text:
Department of Health and Human Services
Participating Organizations
National Institutes of Health (NIH), (http://www.nih.gov/)
Components of Participating Organizations
National Institute of Mental Health (NIMH), (http://www.nimh.nih.gov/)
Title: Implicating Noncoding RNAs in the Genetics of Mental
Disorders (Collaborative R01)
Announcement Type
Request For Applications (RFA) Number: RFA-MH-07-041
Catalog of Federal Domestic Assistance Number(s)
Key Dates
Release Date: May 11, 2006
Letters of Intent Receipt Date(s): June 21, 2006
Application Receipt Date(s): July 21, 2006
Peer Review Date(s): November/December 2006
Council Review Date(s): January 2007
Earliest Anticipated Start Date(s): April 2007
Additional Information To Be Available Date (Url Activation Date): Not Applicable
Expiration Date: July 22, 2006
Due Dates for E.O. 12372
Not Applicable
Additional Overview Content
Executive Summary
Table of Contents
Part I
Overview Information
Part II Full Text of Announcement
Section I. Funding Opportunity Description
1. Research Objectives
Section II. Award Information
1. Mechanism(s) of Support
2. Funds Available
Section III. Eligibility Information
1. Eligible Applicants
A. Eligible Institutions
B. Eligible Individuals
2.Cost Sharing or Matching
3. Other - Special Eligibility Criteria
Section IV. Application and Submission Information
1. Address to Request Application Information
2. Content and Form of Application Submission
3. Submission Dates and Times
A. Receipt and Review and Anticipated Start Dates
1. Letter of Intent
B. Sending an Application to the NIH
C. Application Processing
4. Intergovernmental Review
5. Funding Restrictions
6. Other Submission Requirements
Section V. Application Review Information
1. Criteria
2. Review and Selection Process
A. Additional Review Criteria
B. Additional Review Considerations
C. Sharing Research Data
D. Sharing Research Resources
3. Anticipated Announcement and Award Dates
Section VI. Award Administration Information
1. Award Notices
2. Administrative and National Policy Requirements
3. Reporting
Section VII. Agency Contact(s)
1. Scientific/Research Contact(s)
2. Peer Review Contact(s)
3. Financial/ Grants Management Contact(s)
Section VIII. Other Information - Required Federal Citations
Part II - Full Text of Announcement
Section I. Funding Opportunity Description
1. Research ObjectivesPurpose
The purpose of this RFA is to support research that characterizes the role of microRNAs and other noncoding RNAs in the etiology of mental disorders. The data generated by this effort will contribute to the disaggregation of the molecular machinery underlying mental disorders by integrating sequence specific modulators of post-transcriptional gene expression into a theoretical framework of disease pathophysiology.Background
Noncoding or non-messenger RNAs are diverse molecules with structural, enzymatic and regulatory functions that are surprisingly prevalent in the human genome and play a critical role in the regulation of gene expression. According to their origin or function, three types of naturally occurring small RNAs have been described: short interfering RNAs (siRNAs), repeat-associated short interfering RNAs (rasiRNAs) and microRNAs (miRNAs). Large-scale cDNA analysis and genome annotations predict thousands of noncoding RNAs and computational analyses suggests that over 20% of human genes are regulated by miRNAs. MiRNAs are sequence specific regulators of posttranscriptional gene expression and though only about 20 nucleotides in length they are believed to regulate the expression of thousands of target mRNAs, with each mRNA believed to be targeted by multiple miRNAs. MiRNA mediates gene expression either through messenger RNA cleavage or by translational repression. Generally, if a miRNA target duplex contains imperfect complementarity, protein expression is inhibited without target mRNA destruction. However, if the duplex has nearly perfect base pairing the mRNA target is marked for degradation.
The potential importance of noncoding RNAs is suggested by the observation that the complexity of an organism is poorly correlated with its number of protein coding genes, yet highly correlated with its number of noncoding RNA genes, and that in the human genome only a small fraction (2−3%) of genetic transcripts are actually translated into proteins. A systematic analysis of transcription observed about 10 times more transcriptional activity than can be accounted for by predicted protein-coding genes. Much of this activity was subsequently shown to be regulated. These and other findings support the notion that miRNAs have a central role in the regulation of protein translation throughout the human genome. Understanding the mechanisms of RNA silencing may shed light on human disease. While the biological functions of most miRNAs are unknown, some have already been found to be of relevance to understanding the genetics of mental disorders and cancer. For example, in Fragile X syndrome the dFmr1 protein regulates the translation of its mRNA via miRNA interaction. Other studies have linked diseases to the loss of miRNA expression that may result from the deletion or the translocation of a chromosomal region.
This initiative will focus on genome wide approaches to characterize the role that miRNAs and other noncoding RNAs play in the etiology of mental disorders. Projects to be funded under this RFA include determination of the expression of computationally predicted microRNAs by high-throughput miRNA microarray analysis; and validation of the sequence of predicted miRNAs that give high signals on the microarray using state-of-the-art sequence-directed cloning and sequencing methods. A particular focus of this initiative will be the characterization of inadequate, spatially aberrant or mistimed expression of a functional protein as modulated by noncoding RNAs. Alterations in protein expression attributable to these novel mechanisms are expected to play a significant role in the etiology of mental disorders. One or more susceptibility genes for mental disorders may turn out to include abnormal transcriptional units that code for RNA regulators of protein coding genes or to be proximal to such units, rather than to be abnormalities in the protein coding gene itself. Understanding the genetics of mental disorders might very well include consideration of RNA regulation of protein expression.
This RFA encourages grant applications for research in a number of critical areas including but not limited to:
See Section VIII, Other
Information - Required Federal Citations, for policies related to this
Section II. Award Information
1. Mechanism(s) of Support
This funding opportunity will use the NIH Research Grant (R01) award mechanism. R01s will be submitted as a linked group or set of R01s, usually one R01 per participating PI. For each set of linked collaborative R01 applications, it is expected that each application will be coordinated and interlocked with the others as each application will contribute an essential component to the overall study. In the case of multi-site clinical trials, it is anticipated that the same protocol will be submitted by each site. However, there are likely to be elements unique to some sites (e.g. data coordination, fidelity assessment, statistical analyses). As an applicant, you will be solely responsible for planning, directing, and executing the proposed project.
This funding opportunity uses just-in-time concepts. It also uses the modular as well as the non-modular budget formats (see https://grants.nih.gov/grants/funding/modular/modular.htm). Specifically, if you are submitting an application with direct costs in each year of $250,000 or less, use the modular budget format described in the PHS 398 application instructions. Otherwise follow the instructions for non-modular research grant applications.
Based on the particular science proposed and the determined need for substantial involvement by NIMH staff, NIMH may convert a linked set of collaborative R01s into cooperative agreement U01s or U10s, following the peer review.
2. Funds Available
The NIMH intends to commit approximately $3,000,000 to fund 5-7 new and/or competing continuation grants in response to this and the related announcement (RFA-MH-07-040). An applicant may request a project period of up to 5 years and a budget for direct costs up to $800,000 per year. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. Although the financial plans of the IC(s) provide support for this program, awards pursuant to this funding opportunity are contingent upon the availability of funds and the receipt of a sufficient number of meritorious applications. The anticipated start dates for new awards is April 1, 2007.
Facilities and administrative costs requested by
consortium participants are not included in the direct cost limitation, see NOT-OD-05-004.
Section III. Eligibility Information
1. Eligible Applicants
1.A. Eligible Institutions
You may submit (an) application(s) if your organization has any of the following characteristics:
1.B. Eligible Individuals
Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support.
2. Cost Sharing or Matching
Cost sharing is not required. The most current Grants Policy Statement can be found at: https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm#matching_or_cost_sharing
3. Other-Special Eligibility Criteria
Not applicable.
Section IV. Application and Submission Information
1. Address to Request Application Information
The PHS 398 application instructions are available at https://grants.nih.gov/grants/funding/phs398/phs398.html in an interactive format. Applicants must use the currently approved version of the PHS 398. For further assistance contact GrantsInfo, Telephone (301) 710-0267, Email: firstname.lastname@example.com.
Telecommunications for the hearing impaired: TTY 301-451-5936.
2. Content and Form of Application Submission
Applications must be prepared using the most current PHS 398 research grant application instructions and forms. Applications must have a D&B Data Universal Numbering System (DUNS) number as the universal identifier when applying for Federal grants or cooperative agreements. The D&B number can be obtained by calling (866) 705-5711 or through the web site at http://www.dnb.com/us/. The D&B number should be entered on line 11 of the face page of the PHS 398 form.
The title and number of this funding opportunity must be typed on line 2 of the face page of the application form and the YES box must be checked.
The application from each site must contain an identical OVERVIEW that is no longer than 2 pages. (This is in addition to the 25 page research plan (Sections A-D)). The overview should provide an overall rationale for applying as a collaborative study; the role of each site; the approach to project management; and elements unique to any of the sites.
The application from each site must contain an identical RESEARCH PLAN - Section 2, A - D. The research plan must describe those aspects of the project that are common to all sites of the collaboration. Investigators should use this section to describe the research procedures or protocol, the study population from which samples are drawn, resources, data analyses, and any other characteristics that support each site's importance to the overall project. All variations in the research plan between sites, no matter how minor, should be highlighted in a subsection of Section 2 D with the heading "ELEMENTS UNIQUE TO THIS SITE." In this subsection PIs should describe, for example, how the research site has a unique role in the collaboration, such as data coordination, statistical analyses, etc.
Applications must describe a feasible mechanism for scientific integration of research procedures, overall managerial and administrative responsibilities, and cross-site comparability of training to assure reliability and quality control. The PIs may or may not wish to designate a Steering Committee or other decision making body, or identify one individual as the contact person for the group as a whole, for purposes of NIMH correspondence. Plans for ensuring access to data by all sites, analytic resources, publication and authorship rights, the possibility of public use research materials and data, or other means of distributing research materials to the wider scientific community, and a means of arbitrating disagreements on publication and other issues should be included in the application.
Any site that contracts out some portions of this work should list this fact under "ELEMENTS UNIQUE TO EACH SITE," and provide a full description of the nature, purpose and oversight of this contractual arrangement.
Revised collaborative CSMD applications must include an Introduction, up to 3 pages, and highlight the changes made in the Research Plan in response to the previous critique. This introduction should also describe how the delay in initiating the collaboration will be managed. This is particularly important if some projects in the collaborative CSMD group were awarded and research on those projects has already begun.
Foreign Organizations
Several special provisions apply to applications submitted by foreign organizations:
Proposed research should provide special opportunities for furthering research programs through the use of unusual talent, resources, populations, or environmental conditions in other countries that are not readily available in the United States or that augment existing U.S. resources.
Submission Dates and Times
Applications must be received on or before the receipt date described below (Section IV.3.A).
3.A. Receipt, Review and Anticipated Start Dates
Letters of Intent Receipt Date(s): June 21, 2006
Application Receipt Dates(s): July 21, 2006
Peer Review Date(s): November/December 2006
Council Review Date(s): January 2007
Earliest Anticipated Start Date(s): April 2007
3.A.1. Letter of Intent
Prospective applicants are asked to submit a letter of intent that includes the following information:
Although a letter of intent is not required, is not binding, and does not enter into the review of a subsequent application, the information that it contains allows IC staff to estimate the potential review workload and plan the review.
The letter of intent is to be sent by the date listed at the beginning
of this document.
The letter of intent should be sent to:
Thomas Lehner, Ph.D., M.P.H.
Office of Human Genetics & Genomic Resources
Division of Neuroscience and Basic Behavioral Science
National Institute of Mental Health
6001 Executive Blvd, Room 7190, MSC 9643
Bethesda, MD 20892-9643
Telephone: (301) 443-1706
Email: email@example.com
3.B. Sending an Application to the NIH
Applications must be prepared using the research grant applications found in the PHS 398 instructions for preparing a research grant application. Submit a signed, typewritten original of the application, including the checklist, and three signed photocopies in one package to:
Center for Scientific Review
National Institutes of Health
6701 Rockledge Drive, Room 1040, MSC 7710
Bethesda, MD 20892-7710 (U.S. Postal Service Express or regular mail)
Bethesda, MD 20817 (for express/courier service; non-USPS service)
Personal deliveries of applications are no longer permitted (see https://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-040.html).
At the time of submission, two additional copies of the application and all copies of the appendix material must be sent to:
Shuang-Bao Hu, Ph.D.
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Blvd, Room 6156, MSC 9609
Bethesda, MD 20892-9609
Telephone: (301) 443-5160
Email: email@example.com
the RFA Label: The RFA label available in the PHS 398 application
instructions must be affixed to the bottom of the face page of the application.
Type the RFA number on the label. Failure to use this label could result in
delayed processing of the application such that it may not reach the review
committee in time for review. In addition, the RFA title and number must be
typed on line 2 of the face page of the application form and the YES box must
be marked. The RFA label is also available at: https://grants.nih.gov/grants/funding/phs398/labels.pdf.
3.C. Application Processing
