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Liberal activist and actor Warren Beatty was the guest speaker, but the celebrities of the night were sitting in a table just down from the podium.
It was the annual "Rage for Justice" dinner at the Beverly Hills Hotel sponsored by the Foundation for Taxpayers and Consumer Rights (now called "Consumer Watch"). The crowd of trial layers, Democratic party activists and others were celebrating the defeat of all five of Gov. Arnold Schwarzenegger's ballot measures in the 2005 special election.
The toast of the night went to those at that for mentioned table. They were members of the California Nurses Association. The union had harassed Schwarzenegger throughout the campaign as they would do years later with Meg Whitman.
U.S. & World
"They are incredible," one of the dinner organizers told me with great enthusiasm. "Do you know how well they research? Nurses have the highest approval and credibility rating of any single occupation. It is incredible."
The CNA never attempted to take over the capitol building in Sacramento. That, right now, is the goal of a another union. And it raises the question of how differently members of these two unions are perceived by the public. The California Teachers Association is one of the largest unions in the nation.
Ask any lawmaker in Sacramento and they will tell you (off the record) that for years there was not one piece of legislation that passed both the state Assembly and state Senate without CTA approval. That has changed slightly because of pressure from low income communities that have felt the brunt of union regulations such as the "last hired first fired" tenure policy.
Such an incremental slip isn't the only issue for the CTA leadership as the union protests budget cuts this week. "Waiting for Superman", the documentary from the same producer who put together Al Gore's "Inconvenient Truth" didn't help. Neither does the recent news that the state commission that handles teacher credentialing often waited years before pulling the license of teachers accused of misconduct with students.
And, while schools are populated with dedicated instructors who undoubtedly do deserve a raise, there is ample evidence that there are plenty who don't. The public is starting to learn (or experience) the "dance of the lemons" routine that principals go through every year. Since you can't fire an incompetent teacher you simply try to get them to move to another school.
Union leaders normally talk less about their members than they do the "students they teach". But even teachers I've talked to fear that is now being seen as a marketing pitch rather than reality. This is the teachers union after all.
As Albert Shanker, the late head of the United Federation of Teachers once put it, "When schoolchildren start paying union dues, that's when I'll start representing the interests of schoolchildren."
The fight in Sacramento is currently over the budget but it also involves the court of public opinion. The CTA needs to win that fight but it may take more than a rotunda sit-in.


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When the third annual Summer Hummer hits the Signature Theatre stage on Monday night, history will be made – again. The burlesque-style fundraiser showcases Washington's top talent in a forum like no other. From the iconic striptease to rowdy production numbers and deliciously off-color patter, each Hummer is a legend in its own right.
Eric Schaeffer, co-director of the evening with Matt Gardiner, remembers, "The performance of 'Miss Pussy Foot' last year had us all laughing so much we were crying." Delivered by Sherri L. Edelen in a leopard-print leotard, the song hails from the light-hearted Goldilocks, a short-lived Broadway vehicle for Elaine Stritch, circa 1958. In Edelen's paws, lines like "There is no other pussy like I, strutting down the alley," took on a whole new meaning. "There's nothing better than hearing a song about someone's pussy," Schaeffer insists, before correcting himself. "I mean 'cat.'"
Oddly, animals also play a role in the memories of Tracy Olivera, a Hummer veteran. "My favorite moment from the first Summer Hummer was definitely bringing my dog Beesley on stage," she says. "When she got up there, she sat right on cue. She hasn't done that before or since." The number was Sondheim's "I Never Do Anything Twice," performed by Donna Miglicaccio.
"The first verse hints at the narrator experiencing a three-way with a handsome captain and a husky St. Bernard," Migliaccio explains. "Evan Casey [Olivera's husband] led Beasley on for that verse and they both stood obediently until the verse was over, then exited left. The final chorus is the narrator reaffirming that she never does anything twice, no matter how pleasurable, 'except....' At that point Tracy led Beasley back on. I eyeballed Beasley lingeringly, then sang 'No, I never do anything twice' and kissed Tracy. It made a great button for the song, and of course, Beasley was cool as a cucumber about the whole thing, just like her parents."
For Casey, the drama backstage is almost as good as what's happening out front. "It's the best kind of organized chaos," he says, "with people running, prepping, and rehearsing for their next number or costume change, be it in a negligée, a jockstrap, or in drag. If you're not preparing for the next number, you're often watching from the wings, taking in the hilarity and debauchery. It's basically what you're always hoping the Helen Hayes after party will devolve into."
Happily, the riotous atmosphere is contagious. "I think the audience feeds off that backstage energy," Casey says. "There's hooting, cheering, and laughter the likes of which could only occur on a night like that. I also think the fact that it's being done for Taking Care of Our Own brings with it a special sense of pride and community spirit. Not only are we all treated to a one-night-only showcase of DC's finest talent at their most irreverent and revealing, but we're doing it all to support the wonderful artists that make this such a vibrant theatre community."
theatreWashington's Taking Care of Our Own fund provides emergency assistance to members of the theatre community who find themselves in sudden need. To date, more than $100,000 has been raised through a combination of Summer Hummer proceeds, individual donations, and the Bucket Brigade, which gathers donations following performances at a rotating series of area theatres. Carefully administered through an application process that is both swift and discerning, the fund has distributed more than $16,000.
Casey has high hopes for this year's Hummer. "What I look forward to the most is seeing the créme de la créme of DC theatre let their hair down and truly be silly for an evening," he says. "So often we only know these actors by the roles they tackle, be it interpreting Shakespeare or Sondheim. To see them step 'out of character,' as it were, and really let loose is a real treat."
Olivera adds, "I think people like to participate in the Hummer because it gives us a chance to do things on stage that we don't normally do – even if it's just dropping four letter words. This community is so supportive of one another though, and has a blast doing it." Schaeffer agrees, "It's such a good cause and we've helped so many friends in our theatrical family over the past year. And it's just a fun night where everyone gets to be a bit raunchy."
Click here to purchase tickets for Summer Hummer: Menage a Trois, at Signature Theatre, 8pm, Monday, August 18, 2014.

subset: commoncrawl


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Two lose office in tribal primary
Last updated 5/15/2013 at 8:29am
Two Colville Business Council incumbents lost out in their bids for another term in the primary election certified last week.
Losing in the primary were Brian Nissen, in position 1 in the Nespelem District and Darlene Zacherlie in the position 1 race in the Keller District.
Nissen came in third in the vote tally with 112 votes, trailing Deb Louie (155) and Ricky Gabriel (117). Louie and Gabriel will face off in the June 15 general election.
Others in that race and their votes were Randy Laramie (43), Joaquin Marchand (89) and Tum-chis-li-wit Mylan Williams, Sr. (16).
In the Keller District position 1 race, where Zacherie got ousted, Jack W. Ferguson with 52 votes will face John F. Stensgar (48) in the general election. Incumbent Zacherlie received 46 votes. Others running and their vote totals were Leroy Jerred (6) and Sylvia Tatshama Peasley (18).
Stevey Seymour, with 87 votes, and David T. Madera (83) run against each other in the Inchelium position 1 race. Doug Seymour received 68 votes. There was no incumbent running.
In the Omak District position 1 race, incumbent Ernest "Sneena" Brooks topped the vote count with 149 and will face off in the general election against challenger Shirley K. Charley who had 113 votes. Others in that race were Karen Condon (52), Stuart Sellars (44) and Ricard Tupling (107).
In Nespelem District position 2, incumbent Andrew C. Joseph, Jr., overwhelmed the field with 213 votes and will face Enid T. Wipple who garnered 103 votes. Others in the race were Charlene Bearcub (101), Jonnie L. Bray (57) and John St. Pierre (59).
In Omak District position 2, incumbent Benny Marchand Jr., who was second in the vote count with 183 votes, will face off against Michael E. Marchand who had 197 votes. Others in that race were Anne "Muffin" Marchand (50) and Luana L. Squetimkin (38).
There was no primary election for position 2 in the Inchelium District.
The Colville Tribal Business Council is made up of 14 members, with seven up for election each year.


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Restoration partners share progress, reinvigorate work, build relationships
Stewardship Fund grant recipients came together at an annual forum.
by Catherine Krikstan
March 13, 2013
Fencing off a stream from livestock, planting trees along a soon-to-be-shaded river or creating marshland to provide habitat to fish, frogs and birds: restoration projects such as these would not be possible without the hundreds of watershed groups working across the Chesapeake Bay region, or the networking needed to connect restoration partners with their peers.
Each year, the National Fish and Wildlife Foundation (NFWF)—which supports Bay restoration with grants offered through the Chesapeake Bay Stewardship Fund—gives restoration partners a break from their intensive on-the-ground work with the Chesapeake Bay Agricultural Networking Forum. Last week, this forum brought more than 100 grantees together in Staunton, Va., to discuss restoration successes, challenges and solutions to common problems, networking with each other and forming invaluable partnerships.
"Our grantees really are the front lines of the Bay restoration effort," said Amanda Bassow, NFWF Director of Chesapeake Programs. "We need to arm them with all the knowledge, resources and experience we can. These are the people who are accelerating progress, engaging new partners and new landowners, and continually figuring out new ways to get the job done."
The forum began with a rapid-fire update from grantees working on close to a dozen projects, ranging from forest buffer plantings to the engagement of so-called "absentee landowners"—or those landowners who do not work their own farmland—in conservation. Field trips in and around Staunton gave participants a hands-on look at areas in which progress is underway. On the Merrifield and Ford farms, for instance, located in the Poague Run watershed, landowners have restored stream banks, protected streamside forests and excluded livestock from sensitive waterways.
"Grantees tell me they love the forum because they get re-energized about their work," Bassow said. "It's a community of doers, not finger pointers, and when you get them all in a room together, it's a powerful thing to see."
Chesapeake Bay Program Director Nick DiPasquale moderated a session at the forum, and found the event to be a meaningful one.
"For farmers and farm service providers, conservation district staff, government officials, funders and non-governmental organizations, this was a great exchange of ideas and approaches on implementing effective and innovative agricultural best management practices," DiPasquale said. "This forum should help the community save money, clean up local waterways and keep farmers farming while using creative ways to manage nutrients on their land."
Read more about the NFWF and the Chesapeake Bay Stewardship Fund.


