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Stainless Steel 3 Quart Saucepan with Cover
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Experience the best corn-on-the-cob you've ever tasted! With Vapor® Cooking, corn-on-the-cob is naturally juicy and sweet. No butter or salt necessary! The 3-quart stainless steel saucepan can also be used to prepare your favorite pasta sauces, rice – you can even boil eggs without water! Diameter 7 3/4
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Brian Robert Omolo AKA Khaligraph Jones took to Instagram to defend and advice new internet sensation Mihadarati Hitmaker -Stevo simple boy.
View this post on Instagram
The OG criticized celebrities and TV personalities who want to use Stevo for clout.
He also criticized interviewers who call Stivo for interviews and start asking him embarrassing questions a instead of asking constructive questions that would help Stivo Simple Boy Career.
View this post on Instagram
"Naona Sai Kila mtu anataka Kuleta Uyu Kijana Interview kwa Show zao sababu Atawaongezea Ratings, alafu Badala ya kuongelea Mihadarati mnaanza kumuuliza kama Yeye ndio the most handsome man when he clearly stated he is not a comedian but an artist,
View this post on Instagram
Sisi wote ni watoto wa Mungu na tusikufe moyo kwa changamoto tunapitia leo. Asanteni na tusisahau, Vijana Tuache Mihadarati… Vitu vipya zinakuja anytime… @tuko.co.ke @madeinkiberaprods @kiberacreativearts #vijanaatuachemihadarati #stivosimpleboy #asanteni #kenya #kibera #stopdrugabuse #love #hope #talent #sanaa #thankyousomuch #president
@chipukeezy make sure All his Expenses are being catered for by anyone who wants to host him on their TV/ Radio/Blog shows, hawa watu wanapenda kuitana interview wanakutumia alafu wanawacha msanii mdogo Aende Nyumbani Njaa bila ata fare ikome Tafadhali, support them, The Og shall be Respected"
View this post on Instagram
Check Out some of the reactions from Kenyans:
bienaimesol "OG ATABAKI KUA JUU. OG ATABAKI KILELENI"
fenamenal "(Add some volume)"
govoi 'That's so true, even the content discussed is never serious to build or challenge an artist, people go ahead to even comment on how the interviewers should be respected, work on their content, the most disgusting is finding out that your host/ess doesn't even know your name on air.
I hate this type of fakers who have lost their touch and now are just waving in fame without any tangible ways to help the industry grow.'
0 comments


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Range of illumination Not all security lights need to illuminate an entire yard.
Some flood lights can use either LED or incandescent bulbs, but if its able to use LED, we recommend going that direction.
Keep in mind, the more watts a bulb uses, the higher your energy bill will.I decided to dig in and find out what all the lighting jargon means and from there shed some light on different types of security lighting.The best security light changes depending on where you plan to install.After reading this study, Ive been looking for a decent flood light to light up my back plante et jardin code reduction patio and keep potential burglars from sneaking around my back porch.One knock on LED lighting, however, is that it emits a colder, blue-hued light.A flood light is any light with a powerful widespread beam, typically used to illuminate large areas, like a yard or playing field.We like solar flood lights because theyre even more energy efficient than LED.From flood lights and motion sensors to solar, LED, and incandescent lights, I didnt know the differences between each product.But are incandescent bulbs really cheaper?Click here to learn more about the different types of security lighting.Any light is better than no light at all, but there are a few important factors to consider when youre shopping around for security lighting.The range of a security light refers to two separate functions for your security light.If youre like me, youll stand in Wal-Mart or Home Depot and look at prices thinking Why should I spend 8 on an LED when I can get an incandescent bulb for a dollar?And thats assuming LED lights dont become more affordable.Incandescent, for years, light bulb technology hadnt moved much beyond the genius of Thomas Edisona light bulb was a light bulb.More lumens equal concours ensm 2017 more light.Here are three energy-efficient LED flood lights that we recommend: Best security lights: comment gagner des gems solar flood lights.Youll change an incandescent bulb 20 times before youll need to replace an LED bulb.What really makes LEDs stand out is their lifespan.
Turns out theyre not.


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This classic crochet baby trapper hat is warm and cozy for baby! It looks cute with large buttons, or crochet your own. Be sure to finish this cute hat with a big poofy pom-pom on top! This post contains affiliate links (for more info, click here) Thanks for your support!
Striped Hipster Slouchy Beanie
{For an updated version, click here.}
When I was pregnant with my son, I decided to learn to crochet, you know, booties, hats and whatnot. Well, relearn, I should say (I took a crochet class for 4-H when I was in 2nd grade, got a blue ribbon on my granny squares).
Thank goodness for youtube! If you want to learn how to do ANYTHING, someone has posted a very helpful video tutorial. The internet is awesome.
My skills are still quite rudimentary, but I really enjoy it and there are some super-cute patterns on Etsy. Not to mention the plethora of FREE patterns out there. Restatement: the internet is awesome.