Applications must be received on or before the application receipt date(s) described above (Section IV.3.A.). If an application is received after that date, it will be returned to the applicant without review. Upon receipt, applications will be evaluated for completeness by the CSR and responsiveness by the NIMH. Incomplete and non-responsive applications will not be reviewed. If the application is not responsive to the RFA, NIH staff may contact the applicant to determine whether to return the application to the applicant or submit it for review in competition with unsolicited applications at the next appropriate NIH review cycle.
The NIH will not accept any application in response to this funding opportunity that is essentially the same as one currently pending initial review, unless the applicant withdraws the pending application. However, when a previously unfunded application, originally submitted as an investigator-initiated application, is to be submitted in response to a funding opportunity, it is to be prepared as a NEW application. That is, the application for the funding opportunity must not include an Introduction describing the changes and improvements made, and the text must not be marked to indicate the changes from the previous unfunded version of the application.
Information on the status of an application should be checked by the Principal Investigator in the eRA Commons at: https://commons.era.nih.gov/commons/.
4. Intergovernmental Review
This initiative is not subject to intergovernmental review.
5. Funding Restrictions
All NIH awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The Grants Policy Statement can be found at https://grants.nih.gov/grants/policy/policy.htm.
Pre-Award Costs are allowable. A grantee may, at its own risk and without NIH prior approval, incur obligations and expenditures to cover costs up to 90 days before the beginning date of the initial budget period of a new or competing continuation award if such costs: are necessary to conduct the project, and would be allowable under the grant, if awarded, without NIH prior approval. If specific expenditures would otherwise require prior approval, the grantee must obtain NIH approval before incurring the cost. NIH prior approval is required for any costs to be incurred more than 90 days before the beginning date of the initial budget period of a new or competing continuation award.
The incurrence of pre-award costs in anticipation of a competing or non-competing award imposes no obligation on NIH either to make the award or to increase the amount of the approved budget if an award is made for less than the amount anticipated and is inadequate to cover the pre-award costs incurred. NIH expects the grantee to be fully aware that pre-award costs result in borrowing against future support and that such borrowing must not impair the grantee's ability to accomplish the project objectives in the approved time frame or in any way adversely affect the conduct of the project. See NIH Grants Policy Statement https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm.
6. Other Submission Requirements
As subcontracts and consortium arrangements may occur, please make note of the policy on Facilities and Administrative (F & A) costs for subcontracts/consortia. F&A costs requested by consortium participants are not included in the direct cost limitation, see NOT-OD-05-004.
Specific Instructions for Modular Grant applications.
Applications requesting up to $250,000 per year in direct costs must be submitted in a modular budget format. The modular budget format simplifies the preparation of the budget in these applications by limiting the level of budgetary detail. Applicants request direct costs in $25,000 modules. Section C of the research grant application instructions for the PHS 398 at https://grants.nih.gov/grants/funding/phs398/phs398.html includes step-by-step guidance for preparing modular budgets. Applicants must use the currently approved version of the PHS 398. Additional information on modular budgets is available at https://grants.nih.gov/grants/funding/modular/modular.htm.
Plan for Sharing Research Data
The precise content of the data-sharing plan will vary, depending on the data being collected and how the investigator is planning to share the data. Applicants who are planning to share data may wish to describe briefly the expected schedule for data sharing, the format of the final dataset, the documentation to be provided, whether or not any analytic tools also will be provided, whether or not a data-sharing agreement will be required and, if so, a brief description of such an agreement (including the criteria for deciding who can receive the data and whether or not any conditions will be placed on their use), and the mode of data sharing (e.g., under their own auspices by mailing a disk or posting data on their institutional or personal website, through a data archive or enclave). Investigators choosing to share under their own auspices may wish to enter into a data-sharing agreement. References to data sharing may also be appropriate in other sections of the application.
All applicants must include a plan for sharing research data in their application. The data sharing policy is available at https://grants.nih.gov/grants/policy/data_sharing. All investigators responding to this funding opportunity should include a description of how final research data will be shared, or explain why data sharing is not possible.
The sharing of biomaterials, data, and software in a timely manner has been an essential element in the rapid progress that has been made in the genetic analysis of human diseases. To address the joint interests of the government in the availability of, and access to, the results of publicly funded research and in the opportunity for economic development based on these results, NIH requires applicants who respond to this RFA to develop and propose detailed plans for data sharing. The dissemination of data via individual laboratories and Web sites is not sufficient, as it would force interested investigators to have to search several different data collections to make use of the results of this initiative. In addition, differences in protocols across projects for creating databases may make it impossible for researchers to combine information for integrated genetic analyses. It is preferable that data from subjects analyzed in grants funded under this PA should be placed in common repositories and databases that are widely accessible by investigators in the international scientific community. An NIMH-supported data management facility and cell repository – the NIMH Center for Collaborative Genetic Studies on Mental Disorders (http://nimhgenetics.org) - is such a community resource.
The reasonableness of the data sharing plan or the rationale for not
sharing research data may be assessed by the reviewers. However, reviewers will
not factor the proposed data sharing plan into the determination of scientific
merit or the priority score.
Sharing Research Resources
NIH policy requires that grant awardee recipients make unique research resources readily available for research purposes to qualified individuals within the scientific community after publication (NIH Grants Policy Statement https://grants.nih.gov/archive/archive/grants/policy/nihgps_2003/index.htm and https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm#_Toc54600131). Investigators responding to this funding opportunity should include a plan for sharing research resources addressing how unique research resources will be shared or explain why sharing is not possible.
The adequacy of the resources sharing plan and any related data sharing plans will be considered by Program staff of the funding organization when making recommendations about funding applications. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each non-competing Grant Progress Report (PHS 2590, https://grants.nih.gov/grants/funding/2590/2590.htm). See Section VI.3. Reporting.
Section V. Application Review Information
1. Criteria
Only the review criteria described below will be considered in the review process.
The following will be considered in making funding decisions:
2. Review
and Selection Process
Applications that are complete and responsive to the RFA will be evaluated for scientific and technical merit by an appropriate peer review group convened by the NIMH in accordance with the review criteria stated below.
As part of the initial merit review, all applications will:
The goals of NIH supported research are to advance our understanding of biological systems, to improve the control of disease, and to enhance health. In their written critiques, reviewers will be asked to comment on each of the following criteria in order to judge the likelihood that the proposed research will have a substantial impact on the pursuit of these goals. Each of these criteria will be addressed and considered in assigning the overall score, weighting them as appropriate for each application. Note that an application does not need to be strong in all categories to be judged likely to have major scientific impact and thus deserve a high priority score. For example, an investigator may propose to carry out important work that by its nature is not innovative but is essential to move a field forward.
Significance: Does this study address an important problem? If the aims of the application are achieved, how will scientific knowledge or clinical practice be advanced? What will be the effect of these studies on the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field?
Approach: Are the conceptual or clinical framework, design, methods, and analyses adequately developed, well integrated, well reasoned, and appropriate to the aims of the project? Does the applicant acknowledge potential problem areas and consider alternative tactics?
Innovation: Is the project original and innovative? For example: Does the project challenge existing paradigms or clinical practice; address an innovative hypothesis or critical barrier to progress in the field? Does the project develop or employ novel concepts, approaches, methodologies, tools, or technologies for this area?
Investigators: Are the investigators appropriately trained and well suited to carry out this work? Is the work proposed appropriate to the experience level of the principal investigator and other researchers? Does the investigative team bring complementary and integrated expertise to the project (if applicable)?
Environment: Does the scientific environment in which the work will be done contribute to the probability of success? Do the proposed studies benefit from unique features of the scientific environment, or subject populations, or employ useful collaborative arrangements? Is there evidence of institutional support?
2.A. Additional Review Criteria:
In addition to the above criteria, the following items will continue to be considered in the determination of scientific merit and the priority score:
Collaboration: Are sufficient and feasible mechanisms in place to ensure collaboration across sites to achieve scientific integration of research procedures, overall managerial and administrative responsibilities, appropriate quality control and reliability assurance, and planning for data management, analysis and reporting of results? Are there adequate plans for shared decision making among PIs with regard to personnel, clinical decisions, changes in study protocol, and authorship?
of Human Subjects from Research Risk: The involvement of human subjects and protections from
research risk relating to their participation in the proposed research will be
assessed (see the Research Plan, Section E on Human Subjects in the PHS Form
Inclusion of Women, Minorities and Children in Research: The adequacy of plans to include subjects from both genders, all racial and ethnic groups (and subgroups), and children as appropriate for the scientific goals of the research will be assessed. Plans for the recruitment and retention of subjects will also be evaluated (see the Research Plan, Section E on Human Subjects in the PHS Form 398).
Care and Use of Vertebrate Animals in Research: If vertebrate animals are to be used in the project, the five items described under Section F of the PHS Form 398 research grant application instructions will be assessed.
Biohazards: If materials or procedures are proposed that are potentially hazardous to research personnel and/or the environment, determine if the proposed protection is adequate.
2.B. Additional Review Considerations
Budget: The reasonableness of the proposed budget and the requested period of support in relation to the proposed research. The priority score should not be affected by the evaluation of the budget.
2.C. Sharing Research Data
Data Sharing Plan: The reasonableness of the data sharing plan or the rationale for not sharing research data will be assessed by the reviewers. However, reviewers will not factor the proposed data sharing plan into the determination of scientific merit or the priority score. The presence of a data sharing plan will be part of the terms and conditions of the award. The funding organization will be responsible for monitoring the data sharing policy.
2.D. Sharing Research Resources
NIH policy requires that grant awardee recipients make unique research resources readily available for research purposes to qualified individuals within the scientific community after publication (See the NIH Grants Policy Statement https://grants.nih.gov/archive/grants/policy/nihgps/part_ii_5.htm#availofrr and
http://www.ott.nih.gov/policy/rt_guide_final.html). Investigators responding to
this funding opportunity should include a sharing research resources plan
addressing how unique research resources will be shared or explain why sharing
is not possible.
Program staff will be responsible for the administrative review of the plan for sharing research resources.
The adequacy of the resources sharing plan will be considered by Program staff of the funding organization when making recommendations about funding applications. Program staff may negotiate modifications of the data and resource sharing plans with the awardee before recommending funding of an application. The final version of the data and resource sharing plans negotiated by both will become a condition of the award of the grant. The effectiveness of the resource sharing will be evaluated as part of the administrative review of each non-competing Grant Progress Report (PHS 2590). See Section VI.3. Reporting.
3. Anticipated Announcement and Award Dates
The earliest start date will be April 1, 2007.
Section VI. Award Administration Information
1. Award Notices
After the peer review of the application is completed, the PD/PI will be able to access his or her Summary Statement (written critique) via the eRA Commons.
If the application is under consideration for funding,
NIH will request "just-in-time" information from the applicant. For
details, applicants may refer to the NIH Grants Policy Statement Part II: Terms
and Conditions of NIH Grant Awards, Subpart A: General (https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm).
A formal notification in the form of a Notice of Award (NoA) will be provided to the applicant organization. The NoA signed by the grants management officer is the authorizing document. Once all administrative and programmatic issues have been resolved, the NoA will be generated via email notification from the awarding component to the grantee business official (designated in item 12 on the Application Face Page). If a grantee is not email enabled, a hard copy of the NoA will be mailed to the business official.
Selection of an application for award is not an authorization to begin performance. Any costs incurred before receipt of the NoA are at the recipient's risk. These costs may be reimbursed only to the extent considered allowable pre-award costs. See Also Section IV.5. Funding Restrictions.
2. Administrative and National Policy Requirements
