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Sabre Sailing Dinghy
Australia's most popular one design single handed class. The fun Single hander that is easy to sail but difficult to master.
Prize: ISP Sabre Hull valued at $8,000
Prize Winner is Matthew Depiazzi, Gosnells WA
We have arranged some great quality regatta merchandise through 4Branding.
All entries received prior to 23rd November will receive
Short Sleeve or Long Sleeve Polo, Sport Cap, Beach Towel, Drink Bottle, Shoe/Gear Bag
$125.00 value in merchandise included in your entry fee.
View Size Charts (Short Sleeve) (Long Sleeve)
Accommodation Booking Information
Click here to view accomodation booking information flyer.
Why come to the Nationals at Perth Dinghy Sailing Club
- Great race management by experienced team
- Family Atmosphere club
- Perfect location - Very close to the city, on the way to the beaches & Fremantle, up the road from Kings Park Botanic Garden
- Plenty of reasonable priced accomodation located across the road.
- Safe sailing area - racing will be held in Matilda Bay on the Swan River
- Grassed rigging areas and close container storage area.
- Easy beach launching access
- Plenty of free parking
- Spectators can watch the racing - close to shore/bay racing
- Get a group together and organise to transport your Sabres in a container.
- Great social events planned
- Put your bike in the container with your boat and go for rides around the extensive cycleways around the river, or ride into the city.
- Book your flights now, the earlier you book the better the price.
- Make a holiday of it and stay a few extra days prior to or after the regatta and visit the South West of WA or many of Perth's other attractions.
You may have heard there is construction going on at the Perth Dinghy Sailing Club.
Yes there is currently construction going on in the University of WA Car Park, behind the yacht club. This is Forrest Hall and when finished will be additional university accomodation. Please note however PDSC is still operating as normal and plenty of parking is available on club grounds. There is also still plenty of space for shipping container storage. Contruction will not affect this event and parking will not be a problem.
Tourist Information
Visit Perth City for information on City of Perth's attractions and things to do
Western Australia Tourism
Experience Perth
Should you require assistance or additional information, please contact us via firstname.lastname@example.com
or contsct Brian Jones M: 0438 516 324
Alll media or sponsorship enquiries to Chelsea Baker email@example.com M: 0423 164 886
To view more photos from 2013/14 Perth Nationals click here


text: News & Updates One Year Anniversary of FracFocus 4/12/2016 FracFocus Celebrates Its 5th Anniversary Oklahoma City, OK - Five years ago, the Ground Water Protection Council and Interstate Oil and Gas Compact Commission partnered with a vision to provide the public a one-stop site to access information on chemicals used in hydraulic fracturing operations by location. The partners launched FracFocus.org, the national hydraulic fracturing chemical disclosure registry on April 11, 2011. Read more about 4/12/2016 FracFocus Celebrates Its 5th Anniversary 2/26/2015 Major Improvements to FracFocus Announced As it enters its fourth year, FracFocus, the nationwide system for disclosing chemicals used in the hydraulic fracturing process, continues to improve its performance and versatility.The Ground Water Protection Council (GWPC) and Interstate Oil and Gas Compact Commission (IOGCC), joint venture partners in the FracFocus initiative, announce the coming release of improvements to FracFocus' system functionality. The new features for 2015 include: Read more about 2/26/2015 Major Improvements to FracFocus Announced 10/22/2014 FracFocus Help Desk now available FracFocus has instituted a Help Desk to address any issues you may have in using the system. You can reach the Help Desk Monday-Thursday from 8 AM to 5 PM and on Friday from 8 AM to 4 PM CDT at 405-607-6808. Read more about 10/22/2014 FracFocus Help Desk now available 1/7/2014 University of Oklahoma offers free course to public The University of Oklahoma is offering an on-line course on "Hydraulic Fracturing and Water Resources", free of charge to the public. The course begins January 13th. You can register for the course at https://janux.ou.edu/landing . This is a good opportunity to learn more about the process of hydraulic fracturing and the water resources related to the process. Read more about 1/7/2014 University of Oklahoma offers free course to public 6/13/2013 Operator Training Webinar Now Available A training webinar for users of the FracFocus disclosure submission system is now available. The hour-long webinar shows operators, service companies, registered agents and state agencies how to register their organization and set up their Representatives, Supervisors and Data Submitters. With the added steps involved in FracFocus 2.0, the training discusses XML, how operators can complete and submit disclosure forms and how to manage the records and users in the system. Read more about 6/13/2013 Operator Training Webinar Now Available 5/29/13 FracFocus 2.0 to revolutionize hydraulic fracturing chemical reporting nationwide OKLAHOMA CITY –FracFocus.org, the national hydraulic fracturing chemical disclosure registry, will implement major upgrades beginning June 1, 2013, that will dramatically improve the site's functionality for state regulatory agencies, industry and public users.The enhancements to FracFocus and its system has been referred to as FracFocus 2.0. It contains several new features that will enhance the usability and informational content of the system. Read more about 5/29/13 FracFocus 2.0 to revolutionize hydraulic fracturing chemical reporting nationwide 5/28/2013 Map Search Issues Being Addressed Recently, we were informed that users were experiencing a problem accessing FracFocus records using the Map Search feature of the website. We have investigated this problem and found that the principal causes are:1. A glitch in the Google maps system that results in the serving of a previous version of the map being displayed when a new search is initiated. This is usually caused by the user submitting a new request while a current request is being processed. Read more about 5/28/2013 Map Search Issues Being Addressed 4/24/2013 FracFocus Responds to Harvard Study On April 23, 2013 we were made aware of a study released by Harvard University in which they assert that FracFocus is not a good tool for regulatory purposes. Read more about 4/24/2013 FracFocus Responds to Harvard Study 4/17/2013 New Publication Added to FracFocus A new publication has been added to the FracFocus publications list. Titled Hydraulic Fracturing 101, this Society of Petroleum Engineers paper was written by George E. King, a Professional Petroleum Engineer whose expertise in the field of oil and gas exploration and production is well known throughout the petroleum industry. This paper is an excellent primer for anyone who would like to learn more about the practice of hydraulic fracturing. You can read the paper by clicking HERE. Read more about 4/17/2013 New Publication Added to FracFocus 1/30/2013 IMPORTANT FRACFOCUS ANNOUNCEMENT! Read more about 1/30/2013 IMPORTANT FRACFOCUS ANNOUNCEMENT! Pages1 2 3 next › last »

subset: commoncrawl


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Tydskrif vir Letterkunde
versión On-line ISSN 2309-9070
versión impresa ISSN 0041-476X
HENDRICKS, Frank. Illuminating the neglected: a view on Adam Small's literary integration of Kaaps. Tydskr. letterkd. [online]. 2012, vol.49, n.1, pp.95-114. ISSN 2309-9070.
This article examines the literary reflection of Kaaps in the oeuvre of Adam Small from the perspective of an egalitarian approach to linguistic diversity. According to this approach the standard and non-standardised varieties of a particular language, such as Afrikaans, should be regarded as linguistically equipollent and equally valid codes of communication. Alongside reflections on the dialectological and sociolinguistic nature of Kaaps as well as the contextualisation of Small's choice of Kaaps as literary medium, it is shown how Small's personal views on this variety of Afrikaans, the ways in which it is textually integrated and the portrayal of it's linguistic nature implicitly serve as demarginalising and destigmatising mechanisms. It is emphasised how Small's groundwork regarding the illumination of the intrinsic linguistic nature and functional sufficiency of Kaaps, have paved the way for Kaaps to be recognised as a potential feeder source in the re-standardisation of Afrikaans which appears to be imminent. This is viewed as one of Small's great historical contributions
Palabras clave : Adam Small; demarginalisation; code; variety.


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Rarely does a singer come along in whom virtuosity meets sensitivity. Jo Lawry at once tests the limits of technical facility and explores the furthest reaches of musical expression. Her music, steeped in the jazz tradition without being constrained by its traditional forms and functions, demonstrates a unique combination of maturity and inventiveness.
Jo Lawry's debut album I Want to Be Happy was released in 2008 to rave reviews and named among the "Best CDs of the Decade" in Downbeat Magazine. In addition to working with her own quintet, Jo is the vocalist for the Fred Hersch Pocket Orchestra, a quartet whose album, Live at Jazz Standard was recently released on Sunnyside Records. Jo is also a member of the Irish/Brazilian/Jazz quartet, James Shipp's Nós Novo, providing lead vocals, fiddle, mandolin and melodica. This group recently released their debut CD Strange Sweethearts in America, which the New York Times called "a striking new album… which advances a jazz-based take on traditional Celtic music." Jo has been featured as a guest on numerous recordings; stand-outs include Dr. Lonnie Smith's album Rise Up! and Kate McGarry's Grammy-nominated If Less is More… Nothing is Everything.
Jo is also quickly becoming known to audiences beyond the jazz genre, through her work with Sting. She first joined Sting in 2009 as a backing vocalist for the filming of his live concert DVD A Winter's Night… Live From Durham Cathedral. Following this project, she appeared with him for several other concerts and TV appearances on vocals and violin. In 2010, Jo was invited to join him as sole backing vocalist on his international orchestral tour.
Jo grew up on an almond farm in South Australia and, after a brief affair with operatic study, began her instruction in the Jazz Department at Adelaide University's Elder Conservatorium. Jo has received many honors including the prestigious Fulbright Scholarship for study in the United States to complete her Masters degree in Jazz Performance (2003). She was a semifinalist in the 2004 Thelonious Monk International Jazz Competition, and she won second place in Australia's National Jazz Awards in 2005. In 2006 Jo commenced her studies at New England Conservatory for a Doctor of Musical Arts in Jazz Performance. Upon graduation, she will be the first vocalist to be awarded this degree from NEC.
In 2008 she was selected by Carnegie Hall to participate in a week-long collaboration with emerging vocalists from all over the world, led by Bobby McFerrin. Her relationship with Carnegie Hall continues as she is now a featured artist in their Musical Connections pilot program. Jo is also Artist-in-Residence at the United States Embassy of Australia.
Jo currently lives in New York, where she leads her own jazz quintet. She appears regularly at NYC clubs from Birdland to Joe's Pub, and her shows are a recurring "Critic's Pick" for Time Out New York, which recently stated ""Australian vocalist Jo Lawry numbers among our favorite discoveries of the past year."