So, I thought I would throw another free pattern into the mix. It's pretty simply and easy to make: the Striped Hipster Slouchy Beanie!


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Jump to navigation Jump to search
If you want to be a 1337 hax0r, you can also type Underscores using:
The Underscore (also known as Understrike, Low Dash, or Line) is a "special" character only used by fags who rebel against using the SPACE key to separate words from each other. It is represented as a horizontal line the size of the average Asian man's erect penis [ _ ], and typically shares the "Dash" character [ - ] on the same key.
On your Number Key Row, the Underscore key sits between the "0" and "+/=" keys.
Uses for underscores
Underscores have countless uses on the internets. Some of these uses are listed below:
- Loves to hold signatures.
- Forcing yourself to the first position on everyone's friends list.
- ASCII art.
- URLs
- Italicizing text on Skype (Surround the text with underscores, like this: _Niggers_ makes Niggers).
- Also has a shit-ton of uses in programming languages.
Learn To Type
If you want to be a 1337 hax0r, you can also type Underscores using:
Alternatively, just press Shift+-, you lazy bastard.
External links
|Underscore is part of a series on Language & Communication
Languages and Dialects • Grammar, Punctuation, Spelling, Style, and Usage • Rhetorical Strategies • Poetry • The Politics of Language and Communication • Media • Visual Rhetoric
Click topics to expand


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We believe that intellectual capital is critical to providing innovative solutions and, ultimately, having a positive economic impact.
Legal & Compliance — New York
Amy Garges is a Managing Director in the Legal and Compliance Department.Ms. Garges leads the Risks Controls Testing Team for Blackstone. The Risks and Controls Testing program performs a central oversight control function designed to test the effectiveness of Blackstone's compliance control framework across the firm. Previously, she was in the Hedge Fund Solutions Group where she managed internal compliance review matters.Before joining Blackstone in 2008, Ms. Garges worked at PricewaterhouseCoopers LLP as an Audit Manager in the Banking Capital Markets practice where she supervised audit teams, maintained client relationships, and provided accounting advisory services to financial institutional clients. Prior to PricewaterhouseCoopers LLP, she worked at Franklin Templeton Investments as a Tax Audit Supervisor where she managed multiple tax audits and assisted with tax planning projects.Ms. Garges received a BA in Economics from the University of California, Los Angeles. She is a Certified Public Accountant.
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text: 101matt 17 Report post Posted March 19, 2012 (edited) I have been preping to take a walk in the woods and it dawned on me that the small towels I have where white! So I tryed this... Am I taking it to far????lol Edited March 19, 2012 by 101matt Share this post Link to post Share on other sites


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We've been busy loading our booth with all kinds of alpaca goodies and have placed many items on sale. Look what a 10'x20' booth can hold!!! This is taken from the Alpaca Annex store loft looking down on the two aisles in the booth.
Tomorrow, Thursday, we will load it on a trailer. Early Friday it goes to The Dalles where we set it back up again. The market opens at 4 pm: Happy Hour begins with a no-host bar and author book-signings.
To learn more visit the website www.columbiagorgefiberfestival.com.
We're looking forward to a wonderful three days of Festival fun and we hope you can join us.
Remember, it's free!
PS Go to Meadowrock Alpacas' Facebook page to see the entire photo album!


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Agriculture and Forestry University, Nepal
*Corresponding author: Suresh Simkhada, Agriculture and Forestry University, Nepal
Submission: March 19, 2018Published: May 01, 2018
ISSN: 2637-7659 Volume2 Issue2
Diagnostic research on performance of Chickpea (Cicer arietinum) variety under chemical fertilizers use was conducted in IAAS farm of Paklihawa Campus, Nepal to reveal both short term and potential long-term problems in chick pea cultivation in Nepal and evaluate the yield of check pea under chemical fertilizers use. There were three replications of the treatments. The treatments were found significantly different for vegetative as well as yield parameters. The issues for chickpea were found to include pest and diseases, mid-season moisture stress and weed problems. Optimum seedling rate is one of the most important production factors for higher grain yield as well as for quality crop. Indiscriminate use of seed and fertilizer not only increases the production cost but usually decrease yield. The overall performance of check pea was found better under chemical fertilizer application though pest infestation was high.
Keywords: Diagnostic; Check pea; Yield parameters; Production factor; Indiscriminate; Infestation


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Tagged: background, black
I am trying to create a perfectly empty black background for a page, but can't seem to remove the lines at the top and bottom of the content area. Also, the background of the content area is a slight grey. I have set every single background and line parameter to black in the General Styling section of the Theme Options, but still have these issues. Here is the link:
Thank you.
Never mind, I guess the settings were cached, I now have a perfect black background. Wondering though how to prevent settings from caching? It makes it hard to see what you are doing.
