the sixth time as victor ends England's long wait for a Major winner
ustin Rose of England looks to the heavens in acknowledgement of his deceased father after putting on the 18th hole to complete the final round of the 113th US Open at Merion Golf Club in Ardmore, Pennsylvania. Photograph: Ross Kinnaird/Getty Images
ustin Rose kisses his wife Kate as he walks off the 18th green. Photograph: Adam Hunger/Reuters
Justin Rose of England kisses the US Open trophy after victory at Merion Golf Club in Ardmore, Pennsylvania. Photograph: Andrew Redington/Getty Images
Some scripts work out to plan, others are torn to shreds. Justin Rose, who experienced his fair share of travails in the early part of his career when missing cut after cut, finally found the promised land when landing the 113th US Open at famed Merion Golf Club and, as fate would have it, Phil Mickelson was – again – the one left to rue missing out.
Rose, in securing a maiden Major title and the first by an English golfer since Nick Faldo's win in the Masters in 1991, shot a final round 70 for 181, one over, which gave him a two-stroke winning margin over Mickelson, on his 43rd birthday, who finished runner-up for a record sixth time in the championship.
In a final round where the old course again showed its wicked side, Rose demonstrated tremendous composure. When all around him others were losing out to frustration, as heavy rough and brutally tight pin positions took their toll, Rose – whose only frailty came with a three-putt bogey on the 16th – closed the deal and retreated to the sanctuary of the scorer's hut to bide his time.
When Hunter Mahan bowed to the pressure of the chase and, then, and more importantly, Mickelson failed to find the required birdie on any of the closing holes, Rose could finally allow himself to wallow in the new status as champion.
Mickelson's closing bogey actually saw him shoot a 74, which brought him into a two-way share of second with Australian Jason Day.
It was a day best forgotten for some.
Luke Donald, who got to watch each and every one of playing partner Rose's 70 strokes, had a catastrophic start which saw him double-bogey the sixth on the back of three straight bogeys from the third hole.
Others struggled too, with Steve Stricker's triple-bogey eight on the second ending his quest for a first Major before it ever got going.
The title had seemed destined for Mickelson: on his birthday, and going into the final round with the memory of five runners-up finishes in the championship. Lefty – who had delayed turning up until just hours before his tee time last Thursday so that he could attend his daughter's graduation from school – was the people's champion.
Or so it seemed.
Undeterred, Rose went about ripping up Mickelson's script; and wrote his own.
"Every time I think of the US Open I just think of heartbreak," said Mickelson, who double-bogeyed two of his opening five holes to make life difficult and ultimately impossible for himself. "For me it's very heart breaking.
"This could have been a really big turnaround for me on how I look at the US Open and the tournament that I'd like to win, after having so many good opportunities."
Of course, Mickelson contributed to the drama when holing out from rough with a 54-degree gap wedge for an eagle on the 10th. If that audacious shot seemed as if it would energise his round, it didn't and, when he overshot the short 13th green and ran up a bogey, the door was opened for whoever wanted to walk through it.
Day made a tremendous effort, until he bogeyed two of his last five holes. And when the toughest questions were asked, Rose was up to the task. It was far from easy or straightforward, as five birdies along with five bogeys testified.
His back-to-back birdies on the 12th and 13th were followed, though, by bogeys on the 14th – where he failed to get up and down from a greenside bunker – and the 16th, when he three-putted. But he held his nerve on the tough 17th and the unforgiving 18th to finish par-par.
On the last, he boomed a drive down the middle of the fairway. Tempting fate almost, the ball landed just behind the plaque which commemorated Ben Hogan's famed one-iron approach to the 72nd hole in the 1950 US Open. Taking up the challenge, Rose hit a mid-iron approach that covered the pin and ran through to the back of the green.
"I saw my ball in the fairway I thought 'this is my moment'," he said afterwards. "You know, I have seen that Ben Hogan photograph a million times and suddenly it was me hitting middle of the fairway. I just tried not to get too ahead of myself. I hit a beautiful four iron into the green. I'm just so glad it all worked out."
Using a fairway wood, he rolled his birdie attempt which finished on the lip. It was enough. The tap-in marked his rise in status to that of a Major champion, and those 21 successive missed cuts that marked the start to his professional life on tour were very much a thing of the past.
"It's been too long, really," said Donald, commenting on the long gap – some 68 Majors – since Faldo's triumph. "I think we've had a lot of talent come out of England and hopefully we've broken our bad period. This will be a great week for Justin and for England."
Rose, who first burst onto the golfing scene when finishing fourth as a teenage amateur in the 1998 British Open at Birkdale, finally, bridged that gap.
On the day that was in it, he dedicated the win to his late father Ken, who passed away after a long battle with cancer in 2002.
"You saw me look to the heavens with it being Father's Day — I was just trying to remember my dad. I don't know what to say, I'm thrilled."


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Historically, the Internal Revenue Service (IRS) has identified several million businesses each year that may have failed to file tax returnsmore than it can thoroughly investigate. IRS has had difficulty determining if these businesses that IRS identified are still active and thus required to file a tax return. As a result, IRS has pursued many inactive businesses, which has not been a productive use of its resources. In addition, IRS has had no estimate of the nonfiler population. Given the lack of data, IRS has neither a clear estimate of the revenue loss from businesses not filing required tax returns nor a clear basis for allocating resources to addressing this type of noncompliance.
Recently, IRS has begun to use third-party information about payments between businesses and other available data as indicators of business activity. The intent is to prioritize cases with the most revenue potential, using just the third-party information that IRS already possesses.
IRS has the potential to increase the revenue it collects from noncompliant taxpayers by increasing the effectiveness of its business nonfiler program, but the efficiency and productivity of IRS's efforts to ensure compliance by business nonfilers have been hampered by a lack of data. IRS cannot develop a comprehensive estimate of the business nonfiling rate and associated revenue loss because it lacks sufficient data on the population of businesses. Absent such an estimate, IRS will have no basis to know what priority to give its business nonfiler program and whether resources should be reallocated from other enforcement efforts.
IRS has not used private sector data that it could obtain to verify taxpayer statements about whether a business is active and a tax return should have been filed. A number of private companies maintain business activity data, such as data on a business's gross sales and number of employees, which could aid IRS in making these determinations. Dun and Bradstreet is one provider of such data. Its databases include information on business name, address, amount of sales, and number of employees. GAO's analysis of Dun and Bradstreet data showed they could be used to identify business activity that IRS was not aware of. For two states, GAO analyzed 2007 data on the businesses that IRS initially identified as potential nonfilers but later determined were not liable to file returns. Of these, GAO found 7,688 businesses where IRS data indicated little or no business activity, but Dun and Bradstreet data showed business activity as measured by sales totaling $4.1 billion.
GAO also performed a similar analysis using data on federal contractors. GAO found 13,852 businesses listed on the federal contractor registryindicating likely business activityeven though IRS had determined they had no filing obligation. GAO did not determine which non-IRS data would be most useful nor did it examine the capacity of IRS's systems to use such data on a large scale.
Until recently IRS also has not had a way to prioritize cases in its inventory. IRS modernized its business nonfiler program in 2009 by incorporating income and other data in its records indicating business activity. Active businesses, for example those with sales or employees, generally have an obligation to file a return. IRS's Business Master File Case Creation Nonfiler Identification Process now assigns each case a code based on these data. IRS uses the code to select cases to work with the goal of securing tax returns from nonfilers and collecting additional revenue. This is a significant modernization, but IRS lacks a formal plan to evaluate how well the codes are working. Absent evaluation, IRS will not know to what extent the initiative is successful and whether it has resulted in a better allocation of enforcement resources.
While potentially significant, the revenue gains that may be available through IRS actions to identify and pursue more business nonfilers cannot be quantified due to the lack of data on the size of the business nonfiler problem and the effectiveness of IRS's new process. As GAO recommended in its August 2010 report, to better allocate and use its enforcement resources, IRS should develop at least a partial estimate for the business nonfiler rate based on its existing inventory of cases. In addition, IRS should
IRS has agreed to start reviewing or implementing these actions. As of December 2010, IRS has laid out planned implementation steps up through January 2013. The scope of GAO's recent work did not extend to analyzing IRS's capability to meet these implementation plans. The potential revenue significance merits GAO tracking of IRS's progress over the next few years.
The information contained in this analysis is based on the related GAO product under the "Related GAO Products" tab.
For additional information about this area, contact James White at (202) 512-9110 or firstname.lastname@example.com.
The Internal Revenue Service (IRS) does not know how many businesses failed to file required returns, nor does it have an estimate of the associated lost tax revenue--the business nonfiling tax gap. Many cases it does investigate are unproductive because the business does not owe the return IRS expects. GAO was asked to assess (1) the data challenges of estimating the business nonfiler tax gap, (2...
Jump to another area below related to this mission.


