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Akt Inhibitor MK2206, Lapatinib Ditosylate, and Trastuzumab in Treating Patients With Locally Advanced or Metastatic HER2-Positive Breast , Gastric, or Gastroesophageal Cancer That Cannot Be Removed By Surgery
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT01705340
Recruitment Status : Terminated
First Posted : October 12, 2012
Last Update Posted : September 30, 2013
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|Adenocarcinoma of the Gastroesophageal Junction HER2-positive Breast Cancer Male Breast Cancer Recurrent Breast Cancer Recurrent Esophageal Cancer Recurrent Gastric Cancer Stage IIIC Breast Cancer Stage IIIC Esophageal Cancer Stage IIIC Gastric Cancer Stage IV Breast Cancer Stage IV Esophageal Cancer Stage IV Gastric Cancer
|Drug: Akt inhibitor MK2206 Biological: trastuzumab Drug: lapatinib ditosylate Other: laboratory biomarker analysis
|Phase 1
I. To define maximum tolerated dose (MTD) and the dose-limiting toxicities (DLT) of MK-2206 (Akt inhibitor MK2206) in combination with trastuzumab and lapatinib (lapatinib ditosylate) in adult patients with locally advanced or metastatic HER2-positive breast or gastric cancer; two schedules of lapatinib administration will be examined-continuous daily dosing and pulsatile dosing.
I. To provide preliminary assessment of the safety and tolerability of MK-2206 administered in combination with epidermal growth factor receptor (EGFR)/HER2 blockade via trastuzumab and lapatinib in adult patients with a locally advanced or metastatic HER2-positive breast or gastric tumor.
II. To explore the anti-tumor activity of MK-2206 in combination with trastuzumab and lapatinib in patients with advanced HER2-positive solid tumor.
I. To correlate the anti-tumor activity of MK-2206 in combination with trastuzumab and lapatinib in HER2-positive solid tumor patients with phosphoinositide 3-kinase (PI3K) pathway activation events, e.g., phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) or phosphatase and tensin homolog (PTEN) and other related gene mutations and expressions; to compare the HER2 and PI3K-PTEN mutation status of the primary tumor to metastatic tumor biopsy when available.
OUTLINE: This is a dose-escalation study of Akt inhibitor MK2206 and lapatinib ditosylate.
Patients receive Akt inhibitor MK2206 orally (PO) on days 1, 8, and 15; lapatinib ditosylate PO once daily (QD) on days 1-21 or on days 1-3, 8-10, and 15-17; and trastuzumab intravenously (IV) over 30-90 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up for 4 weeks.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|60 participants
|Intervention Model:
|Single Group Assignment
|None (Open Label)
|Primary Purpose:
|Official Title:
|A Phase I Study of MK-2206 in Combination With Trastuzumab and Lapatinib in HER2-Positive Breast and Gastric Cancer
|Study Start Date :
|September 2012
|Actual Primary Completion Date :
|May 2013
Experimental: Treatment (MK2206, lapatinib ditosylate, trastuzumab)
Patients receive Akt inhibitor MK2206 PO on days 1, 8, and 15; lapatinib ditosylate PO QD on days 1-21 or on days 1-3, 8-10, and 15-17; and trastuzumab IV over 30-90 minutes on day 1. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.
Drug: Akt inhibitor MK2206
Given PO
Other Name: MK2206
Biological: trastuzumab
Given IV
Other Names:
Drug: lapatinib ditosylate
Given PO
Other Names:
Other: laboratory biomarker analysis
Optional correlative studies
- MTD of Akt inhibitor MK-2206 and lapatinib ditosylate in combination with trastuzumab determined by dose limiting toxicities as measured by the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) Version 4 [ Time Frame: 21 days ]Described by frequency and grade, by course and over all courses, with the maximum grade over all courses used as the summary measure per patient.
- Median progression free survival (PFS) [ Time Frame: Up to 3 years ]Estimated using Kaplan-Meier estimates along with 95% confidence intervals.
- Median and range of duration of response [ Time Frame: Up to 3 years ]Estimated using Kaplan-Meier estimates along with 95% confidence intervals.
- Overall response rate (ORR), evaluated by the Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 [ Time Frame: 21 days ]Calculated and presented with 95% confidence intervals. Kaplan-Meier methods or the Chi-square test will be used to assess whether PI3K-PTEN mutation status of metastatic tissue is correlated with PFS or ORR. In addition, comparisons of the HER-2 status and PI3K-PTEN mutation status of the primary tumor will be compared with that from metastatic tissue using paired tests, such as the Mc Nemar's Chi-square test.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years and older (Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Patients must have histologically confirmed HER2-positive invasive breast, gastric, or gastroesophageal carcinoma that is locally advanced and unresectable or metastatic and for which standard curative or palliative measures do not exist or are no longer effective; HER2-positive is defined as HER2 overexpression and/or amplification as determined by immunohistochemistry (3+) or fluorescence in situ hybridization (FISH) (>= 2.0)
- Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as >= 20 mm with conventional techniques or as >= 10 mm with spiral computed tomography (CT) scan
- Patients may have previously received trastuzumab or lapatinib as part of a regimen in the adjuvant or metastatic setting with evidence of progression
- No restriction on prior chemotherapy regimens for advanced stage disease; no restriction for prior hormonal therapy
- Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%)
- Life expectancy of greater than three months
- Left ventricular ejection fraction (LVEF) by multi-gated radionuclide angiography scan (MUGA) or echocardiogram (ECHO) at or above the lower limit of normal of 50%
- Leukocytes >= 3,000/mcL
- Absolute neutrophil count >= 1,000/mcL
- Platelets >= 100,000/mcL
- Total bilirubin within normal institutional limits
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamic pyruvate transaminase [SGPT]) =< 2.5 X institutional upper limit of normal
- Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- The effects of MK-2206 on the developing human fetus are unknown; for this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately
- Patients must be able to swallow whole tablets; nasogastric or gastrostomy (G) tube administration is not allowed; tablets must not be crushed or chewed
- Ability to understand and the willingness to sign a written informed consent document
Exclusion Criteria:
- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier; if the patient has residual toxicity from prior treatment, toxicity must be =< grade 1
- Patients who are receiving any other investigational agents; no concurrent use of endocrine therapy is permitted; patients on bisphosphonates or denosumab for bone metastases or osteopenia/porosis are considered eligible
- Patients with active brain metastases requiring radiation should be excluded as they may develop progressive neurologic dysfunction that would confound the evaluation of neurologic and other adverse events; patients with stable brain metastases (mets) (> 6 months without change in steroids or seizure medications) will be considered eligible
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to MK-2206, trastuzumab, or lapatinib
- Patients receiving any medications or substances that are inhibitors or inducers of cytochrome P450 3A4 (CYP450 3A4) are ineligible
- Preclinical studies demonstrated the potential of MK-2206 for induction of hyperglycemia in all preclinical species tested; patients with diabetes or in risk for hyperglycemia should not be excluded from trials with MK-2206, but the hyperglycemia should be well controlled on oral agents or insulin before the patient enters the trial; patients with poorly controlled diabetes with hemoglobin (Hgb)A1C > 9% will be excluded
- Preclinical studies indicated transient changes in corrected QT interval (QTc) interval during MK-2206 treatment; prolongation of QTc interval is potentially a safety concern while on MK-2206 therapy; cardiovascular baseline QTc > 480 msec will exclude patients from entry on study
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study because MK-2206 an agent with the potential for teratogenic or abortifacient effects; because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother with MK-2206, breastfeeding should be discontinued if the mother is treated with MK-2206; these potential risks may also apply to other agents used in this study
- Patients with unstable angina, congestive heart failure, or with a history of a myocardial infarction within 6 months; patients with high-risk uncontrolled arrhythmias (ventricular tachycardia, high-grade atrioventricular [AV] block, supraventricular arrhythmias which are not adequately rate-controlled); patients with uncontrolled hypertension (i.e., over 160/90 mmHg); patients who are controlled on anti-hypertensive medication will be allowed to enter the study
- Patients known to be human immunodeficiency virus (HIV)-positive and are on combination antiretroviral therapy are ineligible because of the potential for pharmacokinetic interactions with MK-2206; in addition, these patients are at increased risk of lethal infections when treated with marrow-suppressive therapy and as such patients with cluster of differentiation (CD)4 counts < 200 will be excluded; HIV-positive patients not on anti-retrovirals and with an adequate CD4 count will be considered eligible
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01705340
|United States, New York
|Memorial Sloan-Kettering Cancer Center
|New York, New York, United States, 10065
|Principal Investigator:
|Devika Gajria
|Memorial Sloan Kettering Cancer Center
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|Other Study ID Numbers:
NCI-2012-01759 ( Registry Identifier: CTRP (Clinical Trial Reporting Program) )
MSKCC IRB# 12-129 ( Other Identifier: Memorial Sloan-Kettering Cancer Center )
9102 ( Other Identifier: CTEP )
U01CA069856 ( U.S. NIH Grant/Contract )
P30CA008748 ( U.S. NIH Grant/Contract )
|First Posted:
|October 12, 2012 Key Record Dates
|Last Update Posted:
|September 30, 2013
|Last Verified:
|September 2013
Breast Neoplasms
Stomach Neoplasms
Esophageal Neoplasms
Breast Neoplasms, Male
Neoplasms by Site
Breast Diseases
Skin Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Gastrointestinal Neoplasms
Digestive System Neoplasms
Digestive System Diseases
Gastrointestinal Diseases
Stomach Diseases
Head and Neck Neoplasms
Esophageal Diseases
Antineoplastic Agents, Immunological
Antineoplastic Agents
Protein Kinase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action


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Showing 1–12 of 52 results
Showing 1–12 of 52 results
Dear Customer,
We are presently working on Inventory system software to integrate inventory with our website, our goal is to be completed by April 2020. Until that time please be advised, our inventory on the website will show inaccurately, and we will ship the items which are available at our warehouse. Please pardon us for this inconvenience until we are ready.