To turn off cache, assuming you're not using a third party cache plugin, add the following to header.php in enfold/enfold child theme just after the
<head> tag.
<meta http-equiv="cache-control" content="max-age=0" />
<meta http-equiv="cache-control" content="no-cache" />
<meta http-equiv="expires" content="0" />
<meta http-equiv="expires" content="Tue, 01 Jan 1980 1:00:00 GMT" />
<meta http-equiv="pragma" content="no-cache" />
Hi Arvish,
This is the first time I have added php to my child theme, do I copy the whole header.php file into the child theme folder, or just a blank header.php file, then adding the above code?
Thanks for your help.
Sorry if this is a beginner question, but does the added code go in any particularly location? The beginning? Does it matter?
Thanks, Randall
Thanks Yigit, this is very helpful.
The topic 'Create an empty, black background' is closed to new replies.


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When I first started on FPN, I tried to describe the troubles I was having with my pens clogging. Turns out the inks I was drawn to, were sort of "dry" inks and wet inks worked better in my pens.
So, what exactly is a Dry ink? And what are some examples. I've posted another TOD for Wet Inks.


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The Grizzlies refuse to let Iguodala go for nothing
The storm that formed at the beginning of July in the NBA market has passed, but there is still some way to talk in the future. One of the most obvious is that of Andre Iguodala. The now Grizzlies player arrived in Memphis after six seasons in the Warriors where he was instrumental in the successes of the Californian team. But the acquisition of D'Angello Russell via sing-and-trade forced the franchise of La Bahía to release one of the great contracts of the staff. 222222 Discarded Curry, Klay and Green, they only had Iguodala and his 17 million dollars .
They managed to place their contract in Memphis because they also included a first round. But the Grizzlies, a team in clear reconstruction, does not seem the right place for a player who has proven to be more than useful in the playoffs. So Iguadala is determined that his new franchise will release him from his contract and, as a free agent, he will have the freedom to choose a new destination in which it could be, according to several sources, the last active season of the player who, by the way, he is in the last year of his current contract. 444444
But the Grizzlies do not seem to work . Shams Charania, of The Athletic, has confirmed that in Tennessee they do not consider sitting with the eaves to discuss this possibility and that they would only let him go in a transfer with another team. The goal in Memphis would be to achieve another first round, in addition to some player who would have to enter the lot to balance the 17 million Iguodala charges. Two teams seem to have the pole in these conditions: Los Angeles Clippers and Denver Nuggets. The first have been playing since that July of madness and Moe Harkless, which charges 11.5 million and is in its last year of contract, could be the perfect piece to make the transfer fruitful.
The Nuggets, which have not been talked about so much, are also an aspirant to consider. Marc Stein of The New York Times confirms that they have an "ambitious" plan to try to gain their services. In his case, Mason Plumlee (14 million and also last year of contract) would be the most feasible option. Although according to Stein, they do not seem so convinced to give a first round, something that in their opinion would be too high a price. 444444
Other teams that sound are the Lakers, the Rockets and the Mavericks. 222222 In the case of the first two they have very difficult (if not impossible) to get hold of Iguodala if the Grizzlies don't release him before. The salary space is nil and neither have any player with a similar salary and who can leave (Danny Green in the Lakers or Capela and Gordon in the Rockets) .
Photos from as.com


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** 6th December - Couriers are reporting significant parcel backlogs and some large and heavy item deliveries may now be delayed. Items delivered by Royal Mail are unaffected. Please feel free to contact us to check if your order and post code will be affected before ordering. ** DismissSkip to content
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It's been a long week and as I'm writing this it's only Tuesday. So today I am sharing a super simple Christmas Card made with one of the prettiest sets of Designer Series Paper in the new 2019 Holiday Catalog, Feels Like Frost. See that beautiful scenery? Each paper in the Feels Like Frost Designer… Continue reading It's All About the Paper – Feels Like Frost
Category: 2019 Holiday Catalog
Color Challenge – Ink & An Aquapainter
