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Dirty air is bad for everyone. Linked to higher risks of heart attacks and strokes in adults, air pollution from highways, industrial factories and wood smoke has even been found to cause behavioral problems in children born to mothers with high exposure.
Most of the time, the only way to counteract the damage that particulate matter can do to your heart and brain is to move away from it — not always a practical solution. Now, scientists have found that omega-3 fish oils can fight damage caused by dirty air.
Read more: 6 ways to prevent air pollution from harming your heart
In a new study published in Environmental Health Perspectives, researchers from the Environmental Protection Agency and the National Institute for Environmental Health Scientists gave 29 healthy middle-aged adults either omega-3 fish oil supplements or a placebo of olive oil supplements. After four weeks of supplementation, the test subjects were placed in enclosed chambers for two hours while being exposed to pollution levels similar to those you might be exposed to in an average urban environment. Their blood was tested before and after the exposure.
After exposure to pollution, the people on fish oil supplements experienced much lower heart rate variability, a marker for cardiovascular damage, and other markers of cardiac distress, than the people taking olive oil supplements. At the same time, although both groups had similar LDL (bad) cholesterol and lipid (blood fat) levels before exposure, those levels spiked in the olive oil group but remained steady in the fish oil group.
The effects of air pollution on heart health have become so pervasive that an entire medical field, called environmental cardiology, has cropped up to treat them. And most environmental cardiologists previously believed that the best way to protect against the damages of air pollution was to ward off heart disease entirely, for instance, eating healthfully, eliminating cigarettes and exercising to reduce both weight and stress levels. This study shows that adding fish oil supplements to that list will help keep you from succumbing to air-pollution-induced heart problems.
Read more: Fish or fish oils for healthy heart?
The participants in this study took 3 grams of fish oil per day every day for four weeks, which is an average dose for most over-the-counter supplements. However, not all supplements are created equal, particularly with fish oil.
It's important to choose high-quality products to prevent exposure to contaminants such as mercury and PCBs:
• Consult independent tests. Although most fish oils used in supplements come from species that aren't high in mercury and PCBs, that doesn't mean a few poisoned poisson don't make it into the mix. The Environmental Defense Fund surveyed 75 fish oil manufacturers to see if they purify their fish oils to remove PCBs and mercury, and published a list of the healthier supplements. Alternately, consult the third-party supplement-testing service ConsumerLab.com, which conducts annual tests on fish oils and looks for contaminants that could undermine the health benefits of your fish oil supplements.
• Read labels wisely. Concentration of the different omega-3s in the fish oil can vary, according to tests from ConsumerLab. The most beneficial fatty acids are EPA and DHA. In this study, the effective dose contained 410 milligrams of EPA and 274 milligrams of DHA.
• Don't confuse price with quality. Just because a brand costs more doesn't mean you're getting a better-quality product. In ConsumerLab tests, some of the best-quality supplements with the lowest levels of contaminants cost just 6- to 10 cents per serving.
• Don't be duped by meaningless claims. "Pharmaceutical-grade," "contaminant-free" and "tested in FDA-approved laboratories" do not carry weight. The Food and Drug Administration (FDA) does not approve analytical labs, although some labs could be FDA registered and inspected.
Story by Emily Main. This article originally appeared on Rodale.com and is reprinted here with permission.


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Are You Worried About Spending Money?
Click on the link to watch the video for a one-minute inspirational blast!
Jason Freeman is a professional writer, and a one-of-a-kind public speaker. He is the founder and CEO of Heroic Yes! Productions. Jason has an MFA in Poetry from the University of Nebraska. He knows the pain of perceiving one's life through a lens of limitation and also the thrill of moving beyond that mindset. For more information on Jason's powerful message, or to book him to present to your organization, go to www.HeroicYesProductions.com.

subset: commoncrawl


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Name: Louie
Breed: German Warmblood
Discipline: Hunter/Jumper
Age: 15
Owner: Kaitlyn Granger
Louie has always had terrible feet. His hooves were soft and he lost shoes on a regular basis. I've tried a lot of hoof supplements and SmartHoof is by far the best and the most cost-effective formula I've found. My farrier and I have both been really pleased with the quality of his hooves since we started using SmartHoof. In fact, I love the entire SmartSupplements line because the formulas are economical and high quality.
Why Kaitlyn Uses SmartPaks
I love the SmartPaks system because I always know that Louie is getting the right amount of his supplements every time no matter who is feeding.
How Supplements Help Kaitlyn's Dog
Name: Ginger
Breed: Shiba Inu/Lab Mix
Age: 11
We decided to put our dog on SmartCanine Joint because we've had so much success with SmartPak supplements for the horses. Ginger seem to be much happier and is more willing to go on longer walks.


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|Stilbenoid, diarylheptanoid and gingerol biosynthesis - Reference pathway
|Stilbenoids are a group of phenolic compounds, biosynthetically interrelated through their common origin from a C6-C2-C6 intermediate, such as resveratol found in grapes. Stilbenoids can also exist as glycosides (e.g., piceid). Combretastatins are potentially useful stilbenoid natural products with known antitumor activity. Diarylheptanoid is a compound group having phenyl rings at 1,7 positions of n-heptane (C6-C7-C6), such as curcumin found in the ginger family. [6]-Gingerol is a major active component of ginger and has diverse pharmacologic effects.


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Federal autopsy ordered in Missouri teen's death
FERGUSON, Mo. >> Attorney General Eric Holder on Sunday ordered a federal medical examiner to perform another autopsy on a black Missouri teenager whose fatal shooting by a white police officer has spurred a week of rancorous and sometimes-violent protests in suburban St. Louis.
The "extraordinary circumstances" surrounding the death of 18-year-old Michael Brown and a request by Brown's family members prompted the order, Department of Justice spokesman Brian Fallon said in a statement.
"This independent examination will take place as soon as possible," Fallon said. "Even after it is complete, Justice Department officials still plan to take the state-performed autopsy into account in the course of their investigation."
As night fell Sunday in Ferguson, another peaceful protest quickly deteriorated after marchers pushed toward one end of a street. Police attempted to push them back by firing tear gas and shouting over a bullhorn that the protest was no longer peaceful.
The Justice Department already had deepened its civil rights investigation into the shooting. A day earlier, officials said 40 FBI agents were going door-to-door gathering information in the Ferguson neighborhood where Brown, who was unarmed, was shot to death Aug. 9 in the street.
A federally conducted autopsy "more closely focused on entry point of projectiles, defensive wounds and bruises" might help that investigation, said David Weinstein, a former federal prosecutor who supervised the criminal civil rights section of Miami's U.S. attorney's office. The move is "not that unusual," he added.
Federal authorities also want to calm any public fears that no action will be taken on the case, Weinstein said.
President Barack Obama, who has been getting regular updates on the situation in Ferguson while on vacation, was to be briefed by Holder sometime after returning Sunday to the White House.
Back in Ferguson, the latest clashes erupted three hours before the midnight curfew imposed by Gov. Jay Nixon.
Police in riot gear ordered all the protesters to disperse. Many of the marchers retreated, but a group of about 100 stood defiantly about two blocks away until getting hit by another volley of tear gas.
Protesters had laid a line of cinder blocks across the pavement near the QuikTrip convenience store that was burned down last week. It was an apparent attempt to block police vehicles, but the vehicles plowed through with ease. Someone set a nearby trash bin on fire, and gunshots rang out several blocks away.
Earlier in the day, Missouri State Highway Patrol Capt. Ron Johnson said he had met members of Brown's family and the experience "brought tears to my eyes and shame to my heart."
"When this is over," he told the crowd, "I'm going to go in my son's room. My black son, who wears his pants sagging, who wears his hat cocked to the side, got tattoos on his arms, but that's my baby."
Johnson added: "We all need to thank the Browns for Michael. Because Michael's going to make it better for our sons to be better black men."
The Rev. Al Sharpton told the rally Brown's death was a "defining moment for this country."
Sharpton said he wants Congress to stop programs that provide military-style weaponry to police departments. He said he expects police to "smear" the slain teenager, his family and his attorneys. He also condemned the recent violence and looting in Ferguson.
The protests have been going on since Brown's death heightened racial tensions between the predominantly black community and the mostly white Ferguson Police Department, leading to several run-ins between police and protesters and prompting Missouri's governor to put the state highway patrol in charge of security.
Ferguson police waited six days to publicly reveal the name of the officer and documents alleging Brown robbed a convenience store shortly before he was killed. Police Chief Thomas Jackson said the officer did not know Brown was a robbery suspect when he encountered him walking in the street with a friend.
Nixon said Sunday on ABC's "This Week" that he was not aware the police were going to release surveillance video from the store where Brown is alleged to have stolen a $49 box of cigars.
"It's appeared to cast aspersions on a young man that was gunned down in the street. It made emotions raw," Nixon said.
Police have said little about the encounter between Brown and the officer, except to say that it involved a scuffle in which the officer was injured and Brown was shot. Witnesses say the teenager had his hands in the air as the officer fired multiple rounds.
"When you're exhausted, when you're out of resources, when you're out of ammunition, you surrender," Brown's uncle, pastor Charles Ewing, told worshippers during a Sunday sermon at Jennings Mason Temple in Ferguson. "He surrendered and yet he died."
The officer who shot Brown has been identified as Darren Wilson, a six-year police veteran who had no previous complaints against him. Wilson has been on paid administrative leave since the shooting, and the department has refused to say anything about his whereabouts. Associated Press reporters have been unable to contact him at any addresses or phone numbers listed under that name in the St. Louis area.
Also Sunday, about 150 people gathered in St. Louis to show support for Wilson. The crowd protested outside a TV station because it had broadcast from in front of the officer's home.
The St. Louis Post-Dispatch said the station, KSDK, later apologized. Other in the group, composed mostly of police and relatives of officers, carried signs urging people to wait for all the facts.