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Food & Drink
National parks free this weekend
By Maggie Blaha, Special to CNN • Updated 21st April 2014
View Gallery
8 Pictures
Looking for something free to do this weekend? Check out a national park.
Entrance fees will be waived at all U.S. national park sites this Saturday and Sunday, April 19-20, to kick off
National Park Week
, which runs through April 27.
Visitors still have to pay the usual fees at campgrounds and concession stands.
With more than 400 National Park Service sites covering 84 million acres in the United States, there are plenty of spots to explore.
And if you think national parks are just places where you can take a hike or be one with nature, think again.
The Statue of Liberty is a national park. So is Gettysburg National Military Park. Parks and scenic trails like Yellowstone National Park in Montana are not the only areas that make up the National Park Service. Monuments, battlefields and historic sites are also given this distinction.
"National parks are closer than many people think; every state has at least one," said Kathy Kupper, a spokeswoman for the National Park Service. "These range from big natural parks to smaller historical sites."
In addition to free admission this weekend, many parks are offering
special events
throughout the week. You can participate in the "waterfall challenge" at California's
Whiskeytown National Recreation Area
, commemorate the opening battle of the American Revolutionary War at
Minute Man National Historic Park
in Massachusetts or experience how Civil War soldiers lived in a living history encampment weekend at
Appomattox Court House National Historic Park
in Virginia.
Many of the parks will have special activities for kids on
National Junior Ranger Day
on April 26.
In 2013, national parks across the country saw 273.6 million visitors, with an average of 784,000 visitors per day during the month of April when National Park Week is always observed.
"National Park Week definitely raises awareness of national parks as great places to visit," Kupper said. "April is a good time, as the weather gets better, to remind people of all the great opportunities to get up and get out in a park."
What do you consider the world's best national park?
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Posts Tagged 'breakthrough in visual technology'
Winner Winner, y'all
March 24, 2017 2 comments
With EXHIBITORLIVE a week plus in the rear view mirror, it is tempting to recap the buzz of the show floor and all the groovy emotional points of the show, but I am going to skip that as it has been done and I am going to focus on a very serious matter. The matter of sharing what is apparently an extremely important matter and cornerstone of the 2017 Optima EXHIBITORLIVE experience – WHO WON THE DANG GUMBALL COUNTING CONTEST!
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Use index separations to make shirts ready for the runway.
One great way to elevate the level of detail and quality that a screen printer can handle is to look at reproducing fine-art designs onto garments. The challenge to re-creating fine artwork tends to relate to the fact that styles and media have to be simulated through some form of halftone to be printed onto the garment. An additional challenge to fine-art reproduction is that it may cost more time in hours and effort than most of the profitable work that comes in the door. Having a standard setup that can qualify the order up front can prevent headaches in production.
How to qualify art
Qualifying the artwork for screen printing is the process of estimating the time and effort it will require to reproduce the design, balanced against the amount of garments that the client will need. Assuming that the volume of garments justifies the effort, then working with the artwork to recreate it in the quickest, and most accurate way is essential.
A quick review of the artwork should reveal the best prospect for separation and reproduction, depending upon the way the artwork was created and the different prepress and printing methods that your company is comfortable using. If your production department has worked with index separations and stochastic dots before, then these commonly the best, unless the artwork has an excessive number of blended colors. Designs that are created using chalk, charcoal, graphite (pencil), and pastel all seem to work very well with the small square dots of index separations because the grain in the image echoes the dot pattern.
The other advantage to using index on hand-drawn artwork is that a traditional halftone separation will punch holes into the lines and tones in the image to establish the pattern, which can sometimes make the image appear dull or too light on the garment. A separation that uses an index pattern is created using a dot frequency that will maintain the edge quality more effectively on details and small lines.
Did you enjoy this article? Click here to subscribe to the magazine.


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By Terry Erdle, executive vice president, skills certification, CompTIA
Which types of end users care about this certification?
The cloud computing market is growing exponentially, and there are scores of IT and business positions that require cloud competence. We think CompTIA Cloud Essentials will help businesses gain and validate foundation-level cloud computing knowledge and skills.
Do you have an example of a VAR leveraging a CompTIA certification to win a deal?
This certification is still in its infancy, as it was launched in late 2011. Approximately 140 individuals have earned the credential to date. We can't direct you to a specific, particular deal win that's attributable to earning the cloud certification. But, we're confident that resellers who add CompTIA Cloud Essential to their list of qualifications will see measurable benefits in dollars and cents. The cloud brings fundamental changes and challenges to the VAR community, which must continually adapt in order to succeed. Businesses are pursuing a cloud strategy for many reasons — such as cost savings, agility, or enabling new business opportunities — and decision makers from various areas are likely to inquire about cloud solutions. Resellers need to educate themselves on cloud business opportunities. CompTIA Cloud Essentials is a good first step.


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Cleaning Prices in Williamstown
Whether you're moving house and need comprehensive care for your property or you want to set up a regular cleaning plan, you'll be happy to find out our cleaners' rates in Williamstown will fit your budget. Combine 2+ of our services and receive special discounts on your tailored service package. Contact us at (03) 8672 3969 for a free quote and any information you need or leave your details in our contact form to request your personal quote.