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In some parts of El Salvador, crime is a big problem. Gangs try to convince youth that crime can provide a better life with little effort.
We recently talked with Yesenia Alfaro, CFCA project coordinator in Santa Ana, who said the moral support of sponsorship is helping youth resist the lure of crime and gangs.
What are the challenges that youth in El Salvador face?
They live with discouragement, with an education system that is not the best.
If they can succeed in school or in high school, the percentage of college graduates is very low. Even if they finish college, the employment opportunities are minimal.
Keeping young people motivated requires hard work and effort, because they have all these situations. In a numerous family, the oldest sibling often has to sacrifice their education.
Single mothers have to raise their children as a mother and as a father. This is also one of the difficulties that young people have, in that there is no father figure in many homes.
I believe the hardest part is that young people are constantly invited to be part of a gang and are vulnerable because they have so many needs and few options.
The gang members say to young people, "You can't earn in the decent way, but there is an easy way to earn money. You'll have everything easily and faster."
Sometimes the youth believe them and join the gang. But sometimes they don't want to get involved, and then gangs try to hurt them or their family members.
Do you know a story of a youth involved with gangs?
In the program we have communities that are at high risk of gang violence. These places are protected by gangs, in which at least one family member is related to gangs.
In San Salvador, the capital, we had a youth in the CFCA sponsorship program who was involved in gang-related incidents along with his mother. They were arrested by the police. They left the program shortly afterward.
Currently it is not easy to distinguish who is in a gang and who is not. In high-risk communities, the youth are very vulnerable to joining a gang.
How does CFCA help youth overcome these obstacles?
We support them not only economically, but also emotionally. Being part of an organization is an additional motivation, as well as sharing a friendship with a sponsor and the CFCA community.
Our help with educational and nutritional costs is also a motivation, and the family is motivated to make an effort to cover their other needs.
Youth in the sponsorship program reach higher levels in education in their communities compared with youth who aren't in the program.
We encourage parents to talk with their children so they can know who their friends are and where they're going.
For parents who attend the CFCA meetings, we always emphasize good communication with their children. We encourage them to be aware of every detail.
Usually whenever these gang members or criminals share their stories, they speak of a family breakdown ñ that their family never paid attention to them. They didn't find the love at home that they found in gangs.
We talk with mothers about this all the time. We have workshops on how to educate children.
Mothers who have children need to start now, because when they get older it is very difficult to talk with them.
We believe that the family is very important to help youth stay away from these environments.
What helps us is that we don't work alone with the child or young person; we need the support of their family.
What is CFCA's role in these situations?
Basically our role is being able to learn as much as possible from the youth, to be able to give options and not close the doors. We are trying to open doors for young people.
If we see that the youth really want to follow our rules, policies and guidelines and even if their conditions are not the best, we try to help them.
If they are knocking on doors and all are closed, they will choose the easier way: crime.
What are your challenges?
The biggest challenge, I think, is the discouragement in families. Getting people motivated and having families believe in themselves are the difficulties we go through.
What are some causes for the high percentage of absenteeism in schools?
Sometimes children and youth have to work. Many families work in agriculture. In some cases the older brother has to work to help their younger siblings.
Recently we visited one community where a mother commented that her 20-year-old son had to work different jobs since he was 14. He did this so his younger brother and sister could attend school. She is a single mother.
Many Salvadoran families ask one son to sacrifice for the other siblings, so they would be able to study.
Do you hear about gangs inside schools?
I've heard stories from CFCA social workers in communities. They say gangs are not only in public schools but also in private schools and college.
In different institutions, there are gang members looking for more people to enter into gangs and sell drugs or extort money from people.
The government is supposed to send the police into schools, so they can spot these gang members. But it's very difficult to detect who is a gang member.
Some girls have stopped attending school, because gang members wanted them to be their girlfriends. They had to leave school because they aren't safe on their way home.
Can you tell a story of a youth with gangs?
About five or six years ago we had an incident. It was the main reason we stopped bringing youth into other communities.
A CFCA social worker was visiting a community with a young CFCA scholar. They got off the bus when a gang member grabbed the CFCA scholar and took him away.
When gang members take someone, the end is almost always fatal.
The social worker was very scared and ran to the CFCA office in that community. The office members called us and we tried to see what we could do.
It was a terrible time for us. We thought he would turn up dead, but thanks be to God, he appeared 5 hours later, all beaten, but alive.
The social worker took him to hospital, where X-rays showed he had internal injuries.
The gang members did this because the CFCA scholar had entered into a different community. When the gang members didn't recognize him, it was like they gave him a lesson: "Don't come back to this community."
The social workers always have to go with their CFCA shirts as identification.
If CFCA staffers don't know the community or don't go with another CFCA staff member who is from the community, they are in danger. That is one of our most difficult challenges.
All our activities are organized so that a young person does not have to take risks going to another community, even when interacting with youth from other communities.
We have to take all these details into account for CFCA birthday celebrations and workshops. Any activity that is in a group must be within their community.


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Skin is in. Now the question is how do we keep that skin clear and smooth? Lavera has revamped their facial cleansing line and it's better than ever! With all-natural regimens including a facial cleanser, a toner, and a moisturizer your skin is sure to thank you with flawless radiance. Products in the skincare world typically include salicylic acid, benzoyl peroxide, or glycolic acid. These agents are rough on your skin, especially for everyday use. Other additives such as, of Parabens, Phthalates, petroleum, and synthetic fragrances or dyes are common among face cleaners. They are unnecessary and have been linked to health issues such as cancer.
Lavera utilizes the finest of natural ingredients. Introducing a gentle ginkgo and organic grape derived complete skin cleansing regimen. This system gives people an effective and natural option to skin care. Lavera's Invigorating Cleansing Gel, Purifying Scrub, Purifying Toner, and Calenula Mattifying Balance Cream are created for people with normal to combination skin types.
Lavera's regimen utilizes ginkgo extracts to refresh and purify and organic grapes to even skins complexion. Ginkgo's main promise in skin care is its antioxidant compounds. Since much of skin aging is caused by free radical damage, ginkgo's ability to protect against free radicals may help protect skin from signs of aging like wrinkles, sagging, and age spots. Extracts from ginkgo leaves have also shown anti-inflammatory and antibacterial properties, which reduce the occurrence of acne, as well as other skin concerns, and keep skin free of bacteria and other debris. Organic grapes also offer many effective benefits. Grapes are filled with alpha-hydroxy acids. This ingredient is found in many skin firming and anti-wrinkle creams. No matter what age or skin type, this fruit is filled with nutrients sure to keep your face clear and fresh.
To complete your skin care regimen, after cleansing and toning, apply Lavera's Calendula Mattifying Balancing Cream. Calendula is known for fast healing and regeneration of the skin because of its anti-inflammatory and antibacterial properties. This will keep the moisture in and eliminate the oily shine we all despise.
We've put together a fabulous facial regimen for Normal and Combination Skin as a value priced kit, with the bonus of a free organic make up bag. We want to give you a chance to try it for yourself and see the difference. The Kit contains Lavera's Purifying Scrub, Invigorating Cleansing Gel, Purifying Toner, Mattifying Balance Cream, and a free organic make up bag, giving you the ultimate package in natural cleansing and moisturizing. Let nature do its work and give Lavera's skin regimen a try!


