text:
The University Of Tennessee Memphis
The University Of Memphis
Memphis College Of Art
Crichton College
Education America
Find More information about MEMPHIS, TENNESSEE at wikipedia
All Related CommentsAll related comments for properties in MEMPHIS, TENNESSEE
Hi can you confirm the property you pertaining to?See this property: 5003 DENEEN DR, MEMPHIS, TN
Mary Fri Feb 01, 19 14:06:43
The whole neighborhood is haunted. It used to be Indian land, my neighbor has security camera s and caught 2 shadow 4 legged animal type thing with wing's invgus back yard. Fans turn on and you can hear the button click when you walk by ...fan flew off my dresser to the opposite wall, and worse I was in bed and became paralyzed and felt something on top of me. I couldn't moove or scream for my husband....I had our infant son's crib next to our bed and I vefan praying and was able to use my right arm to pull his crib next to my side of the bed to try to portect him.i felt something try to open my legs and Said the Lord's prayer over and over and it got off of me. I was never a believer till I moved on Deneen Dr.I found out My neighbor down the street sages her house weekly cause she believes there's a evil spirit and has seen a wierd creature in the woods behind my house...the kids cut through there to get to school and saw a decapitated dog with all 4 legs ripped off. I now sage my house and the activity has went down. The entire area is haunted..Horn lake Rd & Holmes Rd area.. especially my neighbor Hood.See this property: 5003 DENEEN DR, MEMPHIS, TN
J.M Fri Dec 01, 17 11:02:21
The people lives at 6244 Cranbury Park Memphis, TN 38141 are gang leaders. Piru..they had put everyone in this street endanger. We wrote the homeowners BURCH WANDA B AND CHARLES BURCH. This is a company. They have over 10 houses with all bad tentant driving down property value so they can come in to buy cheap. This should be against the law. Every month its someone outside this house upset with the gang leader. Screaming and making threats. They need to be removed from this neighborhood. Its a lot of cars now. Its getting bigger. Drive bys are next if the police don't do something ever time people for help.This have been going on for two years. Please move them. We are scarred of the 1am screams of threats and ..PIRU.. GANGSSee this property: 6244 CRANBURY PARK, MEMPHIS, TN
Scared Neighbor Fri Apr 24, 15 04:07:41
I think there is a ghost in this house something is just not rightSee this property: 2547 MACKINNON DR, MEMPHIS, TN
gregory warr Sun Mar 01, 15 12:10:16
5339 is haunted, my husband and I had the house built in 2004.We experienced 3 spirits, 2 adults, 1 male, 1 female, and 1 child a young boy. My youngest daughter witnessed seeing a light come from the great room while in the kitchen, the light traveled up the stairs and transformed into a woman and man.She remembers the man waving at her. I remember feeling the presence in the great room. My son's room was located upstairs, he remembers being choked in his bedroom laying down once he said the name "Jesus" he was let go from the choke.See this property: 5339 BROOKWATER CV SOUTH, MEMPHIS, TN
Tamekia Sun Feb 22, 15 18:45:43
it was bad haunted in the 1970sSee this property: 994 POPE, MEMPHIS, TN
j cox Sat Dec 20, 14 23:18:03
In the yard it's say for rent. Is it for rent or sale? If for rent how much monthly and deposit?See this property: 2694 KATE BOND, MEMPHIS, TN
Kimberly trice Wed Oct 01, 14 17:22:11
Somebody who currently lives there stole my iPhoneSee this property: 3662 IRMA ST. 38127, MEMPHIS, TN
Cam Sun Sep 21, 14 13:14:20
The property is available for rent/sale. No one has lived in it since early JuneSee this property: 4574 TAMMY LANE, MEMPHIS, TN
G. Locke Mon Aug 11, 14 15:33:57
My Dad built this house in the early '30s and we lived there until the early '80s. It caught fire in the early '40s when our next door neighbor's house burned. Dad rebuilt it and made additional improvements on it. It is a shame what has happened to the neighborhood since I was a child and young adult. The people who live in our old home today has really taken good care of it and it looks as good as it did when our family owned it. Mick Bradford 09 June 2014See this property: 3544 MEYERS RD, MEMPHIS, TN
Mick Bradford Mon Jun 09, 14 18:35:20
This place is spider infested and is intruded with uninvited guests.See this property: DORADO COVE, MEMPHIS, TN
anonymous Thu May 22, 14 15:02:35
House is haunted it has been several occation where I seen things in this property occurredSee this property: 809 MARIANNA, MEMPHIS, TN
Anya Harris Tue Apr 29, 14 00:15:56
I grew up in this home (1990-2000). During this time, My family and I experienced many horrifying events. We believe this home to be haunted by several entities. Anyone who moves in, beware!!See this property: 3385 BROWNBARK DR, MEMPHIS, TN
Steph Wed Jan 29, 14 17:05:32
its one of the most beautiful streets in Shelby county and everyone in the cove looks like models.See this property: 4464 RICHMOND OAKS COVE, MEMPHIS, TN
Barny Fife Mon Dec 30, 13 20:17:05
The house is haunted. You hear banging on the walls at anytime of the day til the house shake. You feel something touching you calling your name. There needs to be more research on that house. Some history is hidden on that house and it needs to be brought to the light. Good luck to anyone who stays at that house.See this property: 842 RESTBROOK AVE., MEMPHIS, TN
1ofakind Mon Nov 25, 13 20:52:33
You must be wrong about the address because the lady that is living there has been there since 1952.See this property: 4382 JAMICA DR, MEMPHIS, TN
Ann Fri Sep 20, 13 16:11:47
fire trap and roach motel. two additional building done without permits. not wworth the land it sits on.See this property: 3814 DUNN, MEMPHIS, TN
irene Wed Sep 04, 13 20:30:55
Legend Auto Sales, LLC 3251 Jackson Avenue Memphis. TN 38122 Tel: 901-877-5641 Fax: 901-592-0944 Website: Legendsalesauto.com The best used car sales place in Memphis. TNSee this property: 3251 JACKSON AVENU, MEMPHIS, TN
John Fri Jul 19, 13 16:57:48
I know the people that have stayed in that and they are now still stayin thereSee this property: 3179 MADRID, MEMPHIS, TN
Lexis Tue Jun 25, 13 23:50:14
your all need to mover the yard if not i am going to call the city of memphis or i will move it and you a billSee this property: 6935 TOBIN DR., MEMPHIS, TN
billy prescott Sat Jun 15, 13 10:38:51


text:
Culture Blogs
I was a Jesus Freak, a passionate theologian, and a Southern Baptist minister. I worked hard to convert pagans. The pagans won.
Discovering magic as a witch with an intimate knowledge of western christianity I explore the juxtaposition of these two faiths. Christianity and paganism alike are undergoing dramatic changes with parallel trends, conflicting challenges, and a growing concern for interfaith dialogue.
How I became a Pagan #3 - Storytelling
A few years ago I signed up for OKCupid account and was stumped by the question of what my perfect Friday night looked like. Would I go out for a fancy dinner? Would I go to the movies and see an artsy film? Would I go dancing in a nightclub?
None of this sounded appealing to me. Instead, the perfect Friday night I dreamed of had me sitting around a fire listening to and telling stories. I love stories. I love telling them and I love hearing them. I sometimes remember people by their stories, not their names. Like the child-who-fell-out-the-window-and-bounced-off-a-mosquito-screen-and-survived or the guy-who-spilled-soda-all-over-his-girlfriend-on-their-first-date.*
Witches don't have a monopoly on storytelling; it is part of the Christian tradition in which I was raised. Jesus was a great storyteller. The Hebrew scriptures are full of storytellers, and we did tell stories in my Christian community. We went through familiar bible stories and sought to understand their relevance for our lives today. Sometimes it got old, as in how-to-face-the-Goliaths-in-your-life sermons, but we also found new and exciting angles, background information, and applications for our own lives. And I saw the beauty of the Bible as literature when one of my professors, Ray Lubeck, introduced me to narrative theology.
But my favorite were always the conversion stories. And I don't mean the "testimonies" shared in church, where we'd hear about how Jesus saved someone from drug addiction or provided someone with a parking spot at the mall. I mean the stories that happened outside of church, after the sermon, the testimonies and bible studies. I lived for those times, when people poured out their hearts and got real and talked about their struggles. I remember stories told at campouts or in living rooms, long after we'd all said our goodnights and then stayed up anyways, talking.
I don't know why most of our best stories were told outside of church and late at night. Maybe we felt like we shouldn't talk about the hard stuff at church, or maybe we felt guilty for indulging the self with our personal stories. But those were my favorite parts and I wished we could replace Sunday sermons with that kind of storytelling. I longed for more stories and I didn't know where to find them.
Nowadays I live in a Pagan community and we don't wait until dark to tell stories. I've grown used to having storytellers around and it wasn't until last weekend that I realized how much storytelling played a role in my coming home to Paganism. We were gathered in our ritual room listening to a friend. He talked of his time working in theater, his marriage, his adventures as a bed salesman (I'll leave those to your imagination), and most excitingly, he told stories of Witchcamp.
Witchcamp is an annual Reclaiming retreat in the Redwoods of Northern California. If you haven't heard that I am going this year, consider yourself lucky. I have been talking about little else. In fact, I got so excited about it I accidentally came out to my family, ranting about it IN ALL CAPS on Facebook. The point is, last weekend I realized how excited I was for all of the rituals, the people I would meet, the magickal workings, the time in nature, the drumming and music, but maybe even more so, the storytelling around the fire.
I first realized the importance stories have in the Pagan community in a class I took last year. We had been discussing magickal tools when our teacher surprised us by telling us to "grab a blankie, come closer, and snuggle up". Once she felt we were settled and properly expectant, she pulled out a children's story book and held it up so we could all see the cover. East of the Sun and West of the Moon. A candle flickered on the altar and hundreds of fairy lights illuminated the room as we ooo-ed and aaah-ed. Slowly, theatrically, she opened the cover and let the book sink into her lap. Far away to the north, where the land is covered in thick, dark forests and the wind blows bitterly cold... A dozen adults, sitting in a half circle, eyes closed, listening. It was another moment of coming home, a moment in which the art of storytelling, the need for it, the spiritual practice, was woven into my story.
* both are real people, the former is alive and well today, the latter has been married to said girlfriend for 14 years.
Thursday, 12 June 2014
What a lovely post! Storytelling is such a wonderful part of our lives, whether we are telling time-honoured tales, esoteric myths or our own personal experiences.
I'm looking forward to hearing many more tales from witchcamp in your ritual room!
Thursday, 12 June 2014
I so thank you for sharing..; ] I needed to hear that because I have journeyed a similar path. Story telling is so powerful and you are right about how people are in church with story telling as a pose to telling a harder story outside. We are now living in a shut down society and it's sad this is why the numbers are down in ALL faiths ....thanks again! ; ]
Friday, 13 June 2014
If you're interested, I'm a Pagan Storyteller from Montreal. You can listen to my stories at http://shorteningtheroad.blogspot.ca/
If you click the "story" label, you'll see only the stories I've recorded. I hope you enjoy them!
Saturday, 14 June 2014
There are so many great myths and lore in the community of witches and or pagans. I don't why we don't tell them more often. I love stories, too, particularly reading and listening to them!
Please login first in order for you to submit comments