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Guest Reviews
Overall Experience
The Staybridge Suites® Austin Arboretum hotel offers convenient access to Mopac and downtown Austin, as well as an appealing environment set apart from the city bustle. Our hotel serves as your home on the road with complimentary guest amenities that matter the most for business and leisure during short term and extended stay travel.
Business travelers find our hotel near IBM, Hewlett-Packard, Cisco and National Instruments, a satisfying choice among hotels. We offer free Wi-Fi and a 24-hr Business Center so you can stay connected to the office while being productive during travel. After work, meet and mingle with guests at The Social every Monday through Wednesday evening with complimentary drinks and light appetizers.
Visit downtown Austin during your stay and enjoy local favorites. The Arboretum and Domain shopping malls are perfect for grabbing souvenirs and the nearby Lake Travis offers a scenic getaway.
No matter the reason for your travel, you'll enjoy the home-like comfort at this hotel. With a free daily breakfast, free laundry facilities, suites with more space, a patio and an outdoor pool, guests are sure to have a better stay at Staybridge Suites Austin Arboretum.
Overall Experience
May 25, 2020
Some of your chain hotels are the worst., Auston Arboratem hotel is better.
May 22, 2020
Hospitality, excellent. Warmth at front desk, second to none. Cool Quiet Stay. Great job guys! Please know you're appreciated. Please keep it up!
May 18, 2020
The staff were super nice and willing to help with answers to any questions I had.
May 16, 2020
Amazing experience for the value and comfort. My go to spot on Austin now.


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Sunday, October 9, 2011
Voorhees Hall–There and Gone
I'm not sure of the exact date on the above postcard of Huron College (Huron, South Dakota), but would guess it to be ~1910. I grew up looking at this wonderful old building, Voorhees Hall, and during a few times in my childhood, had occasion to enter this grand structure, always captivated by the beautiful architecture. Eventually, I went to school there myself. Within those old walls you could almost feel the history, and going up to the huge lecture room on the third floor you could feel the presence of one hundred years' worth of scholars, filling their minds with worldly knowledge.
So this was a particularly sad time for me when a friend sent the photo below. Voorhees Hall is no more – razed to make way for a swimming pool.
It's going to take a very long time before seeing this sight doesn't hurt…
Photo courtesy of Michael Bonnes
4 comments:
Isn't it sad to see our childhood places of the heart disappear! I have some of those and had not thought of them for awhile. Guess we are lucky to have the memories and a few photos to hold dear. I have some of our depot that your post makes me think of--I may have to get busy and share those!ReplyDelete
BTW...I have not forgotten to check the mag, just have not had a work day at the museum lately but I will get to it!ReplyDelete
The same thing happened to my Grandmother's house on Richard and Ring Streets. The building was over a 100 years old. I know it was structurally sound as my father was a builder. It sold in the 1980's and shortly after the sale was torn down. To this day it still is a vacant lot.ReplyDelete
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Wedgwood Gifts For Baby
Discover the perfect gift to make their first memories special. These keepsakes from the Wedgwood range are the perfect choice to bring a special touch to any babies cherished moments. The range of gifts have stunning options for every occasion, whether it's a baby's baptism or christening, or to mark babies first gift. There is something for every occasion to help cherish early memories for the rest of their life.
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Consumer Services
The Georgia Department of Law's Consumer Protection Division protects Georgia consumers and the legitimate business community in a number of ways:
Investigating consumer complaints. Complaints filed with this office alleging fraud may form the basis for an investigation into a company's business practices. A significant quantity of complaints about a business may give rise to legal action—not on behalf of the individual complainants, but to enforce state law. The decision to investigate or file a lawsuit is based on a variety of factors.
Georgia Department of Law's Consumer Protection Division also serves as an information resource in the self-help Lemon Law complaint process and provides arbitration hearings for those eligible consumers whose motor vehicles have not been repaired by the manufacturer in a satisfactory manner.
Filing civil lawsuits on behalf of the State of Georgia and the public good, under the Georgia Fair Business Practices Act and other consumer protection statutes. While this office cannot represent individual consumers, some legal actions do produce restitution for individuals, as well as serving as a deterrent to other potential violators. Read about some of our recent successes.
Georgia Department of Law's Consumer Protection Division works to obtain reimbursement from businesses for consumer losses or obtain settlements concerning companies' future activity. We can issue hefty fines against those who violate consumer protection laws and seek greater penalties where the victims are elderly or disabled. Our office can order businesses to stop unfair or deceptive activities by issuing cease-and-desist orders. We can file legal action against companies or individuals operating in violation of Georgia law and seek injunctive relief, court-ordered civil penalties or other remedies.
Pursuing criminal charges against individuals or companies who commit fraud through identity theft, telemarketing, home repair, or a computer network such as the Internet. A few of the recent cases that resulted in criminal prosecution are spotlighted here.
Educating consumers — a vital part of our mission. We believe the best consumer protection is a widespread public awareness of consumers' rights and of the most common snares in the marketplace. This knowledge helps people deal more effectively with businesses and make better choices and decisions. On this web site we are pleased to inform the reader about many different consumer issues, including alerts to new or urgent information.


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I also sent SiriusXM Music Dept. two e-mails. The first reply was their normal form reply where they didn't even mention what I was talking about really. I got a little more out of the second one, here it is.
We appreciate the time you have taken to contact us regarding Leo G.,
former Director of Programming for Hip Hop Nation. We are here to
assist you!
Sean, we understand your concern that we misinterpret you first email.
Sounds like Leo G. has a large following. We are not aware of any of
the particulars with what took place regarding the cutting of Leo G. but
will assure you we are forwarding your email to the appropriate
We are committed to providing you with the best in customer care. If
you have any more questions, please feel free to contact SIRIUS Customer
Care. For your convenience, we are available 7 days a week at:
SIRIUS Customer Care: 1-888-539-7474


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Jane Stevenson and Mark Daniell talk about Taylor Swift's latest album and wonder if she can surpass Adele for record sales.
Top Stories
This Week's Flyers
We encourage all readers to share their views on our articles and blog posts. We are committed to maintaining a lively but civil forum for discussion, so we ask you to avoid personal attacks, and please keep your comments relevant and respectful. If you encounter a comment that is abusive, click the "X" in the upper right corner of the comment box to report spam or abuse. We are using Facebook commenting. Visit our FAQ page for more information.


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School of Education Relocations
CTS has been instrumental in relocating the School of Education to prepare for construction that will take place in Park Hall. Approximately thirty faculty and staff computers were moved along with their associated printers and other peripherals for the School of Education Dean's Office, VTP, Tech Ed, Ed Admin, and Field Placement offices. Phones were also moved and approximately 75 machines for computer labs were moved. Not only were physical devices relocated, but network connections in their new locations for both phone and computer were configured. The School of Education Dean's Office was moved from Wilber to 201 Culkin. VTP and Ed Admin were moved from Park Hall to Hewitt Union. Tech Ed was moved from the first floor of Wilber to 356 Wilber. The Field Placement Office was moved from Park to 252 Wilber.


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Would you like to go live on Mars?
A Dutch company called Mars One has announced plans to create the first human settlement on the Red Planet in just 10 years.
Mars One plans to pick travelers to submit to a full-time training program that will conclude with a one-way ticket to Mars, where a prepared colony will be waiting.
Prospective colonists must be at least 18 years old, and the Mars One team says qualities such as resiliency, adaptability, creativity, resourcefulness and curiosity will be given high priority. All necessary skills for Mars survival will be taught to the colonists over the next decade as they prepare full-time to blast into space--and history.
Mars One founders Bas Landsorp and Arno Wielders, entrepreneurs with ties to technology and space industries, said they plan to send probes and rovers as early as 2016 to prepare the planet for human habitation.
And--no surprise here--they plan to fund the mission through the wonders of Reality television.
According to the Los Angeles Times, Space X founder Elon Musk is also eyeing plans to populate Mars, offering aspiring Martians berth for the low low price of half a million dollars.


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Wander the Web Wednesday
First of all, I don't like doing the double or triple post a day thing, but I have a whole list of topics to get to and not enough time or days in the week to do it. Plus, I like doing the Wander the Web Wednesday meme. So, Wednesdays will be the two-for-the-price-of-one day. Enjoy this and I'll have another entry up later today. Oh and don't forget the new season of Ghost Hunters premieres tonight.
The idea is to highlight 5 links that you feel would be new to other readers.
They can be daily reads, or personal favorites.
They may even just be something fun or freaky or just plain fascinating that you stumbled into recently.
If you want to "play along" make a list on your site and link to it in 2 Witches Blog comments. They'd also appreciate a link back.
1. WasArrested.com - Just a fun site where you can write a fake news story.
2. Paranormal Awareness Society Network - haven't had time to fully explore this site yet, but you might want to.
4. Bigfoot Quest - I think the name pretty much says what the blog is mostly about.
5. Paranormala - Has a little of everything, paranormal and then some.


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Midway through the second quarter of yesterday's Titans-Colts game, Tennessee intercepted an Andrew Luck pass and returned it for a touchdown. While Indianapolis would get two late field goals to secure a 27-23 win, without them the margin of victory would have hinged on this play—and as you can see above, Luck's clearly down by contact.
Since the play featured both a turnover and a score, it was automatically challenged by the replay official; despite the evidence you see above, the call on the field was upheld and the Titans awarded the score. Why? The CBS broadcast suggested the replay that shows Luck was down wasn't made available to the replay official. That's curious, because replay officials are supposed to have unhindered access to the full video system and all its available replays. It's not clear why this one showed up later, after the fact, but if you have any details let us know below.
Got any stories or photos for us? Tip your editors.


