text:
Pedestrian Dialogue in GTA IV
|This article needs to be re-arranged or reorganised to make it clearer and easier to read.
- 1 Public Services
- 2 Services
- 3 Civilians
- 3.1 All
- 3.2 Holland Pedestrian
- 3.3 Bikers
- 3.4 Preacher
- 3.5 British Pedestrians
- 3.6 Russian Pedestrians
- 3.7 Brazilian Pedestrians
- 3.8 Drugged Brazilian Pedestrians
- 3.9 Homeless
- 3.10 In a vehicle
- 3.11 In a conversation
- 3.12 Girls
- 4 Gangs
- 5 Authority
- 7 Perseus Guard
- 8 External links
Public Services
Taxi Drivers
When Damaging Their Vehicles
- Stupid Malaka!
- What the fuck are you doing to my car?!
- What is this shit, my car!
When They're After The Player
- Holokrypa!
- I'll beat your ass!
- Ah shit!
- Dana?
- You're gonna die!
- You think this is gonna get fucking fancy?
- Fuck off!
- Miyeto Yelezes!
- Miti Moa siverie!
- You got a real deal now!
- I'm gonna kill you!
- Don't make me beat your ass!
- Wanna fight me or fuck me? bring it!
- Ay, freak o!
- Ah! So angry!
- You think dis is gonna be easy, don't you?
- Wipe you're ass!
- I dont take your shit anymore!
- Don't fake the funk!
- Is this all you got?
- I'm too fast for you!
- Where you want it? Neck? Right...
- To Hades with you, Malaka!
- May Poseidon swallow you whole!
- You think I'm a fucking pansy?!
When The Player Wastes Their Time
- Get a move on!
- Move it
- Are you in? Move that piece of shit!
- Where are you waiting for?... Christmas?
When Running From Officers
- You'll never take me, officer!
- Fuck the hell off.
- Burgers! 40 percent Meat!
- Why you always pick out the "Poenzoz"?
- BURGERS! Fresh yesterday!
- Who wants one? They're not great when they're cooked!
- Hey! Delicious beef patty!
- The best in Liberty City!
- Burgers!
- Come on! I washed my hands!
- Who wants my meat?
- Come on! They're not gonna throw themselves up!
- Will somebody fucking buy something?
- You motherfuckers think you're too good for these?
- I killed these cows myself!
- Only 40% face meat, guaranteed!
- Come and bite this plump chihuahua meat!
- My dogs is long and hot!
- Slurp down my hot nuts!
- Only 12 nuts for 7!
- Hot nuts, baby!
- Wanna feel shitty? Buy a newspaper!
- President said something stupid, read all about it!
- All of the news, only one day after the internet.
- Hot dogs, free mustard!
- Some of these are fresh, FRESH!
- Who wants my hot chihuahua meat?
- Put this dog in your mouth!
When Harassed
- Watch yourself
- That hurt motherfucker!
- I'm pumped!
- Get the fuck off, bitch!
When Angry
- You're fast for a nobody eh?
- Let's do this bitch!
- You want this?
- Tell me when you're ready!
- Ever seen moves like this?
When Mean
- Vètecho porro!
- Bottilala pingla!
Cluckin' Bell Male Clerk
- Yo! Welcome to Cluckin' Bell! Can I getcha a bucket of chicken?
Burger Shot Male Clerk
- Welcome to Burger Shot motherfucker...!
- You got some iron stomach, dawg!
- Enjoy, motherfucker..!
When Witnessing An Event
- They are not going to believe this shit!
- Oh, Jesus!
- Yo, that's freakin' insane, man!
- Finally, some action in this town!
- Not good, not good, not good!
- Damn, son! That's straight out of a movie!
- I wish I felt sorry, but I don't.
- Please don't be dead. Please don't be dead...
- Aw, this is gonna be gross!
- I'm not the only one seeing this shit, right?
- No freakin' way!
- Oh, that's gotta hurt!
- Wow!
- I wanna move back to San Andreas! Oh, man...
- Christ! What the hell?
- Are we gonna die?
- Crap! What was that?
- Someone pinch me, 'cause I wanna wake up!
- That's the crack, my dude.
- Did anybody see that?
- Shit a brick! What was that?
- Call the media!
- I'm never getting stoned again!
When In A Collision
- Fuck, fuck, fuck-fuck-fuck!
- Give me my money now!
- You better have insurance!
- What is this shit?! My car!
- NO!! This is my mother's car!
- Oh, no! This my first figgin' car!
- How the hell did you hit my car?!
- My car!
- You stupid freak!
- What's happening? Like...what's happening?
- What d'you think this is, bumper cars or something?
- This ain't no fuckin bumpa' cars motherfucker!
- D motherfucker, d-d, drive!
Holland Pedestrian
In The Street
- Yo, this your boy from Bohan, what's poppin'?
- Yo man! I take damn people over streets son!
- What the fuck you want?
- Pull back you wierdo!
- Get outta ma face son!
- Motherfucka!
- You better pull back before I fuck some butts!
- Fuck outta here man!
- YO, fuck!
- Pull back watch ya yo!
- Dats Russian ass daddy!
- Yo what you do here?
When Attacking The Player
- I'm gonna piss in ya mouth!
- Motherfucking damn son!
- You're motherfucking face is not gonna roll me!
- I'll drop you son! South Bohan style!
In The Street
- Come on! Fight me!
- Pardon me fuckface!
- Fight me, my dick is getting hard!
During Rant
- Listen people! You ain't goin' to Hell, you're living in it!
- Are we truly living in a world of pain?
- You're all going to hell!
- You can let me punish you or live and wait for hellfire!
British Pedestrians
In The Street
- Watch it you berk!
- I'm gonna beat you arsehole!
- Are you takin' the piss?
Russian Pedestrians
When In Traffic
- Move or I'll fucking break something!
- I'll rip your heart out!
- There's always so much traffic in this fucking city!
Brazilian Pedestrians
When Run Into
-- (Portuguese mixed with english)
- Vai pra casa do caralho! (Go to the dick's house!)
- Vai tomar no teu cú, porra! (Fuck you, goddamn!)
- Não enche meu saco não asshole! (Don't piss me off asshole!) --
- Tá máluco?! Tá maluco?! (Are you crazy?! Are you crazy?!)
- Tá máluco meu irmão?! Vou te meter porrada amigo! (Are you crazy bro?! I'm gonna beat you up homie!)
- This is the best part of my day!
- I am in fucking charge right now!
- Vai vai meu irmão, get a fucking move on! (C'mon bro, get a fucking move on) --
- Caralho! (Dick!)
- Puta que pariu! (Holy Bitch!)
- Porra! (Goddamn!)
- What are you doing? Move it!
- Stay in the lixo, puto! (Stay in the trash, bitch!)
- Filho da puta! (Motherfucker)
- Vai se fuder! (Fuck you!)
- You pick the wrong malandro to fuck with! (You pick the wrong homie to fuck with!) --
When Damaging Their Vehicles
- Filho da puta! (Motherfucker!)
- No! I just fucking stole this fucking car!
- No! you're dead, asshole!
Drugged Brazilian Pedestrians
- I spend all my grana in crack. (I spend all my cash in crack.) --
- Do you know where i can find some grana? (Do you know where i can find some cash?) --
In the streets
- Wanker!
- Idiot!
- Ass-pendeck.
- Pinhead Dipshit!
- Stop touching me!
- This is terrorism at all!
- Too many gorillas!
- I don't have any bananas!
- This isn't pinball!
- Flick!
- Murder!
- More drama for yo' mama!
- Ghhmmp! That hurt.
- That slut ruined my life.
- I'll sue your ass!
- Watch it!
- We're being invaded!
- What the fuck is going on?
- The aliens are getting bold with their attacks!
- Psst, Reptillians are taking over, pass it on!
- Mommy, I'm so sorry for killing you, Mommy!
- Can't you see I'm urinating here?
- Oh no! They done killed another true seeker!
- Robot man juice!
- Call air support!
- You see? Reptillian Death-Ray! Gotta be!
- Ya'll aliens only want my sperm!
- Cheesy vaginas!
- I just need one more fix.
- Fuck, where am I?
- This is the apocalypse!
- It's the Illuminati!
- Nothing in my teacup!
- Nothing in my coffee, nothing in my coffee!
- Too scary for words!
- I'll see you and the cause shall strip you naked.
- I see you and I shall see you nude.
- No more!
- I got nothing, I got nothing!
- The cause will skin you alive!
- There's no time for this.
- You got the wrong man!
In a vehicle
- That thing is collecting dust!
- You're growing molds up there.
- Hurry up, my chickens are pink.
- You're not making any friends with me!
- Slow wheels make for the devil!
- My dime, my car!
- Theres a stain on the dashboard.
In a conversation
- You need psychatric help.
- When they take your clothes, you can't even eat pancakes.
- Hey, my brother the cop, sometimes comes by with cookies!
- I've got errands to run. Goodbye until the next one time.
During A Fight
- You'll be nice and cool, soon!
- Hoho! Asswiping time!
- I'm in a fuckin' zone!
- Yeah! Come on shitpunky!
