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The benefits of continuous positive airway pressure machines (CPAP) for patients with obstructive sleep apnea (OSA) are quickly reversed when the therapy is withdrawn, according to Swiss research.
The findings appear online in the articles-in-press section of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
"In patients with obstructive sleep apnea who are established on CPAP treatment, withdrawal of the therapy is associated with a rapid recurrence of OSA and sleepiness within a few days" said Malcolm Kohler, MD, senior consultant at the Sleep Disorders Centre and Pulmonary Division of the University Hospital in Zurich. "After 14 days of CPAP withdrawal, OSA patients experienced considerable increases in heart rate and blood pressure as well as a deterioration in vascular function."
The researchers recruited patients who had been previously diagnosed with OSA and treated with CPAP and were registered in a database of the Sleep Disorders Centre in Zurich. Patients were randomized to either continue CPAP therapy or to withdraw CPAP (maintaining a sub-therapeutic level) for two weeks. After baseline polysomnography, patients underwent nightly at-home assessment of respiration and oxygen saturation each day of the study period. Patients were also assessed for subjective and objective sleepiness, psychomotor performance, blood pressure and heart rate, endothelial function (a marker of vascular function), systemic inflammation, insulin resistance and urinary catecholamines (a marker of sympathetic nervous system activity.) The polysomnography was repeated at the end of the two-week period.
Not surprisingly, at the end of the study period there was a significant increase in apneic events, oxygen desaturations and the number of arousals during sleep. As a consequence of the recurrence of sleep-disordered breathing, subjective sleepiness increased in the CPAP withdrawal group "Withdrawal of CPAP was associated with a rapid return of sleep-disordered breathing within a few days," said Dr. Kohler.
Importantly, endothelial function deteriorated considerably in the CPAP withdrawal group, and there was a marked increase in blood pressure and heart rate after two weeks. Additionally, the researchers found a significant increase in urinary catecholamines, hormones consistent with sympathetic nervous system activation. These findings imply that withdrawal of CPAP therapy for even a short time has a measurable negative effect on the cardiovascular system.
"We have shown that CPAP withdrawal leads to a return of OSA within the first night off CPAP," said Dr. Kohler. "In addition to strongly suggesting that OSA patients should bring along their CPAP machines on holiday, these findings have implications for OSA research going forward. CPAP withdrawal represents a new way to investigate the physiological effects of OSA and evaluate novel treatments," he explained.
"Many clinical trials involving OSA patients suffer for low recruitment rates of eligible participants. This study points to a simple solution that would circumvent the problem of poor recruitment and could dramatically improve both the quantity and quality of OSA research. Rather than recruiting eligible patients from the sleep laboratory or clinic the proposed approach uses databases including data from a large number of OSA patients. Thus the required number of eligible patients with specific characteristics can be recruited selectively within a short-time," he went on. "This would allow us to improve the efficacy of randomized controlled trials in this area."
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Book of Me Written By Me is more pathetic than ever. The bloom is off
the rose. My fault entirely, of course: lack of commitment, a
preference to pick and choose, too many eclectic pursuits, creative
excuses like I have to clean my kitchen or my hard drive crashed, and so on.
Maybe I can hustle into combining the missing ...
Maybe I can hustle into combining the missing ...
and Journals (Prompt 6) are something I gave up on —
apart from travel journals and boring attempts to track
medical-health issues —
because Facebook appeared and it has a lot of leniency for recording
the important, exhausting trivia of daily life. My Latvian
Grandparents (Prompt 7) have been written into posts on
this blog; my Scots-descended Grandparents whom I never
knew personally are admittedly a bit neglected. No-one has yet
pressed me to hear about Will's gentle decline into depression after
his brother got run over by a train, a brother who may or may not
have ruined the family business.
Time Capsule (Prompt 8)is simply not big enough to hold
(I should say choose) a few treasures or cryptic artifacts. A memo
attached to my will that lists the family heirlooms (few) and
personal treasures (many) including provenance for all is quite
enough to gobsmack my kids. Halloween (Prompt 9) and
sticky little children I avoid at all costs but do pay due respect to
All Saints Day and All Souls Day.
Now, faithful reader, you will find a hiatus here until the festive season is truly cranked up to Code Green levels. I'm just taking my fest a bit early and away.
recall offhand any Unexplained Memories (Prompt 10) but
would this count? An old recurring dream about being shot in the
spine has since been replaced by being lost in a huge hotel —
make of that what you will, Dr. Freud.
That moves us right along to Military (Prompt 11). And
like many Geneabloggers, I did a post for the eleventh day of the
eleventh month. In fact it's sitting right below this one. In my
families, there's a certain dearth of eligible ancestors and
collaterals in the military category. Why? —
there we go, another adjunct idea to mess around with.
future, applying myself better would be worthy of all those others who are
creating such interesting posts.
The Desert Life, June 2013 |
Now, faithful reader, you will find a hiatus here until the festive season is truly cranked up to Code Green levels. I'm just taking my fest a bit early and away.
2013 Brenda Dougall Merriman

subset: commoncrawl


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I sure didn't dress properly for the weather yesterday!
When I left my house to meet my friends it was 40 degrees and it was just sprinkling… I was even planning on wearing shorts but changed my mind last second to wearing some thin pants instead.
With each mile of our run it started raining harder and harder and then at about mile 4 it was a complete blizzard. AKA we were soaking from the rain and then it got really cold from the snow/wind. It was cold during the run but when I sat down in the car afterwards I started shivering like crazy and had to sit there with the heater on for a while before driving because I was so cold.
I am SO glad I wore a hat. I would have called an Uber to pick me up if I hadn't worn one and had those huge snowflakes hitting me in the eyes while running.
The water fountain that has the most refreshing water (I swear it is straight from the very top of the mountain) that never ever turns off… this fountain has saved me on hundreds of runs!
I was planning to get in my tempo miles yesterday but that plan definitely did not happen:
I ran with two of my friends and was reminded quickly how much I love running with them. Josse is running pain-free again so I'm sure we will get together more now and my other friend just did a 2:47 marathon so hopefully I can join her on her easy easy easy days;)
10 miles @ 8:42 average and those tempo miles will happen today on the treadmill instead.
I got home and took the hottest shower ever and then got back in bed with a hot chocolate for a few minutes.
We had a few appointments in the morning but canceled those because it kept snowing and snowing and there was no way I was going to drive in those conditions.
When my sister and I were younger we would draw our dream houses and they included an underground tunnel from one house to the other.
Maybe our childhood dreams will come true:
Because we were stuck inside for a lot of the day we got some things done including putting away the laundry… Skye was a great helper.
We played a lot.
We made some hamburgers (the picture was not pretty) for lunch along with some sides… And then once it stopped snowing and the roads were plowed we went to the gymnastics gym with my sister and her family.
Brooke has nailed her vault sprint.
We did our normal crockpot chicken for chicken salads and sweet potato fries from TJs.
I wanted to include this question from a reader in it's own post so we could talk a bit more about it in the comments! *How do you help your kids, especially Brooke, develop a healthy relationship with food?