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Question: What do Marilyn Monroe, Abraham Lincoln, Tipper Gore, Jackson Pollock, and Edgar Allen Poe all have in common?
Answer: All have dealt or currently deal with depression in their lives.
Depression is a serious medical condition. Contrary to popular belief, depression is not something that you can "snap out of" or something that is "just in your head." Signs and symptoms of depression include a persistent sad or anxious mood, feelings of hopelessness and pessimism, feelings of guilt, helplessness, or worthlessness, and a loss of interest or pleasure in hobbies and/or activities that were once enjoyed (NIMH, 2006). Other symptoms may include decreased energy and fatigue, difficulty remembering, a change in appetite (including significant weight gain or weight loss), difficulty concentrating, insomnia or oversleeping, thoughts of suicide, irritability, headaches, and chronic pain.
Depressive illnesses are not moments of sadness or blue periods; rather depression is a condition where a feeling of sadness and unhappiness can last months and even years. Depression can affect appetite or sleep and affect your mood and thoughts (NIMH, 2006).
Depression is quite common and nothing to be ashamed about. In fact, in a given year 20.9 million adults suffer from a depressive illness. The sad truth is that few of the 20.9 million people affected by depression seek treatment. Even the most severe depression can be treated. Depression is not a sign of weakness and may not be able to be overcome simply by trying to "pull it together" (NIMH, 2006)
Depression can be hereditary, but it can also occur in families who have no prior history of depression. Women are twice as likely to have depression as men and they are prone to depression after they give birth to a baby. Brooke Shields revealed in the media that she struggled with post partum depression and helped get the word out that depression can happen to anyone (NIMH, 2006). Depression can also be triggered by situational stressors.
If you suspect you might be depressed or if anyone you know is struggling with depression, please feel free to visit the UIS Counseling Center, located in HRB 64 or call the center at: (217) 206-7122
By: Stefanie Rennecker and Vince Flammini.


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Monastic WalesThe religious houses of medieval Wales have long been overshadowed by their more numerous, generally more prosperous, and normally better documented neighbours east of Offa's Dyke. Yet their history is inseparable from the religious, cultural, economic, political, literary and urban history of Wales during the period between the arrival of the Normans in the late eleventh century and the Dissolution of the Monasteries in the sixteenth.
The Monastic Wales projectIn an attempt to identify more firmly Wales's place on the monastic map of Europe, this new large-scale project seeks to establish a comprehensive monastic history of medieval Wales, the findings of which will be made available to scholars and students, as well as the wider public, both electronically and in print. Initially this comprised monasteries and houses of canons which were active in Wales for some or all of the period from the late eleventh century until the Suppression of the religious houses in the sixteenth century. At present the database is being extended to include the friars.
The first phase of the project was the creation of a database and website which can be used as both a research and a teaching tool. This will be regularly updated and expanded; the interactive element in the design enables external participation. The website was officially launched in October 2009. It will eventually comprise a full bibliography of primary sources and secondary literature, links to relevant web-published material and research tools, and reports on related work in progress.
The Project seeks also to encourage new research into aspects of Welsh monastic history and to provide a platform for unpublished material and new work. Essays and articles will be available to users on the website. A comprehensive history of monastic Wales, with contributions from leading scholars in the field, will be published in book form.
The main database currently contains:
© All material on this website is copyright Monastic Wales unless otherwise noted.


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by Peter B. O'Connor
Two months ago my five-year old son Jack and I decided we would adopt a cat. We both love animals, and our dog Alice would hopefully enjoy the company. I told him that anyone could get a kitten, so why not get something special, something that nobody else would want. We looked on Craigslist and found a one-eyed cat that needed a home. He was about eight years old, and we were told that he was loving and gets along fine with dogs.
We went to the Mt. Airy home where he was being fostered by a wonderful girl named Katie Locke. When Jack and I met the one-eyed cat, we both thought, "Yes; he would be a perfect addition to our home. I wanted to name the cat 'Argh,' but Jack quickly said, 'No; lets call him Happy Pirate.'" "So Happy Pirate it is," I said. We needed to wait a week as Happy Pirate had an ear infection that needed to heal before he could come home with us. In the meantime we got all the things you need for a cat: litter box, kitty litter, food, toys, etc.
The day before Happy Pirate was to come home, Katie called me in tears, saying that she had to take Happy Pirate to Penn Veterinary Hospital the night before because he was not well. He did not respond to any treatments and was suffering so they had to do the humane thing and put him down. Happy Pirate was dead. I explained to Jack that Happy Pirate got sick and died but was now in heaven with both of his eyes.
Katie felt horrible as she knew Jack and I had our hearts set on this little cat. She asked me if there was anything she could do for us. I told her if she ever gets a "freak" cat, someone that nobody else would want, a cat that's deaf or blind or with three legs, to please call us.
She said with tears in her voice, "Really? I have a three-legged cat sitting on my lap right now." She was found wandering around West Philadelphia with a mangled leg, and it was just amputated a couple of weeks prior.
So a few days later she brought the kitten to visit us. It was love at first sight. She is small, very affectionate and hops around like a little rabbit. When Alice the dog met her, they each sniffed each other, and Alice sort of looked at me with a "What the heck is she doing in my house?" look. After the visit Katie told us we needed to wait a week until the stitches were removed and she was given a clean bill of health before she could come to our house for good.
I wanted to stick with the pirate theme and name her Peg. I mentioned this to Jack, and he said, "Let's name her Pegasus after the flying horse." So Pegasus it is. She came to us the following week and has settled in quite nicely. Alice the dog is getting used to her, and Jack loves that she sleeps under the covers with him. She does eat like a pig, and I caught her once after she stole a whole breakfast sausage off of Jack's plate. I let her keep it.
As for all the silly toys we bought her, she prefers rolled up pieces of newspaper or tissues or the dogs tail. Note to self: Don't buy anything except food for the cat.
If anyone is thinking about adopting a cat, I suggest getting in touch with Animal Care and Control Team Of Philadelphia at wwwacctphilly.org (Ed.note: Or contact our area's Saint Rescue, otherwise known as Brenda Malinics, at 215-872-1636 or email@example.com)
Peter and Jack O'Connor live in Chestnut Hill. For more information, email:firstname.lastname@example.com


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Mothers in Upper Egypt say "No to Female Genital Mutilation"
March marks the celebration of Egyptian Mother's Day and the International Women's Day. This year, in the governorate of Aswan, we have also honored 100 mothers and families that have abandoned the practice of FGM and become powerful advocates against this harmful practice that goes against the basic human rights of girls and women. In so doing, they have also ensured the continuation of their daughters' education and prevented child marriage.
The FGM Abandonment and Family Empowerment Programme is showing the results of efforts that started 10 years ago with the FGM Free Village programme sponsored by UNDP. The first milestone was achieved in 2008 when the Parliament passed a law criminalizing FGM. Aswan was the first governorate to announce an anti-FGM stance in 2004 (Benban village). In March 2014, the general prosecutor has referred the case of Soheir El-Batea, a 13-year old girl who died as a result of a FGM operation, to criminal prosecution.
- The FGM Abandonment and Family Empowerment Programme is showing the results of efforts that started 10 years ago with the FGM Free Village programme sponsored by UNDP.
- . Aswan was the first governorate to announce an anti-FGM stance in 2004 (Benban village).
Among the mothers honored in Aswan, the story of 43 year old Samia Helmy from Nagei el Arab Village is the most touching. It reflects women's persistence in Upper Egypt despite the suppressive socio-cultural conditions they live in, especially in rural communities.
Samia is a victim of third degree mutilation (so-called Sudanese circumcision, most severe form). As a result, she has faced painful health problems ever since, significantly affecting her living conditions and marital life. She recognizes that while she always tried to maintain intimate relations with her husband, these mostly failed as they entailed pain and fear. Despite this, Samia and her husband have a 15 year old daughter. When the FGM Abandonment Programme started working in Aswan in 2004 her daughter was just 5 years old.
Samia became one of the first women who attended the programme's awareness classes to try understanding her own case and problems. She made a clear relation between the tragic day of her circumcision and all the symptoms and desperation she sees in her life as a woman and ill-fated marital relations with her husband whom she sees as "a good and kind man". She started speaking with other women of her age and with her husband about her daughter and whether they should circumcise her or not.
She faced fierce opposition from her in-laws requiring her to comply with tradition ("this is our culture and you are the only woman that has a problem with it"). Her mother in law constantly belittled her by blaming her for being a "cold wife with no feelings or passion". Nevertheless, Samia persisted. She had long talks with her husband about sparing their daughter all the pain she went through. He was eventually convinced to join the awareness sessions held for men. As they became better informed, they decided to stand up as a family and face those community members staunchly defending tradition.
Mihrael Malak is now 15 years and her parents are proud to see her growing up healthily, attending school and dreaming about a future of her own. Samia is a lead advocate in her village using her personal testimony to put an end to this abject practice that prevents women's' development as human beings and impacts on the healthy development of communities as a whole.
The FGM Abandonment and Family Empowerment Programme is a joint partnership among the National Population Council, UNDP, UNICEF, UNFPA, UN Women, local authorities, civil society organizations, and is implemented thanks to the generous contributions of the European Union, and the Governments of Sweden, The Netherlands and Germany.


