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In this section
Non-Hodgkin's lymphoma (NHL)
What is non-Hodgkin's lymphoma (NHL)?
Non-Hodgkin's lymphoma is cancer in the lymphatic system. Sixty percent of lymphomas are non-Hodgkin's lymphomas. The lymphatic system is part of the immune system and functions to fight disease and infections.
The lymphatic system includes:
- Lymph fluid - fluid containing lymphocyte cells.
- Lymph vessels - thin tubes that carry lymph fluid throughout the body.
- Lymphocytes - specific white blood cells that fight infections and disease.
- Lymph nodes - bean-shaped organs, found in the underarm, groin, neck, chest and abdomen, that act as filters for the lymph fluid as it circulates through the body.
Non-Hodgkin's lymphoma causes the cells in the lymphatic system to abnormally reproduce, eventually causing tumors to grow. Non-Hodgkin's disease cells can also spread to other organs and tissues in the body.
Non-Hodgkin's lymphoma is the third most common childhood cancer. It occurs most often in children between the ages of 7 and 11, but can occur at any age from infancy to adulthood.
Non-Hodgkin's lymphoma affects males almost three times more often than females, and is more common among Caucasian children than among African-American children and children of other races.
Staging and classification of non-Hodgkin's lymphoma is based on the extent of the disease and the specific cells involved.
What are the different types of non-Hodgkin's lymphoma?
There are three subtypes of non-Hodgkin's lymphoma, including the following:
- Lymphoblastic non-Hodgkin's lymphoma - Lymphoblastic non-Hodgkin's lymphoma accounts for about 35 percent of the cases, involves the T-cells, and usually presents with a mass in the chest, swollen lymph node(s), with or without bone marrow and central nervous system involvement.
- Burkitt's or non-Burkitt's lymphoma - Burkitt's or non-Burkitt's lymphoma is a non-Hodgkin's disease in which the cells are undifferentiated and diffuse. This has also been referred to as small non-cleaved cells. Burkitt's and non-Burkitt's lymphoma accounts for about 40 to 50 percent of the cases and is usually characterized by a large abdominal tumor and may have bone marrow and central nervous system involvement.
- Large cell or diffuse histiocytic non-Hodgkin's lymphoma - Large cell or diffuse histiocytic non-Hodgkin's involves the B-cells and T-cells and accounts for about 15 to 20 percent of the cases. Children with this type of non-Hodgkin's lymphoma usually have lymphatic system involvement, as well as a non-lymph structure (i.e., lung, jaw, brain, skin and bone) involvement.
How is non-Hodgkin's lymphoma staged?
Staging is the process of determining whether cancer has spread and, if so, how far. There are various staging symptoms that are used for non-Hodgkin's lymphoma. Always consult your child's physician for information on staging. One method of staging non-Hodgkin's lymphoma is the following:
- Stage I - involves the tumor at one site, either nodal or elsewhere in the body.
- Stage II - involves the tumor at two or more sites on the same side of the body.
- Stage III - involves tumors in any number that occur on both sides of the body, but does not involve bone marrow or the central nervous system.
- Stage IV - is any stage of tumor that also has bone marrow and/or central nervous system involvement. Stage IV is also subdivided depending on the amount of blasts (cancer cells) present in the bone marrow.
What causes non-Hodgkin's lymphoma?
The specific cause of non-Hodgkin's lymphoma is unclear. It is possible that genetics and exposure to viral infections may increase the risk for developing this malignancy. Non-Hodgkin's lymphoma has also been linked to chemotherapy and radiation therapy. Non-Hodgkin's may be a second malignancy as a result of the treatment for certain cancers.
There has been much investigation into the association of the Epstein-Barr virus (EBV) that causes the mononucleosis infection; as well as the human immunodeficiency virus (HIV), which causes acquired immune deficiency syndrome (AIDS). Both of these infectious viruses have been linked to the development of Burkitt's lymphoma.
The majority of Burkitt's lymphoma cases result from a chromosome rearrangement between chromosome #8 and #14, which causes genes to change positions and function differently, promoting uncontrolled cell growth. Other chromosome rearrangements have been seen in non-Hodgkin's lymphoma (all types) that are also thought to promote excessive cell growth.
Children and adults with other hereditary abnormalities have an increased risk of developing non-Hodgkin's lymphoma, including patients with ataxia telangiectasia, X-linked lymphoproliferative disease or the Wiskott-Aldrich syndrome.
What are the symptoms of non-Hodgkin's lymphoma?
Most children have stage III or IV disease at the time of diagnosis because of the sudden onset of symptoms. The disease can progress quickly from a few days to a few weeks. A child can go from otherwise healthy to having multi-system involvement in a short time period.
Some children with non-Hodgkin's lymphoma have symptoms of an abdominal mass and have complaints of abdominal pain, fever, constipation and decreased appetite - due to the pressure and obstruction a large tumor in this area can cause.
Some children with non-Hodgkin's lymphoma have symptoms of a mass in their chest and have complaints of respiratory problems, pain with deep breaths (dyspnea), cough or wheezing.
Because of the rapid onset of this malignancy, any respiratory symptoms can quickly worsen, causing a life-threatening emergency.
The following are the most common symptoms of non-Hodgkin's lymphoma. However, each child may experience the symptoms differently. Symptoms may include:
- Painless swelling of the lymph nodes in neck, chest, abdomen, underarm or groin.
- Fever.
- Sore throat.
- Fullness in groin area from node involvement.
- Bone and joint pain.
- Night sweats.
- Tiring easily (fatigue).
- Weight loss/decreased appetite.
- Itching of the skin.
- Recurring infections.
The symptoms of non-Hodgkin's lymphoma may resemble other blood disorders or medical problems. Always consult your child's physician for a diagnosis.
How is non-Hodgkin's lymphoma diagnosed?
In addition to a complete medical history and physical examination, diagnostic procedures for non-Hodgkin's lymphoma may include:
- Blood and urine tests.
- X-rays of the chest - use invisible electromagnetic energy beams to produce images of internal tissues, bones and organs onto film.
- Computed tomography scan of the abdomen, chest and pelvis (Also called a CT or CAT scan) - a diagnostic imaging procedure that uses a combination of x-rays and computer technology to produce cross-sectional images (often called slices), both horizontally and vertically, of the body. A CT scan shows detailed images of any part of the body, including the bones, muscles, fat and organs. CT scans are more detailed than general x-rays.
- Lymph node biopsy - a sample of tissue is removed from the lymph node and examined under a microscope.
- Lymphangiogram - an imaging study that can detect cancer cells or abnormalities in the lymphatic system and structures. It involves a dye being injected into the lymph system.
- Bone marrow aspiration/biopsy (to detect cancer cells) - a procedure that involves a small amount of bone marrow fluid and tissue to be taken, usually from part of the hip bones, to further examine the number, size, and maturity of blood cells and/or abnormal cells.
- Lumbar puncture (to evaluate central nervous system disease for cancer cells) - a special needle is placed into the lower back, into the spinal canal. This is the area around the spinal cord. A small amount of cerebral spinal fluid (CSF) can be removed and sent for testing. CSF is the fluid which bathes the brain and spinal cord.
Treatment of non-Hodgkin's lymphoma:
Specific treatment for non-Hodgkin's lymphoma will be determined by your child's physician based on:
- Your child's age, overall health and medical history.
- The extent of the disease.
- Your child's tolerance for specific medications, procedures or therapies.
- The expectations for the course of the disease.
- Your opinion or preference.
Treatment may include (alone or in combination):
- Chemotherapy.
- Radiation therapy.
- Surgery.
- Close monitoring of blood work.
- Bone marrow transplant.
- Bone marrow examinations.
- Lumbar punctures/spinal taps.
- Antibiotics (to prevent or treat infections).
- Long-term follow up care (to determine response to treatment, detect recurrent disease and manage late effects of treatment).
Long-term outlook for a child with non-Hodgkin's lymphoma:
Prognosis greatly depends on:
- The extent of the disease.
- The presence or absence of metastasis.
- The response to therapy.
- Age and overall health of the child.
- Your child's tolerance of specific medications, procedures or therapies.
- New developments in treatment.
As with any cancer, prognosis and long-term survival can vary greatly from child to child. Every child is unique and treatment and prognosis is structured around the child. Prompt medical attention and aggressive therapy are important for the best prognosis. Continuous follow-up care is essential for the child diagnosed with non-Hodgkin's lymphoma. Side effects of radiation and chemotherapy, as well as second malignancies, can occur in survivors of non-Hodgkin's lymphoma. New methods are continually being discovered to improve treatment and to decrease side effects.
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Authority to order support
- collection
The court may, after a hearing on the matter, require the parents or other person legally obligated to support a child alleged to be within the jurisdiction of the court under ORS 419B.100 (Jurisdiction) or a ward to pay toward the child or ward's support such amounts at such intervals as the court may direct, even though the child or ward is over 18 years of age as long as the child or ward is a child attending school, as defined in ORS 107.108 (Support or maintenance for child attending school).(2)
At least 21 days before the hearing, the court shall notify the Administrator of the Division of Child Support of the Department of Justice, or the branch office providing support services to the county where the hearing will be held, of the hearing. Before the hearing the administrator shall inform the court, to the extent known:(a)
Whether there is pending in this state or any other jurisdiction any type of support proceeding involving the child or ward, including a proceeding brought under ORS 25.287 (Proceedings to modify orders to comply with formula), 25.501 (Definitions for ORS 25.501 to 25.556) to 25.556 (Expeditious court hearings), 107.085 (Petition), 107.135 (Vacation or modification of judgment), 107.431 (Modification of portion of judgment regarding parenting time or child support), 108.110 (Petition for support of spouse and children), 109.100 (Petition for support), 109.103 (Proceeding to determine custody or support of child), 109.165 (Vacation or modification of judgment) or 125.025 (Authority of the court in protective proceedings) or ORS chapter 110; and(b)
Whether there exists in this state or any other jurisdiction a support order, as defined in ORS 110.503 (Definitions), involving the child or ward.(3)
The Judicial Department and the Department of Justice may enter into an agreement regarding how the courts give the notice required under subsection (2) of this section to the Department of Justice and how the Department of Justice gives the information described in subsection (2)(a) and (b) to the courts.(4)
The court, in determining the amount to be paid, shall use the scale and formula provided for in ORS 25.275 (Formula for determining child support awards) and 25.280 (Formula amount presumed correct). Unless otherwise ordered, the amounts so required to be paid shall be paid to the Department of Justice or the county clerk, whichever is appropriate, for transmission to the person, institution or agency having legal custody of the child or ward. [1993 c.33 §121; 1997 c.704 §§46,60; 2003 c.116 §16; 2003 c.396 §70a; 2015 c.298 §101; 2021 c.597 §72]
Section 419B.400 — Authority to order support; collection, https://www.oregonlegislature.gov/bills_laws/ors/ors419B.html