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The challenges of caring for a loved one who's suffering from dementia can be overwhelming. Our professional caregivers in Lisbon, Wisconsin can ease the burden with customized home health care services that ensure a higher quality of life for you, your loved one, and your entire family.
To provide the most effective method of home care services for your family's unique situation, Home Helpers of Greater Milwaukee's dementia caregivers receive specialized training and are highly experienced in dementia care; in fact, many are certified in Alzheimer's care through our partnership with the National Certification Board for Alzheimer Care (NCBAC).
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Other Care Services for Lisbon, Wisconsin:
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text: News Colleges See Positive Aspects To A Bad Economy By Emily McCord • Sep 10, 2009 It's the first week of school at Wright State University, and Cathy Davis has good reason to believe this year is going to be a busy one. "We've seen an increase in transfer applications each year, but this year there's been a significant increase in applications we've received," says Davis, the Director of Admissions at Wright State. Facing the Mortgage Crisis: The Next Steps Community Forum By WYSO News • Aug 28, 2009 From our public forum on Aug. 20, 2009 discussing foreclosure, mortgage problems and struggling neighborhoods. Live on Excursions: Peter Mulvey By Kent Montgomery & Niki Dakota • Aug 17, 2009 Susan Frikken Who makes a perfect "road trip record?" According to Niki Dakota, it's Peter Mulvey. Singer-songwriter Peter Mulvey has been recording and touring as a solo artist since the early 1990's. Originally from Wisconsin, Mulvey's music has taken him everywhere from Dublin, Ireland to the streets of Boston, where he performed early on in his career. Over the last 15 years, he has steadily developed a following through critically acclaimed folk records like 2006's "The Knuckleball Suite." Live on Excursions: Dan Hicks By Kent Montgomery & Niki Dakota • Aug 11, 2009 Jokes abound in this laughter-filled 2009 Excursions interview with multi-talented country and jazz musician Dan Hicks. Hicks has been playing music for over 50 years. Beginning as a drummer as a young child, Hicks joined folk-rock group the Charlatans in 1965. Hicks struck out on his own in the late '60s, putting together backing band the Hot Licks for a string of records, including 1973's classic "Last Train to Hicksville." The band broke up in the mid-70's, but has since reformed, releasing several records and touring internationally for the last decade. "Forbes 10 Fastest Dying Cities" Symposium In Dayton This Weekend By Emily McCord • Aug 6, 2009 This weekend, communities are coming together in Dayton to show there's still some life in economically depressed areas. For the past year, Dayton, Cleveland, Youngstown and Canton have been laboring under the title fastest dying cities in the country. It was last August that Forbes called them as the walking dead. Foreclosure Scams By Emily McCord • Jul 25, 2009 As home foreclosures rise, so do the number of people trying to take advantage of those in a bad situation. More and more, scams are popping up across Ohio. In May, the Attorney General's office launched a crackdown on the shady practices. WYSO's Emily McCord reports on the on-going effort. The Mortgage Crisis and Appraisers By Aileen LeBlanc • Jul 24, 2009 When a house is for sale, an evaluation is done to determine its value before a loan is made. Appraisers are trained to make judgments about the value of properties with "boot-on-the-ground" inspections. In the past, a few appraisers were influenced by over zealous brokers and lenders. Now there are new guidelines in place. But are they protecting the consumer or making money for the lender? Facing Foreclosure on Grange Hall Road By Aileen LeBlanc • Jul 23, 2009 For people in the Miami valley who are in trouble with their mortgage payments, a phone call to the lender is often the first step to some sort of a solution. Many major banks have agreed to work with the Home Affordable Modification Program which was designed to help homeowners stay in their homes. But sometimes when phone calls go unanswered and communication is delayed, foreclosure will proceed. A House No Longer a Home By Jerry Kenney • Jul 22, 2009 People facing foreclosure are obviously dealing with a very difficult situation. Though people are finding assistance through the 211 help line and other services, some people feel they have no choice but to leave their homes and sometimes, their possessions behind - before the foreclosure process is even complete. What's left is a neighborhood dealing with an empty house and a new set of new problems which affect everyone on the street. WYSO's Jerry Kenney discovered such a neighborhood near his home in Miami Township. Here's what he found... Financial Fitness By Juliet Fromholt • Jul 21, 2009 Community organizations around the Miami Valley are offering foreclosure counseling and financial literacy classes. In Clark County, the foreclosure rate continues to rise and experts say it is likely to for the foreseeable future, WYSO's Juliet Fromholt has the story of what one Springfield organization is doing to educate people about their mortgages, their homes and their Financial fitness. Pages« first ‹ previous … 1145 1146 1147 1148 next › last »


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Who's Favored?
Series tied, 1-1; scene shifts to Busch Stadium for Game 3 this evening. Which team has the edge?
Well, there are numbers that favor the Phillies and numbers that favor the Cardinals. Some numbers are of substance, some are just numbers and perhaps none apply because we are in a new five-game season.
Anyway, here we go:
Cardinals are dead even at home and on the road, 45-36.
Phillies have the best road record in the majors, 50-31, a club record for wins.
Cardinals are 3-2 at home vs. the Phillies, who are 15-11 in the history of Busch Stadium.
Cardinals are at their best on Tuesdays, 16-10; Phillies are 13-13.
Cardinals are at their worst on Wednesdays, 10-15; Phillies, their best, 21-5.
Hamels was 0-1, 5.14 ERA vs. St. Louis this year (one September start); 2-3, 3.26 in his career. His last win was September 8 (0-2, one no decision, one relief appearance since).
Garcia was 0-0, 0.00 with one earned run in 15 innings vs. the Phillies this year; 2-1, 1.20 in his career. He was 3-0, 2.64 in September.
Hamels is tied with Steve Carlton for the most career postseason wins for the Phillies, 6. ERA is 3.33. Game 3 start ties Lefty for most by a Phillie, 13.
Garcia is making his first postseason start.
Phillies have scored just three runs in Hamels last three starts (0-2).
Garcia ranks first in the NL in highest support average, 5.92 runs per game.
Convinced or confused? Best idea is to print this brilliant piece and put the paper in the bottom of your bird cage or the kitty litter box.
Phillies Postseason History
October 4 (2-4 record)
1950 WS #1 at Shibe Park: Because Robin Roberts started four times in the last eight games, manager Eddie Sawyer surprises everyone by naming relief ace Jim Konstanty the starter. Konstanty allows one run over eight innings but Vic Raschi blanks the Phillies on two singles for a 1-0 Yankees win.
1977 NLCS #1 at Los Angeles: Greg Luzinski's booming two-run homer gives the Phillies a first-inning lead over the Dodgers but Ron Cey's grand slam off Steve Carlton ties it in the seventh. Singles by Bake McBride, Larry Bowa and Mike Schmidt produce two ninth-inning runs and a 7-5 win.
1978 NLCS #1 at Veterans Stadium: Steve Garvey's three-run homer triggers a four-run third inning. Dodgers win, 9-5, as reliever Bob Welch allows only one run over 4.1 innings.
1983 NLCS #1 at Los Angeles: Mike Schmidt homers as the third batter of the game and Steve Carlton (7.2 IP) and Al Holland (1.1) combine to blank the Dodgers on seven singles, 1-0.
2007 NLDS #2 at Citizens Bank Park: Jimmy Rollins hits a lead-off homer and a second-inning triple giving the Phillies a 3-2 lead over the Rockies. Colorado rebounds with 4-run innings in the fourth (Kazuo Matsui's grand slam) and sixth en route to a 10-5 win. Rockies lead Series, 2-0.
2008 NLDS #3 at Milwaukee: Playing their first postseason home game since 1982, the Brewers beat the Phillies, 4-1, behind David Bush. Phillies lead the Series, 2-1.
Alumni Postseason Memories
What is your favorite memory of postseason baseball as a child? . . . What is the biggest change from the regular season? . . . What is your fondest personal postseason memory?
Clay Dalrymple (C, 1960-68)
"I was a Red Sox fan growing up and Ted Williams was my idol. Back then you either listened to the games on radio or watched on TV.
"The postseason (1969, Orioles) is much different. It seems like everything is going a million miles an hour. Before your first at-bat, you need to have a little conversation with yourself because your heart is breathing so fast. Need to settle down.
"I only had two at-bats in the World Series but I have two hits, a single off Nolan Ryan and another one off Tom Seaver two Hall of Famers. Can't get any better than that."


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If I were a semiautomatic pistol, I would be getting a complex. What Democrats really hate is semiautomatic rifles, although it isn't clear exactly why. True, the Sandy Hook killings were carried out with such a weapon, but in the scheme of things, rifles of any sort are rarely used as murder weapons. In 2011, according to the FBI, there were 14,612 victims of homicide in the U.S., down 14.7% from 2007. Of those 14,612, only 323 were murdered with any type of rifle. More than five times as many were killed with knives. More were killed with blunt objects, and more than twice as many were killed with the assailant's bare hands. So it is hard to understand the current obsession with semiautomatic rifles.
Nevertheless, the obsession is there. And when liberals set out to ban semiautomatic rifles, if you read the fine print, they always sweep in a greater or lesser number of semiautomatic pistols, too. What puzzles me is why they always seem to leave out revolvers. Revolvers are used in vastly more crimes than semiautomatic rifles, so why do they get a free pass?
True, the cylinder of a revolver generally holds fewer bullets than the magazine of a semiautomatic rifle or pistol–usually five, six or seven, although some cylinders hold nine .22 caliber bullets. But so what? A lunatic bent on mass murder can just bring along three or four revolvers. Or he can reload.
For a long time, a gangster with a revolver was a symbol of menace:
Of course, the good guys used them too:
Revolvers are as lethal as any other firearm and there are still millions of them being sold, so it is not clear why they are being left out of the current gun control debate. I suspect the main reason is that the people who are arguing for gun control have no idea what they are talking about, don't know the differences between one type of firearm and another, and find the word "semiautomatic" scary and therefore politically useful.
Of course, your attitude toward firearms can depend on whether you need one or not. Dianne Feinstein, who is introducing draconian gun control legislation in the Senate, formerly had a concealed carry permit. In 1995, she explained:
[T]he [New World Liberation Front] shot out all the windows of my home and I know the sense of helplessness that people feel. I know the urge to arm yourself, because that's what I did. I was trained in firearms.
When I walked to the hospital when my husband was sick, I carried a concealed weapon. I made the determination that if somebody was going to try to take me out I was going to take them with me.
So, what happened? Feinstein explains that she "got rid of the permit once the New World Liberation Front was no longer a threat to her." So obviously, once Feinstein no longer needed to carry a firearm, no one else needed to, either. It's typical liberal hypocrisy. Barack Obama and David Gregory think Wayne LaPierre's proposal to post armed guards in schools is outrageous. They send their children to Sidwell Friends, which, according to news reports, has eleven armed guards on duty, and that is before you get to the Secret Service detail for Malia and Sasha. It's typical liberal logic: my kids are safe, who cares about yours?
So I guess we should be grateful that they apparently intend to let us keep our revolvers.
Images courtesy of Shutterstock.