Also, as you may already know the present unfortunate situation in China with the Corona virus breakout, this also effecting with our supply chain shipments. Which also may delay or create shortage in some of our products.
Most of all our prayer goes out for well-being of All Human kind.
With Regards,
Oceanic Linkways Team.

subset: commoncrawl


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MOOCs: Tearing Down the Ivory Tower
Sep 10, 2013 5:00 AM PT
Massive Open Online Courses, or MOOCs, are served up by a variety of companies, organizations and educational institutions, including Coursera, Udemy, Iversity, EdX and many others. Together, they're garnering millions of students from around the world.
People involved in the MOOC business tend to be passionate about what their work means for students and for education.
Anyone who wants an education should be able to get it, Andrew Ng, cofounder and coCEO of Coursera, told TechNewsWorld.
"Online education in general, and MOOCs in particular, hold great potential for higher education," Hannes Klöpper, managing director of Iversity, told TechNewsWorld. "We strive to unleash this transformative potential."
MOOCs in Context
MOOCs are an outgrowth of online education that has been offered in various forms by most educational institutions for more than a decade. The difference with MOOCs, however, is a matter of scale. Instead of 30 students taking an online course through a university, millions of students around the world can log in, participate, and in some cases even earn college credit for the course.
"MOOCs are a node in the trajectory of online and open educational resources and as such are not themselves changing the nature of higher education," Michael Nanfito, executive director of the National Institute for Technology in Liberal Education, told TechNewsWorld.
"It is critical to contextualize consideration of MOOCs in the environment in which they have emerged and are evolving. MOOCs -- in all their emerging iterations -- will contribute to a pre-existing trend to integrate online technologies into the fabric of higher education."
In With the New, but Not Out With the Old
Despite their wide accessibility and increasing popularity, MOOCs are not likely to replace traditional classrooms any time soon. Rather, they simply serve different populations and different educational goals.
"MOOCs and traditional classrooms are different," said Ng. "One advantage of MOOCs is their convenience. Eighty percent of students already have a bachelor's degree."
MOOCs work particularly well for adult students, who might not be able to quit their jobs and head back to school to learn new skills.
"If you're a working professional and want to learn something new, it's a challenge to go to a class on Tuesdays and Thursdays," said Ng. "MOOCs give more access to education. You have much more control over your learning."
It's not an either/or proposition, though. MOOCs and traditional education can co-exist and even complement each other. MOOCs and other online formats can provide a broad overview of or introduction to a subject, while classroom discussion offers the opportunity to debate, critique and analyze ideas.
"Most of the basics in introductory courses that are usually taught by overworked and underpaid adjunct faculty in big lecture halls can be taught much more effectively in a MOOC format," said Klöpper.
"The time in class should then be used to contextualize the theories that the students have learned about," he said. "When faculty and students come face-to-face, they should use their time to discuss the epistemological questions -- the questions where there are no easy answers."
A World of Possibilities
Some instructors enjoy, in particular, the freedom MOOCs offer to try new course formats and reach a broad array of students.
"I love being able to bring a world-class educational experience to my students at an affordable price," Chris Bryant, who teaches computer certification courses through Udemy, told TechNewsWorld.
"For me, there's no travel, no hotel, no cramped meeting rooms to teach in. It also gives me more time to develop additional courses. I have three new courses debuting on Udemy within the next six months. I couldn't do that if I were always traveling to training sites."
MOOCs are evolving, and it remains to be seen how useful they will be for degree-seeking students and the educational institutions that serve them. For the time being, MOOC providers are expanding their offerings and singing the praises of the one thing no one can deny about MOOCs: They provide easy access to high-level learning to a greater number of people around the world than ever before.
"Many of the MOOCs are breaking down the barriers of affordability and access to higher education by unlocking some of the great educational content and teaching from top global academic institutions," Dennis Yang, president and COO of Udemy, told TechNewsWorld. "By providing free access to this quality content, students around the world can learn from some of the best faculty members in a personalized fashion."


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Basebrawl: The Connection Between Pro Wrestling and the Yankees
As far back as I can remember I have always loved the New York Yankees. But in the fall of 1996, a new form of sports (or sports entertainment, I should say) piqued my interest.
November 17, 1996 is when I watched my first World Wrestling Federation Pay Per View, a match called "Survivor Series." The event took place at the world's most famous arena, Madison Square Garden in New York City, some eight or nine miles away from Yankee Stadium.
MSG is a venue the WWE frequents and if you talk to any wrestling fan, they will agree that The Garden is to the WWE what Yankee Stadium is to the Bronx Bombers.
As a 9 year-old it was a crazy experience. I watched in awe as wrestlers like The Undertaker, Mankind, Bret Hart, The British Bulldog, Rocky Maivia (who later became The Rock and is now in the movies known by his real name Dwayne Johnson) and Shawn Michaels battled it out in the squared circle for glory, honor, and respect.
Ever since then, I have found wrestling and Yankee baseball to be two of my greatest interests; two sports that have kept me involved for a long period of time. In recent times, it's been easy to make connections to the world of pro-wrestling and the Yankees.
Some Yankee players have openly admitted that not only do they watch wrestling, but they are fans of the WWE. In the WWE, the wrestlers have oftentimes referenced the Yankees–in both good ways and bad–in order to generate a reaction from the live audiences.
What some people do not understand is that pro wrestling, although considered by me and many others to be a real sport, is what is commonly known as "sports entertainment." While there is a sheer amount of athleticism that goes on in each and every match, the storylines and a large majority of what happens on the TV shows (a la Monday Night Raw and Friday Night Smackdown) is scripted.
In laymen's terms, it's a soap opera with body slams. Yet wrestlers still get injured during matches and they put their bodies on the line to satisfy the crowds, which is why, to me, pro wrestling is in fact a real sport. People can say whatever they want to about wrestling being "fake" but as Bret "The Hitman" Hart once said,
"Wrestling is far more real than people think."
As it relates to the Yankees, there have been a few moments that stand out to me which connected the WWE and the Yankees. One instance was January 28, 2008. WWE was at The Garden for their annual Royal Rumble Pay Per View.
Santino Marella, a comedic character who is known more for his outlandish demeanor rather than his in-ring ability, came out to address the New York crowd. Being a heel, wrestling's terms for a bad-guy (or a wrestler disliked by the crowd), Marella proceeded to put down my favorite team.
"The Yankees," he said. "Chokers! Help, it's a mosquito! I am going to blow the playoffs!"
Of course he was making reference to the infamous 2007 postseason- Joba Chamberlain "Bug Game." Watching the PPV at a friend's house, Marella's remarks got me really angry; especially since the Boston Red Sox went on to win the World Series that year. I even remember rising up out of my seat and walking towards the TV set because he had hit a raw nerve of mine, as if I could do anything about it.
Over a year later, Marella (upon becoming a baby face, or a wrestling good guy) wore a Yankee jersey when the WWE returned to MSG for a show.
And that's the beauty of wrestling sometimes–that it commands emotion. A wrestler can say things that just want to make you reach through the television set and strangle them, but at the same time, you love what they are doing.
Another great Yankee-WWE moment was back in either late 1999 or early 2000. Two wrestlers known as Edge and Christian (who like Marella were also heels) were the tag team champions. The WWE was in Atlanta for their Monday night television program, Raw.
The tag champs went out to the ring and did what they liked to call their "Five Second Pose," A.K.A. they stood in the ring, told everyone in the audience to get their cameras out for a photo-op, and they mocked the sports teams of whatever city they were in at the time. The Braves were coming off their 1999 World Series loss to the Yankees and had also been beaten by the Yanks in the 1996 fall classic.
Edge said to the capacity crowd, "The Atlanta Braves are known for one thing–being the New York Yankees' personal b*****s."