subset: commoncrawl


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How do I clean my dwarf and his items in Adventure mode? Currently I've killed a number of things and am covered in blood, leaving a trail of it behind me wherever I walk.
I doubt it'll impress the Queen much if I wander into her hall, leaving a red carpet behind me.


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Though they remain a leading killer, heart attacks can be effectively treated provided they can be rapidly diagnosed following initial onset of symptoms. In a study appearing in this month's Molecular and Cellular Proteomics, researchers have identified cardiac myosin-binding protein C (cMyBP-C) as a potential new diagnostic biomarker for heart attacks, one that may be particularly valuable for mild attacks in which traditional diagnostic proteins may not be abundant enough.
Currently, one of the gold-standards for diagnosis of heart attacks, or acute myocardial infarctions, is scanning for the presence of the proteins troponin I and troponin T, as they are produced specifically in the heart and are almost completely absent in the blood in healthy individuals.
However, even troponins are not ideal markers, since they are released somewhat slowly following a heart attack (peaking around 18 hours post-infarction) and remain in the blood for up to 10 days afterwards, hindering the diagnosis of any secondary heart attacks.
In the quest for better biomarkers, a group of researchers at King's College London performed a proteomic analysis of all the proteins released by mouse hearts following induced heart attacks. They identified 320 proteins not released by normal hearts, including all the currently employed biomarkers.
Only a handful of these proteins were specific to the heart, but among those, one very promising lead was cMyBP-C; within 5 minutes following a heart attack it became nearly 20 fold more abundant than before, one of the highest increases of all 320 identified proteins. In fact, cMyBP-C was abundant following even minor heart attacks, suggesting it could be very useful in such instances.
The researchers are now continuing their investigation and examining the time course of cMyBP-C release following heart attacks and its persistence in the blood of mice, to further determine this protein's potential value.
Story Source:
Materials provided by American Society for Biochemistry and Molecular Biology. Note: Content may be edited for style and length.
Journal Reference:
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Migration Assistant
Under the Help Menu, you can find the Migration Assistant to help you set up Thunderbird the way you want it. If you liked the old toolbar from Thunderbird 2, you can quickly make that change with the Migration Assistant. You can also install add-ons from the Migration Assistant like Advanced Folder Columns and Compact Header for your message display window.
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I just saw that Mr. Camping was "disappointed" after expecting 200 million to be raptured! Wow, what a liberal. When I first heard of this rapture thing, the number was 144,000 exactly, and unbaptized children need not apply! (see below) BTW that's not the number going to heaven, it's the number who are so wonderful they don't have to suffer Tribulation first.
Funny how memes mutate, under criticism. By the time the "Left Behind" series took this up, they realized that sending a billion kids into years of torment might not be the best way to pitch their story! So pre-puberty children got taken up, even from Hindu or Muslim homes! Huge change. Some flexibility! (To get a clear picture of the story they are talking about - derived from a portion of the Christian Bible that Martin Luther personally despised, and that Jesus would have reviled, see Patrick Farley's Apocamon.) So the circle of inclusion has gradually expanded - though it still encourages followers to gleefully relish their inherent superiority and the prospect of their neighbors' coming torment.
(One person writes in to explain the original 144,000 figure: "They were to be the first "fruit" and once they were "sealed" they could go forth and bring the rest of the world in, therefore allowing for many more people. But the first 144,000 were crucial, coming from the 12 tribes of Israel. "Revelation 7:3-8 - saying: "Do not harm the earth or the sea or the trees, until after we have sealed the servants of God on their foreheads." And I heard the number of the sealed, a hundred and forty-four thousand, sealed from every tribe of the sons of Israel" (12 tribes, and 12,000 from each). Jehovah's Witnesses are said to believe in this firmly, and the rest of their member will be left behind to teach."
(Ah... so what part of not harming the Earth is so hard to understand? And why have they stopped mentioning this 144,000 thing? And wasn't the Temple supposed to be rebuilt (God forbid) before all this happens, so the newly Christianized twelve Jewish tribes (including the ten missing ones) can be sealed? In which case, all we need to do, in order to prevent this psychopathic Patmos scenario from ever happening is simply NOT build a building? Okay then.)
The crucial point. This is all so self-centered and solipsistic - so totally focused on the individual's greedy urge to leave everybody else behind - that Jesus would certainly have nothing to do with the whole thing. People who pray for such an event to happen are inherently UNWORTHY of rapture because they are praying for their neighbors to suffer. That's it. Summarized accurately. Top, middle and bottom.
Don't pray for events that will send your neighbor into torment and hell --
-- which is what a number of leading presidential candidates openly avow to do! They avow to follow preachers who openly call more than half of all living Americans "damned souls." Pastors and congregations who pray for the coming of events that will send more than half of their countrymen into agony and eternal hell. Events that will end democracy, abolish rule "by the people" and terminate the United States of America. Events that will rain "fire from the sky."
And these folks want us "damned souls" to vote them keys to our nuclear arsenal.
This isn't just amusing, people. (Though I had hoped there'd be more stunts with empty suits of clothes left on sidewalks!) This matter is one that's relevant to politics and the rise of a new Know-Nothing movement that hates modernity, that hates science. And that hates us.
Every date of prophecies devastation has passed without event. No matter. Doom-seers are well-practiced at the art of recalculation.
I explore this further in my posting: Whose Rapture?
==And a clarification==
Mignon McLaughlin put it, "Youth is not enough. And love is not enough. And success is not enough. And, if we could achieve it, enough would not be enough."
== Some Science and Cool Tidbits.==
This wondrous solar powered plane isn't a gimmick anymore! It looks so retro nostalgic... like something from the 1920s... yet it works. It stayed aloft 26 hours on just sunlight & batteries... and looks so cool. Also, it probably doesn't have much of a heat signature....
Pixar as an early propaganda wing of the Uplift Institute? Pushing the notion of non human intelligence?
The world's leading climate change research organization issued a report yesterday that has renewable energy boosters cheering, as it foresees substantial growth in alternative energy sources over the next 40 years.
The military is taking climate change seriously. A recent report for Mike Mullen, Chairman of the Joint Chief of Staff, said: "We must recognise that security means more than defense" -- urging a strategy of sustainability as climate change is "already shaping a 'new normal' in our strategic environment." The military intends to adapt, as must shipping, insurance, and even oil companies…
No one has ever floated a boat on another world, but NASA is now considering doing just that, on Saturn's icy moon Titan.
Red wine turns metal compound into superconductor. Sake, beer and whiskey also work?
Red colobus monkeys in Uganda's Kibale National Park are being hunted to extinction—by chimpanzees. According to a study published May 9 in the , this is the first documented case of a nonhuman primate significantly overhunting another primate species.
Wow. Stunning video: NASA captures giant comet hitting the sun. My doctorate was for analyzing the composition and behavior of comets BTW. Put a lot of it into Heart of the Comet. And at Caltech I was a solar astronomer! Combo-interests! Amazing.
== As for generations... ==
At last! Someone takes on generational nostalgia! Bill Clinton points out that if the Boomers are worse people than the WWII "greatest generation" then those "greatest" must not have been such great parents, hm? Mind you! I do believe that generation accomplished their historical missions pretty well. Moreover, we boomers have our problems. Our inherent generational trait is self-righteous indignation, a drug high we cannot kick and that is poisoning America with "culture war." America in particular will be better when our calmer kids take over! But that, too is the point.
Looking at our kids, I have to say -- we appear to have been terrific parents.
For H+ Magazine, I was recently interviewed by Ben Goertzel: The Path to Positive Surveillance... on transparency, accountability, surveillance and sousveillance. and our chances to keep a little privacy in the coming age of light.
An example of the "big picture" perspective is this piece I did for Thomas Kuhn's PBS series "Closer to Truth." Are we living in a simulation? -- now posted online: Could Our Universe Be a Fake?
If any of you know teachers or librarians who happen to love science fiction and also live near Northern California or Nevada, clue them in that this year's World Science Fiction Convention - in Reno this August - will feature a college credit course on the teaching of science fiction!