subset: commoncrawl


text:
- Home
- Gift Cards
- $25 Golf Gift Card
Product Description
An RTJ Gift Card never goes out of style, is easy to wrap and guarantees a smile when opened.
Available in $25, $50, $100 and $200, the gift card can be used at 10 Robert Trent Jones Golf Trail sites and gives your loved ones the freedom to choose whether to use it toward golf or merchandise in the pro shops.
(Not accepted at Lakewood Golf Club)


text:
Langham Hospitality Group
Worldwide - Langham's rapidly expanding portfolio, including The Langham Hotels & Resorts, Cordis Hotels & Resorts, Chelsea Hotel, Toronto, Splash Beach Resort, Mai Khao, Phuket and Eaton HK now spans four continents, covering major gateway cities in both the east and the west.
Earning Airpoints Dollars™ with Langham
Airpoints Dollars™ can be earned at hotels in this group at the following rate:
- The Langham Hotels & Resorts and Cordis Hotels & Resorts when booking a point-eligible rate: A20* per stay**
- Chelsea Hotel, Toronto, Splash Beach Resort, Mai Khao, Phuket and Eaton HK when booking a point-eligible rate: A10* per stay**
How to book
Make your reservation online at The Langham Hotels & Resorts, Cordis Hotels & Resorts, Chelsea Hotel, Toronto, Splash Beach Resort, Mai Khao, Phuket and Eaton HK or alternatively, telephone toll-free (within New Zealand) 0800 880 260 or if you are outside New Zealand, please contact Langham's Worldwide Toll-Free Reservation Call Centres. To earn Airpoints Dollars with Langham Hospitality Group, Airpoints™ Members must make their hotel booking directly with the hotel group and quote or present their Airpoints Membership card when making a reservation and at check-in.
* Members resident in Australia and in Norfolk Island, please note that these earning rates are in New Zealand Airpoints Dollars™, which will be converted to Australian Airpoints Dollars before being credited to your account.
** Some stays are not eligible to earn Airpoints Dollars. Please check with Langham Hospitality Group for more information on qualifying stays and qualifying rates. For further information on Airpoints Dollar eligibility, please see Langham Hospitality Group Programme Partners membership details. Some properties do not participate in the Airpoints™ programme.
Please allow up to 60 days for your Airpoints Dollars to appear in your account. Retain your original receipt or invoice in order to claim any missing Airpoints Dollars. Claims may be made through your Air New Zealand online account by logging into your account and selecting the My Bookings tab, then the Claim missing Airpoints button. You must claim missing Airpoints Dollars within 6 months of your stay.
See the Airpoints™ Terms & Conditions for full details.