Christian then put on a Braves jersey, while Edge sported the Yankee pinstripes. Christian got down on the canvas of the ring, hugging Edge's ankles while Edge stood proudly with an evil smile on his face and gave a thumbs-up.
The Atlanta faithful responded with a boisterous chorus of boos.
As a Yankee fan, yes, it was hilarious and unbelievably entertaining. But I know that every Braves fan in attendance that night was furious; I believe they all felt the same way I did when Marella put down the Yankees, and more likely than not wanted Edge and Christian's blood.
Again, wrestlers have the ability to command emotion. They can make you feel happy or so mad you want to beat them up.
Although the WWE wrestlers are known for making references to the Yankees, it works both ways. Numerous Yankees these past few years have admitted their admiration of wrestling.
Johnny Damon, a Yankee of four years, guest hosted Monday Night Raw in December following the Yankees' 2009 World Series Championship. Damon, although an excellent baseball player, was not the best host for the show. I noticed throughout Damon's tenure with the Yankees that he stuttered a lot during his postgame interviews; he never really gave the best sound bites for the media.
His stuttering, and in a lot of ways bad acting skills, did not come off looking any good on Monday Night Raw. I can remember saying one thing to myself after the show ended that night:
"Stick to baseball, Johnny. Stick to baseball."
Wrestling has evolved over the years and has gone through a number of huge changes. These days the WWE's most popular superstar is a man by the name of John Cena, who has been in movies, has guest starred on TV shows, and has done a lot of charity work for the Make-A-Wish Foundation. Basically Cena is the WWE's top man and its hottest commodity.
In February of 2009, Cena joined Derek Jeter, Tiger Woods (obviously before the controversy), Reggie Bush of the New Orleans Saints, and Denny Hamlin of NASCAR to help launch a new razor–the Gillette Fusion Gamer.
WWE interviewed Jeter and he said he told Cena that he needs to find the time and get out to a WWE show. It was funny to me, simply because I cannot picture in my mind Jeter, the classy captain of the New York Yankees, sitting ringside in an arena alongside a bunch of howling wrestling fanatics.
However, I would love to see it happen. As a person who has attended countless WWE live events, it is quite an experience. I highly recommend going to a WWE show, so I do hope Jeter can eventually "get out to one."I guarantee he will have fun.
In 2009, the Yankees brought the spirit of WWE to their clubhouse. Pitcher A.J. Burnett's son gave Damon a replica WWE Championship title belt to keep in his locker. From there on out, the Yankees awarded the belt to whoever was the hero of the game.
For example, Damon hit a walk-off home run on May 17, 2009 vs. the Minnesota Twins. After the game, the team declared him the champion and he got to hold the belt until the next hero was named.
WWE caught wind of this, and as it turned out, they rewarded the Yankees for it. CC Sabathia is good friends with WWE Hall of Famer, Jerry "The King" Lawler, stemming back to his days as a member of the Cleveland Indians–Lawler's number one favorite team.
According to reports in June 2009, Lawler sent Sabathia an upgraded version of the WWE title. The report also mentioned that instead of the WWE logo, the belt featured the interlocking NY to fit the Yankees.
From what I read, the Yankees eventually signed their original WWE belt and auctioned it off, with the proceeds going to charity. Knowing the WWE and the amount of charity work they undertake on a yearly basis, they were probably very happy with the actions of the Yankees regarding the belt.
To me, wrestling will always be a wonderful art form. Good guys, bad guys, drama, athleticism, high-risk action, exhilaration, and laying it all on the line–the WWE has everything.
Other than football, I can't think of any other sport that interests me more in the baseball off-season than wrestling. And when the WWE and the Yankees collide, as they have in the past, it is the best feeling in the world for me; it is two of the greatest sports in the world coming together.
And it is my hope that the Yankees and the WWE maintain a great relationship in the future. Perhaps Wrestlemania, WWE's version of the World Series, could be held at Yankee Stadium.
Talk about a dream come true.


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Limulus necesitaba un nuevo diseño de página web y lanzó un concurso de diseño en 99designs.
Un ganador ha sido elegido entre 38 diseños de 8 diseñadores freelance.
Me: I provide my clients with sites to market their products or services in the best light possible.
As a former designer, I have both great respect for design work, and an understanding of the process involved. I strive to provide all with as much feedback as I can. I'm also always looking for designers with whom I can establish longer-term working relationships. Even if this contest isn't for you, but your interested in keeping in touch, just send me a message.
My Client: A business that renovates and restores homes that have suffered damage from any number of accidents or catastrophes.
The target audience is the home owner that is need of emergency restoration services. In the majority of cases, this is a stay-at-home mom, but could be anyone in the household. In all cases, it will be someone that is looking for professional service from a company that will take care of them, and that they can trust.
The target audience has usually recently undergone the trauma of having a lot of damage happen to their home, and they are looking for a company that they can trust. We want them to feel that they will be extremely well treated and have nothing to worry about. The team will restore their home to its original condition, or better. We want people to feel like everything is going to be ok.
The site won't be too complex - a single front page design is what is needed most. It will need to accommodate a large flash banner on the front page that will introduce the business
We're looking for something that appeals primarily to mothers or other home owners that have recently experienced damage to their homes and are looking for a company that will take care of them and make their home a great place to live again.
The site will feature some education on some common problems, and will showcase some before and after shots of other renovation jobs
Some words to describe the feel of the site:
- warm
- clean
- safe
- lively
- friendly
- family
- professional
- peace of mind
The site needs to be better than sites from similar services, such as the following:
I've attached a wireframe PDF that indicates some of the content and the general layout. You don't have to follow the layout exactly - please be creative. Two low-quality logos are included - it needs to be present on the site somewhere visible. The second one (default_01.jpg) seems to be the closest to the corporate colours - try to keep it close, but there is a little bit of room here to work with the blue.


text:
Kuno Becker doesn't have any movies playing in theaters.
If you feel like heading out, check out other movies in theaters.
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Movies.com, the ultimate source for everything movies, is your destination for new movie trailers, reviews, photos, times, tickets + more! Stay in the know with the latest movie news and cast interviews at Movies.com.
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Due to the Coronavirus Epidemic being felt worldwide, our inventory levels are being pressured for hand sanitizer, N95 and half-mask respirators, and some other goods. At this time, we are currently Sold Out of all half-mask respirators, disposable masks, and hand sanitizer. Product is still available for order, however product may take up to a month to be received. We will be reviewing and shipping inventory in order to satisfy our customers to the best of our ability based on historical purchases and current stock levels.
Lead time displayed for items not in stock will be longer than predicted. We thank you for your understanding.
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SCOTTSDALE, Ariz. (CBSNewYork/AP) — They'll play in the Far East and the Far West — and in the Caribbean, too. Wherever they are, Miguel Cabrera and R.A. Dickey and dozens of All-Stars in the World Baseball Classic know the team to beat: two-time WBC winner Japan.
The Japanese are hoping to defend their title in the third edition of baseball's global tournament, having topped Cuba in the inaugural Classic in 2006 and South Korea three years later.
To do it, Japan — with a roster that doesn't include a single player from Major League Baseball — will have to win two rounds at home and then the semifinals and final at San Francisco's AT&T Park.
In their way will be an American team led by Dickey, Ryan Braun and Joe Mauer, trying to make up for a couple of underwhelming WBC showings — and featuring Joe Torre's return to the top step of the dugout.
David Wright of the Mets and Mark Teixeira of the Yankees will also represent the United States.
Team USA has plenty of motivation. The Americans didn't get out of the second round in 2006, then lost in the semifinals to Japan three years later.
"We'll probably be disappointed if we don't make it to San Francisco," said Giants right-hander Ryan Vogelsong, slated to be the No. 2 starter in the U.S. rotation. "First and foremost, we're focused on getting there."
Japan's pro teams are known for their rigorous spring training regimen, which typically begins a couple of weeks before the major league clubs and feature all-day workouts with just a short break to eat.
"It's such a dedicated group of players. I go back to going over to Japan as a member of the Mets back in 74 and just noticing and at that time I didn't think necessarily that the Japanese could play at our level, maybe stature-wise," Torre said. "Even though their game was clean and disciplined, it just didn't look like they were as good as we were. That's certainly has changed."
Rockies slugger Carlos Gonzalez will play alongside San Francisco's Pablo Sandoval and Triple Crown winner Cabrera for Venezuela. The World Series champion Giants have had to plan carefully this spring to get through the Cactus League with much of their roster headed to the WBC — Marco Scutaro on Venezuela, Angel Pagan on Puerto Rico, Vogelsong and reliever Jeremy Affeldt on the U.S. team, closer Sergio Romo pitching for Mexico.
"It's my first time representing and I'm really looking forward to doing it," Pagan said. "The first two Classics I couldn't do it because I was either trying to make a team or I was trying to be the everyday player. It fills my heart to go out there and play in front of my countrymen and in front of my family. I did it when I played in New York and Puerto Rico but it's not the same when you're wearing the P.R. jersey."