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Draft boards are set up differently around the National Football League. A team that uses a 3-4 defense is going to see talent from a much different perspective than a 4-3 team, for example.
It wasn't too long ago that a team like the Pittsburgh Steelers merely had to figure out which college defensive ends could become 3-4 outside linebackers in order to continue to build their famous 3-4 package.
But over time, things have changed and now the Patriots, Jets, Browns, Chargers, Cowboys and 49ers are all looking for the same players. When you throw in the hybrid defenses that like to jump back and forth from 3-4 to 4-3 packages, there is a much bigger drain on all of the front-seven positions for the 3-4. Don't get me wrong -- great players can play in any scheme, but building a front-seven unit is much different.
So, where is the talent the 3-4 teams are looking for at nose tackle, defensive end, inside linebacker and, of course, the all-important outside linebackers?
There are really two basic 3-4 packages being played in the NFL today. For the lack of a better way of describing them, I will classify one package as the Charger 3-4 and the other as the Patriot 3-4.
San Diego loves to slant its defensive ends almost every play and bring at least one outside linebacker to create a four-man front after the ball is snapped. Because the ends are usually moving on the snap, they put more of a premium on quickness than the other 3-4 teams. The Patriot 3-4 calls for some movement, but will play more of a two-gap style from the defensive ends, so bulk and height are critical.
Teams that use the 4-3 are looking for edge rushers at defensive end and would most likely have a totally different draft board at DE.
At nose tackle, all of the 3-4 teams want a massive man who can command double-team blocks, and speed to stunt is not that critical. The 4-3 teams are looking for a nose tackle about 30 pounds lighter who can move and create blocking problems with stunts.
An inside linebacker in the 3-4 has to be able to take on a 320-pound guard straight up and has to have the bulk and power to neutralize him. A 4-3 inside linebacker is usually going to be lined up off the hip of the nose tackle or under tackle, and that makes it difficult for the guards to get a clean shot at him, which means lighter, quicker linebackers are what the 4-3 teams are in search of on draft weekend.
The outside backers in a 3-4 are pass rushers who can drop in coverage and are high-priced. An outside linebacker in a 4-3 usually has to be a guy who can hold off a tight-end route and be a contain player to turn back a run play to the inside. There are a number of front-seven positions in a 4-3 defense that command a bigger pay check than a 4-3 SAM backer.
In the early '90s, the few 3-4 teams could easily pick up the guys they wanted across the front seven in Rounds 4-6, but with at least seven teams looking for the same players, times have changed.
Look at the Patriots, for example. Their starting three defensive linemen are all first-round selections and they paid big money to acquire OLB Adalius Thomas this year in free agency. Ask any 3-4 defensive coordinator what he wants at every position and he will say Richard Seymour (Patriots) at defensive end, Jamal Williams (Chargers) at nose tackle, James Farrior (Steelers) at inside linebacker, and Shawne Merriman (Chargers) at outside linebacker.
I asked a number of coaches and scouts if they could help me stack a 3-4 draft board, so here are the names we came up with for a 3-4 front.
ALAN BRANCH, MICHIGAN (Round 1) -- He could play in any front, but at 6-foot-5, 324 pounds and 33 bench presses, he could force that double team the coaches desperately want from the nose, and he can run.
TANK TYLER, N.C. STATE (Round 2) -- Not the same size as Branch (6-2, 306) but with 42 reps on the bench, he has the power to do the job.
PAUL SOLARI, UTAH (Round 3) -- A 6-foot-4 344-pound space eater who should force that all-important extra blocker to move him, and that frees up an inside backer.
ADAM CARRIKER, NEBRASKA (Round 1) -- A big player (6-6, 296) who can control the line of scrimmage with his long arms and that all-important height like Seymour.
JUSTIN HARRELL, TENNESSEE (Round 2) -- He has medical issues but did well at the Combine and could be a factor (6-4, 300) at any of the three defensive-line spots.
RYAN McBEAN, OKLAHOMA STATE (Round 3) -- He can move for a big man (6-4, 286) and showed the quickness at the Senior Bowl to play in the Charger style of 3-4.
DAVID HARRIS, MICHIGAN (Round 2) -- Big and thick (6-2, 243) to take on a guard, and at the Combine, he ran the 40 in 4.62, but more important -- a 4.29 short shuttle, which suggests ha can change direction and get off blocks.
ANTHONY WATERS, CLEMSON (Round 4) -- Medical questions but a late workout could resolve the issue. As one scout said, "Go back and look at his junior game against N.C. State. This guy (6-2, 245) is ideal for the strong inside backer spot."
DESMOND BISHOP, CALIFORNIA (Round 5) -- A few years ago, this is the kind of guy (6-2, 239) a 3-4 team would pick up in Round 7 or as an undrafted free agent. One coach said, "Today, he could go a little higher with the 3-4 teams all looking."
ANTHONY SPENCER, PURDUE (Round 1) -- A defensive end (6-3, 261) who can run 4.7 and a 4.4 short shuttle with 27 tackles for a loss last season and 21 career sacks is a prime candidate.
LAMAR WOODLEY, MICHIGAN (Round 2) -- He's short for a defensive end (6-1, 266) but 52½ tackles for a loss and 24 sacks in his career make him a prime OLB candidate.
TIM SHAW, PENN STATE (Round 4) -- Shaw has played defensive end and linebacker (6-1, 236) and if you study the Belichick package, he loves guys who did both in college. Tedy Bruschi, Rosevelt Colvin and Mike Vrabel all had those kind of backgrounds.
ZAK DeOSSIE, BROWN (Round 4) -- I don't care that Zak played in the Ivy League; he is perfect for the 3-4 OLB spot. He runs 4.6 in the 40 and an outstanding 4.2 in the short shuttle. He's strong (6-4, 250) and productive. He has long-snapping skills like his father Steve (former NFL player) and he knows the game.
There are other players who fit the bill for the 3-4 style of defense, but where you take them with so many looking for them is a tougher question. The men running the draft process for New England (Scott Pioli), San Diego (A.J. Smith), Pittsburgh (Kevin Colbert), Cleveland (Phil Savage), the Jets (Terry Bradway), Dallas (Stephen Jones) and San Francisco (Scott McCloughan) would love to find some key players later in the draft, but I think those days are long gone.