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Steve Zipperstein, Verizon's vice president for legal and external affairs, has called on the FCC to hand over the D Block of spectrum to public safety bodies instead of trying to auction it off again.
The plan, which emerged from a speech given to the National Press Club in Washington, as reported by PolicyTracker, calls for local public-safety organisations to be allocated radio spectrum without charge, to use as they see fit.
The spectrum, which falls towards the middle of 700MHz, was unsuccessfully put on the auction block 12 months ago, at which time it emerged that no-one was prepared to pay $1.3bn for spectrum they'd have to share with the emergency services. The current plan is to auction it off again, with a more-modest reserve of $750m, but Mr. Zipperstein thinks it should be handed over to public safety bodies for their exclusive use.
The idea would be that local public-safety bodies would be able to use the spectrum, managed by local authorities, and be at liberty to deploy technologies purchased from any company they like: "Direct assignment of all of the spectrum to state and local public safety entities will enable them to have greater control over network design and day-to-day operation", as Mr. Zipperstein put it.
But the choice of technology will be decided nationally: "letting them develop independently without any guiding national principles would simply repeat the mistakes of the past", so Mr. Zipperstein goes on to explain that an IP-based technology would ensure interoperability, and that the cost of deployment could be met through long-term contracts (like the UK's Airwave System, that O2 paid to build).
The original, and current, plan is to have the buyer of the D Block build the infrastructure and then provide the emergency services with priority access to it, but since that plan was created we have a new head commissioner on the FCC, who will almost certainly want to revisit the plan so things could easily shift in Verizon's proposed direction.
That would mean no competitor picking up some cheap 700MHz spectrum, and could provide a large number of smaller contracts, but it could also mean America gets the public-safety network it needs without trying to flog spectrum no-one seems to want. ®
Sponsored: Webcast: Ransomware has gone nuclear


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Cornerstone has the right products and professional advice to help you plan for major milestones-like college education and retirement-and everything in between. Plan now for a smoother ride in the future.
(You'll be redirected to a third-party site.)
Into each life some rain must fall. At Cornerstone, you are covered with life, health and property insurance products at competitive rates.
It's as easy as point, click and learn. Find everything from online articles on financial topics to credit counseling and financial seminars, all free for Cornerstone members.


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My idea of a romantic comedy!
Last night I had the pleasure of introducing the boyfriend to the 1971 film Harold & Maude. How he managed to make it to age thirtysomething without ever seeing it sooner shows an utter lack of regard from his friends and family, and we can only praise Allah that I showed up in his life.
Oddly enough, we seem devoted to cinema circa '71 this week, as the films featured in our fetching living room all hail from that year. Before Harold & Maude was The Andromeda Strain, a movie which may well be the most boring sci-fi thriller ever to be shot, but was so beautiful we couldn't stop looking. Oh, so boring! Imagine the longest, highest budget, fantastically designed instructional video ever, or if Stanley Kubrick had decided to make 2001: A Space Odyssey without all that pesky meaning.
Before that was Ciao! Manhattan, the enigmatic art film that accidentally became a biographical piece on tragic, subculture superstar, Edie Sedgwick. I hesitate to comment further on this particular work, because it presently consumes me in my career and I'm sure I'll be devoting an entire blog to it someday soon. But if you're a fan of all-things-touching Warhol's Factory, the film is a must-see. Or if you just want to see a lot of full frontal nudity from a former Vogue model who'd recently gotten a boob job, there's that.


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Howdy Rick
I think I may know that intrepid mountaineer
Miles of smiles,
Hiking, Climbing, Camping, Trail Running, Snowshoeing...
Sally wrote:Rick M, I hope that guy applied sunscreen to his ENTIRE body and did not attempt to glissade back down the Bowl!
Ellen wrote:I think I may know that intrepid mountaineer
Rick M wrote:As a reminder to dress warmly with winter just around the corner.
Climber just below Baldy's summit nearing the top of the bowl.
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IHRSA 2000: The Eyes Have It
In addition to building muscles and strengthening hearts, health clubs may one day be in the business of collecting eyeballs.
Fortunately, that's not as gruesome as it sounds. Eyeballs is a buzzword used to describe views of a Web site; the more eyeballs a site gets, the more successful it is as an advertising source.
At IHRSA 2000, eyeballs was a term heard often at booths, conferences and cocktail parties. Partnerships between equipment manufacturers, dot-com companies, entertainment suppliers and/or club chains demonstrated that health club members-who typically occupy an affluent demographic-possess valuable eyeballs. The result was new offerings designed to gather members' attention-and, in some cases, data.
Yes, there was enough on the show floor to satisfy traditionalists. Cybex, Life Fitness and Ground Zero all exhibited equipment that could very well represent the next evolution of strength training. And new bikes from Star Trac, Q Sports and StairMaster (which had the support of Greg LeMond, the first American to win the Tour de France) proved that the group cycling phenomenon is still white-hot. Still, the fact that more than a dozen dot-com companies took up booth space indicated change was in the air. And attendees only had to visit entertainment exhibitors to confirm that our industry was witnessing a revolution, with Internet-enabled technologies at the forefront.
The mood was set early when, on the first day of the show, Netpulse, Life Fitness and Bally Total Fitness held a press conference to announce strategic partnerships. Both Life Fitness and Bally have made equity investments in Netpulse. In addition, the exercise equipment at Bally's fitness centers will be equipped with Netpulse Internet systems. Bally's Web site, www.ballyfitness.com, will receive direct links on the systems, and both Bally and Netpulse will work together to coordinate online advertising promotions and product sampling targeted toward Bally's 4 million members. Again, this exemplifies the industry's interest in getting eyeballs.
The news didn't end there for Netpulse. The company teamed up with Broadcast-Vision (a supplier of wireless entertainment systems) and ClubCom (a provider of music video entertainment and e-commerce capabilities) to deliver Internet, audio, video, programming and revenue options-free for qualified clubs that can deliver the right number of eyeballs.
Meanwhile, FitLinxx, a supplier of interactive fitness systems, announced a partnership with Netpulse that allows members to track Netpulse workouts as part of their personal FitLinxx exercise programs. FitLinxx also launched a program at the show that creates customized Web sites for fitness facilities, a move that earned FitLinxx the title of "Official Web Provider" from IHRSA.
In a nearby booth, E-Zone, a provider of a robust digital entertainment system, was making some virtual waves of its own. It partnered with CardioTheater to enhance its entertainment offerings and with GetFit.com to help users track their workout data. E-Zone also teamed up with manufacturers such as StairMaster and Precor to create one-on-one exercise programs that members can access while using the appropriate cardio equipment. For example, if a member is using the new StairMaster exercise bike equipped with an E-Zone unit, he can select a training video featuring Greg LeMond.
Like Netpulse, E-Zone gives its systems away to qualified clubs. The payback comes from, as you may have already guessed, eyeballs. To use E-Zone, members supply information about themselves, and when they log on to the system, they watch two minutes of demographically assigned advertising. That's how E-Zone expects to earn the lion's share of its revenue. Clubs can also earn some money through the Club TV feature, a customized channel that can include local advertising.
The trade show floor wasn't the only area buzzing with talk of the Internet and eyeballs. During IHRSA's invitation-only global summit meeting, industry leaders discussed the effect technology will have on our industry. One speaker, 24 Hour Fitness's Mark Mastrov, predicted that club memberships would one day be free-because clubs would make money by putting eyeballs in front of entertainment systems that feature advertising. Since Mastrov leads the world's largest club chain, it's impossible to dismiss his vision of the future easily.
On the Show Floor
Need more proof that the Internet made a major impact at IHRSA 2000? Consider some of the other announcements that broke during the show:
* Under a new agreement, Compaq iPAQ Internet devices and Compaq Armada M700 notebook PCs will be preloaded with the FitnessAge software assessment program and Internet access. Ready-to-use Internet connectivity will be provided to fitness professionals by Fitness-Age's ISP partners. Additionally, Compaq's hardware and software applications will be tightly integrated into FitnessAge's suite of devices, including its assessment stations, e-commerce kiosks and laptop products.
* CheckFree announced that the CheckFree E-Bill is now available. This gives club members the option of receiving an electronic bill via the Internet each month, which they can then pay with a point and click of a mouse. With E-Bill, the member sees an actual monthly statement on the computer screen and can review it. The member can decide what bank account to use and can schedule the payment.
* The Cybex Institute, the company's training and education facility, will provide fitness content to FitCare.com. The institute will also offer an advanced personal training certification program online on a platform created by FitCare.com.