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PROVIDENCE, R.I. (AP) — Sean McGonagill hit back-to-back 3-pointers with less than five minutes remaining to help Brown pull away and defeat Pennsylvania 62-55 on Saturday night.
Penn led 51-47 with 4:45 left before McGonagill's two treys sparked a 15-4 run to give the Bears the win. Steven Spieth scored six of his 12 points during the span.
Cedric Kuakumensah had 18 points, 10 rebounds and two blocks to lead Brown (13-9, 5-3 Ivy League), which is two games back of Yale for the top spot in the standings. McGonagill finished with 15 points, including four 3-pointers, and is now just five treys shy of becoming Brown's all-time career 3-point leader.
Darien Nelson-Henry scored 20 points on 9-of-20 shooting to lead Penn (6-15, 3-4), which has lost two straight. Tony Hicks added 16 points with five assists.


text:
Missing millionaire's wife and mother battling over fortune
We've heard from the mother of manic-depressive millionaire Guma Aguiar. Ellen Aguiar said she believes her son, who went out on rough seas Tuesday night and didn't return with the boat, is dead.
"The likelihood is that he was tossed off the boat into the waves," she told ABC News.com. "The boat was found, but the body has not been found."
Now we hear from Aguiar's wife, Jamie, who released this statement exclusively to Local 10 in reaction to her mother-in-law's words. She remains hopeful even though the Coast Guard search for Guma was reportedly called off last night. "I am deeply devastated by the disappearance of my husband and my children's father. We are in continuous contact with the Coast Guard and the Police Department, and are cooperating fully in the effort to help find Guma. ... Above all, we remain hopeful that Guma will be returned home to the family that misses him dearly."
Make no mistake: This is a family that has long been feuding over a Aguiar's fortune and his mysterious disappearance has only intensified that fight.
When Aguiar's empty boat came ashore in Fort Lauderdale early Wednesday morning, the missing man's pants, wallet, and cell phone were found by police. Ellen Aguiar contacted police and obtained the cell phone and wallet. When Jamie Aguiar learned of this, she demanded that police get the items back from her mother-in-law, said Bill Scherer, one of the wife's attorneys.
Yesterday, Ellen Aguiar filed a petition at the Broward County Courthouse to take over her son's fortune, which is valued at about $100 million (and was over $200 million not long ago). Scherer said Jamie Aguiar is going to fight against that happening.
In the background is Aguiar's uncle and former business partner, billionaire Thomas Kaplan, who has been locked in a high-stakes legal battle with Aguiar over the $200 million Aguiar received as his share of a natural gas drilling company the two men built. Kaplan is Ellen Aguiar's now estranged brother.
Stay tuned on this one because there's much more to report.
-- There was no crying on this trophy. After one of the greatest seasons ever played, LeBron James' laughed instead with pure joy. He's still young, the other emotions will probably hit him later.
Then again there wasn't much emotion in the final game. Miami had OKC's heart in its hand -- and it squashed it. What a player, and in the end, what a team. James carried this team the entire season with an iron resolve, but everyone was involved in this championship. Wade's greatness came through when it was needed most, with a highlight pass, block, whatever it took. And they couldn't have done this without Chris Bosh. His shooting, his rebounding, and his length were life savers. That's why it's the Big 3.
And the role players? By the end they were having their own personal three-point shooting contest. Mike Miller played last night like a man who really really wanted to sell his house. It was great to see after a tough year he's had with a back that's so bad you can feel the pain through the television when he struggles down the court.
Miller was following the lead set by Shane Battier, early in the series, and Mario Chalmers late (sparked by Norris Cole's Game 4 exploits). And Pat Riley, who put the team together, was like a guy freed from jail. Nobody wears winning better than Pat Riley, or losing much worse."Can we have Can we have a party tonight?" he asked, rousing up the crowd. "Is it okay to have a party tonight?"
I think this one may go into the weekend.
Copyright 2012 by Post Newsweek. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