And CarGo sure is confident in Venezuela's chances.
"I don't think we need practice — Venezuela doesn't need practice," he said. "Japan, they train together for a long time and get prepared for that. We don't really get prepared for that … put the uniform on, let's play."
In all, 45 big league all-stars, including seven MVPs, were on the final WBC rosters.
Many MLB players are torn between playing for their country or playing for the club that signs their paycheck — especially those who might be on the bubble of making a major league roster or earning a starting job.
Gonzalez said the Venezuelans feel tremendous pressure to take part in the Classic, yet he understands why Seattle ace Felix Hernandez has passed after signing a $175 million, seven-year contract earlier this month that made him the highest-paid pitcher in baseball.
"You have to represent your team," Gonzalez said. "You see all the news about King Felix not playing for Venezuela and the whole country changes, they get upset that you're not going to play for your country. They think it's all about the money but, you know what, we've been working since we were 16 years old and we came from Venezuela to represent. … I think I made the right choice."
The inaugural 2006 Classic featured a pool-play format, while 2009 was double-elimination — and this one will be a combination of both. The first round will be pool play, with the top two teams advancing. The second round is double-elimination, and the top two teams from each group will reach the semifinals.
The Americans will play their round-robin games at the Arizona Diamondbacks' Chase Field in Phoenix. The other first-round groups will play in: Fukuoka, Japan; Taichung, Taiwan; and, San Juan, Puerto Rico.
"The guys who have played this before were excited to get back to it," Torre said. "I think it's still something to get a little used to. Let's admit it, you play the USA team, MLB, even though there are a number of MLB players obviously playing for other countries, it's like putting on your Sunday best, you know. We're excited because we have a chance to beat them at their own game, so to speak."
Semifinals will be played March 17-18, with the championship March 19 in the Giants' waterfront ballpark.
That's where Sandoval cleared the fences three times in a Game 1 World Series win against the Tigers.
The guy known as Kung Fu Panda hopes to find his groove again for his country. If he does, and his nation wins it all, Sandoval will be World Series, Venezuelan and WBC titles to his credit.
"I'm trying to get the Triple Crown," Sandoval said.
— Animated crowds with a different flavor than the regular MLB fans. Expect musical instruments, patriotic chants, face paint and flags. More than 1.5 million fans have attended games in first two WBC tournaments.
— This year's 16-team field was drawn from the top 12 nations in the last WBC, plus four others who qualified in a tournament last year. The WBC winner will be named "world champion" for the first time.
— Americans on a mission: Team USA failed to reach the championship game of the first two Classics.
— Players will be subject to drug testing by the World Anti-Doping Agency.
— San Juan will host games for the third time at Hiram Bithorn Stadium, to be played March 7-10.
— Sparkling new Salt River Fields at Talking Stick, the shared spring venue of the Arizona Diamondbacks and Colorado Rockies, will be on display for the world to see. The ballpark hosts Pool D games between the U.S., Italy, Mexico and qualifier Canada.
How far do you predict Team USA will go in the WBC? Will you be watching? Sound off with your thoughts and comments below…
(TM and © Copyright 2013 CBS Radio Inc. and its relevant subsidiaries. CBS RADIO and EYE Logo TM and Copyright 2013 CBS Broadcasting Inc. Used under license. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.)


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WTF: Tranny Says Math Hoffa Impregnated Him Rocking A "I Love Math Hoffa" Shirt
Remeber that guy who was talking about it. This got to be some type of stunt.
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EL DORADO — Disregard the Plain Jane introduction to Mystic Creek Golf Course just west of El Dorado.
Along Highway 335, in black letters on a small white sign, the words, GOLF COURSE, mark the proper turn. A pitching wedge down a dirt road, the paved parking lot begins, slightly uphill to a trailer that doubles as the interim clubhouse.
From that point on, all else surpassed expectations.
Start with the practice area, designed with two tiers so grass is always available. Check out the short-game area and move on to the putting green with pitch and roll that duplicate on-course contours. Golfers of a certain age will embrace the availability of six sets of tees — 7,492 yards from the black and 5,518 from the yellow.
That preamble whet the appetite for the 18 holes. Cut through a myriad of pines, the course is first-class.
Developer and part-owner Pete Parks provided the guided tour, accommodating somebody on a tight schedule. We played a hole here and there, circumventing players who paid to play, and soaking up the scenery. Always on the lookout for a funky hole or two, I found none.
Miss a green and encounter run-offs similar to those at the Donald Ross-designed Pinehurst No. 2, site of the 2014 U.S. Open. First-hand experience with the Ross influence occurred when a 7-iron was a yard too long on the par-five first that turns right and downhill and then back left with water awaiting too much draw. Faced with a bump into a hump to a green that slopes towards the water, I was ecstatic with the leave of 10 feet.
Mystic Creek reflects the work of other famous golf course architects — the tee to green shaping of Alister McKenzie (Augusta National) and the bunkering of W.A. Tillinghast (Winged Foot) — the result of Parks' travels to most of the best-known public access courses in the country and some of the well-known private courses.
A graduate of El Dorado High School and a football player at the University of New Mexico, Parks gave pro football a shot before returning to graduate school in Albuquerque. While there, a co-worker who played collegiate golf, encouraged him to take up the game. A short time later, he returned to El Dorado, recalling the superior courses he played in New Mexico and wondering what it would take to build a quality course in south Arkansas. Along the way, he played a course in Farmington, N.M., and was so impressed that he filed away the architect's name, Ken Dye.
Aware of 2,000 acres owned by a total of four people, he contacted Dye — no connection to famous golf course designer Pete — and they toured the land.
"I asked him to lay out the best course he could with the information available and I would then attempt to acquire the property," Parks said. Eventually, he purchased 510 acres.
Parks and Tim Zimmerebner — the local pro who had become good friends with Parks — laid out the course from Dye's plans. Dye followed up, connecting flagging tape put in place by Parks and Zimmerebner, so the land could be cleared.
"In watching golf and playing golf, to me the two most exciting shots are the tee shot on a short par four where you have a chance to get to or near the green in one and the second shot on a par five where you have a reasonable chance to get to the green," Parks said.
He insisted on both and Dye complied with the 11th and the fifth, 310 and 512 yards respectively from the whites.
All the way around, they did things right, and there is more to come, including a clubhouse and on-course housing.
The number of memberships are limited to provide room for an expected 7,500 rounds per year by non-members.
Harry King is sports columnist for Stephens Media's Arkansas News Bureau.


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Fukushima long ranked most hazardous plant
Japan's Fukushima Daiichi nuclear plant ranked as one of the most dangerous in the world for radiation exposure years before it was destroyed by the meltdowns and explosions that followed the March 11 earthquake.
For five years to 2008, the Fukushima plant was rated the most hazardous nuclear facility in Japan for worker exposure to radiation and one of the five worst nuclear plants in the world on that basis. The next rankings, compiled as a three-year average, are due this year.
Reuters uncovered these rankings, privately tracked by Fukushima's operator Tokyo Electric Power, in a review of documents and presentations made at nuclear safety conferences over the past seven years.
In the United States -- Japan's early model in nuclear power -- Fukushima's lagging safety record would have prompted more intensive inspections by the Nuclear Regulatory Commission. It would have also invited scrutiny from the U.S. Institute of Nuclear Power Operations, an independent nuclear safety organization established by the U.S. power industry after the Three Mile Island accident in 1979, experts say.
But that kind of stepped-up review never happened in Tokyo, where the Nuclear and Industrial Safety Agency remains an adjunct of the trade ministry charged with promoting nuclear power.
As Japan debates its future energy policy after the worst nuclear accident since Chernobyl, a Reuters review of the long-troubled record at Fukushima shows how hard it has been to keep the country's oldest reactors running in the best of times. It also shows how Japan's nuclear establishment sold nuclear power to the public as a relatively cheap energy source in part by putting cost-containment ahead of radiation safety over the past several decades.
"After the Fukushima accident, we need to reconsider the cost of nuclear power," Tatsujiro Suzuki, vice chairman of Japan's Atomic Energy Commission, told Reuters. "It's not enough to meet safety standards. The industry needs to search for the best performance."
In an illustration of the scale of the safety problems at Fukushima, Tokyo Electric had set a 10-year goal that insiders considered ambitious in 2007. The plan was to reduce radiation exposure for workers at Fukushima to bring the facility from near rock-bottom in the industry's global safety rankings to somewhere below-average by 2017, documents show.
"Severer management than before will be required," Tokyo Electric safety researcher Yasunori Kokubun and four other colleagues said in an English-language 2004 report. That report examined why Japan lagged other countries such as France and the United States in limiting radiation exposure for workers during plant maintenance.
The report came from an earlier period of corporate soul searching by Tokyo Electric, a politically powerful regional monopoly in Japan that ran the Fukushima power station and remains in charge of the clean-up work at the crippled plant expected to take a decade or more.