All NIH grant and cooperative agreement awards include the NIH Grants Policy Statement as part of the NoA. For these terms of award, see the NIH Grants Policy Statement Part II: Terms and Conditions of NIH Grant Awards, Subpart A: General (https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm) and Part II Terms and Conditions of NIH Grant Awards, Subpart B: Terms and Conditions for Specific Types of Grants, Grantees, and Activities (https://grants.nih.gov/archive/grants/policy/nihgps_2003/index.htm).
3. Reporting
Awardees will be required to submit the PHS Non-Competing Grant Progress Report, Form 2590 annually (https://grants.nih.gov/grants/funding/2590/2590.htm) and financial statements as required in the NIH Grants Policy Statement.
Section VII. Agency Contacts
We encourage your inquiries concerning this funding
opportunity and welcome the opportunity to answer questions from potential
applicants. Inquiries may fall into three areas: scientific/research, peer
review, and financial or grants management issues:
1. Scientific/Research Contacts:
Thomas Lehner, Ph.D., M.P.H.
Office of Human Genetics & Genomic Resources
Division of Neuroscience and Basic Behavioral Science
National Institute of Mental Health
6001 Executive Blvd, Room 7190, MSC 9643
Bethesda, MD 20892-9643
Telephone: (301) 443-1706
Email: firstname.lastname@example.com
2. Peer Review Contacts:
David Armstrong, Ph.D.
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6138, MSC 9606
Bethesda, MD 20892-9606
Telephone: (301) 443-3534
Email: email@example.com
3. Financial or Grants Management Contacts:
Dawn Walker
Division of Extramural Activities
National Institute of Mental Health
6001 Executive Boulevard, Room 6115, MSC 9605
Bethesda, MD 20892-9605
Telephone: (301) 443-3858
Email: email@example.com
Section VIII. Other Information
Required Federal Citations
Use of Animals in Research:
Recipients of PHS support for activities involving live, vertebrate animals must comply with PHS Policy on Humane Care and Use of Laboratory Animals (https://grants.nih.gov/grants/olaw/references/PHSPolicyLabAnimals.pdf) as mandated by the Health Research Extension Act of 1985 (https://grants.nih.gov/grants/olaw/references/hrea1985.htm), and the USDA Animal Welfare Regulations (http://www.nal.usda.gov/awic/legislat/usdaleg1.htm) as applicable.
Human Subjects Protection:
Federal regulations (45CFR46) require that applications and proposals involving human subjects must be evaluated with reference to the risks to the subjects, the adequacy of protection against these risks, the potential benefits of the research to the subjects and others, and the importance of the knowledge gained or to be gained (http://www.hhs.gov/ohrp/humansubjects/guidance/45cfr46.htm).
Data and Safety Monitoring Plan:
Data and safety monitoring is required for all types of clinical trials, including physiologic toxicity and dose-finding studies (phase I); efficacy studies (Phase II); efficacy, effectiveness and comparative trials (Phase III). Monitoring should be commensurate with risk. The establishment of data and safety monitoring boards (DSMBs) is required for multi-site clinical trials involving interventions that entail potential risks to the participants (NIH Policy for Data and Safety Monitoring, NIH Guide for Grants and Contracts, https://grants.nih.gov/grants/guide/notice-files/not98-084.html).
Sharing Research Data:
Investigators submitting an NIH application seeking $500,000 or more in direct costs in any single year are expected to include a plan for data sharing or state why this is not possible (https://grants.nih.gov/grants/policy/data_sharing).
Investigators should seek guidance from their institutions, on issues related to institutional policies and local IRB rules, as well as local, State and Federal laws and regulations, including the Privacy Rule. Reviewers will consider the data sharing plan but will not factor the plan into the determination of the scientific merit or the priority score.
Access to Research Data through the Freedom of Information Act:
The Office of Management and Budget (OMB) Circular A-110 has been revised to provide access to research data through the Freedom of Information Act (FOIA) under some circumstances. Data that are (1) first produced in a project that is supported in whole or in part with Federal funds and (2) cited publicly and officially by a Federal agency in support of an action that has the force and effect of law (i.e., a regulation) may be accessed through FOIA. It is important for applicants to understand the basic scope of this amendment. NIH has provided guidance at https://grants.nih.gov/grants/policy/a110/a110_guidance_dec1999.htm. Applicants may wish to place data collected under this funding opportunity in a public archive, which can provide protections for the data and manage the distribution for an indefinite period of time. If so, the application should include a description of the archiving plan in the study design and include information about this in the budget justification section of the application. In addition, applicants should think about how to structure informed consent statements and other human subjects procedures given the potential for wider use of data collected under this award.
Sharing of Model Organisms:
NIH is committed to support efforts that encourage sharing of important research resources including the sharing of model organisms for biomedical research (see https://grants.nih.gov/grants/policy/model_organism/index.htm). At the same time the NIH recognizes the rights of grantees and contractors to elect and retain title to subject inventions developed with Federal funding pursuant to the Bayh Dole Act (see the NIH Grants Policy Statement https://grants.nih.gov/archive/archive/grants/policy/nihgps_2003/index.htm). All investigators submitting an NIH application or contract proposal, beginning with the October 1, 2004 receipt date, are expected to include in the application/proposal a description of a specific plan for sharing and distributing unique model organism research resources generated using NIH funding or state why such sharing is restricted or not possible. This will permit other researchers to benefit from the resources developed with public funding. The inclusion of a model organism sharing plan is not subject to a cost threshold in any year and is expected to be included in all applications where the development of model organisms is anticipated.
Inclusion of Women And Minorities in Clinical Research:
It is the policy of the NIH that women and members of minority groups and their sub-populations must be included in all NIH-supported clinical research projects unless a clear and compelling justification is provided indicating that inclusion is inappropriate with respect to the health of the subjects or the purpose of the research. This policy results from the NIH Revitalization Act of 1993 (Section 492B of Public Law 103-43). All investigators proposing clinical research should read the "NIH Guidelines for Inclusion of Women and Minorities as Subjects in Clinical Research (https://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-001.html); a complete copy of the updated Guidelines is available at https://grants.nih.gov/grants/funding/women_min/guidelines_amended_10_2001.htm. The amended policy incorporates: the use of an NIH definition of clinical research; updated racial and ethnic categories in compliance with the new OMB standards; clarification of language governing NIH-defined Phase III clinical trials consistent with the new PHS Form 398; and updated roles and responsibilities of NIH staff and the extramural community. The policy continues to require for all NIH-defined Phase III clinical trials that: a) all applications or proposals and/or protocols must provide a description of plans to conduct analyses, as appropriate, to address differences by sex/gender and/or racial/ethnic groups, including subgroups if applicable; and b) investigators must report annual accrual and progress in conducting analyses, as appropriate, by sex/gender and/or racial/ethnic group differences.
Inclusion of Children as Participants in Clinical Research:
The NIH maintains a policy that children (i.e., individuals under the age of 21) must be included in all clinical research, conducted or supported by the NIH, unless there are scientific and ethical reasons not to include them.
All investigators proposing research involving human subjects should read the "NIH Policy and Guidelines" on the inclusion of children as participants in research involving human subjects (https://grants.nih.gov/grants/funding/children/children.htm).
Required Education on the Protection of Human Subject Participants:
NIH policy requires education on the protection of human subject participants for all investigators submitting NIH applications for research involving human subjects and individuals designated as key personnel. The policy is available at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
Human Embryonic Stem Cells (hESC):
Criteria for federal funding of research on hESCs can be found at http://stemcells.nih.gov/index.asp and at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-02-005.html. Only research using hESC lines that are registered in the NIH Human Embryonic Stem Cell Registry will be eligible for Federal funding (http://escr.nih.gov). It is the responsibility of the applicant to provide in the project description and elsewhere in the application as appropriate, the official NIH identifier(s) for the hESC line(s)to be used in the proposed research. Applications that do not provide this information will be returned without review.
NIH Public Access Policy:
NIH-funded investigators are requested to submit to the NIH manuscript submission (NIHMS) system (http://www.nihms.nih.gov) at PubMed Central (PMC) an electronic version of the author's final manuscript upon acceptance for publication, resulting from research supported in whole or in part with direct costs from NIH. The author's final manuscript is defined as the final version accepted for journal publication, and includes all modifications from the publishing peer review process.
NIH is requesting that authors submit manuscripts resulting from 1) currently funded NIH research projects or 2) previously supported NIH research projects if they are accepted for publication on or after May 2, 2005. The NIH Public Access Policy applies to all research grant and career development award mechanisms, cooperative agreements, contracts, Institutional and Individual Ruth L. Kirschstein National Research Service Awards, as well as NIH intramural research studies. The Policy applies to peer-reviewed, original research publications that have been supported in whole or in part with direct costs from NIH, but it does not apply to book chapters, editorials, reviews, or conference proceedings. Publications resulting from non-NIH-supported research projects should not be submitted.
For more information about the Policy or the submission process please visit the NIH Public Access Policy Web site at http://publicaccess.nih.gov/ and view the Policy or other Resources and Tools including the Authors' Manual (http://publicaccess.nih.gov/publicaccess_Manual.htm).
Standards for Privacy of Individually Identifiable Health Information:
The Department of Health and Human Services (DHHS) issued final modification to the "Standards for Privacy of Individually Identifiable Health Information", the "Privacy Rule", on August 14, 2002 . The Privacy Rule is a federal regulation under the Health Insurance Portability and Accountability Act (HIPAA) of 1996 that governs the protection of individually identifiable health information, and is administered and enforced by the DHHS Office for Civil Rights (OCR).
Decisions about applicability and implementation of the Privacy Rule reside with the researcher and his/her institution. The OCR website (http://www.hhs.gov/ocr/) provides information on the Privacy Rule, including a complete Regulation Text and a set of decision tools on "Am I a covered entity?" Information on the impact of the HIPAA Privacy Rule on NIH processes involving the review, funding, and progress monitoring of grants, cooperative agreements, and research contracts can be found at https://grants.nih.gov/grants/guide/notice-files/NOT-OD-03-025.html.
URLs in NIH Grant Applications or Appendices:
All applications and proposals for NIH funding must be self-contained within specified page limitations. Unless otherwise specified in an NIH solicitation, Internet addresses (URLs) should not be used to provide information necessary to the review because reviewers are under no obligation to view the Internet sites. Furthermore, we caution reviewers that their anonymity may be compromised when they directly access an Internet site.
Healthy People 2010:
The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2010," a PHS-led national activity for setting priority areas. This PA is related to one or more of the priority areas. Potential applicants may obtain a copy of "Healthy People 2010" at http://www.health.gov/healthypeople.
Authority and Regulations:
This program is described in the Catalog of Federal Domestic Assistance at http://www.cfda.gov/ and is not subject to the intergovernmental review requirements of Executive Order 12372 or Health Systems Agency review. Awards are made under the authorization of Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR 52 and 45 CFR Parts 74 and 92. All awards are subject to the terms and conditions, cost principles, and other considerations described in the NIH Grants Policy Statement. The NIH Grants Policy Statement can be found at https://grants.nih.gov/grants/policy/policy.htm
The PHS strongly encourages all grant recipients to provide a smoke-free workplace and discourage the use of all tobacco products. In addition, Public Law 103-227, the Pro-Children Act of 1994, prohibits smoking in certain facilities (or in some cases, any portion of a facility) in which regular or routine education, library, day care, health care, or early childhood development services are provided to children. This is consistent with the PHS mission to protect and advance the physical and mental health of the American people.
Loan Repayment Programs:
NIH encourages applications for educational loan repayment from qualified health professionals who have made a commitment to pursue a research career involving clinical, pediatric, contraception, infertility, and health disparities related areas. The LRP is an important component of NIH's efforts to recruit and retain the next generation of researchers by providing the means for developing a research career unfettered by the burden of student loan debt. Note that an NIH grant is not required for eligibility and concurrent career award and LRP applications are encouraged. The periods of career award and LRP award may overlap providing the LRP recipient with the required commitment of time and effort, as LRP awardees must commit at least 50% of their time (at least 20 hours per week based on a 40 hour week) for two years to the research. For further information, please see: http://www.lrp.nih.gov.
Weekly TOC for this Announcement
NIH Funding Opportunities and Notices
Office of Extramural
Research (OER)
National Institutes of Health (NIH)
9000 Rockville Pike
Bethesda, Maryland 20892
Department of Health
and Human Services (HHS)
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"Now That You're Gone" is the name of a song on Sheryl Crow's newest album. It's about a guy. Nearly a year following their last confrontation, she confesses to "shaking even talking about it again," according to the latest Rolling Stone. "I feel like I got his stink on me." Oooooooh, who's it about? Not telling till you click the pic!
Ha ha! Not Lance! It's about Karl Rove. Remember their creepy confrontation at last year's White House Correspondents Dinner? I'd totally forgotten about it. But Sheryl sure hasn't! Her latest album, Detours, also includes a song for the Chief Turd's old boss inspired by the Valerie Plame thing! She calls the album "urgent, in-your-face, barf-it-out-onto-a-page." It's her first collaboration with producer Bill Bottrell since Tuesday Night Music Club, which featured the last Sheryl Crow song I didn't feel slightly guilty for liking. (The last Sheryl Crow song I do feel guilty for liking: My Favorite Mistake.)