- I'm gonna hang you up!
- Well! Fuck all squared!
- Hey lunkhead! You ready, eh?
- Yeah! I'm a pissnick!
- I'll eat you alive toadrag!
- You ain't stealing no more sperm from me, alien!
- That's it, mommy, I'm whooping you back to the grave!
- It's time I stood up to you reptillians!
- You're gonna be laying my eggs!
- I'll Da Nang you good!
- That ass of yours is too big!
- The cause will strip you naked!
- He'll keep coming back!
- It's bodycount time!
- Theres more stuff coming!
- I'm bulemic, do you have anything greasy? (when speaking to vendor)
- Hey Schronda!
- Hey there!
When bumped into
- Did you just try to grab my ass?
- Eww, that guy just touched me!
- Say you're sorry!
- Watch where you're going, dillweed!
- Hey, I'm tweaking!
- Oh my God, that was so rude!
- Ugh, I hate tourists!
- You can't afford me!
Under attack
- I'm not a fighter!
- You can't hit me, I'm a girl!
- Leave me alone you fucking psycho!
- Go find another girl to hit!
- Help! Help! Heeellllp!
- Oh my God, I think he's trying to kill me!
- Tell me this isn't happening!
- Okay, fighting and fasting doesn't mix!
- Get away from me you ugly asshole!
- Somebody help, this guy's trying to hit me!
- Nooooo!
- I only let other girls hit me!
- You're insane!
- Please don't kill me!
- He's gonna shoot!
- Ow, I'll never model again!
- Oh my leg!
When stealing their car
- Please, I'm a model!
- Actually, you can have it, it's my boyfriend's!
When In Firefights
- Come on give me some cover.
- Take cover.
- Take some fucking cover
- Your a pain in the balls my friend.
- I got this Son of a Bitch.
- You want to go to war.
- Watch out this fucker is crazy.
- Take a look around we got you surrounded.
- I got this fucking Pollock.
- Get Down!
- Ain't no way out of this you fucking son of a bitch.
- I got you punk.
- Hey dipshit no where else to go.
- We got you surrounded asshole.
- Ready to die Bitch?
- I've had enough of you.
- Look around we got you surrounded Ahaha.
- There's no to go motherfucker.
- Your a pain in my ass.
- Take a look around buddy we got you.
- You asked for this.
- I live for this shit.
- Time to pay the piper.
When in a near death state
- Please don't kill me.
- Don't kill me man I got kids.
- I hurt my knee man.
- Why would a guy like you shoot me again.
Russian Mafia
When in a firefight with the player
- Hey asshole we got you!
- Hey man no place to go.
- Hey asshole your surrounded no where else to go.
- Now you give up because you are fucked.
- Gonna eat you alive!
- Let us end this like gentlemen yes?
- Yeah face me cowboy!
- They call this you are fucked.
- Goodbye to you.
- Die you fucking bastard!
- Take cover!
- This ends here.
- Head to Cover!
- Here I come you Whore.
- This one is for the old country.
- You are surrounded.
- I have them.
- Now is your time!
- Cover me you useless smucks!
- Eat hard Metal.
Korean Mob
- Look around your fucked now asshole!
- Try this on for size.
- Try again you fucking pussy.
- There's no way out motherfucker!
- Take cover.
- Your making a big mistake.
- Its been fun but the party is over.
North Holland Hustlers
- Drop this fool.
- Take that motherfucker!
- I got a clean shot.
- Let's move in Fam.
- Damn son take cover.
- Got you now.
- Fuck this clown time to murk his ass.
- You finished gangsta its a wrap.
- Seize the day brothers lets russ him.
- It on and popping now.
- Play it safe take cover.
- Man don't be stupid take cover.
- Hommie down my nigga.
Spanish Lords
- Give me a smile motherfucker.
- I'ma show you who has cojones.
- I have a shot.
- You surrounded yo.
- If I knock your teeth out will you give me a blowjob?
- Cabrone!
- Fucking Cabron.
- Your mine amigo.
- HAHA we have you trapped.
- I'm doing you a favor you ugly bastard.
- Your surrounded mamaguevo.
- why are you trying to push all into me motherfucker?
- Hey man over here pendejoe.
- Get down!Get down!
- Fuck you, mamaguevo!
- This is the end of the line asshole.
- Let's waste this punk man.
- He's shooting! Hide! Hide!
- He's going down.
- Now stay out of trouble.
- Do you want me to arrest you?
- You know I love to beat civilians.
- Hey asshole, you like prison food.
- I can picture you in a dark cell, what do ya' say?
- last time you do that is the tang.
- Hey stupid, You drunk?
Stuck in Traffic
- Hurry up, I just ate at Cluckin' Bell and need to get to a bathroom.
- Oh, a donut? Make it large.
During Chase
- Police car mic: Hey where are you going?!.....hello?!
- Police car mic: Stay where you are, LCPD!
- Police car mic: Don't make me come after you!
- Police car mic: LCPD, son! Don't you run, now!
- Police car mic: LCPD people, get off the street!
- Police car mic: You're trying my patience. Pull over.
- Police car mic: I'm that badass nigga' that yo' mamma' warned you about!
- Police car mic: I'm not fucking kidding, asshole!
- Police car mic: This is your final warning! Pull over.
- Police car mic: Pull over, or I'll be very mad.
- Police car mic: Get off the street everyone!
- Police car mic: Clear the streets!
- Police car mic: Pull over you maniac!
- Police car mic: Stop the car and turn the engine off!
- Police car mic: We've got you surrounded!
- This the LCPD! One move and you are a dead man, you hear?
- I need permission to blow his head off!
- I have confirmation on chicken shit.
- Hello, uh... LPCD! Right?
- Freeze! This is the LCPD!
- LCPD! Get on the ground! Place your hands behind your head!
- Do you think you can run from a chopper?
- One squeeze, and you're wearing your balls for earrings.
- Guess who's gonna get shot in the face?
- Fuck! You're gonna make me run, aren't you?
- That's right, son! You gettin' dropped!
- I will pursue on foot!
- Pursuing on foot!
- Suspect fleeing on foot!
- I have a visual on the asshole.
- Everyone hit the deck!
- Everybody eat dirt!
- I'm gonna shoot!
- I'll shoot your tits off!
- You're dead, buck-o!
- Lay down, cabron!
- You're mine, asswipe!
- You're surrounded! Right here, right now!
- You're dead, and you don't even know it yet.
- I'm still gonna get ya!
- You don't think you're going to escape from a whole group of cops, do you?
- You sorry son of a bitch!
- I smell the stink of guilt.
- Would you come the hell back!?
- This ends now!
- Everyone get down and stay down until I say it's okay to get up.
- Charge!
- I'll shit in your mouth
- Get out of the car now!
- You can run, but you can't hide!
- I've got a head-shot!
- ¡Oye puta, te veo!
- Human waste, dead ahead!
- This is the LCPD, dont move!
- Where you think ya gonna go, huh?
- Shit, why do they have to run?
- What is it with these people, escaping on foot all the time?
- Get down numb-nuts!
- I could get that shit stain myself
- I got ya now dickweed!
- Cover my ass!
- You're dead, fucko!
- Everyone eat dirt!
- Requesting NOOSE Team! (4+ Wanted)
- Requesting NOOSE Team, now! (4+ Wanted)
- Call the NOOSE! (4+ Wanted)
During Arrest
- You know carrying a weapon in this town, is a felony!
- What are these, stolen credit cards huh?
- That's another to add to the list of your crimes!
- Man you try to fucking run son, and you'll be sorry!
- Shit, I'm out of Breath after what I saw, so don't pull nothing!
- Oh thought you could run from me huh?
- Nobody fucks with me and lives!
- If you run again, You're fucked!
- I Got you Babe!
- You just won an all-expenses paid trip to the slammer!
- I'm gonna get Sargent over this!
- They're gonna love you at lock-up!
- When we get back to the station, I'll gonna beat you with a phonebook!
- You'll have lots of time to reflect on this now!
- I hope you're ready for prison showers, idiot!
- Let's take a little trip downtown!
- You're coming with me!
- You're going downtown!
- You like getting in trouble or something?
- I oughta beat you for making me run like that.
- I told you there's no point of running. You're under arrest.
- Crime loses today.
- Ha, Thought you could outrun me?
- Enjoy getting cornholed in the slammer!
- You thought you could get away from me huh?
- You have the right to shut the fuck up!
Near death state
- I'm gonna be OK! I'm gonna be OK!
- Officer down! Officer down!
- Call the paramedics! I've been shot!
- Please tell my wife I love her.
- I don't wanna die!
When fighting player
- I need everyone to get down and stay down until I say it's okay to move.
- Put your hands in the air.
- I got you you Son of a bitch.
- Alright everyone try to remain calm.
- Everybody take cover.
- Please evacuate the area quick.
- Get down.
- You are not safe here.
- Everybody get down and stay calm.
When downed by player
- Call 911 I'm bleeding out here.
- Help me somebody help me.
- I'm bleeding out here call 911 and get help fast.
- I need help call for backup.
- I've been shot please call an Ambulance.