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- Shop
- >
- Special Collections
- >
- The Royal Collection
- >
- Royal Red Panda Print
Royal Red Panda Print
25 45 $25.00 - $45.00
Signed, archival print on acid free paper.
Signed, archival print on acid free paper.
Cocoally is an artisan boutique and clothing line by artist Ally Burguieres and her vegan rescue Chihuahua, Cocoa. We are located at 630 St Ann St in the New Orleans French Quarter and 1330 Prytania in the Lower Garden District. Select items are also available at Ally's single-artist gallery, Gallery Burguieres, at 736 Royal Street, and at boutiques around the US. Click here for the full Cocoally Story!
Cocoally Vegan Boutique
New Orleans
630 St Ann Street 70116
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Riding the Timber Trail - Pureora Forest
The Timber Trail is addition to the New Zealand Cycle Trial Network, located north of Taumarunui, in the north island of New Zealand. A must do!
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A former logging stronghold, the Timber Trail has been restored into a national cycle trail. Follow old tramway lines to the flanks of the culturally significant Mt Pureora then along the Hauhungaroa Range before dropping down to Ongarue. Remanents of original railways, settlements and an historic way of life can be seen scattered throughout the trail.
Complete the entire trail over two days or select a section (northern or southern) of your choice to accomplish.
Day 1 (40 kms)
Begin at Pureora Village and head south towards Mt Pureora. As you pass the 4 km marker the trail will climb for the next 14 kms until it reaches the western flanks of Mt Pureora. From there descend a steep and rocky downhill (it is recommended to walk parts of this section) until you reach Angel's Rest. This is a great place to stop for lunch and to refill your water bottle. Finish the day at Piropiro Flats, campsite facilities and other accommodation available nearby.
Day 2 (42.7 kms)
Head south from Piropiro Flats into the regenerated Podocarp Forest. Soon you will reach the trails longest and highest suspension bridge, the Maramataha Bridge. Once over the bridge, cycle a short, steep climb to the most northern point of the tramline, the cleared area known as 'the terminus'. From here the remainder of the trail gradually descends towards Ongarue. Points of interest along this section of the trail include the old Mystery Creek triangle where locomotives once turned, amazing views of rocky bluffs in the valley and the historic no.11 campsite. The Mangatukutuku suspension bridge near the site of the historic viaduct is a real highlight as well as the Ongarue Spiral and tunnel. After descending the Ongarue Spiral, cycle along flat sections of the trail between native forest and farmland before ending at the Ongarue carpark.
Hire, Transport and Accommodation
Transport providers, accommodation and mountain bike hire can be found in Taumarunui and surrounding townships.
Pureora Village is located along State Highway 30, North-east of Taumarunui, just past the Pa Harakeke Centre turn left on to Barryville Road and travel 2km to the beginning of the trail. Please note that Maraeroa and Barryville roads are gravel.
Pureora Village may also be accessed by turning onto Barryville Road from State Highway 30 and travelling 2.5km to the beginning of the trail.
To get to Ongarue turn off State Highway 4 on to Ongarue-Waimiha Road. Turn right, cross the river at Tuhua Road then left onto Ngakonui-Ongarue Road. The trail begins at the Bennet Road Carpark 2km from Ongarue.


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Zechariah's Call for Judah's Return
The opening verses of Zechariah's book contain warnings to the people for breaking the law, warnings that prompted the people to show repentance. When God warns His people of their sin, that is always His goal, namely, their repentance. Matthew ...Read More
Zechariah's First Vision
Zechariah's first vision concludes with a word from the Lord that the people were not to take their continuing subjection to a foreign empire as proof that God had forgotten them. God reiterated His promises that He would bless His ...Read More


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Gillian Ussher Art
Hungarian Vizsla Portrait Fine Art Giclee Print
Amber the Vizsla was the model for the original artwork from which this print was produced. The original artwork was hand drawn in 2016 using Faber Castell and Unison pastel on Ingres paper. These prints have been giclée printed onto Hahnemuhle Photorag paper which is textured just like pastel paper. Even as the artist, I find it difficult to tell the original from the prints.
All prints are hand signed and numbered in a limited edition series of 250.
Unframed prints are not mounted, but supported by a sturdy backing board and covered with clear wrapping. Optional frame is a black with a delicate grain texture, and completed with an ivory mount.
Huge thanks to Jenny Kemp Photography for allowing me to use her reference image for this portrait.
A brief history of giclée printing
The word Giclée ("gee-clay"), is based on the French verb gicler which means "to squirt or spray" and was originally coined by printmaker Jack Duganne in 1991. Giclée printing is a fine art digital printing method using specialist archival pigment inks and acid-free papers; creating gallery-quality inkjet prints with excellent depth of colour, longevity and stability.
The print process involves squirting microscopic dots of pigment ink onto high quality fine art or photographic papers using sophisticated high-end inkjet printers with exceptional accuracy, wide tonal range and colour gamut.
Studies have shown that Giclee Prints colour vividness can last in excess of 200 years with tests by independent bodies such as Wilhelm Research and printer manufacturers such as Epson. This gives assurance to collectors and art buyers of this type of printing method.