subset: commoncrawl


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http://moviesblog.mtv.com/2011/06/24/game-of-thrones-season-2-casting/This sorta ticks me off. out of all the casting choices they make public first, it's Margaery Tyrell? I want my Onion Knight! Though she was hot on the Tudors...
out of all the casting choices they make public first, it's Margaery Tyrell?
She starts small, yes, but grows up!
Thankfully, "A Variety of Violins" is not the newly announced title for the next volume in George R.R. Martin's A Song of Ice and Fire. It's just my cutesy why of describing this wonderful all-violin rendition of the Game of Thrones theme by Jason Yang. You know, HBO, if you assembled all these awesome GoT covers into one album, I'd buy the shit out of it. Just sayin'.
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Spring begins on Wednesday with showers & cool temperatures
A cloudy start to Spring for the Southeast
Spring begins this year under mostly cloudy skies with dropping temperatures during the day. A low pressure development along a cold front brings chances for showers also. Average Highs for March 19th for Jacksonville reach 74° while average lows dip to 50°. Jacksonville typically gets 0.12" of rain on the first day of Spring as well.
The high temperature for Wednesday may very well be reached during the morning hours, as chilly Northwesterly winds may be sustained as high as 15mph, with gusts of up to 23mph. Cloudy skies are expected, and temperatures may only be as warm as the mid to upper 60's, and then drop into the 50's by the afternoon hours as cooler air continues to flow into our area.
Scattered chances for passing showers are expected as well. Expect 60% coverage of showers in the Jacksonville area. Rainfall amounts across Northeast Florida are expected to range between a quarter of an inch and half an inch. Some isolated areas may see up to an inch of rain. Southeast Georgia is expected to receive a quarter of an inch or less of rain on Wednesday. The rain should end abruptly by midnight Wednesday night.
Early Thursday morning the skies clear as much cooler air rushed into the Southeast. Temperatures will dip into the mid to upper 30's early Thursday morning. No frost is expected due to gusty, strong winds. Those same winds will prompt wind chill temperatures close to freezing by sunrise. Expect a much cooler than average Thursday with clear skies, no chance for rain, and high temperatures struggling to reach the mid 60's.
Thursday evening. the cooler trend continues, and deepens. Overnight lows early Friday morning dip to the mid to low 30's, and frost is possible, primarily for inland locations.
Friday, expect partly cloudy skies and temperatures reaching the upper 60's for afternoon highs. Clouds return Friday night ahead of significant chances for rain over the weekend and cool temperatures.
Copyright 2013 by News4Jax.com. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.