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The Parks, Peaks, and Prairies Route begins in West Yellowstone, Montana, and heads eastward through several national parks and monuments: Yellowstone, Devils Tower, Mt. Rushmore, and the Badlands. It ends in Minneapolis, Minnesota, where spurs will connect to the North Lakes and Northern Tier routes.
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Alarmed by the growing financial stress at the nation's two largest mortgage finance companies, senior Bush administration officials are considering a plan to have the government take over one or both of the companies and place them in a conservatorship if their problems worsen, people briefed about the plan said on Thursday.
The companies, Fannie Mae and Freddie Mac , have been hit hard by the mortgage foreclosure crisis. Their shares are plummeting and their borrowing costs are rising as investors worry that the companies will suffer losses far larger than the $11 billion they have already lost in recent months. Now, as housing prices decline further and foreclosures grow, the markets are worried that Fannie and Freddie themselves may default on their debt.
Under a conservatorship, the shares of Fannie and Freddie would be worth little or nothing, and any losses on mortgages they own or guarantee — which could be staggering — would be paid by taxpayers.
The government officials said that the administration had also considered calling for legislation that would offer an explicit government guarantee on the $5 trillion of debt owned or guaranteed by the companies. But that is a far less attractive option, they said, because it would effectively double the size of the public debt.
The officials also said that such a step would be ineffective because the markets already widely accept that the government stands behind the companies.
The officials involved in the discussions stressed that no action by the administration was imminent, and that Fannie and Freddie are not considered to be in a crisis situation. But in recent days, enough concern has built among senior government officials over the health of the giant mortgage finance companies for them to hold a series of meetings and conference calls to discuss contingency plans.
A conservatorship or other rescue operation would be the second time in four months that the Bush administration has stepped in to engineer a rescue to prevent the financial system from collapsing. Last March, it forced the sale of Bear Stearns to JPMorgan Chase to avert a bankruptcy of that venerable investment house.
Officials have also been concerned that the difficulties of the two companies, if not fixed, could damage economies worldwide. The securities of Fannie and Freddie are held by numerous overseas financial institutions, central banks and investors.
Under a 1992 law, Fannie or Freddie could be put into conservatorship if their top regulator found that either one is "critically undercapitalized." A conservator would have sweeping powers to overhaul them, but would not have the authority to close them.
The markets showed fresh signs on Thursday of being nervous about the future of the companies. Their stock prices continued a weeklong slide, hitting their lowest level in 17 years. The debt markets, meanwhile, pushed up the two companies' cost of borrowing — their lifeblood for buying mortgages.
The companies are by far the biggest providers of financing for domestic home loans. If they are unable to borrow, they will not be able to buy mortgages from commercial lenders. In turn, that would make it more expensive and difficult, if not impossible, for home buyers to obtain credit, freezing the United States housing market. Even healthy banks are reluctant to tie up scarce capital by offering mortgages to low-risk home buyers without Fannie and Freddie taking the loans off their books.
Together the two companies touch more than half of the nation's $12 trillion in mortgages by either owning them or backing them. They hold more than $1.5 trillion of the mortgages as securities. Others are sold to investors in the form of mortgage-backed bonds.
In recent weeks, the companies have spiraled downward, undermined by declining confidence in their future and shaken by sharp declines in their assets as the housing markets have continued to slide and foreclosures have risen.
In the last week alone, Freddie has lost 45 percent of its value, and Fannie is off 30 percent. Expectations of default at the companies have also risen; it costs three times as much today to buy insurance on a two-year Fannie bond as it did three years ago.
Analysts expect the companies to announce a new round of write-downs and possibly be forced to raise capital by issuing additional shares, which would dilute their value for current shareholders.
Despite repeated assurances from regulators about the financial soundness of the two institutions, financial markets have concluded that by some measures they are deeply troubled.
Freddie, for instance, is technically insolvent under fair value accounting rules, in which the company puts a market value on assets as if it had to sell them now.
Although Treasury Secretary Henry M. Paulson Jr. and Ben S. Bernanke, the chairman of the Federal Reserve, passed up invitations by lawmakers on Thursday to seek legislation to deal with the crisis, officials said that the administration had been privately considering a government takeover should the markets continue to turn against the companies.
At a hearing of the House Financial Services Committee on Thursday, both Mr. Paulson and Mr. Bernanke were guarded, carefully trying not to say anything that could further erode confidence in Fannie and Freddie. They both said that the regulator of Fannie and Freddie had found that they were, in the words of Mr. Paulson, "adequately capitalized," meaning that they had sufficient cash and other assets to withstand the turbulence in the markets.
"Fannie Mae and Freddie Mac are also working through this challenging period," Mr. Paulson said.
Neither official would address a question posed by Representative Dennis Moore, Democrat of Kansas, who asked whether the failure of either institution would pose a risk to the financial system.
"In today's world I don't think it is helpful to speculate about any financial institution and systemic risk," Mr. Paulson said. "I'm dealing with the here and now, and the important role that they're playing and other financial institutions are playing."
Mr. Bernanke said that Fannie and Freddie "are well-capitalized in the regulatory sense" but added that they, and other major financial institutions, needed to raise their capital levels further.
Despite repeated denials by officials in the Bush and prior administrations, financial markets have long assumed the government would stand behind Fannie Mae and Freddie Mac in times of difficulty, both because they are integral to the housing and financial markets and because the companies have a line of credit to the Treasury.
But Congress set that credit more than 38 years ago, long before the companies rose to such size and prominence, and its limit, $2.25 billion for each, has become a tiny fraction of the companies' overall debt.
Some analysts have begun to propose that the Fed also permit the two companies to borrow from it, as Wall Street investment banks began doing after the rescue of Bear Stearns. But there is no indication that the Fed is contemplating such a move.
On Thursday, the rapid sell-off of shares of Fannie Mae and Freddie Mac came after a former central banker made comments that the companies might not be solvent, and an analyst at UBS issued a report critical of Freddie Mac.
The turmoil also shook the debt of the companies, with one main measure indicating that their cost of borrowing has risen to the highest level since mid-March, when the government rescued Bear Stearns. Throughout the day, senior officials sought to reassure the markets about the financial health of Fannie and Freddie.
Later in the afternoon, James B. Lockhart, the regulator who oversees the two companies, issued a statement that his agency was carefully watching the companies' "credit and capital positions" and said that they were adequate to get through the current turmoil.
Fannie Mae issued a statement saying that it remained financially strong.
"Our company has raised more than $14 billion in capital since November 2007, including $7.4 billion most recently in May," the company said. "As our regulator has stated, and has reiterated in public statements this week, we are adequately capitalized."
Sharon McHale, vice president for public relations at Freddie Mac, said: "Our regulator has emphasized that we have continued to maintain the highest capital rating, and we are in the market every day. We'll continue to do so."
Shares of Freddie Mac plunged more than 30 percent and Fannie Mae's more than 20 percent in the first hour of trading on Thursday. By the close of trading, Fannie shares had fallen nearly 14 percent, and Freddie shares had dropped 22 percent. It was the second straight day of declines for the companies.
While their stocks trade on the New York Stock Exchange, Congress created the two companies to promote housing, and the marketplace has long come to believe that they would be bailed out should they become insolvent. They hold a far lower level of capital than banks do. In recent years, they have both suffered from accounting scandals and management shake-ups.
Neither Mr. Paulson nor Mr. Bernanke, at the hearing on Thursday, would answer a question about whether Congress needs to give the regulators more tools to deal with the possible insolvency at either company.
"I don't think we should be speculating or talking about what-if's with any particular institutions, and so with Fannie or Freddie, what I'm emphasizing is that the tool that I want is the reform and the reform legislation that would inject confidence into the marketplace," Mr. Paulson said, referring to a measure that would revamp the oversight of the companies.
The problems of the two companies spilled onto the campaign trail on Thursday when Senator John McCain, the presumptive Republican nominee for president, said he supported federal intervention to save Fannie or Freddie from collapsing.
"Those institutions, Fannie and Freddie, have been responsible for millions of Americans to be able to own their own homes, and they will not fail, we will not allow them to fail," Mr. McCain said during a stop at the Senate Coney Island Restaurant in Livonia, Mich. "They are vital to Americans' ability to own their own homes. And we will do what's necessary to make sure that they continue that function."
Jason Furman, the economic policy director for the Democratic presidential campaign of Senator Barack Obama of Illinois, said that Mr. Obama "believes the Bush administration's willful neglect of warning signs in housing, in financial markets and in the job market, have compromised the nation's housing finance system."
"The challenges facing Fannie and Freddie are part of the broader weakness in our economy," Mr. Furman said.
Senator Charles E. Schumer, Democrat of New York and chairman of the Joint Economic Committee, said that the markets should rest assured that the mortgage giants have a "federal lifeline" and would not be allowed to fail — though he said he thought a government rescue would not be needed and should be a last resort.
Charles Duhigg and Jenny Anderson contributed reporting from New York; Michael Cooper from Livonia, Mich.; and David M. Herszenhorn from Washington.


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On the last Food Makers episode of the year, I'll be chatting with author, farmer and grassfed beef rancher Shannon Hayes about her new book Long Way on a Little, a decidedly pro-meat cookbook and overall guide to healthy, thrifty, and self-sufficient living. Tune in on Google+ at 2pm PST and 5pm EST right here.
Shannon runs lives on a 160-acre farm in upstate New York with her family where she farms and writes books about clean living. I loved her previous book Radical Homemakers, a thoughtful critique and study of how to become less of a consumer and more of a home-based producer. Long Way on a Little is written in the same, well-informed vein. In true DIY spirit, she's also created her own publishing company, Left to Write Press.
Join Make: Community Today


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There is no vaccine for malaria, which sickens almost a quarter of a billion people each year and kills a child every 30 seconds. That could be changing: researchers at The Rockefeller University have genetically transformed the yellow fever vaccine to prime the immune system to fend off the mosquito borne parasites that cause the disease. The researchers found that the modified vaccine, along with a booster, provided mice with immunity to the deadly disease. The findings were reported online May 6 in the journal Vaccine.
Malaria is one of the most pressing health crises of developing countries: in communities stricken by infection, attendance at work and school drops, and poverty deepens. It has been known since the 1960s that one form of the malaria parasite — called the sporozoite — can wake up the immune system and help to protect against future infection. The only way to gather sporozoites, however, is to pluck them one-by-one from the salivary glands of irradiated, malaria-ridden mosquitoes. To provide immunity, the attenuated parasites must then be injected in high doses — or delivered by the bites of hundreds of mosquitoes — a labor intensive approach not feasible for large-scale use.
"We needed to come up with another way to get the benefits of sporozoite immunization," says Charles M. Rice, head of the Laboratory of Virology and Infectious Disease. Along with researchers from Michel C. Nussenzweig's Laboratory of Molecular Immunology at Rockefeller and colleagues at New York University, Rice and his team considered that fighting infection with infection might be the key. They began experimenting with the attenuated yellow fever strain used in the yellow fever vaccine, known as YF17D, which has been used to successfully vaccinate more than 400 million people since 1937. Previous work in the Rice laboratory and by others had shown that this vaccine strain could be modified to include short sequences from other pathogens, including malaria.
In experiments published last month in Vaccine, the researchers inserted the nearly complete sequence of a malaria gene into the YF17D vaccine and found that the gene could produce its protein in cultured cells. The protein they chose, called CSP, covers the surface of the malaria sporozoite and is thought to be the main reason that this form of the parasite stimulates the immune system so effectively.
Immunization of mice with the YF17D-CSP vaccine led to a measurable jump in immune activity against the malaria protein, but the single shot was not enough to protect the animals from infection with the mouse form of the malaria parasite.
The group therefore added a booster shot to the vaccination regimen. Animals that had been immunized with YF17D-CSP, or with a saline solution control, were given a low dose of irradiated sporozoites. While the saline-sporozoite group was only partially protected from challenge with viable parasites, vaccination with YF17D-CSP plus the sporozoites protected 100 percent of the animals against infection.
"These results are exciting because they show the YF17D-CSP vaccine can prime the immune response against a malaria parasite," says lead author Cristina Stoyanov. Although the utility of this approach for human immunization is not yet clear, the team hopes that further studies in other animal models might eventually lead to an effective vaccine.