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SKU:4276Artist:Compatible Figures:Aiko 3Compatible Software:Poser, DAZ StudioInstall Types:
SKU:4276Artist:Compatible Figures:Aiko 3Compatible Software:Poser, DAZ StudioInstall Types:
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'The hunt is up, the morn is bright and grey, The fields are fragrant and the woods are green. Uncouple here and let us make a bay...' William Shakespeare
Tail Gunner sees Aiko 3 through almost any adventure you can conjure in your mind's eye. Whether she's stalking killer aliens in a funky sci-fi setting, or laying in wait for her 'mark' on a desolate street corner, this girl is ready for action.
The Tail Gunner clothing pack for A3 comes complete with halter top, jacket, shorts (with attached garters), high boots and her weapon of choice, Gladius. These amazingly detailed models are complemented with 2 complete sets of texture.
Add-ons for this product.
What's Included and FeaturesFeatures
- Uses the same textures as Tail Gunner V3
- 4 conforming figures
- Halter top (CR2 & OBJ)
- Jacket (CR2 & OBJ)
- Flare Morphs to help simulate movement
- Shorts (with garters) (CR2 & OBJ)
- Tall boots (CR2 & OBJ)
- Platform morphs
- The following morphs are supported where pertinent
- Realistic
- Stylized
- Young
- Voluptuous
- BreastSize1
- BreastSize2
- BreastSize3
- BreastSize4
- BrstCleavage
- WaistNarrow
- TummyOut
- GluteBig
- HipSmall
- JCMlCollarBend
- JCMrCollarBend
- Gladius Gun prop (PP2 & OBJ)
- 2 complete sets of textures:
- Metallic: Sci-fi metallics and verigated leathers
- Destroyed: Destroyed denim, black leather and funky velvet patches
- Partial Poses
- Left and Right hand grips for the gun
- Partial poses for aiming the gun left and right
NotesThis product has 2 installers.


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My two most often-used commands are top and ps -ejH. I decided to make a couple of panel launchers for them, with homemade .png icons which read (wait for it) 'top' and 'ps'.
'top' works fine. Click on the icon, and xfce4-terminal opens with top running.
'ps' doesn't. Click on the icon and a terminal window appears and vanishes. I've tried a whole range of possibilities, including specifying various commands for the launcher beginning with 'xfce4-terminal'.
What works is this command: xterm -hold -e ps -ejH. Good old xterm opens, executes ps -ejH and stays open.
There doesn't seem to be a '-hold' option for xfce4-terminal. Any other way I can keep it open with a single command?
Check the man page for exo-open. It might be what you're looking for.
Hi, etniWings.
Maybe I wasn't clear enough about the problem!
I can launch xfce4-terminal with a panel launcher with any one of a whole range of command options. The problem is that xfce4-terminal closes down after executing ps -ejH in a fraction of a second (I can see it flash by). I can't get it to stay open. This is easy to do with the '-hold' option in xterm, so I'm hoping there's some little-known or clever command option for xfce4-terminal that does this as well.
Does exo-open get around the problem or is it the same deal?
Alternative solution might be to pipe ps' output into a pager like less.
No, exo-open just launches xfce4-terminal to execute ps -ejH, but it doesn't keep xfce4-terminal open. Same with piping the ps -ejH output to various commands.
However (Ta da!) this almost works (and it won't work with -e instead of -x):
xfce4-terminal -H -x ps -ejH
Problem is, the command doesn't complete and return me to the prompt. I get to see the process tree, but I can't act on it (e.g., kill a process). I have to close the terminal and re-open it.
What can I add to the command to finish ps -ejH and get a prompt? (Yes, I know I could do a script here, but it would be neat to do it just with terminal commands...)
Edit: I actually don't have to close the terminal, I can open a new tab and enter commands there, but it would still be good to do it in the ps tab.
Try this as paramters for your xfce4-terminal: "ps -ejH && /bin/csh"
Replace csh with your shell path. Keep the quotation marks.
Hi, M.O.S.
Thanks for the interesting idea, but with xfce4-terminal -e "ps -ejH && /bin/bash", the terminal appears but doesn't stay open.
Could you open a Terminal or Xterm, etc. and try that command from there. Maybe it's returning some error.
In xfce4-terminal, entering ps -ejH && /bin/bash executes ps -ejH and brings me back to a prompt.
If I launch xfce4-terminal with a panel launcher, either the plain command
xfce4-terminal -e "ps -ejH && /bin/bash"
ps -ejH && /bin/bash
with 'Run in terminal' checked gives me the 'now you see it, now you don't' flash-past.
[Logging off, maybe more tomorrow, many thanks]
How about just running Conky and always have it visible some where on the desktop? Sounds like a cleaner solution to what you'd like
Hi, s0ulslack.
Yes, conky is cleaner and prettier - if you have lots of screen real estate. I have a 13" laptop display running at 1280x800 px.
Normally I just do Ctrl+Alt+t (custom keyboard shortcut) to call up xfce4-terminal, then type in commands, and I still do that for most CLI jobs. As a newcomer to Xfce I thought I'd see how far I could push panel launching!
Anyway, xfce4-terminal -H -x ps -ejH does the job. Many thanks.
Hey, I had a similar problem, while trying to login to the terminal. If you run su in the terminal as you open the terminal, then you should have your problem solved. It worked for me, and I hope it helps.
Hi, Xfce_User81.
I don't think my reflexes are good enough to enter su in the terminal as it launches. It's only open for a fraction of a second!
lol. I must apologize. What I meant was for you to run su in terminal before you open. All you have to do is right-click the terminal icon in your system tray or go to your program launcher. There is a setting you can change to always run the command su in the terminal as it opens. Again, sorry for the lack of detail or clearity. Hope that helps.
Interesting idea. Are you saying I should just su to myself before running the command? (Otherwise I'd be switching to root, which requires a password, which defeats the purpose of a launcher that opens a terminal with the command running.)
I can't see how that would get around the problem, and when I try coupling the commands (and using the Run in terminal option), I get the usual flash-past of a terminal opening and closing in the blink of an eye. Can you suggest a syntax?
P.S. Have you read Richard Stallman's entertaining entry in info su?
Sorry, that it wouldn't work. It worked for me to just run su command in the terminal before I opened the window. Maybe the distribution you are using requires a different command, such as sudo. I am running FreeBSD. Sorry if I am wasting time here.
Hi, Xfce_User81.
No, no! Not wasting time! This forum is all about trying different things to see if they work. Many thanks for your suggestion, it was definitely worth trying. (And sudo also doesn't work...)
I have no idea if su can work, but you could try it with the -m option followed by your user, and the -c option for the command. Check your su man page in case your system has different options.
Hi, ManOfSteel.
man su says "If the target user has a restricted shell, this option has no effect" for the -m and -p options. No effect: terminal opens and closes.
I'm still trying to get my head around being logged in, then su'ing to myself...
Deja vu all over again. It looks like exactly this issue was raised and discussed 3 years ago on Ubuntu forums:
No fix there, either. It's curious that I can get the command to complete (i.e., and return me to the prompt) with xfce4-terminal "pre-opened", but not when I launch it with that same command.
Why not use bash magic?
ps -ejH
echo "Press any key to close!"
Hi, haarp.
No reason why I couldn't, but like I said in an earlier post on this thread, "Yes, I know I could do a script here, but it would be neat to do it just with terminal commands...". It's a tinkering instinct. At the moment my only script-by-panel-launch is an rsync. And for ps purposes I'm happy enough with xfce4-terminal -H -x ps -ejH, even though it doesn't complete.
Executing commands while switching users should be possible. The only restriction I know of, is when switching to UID 0, which requires that your user be a member of the administrative group (e.g. wheel). I think su itself is working in your case, but it's just doing the same thing as the other commands that you've tried so far and have failed.
But I guess switching to your own user is quite weird, yes.
Why don't you use Xterm (with -hold) just for that command alone?
This thread's getting so long it's easy to forget previous posts! In my 2nd one I said "I can't get it to stay open. This is easy to do with the '-hold' option in xterm, so I'm hoping there's some little-known or clever command option for xfce4-terminal that does this as well."
I actually like good old xterm, and would use it as default terminal except it doesn't have tabs.
Just to clarify my previous post. I misunderstood the situation. Late night caused my own confusion. Sorry for any confusion. Su didn't work for me in your case. Another issue I had problems with long ago.