Perseus Guard
- I know you just were a problem.
- Aha! Just like jail!
- Goddamn bang!
- I'm gonna lay you out!
- Fuck outta here.
- Oh shit!
- You're gonna pay!
- I'll bust your fucking head!
- You're gonna get fucked up!
- Yo man, what the fuck you want?
- Get back, son!
- Use it, or drop that shit!


text:
2 Timothy 3:1516a
For this morning, let me draw your attention for the time we have in God's Word back to 2 Timothy chapter 3. Looking again at the passage which has been our focus for a number of weeks. Obviously in studying through 2 Timothy we have come across this passage, verses 15 to 17, in the context of the third chapter. The first week that we looked at it we discussed primarily its intent with regard to Paul writing Timothy, that is the primary significance of it in its context. And then feeling that one look at that text didn't really do justice to it, we took another week and examined the whole idea indicated in verse 16 of all Scripture being inspired by God because that is a tremendously impactful statement that goes way beyond any specific instruction Paul could give to Timothy. The fact that Scripture is inspired is of monumental consequence and so we dug a little more deeply into the matter of inspiration.
And as I was planning to kind of move on in 2 Timothy, I was rereading the epistle and I came back to this same section and in reading it I realized that there was one further tremendously important issue here that had not been addressed that I needed to deal with and that has to do with what I like to call the work of the Word...the work of the Word. We talked about the fact that it was inspired but we must also focus on its work. And you will notice in verse 15 that it says that the sacred writings are able to give you the wisdom that leads to salvation through faith which is in Christ Jesus. Initially the work of the Word is salvation. Then in verse 16, it is useful, that is inspired Scripture is useful, for teaching, for reproof, for correction and for training in righteousness with the idea that the end product may be a man of God adequate and equipped for every good work.
Now a simple reading of those verses indicates to us five elements of the work of the Word...salvation, teaching, reproof, correction, training and righteousness. Those are the things which the Word does, which the Scripture produces. They're not new to me, they're not new to most of you, they're new to perhaps some of you. And as I thought about it I thought, "Well, it's pretty basic but it's also pretty important." And let me say by way of general introduction that the distinguishing characteristic, I hope, of my own ministry and of Grace Community Church, is a very very strong commitment to the authority of the Word of God. We are definitely a church committed to God's Word. We endeavor to teach God's Word, to preach God's Word, to implement God's Word, to live God's Word, to proclaim God's Word, to exalt God's Word. It is the focal point of everything that we do. When God speaks, we listen.
I think so many times of Revelation 2 and 3, if you have ears to hear then hear what the Spirit says to the churches. So we have always been a church that listens to the Word of God, that is committed to the Word of God, that is submissive to the Word of God. And the focal point of our ministry has been the Scripture. There are many things that a church can do. There are many focuses. There are many sort of themes that a church can camp on. But for us for all these years it has been the Word of God. Our church, our personal lives are dominated by the Word of God. Week in and week out we teach the Bible. Here in the services we preach it expositorily, that is explaining its meaning. We go through Scripture after Scripture after Scripture. The reason for that is because of the work of the Word. Because we understand what it does, that's why we give it the main attention.
Let me just remind you of a very important promise with regard to this. Isaiah 55:10 and 11, you don't need to look it up, just listen. "For as the rain and the snow come down from heaven and do not return there without watering the earth and making it bare and sprout and furnishing seed to the sower and bread to the eater, so shall My Word be which goes forth from My mouth. It shall not return to Me empty or void, without accomplishing what I desire and without succeeding in the matter for which I send it."
In other words, God says when I send My Word it always does its work...it always does its work. It never comes back empty. Just like rain and snow produces what grows, My Word produces My will. The Bible is God's messenger. It accomplishes His will. It accomplishes His purpose. The Word of God is depicted in Psalm 147 as a swift messenger. It runs to do God's work. It runs to accomplish God's goals.
You might look just at Psalm 147 for a moment. There are several verses there that really are very vivid. Verse 15, "He sends forth His command to the earth," that's verse 15, "He sends forth His command to the earth, His Word runs very swiftly. He gives snow like wool. He scatters the frost like ashes. He casts forth His ice as fragments. Who can stand before His cold? He sends forth His Word and melts them. He causes His wind to blow and the waters to flow. He declares His words to Jacob, His statutes and His ordinances to Israel."
And here is this sort of intertwined analogy as God sends the cold and frost and the sun and all the natural elements to produce what He wants to produce, so He sends His Word. And the Word is analogous to that, it goes out to produce the ends that God has intended for it. That's a tremendous confidence that we have who teach the Word of God, who articulate the Word of God, to know that it always accomplishes what God wants it to do, never comes back empty, always produces, always produces, like rain and snow and all the other things that God sends with production in mind. The Word is productive. It is prolific and it accomplishes its purpose. Every word out of God's mouth is bread, it says in Deuteronomy 8:3. It feeds somebody. It nourishes somebody. It makes somebody grow. It accomplishes something.
And so we want to ask the question then, if it does accomplish something, what does it accomplish? What is the work of the Word? What is the purpose of the Word? And let's look at these five things, we'll look at two of them this morning, just briefly giving you what may for most of you be review and then the other three next Lord's day.
The first one is that the Word produces salvation. You'll notice that very familiar verse that we looked at in chapter 3 verse 15. It says that the sacred writings which are able to give you the wisdom that leads to salvation which comes, of course, through faith in Christ Jesus. The thing that he says there is the Word, the sacred writingsreferring to Scripture, have primarily in that particular verse reference to the Old Testament, but nonetheless Scripture produces salvation. Scripture produces salvation. It makes you wise unto salvation. It is the instrument of salvation. The practical implications of this are obvious.
Before we look at those though let's see if we can't reinforce that truth a little bit by looking namely at the testimony of Jesus Himself. Turn in your Bible to John's gospel. And in John's gospel we have the continual teaching of Jesus about the power of His word and the Word of God. But in chapter 5 and verse 24 we read this, the words of Jesus, "Truly truly I say to you, he who hears My Word and believes Him who sent Me has eternal life and does not come into judgment but has passed out of death into life." That is a tremendous verse. That is a verse that binds up the essence of the gospel. Believing in God, the God who sent Christ, and hearing the Word brings eternal life and delivers one from judgment, passing out of death into life.
And note, please, the key to it all verse 24, "He who hears My Word." The Word is the agency. The Word is that which begets new life. In John chapter 6, I draw your attention to a couple of verses toward the end of the chapter. And Jesus again teaching in this familiar section where He speaks on the bread of life, but in verse 63 He says, "It is the Spirit who gives life, the flesh profits nothing." Then this, "The words that I have spoken to you are Spirit and are life and if they haven't effected that in you," verse 64 implies, "that's because some of you don't believe." So, the Word mixed with faith produces life.
Chapter 12 of John, and there are other texts you could look at but these are highlights. Chapter 12 and verse 49, Jesus says, "I did not speak on My own initiative." Even Jesus operated under delegated authority and operated by speaking only that which was the Word of God. He said, "My Father Himself who sent Me has given Me commandment what to say and what to speak and I know that His commandment is eternal life, therefore the things I speak I speak just as the Father has told Me." And again Jesus is articulating the reality that the Word is that which produces eternal life...the Word brings life.
The sum of it all comes in that great watershed verse 31 of chapter 20 in John's gospel which really gives us the reason for the whole book...the whole gospel. "These have been written...these have been written," says John, "that you may believe that Jesus is the Christ the Son of God and that believing you may have life in His name." And again, eternal life comes by believing the written Word, the revealed Word, the Word of God. Scripture then is the source of that truth which brings salvation.
Look again further into the New Testament, the tenth chapter of Romans and we find that the Apostle Paul was committed to the same truth. In Romans chapter 10, a familiar verse, 17 says, "So faith comes from hearing and hearing by the Word of Christ." Or some manuscripts the Word of God, I think, preferably the Word of Christ, the New American has it that way. But the point is, one way or the other it's the Word of God or the Word of Christ which are one and the same that produces salvation. Faith comes by hearing and hearing by the Word of Christ. That's why you have to have preachers. That's why you have to have those who will go out and speak the truth. It says in verse 13, "Whoever will call on the name of the Lord will be saved." But how are they going to call on Him in whom they have not believed and how they going to believe in whom they have not heard and how will they hear without a preacher and how will they preach unless they are sent? And even when they are sent the implication is they must hear the Word of Christ. So it is again emphasized that the Scripture is the source.
In Ephesians chapter 5, that great section on marriage as compared to the church. Verse 25 says, "Husbands, love your wives just as Christ also loved the church and gave Himself up for her that He might sanctify her having cleansed her by the washing of water with the Word." Christ has cleansed His church, saved His church by the washing of water with the Word. The Word again the agency.
And Paul writing to the Thessalonians in 1 Thessalonians 2:1:13 refers to the work...the Word of God which performs its work in you who believe. The Word works. Now salvation occurs when you have a ready heart that is open to believe, mixed with the revelation of God. The Word of God in a ready heart, that's the issue.
James refers to the same dynamic in James 1:18. He says, "He brought us forth, He begot us, He redeemed us, He saved us by the Word of truth...by the Word of truth."