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One jacket, two sides: Lightweight has developed a jacket that will make your way around town as functional as possible for it meets all the demands of both worlds: sports and style. A noble look combined with a whole set of technical features. In just a few easy steps you can transform the plain functional jacket into a smart business jacket.
The tape measure should be wrapped around the fullest part of the chest, the smallest part of the waist and the largest part of the hips. The entire circumference should be measured while the tape measure remains parallel to the ground. Heights comply with German standards (men with size 48/small – 180cm).
After taking measurements, the results are to be compared with the chart. If one is inbetween sizes the choice is free. All of the garments are slim fit and comply with German standards. If a more relaxed feel is preferred, the bigger sizeis recommended, but if one likes it tight, opting for the smaller sizeisbetter.


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ISO has appointed the Unicode Consortium as the Registration Authority for International Standard, Codes for the representation of names of scripts. Markus Scherer has been appointed Registrar by the Registration Authority.
The ISO 15924/RA receives and reviews applications for requesting new script codes and for the change of existing ones according to criteria indicated in the standard. It maintains an accurate list of information associated with registered script codes, processes updates of registered script codes, and distributes them on a regular basis to subscribers and other parties.
Additions and changes to approved script codes since the publication of ISO 15924:2004 appear in the script code lists and are also documented in the ISO 15924 Notice of Changes.
Proposals for additions and changes can be made with the request form.
If you have questions concerning ISO 15924 please contact us.
The Registrar can also be contacted by using the online contact form.
Additions to the ISO 15924 codes for scripts will be announced on the Unicode discussion list. Discussion about ISO 15924 and script codes is welcome on that list.


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Country Artists With Stars on the Hollywood Walk of Fame [PICTURES]
The iconic Hollywood Walk of Fame spans more than 15 blocks in Hollywood, Calif. The stars featured there, glittering in the sidewalks, honor the careers of entertainment industry greats -- yes, country stars included. The Hollywood Walk of Fame features everyone from actors to radio personalities, and there are plenty of Nashville names enshrined there.
One country artist has five stars to his name. In 2020, one will be one of the newest Hollywood Walk of Fame inductees.
There are four dozen country artists on the Walk of Fame in total. Flip through the photo gallery below to learn who they are, when they were inducted and where you can find their stars.


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COMSOL opens a new office in Curitiba to expand the use of COMSOL Multiphysics simulation software in Brazil
BURLINGTON, MA (February 3, 2014) – COMSOL, Inc., today announced the opening of a new office in Curitiba, Paraná, to provide multiphysics simulation and analysis software for the Brazilian market. By establishing direct operations in Brazil, COMSOL can fully serve the region's vibrant high-tech industry and research community. Users of the company's flagship product – COMSOL Multiphysics – will benefit from local technical support, comprehensive training sessions, and opportunities for on-site seminars and company visits.
Today, many leading firms in the automotive, chemical processing, and equipment manufacturing industries in Brazil have adopted COMSOL Multiphysics as their tool for product development. "Brazil is home to engineers, researchers, and entrepreneurs who are at the forefront of technical innovations and developments around the world," says Alisson Roman, Managing Director of COMSOL Ltda. "This new COMSOL office will provide multiphysics modeling software and technical support for our customers to successfully apply simulation to their projects."
Customers of COMSOL are excited to have the company present in Brazil, and leading firms such as Siemens, Petrobras, and others have expressed their enthusiasm at the coming office in Curitiba. "It's going to be very good to have a COMSOL office in Brazil. We'll have local technical support and training from a simulation tool that we're very satisfied with," says Glauco Cangane, Research Manager at Siemens Development and Innovation in Brazil. "With the right technical and commercial approach, we believe that COMSOL will be as successful in Brazil as it has been worldwide."
Over the past decade, engineering research centers and industries in Brazil have been growing, demonstrating the need for access to a cutting-edge computer aided engineering (CAE) software in this area. "Brazil is a big market with world-class science and engineering sectors. For these industries, multiphysics simulation software is a mission critical tool for efficient product development and innovation," says Svante Littmarck, President and CEO of COMSOL, Inc. "The new office in Curitiba is key to better serving our customers in Brazil and to increasing the use of COMSOL Multiphysics in this region."
About COMSOL
COMSOL provides simulation software for product design and research to technical enterprises, research labs, and universities through 20 offices and a distributor network throughout the world. Its flagship product, COMSOL Multiphysics®, is a software environment for modeling and simulating any physics-based system. A particular strength is its ability to account for coupled or multiphysics phenomena. Add-on products expand the simulation platform for electrical, mechanical, fluid flow, and chemical applications. Interfacing tools enable the integration of COMSOL Multiphysics® simulation with all major technical computing and CAD tools on the CAE market.
COMSOL, COMSOL Multiphysics, Capture the Concept, COMSOL Desktop, and LiveLink are either registered trademarks or trademarks of COMSOL AB. All other trademarks are the property of their respective owners, and COMSOL AB and its subsidiaries and products are not affiliated with, endorsed by, sponsored by, or supported by those trademark owners. For a list of such trademark owners, see www.comsol.com/trademarks
COMSOL, Inc.
1 New England Executive Park,
Ste 350
Burlington, MA 01803 USA
Phone: +1 781-273-3322
Web: www.comsol.com
COMSOL Ltda.
Avenida Comendador Franco, 1341
Curitiba, PR
Phone: +55 41 3156 9100
Web: www.br.comsol.com
Media Contact: Alisson Roman, Email Contact\


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Industrial refrigeration
Cutting energy consumption to cut costs
SKF can make it happenDrawing on many years of experience working with compressor OEMs and end-users, SKF can offer a range of solutions to meet specific compressor efficiency requirements.
For twin screw compressors, for example, we can recommend the optimum bearing arrangements and materials to handle the refrigerants and lubricants involved. We can help upgrade reciprocating units and designs with solutions that compensate for their high operating temperatures. And we can help OEMs move away from traditionally complex centrifugal compressor designs toward those that eliminate the use of oil as a lubricant.


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Frequently Asked Questions - Civilian Personnel Records
- How do I get information from my civilian personnel records? Read more...
- Where can I get information regarding retirement benefits for former Federal civilian employees? Read more...
- I want to be reinstated into Federal service. What forms do I need? Read more...
- Where can I call for help or immediate assistance? Read more...
- Is the NPRC open to public visitors? Read more...
- What records would be useful for genealogical research? Read more...
1. How do I get information from my civilian personnel records?
|For Federal civil servant whose employment ended before 1952
|For the Federal civil servant whose employment ended after 1951
Civilian personnel records are normally transferred to the National Personnel Records Center within 120 days after an employee's separation from Federal employment. If less than 120 days have elapsed since separation, write to the last employing office. Thereafter, send your request to the address listed below.
Certain basic information needed to locate civilian personnel records, includes:
- full name used during Federal employment,
- date of birth,
- Social Security Number (if applicable),
- name and location of employing Federal agency,
- beginning and ending dates of Federal service
Contact Information: click the links above for mailing and contact numbers.
2. Where can I get information regarding retirement benefits for former Federal civilian employees?
The information requested is not on file at the National Personnel Records Center. Questions relating to retirement and benefits should be directed to:
U.S. Office of Personnel Management
Retirement Operations Center
Post Office Box 45
Boyers, PA 16017
3. I want to be reinstated into Federal service. What forms do I need?
Copies of Standard Form 50 (Personnel Action) from your previous Federal employment are usually needed for reinstatement purposes. You may request copies of those documents by writing to the National Personnel Records Center. The NPRC does not have the authority to determine reinstatement eligibility, only the Office of Personnel Management (OPM) or the hiring agency can determine that.
Contact the personnel office with which you are currently employed or seeking employment, or:
U. S. Office of Personnel Management
Employment Service
1900 E Street, NW
Washington, DC 20415
4. Where can I call for help or immediate assistance?
- National Personnel Records Center:
Telephone: 314-801-0800
Fax: 314-801-9195
E-mail: firstname.lastname@example.com
Status Check: email@example.com
- For other veterans-related questions:
- Department of Veterans Affairs:
Telephone: 1-800-827-1000
- Department of Veterans Affairs:
- For general inquiries, please call us toll free at:
- 1-866-272-6272 or 1-86-NARA-NARA
TDD lines: For College Park, MD: 301-837-0482
Fax: 301-837-0483
- 1-866-272-6272 or 1-86-NARA-NARA
5. Is the NPRC open to public visitors?
Individuals who wish to visit the NPRC because they have a strong interest in viewing records in person may request an appointment in the NPRC's Research Rooms: the Archival Research Room and/or the Federal Records Center Research Room (see Visitors and On-Site Researchers for additional information).
6. What records would be useful for genealogical research?
For Military Personnel Records: military service records, military pension records and bounty land warrant application files would all be useful. Please visit Genealogy Research in Military Records for additional information.
For Civilian Personnel Records: If your family member was employed by the Federal Government, the Official Personnel Folder (OPF) would be a primary source for research.
See Records Location Table for contact information
* Please see our Privacy Statement
"NARA ensures, for the Citizen and the Public Servant, for the President and the Congress and the Courts, ready access to essential evidence."