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Yay, more beer-related science!
This time, it's around the chemistry involved in that lovely bitterness in beer. As it turns out, this bitterness is provided by a class of chemicals* called alpha acids, which are to be found in the resin of mature hops.
For those living in New Zealand and enjoying the local craft beer industry's obsession with hoppy beers - you know what I'm talkin' about, bitterness-wise :)
Anyhoo, one of the major such acids is called humulone, and it's about this that we'll be talking. During the brewing process, humulone degrades into two isomers**, which are both far more soluble than humulone itself. Up until now, there's been a great deal of confusion about these isomers and their formation.
And so in have stepped the scientists and, in this case, their ability to perform x-ray crystallography. The technique takes the crystals of a compound, and then bounces x-rays off of them - how the x-rays diffract gives valuable information on the compound's physical structure.
And what this group found was that the common notions around humulone (and its derivatives' structure) have been…incorrect.
Why is this important? Well, it's simple. There have, increasingly, been claims that beer (and what makes it bitter), in moderate amounts, can be beneficial for a number of illnesses and complaints***. Some of the claims have linked specific alpha acid isomers (i.e. specific bitternesses) with specific benefits.
The problem is, though, that the configuration of these isomers, and how they're formed, has been a source of confusion for decades. In turn, this prevents the development of any good structure-function relationships for these compounds. If we knew exactly what does what, we can get better at getting the most goodness out of our beer habits. Hell, we may even be able to give people supplements, say, containing only the beneficial compounds. Why anyone would want to lose out on drinking lovely, lovely pints in the process is beyond me, but that probably says more about me than anyone else :P
Or, as the authors put it:
Excessive beer consumption cannot be recommended to propagate good health, but it has been demonstrated that isolated humulones and their derivatives can be prescribed with documented health benefits.21 The absence of correct stereochemical assignment for these compounds has prevented verification of the actual species responsible for biological activity.
So there you have it. With a bit of luck, one day we're going to know exactly which alpha acid isomers are good for what. Can you imagine being prescribed certain types of beer? It's certainly a less bitter pill to swallow for many, as it were :P
And yes, I did indeed toy with doing an 'up-goer fiver' on this :P
Also, amuse that this was published in a German journal…
Urban, J., Dahlberg, C., Carroll, B., & Kaminsky, W. (2013). Absolute Configuration of Beer′s Bitter Compounds Angewandte Chemie, 125 (5), 1593-1595 DOI: 10.1002/ange.201208450
Related posts:
Drink up! Beer benefits bones…
Beer, anxiety and depression – their origins
* Yep. CHEMICALS. You know, the stuff everything's made from. Not 'chemicals' in the sense of 'ew, chemicals, they're bad for you'.
** Isomers are, basically, different forms of the same thing - to be more precise, they're compounds ' isomers are compounds with the same molecular formula but different structural formulas' (thanks, Wikipedia). Sometimes they're mirror images of each other, and sometimes it gets quite a bit more complicated than that.
*** See Beer: Can it help fight off the common cold?, for example. Also, read the paper this post talks about for more examples of other complaints beer has been linked to helping fight.


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Twitter, social media are fertile ground for stock hoaxes
Prominent short-seller David Einhorn raised eyebrows last month when he popped up on Twitter to disavow that he had tweeted about Herbalife Ltd.
Prominent short-seller David Einhorn raised eyebrows last month when he popped up on Twitter to disavow that he had tweeted about Herbalife Ltd.
'Apparently I have a twitter impersonator,' said the hedge fund manager, adding that he had no plans 'to tweet about stocks.'
What set off Einhorn, founder of Greenlight Capital, was a post by a since-suspended Twitter account called @Greenlightcap that read: 'The $HLF tug of war will in the end come down to who has more money to play with. I wouldn't want to be in Bill's shoes right now #TeamIcahn.'
That may have misled people into thinking that Einhorn - whose infrequent tweets under @davidein tend to be about poker - was picking sides in the battle between two other big-name investors, Carl Icahn and Bill Ackman, who have opposing positions in Herbalife.
Einhorn isn't the only shortseller who has been impersonated on Twitter, which has become an important source of information for many investors. In late January, shares of Audience Inc and Sarepta Therapeutics Inc plunged following tweets that were purported to be from short-selling researchers.
'Twitter pump and dump schemes are obviously something for the market to be concerned about, even if they are just a new way for people to do schemes that have been done forever,' said Keith McCullough, chief executive officer at Hedgeye Risk Management in New Haven, Connecticut. He uses Twitter and has more than 22,000 followers.
In such hoaxes, anonymous users set up accounts with names that sound like prominent market players, issue negative commentary, and spark massive declines. The selling that follows shows how the rapid spread of information on social media can make for volatile trading, and is a warning to investors who trade on news before fully verifying the source.
The FBI monitors Facebook and Twitter, and told Reuters in November that social media will be a big part of securities fraud. The U.S. Securities and Exchange Commission's website has a warning that swindlers can use social media 'to appear legitimate, to hide behind anonymity, and to reach many people at low cost.' And the Financial Industry Regulatory Authority has issued social media guidelines to broker-dealers, requiring that they keep records of usage.
In January 2012, the SEC charged an advisor with attempting to sell fictitious securities through LinkedIn Corp, an online social network catering to professionals.
'As some violators have learned the hard way, using social media to defraud investors leaves an electronic trail of footprints for our investigators to follow,' said John Nester, a spokesman for the SEC in Washington, D.C.
Looking for information
Investors can minimize the risk of being conned by only trusting the Twitter accounts of established users and independently researching any tip or rumor.
In addition to Twitter, another popular site for traders is Stocktwits.com, where users send messages almost exclusively about stocks. These sites in some ways are more sophisticated versions of on-line chat rooms that were popular during the dot-com boom. Rumors in those rooms flowed freely, and became a breeding ground for untrustworthy information.
Twitter and StockTwits have stronger filters - the Einhorn impersonator's account was suspended shortly after the misleading post - but the spigot of false information cannot be shut entirely.
StockTwits doesn't allow discussions of penny stocks 'since those are the ones that are the most vulnerable to being pushed around,' said Howard Lindzon, the company's San Diego-based chief executive.
Twitter, which did not respond to requests for comment, verifies the accounts of public figures, focusing on 'highly sought users in music, acting, fashion, government, politics, religion, journalism, media, advertising, business, and other key interest areas,' according to its website.
Analytic firms are also emerging to help traders navigate social media.
The activity in audio chip maker Audience, which has a market value of $275 million, serves as a prime example of the peril of following sources that are not what they seem - and is also where social media scanners see an opportunity.
The initial fake tweet was posted at 8:44 a.m. New York time on January 29, by someone pretending to be short-seller Carson Block of Muddy Waters. Block is best known for exposing accounting problems and taking short positions in a series of Chinese companies listed in the United States.
The share declines did not accelerate until after 2 p.m., when trading picked up, and more than 300,000 shares traded in a two-minute period, far exceeding the stock's daily average volume of about 186,000 shares.
Dataminr, a New York-based social media analytics firm that monitors Twitter for stock activity, said it sent an alert on the fake tweet at 12:28 p.m. The firm 'was able to warn its clients of a market rumor far in advance of the market-movement, along with providing context on the veracity of the message,' said Dataminr Chief Executive Ted Bailey.
While Dataminr declined to provide the actual language of the alert, it said the alert conveyed skepticism about the tweet on Audience, noting the account's past activity and its 'demonstrated domain expertise across the social graph.'
Overall, analytic firms said scanning programs were not advanced enough to be fully automated yet.
'We're a strong believer in the human element in this,' said Emmett Kilduff, CEO of Dublin-based Eagle Intel, a social media analytics firm that has alerts evaluated by a research team composed of former portfolio managers and analysts.
Another analytics firm, London-based Knowsis, filters its alerts through market professionals. CEO Oli Freeling-Wilkinson said the firm looks at who is sending information, taking into account the person's location, whether they are an established market professional, and how shares react.
No system is fail proof, and big share reactions will still likely occur from time to time, goosed initially by Twitter but later as investors react to price moves. It is this aspect that will keep people on their toes.
'There's an impulse, when you see a name of yours moving like this, to shoot first and ask questions later and find out why it is moving,' said Sam Ginzburg, head of trading at First New York in New York.
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Correct Installation of a Downdraft Ventilation
Checking the Installation for your Jenn-Air Downdraft Vent
If you are unsure about connecting your Downdraft Vent, follow the following tips:
What is the length of the vent system?
- The length of vent system and number of elbows should be kept to a minimum to provide efficient performance.
- The maximum equivalent length of the vent system is 60 ft (18.3 m). Refer to the Installation Instructions of your appliance for specific information.
- For altitudes above 4,500 ft (1372 m), reduce recommended vent run by 20% for best performance.
Was the correct vent material used?
- Use 26-gauge minimum galvanized or 25-gauge minimum aluminum metal vent.
- Poor quality pipe fittings can reduce airflow.
- Flexible metal vent is not recommended.
- Metal duct may be reduced to 30-gauge galvanized steel or 26-gauge aluminized steel if allowed by local codes. This reduction is based on information in the International Residential Codes Section M1601.1 (2006 edition).
NOTE: Local codes may require a heavier gauge material.
How many elbows were used?
- Use no more than three 90° elbows.
- Do not install 2 elbows together. Make sure there is a minimum of 18" (45.7 cm) of straight vent between the elbows if more than one elbow is used.
- Elbows too close together can cause excess turbulence that reduces airflow.
- If an elbow is used, install it as far away as possible from the hood's vent motor exhaust opening.
- Do not use a 5" (12.7 cm) elbow in a 6" (15.2 cm) or 3¼" x 10" (8.3 x 25.4 cm) system.
Follow the instructions below for best performance:
- Do not reduce to a 5" (12.7 cm) system after using 6" (15.2 cm) or 3¼" x 10" (8.3 x 25.4 cm) fittings.
- Avoid forming handmade crimps. Handmade crimps may restrict airflow.
- Use a vent cap for proper performance. If an alternate wall or roof cap is used, be certain the cap size is not reduced and that it has a back draft damper.
- Use vent clamps to seal all joints in the vent system.
- Use caulking to seal exterior wall or roof opening around the cap.
If you would like to download or view product literature for your appliance, please visit our Manuals and Literature page.