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Interrogating the Norms: Women Challenging Violence in an Adversarial State
This book discusses how the women's movement in Pakistan started addressing/addresses violence against women. Chapter 1 is based largely on a narrative account of the Zia government, the underlying politics of Islamisation, the factors that led to the formation of Women's Action Forum and the ways in which the overall political environment influenced its work. Chapter 2, which is more sharply focused on the history of the women's movement, is more analytical and deals with the centrality of violence against women to the work of the women's movement, even though the term itself is still not in use. The emphasis here is on the link between the so called Islamic laws and what was still referred to as 'crimes against women'. It analyses the strategies adopted to challenge these laws, create public awareness on women's issues and the growing realization for the need for alternative safe spaces for women, such as shelters. Chapter 3 speaks about different women's organisations which, with the exception of Shirkat Gah and AGHS Legal Aid Centre, grew out of WAF in order to facilitate and deepen the work undertaken from the WAF platform or bear witness to WAF's growing credibility among predominantly left or liberal groups.


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The ORT school system will not fire Adam Verta, the civics and the philosophy teacher at the ORT Greenberg High School in Kiryat Tivon near Haifa, following the rally of support from human rights organizations and many of his own students. Verta came under attack after expressing criticism of Israel Defense Force behavior and support for Palestinian rights during a 12th grade civics class.
After the classroom discussion, a student sent an open letter of complaint to Education Minister Shai Piron about Verta's comments. Former Knesset Member Michael Ben-Ari, known for his radical views, then posted the student's comments on his Facebook page. In the wake of the controversy, the school sought to fire Verta.
Veteran NIF grantee Association for Civil Rights in Israel (ACRI) protested the dismissal attempts to Education Minister Shai Piron. Sharaf Hassan, Director of ACRI's Education Department wrote: "If teachers don't feel that the classroom provides a safe space and the freedom to deal with essential questions, then schools will have abandoned the vision and even the dream of being an influential factor in society."
Civil rights lawyer Michael Sfard represented Verta in a hearing before ORT management, persuading them that the teacher should keep his job. Sfard pointed out that his " client broke no Education Ministry instructions and this affair reeks of political persecution."


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Some extended excerpts:
We have two main ways of personalizing your Google experience. First, you can customize products and services like the Google Personalized Homepage. Personalizing your homepage gives you the at-a-glance information that you care about -- such as your latest Gmail messages, news headlines, or to-do list -- right at your fingertips, just the way you want it.The change, as described on this Google help page, is that anyone who signs up for a Google Account will be given a search history, a personalized home page, and individually personalized search results based on their past behavior.
Second, we offer automatic personalization through things like personalized search and recommendations. Our goal with these types of technologies is to make your Google search experience better based on what we know about your preferences, without you having to do any extra work.
Today, we're taking another step toward making personalization more available to you by combining these two into a single signed-in experience. Now, when you're signed in, you'll have access to a personalized Google -- one that combines personalized search results and a personalized homepage.
Keep in mind that personalization is subtle -- at first you may not notice any difference. But over time, as the search engine learns your preferences, you'll see it. For example, as an avid Miami Dolphins fan (no joke), searching for [dolphins] gives me info about my favorite football team, while a marine biologist colleague gets more information about her salt-water friends.
Before, everyone had to explicitly enable search history and personalized search to get those features, so very few did. This change of the default will mean that many more people, anyone who has used a feature that requires a Google account, will see personalized web search results and the other personalization features when they go to Google.
See also Danny Sullivan's detailed review of the Google personalization features and his thoughts on the impact of making them more easily and widely available.
See also Eric Schmidt and Larry Page's comments on personalization from their recent Q4 conference call.
See also some of my previous posts ([1] [2] [3] [4] [5]) on Google's personalization.
See also my earlier post, "Potential of web search personalization".


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The recent death of the lead singer of Yothu Yindi, is a high-profile example of an event all too common in Aboriginal Australia.
Older Aboriginal Australians (40 to 60 years old) are more than 15 times more likely to die of kidney disease than non-Aboriginal Australians. This is an age that's normally the prime life. But not only is it a tragedy for the individuals involved but has a much wider effect on the community.
Elders in all communities are a repository of knowledge and of accumulated wealth. Early death of key older family members deprives younger community members of the benefit of accrued knowledge of culture and both financial and social support.
The structure of the broader Australian population is like a pillar with similar numbers of people in all age groups. This means that a young non-Aboriginal child will often receive support and guidance from two mature adults with back up from four, still-living grandparents.
The population structure in Aboriginal Australia is quite different and is more like a triangle, with many more children than adults and even fewer living grandparents. This means that an Aboriginal child receives support and guidance from far fewer adults.
This pyramid like structure is generated partly by early death of Aboriginal adults from heart disease, diabetes and kidney disease.
Not a great start
Heart disease, diabetes and kidney disease are non-communicable diseases that are strongly influenced by the environment. Increasing evidence suggests that all three begin as the baby is developing in the uterus. This concept is known as fetal programming or the developmental origins of adult health.
Let us explain by using kidney disease as an example to illustrate the concept. Skin sores can become infected with the bacteria known as streptococcus, this type of infection can lead to kidney damage known as glomerulonephritis. This can happen in childhood, and, if it happens to a girl, her kidneys may already be damaged by the time she becomes pregnant.
Studies in pregnant sheep have demonstrated that if the mother's kidney function is damaged, then the kidneys of the developing fetus also become damaged. This allows kidney damage to be passed across generations.
Studies by others suggest that this is happening to many Aboriginal mothers and their babies. Aboriginal mothers often have evidence of kidney disease already present during pregnancy and Aboriginal babies are frequently born with a much smaller number of nephrons (the functional units of the kidney). Typically around 400,000 while non-Aboriginal babies have over one million.
This reduction in nephron numbers is linked to impaired growth within the uterus of many Aboriginal babies who are born too small (known as growth restriction), twice as often as non-Aboriginal babies.
A better way forward
If we are to close the gap in Aboriginal life expectancy and well-being, we need to focus on the beginning of life inside the uterus. We need to ensure high quality care and support for Aboriginal mothers and their babies.
We need to develop ways of identifying babies at risk of kidney disease early to prevent deterioration of kidney function that could be transmitted across generations into the future.
Progress is being made. In Tamworth, a research team from the University of Newcastle's department of rural health is recruiting young Aboriginal mums and their children and seeking to identify markers of kidney impairment in urine samples.
In Townsville, a neonatologist is using retinal photographs of newborn babies' eyes to identify those at risk of kidney disease (the blood vessels at the back of the eye reflect the way the blood vessels in the kidney are also developing).
If we can reduce the burden of kidney disease, we can improve not only the health of Aboriginal Australians but also their cultural and material wealth by allowing more older Aboriginal people to transmit their knowledge and resources to the next generation. Intervening early in life to optimise health is a much more effective strategy than trying to correct accumulated damage in later life.
Acknowledgement: Della Yarnold also contributed to this article.


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Karina Rodini shows extreme growth on her thighs and hips at her home in Sao Paulo, Brazil.
Add to Lightbox DownloadEXCLUSIVE: By Sanjay Pandey and Supito Maity in Sao Paulo A 28-year-old Brazilian woman crippled by sheer weight and disproportionate size of tumours in her lower limbs is pleading for help from the netizens. Karina Rodini, who was fired from her job and is forced stay unmarried due to her medical condition, says the disease took a heavy toll on her personal and professional life. Karina has spent most of her adult life hiding it in public. But after last year's botched up surgery in a state-run hospital, her 'legs have become double the size and no clothes fit her', making her a pariah in the locality. Karina suffers from type one neurofibromatosis, a genetic condition marked by changes in skin colour and the growth of non-cancerous cysts in different parts. The disease affects one in 4000 people globally. According to the US National Library of Medicine, patient with type one neufibromatosis are born with one mutated copy of the NF1 gene in each cell. It said, "In about half of cases, the altered gene is inherited from an affected parent. The remaining cases result from new mutations in the NF1 gene and occur in people with no history of the disorder in their family." Karina, from Sao Paulo, was just two when 'coffee milk' patches started to appear on her skin. She said due to the lack of formation of lumps, the doctors could barely make out what ailed her. "I was diagnosed with neurofibromatosis when I was only two years old, at first it was only 'coffee milk' patches so the doctor couldn't do anything because there were no lumps or tumours," she said. The cysts started to show up almost nine years later. One year later, when she was 12, Karina underwent a surgical procedure to remove a cyst, weighing around nine kilograms, from her uterus. According to her, the cavity gave her a semblance of a pregnant woman. Being the oldest child among three, Karina has always received love from her mother, Fatima M. Abou Ali, 58, a single woman, who raised
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Karina Rodini 28-year-old Brazilian woman surgical procedure last year medical condition daughter full-time Brazilian woman oldest child Fatima M. Abou Ali whole year single woman amount of her blood loss CT scan Sao Paulo personal life crowd-funding campaign massive tumours waist down US National Library of Medicine health condition public last year Newslions Media good position youngest sister Karina plastic surgeon boy's treatment necessary money menial jobs 28-year-old doctor removes 16-year-old boy available documents of Karina half of cases similar case doctor's appointment Brazilian cities cancerous cysts doctors genetic condition professional life requirement of frequent leaves skin colour coffee milk' patches lower limbs face of earth Brazil's largest city old skirt good doctor job Dr Ashwini Dash http://gf.me/u/qd9mpr). Karina disproportionate size of tumours lack of formation of lumps onus of the doctor hunt help adult life whopping amount heavy toll surgery procedure doctor daughters India semblance of a pregnant woman amount of blood Patricia ailment mother procedures touch different parts international news agency money employees cure undergraduate programme link normal life generic healthcare disease nobody Fatima company Patria cases result type times shortness of breath shoulder of Patricia choice changes night care love hospital treatment people legs problem area dermatologist Brazil Sanjay Pandey Curitiba Supito Maity Newslions Indore Canada Karolina three years four years two years 28-year milk nine kilograms 20 minutes nine years 500 grams One year 16-year 1 kilo
- Contained in galleries
- Karina Rodini shows extreme growth on her thighs and hips - 3 Feb 2019