text:
Wade Olson Interviewed About KDE 4
Gartner Webdev has published an interview with KDE's very own marketing renegade Wade Olson. Wade talks about KDE 4, what makes it special and what KDE's role in the software market is. He sheds some light on the user's point of view and discusses his vision about the way the computer and software industry is moving. Read the interview for yourself.
Nice interview, Wade ;-)
By Jos Poortvliet at Wed, 2007/08/29 - 5:00am
Definitely nice!
Definitely nice! Though I found the questions a bit standard, but the answers give a nice positive image for Open Source software. It's a blessing to read something like this instead of the next OOXML scandal, and I hope more people will pick this news up. I like reading good news too :)
By Diederik van de... at Wed, 2007/08/29 - 5:00am
Re: Definitely nice!
I really like the answers, great interview!
>> instead of the next OOXML scandal
Oh, you're Swedish too? Or have I missed something important? (Wouldn't be surprised if I have; haven't had access to the net for some weeks :/)
By Hans Chen at Thu, 2007/08/30 - 5:00am
Re: Definitely nice!
Seems to me more that the discussion about the ISO scam lacks audience.
By bert at Fri, 2007/08/31 - 5:00am
mainstream-ish sources
Very good blog!! Let's hope the " mainstream-ish sources" will pick that one up too!
By cossidhon at Thu, 2007/08/30 - 5:00am
Re: mainstream-ish sources
I was actually referring to Aaron's blog "On the success of KDE4", but I hope both stories get picked up.
By cossidhon at Thu, 2007/08/30 - 5:00am
Re: mainstream-ish sources
Nah, they all love GNOME these days, sadly, with them telling everybody to use Ubuntu (when they should be promoting *K*ubuntu or another KDE-based distro instead)
By Amy Rose at Tue, 2007/09/04 - 5:00am
In other news...
Flames are raising and raising for KDE 4.0, and I have to agree with the part that there was too much hype for KDE4. Man I hate those fancy sites for new KDE technologies as Plasma and Phonon, it's pure hype.
But in the end, I think the discussion is healty and will lead to better releases or better communication between developers and users.
By Iuri Fiedoruk at Thu, 2007/08/30 - 5:00am
Re: In other news...
Having read part (about half) of that discussion, I do not find it to be overly flaming. There is quite a good balance in fact.
I find it amusing to see how KDE 4.0 will probably have all the nice, cool base technolgies in place, but not yet the applications to use them (not so bad, that will happen in time), while in the Vista release most of the cooler technologies got dropped and all[1] that's left is a shiny new UI. I think I know what I prefer...
[1] OK, ok, that is not all of course, but you get my point.
By Andre at Thu, 2007/08/30 - 5:00am
Re: In other news...
Yep, it's not as bad as I expected. Partly because some KDE guys jumped in probably (superstoned.... :-)).
Anyway, there are comment I've also seen elsewhere about how "more gradual development is better than those big shake-ups".
By Richard Van Den Boom at Fri, 2007/08/31 - 5:00am
Re: In other news...
Really, how do you think the millions of lines of KDE4 do get written? The largest part is using stuff from KDE3, of course!
If you have 1 Million lines, and one developer can write like 10k lines per month at absolute maximum. Consider, where you will take the 1,2 Million lines that your project needs.
I think only the linux kernel is a fine exception to this, with 20MB patches per month, significant parts get replaced.
Design changes are necessary, but for the largest part, code is to be reused in big parts. When Plasma replaces kicker and kdesktop, it's mostly new stuff... but in kwin on the contrary, old code prevails. And most of the old things are not deeply rewritten, only optimized.
By Debian User at Fri, 2007/08/31 - 5:00am
Re: In other news...
Yes, you're right, of course.
By Richard Van Den Boom at Sat, 2007/09/01 - 5:00am
Re: In other news...
I think the only real hype i saw as instigated by the plasma revolution.
It cooled off now a lot, the practical view has settled in.
What I will test a lot is the scripting support and widget usabilty - for ruby :)
This will be my personal pet peeve against gnome, because I know for sure
By she at Thu, 2007/08/30 - 5:00am
Re: In other news...
Not to detract from your choice of desktop and development environment, GTK/Gnome has Ruby bindings as well:
Good luck programming Ruby, no matter which set of libraries you choose.
By phoebus at Thu, 2007/08/30 - 5:00am
Re: In other news...
> I think the only real hype i saw as instigated by the plasma revolution.
can you expand on this? you leave out who you are referring to in each of these sentences, what the "hype" and "practical view" are/were and what the consequences of each are.
perhaps unsurprisingly, i happen to care about these things and so would like to hear what you are thinking in greater detail.
By Aaron J. Seigo at Thu, 2007/08/30 - 5:00am
Re: In other news...
Maybe I can elaborate on this a tiny bit.
From my point of view, there was at the start of KDE4 cycle a massive amount of blogs from you, the now KDE president, then active voice. A website was created as the first action.
You have defended with great vigor and enthusiam the idea that Plasma would be innovation. Even when at the time, this was understood as SuperKaramba merging into kdelibs only. Some said it was not innovation, but you insisted.
I understand, you needed to pickup people to make sure, the common vision of what Plasma would be, could actually form. In my memory, it was also the first to have this kind of physical name, Solid, Phonon, etc. were to be follow up, which was a genius move alone.
You were about the only one visible at the time and it was obvious that you cared. Then you got hired to work on KDE and Plasma seemed to drop in priority, to the point, that people started to question if there was anything to be done, and seriously considered that it would not make it into 4.0.0, which was considered a grave problem for the very same reasons you gave initially on why Plasma was to be had.
What a lot people didn't see, was the massive amount of refactoring, cleanup and rearchitecturing that you personally did before working on Plasma. There was a total cool down and complete silence from you, not even mentioning Plasma over months, while being far from a no-blogger. I personally was frustrated a lot that you did this, while not disputing your right to it, or maybe I did. I will apologize for that.
Now Plasma exists and I give all the credit you deserve as part of making it come true. You made sure a group gathered to redo the visual appearance of KDE, you made sure the vision was built and finally, you also did a lot of code, to follow through on a great design. I really personally love the data source, data sink approach a whole lot, and it shows great potential, and growing use every day.
From my view, Plasma went all different than the other new KDE techs, for which small groups/individuals created complete plans and/or code first. Seems like a necessity, because Plasma is much harder to describe in words than the other things.
By Debian User at Sat, 2007/09/01 - 5:00am
Re: In other news...
thanks for the explanation. greatly appreciated.
> A website was created as the first action
more accurately, it was the first action you saw. it was not even close to the first action i took =)
> Then you got hired to work on KDE and Plasma seemed to drop in priority
a lot of people put a huge emphasis on me getting hired. it really changed almost nothing except my time availability. trying to draw conclusions between me getting paid and any of my actions since is going to result in wrong conclusions time and again simply because there aren't connections between my motivations or my chosen actions and that position. it simply allows me to more fully commit to what is going on.
> was a total cool down and complete silence from you,
i reached a point where i was personally sick in my heart with dealing with people who could not and would not be able to see the larger picture of things and refused to leave it alone. i had no means for cathartic release, so i withdrew large parts of my thoughts and communication from the outside. i wasn't happy about it then, and am little more satisfied with it i now.
it negatively impacted my motivation and my productivity. the result is that i will probably hold a fairly significant sense of negativity towards the general community of free software user enthusiasts for a while because of that period of time.
i don't expect unearned support or adoration, but i do expect a community where people are actually community members and supporters rather than consumer oriented feeders without a sense of empathy.
what i did in the early days of kde4 thinking and development was what i felt was necessary to get things on track and moving. along with many others, who are the true heros of kde, i put a huge amount of personal energy in to these things. i also put myself in the line of fire by being visible, outspoken and someone who was willing to stand as a representation of the responsibility those in the project quietly hold and live by.
i think it was all worth it, and would do it all over again. i'm personally quite ok with how things are unrolling. but i continue to pay for taking the early steps i did. how fun is that?
i'll continue to be miffed at people who proceed to rain on me and those i care about. as a means to deal with it, i've started thinking of such people as "customers" and not "my users" or "my community members" because that offers me the emotional distance i need from the sort of behaviour that many are evidently quite committed to engaging in.
this is all a very long winded way of saying: the community can either have a bunch of paid lackeys who probably don't truly give a rat's ass about you or you needs .. or you can play your part in creating a community. too many people seem to have forgotten that community isn't a gift you receive but a state of being you create with others.
> You were about the only one visible at the time
i'm glad that's changed, and i'm highly supportive of that change. it's the best thing for the project and its longevity. it's something several of us in the project have worked consciously towards making happen. i urge people who associate personal interest with the kde project to be nicer to those who have become visible and who will be more visible in the future. it's really in everyone's best interests to do so.
> and it was obvious that you cared
fwiw, i still do and don't yet see that changing one bit =)
Re: In other news...
By bert at Sat, 2007/09/01 - 5:00am
Re: In other news...
Hello Aaron,
on LKML there recently was a guy who proposed a new thinking in file systems, with some ideas. All he got was critics. I think LWN had a link to the guy who explained it, why that is so. In short, it's the best thing of all to learn what's wrong with something early on.
It's sad though when all the critics one gets is on the value level. Like this is not something to be excited about. Like don't do this, because do that instead. Like despair, others got better than even your plan.
Drawing fire is not fun. I remember you did it with "Usability" too. That was an even more important discussion to be had, and so successful. Your drawing and standing the fire, allowed that the insight can build up, and people who would never have stood the hate, to join the course and establish it within the community as a normal thing.
Considering that you are outspoken and will continue to be, may I point out, that it's _calling_ for fire to express your visions through existing means, that have lots of shortcomings. I remember seeing you mention "Nautilus" back then in Plasma discussion. It's not forbidden, it just means many angry replies without merit, this will reduce your communication ratio. I am a 100% sure, you either didn't understand that or like fire. The later of which is under doubt now. ;-)
One thing there is in the KDE user community: Part of it, that turned to KDE during KDE3 cycle, is absolutely scared of developers, coming from the Gnome of the time. Communication with that part of the community has been tough in both discussions, Usability and Plasma. There's not enough trust in that part of the community yet, there likely will only be by the time we see a 4.1 release.
All I can say is, I sincerely hope you have fun when you look back at how things turned out and when you code. Were I you, having helped push Usability into acceptance, would make me so proud.
And that customers thing: The other day, I saw many guys on a linux news site, complain in the context of a Gnome beta, that betas and release candidates were announced. That's customers, they only want ready for consumption.
By Debian User at Sun, 2007/09/02 - 5:00am
Re: In other news...
The definition of a successful free/open-source project is that is must have
For the entire lifetime of Plasma, it had all of those. (you mentioned superkaramba already).
The difference with Plasma was not so much the code or community; it was that Aaron used the ideas and concepts that big commercial projects use to create a community. And he thus reached a lot of people that don't know what a community is, they just know the concept of software producer v.s. software consumer.
I see this problem getting bigger as KDE gets more mainstream. A lot of ideas, schedules and deadlines which are clearly community based, and thus are calls to action for everyone. But they are seen by the people outside of the communities (os-news anyone?) as promises.
Short of them learning our ways; anyone an idea on how to bridge this gap better?
On a side-note; I regularly see questions from the PR people we have in KDE about a promise for something in a next release, or a date for a release. Those people actually do understand open source, but they feel that the users need promises, even though we can't make them. Which IMO is sad, really.
By Thomas Zander at Sun, 2007/09/02 - 5:00am
Re: In other news...
I just realised that all of the stuff in "the vision" of the Plasma page is pretty much put in place. When I first read the vision, I thought "well, it's just adding some more features and polish to the current desktop", then when I read some more of the concepts I was getting hyped. And now, everything seems to be just about ready:
1. Ability for the same applets can be both in desktop and panels.
Just about everything promised is there, or will be shortly. Now, we just need more applets and engines, which should happen as more people switch to KDE4.
By Soap at Fri, 2007/08/31 - 5:00am
Re: In other news...
please define what you mean by "pure hype".
By Aaron J. Seigo at Thu, 2007/08/30 - 5:00am
Re: In other news...
From front page:
I (emphasys on my person please, let's not start a flame war) don't see KDE4 desktop being different than enything else already in the market.
My understanding for the text (and forgive me, I'm not a natural born english speaker) is that Plasma is about reviewing the office paradigm of the desktop (for those who don't had Human Interface classes, the computer UI resembles a office with desks, metal containg cases for files, trashcan, and list goes on).
But, I have to agree with the first comment after mine in one thing: reading the text now that I know better what Plasma is becoming (Dashboard for KDE), makes much more sense, and is very less hype than the first time I read it.
At least here in Brazil those kind of sites, it's more used for limited-time campaingns for new released products or products that have a short life period. And in this case, you describe the product as something as revolutionary, give little information on what is or how it will be and build a huge hype around it.
By Iuri Fiedoruk at Fri, 2007/08/31 - 5:00am
Re: In other news...
I think two things are important to note here:
> I don't see KDE4 desktop being different
Define "The desktop". Some believe that's everything you see and thought Plasma would replace the window/menu/toolbar/widgets paradigm. I was a bit confused first too. Cute, but perhaps a bit overestimated. The desktop = kdesktop + kicker today.
However, with KDM and Amarok using libplasma, Plasma actually starts to get more impact then expected. The fact I can drag an photo or contact vcard to the desktop and see something different then an icon is something we haven't seen before. The fact it can be dragged from Amarok or to the taskbar is even more amazing.
> now that I know better what Plasma is becoming (Dashboard for KDE)
You're forgetting the form-factors, desktop zoom, extenders and data source / engine designs here. The whole picture is a lot bigger then "widgets". If you wanted just that, superkaramba would be sort-of good enough.
With plasma it becomes amazingly simple to rebuild your desktop with different start menu, taskbar and systray components. It's basically a do-it-yourself desktop. All the power and potential is there, so I do believe the _desktop_ will eventually change because of it.
By Diederik van de... at Fri, 2007/08/31 - 5:00am
Re: In other news...
See the link I posted under A. Seigo comment.
I agree in almost everthing you said, exept that Plasma still looks to me as Dashboard, and I belive, the features you talks about are present in MacOSX. You know, the taskbar on Mac is more than a taskbar and can do different things. I'm not a Mac user myself, but most things you talk about seems to me that already exists in a way or another, and most of them in Dashboard/Mac, just not in *nix/KDE.
But I will love to be proven wrong :)
By Iuri Fiedoruk at Fri, 2007/08/31 - 5:00am
Re: In other news...
some of the things do exist in other systems, including mac os. many do not. Diederik listed a few, and over time i'm sure you'll get acquainted with some of them first hand =)
i'm not going to list them and try and convince you. in return, perhaps you could lay down scepticism and claims of "hype" until i and the other plasma developers have a chance to deliver on what we are working towards.
4.0 is going to have the germ of the project and you'll see it unfold into being release by release. if you really want to track things closely, we'll be doing frequent and regular releases of plasma outside of main kde releases as a means to support the growth of a testing group.
Re: In other news...
PS: loved http://aseigo.blogspot.com/2007/08/on-success-of-kde4.html
Could not have said it better, and what I mean by disliking Plasma site is exactaly that it passes the idea that it is meant to be a revolution :)
Maybe now it's more clean what I was trying to say? (I hope so).
If KDE4 can lead to a revolution os a complete different story :)
By Iuri Fiedoruk at Fri, 2007/08/31 - 5:00am
Re: In other news...
> "KDE4 isn't a revlolution"
to help those that won't read that blog entry, the above is a misquote. the correct quote is: "4.0 won't be a revolution".
> it passes the idea that it is meant to be a revolution
it passes that idea because it *is* meant to be a revolution. the part you seem to be not grasping is that getting to "revolution" takes a whole lot of steps in between. that's how revolutions happen. you're getting to see those steps in between, something you don't usually get the privilege of, and because of that you're claiming "no revolution". what malarky.
see, plasma is not going to be released with 4.0 and then never touched again. plasma is not something that is a one stop affair with a release this year and then "whoop, that's it!". the design of it goes far beyond that first release. it is not "done" with 4.0. it is begun with 4.0.
you're trying to treat it as a end-of-life product when it's a living document. and yeah, that begins to piss me off.
> If KDE4 can lead to a revolution os a complete different story
at least that part is getting clearer for people. thank $DEITY.
Re: In other news...
One common mistake is that KDE4 and KDE4.0 are two quite different things.
KDE4 is the platform that will live for 5 years.
Its like the first 'version' of a sewer system being 4.0, they just put pipes in the ground but a lot of houses still had no way to use it so it went through the streets anyway. Not much of a revolution.
Hope that makes it more clear :)
By Thomas Zander at Sun, 2007/09/02 - 5:00am
Good News
KDE 4.0.0 is delayied in 2 months:
Now all this complains seems to had some reasoning, but the developers made the right move.
By Iuri Fiedoruk at Fri, 2007/08/31 - 5:00am
Re: Good News
Application Feature Freeze, except exemptions, is still in effect even with the delay.
By Luca Beltrame at Fri, 2007/08/31 - 5:00am
Re: Good News
So the reason some pieces where dropped is basically that they can't work without changing kdelibs API?
By Iuri Fiedoruk at Sat, 2007/09/01 - 5:00am
Re: Good News
No, simply because they require too much work to be put in, and rather than handing down something rushed and partially non functioning, they decided to postpone it so that there will be enough time to finish.
AFAIK, kwebdev is also not shipping for KDE 4.0 for the same reason (can someone from the project confirm that?).
And while I'm at it, I'm going to write why (IMO) statements like "wait till everything's ready" are not totally sensible at the moment. Basically, KDE 4.0 is part of the huge change that KDE4 will be. However, a key factor in a success of a DE is availability of applications, not necessarily tied with the DE itself. THe problem with an excessive (i.e. unplanned, don't misunderstand, I fully agree with the Release Team's decision to push the release to December) delay is that no 3rd party will start developing for the KDE 4 platform. Therefore I think it is important to bring KDE 4.0 out (not *rushing it*, of course) in order to make application developers aware of its existence.
By Luca Beltrame at Sat, 2007/09/01 - 5:00am
Re: Good News
Whoops, I meant "kdewebdev". Sorry.
By Luca Beltrame at Sat, 2007/09/01 - 5:00am
Re: Good News
"Dropped" is the wrong word. It indicates that we no longer have that feature which is incorrect.
As we say; there always is life after the next release!
By Thomas Zander at Sun, 2007/09/02 - 5:00am
Re: Good News
That's probably enough to make kde 4.0 suitable for production,
Also this means that in the consequent 4.1 develop there will really be
By nae at Sat, 2007/09/01 - 5:00am
Re: Good News
That's probably enough to make kde 4.0 suitable for production,
Also this means that in the consequent 4.1 develop there will really be
By nae at Sat, 2007/09/01 - 5:00am
Re: Good News
> KDE 4.0.0 is delayied in 2 months:
No no no.
It means more bugfixes, more crashes fixed, and a more stable desktop. Those additional 2 months are neccesairy to get stuff working.
If you told people 5 months before the release would be in december, KDE still had to delay it. A release date is needed to focus on making stuff work, otherwise people stay in "thinker mode" instead of "release mode". I'm glad to see how this is handled by the release team so far :)
By Diederik van de... at Sun, 2007/09/02 - 5:00am