In 2002, the chairman and president of the utility were forced to step down after regulators concluded the company had routinely filed false reports during safety inspections and hid evidence of trouble at its reactors, including Fukushima. All 17 of Tokyo Electric's reactors were ordered shut down. The last of those did not restart until 2005.
Cost-Saving Culture
As part of a bid to win back public trust, the utility promised to repair a "safety culture" it said had failed in the scandal. Teams of newly empowered radiation safety managers were created and began to audit the company's nuclear operations, including Fukushima. They also reported back findings to other nuclear plant operators and regulators. None of the utility's safety managers who gave those archived presentations responded to requests for comment for this report.
One problem, according to one of those early assessments, was that Tokyo Electric's managers on the ground tended to put cost savings ahead of a commitment to keep driving worker radiation doses "as low as reasonably achievable," the international standard for safety.
Take maintenance, for instance. Japanese plants are required to shut down every 13 months for almost four months at a time -- twice as long as the U.S. average. Tepco was slow to invest in the more expensive radiation safety precautions needed during maintenance, thus lowering the cost of operating Fukushima before the accident.
But that focus on costs also kept Tepco from developing a more active commitment to worker safety that could have helped it navigate the March disaster, officials now say.
After the earthquake, contract workers at Fukushima were sent in without radiation meters or basic gear such as rubber boots. Screening for radiation from dust and vapor inhaled by workers was delayed for weeks until experts said the testing was almost meaningless. At least 39 workers were exposed to more than 100 millisieverts of radiation, five times the maximum allowed in a normal year.
Fukushima Daiichi, built in a poor region on Japan's Pacific Coast to supply power to Tokyo, was pushed into crisis by the massive March 11 earthquake and the tsunami that hit less than an hour later. The backup power systems meant to keep its radioactive fuel cool were disabled, leading to meltdowns, explosions and radiation spewing into the environment, forcing the evacuation of more than 80,000 residents.
Goshi Hosono, the government minister appointed to coordinate Japan's response to the Fukushima crisis, said he was not aware of the details of Fukushima's radiation safety record before March 11 and declined to comment on that basis.
But he said the utility had failed to protect workers in the chaos that followed the accident, prompting a reprimand from government officials and a decision by regulators to take charge of radiation health monitoring at the plant.
"In normal times, radiation monitoring would be left to the plant operator, but these are not normal times," Hosono told Reuters.
Higher Radiation in Old Plants
In a June report to the International Atomic Energy Agency, Japanese officials said basic design failures, a fatal underestimation of tsunami risk and a chaotic decision-making process had contributed to the disaster. But they also said Tokyo Electric's "safety culture" had failed it again.
Outside experts agreed. "The main root causes of this man-made disaster can be found in (Tokyo Electric's) ineffective -- exemplary poor -- safety practices and track record," said Najim Meshkati, an engineering professor at the University of Southern California and former U.S. government science advisor.
In response to questions about the radiation safety record at Fukushima, Tokyo Electric said that radiation exposure for each individual worker at the plant had been kept below the regulatory standard. The overall radiation level remained relatively high because the plant's six reactors were all between 30 and 40 years old at the time of the accident, the utility said.
"Because it was an older plant it required longer maintenance periods and more intensive repair work," Tokyo Electric spokeswoman Ryoko Sakai said. "For that reason, the overall radiation exposure was higher than our other plants."
The General Electric-derived design of the reactors at Fukushima posed a particular safety challenge during routine shutdowns because radioactive steam is allowed to circulate through the power-generating turbine. That means that large parts of the power plant pose a radiation risk during repairs, experts say.
But even compared to other boiling water reactors, Fukushima stood out for its risks. At the start of the decade, each of its reactors had exposed workers to 2.5 times the amount of radiation they would have faced in an average U.S. reactor of the same design. By 2009, that gap had narrowed, but exposure at Fukushima was still 1.7 times the U.S. average and equivalent to subjecting workers on the site to a collective 1,500 full-body CT scans each year.
Because of Fukushima's high radiation, Tokyo Electric brought in thousands of workers each year, often to work just a few days on the most hazardous jobs. The utility employed almost 9,000 contract workers annually on average at the plant over the past decade, according to records kept by Japan's trade ministry.
Those workers were needed in part to allow Tokyo Electric to meet the international safety standard Japan had committed to in 2001. Under that standard, workers were limited to 20 millisieverts of radiation exposure in an average year, equivalent to getting two CT scans at work.
But even with its extraordinary work force, the average contract worker at Fukushima was exposed to 73 percent more radiation than the average nuclear worker at other plants in Japan over the past decade, according to a Reuters review of data from Japan's trade and industry ministry. The same worker was also exposed to almost three times the amount of radiation that Tokyo Electric's own staff faced. The average radiation dose ran almost a third higher than for U.S. workers at similar plants.
The number of Fukushima workers near the annual limit for radiation also remained troublingly high. Over the past five years, each Fukushima reactor exposed almost 300 workers to between 10 and 20 millisieverts of radiation, the Reuters review of the data showed. The comparable figure for U.S. reactors of similar design was just 22 workers per reactor with those kinds of exposure levels.
'This Situation is The Worst'
Part of the reason was that Fukushima maintenance work took almost three times longer than comparable jobs at U.S. plants -- more than four months on average. But American utilities have also spent heavily as a group on steps to reduce worker exposure, including building mock-up reactors so workers could rehearse dangerous jobs almost as commandos would.
"We are ready and willing to spend money to reduce worker doses," said John Bickel, a nuclear safety expert who has consulted for the NRC and the IAEA. "I would characterize that there is an intense competition in the U.S. to be the lowest."
By contrast, critics of the Japanese nuclear industry cite records showing how Tokyo Electric and other utilities shifted the health risks of operating nuclear plants to a group of relatively poor and sometimes homeless day laborers desperate for a quick payday.
"Nuclear power is based on discrimination, a system in which the people who are working to protect nuclear safety end up on the streets and are given the cold shoulder by society. All of us who use electricity are responsible for this system," said Yuko Fujita, a former physics professor at Keio University who has campaigned for nuclear worker safety in Japan for over 20 years.
To be sure, Tokyo Electric had taken steps to reduce the amount of radiation workers faced. It changed the chemistry of water piped through the reactors to reduce corrosion in pipes. It developed robots and remote-controlled probes to inspect hazards rather than sending in workers. And it used radiation shields such as lead "blankets" wrapped around pipes during maintenance to limit radiation in places workers had to be.
Those measures had reduced the overall radiation exposure for workers at Fukushima to a third of the 1978 peak by the start of the past decade, the records show.
But by 2006, Tokyo Electric safety managers had decided that they had to take on a tougher problem to make any more progress. They needed to reform the basic organization of the utility, where maintenance managers faced no pressure to meet targets for reducing radiation exposure for the thousands of contractors and day laborers, two reports show.
The only more dangerous plants from 2003 to 2005 on that basis had been the Tarapur nuclear plant in India, where two reactors shared the basic Fukushima design, and the Perry nuclear plant on Lake Erie outside Cleveland, Ohio.
Perry, which is operated by FirstEnergy Corp, was cited by the Nuclear Regulatory Commission for a series of safety mistakes during a maintenance period in April. In that incident, regulators said four workers were exposed to high levels of radiation after being sent to retrieve a radiation monitor near the reactor's core. The plant has been the target of NRC safety inspections for more than three years because of what U.S. regulators call "human performance" issues in safety management.
Complacency Sets in
Tokyo Electric did not come to terms with its own management and organizational problems related to safety until recent years, the record shows.
Shiro Takahira, a Tokyo Electric manager in charge of radiation safety, showed a conference in October 2006 a chart depicting Fukushima Daiichi as the third-worst nuclear plant in the world in terms of worker exposure to radiation.
"This graph could be a good driving force to improve our process," Takahira told the radiation safety conference in Niigata, Japan, according to remarks posted by the organizer. Takahira said Tokyo Electric had traditionally "put more weight on cost effectiveness" than the need to keep driving radiation exposure down. "There has been no standard mechanism to promote (the standard of 'as low as reasonably achievable') systematically and continuously," he said.
By late 2006, radiation safety managers such as Takahira had won a seat at the table in planning repair jobs at nuclear plants including Fukushima. By 2007, the company set a goal of getting the annual radiation at each Fukushima reactor to about 2.5 sieverts, a more manageable dose equivalent to about 250 CT scans for workers. That would mean Fukushima was still lagging the industry but by a narrower margin.
The full-year radiation for 2008 and 2009 came in just below 2.5 sieverts of exposure per reactor, just under the goal managers had set in 2007. On a three-year rolling basis, the exposure was 2.53 sieverts per reactor between 2007 to 2009.
"We had largely reached our target by 2009," said Tokyo Electric's Sakai.