text:
Venous Thrombosis and Post-Thrombotic Syndrome: From Novel Biomarkers to Biology
Metz AK, Diaz JA, Obi AT, Wakefield TW, Myers DD, Henke PK. Venous Thrombosis and Post-Thrombotic Syndrome: From Novel Biomarkers to Biology. Methodist DeBakey Cardiovasc J. 2018;14(3):173-181.
Deep vein thrombosis (DVT) is a common disease that carries serious ramifications for patients, including pulmonary embolism and post-thrombotic syndrome (PTS). While standard treatment for DVT is anticoagulation, this carries an added risk of bleeding as well as increased medication monitoring. Identifying those at risk for DVT and PTS can be difficult, and current research with murine models is helping to illuminate the biologic changes associated with these two disorders. Potential novel biomarkers for improving the diagnosis of DVT and PTS include ICAM-1, P-selectin, and cell-free DNA. Inhibition of factor XI, P- and E-selectin, and neutrophil extracellular traps hold promise for novel clinical treatment of DVT. Experimental research on PTS suggests potential cellular and mediator therapy targets of TLR9, MMP-2 and-9, PAI-1, and IL-6. While many important concepts and mechanisms have been elucidated through research on DVT and PTS, more work must be done to translate experimental findings to the clinical arena. The purpose of this review is to examine the currently used murine models of DVT, biomarkers involved in the pathophysiology and diagnosis of DVT and PTS, and potential pharmacologic targets for PTS treatment.Keywords
venous thrombosis; deep vein thrombosis; non-anticoagulant treatment; vascular biology; murine models; biomarkers; post-thrombotic syndrome
Deep vein thrombosis (DVT) is a common disease that most often affects the lower extremities and can result in pulmonary embolism (PE).1 Together, DVT and PE constitute venous thromboembolism (VTE). Between 375,000 and 425,000 people develop VTE each year, resulting in significant morbidity, death, and an annual cost of up to $8 billion.1 The risk of developing DVT increases with age, active cancer, hospitalization, major surgery, and critical illness.2-5 Accurate, expeditious diagnosis of VTE is critical as the condition can be fatal; however, yet anticoagulation carries hemorrhage risk and high costs and should not be administered indiscriminately.
The most common sequela of DVT is post-thrombotic syndrome (PTS), occurring in approximately 40% of patients presenting with a DVT.6 Patients with this condition develop pain, heaviness, swelling, and occasionally ulceration of the affected limb. Post-thrombotic syndrome is characterized by fibrotic injury due to thrombosis-induced inflammation; this results in a thickened and noncompliant vein wall with valvular reflux and often mechanical obstruction that in turn leads to venous hypertension.7,8 The concept of mechanical obstruction has been coined the "open vein hypothesis," and although major efforts have been made to alleviate the obstruction through invasive means, there have been only modest gains.9,10
In 2008, the Acting Surgeon General issued a call to action to prevent VTE by promoting research and new clinical therapies.11 Despite this attention, several challenges still remain, particularly with regard to venous thrombus (VT) resolution and PTS. Major diagnostic and therapeutic gaps include identification of a simple, rapid, low-cost blood test with high sensitivity and specificity to identify patients with acute DVT and those at risk of developing PTS; development of agents that promote DVT resolution without bleeding risks associated with anticoagulation; and an oral or intravenous medication that prevents PTS. While the therapeutic gold standard is based on human drug and device trials, most first efforts rely on murine models.
The purpose of this review is three-fold: (1) to briefly discuss commonly used mouse models of DVT; (2) to review several novel biomarkers that may have a role in the pathophysiology of DVT and PTS; and (3) to review potential pharmacologic targets for the treatment of PTS.
Although they have the same limitations associated with any animal models of disease, murine models provide a relatively consistent way to investigate DVT and PTS. They provide tissue to investigate basic biologic changes associated with VT as well as post-VT vein wall and thrombus changes. Large vein thrombosis does not occur spontaneously in rodents; therefore, several differing models have been developed with variations in blood stasis and endothelial injury to stimulate thrombosis (Table 1).
Inferior Vena Cava Ligation Model
This model uses ligation of the infrarenal inferior vena cava (IVC) to cause total blood stasis.12 Studies in rats suggest that after IVC ligation, a combination of stasis-induced vein wall injury with enhanced tissue factor expression in endothelial cells and leukocytes produce thrombosis.13 This widely used model has provided reproducible thrombus weights beginning at 3 hours and extending to 42 days.12 It has also been valuable in studying interactions between the vein wall and thrombus during the progression from acute to chronic inflammation and remodeling of the vein wall. Disadvantages include the lack of blood flow to test new agents and the inability of the IVC to reopen because of the ligature.
IVC Stenosis Model
This model was initially developed to study early acute thrombosis in a thrombus with morphology similar to the ligation model, although this one permits perithrombus blood flow. The IVC stenosis model narrows the IVC approximately 95% just below the renal veins.14 A disadvantage of this model is the large variation in the size and incidence of VT. Some animals show no evidence of thrombus, whereas in others the vein is completely occluded.
Electrolytic IVC Injury Model
An alternative to the stenosis model, the electrolytic model was first described by Cooley et al. after they used electrolysis to generate VT in a murine femoral vein.15,16 However, the small size of this vessel and thrombus limits the sample size for molecular analysis. A small area of endothelial denudation observed at the needle entry point contributes to thrombus formation, and a laminar thrombus is formed while maintaining a flow channel. Thrombus weights remain consistent with acceptable standard deviations to detect differences in experimental groups, from 6 hours to 14 days post injury.12,17
Brief Pathophysiology of Experimental VT
Although the clotting cascade and its factors are well studied and accepted, several other factors play a role in DVT as determined by the aforementioned VT models. Formation and early resolution of VT is characterized by the influx of neutrophils (PMNs), which promote coagulation by inhibiting anticoagulant factors and releasing neutrophil extracellular traps (NETs) in a process called NETosis.18,19 NETs act as a scaffold for thrombi to adhere to activated platelets and endothelial cells.20 They also allow for the deposition of proteins such as fibrinogen and von Willebrand factor, which further promote thrombogenesis.20
As is characteristic of a sterile inflammatory process, late VT resolution is mediated by monocytes/macrophages that facilitate collagen and matrix remodeling, in part through matrix metalloproteinases (MMPs).21 Several other mechanisms are involved with VT resolution and vein wall injury, including inflammatory chemokines, cytokines, and plasminogen activators and inhibitors.22 Other factors include upregulation of vein wall adhesion molecules such as P- and E-selectin (sel) and also intracellular adhesion molecule-1 (ICAM-1), which mediates the interaction of the vein wall with circulating leukocytes and platelets.23
The P- and E-selectins are involved in the venous thrombogenic process (Figure 1). P-sel is the primary adhesion molecule mediating the initial inflammatory response and plays a key role in chronic inflammation as well. It is present in the platelet alpha granules and endothelial cell Weibel-Palade bodies and is translocated to the plasma membrane.24 The main receptor for P-sel is PSGL-Ig. E-sel is a glycoprotein expressed on activated endothelium that facilitates thrombosis, directly modulating PMN and monocyte activity. Furthermore, E-sel has also been identified as an important regulator of thrombus formation and fibrin content in a mouse VT model.25,26 To further evaluate the role of selectins in the thromboinflammatory response, Myers et al. studied a murine model in which either P-sel, E-sel, or both had been genetically deleted. They found that deletion of E-sel and combined P/E-sel was associated with decreased thrombosis, whereas the inflammatory response in the vein wall was most inhibited in the combined P/E-sel and P-sel groups.25
Several potential biomarkers have been identified within this context, including intercellular adhesion molecule 1 (ICAM-1), P-sel, and NETs (Table 2).
Currently Used Biomarkers
Although useful to rule out the diagnosis of VTE, the use of D-dimer as a biomarker is not as useful to "rule in" the diagnosis since its sensitivity is as high as 98% while its specificity hovers around 60%.27 The use of d-Dimer is well accepted for increasing the pre-test probability if positive, thus it is sensitive but not specific. Another currently used biomarker is factor VIII, the elevation of which may be useful for predicting recurrent DVT.28
ICAM-1 mediates attachment of leukocytes to endothelial cells, allowing the leukocytes to migrate into the tissue during an immune response (Figure 1).29 Serum levels of ICAM-1 may reflect local endothelial and leukocyte activation.30 Experimentally, ICAM-1 has been shown to be mechanistically involved in small vessel thrombosis and large vessel VT in the setting of sepsis in mice.31,32 Several studies evaluating ICAM-1 in the setting of acute DVT found that it lacked the sensitivity or specificity to warrant further investigation.33-35 However, soluble ICAM-1 (sICAM-1) may reflect the severity of PTS.36 In the BioSOX trial that evaluated several inflammatory markers in over 600 patients post thrombosis, elevated sICAM-1 was associated with a risk of developing PTS.36 This was consistent with a previously published study confirming the association of sICAM-1 with development of PTS in 307 patients.37 In both studies, PTS was defined as a Villalta score of ? 5 (moderate severity). Further validation is required to determine if sICAM-1 is a sensitive and specific biomarker for predicting incident moderate to severe PTS.
In humans, elevated levels of soluble P-sel (sP-sel) are common in DVT and VTE.35 Using sP-sel as a biomarker may increase the positive predictive value in patients with a possible DVT, to supplement imaging, or when diagnostic imaging methods are not available (such as at night in many emergency rooms). A study evaluating the use of sP-sel combined with a Wells risk prediction score for diagnosing VTE showed a sensitivity of 91% (low sP-sel and low Wells score to rule out the diagnosis) and a specificity of 98% (high sP-sel and high Wells score to rule in the diagnosis), suggesting this combination may be able to rule in the diagnosis of DVT.27 Thus, the highest sensitivity and specificity may be a combination of sP-sel, a high-sensitivity D-dimer, and the Wells score.38
NETs and Their Metabolites
NETs can be detected in humans by elevated levels of "cell-free" DNA in circulation,39 suggesting potential use of this NET byproduct as a biomarker for diagnosing VTE. However, no studies to date have evaluated NETs or NET byproducts as a biomarker for diagnosing acute DVT.
While major advances have been made using direct oral anticoagulants, the risk of bleeding remains. The most promising new avenues for preventing pathologic clotting are inhibition of factor XI, P/E-sel, and NETs.
Factor XI
Factor XI has procoagulant effects but is not required for hemostasis.40 While it lacks functionality as a biomarker for DVT, factor XI has definite therapeutic potential. It promotes thrombosis through the contact pathway, which occurs when blood comes in contact with an artificial or negatively charged substance, as part of the intrinsic pathway. In a clinical trial of orthopedic surgery prophylaxis, inhibition of factor XI reduced the risk of developing VTE complications post surgery when compared to enoxaparin but did not cause a significant increase in the risk of bleeding.40 Epidemiological studies in a population deficient for factor XI consistently found a significantly lower incidence of DVT when compared to the control population.41 These studies suggest that inhibition of factor XI decreases VTE as effectively as current anticoagulants but without bleeding risk. Strategies to target factor XI include antisense oligonucleotides, aptamers, antibodies, small molecules, and polyanion antagonists.42
Selectin Inhibition
Although not yet tested in large human trials, P-sel inhibition effectively treats established VT in a primate model of iliofemoral VT formation. Two days after thrombus development, baboons were treated with recombinant P-sel glycoprotein ligand-Ig (rPSGL-Ig, 4 mg/kg), low-molecular-weight heparin (LMWH), or saline, and treatment continued once weekly (rPSGL-Ig) or daily (LMWH, saline) based on drug half-life assessment.43 The percent spontaneous vein reopening increased significantly in the proximal iliac vein in animals treated with rPSGL-Ig and LMWH compared with controls. We have also seen the same treatment effect with an aptamer against P-sel that blocks the P-sel:PSGL-1 interaction,44 with improved vein recanalization compared to an aptamer against von Willebrand factor and LMWH, when measured 21 days after thrombogenesis.
Patients homozygous for the S128R E-sel allele, which codes for a more active E-sel, have an increased risk for recurrence of VT.45 Endotoxin-induced, tissue factor-mediated coagulation is enhanced in humans carrying the S128R E-sel allele,46 highlighting the importance of E-sel in VT. We have recently demonstrated that an inhibitor of E-sel treats both murine and patient DVT,47 with essentially no or very limited bleeding potential; this suggests that E-sel may be an excellent target for ongoing VTE trials.
Directly reducing NET formation may offer a safer alternative to anticoagulation treatment by decreasing a prothrombotic factor without compromising hemostasis (Figure 1). Exogenous DNAse has been successful in decreasing VT in animal studies as well as inhibiting the primary NET enzyme called peptidyl arginine deiminase 4.48 While more research is needed, some therapies used to treat VTE, including treatments such as polyanionic heparin and clopidogrel, also affect NETs.49
The primary sequela of DVT is PTS, leading to pain and discomfort in the affected extremity due to venous hypertension. Experimental data has suggested several potential therapeutic avenues that warrant further investigation given the disappointing fact that no medical or surgical therapies currently exist.
Toll-Like Receptor 9