text:
|System: Xbox 360, PS3*
|Dev: Capcom
|Pub: Capcom
|Release: August 21, 2012
|Players: 1-2
|Screen Resolution: 480p-1080p
Also to the game's detriment is the fact that there is no way to ban blatantly overpowered characters. Pet Shop is well-known as one of the most broken fighting game characters in existence, and he is selectable like any other. There aren't any balance changes or patches that have been applied to the underlying gameplay system, so you'll find lots of people abusing the heck out of Pet Shop online. Heck, even Third Strike Online let you ban Gill from matches, which makes the lack of a ban function seem like a total oversight.
Graphically, on the other hand, JoJo HD does hold up. Jojo's was one of the prettiest fighting games of its generation, combining manga style drawing with over-the-top animations and effects. Even today, landing Za Warudo into the steamroller crush is enjoyable to look at. You can tweak the options in order to make the game look exactly how you like, and the filters do a good job of smoothing the sprites on HD sets. The added borders that show off character art from the game are also a nice touch. In fact, the only things that aren't nice to look at are the menus. They are spartan, little more than white text on a background. Surely, these could have been jazzed up somehow.
Now, all of this would probably be a value for ten or so dollars. JoJo's was a phenomenal fighting game, and simply getting a chance to play it again is more than worth that money. However, the game is priced at $20, which is about as much as you can expect to pay for a fully stocked HD remake. Is JoJo's worth the money? Honestly, I'd have to say no. It's really not giving you a lot that the originally version didn't already give you. Longtime Jojo's fans will still have their original copy lying around, while newcomers will be unable to get into the game due to the complete lack of tutorials. Not to mention, there's the elephant in the room of online GGPO, which allows any JoJo fan to play the original over the next with better netcode on their computer. For free.
In the end, there's not much that makes JoJo's Bizarre Adventure HD worth the money other than the core gameplay. If getting a chance to play JoJo's Bizarre Adventure again is worth $20 for you, then go for it. Otherwise, this isn't the game for you.
Angelo D'Argenio
Contributing Writer
Date: August 28, 2012
Game Features:


text:
Your journal is quite fantastic. An especially helpful addition would be action plans. Regarding the article Educating India, (Apr. 1999), what can we Vedic people do to help rectify this injustice? Who can we contact? Is there a database of important leaders that we can call, email, fax, etc. to lend our moral, spiritual, emotional and financial support? Insight without action leaves the soul unfulfilled.
Shraddha Mahaveer
* Shraddha, thank you for this excellent suggestion. We try when possible to provide access to action resources. For lists, contact:
a) American Hindus Against Defamation
--Ajay Shah (integral) email@example.com
b) Indian American Intellectuals Forum
--Prof. Romesh Diwan, (integral) email@example.com
c) Foundation for the Advancement of Arts and Sciences of India
--Prof. Ravi Kulkarni (integral) email@example.com
We eagerly wait Hinduism Today's arrival, with its brilliant articles. Your magazine is worth its weight in gold. Choodi Shivaram's Educating India (Apr. 1999) is well researched and succinctly reported. We found one error: "Sri Vishvesha Theertha Swamiji of Pejawar Monastery" is in Udupi, Karnataka State and not in Kerala as printed.
Sunanda and Uppunda V. Bhat
I was very happy to see the March cover story giving so much prominence to ayurveda (Rediscovering Ayurveda, Mar. 1999.) Unfortunately the article was on one institution rather than on ayurveda in general. Your correspondent could have done better justice to the intent to propagate ayurveda by contacting a larger number of institutions and individuals.
P. R. Krishnakumar
Coimbatore, Tamil Nadu, India
I tend to disagree with Maneka Gandhi when she states that "discussion of animal sacrifice should be divorced from religion" (Animal Sacrifice, Apr. 1999.) The root cause of animal sacrifice is the misinterpretation of religion by Hindu priests, who deliberately or ignorantly misguide their clients. Animal sacrifice flies in the face of the basic tenet of Hinduism, ahimsa parmo dharmah ("Nonviolence is the supreme religion"). Even Manu Smriti, often cited to justify animal sacrifice, takes a very dim view of animal slaughter: "Meat can never be obtained without injury to living creatures....shun the use of meat (5.48). He who permits the slaughter of an animal, he who cuts it up, he who kills it, he who buys or sells meat, he who cooks it, he who serves it up, and he who eats it, must all be considered as the slayer of the animals." (5.51)
Pradeep Srivastava
Detroit, Michigan, USA
Readers need a counterweight to the hypothesis that hatha yoga was ever intended to serve the visible purpose of reducing "stress." Yogic postures and "diaphragmatic breathing" are meant for the realization of the Absolute by harnessing dormant powers within the human body and by accumulating tapas. The practice of hatha yoga must be restricted to adherents to the Hindu philosophy that, by intense effort, the individual soul can merge into an impersonal "Ocean of Being." Otherwise we will convert the fabulous gifts of ancient India into a New Age faddish facade, like Chinese T'ai Ch'i Ch'-uan /Chi Kung has become in the absence of any true understanding of Taoist philosophy.
Arun Kapila
Slough, Berkshire, UK
I have seen so many magazines and newspapers of Hinduism but Hinduism Today is the greatest. You have really mastered the balance between beauty and simplicity.
Bala Segaran
"Ayurveda, India's Affordable Health System" (Mar., 1999), prompts me to add that ayuveda can also be the world's health system. An important aspect of this is adapting the ayurvedic energetic model to local herbs and foods. Dr. Vasant Lad and David Frawley started this work years ago. By using local herbs and foods, ayurveda will remain affordable in any country. My own five years experience practicing ayurveda in Europe shows that this local adaptation, in most cases, gives better results to the patient. This shows the greatness, the universal nature and vision of the rishis who developed the methodology of ayurveda, which remains as valid today as ever.
Atreya Smith
During the last two decades, many Hindu temples have come up in America. But temples are custodians of Vedic heritage and have onerous duties, not limited to ritual worship alone. Their real test lies in how far they are able to spread Vedic literacy among the youth. They need spiritual awakening and temples have to fulfill this obligation. Temple trustees need to focus on Vedic literacy through Bal Vihar, Sunday schools, Gita classes. Living in a multi-racial and materialistic Western society, left to themselves, the youth are likely to pursue false identities of life, not relevant to Vedic culture and Hindu ideology.
Ved Vyas Gandotra
Maryland, USA
What a wonderful message to humanity. I am distributing it to all the Southern Christian people who work with me. That Car Won't Bring You Happiness, Minister's Message, (Mar. 1999) They enjoy receiving your Minister's Message whenever I come across such a powerful one. Many acharyas taught "Happiness is in you." But they don't explain what it means. Sushri Siddeshvari Devi correctly identified that Happiness. Devi's simple message to young and old alike is an eye-opener. That part of soul identified with the Brahman is endless bliss which is residing in you. Seek that happiness. My children understood this message and its truth as explained to them in their desire for the materialistic things. I cannot believe a 39-year-old young saint can give such a powerful message that touched our hearts deep inside. I believe it's a God's message through this saint.
Bala Subramanian
* Maneka Gandhi's husband, Sanjay, died in an airplane accident. He was not assassinated as stated on page 34 of our April issue article, Animal Sacrifice.
* The scholar in the white shirt of the second photo of page 33, Om Muruga! (May, 1999 was not Patrick Harrigan, but Alexander Dubianski of Moscow State University.
Letters, with writer's name, address and daytime phone number, should be sent to:
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or faxed to: (808) 822-4351
or e-mailed to:firstname.lastname@example.com
Letters may be edited for space and clarity and may appear in electronic versions of Hinduism Today.
The comments are owned by the author. We aren't responsible for their content.