At that point, some of the urgency behind the safety campaign appeared to drain. "We'll continue to try to reduce occupational exposures by every possible measure after cost performance evaluations," Shunsuke Hori, a Tokyo Electric safety manager, said at a September 2009 conference in Aomori, Japan.
Hori was one of two Tokyo Electric safety managers who published what amounted to a declaration of victory after the nascent effort to improve radiation safety.
"The reliability of Japanese nuclear plants is now quite high," Hori and another Tokyo Electric manager, Akira Suzuki, wrote in a radiation health journal. "The Japanese nuclear industry has over 40 years of radiation protection experience, and it is believed that more radiation control will be possible in the future using this experience."
The upbeat assessment was published in a little-read scientific journal, Radiation Protection Dosimetry, on April 26, 2011, the 25th anniversary of the Chernobyl disaster.
On the ground in Fukushima that day, white smoke was still steaming off three of the reactors, and residents to the northwest had started a wider round of evacuations.
[Source: By Chisa Fujioka and Kevin Krolicki, Reuters, Tokyo, 26Jul11]
Informes sobre DESC
|This document has been published on 27Jul11 by the Equipo Nizkor and Derechos Human Rights. In accordance with Title 17 U.S.C. Section 107, this material is distributed without profit to those who have expressed a prior interest in receiving the included information for research and educational purposes.


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Hello and welcome to this tutorial,
Here I will try to explain one of the ideas behind building an XML driven tree view and how to add some functionalities (firing events / reading attributes), also, how to get rid of some problems we usually face regarding the xml structure and variables scope.
Before you start:
This tutorial requires the following skills:
- Javascript, Intermediate.
- HTML, Intermediate.
- DOM, Intermediate.
- XML, Basics.
- Ajax, Basics.
- CSS, Basics.
Note: if you dont like to go through this and you just want to use it as a snippet, you can download attached files and refer to the Testing step for some instructions.
The Idea:
First thing came in to my mind was to use the unordered list elements because of the way it looks, but after a while I realized that any block-level element can work just fine, so I decided to use nested paragraphs elements with a little help from CSS to add left padding which gives the nested appearance.
The idea Im working on is to fill the tree recursively, its very simple when you know what youre doing and why youre doing it this way.
Anyways, we will read the xml nodes one by one, create/attach necessary HTML elements/ events / styles, after that we check if this elements has children, if so we call the same function again to build the tree based on the current html element and xml node.
So, basically the function must be able to process any node we pass.
We will end up with something like this:
Each parent/item is a paragraph,
Each paragraph contains two spans, one for the icon and the other for the display text.
Paragraphs may be contained in in each other.
Due to the security applied on XMLHttpRequest, Local host / web host is required for testing.
Prepare your favorite text editor,
3 images 16x16 to represents (a parent node closed book, opened parent node opened book, and an item within a parent file)
We will deal with 3 file types (XML as the data source, Javascript the core script, CSS to control the display and the html file for testing).
This code was tested on IE 8 standard mode, FF 3.6.3 and Chrome 5.0.375.17.
All needed files are attached, so no need to bother copying / pasting.
XML file structure:
- It a basic xml file nothing special, only one attribute (text) is needed to be used as the node display text.
- Node names are just used to facilitate the human reading. (Unless you want to use them with something different, this requires a small modification to the code).
- It doesnt matter how much nested youre tree is.
- All text nodes will be ignored.
- White spaces between opening and closing tags considered as text nodes in some browsers, and this will make the script think that this has children tags inside and it will look as a parent element in this case.
Lets start:
Lets first create the main function xmlTree() with its properties as following:
Main properties:
url: (string) the xml file url to be loaded.
parameters: (string, name=value pairs in URI format) parameters that you may want to pass to the xml file generator (in case of using server-side script to generate the xml).
container: (HTML element) the HTML element that will contain the Tree, the default Is the documents body.
Event properties:
onParentClick: (function) function to handle a parent click event.
onItemClick: (function) function to handle an item click event.
onParentDblClick: (function) function to handle a parent double click event.
onItemDblClick: (function) function to handle an item double click event.
Style properties:
parentStyle, itemStyle: (string) CSS class name to be applied to the parents/items paragraph elements
parentIconStyle, parentOpenedIconStyle,itemIconStyle: (string) CSS class name to be applied to the icon span inside each paragraph.
parentSelectedTextStyle, itemSelectedTextStyle: (string) CSS class name to be applied to the selected parent/item text span inside each paragraph.
parentTextStyle, itemTextStyle: (string) CSS class name to be applied to the parent/item text span inside each paragraph.
Reference properties:
selectedNode: (Object contains a reference to the HTML element and a parent indicator as Boolean ) holds the last selected parent/item (for internal/external use).
Xml: (XML object) holds the loaded xml file (you can use it to pass an already exist xml document without calling build() function).
function xmlTree(){ // main properties this.url=null; this.parameters=null; this.container=null; // events handlers this.onParentClick=null; this.onItemClick=null; this.onParentDblClick=null; this.onItemDblClick=null; // style properties this.parentStyle=""; this.itemStyle=""; this.parentIconStyle=""; this.parentOpenedIconStyle=""; this.itemIconStyle=""; this.parentSelectedTextStyle=""; this.itemSelectedTextStyle=""; this.parentTextStyle=""; this.itemTextStyle=""; // reference to the last selected node this.selectedNode=null; // reference to the loaded xml document this.xml=null;
Lets declare the magic property(me).
var me=this;
It looks weird!. Why do we need such thing?
In fact, this variable will be used when (this) statement will refer to something other than the function xmlTree().
Inside an event function, (this) statement will refer to the object that triggers the event, and in such situation we cannot access the xmlTree() properties using it, it just a variable scope issue.
Build() function:
This function uses Ajax to load an external XML file; it will do some validations and error checking,
Im not going to add details about how Ajax works since its not our objective, but all what we want to know is that after successful request, Ajax will supply us an xml object, and we will send this object to refresh() function.
Here is the code; I added few comments where I thought it may be useful.
// send a request to load the xml document and call buildTree() when loaded this.build=function(){ var xmlhttp; // check if Ajax Is supported try{xmlhttp=new ActiveXObject("Msxml2.XMLHTTP")} catch(e){ try{xmlhttp=new ActiveXObject("Microsoft.XMLHTTP")} catch(e){ try{xmlhttp=new XMLHttpRequest()} catch(e){ alert("Your Browser Does Not Support XMLHTTP"); return false; } } } // check if url property is initiated. if (me.url==null){alert("url property must be set");return false;} // check for successful load xmlhttp.onreadystatechange=function(){ // document is ready if (xmlhttp.readyState == 4){ // xml cannot be loaded if(xmlhttp.status!=200){ alert(xmlhttp.status+", "+xmlhttp.statusText); return false; } // xml is loaded, call builTree() function // some browsers don't recognize the xml if read as plain text, so we need to override the mimeType if(xmlhttp.overrideMimeType)xmlhttp.overrideMimeType('text/xml'); me.xml=xmlhttp.responseXML; me.refresh(); return false; } } // add the parameters if exist, and send the request using GET method var furl=me.url+"?"+((me.parameters==null?"":me.parameters+"&")+"rnd="+Math.random()) xmlhttp.open("GET",furl,true) xmlhttp.send(null); }
refresh() function:
Its very useful when we need to update the xml for an already built tree, so it will reset some properties/functions then it passes the buildTree() function two parameters: (me.xml, me.container).
// refresh this.refresh=function(){ // set the default container if not specified if(me.container==null)me.container=document.body; // clear any existing contents me.container.innerHTML=""; // disallow text selection me.container.onselectstart=function(){return false}; me.container.onmousedown=function(){return false}; // reset the last selected node referrer me.selectedNode=null; // start building process me.buildTree(me.xml,me.container); }
buildTree() function:
The previous function passes the xml object and the container element (the documents body if not specified).
Before we can loop all over the XML elements we have to get rid of the automatically generated node (#document) , replace it with the real document element and store it in the (dElem) variable for later use.
After that we get the child nodes of the document element (and later, for passed node)
We exit the functions if the passed xml object is null or no more children found.
// Build the tree recursively var dElem; this.buildTree=function(xmlObj,htmlNode){alert(xmlObj.nodeName) if (xmlObj.nodeName=="#document"){ xmlObj=xmlObj.documentElement; dElem=xmlObj; } if(xmlObj==null)return false; var xmlNodes=xmlObj.childNodes; if (xmlNodes.length==0)return false;
The loop:
I tried to use for-in loop but it always fails on IE browsers, so I used the regular for loop and access the xml nodes by its indexes (xn stands for xml node)
Ignore the auto generated text nodes (#text)
Check if (xn) is a parent node and store the result in (isParent).
for (var i=0 ;i<xmlNodes.length;i++){ var xn=xmlNodes[i]; if (xn.nodeName=="#text")continue; var isParent=xn.hasChildNodes();
Create an HTML paragraph element (pn) to hold the icon and the text spans (and other paragraphs if its a parent node), and attach the corresponding CSS class name to it (if its a parent node or an item).
var pn=document.createElement("p"); pn.className=isParent?me.parentStyle:me.itemStyle
Create two HTML span elements (icon, txt) to hold the parent / item icon and parent / item text, then attach them the corresponding CSS class name.