So, the Scripture, the Word of God, is the source of salvation. That's why Philippians 2:16 calls it the "Word of life." It is characterized as that which gives life. Psalm 19:7, "The law of the Lord is perfect," what's the rest of the verse? "Converting the soul." It has the power to convert.
And I think back to Nehemiah, a tremendous illustration of this. Look with me for a moment to the eighth chapter of Nehemiah, it's a few books to the left of Psalms. And in Nehemiah chapter 8 we have the introduction of a revival. In Nehemiah chapter 8 it begins...the beginning of a real revival. And I believe there were many people who were saved in the true sense of Old Testament salvation at this revival. All the people gathered as one man at the gate which was in front of the water gate, the square which is front of the water gate. They asked Ezra the scribe to bring the book of the law of Moses. Three little words, "Bring the book," really keyed the whole thing. And he brought the law before the assembly of men, women and all who could listen with understanding and the first day of the seventh month he read from it before the square which was in front of the water gate from early morning until midday in the presence of men and women, those who could understand, all the people were attentive to the book of the law.
They stood there and listened to it being read hour after hour after hour. There was a wooden podium, verse 4, set up for that purpose. And Ezra, verse 5, opened the book in the sight of all the people, standing up above the people, and he opened it and all the people stood up. He blessed the Lord the great God and all the people answered, Amen, Amen. Lifting up their hands they bowed low, worshiped the Lord with their faces to the ground. Verse 8 says that as they read from the book, from the law of God, they translated to give the sense so that they would understand the reading...it had to go from Hebrew into Aramaic which was their commoner language and had to be explained to them. And so they were reading and explaining the Word. The people's response was amazing, it says at the end of verse 9, they were weeping when they heard the words of the law. They were grieved over their sin. They were struck because of the dirth of the law of God in their hearing.
The end result of all of this was the people really drew their hearts back to God. This reading went on. At the end of verse 18 it says they celebrated the feast for seven days and they read from the book of the law, the first part of the verse says daily from the first day to the last day. Then the people began to praise God in chapter 9. They were praising and lifting up adoration to the God who had revealed Himself in Scripture. They were getting their hearts right. Down in verse 28 of chapter 10 after that long list of people who signed the document, it says that they were joining together, making a commitment, taking a curse, verse 29, making an oath to walk in God's law, to keep and observe all the commandments of God our Lord and His ordinance and His statutes.
The net result was the people made a commitment to God. And I believe there was salvation that period of time, through that sevenday feast, there was a great movement of God and many were saved. And it was a direct result of simply standing and reading and translating, explaining the Scripture. It has the power to convert the soul, the power to save.
Look at another illustration, taken from the New Testament, namely the eighth chapter of Luke in which our Lord teaches a familiar parable which makes the same major point. Jesus teaching here about the parable of the soils and the sower and the seed. Verse 5 says of Luke 8, "The sower went out to sow his seed and as he sowed, some fell beside the road, was trampled under foot and the birds of the air ate it up. Other seed fell on rocky soil, as soon as it grew up it withered away because it had no moisture. Other seed fell among the thorns and the thorns grew up with it and choked it out. Other seed fell into good soil, grew up, produced a crop a hundred times as great." And He said, "You better listen to the things I'm saying."
Then in verse 9 they asked Him what it was He was saying. He's explaining, starting in verse 10, "To you it has been granted to know the mysteries of the Kingdom of God, to the rest it is in parables in order that they seeing may not see and hearing they may not understand." In other words, He says I'm going to explain it to you because obviously you belong to God. To them it will remain a riddle.
The explanation then comes in verse 11. "In the parable the seed is the Word of God." That which produces new life in good soil is the Word of God. That's the point. If the soil isn't right, you're not going to get the product. If it's hard soil like the soil on the road, it says those beside the road are those who have heard, the devil comes, takes away the Word from their hearts so they may not believe and be saved. And those on the rocky soil are those who when they have received the Word, receive it with joy and they have no firm root. They believe for a while and in time of temptation fall away. And the seed which fell among the thorns, these are the ones who have heard and as they go on their way they are choked with worries and riches and pleasures of this life and bring no fruit to maturity. The Word of God will fall into places where the soil is not ready. Its full of weeds, full of rocks or just hard. But, verse 15, when the seed falls into good soil, those are the ones who have heard the Word in an honest and good heart and hold it fast and bear fruit with perseverance.
So what you have here is the Word of God placed in a readied heart, a prepared heart produces salvation. The practical implications of this are obvious. The heart and soul of our evangelistic ministry must be the Word of God. People will sometimes say, "Well, if you teach the Bible all the time when do you do your evangelism?" Beloved, the Bible is the greatest tool of evangelism. How could we ever come to the point where we would even question such? When Jesus was asked by a lawyer in Luke 10:25 and 26, he said, "What shall I do to inherit eternal life? Jesus said to that man, What is written in the law and how does it read to you?" Go to the Scripture. Go to the Scripture. You can go back to the Old Testament, the sacred writings and they are able to make you wise unto salvation which, of course, has come in the fullness of time through that which Christ has accomplished. What does the Scripture say? Jesus said search the Scriptures for they are they which speak of Me.
And then one very very explicit text. First Peter 1, turn to it for a moment, verse 23, "You have been born again," it says, "not of seed which is perishable but imperishable, that isreferring to the seedthrough the living and abiding Word of God." The seed is the Word of God again. It is that seed placed in good soil that produces salvation. So if we want to be effective in evangelism, we want to teach God's Word. If we want to be effective in reaching our friends, we want to give them God's Word.
Instead of making it very complicated, let me make it as simple as I possible can for you. If you know somebody who is not saved, first thing to do is give them a what? A Bible..Bible, remember that? Don't get too complex. Don't get too carried away with feeling inadequate because you can't explain every theological issue. I mean, you don't need to know all the answers to all the questions, the Bible will be enough.
I talked to a young lady a couple of days ago and she said, "You know, there's so many things I don't understand." Comes out of a drug oriented background. "So many things I don't understand." But she said, "One thing I do understand." She said, "The other night I read the chapter in the Bible called Ephesians," that's the way she said it. "I read the chapter in the Bible called Ephesians. Boy, you can't read that without knowing what the truth is." I said, "Well, that's very interesting." She said, "It's pretty clear there." And I really believe, of course, the Lord has worked on her heart. She has professed faith in Christ and all of a sudden stuff is becoming alive to her but it came through the reading of God's Word.
It's not as complex as we want to make it. And, of course, focusing on that, when you give someone a Bible, encourage them to read Matthew, Mark, Luke and John and see if they can survive that. If they can survive that, the soil isn't ready, there's nothing wrong with the seed. The soil isn't ready. God hasn't prepared the soil. But the seed is there. So we need to be committed to that. He says you have been born again through the living and abiding Word of God. And verse 25 says, "This is the Word which was preached to you." He illustrates it in that passage with a quote out of Isaiah chapter 40, comparing the Word of God to the passing flesh. The Word abides, it lives forever, it does its work, it produces life.
This can be illustrated, I think, quite simply in a rather brief but beautiful account of a woman's conversion in Acts 16. Lydia was her name. And it tells about her in verse 14, just very briefly. "A certain woman," Acts 16:14, "named Lydia from the city of Thyatira, a seller of purple fabrics." This is a business woman, sold purple fabrics for a living. "She was a worshiper of God," that is to say she was upright in the sense of seeking the true God and seeking to worship the true God but had not yet been exposed to the gospel of Christ. She was listening, and then this: "And the Lord opened her heart to respond to the things spoken by Paul. And when she and her household had been baptized," so forth and so on.
I love that. The Lord opened her heart to respond to the things spoken by Paul. That's the essence of salvation. You speak the truth of God's Word and let the Lord open the heart.
Theoretically it wouldn't do a bit of God if the Lord was opening the heart and there wasn't any truth there. It doesn't do any good, also, for us to speak truth if the heart is not open except for the fact that we have discharged our duty. It cannot bring salvation unless the heart is opened. So our task is to spread the Word, spread the seed, preach the truth, give out God's Word and God's part is sovereignly, graciously to open the heart.
The implications again, I just reiterate to you, are clear. Now in evangelism we want to give people God's Word, it's that simple, that basic. I mean, this is...this is primer kind of stuff, very basic. But it helps me as we sort of stop here after nearly 20 years of ministry to just go all the way back and say, "Why are we doing this?" Because this is what we are to do. There isn't anything more. Somebody might say, "Well, you know, we've been doing this a long time, can't we do something different?" No. "I mean, we have been teaching the Bible a long time, we've been having expository teaching, we've been going over this biblical...can't we do something else?" No. There never will be anything else because this is what we're mandated to do, this is that which brings salvation.
There's a second thing, let's look at verse 16 of 2 Timothy 3 and that list that is there indicates four things in addition to salvation that is the work of the word. First is teaching, then reproof, then correction, and training in righteousness. We'll save the last three for next time and look just at the one that the Scripture says is teaching or doctrine.