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Welcome to Week 5 of the SoConversation, featuring The Citadel beat writer Jeff Hartsell of the Charleston Post and Courier, Elon beat writer Adam Smith of the Burlington Times-News and Chattanooga beat writer John Frierson of the Chattanooga Times Free Press.
Perhaps the most interesting thing that happened in the SoCon last week took place away from the field. College of Charleston held an athletics committee meeting last Friday to discuss a possible move to the Colonial Athletic Association.
In the meeting, CofC AD Joe Hull called SoCon basketball �invisible on a national stage� and said membership in the league �hurts recruiting� in every sport but baseball, and makes it hard to schedule quality foes. (The Cougars don�t play football). SoCon commissioner John Iamarino said he�s still working hard to keep CofC in the SoCon.
What�s your view of Hull�s comments and the Cougars� future in the league?
JEFF:We can agree or disagree on the truth of Hull�s statements. SoCon hoops does not have a high profile nationally, at least since Steph Curry left Davidson, although a couple of nice NCAA Tournament runs by the Cougars themselves might have helped that situation.
But what�s the point of burning bridges on the way out the door? Hull�s comments were not diplomatic, to say the least, and will lead to some awkward moments for at least this basketball season and in the future, should he fail to round up the Board of Trustees votes needed to make the move.
And perhaps his comments reveal the lengths he feels he needs to go to convince board members that moving to the CAA is the right thing to do.
Simply noting the uncertain future of SoCon membership (Georgia Southern and App State want to play FBS football) and extolling the virtues of the CAA should have been enough, if CofC people really think it�s the right thing to do. In my view, it�s certainly a difficult decision.
With the losses of VCU, Old Dominion and Georgia State, I�d say the CAA is marginally a better hoops league than the SoCon, instead of the clearly superior league it used to be. The move to the CAA will do harm to a successful Cougar baseball program, without a doubt. And there are ramifications far beyond the athletic department.
The CofC board meets again in mid-October. If the Cougars end up not making the move, Hull will have a lot of �splainin to do.
JOHN:I don�t know if I would have phrased things the way Hull did � the term �invisible� is pretty darn strong � but I�m not going to disagree with everything he said.
The SoCon is hurt in numerous ways by not having a broadcast television deal, but at the same time I don�t know what one would cost. And playing on NBC Sports, as the CAA does, isn�t the same as being on ESPN2.
I�ve said multiple times that if you�re going to spend a lot of money on a move (like App State or Georgia Southern going up to the FBS) make it one worth the expense and effort. I still don�t see the Cougars going to the CAA as worth the trouble, but I also still think they�re out the door.
ADAM:As for Hull�s blistering words and College of Charleston�s future in the league, well, read the line below in your best sorority girl inner monologue.
Awk � ward.
CofC has to have at least one if not both Sperrys out the door, right? Why else would Hull and the school�s athletics committee chairman (Dwight Johnson) present the material in such a compelling way?
You can�t open up the flamethrower, scorch the earth and then go sit in a SoCon ADs meeting like nothing happened, can you?
To me, once stuff like that has been said in such a public forum, it�s almost impossible to turn back.
Remove the commentary and the emotions and this becomes the latest step in the domino effect that began playing out in the spring, when CAA commissioner Tom Yeager called Iamarino with the message that, in his hunt to reload the depleted CAA, he would be contacting some SoCon members.
Four months ago the SoCon�s initial fear was that CofC was the most likely to leave. Now that�s looking like a reality, especially with the school�s brass seemingly enamored with the CAA�s presence in the Mid-Atlantic and Northeast.
I was in sticky Statesboro, Ga., for Elon�s game at Georgia Southern on Saturday night. Hull�s words then were just a day old and the CofC / CAA issue was a prevalent press box topic.
By the way, as the sage Todd Shanesy of the Spartanburg Herald Journal and others have pointed out, College of Charleston hasn�t won the �invisible� SoCon since 1999.
Before we discuss what happened elsewhere in the SoCon, let�s take a moment to go over what happened with the teams we cover. Chattanooga got thrashed in the fourth quarter by Appalachian State, Elon nearly stunned the Georgia Southern in Statesboro and The Citadel�s roll hit a non-conference speed bump. Thoughts?
JOHN:The Mocs got off to a nice start by forcing a couple of turnovers and taking a 10-0 lead. Not much good happened after that.
The score was 10-10 heading into the fourth quarter and the Mountaineers dominated the final 15 minutes. UTC had turnovers on three straight possessions and the game ended in a rout.
The strangest part of the game was UTC�s offense, which looked nothing like the spread system the Mocs had been running.
It was much more basic and App State had little trouble defending it. The Mocs didn�t hit the 100-yard mark in total offense until midway through the third quarter.
ADAM:In the minutes after Elon�s near-miss at Georgia Southern, one of the first things coach Jason Swepson said outside the locker room was that the Phoenix proved it could play with any team in this league.
Obviously, whether that holds true remains to be seen in the next two months.
But that sense of confidence had to be the most significant of several positive takeaways as Elon departed Paulson Stadium, where Georgia Southern has won 12 straight home games, the second-longest active streak in the FCS.
Elon led at halftime (13-6), late in the third quarter (20-16) and was tied at 23-23 with Georgia Southern with less than four minutes remaining. Then with less than two minutes left, the Phoenix came 12 yards shy of the potential winning touchdown before a turnover pulled the plug.
Thomas Wilson threw for 302 yards. Aaron Mellette caught two touchdown passes. Kierre Brown (five catches, 110 yards) and Jeremy Peterson (two catches, 77 yards) stepped up big. And Elon�s defense withstood Georgia Southern�s triple option sufficiently enough to make it to crunch time with a chance to win.
An upset victory would have been tremendous for Elon. But still, it amounted to a good night�s work.
JEFF:I thought The Citadel would give N.C. State a much better game, but the Bulldogs did not for a couple of reasons.
The Wolfpack is better than I gave it credit for, and N.C. State took the Bulldogs much more seriously than some FBS teams have in the past (cough, cough, South Carolina). N.C. State was prepared for the option, and in the end just too big and fast for the Bulldogs.
Good news is the 52-14 loss does not disqualify The Citadel from winning the SoCon title. Over the last five seasons, SoCon champs (and co-champs) are 1-6 against FBS teams, the losses by an average score of 39-16. The lone win was App State�s epic upset of Michigan in 2007.
Here are last week�s results: North Carolina State defeated The Citadel 52-14, Appalachian State defeated Chattanooga 34-17, Georgia Southern defeated Elon 26-23, Samford defeated Western Carolina 25-21, Furman defeated Presbyterian 31-21.
What caught your eye during Week 4?
JEFF:I�m not surprised that Western Carolina gave undefeated Samford such a tussle. From all accounts, Mark Speir has the Catamounts playing with an edge that they�ve sorely lacked in recent years.
I was surprised that Elon gave Georgia Southern such a battle in Statesboro. Looks like the Eagles were overrated in preseason polls, and that Elon has made nice progress since that opening debacle against North Carolina.
And how about this Sean Price fellow at App State? The Mountaineers are 2-0 when the 6-5 freshman receiver plays (he�s caught 18 passes for 233 yards and three TDs in the games he�s played) and 0-2 when he does not (he was suspended for East Carolina and The Citadel). Jerry Moore needs to find a way to keep this guy eligible.
JOHN:I predicted in this space last week that Samford was going to have its hands full with the Catamounts. I did not predict that Georgia Southern would need a 32-yard field goal with a little more than three minutes left to beat Elon.
And I sure wouldn�t have predicted that UTC / App State would be the most lopsided SoCon game of the weekend. After four games, the Mocs are last in the SoCon in scoring and total offense. I wouldn�t have predicted that, either.
ADAM:Samford rallying from down 21-10 in the fourth quarter at Western Carolina and improving to 4-0 overall for the first time since 1995 � which just so happened to be a glorious time in my life.
High school. A full head of hair. A speedy metabolism. My �86 Chevy Blazer. Ah, the memories �
Back on topic, Samford seems to be a well-scheduled 4-0, with wins against Furman, West Alabama, Gardner-Webb and Western Carolina. And sure, it was Western Carolina�s 16th straight SoCon loss, but the Catamounts, as we�ve said, seem to be friskier under new coach Mark Speir.
N.C. State breaking open a 7-7 game with Citadel and running off 35 unanswered points into halftime certainly qualified as eye-catching. When the Twitter machine told me about Darien Robinson�s 65-yard TD in the first quarter, I was thinking Citadel might be spinning some more magic.
And how about the two-pronged effect of App State pulling away from Chattanooga. The Mountaineers bounced back a week after getting drilled by Citadel to score a key road victory. The flip side was a 10-10 game in the fourth quarter � and another meaningful opportunity � dissolving into the latest hard-to-stomach defeat for Chattanooga.
Even if Johnny Frierson wasn�t such a sweetheart, you�d still have to feel for the Mocs.
Here are this week�s matchups: Western Carolina at Furman (1:30 p.m.), Wofford at Elon (1:30 p.m.), Coastal Carolina at Appalachian State (3:30 p.m.), Chattanooga at The Citadel (6 p.m.), Samford at Georgia Southern (6 p.m.). Any predictions on what�s to come this weekend?
JOHN:This is pretty much a MUST-WIN game for the Mocs, who certainly didn�t expect to be 1-3 at this point in the season. A loss in Charleston would mean a 1-4 start, which would be pretty darn stunning. I don�t know if it will help or hurt the Mocs to play with a measure of desperation, but I suspect we will find out Saturday night.
Samford / Georgia Southern didn�t look like a monster matchup at the start of the season, but the Bulldogs are 4-0 with a pair of conference wins. We�ll find out if Samford is for real Saturday and we�ll also learn a lot about the Eagles.
I think the desperate Mocs get a win in Charleston, Furman wins a close one, the Terriers roll, the Eagles pull away late and App State cruises past Coastal Carolina.
JEFF:Ah, the long-awaited �meat of the schedule� arrives. Samford has cruised to a 4-0 start and cracked the Top 25, but plays ranked FCS squads (Georgia Southern, Citadel, App State, Wofford) in four of its next five games.
Chattanooga (1-3) had high hopes for this season, and will carry a hint of desperation with it as it heads to The Citadel, where I fully expect a fourth-quarter battle. Wofford should be extremely well-rested after its comfortable early schedule (Gardner-Webb, Lincoln, Western Carolina and Open Date, which proved a tougher foe than Lincoln).
Western Carolina at Furman is vital for both teams. The winner still has hope for a successful season, the loser not so much. Winners are Furman, Wofford, App State, The Citadel and Georgia Southern.
Anybody have Citadel and Samford at 2-0 in the league heading into the last weekend of September? Anybody?
Here�s a recommendation: Furman had better take care of business at home against Western Carolina, because the schedule moves in a challenging direction starting with next week�s short trip to Wofford.
There�s something about that Chattanooga / Citadel game that feels like a wild one could be in the works.
If fumble-prone Georgia Southern quarterback Ezayi Youyoute can stop it with the butterfingers routine, the Eagles should be responsible for Samford�s first loss of the season.
As for Wofford / Elon, I�m interested to see how Elon�s defense handles back-to-back weeks of the triple option. Elon middle linebacker Jonathan Spain made 16 tackles at Georgia Southern. Then on Sunday he said he stayed plopped on the couch while trying to ride out the soreness from the collisions and cut-blocks.
With Wofford and a 230-pound animal named Eric Breitenstein coming to Elon this weekend, ready the ice baths and massage therapy.
If you�ve got a question, e-mail the writers at firstname.lastname@example.com, email@example.com or email@example.com. The guys are also on Twitter: @Jeff_fromthePC, @adam_smithTN and @MocsbeatCTFP.