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Israel May Strike Ship Allegedly Carrying Iranian Rockets To Gaza
By RT
Israel has reportedly vowed to destroy rockets and other weapons being sent to Gaza by Iran. Tel Aviv issued this threat despite a recent ceasefire following eight days of bitter conflict between Gaza and Israel.
Israeli spy satellites spotted a cargo vessel in the Iranian port of Bandar Abbas that was allegedly Gaza-bound and carrying arms, the Sunday Times reported.
"Regardless of the ceasefire agreement, we will attack and destroy any shipment of arms to Gaza once we have spotted it," an Israeli defense official told the newspaper.
The vessel reportedly began its voyage last week just as Israel and Hamas agreed to a ceasefire ending eight days of violence in Gaza, in which over 150 Palestinians died. The cargo is believed to include Fajr-5 rockets, similar to those used by Hamas in the conflict, and Shahab-3 ballistic missiles.
The ship is set to travel through the Red Sea, Sudan and Egypt, according to the Sunday Times report. The newspaper also cited Israeli officials speculating that Iran could be moving longer-range ballistic missiles into Sudan, which could be aimed at Israel from the African country.
The Sunday Times' report comes a day after the Hamas leadership announced they aren't ready to stop arming themselves, despite the recently-agreed truce and ceasefire.
"We have no choice but to continue to bring in weapons by all possible means," senior Hamas leader Mahmoud al-Zahar told reporters, adding that he expected Tehran would "increase its military and financial support to Hamas."
Earlier on Wednesday, exiled Hamas leader Khaled Meshaal thanked Shia-majority Iran for what he described as arms and funding.
On Saturday, Iranian President Mahmoud Ahmadinejad expressed support for Gaza in the bloody conflict, praising what he called Palestinian "resistance and perseverance" against Israel, which he said must now "bow" to Palestinian rights, IRNA news agency reported.
The eight-day Israeli assault on Gaza killed 168 Palestinians, mostly civilians. It also led to $300 million in economic damage, a Palestinian Chamber of Commerce report said.
Hamas fired Fajr-5 rockets against Israel, an unsettling revelation for the Israeli public. The country was last targeted by the 3-meter-long missiles during its 2006 war with Lebanon, and was expecting smaller-range rockets to be used in the recent conflict.
Hamas' Farj-5 arsenal was able to strike Tel Aviv and Jerusalem, cities that were not attacked during the previous escalation of violence between Israel and Gaza in 2008. The IDF was forced to rapidly deploy an additional battery of its Iron Dome air defense system to counter the threat.


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Strong and durable, the rubber used to make tires has many uses long after the tires are no longer fit for the road. Unfortunately, more than 290 million tires are dumped or tossed into landfills each year in North America alone. If only more people completed brilliant recycling projects like these 25 examples – including jewelry, flooring, shoes and entire houses – we could slash that figure significantly.
(images via: recaptured charm, lattices)
Stack tires and fill them with earth to make simple raised planters that cost next to nothing; the heat absorbed by the black rubber helps plants like potatoes and tomatoes thrive. Another idea hangs tires on a vertical surface, filling just the bottom portion with soil, to create unusual wall planters.
Rugs & Floor Mats
(images via: we upcycle, retiredmats)
Both vehicle tires and bicycle inner tubes can be transformed into durable, waterproof, non-slip surfaces for indoor and outdoor applications. Etsy seller ReTIRED Mats weaves strips of reclaimed tire rubber around metal frames. Bicycle inner tubes, as demonstrated above, is even flexible enough to crochet.
Says crafter Michaela, "After several attempts I found out that it's the easiest way to use a tent peg. I cut out the valves and then slit the tubes lengthwise. Washing the tubes has to be done thoroughly because the valves are covered in a thick layer of powdered talc from the inside. Then you have to cut the tubes in stripes and either tack (like I did it) or sew them together. The result is a long "thread" which you just crochet and then you're done."
Jewelry & Belts
(images via: trilliumartisans, julienjaborska, madeforfun, craesnyderindustries, andrewdietch)
Earrings, bracelets and belts get a tough urban look from recycled tires, even when used to create delicate leaf shapes and folded layers of ribbon. As belts, bicycle tires are still recognizable, perfect for cyclists who want to display their love for riding to the world.
Bike Stand
(image via: recyclart)
Tires were half-buried in the ground to make this clever and convenient recycled bike stand. With this simple solution, the bicycle's tire could be locked to the tire in the ground to secure it.
Parquet Flooring
(image via: apokalupsabotek.se)
Who would have thought that recycled tire flooring could be so stylish? Swedish company Apokalyps Labotek takes some of the 4 million tires that are disposed of in that country each year and grinds them into a powder, which is then mixed with recycled plastic and formed into flooring.
Bags & Wallets
(images via: trigo, blowuponlinevintage, rubberpieces)
It would take an awful lot of abuse to break or puncture a purse or wallet made out of reclaimed tire rubber, so these bags should last virtually forever. Etsy sellers Trigo, BlowUp Online Vintage and RubberPieces show just how versatile this material can be.
(images via: inhabitots)
Of course, tire swings are nothing new, but they're no longer just as simple as screwing on some bolts and chain. Check out these incredible creature-shaped tire swings that practically double as garden art. Wildlife Creations cuts and bolts tires into dragons, sharks, horses, dogs, elephants, dinosaurs and more.
(images via: maryland environmental service, inhabitat)
Animal-shaped tire swings are awesome, but what happens when you decide to make an entire playground out of reclaimed tires? With some creative thinking, the possibilities are practically endless. Two examples include a fun scrap tire dragon in Maryland, and a 'Rubber Tree' design by AnneMarie van Splunter installed in Thailand for refugee children.
(images via: simpleshoes.com, instructables)
All of the qualities that make rubber tread ideal for tires also make this material perfect for the soles of shoes. The shoe company Simple Shoes includes reclaimed tires in many of their eco-friendly designs. You can also make your own hand-crafted recycled sandals from a bicycle inner tube and a scrap of used tire, as explained at Instructables.
(images via: wallacegardens, bikefurnituredesigns)
Furniture made from reclaimed tires and bicycle wheels ranges from elegant and modern to funny and kitschy. The Tired Lounge chair by Leo Kempf weaves strips of tire rubber into upholstery for a rocker, while Bike Furniture Design comes up with crafty uses for practically every part of the bike – including, of course, the tires.
Roof Shingles
(images via: useitagain.soup.io)
You can now purchase commercially fabricated roof shingles made from recycled rubber – or you could go DIY like this ambitious homeowner, who cut strips of tires and arranged them into interesting patterns on his roof.
(images via: duncankinney, greendiary)
Tires are a central component of earthships, which are sustainable, self-sufficient homes made of recycled materials. Packed with dirt, the tires often form the foundation and walls of these free-form houses. Reclaimed tires can also be used as extremely inexpensive building materials . Argentine architect Carlos Levinton designed dome houses for Haitians displaced by the 2010 earthquake that devastated the Caribbean nation.
Sculptures by Yong Ho Ji
(images via: scrappedcraps)
Korean artist Yong Ho Ji has gone above and beyond all of these innovative re-uses for old tires with a sculptural series that binds strips of used tires together with synthetic resins. His complex works, depicting humans and animals, makes a statement about humanity's responsibility for nature.