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(New York, NY ) — Researchers at Columbia University Medical Center (CUMC) have identified a molecular pathway that controls the retention and release of the brain's stem cells. The discovery offers new insights into normal and abnormal neurologic development and could eventually lead to regenerative therapies for neurologic disease and injury. The findings, from a collaborative effort of the laboratories of Drs. Anna Lasorella and Antonio Iavarone, were published today in the online edition of Nature Cell Biology.
The research builds on recent studies, which showed that stem cells reside in specialized niches, or microenvironments, that support and maintain them.
"From this research, we knew that when stem cells detach from their niche, they lose their identity as stem cells and begin to differentiate into specific cell types," said co-senior author Antonio Iavarone, MD, professor of Pathology and Neurology at CUMC.
"However, the pathways that regulate the interaction of stem cells with their niche were obscure," said co-senior author Anna Lasorella, MD, associate professor of Pathology and Pediatrics at CUMC and a member of the Columbia Stem Cell Initiative.
In the brain, the stem cell niche is located in an area adjacent to the ventricles, the fluid-filled spaces within the brain. Neural stem cells (NSCs) within the niche are carefully regulated, so that enough cells are released to populate specific brain areas, while a sufficient supply is kept in reserve.
In previous studies, Drs. Iavarone and Lasorella focused on molecules called Id (inhibitor of differentiation) proteins, which regulate various stem cell properties. They undertook the present study to determine how Id proteins maintain stem cell identity.
Neural stem cells detaching from the vascular niche Image credit: Anna Lasorella, CUMC /Nature Cell Biology
The team developed a genetically altered strain of mice in which Id proteins were silenced, or knocked down, in NSCs. In the absence of Id proteins, mice died within 24 hours of birth. Their brains showed markedly lowered NSC proliferative capacity, and their stem cell populations were reduced.
Studies of NSCs from this strain of mice revealed that Id proteins directly regulate the production of a protein called Rap1GAP, which in turn controls Rap1, one of the master regulators of cell adhesion. The researchers found that the Id-Rap1GAP-Rap1 pathway is critical for the adhesion of NSCs to their niche and for NSC maintenance. "There may be other pathways involved, but we believe this is the key pathway," said Dr. Iavarone. "There is good reason to believe that it operates in other kinds of stem cells, and our labs are investigating this question now."
"This is a new idea," added Dr. Lasorella. "Before this study, the prevailing wisdom was that NSCs are regulated by the niche components, conceivably through the release of chemical attractants such as cytokines. However, our findings suggest that stem cell identity relies on this mechanism."
More research needs to be done before the findings can be applied therapeutically, Dr. Iavarone said. "Multiple studies show that NSCs respond to insults such as ischemic stroke or neurodegenerative diseases. If we can understand how to manipulate the pathways that determine stem cell fate, in the future we may be able to control NSC properties for therapeutic purposes."
"Another aspect," added Dr. Lasorella, "is to determine whether Id proteins also maintain stem cell properties in cancer stem cells in the brain. In fact, normal stem cells and cancer stem cells share properties and functions. Since cancer stem cells are difficult to treat, identifying these pathways may lead to more effective therapies for malignant brain tumors."
Stephen G. Emerson, MD, PhD, director of the Herbert Irving Comprehensive Cancer Center at NewYork-Presbyterian Hospital/Columbia University Medical Center, added that, "Understanding the pathway that allows stem cells to develop into mature cells could eventually lead to more effective, less toxic cancer treatments. This beautiful study opens up a wholly unanticipated way to think about treating brain tumors."
The paper is titled "Id proteins synchronize stemness and anchorage to the niche of neural stem cells." Other contributors are Francesco Niola (CUMC), Xudong Zhao (CUMC), Devendra Singh (CUMC), Angelica Castano (CUMC), Ryan Sullivan (CUMC), Mario Lauria (Telethon Institute of Genetics and Medicine, Naples, Italy), Hyung-song Nam (Memorial Sloan-Kettering Cancer Center, New York),, Yuan Zhuang (Duke University Medical Center, Durham, North Carolina), Robert Benezra (Memorial Sloan-Kettering), and Diego Di Bernardo (Telethon Institute of Genetics and Medicine).
This research was supported by National Cancer Institute grants R01CA101644, R01CA131126, R01CA085628, and R01CA127643, and National Institute of Neurological Disorders and Stroke grant R01NS061776.
The authors declare no financial or other conflicts of interest.
Columbia University Medical Center provides international leadership in basic, pre-clinical and clinical research, in medical and health sciences education, and in patient care. The medical center trains future leaders and includes the dedicated work of many physicians, scientists, public health professionals, dentists, and nurses at the College of Physicians and Surgeons, the Mailman School of Public Health, the College of Dental Medicine, the School of Nursing, the biomedical departments of the Graduate School of Arts and Sciences, and allied research centers and institutions. Established in 1767, Columbia's College of Physicians and Surgeons was the first institution in the country to grant the M.D. degree and is among the most selective medical schools in the country. Columbia University Medical Center is home to the largest medical research enterprise in New York City and State and one of the largest in the United States.
Media Contact:
Karin Eskenazi


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IXC necesitaba un nuevo diseño de logotipo y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 147 diseños de 27 diseñadores freelance.
IraqiXchange is an online portal connecting businesses and investors with a broad and dynamic network of people, news and information about Iraq. We are the leading source of intelligent market information.
Our mission is to raise awareness around the unique opportunity in Iraq. We believe that access to transparent information is the solution to attract investment capital, stimulate economic growth, and facilitate business dealings. We aspire to be a leading force in advocating free market development in Iraq by promoting transparency, connecting business leaders & fostering a culture of entrepreneurial innovation.
Businesses and investors in North America, Europe, GCC (Gulf Countries - Saudi, UAE, Qatar...)
'Iraq means Business'
We require a logo to express our commitment of introducing Iraq to the global markets and facilitating the flow of information in/out of Iraq (hence exchange). Our website will look modern, transparent, and professional. Ideally, the logo will display the national Iraqi colors (white, red, black, and perhaps a touch of green..) It needs to be dynamic and sharp, yet simple, and modern.
Our brand name, iraqixchange.com, iraqiXchange.com, IraqiXchange.com, or any variations of that will be used on the logo. You should be creative and emphasize the 'X' in some way. It is also possible to incorporate our slogan 'Iraq means Business' if you think it will enhance it.
Winning Designer will also have the opportunity to work on our Web Design. Any and all questions welcomed!
Descubre cómo funciona un concurso de diseño u obtén más información sobre nuestros servicios de diseño de logo.


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- The Graphic Canon Vol #1
- Publisher: Seven Stories Press
- Written by: Russ Kick→
- Art By: Benjamin Frisch, Aidan Koch, Alessandro Bonaccorsi, Alex Eckman-Lawn, Alice Duke, Andrice Arp, Caroline Picard, Coleman Barks, Conor Hughes, Cortney Skinner, Dave Morice, Dayton Edmonds, Edie Fake, Ellen Lindner, Eric Johnson, Fred Van Lente, Gareth Hinds, Hunt Emerson, Huxley King, Ian Ball, Ian Pollock, Isabel Greenberg, J. T. Waldman, Josh Levitas, Julian Peters, Kevin Dixon Kent Dixon, Lisa Brown, Matt Wiegle, Maxx Kelly, Micah Farritor, Michael Green, Michael Lagocki, Michael Stanyer, Molly Crabapple, Molly Kiely, Neil Patrick Pfarr, Omaha Perez, Peter Kuper, Rebecca Dart, Rick Geary, Robert Crumb, Robert Gregory, Ryan Dunlavey, Sanya Glisic, Seymour Chwast, Sharon Rudahl, Shawn Cheng, Stan Shaw, Tori McKenna, Two Fine Chaps, Valerie Schrag, Vicki Nerino, WillEisner, Yeji Yun, Yien Yip→
- Digital Release Date:
September 30th, 2015
- Language: English
THE GRAPHIC CANON (Seven Stories Press) is a gorgeous, one-of-a-kind trilogy that brings classic literatures of the world together with legendary graphic artists and illustrators. There are more than 130 illustrators represented and 190 literary works over three volumes--many newly commissioned, some hard to find--reinterpreted here for readers and collectors of all ages. Volume 1 takes us on a visual tour from the earliest literature through the end of the 1700s. Along the way, we're treated to eye-popping renditions of the human race's greatest epics: Gilgamesh, The Iliad, The Odyssey (in watercolors by Gareth Hinds), The Aeneid, Beowulf, and The Arabian Nights, plus later epics The Divine Comedy and The Canterbury Tales (both by legendary illustrator and graphic designer Seymour Chwast), Paradise Lost, and Le Morte D'Arthur. Two of ancient Greece's greatest plays are adapted--the tragedy Medea by Euripides and Tania Schrag's uninhibited rendering of the very bawdy comedy Lysistrata by Aristophanes (the text of which is still censored in many textbooks). Also included is Robert Crumb's rarely-seen adaptation of James Boswell's London Journal, filled with philosophical debate and lowbrow debauchery. Religious literature is well-covered and well-illustrated, with the Books of Daniel and Esther from the Old Testament, Rick Geary's awe-inspiring new rendition of the Book of Revelation from the New Testament, the Tao te Ching, Rumi's Sufi poetry, Hinduism's Mahabharata, and the Mayan holy book Popol Vuh, illustrated by Roberta Gregory. The Eastern canon gets its due, with The Tale of Genji (the world's first novel, done in full-page illustrations reminiscent of Aubrey Beardsley), three poems from China's golden age of literature lovingly drawn by pioneering underground comics artist Sharon Rudahl, the Tibetan Book of the Dead, a Japanese Noh play, and other works from Asia. Two of Shakespeare's greatest plays (King Lear and A Midsummer Night's Dream) and two of his sonnets are here, as are Plato's Symposium, Gulliver's Travels, Candide, A Vindication of the Rights of Woman, Renaissance poetry of love and desire, and Don Quixote visualized by the legendary Will Eisner. Some unexpected twists in this volume include a Native American folktale, an Incan play, Sappho's poetic fragments, bawdy essays by Benjamin Franklin, the love letters of Abelard and Heloise, and the decadent French classic Dangerous Liaisons, as illustrated by Molly Crabapple.→ more
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Giant algae blooms thriving under thinning Arctic sea ice
CBC News (Canada)
June 12, 2012
Scientists surprised to find phytoplankton growing below ice layer
A group of U.S. scientists has discovered enormous blooms of algae growing in an area of the Arctic Ocean that they never thought could support the phytoplankton: below the sea ice.
The discovery was a shock because living organisms don't usually survive underneath the ice pack that covers parts of the Arctic Ocean for much of the year and blocks out the light needed to sustain life.
"First, we were thinking, 'This can't be. This can't be possible. There's no way this can be what it looks like,'" Kevin R. Arrigo, a biological oceanographer at Stanford University in California and lead author of the study, told CBCNews.ca. "Then the next thing was: 'Has anybody seen this before?'"
Arrigo and his colleagues had certainly never seen anything like it on past Arctic expeditions.
"Typically, what we find when we sample the ice is that occasionally, there's things inside the ice, but there's almost no biology below the ice," Arrigo explained in a separate interview on the website of the journal Science, where his team's findings were published last week...
...Two of Arrigo's main fellow algae researchers on the trip were Donald K. Perovich of the Cold Regions Research and Engineering Laboratory and Thayer School of Engineering at Dartmouth, both in New Hampshire; and Robert S. Pickart of the Woods Hole Oceanographic Institution in Massachusetts.
Arrigo was primarily in charge of analyzing the water column while Perovich oversaw sea ice operations and Pickart analyzed the data from a physical oceanographer's perspective.