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Update: We have a winner (this contest is closed!)
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Congratulations Megan – comment #52
The giveaway today is SO "SWEET"!!! Have you heard of the book Sugarlicious? It is a colorful and inspiring book filled with projects for all ages!
Sugarlicious was written by the talented Meaghan Mountford who you can find at The Decorated Cookie or on Craft Gossip. The book is filled with wonderful edible treats such as decorated marshmallows, cake pops, fondant figures, cupcakes and much more!
Along with other holidays, you can plan for spring and Easter now with some of these great goodies!
My favorite thing about this book is that it doesn't just have great recipes but it has great tips and tricks for decorating sweet treats!
Now, one lucky reader will get a chance to win this wonderful book!
To enter to win a copy of this book, simply leave a comment here stating why you would like this book.
Please leave a separate comment for each entry.
1. Follow Divine Party Concepts on Facebook.
2. Follow Divine Party Concepts on Twitter and tweet about this giveaway.
Giveaway ends Thursday, March 15th, 2012 at midnight (CST). Winner will be chosen randomly and announced the following day.


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Buchholz, Red Sox down ChiSox
Chicago, IL – Boston put two runs across in the first inning and that is all Clay Buchholz would need as the right-hander went seven strong innings to help the Red Sox to a 6-2 win over the Chicago White Sox in the finale of a three-game set.
David Ortiz drove in two with a single to left in the opening frame off Hector Santiago (1-3), who struck out nine over six innings of work. Santiago got the start in place of Chris Sale, who was scratched with shoulder tendinitis but is expected to make his next scheduled start.
Buchholz (7-0) allowed just a run on five hits to become the first Red Sox pitcher since Josh Beckett in 2007 to start the season 7-0.
"Confidence is a big thing," Buchholz said. "It's fun pitching when you're (going) good."
Ortiz and Jacoby Ellsbury had two hits apiece while Daniel Nava drove in a pair.
With one away in the first, Jonny Gomes was hit by a pitch and Dustin Pedroia doubled, setting up Ortiz to drive in the game's first runs.
Chicago threatened in the bottom of the first when Alexei Ramirez and Alex Rios drew walks, but Gomes' diving catch in left field robbed Paul Konerko of an extra base hit to end the inning.
The White Sox broke through with a run in the third. Tyler Flowers reached on an infield single and eventually scored on a Rios ground out to short.
Buchholz gave up a single in the fourth, fifth and sixth innings, but none of those baserunners reached second base.
"He made pitches when he needed to," Konerko said. "He's a great pitcher."
Boston bats gave their bullpen two insurance runs in the eighth when they loaded the bases for Will Middlebrooks, whose sacrifice fly gave the Red Sox a 3-1 edge. Mike Napoli then scored on a passed ball.
Nava's two-RBI single to left in the ninth plated Ellsbury and Gomes, and Konerko's solo homer off Andrew Bailey in the bottom half rounded out the scoring.
Game Notes
Buchholz joined Patrick Corbin (7-0) and Matt Moore (8-0) as the only pitchers in the majors with at least seven wins and no losses. Buchholz has also exceeded 100 pitches for the ninth straight game ... Alex Rios extended his career-best hitting streak to 16 games.


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This haunted train ride is officially the best way to celebrate Halloween
Forget haunted houses, this is the spooky attraction you need to experience this October.
Forget haunted houses, this is the spooky attraction you need to experience this October.
If you're someone who loves haunted houses and trains, then we've found a spooky adventure that has your name written all over it.
The New Hope and Ivyland Railroad will host a grown-ups only (teens are included though!) Haunted Train Ride through Pennsylvania this year. The scary 40-minute ride departs from the quaint small town of New Hope, and it's sure to be full of freaky frights. Plus, tickets start at just $35!
Riders can expect to see a few ghostly guests on board this PG-13 train ride. "When this train leaves the safety of the station, you are tossed into the hands of the unknown," says the rail line's website. "Our creatures are sure to frighten the strongest of heart, and test the nerve of all onboard."
The old-school trains are outfitted with vintage seats and equipment, all from the 1910s through 1930s, which makes the adventure even more authentic.
You can catch the spooky ride on weekends and a few weekdays starting October 11 and running through Halloween. Riders can choose from 7:00 p.m. through 11:00 p.m. on weekends, but you better nab 'em now because tickets are selling out fast. And while this eerie train ride is reserved for adults, take note the rail line also hosts a little kid-friendly Trick or Treat ride, also starting on October 12.
(h/t Pop Sugar)


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Representative, 74th District
We are having some interesting and unusual bills introduced. Bills creating term limits, protecting Second Amendment rights, addressing abortion, and bills restricting the use of public funds for lobbying efforts are now in the hopper for possible consideration. While it is improbable that all of these will have a committee hearing, some are already on the committee schedule.
The abortion bill getting the most attention is called heartbeat legislation. It basically says that if a heartbeat is detectable in a fetus, an abortion cannot be performed. I don't know if this will have a hearing, but odds are good that it will.
A bill that would prohibit agencies from lobbying the legislature if they receive tax funds is written very broadly and may not be workable. This one appears to be so broad that state agencies may not be able to talk to legislative members about their budgets and programs. While some ideas sound good initially, the reality is working with these organizations is necessary for budget and policy discussion.
Our telecom bill that deregulates and begins the process of eliminating the Kansas Universal Service Fund (KUSF) was worked and passed on the House floor Friday. It certainly is not a perfect bill, but seems to protect rural areas from rate increases and sets the stage for changing technology and improving broadband speeds.
The Taxation Committee has held hearings on the governor's proposal, but has not taken any action. Passing a budget and tax package that balance will be the main event this year as the governor's budget package does not balance without keeping the sales tax higher and eliminating the mortgage tax deduction, or some other combination of tax adjustments or budget cuts. Of all the issues before us, the budget and taxes are the most challenging.
As everyone begins to realize how quickly the session is passing, the pace is picking up dramatically. It is always interesting to watch the process as a sense of urgency enters. The bottom line is that the legislature is only required to pass a balanced budget before the session ends, and doing that takes most of the session to put the budget together.
I have coffees scheduled for Feb. 23. Sen. Jay Scott Emler expects to join me at the Goessel City Building at 10:30 a.m. As always, it is an honor to serve as your representative in Topeka. Please call or email with concerns.