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Do mothers accurately identify their child's overweight/obesity status during early childhood? evidence from a nationally representative cohort study
(Springer Nature, 2018-06-19)
Background: Maternal recognition of overweight/obesity during early childhood is a key determinant in achieving healthy weight status in children. The aim of this study is to 1) investigate maternal perceptions of their ...


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Dreaming of a White Way Christmas! From St. Louis to Rent, Watch Five Holiday Musical Moments
The holiday season is in full force and our Christmas playlists are accompanying us everywhere we go. Because wrapping gifts goes faster while you listen to showtunes (proven fact!), we compiled some of our favorite holiday scenes from musicals. After all, some of the greatest Christmas carols were originally written for stage and movie musicals. From Judy Garland to the cast of Rent, click below for a warm holiday treat.
"We Need a Little Christmas" from Mame
Who doesn't need a little Christmas in their lives? After Mame Dennis loses her fortune in the stock market crash of 1929, the high-society dame rallies her nephew. After Tony Award winner Angela Lansbury originated the song in 1966 production, Jerry Herman's tune went on to become a holiday classic, performed by everyone from Kathie Lee Gifford to the Muppets to the cast of Glee.
"Have Yourself a Merry Little Christmas" from Meet Me In St. Louis
Judy Garland immortalized many songs, but "Have Yourself a Merry Little Christmas" from the 1944 movie Meet Me In St. Louis ranks among the most-performed holiday songs of all time. Written by Hugh Martin, Garland sings this number to console her young sister (Margaret O'Brien), who is upset by the family's impending relocation to New York. The tune was included in the Broadway staging of the musical in 1989 and has been recorded by countless artists, including Frank Sinatra, James Taylor and Kelly Clarkson.
"Turkey Lurkey Time" from Promises, Promises
Christmastime is the season of giving, family and wild company parties. Promises, Promises contains one of the greatest onstage office celebrations with "Turkey Lurkey Time." This scene from the 2010 revival features a bevy of secretaries bursting with the holiday spirit as they sing Burt Bacharach and Hal David's ode to everyone's favorite Christmas feast.
"New Deal for Christmas" from Annie
There's nothing more heartwarming at Christmas than a happy ending, and that's just what we get when Annie is adopted by Daddy Warbucks. The finale of Annie, set during a lavish Christmas party at the Warbucks mansion, features Charles Strouse and Martin Charnin's warm and fuzzy "New Deal for Christmas." Here are Broadway revival stars Lilla Crawford and Anthony Warlow performing the cheery number.
"Christmas Bells" from Rent
In Jonathan Larson's Rent number "Christmas Bells," cops, drug dealers and the city's homeless sing out about the holiday. See the final cast of the Broadway production, featuring Will Chase, Adam Kantor, Renee Elise Goldsberry, Tracie Thoms and more create this memorable moment.


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WASHINGTON – It's come to this for Republicans straining to defend their Senate majority in November's elections: They're air-dropping millions of dollars into races in Alabama, Kentucky and other red states where Donald Trump coasted during his 2016 presidential election triumph.
This year, challenged by Trump's fumbled handling of the coronavirus pandemic, the crippled economy and his racially inflammatory stances, Republicans face potentially competitive races they'd normally have locked down. Compounding their problems is strong fundraising by Democratic candidates that's kept them in contention in unlikely locations.
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"The president's weakening poll numbers over the last several months have made down-ballot races more competitive," said GOP pollster Whit Ayres. While saying he believes Republicans will win many of the contested seats, Ayres added, "It's fair to say the map is expanded."
GOP fretting is being aggravated by some polls showing Trump trailing nationally and in some battleground states against Joe Biden, the presumptive Democratic presidential nominee.
And while it's early and well-known senators can differentiate themselves from an unpopular president atop their ticket, Democrats are defending just 12 Senate seats this November to Republicans' 23. The GOP controls the Senate 53-47.
"Donald Trump's failed handling of the coronavirus crisis has changed everything," said Democratic pollster Geoffrey Garin. He said GOP senators are linked too closely to Trump, leaving him "pleased and surprised by the willingness of so many Republicans to go down with the ship."
Democrats have at least a puncher's chance of grabbing Republican-held seats in four states Trump won by double digits: Alaska, Kansas, Kentucky and South Carolina. They have an even shot at ousting GOP Sen. Steve Daines in Montana, which Trump carried by 20 percentage points, and long-shot hopes of retaining their most endangered senator, Doug Jones of Alabama, where Trump won by 28 points.
Republican incumbents face legitimate challenges for two Senate seats in Georgia and difficult fights in Arizona and North Carolina, all where Trump won narrowly. In two states Trump won by 9 points, Iowa GOP Sen. Joni Ernst faces a tough Democratic opponent in businesswoman Theresa Greenfield, while Republican Sen. John Cornyn is on alert against a Texas upset.
Republicans say they'll keep their majority, aided by Trump attacks on Biden that will close the overall gap by Election Day. They argue that Trump's name on the ballot will give Senate candidates in Republican states a major edge and say they're spending there because Democrats are raising sums that can't be ignored.
"The left's antipathy toward the president becomes an easy rallying cry" for Democratic fundraising, said Steven Law, who leads a pair of outside groups aligned with Senate Majority Leader Mitch McConnell, R-Ky.
Former North Dakota Sen. Heidi Heitkamp, a moderate Democrat who lost her 2018 reelection bid, said she believes Trump's struggles have put red areas in play, especially transitioning Southern states like North Carolina, Georgia and Texas.
"Don't run away from who you are," like hedging on whether you'll vote for Biden, said Heitkamp, a founder of One Country, which advises Democrats on connecting with rural voters. "Run on health care, things that affect your community."
In early TV spots, the National Republican Senatorial Committee accuses Democratic Senate candidate Jon Ossoff in Georgia of backing "policies so extreme only Hollywood would want him." One by the Democratic Senatorial Campaign Committee accuses Ernst, the GOP senator from Iowa, of protecting corporate interests, adding, "In tough times it's important to know who has your back."
Although dollars don't always translate into votes, campaign reports filed this week show surging Democratic fundraising in solidly Republican terrain.
Jones' $18 million haul in Alabama more than quadruples the amount raised by his Republican opponent, Tommy Tuberville, a former Auburn football coach. That's prompted One Nation, a group allied with McConnell, to line up $3.2 million on ads helping Tuberville, with the conservative Club for Growth planning $1.3 million more.
In Montana, Daines is on even financial footing with his Democratic opponent, Gov. Steve Bullock. One Nation and the Senate Leadership Fund, another McConnell ally, are spending millions to help Daines, while the DSCC, Senate Democrats' campaign arm, and Majority Forward, allied with Democratic leadership, are helping Bullock.
The two McConnell-friendly groups are even aiming $15 million at Kentucky to help him fend off an uphill challenge from Democrat Amy McGrath. The $47 million she has raised so far, aided by Democratic contributors' antipathy to McConnell's work with Trump, is tops in the country and surpasses McConnell's $38 million.
Even in Kansas, which hasn't elected a Democratic senator since before World War II, a group with ties to state and national Republicans plans to spend $3 million to prevent the polarizing Kris Kobach from winning the party's Senate nomination. Top Republicans fear a Kobach nomination could mean victory for Democrat Barbara Bollier, who's collected more cash than the three GOP contenders combined.
The two McConnell-allied groups are preparing to spend $22 million to help GOP Sen. David Perdue against Democrat Ossoff in Georgia, where Republican advantages among suburban voters have eroded. An expensive battle is brewing over Ernst's Iowa seat, with outside Democratic and GOP groups each planning to spend over $20 million.
Other robust Democratic fundraisers include Mark Kelly in Arizona and Jaime Harrison in South Carolina. Kelly has a solid chance of defeating GOP Sen. Martha McSally while Harrison is waging an unlikely drive to oust Republican Sen. Lindsey Graham, a close Trump ally.
Cornyn has a dominant money advantage over MJ Hegar, his Democratic challenger in Texas. While some early polling has shown Biden running well there, Republicans are confident of a Cornyn win, barring a Trump collapse.
Republicans are eyeing Alaska, where GOP Sen. Dan Sullivan's likely opponent is Al Gross, an independent with Democratic support. The sprawling state is difficult to poll and populated by notoriously free-spirited voters, and Gross, a doctor, has already spent $700,000 of his own money on his campaign.
Scott Kendall, a Republican consultant, predicted Sullivan will win. But, he cautioned, 2020 is "the weirdest year any of us have seen."
Associated Press writers Bruce Schreiner in Louisville, Ky., and Becky Bohrer in Juneau, Alaska, contributed to this report.