"All Scripture is inspired by God and is useful for doctrine, teaching." This function obviously takes place after salvation has occurred. You can't give doctrine, you can't teach doctrine to a nonbeliever. Why? First Corinthians 2:14, "The natural man understandeth not the things of God, they are foolishness to him because they are spiritually discerned and he's spiritually dead, but we who are saved," he says in verse 16, "have the mind of Christ." We have the Holy Spirit, 1 John tells us, chapter 2. We have no need to be taught by men because we have an anointing from God who teaches us all things. So when you become a believer you receive what theologians have chosen to call "the ministry of illumination by the Holy Spirit." The Spirit takes up residence in your heart and begins to illuminate the Word to you and you begin to be able to learn what it teaches.
Now the term "teaching" here does not describe a process, it describes content. It describes a body of truth, that which is taught, didaskalia, that which is taught. The Scripture then is to deposit with you truth. It gives you a body of truth by which you are to think and act. That's basically it. The Scripture is a body of truth which is to control your thinking and your acting. And so as you study the Word of God you accumulate that body of truth. And the more of that you accumulate, the more circumscribed to God's standard your behavior, your conduct becomes. But it starts with content.
People, and I've said this for years, people cannot do what they do not know. They cannot function on principles they do not understand. They cannot live out nonexistent truth. If you don't know it, you can't do it. Oh, maybe once in a while you'll stumble across it like the blind pig who finds a slop now and then. But generally speaking, you're only going to be able to do what you understand. And so primarily the Scripture then is there to provide for the saved person a repository of truth, principles for life and thought. In fact, we have noted a couple of times in our study of 1 and 2 Timothy that Paul says to Timothy, "Guard that deposit which is entrusted to you," that body of truth. Paul looked at apostolic doctrine at that which God had taught him and which God had ordained that he pass on as a body of truth to be given. He says in Acts chapter 20, "I have not failed to declare unto you the whole counsel of God. I taught you night and day with tears. I taught you publicly, I taught you from house to house." He preached every weekend in the synagogue. Always, always giving out truth in order that people might have a deposit of truth which would govern their life. And that truth is the same as God's Word. It says in John 17:17 that Jesus said, "Thy Word is truth," to the Father, "Thy Word is truth."
I've always had that kind of a...I don't know, that's almost an insatiable hunger in my own heart, to understand God's Word. It just...I have this hunger to understand it, I want to know what it means by what it says. I can read what it says, I want to know what it means by what it says. And that appetite more than anything else in ministry drives me to study. It compels me. It's the desire to know what God says. I want that body of truth. I don't want any holes. I don't want anything left out. Many people through the years of my ministry have come to me and said, "Well, if I would have known that I never would have done this...well, if I knew that the Bible taught that, I wouldn't have done this...If I would have known that I never would have been in this mess." That's right. You want to know what the Scripture says.
In fact, back in Hosea, do you remember what Hosea's indictment was as God spoke to the prophet in chapter 4? He said, "My people are destroyed for lack of...what?...knowledge." Not lack of zeal, not lack of emotion, not lack of anything but knowledge. They didn't know. And what they didn't know they couldn't live. That's why you need to be in a place that teaches the Word of God and you need to learn the Word of God. Systematic faithful proclamation, declaration of God's truth is foundational to life. We must know God's truth. And so the Scripture gives it to us. It is useful for doctrine. It gives us our framework.
In Exodus 24, I was just thinking where Moses came, recounted to the people all the words of the Lord and all the ordinances and all the people answered with one voice and said, "All the words which the Lord has spoken we will do." That's the attitude. Moses gave them all the words of the Lord...they said all the words of the Lord we'll do. They didn't live up to it but it was a nice thought. It ought to be our commitment too. We want to know all that God said and all that God said we'll do. Why do you think in the great commission we are told to go and make disciples of all men, baptizing them and teaching them to observe all things whatsoever I have...what?...commanded you? We have the tremendous responsibility of giving the deposit of truth.
And that takes a long time. I've been asked a number of times why I stay so long in one church. Well, I haven't covered all the ground yet. There's a lot to cover. And I know sometimes we think we've learned it all, but that's not the case. And yet on the other hand, there's a sense in which we know the principles of God's Word which are illustrated a myriad of ways throughout Scripture, so we are accumulating and understanding that can guard us and guide us through life and seeing it repeated in different circumstances and different settings through Scripture. Men must know God's truth.
Look at Matthew for a moment, chapter 22, just to stretch your thinking one more time in this regard. Matthew 22 verse 16 may be one of the most wonderful commendations of Christ ever given by unbelievers. The Pharisees came and tried to catch Jesus in His words, always trying to get Him so they could eliminate Him. They sent their disciples along with Herodians, strange bedfellows. They said, "Teacher," I love this, "we know that You are truthful and teach the way of God in truth and defer to no one for You are not partial to any." I guess secretly in my own heart that would be what I would desire as a...sometime when I go to the grave somebody might say about me, "You are truthful, you teach the way of God in truth and defer to no one for you're not partial to any." What integrity. What absolute and utter integrity. Jesus taught truthfully the way of God in truth and deferred to no one and was not partial to anyone. He couldn't be intimidated, He was committed to truth. What a commendation. He taught God's truth because that's what men needed to know. It wasn't always popular.
Someone said to me the other day, "Well, you know, I was at a place and a certain person from your church came and spoke. And everything he said was true. But he shouldn't have said it because it offended some people." Well, see, that's a question of, I suppose you want to be cautious, there's no sense in literally blasting away at people in all circumstances. But that's a little bit of the spirit of the age which says, "Don't worry about speaking the truth, be much more concerned with not offending anybody." And so you defer. It's a lot more exciting to just speak the truth and see what happens. You can walk away and say, "Well, it was...how did it go?" Oftentimes you get into a deal like..."Oh, it was nice, every body was real happy, it was good, they enjoyed it." That's...maybe that's not the right response. Maybe you should go away and, "How was it?" "Oh, it was good, it was a riot, it was a riot after I was done, there was a big fight, three people got shot, four people knocked down the building. It was great, it was just wonderful. They were just so upset about the gospel." I mean, maybe that's a different approach. I'm not advocating that at this particular point for every situation, but whatever happened to that kind of approach?
Jesus said...they said of Jesus that He taught always the truth, the way of God in truth, deferred to no one and wasn't partial to anybody. Boy, He didn't defer to anyone thinking He might offend them with what He said and He wasn't partial to anyone...picked no sides.
Paul had that same spirit. Paul says in Acts 20 essentially the same thing. I mean, I'm just going to teach exactly what Christ gives me to teach and I'm going to go and teach it wherever I need to go and teach it and I'm not going to worry about what happens to me, and I'm not going to worry about my own life because I don't count it dear to myself.
See, we want to be committed to the truth, people, to building that body of truth that becomes the garrison that sets the walls up for our behavior, for the way we live life. We must be committed to truth. We must be committed to building that strength. In 2 Chronicles 34 it talks about Josiah, the king stood in his place, made a covenant before the Lord to walk after the Lord, to keep His commandments and His testimonies and His statutes with all his heart and with all his soul to perform the words of the covenant written in this book. Boy, what a devoted man...what a devoted man. Let me tell you what he said again. To keep the commandments, first of all he said to walk before the Lord or after the Lord, to keep the commandments, the testimonies, the statutes with all his heart, with all his soul, to perform the words of the covenant written in this book.
I mean, that's where it starts in Christian living. That's what God is calling, a people who commit themselves to the Word of God. Now what is the practical implication of this? First of all, you have to know it and then you have to...what?...live it. But it starts with knowing it. I have an old Bible at home and I have it open to this first chapter of Joshua, it sits right in the entrance to our home...when you walk in it's the first thing you see and it's open to these verses, Joshua 1:7 and 8, "Only be strong and very courageous, be careful to do according to all the law which Moses, My servant, commanded you. Do not turn from it to the right or to the left so that you may have success wherever you go. This book of the law shall not depart from your mouth but you shall meditate on it day and night so that you may be careful to do according to all that is written in it for then you will make your way prosperous and then you will have success. Be careful to do all that is written in it." Every time you walk in or out of our house, I look at that, I'm reminded that I am responsible before God to do all that is written in that book, to do all that is written in that book. One, I have to know what's written in that book so that I can do it. So I'm committed to the fact that Scripture is the source of doctrine, it's the source of teaching. There's no other source. There is no other place to go, folks, it's all here in God's book. There are other helpful books that comment on this, that expand, elucidate, apply this, but this is it.
Let me give it to you in form of an illustration. Ephesians chapter 6 and we'll just pull it together with this one, Ephesians chapter 6. Verse 17 and here in the armor of the Christian we have a vivid illustration, I think, of the matter of the Word of God and its place in the believer's life. Being armed here with our Christian armor to fight against Satan and his demons described for us in verse 12, he gives all these elements of armor. Basically they are all defensive, a helmet to protect us, a breastplate to protect us, a shield to protect us, our feet shod with the preparation that will protect us, allow us to hold our ground, and so forth. And finally you come to an offensive weapon in verse 17 which is the sword of the Spirit.