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Back in February at the Toy Fair in London, Pocket-lint had a chat to a designer working for Zeon Tech who had devised a mini arcade cabinet for the iPhone. Called iAppCade back then, the concept was different from the existing iCade in that it didn't rely on Bluetooth to communicate with the handset.
Now that product has been released under the rejigged name of Arcadie. It's available through Firebox.com for £14.99 and Pocket-lint has got its mitts on one to have a play.
Although it is made of plastic, the Arcadie is well built and sturdy. There's a small joystick and two mini buttons and that's about all. Because it doesn't rely on Bluetooth to work, it doesn't need batteries, and you slot your iPhone (or iPod touch) into the cabinet, making it look far more authentic than rival products.
For starters, that means you get a tiny 4:3 screen as found on the original coin-op machines (albeit much smaller). iCade Jnr, for example, uses the full iPhone screen, so looks elongated.
Plus, slotting the iDevice into the unit adds stability. It feels like one complete gadget, rather than something resting on another.
Of course, that also means that the graphics on screen are tiddly, but every game available is still more than playable.
The way the Arcadie works is by features capacitive buttons on the inside of the cabinet, which touch the iPhone screen in different ways depending on the button presses or joystick movements. These tell the compatible applications what to do on screen and Bob's your uncle.
The benefit to this is that it will work without putting any further drain on your battery life above and beyond playing the game itself (Bluetooth applications can be sapping), although there is a downside.
The iCade Bluetooth control system uses an API that any developer can add to their existing app, therefore there are many titles out there that are compatible. Arcadie requires specific applications to be developed especially for it.
Currently, there are three, all based on popular retro arcade favourites. It doesn't take a genius to guess the inspirations for Blasteroids, Alien Invaders and Ping (Pong) and they all play well on the accessory. In addition, they are all available for download from iTunes absolutely free.
Zeon Tech also plans for three further games to be released soon; Planet Defender, Stacker (a bit like Tetris) and Invaders (a more accurate Space Invaders clone). And hopefully, they will not be the last.
Back at the Toy Fair, we were also told that the Arcadie (iAppCade) was compatible with MAME4All, the arcade emulator that was removed from the App Store but is still available for jailbroken devices. Not having one of those to hand, we haven't tried it, however.
To find out more information on the Arcadie, and check out new game releases, visit www.arcadie-arcade.com.
What do you think? Fancy a little arcade machine on your desktop? Let us know in the comments below...


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Flashback to 1989, and you'll recall the Mazda debuted the very first Miata under the lights of the Chicago Auto Show. Because of that, Mazda has had a tendency to debut many a special edition Miata at the Chicago expo, and this year will be no different.
Limited to just 450 units here in the Untied States, the 2012 Mazda MX-5 Special Edition takes the top-trim Grand Touring model a step further with a new black-only power retractable hard top – the first time a non-body colored hard top has been available – as well as new 17-inch gunmetal wheels, black exterior accents, black heated leather seats and piano black interior trim. Two new exterior colors – a special white and red – will be offered, and the car can be had with either the six-speed manual or six-speed automatic transmission.
Mazda makes no mention of powertrain upgrades for the MX-5 Special Edition, but the normally optional Premium and Suspension packages will come as standard equipment. This means buyers will be treated to goods like Bluetooth, Sirius satellite radio, Bilstein shocks and a sport-tuned suspension. Pricing and detailed specs will be released as part of next week's Chicago festivities.


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Memorial Day Sale: We Pay The Sales Tax | Shop Now
Memorial Day Sale: We Pay The Sales Tax | Shop Now
Constructed of black powder coated painted 16-gauge steel for heavy-duty security.Heavy duty color matching arm rests provide comfort while driving. Separate lockable security compartment holds your valuables. Includes dual adjustable front cup holders to fit all sizes of cups and bottles. Available in (11) Gray Denim, (15) Black Denim or (17) Spice Denim.
The quality seems fine for the price. I did have to trim the back support to fit the slight couture of the CJ floor. If I didn't it might rock from side to side a bit. Now it fits solid and holds the sun glasses, ammo, winch remote and more.
Great security console. Would recomend to all.
When I received this console I was very pleased as it looked very nice and seemed quite sturdy. I ordered it because it was the cheapest seemingly decent console and looked similar to one of the tuffy box consoles. This console fits very tightly between the front seats making it very difficult to keep the passenger seat belt in position after having anyone get in your back seat. Be very conscientious when tightening the bolts down because the bottom welds will beak and split the console open at the edges. Another issue was that one of the bolts it came with was too long so you'll have to improvise another one. I've had this for about a year now and the back of it is cracked at the welds so its open by about a centimeter. Over all its an okay console I went with out any console for nearly a year and I've got to say its just nice to be able to keep stuff somewhere in my Yj. Definitely going for one of the tuffy boxes next time regardless of the extra money I believe it's worth it.
How long is the console and how wide at its widest and longest points?
Asked by SDF from on
This Smittybilt Security Floor Console measures 22"L x 9"W x 12"H Thanks!
Answered by Craig R. from on
For 60 years Smittybilt has been fabricating aftermarket parts and today their products include Jeep tops, bumpers, lighting, winches and trail gear. Off-roaders count on the company's innovative parts like the original nerf bar side steps to equip their Jeeps for the trail and day-to-day driving. Pairing affordability without compromising quality is the hallmark of Smittybilt and the manufacturer's reputation carries over to products like its Overlander Series of tents, Adventure Boxes and SEMA award-winning magnetic trail skins for Jeeps. Smittybilt offers over 2,000 interior and exterior parts and accessories for 4x4s with multiple capabilities for jeepers of all levels. Shop Smittybilt Now
We Pay Your Sales Tax