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Is Google Going Too Far In Latest Advertising Bans?
from the a-little-explanation-would-be-nice deptWe've been talking a bit about some of the communications problem Google seems to have at times, often not doing a very good job communicating with the public on things that may impact them greatly. Here's yet another example, sent in by Ryan, who notes that many people have recently been kicked out of Google's AdWord program with no recourse or explanation.
Now, it seems pretty clear that Google is trying to block "bad" advertisers who are somehow lying or cheating the system -- and that's a good thing. But these sweeping bans seem to be catching plenty of legitimate advertisers, and even more frustrating than the "ban" itself is the fact that as many times as you attempt to get them to explain why you were banned or ask for your case to be reconsidered, the company's response is, effectively, to tell people: "You were banned for being bad, and you will never advertise with us again. Goodbye." While I'm sure plenty of the banned accounts were banned for nefarious activity, it seems ridiculous to do a permanent and total ban with no explanation whatsoever. Google has been known to do this before (certainly many folks who use AdSense have received similar notices with the same lack of info or recourse). It's just a shame, because it's the sort of thing that Google could do right, and seems to have chosen not to.
Filed Under: ads, bans, communications
Companies: google


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9 April 2013 at 2.59pm | 30 Comments
Booking dates
All the booking dates below open at 10am.
- Premium 2 Friends: 10 September 2013
- Premium 1 Friends: 11 September
- Supporting Friends: 12 September
- Friends of Covent Garden – Ballet: 24 September
- Friends of Covent Garden – Opera: 25 September
- Advance Booking Packages (Friends Booking): 17 September
- Advance Booking Packages (General Booking): 15 October
- General Booking: 22 October
View the Royal Opera House 2013-14 Winter Season Seating Plan (PDF 1 MB)
Use the links above to see a full list of events that can be booked on that particular day. This can be useful when adding a number of tickets from different productions to your basket.
Le nozze di Figaro
Dir: David McVicar
16 September – 15 May
Revolution is in the air in David McVicar's production of Mozart's glorious comedy.
Dir: Francesca Zambello
16 December – 9 January
Spanish heat and gypsy passion are brought to the stage in Francesca Zambello's vivid production of Bizet's opera.
Dir: Laurent Pelly
14 January – 4 February
A young girl longing for love is corrupted by wealth and luxury in Massenet's classic opera, directed by Laurent Pelly.
Don Giovanni NEW
Dir: Kasper Holten
1 – 24 February; Live in cinemas 12 February
Director of Opera Kasper Holten presents a new production of Mozart's sublime tragicomedy.
La Fille du régiment
Dir: Laurent Pelly
3 – 18 March
Donizetti's entertaining opera marches onto the stage in Laurent Pelly's production. Irrepressible humour and catchy melodies make for a delightful evening.
King Priam (Linbury Studio Theatre)
Dir: James Conway
13 - 22 February
Michael Tippett's magnificent King Priam is brought to the ROH in one of English Touring Opera's most ambitious productions to date.
Paul Bunyan (Linbury Studio Theatre)
Dir: Liam Steel
17 - 21 February
The English Touring Opera also present Benjamin Britten's brilliantly inventive Paul Bunyan, which draws on an American folktale about a lumberjack giant.
Dir: Andrei Serban
9 September – 10 March
Andrei Serban's staging of Puccini's final opera is a glorious pageant of rich colour, dance and drama.
The Nutcracker
4 December – 16 January; Live in cinema 12 December
A young girl's enchanted present leads her on a wonderful adventure in this classic ballet, accompanied by Tchaikovsky's glittering score.
The Wind in the Willows
11 December - 1 February at The Duchess Theatre
The Duchess Theatre in the West End hosts choreographer and director Will Tuckett's hugely popular and critically acclaimed Christmas production of Kenneth Grahame's classic tale.
17 December – 7 January
George Balanchine's evocation of the sparkle of emeralds, rubies and diamonds is a ballet gem in its own right.
London International Mime Festival (Linbury Studio Theatre)
9 – 11 January; 30 – 31 January
The annual celebration of visual theatre returns, with spectacular, cutting-edge and inspiring performances.
Hansel and Gretel (Linbury Studio Theatre)
Artist-in-Residence Liam Scarlett's first full-length work for The Royal Ballet – a dark, adult take on a classic fairytale.
18 January – 10 February; Live in cinema 27 January
The greatest of all Romantic ballets – Marius Petipa's classic work is a dramatic story of betrayal, supernatural spirits and love that transcends death.
Rhapsody / The Art of Fugue / Gloria
7 – 15 February
A celebration of three defining choreographers of The Royal Ballet: Frederick Ashton, Kenneth MacMillan and Wayne McGregor.
Ballet Black (Ballet Black, Linbury Studio Theatre)
26 February – 4 March
Cassa Pancho's company of black and Asian classically trained dancers returns to the Linbury Studio Theatre with a dynamic new programme.
Young British Dancer of the Year Final 2014 (Linbury Studio Theatre)
8 March
A celebration of the best of British emerging dance talent – 16 finalists vie for the hotly contested award.
To accompany the productions on-stage, Royal Opera House Restaurants are providing menus tailored specially for each production. Find out more closer to the time in our Restaurants and Bars section.