Now, just to help you understand this, the sword is the word machaira in the Greek, the word rhomphaia has reference to a large sword, a big sword, three, four feet long even, and that's not the word used here. This is a dagger, somewhere around six inches or so, a small little precise weapon that had to be used in very very precise manner in order to deliver a fatal blow. So the Word of God, first of all, is to be used precisely. It is the sword of the Spirit, not the rhomphaia of the Spirit to be flailed around indiscriminately, you don't bash demons in the head with your huge Bible. The sword has to be used with tremendous discrimination, tremendous astuteness, tremendous care, tremendous skill. So he says the sword of the Spirit and then he tells you what it is. It's the Word of God. And instead of the word logos for Word, he uses the Greek term rhema which basically means a specific statement...a specific statement. It seems to be that he is trying to emphasize here that you use the Scripture with precision, you use the specific statement like a small dagger thrust into a vital area with great dexterity. It isn't the sense that I have the sword of the Spirit because I own a Bible. You could own a lot of Bibles and not have the sword of the Spirit unless you know how to use those specific statements of Scripture which apply at specific points of temptation with precision. That's the issue.
The sword of the Spirit is a precision weapon and it is used with precision to be applied to given situations with precision. And that is why Paul said to Timothy, study or be diligent to show yourself approved unto God, a workman that needs not to be ashamed, rightly dividing the word of truth. You must understand it. You must know how to cut it straight. You must know how to properly interpret and apply it so that you can use the sword.
I see myself as a teacher of God's Word endeavoring to give you the sword at every point. You may...you may know the specific statement of God about a lot of things, but maybe you don't know the specific statement of God about a lot of other things. So if you're attacked in that area, you've got no ability to use that weapon because you don't know that specific statement. The challenge in learning God's Word is to master those truths which give you the deposit so that you have the sword at every point and wherever Satan may attack you you can pull that thing out and use it with precision because you know precisely what the Word of God has to say.
The master illustration of this comes, I believe, in the temptation of Jesus. Do you realize that when Jesus was tempted on those three occasions by the devil that every time the devil tempted Him He answered with...what?...Scripture. He quoted Deuteronomy, a passage out of Deuteronomy. Jesus didn't have to do that. Jesus did not have to quote Scripture, He could have said something and it would have become Scripture. He did not have to quote Scripture. Why did He do that? He was giving us a...what?...a pattern, He was giving us an example. He was giving us a means to understand how to deal with temptation. It was Jesus' spiritual secret, if you will, to borrow a somewhat popular thought. It was letting us in to the heart of Christ and how He dealt with the enemy as the pattern for how we are to deal. And in each case, when the temptation came, Jesus quoted a verse that was a direct rebuttal to that temptation. He had the sword. And He could use that thing with precision to strike a fatal blow. And in essence that's what we are to do.
And that's what happens when the Word of God is imbibed and taken in and when you have the sword you can use the sword and you can use it with precision in any given situation. You become potentially a victor if you apply that which you have. So the Word of God, the Scripture, is useful. It's useful for salvation. It's useful for doctrine. And God wants to bring that Word into our lives as believers constantly, systematically, repeatedly, so that the Word of Christ will dwell in us...what?...richly, abundantly, superabundantly, so that we're literally dominated, saturated, filled with the Word, so that our mind is renewed with the Word in order that we may possess the sword, in order that we may think and act in accord with God's truth.
What is the work of the Word? To save, to teach and it always accomplishes its purpose when it's mixed with a believing receiving heart. And I trust yours is that kind of heart.
You can't stop here because we don't always respond to the Word the way we ought to so the Word also has a ministry of reproof and a ministry of correction and a ministry of instruction which involves chastening. We'll get into that next time. Let's bow together in prayer.
We thank You for that truth in Deuteronomy 8:3 that every Word of God is bread. Father, we thank You for this Word which is indeed bread, which feeds us. Lord, we want to say thank You that the Word came to us and was mixed with faith because You prepared our hearts by Your sovereign grace. We want to thank You that You plowed the soil up, that You allowed Your Holy Spirit, yea, You commissioned Your Holy Spirit to do a convicting work in our heart and we were convicted of sin and righteousness and judgment. The soil was made ready and when the Word came, we believed. We thank You for that life giving Word.
And, Father, we thank You, too, for the deposit of truth, that doctrine which guards our thinking and our acting. We thank You for the fact that You've given us not only the book but You've given us the indwelling teacher, the illuminator, the very author of the book..what a thought...that we should not only possess the book but have living in us the one who wrote it. O Lord, no wonder we don't need to trust men but we have an anointing from the Thee to teach us all things. Help us, Lord, who have been saved by the power of the Word to be built up by its power, to be nourished in the words of faith, good teaching. Help us to allow the Word of Christ to dwell in us richly so that we have the outflow of all those wonderful things described in Colossians 3. Help us to have that mind renewed. Help us to be able to think on things pure and lovely and just and good, things in the Word. May we respond to the injunction of Joshua 1 to never ever let our minds depart from Your Word. May we like the people of old, like Josiah, make a covenant to walk after the Lord, to keep His law and His testimonies and His statutes all the days of our life.
Thank You that You've given us the content to govern life. You've given us the content to defeat Satan. You've given us all we need. We thank You that the Word will accomplish its work in us who receive it, for Jesus sake. Amen.
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SEATTLE – July 23, 2013 – A research team headed by Fred Hutchinson Cancer Research Center scientists Christopher Kemp, Ph.D., and Carla Grandori, M.D., Ph.D., has received a $4 million grant from the National Cancer Institute to develop precision therapies that selectively kill cancer cells while sparing normal, healthy tissue.
Utilizing high-throughput screening and RNA interference to rapidly test thousands of genes in patient-derived tumor cells, the team's work will identify new genes to target that may be highly specific to that patient's tumor.
"Therapies that target specific genes represent the future of oncology treatments," said Kemp, a member of the Human Biology Division at Fred Hutch. "For the most part, cancer therapy hasn't changed over the past several decades. Today's standard treatment is still based on conventional chemotherapy, which attacks all the cells in the body in order to kill the cancer cells. We are pioneering a more precise method that will specifically target cancer cells while sparing the normal cells."
Until recently, the complexities of cancer genomes, the frequent development of drug resistance and the lack of suitable technology have limited the availability and clinical success of targeted therapies. However, using high-throughput screening rather than the traditional method of testing one gene at a time can accelerate the discovery process a thousand-fold, cutting years off the time required to discover new drug targets.
"Most cancer therapies are specific to neither the individual patient nor the relevant underlying molecular features of a particular cancer," said Grandori, a research associate member of the Human Biology Division at Fred Hutch. "Applying high-throughput screening on a larger scale will allow us to identify and precisely target the unique vulnerabilities of cancers and develop personalized treatments," she said.
Although targeted therapies already in the clinic show great promise to be effective without the devastating side effects of chemotherapy, the menu of such therapies is still very limited, Grandori said. "While there a dozen or two targeted therapies, there are more than 20,000 genes, potentially many of them representing future targeted therapies. We have pioneered a method to sort through these thousands of genes efficiently and rapidly in patient-derived cancer cells."
The research team will identify new classes of drug targets and identify patient stratification criteria to match patients to the right drug targets. Initially, the focus will be on the aggressive subtypes of head and neck squamous cell carcinoma, pancreatic ductal adenocarcinoma and triple-negative breast cancer. Plans to expand screening into ovarian and childhood cancer types are also in the works.
The team has already demonstrated success in the preclinical setting; two tumor types for which no effective therapies exist have responded well to novel drug treatments. Kemp and Grandori are hopeful that these studies will be the basis to start clinical trials next year.
"This is just the beginning. We anticipate that our discoveries will lead to the next generation of precision medicines, including novel rational combination therapies tailored to molecular types of cancer," Kemp said. "Working with a local 'dream team' of cancer researchers, oncologists and computational scientists at Fred Hutch, the University of Washington and Sage Bionetworks we hope to bring this breakthrough method out of the lab and into the doctor's office."
Research collaborators include Eduardo Mendez, M.D., an assistant professor of otolaryngology/head and neck surgery at UW and an assistant member of the Clinical Research Division at Fred Hutch; Vijayakrishna Gadi, M.D., an assistant professor of medicine at UW and an assistant member of the Clinical Research Division at Fred Hutch; and Adam Margolin, Ph.D., director of computational biology at Sage Bionetworks.
At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch's pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation's first National Cancer Institute-funded cancer prevention research program, as well as the clinical coordinating center of the Women's Health Initiative and the international headquarters of the HIV Vaccine Trials Network.


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Are YOU Able To See All12 Black Dots In This Picture?
Ready for another optical illusion?
This is the latest brain-buster to take the internet by storm and, we have to admit, we're STUMPED.
According to Gizmodo, this is Ninio's extinction illusion and it's specifically designed to trick you - which is hardly fair.
Take a look at the box below; what you should see are 12 black dots, distributed evenly on a grey, criss-cross pattern.
But what your brain allows you to see is something totally different.
Good luck trying to keep your eye on more than four black dots at any one time!
Struggling? We thought so.
Basically, Ninio has taken advantage of something called "lateral inhibition", which means that "the stimulated light receptors in your eye can sometimes mess with the ones adjacent to them, making you see things that aren't there, or not see things that are there."