Read the (text) attribute from the xml node (xn) to be the inner html of the (txt) span.
Append (txt, icon) to (pn)
Hide the html paragraph node (pn) if its not directly nested in the document element (all other nodes will be collapsed)
Append (pn) to the passed argument (htmlNode) (container property for the first time) and store a reference to it in (hn) (hn stands for html node), in case of (hn) is a parent it will be passed to the function again as (htmlNode) argument.
Create a new property for the html element (pn) which is (xAttributes) to hold the (xn) attributes array, so we can access them later through the HTML paragraph element (using the object we pass to events handlers or the selectedNode.hnode property).
for (var i=0 ;i<xmlNodes.length;i++){ var xn=xmlNodes[i]; if (xn.nodeName=="#text")continue; var isParent=xn.hasChildNodes(); var pn=document.createElement("p"); pn.className=isParent?me.parentStyle:me.itemStyle var icon=document.createElement("span"); icon.className=isParent?me.parentIconStyle:me.itemIconStyle var txt=document.createElement("span"); txt.className=isParent?me.parentTextStyle:me.itemTextStyle txt.innerHTML=xn.getAttribute("text"); pn.appendChild(icon); pn.appendChild(txt); pn.style.display=(xn.parentNode==dElem)?"block":"none"; var hn=htmlNode.appendChild(pn); pn.xAttributes=xn.attributes; //use getNamedItem("attribute name").value to access an attribute
Adding events / parent special treatment:
We will handle two types of events (click / double click), also two kinds of problems we will take care of (event bubbling / variable scope).
Because were using nested paragraphs (the same if we used a list element since it contains nested elements), clicking an element may trigger the click event of its parents (Bubbling), simply we can stop this by setting cancelBubble property to true.
We call select() function to change the text span style of the selected node depending on the node type (parent/item).
When we double click a parent node all its direct children must be expanded/ collapsed and the parent icon must be changed to the open / close mode depending on the parent current status.
Thats why I added a new attribute to each parent paragraphs (isOpened) to hold the current parent status (0 closed, 1 opened), Call expandCollapse() function to do the necessary (well discuss it later).
Accessing the main xmlTree() properties/methods (styles, event handlers ) Using (this) statement is not applicable inside an event handler, (this) will refer to the element that triggers the event and not anymore the xmlTree() function itself,
But if you still remember, the (me) property has been declared to refer to (this) in the main function, and since the handlers are built inside the xmlTree()function scope, the (me) property will always refer to the xmlTree() function.
We call the event handler property if specified and pass it the clicked paragraph html element.
Finally, If the element were working on is a parent element, we call buildTree() function again and pass it the current xml node (xn) and the current html node(hn) to be processed, and this is the recursive part of the function.
if (isParent){ pn.setAttribute("isOpened",0); // Parent double click event pn.ondblclick=function(e){ if (!e)e=window.event; e.cancelBubble =true; me.select(this,1) var isOpened=this.getAttribute("isOpened"); me.expandCollapse(this,isOpened==1?0:1) if (me.onParentDblClick!=null)me.onParentDblClick(this) } // Parent click event pn.onclick=function(e){ if (!e)e=window.event; e.cancelBubble =true; me.select(this,1) if (me.onParentClick!=null)me.onParentClick(this) } me.buildTree(xn,hn); }else{ // Item double click event pn.ondblclick=function(e){ if (!e)e=window.event; e.cancelBubble =true; me.select(this,0) if (me.onItemDblClick!=null)me.onItemDblClick(this) } // Item click event pn.onclick=function(e){ if (!e)e=window.event; e.cancelBubble =true; me.select(this,0) if (me.onItemClick!=null)me.onItemClick(this) } } } }
Select() function:
This function needs the selected html node and if its a parent node or not,
Here we use the selectedNode property and again we access it using (me),
We set the selected style for the text span to the corresponding one and we unselect the old select item if exist.
The selectedNode property is an object that has two properties: hnode, isParent to be internally used to unselect an item.
// Select / Unselect node this.select=function(hnode,isParent){ if (me.selectedNode!=null){ if(me.selectedNode.hnode!=hnode){ me.selectedNode.hnode.getElementsByTagName("span")[1].className=me.selectedNode.isParent?me.parentTextStyle:me.itemTextStyle } } hnode.getElementsByTagName("span")[1].className=isParent?me.parentSelectedTextStyle:me.itemSelectedTextStyle me.selectedNode={"hnode":hnode,"isParent":isParent} }
expandCollapse() function:
This function is called when double clicking a parent node or by calling it directly from outer script and it needs the html parent node to work on and the open/close status we want to execute (0 closed, 1 opened).
You may ask; why do we have to pass the open/close status since its already an attribute in the parent node and all what we have to do is to read it and swap its value?
Youre right but I thought using it this way give us the facility to expand/collapse the node we want by calling the expandCollapse() function and without the need to double click the node (maybe it useful when you refresh the page and you want to reopen the last node user selected).
So, here we check first if the passed html node is a parent or not by looking for the (isOpend) attribute (its only available for the parent elements as we specify)
We loop to hide/show all of the parents children except for the first two items (icon and text span elements) and change the style properties accordingly.
// Expand / Collapse a parent node this.expandCollapse=function(pnode,isOpened){ // exit if the passed html node is not a parent node (all parent nodes has the isOpend attribute) if(!pnode.hasAttribute("isOpened"))return false; pnode.setAttribute("isOpened",isOpened); var children=pnode.childNodes; // set the parent corresponding icon class name pnode.getElementsByTagName("span")[0].className=isOpened==1?me.parentOpenedIconStyle:me.parentIconStyle; // Ignore first 2 elements (the icon and text spans) for(var i=2;i<children.length;i++){ if (children[i].nodeName=="#text")continue; children[i].style.display=(isOpened==1?"block":"none"); } } }
We almost done, so, how do you feel?
Im not going to add any details about the xml and css files, its all up to you and its only will affect the way it looks and how its categorized, so lets move on to testing step (finally ).
As I mentioned before we need to do all tests on a local/web host, so move your file there (you can use attached files) and dont forget about the small icons, it gives a nice looking for the tree.
The example I will present assumes that the files on the server are named as: xmlTree.js, webref.xml, styles.css.
Open your text editor and start creating a basic html document.
At the header, link the CSS file (styles.css if you have it as an external file) and the (xmlTee.js)
Add a dive element (dvTree) to be the container for our tree object.
  <link rel="stylesheet" href="styles.css" />

To make sure everything were loaded, we will start using the xmlTree() function when the body load event is fired.
Lets back again to the header part of the html document and lets create the function (load()) that it will called from the body load event to construct our tree.
Inside load() function we simply create an instance of the xmlTree(), add the necessary properties and call build() function.
I added some comments inside.
In the head part of the document
Try it.
If you try to run xmlTree on IE7 or even IE8 but not in the standard mode youll notice that the icons are invisible, and this is can be easily managed by not leaving the icon span empty, so adding any letter to it (space probably) will fix it (but maybe you have to adjust the css a little bit).
If you already have your xml document loaded or you made some changes to the xml on fly ( or even to the one of xmlTree properties) and you want these changes to be reflected on the tree, you can then reassign the new xml to the xmleTree.xml property (or whatever property you want to change) and call the xmlTree.refresh() function.
// trying to change the xml function update(){ var a=t.xml.getElementsByTagName("topic")[0]; a.setAttribute("text","changed") t.refresh(); }
What if for example you want to collapse the selected parent node?
//collapse selected node function collapse(){ t.expandCollapse(t.selectedNode.hnode,0) }
This was a basic xml tree view object; its not targeting any special kind of processing /procedures,
A lot of customizations you may want to add, things to do to get it work with your needs.
Thats all what I have for now,
Thanks for your patient and sorry about the headache .
Check attached xmlTree.zip (6.08K)
Number of downloads: 2411


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Mel Gibson is back in the big-screen business -- and after a seven-year disappearing act, the actor says he's stronger than ever.
Gibson hasn't been seen on-screen since his 2002 flick "Signs," the sci-fi blockbuster that marked brighter days for Gibson, before the actor was arrested for a Malibu DUI in 2006. During the arrest, Gibson let loose an obscene, anti-Semitic tirade on the arresting officer, a move that made Gibson a cultural pariah -- and put the actor on the biz's black list.
But Gibson, 54, said this week that it's time for him to jump back in his leading-man saddle, saying in an interview with the Associated Press that he's ready to put the controversy behind him and move on with his work, starting with his newest flick "Edge of Darkness."