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Monday, October 31, 2011
Kidney transplantation in patients with multiple myeloma - To do or not to do
Saturday, October 29, 2011
To buy or not to buy
A number of years ago, I was at a lecture given by a transplant surgeon from London. He was discussing the dangers surrounding living unrelated kidney transplantation and he told the story of a member of a royal family, of a country that will remain nameless, who had come to London to get a transplant from his cousin. The cousin did not speak any English and, in fact, spoke a very obscure dialect so the translators had been provided by the Prince rather than the hospital. The night before the operation, the transplant fellow was doing his rounds and stopped to talk with the cousin. By coincidence, he was from the same area as the donor and started talking with him. It turned out that the donor was a private in that nation's army and had no idea what he was doing there. Of course, the transplant was cancelled.
I was reminded of this by the case of Levy Izhak Rosenbaum (previously mentioned in a post by Nate) who pleaded guilty this week to three sample charges of organ trafficking. He was selling kidneys to wealthy Americans for over $100,000 each and allegedly paying donors in Israel around $10,000 for each kidney. He is likely to spend the next 20 years in prison.
Iran is currently the only country where it is legal to pay donors although it was legal in India until 1994. There are very short waiting lists in that country as a result although, as you might expect, there is very little intra-family donation because of the ready availability of organs from unrelated donors. The Declaration of Istanbul stated unequivocally that transplant tourism and organ trafficking are unethical and lead to exploitation of the poor but this certainly has not ended the debate. Last year, there were a number of posts on RFN on this very topic with some impassioned debate.
One of the key arguments in favor of allowing payment for donation is the lack of adverse outcomes for donors but many programs still do not monitor long-term outcomes, although it must be said that most published data suggests that it is relatively safe. However, any operation carries some risk and it is inevitable that a portion of these donors would die in any given year. Remember that donation carries no medical benefit for the donor.
This is a very difficult ethical topic and I don't know what the correct answer is. My own bias is that it should not be allowed and I think it would take a lot to convince me otherwise. This particular case is interesting because the concept of organ trafficking is usually discussed in the abstract in the US but this shows that it is certainly going on here and care must always be taken if there is any suspicion of money changing hands.
In a related case, 3 Brazilian doctors were convicted this week of removing organs from patients in a public hospital for use in an expensive private hospital. The patients, with the collusion of a neurosurgeon, were diagnosed with brain death and the doctors were convicted of murder. There were allegations of payments being made although these were never proven. The complexity of this topic is shown by the fact that it took 25 years for this case to come to a conclusion – the original operations occurred in 1986.
Friday, October 28, 2011
From the RFN Archives: Water treatment in dialysis- more than a Brita filter
1) water passes through filters for particle removal
2) it then passes over activated carbon, which removes chlorine and chloramines
3) next is a cation exchange resin that serves to "soften" hard water, i.e. exchange Ca and Mg for Na
4) then: reverse osmosis. Pressure is applied to the water and pushes it over a polyamide or cellulose acetate membrane. This process rids the water of organic matter, bacteria, and endotoxins.
5) next step: deionizers, resins that remove cations and anions.
6) water is then irradiated to kill any remaining pathogens.
7) then it is ultrafiltered to remove any remaining bacteria, viruses, and pyrogens.
Water is then continuously circulated to avoid stagnation, and siphoned off to different dialysis stations during treatment.
If you see the following signs in patients at a particular dialysis unit, consider the following water treatment problems:
Anemia- aluminum, chloramines, copper, zinc
Bone disease- aluminum, fluoride
Hemolysis- chloramines, copper, nitrates (3 C's from Nate's prior post)
Hypertension- calcium, sodium
Hypotension- bacteria, endotoxins, nitrates
Metabolic acidose- low pH, sulfates
Encephalopathy- aluminum
Nausea/vomiting- bacteria, endotoxins, low pH, nitrates, sulfates, zinc
Many thanks to Dr Coyne for the shameless pirating of several of his slides.
Originally posted by Lisa Cohen
Wednesday, October 26, 2011
Tumor lysis or tubular lysis?
A patient presented to the outpatient service with progressive renal insufficiency and sub-nephrotic range proteinuria. He had a long history of CMML with few blasts in his bone marrow aspirate but a peripheral white cell count that was persistently in the 40s. There are many ways in which leukemia can cause renal dysfunction the commonest being infiltration of the kidney, tumor lysis, acute or chronic TMA and toxicity related to the treatment including chemotherapy and radiotherapy. It was not initially obvious what the specific cause of the renal impairment was in this case so he was referred for a renal biopsy.
CMML (chronic myelomonocytic leukemia) is classified as a myelodysplastic/myeloproliferative disorder as it has characteristics of both and primarily is a disease of the elderly. It is characterized by the presence of increased number of peripheral monocytes and usually causes renal damage through infiltration or amyloid deposition. Under normal circumstances, monocytes and macrophages produce lysozyme. This protein is stored in these cells and used to lyse the cell walls of certain bacteria. In some patients with CMML, there is marked overproduction of lysozyme some of which is released into the circulation. It is subsequently filtered by the glomerulus and then reabsorbed by proximal tubular cells where it causes direct toxicity. There may also be an effect related to the fact that it is positively charged thus leading to potassium wasting. Interestingly, previous case reports have found that lysozyme is the predominant protein found in the urine of patients with this disorder and measuring urine and serum lysozyme levels could obviate the need for a renal biopsy in some cases.
The figure above is taken from a case report of lysozyme nephropathy, showing the normal appearing glomeruli, degenerative tubules and many protein reabsorption droplets on EM. Panel C shows strong staining for lysozyme in proximal tubular cells by immunohistochemistry. Treatment is generally supportive and aimed at treating the underlying disorder, thus reducing the production of lysozyme
Monday, October 24, 2011
Bactrim prophylaxis with high-dose steroid use?
This is a question we face quite often in the Nephrology clinic when we are commencing patients on high dose steroids for glomerular and other systemic inflammatory diseases.
I came across a couple of interesting retrospective studies while trying to find some evidence to help guide the decision-making process.
The first study analyzed 116 cases of pneumocystis pneumonia in non-HIV infected patients. The major common exposure was steroid treatment in the month preceding presentation (90.5% of patients) – the median dose was equivalent to 30mg prednisone for a median of 12 weeks before presentation.
The second reported risk factors in 41 cases in a French centre. Mortality was 29%; 85% had received steroids at a median daily steroid dose equivalent to 15mg prednisone. Only 17% had received prophylaxis.
The third used a matched case-control type analysis in patients with SLE – they reported 15 cases of pneumocystis infection; risk factors for infection compared to 60 matched controls included higher disease activity, renal involvement and higher mean cumulative steroid dose (49 vs 20mg/day; p<0.01).
Finally a Cochrane review of RCTs of prophylaxis against PCP (versus none/placebo/non-PCP agents) suggested that prophylaxis was warranted when the risk of PCP infection is higher than 3.5% for adults – the authors suggested this included the following groups – "recipients of solid organ or allogeneic bone allografts for the first 6 months after transplant and, for the latter, throughout the period of immunosuppression, as well as in patients with acute lymphoblastic leukemia and Wegener granulomatosis"
There are a number of factors to be considered when trying to answer this difficult scenario – the dose of steroids used, the duration of treatment, use of other immunosuppressive drugs (i.e. the net state of immunosuppression), medical co-morbid conditions and infection history.
Many experts suggest prophylaxis for patients with rheumatological diseases requiring treatment with ≥20mg prednisone for greater than one month when used in combination with another immunosuppressive drug. Overall the pros and cons of PCP prophylaxis must ultimately be judged on a case-by-case basis.
Tuesday, October 18, 2011
From the RFN Archives: The Ponticelli Protocol
However if we use the evidence available to us, there are certain protocols which are specific to certain diseases. Not everything responds to steroids--for example, while it is reasonable to attempt a course of steroids alone for FSGS, there is good data to suggest that steroids alone does NOT have an effect in individuals with isolated hematuria from IgA Nephropathy.
One of the landmark protocols for glomerular disease is the so-called "Ponticelli Protocol", used in the treatment of idiopathic membranous nephropathy. The 1992 NEJM paper describes the randomization of a group of patients with biopsy-proven membranous nephropathy to one of two regiments: (a) a 6-month course of steroids alone, or (b) a 6-month course of alternating monthly steroids and chlorambucil. The rate of remission was significantly lower in the steroids/chlorambucil group, thus giving rise to the first effective therapy for this disease.
In present day nephrology (at least at the fellowship program at which I am training) chlorambucil is seldom used--too many side effects (e.g. bone marrow suppression)--and instead a different cytotoxic agent--namely cyclophosphamide (Cytoxan) is used. A typical regimen (the "modified Ponticelli protocol", JASN 1988; 9:444) is shown below:
Months 1, 3, and 5: Solumedrol 1000mg iv daily x 3 days then prednisone 0.4 mg/kg/d x 27 days.
Months 2, 4, and 6: CTX 2.5mg/kg PO daily x 30 days.
Originally posted by Nate Hellman
Monday, October 17, 2011
Heavy Chain Deposition Disease
As I passed the doorway the attending at the head of the group spun on his heal, looked at me dramatically and asked, "what illness was that man suffering from?"
I wracked my brain, "had his hands looked arthritic? Did he have a chest tube?" I had no idea and shrugged.
"That," the attending declared, "was Heavy Chain Disease!" The team chuckled and moved on and I sighed and tried to remember what Heavy Chain Deposition Disease (HCDD) was. In the October issue of AJKD there's a nice case series of HCDD that had me reliving that day of internship.
HCDD falls under the banner of Monoclonal Ig Deposition Diseases (MIDD). There are three major types of MIDD, Light Chain deposition disease (LCDD), Light and Heavy Chain Deposition Disease (LHCDD) and HCDD. In the July NephSap on Renal Pathology (which is a must read if you haven't seen it yet) it's stated that 80 to 90% of MIDD cases are LCDD, 10 to 20% are LHCDD and less than 5% are HCDD with just 27 cases identified by the AJKD authors.
HCDD is characterized by glomerular and tubular basement membrane deposition of monoclonal heavy chains without associated light chains. In terms of the types of Ig that have been described IgG related disease has been most commonly reported with rare reports of IgA and IgM.
Clinically most patient's with HCDD present with hypertension, progressive renal failure, nephrotic range proteinuria and microhematuria. In the AJKD article the authors note that a conclusive diagnosis of a plasma cell dyscrasia was made in all cases of IgA related disease but in just 19% of IgG disease. They speculate that the reason for this is that the conformational abnormality of the monoclonal heavy chain in IgG disease is such that it has a very high avidity for renal parenchyma so that even small quantities produced by a clinically undetectable population of cells is enough to cause HCDD. The single case report of IgM disease did not have an associated plasma cell dyscrasia.
The predominant pattern seen on light microscopy in HCDD is nodular glomerulosclerosis and of note all the cases of IgA related disease additionally had crescents. Nodular glomerulosclerosis has its own interesting differential diagnosis that has been previously reviewed on RFN. Check out the nice table below on the subject from JASN.
Immunofluorescence is negative except for occasional complement deposition along with the pathologic heavy chain and electron microscopy shows fine, granular, punctate electron dense deposits that lack fibrillary structure (see Emily's great review of Organized Deposition Diseases for more on fibrillary deposits). The deposits are seen in the inner aspect the of the GBM, mesangium, outer tubular basement membranes and vessel walls.
Now if the attending hits you with a bad pun post call, you'll 1) be ready for the pun and 2) be ready to dazzle and amaze with knowledge about HCDD.
Thursday, October 13, 2011
MDIBL - ASN reunion
Date for your diary
Dr Zeidel and the MDIBL crew wish to invite all previous attendees to the Second Annual Reunion of the Mount Desert Island Biological Laboratory National Course for Renal Fellows.
This is a great opportunity for anyone attending Kidney Week to catch up and network with former students and faculty of this wonderful course. More information in the course itself can be found here.
The details of the reunion are below:
Friday, November 11, 2011
6:45 p.m. – 7:45 p.m.
Philadelphia Marriott Downtown
Rooms 309/310
This reunion is sponsored by the American Society of Nephrology.
Monday, October 10, 2011
Enter the Chimera
Nate posted on the Mass General program for combined kidney and bone marrow transplants back in 2009 with reference to the original NEJM report from 2008. This past week in NEJM our fellowship director, John Scandling along with the transplant and basic science groups, reported on the followup of the initial 12 patients to undergo the protocol here at Stanford.
The protocol is incredible. Patients receive 10 doses of total lymphoid irradiation targeted to the lymph nodes, spleen, and thymus, and five doses of rabbit antithymocyte globulin during the first 10 days after kidney transplantation readying the recipient immune system for donor immune cell engraftment. Donor CD34+ cells and a defined dose of T cells are then given to the kidney recipient on day 11 in order to create the new "chimeric" bone marrow.
All patients get MMF for 1 month and cyclosporine for at least 6 months. Cyclosporine is discontinued as long as persistent chimerism can be demonstrated and there is no clinical or biopsy evidence of kidney rejection or graft-versus-host disease.
Seven of the initial 12 patients are now completely off immunosuppressant drugs without clinical or biopsy evidence of kidney rejection. One patient, who was off immunossupresant drugs for three years died suddenly while exercising four months after a myocardial infarction. Four patients continue to receive immunossupresant drugs because of recurrence of FSGS in one and episodes of rejection during the tapering of cyclosporine in the others.
The original protocol was applied to folks with perfectly HLA matched donors. These patients likely would have had excellent outcomes and allograft survival independent of chimerism but the protocol allows them to avoid the risks, side effects, expense and adherence issues that come with long term oral immunosupression. Patients with one mismatched HLA haplotype living donors have now entered the program and hopefully will be able to experience similar benefits.
Saturday, October 8, 2011
Resistant Hypertension: breaking the barrier
Friday, October 7, 2011
Shedding some light on chronic inflammation
Recent work has implicated bacterial lipopolysaccharide (LPS or endotoxin), a glycolipid found in the outer membrane of gram negative bacteria, in this process. (The potency of LPS as a pro-inflammatory stimulus is detailed in this extraordinary case report from the NEJM archive)
Previous work in patients with congestive cardiac failure (reviewed here) has demonstrated that relative underperfusion of the gut results in leakage of LPS from the GI tract into the circulation. A group of UK investigators analogised this situation to the haemodynamic perturbations seen in haemodialysis sessions and used this as a starting point to investigate the concentration of circulating LPS in CKD patients.
They found that endotoxemia (i.e. circulating LPS concentrations) :
- tended to increase with worsening CKD stage
- showed a 6-fold increase in patients on dialysis
- tripled at the initiation of dialysis
So should we be giving our most haemodynamically unstable dialysis patients antibiotic treatment, or selective gram negative gut decontamination or polymyxin B haemadsorption instead of dialysis? Well, my thought is that individually tailored dialysis prescriptions to reduce CV stress during dialysis sessions are likely to be a good start in reducing LPS translocation and potentially decreasing the sequelae of this. I also note that the same group have just published a paper suggesting that plain (and good) old aggressive anti-hypertensive therapy might be a good option too.
Thursday, October 6, 2011
SLE and Dialysis
Wednesday, October 5, 2011
Urge Congress to Support the Immunosuppressive Drug Coverage Bill
Lifetime immunosuppressive drug coverage is part of protecting the health of kidney transplant recipients and under current medicare rules this coverage only extends for 36 months post transplant. During this period medicare covers 80% of immunosuppressant drug costs, while patients and or insurers cover the rest. Patients who qualify for Medicare by being over the age 65 and or disabled are exempt from these limitations.
The "Comprehensive Immunosuppressive Drug Coverage for Kidney Transplant Patients Act of 2011" will help patients who receive a new kidney to keep it healthy by extending immunosuppressive drug coverage past the 36 month cut off. This legislation will help save lives and is an effective use of taxpayer dollars as it avoids the madness of potentially allowing a transplant to fail followed by guaranteed coverage of dialysis.
ASN has a nice pre-composed email that you can edit and send to your members of Congress if you are interested in supporting the bill.
Sunday, October 2, 2011
Renal allograft rupture
Renal allograft rupture is a rare, but life-threatening, complication of renal allograft placement. It most often occurs in the first two weeks post-transplant and usually requires immediate surgical intervention. The classical presentation is with sudden onset of pain at the graft site, shock and oliguria.
The pathophysiology appears to be secondary to increased intra-renal pressure and and associated secondary injury. The increased pressure can result in splitting of the capsule, usually along the longitudinal outer border, with resultant haemorrhage.
The main putative aetiologies have been described in many case series including this one, and include acute rejection, acute tubular necrosis, renal vein trombosis, increasing PRA, increasing age, biopsy of the graft and infection.
In my quick analysis of published cases series over the last ten years, the crude incidence of RAR appears to be around 1.11%. Of these cases, the majority were caused by acute rejection (55.8%), ATN (34.7%) and renal vein thrombosis (7.4%).
Immediate management involves supportive care and resuscitation, followed by containment of the ruptured area by surgical means or sometimes graft removal. The literature supports an atempt at graft salvage, with many successful outcomes reported to date. Thankfully it remains a relatively rare diagnosis, but definitely one we should all be aware of.