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Give An IRN Room Makeover As A Wedding, Birthday or Graduation Gift!
Welcome to the Interior Redecorators Network™ (IRN)
Mission Statement:
Our mission is to provide affordable, professional, quality decorating help to the public. Interior Redecorators involve, inform and inspire their clients by helping them make the best of what they have to create more comfortable, attractive and functional living spaces.
Celebrating our 23rd year!
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Whether your space is overcrowded or in need of new furnishings, we can completely redesign a room in a couple of hours, or your entire place in a day.
You'll get a detailed plan for each room. Then, using the exclusive Use What You Have® system, we'll suggest paint colors, rearrange furniture, bring in furnishings from other rooms or, if needed, recommend new pieces to give you a brilliant new look — all for a low flat per-room fee.
Moving to a new house or apartment?
Get a comprehensive yet easy-to-implement decorating guide for your new place — before you move. Let an IRN professional show you which furnishings to take, what may need to be bought, and where to put everything. With a detailed plan in place you'll feel more relaxed, plus save time and money with movers.
If you've already moved into your new space, we can help you make the most of existing pieces, and give you a plan that can be implemented as you have the time and money.
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Whatever you envision, your IRN redecorator is dedicated to involving, informing and inspiring you — and transforming your place into a beautiful, comfortable and more functional place you'll be proud to call home.
Learn More About IRN Signature Services


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Student Tools:
Test Practice
Interactive Vocabulary
Teacher Resources:
Guide to Language Network ClassZone
Power Presentation Answer Key
Professional Development Articles
Online Lesson Planner
From finding reliable Web sites to decoding the messages behind persuasive ads, Language Network ClassZone will help you navigate through the information age. Need help with public speaking or test-taking? Explore the essential links found here. Want hands-on experience? Analyze media messages and produce your own ads with the media literacy activities below. For more on becoming Web-savvy, visit the Web Research Guide.
Chapter Resources:
Key Concepts
Grammar Links
Writing Links
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Test Preparation Links
Speaking and Listening Links
ANALYZING MEDIA: Movie Reviews
ANALYZING AND PRODUCING MEDIA: TV Commercials Past and Present
ANALYZING AND PRODUCING MEDIA: Letter to the EditorVirtual News
Copyright © 1995-2008 Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Art and Photography Credits, Terms and Conditions of Use and Privacy Policy


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Financial Aid
You should apply for aid every year, even if you think you don't qualify. There are many factors affecting eligibility for financial aid, like a change in family financial circumstances. For example, a student who didn't qualify one year might become eligible during the next year when a brother or sister enrolls in college.
To apply for student financial aid from the federal government, including the Pell Grant, Perkins Loan, Stafford Loan and work-study, you will need to submit financial aid applications, the most important of which is the Free Application for Federal Student Aid (FAFSA). Before you fill out the FAFSA, it's imperative that you get to know the form a little better. In doing so, you may be able to qualify for more financial aid, helping you further along the path of going to college.
If you want to get an early estimate of what the government thinks you can afford to pay for your education, try FinAid's Financial Aid Estimation Form. It lets you play what-if games to give you an idea how changes in income and assets affect the expected family contribution (EFC). FinAid also has a variety of other EFC calculators such as the QuickEFC calculator which provides an approximation of the EFC with one tenth the questions.
|Home | Loans | Scholarships | Savings | Military Aid | Other Types of Aid | Financial Aid Applications
Answering Your Questions | Calculators | Beyond Financial Aid | Site Map | About FinAid®
|Copyright © 2020 Fastweb LLC. All rights reserved.
Mark Kantrowitz, Founder


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On Music
Crawling Out of the CribsBy Noah Wunsch
Heading to the Cribs show at Santos Party House, I could feel my brain wired like a motherboard. I was coming off of a two-week caffeine withdrawal, freshly rejuvenated by two black coffees. My fingers danced with anxiety as uncontrolled memories popped into my head. I thought about my camp counselor, Jared, who slap-boxed the kids in our cabin. If one started to cry, he'd play his usual trick: forced flatulence. He'd curl up on the floor like Grotowski's cat, red faced, concentration veining out of his forehead, sucking in air, ass cheeks flexing until he let it rip. Inevitably, the kid would stop crying and Jared would slap-box another camper.
I thought about my first Cribs show. In 2006, they opened for Death Cab for Cutie and Franz Ferdinand at Hammerstein Ballroom. I was supposed to take my high school girlfriend, but she had called me that day to let me know that she and my best friend of fourteen years had been playing a little game of hide the loose ends. I went alone and screamed along to "Mirror Kissers." Read More


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New York Gov. Andrew Cuomo will once again enter the national political bubble this evening when he watches tonight's presidential debate at Hofstra University.
The governor, a Democrat, said Obama needs to "win" tonight. It doesn't seem he will be in the official "spin" room after the town hall style forum, but Cuomo said he would be offering his thoughts.
A gubernatorial aide did not immediately clarify what that meant. Here's what Cuomo said:
"I'm going to watch and cheer the president on, and then I'll comment afterwards," Cuomo said earlier. "I retain the right to see the performance before I determine the comment. So after I watch the debate — really a town hall, so it's going to be different than the first one — then I'll comment on it ,but I'm there to support the president."
"This is going to be a different format, so I don't know that you can do apples to apples," he continued. "The first format was much different than this format. And I expect it's going to be a different dynamic and there's going to be less interchange between the two. I don't know that you're going to be able to compare the two. But to the extent people felt he wasn't that engaged or he wasn't expressive in the first debate, I'm sure that he's going to correct that in this debate."
The president has acknowledged his performance in the first debate was a bit lackluster, and Democrats are hoping tonight's exchange will help re-energize the base.
Cuomo has not been an active Obama surrogate either in person or in interviews, and sometimes declines to weigh in with a strong Democratic Party stance, even when initially prompted to defend Obama's tax proposals (the governor later clarified his support) or rate the GOP's selection of Rep. Paul Ryan as its vice presidential nominee.
Still, Cuomo is mentioned as a possible presidential contender in 2016. Others Democrats in the same pool, including Maryland Gov. Martin O'Malley, will be in the spin room on the campaign's behalf.
Cuomo lauded Obama when the president visited Albany, and again emphasized his support for the president during a speech at the Democratic National Convention.


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Events for July 11, 2016 › Sponsor
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When it comes to meeting the right people in the right place, bigger is better. The Microsoft Worldwide Partner Conference (WPC) brings together over 15,000 attendees from around the globe for a week of networking and learning—all with the goal of increasing partner profitability and accelerating business growth. If you're interested in growing your business…Find out more »


text: This image shows the Routing tab of the Configure Assignment dialog. Below this, Use External Routing is selected from the drop-down list. Below this are the words: Participants and routing defined by an external service. Below this are the words Routing Service. To the right of these words, the Edit icon is being selected.


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Stone Temple Pilots' Robert DeLeo Debuts Special Bass for New Single 'Black Heart'
Stone Temple Pilots are moving on to the second single from their 'High Rise' EP and 'Black Heart' will also hold a special place for bassist Robert DeLeo. The rocker recently told us that the nasty groove that comes from his bass was the result of him finally procuring a long sought-after instrument.
"It's special for me," said DeLeo. "I just bought and found a rare bass that I had been looking for for years. I got a chance to use it on that song, so that meant a lot too. To do that from a gear geek kind of perspective."
He went on to add, "I've been looking for this certain Rickenbacker 4001 Bass. That's a very rare 1971 Rickenbacker Bass. There were only 20 of those made in '71. It's very rare and very collectible. Growing up on Paul McCartney and Chris Squire from YES, Geddy Lee. You dream of instruments of that. Then when you find one, it's like, 'Well this is going on the song.' That means a lot, man. Dreaming about those instruments as a little kid and actually having one and using it on a song that you put together. It means a lot."
As for the song itself, the bassist reveals, "That was an idea I had. I just wanted to have something. I started out on guitar and went to bass out of necessity. I always write on guitar. I just wanted to come up with something that kind of had everything -- had great power chords, great stringy chords and parts to it. I was just feeling that one." DeLeo says after presenting it to the rest of the band, everyone started digging the track and once Chester Bennington added his vocals, it was exactly what he was wanting to hear.
The Stone Temple Pilots With Chester Bennington 'High Rise' EP featuring 'Black Heart' is in stores now. You can pick it up at this location.