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SARcode Bioscience, Inc., a privately-held biopharmaceutical company, announced today that the initial patient has been enrolled in the company's pivotal Phase 3 clinical study (OPUS-1) of SAR 1118 ophthalmic solution.
SAR 1118 is a first-in-class molecule that inhibits T-cell inflammation by blocking the binding of two key cellular surface proteins (LFA-1 and ICAM-1) that mediate the chronic inflammatory cascade. SAR 1118 may be able to reduce inflammation associated with dry eye disease.
The OPUS-1 trial will study the safety and efficacy of SAR 1118 in the treatment of dry eye disease. Approximately 588 patients will be randomized to receive SAR 1118 5.0% ophthalmic solution or placebo twice daily over 12 weeks. The co-primary endpoints of the study are corneal fluorescein staining score and visual-related function score (reading, driving at night, computer use, and watching television) as measured by the Ocular Surface Disease Index (OSDI), a validated instrument designed to assess the impact of dry eye upon vision-related activities. The safety and tolerability of SAR 1118 compared to placebo at 12 weeks will also be evaluated.
The OPUS-1 study aims to replicate the positive results observed in the Phase 2 dry eye trial, which demonstrated increases in tear production as early as 2 weeks, an improvement in corneal staining, and better visual-functional outcomes in the SAR 1118 treatment groups compared to placebo,said Charles Semba, MD, Chief Medical Officer.Initiating patient enrollment in our Phase 3 trial is a significant milestone for SARcode Bioscience as we continue to progress towards our goal of making this therapy commercially available to millions of dry eye sufferers.
Dry eye is an extremely common and significant problem encountered by eye care professionals,commented Edward Holland, MD, a cornea specialist from the Cincinnati Eye Institute and consultant to SARcode Bioscience.It is exciting to see this new molecular entity, which was specifically designed for ocular use, enter pivotal trials. If the Phase 3 program is successful, this novel therapy will provide a much needed treatment option that not only alleviates the symptoms of dry eye, but also improves visual-related quality-of-life for patients suffering from this disease.
SARcode Bioscience anticipates completion of the OPUS-1 study and topline data in mid-year 2012.
Dry eye disease is a prevalent and often chronic condition estimated to affect approximately 20 million people in the US. This number is expected to grow substantially in the next decade due to an aging population and increased incidence of type 2 diabetes, both of which contribute to higher rates of this condition. Dry eye disease is among the most common disorders treated by ophthalmologists throughout the world, and has been shown to have a significant impact upon quality-of-life. Dry eye varies in severity and etiology, and symptoms most commonly manifest as discomfort, visual disturbances, and tear film instability due to decreased quality or quantity of tears. A major contributing factor towards the development of dry eye is inflammation caused by T-cell infiltration, proliferation and inflammatory cytokine production that can lead to reduction in tear film quality and ocular surface damage.
SAR 1118 is a potent novel small molecule lymphocyte function-associated antigen-1 (LFA-1) antagonist under investigation for a broad range of ocular inflammatory conditions including dry eye and diabetic macular edema. LFA-1 is member of the integrin family of adhesion receptors found on the surface of all leukocytes and represents a therapeutic target central to a number of inflammatory stimuli. SAR 1118 has demonstrated potency in blocking LFA-1 binding to its cognate ligand, intercellular adhesion molecule-1 (ICAM-1), thereby inhibiting cell adhesion, cytokine production, and cellular proliferation in in vitro models. In a Phase 2 trial randomized, placebo-controlled trial of 230 subjects with dry eye disease, SAR 1118 demonstrated significant improvements in both signs and symptoms of dry eye as early as two weeks. SAR 1118 was well tolerated and ocular adverse events were mostly mild, transient, and related to initial instillation of the drug.
SARcode Bioscience, Inc., founded in 2006, is a venture-backed ophthalmic biopharmaceutical company based in Brisbane, CA. SARcode Bioscience's lead development program is a novel class of lymphocyte function-associated antigen-1 (LFA-1) antagonists for the treatment T-cell mediated inflammatory diseases. Institutional investors include Alta Partners, Clarus Venture Partners, Rho Ventures and Sofinnova Ventures. www.sarcode.com
Media, Erin Parsons
email Erin


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7. Installing from scratch
ACPI is constantly being revised. It is available in later versions of the 2.4.x series kernel (2.4.22 and higher), and all 2.6.x series kernels. If you would like to use a kernel before 2.4.22, you will need to patch your kernel source to add ACPI functionality. If at all possible you should use the latest stable version of the kernel. Patches are available from acpi.sourceforge.net.
Red Hat Fedora Core 2 now ships with ACPI enabled by default! This is big progress for the ACPI development team. Congratulations to everyone.
Even the latest kernel will sometimes have minor bug fixes available as a patch. You should check the ACPI4Linux web site to see if there are any patches available. |
You need to get the patch that exactly matches the version of the kernel that you are running. Since this is the "install from scratch" section I will assume you know exactly which kernel you will be installing.
7.1. Choosing a kernel
This document was originally written for the 2.4.20 kernel and has been updated since to include information about the 2.6.x series kernels. At the time of this update the 2.6.x series kernels are proving easy for some and harder for others. (I personally cannot properly power down my computer with the 2.6.5 kernel.)
If you can, I would recommend waiting to upgrade your kernel to the 2.6.x series until more bugs are ironed out. There are a lot of changes in the 2.6.x series kernel. When I upgraded to 2.6.5 to update this document I ran into problems with my wireless connection, my nvidia graphics card, and with ACPI. Your mileage may vary. I personally had good success with the 2.4.20 with the latest patch and the 2.4.22 kernel with no patch. A Google through your distribution's mailing list, and the acpi-devel mailing list should help you to pick the right kernel.
This document uses the 2.4.20 kernel as an example for 2.4.x series kernels. Substitute your own kernel version as appropriate. |
Regardless of which kernel you choose, if it is a kernel that requires patching, it is important to use the latest version of the ACPI patch. Some distributions have already patched their kernels. This is the case for Debian, and may be the case for others. For more information on the patches that have been applied to the Debian kernel source package scan through: /usr/src/kernel-source-<version>/README.Debian. If you are not using Debian you will probably still be able to find an equivalent file for your distribution.
A user on acpi-support confirmed that I shouldn't need any of the additional patches that have been applied to the kernel to run my laptop. If you are running a production-level server and/or are serving web pages to the internet, you should really apply any additional security patches.
If a kernel has had other patches applied to it, you may have problems applying the ACPI patch. Of course, an ACPI patch should not be applied to a kernel that is already patched for ACPI. As long as there has not been an ACPI patch applied to the kernel it should be possible to apply one now. Depending on the patches applied, you may need to modify some of the Makefiles for your patch to be successful. This is beyond my current grasp of reality so it is not covered in this document. |
7.1.1. Debian-ized pre-patched kernel
If you would prefer to use a Debian-ized kernel instead of a fresh one, maxx has provided a pre-patched kernel-source package with the latest patch for the 2.4.20 kernel. This would be instead of downloading a fresh (non-patched) kernel from www.kernel.org. He sent me an email with the following details:
I took the kernel-source 2.4.20-8 from unstable, removed the ACPI changes [i.e. the old patch] and applied acpi-20021212-2.4.20.diff.gz from acpi.sf.net since the vanilla 2.4.20 HAS several security leaks (ptrace, hash table, ...). You can find the package at http://people.debian.org/~maxx/kernel-source-2.4.20/ (I didn't upload the .orig.tar.gz since you can get it from any debian mirror and the .deb is already big enough) | ||
--maxx |
I have not tested these packages. You may or may not have any luck with them. Please don't email me asking about them, ask maxx instead. |