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Amy Daniels started her teaching career at the Lilla G. Frederick in 2003. She was fresh out of college and moved here from Pennsylvania with a degree in health and physical education with a concentration in sports administration.
I recently met with Ms. Daniels to talk about the importance of athletic programs in public education. "Sports are an essential part of life for people of all ages. Ms. Daniels says, "Sports teach our young people the value of teamwork, cooperation, discipline, and commitment." In 2003 there weren't any sports programs offered at the Frederick. However, in the past 10 years Frederick has built one of the most successful middle school athletic programs in Massachusetts; there are currently 12 sports programs at the school. "We have coaches who are consistent, clear, disciplined. We all work together as an athletic department to help our student athletes work hard academically, and to instill pride within each and every student athlete," says Daniels.
"What role did athletics play in your life?" I asked. She noted that sports allowed her to achieve dreams she never thought possible. She struggled academically and came from a troubled household, but playing sports gave her self-confidence and provided an outlet where she learned how to overcome her obstacles. "Playing sports gave me something to like about myself. I was filled with hatred and negativity because of my family life. It also taught me the importance of time management, commitment, dedication and pride," says Daniels.
She graduated high school on an athletic scholarship that provided her the financial means to go to college. "Sports provided me with the foundation I needed to represent myself and my community in two International Rugby Board World Cup events!"
Eleven years later she finds herself still at the Frederick. Being a physical education teacher in Boston Public Schools has been a great privilege and honor for her. Ms. Daniel prides herself on the relationships she builds with her students in the classroom and on the court. "I have often found Boston Public Schools to possess some of the most profound students." Her students see her as a successful international female athlete who has chosen to work in Dorchester. She is constantly asked why she decided to stay with BPS. Her reply: "Well, someone has to teach you what you need to know to fill my shoes."
Amy Daniels never thought that when she walked into the Frederick building for her interview that it was going to change her life completely. "I quickly found a place for me underneath this roof that I proudly say is my home."


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Cops: Man asleep in running car -- atop snowbank -- charged with DUI
A Bridgeport man, found sleeping in his car that ended up on a Grasmere Avenue snowbank, was charged early Saturday with driving under the influence.
Orlando Delgado, 23, of Dayton Road, Bridgeport, was also charged with failure to drive right and possession of less than a half-ounce of marijuana.
A Grasmere Avenue resident called police just before 2 a.m. Saturday to report the car atop a snowbank. She said the driver had gotten out of the car, was walking around and then got back in the driver's seat.
When police arrived, the car's engine was running, the headlights were on and the front bumper had fallen off the vehicle. Delgado, the report states, was asleep, reclining in the driver's seat. Officers woke up Delgado, and said there was a strong odor of alcohol on his breath. He was unsteady on his feet getting out of the car, and failed field sobriety tests, according to the report.
A small packet of marijuana was found on the car's floor, police said.
At police headquarters, Delgado refused to submit to a breath test, according to the report. He was released on a $100 bond and is scheduled to appear March 11 in Bridgeport Superior Court.


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Getting a bit of an early start and catching up with some news we didn't discuss yesterday.
* In terms of raw cash, the movies had a record March this year, largely thanks to those inflated, and then extra-inflated, ticket prices for "Alice in Wonderland" in 3-D. We'll see how long this lasts.
* RIP Corin Redgrave, of one of the world's great acting families.
* Reading this Nikki Finke item about what sounds like the increasingly fraught auction of MGM, it really does make it seem like a million years ago when MGM was the absolute epitome, for better and for worse, of Hollywood power.
* I'm breaking a confidence here with this super-secret Twitter leak by Jon Favreau, but it appears that Harrison Ford will be in "Cowboys and Aliens."
* Universal, which hasn't exactly been rolling in cash lately, has pulled the plug on "Cartel." It would have been a remake of the fact-based Italian mafia thriller from 1993, "La Scorta," set admidst Mexico's drug wars. Josh Brolin was set to play the lead. Mike Fleming doesn't specifically mention insurance or the cost of security, but considering the topic and what's been going in throughout Mexico — apparently including Mexico City where the film was to be shot — it must have been through the roof.
* Master cinephile blogger Dennis Cozzalio checks in and brings word of some cool film fests.
You can follow us on Twitter @moviebuffs and on Facebook as well.
Posted in: Actors, Documentaries, Movie Comedies, Movie Dramas, Movies, News
Tags: 3-D, ACORN, Albert Maysles, Alex Robinson, Alice in Wonderland, Andrew Breitbart, Billy Ray, Breach, Cartel, Clint Eastwood, Corin Redgrave, David Wain, Dennis Cozzalio, Grey Gardens, Grizzly Man, Headlines, Josh Brolin, Kick Ass, La Scorta, Masters of War, Mexico, MGM, Oliver Stone, Primary, Roger Ebert, Role Models, Russell Brand, Shattered Glass, Soul Power, The State, Timothy Treadwell, Too Cool to be Forgetten, Werner Herzog, Wet Hot American Summer, Wondercon


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A judge ruled accused terror mastermind Khalid Sheik Mohammed will be allowed to wear camouflage during his trial on charges he helped orchestrate the Sept. 11, 2001 attacks.
Mohammed and one of his co-defendants, Walid bin Attash, had wanted to wear camouflage clothing in the courtroom at their May arraignment, apparently to portray themselves as soldiers, but the prison commander refused to allow it. The judge ruled at a pre-trial hearing Tuesday they could wear some camouflage items as long as they were not U.S. military uniforms.
Mohammed wants to dress like a "prisoner of war," said his lawyer, Army Capt. Jason Wright, and should be allowed to "wear the same type of uniform he wore while fighting for the U.S.-supported Mujahedeen in Afghanistan and in Bosnia," he said.
Defense lawyers have said that the clothing restrictions had been a factor that led to their protest at their May arraignment, when the men ignored the judge's questions and wouldn't use the court's translation system.
This week, the men have all appeared in traditional loose fitting traditional tunics, vests and hats that they chose to wear.
Three of the defendants took the judge up on his offer to let them skip their military tribunal Tuesday and the proceedings went on without them.
Mohammed was not in the courtroom while attorneys delved into a dense debate on legal motions, including rules for handling classified evidence at trial and what kind of clothing would be allowed.
The 47-year-old Mohammed, who has previously said he conceived and orchestrated the Sept. 11 attacks, gave no reason for sitting out the hearing. But on Monday, he dismissed the military tribunal with scorn, saying "I don't think there is any justice in this court."
Authorities have portrayed the other defendants as Mohammed's underlings, who provided logistical and other help to the Sept. 11 hijackers. All five face the same charges, which include terrorism and murder, in what is considered one of the most significant terror prosecutions in U.S. history. They all could get the death penalty if convicted at a trial that is at least a year away.
KSM Can Wear Camouflage During 9/11 Trial: Judge
Self-professed 9/11 mastermind wants to dress like a "prisoner of war," his lawyer says
A judge ruled accused terror mastermind Khalid Sheik Mohammed will be allowed to wear camouflage during his trial on charges he helped orchestrate the Sept. 11, 2001 attacks.