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Mplus Discussion
Missing Data Modeling
posted on Thursday, November 12, 2009 - 5:04 am
Dear Dr Muthen,
I am doing a basic latent class analysis of cross-sectional data. Sample size is 2000. Some independent variables have missing values, but none of the indicators of latent class is missing.
In the section of variable, I typed: "Missing are all (-9999); and in the analysis section, I typed "type=mixture." I run a couple models. Each turns out has different number of observations since I use different sets of independent variable. The user guidebook said: The default is to estimate the model under missing data theory using all available data. I have the following questions.
1)Were all available data, including variables with missing values, utilized if I put command in the above-mentioned way? I would like to have all of the available information used.
2)My models have different number of observations, all of which are smaller than my sample size. Should I report both number of observations and sample size in my tables?
3)The reason I run different models is to see if the coefficient of a specific variable is stable. But is it appropriate to report models with different numbers of observation (the same data set) in one paper? Or should I drop all of the cases with missing variables to fix the number of observation?
Thank you in advance.
Linda K. Muthen
posted on Thursday, November 12, 2009 - 9:06 am
You can report that results for different sample sizes or you can bring the covariates into the model and treat them as dependent variables. This is done by mentioning their variances in the MODEL command. This is similar to multiple imputation.
Oliver Arranz-Becker
posted on Monday, February 22, 2010 - 6:24 am
Dear Dres Muth�n,
I have a question about proper treatment of missingness due to panel attrition. I have a 2-variable-2-wave cross-lagged model with repeated measures for X and Y, i.e. X1 and Y1 (at t1) are associated with both X2 and Y2 (at t2). Some missingness at t2 is due to panel attrition. My questions:
1. Is it sensible to use a "FIML" approach with panel data?
2. What N am I supposed to report? Giving the full sample size reported by Mplus looks weird because it would suggest that there is no panel attrition.
I would appreciate any suggestions.
Thank you in advance,
Oliver Arr�nz Becker
Linda K. Muthen
posted on Monday, February 22, 2010 - 8:40 am
1. Yes.
2. Report the full sample size along with the fact that you are using FIML. Also give the coverage.
Oliver Arranz-Becker
posted on Wednesday, February 24, 2010 - 2:11 am
Thanks a lot for your advice to the last questions.
In the same paper, we also present a discrete time event history analysis (with a dichotomous event indicator as DV and several covariates). On the basis of other postings on this board, we think there are two options to avoid listwise deletion of missings: 1. probit model (WLS) including predictors by mentioning their variances, or 2. estimate the model via ML with Monte Carlo integration. My questions:
1. Which of the two methods would you recommend (if you know of any references, that would be great)?
2. Is the second approach essentially a FIML estimation? Or how are we supposed to describe the method in the paper?
3. Can you provide any reference as to why Monte Carlo integration is necessary in this case?
Thank you so much for your help,
best regards,
O. Arr�nz Becker
Linda K. Muthen
posted on Wednesday, February 24, 2010 - 10:17 am
You must use maximum likelihood to estimate a discrete-time survival model. This means that the missing data estimation is done using FIML. If you don't want observations with missing values on observed exogenous variables removed from the analysis, you can mention the variances in the MODEL command. They will then be treated as dependent variables and distributional assumptions will be made about them. Monte Carlo integration is required when there are missing data on mediators.
Oliver Arranz-Becker
posted on Thursday, February 25, 2010 - 4:59 am
I guess I misstated my previous question. We do not use a latent variable framework for the discrete-time event history analysis but rather have just one event indicator (i.e., there are only 2 timepoints, covariates are measured at t1, event at t2). So the analysis is essentially a path analysis with a dichotomous outcome.
What is the difference between an FIML and a WLS estimator in this case, and which one is preferable? How are missings treated in WLS if exogenous variables are mentioned in the model command?
Thank you so much for your support,
best regards,
O. Arr�nz Becker
Linda K. Muthen
posted on Thursday, February 25, 2010 - 10:14 am
With weighted least squares, missing data are handled using pairwise present information. Given the choice, I would use FIML.
Melanie Wall
posted on Monday, August 30, 2010 - 6:27 am
There appears to be a difference in the way that Mplus 6 reads in "Number of observations" compared to Mplus 5 with regard to missing values. I have found that in Mplus 6 my "Number of observations" was reduced to only those individuals who had complete "x-variables" while in Mplus 5, it gives the total n in the dataset regardless of what actual model is being fit. It appears that whereas before these observations with missing x-variables would be included in the "Number of missing data patterns", now those individuals simply are not included at all in analyses.
Hence for a basic SEM, I am getting different results whether I use Mplus 5 or Mplus 6 presumably because of this difference in the way missing data are handled. Is there a way in Mplus 6 to have individuals with missing x-variables included in FIML without resorting to multiple imputation?
Linda K. Muthen
posted on Monday, August 30, 2010 - 6:37 am
If you specify the variances of the covariates in the MODEL command, you will obtain the Version 5 results. In Version 6, with all continuous outcomes and maximum likelihood estimation, we started estimating the model conditioned on the covariates to be in line with the rest of Mplus and regular regression. It is the case that with all continuous outcomes, maximum likelihood, and no missing data estimating the model conditioned on x or jointly obtains the same results.
Melanie Wall
posted on Monday, August 30, 2010 - 6:58 am
Hi Linda
So I did as you suggested and "specified the variances of the covariates in the MODEL command" simply by adding another line listing them with a semicolon, e.g.
x1 x2 x3;
I see this change in the default from Mplus 5 to Mplus 6 as a substantial change in the handling of missing data. Basically, if I understand correctly, now by default missings on x-variables are handled with listwise deletion, while missings on y-varaibles are handled with FIML. Previously all variables were handled with FIML. Perhaps I missed it, but it might be useful to make this change more prominent on your UPDATES in Mplus 6 page.
Linda K. Muthen
posted on Monday, August 30, 2010 - 7:49 am
The handling of missing data has not changed. Missing data theory applies to dependent variables only. It has never applied to independent variables. Prior to Version 6 for models with all continuous variables and maximum likelihood estimation, all variables were treated as dependent variables for the reason stated above.
posted on Wednesday, October 24, 2012 - 5:41 pm
I have a dataset from a survey I conducted with missing data (N=610). I ran a CFA with 12 binary variables and the WLSMV estimator.
f1 by y1 y2 y3;
f2 by y4 y5 y6 y7 y8 y9;
f3 by y10 y11 y12;
My resulting N for the CFA was 572.
I followed up my CFA with the following:
f1 by y1 y2 y3;
f2 by y4 y5 y6 y7 y8 y9;
f3 by y10 y11 y12;
f1 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f2 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f3 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
which results in an N=418 because there are 192 cases with missing on x-variables. However, I receive an error that says:
When I re-run it like this (per advice I received):
f1 by y1 y2 y3;
f2 by y4 y5 y6 y7 y8 y9;
f3 by y10 y11 y12;
f1 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f2 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f3 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
x1 x2 x3 x4 x5 x6 x7 x8 x9;
my N=610.
This model runs successfully and has good model fit. However, I'm not sure I can justify presenting a CFA with 572 cases followed by a structural model with 610 cases - or can I?
Is the latter method appropriate/ justifiable? I am new to SEM and Mplus so any thoughts on this matter would be greatly appreciated.
Thank you.
Linda K. Muthen
posted on Thursday, October 25, 2012 - 9:52 am
I would use 572 for both analyses. This would eliminate the observations with missing on the y's and having data for only the x's.
posted on Thursday, October 25, 2012 - 10:22 am
Hi Dr. Muthen,
That would be fantastic. I'm not at a computer with Mplus right now but would the syntax be:
f1 by y1 y2 y3;
f2 by y4 y5 y6 y7 y8 y9;
f3 by y10 y11 y12;
f1 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f2 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f3 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
y1 y2 y3 y4 y5 y6 y7 y8 y9 y10 y11 y12;
Thank you.
Linda K. Muthen
posted on Thursday, October 25, 2012 - 2:12 pm
You would need to use the USEOBSERVATIONS option to exclude observations with missing on all of the y's and then use the following:
f1 by y1 y2 y3;
f2 by y4 y5 y6 y7 y8 y9;
f3 by y10 y11 y12;
f1 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f2 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
f3 on x1 x2 x3 x4 x5 x6 x7 x8 x9;
x1 x2 x3 x4 x5 x6 x7 x8 x9;
John Perry
posted on Friday, April 11, 2014 - 4:06 am
Dear Drs Muthen,
hopefully I am missing something obvious here... I have a sample with 342 participants and no missing data. However, in a simple ML SEM, I am getting 171 observations in the output (exactly half). I'm really not sure what I'm doing wrong here because I've not come across this before.
Bengt O. Muthen
posted on Friday, April 11, 2014 - 6:12 am
Probably some data reading issue. Please send data, input, output, and license number to Support.
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2005-2013 Robert Martin
Bob Martin was appointed to the Board of Regents in 2005 by Governor Murkowski. Regent Martin was born in Kake and raised in Kake and Juneau. He graduated from the University of Alaska with a degree in electrical engineering. He currently works at Goldbelt Corporation. Regent Martin served as the director of the Southeast Region for the Alaska Department of Transportation and Public Facilities, as regional roads engineer for the Alaska Bureau of Indian Affairs, and spent 14 years in the utility industry, serving as general managers of Tlingit Haida REA and Chugach Electric. He is the former chairman of the Alaska Energy Authority and Goldbelt board of directors.