Ninio himself explains it as: "When the white disks in a scintillating grid are reduced in size, and outlined in black, they tend to disappear.
"One sees only a few of them at a time, in clusters which move erratically on the page."
Which is why you can probably on keep your eye on a handful at a time - although one man's wife claims to be able to see all 12 at once.
How many black dots can YOU see?
Trending now: Watch a truck and car SMASH together after refusing to merge


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Save BBC 3
BBC 3 should not be axed.
This e-petition has been rejected with the following reason given:
E-petitions cannot be used to request action on issues that are outside the responsibility of the government. This includes:
- party political material
- commercial endorsements including the promotion of any product, service or publication
- issues that are dealt with by devolved bodies, eg The Scottish Parliament
- correspondence on personal issues
E-petitions cannot be used for freedom of information requests.
The following explanatory notes have been added:
this is an operational matter for the BBC.
You can't sign this petition because it wasn't accepted for publication. But you can still give your opinion on it here at Repetition.me!
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Created By
James Daniels
Created On
Saturday 8 March 2014


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MIDDLEBURY — Middlebury police on Christmas Day completed their second annual toy drive, which this year provided gifts to 44 children in 21 families based in Middlebury, Ripton, Vergennes, Weybridge and Brandon.
Local community members and businesses donated gifts for the toy drive, which also featured the participation of the Addison County Sheriff's Department, Vergennes Police Department and Vermont State Police. The gifts went to children who otherwise would have not found much under the tree on Dec. 25.


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"AMERICA'S NEXT TOP MODEL" � (8:00-9:00 p.m. ET)
"For Those About To Walk, We Salute You" (TV-PG, L)
THE MODELS HIT THE RED CARPET � Paulina drops by the loft to surprise the girls with tips on how to behave during press interviews and while attending public events. The girls are dressed by designer Jay Godfrey and must mingle with fashion world VIPs at a cocktail party. One girl breaks down when she realizes she lost her travel document and learns she may not be able to accompany the remaining girls to the secret overseas location (#1008).


text: Anticipate Crop Insurance Changes November 14, 2012 01:56 PM Tweet TAGS: Marketing, Overseas December 18, 2014 By Ed Clark Top Producer Business and Issues Editor Email Anticipate crop insurance changes Several changes to the federal crop insurance program are expected in 2013. For most, it's good news. USDA's Risk Management Agency (RMA) plans to fully implement the rate reductions for corn and soybeans that growers began to see in 2012. "We hope to have that done and in a November filing," says William Murphy, RMA administrator. For most corn and soybean growers, this means a rate reduction. Crop insurance participation for corn and soybeans is at more than 75% because crop insurance is a much better buy than in 1988, when there was only 25% participation. Additionally, wheat, cotton, sorghum, potato and apple growers can all expect their rates to begin falling. Changes Welcome. Previously, a yield history dating back to 1975 was used to determine rates. Once the policy changes are in effect, a 20-year yield history will be used. The new rates are designed to reflect advancements in technology, management and seed. RMA will also offer a pilot program that allows producers to participate based on whole farm and enterprise units. The program will give producers increased coverage at the same price. This change has not yet gone out for comment, according to Murphy, but will soon. Murphy adds that farmers can expect to see two more changes for 2013, a high-risk land exclusion option and revenue protection for pulse crops. The high-risk land exclusion option will allow producers who farm both high-risk and non-high-risk land to either insure the high-risk land under Catastrophic Risk Protection Endorsement coverage or exclude it from coverage altogether. The Pulse Crop Revenue Plan of Insurance will be available to growers of dry beans in select Minnesota and North Dakota counties, as well as dry peas in select areas. Producers can check to see if they qualify by visiting www.rma.usda.gov. Growers must sign up for coverage by the sales closing date, which is generally March 15. One thing is certain, experts say: More farmers will participate in crop insurance programs next year. That always happens after a disaster year, and probably for good reason. Back to news


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Virginia Byway - Frequently Asked Questions
Adventure beckons on the roads and highways designated as Virginia Byways.
More than mere pavement between points A and B, a Virginia Byway offers travelers a side of the commonwealth that is uncommon and enlightening.
Each byway leads to scenes of natural beauty and places of historical and social significance.
Currently, there are nearly 3,000 miles of roads designated as Virginia Byways, yet several hundred more miles of commonwealth roadway could qualify.
To help attract visitors and support economic development through tourism, the Virginia Department of Transportation (VDOT), the Virginia Department of Conservation and Recreation (DCR) and the Commonwealth Transportation Board (CTB), encourage local governments to nominate roads for Virginia Byway designation.
What's the purpose of the Virginia Byway program?
The program identifies road corridors containing aesthetic or cultural value near areas of historical, natural or recreational significance.
By designating certain roads as Virginia Byways, widely distributing "A Map of Scenic Roads in Virginia," and promoting the Virginia Scenic Roads Web site, the program encourages travel to interesting destinations and away from high-traffic corridors.
Byways also stimulate local economies by attracting visitors to lesser-known destinations. One study showed visitors spent $1.8 billion in counties adjacent to the Blue Ridge Parkway in Virginia and North Carolina. This supported nearly 75,000 jobs and generated more than $147 million in tax revenues in the region.
What makes a Virginia Byway different from other roads?
People like to explore. The 2000 Virginia Outdoors Survey, conducted by Virginia's DCR, finds that driving for pleasure is the second most popular outdoor activity, with more than 62 percent of the population participating.
By following the highlighted byways on the state transportation map, the scenic roads map and the scenic roads Web site, visitors are directed to places where they can tour wineries, explore Civil War battle sites and historical attractions, view beautiful scenery and enjoy recreational resources.
Once designated, a byway becomes part of the coordinated promotional strategy for Virginia tourism.
What are other important considerations regarding Virginia Byway status?
- Virginia Byway designation gives localities the opportunity to participate in the National Scenic Byway Program.
- It might limit placement of outdoor advertising signs.
- It does not affect land use controls.
- It does not limit road improvements.
What is a Virginia Byway?
Per Virginia Code, "Virginia Byway" means those highways designated by the Commonwealth Transportation Board (CTB) pursuant to articles §33.2-400 and §33.2-405 through §33.2-408.
The Virginia Outdoors Plan, from DCR, identifies roads that have been considered as having intrinsic qualities of Virginia Byways for many years.
In addition, there are other roads that meet the criteria for designation.
What are the criteria?
To be considered, a segment of road must substantially meet the following criteria:
- The route provides important scenic values and experiences.
- There is a diversity of experiences, as in transition from one landscape scene to another.
- The route links together or provides access to scenic, historic, recreational, cultural, natural and archeological elements.
- The route bypasses major roads or provides opportunities to leave high-speed routes for variety and leisure in motoring. Landscape control or management along the route is feasible.
- The route allows for additional features that will enhance the motorist's experience and improve safety.
- Local government(s) has/have initiated zoning or other land-use controls, so as to reasonably protect the aesthetic and cultural value of the highway.
What are the steps to designation?
1. Anyone can request byway designation, but local government(s) must adopt a resolution of support.
2. Upon receipt of a request and historical documentation from an interested party/local government, VDOT and DCR collect information on local zoning laws, traffic volumes and accident reports before evaluating the roads according to the criteria.
3. Based on a joint review according to the criteria, the DCR director recommends qualifying roads for consideration by the CTB.
4. Before the CTB acts, VDOT offers the local government the opportunity to hold a public hearing. If a public hearing is requested, VDOT's Local Assistance Division and DCR will provide assistance.
5. After the public hearing, or if no hearing was requested, the CTB officially designates the byway(s) at their next scheduled meeting. Subsequently, signs are posted, and changes are made to the appropriate maps.
How can I get more information about the Virginia Byway program?
Contact Carolyn France, 804-786-2586
For additional copies of this brochure or others in the VDOT Answers Your Questions series, please contact:
Virginia Department of Transportation
Office of Public Affairs
1401 E. Broad St.
Richmond, VA 23219
E-mail: firstname.lastname@example.com


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Breaking Dawn Press Conference
Hypable Bill Condon
Question: When did the cast give you enlightenment? And what about having Meyer there?
Bill: the first people who arrived were Rob, Kristen, and Taylor. We just sat in a room talking about every page through the script. They showed a tremendous amount - when an actor embodies a role you'll know it more than they ever will.
Bill: I met with Rob a couple months before we started. We were just having a general talk about Twilight. He mentioned something I ahdn't known before. He'd been a playing a men who was full of regret and who was self loathing. Because of an episode where he broke away from the Cullen family (the early 30s in Chicago) where he'd explore what it'd be like to kill human beings.
Rob thought it was a killed that played on Edward, but it was never played in the movies. There was Midnight Sun where it's really explored. SO we had a conversation about that, I worked with Melissa, and we put it into the beginning of the movie. We understood where Edward was coming from. So things like that, so much comes out of those types of meetings.
Question: Was the chemistry something you felt when you met them?