Toll-like receptor 9 (TLR9) is an important host innate immune response receptor that may drive leukocyte promotion of thrombus resolution.50 A study using mice with genetically deleted TLR9 showed a larger thrombus size, suggesting the importance of TLR9 in facilitating thrombus resolution.50 This role of TLR9 points to its potential diagnostic capability in a clinical setting, with a small pilot study showing that patients with lower levels of TLR9 are predisposed to persistent vein wall thickening after a DVT.51 An appealing aspect of this target is the use of an ODN TLR9 agonist (an aptamer) to decrease early VT experimentally in mice,52 which may translate to humans.
Matrix Metalloproteinases-2 and -9
Matrix metalloproteinases-2 and -9 (MMP-2 and -9) are common proteinases that help degrade and remodel the extracellular matrix (ECM) of vessels,21 including degradation of elastin and collagen, and contribute to cellular movement through the ECM.53 These proteinases are found in the vein wall during thrombus resolution, likely originating from monocytes and the vein wall, with MMP-9 activity peaking early post-thrombosis and MMP-2 active during late thrombus resolution.54,55 MMP-9 has been evaluated in one human trial but was not elevated post DVT.35 Data from mice genetically deficient in MMP-2 and MMP-9 showed decreased vein wall injury and preservation of vessel function post-thrombus.56 Although systemic inhibition would likely not be as appealing, targeting an inhibitor localized to the thrombosed vein may hold promise.
Plasminogen Activator Inhibitor-1
Plasminogen activator inhibitor-1 (PAI-1) is a protein found in humans that serves to inhibit protease tissue plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA).57 Genetic deletion of PAI-1 in mice results in dramatically improved VT resolution but at the expense of a fibrotic vein wall.58 Mice that overexpress PAI-1 have large residual thrombi but a relatively preserved vein wall.59 The beneficial effects of PAI-1 overexpression are probably related to the vitronectin-binding domain of PAI-1 that limits the attachment of profibrotic monocytes/macrophages to the vein wall. A unique approach to rapidly resolving thrombi while preventing vein wall injury would be to inhibit the protease function of PAI-1 while allowing the vitronectin-binding domain to function, which at this point is only experimental.
Interleukin-6 Inhibition
Interleukin-6 (IL-6) is a prototypical inflammatory cytokine that is elevated in many disease conditions. It may contribute to thrombus formation by indirectly activating the extrinsic pathway of coagulation,60 although its role is likely multifactorial. Elevated levels of IL-6 or genetic polymorphism may reflect endothelial dysfunction61 and may correlate with the severity of DVT.36 Experimental data has shown smaller VT and decreased vein wall fibrosis in mice undergoing neutralization of IL-6, suggesting IL-6 as a potential mechanism in the development of PTS.62 The IL-6 signaling axis is a clinical target in rheumatoid arthritis, and the drug tocilizumab is efficacious in reducing inflammation and symptoms.63
Much research on DVT is needed with a specific focus on biomarkers for more precision therapy, non-anticoagulant therapy, and PTS. Murine models, with all their inherent limitations, provide the best avenue for developing new knowledge relating to these areas. The prospects closest to human translation are the use of sPsel as a biomarker for incident VTE, factor XI and E-sel inhibition for therapy, and anti-IL-6 pathway for PTS prevention.
Key Points
- VTE is common and is associated with significant morbidity and mortality.
- The primary therapy for VTE is medical, and better diagnostic and predictive markers are needed, with several potentially on the horizon for human translation.
- Post-thrombotic syndrome has no good preventative therapy, and recent aggressive endoluminal and compression interventions have not shown significant benefit.
- More study is needed of PTS, but antifibrotic approaches may be most applicable.
The authors have completed and submitted the Methodist DeBakey Cardiovascular Journal Conflict of Interest Statement and none were reported.References
- Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association. Circulation. 2017;135(10):e146-603.
- Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ 3rd. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998 Mar 23;158(6):585-93.
- Königsbrügge O, Pabinger I, Ay C. Risk factors for venous thromboembolism in cancer: novel findings from the Vienna Cancer and Thrombosis Study (CATS). Thromb Res. 2014 May;133 Suppl 2:S39-43.
- Pannucci CJ, Shanks A, Moote MJ, et al. Identifying patients at high risk for venous thromboembolism requiring treatment after outpatient surgery. Ann Surg. 2012 Jun;255(6):1093-9.
- Obi AT, Pannucci CJ, Nackashi A, et al. Validation of the Caprini Venous Thromboembolism Risk Assessment Model in Critically Ill Surgical Patients. JAMA Surg. 2015 Oct;150(10):941-8.
- Kahn SR. The post-thrombotic syndrome: the forgotten morbidity of deep venous thrombosis. J Thromb Thrombolysis. 2006 Feb;21(1):41-8.
- ten Cate-Hoek AJ, Henke PK, Wakefield TW. The post thrombotic syndrome: Ignore it and it will come back to bite you. Blood Rev. 2016 Mar;30(2):131-7.
- Bergan JJ, Schmid-Schönbein GW, Smith PD, Nicolaides AN, Boisseau MR, Eklof B. Chronic venous disease. N Engl J Med. 2006 Aug 3;355(5):488-98.
- Popuri RK, Vedantham S. The role of thrombolysis in the clinical management of deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):479-84.
- Vedantham S, Goldhaber SZ, Julian JA, et al.; ATTRACT Trial Investigators. Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis. N Engl J Med. 2017 Dec 7;377(23):2240-2252.
- Wakefield TW, McLafferty RB, Lohr JM, Caprini JA, Gillespie DL, Passman MA; Executive Committee of the American Venous Forum. Call to action to prevent venous thromboembolism. J Vasc Surg. 2009 Jun;49(6):1620-3.
- Diaz JA, Obi AT, Myers DD Jr, et al. Critical review of mouse models of venous thrombosis. Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):556-62.
- Zhou J, May L, Liao P, Gross PL, Weitz JI. Inferior vena cava ligation rapidly induces tissue factor expression and venous thrombosis in rats. Arterioscler Thromb Vasc Biol. 2009 Jun;29(6):863-9.
- Humphries J, Gossage JA, Modarai B, et al. Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis. J Vasc Surg. 2009 Nov;50(5):1127-34.
- Diaz JA, Hawley AE, Alvarado CM, et al. Thrombogenesis with continuous blood flow in the inferior vena cava. A novel mouse model. Thromb Haemost. 2010;104(2):366-375.
- Cooley BC. In vivo fluorescence imaging of large-vessel thrombosis in mice. Arterioscler Thromb Vasc Biol. 2011 Jun;31(6):1351-6.
- Diaz JA, Wrobleski SK, Hawley AE, Lucchesi BR, Wakefield TW, Myers DD Jr. Electrolytic inferior vena cava model (EIM) of venous thrombosis. J Vis Exp. 2011 Jul 12;(53):e2737.
- Meng H, Yalavarthi S, Kanthi Y, et al. In Vivo Role of Neutrophil Extracellular Traps in Antiphospholipid Antibody-Mediated Venous Thrombosis. Arthritis Rheumatol. 2017 Mar;69(3):655-67.
- von Brühl ML, Stark K, Steinhart A, et al. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012 Apr 9;209(4):819-35.
- Rao AN, Kazzaz NM, Knight JS. Do neutrophil extracellular traps contribute to the heightened risk of thrombosis in inflammatory diseases? World J Cardiol. 2015 Dec 26;7(12):829-42.
- Deroo S, Deatrick KB, Henke PK. The vessel wall: A forgotten player in post thrombotic syndrome. Thromb Haemost. 2010 Oct;104(4):681-92.
- Henke PK, Wakefield T. Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes. Thromb Res. 2009;123 Suppl 4:S72-78.
- Wakefield TW, Myers DD, Henke PK. Mechanisms of venous thrombosis and resolution. Arterioscler Thromb Vasc Biol. 2008 Mar;28(3):387-91.
- Takada M, Nadeau KC, Shaw GD, Marquette KA, Tilney NL. The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand. J Clin Invest. 1997 Jun 1;99(11):2682-90.
- Myers D Jr, Farris D, Hawley A, et al. Selectins influence thrombosis in a mouse model of experimental deep venous thrombosis. J Surg Res. 2002 Dec;108(2):212-21.
- Sullivan VV, Hawley AE, Farris DM, et al. Decrease in fibrin content of venous thrombi in selectin-deficient mice. J Surg Res. 2003 Jan;109(1):1-7.
- Vandy FC, Stabler C, Eliassen AM, et al. Soluble P-selectin for the diagnosis of lower extremity deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2013 Apr 1;1(2):117-25.
- Timp JF, Lijfering WM, Flinterman LE, et al. Predictive value of factor VIII levels for recurrent venous thrombosis: results from the MEGA follow-up study. J Thromb Haemost. 2015 Oct;13(10):1823-32.
- Frank PG, Lisanti MP. ICAM-1: role in inflammation and in the regulation of vascular permeability. Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H926-H927.
- Isogai N, Tanaka H, Asamura S. Thrombosis and altered expression of intercellular adhesion molecule-1 (ICAM-1) after avulsion injury in rat vessels. J Hand Surg Br. 2004 Jun;29(3):230-4.
- Darbousset R, Thomas GM, Mezouar S, et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood. 2012 Sep 6;120(10):2133-43.
- Obi AT, Andraska E, Kanthi Y, et al. Endotoxaemia-augmented murine venous thrombosis is dependent on TLR-4 and ICAM-1, and potentiated by neutropenia. Thromb Haemost. 2017 Jan 26;117(2):339-48.
- Smith A, Quarmby JW, Collins M, Lockhart SM, Burnand KG. Changes in the levels of soluble adhesion molecules and coagulation factors in patients with deep vein thrombosis. Thromb Haemost. 1999 Dec;82(6):1593-9.
- Bucek RA, Reiter M, Quehenberger P, Minar E, Baghestanian M. The role of soluble cell adhesion molecules in patients with suspected deep vein thrombosis. Blood Coagul Fibrinolysis. 2003 Oct;14(7):653-7.
- Mosevoll KA, Lindas R, Tvedt TH, Bruserud Ø, Reikvam H. Altered plasma levels of cytokines, soluble adhesion molecules and matrix metalloproteases in venous thrombosis. Thromb Res. 2015 Jul;136(1):30-9.
- Rabinovich A, Cohen JM, Cushman M, et al. Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome. J Thromb Haemost. 2015 Mar;13(3):398-408.
- Shbaklo H, Holcroft CA, Kahn SR. Levels of inflammatory markers and the development of the post-thrombotic syndrome. Thromb Haemost. 2009 Mar;101(3):505-12.
- Wells PS, Anderson DR, Rodger M, et al. Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis. N Engl J Med. 2003 Sep 25;349(13):1227-35.
- Diaz JA, Fuchs TA, Jackson TO, et al. Plasma DNA is Elevated in Patients with Deep Vein Thrombosis. J Vasc Surg Venous Lymphat Disord. 2013 Oct 1;1(4):341-348.e1..
- Weitz JI, Fredenburgh JC. Factors XI and XII as Targets for New Anticoagulants. Front Med (Lausanne). 2017 Feb 24;4:19.
- Salomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U. Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis. Thromb Haemost. 2011 Feb;105(2):269-73.
- Weitz JI, Fredenburgh JC. 2017 Scientific Sessions Sol Sherry Distinguished Lecture in Thrombosis: Factor XI as a Target for New Anticoagulants. Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):304-10.
- Myers D, Wrobleski S, Londy F, et al. New and effective treatment of experimentally induced venous thrombosis with anti-inflammatory rPSGL-Ig. Thromb Haemost. 2002 Mar;87(3):374-82.
- Diaz JA, Wrobleski SK, Alvarado CM, et al. P-selectin inhibition therapeutically promotes thrombus resolution and prevents vein wall fibrosis better than enoxaparin and an inhibitor to von Willebrand factor. Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):829-37.
- Jilma B, Kovar FM, Hron G, et al. Homozygosity in the single nucleotide polymorphism Ser128Arg in the E-selectin gene associated with recurrent venous thromboembolism. Arch Intern Med. 2006 Aug 14-28;166(15):1655-9.
- Jilma B, Marsik C, Kovar F, Wagner OF, Jilma-Stohlawetz P, Endler G. The single nucleotide polymorphism Ser128Arg in the E-selectin gene is associated with enhanced coagulation during human endotoxemia. Blood. 2005 Mar 15;105(6):2380-3.
- Culmer DL, Dunbar ML, Hawley AE, et al. E-selectin inhibition with GMI-1271 decreases venous thrombosis without profoundly affecting tail vein bleeding in a mouse model. Thromb Haemost. 2017 Jun 2;117(6):1171-81.
- Fuchs TA, Brill A, Wagner DD. Neutrophil extracellular trap (NET) impact on deep vein thrombosis. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1777-83.
- Kimball AS, Obi AT, Diaz JA, Henke PK. The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis. Front Immunol. 2016 Jun 27;7:236.
- Dewyer NA, El-Sayed OM, Luke CE, et al. Divergent effects of Tlr9 deletion in experimental late venous thrombosis resolution and vein wall injury. Thromb Haemost. 2015 Nov;114(5):1028-37.
- Deatrick KB, Elfline M, Baker N, et al. Postthrombotic vein wall remodeling: preliminary observations. J Vasc Surg. 2011 Jan;53(1):139-46.
- Henke PK, Mitsuya M, Luke CE, et al. Toll-like receptor 9 signaling is critical for early experimental deep vein thrombosis resolution. Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):43-9.
- Deatrick KB, Eliason JL, Lynch EM, et al. Vein wall remodeling after deep vein thrombosis involves matrix metalloproteinases and late fibrosis in a mouse model. J Vasc Surg. 2005 Jul;42(1):140-8.
- Sood V, Luke CE, Deatrick KB, et al. Urokinase plasminogen activator independent early experimental thrombus resolution: MMP2 as an alternative mechanism. Thromb Haemost. 2010 Dec;104(6):1174-83.
- Deatrick KB, Obi A, Luke CE, et al. Matrix metalloproteinase-9 deletion is associated with decreased mid-term vein wall fibrosis in experimental stasis DVT. Thromb Res. 2013 Sep;132(3):360-6.
- Deatrick KB, Luke CE, Elfline MA, et al. The effect of matrix metalloproteinase 2 and matrix metalloproteinase 2/9 deletion in experimental post-thrombotic vein wall remodeling. J Vasc Surg. 2013 Nov;58(5):1375-1384.e2.
- Obi AT, Diaz JA, Farris DM, et al. Vitronectin Gene-deletion, PAI-1 Gene-deletion, and LMWH Treatment: Effect on Thrombus Resolution and Vein Wall Remodeling in a Mouse Model of DVT. J Vasc Surg Venous Lymphat Disord. 2013 Jan;1(1):103.
- Baldwin JF, Sood V, Elfline MA, et al. The role of urokinase plasminogen activator and plasmin activator inhibitor-1 on vein wall remodeling in experimental deep vein thrombosis. J Vasc Surg. 2012 Oct;56(4):1089-97.
- Obi AT, Diaz JA, Ballard-Lipka NL, et al. Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism. J Thromb Haemost. 2014 Aug;12(8):1353-63.
- Hou H, Ge Z, Ying P, et al. Biomarkers of deep venous thrombosis. J Thromb Thrombolysis. 2012 Oct;34(3):335-46.
- Matos MF, Lourenco DM, Orikaza CM, Bajerl JA, Noguti MA, Morelli VM. The role of IL-6, IL-8 and MCP-1 and their promoter polymorphisms IL-6 -174GC, IL-8 -251AT and MCP-1 -2518AG in the risk of venous thromboembolism: a case-control study. Thromb Res. 2011 Sep;128(3):216-20.
- Wojcik BM, Wrobleski SK, Hawley AE, Wakefield TW, Myers DD Jr, Diaz JA. Interleukin-6: a potential target for post-thrombotic syndrome. Ann Vasc Surg. 2011 Feb;25(2):229-39.
- McInnes IB, Thompson L, Giles JT, et al. Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study. Ann Rheum Dis. 2015;74(4):694-702.