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Kubota Tractor Corporation unveiled its new North American Headquarters building in Grapevine today with a ribbon cutting ceremony with Governor Greg Abbott, Masatoshi Kimata, President and Representative Director of the Kubota Group, along with State and local officials. The company's move to Texas from Torrance, California, is the most significant change it has undertaken in its successful 45-year history in the U.S.
The Building:Kubota's new Corporate Office facility was built with sustainability features designed specifically to qualify for the LEED Gold certification. The building features a "net zero" system for water use, which means the building's design collects all rainwater and uses it for irrigation as well as supplemental fortification of the river between the Research and Development building and office buildings.
All existing trees that were native to the site were retained during construction. Additionally, all of the materials used in the project were selected based upon recycling content, with over 75% made from recycled material. The construction of the project contained less than 10% of materials going to a sanitary waste facility - 90 percent of all other materials were recycled. Photo Credit: Mike Reyher


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1. Chipped Nails
According to L.A.-based manicurist Jenna Hipp, if it's minor, dab a touch of rubbing alcohol directly on the area to remove oils, then follow with a spot of matching color over the chip. Two minutes later, apply a top coat. If you're prone to post-mani chips, Hipp recommends trying a nude shade that mimics skin (like HIPPxRGB Nail Foundation Nail Lacquer, $16) so it's less visible. "Steer clear of metallic and matte finishes that tend to accentuate imperfections and are harder to cover up."
2. Broken Heel
Unless you have some serious secret cobbling skills, fixing a broken heel requires professional attention. "Depending on the severity, an emergency tube of ShoeGoo can be a temporary solution," says Chassie Post, lifestyle editor at Gilt.com in NYC. "Otherwise, the stilettos have to come off." She always tucks a pair of roll-up flats in her purse, just in case.
3. Fallen Hem
Keep a roll of hairpiece tape handy. "It's called TopStick [$4, try wigwarehouse.com and it's a stylist's best friend, responsible for keeping J.Lo in her dresses, RuPaul in his wigs, and repairing hems in a jiffy," Post explains. "If I don't have it on me, I use masking tape, duct tape, even a stapler [paint the staples black with a Sharpie] to fix a rogue hem." A paper clip works in a pinch, says Shopbop stylist Aya Kanai. "If it shows, just roll with it as part of the look."
4. Loose Button
If you don't have time to break out the sewing kit, a twist tie can also do wonders on small buttons — "remove paper, thread wire through the button, and twist the tie in back," says Post.
5. Migrating Makeup
When lipstick or eye products begin to run, Uzo, the bicoastal and international lead makeup stylist for Nars, suggests forgoing traditional removers and using a primer instead. "Removers have a tendency to wipe away the entire look rather than just fixing one area," she says. "Place a drop of oil-free primer on the edge of a Q-tip and gently swipe away migrating makeup." Or, Uzo adds, try a concealer. Blending in a small amount will correct a minor mess.
6. Deodorant Mark
No matter how fervently the label emphasizes its non-streaking ability, most deodorants leave a residue, particularly on dark clothing. In those instances, Gilt.com's Post reaches for baby wipes. "They always do the trick," she says. "Look for travel-size containers [available in most drugstores] so they fit in your purse."
7. Stuck Zipper
Don't panic and tug too hard on the fabric — that never ends well. Shopbop's Kanai suggests instead using a bar of soap: Rubbing it gently along the stuck zipper should do the trick.
8. Flat Hair
The quickest body booster is dry shampoo (try Naturia by René Furterer, $24). "Turn your head upside down and spray the scalp area with the product, brush through from root to end, then fluff," suggests Sean Davis of Manhattan salon Tosler Davis. "Flip hair back, style if necessary, and add a bit of hairspray."
9. Perfume Overload
If you've spritzed once too many — generally that means no more than one pump on each side of the neck and one on each wrist — Kilian Hennessy, founder of fragrance line By Kilian, says it's best to grab a washcloth and quickly wipe away excess scent from anywhere perfume was applied. If the scent remains intense, try an unscented soapy towel.
10. Clumpy Mascara
Avoid the issue by waiting for the first coat of mascara to dry before applying a second. Or, use a lash comb. "Start from the base of the lashes and wiggle through to the tips until they separate," suggests Uzo. If mascara has already completely dried, comb through with a wand that has been dipped in a capful of makeup remover. "Make sure it's oil-free; otherwise, additional emollients can interfere with the product's durability."
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22 Jan, 2021
Be a Sponsor or Exhibitor! This event is an excellent platform to promote your organization to influential players and investors in the industry.
Contact firstname.lastname@example.com or (65) 69506973
Not sure if you can join us live?
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We can provide flexible and tailored packages to optimise your investment, contact Cynthia on +(65) 69506973 or firstname.lastname@example.com to discuss about customizable Sponsorship packages.


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Call the phone number printed on the sign to obtain more information about the pending application.
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For more information, please email email@example.com or call 240-545-8976.
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Section 27-6303 of the Prince George's County Zoning Ordinance requires that each development application (including building permits and use and occupancy permits) subject to review for compliance with the off-street parking and loading standards include a parking plan or site plan indicating compliance with the standards in Section 27-6300. These spaces are required to serve the parking and loading needs of all persons associated with the building(s) and use(s). Requirements for specific uses can be found in the Table of Minimum Number of Off-Street Parking Spaces in Table 27-6305(a) of the Ordinance.
A request for a formal Zoning or Subdivision Ordinance Interpretation must be submitted in writing as an application to the Development Review Division. The interpretation request should be of either the Ordinance text, zone boundary, compliance with conditions of approval, whether or not an unlisted use is comparable to a listed use (i.e. should it be allowed or prohibited in a zone), or other provisions of the Ordinance. The interpretation application must identify the nature of the request, provide all necessary background information, include section(s) of the Ordinance for interpretation, and Indicate specific use(s), subdivision standard(s), map(s), and/or condition(s) of approval in question, as applicable.