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- Home
- Game
- Beatmania IIDX 5th Style
- Love Again Tonight ~For Melissa MIX~
Love Again Tonight ~For Melissa MIX~
Description: [Dance Dance Revolution 4th Mix] By Naoki feat. Paula Terry
By Naoki feat. Paula Terry
Oh, yeah
Can't believe you are here
It seems just like a dream
But when you look in my eyes
The love becomes so clear to me
It's been so long but now
You're right here, lying by my side
I know how you really feel
Baby, please never let me go
Baby, let's love, love, love again
And again tonight, everything's alright
Then, the two of us can remember sweet, sweet love
Love, love, love, love (Even loving makes me feel this way)
Love, love, love, love (Yes it's me, and I love you so)
Baby, let's love, love, love again and again
Tonight, all the night, make it right
Stay the whole night right through
Right here by my side
Love, love, love again and again
Tonight, make it feel so right
You, only you who knows how
To love me so right
Love again tonight..
Contributed by Angela Liu <[email protected]>
[Submit an English translation for this song]
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My Little Pony Ties
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MAYFLOWER — ExxonMobil Corp. demolished two homes Monday in a Mayflower neighborhood where thousands of gallons of oil spilled when a pipeline ruptured last spring.
MAYFLOWER — ExxonMobil Corp. demolished two homes Monday in a Mayflower neighborhood where thousands of gallons of oil spilled when a pipeline ruptured last spring.
The homes in the Northwoods Subdivision were never cleared for re-entry after the spill because oil permeated their foundations, said ExxonMobil spokesman Aaron Stryk.
Stryk said ExxonMobil purchased the homes and decided recently to demolish them to clear away the oil.
ExxonMobil's Pegasus pipeline burst March 29, spewing 210,000 gallons of crude and forcing dozens of residents from their homes. The company has since said a manufacturing defect caused the rupture.
Elected officials in the region and members of Arkansas' congressional delegation have pressed the company to release safety information about the pipeline and also have called on ExxonMobil to move the pipeline from the Lake Maumelle Watershed, which serves as the source of drinking water for more than 400,000 Central Arkansas residents.
Exxon purchased one of the homes that was demolished Monday from owner Charles Williams on Aug. 26 for $151,000, according to the Faulkner County assessor's website. Williams purchased the property in 2009 for $130,000. The house on the lot was built in 2006, according to assessor information.
The second home demolished Monday was purchased by Exxon Aug. 21 at a price slightly lower than the amount homeowners paid about a year before the oil spill.
According to records, Jose Modica and Daneshia Roberts-Modica bought the house in 2012 for $180,000, and it was bought by Exxon for $177,000. The house on that property was also built in 2006, according to records.
Since Exxon rolled out an extensive property purchase program for the entire Northwoods neighborhood in the month after the spill, the company has closed five deals, Stryk said. Not all five are among the 22 homes that were evacuated because of the oil spill.
He said the company is in negotiations with the owner of a third home that was never cleared for re-entry by the Arkansas Department of Environmental Quality and Mayflower Unified Command.
Stryk said there is oil under the property, which is on a slight incline above the two demolished homes, and nearer to the rupture site.
Assessor information shows the property is owned by Greg Doster, and was purchased in 2006 for $165,000.
Stryk said Exxon does not yet own the property and is talking with the owner about the "next step," which the spokesman said might not necessarily be to demolish the home.
At the demolition site Monday, Stryk said the company was performing air and seismic monitoring as a precaution.
He said the decision to demolish the two homes was determined to be the most effective and efficient way to remove contaminated soil. He said he did not have information about the depth of the excavation.
Stryk said new soil would be brought in and that the lots would be sodded and remain as green space.