text:
Unsecured business loans
If you want a business loan without offering security, an unsecured business loan might be just what you're looking for.
Unsecured loans are a great funding option for businesses that don't own many assets, businesses that would prefer not to offer security, or any company that's growing fast and needs finance quickly.
With a variety of lenders on the market able to offer unsecured loans up to £250,000, there are options for a wide variety of situations. Read more to find out how an unsecured loan could help your business.
What is an unsecured business loan?
It's a loan that doesn't require security. A secured loan uses assets as security — which means if things don't work out, the lender can sell the assets to recoup the cost of the loan. The question of 'secured vs. unsecured loans' is really all about risk for the lender.
Business loans without security
To consider a secured loan, you have to have security in the first place. But if you don't have any assets, you'll need to get a loan without security — an unsecured business loan.
These days, more and more companies are based on intangible assets — for example, if you're a software or consultancy company you're likely to have a rented office, a few computers, and not much else in terms of tangible assets. That's where unsecured business loans come in.
In the world of alternative finance there are lots of lenders who can lend upwards of £100,000 unsecured — even up to £250,000 in the right circumstances. Because there's no security, trading history becomes more important and the lender might ask for a personal guarantee too.


text:
Dog food reviews
Member List
Dry Dog Foods
4 Star Premium Dry Food
Previous Product
Next Product
Blue Buffalo Lamb & Brown Rice for Puppies
Date of last review
Wed January 4, 2006
Recommended By
Average Price
Average Rating
100% of reviewers
None indicated
None indicated
Calorie Content (ME):
Kcal/Kg = 3,539.5 (calculated)
Kcal/Cup = 554.1 (as fed)
Deboned Lamb, Lamb Meal, Whole Ground Brown Rice, Whole Ground Barley, Fish Meal, Oatmeal, Rye, Whole Potatoes, Sunflower Oil (natural source of Omega 6 Fatty Acids), Tomato Pomace (natural source of Lycopene), Natural Flavor, Whole Carrots, Whole Sweet Potatoes, Blueberries, Cranberries, Flaxseed, Barley Grass, Dried Parsley, Alfalfa Meal, Kelp Meal, Taurine, L-Carnitine, L-Lysine, Glucosamine Hydrochloride, Yucca Schidigera Extract, Green Tea Extract, Turmeric, Garlic, Herring Oil (natural source of Omega 3 Fatty Acids), Fructooligosaccharides, Monooligosaccharides, Dried Chicory Root, Black Malted Barley, Oil of Rosemary, Vitamin A Supplement, Vitamin C, Vitamin E Supplement, Vitamin D3 Supplement, Beta Carotene, Calcium Ascorbate (source of Vitamin C), Vitamin B12 Supplement, Niacin (Vitamin B3), Calcium Pantothenate (Vitamin B5), Riboflavin (Vitamin B2), Pyridoxine Hydrochloride (Vitamin B6), Thiamine Hydrochloride (Vitamin B1), Folic Acid, Biotin, Choline Chloride, Calcium Phosphate, Zinc Amino Acid Complex (source of Chelated Zinc), Iron Amino Acid Complex (source of Chelated Iron), Copper Amino Acid Complex (source of Chelated Copper), Manganese Amino Acid Complex (source of Chelated Manganese), Potassium Amino Acid Complex (source of Chelated Potassium), Cobalt Proteinate (source of Chelated Cobalt), Potassium Chloride, Sodium Selenite, Salt, Lactobacillus acidophilus, Bacillus subtilis, Bifidobacterium thermophilum, Bifidobacterium longum, Enterococcus faecium.
Guaranteed analysis:
Crude Protein 26.0% min
Crude Fat 14.0% min
Crude Fiber 4.5% max
Moisture 10.0% max
Calcium 1.6% min
Phosphorus 1.1% min
DHA* 0.1% min
Omega 3 Fatty Acids* 0.6% min
Omega 6 Fatty Acids* 2.0% min
*Not recognized as an essential nutrient by AAFCO Dog Food Nutrient Profiles.
Post a Reply
Registered: October 2005
Posts: 3953
Review Date:
Wed January 4, 2006
Would you recommend the product?
| Price you paid?:
Not Indicated
| Rating:
First two ingredients are named meat products, uses primarily good quality grains and whole vegetables, minimal filler
Minimum acceptable meat content, some filler
The first ingredient in the food is a named meat product, as is the second. Since the first is lamb inclusive of its water content (about 80%) and once that is removed it is likely that this ingredient would be more accurately placed somewhat further down the ingredient list (ingredients are listed in order of weight). Note that this is an example of the practice of splitting (see note on main page), but in this case serves to increase our level of confidence in the amount of meat product in the food.
Fish meal is the 5th ingredient in the food, and a further meat ingredient although this is a little too far down the ingredient list to make up a substantial portion of the food. We note that the manufacturer does not claim to use ethoxyquin-free sources (ethoxyquin is a chemical preservative commonly added to fish destined for meal, and is believed to be carcinogenic).
There are four grains in the food ahead of the oil content. All are decent quality grains, but the food starts to appear grain-heavy. Tomato pomace is filler, but we appreciate the use of whole vegetables in the food. There is a good range of probiotics also.
Overall this is a reasonably good food, and unlike the other formulas of the brand, does not include controversial ingredients such as beet pulp.
Powered by:
Copyright 2006 All Enthusiast, Inc.
Trusted Gourmet
Terms of use
Privacy policy
Copyright © 2005 - 2009 DogFoodAnalysis.com.
All Rights Reserved.
Mesure d'audience ROI statistique webanalytics par


text:
Vietnamese Green Mango Salad/ Goi Xoai
Yields: 4 - 6 servings
For the salad:
3 green mangoes, cut into matchsticks
1/4 cup dried shallots, fried
1/2 cup vietnamese coriander (rau ram), chopped
1/4 cup sliced onions
1/2 cup peanuts, toasted and roughly chopped
20 medium shrimp, shelled and de-veined
For the sauce: (makes much more than needed for the salad)
5 cloves garlic, minced
1/4 cup vegetable oil
1/2 cup fish sauce
1/4 cup sugar
1/3 cup lime juice
In a large bowl, toss together all of the ingredients for the salad. To make the sauce, heat the oil over medium heat. Add the garlic and fry until golden. Lower the heat to medium-low and add the fish sauce, sugar. Boil until the sugar is dissolved, let cool slightly, then add the lime juice. Add more sugar if needed. Heat a grill over medium-high heat. Season the shrimp with some salt, pepper and olive oil. When the grill is hot, add the shrimp and cook on both sides until done, about 3 minutes each side. When ready to eat, divide the salad among the serving dishes and top with shrimp. Drizzle each serving with 1 - 2 tsp. of the dressing.


text:
Apple sent its much coveted invitation for an Oct. 4 press even to reporters Tuesday morning.
"Let's talk iPhone" it says, next to a clever graphic with an iPhone calendar, clock and map indicating a 10 a.m. start time at its Infinite Loop campus.
It will be the first post-Steve Jobs event. And the rumor mill has it that we will be introduced to the iPhone5. Both of those things are seen as a big deal for the company.
But the venue choice makes things interesting.
U.S. & World
News from around the country and around the globe
Careful Apple observers point out Apple doesn't use its own campus theater for presentations very often. Events at the Apple theater tend to be smaller. For example it was the place where they introduced the iPod speaker. The company also held its press conference there following "Antennagate."
There are a number of disadvantages to that theater: Its smaller size means some reporters must be excluded from the event and it can be disruptive to regular Apple employees.
So why is Apple making its next presentation on campus?
There are a number of theories. The first is the fact because this will be Tim Cook's presentation as Apple CEO, the company wants to keep the event small. It could be the improvement to the iPhone is so incremental it does not warrant a huge venue.
Could it be Apple's next iPhone isn't the iPhone 5, but an iPhone 4G instead? Best Buy apparently think so -- as this leaked inventory report seems to indicate.
So why keep it a small venue? Because Apple could demonstrate the 4G functionality using a self-contained cell phone system -- the kind you'd only find on the company's own campus.
Apple after all ran into trouble with network connectivity at past events like the introduction of the iPhone 4. "So you guys have a choice: Either turn off your Wi-Fi or I give up," Jobs said at the event, as he searched for a Wi-Fi connection for the demonstration.
We'll live blog the Apple event Tuesday morning so keep an eye on this space.


text:
Our Team
Standing for something bigger than ourselves.
People who care helping people who care.
We're a growing team of dedicated individuals working together to transform giving. Want to Join Us?
Our Founders
Scot Chisholm
Pat Walsh
Chief Impact Officer
Joe Callahan
VP, Design
Marshall Peden
Director, Customer Care
Our Leadership
Neena Gupta Needel
Chief Product Officer
Dina Rulli
SVP, People
Adam Aarons
CRO & President
Soraya Alexander
SVP, Marketing
Jason Mitchell
SVP, General Counsel
Sarah Jennings
SVP, Sales
Mike Granieri
EVP, Sales
Our Advisors
Suzanne DiBianca
Chief Philanthropy Officer, Salesforce
Scott Harrison
CEO & Founder, charity:water
Alex Bard
Partner, Redpoint Ventures
Adam Braun
Founder, Pencils of Promise
Jenny Abramson
Founder & Managing Partner, Rethink Impact


text:
You are here
The Beach Body Boot Camp Diet: Breakfast Choices
Shrink your waist and lose inches all over with our Beach Body Boot Camp meal plan. Each of these healthy breakfast recipes clocks in under 300 calories.
Peter Ardito
Lemon-Raspberry Fruit Salad
- Combine 1/4 cup part-skim ricotta and 1 teaspoon raspberry jam.
- Mix together 1 cup fresh raspberries, 1 tablespoon fresh lemon juice, 1 teaspoon lemon zest, and 2 teaspoons honey.
- Top ricotta mixture with raspberry mixture and sprinkle with 2 tablespoons toasted sliced almonds.
Peter Ardito
Mushroom and Asparagus Quiche
- Preheat oven to 350 degrees F.
- Whisk together 3 eggs plus 2 egg whites; mix in 1/2 cup chopped asparagus, 1/2 cup chopped mushrooms, and 1/4 cup shredded Swiss cheese.
- Pour mixture into 6 muffin cups coated with nonstick cooking spray.
- Bake 20 to 25 minutes, until eggs are set.
- Eat 3 mini quiches with 1 slice toasted whole-grain bread and an orange. (Save the rest for another breakfast.)
Peter Ardito
Breakfast Peach Cobbler
- Chop 1 peach into 3/4-inch pieces; mix with 1 tablespoon whole wheat flour and 1/2 teaspoon cinnamon.
- Microwave 2 to 3 minutes and stir.
- Add 1 crunchy granola bar (around 90 calories), broken into pieces, and microwave 1 minute.
- Top with 1/2 cup low-fat Greek yogurt and 2 teaspoons honey.
Peter Ardito
Baked Eggs with Herbs
- Preheat the oven to 350 degrees F. Coat a 6-ounce ramekin with nonstick cooking spray.
- Crack 2 eggs into prepared ramekin and top with 2 tablespoons low-fat milk, 1 tablespoon chopped fresh chives, 1 tablespoon chopped fresh basil, and a pinch each of salt and black pepper.
- Bake about 15 minutes, until eggs are set.
- Serve with melon and 1 slice toasted whole-grain bread topped with 1 teaspoon butter.
Peter Ardito
Banana-Nut Protein Pancakes
- In a blender, combine 1 banana, 1/4 cup rolled oats, 2 tablespoons low-fat cottage cheese, 2 egg whites, and 1/2 teaspoon vanilla extract; blend until smooth.
- Stir in 2 teaspoons chopped walnuts.
- Heat a large skillet over medium heat and coat with nonstick cooking spray.
- Pour batter into skillet to make two 4-inch pancakes; cook 3 minutes on each side.
- Drizzle with 2 teaspoons maple syrup.
Peter Ardito
Tex-Mex Tofu Scramble
- Mash 3 ounces drained firm tofu with a fork.
- Heat 1 teaspoon olive oil in a medium skillet over medium heat and saute tofu and 1/8 teaspoon turmeric 3 minutes.
- Add 1/4 cup salsa and 1/4 cup canned black beans, rinsed and drained; saute 5 minutes.
- Top with 2 tablespoons chopped cilantro and serve with 1/2 grapefruit and 1 slice toasted whole-grain bread topped with 1 teaspoon butter.
Peter Ardito
Waffles with Blueberry Syrup and Turkey Sausage
- In a blender, combine 1/2 cup frozen unsweetened blueberries, thawed, and 1 tablespoon maple syrup; puree until smooth.
- Heat 1 turkey sausage link in the microwave.
- Toast 2 frozen whole-grain waffles and top with syrup mixture.
- Serve with sausage.
Peter Ardito
Get More Slimming Meals
Mix and match these lunches, dinners, and snacks for a total of 1,500 calories a day. Combine it with our Beach Body Boot Camp workout plan and you'll shed 10 pounds in one month!
Get Lunch Recipes Under 400 Calories
Get Dinner Recipes Under 500 Calories