I recently took part in a color challenge. The challenge was to use three specific colors in a card and to use products that are in Stampin' Up's 2019 Holiday Catalog. It doesn't seem like these colors: Pretty Peacock, Merry Merlot and Pear Pizzazz would be a great combination, but it just so happens that… Continue reading Color Challenge – Ink & An Aquapainter
More Cardinals – Toile Christmas
Good Morning! I'm back again with another cardinal card! You can see the first one HERE. This time it's very monochromatic and easy to make! Here is is: Classic Christmas colors of Red & White (or in this case Very Vanilla) make this card an easy winner in the simple category. The Toile Tidings Designer… Continue reading More Cardinals – Toile Christmas
A Ghoulish Halloween
I'm backing up the holidays....Last week I showed you this Christmas card: Pine Trees & Perfectly Plaid ) and then showed you more of a Thanksgiving card yesterday: A Card(inal) for Many Occasions....so it only makes sense to back up the calendar a bit more and share a Halloween card today. This card is super simple and… Continue reading A Ghoulish Halloween
A Card(inal) for Many Occasions
Don't you just love a play on words? I spent this past week-end crafting for almost 16 hours a day.....at a Home for the Hoiidays Retreat in Northern Virginia with about 20 other crafters. I made 27 cards and 3 fancy box treat holders, all with a holiday theme. Four are Halloween Cards, twenty six… Continue reading A Card(inal) for Many Occasions
Pine Trees & Perfectly Plaid
Had a little delay in getting this posted....so it's now only 96 days until Christmas! Unless you've been perusing Stampin' Up's 2019 Holiday Catalog, you might not know that this post is going to contain a Christmas Card. I know it's early for Christmas....Today marks the 100th day until Christmas! But I needed to make… Continue reading Pine Trees & Perfectly Plaid
The Colors of Fall – Gather Together
Most people think of the palette of fall colors by looking at the trees and the beautiful colors of the leaves that indicates cooler weather is coming.....yellows, oranges, reds, greens. I think of fall colors as the colors in the stadium of my favorite college football team....Virginia Tech Hokies. Chicago Maroon and Burnt Orange are… Continue reading The Colors of Fall – Gather Together
Playing with Leaves – Gathered Leaves
Ever have one of those days when there just aren't enough hours in the day? Or even a week when you have so much to do that you have a hard time just deciding what is most important and what can wait until the craziness that is your life stops swirling out of control? Kind… Continue reading Playing with Leaves – Gathered Leaves
Gather Together
The new 2019 Stampin' Up! Holiday Catalog debuted this week. It's chock full of holiday items for Halloween, Thanksgiving and of course my favorite time of year....Christmas! As a demonstrator, I was able to see (and order) items from the catalog in advance and I've been busy (or at least trying to be busy.....) making… Continue reading Gather Together


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14 Cottage St, Lincoln, RI 02865
Everything must go! BRAND NEW clothing with tags- J Jill, Talbots, Ann Taylor, Chico's. BRAND NEW shoes- Dansko, Coach, Ugg. Tools, air conditioners, and luggage. NEW Holiday Decor. Furniture and...
Sale dates: Saturday, December 7, 2019 - Sunday, December 8, 2019Post date: Monday, December 2, 2019
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1788 Broad Street, Cranston, RI 02905
Many items for sale, old and new, including jewelry, crafts, collectibles, Christmas items, baked goodies, plants, and more. We also have an alternative marketplace where you can make a donation as...
Sale date: Saturday, December 7, 2019Post date: Tuesday, December 3, 2019
71 Oak St, Franklin, MA 02038
Best Rate Cleanouts & Estate Sales is hosting a mind-blowing Military Madness Franklin Estate Sale on Saturday Dec 7th from 9am-2pm. If you are a military collector this is the estate sale for you!...
Sale date: Saturday, December 7, 2019Post date: Monday, November 25, 2019
297 Narrow Ave, Westport, MA 02790
This home is filled with items that the family can not take with them. This leaves some great items ready for the picking. This is a one day only sale and all needs to go,.
Sale date: Friday, December 6, 2019Post date: Friday, November 29, 2019
Spring Hill Dr, Johnston, RI 02919
Come see us for our last sale of 2019 this Saturday in Johnston! This house is filled with nostalgic items, useful tools, kitchenware, and much more. There are hundreds of albums, cassettes, and...
Sale date: Saturday, December 7, 2019Post date: Wednesday, December 4, 2019
153 Ostend St, Johnston, RI 02919
Clothes, household items, furniture etc too much to mention
Sale date: Sunday, December 8, 2019Post date: Sunday, November 24, 2019
941 Hope St, Bristol, RI 02809
Indoor yard sell with home goods, furniture and women's, men's and children's clothing and shoes.