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Great Lakes proving of TV emanation
The remedy was made in Toronto, Canada in December 2009 by exposing milk sugar placed in a porcelain bowl two feet in front of a 1985 Sony Trinitron Television that was left on for 48 hours.
The proving was conducted in Boston on November 6, 2010. There were four provers – one male, three female. There were three observer/supervisors. The full Great Lakes Protocol was followed.
Trituration Dynamics:
The provers sat like four lumps on the couch, moving very little, looking bored and blank. They only rose to tend the fire or to eat, obsessively rearranging the fire logs. The fireplace captured a lot of their focus and attention. They were largely uncommunicative and had to be prodded to share their experience. To the observers the scene appeared to be Mom and Dad and their two kids watching television in their living room. All four sat staring, quietly, not engaging in conversation. When conversation occurred, it was limited and somewhat superficial. One prover was very captivated by her iPhone throughout the trituration.
Television's impact on culture, connection and perception:
Television is a huge cultural force with wide-ranging impact. It has exerted a transformative influence on people and society. In the sixty years since television has become commonplace across the globe, this technology has revolutionized the way people see themselves and the world around them. People for the first time can have experiences far outside their normal possibilities, e.g. they could see what it was like to walk on the moon. TV also created great connection among people. Marshall McLuhan coined the phrase "The Global Village" which he felt described how television would result in "our planet's collective neural wiring creating a single 24-7 … meta-community."
Television has fundamentally altered human perception. What we see, what we understand and the way we feel our perceptions have been transformed. It has affected our beliefs, our behaviours and even our brain chemistry. Some medical studies suggest that when a person watches television, actual brain chemistry is affected and a hypnotic state is induced. Some researchers have attributed various autism spectrum disorders (ADHD, Asperger's) to the exposure to television. In particular Autism Spectrum features such as obsessive or repetitive routines and behavior patterns, preference for solitary activities, difficulties in social interaction and delayed or impaired language skills have been linked to childhood television-watching.
The Proving Themes:
Affected by a Force
In television, stories are told through images and the images are transmitted by a force which can either make powerful connections or alienate. One of the provers experienced this sense throughout the entire proving: "Whatever they were going to do [to me], they were going to do forcibly…"
Altered Perception
It enables us to see that which is far away, in other time periods and places. It can take us there and immerse us into lives and situations that we would otherwise never experience; things beyond our reach, transporting us through all of our senses.
Altered perception can also include the alteration of our needs and desires. Sociologists have discussed how television has amplified individual's desire for things and experiences typically not available to them.
Desire to open eyes wide
Television is about vision and perception. The cathode ray tube in a television has a similarity to the shape of the human eye. One prover stated several times "I feel like I have to open my eyes very wide - not only physically wide open but open up their perception as well."
Common Experiences /Camaraderie/Group Effort
Some provers and supervisors talked about group effort and camaraderie (or lack thereof) throughout the proving. Whole communities, neighbours and friends played a big part in the provers' dreams. There was the polarity between concern for the group "feeling a connection to the trituration circle and participants, as if we were a tribe sitting in circle around a fire" and one prover having her own very individual, non-interactive experience: "I feel like I cannot physically talk. But I am taking good notes for you all."
Being Entertained, Fame, Special
Sociologists and media critics have argued about the impact of viewing things, places and time periods that people would never experience in their lives. The experiential impact that television provides has resulted in many viewers having a difficult time distinguishing between their own lives and those they experience through TV. One prover said" I want to go down in history." She wanted her name to be recorded. Another had a dream: "… circus-like and on the beach; there are gymnastics, like a totem pole of naked young women standing with their feet on the shoulders of the one below."
Expand, Contract
The mass acceptance of television coincided with the period of the United States' post-World War II economic and political dominance. The "transmitters" of TV information are relatively few in number relative to the numbers affected by TV's impact. One prover stated "I feel inward, whereas before I felt expansive." This was seen in dreams and in the inward withdrawal several provers experienced.
Bored, Restless/Active, Calm
Provers wanted to engage but could not and were frustrated "I feel like this remedy will be good for someone who is like a lump on a log or someone who is restless, wanting to move and can't." Another prover felt that "There is always something to do. I have to do the laundry and then at 8 pm I should sit and watch TV but I don't; there is always something to do."
Uneventful/Nothing is Happening/Routine
All of the provers experienced a period where they felt nothing was happening. They expressed frustration with that feeling. "Not much of anything to report. Went to work, feel OK."
Sensitivity, Irritation
The symptoms here reflected the heightened senses that provers experienced during the proving (like the desire to open up the eyes wide). They were worse with movement, noise and light.
Directional problems and a feeling of disorientation also reflect the heightened senses (like sensitivity and wanting to open up eyes wide) that the provers experienced.
Numbers, Number 8
There were several instances involving specific numbers mentioned by the provers, particularly in dreams.
Physicals and Generals:
Hunger/No appetite
Better Fresh Air
Pressure better, feeling pressure (occiput), feel pulsating energy, need a release from pressure, energy in head wanting to go out, too much energy in head.
Head Pain
Slight headache, headache worse light, want to close eyes and rest/retreat. Headache worse motion. Pain left-hand side, across forehead. Migraine. Headache around third eye, better fresh air.
Want to open them wide, as though my eyebrows want to keep going up. Pulsation in eyes. Eyes feel relaxed. Watery eyes, heavy, sleepy eyes.
My peripheral focus is not the same. Eyesight heightened. Vision shimmery.
Running nose, watery coryza, tip itches, nose itches. Tingling nasal sensations better fresh air.
Heightened sense of smell as though the smell was in my nose.
Achy jaw, quivering facial muscles, need to rest my facial muscles.
Itchiness on roof of mouth and throat. Lips tingly and metallic taste in mouth. Lips feel cold, yawning helps me release.
Feel like I can't speak right now, feel I physically can't talk.
Noticed no plaque where there is usually something to scrape off.
External Throat
Discomfort around my trachea on the right side.
Constipation, larger than normal stool
Waking to urinate
Need for a lot of deep breaths. Feels like breathing is incredibly shallow. Breathing is getting deeper, like in meditation. Breathing slow and deep. Deep breaths help to release.
Feeling something not totally physical.
Neck hurts, out of alignment. Strained right shoulder. Itchiness around neck and head. Upper thoracic to neck loosened up, released tension.
Back, Pain
Pain lower back
Pain neck
Bruises on thigh, swollen left inguinal crease, sensitive to touch.
Slept well, fabulous sleep, uninterrupted. Woke up feeling horrible, didn't sleep well. Sleepy.
Itchy all over head and leg. Arm pits, knees and neck, face itchy, moving around.
The most striking aspect of this remedy is its wide-ranging alteration of perception. In the proving we saw perception shift from small to a very, very large field. This was seen in almost all of the proving themes—from the desire to be famous and special to being part of a bigger group, the changing ability to communicate, more basic issues with vision and wanting to keep their eyes wide open, the distortion of direction and heightened senses.
Extreme experiences ran throughout this remedy, outside the normal parameters of the provers' lives. This was especially seen in the provers' dreams. One prover described a sense of something coming over her and preventing her from expressing herself. Another prover's dream found himself in the midst of a dangerous situation watching super-human feats.
The 'overwhelming force' aspect of TV was also felt strongly during the collation and write-up of this proving. I found it extremely difficult to complete the process. There was a sense of the topic expanding - like an imponderable force. Information just kept growing and growing with no end in sight, as if it was too difficult to corral the information into a focused structure. This reminded us of the expansion and contraction aspect of the proving and of the shape of the cathode ray tube or the human eye.
The idea of collective or group experience that came through in the proving was also seen during the trituration processes: while the provers 'sat as lumps, largely uncommunicative', there were expressions for the need to communicate as a group. They repeatedly mentioned the idea of a common experience and a sense of responsibility to the group.
We could see this remedy being used for symptoms with extreme lack of emotional attachment, difficulty to express oneself or connect emotionally, a flatness or difficulty in communication and speech, obsessiveness with superficial or specific things, aspects of an Asperger's-like response. The person needing TV emanation might be inwardly focused, dull and bored, but with tremendous hope and desire to connect with others and have meaning. As one of the provers said during the trituration: "I feel like this remedy will be good for someone who is a lump on a log or someone who is restless, wanting to move and can't."
Thanks to the provers and to Pat Maher and Sally Williams for their great support. Thanks also to Lou Klein, who first proposed proving this substance and saw its potential impact. The entire proving can be read at www.greatlakesprovings.com. The remedy is available at www.helios.co.uk.
Carol Jones practices homeopathy in Toronto, Ontario, Canada.
Photos: Wikimedia Commons
Sony Trinitron TV; Daniel Christensen
TV and child; Aaron Escobar
Categories: Provings
Keywords: Homeopathy, proving, Asperger's, affected by a force, altered perception, Great Lakes Provings
Remedies: TV emanation