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Is Nancy Pelosi the dimmest bulb to ever serve in Congress? The most dishonest?? Or both??? In less than fifteen minutes on Fox News Sunday, former Speaker of the House Pelosi said almost more stupid and dishonest things than Joe Biden has hair plugs. But, to preface Ms. Pelosi's lies, prevarications and outright whoppers, we have the dishonest statement from the White House that (federal) budget cuts will result in the "damaging layoffs" of teachers, law enforcement officers and food inspectors.
Really? How many teachers in your public schools are employees of the federal government as opposed to being funded by the cities and communities that their schools are in? And why, you might ask yourself, out of the hundred of thousands of government bureaucracies, departments, employees and expenditures, why it is that every time the public demands a little more financial responsibility from their city, state and federal politicians, that the first thing that happens in return, is a threat to cut police, schools and safety, such as fire, or in this case, food inspection? Let's see a show of hands of all you who think that unnecessary expenditures and waste have been eliminated at every level of government and the only places left to cut are those which affect you most personally? Anyone?? Anyone at all???
The US Department of Education, for example, "currently administers a budget of $68.1 billion in discretionary appropriations" alone. This is in addition to the mandatory budget, which in 2006 was $56 Billion. And to think that for hundreds of years, we educated our kids without sending a single dime to Washington to educate them or expecting Washington to send back a single for it either.
Since Jimmy Carter created the cabinet level Department of Education in 1980, have the nation's test scores improved or continued to slide? Thirty three years of ineffective bureaucratic spending, regulations and pork, with nothing to show for it, except more government intrusion, hundreds of billions of dollars later, and the federal government cannot find any place to cut the budget except food inspectors and the military?
And still, the gems of wisdom have not even begun to fall from Ms. Pelosi's lips! Put on your hip waders, folks, and let us begin!
The first thing I want to point out is the same phony claim that Obama made during the last campaign, that he and the Democrats had "cut $1.6 Trillion" from the budget. Ms. Pelosi repeats the talking point/lie:
"We've had plenty of spending cuts. $1.6 Trillion..."
There is one question that I have been dying to hear anyone in the MSM, or now Fox News, ask of Mr. Obama or Ms. Pelosi:
"You say you've cut the federal budget by $1.6 Trillion dollars. So, in real terms, how many fewer dollars will the federal government spend next year than it did this year?"
If these cuts were more substantive than Monopoly money, then cutting the budget by X amount of dollars should result in spending X amount less than the year before. Right? But all of Obama's budgets and projected budgets increase spending year after year after year. To paraphrase Ms. Pelosi, what she said is not the "gospel truth"*. And speaking of phony, Obama ran all through 2012 claiming we needed a "balanced" approach to the economy, with both spending cuts and tax increases. As soon as he was re-elected, he forgot all about "balance" and pushed for higher taxes, without even any lip service to specific cuts that could or should be made. Need I remind you that in 2008, candidate Obama promised to go through the budget "line by line"** to eliminate waste and unnecessary spending. San Fran Nan used the word "balance" over and over again (it must focus group nicely!), but shied away from actual spending cuts like Dracula from holy water.
Most of us who have or ever had a credit card or loan, know that the only way to decrease the amount of interest we pay is to reduce the balance. We certainly do not decrease interest by increasing spending. But, Ms. Pelosi doesn't think (you could just go with the bold part of this sentence) that we have a "spending problem". Her exact words:
"It is almost a false argument to say we have a spending problem"This is despite Chris Wallace pointing out, that you could confiscate all the wealth of all the wealthy and still not cover our current rate of spending, which would at least imply, to most sane people, that when your spending exceeds your wildest expectations for income, that you have a "spending problem". Ms. Pelosi, despite all your phony budget "cuts", spending continues to increase, making this next statement you made (also without bursting into flames) that much more of a lie:
"We're sick and tired of paying interest on the national debt."
If you were truly sick of it, San Fran Nan, wouldn't you make genuine budget cuts that actually reduce the amount of federal spending, rather than increase it, so that we might some day have the money to pay off the principle, or at least not have to continue to borrow money every day to cover our current spending?
You pretend that all of the problems were inherited from Bush, despite the fact that the really profligate spending started when you became Speaker of the House, which grew exponentially during Obama's first term. You cite pretend jobs that were created by the stimulus spending, when the truth is the US has steadily lost more jobs than were "created" under Obama. And your only solution is to throw even more money at the same failed policies of the past and insanely hope for a different outcome this time? Or do you merely line the pockets of yourself, your family and your cronies, knowing that none of your "solutions" will work, but at least "you've got yours"?
Oh, and one more thing, Nanny Nancy: You claim that monies spent for education are "investments made for the future". We started making "investments" by the billions in 1980 for the Department of Education. We've been making billions of dollars of "investment" in the future for thirty three years. At what point in your personal portfolio do you stop wasting money on investments with no return? Any of them for 33 years? Why don't you accord middle class taxpayers the same courtesy?
*To be honest, I did not catch this the first time I heard the interview. When I did catch it the second time, I was quite frankly surprised that she did not immediately burst into flame.
**"Line by line": Code words for "Somewhere between the first tee and the eighteenth hole"
Cross posted at LCR. The video from the Fox interview posted at LCR, but not here.


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Daily entertainment news with a new episode of "Big Sexy" tonight on TLC, an easy recipe for Quick Sardine Curry and a new website to check out: idiomdictionary.com.
On TV: 'Big Sexy' on TLC at 10 p.m. EDT/ 9 p.m. CDT
Tonight is the series premiere of "Big Sexy." Full-figured New York designers and friends attend Fashion Week and find that while they might be comfortable with their size, others may not agree. But they proudly strut their stuff anyway.
Fun website: IdiomDictionary.com, www.idiomdictionary.com
Idioms – those unique expressions particular to our language – can be pretty strange sometimes. If you're looking for the meaning behind an idiom, say, "the blind leading the blind," check the Idiom Dictionary. There's a definition and example of usage.
Dinner idea: Quick Sardine Curry
1 tablespoon canola oil
1 tablespoon Thai red curry paste, or more to taste
1 clove garlic, minced
1 shallot, minced
1 tablespoon coconut cream, or more to taste
1 (3.75-ounce) can sardines in oil, drained
Heat the canola oil in a skillet. Stir the red curry paste into the hot oil; cook and stir for a few seconds before adding the garlic and shallot. Cook and stir the garlic and shallot until fragrant. Add the sardines; toss around in the pan to brown the skin a little bit and cover it well with the paste mixture. Gently stir the coconut cream into the mixture and continue to toss to coat the sardines. Allow mixture to come to a boil until the sauce thickens, about 5 minutes.
-- allrecipes.com
GateHouse News Service


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This mould features one large oval-shaped cabochon and two smaller oval-shaped cabochons, which create a pendant and earring set. The pendant cabochon is approximately 57 mm (2.25") long, whilst the earrings are approximately 32 mm (1.25") long. Each mould is designed to create a hole in the finished piece, through which a cord or similar can be threaded, so the piece can be hung.
These generic instructions apply to the range of "Holey" jewellery moulds.
For best effect, the manufacturer suggests the use of medium grain frit, or dichroic pieces or stringers, ensuring that any elements used have the same Coefficient of Expansion (COE). The manufacturer also recommends the use of Primo Primer as a glass separator, with the Primo being applied with a small, soft fan brush and in accordance with the manufacturer's instructions. It is important to apply ample primer, and to ensure that any water is driven out of the mould with heat/evaporation before firing with glass. Place approximately 3-6 mm of medium grain frit of your choice in the mould, to act as a base layer. Then place any decorative elements on this base layer of frit, remembering that the glass facing up in the kiln will be the front side or top of the pendant or piece. Fill the mould with another layer of medium grain clear frit (or other transparent frit colour). The mould should be filled to within approximately 1.5 mm of the top of the frit cavity.
Use a clean, small paint brush to sweep the frit away from the frit cavity wall into a peaked mound in the centre of the mould. This will help to prevent frit burrs upon firing. The glass will melt and roll to create a smooth edge in the mould.
Place the filled mould in a kiln and fire in accordance with the following firing schedule supplied by the manufacturer of the moulds.
Segment 1: Ramp at 250 degrees per hour to 600˚ Celsius (1100˚ Fahrenheit) and hold for 5 minutes. Segment 2: Ramp at 250˚per hour to 740˚ Celsius (1360˚ Fahrenheit) and hold for 20 minutes. Segment 3: Ramp at 350˚ per hour to 800˚ Celsius (1470˚ Fahrenheit) and hold for 10 minutes. Then anneal in accordance with the type of glass being used. Once the mould has cooled, it may be necessary to tap gently tap on the side of the mould to remove the glass.
Product 52/95


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More than $1.1 million in state defense funding is headed to Northwest Florida to help bolster military bases, stimulate defense research and provide support for wounded service members.
More than $1.1 million in state defense funding is headed to Northwest Florida to help bolster military bases, stimulate defense research and provide support for wounded service members.
Gov. Rick Scott announced Monday that the Florida Defense Support Task Force awarded grants to four local projects. The task force was created in 2011 to protect the state�s military installations and the defense industry.
�The Florida Panhandle is vital to America�s national security � and we�re committed to supporting the families and communities who serve,� Scott said in a press release.
The task force awarded an additional $1.5 million to six projects elsewhere in the state.
Santa Rosa County received $160,000 to help build a security fence around Naval Air Station Whiting Field.
Improving the security fence was one of the recommendations included in a strategic plan produced for the task force last fall by The Spectrum Group.
The group was commissioned to find ways the state could try to protect its military bases and defense interests against downsizing and closures in a tightened economy. The federal government�s next Base Realignment and Closure process could begin as early as next year.
�This will help protect and enhance Naval Air Station Whiting Field and hopefully make us more competitive in the next base closure round,� said Santa Rosa County Commissioner Don Salter on Monday.
Whiting Field is the county�s largest economic generator. It produces about 3,300 military and civilian jobs and injects about $900 million into the local economy each year.
After The Spectrum Group�s report was released in October, the county asked the task force for money for the project. It was the only funding request the county made to the task force this year, Salter said.
The county is going to match the state�s grant, bringing total funding for the project to $320,000. That is enough to construct a portion of the fence, although Salter does not know the exact footage.
�It will not cover the cost of the entire perimeter fence, but it will make a good start and we will keep asking for additional money in the future until the entire project is complete,� he said.
Several years ago, the county and the Navy partnered to acquire approximately 270,000 acres outside the back entrance to Whiting Field to prevent incompatible development there, such as housing. The county is now working with the base to turn that land into an aviation park that will hopefully include private-sector aviation maintenance companies that could work on base aircraft, Salter said.
The fence will provide a buffer as well as enhance security between the base the aviation park.
The county asked for $200,000 this year, but the request was only partially fulfilled, Salter said.
�I don�t think any community got everything they asked for, but we were very pleased with the $160,000.�
The Andrews Institute in Gulf Breeze was also awarded $225,000 to provide support for wounded special operations warriors.
They plan to use the funds to continue providing intensive restoration therapy to wounded special ops service members to try to get them back to active duty, said Chad Gilliland, chief operating officer for Andrews Institute for Orthopedics and Sports Medicine.
�This grant will help Northwest Florida continue to grow as a leader in providing heath services to our military communities,� he said Monday.
Two additional projects in Northwest Florida also received funding.
The Bay Defense Alliance in Panama City was awarded $500,000 to assist in the acquisition of land to buffer Naval Support Activity Panama City from encroachment.
The Greater Pensacola Chamber will receive $250,000 to establish a center of excellence for information dominance to stimulate science and technology research.
No funds were awarded to projects in Okaloosa County.
An additional $1.5 million went to projects in Jacksonville, Orlando, Tampa Bay and The Highlands area.
Scott said in the press release that Florida is home to nearly 100,000 men and women who serve in active and reserve duty.
There are at least 20 major military installations across the state.
�The military has a strong presence in Florida, which means jobs and opportunities for Florida families,� Scott said in the press release. �These $2.6 million in grants will enhance relationships between Florida communities and the military, to ensure we�re doing the best job possible in working with our nation�s armed forces.�
Contact Daily News Staff Writer Lauren Sage Reinlie at 850-315-4443 or email@example.com. Follow her on Twitter @LaurenRnwfdn.