Sale dates: Saturday, December 7, 2019 - Sunday, December 8, 2019Post date: Thursday, December 5, 2019
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text: Get henry copeland's new antidepressants quotes. Subscribe Recent quotes: Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials | Journal of Neurology, Neurosurgery & Psychiatry Thirty RCTs with 1610 participants were included in the quantitative analysis. The overall analysis pooling from 26 of the RCTs suggested that anti-inflammatory agents reduced depressive symptoms (SMD −0.55, 95% CI −0.75 to −0.35, I2=71%) compared with placebo. Higher response (RR 1.52, 95% CI 1.30 to 1.79, I2=29%) and remission rates (RR 1.79, 95% CI 1.29 to 2.49, I2=41%) were seen in the group receiving anti-inflammatory agents than in those receiving placebo. #medicalindustrialcomplex #placebo #antidepressants - jnnp.bmj.com Light works, Prozac ties placebo A total of 122 patients were randomized (light monotherapy, 32; fluoxetine monotherapy, 31; combination therapy, 29; placebo, 30). The mean (SD) changes in MADRS score for the light, fluoxetine, combination, and placebo groups were 13.4 (7.5), 8.8 (9.9), 16.9 (9.2), and 6.5 (9.6), respectively. The combination (effect size [d] = 1.11; 95% CI, 0.54 to 1.64) and light monotherapy (d = 0.80; 95% CI, 0.28 to 1.31) were significantly superior to placebo in the MADRS change score, but fluoxetine monotherapy (d = 0.24; 95% CI, −0.27 to 0.74) was not superior to placebo. #medicalindustrialcomplex #depression #sunlight #placebo #antidepressants #prozac - jamanetwork.com Clinical Trials of Therapy versus Medication: Even in a Tie, Medication wins | The BMJ The medical community strives to make decisions based on evidence, but as this case illustrates we have unfortunately arrived at a point where taking the conclusions of clinical trials at face value is apparently a sign of naivette. Conflicts of interest may play an important role in the reporting of scientific findings. The problem is not limited to just a couple of isolated cases but involves the entire culture of medicine that has developed over the past ten years. Put bluntly, the scientific machinery is broken. There is no easy fix, but surely patients deserve better. #medicalindustrialcomplex #pharma #antidepressants #bias - bmj.com ICER chastises J&J for overpricing depression drug esketamine 'where there is such need for treatment' – Endpoints News Using the esketamine list price of $295 per 28 mg intranasal device, the treatment's use results in an incremental cost-effectiveness ratio of approximately $198,000 per QALY compared to no additional treatment, exceeding the commonly cited cost-effectiveness thresholds of between $50,000-$150,000 per QALY. Meanwhile, esketamine is estimated to cost approximately $2.6 million per life year gained, ICER found. Esketamine's approval was also meant to enhance access to treatment — since ketamine is not covered by health insurers — although there is a concern that there may still be high out-of-pocket expenses through deductibles or non-coverage policies. Indeed, "the place for esketamine may depend on the comparative benefits between esketamine and other available treatments, such as ketamine. Unfortunately, such information is not available at this time," ICER said. #medicalindustrialcomplex #antidepressants - endpts.com (So does running) Ketamine reverses neural changes underlying depression-related behaviors in mice: Study sheds light on the neural mechanisms underlying remission of depression -- ScienceDaily Researchers took high-resolution images of dendritic spines in the prefrontal cortex of mice before and after they experienced a stressor. Dendritic spines are protrusions in the part of neurons that receive communication input from other neurons. The researchers found that mice displaying behaviors related to depression had increased elimination of, and decreased formation of, dendritic spines in their prefrontal cortex compared with mice not exposed to a stressor. This finding replicates prior studies linking the emergence of behaviors related to depression in mice with dendritic spine loss. In addition to the effects on dendritic spines, stress reduced the functional connectivity and simultaneous activity of neurons in the prefrontal cortex of mice. This reduction in connectivity and activity was associated with behaviors related to depression in response to stressors. Liston's group then found that ketamine treatment rapidly restored functional connectivity and ensemble activity of neurons and eliminated behaviors related to depression #pharma #hippocampus #antidepressants #dendrites #here-we-go-again - sciencedaily.com Gut Bacteria Linked to Depression Identified – Neuroscience News Mireia Valles-Colomer (VIB-KU Leuven): 'Many neuroactive compounds are produced in the human gut. We wanted to see which gut microbes could participate in producing, degrading, or modifying these molecules. Our toolbox not only allows to identify the different bacteria that could play a role in mental health conditions, but also the mechanisms potentially involved in this interaction with the host. For example, we found that the ability of microorganisms to produce DOPAC, a metabolite of the human neurotransmitter dopamine, was associated with better mental quality of life.' #depression #microbiome #dopamine #big-data #antidepressants - neurosciencenews.com The cumulative effect of reporting and citation biases on the apparent efficacy of treatments: the case of depression Figure 1 demonstrates the cumulative impact of reporting and citation biases. Of 105 antidepressant trials, 53 (50%) trials were considered positive by the FDA and 52 (50%) were considered negative or questionable (Fig. 1a). While all but one of the positive trials (98%) were published, only 25 (48%) of the negative trials were published. Hence, 77 trials were published, of which 25 (32%) were negative (Fig. 1b). Ten negative trials, however, became 'positive' in the published literature, by omitting unfavorable outcomes or switching the status of the primary and secondary outcomes (Fig. 1c). Without access to the FDA reviews, it would not have been possible to conclude that these trials, when analyzed according to protocol, were not positive. Among the remaining 15 (19%) negative trials, five were published with spin in the abstract (i.e. concluding that the treatment was effective). For instance, one article reported non-significant results for the primary outcome (p = 0.10), yet concluded that the trial 'demonstrates an antidepressant effect for fluoxetine that is significantly more marked than the effect produced by placebo' (Rickels et al., 1986). Five additional articles contained mild spin (e.g. suggesting the treatment is at least numerically better than placebo). One article lacked an abstract, but the discussion section concluded that there was a 'trend for efficacy'. Hence, only four (5%) of 77 published trials unambiguously reported that the treatment was not more effective than placebo in that particular trial (Fig. 1d). Compounding the problem, positive trials were cited three times as frequently as negative trials (92 v. 32 citations in Web of Science, January 2016, p < 0.001, see online Supplementary material for further details) (Fig. 1e). Among negative trials, those with (mild) spin in the abstract received an average of 36 citations, while those with a clearly negative abstract received 25 citations. While this might suggest a synergistic effect between spin and citation biases, where negatively presented negative studies receive especially few citations (de Vries et al., 2016), this difference was not statistically significant (p = 0.50), likely due to the small sample size. Altogether, these results show that the effects of different biases accumulate to hide non-significant results from view. #medicalindustrialcomplex #pharma #science #antidepressants #bias #confirmation-bias - cambridge.org You Can't Cure Depression By Working Out - Tonic Our two proven treatment paths for psychiatric illnesses are medication and therapy. People have messed around with the possibility of a third (electroconvulsive therapy, heat therapy) but we don't currently have one, no matter how many people say running eases their nerves better than medication. #medicalindustrialcomplex #antidepressants - tonic.vice.com SSRIs a 'Double-Edged Sword' in Major Depression? Investigators led by Igor Branchi, PhD, Center for Behavioral Sciences and Mental Health, Istituto Superiore di Sanità, Rome, Italy, explored the hypothesis that SSRIs may not "affect mood per se but [may amplify] the influence of living conditions on mood." #medicalindustrialcomplex #antidepressants #SSRI - medscape.com How does helping people affect your brain? Study shows neurobiological effects of giving social support -- ScienceDaily "Humans thrive off social connections and benefit when they act in the service of others' well-being," according to the authors. A previous study by Dr. Inagaki, also published in Psychosomatic Medicine, found that giving social support has positive effects on brain areas involved in stress and reward responses. That study suggested that providing support -- not just receiving it -- may be an important contributor to the physical and mental health benefits of social support. #community #antidepressants #gratitude - sciencedaily.com In test with rats, cannabidiol showed sustained effects against depression for seven days -- ScienceDaily "The forced swim test is used to measure the effect of antidepressant drugs because all known antidepressants shorten the duration of immobility and hence lengthen swim time. A reduction in immobility time in this test is interpreted as 'antidepressant-like' behavior." The researchers found that cannabidiol induced acute and sustained antidepressant-like effects in mice submitted to the forced swim test. "However, to make sure this result isn't due to the increase in movement caused by a psychostimulant effect leading the animals to swim more vigorously, for example, we performed a separate test to control for locomotor activity," Joca explained. "To do this we used the open-field test, which consists of putting the animal in a novel arena and letting it explore the new environment freely while its locomotor and exploratory activity is recorded. A drug is said to have potential antidepressant effects if it reduces immobility time and increases swim time in the forced swim test without increasing locomotor activity in the open-field test, showing that the effects observed in the forced swim test aren't secondary to nonspecific alterations in locomotor activity." #antidepressants #health/weed #cannabinoids - sciencedaily.com Painting a Nuanced Picture of Brain System Regulation Moods and Movements - Neuroscience News In a series of behavioral tests, the scientists also showed that serotonin neurons from the two groups can respond differently to stimuli. For example, neurons in both groups fired in response to mice receiving rewards like sips of sugar water but they showed opposite responses to punishments like mild foot shocks. "We now understand why some scientists thought serotonin neurons are activated by punishment, while others thought it was inhibited by punishment. Both are correct – it just depends on which subtype you're looking at," Luo said. #paleotherapy #anxiety #pharma #antidepressants #serotonin #SSRI - neurosciencenews.com Lack of a Single Molecule May Indicate Severe and Treatment Resistant Depression - Neuroscience News Naturally produced by the body, LAC performs a number of crucial tasks in the brain. For example, the molecule regulates energy metabolism and interacts with DNA to promote the expression of important genes. Specifically, it acts on a gene that controls levels of the neurotransmitter