text: Dolfan in NYC 14,557 Posted October 30, 2018 You know what? For what was supposed to be a big emotional speech, Seth really just comes across as a whiner. And like everything he was saying just was reaffirming all the bad things Dean thought about him. #TeamDean 1 Share this post Link to post Share on other sites


text: Keeping your homebrewing equipment clean and sanitary is one of the most important, if not the most important, aspect of homebrewing. Brewery cleaning and sanitizing solutions such as PBW, Star San, Saniclean, and Liquid Line Cleaner are all essentials in keeping your homebrew equipment clean and sanitary, preventing wild yeast and bacteria from spoiling a batch. We encourage you to always have enough of these solutions on hand, and never skip any of these steps!


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Votre titre Audible gratuit
Bryson documents the efforts of earlier scholars, from academics to eccentrics. Emulating the style of his famous travelogues, Bryson records episodes in his research, including a visit to a bunker-like basement room in Washington, D.C., where the world's largest collection of First Folios is housed.
Bryson celebrates Shakespeare as a writer of unimaginable talent and enormous inventiveness, a coiner of phrases ("vanish into thin air", "foregone conclusion", "one fell swoop") that even today have common currency. His Shakespeare is like no one else's: the beneficiary of Bryson's genial nature, his engaging skepticism, and a gift for storytelling unrivaled in our time.
Autres livres audio du même :
Ce que les membres d'Audible en pensent
- Crystal
- 24/02/2013
Unexpected Findings in a Quality Bryson Book
There's not much that can shock me about Shakespeare theories. I have a BA in English Literature. I've read all the plays, sonnets, even the ones suspected to be by Shakespeare.
It seemed an odd topic for beloved Bryson to tackle and I was curious about his angle on it. I was pleasantly surprised, "What do we really know about the bard?" he asks in the first chapter.
This was a refreshing and lively investigation into what's real and what's dreamed about one man's life. Solid topics, using all types of research from court records to paintings, Bryson gives a new eye on an ages old mystery. In the process, we learn about how many things have simply been made up by well meaning researchers for the past four hundred years!
I found myself wishing there was more. I loved it.
18 personnes ont trouvé cela utile
- Charles L. Burkins
- 30/11/2007
Too Little, Too Short
Bill Bryson's voice (both actual and literary) shine through in this short work, detailing what is known and knowable about William Shakespeare. Because little is known about Shakespeare, this book has less of the amusing anecdotes that make books like "In a Sunburned Country" such a delight. It's quite frustrating to realize that we know so little about a figure so important to English literature. Still it is an interesting exposition on an interesting man, or rather, what we expect is an interesting man. The audiobook it self is only a little over 5 hours long, but (as of November 2007) there is an interview with Bryson appended on end for another bit. I liked it, but then I expect that I would enjoy Bryson writing about asparagus. The chapter where he discusses the various theories about Shakespeare not actually writing the plays of Shakespeare is the best part; but there the book ends. In the end it is a barely satifying book because of the paucity of the material, but it is a book that is well written and narrated.
34 personnes ont trouvé cela utile
- Cathleen
- 22/03/2009
A Walk in the Forest Arden
My first exposure to Bill Bryson was A Walk in the Woods and I enjoy it still. Shakespeare is a different book -- more journalism than recollection, but it is extremely enjoyable and a good "listen" -- the chapters lend themselves to logical breaks, etc. And it is very amusing!
All of the historical detail is fascinating, and makes one wonder how we ever got the folio version of the plays at all. Probably the most interesting part for me was the debunking of all the "He didn't write the plays" theories.
Very enjoyable.
11 personnes ont trouvé cela utile
- Cather
- 09/12/2007
Bryson does it again...
Bryson admits up front that we know practically nothing about Shakespeare, but proceeds to tell what we do know, and how we know it, about the Bard himself, London, and the theatre world at the time. And he does it in classic Bryson style, finding the humor in everything.
And clearly, he's having fun reading it. He should... it's a fun book.
15 personnes ont trouvé cela utile
- Catherine
- 24/01/2012
Don't know much about Shakespeare
Bill Bryson talks as much about what we don't know about Shakespeare (or Shacksper or Shakspere, etc.) as what we do know. It is informative in a negative sort of way, with digressions on Shakespeare scholars, life and theater in the Elizabethan and Jacobian ages, and a bit about who else might have written the plays. I recommend it.
5 personnes ont trouvé cela utile
- Joshua Kim
- 10/06/2012
Concise and Wonderful
The world, or at least my world, needs more high quality concise books. Bryson's new Shakespeare, from the Eminent Lives Series, is one of the genres better examples.
The Modern Library Chronicles is another imprint with some excellent texts. To quote from their page:
"Modern Library Chronicles feature the world's great historians on the world's great subjects. Lively, accessible, and brief (most under 150 pages), these authoritative short histories are designed to appeal to general readers as well as to students in the classroom".
10 personnes ont trouvé cela utile
- Andy Spooner
- 25/07/2009
Very enjoyable in the typical Bryson style
This one is more in the historical vein of "Mother Tongue" or "Made in America" (as opposed to memoirs like "In a Sunburned Country" or "A Walk in the Woods"). Not as laugh-out-loud funny as his memoir-style books, but entertaining and fascinating, I thought.
3 personnes ont trouvé cela utile
- En vino veritas
- 30/08/2015
Perfect biography for school
My 7 th grade son has taken an interest in Shakespeare over the last school year and during our travel to London this summer. We were looking for a biography for summer reading requirements that was detailed, yet not such a large volume. This was perfect. We both enjoyed the Kindle and Audible version, and having been in so many of the places recently, including a performace at The Globe, it was like reliving all of the tours we had just taken. The thorough investigation and accumulation of facts regarding what we know, and what we don't know, was both digestable and intriguing for my son. It left him begging for a trip to the Folger Shakespeare Museum not far from us in Washington, DC. Thank you!
2 personnes ont trouvé cela utile
- Mau Mau
- 08/04/2015
Humorous & Accessible
Bill Bryson narrates his own humorous review of Shakespeare's life and the scholarship that's grown up around it. Bryson's reading is staccato and a bit dry at first, but I warmed to it over time. This is not a book for scholars or even serious students of Shakespeare. It's a funny look at the man who has affected so much and about whom so little is known. That said, Bryson appears to have done his homework. I learned enough to feel inoculated against silly conspiracy theories on the one hand or purist dogma on the other. Definitely recommended
2 personnes ont trouvé cela utile
- Tad Davis
- 19/02/2020
Short, sweet, and accurate
This book — part travelogue, part collection of interviews — is actually a handy little biography of Shakespeare. Bryson is an amateur when it comes to Shakespeare, but as a writer he's a consummate professional: he's read the right books (Samuel Schoenbaum, G Blakemore Evans) and he's talked to the right people (Stanley Wells, Georgiana Ziegler), and he's assembled the results in an entertaining and accessible way. He narrates his own book in a charming, maybe slightly less than conversational voice.
One of the things I like about the book is that brief as it is, it doesn't focus relentlessly on Shakespeare alone. Bryson takes the time to look to the right and the left of his subject, and his book is full of fascinating and little-known details about the period. (Little known by me, at any rate.) The last chapter is a cheerful takedown of the misguided idea that someone other than the glover's son from Stratford wrote the plays. The book concludes with a brief interview with the always-enthusiastic author. (My favorite question: "Do you think we'll ever find the play Love's Labours Won?")
Short and sweet, accurate, deeply interested in his subject.... if you want to extend your knowledge of Shakespeare, start here.
1 personne a trouvé cela utile
- Nina Adam
- 19/02/2019
Love it!
I had already read the book, and then decided to get the audiobook as well, because I like it so much, and because it contains so much information that you can listen to it many times. even though Bill Bryson is of course not a professional speaker, I really like the way he reads his books.
1 personne a trouvé cela utile


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Note: The January meeting is scheduled only if requested and authorized at the December meeting.
As specified by the Rules and Procedures of the Faculty, the University Faculty meets regularly on the Monday next following the formal Opening Exercises in September and thereafter on the first Monday of every month during the academic year except when this falls in recess, in which case the Faculty meeting is on the first Monday after recess; provided however, that, unless the Faculty at its September and its December meetings votes otherwise, no regular meeting is held in October and January. The regular hour of the meeting is 4:30 p.m. The meetings are held in Nassau Hall.
A statement of any item that is to be included on the agenda of a Faculty meeting must be delivered, in writing, to the Office of the Clerk of the Faculty by Wednesday noon, two weeks prior to the scheduled meeting. Any related material which is to be circulated to the Faculty with the agenda must be in the Clerk's office by noon of the Wednesday following the Monday, two weeks prior to the scheduled meeting. The deadline for receipt of material for this meeting is Wednesday, December 18, 2019.