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Create a Website Account - Manage notification subscriptions, save form progress and more.
The Veterans Service Office is a County Department governed by the Klamath County Board of Commissioners. Federal and State regulations determine the guidelines for veterans' benefits. Our staff interprets regulations, helps gather required documentation, and assists in filing claims for disability, pension, and for survivor and dependents benefits
Mission Statement
It is the mission of the Veteran's Service Office to provide assistance to veterans, dependents, and survivors in filing for Federal and State benefits.
... to care for him who shall have borne the battle and for his widow and his orphan.- Abraham Lincoln
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Jon Barocas is the founder and CEO of bieMEDIA, a Denver-based online marketing and media solutions company that specializes in video content production and distribution, mobile visual search, technology platforms, SEO, VSEO and more.
Like most technology fans, I am always ready and willing to try any technology that promises to simplify my life. QR codes seemed to present an accessible and uniform way for people with smart devices to interact with advertising, marketing and media. Those little squares of code seemed to open a world of opportunity and potential. But after using them for a length of time, I shifted my perspective.
My initial honeymoon with QR codes was very short-lived. The initial rush that I had received from trying to frame the code on my device had lost its luster. I started to view QR codes as a barrier to additional information. And in many instances, the rewards (whatever I received as a result of scanning the code) did not measure up to the effort of the transaction itself.
Consider a recent study by comScore, which states that only 14 million American mobile device users have have interacted with a QR code. In essence, less than 5% of the American public has scanned a QR code. So where's the disconnect?
Inadequate technology, lack of education and a perceived dearth of value from QR codes are just three of the reasons mobile barcodes are not clicking with Americans. But it goes deeper than that.
Humans are visual animals. We have visceral reactions to images that a QR code can never evoke; what we see is directly linked to our moods, our purchasing habits and our behaviors. It makes sense, then, that a more visual alternative to QR codes would not only be preferable to consumers, but would most likely stimulate more positive responses to their presence.
The QR Alternative
Enter mobile visual search (MVS). With MVS, you simply point at a product or logo and shoot a picture with your smartphone's built-in camera. Within seconds, the MVS application will provide product or company information, or even the option to make a purchase right then and there on your mobile device.
MVS is a far more compelling and interactive tool to enable mobile marketing and commerce. In today's increasingly mobile world, instant gratification is the norm, and taking the extra step of finding a QR code scanner on your mobile device no longer makes sense. With MVS, you are interacting with images that are familiar and desirable, not a square of code that elicits no reaction.
The opportunities are boundless with MVS. Unlike two-dimensional barcodes and QR codes, MVS will have wrap-around and three-dimensional recognition capabilities. Even traditional advertising will be revitalized with MVS. For example, picture an interactive print campaign that incorporates MVS as part of a competition or game. Marketers can offer instant gratification in the form of videos, mobile links, coupons or discounts as incentive for taking the best pictures of a particular product or logo.
The world has already started to migrate to MVS. For example, companies in Argentina and South Korea currently allow commuters waiting for subways or buses to view images of groceries or office supplies. Embedded within these images are recognitions triggers: Smartphone users place and pay for an order to be delivered or picked up within minutes.
Also, MVS can cash in on word-of-mouth marketing. Marketers will seamlessly link their campaigns to social networks so consumers can share photos and rewards, such as vouchers, coupons or music downloads, with their friends and followers.
QR Code Security Risks
In addition to being a more versatile medium, mobile visual search is also more secure than QR code technology. Cybercriminals are able to cloak smartphone QR code attacks due to the nature of the technology — QR codes' entire purpose is to store data within the code. There is no way to know where that code is going to take you: a legitimate website, infected site, malicious app or a phishing site. MVS's encryption modality will eliminate the opportunity for malicious code to download to your smartphone.
Recently, there have been documented cases of QR code misuse and abuse around the globe. For instance, infected QR codes can download an app that embeds a hidden SMS texting charge in your monthly cellphone bill. QR codes can also be used to gain full access to a smartphone — Internet access, camera, GPS, read/write local storage and contact data. All of the data from a smartphone can be downloaded and stolen, putting the user at risk for identity theft — without the user noticing.
Mobile visual search is a safer and more secure technology that can provide more information and content than a QR code, without as many security risks. By focusing on real-world objects and images rather than code, MVS lessens the risk of a virus or Trojan attack.
Safety, security and versatility — there are many reasons that MVS will supplant QR codes. However, there is one important, largely overlooked reason to favor MVS over QR codes: For the first time, we will be able connect with our actual surroundings in a truly interactive way. We will be able to provide a virtual marketplace that is familiar and accessible. Humanizing this interaction and making it more visual are the foundations of MVS's imminent success.
Image courtesy of iStockphoto, youngvet
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Saturday, October 23, 2010
Borough Market London
33 comments:
Oh yes, you just made me very hungry! That first shot especially of the bread and cheese and croissant...
After that, though, I love how British the market is: the pork pies and sausages and ethnic foods. Hearty, smelly fare. Miam!
(I do hope you treated yourself to some l'Artisan chocolates??)Apple Day?!! I bet that's fabulous. I was just thinking this morning that it's getting chilly, and that means apple crisp weather, all toasty and warm topping, made with oats and brown sugar, with homemade ice cream on top. Looks like great fun, Carol--I love markets like this--looks like our farmers' market, which I miss when I'm on the road.
ReplyDelete- Andres in Budapest10:49 AM
Hi Carole,
i'm in budapest trying deliciously hearty goulashs and pork axles!
The dog is a Berenese hound, original from Bern, switzerland. Related to the also swiss Saint Bernard!
Love your posts, and i'll use them greatly as i'm in paris next weekend. (if i can skip the strikes...)
Sent from the road. OH, Carol...this food fest has sent me over the edge. I love watching Samantha Brown's travels on the Travel Channel and recently they aired the episode where she went to this market and had a toasted cheese sandwich (heaven). I must go now. Also I love that the sign about the sausages said "lashings" of gravy. Somehow makes gravy sound tasty to me and I normally keep away from the stuff. here's to Happy travels with more to share...


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TASCHEREAU, THOMAS-JACQUES, agent of the treasurers-general of the Marine, councillor in the Conseil Supérieur, seigneur; b. 26 Aug. 1680 at Tours, France, son of Christophe Taschereau, Sieur de Sapaillé, king's councillor, director of the mint and treasurer of the city of Tours, and Renée Boutin; d. 25 Sept. 1749 at Quebec.
Pierre-Georges Roy* claimed that the nobility of the Taschereau family was of long standing. Whether or not that is true, it was of the nobility of the robe, and it had lost a great deal of its prestige by the time its first and only representative to come to Canada, Thomas-Jacques Taschereau, arrived in the country. He was descended from a line of royal or municipal officials whose toponymical surname was Sapaillé; but to Canada he brought the surname Linière, which belonged to another branch of the family in France.
Thomas-Jacques Taschereau, baptized privately at his birth, received public baptismal rites only at the age of 14, and thus was able to sign his baptismal certificate. Almost immediately afterwards he lost his father and mother. Nothing more is known about him until Claude-Thomas Dupuy*, who had been appointed intendant of New France, brought him with him as his private secretary. If he accompanied his master on the same ship to Canada, Taschereau would have left Paris in June 1726, to arrive at Quebec on 18 August.
During his brief stay of two years, Intendant Dupuy was immensely active, and his secretary must not have languished in idleness. But as a result of the trouble which developed after the death of Bishop Saint-Vallier [La Croix*], Dupuy was recalled and returned to France in the autumn of 1728. Taschereau, perhaps counting too much upon the security of his employ, had taken a wife on 17 January of that year; it was time for him to think of marrying, since he was already 48. He married a Canadian girl who belonged to the nobility and who was not yet 20, Marie-Claire, daughter of Joseph de Fleury de La Gorgendière and grand-daughter of the discoverer Louis Jolliet*. With this responsibility, Taschereau remained some time at Quebec; there, in February 1729, he had his first child, who was buried a few days later, baptized. Then he returned to France, and was there with his wife in February 1732 when he was appointed to succeed Nicolas Lanoullier de Boisclerc as agent of the treasurers-general of the Marine in Canada. Canon Pierre Hazeur* de L'Orme, in Paris at the time, wrote to his brother Joseph-Thierry Hazeur: "M. Taschereau has his office as treasurer. He is going back this year with his wife. . . . I think he will do well in that country. We have always been good friends since his return from Canada. As for M. Dupuy and his wife, I have not been to see them at all. If they had both followed Taschereau's advice, they would not be in the situation they are today."
In addition to the office of agent, which bore with it prestige and a relatively lucrative salary, Taschereau received the office of councillor in the Conseil Supérieur, one of the highest responsibilities in the colony, on 1 April 1735. Used to administering public funds, the agent had the idea of speculating on his own account by entering into partnership on 16 Oct. 1736 with François-Étienne Cugnet, Pierre-François Olivier* de Vézin, Jacques Simonet d'Abergemont, and Ignace Gamelin* the younger to exploit the Saint-Maurice ironworks. The lack of experience of the manager of the company, Olivier de Vézin, brought the undertaking to bankruptcy in 1740 and the king, who had advanced the main part of the finances, took it over.
The best known and most lasting achievement of Thomas-Jacques, ancestor of the huge and illustrious Taschereau family of Canada, remains however his contribution to the settling of the seigneury of Sainte-Marie and the development of the Nouvelle-Beauce region. On 23 Sept. 1736 three adjoining seigneuries, all the same size, were granted by Governor Charles de Beauharnois and Intendant Gilles Hocquart* to Joseph de Fleury de La Gorgendière and his two sons-in-law, Taschereau and Pierre de Rigaud* de Vaudreuil. The seigneuries of Sainte-Marie, Saint-Joseph, and Saint-François were surveyed by Noël Bonhomme, dit Beaupré in December 1737. Taschereau received the first grant, which was behind the seigneuries of Lauzon and Jolliet, beginning at the Île au Sapin and consisting of "land with a frontage of 3 leagues and a depth of 2, on both sides of the river called the Sault de la Chaudière."
The settlement of the Beauce region began in 1738 and the three seigneurs carried out in the allotted time the condition set by the authorities that "they build a carriage and cart road which will follow the river" as far as the Île au Sapin. On 2 Aug. 1738 the first native of the Beauce, Joseph-Marie Raymond, son of Étienne Raymond and Marie-Cécile Mignot, was born in the seigneury of Sainte-Marie. In less than two years Taschereau granted 28 pieces of land, thus creating the embryo of a parish; the grants belonging to Fleury de La Gorgendière and Rigaud de Vaudreuil constituted a separate nucleus centred upon the chapel of the seigneury of Saint-Joseph. In the autumn of 1739 the region of Nouvelle-Beauce already had 262 inhabitants.
In the course of one of the earliest surveys on his seigneury Taschereau had had the church site marked out and a piece of land reserved for the parish priest; later, on 25 Feb. 1746, he donated it formally by deed to the bishop of Quebec, who was at the time Pontbriand [Dubreil]. He did still more for the religious life of his censitaires. In 1741 he had ordered from Paris all the articles of worship for the chapel which was at that time installed in the seigneur's home at the place called "le Domaine," and he had given from his own furnishings a fine painting of the Madonna, chosen as the patron saint of the parish in honour of the lady of the seigneury.
As he was kept in Quebec by his duties as agent and councillor, Taschereau the seigneur must have come only rarely to his seigneury; at no time is his presence mentioned in documents. On 1 July 1745 he entrusted the material organization of his seigneury to an attorney-at-law, Étienne Parent, whom Intendant Hocquart had commissioned the previous year to act as surveyor in Nouvelle-Beauce. From then on the life of the parish and seigneury finally knew its full development.
At his death on 25 Sept. 1749 Thomas-Jacques Taschereau owned one of the two houses that were later to form the site of the bishop's palace in Quebec; his great-grandson, Elzéar-Alexandre Taschereau*, was to become famous in the palace as the first Canadian cardinal. After her husband's death Mme Taschereau was left well enough off, and, despite the long service of her husband, "a very honest man moreover," she was not able to obtain a royal pension. She saw to the education of the eight children who remained of the 14 whom she had borne. Marie-Anne-Louise entered the Ursuline order in Quebec and became superior of the convent; the youngest child, Gabriel-Elzéar*, was the only one to continue the name and became the second seigneur of Sainte-Marie. Taschereau's widow died at Quebec on 19 Feb. 1797, after having lived for several years with her son in the manor-house of Sainte-Marie.
AN, Col., B, 56, f.140v; 58, f.465v; 62, f.20v; 63, f.462v; 64, f.421; 65, ff.413, 423v, 436v; 66, ff.13, 24, 249; 76, ff.44, 86v; 81, f.66; 87, f.26v; 89, f.23; 91, f.30v; C11A, 66, f.249; 92, f.58; 93, ff.29, 193. ANDQ, Registres des baptêmes, mariages et sépultures, 25 sept. 1749. ANQ, Greffe de Jacques Imbert; Greffe de J.-N. Pinguet de Vaucour; AP, Famille Taschereau. ASQ, Fichier des écoliers. PAC, MG 18, H17. "Contrat de concession d'un terrain pour l'église de Saint-Marie, Nouvelle-Beauce," BRH, XIII (1907), 372–73. "Lettre du comte de La Galissonière à madame Thomas-Jacques Taschereau," BRH, VIII (1902), 328. "Recensement de la Nouvelle-France, 1739" (Census of Canada). Gaumond, Les forges de Saint-Maurice. Honorius Provost, Sainte-Marie de la Nouvelle-Beauce: histoire civile (Québec, 1970); Sainte-Marie de la Nouvelle-Beauce: histoire religieuse (Québec, 1967). P.-G. Roy, La famille Taschereau (Lévis, Qué., 1901). Henri Têtu, "Le chapitre de la cathédrale de Québec et ses délégués en France," BRH, XVI (1910), 206, 226.
© 1974–2024 University of Toronto/Université Laval
Cite This Article
Honorius Provost, "TASCHEREAU, THOMAS-JACQUES," in Dictionary of Canadian Biography, vol. 3, University of Toronto/Université Laval, 2003–, accessed March 4, 2024, http://www.biographi.ca/en/bio/taschereau_thomas_jacques_3E.html.
The citation above shows the format for footnotes and endnotes according to the Chicago manual of style (16th edition). Information to be used in other citation formats:
Permalink: | http://www.biographi.ca/en/bio/taschereau_thomas_jacques_3E.html |
Author of Article: | Honorius Provost |
Title of Article: | TASCHEREAU, THOMAS-JACQUES |
Publication Name: | Dictionary of Canadian Biography, vol. 3 |
Publisher: | University of Toronto/Université Laval |
Year of publication: | 1974 |
Year of revision: | 1974 |
Access Date: | March 4, 2024 |