glutamate–a chemical implicated in almost everything that the brain does. McEwen, the Alfred E. Mirsky Professor, and Nasca, a postdoctoral fellow of the American Foundation for Suicide Prevention, have studied the link between LAC and mood disorders using animal models. In one study, they showed that LAC supplements ameliorate depressive symptoms in mice by reversing brain-cell impairment caused by an excess of glutamate. In a separate rodent study, they observed that LAC treatment reduces depressive behavior and stress-associated neural dysfunction in the medial amygdala, a brain region involved in social interactions. These findings strongly suggest that LAC deficits contribute to a depression-like state in mice, leading the scientists to wonder whether the molecule plays a similar role in humans. #depression #antidepressants #glutamate - neurosciencenews.com Association of Depressive Symptoms and Heart Rate Variability in Vietnam War–Era Twins: A Longitudinal Twin Difference Study | JAMA Psychiatry | JAMA Network The association between depression and autonomic dysregulation, indexed by HRV, is bidirectional, with stronger evidence suggesting that autonomic function affects depression risk rather than vice versa. #depression #antidepressants #hrv - jamanetwork.com The immune system and the pathogenesis of depression There is bidirectional communication between the HPA axis and the immune system. Cytokines activate the HPA axis and thus lead to the release of cortisol, the stress hormone, which ordinarily suppresses the immune response. Cortisol also inhibits its own release and thus the body is able to maintain a stable immune response through a tightly regulated feedback inhibition system. This regulation mechanism seems to be dysfunctional in depressive disorders and is thought to occur because of cytokine mediated receptor resistance to cortisol, thus impairing feedback inhibition. This essentially means that cytokines make cortisol unable to act on the receptors that would inhibit its release. Long story short — the HPA axis is hyperactive because of cytokines, leading to a chronic stress response because cytokines impair the body's ability to regulate it — thus leading to depressive symptoms. #depression #immune-system #antidepressants #cortisol #cytokines #HPA - medium.com Ketamine Acts Fast to Treat Depression and Its Effects Last, But How? - Neuroscience News Ketamine produces rapid and robust antidepressant effects in depressed patients within hours of administration, often when traditional antidepressant compounds have failed to alleviate symptoms. We hypothesized that ketamine would translocate Gαs from lipid rafts to non-raft microdomains, similarly to other antidepressants but with a distinct, abbreviated treatment duration. C6 glioma cells were treated with 10 µM ketamine for 15 min, which translocated Gαs from lipid raft domains to non-raft domains. Other NMDA antagonist did not translocate Gαs from lipid raft to non-raft domains. The ketamine-induced Gαs plasma membrane redistribution allows increased functional coupling of Gαs and adenylyl cyclase to increase intracellular cyclic adenosine monophosphate (cAMP). Moreover, increased intracellular cAMP increased phosphorylation of cAMP response element-binding protein (CREB), which, in turn, increased BDNF expression. The ketamine-induced increase in intracellular cAMP persisted after knocking out the NMDA receptor indicating an NMDA receptor-independent effect. Furthermore, 10 µM of the ketamine metabolite (2R,6R)-hydroxynorketamine (HNK) also induced Gαs redistribution and increased cAMP. These results reveal a novel antidepressant mechanism mediated by acute ketamine treatment that may contribute to ketamine's powerful antidepressant effect. They also suggest that the translocation of Gαs from lipid rafts is a reliable hallmark of antidepressant action that might be exploited for diagnosis or drug development. #antidepressants #SSRI #ketamine - neurosciencenews.com Antidepressants don't work, or depression doesn't exist (as a meaningful category) The real truth isn't found within the published paper but rather within a busy table on page 142 of the online appendix. It is here where the authors report what we want: the actual difference between drugs and placebo, before and after treatment, on the depression rating scales. Here we see that the Cohen's d standardized mean difference effect sizes range from a low of 0.19 to a high of 0.62 with amitriptyline. Thus, amitriptyline exceeds the clinically meaningful threshold of 0.50, with a traditional meta-analytic method. No other drug does so, with the closest second place being fluvoxamine, with a Cohen's d value of 0.44. Looking at all of the agents, 10 drugs have Cohen's d values less than 0.30, which is very small and clinically meaningless, whereas four have effect sizes from 0.30 to 0.34. Thus, 74% (14/19) of antidepressants clearly have little or no clinically important benefit in this analysis (for some reason, no data are provided in this table with two of the drugs). Four drugs have effect sizes of 0.37-0.44, and as noted, one agent exceeds the 0.50 threshold (amitriptyline). Perhaps a clearer conclusion than anything else is the well-proven fact that the tricyclic antidepressants are more effective than newer agents (there were no monoamine oxidase inhibitors in this meta-analysis). #medicalindustrialcomplex #depression #pharma #antidepressants #malpractice - medscape.com Lessons learned from placebo groups in antidepressant trials The analysis of 'nocebo effects', e.g. adverse effects in placebo groups of antidepressant trials also confirms the impact of expectations: nocebo symptoms reflected the typical side-effect patterns expected in the drug group, with higher symptoms rates in the placebo groups of tricyclic antidepressant trials compared with placebo groups of trials testing selective serotonin reuptake