text:
Washington D.C., Aug 9, 2013 / 05:51 pm MT ().- A young Catholic blogger known for his defense of the faith in the public square is thankful for prayers and support as he begins the long process of recovery following a severe accident.
"Rehabilitation will not be easy and there are no answers for how much Thomas will be able to rehabilitate," said Natalie Peters in a statement collaborated with Thomas, her husband.
However, she told CNA that she and Thomas "have been overwhelmed by the outpouring of prayers" and encouragement coming from family, friends and supporters in the weeks since his accident.
A leader in the Catholic community, Thomas Peters starting the award-winning blog "The American Papist" in 2006 before joining the group Catholic Vote in 2010. The 27-year-old became one of a few American bloggers invited to the Vatican's first blogger meeting in Rome. Peters also works as communications director and blog manager for the National Organization for Marriage.
On July 16, Peters was injured in an accident while swimming in Maryland, fracturing his fifth cervical vertebra, which is located in the lower neck. He is in "critical but stable condition," according to the recovery website set up by family and friends.
Because of the location of the damage, the injury has had an impact on Peters' sensation, strength and mobility, particularly in his fingers. While he has regained the use of his wrists, there "is no firm prognosis for his long term mobility," the website said.
The accident also left water in Peters' lungs, leaving them weak. As a result, he has been on a ventilator since the accident, although he is now sitting and breathing on his own for hours at a time in order to strengthen his diaphragm and chest muscles.
In addition, Peters has undergone a tracheotomy and had a head brace installed for stability. Surgery will be required to fix the fracture, though the doctors will not be able to operate until an infection that formed at his tracheotomy site heals.
Despite the trials and challenges posed by the injury, Natalie explained that they "are committed to staying hopeful."
According to the recovery blog, Thomas "is calmer, happier, better when Natalie is around." Natalie helps her husband in completing daily tasks, such as shaving and washing his hair, while he gradually recovers his ability to do certain tasks on his own, such as holding tubing and other objects.
In addition, the couple strives to stay in high spirits between physical therapy and appointments. Natalie reads and responds to emails and letters, Thomas tells jokes, and the pair watches some of their favorite television shows and movies.
They have also been joined in prayer by family and friends, including several priests. Thomas has received the sacrament of the Anointing of the Sick, and is able to pray and receive the other sacraments frequently while in the hospital.
Supporters have set up a spiritual bouquet website to collect prayers for Peter, along with a Facebook prayer page and a novena to Servant of God Luisa Piccarreta, a 19th century Italian laywoman who spent much of her life bedridden with infirmities.
The Peters family has expressed gratitude for the outpouring of support – especially prayers – that they have received in the weeks following the accident.
"We feel the power and grace of these prayers every day," Natalie said.
Friends have also organized an Aug.14 benefit concert by musician Luke Spehar at the Catholic Information Center in downtown Washington, D.C., to help raise funds for Peters' medical bills and other needs.
"We're so thankful to Luke Spehar for performing, which will allow us the opportunity to gather as a community in support of the Peters family, who continue to be an inspiration to so many of us in the Washington area and around the country," said Mitch Boersma, Chief Operating Officer of the Catholic Information Center.
Natalie encouraged those who wish to follow her husband's recovery to do so through the blog. She also called on supporters to "get involved in the causes that we care about," noting that Thomas "cares about getting the word out" on these critical social issues.
"Most importantly," she added, "please continue to pray for us!"
Tags: Catholic vote, Marriage, Catholic community, Blog
You may also like »
Catholic author encourages prayers for souls in purgatory
Though purgatory can be considered strictly a place of punishment, author Susan Tassone...
Catholic bishops offer prayers for royal baby
Catholic bishops in the United Kingdom offered their congratulations and prayers for...
Pope Francis calls Syro-Catholic patriarch, assures of his prayers
According an Italian Catholic new organization, Pope Francis made a phone call to Patriarch...


text:
You say all the world is a stage? Got that right, especially in summer, when standing ovations happen from ski hill to lakeshore, level turf to hilltop.
In gambling, a trifecta is the first three finishers of a race, selected in exact order. Here are three of Wisconsin's top venues for outdoor theater, but you decide the order that best suits your interests and budget.
Each rural performance space presents distinctively different entertainment. Dress casual and don't bother wearing spiky heels to any of these earthy locations.
Name, location: American Players Theatre, 5950 Golf Course Rd., Spring Green.
In one sentence: A roofless theater blends seamlessly with nature on 110 acres of woods, fields and hills.
Capacity: 1,148.
Now playing: Shakespeare's "Hamlet" to Somerset Maugham's "Too Many Husbands." Five classics are staged outdoors in rotating repertory until Oct. 20.
Coming soon: What plays when depends upon the day.
Last call: "Les Liaisons Dangereuses," a risqué French comedy, 6 p.m. Nov. 24 at the 200-seat, indoor Touchstone Theatre, which has a three-play season on this campus.
Ticket prices: $42-$68.
History lesson: Founders considered 43 outdoor locations before opening in 1980 at this former farm.
Concessions: Pack your own picnic or pre-order a spread of meats, cheeses, salads, sweets to feed two or a crowd. It's fine to add wine, available by the bottle, glass or from your own stash – but the toasts must end when the walk uphill begins.
Best souvenir: handcrafted jewelry, nature-themed art, T-shirts with clever literary slogans.
Quick trivia: APT's history includes a Tony Award nomination for Outstanding Regional Theater.
Extra bonus: the occasional full moon and impromptu cameos by bats, birds or other wildlife.
Insider tip: The actors are pros, but the ushers are volunteers. Hint, hint.
For more details: americanplayers.org, 608-588-2361.
Name, location: Big Top Chautauqua, 32525 Ski Hill Rd., Bayfield.
In one sentence: Nationally known performers, plus an inhouse orchestra, take the stage under a canvas tent erected at the base of a ski hill.
Capacity: 880 under cover, but 2,000-plus with tent flaps up.
Now playing: The lineup that remains includes National Public Radio's Ira Glass (Aug. 31), acoustic guitarist Leo Kottke (Sept. 1) and folk-rockers the Indigo Girls (Sept. 8).
Coming soon: A new tent will replace the seven-year-old canvas that was damaged by storms and patched back together earlier this year.
Last call: Big TAP Chautauqua Fest, a craft beer showcase, closes the season Sept. 14.
Ticket prices: free to $99.
History lesson: Co-founder Warren Nelson, who made a comeback this year with the debut of his "Play Ball" history-music production, ran with the tent show concept in 1960 because "culture under the tent" was a fast-vanishing tradition.
Concessions: Available by reservation is the Taste of Bayfield Bento Box, which contains smoked fish, goat cheese, seasonal fruits, fudge and more. Traditional fare includes brats, beer.
Best souvenir: CDs of Blue Canvas Orchestra music.
Quick trivia: Host Michael Perry also is a registered nurse, pig farmer and bestselling author (whose works include "Population 485").
Extra bonus: A free shuttle makes stops in Red Cliff, Bayfield, Washburn and Ashland.
Insider tip: If you miss a favorite performer, check out Tent Show Radio rebroadcasts, which air nationwide.
For more details: bigtop.org, 715-373-5552.
Name, location: Peninsula Players Theatre, 4351 Peninsula Players Rd., Fish Creek.
In one sentence: It is not unusual for this open-air, 16-acre, lakefront venue in a Door County cedar forest to premiere new and unconventional plays.
Capacity: 621.
Now playing: "The Game's Afoot," a zany whodunit in which the actors play actors, and each is a logical suspect. Ends Sept. 1.
Coming soon: "Miracle on South Division Street," opening Sept. 4.
Last call: "Miracle on South Division Street," Oct. 20.
Ticket prices: $34-$43.
History lesson: No summer theater for professional actors who reside on the grounds is older in America. The first show, in 1935, was "Hay Fever" by Noel Coward.
Concessions: Match an assortment of artisan cheeses with a drink at the onsite Luna Bar, which serves various libations.
Best souvenir: Buy a Players mug for a bottomless cup of coffee whenever you visit.
Quick trivia: Very few non-union actors are used, but these auditions happen annually in Chicago.
Extra bonus: Time it right, and you'll witness a spectacular sunset before the curtain rises.
Insider tip: Cozy up to the bonfire during intermission.
For more details: peninsulaplayers.com, 920-868-3287.


text:
Maulena necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 152 diseños de 44 diseñadores freelance.
The Planroom Connection By F2O
Woman starting a new business in the construction industy. A planroom that will offer Contractors the ability to come in a use plans to bid off of, or use the virtual planroom. In addition, we offer a "Network" "Connection" type of environment that allows Contractors to come in a use the open wifi area, fax - a office away from their office. In addition, we have in house affiliates that will offer insurance services, admin services, bookkeeping, financial planning. Everything a contractor will need to obtain work and run it properly. Connecting with Architects, General Contractors, Home Owners etc..Key word for me is CONNECTION.
Construction - Owners, Developers, Architects, Engineers, General Contractors, Construction Managers, Subcontractors, and any and all construction associated businesses and professionals.
Requirements: We are looking for a logo that represents our company – The Plan Room Connection By F20 please see the overview section for more information about our company.
1. The logo needs to appeal to both men and women in the construction industry.
2. The logo needs to be able to easily reproduced on the website and on print material.
3. The corporate website will incorporate earthy colors (beige, green, tan), so the logo colors will need to complement earth tones.
4. An icon that plays coveys a feeling of "Connection".
5. Font to be used can be "Myriad Pro" or similar.
6. Emphasis should be on the words "The Plan Room Connection", the words "By F20" should be de-emphasized.
I want something that conveys connection, with people and business. No cartoons or over the top. Strong, down to earth connection. Clear and concise. Not over done.
Please do not use any stock images or clip art in the logo
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