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Computer security experts are often surprised at which stories get picked up by the mainstream media. Sometimes it makes no sense. Why this particular data breach, vulnerability, or worm and not others? Sometimes it's obvious. In the case of Stuxnet, there's a great story.
As the story goes, the Stuxnet worm was designed and released by a government--the U.S. and Israel are the most common suspects--specifically to attack the Bushehr nuclear power plant in Iran. How could anyone not report that? It combines computer attacks, nuclear power, spy agencies and a country that's a pariah to much of the world. The only problem with the story is that it's almost entirely speculation.
Here's what we do know: Stuxnet is an Internet worm that infects Windows computers. It primarily spreads via USB sticks, which allows it to get into computers and networks not normally connected to the Internet. Once inside a network, it uses a variety of mechanisms to propagate to other machines within that network and gain privilege once it has infected those machines. These mechanisms include both known and patched vulnerabilities, and four "zero-day exploits": vulnerabilities that were unknown and unpatched when the worm was released. (All the infection vulnerabilities have since been patched.)
Stuxnet doesn't actually do anything on those infected Windows computers, because they're not the real target. What Stuxnet looks for is a particular model of Programmable Logic Controller (PLC) made by Siemens (the press often refers to these as SCADA systems, which is technically incorrect). These are small embedded industrial control systems that run all sorts of automated processes: on factory floors, in chemical plants, in oil refineries, at pipelines--and, yes, in nuclear power plants. These PLCs are often controlled by computers, and Stuxnet looks for Siemens SIMATIC WinCC/Step 7 controller software.
If it doesn't find one, it does nothing. If it does, it infects it using yet another unknown and unpatched vulnerability, this one in the controller software. Then it reads and changes particular bits of data in the controlled PLCs. It's impossible to predict the effects of this without knowing what the PLC is doing and how it is programmed, and that programming can be unique based on the application. But the changes are very specific, leading many to believe that Stuxnet is targeting a specific PLC, or a specific group of PLCs, performing a specific function in a specific location--and that Stuxnet's authors knew exactly what they were targeting.
It's already infected more than 50,000 Windows computers, and Siemens has reported 14 infected control systems, many in Germany. (These numbers were certainly out of date as soon as I typed them.) We don't know of any physical damage Stuxnet has caused, although there are rumors that it was responsible for the failure of India's INSAT-4B satellite in July. We believe that it did infect the Bushehr plant.
All the anti-virus programs detect and remove Stuxnet from Windows systems.
Stuxnet was first discovered in late June, although there's speculation that it was released a year earlier. As worms go, it's very complex and got more complex over time. In addition to the multiple vulnerabilities that it exploits, it installs its own driver into Windows. These have to be signed, of course, but Stuxnet used a stolen legitimate certificate. Interestingly, the stolen certificate was revoked on July 16, and a Stuxnet variant with a different stolen certificate was discovered on July 17.
Over time the attackers swapped out modules that didn't work and replaced them with new ones--perhaps as Stuxnet made its way to its intended target. Those certificates first appeared in January. USB propagation, in March.
Stuxnet has two ways to update itself. It checks back to two control servers, one in Malaysia and the other in Denmark, but also uses a peer-to-peer update system: When two Stuxnet infections encounter each other, they compare versions and make sure they both have the most recent one. It also has a kill date of June 24, 2012. On that date, the worm will stop spreading and delete itself.
We don't know who wrote Stuxnet. We don't know why. We don't know what the target is, or if Stuxnet reached it. But you can see why there is so much speculation that it was created by a government.
Stuxnet doesn't act like a criminal worm. It doesn't spread indiscriminately. It doesn't steal credit card information or account login credentials. It doesn't herd infected computers into a botnet. It uses multiple zero-day vulnerabilities. A criminal group would be smarter to create different worm variants and use one in each. Stuxnet performs sabotage. It doesn't threaten sabotage, like a criminal organization intent on extortion might.
Stuxnet was expensive to create. Estimates are that it took 8 to 10 people six months to write. There's also the lab setup--surely any organization that goes to all this trouble would test the thing before releasing it--and the intelligence gathering to know exactly how to target it. Additionally, zero-day exploits are valuable. They're hard to find, and they can only be used once. Whoever wrote Stuxnet was willing to spend a lot of money to ensure that whatever job it was intended to do would be done.
None of this points to the Bushehr nuclear power plant in Iran, though. Best I can tell, this rumor was started by Ralph Langner, a security researcher from Germany. He labeled his theory "highly speculative," and based it primarily on the facts that Iran had an usually high number of infections (the rumor that it had the most infections of any country seems not to be true), that the Bushehr nuclear plant is a juicy target, and that some of the other countries with high infection rates--India, Indonesia, and Pakistan--are countries where the same Russian contractor involved in Bushehr is also involved. This rumor moved into the computer press and then into the mainstream press, where it became the accepted story, without any of the original caveats.
Once a theory takes hold, though, it's easy to find more evidence. The word "myrtus" appears in the worm: an artifact that the compiler left, possibly by accident. That's the myrtle plant. Of course, that doesn't mean that druids wrote Stuxnet. According to the story, it refers to Queen Esther, also known as Hadassah; she saved the Persian Jews from genocide in the 4th century B.C. "Hadassah" means "myrtle" in Hebrew.
Stuxnet also sets a registry value of "19790509" to alert new copies of Stuxnet that the computer has already been infected. It's rather obviously a date, but instead of looking at the gazillion things--large and small--that happened on that the date, the story insists it refers to the date Persian Jew Habib Elghanain was executed in Tehran for spying for Israel.
Sure, these markers could point to Israel as the author. On the other hand, Stuxnet's authors were uncommonly thorough about not leaving clues in their code; the markers could have been deliberately planted by someone who wanted to frame Israel. Or they could have been deliberately planted by Israel, who wanted us to think they were planted by someone who wanted to frame Israel. Once you start walking down this road, it's impossible to know when to stop.
Another number found in Stuxnet is 0xDEADF007. Perhaps that means "Dead Fool" or "Dead Foot," a term that refers to an airplane engine failure. Perhaps this means Stuxnet is trying to cause the targeted system to fail. Or perhaps not. Still, a targeted worm designed to cause a specific sabotage seems to be the most likely explanation.
If that's the case, why is Stuxnet so sloppily targeted? Why doesn't Stuxnet erase itself when it realizes it's not in the targeted network? When it infects a network via USB stick, it's supposed to only spread to three additional computers and to erase itself after 21 days--but it doesn't do that. A mistake in programming, or a feature in the code not enabled? Maybe we're not supposed to reverse engineer the target. By allowing Stuxnet to spread globally, its authors committed collateral damage worldwide. From a foreign policy perspective, that seems dumb. But maybe Stuxnet's authors didn't care.
My guess is that Stuxnet's authors, and its target, will forever remain a mystery.
Bruce Schneier is a security technologist and the chief security technology officer of computer security firm BT. Read more of his writing at www.schneier.com.
See Also:
The Internet: Anonymous Forever
Google And Facebook's Privacy Illusion
McAfee And The Software Side Of Intel


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Plant a tree for Arbor Month and get up to $50 back!
Mar 28, 2013 at 3:36 PM 0 Comments
Speaking of trees, Monday April 1 is the start of Arbor Month, and this weekend is supposed to be beautiful weather. What better way to celebrate than planting a new tree (or three)! Remember you can get a Treebate credit on your stormwater bill for eligible new trees planted in your yard. Here's a direct link to the Treebate brochure and application form, or visit our website for more information: www.portlandoregon.gov/bes/treebate .
Find more information about local Arbor Month festivities on the Portland Parks and Recreation Arbor Day site.
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Product Details
Jeep Liberty 2009, Door Molding by Mopar®. This product is made of high-quality materials to serve you for years to come. Designed using state-of-the-art technology and with customers in mind, this product by Mopar will last a lifetime. It will meet your needs and deliver great quality at an affordable cost.
- Expertly crafted from premium materials
- Designed to match rigorous quality standards
- High quality at a budget-friendly price
Mopar is here with excellent products that are available at a competitive price. The company does its utmost to provide the best possible solutions for your needs. All products by Mopar are made with expert care and created by professionals to meet all your requirements. The company does not accept compromises when it is going about quality, so you can be sure that all products have only first-rate. quality. With many years of manufacturing experience, Mopar is the name you can trust.
Mopar® is an exclusive source for original equipment parts and accessories for millions of Chrysler, Dodge, Jeep, Ram, and Fiat vehicles. For over 8 decades, professional technicians, racers and weekend drivers worldwide have used Mopar products for vehicle repairs and maintenance. Its authentic engine, drivetrain and transmission parts along with cooling system components can be found in thousands and thousands of vehicles crisscrossing the country and the world. Mopar parts and accessories are all you need to keep your vehicle looking and performing at its best.


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The Sky Comes Closer in Northern Chile
Inauguration of new educational activity supported by ESO
20 October 2010
The Sky in our Hands (El Cielo en Nuestras Manos) is a new educational activity offered by the Cruz del Sur public observatory (Southern Cross Observatory), a popular tourist destination located near Combarbalá, in the Region of Coquimbo in Chile.
The activity, which is intended for primary school children, consists of a new educational video entitled Laura Estrella (Laura Star), as well as printed materials and paper models for practical workshops. In the video, a little girl named Laura dreams of a space voyage where she — guided by her mother — discovers some secrets of the Universe, from planetary motions to the shape of our own galaxy, the Milky Way.
The project also included the development of practical exercises and games, which are available from the Southern Cross Observatory.
The Sky in our Hands was supported and financed by the European Southern Observatory, through the ESO–Chilean Government Joint Committee 2009. Two other tours, entitled Chile, a Window to the Universe, and The Sun's Children, are also offered by the Southern Cross Observatory, and were supported by the same fund in 2007 and 2008 respectively.
The Sky in our Hands had a preliminary run for the 200th anniversary of the Republic of Chile in September 2010 and was officially inaugurated on 12 October 2010.
- Visit Southern Cross Observatory website (Spanish only): http://www.observatoriocruzdelsur.cl
- Educational material from Southern Cross Observatory
More Information
Since 1998, the ESO–Government of Chile Joint Committee has financed postdoctoral fellowships and positions for astronomy professors at Chilean universities, infrastructure development, conferences, training for science teachers at primary and secondary levels and astronomy outreach programmes for the general public.
Valentina Rodríguez
European Southern Observatory
Santiago, Chile
Tel: +56 2 4633123
Email: firstname.lastname@example.com
Lorena Díaz Salinas
Southern Cross Observatory
Combarbalá, Chile
Tel: +56 53-741854
Cel: +56 9 82596984
Email: email@example.com
About the Announcement
Id: | ann1074 |


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The city requires owners to submit an annual Rental Registration application.
Show All Answers
A permit is required for construction, addition, alteration (altering the structure with walls, beams, etc.), remodeling, replacement (hot water tank, furnace, AC unit), and demolition. A separate permit shall be obtained for signs, electrical work, plumbing work, heating appliances and any other equipment installation that is regulated by the Building Code.
A homeowners permit can be pulled for general construction such as roofs, decks, siding, concrete etc. All other trade permits must be pulled for electrical (except power restoration), plumbing, HVAC, and fire by licensed contractors. The homeowner who obtains their own permit is considered the contractor for the project and is responsible for making sure that all work is in compliance with applicable codes and ordinances and that all inspections are scheduled before work is concealed. All subcontractors must be registered with the city.
The city does not recommend or endorse contractors but we do maintain a list of all registered, licensed and bonded contractors for all trades.
A permit is valid during the course of construction. If work is delayed or suspended for more than 6 months, or if the project is not completed within 1 year after issuance, then your permit approval is invalid. The city may grant one or more 90 day extensions of the permit if good cause is shown in writing.
It is suggested one should seek legal advice.
New permits are required to be secured by the new contractor. The cost of any new permit(s) is dependent on the level of completion. Upon request, the city will perform an inspection to record the progress and scope of work completion.
Contact the Building Department at (216) 587.1230 or stop in the Building Department located at 4743 Richmond Rd. 8:00 a.m. – 5:00 p.m. Monday-Friday.
The city requires owners to submit a Certificate of Occupancy application for inspection prior to the dwelling becoming occupied.
Owners must submit a Commercial Business Occupancy application for inspection prior to the business becoming occupied.
The city does not allow a business to be operated out of a home with the exception of licensed Type B Daycares and Group Homes.
A point of sale application must be submitted for inspection for both residential and commercial properties prior to the transfer of ownership.
The requires a hold of 150% for any outstanding violations not corrected prior to the transfer of ownership.
Yes, grass or noxious weeds 6" or more constitutes a violation.
The city does not allow any person to park, store or permit any trailer, manufactured home, recreational vehicle or similar conveyance to stand or remain upon any property in the city, except if it is kept in a garage or other similar and suitable structure upon such premises.