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Reduced Intensity Donor Peripheral Blood Stem Cell Transplant in Treating Patients With De Novo or Secondary Acute Myeloid Leukemia in Remission
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00045435
Recruitment Status : Completed
First Posted : January 27, 2003
Results First Posted : March 16, 2017
Last Update Posted : January 29, 2020
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome Adult Acute Megakaryoblastic Leukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia in Remission Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Secondary Acute Myeloid Leukemia
|Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation Drug: fludarabine phosphate Radiation: total-body irradiation Drug: cyclosporine Drug: mycophenolate mofetil Procedure: peripheral blood stem cell transplantation
|Phase 2
I. To determine if a one-year disease free survival of >= 35% can be achieved among patients >= 55 years old with de novo and secondary AML in first complete remission (CR1) who undergo nonmyeloablative hematopoietic stem cell transplant (HSCT) from human leukocyte antigen (HLA) identical related donors.
II. To determine if a day +200 nonrelapse related mortality of < 15% can be achieved among patients >= 55 years old with de novo and secondary AML in CR1 who undergo nonmyeloablative HSCT from HLA identical related donors.
CONDITIONING REGIMEN: Patients receive fludarabine phosphate intravenously (IV) on days -4 to -2 and undergo TBI on day 0.
TRANSPLANT: Patients undergo allogeneic PBSC transplant on day 0.
IMMUNOSUPPRESSION: Patients receive cyclosporine (CSP) orally (PO) twice daily (BID) on days -3 to 56 with taper to day 77. Patients also receive mycophenolate mofetil (MMF) PO BID on days 0-27.
After completion of study treatment, patients are followed up on days 28, 56, and 84; months 6, 12, 18, and 24; and then yearly for 5 years.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|17 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|Nonmyeloablative Allogeneic Peripheral Blood Stem Cell Transplantation From HLA Matched Related Donors for Treatment of Older Patients With De Novo or Secondary Acute Myeloid Leukemia in First Complete Remission
|Actual Study Start Date :
|April 2002
|Actual Primary Completion Date :
|January 2009
|Actual Study Completion Date :
|January 2009
Experimental: Treatment (nonmyeloablative donor PBSC transplant)
CONDITIONING REGIMEN: Patients receive fludarabine phosphate IV on days -4 to -2 and undergo TBI on day 0.
TRANSPLANT: Patients undergo allogeneic PBSC transplant on day 0.
IMMUNOSUPPRESSION: Patients receive CSP PO BID on days -3 to 56 with taper to day 77. Patients also receive MMF PO BID on days 0-27.
Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Undergo nonmyeloablative allogeneic PBSC transplant
Drug: fludarabine phosphate
Given IV
Other Names:
Radiation: total-body irradiation
Undergo TBI
Other Name: TBI
Drug: cyclosporine
Given PO
Other Names:
Drug: mycophenolate mofetil
Given PO
Other Names:
Procedure: peripheral blood stem cell transplantation
Undergo nonmyeloablative allogeneic PBSC transplant
Other Names:
- Disease-free Survival-incidence of Survival Without Relapse [ Time Frame: By 1 year after transplant ]Sufficient evidence will be taken to be an observed rate of DFS at one year after transplant that corresponds to a one-sided 95% confidence interval with an upper limit lower than 35%.
- Nonrelapse Mortality (NRM)-Incidence of Nonrelapse Death [ Time Frame: 200 days after transplant ]Defined as death without morphologic evidence of disease. Sufficient evidence will be taken to be an observed rate of NRM within 200 days of transplant that corresponds to a one-sided 80% confidence interval with a lower limit greater than 15%.
- Overall Survival [ Time Frame: By 1 year after transplant ]Percent patients surviving.
- Incidence of Relapse [ Time Frame: By 1 year after transplant ]Percent patients with relapsed disease post-transplant.
- Incidence of Rejection [ Time Frame: By 1 year after transplant ]Percent patients who developed infections post-transplant.
- Incidence of Acute and Chronic GVHD [ Time Frame: aGVHD: 100 days after transplant; cGVHD: 1 Year after transplant. ]Percent patients with acute/chronic GVHD
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|55 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients with de novo AML (French-American-British [FAB] MO-M2, M4-M7) or secondary AML who achieve CR1 after induction chemotherapy and one or two cycles of consolidation chemotherapy
- Transplant conditioning must occur within 6 months of diagnosis
- Patient enrollment must be approved by the Fred Hutchinson Cancer Research Center (FHCRC) principal investigator (PI) or the PI's designee
- DONOR: Related donor who is genotypically or phenotypically identical
- DONOR: Age >= 12 years
- DONOR: Donor must consent to filgrastim (G-CSF) administration and leukapheresis
- DONOR: Donor must have adequate veins for leukapheresis or agree to placement of central venous catheter (femoral, subclavian)
Exclusion Criteria:
- AML involvement of the central nervous system (CNS) as defined by a positive cytospin of cerebral spinal fluid at the time of enrollment
- Presence of circulating leukemic blasts (in the peripheral blood) detected by standard pathology
- Human immunodeficiency virus (HIV) seropositivity
- Fungal infections with radiographic progression after receipt of amphotericin B or active triazole for greater than one month
- Diffusion capacity of carbon monoxide (DLCO) corrected < 40%
- Total lung capacity (TLC) < 40%
- Forced expiratory volume in one second (FEV1) < 40% or requiring supplementary oxygen
- The FHCRC principal investigator of the study must approve enrollment of all patients with pulmonary nodules
- Cardiac ejection fraction < 40%
- Patients with clinical or laboratory evidence of liver disease would be evaluated for the cause of liver disease, its clinical severity in terms of liver function, bridging fibrosis, and the degree of portal hypertension; patients will be excluded if they are found to have fulminant liver failure, cirrhosis of the liver with evidence of portal hypertension, alcoholic hepatitis, esophageal varices, a history of bleeding esophageal varices, hepatic encephalopathy, uncorrectable hepatic synthetic dysfunction evinced by prolongation of the prothrombin time, ascites related to portal hypertension, bacterial or fungal liver abscess, biliary obstruction, chronic viral hepatitis with total serum bilirubin > 3mg/dL, or symptomatic biliary disease
- Karnofsky Performance Score < 70
- Fertile men or women unwilling to use contraceptive techniques during and for 12 months following treatment
- Females who are pregnant or breastfeeding
- No intensive chemotherapy can be given within three weeks (or the interval in which a cycle of standard chemotherapy would be administered in a non-transplant setting) prior to initiating the nonmyeloablative transplant conditioning
- Patients with active non-hematologic malignancies (except non-melanoma skin cancers)
- Patients with a history of non-hematologic malignancies (except non-melanoma skin cancers) currently in a complete remission, who are less than 5 years from the time of complete remission, and have a > 20% risk of disease recurrence
- Patients with active bacterial or fungal infections unresponsive to medical therapy
- DONOR: Identical twin
- DONOR: Pregnancy
- DONOR: HIV seropositivity
- DONOR: Inability to achieve adequate venous access
- DONOR: Known allergy to G-CSF
- DONOR: Current serious systemic illness
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00045435
|United States, Oregon
|OHSU Cancer Institute
|Portland, Oregon, United States, 97210
|United States, Washington
|Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
|Seattle, Washington, United States, 98109
|Principal Investigator:
|Brenda Sandmaier
|Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
|Responsible Party:
|Brenda Sandmaier, Principal Investigator, Fred Hutchinson Cancer Research Center
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
NCI-2011-01307 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
|First Posted:
|January 27, 2003 Key Record Dates
|Results First Posted:
|March 16, 2017
|Last Update Posted:
|January 29, 2020
|Last Verified:
|January 2020
Leukemia, Myeloid
Leukemia, Myeloid, Acute
Neoplasm Metastasis
Leukemia, Monocytic, Acute
Leukemia, Myelomonocytic, Acute
Leukemia, Megakaryoblastic, Acute
Leukemia, Erythroblastic, Acute
Myelodysplastic Syndromes
Neoplasms by Histologic Type
Bone Marrow Diseases
Hematologic Diseases
Neoplastic Processes
Pathologic Processes
Myeloproliferative Disorders
Mycophenolic Acid
Fludarabine phosphate
Antineoplastic Agents
Antimetabolites, Antineoplastic
Molecular Mechanisms of Pharmacological Action
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Enzyme Inhibitors
Antifungal Agents