text:
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text:
An official website of the United States government
News Release 2010-103 | September 2, 2010
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WASHINGTON — The Office of the Comptroller of the Currency released today its 16th annual Survey of Credit Underwriting Practices and reported that the trend of tightening underwriting standards has continued for the last three years. However, the OCC is beginning to see some easing of standards in response to competition, and a slight improvement in credit market liquidity.
"Credit performance remains a concern despite several years of tightening," said Deputy Comptroller for Credit and Market Risk Dave Wilson. "We are beginning to see some recent signs that standards may be loosening. That's good for credit markets as long as bankers remember to stick to sound underwriting principals and do not compromise standards because of competitive pressures or the assumption that loans will be sold to third parties."
Despite tightened underwriting standards, examiners noted that risk in both the commercial and retail portfolios increased for the third consecutive year and they expect portfolio risk to increase over the coming year. This increase was largely due to the combined effects of loans that were previously underwritten with more liberal standards coupled with continued economic weakness. This year's survey also indicated that the majority of banks are using the same underwriting standards regardless of whether they intend to hold or distribute credits.
The OCC's survey is a compilation of examiner observations and assessments of credit underwriting standards at the largest national banks. The 2010 survey included 51 of the largest national banks and covered the 12-month period ending March 31, 2010. The aggregate total of loans was $4 trillion, which represented over 93 percent of all outstanding loans in the national banking system.
Kevin M. Mukri (202) 874-5770


text:
It's that time of year again! Although it's almost too late to start a batch of sauerkraut in order for it to be ready in time for gift-giving (or perhaps to mail a tea set to you niece in Amsterdam), it's perfect timing to start thinking about most other gifts.
Last year we made bath salts for the people we love. The recipe is here along with a big list of other thoughtful ideas for people who may (or may not) be going through cancer treatment. We have a fresh new list of ideas this year too.


text:
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Mitt Romney may want to reconsider his campaign strategy involving the pint-size voters of tomorrow.
The Republican presidential candidate skipped the chance to take part in Nickelodeon's "Kids Pick the President" special that includes President Barack Obama, said Linda Ellerbee, the show's host and executive producer. The decision "disses" children, she said.
During last week's presidential debate, Romney vowed to cut federal funding for PBS while acknowledging it's the home of popular "Sesame Street" character Big Bird.
"Kids Pick the President: The Candidates," with videotaped questions for the candidates from youngsters nationwide, debuts Oct. 15 on the children's channel. Afterward, an online poll asks kids to make their pick.
Romney's campaign said "he simply didn't have time. He couldn't fit it in his schedule," Ellerbee said Monday.
His decision is disappointing because "answering kids' questions directly shows respect for the several million kids who will vote in Nickelodeon's 'Kids Pick the President' campaign," she said.
"That's several million kids who actually want to get involved in the democratic process," Ellerbee said. "They don't deserve to be dissed. But former Gov. Romney also blew off Letterman and Big Bird, so I guess we're in good company."
The Romney campaign did not immediately respond to email and phone requests for comment.
Since 1992, when Nickelodeon began airing the Q&As, only two other candidates have declined to take part, Ellerbee said: Democratic contender John Kerry said no in 2004, which prompted President George W. Bush to withdraw. Bush participated in 2000.
The online kids' polling has gotten the outcome right five out of six times, including Bush's re-election in 2004, Ellerbee said. Democratic contender Al Gore was the children's pick in 2000.
"It's not always that Democrats win" the poll, she said. "It's not that we're some left-wing show and that's the only kids that watch us."
Nickelodeon has been in touch with Romney's representatives since April and they had been "encouraging" about prospects for the former Massachusetts governor's involvement, Ellerbee said.
The candidate has until Monday to reverse his decision, she said.
An Obama campaign spokesman jumped on Romney's decision when asked for comment, saying, "It's no surprise Romney decided to play hooky" and jabbing at the GOP candidate over education and PBS funding.
"Unfortunately for Mitt Romney, 'The dog ate my homework' just doesn't cut it when you're running for president," spokesman Adam Fetcher said in a statement.
For the special, Obama fielded questions regarding gun control, jobs, illegal immigration, same-sex marriage and bullying. He also was asked about his most embarrassing moment, Nickelodeon said.
"Running into the wall is par for the course for me," the president replied. "I'm running into doors and desks all the time."