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Honeybee silk-inspired materials; a deconstruction of the Ebola virus; how microbes evolve resistance to antibiotics; and a possible connection between Alzheimer's disease and type II diabetes are just some of the intriguing topics that will be presented at the 57th Annual Meeting of the Biophysical Society (BPS).
The conference will take place Feb. 2 - 6, 2013, at the Pennsylvania Convention Center in Philadelphia, Pa. With more than 6,000 research scientists in attendance each year, the Annual Meeting is the largest meeting of biophysicists in the world.
Credentialed journalists, freelance reporters working on assignment, and public information officers may attend the meeting free of charge. For more information on press registration, see below.
Preliminary Highlights
Honeybee Silk: Silkworms and spiders get most of the attention, but honeybees also make silk. Researchers are using what they have learned about bee silk to design recombinant materials with a wide range of properties and potential applications.
Presentation #248-Pos: "Artificial honeybee silk: A recombinant protein as a biomimetic structural material" http://tinyurl.com/acaztaq
Chemical Pathways of Psychosis: A broad spectrum of symptoms has been seen in psychotic disorders, but nearly 70 years of research has produced anti-psychotic drugs that alleviate only some of these symptoms and can cause significant side effects. Recent work that illuminates the complex chemical interrelationships among certain receptors in the brain could lead to better management of psychotic disorders.
Presentation #595-Pos: "Functional signaling changes resulting from GPCR heteromerization: Relevance to psychosis" http://tinyurl.com/bhhsz7h
Autism on a Cellular Level: Scientists study abnormalities within a group of chemicals associated with autism to find the mutations most likely responsible for the disease.
Presentation #118-Plat: "Functional evaluation of autism associated mutations in SLC9A9 (NHE9)" http://tinyurl.com/apjmm7a
The Modus Operandi of a Parasite: Encephalitis and other neurologic diseases are the potential consequences of an infection with T. gondii, a cousin of the parasite that causes malaria. Researchers explore how this protozoan infects its host on a cellular level.
Presentation #716-Pos: "Toxoplasma gondii targets the host actin cytoskeleton during invasion, go figure" http://tinyurl.com/am4ddxl
Seeing Cell Temperature: The temperature of a cell's inner parts can reveal much about its health. A new virtual thermometer that shows how temperature is distributed within a living cell may yield new insights into cell function.
Presentation #1033-Plat: "Imaging of temperature distribution in a living cell" http://tinyurl.com/b6dnae6
The Nanomechanical Signature of Breast Cancer: When healthy breast tissue transforms into cancerous tissue, its mechanical properties also change. Examining cells' stiffness profiles may reveal a new signature of breast cancer.
Presentation # 1639-Pos: "The nanomechanical signature of breast cancer" http://tinyurl.com/b2edbq6
Listening to Cells: Cells could have a lot to tell us, if we could only listen. A new noninvasive technique allows researchers to probe the insides of cells with sound.
Presentation # 991-Plat: "Listening to cells: A non-contact optoacoustic nanoprobe" http://tinyurl.com/a3a8oxs
Cheaters versus Cooperators: At the scale of cells, cooperators and cheaters wage constant battle. A new model shows how these two warring factions can survive in a state of perpetual conflict.
Presentation # 2530-Pos: "Diffusion of public goods prevents coexistence of cooperators and cheaters in a stochastic competition model" http://tinyurl.com/ba46sdb
Type II Diabetes and the Alzheimer's Connection: Scientists illustrate for the first time the interactions between amyloid beta and amylin, two proteins that are associated with Alzheimer's disease and type II diabetes respectively. By identifying the "hot regions" that allow one protein to bind to the other, researchers hope to provide insight into the links between these two incurable conditions.
Presentation #2008-Pos: "Investigating the interactions between Aβ and amylin: Insight into the link between Alzheimer's and type II diabetes" http://tinyurl.com/a7y6seh
Flight of the Bumblebeewith X-rays: Using ultrafast visualization, researchers examine the alternating actions of two flight muscles used by bumblebees. The work may provide new insights into how motor proteins work on a biochemical level.
Presentation #2482-Pos: "Coordination of two antagonistic flight muscles during wing-beat of bumblebee visualized by ultrafast X-ray diffraction movies" http://tinyurl.com/apxvx5c
Deconstructing Ebola: No vaccine or treatment exists for an infection with the deadly Ebola virus, which causes internal and external bleeding. To better understand how the virus assembles itself, researchers investigate the mechanistic details of a key protein using an interdisciplinary approach.
Presentation #2135-Pos: "Elucidating the mechanism of Ebola virus assembly and budding" http://tinyurl.com/bjp2dlo
A Heat-targeted Drug Delivery Scheme: Elastin-like Polypeptides (ELPs) genetically engineered proteins that respond to heat are being explored as a potential drug delivery system.
Presentation #2838-Plat: "Biophysical analysis of a novel drug delivery vector: ELP[V5G3A2-150]" http://tinyurl.com/anfecds
Blasting the Way to Brain Injury Treatment: Researchers study the effects of blast-induced traumatic brain injuries on astrocytes, star-shaped cells that play a role in the repair process for brain and spinal cord injuries. Using a device that delivers shock waves to cultures of human central nervous system (CNS) cells, they identify changes in the signaling behavior of astrocytes, suggesting a potential therapeutic target for treating CNS trauma.
Presentation #3171-Pos: "Shock waves simulating blast-induced traumatic brain injury activate purinergic signaling in astrocytes" http://tinyurl.com/asl2p6n
Vitamin D to Fight Breast Cancer: High concentrations of vitamin D at a tumor site have been proposed as a possible treatment for inflammatory breast cancer. Using quantum dots, scientists report delivering the active form of vitamin D to breast cancer tumors in mice.
Presentation #2953-Pos: "Using calcitriol conjugated quantum dots to target inflammatory breast cancer tumors and metastasis in vivo" http://tinyurl.com/acw94xg
Tracking the Evolution of Antibiotic Resistance: Antibiotic resistance is, both literally and figuratively, an evolving threat to public health. Using a device called the "morbidostat," which adjusts drug concentrations to maintain a nearly constant inhibition of bacterial growth, researchers tracked how bacterial populations acquire resistances.
Presentation #3390-Pos: "Evolution of antibiotic resistance through a multi-peaked adaptive landscape" http://tinyurl.com/bfcke65
Lung Treatments for Sickle Cell: In sickle cell anemia, malformed red blood cells decrease the amount of oxygen reaching body tissues. New research suggests that changing oxygen levels in the lungs may potentially aid in the treatment of this disease.
Presentation #2872-Pos: "Oxygen-dependent depolymerization of sickle cell hemoglobin polymers in the lungs: Kinetic mechanisms and their significance for pathogenesis and its prevention" http://tinyurl.com/a6gax45
Penetrating the Blood-Brain Barrier with Sound: Delivering drugs to the brain requires passing through the blood-brain barrier, and previous research suggests that ultrasound stimulation can help. A new model and experiments indicate that nanodrugs can indeed be taken safely into the brain by manipulating the barrier using ultrasound.
Presentation #3539-Pos: "Impact of initial vascular permeability and recovery speed of disrupted blood-brain barrier on nanodrug delivery into the brain tissue" http://tinyurl.com/adycds6
|Contact: Ellen Weiss
American Institute of Physics


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Kim Kardashian has revealed her current pregnancy weight.
The E! star is nearing her due date (Christmas Day), and shared the number she saw on the scale with six weeks left of her pregnancy. Taking to Twitter, the soon-to-be mother of two wrote, "Ok I'm 52 lbs up today....and I still have 6 weeks to go! I got my work cut out for me!!!!"
Kardashian received criticism over her weight gain from her first pregnancy with North West, and the headlines took a toll on her, as she recently recalled in C Magazine's 10th anniversary issue.
U.S. & World
PHOTOS: Kim Kardashian's pregnancy style
"It was the worst," she admitted. "I couldn't help it, and everyone would say, 'She can't stop eating.' I delivered at 180, and they were like, 'She's 210 pounds. She's getting dumped because she's too fat' and all these ridiculous stories."
"It really took a toll after the fact, when I was losing weight," adds the 33-year-old "Keeping Up With the Kardashians" star.
"I gained 50 pounds, and it's tough to get it off. I was dedicated, but also, it changed the way I viewed wanting my picture taken. Before I was always smiling, and so into being out and about. After I had the baby, I was like, these are the same people that made fun of me, and posted the stories that were so awful, calling me fat for something I couldn't control. I don't want to smile for them. I don't want to be out."
"Even if I was more confident, I just didn't feel like being that girl who was going to be smiling for every photo," she tells C Magazine. "It changed my mood; it changed who I was; it changed my personality a lot."
The pregnant star put her baby bump on full display last Saturday when she attended LACMA's 2015 Art+Film Gala wearing a cleavage-baring, semi-sheer, black lace Givenchy spring 2016 Ready-to-Wear slip and matching pants, paired with a black trench tuxedo jacket and black sandals.
Watch the season 11 premiere of "Keeping Up With the Kardashians" on Sunday, Nov. 15 at 9/8c only on E!
(E! and NBC are part of the NBCUniversal family.)
PHOTOS: 35 Naked Kim Kardashian photos


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Classes are currently being taught online. All physical facilities are closed to the public at this time, and employees are working remotely.Please visit
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This article appeared in a 2015 issue of the
student newsletter.
Rotaract Club members paint and do yard work on a homeowner's property. A total of 24 students from Eastfield College helped make up about 1,000 volunteers who participated on Addressing Mesquite Day. | Photo by Andrea Carrizales.
Byline: Andrea Carrizales, Student Staff Writer,
The Et Cetera Published: Oct. 21, 2015Many volunteers and local organizations came together Oct. 10 to do minor exterior home repairs for Addressing Mesquite Day.
Dating back to 2005, Addressing Mesquite Day began as a joint effort between the Mesquite Ministerial Alliance and the city to "address" citizens who were unable to take care of their property due to age, disability or financial impairment.
"It was a way to show love and at the same time help the community and our neighborhoods," Mesquite councilman Bruce Archer said.
Archer said the volunteers were like an "army" as they trimmed trees, painted house, performed yard work and removed debris.
"It sets our city apart in terms of setting an example for neighbors, looking out for neighbors and helping each other," Archer said.
Many Volunteers, One Goal
The honors organization Phi Theta Kappa partnered with the Hispanic Forum of Mesquite for the event. This year, the HFM had 33 volunteers. President Rachel Lopez said that this was due to the high involvement of their partner groups, the Divine Mercy of Our Lord Catholic Church and Phi Theta Kappa.
"It was very moving because community involvement is very dear to my heart," she said. "I just felt so proud to know that so many students, so many young adults were interested in giving back to the community."
The volunteers did yard work — from picking up litter to cutting tree branches and cleaning the fence — on disabled veteran Sammy Colgrove's home.
"These were chores he could not do and could not afford to pay someone else to do," Lopez said.
Students Find Joy in Giving Back
Phi Theta Kappa members and sisters Jana and Casie Burdge were among the volunteers.
"It was really fun to put on the gardening gloves and the goggles, use the hedge clipper," psychology major Jana Burdge said. "We helped clean up the yard and I got hit with a tree branch, but it was fun." She said that her favorite part about small kindness could liven up someone's day.
"He was talking about how he has retired twice from the city and how he wants to take his RV that he hasn't driven and go cross country," she said.
Both sisters said the camaraderie and welcoming environment made them want to participate again.
Alma Leal, a criminal justice major, said she enjoyed volunteering in the event. Apart from meeting new people and making friends, she said that the purpose of Addressing Mesquite Day opened her eyes to a different sector of the population.
The Eastfield Rotaract Club brought 12 volunteers who painted the exterior of the house and cleaned up the backyard of a different homeowner. They partnered with its sponsoring organization, the Rotary Club of Mesquite.
Results Grow, Hope Floats
In 2013, the city repaired its 500th house. Through the influx of volunteers and support from the community, the event surpassed its goal of helping 100 houses by an additional three this year. In total, Addressing Mesquite Day has cleaned and repaired 703 homes.
Lauren Rose, management analyst for the city and coordinator of Addressing Mesquite Day, said that the event has grown by "leaps and bounds" and that "continued growth and continued involvement" are its central goals.
Archer, who graduated from Eastfield in 1994, said he was excited about the students' involvement in the event.
"It gives our nation and our community tremendous hope," Archer said. "There's so much apathy in this nation across the board — old and young. When we see young people taking ownership of their community and wanting to serve and make a difference, it's a good sign for where we'll go in the future."
To read more news pieces from student writers at Eastfield College,
visit The Et Cetera online.