U.S. & World
"It's 30 years ago that I lost my own personal anonymity," Gibson said. "And it's 30 years ago that the public humiliation began," Gibson told the AP.
"Sometimes it reaches a global level. And what doesn't kill you makes you stronger," Gibson said. "And I'm telling you right now, I'm one strong motherf----- because I'm right back at you."
Gibson dismissed the idea that the anti-Semitic "scandal" would haunt him as he made a return to acting.
"What scandal?" he said. "That's mostly newspaper hype, OK? I can get in with the studio, work with them, or work indepenently as I wish. And I'll go on as I always have," he said.
"Edge of Darkness" features Gibson in a familiar role; the actor plays a revenge-seeking detective getting back at his 24-year-old daughter's killers. Like Gibson's hits "Ransom," "Braveheart," and "Lethal Weapon," "Edge of Darkness" is a blood-drenched, action-filled epic -- a Gibson specialty.
The actor said the film was a perfect fit for his comeback.
"It was time," Gibson said. "I felt like getting back in the saddle."
Gibson continued his bid at a good-guy rep this week as he answered phones for the "Hope for Haiti" telethon, raising cash for victims of the Haiti quake. He also made an appearance at the Golden Globes, joking with host Ricky Gervais about his alcohol issues.
"Edge of Darkness" is only the first of Gibson's upcoming projects: the "What Women Want" actor will also be featured in the comedy flick "The Beaver" and the prison drama "How I Spent My Summer Vacation," which he wrote.
Gibson, who directed the controversial "The Passion of the Christ" in 2004 and the Mayan epic "Apocalypto" in 2006, will also soon direct Leonardo DiCaprio in what Gibson called a Viking epic.


text:
Sitthixay Ditthavong / AP
Members of the Chicago Teachers Union hold an informational picket outside Willa Cather Elementary School on Monday in an effort to call attention to ongoing contract talks with the city's Board of Education.
The Chicago Teacher's Union voted unanimously Thursday to strike on Sept. 10, with members agreeing to head to the picket lines unless a deal can be reached with the city's schools -- a move that could affect 400,000 students.
The result of the ballot, cast at a Chinatown union hall, was met by cheers from the more than 700 delegates who voted.
The decision comes a day after CTU president Karen Lewis issued a 10-day strike notice. Sept. 10 is the earliest that teachers can strike, and the date falls a week after many students head back to class.
"We're tired of being bullied, belittled and betrayed," Lewis said at a news conference following the meeting. "We have done everything asked of us, yet we continue to be vilified and treated with disrespect."
Read the full story at NBCChicago.com
Lewis said negotiations will continue until a contract is hammered out that resolves concerns over wages, job security and a new evaluation system.
In a statement, Chicago Public Schools chief executive Jean-Claude Brizard said: "If our priority is our kids, then strike should never be an option."
"Should CTU leaders decide to strike on September 10, more than 350,000 students will be taken out of their classroom, just as they're making progress with a Full School Day. Varsity sports for 11,000 student athletes will be suspended. More than 400,000 daily breakfasts and meals will no longer be served.
6 July: Students who suffer from drug and alcohol addiction are finding help at special schools where the kids work toward common goals: education, graduation and recovery. NBC's Kate Snow reports.
"College transcripts and recommendations for 20,000 seniors will be put on hold. If our priority is our kids, then strike should never be an option. That's why we need to take advantage of each of the next 11 days and work until we reach a fair resolution for our teachers that will allow our kids to stay in school where they belong."
CPS officials have been making preparations in the event of a strike.
Brizard said the district plans to keep 145 schools open for half-days even if the Chicago Teachers Union calls a strike and teachers walk off the job. The union on Wednesday filed a 10-day strike notice that would allow them to strike as early as Sept. 10, just a week into the school year for a majority of public-school students.
If that happens Brizard said CPS will partner with City Sister Agencies, local faith organizations and other non-profits to keep kids engaged.
"We need to be prepared to provide our students with services they need should CTU leaders decide to strike, and our Children First plan will do that," Brizard said.
As part of the precautionary strategy announced Thursday, CPS would keep the group of schools open from 8:30 a.m. to 12:30 p.m. Monday through Friday to provide activities to children and keep them engaged in independent reading, arts, sports and computer-based programming.
27 June: The City of Stockton, California, is likely to become the largest municipality to declare bankruptcy in an effort to deal with a $26 million deficit and $700 million in debt. Cnbc's Jane Wells reports other cities may soon follow suit.
Per the plan, the schools would be staffed with Central Office personnel, non-CTU employees and organizations that submit a request for proposals to provide programming. Brizard said the staff-to-student ratio would be capped at 1 to 25.
CPS also said it will provide breakfast and lunch to all students at the locations and will extend between 70 and 80 Chicago Park District summer camps.
Brizard said he's committed to avoid a strike but says CPS will be ready if the teachers strike.
"These plans are simply a precaution," Brizard said, "but we have an obligation and responsibility to our children and their parents to make sure they are not left behind in the event of a strike."
CPS said it is seeking a waiver from the Illinois High School Association to continue sports if teachers strike.
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text:
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text:
Mando soldier
New Hunter
So I have been scouring the Jodo Kast threads, and to the gentlemen who completed those costumes they are fantastic, so I am reaching out for your help. What is the recommended color scheme for all of the parts? Are the greens going to be the same as Boba's armor? And for the soft parts, I know the leather pouches are gray and the girth belt brown, but my biggest question is the fight suit and vest. Did you use the same color as Boba', or did you go with a darker gray? And the Boba vest uses that material with a "sheen" to it, did you use the same type of material.So if anyone has a Jodo Kast suit, shoot me some display pictures so I can see how this is done!


text:
Featured News - Current News - Archived News - News Categories
by Joshua Maloni
My brother and I don't share the same tastes.
He's a purple shirt and green Converse-clad Dave Matthews follower. Me, I'm a black and white and Nike-d fan of U2 and alt-rock. We don't agree about music, fashion, sports, politics or which "Godfather" movie is best (by the way, Matt, it's the first one).
But there's one thing my brother and I always agree on, and that's the taste of a breakfast bagel sandwich at Tommy George's The Villa Coffee House. The Village of Lewiston's oldest restaurant, circa 1974, offers pure culinary gold wrapped in see-through parchment paper.
Whether it's bacon, egg and cheese or sausage, egg and cheese ($4.05 each), the sandwich is a great start to any morning - and common ground for the Maloni boys. The hearty toasted bagel bookends a generous amount of meat, savory fried eggs and melted American cheese. It's best served with a side of golden home fries: chunks of potatoes fried and salted to our satisfaction ($1.25 half order or $1.95 full order).
Tommy George's is a popular place early in the morning. The owner's love of golf (as evidenced by photos and knick-knacks throughout the diner) limits his restaurant's hours of operation. The menu reads, "Breakfast served all day - cheerfully," which, in this case, is until 2 p.m.
Many patrons come to the Villa for its famous mixed eggs (an egg and potato base begins at $3.45 for a half order or $3.95 for a full plate). More than a dozen "fixin's" are available, including your traditional breakfast meats (bacon, sausage, ham), two different types of cheeses (American and mozzarella) and more off-the-beaten-path items, such as hot dogs, ground beef and tomatoes (each ingredient is 50 cents).
The mixed eggs remind me of a cross between eighth-grade science and the Food Network's "Chopped." The mixin' doesn't always make sense; it has lots of colors and textures; but, when properly prepared, it's worthy of a blue ribbon. When served with Italian toast (topped, naturally, with mixed fruit jelly), it's a four-star breakfast.
Now, a third Maloni recently entered the Villa discussion, and thankfully so.
I reached out to Mama Maloni for new menu suggestions, as she often eats lunch at Tommy George's. What do I do? How do I combat this early afternoon appetite?
As the mighty Thor called out to Odin and was rewarded with the Mjolnir, a legendary war hammer, so I dialed up my mother and reaped a legendarily good bacon cheeseburger worthy of the god of thunder. Fresh ground beef, hand-shaped into a delicious, juicy patty and topped with crispy bacon, quickly pounded my hunger into submission.
To my burger order ($4.75), I added a side of hot and crisp fries (95 cents for a half order or $1.50 for a full size), and a cup of chili ($2.25, but less when paired as "soup and sandwich" special).
The chili was unlike anything I'd had before. It was as if chili and minestrone had some sort of soup coupling. It was filled with beans (green and brown), onions and celery, and accented with bits of meat and spices. The sauce was light, but full-flavored, and made a great dipping sauce for the burger.
The Villa might not be the newest or flashiest diner in the village, but, for five decades, Tom George has proven he's capable of making breakfast the most important meal of the day. And, if his lunch items are as well made as his burger, than it's about time we all start spending our work break with Lewiston's most famous golf enthusiast.
Tommy George's The Villa Coffee House is located at 769 Cayuga St., next to Tin Pan Alley in the mini-plaza.