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Fred Hutch has a long history of saving lives through high quality research. Our work—highlighted here—has touched millions of people. Dr. Julie Overbaugh (pictured) studies the mechanisms of viral pathogenesis.
Research Highlights
Fred Hutch has a long history of saving lives through high quality research. Our work—highlighted here—has touched millions of people. Dr. Julie Overbaugh (pictured) studies the mechanisms of viral pathogenesis.
Fred Hutch opened its doors in 1975, but its history began nearly 20 years earlier with the vision of Seattle surgeon Dr. William Hutchinson (pictured at center), brother of baseball hero Fred Hutchinson. Dr. Hutchinson dreamed of providing funds and laboratory space to physicians pursuing research, including Dr. E. Donnall Thomas, who was developing a novel blood cancer therapy known as bone marrow transplantation. With critical help from Washington State's legendary U.S. Senator Warren Magnuson and the Seattle community, Fred Hutch opened its first home in Seattle's First Hill neighborhood.
The Long-Term Follow-Up Program was launched in 1976 to provide life-long monitoring and care of patients following a bone marrow or stem cell transplant. The Hutch researchers work with a patient's personal doctor to collect data decades after treatment. This information allows the Hutch researchers to learn about the long-term effects of transplant procedures and determine the best preventive care or treatment for current and future patients. The program continues today, and in 2011 the Center welcomed transplant patients in their fifth year of survival or later to the program's fifth Legacy of Life reunion (pictured).
Fred Hutch houses the nation's oldest and largest program devoted to understanding the causes of cancer and how to prevent it. With the founding of the Cancer Prevention Research Program in 1983, our researchers have gone on to delve into the links between cancers and numerous possible triggers, ranging from genetic and biological factors to diet, exercise and other lifestyle choices.
Work by our clinical researchers in 1986 resulted in today's "gold standard" treatment for graft vs. host disease (GVHD)—a complication that occurs in some patients who have received transplants using donor cells. In GVHD, the transplanted cells recognize the patient's own cells as "foreign" and mount an attack against them, causing a range of symptoms and potentially serious damage to body organs. Building upon years of testing two drugs separately, our researchers found that a combination of two drugs—methotrexate and cyclosporine—provides effective GVHD protection. This groundbreaking work continues today. Pictured is a still from a video on how physicians can assess GVHD.
Fred Hutch researchers played a pivotal role in developing bone marrow transplantation, a procedure that has been conducted more than one million times worldwide and saved hundreds of thousands of lives. Led by Dr. E. Donnall Thomas (1920-2012) (pictured), Fred Hutch researchers transformed bone marrow transplantation into an established treatment for leukemia and other blood cancers. This work earned Thomas the 1990 Nobel Prize in physiology or medicine, and the procedure now ranks among the greatest success stories in cancer treatment.
Our investigators in 1992 became the first to show that laboratory-produced molecules known as monoclonal antibodies can deliver radiation to leukemia- and lymphoma-related tumors. This breakthrough, part of a broader class of treatments known as immunotherapy, has provided a direct attack on tumors, thus sparing healthy cells and minimizing harmful side effects of treatment. Discoveries by Center researchers were instrumental in the development of antibody-based treatments that have gone on to become widely used anticancer drugs, including Rituxan™ for non-Hodgkin's lymphomas and Bexxar™ for follicular lymphomas.
The rigors of traditional bone-marrow or stem-cell transplants can pose problems for older blood-cancer patients or younger patients with medical troubles. In hopes of extending the potential benefits of this treatment to a broader population, our researchers, led by Dr. Rainer Storb, began clinical trials in 1998 to test a lower-intensity approach. Unlike conventional transplants, this treatment—called the non-myeloablative stem-cell transplant or "mini" transplant—does not wipe out the patient's bone marrow and involves minimal doses of radiation, thereby reducing toxic side effects. By 2001 our researchers had concluded that this radically different transplantation method is, in fact, a viable treatment option for certain patients.
In 2001 Dr. Lee Hartwell received the Nobel Prize in physiology or medicine for using brewer's yeast to uncover the genetic mechanisms of cell division. By identifying "checkpoint" genes that determine whether a cell is dividing normally, the former director and president emeritus of Fred Hutch provided important clues to cancer, which arises from abnormal, uncontrolled cell growth. Hartwell's discoveries have led him and other scientists to explore ways to stop abnormal cells from dividing. This work will lead to new and better ways to prevent, diagnose and treat cancer.
For us humans, growing older is the greatest cancer risk factor. A landmark 2003 study by the Center's Dr. Daniel Gottschling and colleagues may help to explain why. Using yeast as a model organism, our researchers discovered that when yeast cells hit the equivalent of late-middle age, they experience a surge in genetic instability. These findings suggested this simple, single-celled organism may be an ideal model for understanding the complexities of age-related cancer development in humans.
Photo by Masur
In 2004 Dr. Linda Buck received the Nobel Prize in physiology or medicine for her groundbreaking work on odorant receptors and the organization of the olfactory system — the network responsible for our sense of smell. The work is the first to define one of our sensory systems in the most detailed manner possible by defining the genes and proteins that control this remarkably complex response.
The Hutch's research into cancer survival has helped thousands of patients enjoy a high quality of life well after their treatments have ended. Our Survivorship Program, launched in 2006, researches a range of topics, from the long-term effects of cancer treatment on the cardiovascular system to examining the factors that contribute to emotional health. Research is led by Dr. Scott Baker and Dr. Karen Syrjala (pictured). In addition to research, our Survivorship Program also offers a variety of resources for active living, healthy eating and social engagement.
Researchers at the Hutch and Seattle Children's found in a 2007 study that a scorpion-derived molecule can help illuminate cancer cells in brain tissue, giving surgeons a better chance of removing harmful tumors without injuring surrounding healthy tissue. The Center's Dr. Jim Olson developed the "tumor paint"—a fluorescent molecular beacon known as Chlorotoxin:Cy5.5. This innovation is important because surgery is a primary cancer therapy, yet, despite other advances in surgical tools, distinguishing where tumors end and healthy tissue begins has remained a challenge.
Our researchers, including Dr. Stanley Riddell (pictured), have earned worldwide renown for developing successful treatments that harness the immune system to fight cancer, much as it naturally eliminates everyday infections like the common cold. This revolutionary field, called immunotherapy, has been found to yield effective cancer therapies with far fewer side effects than conventional drugs, radiation or surgery. In the early 1990s our researchers became the first to show that rare disease-fighting cells, known as T cells, can be isolated, multiplied in large quantities, and infused back into patients to treat viral diseases. A major breakthrough occurred in 2008 when the Center reported the first known successful use of a melanoma patient's own cloned T cells as the sole therapy to put his advanced solid-tumor cancer into long-term remission.
Pancreatic cancer is a particularly deadly because it is typically detected at a late stage and is especially resistant to chemotherapy. Dr. Sunil Hingorani, a recognized leader in pancreatic cancer research, identified a method of using a key enzyme to break through the barrier that pancreatic tumors form, allowing for the delivery of chemotherapy. The discovery was based on a mouse model for studying pancreatic cancer—a research tool that Dr. Hingorani himself developed. The treatment is currently in clinical trials.


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