text:
Microsoft's 'Linux Threat Level': Down to Green or Redder Than Ever?
Aug 15, 2011 5:00 AM PT
Now that Microsoft wants to be Linux's new best friend, there's bound to be no end of sweet nothings and touching gestures emanating out of Redmond.
After all, we're pals now, right?
Lo and behold! For all you skeptics who doubted the software behemoth's amorous words, consider a few phrasing changes it recently made in its last two annual financial filings.
'So Much for All Those Predictions'
Whereas said documents used to include Linux as a primary threat to Windows -- alongside Apple and Google -- Redmond's documents now reportedly don't mention any competitive threat from desktop Linux at all, according to a recent article on Business Insider, which cites a tweet by Directions on Microsoft's Wes Miller.
Rather, the documents list only Apple and Google as Windows' primary threats on the desktop.
Of course, embedded Linux is still acknowledged as a problem in that arena -- not to mention servers, of course -- but author Matt Rosoff (formerly with Directions on Microsoft as well, it most certainly should be noted) comes to a very happy conclusion anyway: "So much for all those predictions that Linux would kill Windows," he writes.
Awww, isn't that nice? We really *are* friends now!
'MS Is Very Afraid of Linux'
Then again, maybe not.
"The actions 'speak' louder than the words," wrote SAL-e in the comments on Business Insider.
"Microsoft is acting like patent troll and filing law-suits left and right," SAL-e explained. "MS is very afraid of Linux, especially in the mobile arena."
Similar sentiments could be heard down at the blogosphere's Broken Windows Lounge.
"They only downgraded Linux as a threat on the desktop, so the underhanded FUD and legal attacks are likely to continue," consultant and Slashdot blogger Gerhard Mack told Linux Girl.
'The Reality Distortion Field'
Indeed, "the last time I looked, the threats Google represents to both Microsoft and Apple all carried 'Powered by Linux' stickers," noted Barbara Hudson, a blogger on Slashdot who goes by "Tom" on the site.
"Those tablets and smartphones and web-based apps and ChromeOS laptops with their Google DNA and Linux underpinnings are all direct threats to the Windows OS, so I wouldn't say this is a downgrading of Linux, but an acceptance that Google is going to be the primary way that most people will adopt Linux without realizing it," Hudson explained.
"Of course, it would take a Microsoftie to tweet that this means 'Linux isn't a threat to the Windows desktop any longer,' she added, quoting Miller's words. "This proves two things: Apple and Steve Jobs don't have a monopoly on the Reality Distortion Field, and Twitter -- with its 140-character limit -- is never going to be the source of any serious analysis."
'Threat Level Is Red'
Linux is "not an operating system but a component of many operating systems, all of which are taking a slice of M$'s pie: GNU/Linux, Android/Linux, Meego and WebOS," agreed blogger Robert Pogson. "Whereas M$ used to have weak competition from GNU/Linux and MacOS, they are now surrounded and holed at the water-line."
Microsoft is "still dishonest," Pogson added. "A 'PC' is a personal computer and not necessarily one with M$'s OS. There is not much indication that demand for PCs will reduce, but PCs running M$'s OS certainly are being replaced with more functional units at lower prices.
"M$, after decades, is now having to compete on price/performance," he concluded.
Bottom line? "Threat level is Red," Pogson added.
'The Year the Desktop All But Goes Away'
Hyperlogos blogger Martin Espinoza took a similar view.
"It looks like there won't be any year of the Linux desktop, mostly because it's going to be the year the desktop all but goes away," Espinoza told Linux Girl.
"Pundits have long predicted the virtual disappearance of the computer as we know it, and the broad acceptance of powerful smartphones seems to be putting the truth to that once seemingly ridiculous proclamation," he added.
'Filled to the Brim with Zealots'
Slashdot blogger and Windows fan hairyfeet saw it differently.
In fact, Linux really isn't a threat to Microsoft, hairyfeet told Linux Girl.
"For little shops like mine it would be really nice if it was, but it really isn't," hairyfeet said.
Linux also hasn't improved in the past two years, he added: "Drivers are just as buggy, upgrades still kill hardware, waaaay too many things are tied to what kernel version you have, and the whole thing is filled to the brim with zealots that act like you kicked a puppy if you dare to point out what is wrong.
"It has been 20 years since Linus released the Linux kernel, and it still hasn't gotten above the margin of error," he concluded. "Why? Simple -- Linux is BY geeks and FOR geeks, and not a single one with any power will listen to the users."
'Linux Will Continue to Make Inroads'
Chris Travers, a Slashdot blogger who works on the LedgerSMB project, wasn't convinced that Microsoft's changed wording had much significance.
"It does represent a developing understanding that Windows is deeply entrenched in some markets and Linux as a general operating system is not really able to unseat it at the present moment," Travers said. "I think that Linux will continue to make inroads into these areas slowly, however."
In the long run, though, the real threats to Microsoft and Windows may have nothing to do with operating systems, Hudson suggested.
'The Tech Elephant Graveyard'
"It's become an ingrained truth that Microsoft cannot take the initiative; its actions are knee-jerk responses to products and services from Apple and Google," she explained.
"Nobody believes that Microsoft is capable of planning and executing anything really new and innovative, or even buying successful technology and integrating it," Hudson added. "Rather, it is the tech Elephant Graveyard, the place where other companies (Danger, Nokia, etc.) go to die.
"Of course, a more up-front appraisal would have listed Microsoft CEO Steve Ballmer as the biggest threat to Microsoft," she added. "But that's a whole other story."


text:
|There are 6 sections of this class
|3 years to under 6 years
|Potential Fees:
Swimming Instruction Fees Fees: $40.00 (Required)
Applicable discounts not applied and Taxes included in price.
The objectives of Level 2 are to further develop basic aquatic skills. Children begin to perform these skills at a slightly more advanced level (for example, for longer lengths of time, for longer distances or in deeper water). Many skills in Level 1 are performed with assistance. Level 2 marks the beginning of independent aquatic locomotion skills. Children continue to explore using simultaneous and alternating arm and leg actions on the front and back to gain greater proficiency in preparation for performing strokes. Level 2 also builds on the water safety topics introduced in Level 1.
Pre-School and Waterbaby classes are 30 minutes in duration. All other classes are 45 minutes in duration.
Each session is Monday-Friday for two (2) weeks.
No refund will be issued without receipt.
Refunds are given with a fee of 10% or $10, whichever is greater, for any cancellation.
You may apply any refund amount as a credit towards another Parks & Recreation or Aquatics Program.
If you have any questions please contact the Bryan Aquatic Center at (979)209-5222.
For more information on the specific skills taught in the class you've selected please see the attached receipt documents.
|Receipt Document(s):
|view Receipt Document(s) for this item.


text:
10 Foot Pro Audio Banana to Speakon Speaker Cable
10 Foot Pro Audio Banana to Speakon Speaker Cable
Order By Phone
Free Same Day Shipping
Product Code: B12SP10
We realize that you want your Pro Audio Equipment yesterday. Here at Seismic Audio Speakers, we aim to ship items out immediately. If you place your order before 2:30 Central time, we will ship your pro audio equipment on the very same business day.
Enter Zipcode
Order today, and you'll receive your package on *.


text:
Regenaskin Hyaluronic Cream
RegenaLife Price: $49.99
Your 1st Order - Buy Now!
Use Code: rskin50 at checkout
Regenaskin Hyaluronic Cream
Lightweight yet ultra-hydrating, Hyaluronic Cream absorbs quickly, infusing the skin with a multi-layered moisture system. A creamy emulsification of hyaluronic acid, squalane, jojoba seed oil, and apricot kernel oil, this formula has the unique ability to cater to skin's individual hydration needs.
Skin is only capable of holding so much moisture. As a hydrophilic, or water-attracting molecule, hyaluronic acid ensures that skin receives the perfect amount of hydration. When applied, this formula immediately sinks in, improving the appearance of fine lines and increasing suppleness.
Why is it different?
1. Smart Hydration: Capable of holding up to 1000 times its own weight in water, hyaluronic acid soaks in easily to instantaneously recharge moisture levels and restore skin's suppleness. In addition, hyaluronic acid is a hydrophilic humectant that continuously draws water from the air, thereby steadily replenishing hydration over time.
2. Multi-Level Moisture: In addition to the superior hydrating benefits of hyaluronic acid and squalane, this formula includes two lightweight oils, jojoba seed oil and apricot kernel oil, that quickly absorb to soften and plump. These ingredients work synergistically to provide multiple layers of moisture that stay locked in for lasting hydration.
Key Benefits- Provides multi-layered moisture
- Improves the appearance of fine lines
- Absorbs quickly
- Absorbs quickly
- Plumps skin's appearance
How it works
Well-balanced formulations are essential for helping skin maintain optimum levels of hydration. The most effective moisturizers contain an emulsion of ingredients that work synergistically to build levels of moisture from the inside out. A humectant, like hyaluronic acid, is a water-based ingredient that draws moisture from its environment to the surface of the skin. By nature, their job is to increase the water content of the skin. Emollients, such as squalane and jojoba seed oil, nourish and condition the skin, providing extra moisture as they soften, while occlusives are ingredients that form micro-seal on skin's surface, ensuring that moisture stays locked in for lasting hydration. Some ingredients, such as apricot kernel oil, have both emollient and occlusive properties.
Key Ingredients
Hyaluronic Acid (Sodium Hyaluronate): Known for its ability to hold up to 1,000 times its weight in water, Hyaluronic Acid is a humectant that draws moisture into the skin.
Squalane: Derived from olives, squalane works to deeply moisturize. It is biologically close to skin's own sebum, which makes it an excellent emollient.
Jojoba Seed Oil (Simmondsia Chinensis Seed Oil): Derived from a perennial shrub native to the southwestern US and parts of Mexico, jojoba seed oil is rich in fatty acids, and acts as a lightweight emollient.
Apricot Kernel Oil (Prunus Armeniaca Kernel Oil): Made from the seeds of apricots, apricot kernel oil is a light yet effective moisturizer, that works well with all skin types to deliver hydration.
Hyaluronic Cream Ingredients: Hyaluronic Acid (Sodium Hyaluronate), Squalane, Jojoba Seed Oil (Simmondsia Chinensis Seed Oil), Apricot Kernel Oil (Prunus Armeniaca Kernel Oil)
Hyaluronic Cream Usagee: Apply to Face & Neck 2 times per day.
Hyaluronic Cream Facts: No Parabens or Phthalates