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Seriously intriguingly good chili |
I'm not going to lie. When my hazel-hued eye orbs made contact with Homestyles Beef Chili with Beans, two things immediately jumped out at me. That golden, sun yellow, fun, yellow, heavy box of ready-to-serve beef chili looked a little too good to be true: First, how in the heck can something with that much meat be shelf stable, and secondly, how's a shelf-stable, beef-based chili going to taste?
A quick peek at the label (picture below) and I was surprised to see that nothing in terms of ingredients jumped out at me and shrieked scary thoughts as a shelf-stable meat product–at least not what I'm accustomed to seeing in terms of polysyllabic latinates. From tomato puree, to ground and diced beef, to black soybeans, green pepper, textured vegetable protein (soy), and spices (and a small amount of oat product), the product is about what the average low carber would produce in their own kitchens. Pretty legit.
Click to enlarge |
But, again. How does it taste?
With black soybeans playing the part of the starchier black beans, Homestyles chili was surprisingly delicious, and precisely what one might expect from a quality, commercial chili. Spicy, with notes of chili powder, cumin, pepper, and nightshades, the chili is thick, filled with both ground beef and chunks of beef that promise (and deliver) terrific texture and flavor. And again, I say–from a shelf stable product.
Look at this gorgeousness |
David, from Homestyles, even had this to say: The unique packaging is done in a highly sophisticated USDA-inspected plant in Oregon. They really helped us deliver this recipe with all the goodness we could imagine. Nice!
And at only 4 net carbs for each ample, 10 ounce serving, and at less than $3, this is definitely a more economical choice in terms of travel for business, camping, work or for school–and especially since it's shelf stable.
To serve, microwave by lifting one corner of the plastic flap and allow to cool slightly; or, if you're at home, pour contents into a pot, heat and serve. Heck, you could eat it at room temperature, right out of the box, which makes it perfect for transporting places you don't have access to a refrigerator.
And because the flavors and textures are so spot on, there's no reason to tell the kids they're eating something low carb, is there? Didn't think so. They'll never notice.
Homestyles Beef Chili with Beans
Rating: ♥♥♥♥♥
Price: $2.69 10 oz. container
Bonuses: Only 4 net carbs, 250 calories, shelf stable, meat and chili have great texture and taste
Usefulness: For travel, work, school lunches, camping, anywhere refrigeration isn't an option
Negative: Contains soy, for those with an aversion, and a wee bit of oat product
Found: Store Locator
Website: Link
Disclosure: This product was not provided free of charge for review, and has not affected my opinion of the stuff.


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The controversial SeeDealerCost.com website has attracted 23,000 unique visitors and 250,000 page views since it went live March 17, according to the company.
Traffic has come from 88 countries and the site is ranked at 116,788 in the United States by Alexa.
"See Dealer Cost is not a selling site, but instead provides product information, including prices, features and specifications," company spokesman Dave Taylor said in a statement.
"Site users are able to configure products and save configurations in their account or print them out. In addition, a wide range of supportive information is available, including financing, insurance, relevant articles and pre-owned value information," he added. "For participating companies, See Dealer Cost is a lead generation and/or advertising site."
Soundings Trade Only left messages last week for some of the site's marine advertisers, but the calls were not returned.
The company said it has received many complimentary comments, including:
Soundings Trade Only has received more than 150 comments about the site, many of them from people in the marine industry who are concerned that it will hurt their business. The main concern is the inclusion of the dealer's cost of a boat vs. the manufacturer's suggested retail price.
Phil Keeter, president of the Marine Retailers Association of America, previously told Soundings Trade Only that the price on a dealer's invoice does not include what happens to the boat at the dealership to prepare it for sale. Also, he says, there is no set invoice cost for every dealer of a specific brand. The price can be determined by many factors, including the volume that the dealer does with the manufacturer.
J&D Acquisitions said last week that it had filed suit against the site, arguing that the use of its contractual and proprietary pricing information "will damage our brands and our dealers and we will not stand for it."
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Slackware Banners, Logos, Propaganda:
Send all others, mutations, edits, URLs, Info to
Any questions? Read the
Slackware Propaganda Graphics FAQ
I am looking for either a platform / site elsewhere where we can run the Propaganda pages to make submissions and acceptance/categorization/uploading of submissions easier, and/or a script or code that we can run here that will do so. There are plenty of submissions that have been sent in that I just have not had the time to sort through and place here. All suggestions welcome.
Logo Edits from Marek Stepien
Banners from
The following are two clever takes on Slackware's version of Tux, that being with a traditional tobacco-type pipe in his bill (mouth), however the pipe in Tux's bill really isn't reflective of smoking either tobacco or illegal drugs. These are here however, because they are rather creative and well done Slackware graphics parodies.
Logo for Unofficial Macintosh PPC port of Slackware called
Dated Slackware Graphics: (Any graphic which has a version number in it)
The Smiling, Grinning, Humanoid Pipesmoking face is J.R. Bob Dobbs and is Trademarked by the
The SubGenius Foundation
, as opposed to the Smiling, Grinning, Pipe-smoking Penguin face, which is Slackware's version of Tux. Slackware and the Slackware logo are Trademarks of Slackware Linux, Inc. Other Logos and names are trademarks of their respective companies, or organizations. (Such as Apache/the Apache Feather, and AMD.)
Please note: neither this page nor I officially represent Slackware in any way.
Go back to
MSimons' Pages and Projects


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I found this online today and think that it just might be what I've been looking for. It only weighs 4.4 ozs a
nd stores 4400 mAh at 3.7volts. It also provides 6 volts and 8.4 volts as well for devices that need more voltage.
It has about 30 tips to connect litererally hundreds of devices. I takes about 3hrs to charge from the wall socket or about 4hrs from USB. This is great for me because I could leave yet another wall wart at home and just plug in my laptop and charge it with that. Then when I'm out on a plane or train I could use it to power other things. I'm not sure it would help with my camera because my current one relies on batteries but in the future maybe.


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HTC Desire Z: what you need to know
HTC Desire QWERTY jigsaw pieced together
Update: read our Hands on: HTC Desire Z review.
Capitalising on the success of the HTC Desire, HTC is bringing out two new Desire-branded Android phones - the HTC Desire HD and HTC Desire Z.
The phone that would become the HTC Desire Z was first unearthed back in May, when an HTC model described as the HTC Vision was mentioned in an HTC device profile - a codename that didn't make much sense, given that the leaked phone was said to be an HTC Desire with a QWERTY keyboard attached. What's "Vision" about a keyboard?
Proper confirmation of the HTC Vision was then gained on July 5, with a handful of spy photos of a test handset appearing online. And yes, it is indeed the long-awaited HTC QWERTY Android phone.
HTC Desire Z specifications
This leak also gave us our first look at the HTC Desire Z specs. The HTC Desire Z's screen is the same size as that of the non-QWERTY HTC Desire, giving us 3.7" of touch space, powered by the same swift 1Ghz processor.
This early version of the handset was running an unskinned version of Android 2.1, leading some to suspect this images was a fake. But it wasn't. And we expect HTC to fully skin the phone with its HTC Sense UI in time for the HTC Desire Z release date.
The most recent twist in the HTC Desire Z saga landed on August 16 when we saw the official name of the handset appear online, via an embarrassing early product listing on Amazon, while the most recent unofficial HTC Desire Z mention came on August 20, when retailer Mobiles.co.uk stuck up a listing for the Android phone on its site.
The page apparently confirmed all the HTC Desire Z tech specs - 3.7" screen, 1GHz processor, full QWERTY keyboard and, slightly disappointing if true, Android 2.1 as its onboard OS at launch.
The same Mobiles.co.uk update also confirmed HTC's other re-imagining of its renowned HTC Desire - the HTC Desire HD. Both have been removed from the site's directory at time of writing, though.
Oh, and US readers beware – HTC is planning on launching the Desire Z as the HTC Blaze, or possibly the G1 Blaze in the States.
HTC Desire HD specs and speculation
The HTC Desire HD also has a confusing history of leaks. The phone first appeared under the name HTC Ace, and its 4.3" screen led us to expect a rebranded HTC EVO.
The Desire HD has been pictured and even appeared on a leaked video, showing a phone that actually has a similar streamlined form factor to the top-scoring HTC Desire.
The thing that's "HD" about the HTC Desire HD is the Android phone's screen, which echoes that of the US-only HTC EVO - measuring an enormous 4.3".
We're expecting official confirmation of both the HTC Desire Z and HTC Desire HD to arrive in a couple of weeks, when HTC shows off its upcoming smartphone range in London on September 15.
We'll be back with an HTC Desire Z review as soon as possible.
Liked this? Then check out HTC Desire HD: what you need to know
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