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With almost no funding, Austin filmmaker Polaris Banks made his own 35-minute fan movie about the Teenage Mutant Ninja Turtle's cricket bat-wielding vigilante friend Casey Jones. Banks got Robbie Rist, the voice of Michelangelo in the movies, to lend his pipes to the no-budget production.
You can check out some footage above (via YNN), and the film premieres online on September 17. Hat tip to Banks for using my favorite song from the soundtrack. (And no, not the MC Hammer track, a.k.a. the Foot Clan's de facto theme song.)


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LOS ANGELES (AP) — More than 104,000 students worldwide took the Advanced Placement Calculus exam this year. Only 11 got a perfect score. California 17-year-old Nathan Chou is one of them.
The Arcadia High School senior learned of the rare achievement from the College Board, the nonprofit group that oversees the AP tests.
Chou told the Los Angeles Times in a story Sunday that he spent about four hours studying for the calculus exam, with help from class-made study guides and practice tests.
"That was helpful," Nathan said. "But I almost ran out of time on the multiple-choice section. I was nervous that my memory would suddenly blank out."
The test was offered in 59 countries in the 2012-2013 school year. The 11 students who earned perfect scores are all from the United States. At least two other students in California earned perfect scores on the exam, said Deborah Davis, the board's director of college readiness communications.
Nathan took the test previously as a junior. He said the concepts were easy to understand but applying them to calculus problems was challenging.
Nathan has maintained straight A's in high school and plays the violin and piano in the school's symphony orchestra.
His father told the newspaper the family will visit one of Nathan's favorite restaurants to celebrate the accomplishment.


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About Creative Blueprint
We provide research and analysis in to the skills needs of the creative and cultural industries and their economic contribution to the UK
The Data Generator is a free data analysis service designed to help you access the latest creative and cultural industry statistics.
Pathways to Design: Young People's Entry to the Design Sector
Creative & Cultural Skills, with funding from the Sector Priorities Fund Pilot, have launched research exploring the design industry and its perceptions of the education sector, along with their current practices in recruiting young people. More info >
Quick updates
Creative Scotland appoints new Chief Executive
Janet Archer, currently Director at Dance for Arts Council England, will take up the role in July
The Culture Secretary gives her first speech on the arts at the British Museum
Maria Miller advises senior culture figures that justification for future arts funding must be based on an economic grounds
Government announce the launch of new Tech Bacc vocational
The Tech Bacc will bring together new and existing qualifications, and is aimed at the 50% of students who do not go on to attend university


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Click here to read press release
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Meet Me at the Rainbow Bridge
Kenneth Newman, DVM
Meet Me at the Rainbow Bridge begins with a tragic accident in which a careless driver backs up 25 yards without looking, pinning Dr. Newman and his beloved Labrador, Gracie, between his family station wagon and the driver's bumper. Dr. Newman's life story is narrated in retrospect, emphasizing the importance of the dogs that have shared his life. It is furthermore an appeal to the hearts and minds of pet owners that the legal status of pets must be elevated above the level of mere property, the status they are now granted in our legal system. Ninety percent of pet owners now consider their pets to be family members. The owner of a pet that is killed through an accidental act of negligence or a deliberate act of malice can only receive the cash value for their pet. Dr. Newman presents his view that the laws of the land are out of touch with the public's sentiment.
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Joseph Lambert is a cartoonist, illustrator and co-editor of the Sundays anthology. He was born in Kansas in 1984 and now lives and works in White River Junction, Vermont. A graduate from the Center for Cartoon Studies, he published his debut graphic novel 'I Will Bite You! and Other Stories' through Secret Acres in 2011. He also produced a dual biography of deaf-blind Helen Keller and her mentor Annie Sullivan called 'Annie Sullivan and the Trials of Helen Keller' for The Center for Cartoon Studies (Disney/Hyperion, 2012).
Joe Lambert's work is also included in Chris Duffy's 'Fairy Tale Comics' (First Second), 'Mome' volume 22 (Fantagraphics) and the 2008 and 2013 editions of Houghton Mifflin's 'The Best American Comics'. His illustrations have appeared in Business Week, Popular Mechanics, 7Days, The Comics Journal and many other publications.


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Whether you need a lighter for a cigar, pipe or cigarette, the wide selection of lighters at Cigars Crafters offers smokers a great choice at low discount prices. Each lighter is made to the highest quality standards and built with fine and superior craftsmanship, and with special attention to the details. Each luxury lighter is examined at the same factory and detailed to work precisely as intended. With many different exterior finishes, the lighters have beauty and elegance that is only shadowed by their performance. They are the best available and are fully guaranteed reliable.


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The truth is, and this may not shock some of you, Dallas doesn't suit me. It's not my cup of tea. Or coffee. Wine. Beer. Or even shot of whiskey. I'm not trying to insult those Dallasites that can hang here by any means. I've just come to the realization that I'm not one of those people.
I'll spare you all the details, but after a few short months in Dallas, we've decided to go back home.
To those of you, if any are still around, that read my blog, please accept my apologies for the complete lack of content these last few months. I've had a hard time finding my inspiration these days, but things should get back to normal in the new year. Just hang on.


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Suzanne Collins gave Mockingjay a distinctly definite ending, but she left out some details between the book's final events and its epilogue. The folks behind the fan film Star Squad want to return to Panem take an authorized look at the further tribulations of Katniss Everdee.
If you haven't finished the books, there are spoilers for Mockingjay below.
At the end of Mockingjay Collins briefly mentions that Katniss is put on trial for the assassination of District 13's President Coin. Seizing on this note, a trio of filmmakers wishes to make Star Squad, which will follow Katniss' trial. The movie, which will be feature-length, will also focus on the remnants of Squad 451 (the titular Star Squad) as they work to rebuild the war-torn nation.
Since this is an authorized fan-film, the crew won't be looking to make a profit, but they are asking for donations on Indie GoGo. They've got a long ways to go before they hit their $65,000 goal, but if you donate $250 or more, you'll get to sit in on the trial of Katniss Everdeen during filming and watch Hunger Games history being made.
The hopeful filmmakers include Woody Tondorf, writer and producer of Elevator Show, Caroline Framke, a writer on Hulu's The Morning After, and Brendan Bradley, creator of the series Squatters. May the odds be ever in their favor.
Star Squad [Indie GoGo via The Mary Sue]


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ORLANDO, Fla. (AP) Georgia and Nebraska are hoping a New Year's trip to Florida will be the perfect place to get over their conference championship game disappointments.
Both teams accepted bids to the Jan. 1 Capital One Bowl on Sunday, just a day after falling in their respective conference championship games.
The Bulldogs (11-2) came up just a few yards short of winning the SEC crown and trip the BCS national championship game Saturday night, losing to defending BCS champion Alabama, 32-28.
``We spent ourselves in a worthy cause,'' Georgia coach Mark Richt said. ``We, of course, wanted to play for a national championship. We knew we were just a few yards or a tipped ball, or however you want to say it away from winning it. It was heartbreaking, no doubt. We were highly hurt by it. ... So you have to kind of get over the heartbreak of that.''
For the Cornhuskers (10-3), their 70-31 loss to Wisconsin in the Big Ten title game might not have had the nail-nibbling heartbreak Georgia endured, but was just as painful. Nebraska is appearing the Capital One Bowl for the second straight season. The Cornhuskers fell 30-13 to South Carolina in last season's matchup. It is their 49th bowl appearance overall.
Coach Bo Pelini said though his team was just in Orlando last postseason, he jumped at the chance to play the highest ranked team not in a BCS bowl.
``I think it's a great opportunity for us,'' Pelini said. ``That's one of the reasons we're excited to be going. Obviously our championship game didn't go the way we wanted to. But it gives us an opportunity to play ... and we're looking forward to the challenge.''
The New Year's Day meeting will mark only the second time Georgia and Nebraska have met. Nebraska defeated the Bulldogs, 45-6, in the 1969 Sun Bowl.
It will also be farewell to former longtime coach and current Nebraska athletic director Tom Osborne, who will retire from that position on Jan. 1 as well.
Georgia won the SEC East division title for the second consecutive year. It is making its sixth appearance in the Cap One, having last beaten Michigan State in 2009. This will be the Bulldogs 48th bowl game.
This second matchup between Nebraska and Georgia is expected to be much closer than the first.
Georgia thrived this season offensively behind Tampa, Fla. native and junior quarterback Aaron Murray. He leads the nation in yards per passing attempt (7.8), while throwing for 31 touchdowns.
Defensively the Bulldogs had the SEC's second-ranked pass defense, allowing just 120 yards per game. Linebacker Jarvis Jones has been a big part of that, with 12.5 sacks on the year.
Richt said he thinks the prospect of winning a 12th game will help his team turn the page quickly during bowl practices.
``We've got a bunch of really great seniors that are really great men of character that love the game of football, love playing and playing with their teammates,'' Richt said. ``I don't think it will be that great of a challenge (refocusing), frankly...I think playing Nebraska will get everybody's blood pumping. I don't think it will be an issue. I know our guys want to finish strong.''
The Cornhuskers also have a capable signal caller in junior Taylor Martinez. He is Nebraska's all-time career leader in total offense with more than 9,000 yards.
Martinez has also gotten a lot of support from running backs Rex Burkhead and Ameer Abdullah, a tandem that lead the most productive rushing attack in their conference, averaging 254 yards per game.
Knowing the high-powered rushing attacks that dominate the SEC, Pelini said the team that is able to establish the run Jan. 1 will have the most success in this matchup.
``You give up big rushing yards and it's a recipe for disaster, and I know it was for us'' against Wisconsin, he said. ``That's gonna be an area that both teams are gonna have to sure up and probably an area that both teams try to exploit.''
Follow Kyle Hightower on Twitter athttp://www.twitter.com/khightower .