Bill: We started filming in Brazil. They were staying on the beach, annd then downstairs there people all the time and they couldn't leave their room. It amazed me how gracious they were all the time. I kind of understood it was part of the interest. Generally, one thing that's so exciting is.. you work on every decision and it's going to be studied and reacted to by a large group of people.
Bill: We haven't seen a screening with big crowds of people, except for last night. Rob and Kristen are so relaxed in the acting - it's something they don't even have to act.
More of Bill Condon's Q and A after the CUT. Including mentions from Stephenie Meyer, Peter Facinelli, Nikki Reed, Elizabeth Reeser, and Taylor Lautner
Question: I think it's great how tune you are with all of the fans. This is for them. We heard it was originally rated R?
Bill: It wasn't really rated R. They didn't rate it. They told us we weren't hitting PG 13 yet. It's a very clinical thing. They have very specific guidelines for ratings. Because it's so subjective they have very specific guidelines. I had to be critical but.. thrusting, intercourse. There was never explicit. It's not very different from what you see. Any movement was what was considered not appropriate. Because of the popularity of Twilight it had a bigger focus.
Question: Rob jokingly blamed Kristen.
Bill: Well, Rob's right. (laughter)
Question: Talk about shooting in Brazil.
Bill: We started on the honeymoon in Brazil. I found it great. The crew was great, we had some weather problems.. got rained in and had to sleep in bathtubs in the honeymoon house. But everythign about it was magical. We were five hours outside of Rio, and we had to write a boat into the set every day.
Question: Can you talk about the last day of shooting?
Bill: That was the almost last day. The last day was the middle of April and it snowed. It was hard to shoot in Vancouver. There were two big moments. One was the dance between Kristen and Taylor, and Rob stayed for the whole thing. It ended at dawn.
Bill: Everyone got emotional and Kristen cut it with a joke. Because the last take.. high shot.. I call cut.. she starts running in the wedding dress and starts yelling "Jacob come back come back I've made a mistake!" (laughter) it was great.
And then that whole moment when Alice and Jasper were dancing. But EVERYONE was there. We called cut and everyone hugged each other. It was great.
Via @katespencer
Bill Condon: talking about Rob's decision to play up Edward's self-loathing and how they added that into #BreakingDawn
Bill Condon: Rob and Kristen couldn't leave "their room" in Brazil bc of fan frenzy. Their chemistry is "crazy" #BreakingDawn
Bill Condon addressing the issue of "thrusting" and jokes Kristen got "very into it" #BreakingDawn
Bill Condon on Kristen/Taylor dance shoot: "Rob stayed for the whole thing" #BreakingDawn
Via @taryder
Bill Condon talking about when he first met Rob he brought to light Edward's self-loathing gave Bill idea to show where that came from in BD
Bill talking rob and Kristen chemistry, says they are so gracious
"it's crazy how close they are, it's wonderful" - bill on rob and Kristen. Says its wonderful because "they didn't have to act"
I asked bill about R rated sex scene and if Kristen was really to blame: "I think that's true she was very into it" he laughed
Producer Wyck Godfrey, Stephenie Meyer, Melissa Rosenberg Hypable
Question: What did you think of the birth scene, Stephenie?
Stephenie: I really liked it. It was something.. in the beginning when we developed the story, we weren't sure if it'd be enough. The birth scene, we thought it would be a lot.. some people werent sure if it'd be climatic enough. With the birth scene you could tell it was so emotional. It was.. Edward is losing Bella, and Rob's performance was so heartbreaking that I'm going to admit I teared up. Yes, there were tears because you looked at the idea of losing the thing most important to you.
Bill has such a gift for that
Via @katespencer
Steph: Rob's performance in the birth scene is "heartbreaking." Made her cry! #BreakingDawn
from Elizabeth, Nikki, Peter, Jackson: Rob and Kristen Mentions
Question: How do you feel that Kristen and Rob deal with the media scrutiny? How do you think they deal with it? Do you admire it?
Peter: I've been impressed. People ask if I give them advice, and I don't because you have to go through it your own way. I don't think they've changed who they are, they just have more people surrounding them. They haven't changed and that's nice to see.
Elizabeth: I agree. They had unusual challenges and I don't think I could offer any advice. It's really exciting that they've forgotten to play these roles, and carried us along with them.
Question: What props did you take or borrow from set?
Peter: I tried to take Carlisle's ring. I said it wouldn't come off my finger. And they tracked me down. They wanted to take a mold of it and sell it to the fans, I think. On the fourth one I asked to have one and I think i have one of the originals.
Jackson: I bought one of the Carlisle rings as soon as they came out (laughter)
Nikki: I'm a huge rule follower. So i was afraid of taking something and getting in trouble. They always find out. Kristen stole my sneakers in the baseball scene in the first movie. She came over to my house and said "hey they have two of these, you can have one." They have all the mud on them so I never used 'em.
Taylor's Q and A
Question: Was it upsetting that Edward gets the hot vampire bride and you get a baby? (Laughter)
Taylor: I know! When I was reading the books I was worried. I was like "wait, he's trying to get Bella the whole time and he strikes out so he goes with her child?!" You have to tread lightly. It's not romantic at all. Bill did an incredible job filming it carefully.
Question: What's been your craziest fan encounter? And what's happening next?
Taylor: That's so tough to choose one. I don't like using the word crazy. I like the word passionate. Kristen and I had a very interesting Brazil experience. It was out of control but amazing and there was a lot of passion. I've had a few girls - a tattoo, a picture of you, or a signature on their arm. That blows my mind. Something new happens every single day. You'd think we'd all get used to it and expect it but every time something happens we're like "are you kidding me?" We wouldn't be here promoting a movie if it weren't for the passion.
via RPLife
Posted by RobStenation at 3:49 PM
Labels: BD 1 PressCon


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Unknown gunmen opened fire on a Syrian bus in Deir Emar in northern Lebanon at dawn Monday, killing a Syrian citizen, the Lebanon's National News Agency reported. It added that the gunmen shot at the bus, which was carrying 25 Syrian workers, at 2:30 am in Deir Emar on the Tripoli-Akkar highway, killing 17-year-old Syrian.
A Lebanese security official told Agence France Presse that several other people were hurt. The Lebanese army has secured the site of the attack about five kilometers north of Tripoli.
Ahmed Eid, the mayor of Deir Emar, denounced the shooting attack. "This could be an isolated incident but there are some who will try to take political advantage from it," he said.
Meanwhile, Syria's Foreign Minster, Walid Moallem made a phone call Monday morning to his Lebanese counterpart, Ali Shami, with regard to the "criminal" incident, SANA news agency reported. The Syrian minister demanded to be informed with the results of the investigations carried out by the Lebanese authorities to identify those who are behind the attack.


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AbiWord: System Requirements
This document describes the system requirements we believe necessary in order for someone on run AbiWord reasonably on his/her computer. This is a rough guide, and you may run just fine on a lower-class system than what we describe, or run poorly on a higher-end system. As always, your mileage may vary. With that said, we hope for this to be useful:
Microsoft Windows:
- Windows 2000.
- Windows 95, 98 and ME are no longer supported in 2.6. Use 2.4.6 instead
GNU/Linux, BSD, Solaris (2.6, 7,8,9,10), AIX, HP/UX (10.20, 11.0), OSF/1, Tru64:
- GTK+ 2.12 or newer
- At least 16MB RAM (embedded systems probably won't require more than 8)
- Any processor that supports any of these operating systems (which is effectively, any processor)
Mac OS X:
Note: currently the latest AbiWord version available for Mac OS X is 2.4.5
- Mac OS X 10.2 or later


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Thursday, October 18, 2007
Why Is BCS Sun Not Shining on Devils?
Resume No. 1: A 7-0 record that includes victories over two Mid-American Conference teams, two bottom-feeding Big Ten teams and one I-AA opponent.
Resume No. 2: A 7-0 record that includes victories over Colorado (which beat Oklahoma, No. 5 in the BCS) and Oregon State, plus two other teams from arguably the toughest conference in the land (four of the top 14 teams in the BCS standings are from the Pac-10).
Somehow, the Sun Devils have fallen through the cracks. This despite a resume that is equal or — dare we say it — better than the one put together by the Buckeyes. One brave soul — Neal McCready of the Mobile Press-Register — threw fear aside this week and voted Arizona State No. 1 in the Associated Press poll. Pitchfork Nation caught up with McCready, who spelled out his reasons for putting the Sun Devils at the top of his list.
3 comments:
- TrumanHugh said...
Don't worry about ASSu...Cal will hand 'em their first loss next Staurday, so where the Sun Devils are in relation Ohio State is a needless concern...(BTW, they just lost Ryan Torain, one of (if not THE) their best players, for the season...so sad....)
Could be. But the point is that --this moment-- the gap between them should not be so large in the polls. They're about equal in the computer polls.
- Seamus Furr said...
I'm not often right about this sort of thing, but I told people before this season to watch ASU. Erickson's coaching plus an athlete-friendly school plus the desert atmosphere would create a top-10 powerhouse by '08.
And I was wrong again. By one year.
And if I'm OSU or any other team in the Big 10, I'm more worried about losing my blue chip recruits to ASU than anything.