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France's oldest city and leading port is where urban grit meets Mediterranean beaches and immigrants embrace Provençal traditions. A 2013 European Capital of Culture, it hasn't seen this much development since Napoleon III's nineteenth-century empire-enhancing schemes.
Revving up for its role as a culture hub for this year, Marseille has renovated existing museums and opened new cultural venues. The director of the festivities, Jean-François Chougnet, lets us in on the five new buildings set to change the face of the city.
From left to right…
MuCEM "Opening in the spring, this extension of a museum of Mediterranean civilizations is a concrete cubic web by Rudy Ricciotti. The large promenade is free to the public [Esplanade St-Jean]."
Villa Méditerranée "Next to the MuCEM, this is a place for lectures about local culture. Stefano Boeri's complex design is like a giant letter C, the bottom section of which is underwater [Esplanade St-Jean]."
J1 "The ferry terminus will house galleries, a bar, and event space. It's part of the port's and the city's gritty, unpretentious history. It's supposed to be temporary but may well become permanent [Pl. de la Joliette]."
Tour-Panorama at the Friche la Belle de Mai "Once an artists' squat, now an artists' co-op, it has a parallelepiped-shaped addition on the roof and a range of avant-garde shows [41 rue Jobin]."
FRAC "Kengo Kuma's new, glittering glass contemporary art center is for regional art; the collection includes established names and hot young artists like Raphaël Zarka and Katinka Bock [20 blvd. de Dunkerque]."
Once a poor man's stew (cooked by fishermen's wives with the day's unsold catch), it's now a sought-after specialty. Here's where to find the best traditional—and innovative—interpretations.
In a mini fishing village in the middle of the metropolis, chef Denis Blanc starts with fish broth, throws in the local catch (scorpion fish, John Dory, conger eel, weaver fish, gurnard) and potatoes, and adds croutons and garlicky rouille. His secret? "Flavorsome fresh fish. And time—it takes two hours" (140 Vallon des Auffes; 33-4-91-52-14-38; bouillabaisse, $60).
Provence's only three-Michelin-star chef, Gérald Passédat serves a three-part deconstruction that he says is like diving into the Mediterranean: "You have shellfish from rock pools—clams, mussels—sliced in a carpaccio. You dive deeper for five fishes in a saffrony broth. And you descend to eat two large fish, cooked slowly. It's natural, very marine" (Anse de Maldormé, Corniche J. F. Kennedy; 33-4-91-59-25-92; prix fixe, $217).
Three quarters of France's new Calanques National Park, designated in April 2012, lies within Marseille's city limits. But the park is more awesome than urban: Its dazzling white limestone fjords—known as calanques—drop dramatically into the sea. Here's how to experience it.
1 by boat The best way to see the cliffs is by setting off from the port (see "V is for Vieux-Port," page 30). Compagnies Maritimes Calanques et Château d'If's boats drop you at picnicking spots (33-4-91-33-03-29; 3-hour trip, $36 per person), and Bleu Evasion's catamarans have skippers and snorkels (33-6-34-13-74-22; 3-hour trip, from $65 per person).
2 by foot The GR 98 footpath crosses the park, but access is restricted in summer and fall. The easiest calanques to reach on foot are Sugiton (from Aix-Marseille University's Luminy campus) or Cassis (from the Port-Miou marina).
3 by table At Calanque de Sormiou, Le Lunch is known for grilled fish by the water (33-4-91-25-05-37; entrées from $52; open late March–early Oct.), or climb to shack/château Le Château de Sormiou for unbeatable terrace views (Route du Feu de la Calanque de Sormiou; 33-4-91-25-08-69; entrées from $58; open late March–early Oct.).
There's a chambre for every age of nostalgia, whether your taste tends to Louis XV or International Modernism.
Built: 1753 InterContinental Marseille–Hotel Dieu In April, the magnificent arcaded eighteenth-century Hotel Dieu reopens with 194 pared-down rooms and a vast terrace overlooking the Vieux-Port (33-4-91-01-39-74; doubles from $356).
Built: 1816 Grand Hôtel Beauvau Marseille Vieux Port Everyone from Chopin to Cocteau has stayed at this hotel, lately redone in Napoleon III style with Provençal fabrics and antique desks. Most rooms have port views (33-4-91-54-91-00; doubles from $151).
Built: 1952 Hôtel Le Corbusier Part of a radical apartment block, its spruced-up rooms retain Le Corbusier's ingenious design. There's an exciting young chef in the restaurant, and designer Ora Ito is opening a rooftop gallery (33-4-91-16-78-00; doubles from $91).
Built: 2012 Mama Shelter Marseille Design on a budget comes with a pastis bar, a resident DJ, and comfy rooms, all near the lively Cours Julien (33-4-84-35-20-00; doubles from $88).
Meeting point and melting pot, the Vieux-Port is where Marseille was born 2,600 years ago.
Today, chandlers and shipyards share space with trendy bars and fringe theaters, and the port recently unveiled its new face—by Norman Foster and Michel Desvigne—with broad esplanades for promenading and café terraces. The must-see highlights: 1 Quai des Belges Boats unload still-flopping fish into blue trays at this morning market. It's also where you board excursion boats to the calanques. 2 La Canebière The grand boulevard leading from the port through town, it's Marseille's answer to the Champs-Élysées—albeit shabbier. 3 La Samaritaine Opened in 1910, this café is a chic rendezvous spot for breakfast or tea, with excellent people watching (2 quai du Port; 33-4-91-90-31-41; entrées from $11). 4 Une Table au Sud The restaurant's inventive specialties include a bouillabaisse milk shake—a savory blend of mascarpone, whipped potatoes, and Parmesan with John Dory slices on the side (2 quai du Port; 33-4-91-90-63-53; prix fixes from $40). 5 La Caravelle Squeeze onto the tiny balcony at this cocktail bar in the Hotel Belle-Vue for the best mojitos in town. There's live jazz on Wednesdays and Fridays (34 quai du Port). 6 Hotel Dieu See "H is for Hotels". 7 Le Panier The city's oldest district is a tangle of multicolored tenements, ancient shopfronts, and small squares filled with artists and young Marseillais. 8 La Maison Diamantée This sixteenth-century mansion has an instantly recognizable diamond-patterned facade (rue de la Prison). 9 La Maison du Pastis France's essential anise-flavored tipples, pastis and absinthe, come in 75 varieties at this shop, which also stocks ouzo and raki. And they'll let you try a couple before you buy (108 quai du Port). 10 Le Bar de la Marine This 1930s sailors' haunt draws a cheerful, eclectic crowd to its old zinc bar and cozy mezzanine (15 quai Rive Neuve). 11 Le Trolleybus Marseille's oldest nightclub is a maze of discrete spaces and styles—there's a whiskey bar, dance floors, even a pétanque ground—in an old shipbuilding arsenal (24 quai Rive Neuve). 12 ThÉÂtre National de Marseille– La CriÉe Once a fish market, it's one of France's edgiest theaters (30 quai Rive Neuve; 33-4-91-54-70-54). 13 Rowing Club de Marseille Upstairs, insiders eat tapas, grilled fish, and luscious gâteaux with a view of the marina—it's open to non-members, too (34 blvd. Charles Livon; 33-4-91-90-07-78; entrées from $26).
CLASSIC Navettes—the long, orange-blossom-flavored biscuits from Four des Navettes—are said to resemble the boat that brought Mary Magdalene ashore at nearby Stes-Maries-de-la-Mer. They're still made in the oven that was in use when the bakery opened in 1781 (136 rue Sainte; tin of 12, $22).
CURRENT A stylish coat or a pair of floral-print trousers from rising young Marseille fashion label Sessùn. Designed in Marseille by Emma François—who has done lines for Madewell—the pieces feature vintage touches like ribbon collars (6 rue Sainte).
Photographs, from top: iStockPhoto; Buildings by Brown Bird Design; J. Garcia/Corbis; Bertrand Gardel/Corbis; Illustrations by Peter Oumanski; Still life by Josephine Schiele


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(CMT Offstage keeps a 24/7 watch on everything that's happening with country music artists behind the scenes and out of the spotlight.)
As much as I would love to think Hunter Hayes is in love, he is not. At least not with Selena Gomez. So there will be no Gomayes. No Selener. And no Hamez. No one really knows how the dating rumors got started, but both Hayes and Gomez have been denying them from the start. And Hayes even told CMT Radio all he has ever done is said hello and shaken hands with Gomez. "It is strange. That's the one part that nobody kinda can tell you about or prepare you for," Hayes said of being thrust into the rumor mill. "I kinda felt bad for Selena because we did meet, and she was awesome, but we literally just shook hands and said hello." He does have a celebrity crush, though, so maybe someone famous will eventually be somebody's heartbreak. But he's too much of a gentleman to name names, and he doesn't want it to get weird if and when they do meet. "My celebrity crush is not gonna find out who my celebrity crush is anytime soon," Hayes said. "I may keep that to myself because if I do meet her and she already knows about it, that could be awkward."


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Setting up my mobile phone for internet
Setting up my mobile phone for MMS
Installing and using apps from Google Play
Writing and sending MMS
Transferring files between a computer and my mobile phone
Want to set up your mobile phone for internet? Follow these easy instructions.
Find "Access point names"
Slide your finger down the display starting from the top edge of your mobile phone.
Tap the settings icon.
Tap Networks.
Tap Tethering & networks.
Tap Mobile networks.
Tap Access point names.
Create new data connection
Tap the menu icon.
Tap New APN.
Enter data connection name
Tap Name.
Key in SingTel Internet and tap OK.
Enter APN
Tap APN.
If you're on a pay monthly rate plan:
Key in e-ideas
If you're on a pay as you go rate plan:
Key in hicard
Tap OK.
Enter username
Tap Username.
Key in 65ideas and tap OK.
Enter password
Tap Password.
Enter country code
Tap MCC.
Key in 525 and tap OK.
Enter network code
Tap MNC.
Key in 01 and tap OK.
Select authentication type
Tap Authentication type.
Tap PAP.
Select APN type
Tap APN type.
Key in default and tap OK.
Save and activate data connection
Tap Save.
Tap the field next to the data connection to fill in the field.
Return to the home screen
Tap the home icon to return to the home screen.
Tap anywhere to dismiss
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From Friday, July 20, 2018
To Tuesday, July 31, 2018
To Tuesday, July 31, 2018
Twelve-day Alaskan mission trip (leave Friday afternoon and return early Tuesday morning); working on construction of simple, dry cabins for graduates of the local rescue mission. Involving finish work on three cabins and roughing in construction on another three.
Location - Various locations throughout Alaska


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Our customer care team may be able to locate this product for you. Please complete the details below, and we'll endeavour to reply within 3 working days.Close
Sizes length width one 180 cm
70.87 inch
23 cm
9.06 inch
Accessories are one size. The proportions vary from style to style.
Please note that stretch and ease are natural properties of our knitwear and the closeness of fit will vary according to type of style.
A Length B Width


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A woman is face as her business card, on which one can learn a lot about her character and habits, her way of life and her attitude towards herself. What if I do not want to go to a plastic surgeon? You can become significantly younger with the help of botox for migraines covered by insurance.
What is botox for migraines covered by insurance and how do injections work?
The amazing properties of botulinum toxin (botox for migraines covered by insurance) and its effect on the skin was discovered quite accidentally in 1982, when clinical studies were conducted in the treatment of strabismus and blepharospasm.
The drug itself is a weakened botox for migraines covered by insurance, which is produced by the life of the bacterium Clostridium botulinum. When ingested, toxins can block the work of the muscles, causing their paralysis.
Control injection under the skin of small doses of botulinum toxin causes local paralysis of facial wrinkles. The effect lasts up to 6 months.
For or against botox for migraines covered by insurance?
Do or not do botox for migraines covered by insurance? Some say that the drug quickly eliminates wrinkles and signs of aging, while others discuss the harmful properties of botox.
When Botox is administered, facial wrinkles relax under the skin. This property of the neurotoxin is used in the forehead, the zone between the eyebrows, the periorbital and perioral regions.
In addition, it was observed that botox for migraines covered by insurance into the axillary basins, palms and feet reduce the separation of sweat, which has become widely used in the treatment of hyperhidrosis. And some patients after the injections completely get rid of migraine and migraine-like pain. Neurotoxin is completely eliminated after 6-9 months.
Does botox for migraines covered by insurance have cons?
The Ministry of Health of many countries, exploring botox, tried to detect its negative effect on human health, but they did not find it. botox for migraines covered by insurance should be done no more often than once every 6 months.
As for the toxicity of the drug, you can also be calm – there is no danger of poisoning or intoxication with botox for migraines covered by insurance, since for this purpose it is necessary to enter doses in the body that are thousands of times greater than cosmetic doses.


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William Butler Yeats
William Butler Yeats [W.B. Yeats] (13 June 1865 – 28 January 1939 / County Dublin / Ireland)
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Introductory Lines (The Shadowy Waters)
I walked among the seven woods of Coole:
Shan-walla, where a willow-hordered pond
Gathers the wild duck from the winter dawn;
Shady Kyle-dortha; sunnier Kyle-na-no,
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This drawing is fabulous in a hundred ways. My inner sicko is laughing very hard.
More! I want more!
hurry up with the next installment willya?
I think I totally missed the point.
We can arrange a full scale analysis of that.
Design and style that is definitely the result of pure logic' my foot you will not should seem earlier the mascot to see logic has nought to complete with it, Voisins are out there like Bristol Cars and Siddley Armstrongs also designed by aeroplane manufacturers for people who choose to "believe" that there is certainly some pure logic inside their undoubtedly distinctive vehicles.
Hello! That is Pat's daughter….seen Pat's Purple Haze was completely ready?!?