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Filled with a colorful choice of music stemming from all over the world,
Inspired by the title track "New York Fantasy - All The World In One City", Duo Stoyanova.
The title track "New York Fantasy - All The World in One City" inspired the twin sisters for their first CD. These compositions, from different countries with various sounds and rhythms combined into a lively musical palette, capture the spirit of Harlem jazz clubs to China town or of the flamenco. Music trip with modern works, which push us on many image associations and fantasies thanks mostly to the brilliant and temperamental interpretations.


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May 17, 2007 -- The number of teens, especially girls, taking prescription drugs for type 2 diabetes, sleep problems, and other illnesses is up.
That's according to a new report from Medco Health Solutions, which manages pharmacy benefit programs.
The report charts Medco's prescription drug claims for some 370,000 girls and boys aged 10-19 from 2001 to 2006.
The sharpest rise in prescription drug claims was for girls taking drugs for type 2 diabetes, which is usually seen in adults but has become more common in kids and teens as childhood obesity rises.
Increases were also seen in drugs for attention deficit hyperactivity disorder (ADHD) drugs, antidepressants, type 1 diabetes, antipsychotics, and sleep aids -- with girls leading the growth in all of those drug classes.
"This analysis raises concerns and questions about the health of adolescents in America, particularly girls," says Robert Epstein, MD, Medco's chief medical officer, in a Medco news release.
"While this may be evidence that more girls are for the first time being appropriately diagnosed and treated, it also raises red flags about the physical and psychological problems afflicting this population," Epstein notes.
Type 2 Diabetes Drug Trends
Medco reports that in 2001, about one in 1,000 girls aged 10-19 took type 2 diabetes drugs. That figure rose to 2.7 per 1,000 girls in 2006, an increase of 167%.
Most of that growth occurred during 2002-2005, according to Medco's data.
In comparison, Medco reports that prescription drug claims for boys aged 10-19 taking type 2 diabetes drugs rose by about 33% during the same time. However, less than one in 1,000 boys took type 2 diabetes drugs throughout that period.
Teen Sleep Prescriptions Up
Most recently, prescriptions for sleep aids showed the sharpest rise for boys and girls alike.
From 2005 to 2006, the prevalence of girls aged 10-19 with prescriptions for sleep aids rose by about 12%, from 3.9 per 1,000 girls in 2005 to 4.37 per 1,000 girls in 2006.
During the same period, the prevalence of boys aged 10-19 with prescriptions for sleep aids rose by more than 18%, from 2.5 per 1,000 boys in 2005 to three per 1,000 boys in 2006.
Here is the complete list of growth in prescription drug claims for 2001-2006 in girls and boys aged 10-19:
- Attention deficit hyperactivity disorder (ADHD) drugs. Up nearly 74% for girls and 37% for boys
- Antidepressants. Up more than 9% in girls and less than 1% in boys
- Type 1 diabetes drugs. Up nearly 17% in girls and almost 10% in boys
- Type 2 diabetes drugs. Up nearly 167% in girls and about 33% in boys
- Antipsychotics. Up more than 117% in girls and almost 71% in boys
- Sleep aids. Up more than 80% in girls and about 64% in boys


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Heroin use increases across Wisconsin
Family hopes to spread word about illegal drug
State officials said heroin use has more than doubled in Wisconsin since 2009.
A Beaver Dam couple is working to bring awareness to the drug that took their son.
"Jake was a son, brother, grandson, nephew, cousin and friend to many," mother Stacey Schultz said.
"Jake didn't lose a battle with addiction. Heroin killed him before he had a chance to develop one," father James Schultz said.
Stacey and James Schultz read from a letter entitled "I Knew Jake."
"I want them to know this isn't somebody that somebody made up to scare them away from drugs. This is a real person," Stacey Schultz said.
Jake Schultz had just turned 22 years old. His family believed he was drug-free until he stopped breathing and died in the family's living room in November after taking heroin one night earlier.
"That was something somebody who lived under a bridge did. It wasn't something that a kid that went to Beaver Dam High School would do," James Schultz said.
Shocked that heroin was in Beaver Dam, they're now passing out a letter to whoever will read it to let people know heroin is a problem.
"Heroin has made a surge in Wisconsin," Wisconsin Department of Justice Director of Field Operations David Spakowics said. "Fox River Valley is having a very difficult time with it right now, and it's spreading into our rural areas, and that is surprising."
Since 2009, the number of reported heroin cases to the state crime lab increased 68 percent, and for the first time in 2011, reports of opiate use bypassed cocaine by 22 percent.
"We've seen people go from marijuana – no other drugs ever tried – right to heroin because that stigma is no longer there," Spakowics said.
The supply route has moved from the East Coast to Chicago.
"Because of our close proximity, we're seeing traffickers drive down there two, three times a week because it's only 90 miles away," Spakowics said.
"My first and only tattoo – my memorial to Jake," Stacey Schultz said.
While Jake's family continues to grieve, their mission now is to make sure as many people in Dodge County and throughout Wisconsin know their son's story and sit down and discuss an issue that's not going away anytime soon.
"I miss Jake, and I don't want anyone else to go through this pain," James Schultz said.
There were 24 known deaths from heroin use in 2011, and the number is expected to increase in 2012.
Milwaukee, Waukesha and Marinette counties have the most heroin cases reported this year, followed closely by Walworth, Dane, Washington, Winnebago and Brown counties.


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VIDEO: Highlights from Wheaton/Webster / Postgame Press Conference
GRAND CHUTE, Wis. - Sophomore Alec Palioca (Wrentham, Mass./King Philip) tossed 7.1 innings of one-run ball to propel the No. 9 Wheaton College baseball team to its first College World Series win since 2006, a 3-2 triumph over Webster University Friday afternoon at Time Warner Cable Field at Fox Cities Stadium.
Junior Sean Ryan (Norton, Mass.) and freshman Apolinar De la Cruz (Providence, R.I./Classical) each drove in first-inning runs for the Lyons (39-9), who advance in the winner's bracket and will play at 4:30 p.m. on Saturday against the winner of Kean-Cortland St. contest. With the win, Wheaton improves to 5-2 all-time in the College World Series and 5-1 in the NCAA Tournament this spring.
Senior Hal Landers (Salem, N.H./Salem) and junior Eric Jensen (Gorham, N.H./Gorham) opened the first with back-to-back singles, putting runners on first and third with no outs. Ryan grounded out to first to bring in Landers for a 1-0 lead, and De la Cruz laced a single to right two batters later to plate Jensen from second.
The Gorloks cut their deficit in half in the third as junior Cody Stevenson (Salem, Ill.) tripled to left-center field and scored on an RBI single to center by classmate Taylor Stoulp (St. Louis, Mo.). Wheaton got the run back in the fourth as a pickoff attempt at second base with the bases loaded went into center field, allowing junior Dan Gusovsky (Andover, Mass./Andover) to score from third.
Webster touched up sophomore closer Ryan Grant (Easton, Mass./Oliver Ames) for a run in the ninth on an RBI single by sophomore Kevin Kojs (New Lenox, Ill.) before recording the third out for his 13th save of the season.
Palioca, meanwhile, allowed eight hits and one run with no walks and eight strikeouts to record his program-record ninth win of the season. He is tied with junior teammate Frank Holbrook (Middletown, R.I./Portsmouth Abbey), who picked up his ninth win of 2012 in the Lyons 2-0 win over Western New England in the New England Regional Championship on Sunday.
Senior David Mueller (Webster Groves, Mo.) started on the bump for the Gorloks (35-13) and allowed five hits and three runs (two earned) in seven innings. He walked one and struck out seven to fall to 8-3 on the season).
Landers finished the afternoon with two hits while Kojs went 3-for-4 for Webster, which places in the 10 a.m. game on Saturday against the loser of the Kean-Cortland St. contest.