text:
I can't stop thinking about how Marlene King told me someone is going to get tortured in "A"'s lair during the season finale and how even the production team was crying over it when they were filming. I'm leaning toward it being Spencer or Hanna because Season 2 has been Emily's own personal hellscape and what's "A" going to do to Aria? Stop the weather so she can't make out with Ezbian's face in it anymore?
But that's only a fraction of the things we've got to think about right now. We're going to solve the mystery of "A" in three weeks. Some beloved character is going to die. At least one Liar is coming face-to-face with a murder room. Plus, Maya has either run away or been kidnapped or Noel Kahn spotted her at the bus station and made that one creepy-ass Joker face he makes and she was sucked into his smile like a black hole. But Shay Mitchell did say we haven't seen the last of Maya, which means she must be coming back at some point in the next three episodes. And Lindsey Shaw is slated for the finale, and she hinted that she'd be back for the third season to deal with some unfinished business. But mostly I cannot stop thinking about the majesty of Troian Bellisario's shoulders, which were on full display in a variety of ways this week and, 12 hours later, I still feel like I've been hit with a Confundus Charm.
Anyway, so Emily has been downtown to the police station again to account for the whereabouts of another missing lady love. Hanna is waiting up on her, all, "How was it? Did they make you fill out another one of those How Did You Kill Girlfriend forms?" Emily doesn't feel like chatting about it, if you want to know the truth. She just wrangled her way back onto the swim team after being found in the presence of a shovel; what kind of blackmail will get her spot back now that she's the leading suspect in the case of another disappearing student? Ten years from now Rosewood kids will be telling the tale of how gay ladies kept moving into this one bedroom at the old DiLaurentis place and Emily Fields, hopped up on Human Growth Hormone, kept murdering them in their sleep. But for now Maya isn't returning any of Emily's texts or calls, so probably they're broken up, thanks a lot marijuana.
Spencer and Melissa are camped out in a car in a deserted alleyway in the dark at the witching hour so as not to be overheard by their conniving parents. Spencer's like, "Just so we're clear, you bailed on me to take a ride around town with Garrett" — whom, just parenthetically, Melissa is calling "The Police" — "and tell him every single thing about my own personal business." Melissa goes, "That is correct. I told him everything about where you sleep, what times of the day you're in the house alone, where you keep the videos of us murdering Alison, how the jig is almost up. But I needed a friend, OK? After Ian tried to murder my own sister, I was like, 'No way did Ian murder my sister's best friend.' Because, honestly, I think mom and dad killed Alison." Spencer pulls out her iPhone, opens up the Scooby Dooby App, and moves Melissa right the f–k up to the top of her list of "A" suspects. Finally. Lord.
Morning at the Montgomerys. Aria has fashioned together an outfit she calls All The Patterns. Ella pops her head in the door: "Your dad is directing this episode called 'Father Knows Best,' which is the most ironic thing, right?" Aria is like, "Because of how no father on earth knows less best than Byron Montgomery?" They giggle about what a toolbox he is, but then Ella goes, "Seriously, though. That father/daughter dance is tonight, so pick out some ungodly thing to wear and your dad will be here at 7:00."
Detective Snape rings up Ashley first thing in the morning and she literally goes, "I told you never to call me here!" Ashley Marin is the greatest, you guys. Back when she was robbing the elderly and murdering architects, I don't think I fully realized how wonderful she is. But she is just the best thing. Snape goes, "I want to talk about that police report some more." And she's all, "I want to talk about how if you call me at this number one more time I will chop you into pieces and stuff you into pasta boxes … lol, OK, see you later, Ella!" Because Hanna comes be-bopping into the kitchen. Her horrible father won't be taking her to the father/daughter dance, which upsets her for inexplicable reasons.
Ashley goes, "Since we have established that I am better than all the parents on this show/the earth, I will happily escort you to the dance, my dear." Hanna doesn't want to go to the dance with her mom. But Ashley doesn't feel too bad about it on account of every lesbian watching this program shouting, "I'LL GO TO THE DANCE WITH YOU, ASHLEY" in unison.


text:
Allan Grant necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 154 diseños de 34 diseñadores freelance.
Be Great Organization
Be Great Organization is a new membership-based organization built around Peter H. Thomas's new book, titled "Be Great". See the cover of it here:
See the logo of it and a photo of Peter H. Thomas:
Peter H. Thomas is a world-reknown business leader who built Century 21 Canada, completed multi-billion dollar real estate transactions, and continues to live an adventurous life while following his values. His new book teaches how to follow your values and achieve greatness in whatever may be your life purpose.
Be Great Organization is being formed to help people and other organizations develop their greatness. It is primarily an organization for entrepreneurs and businesspeople, but also for charity organizations and college students aspiring to become businesspeople.
BONUS AWARD: A signed copy of Be Great Book addressed to YOU by Peter H. Thomas, a best selling author. Be Great is the #1 best selling book in Canada, and has not yet launched in US.
Entrepreneurs, businesspeople of all ages, charity organizations. Anyone interested in improving themselves and living life to the fullest.
The logo must say "Be Great Organization". It may optionally also have a symbol. The symbol may optionally read "BGO" or may be a vector graphic.
A logo that looks good on the web (primary place where it will be used) as well as on paper.
Although not a requirement, we would prefer a logo that stays consistent with the color and design style of the logo of the book (the words Be Great in red and black serif letters -- as seen on the website). Generally the colors red, white, and black are probably among the best.
Also not a requirements, but a preference: Be Great should be bigger / more prominent than the word "Organization".
Bonus: a logo symbol for BGO. Ideally this would be a stylized vector graphic, and not just text.
BONUS AWARD: A signed copy of Be Great Book addressed to YOU by Peter H. Thomas, a best selling author. Be Great is the #1 best selling book in Canada, and has not yet launched in US.
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


text:
Summer annual pastures can provide valuable, high-quality forage during a season when your permanent pastures may be running out of gas. Almost all parts of the U.S. can add warm-season annuals as a part of their forage program. Forage crops, ranging from corn to crabgrass, fit in the summer annual category. Most cattlemen are more familiar with sudangrass, sorghum-sudan hybrids and millets as summer pasture crops.
Using cornstalk fields for wintering dry cows is a common practice, but using green, standing corn as a forage crop is a relatively new concept in the U.S.
Crabgrass may be a weed to crop farmers and hay producers, but it's a very valuable annual forage for cattlemen. Knowing where, when, and how to use these crops is the key to success.
All annual pastures, except crabgrass, are relatively expensive to establish. Thus, you need a high-value product or very efficient use to afford them. As finishing cattle on pasture and running stockers typically generate a higher net return, these are enterprises where summer annuals may be particularly valuable. Meanwhile, cow-calf operations typically experience lower returns, so summer annual use may be harder to justify.
If the annual pasture extends your grazing season and allows you to feed less hay in the dry summer or winter months, and as long as the cost per day for the annual pasture is lower than the cost of hay, it's a viable alternative.
Capturing a better return
Controlled grazing will help you capture a better return on your investment through high grazing efficiency compared to set stocking. If you're going to spend money to establish and grow annual pasture, spend a little more to manage it more effectively.
I've seen pasture yields on summer annuals as low as 50-70 AUD/acre to more than 400 AUD/acre. Some of the difference is due to additional irrigation or fertilizer, but much of it is attributable to inefficient grazing when the summer annual gets head high.
One big challenge of using summer annual pasture is its explosive growth potential in hot weather. If there's moisture, warm-season annuals can grow at astounding rates. The crop can get away from you literally overnight.
Most annuals can support much higher stocking rates than perennial pastures, so be prepared to go to the pasture with a lot of animals. Keeping the pasture under control takes aggressive management. Once warm-season annuals get taller than the animals, grazing efficiency drops significantly.
One of the first concerns for many cattlemen is the risk of prussic acid (PA) poisoning from annual pastures. Prussic acid is a precursor to cyanide and can be deadly.
Only the grasses in the sorghum family contain this toxin. Corn, millets, and crabgrass are PA-free. A low-level PA is almost always present in the sorghum family but doesn't become a problem until the plant is stressed. Drought, frost, disease or herbicide injury can lead to toxicity. Avoiding its use during stress conditions is the best preventive management.
Early in the growth stage of most sorghum crops, PA is naturally high, so don't begin grazing them until they reach a safe level. As a general rule, avoid grazing sorghums or sudan grass until they reach at least 15-18 in. height. We've all heard the neighbor's story about how he started grazing such crops at 12 in. without a problem. That's lucky for him, but don't count on the same experience.
Don't overlook crabgrass
Crabgrass is an often-overlooked forage crop. It's native in many pastures in the South and into the Midwest.
In Missouri, we found many tall fescue-dominant pastures naturally turned to crabgrass during summer months when fescue became less competitive. As much as a quarter of our annual production might come from naturally occurring crabgrass.
A few management changes can really encourage crabgrass. A shot of nitrogen in early June will stimulate the crabgrass as the fescue is fading and help summer pasture production. Resting the pasture in September to let the crabgrass set seed will ensure next year's crop. It's the lowest cost summer annual pasture available in the fescue belt.
Jim Gerrish is a grazing management consultant based in May, ID, and former lead pasture researcher at the University of Missouri's Forage Systems Research Center in Linneus. Reach him at 208/876-4067, email@example.com, or visit http://americangrazinglands.com.


text:
When Enovid, the first birth control pill approved by the U.S. Food and Drug Administration, hit the market in 1960, American women were eager for the option. Previously cleared as a treatment for menstrual disorders in 1957, Enovid was already making the rounds among gynecological practices, with half a million prescriptions doled out ostensibly to regulate periods [source: PBS]. When the pill turned 40 in 2010, an estimated 100 million women around the world were using oral contraceptives, primarily to prevent pregnancies [source: TIME].
Birth control pills prevent pregnancy by inhibiting a woman's ovaries from releasing a mature egg into the fallopian tubes during monthly ovulation [source: Planned Parenthood]. Typically, oral contraceptives combine the hormones estrogen and progestin to maintain a routine menstrual cycle, sans ovulation. In doing so, birth control has granted women greater agency over their bodies and their reproductive systems, allowing them to better manage if and when motherhood happens. As a side effect of reducing the pregnancy risk, the pill also opened the door to greater sexual freedom.
But eliminating ovulation may also affect women's sex lives in more subtle ways, recent studies are starting to show. In the process of tricking a female body into thinking it's pregnant, oral contraceptives may discretely alter heterosexual women's attraction to men and vice versa. Although none of the following five birth control-related reactions pose any direct risk to women, they're fascinating examples of how a single, tiny egg can make a monthly difference.


text: Eyes in the wall Posted by Sebastian Schenker on Monday, March 27. 2017 Trackbacks Trackback specific URI for this entry No Trackbacks Comments Display comments as Linear | Threaded No comments Add Comment Name Email Homepage Comment In reply to [ Top level ] Phone* What is one plus nine? Standard emoticons like :-) and ;-) are converted to images.You can use [geshi lang=lang_name [,ln={y|n}]][/geshi] tags to embed source code snippets.Markdown format allowed Form options Remember Information? Subscribe to this entry


text:
Justin Haywood Joins ODU Staff
By ODU Athletics
Sept. 10, 2010
NORFOLK,VA -Old Dominion University head baseball coach Nate Goulet name Justin Haywood volunteer assistant coach. Haywood is a 2005 graduate of nearby Hickory High School.
"We are thrilled to have Justin join our coaching staff. He will work primarily with the catchers and Outfielders and assist with our hitters. Coming from the University of Louisville he brings a wealth Of knowledge, enthusiasm, and passion for the game of baseball. He will be a great addition to our program." - ODU head coach Nate Goulet.
Haywood performed duties as assistant administrator for the 2009 USA Collegiate Baseball team. as a collegian, Haywood played for the University of Louisville who won two BIGEAST Tournament Championships, made four NCAA regional appearances, two Super Regional Appearances and the 2007 College World Series. Twice Haywood was named to the AD Honor Roll and BIGEAST Academic All-Star.
At Hickory, Haywood played in the 2004 Big League World Series for US South as they placed fifth. He was also captain on the Hickory High basketball team as a senior.
Haywood graduated with a B.S. degree in sport management from the University of Louisville.