inhibitors. #medicalindustrialcomplex #placebo #antidepressants - ncbi.nlm.nih.gov Antidepressants and bladder medicines linked to dementia in landmark study -- ScienceDaily "We studied patients with a new dementia diagnosis and looked at what anticholinergic medication they were prescribed between four and 20 years prior to being diagnosed. "We found that people who had been diagnosed with dementia were up to 30 per cent more likely to have been prescribed specific classes of anticholinergic medications. And the association with dementia increases with greater exposure to these types of medication. "What we don't know for sure is whether the medication is the cause. It could be that these medications are being prescribed for very early symptoms indicating the onset of dementia. #medicalindustrialcomplex #antidepressants #Alzheimers - sciencedaily.com Antidepressant withdrawal About half (54%) met their goal of completely discontinuing one or more medications; 46% reported another outcome (use was reduced, use increased, or use stayed the same). Concerns about medications' effects (for example, long-term effects and side effects) prompted the decision to discontinue for 74% of respondents. They used various strategies to cope with withdrawal symptoms, which 54% rated as severe. Self-education and contact with friends and with others who had discontinued or reduced medications were most frequently cited as helpful. Although more than half rated the initial medication decision with prescribers as largely collaborative, only 45% rated prescribers as helpful during discontinuation. Of respondents who completely discontinued, 82% were satisfied with their decision. #medicalindustrialcomplex #antidepressants - ps.psychiatryonline.org Men and women have opposite genetic alterations in depression: A study examines the sex-specific molecular changes in major depressive disorder -- ScienceDaily Most of the genes that had altered expression were changed in only men or only women. However, genes that were altered in both men and women were changed in opposite directions. Women had increased expression of genes affecting synapse function, whereas men had decreased expression of the same genes. Women had decreases in genes affecting immune function, whereas men had increased expression of these genes. Additionally, the researchers applied their methods to data from a different set of subjects and replicated the opposing changes. #medicalindustrialcomplex #depression #antidepressants - sciencedaily.com Psychiatric Medications Kill More Americans than Heroin According to data from the MEPS (Medical Expenditure Panel Survey) database, the number of prescriptions for psychiatric medications (i. e. sedatives, antidepressants, psychostimulants, and antipsychotics) increased 117% between 1999 and 2013, from 197,247,557 prescriptions in 1999 to 427,837,506 prescriptions in 2013. Meanwhile, death rates from psychiatric medication overdose climbed a whopping 240% over the same time period, from 1.31 deaths per 100,000 in 1999 to 4.46 deaths per 100,000 in 2013 (we are excluding the CDC death rate data from 2014 since the MEPS 2014 data has not yet been published). #medicalindustrialcomplex #antidepressants - rehabs.com 2008 -- long term use of antidepressants More than 60% of Americans taking antidepressant medication have taken it for 2 years or longer, with 14% having taken the medication for 10 years or more. #antidepressants - cdc.gov Heart attack patients prescribed antidepressants have worse one-year survival -- ScienceDaily After adjusting for baseline characteristics the researchers found that the rates of stroke and subsequent heart attacks were similar between the two groups, but patients prescribed antidepressants had significantly worse survival. The rate of all-cause mortality at one-year after discharge was 7.4% in patients prescribed antidepressants compared to 3.4% for those not prescribed antidepressants (p<0.001). Antidepressant prescription was an independent predictor for mortality, and increased the odds by 66% (odds ratio: 1.66; 95% confidence interval: 1.16 to 2.39). #medicalindustrialcomplex #depression #paleotherapy #antidepressants - sciencedaily.com Get an email when henry copeland finds goodquotes on these topics: Subscribe All digiceuticals x45 mediumismedicine x3 medicalindustrialcomplex x227 inflamation x48 tinnitus x4 p-value x1 statistics x2 whichworksbest x2 AI x28 statins x4 carbs x9 circadian x67 diabetes x55 racism x25 silent-sam x2 the-south x11 23andme x17 China x3 privacy x12 DIY x6 food x75 history x80 n-of-1 x11 managing x220 robots x11 brain x140 lithium x7 medicine x42 ehr x3 hippocampus x38 maps x38 memory x96 neurons x101 growth x5 more-moore x14 friends x24 mirror-neurons x7 synchronize x183 apnea x6 infection x11 vaccines x1 cancer x27 fiber x3 microbiome x51 cvs x1 health-apps x6 sleep x72 generics x2 addiction x70 ADHD x67 dopamine x41 pain x20 placebo x28 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Calendula (Calendula officinalis)
Balancing Qualities:
This essence releases tension and is comforting, centering and balancing. It offers safety through its ability to create strong electromagnetic boundaries. This helps one be present and opens one to being able to receive and be nurtured. It also helps one be nurturing to one's self. It helps one be in touch with one's truth and be able to effectively express that truth. This enhances ease and confidence in communication and thus helps one feel empowered.
For those who feel internal pressure building up, manifesting as frustration and stress. They then are apt to use sharp or cutting words, be argumentative and turn away from receptive communication. This creates an unstable energy where there is a need for grounding, self reflection and protection. There may be a feeling of not being safe in one's body for no known reason.
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