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Elemental but invisible
We cannot see it but we need it to live – and to fly through the sky. In praise of air.
When you're flying 9000 meters above the ground and look out of the window, what do you see? Most people would say: clouds, sky and the earth far below. They wouldn't say: air. We know of the existence of this invisible mixture of gases, but we seldom think about it. We cannot grab a hold of air and usually cannot smell it. It is beyond our senses' perception.
The fact that we associate air with absence, with something that isn't there, is reflected in our speech. If someone disappears suddenly, we say they have vanished into thin air. A person who talks nonsense is full of hot air. To make unrealistic plans is to build castles in the air. And baseless theories can be said to be plucked out of the air. It's as if our mind wanted to deny the existence of this omnipresent element. But what would we be without it? We need it to breathe, we need it to live. And naturally, we need it to fly. Without air, no plane could take off and no bird could glide through the sky. The time has come to pay tribute to the ethereal element flowing past our window.
For a long time, humans didn't understand the concept of air. What was it that we breathed and were able to forcefully expel? Nothingness? The breath of God? The Greek natural philosopher Anaximander was one of the first to attempt an explanation. Around 600 BCE, he is said to have described what surrounds the earth and what humans feel when the slightest breeze blows like this: "Wind is a flowing of air." What sounds self-evident to us was a revelation back then.
Observe the fish in the water and you will understand the birds in the air
In the third century BCE, Philo of Byzantium discovered that air was a substance, but it wasn't until roughly 1800 years later that Galileo Galilei succeeded in proving that air actually had weight. This was a bold assertion in an age when people had a hard time believing earthly explanations for things they couldn't see. In the end, it was the quicksilver experiments conducted by Italian physicist Evangelista Torricelli that convinced them. Torricelli filled quicksilver into small glass tubes and was amazed to observe its level rise and fall according to the weather. This resulted in the invention of the barometer, a device capable of measuring the pressure applied to the earth by enormous masses of air and the key to understanding weather. From then on, it was accepted that air was not nothing but rather something quite concrete.
In fact, our atmosphere, which is roughly 100 kilometers thick, does weigh heavily on the planet. One cubic meter of air weighs just under 1.3 kilograms. Applied to the pillar of air directly above our heads, that's the equivalent of roughly ten tons of air per square meter of ground at sea level – and a weight of around 17 tons bearing down on each of us. Yet we feel none of it, because our bodies naturally exert the same amount of pressure to create an equilibrium.
Today, our air is made up of 78 percent nitrogen, 21 percent oxygen, 0.9 percent argon and other noble gases and 0.04 percent carbon dioxide, not to mention dust, steam, sulfur and nitrogen compounds, exhaust fumes, and plant and animal microorganisms. It's quite a colorful mixture. People like pilots, who concern themselves with air, have a very clear picture of what it is and does. And the experts, like the inventor of the barometer, Torricelli, no longer talk about humans living on the surface of the earth but rather on the floor of an ocean of air.
This ocean of air is very alive, continually moving and flowing, forming eddies and waves and vortices. Sometimes it's thick, sometimes thin, sometimes warm, sometimes cool, but it is never still. Even on a perfect, "windless" summer's day, billions of molecules dance furiously around us. Storms rage in the air and waves crash in this invisible sea. Everything that moves in the air leaves a trail behind, interrupting the flow like a post in a swiftly moving river.
Airplanes cross this invisible sea, plow through this intangible ocean of air as they navigate its heights and depths. En route, they encounter the most curious laws. They create c, their own wake of vortices, so to speak. In fact, air sometimes moves so rapidly that pilots find themselves navigating its currents like a ship's captain navigates the sea. The narrow, fast-flowing currents of air known as "jet streams" sometimes shoot across the sky at over 200 kilometers an hour. Pilots enter them to tap into their speed. There are actually two speeds in the sky: One is measured relative to the air and the other relative to the ground. A pilot flying at an air speed of 600 kilometers an hour might be moving at a ground speed of close to 800 kilometers per hour. The air can also hinder a plane's progress, however, which explains why flying out in one direction can take longer than flying home in the other.
Ultimately, it is the weight of the air that makes it possible for an airplane to take off. Its wings cut through the air and its molecules flow around the curve of the wings, faster along the top than along the bottom. This creates lower pressure on the top and higher pressure on the bottom so that the wings are lifted into the air. The Swiss physicist Daniel Bernoulli formulated the basic principle of flight when he described this effect in the 18th century. We can observe this phenomenon elsewhere, too: When you stick your head out of the window of a moving car, the wind doesn't blow your hair into the car but rather pulls it out. Strong winds don't make roofs collapse into houses, they lift them off.
In the end, there is also something philosophical about the air. It silently challenges us to investigate the reality behind what's in the world, to discover the things we cannot see. This makes the air as miraculous as an invisible sea. The universal thinker and inventor Leonardo da Vinci already saw the parallels a good 500 years ago: "Observe the swimming of fish in the water and you will understand the flight of birds in the air."


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Tagged: Texas Rangers
4-14-10 Progressive Field
It was time for my return to Progressive Field in Cleveland. Of the ballparks that I've traveled to, I enjoy ballhawking most at Progressive Field.
I arrived at 3:30 and was second in line behind fellow Pittsburgh ballhawk Nick Pelescak.
When the gates opened, I was hoping to fill my pockets with Easter Eggs. Alas, I only found one ball, despite looking in virtually every row and seat. At the very least, I was on the board.
My second ball of the day was from Indians reliever Chris Perez. A ball rolled to the warning track and several of us asked for it.
Sweet spots:
Game: 7 balls (3 hit, 1 thrown, 3 found)
Season: 24 balls (13 hit, 3 thrown, 5 device, 3 found)
Games: 5 games
Average: 4.80 balls per game
Career: 602 balls
Streak: 101 consecutive games attended with at least 1 ball snagged.
Attendance: 10,071
2009 through 5 games: 20 balls (Four balls ahead of last year's pace)
I'll close with another brief youtube video that I took from left field:
8-12-09 Progressive Field
I decided to make the trip back to Cleveland for the second consecutive day. The previous day, I had snagged twelve baseballs. However, today, I would struggle a bit.
I was the first one in line, and therefore was the first fan into the seats. I immediately started looking for Easter Eggs. Usually, the seats are littered with baseballs. Not today. Not a single Easter Egg anywhere. Either an usher or employee had picked them all up, or the Indians did not take their customary early cuts in batting practice.
I would have to try and earn some the old fashioned way.
I had my first chance at a ball that landed a few seats away from me. I was moving toward the ball, but wasn't fast enough to get to the spot before it landed. The ball hit off of a chair and popped straight up in the air. I started to reach up to grab the ball barehanded when some teenager a row up from me appeared seemingly out of thin air, and jumped to grab the ball just as it was about to land into my outstretched hand. I was pretty mad with myself.
Later, another home run was hit, and I scurried over to the spot. The ball landed in an empty row behind me, so I bent down to scoop the ball up with my glove. Never pick up a ball with your glove. The ball was firmly in my glove, and I had begun to lift it up, when a man grabbed onto my glove and ripped the ball out of it. I glared at him and said, "Wow, are you serious?"
Apparently not, because he immediately tossed me the ball. I don't know if he had done it was a joke or what. Then I had to deliberate whether or not to count the ball in my collection.
Any ball tossed to me or given to me by a fan does not count. I eventually decided that since I had clear possession of the ball first, it would count. I further concluded had the man snatched the ball from me and not given it back, I still would've counted it. It was not a great way to get ball #1, and I needed to get more.
I continued to try and get batted balls in the right field/center field seats.
Balls just weren't coming at me today. To make matters worse, the Indians portion of batting practice was just about over, and the seats were getting cluttered with fans.
There weren't many fans, just enough to block up every one of the first 10-15 rows, thereby limiting my range.
Game: 4 balls (1 hit, 3 device)
Season: 279 balls (142 hit, 85 thrown, 52 device)
Games: 58 games (5 of which didn't have BP)
Average: 4.81 balls per game
Career: 445 balls
Streak: 73 consecutive games attended with at least 1 ball snagged.
Attendance: 18,794
8-11-09 Progressive Field
Today was a weird and unconventional snagging day. I would catch zero balls off the bat, and only snag one ball thrown by a player. Yet, somehow I managed to break double digits.
I was the second one in line when I got to the gate. About fifteen minutes before the gates were to open, the old woman in front of me spared two of her friends, a father and his daughter, a little girl of about six years old. Little did I know that the daughter would go on to snag 12 balls of her own today, and assist me with three of my snags.
When the gates opened, I ran in to the bleachers and immediately found ball #1 about six rows back. I continued towards the visitor bullpen, and found ball #2 sitting in an aisle seat. I continued on towards the visitor bullpen and found ball #3 lying in the front row.
I wasn't done searching. I walked over to the Indians bullpen and saw a ball laying in the front row. There were people standing in front of it, but hadn't noticed it laying underneath the chair behind them. I walked in the second row, bent down, and picked up ball #4. It was extremely water-logged. I tried to write '433' on it, but it was just too wet. I'll have to wait until it dries out to re-label the ball.
When I picked up ball #4, I immediately noticed ball #5, which was about fifteen feet out, on top of the Indians bullpen.
I went to work. I tossed my glove out and pulled it in, knocking the ball a good ten feet or so closer. I took out my 'Cleveland Stick,' the collapsible six foot yard stick, and hooked the ball towards me. I reached over and grabbed the ball, for my fifth of the day. The father and daughter who were in line in front of me watched me make the snag.
After finding those first five balls, I tried to play for home run balls.
Game: 12 balls (4 hit, 1 thrown, 7 device)
Season: 275 balls (141 hit, 85 thrown, 49 device)
Games: 57 games (5 of which didn't have BP)
Average: 4.82 balls per game
Career: 441 balls
Streak: 72 consecutive games attended with at least 1 ball snagged.
Attendance: 21,870
4-25-09 Oriole Park at Camden Yards
I was looking forward to my first ever trip to Camden Yards. I should've known that something was up though because before leaving, I filled up my half empty gas tank with 6.66 gallons of gas. Not good.
I drove to Baltimore and checked into the Ramada Lord Baltimore (Radisson) hotel.
And right before 5PM, there were hundreds of people that snaked off into the distance and behind the Sports Museum.
This was not a good sign for batting practice.
The gates opened and I ran into right field first. It would be the last time I would run for somewhile. There was me and some other guy in the section. I long home run was hit within the first minute. It landed about 10 rows behind me, closer to the other guy. He ran to get the ball. I also ran to get the ball. We both ran to where the ball had landed but couldn't find it. I then noticed some movement under the seats. It was rolling down the stairs under the seats. It was two rows ahead of me. I attempted to stradle a row of chairs to get to it quickly. The drop must've been more than I expected because my foot landed awkwardly and immediately rolled over. I went down like a pile of bricks. The other guy saw what happened and ran over and snatched the ball. I was in a lot of pain. I had to sit down for a couple minutes. I tried to stand up but couldn't walk. My ankle was in bad shape. Should I go home or continue on?
I toughed it out and limped over to left field. Since I had season tickets for this game, I had an extra 30 minutes with only season ticket holders. There were a few balls hit out, but I had absolutely no range. Usually I can cover at least one full section to my left or right to chase a home run. Now? Maybe 2-3 seats either way. A home run landed near me, but I wasn't able to get to it in time. Some teenager ran over and grabbed it and screamed "It's mine!!!" and started celebrating like he had caught Joe Carter's 1993 Game 7 World Series walk off home run. I really wasn't in the mood.
Several minutes later another home run hit and bounced diagonally directly to me. I bent over gingerly and picked up ball #1.
Right before the stadium opened to the general public, another home run was hit. It was directly at me. I barely had to move. I caught the home run on the fly.&
nbsp; It was ball #2.
The stadium really filled up with people. Being from Pittsburgh, it was by far the most crowded batting practice I had ever seen.
I was extremely irritated.
The Rangers must have been having their own Home Run Derby competition, because it was insane the amount of home runs they were hitting, and how far they were hitting them. Josh Hamilton hit one over the batter's eye, and peppered a few more off of it. He was also hitting opposite field shots into the left field seats. Balls were landed a good 25 rows back.
I wasn't able to get anything though.
I went over to center field to check out the bullpens. There was 10 balls sitting in the grassy area to the right of the bullpens beneath the batters eye. I met and chatted with another ballhawk who said that the pitching coach usually comes out and tosses the balls up. There was one ball at the very back that was about 10 feet out. However, it was a big drop between the seats and the grassy area against the batters eye. I would've used the glove trick, but I figured I'd save myself the aggravation and just wait for the pitching coach.
An Orioles bullpen catcher came out and started getting the balls. Myself and the other ballhawk asked politely for the balls. He totally ignored us. He gathered all of the balls, most if not all were hit by Texas Rangers, and put them in the ball bag. I'm real sure that pitchers want to warm up with balls that were crushed 420+ feet. No wonder the Orioles lost today.
I took my seat in the 6th row, almost directly behind home plate.
It was pretty good foul ball territory, since I was right on the aisle.
I took a few shots of the game.
Josh Hamilton:
Nick Markakis got the biggest ovation of the night from Orioles fans.
I ended up leaving the game in the 4th inning as I noticed a huge bulge in my sock. My ankle was swollen really bad. After sitting down for a few innings, I could barely even walk. I made it to the outside of the stadium and flagged down a taxi to take me back to my hotel room.
I snapped this picture in the mirror of the balls I caught today. I wasn't happy.
I had tickets for Sunday's game, but found a buyer for them. They came and picked up the tickets on Sunday morning at my hotel. There was just no way I could go to the game. I'm at home now, and can't put any substantial weight on my ankle without pain.
Hopefully my ankle can heal enough so I can get to some games this week.
Game: 2 Balls (2 hit)
Season: 50 Balls (19 hit, 25 thrown, 6 device)
Games: 11 Games (9 with BP, 2 without)
Average: 4.55 Balls per Game
Career: 216 Balls
Attendance: 41,160


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By Jim Burke, Men's Golf Coach
The Men's Golf Program experienced a trip of a lifetime in England and Scotland. The trip was made possible by the efforts of those who arranged the daily details, hosted us during our tour and fundraised in advance. Following is a day-by-day recap of the people and experiences that made this trip wonderful. The warm welcomes that we received throughout the trip made our experience all the more special and memorable.
Day 1 - Practice round at Royal St Georges: Thank you to Peter Fawcus, Assistant Secretary, at St Georges for accommodating us. After travel delays we showed up over an hour late for our tee times and he simply took care of us without missing a beat. Also thank you to Bruce Monrad for the tee gift and a personally autographed book by F.R. Furber which details the history of Royal St. Georges.
Day 2 - Tournament at Royal Cinque Ports: Thank you to Secretary Ken Harrah for letting the members of the team participate in the Prince of Wales Challenge Trophy. Also, thank you to Ken for letting me join a two ball that was short a player in the event. I joined the group on the second hole upon our arrival to the course. I ended up playing with the eventual winner of the event -- Brian Ingleby. The other player in the group, Arim Habibi, had the low round of the day (-3) 69. Both players played shots around the green that I had never seen before (putts from 50 yards!) and I was able to learn a lot about how links golf is played.
Day 3 - Tournament at Royal St Georges: Thank you to Secretary Christopher Gabbey for letting the members of the team play in the Challenge Cup. The course showed its true metal and "won" as only one player broke 150 in the 36 hole event!
Day 4 - Match with Cambridge/Oxford: Thank you to John Valley the Captain of the Cambridge golf team and leader of the Oxford Cambridge Golf Society. OCGS is renowned for winning the match the night before. His plan of keeping the team out all night backfired as we were able to outlast the mixed team of Cambridge and Oxford. The team and I were fortunate to experience the social aspect of UK golf at its finest in the 36 hole foursomes match play event and John was a terrific host.
Day 5 - Match with Royal Lytham and St Annes members: Thank you to Secretary Graham Cochrane, Head Professional Eddie Birchenough, and Captain Paul Gardner. I was amazed by the generosity and friendliness that the club showed towards the team. The day at Lytham was the highlight of the trip for many and I attribute this to our hosts welcoming spirit.
Day 6 - Played at Royal Liverpool: Thank you to our driver Jeff Costello from Dundee Scotland. We were often running behind and Jeff was very understanding. Jeff provided structure to the trip and a great deal of patience. The experience would have been significantly reduced by a less accommodating driver.
Day 7 - Played at Muirfield: Thank you to Coach Paterson for setting up and organizing such a wonderful trip. Golf in England and Scotland is plastered with history and tradition and, much like Coach Paterson, it is bound to the integrity of the game. Once we arrived in Scotland, at least one person at every stop asked us to pass along their greetings and respects to Coach Paterson.
Thank you to Ernie Monrad for his generous donation to the trip. He would have proudly enjoyed observing the young men of Harvard interact with all the fine gentlemen during a fantastic lunch at the Muirfield clubhouse.
Day 8 - Played at St Andrews: Thank you to the parents and the Friends of Harvard Golf. Because of your support we were able to make memories that will last a lifetime. Playing St Andrews is like going to a great museum. There are a lot of tourists and everyone enjoys the fine art.
Day 9- Visited the Clubhouse of the R&A / Played at Kingsbarn: Thank you to Dr. Greenhough for inviting us into and providing a tour of the R & A Clubhouse. The history on display was incredible. We were all intrigued to learn that there is a button in every room that you could press and be personally served a drink in seconds. Kingsbarn was the perfect course to finish a fabulous trip. The views of the Scottish coast rival those of Pebble Beach.
Day 10 - Traveled Home: Thank you to all that support H Golf we are all blessed and grateful to have had such an unforgettable experience.


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New study represents major breakthrough in macular degeneration
University of Kentucky researchers, led by Dr. Jayakrishna Ambati, have made an exciting finding in the "dry" form of age-related macular degeneration known as geographic atrophy (GA). GA is an untreatable condition that causes blindness in millions of individuals due to death of retinal pigmented epithelial cells.
The paper, "ERK1/2 Activation is a Therapeutic Target in Age-Related Macular Degeneration" appears in the current online issue of the premier journal Proceedings of the National Academy of Sciences.
Ambati, professor of physiology, and professor and vice chair of ophthalmology and visual sciences at UK, is a leader in the field of macular degeneration research. Previous research from the Ambati laboratory published in the journal Nature showed that in human eyes with geographic atrophy there is a deficiency of the enzyme DICER1, leading to accumulation of toxic Alu RNA molecules in the retinal pigmented epithelium. Another paper published in the journal Cell showed that when these RNAs build up in the eye they trigger activation of an immune complex known as the NLRP3 inflammasome. In turn, this leads to the production of a molecule known as IL-18, which causes death of retinal pigmented epithelial cells and vision loss by activating a critical protein known as MyD88. Importantly, Ambati and colleagues found evidence that activity of the inflammasome, IL-18, and MyD88 were all increased in human eyes with GA. They then showed that blocking any of these components could prevent retinal degeneration in multiple disease models. The researchers are excited that blocking these pathways could herald a new potential therapy for GA, for which there is no approved treatment.
In the current paper, the authors show that Alu RNA, which increases following DICER1 deficit, activates a family of enzymes known as extracellular-signal-regulated kinases (ERK) 1/2. ERK 1/2, which are also known as classical mitogen-activated protein kinases (MAPKs), were found to be increased in the RPE of human eyes with GA and shown to be key mediators of RPE cell death. This work further defines the mechanisms of cell death in human GA and identifies a new therapeutic target for the dry form of AMD.
Explore further


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A man and a woman were found dead at the Beverly Hilton hotel in an apparent murder-suicide, according to reports citing the Beverly Hills Police Department and spokesman Lt. Mark Rosen.
The police responded to a report of a shooting late Friday night and found the "elderly" duo dead as a result of gunshot wounds.
The police have not released the names of the victims and will not do so until their families have been notified. The Daytime Emmy Awards are set to take place at the hotel Saturday evening, but it remains unclear if there is any connection between the two.
It was just four months ago that Whitney Houston was found dead in her bathtub at the same hotel on the eve of the Grammy Awards. She was set to attend Clive Davis' pre-Grammys party.
The Daytime Emmys, which honor the best in soap operas and daytime talk shows, air on HLN at 8 p.m.


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It is unfortunately difficult to ride a bicycle on public streets in most parts of the country without running into someone expounding on all the ways that bicycles hinder auto traffic. While there is no denying that a car has occasionally been slowed by a cyclist, the more realistic truth is that cars do a much better job of slowing each other down than a cyclist cruising in a bike lane ever will. In fact, that cyclist is actually helping by removing one car from that traffic snarl.
One thing to keep in mind, however, is that on the whole California cyclists do have the governmental support – even if sometimes that doesn't trickle down to the general population.
This was brought to the forefront of my thoughts with a tweet from The Path Less Pedaled:
whoa. a CalTrans page all about bike touring! http://1.usa.gov/l4f7x7
I was a little surprised myself when I followed the link to that page. In fact it does have some good information. The page is specific to District 1, which according to the supplied map is the area around along the coast north of Napa and Sonoma. Honestly this has got to be one of the more beautiful parts of the state, and if there was to be anywhere that deserved this much cycle touring attention, this would seem to be a good candidate.
The guide features maps, as well as documents on bicycle related topics such as cycling related laws, safety tips, and a rather handy list of contacts in each of the 12 Caltrans districts for all things bicycle related.