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Eating (Or rather, Fasting) Our Way to Rejuvenated Stem Cells?
Could dietary interventions like intermittent fasting improve the activity of stem cells, normally impaired with aging? New research led by Omer H. Yilmaz at MIT reveals that fasting may improve intestinal stem cell function, by helping you burn fats for fuel.
Researchers at MIT, the Duke University School of Medicine and the Whitehead Institute for Biomedical Research in Cambridge recently published a short article in Cell Stem Cell revealing that part of this puzzle may be fatty acid oxidation inside of our mitochondria. Omer H. Yilmaz and colleagues found that a 24-hour fast in mice induces fat breakdown in intestinal stem and progenitor cells. This fatty acid oxidation appears to in turn improve the function of stem cells, even in aged mice.
"My lab is really interested in understanding how diet, in general, can be used to improve tissue function," Yilmaz said. "One of the tissue types I study is the intestine. In my lab we study the intestine because it's one of the largest organs in the body. It's also a tissue that experiences rapid cellular turnover."
The intestine is lined by a single layer of cells, Yilmaz explains, that turns over every 5 to 7 days. The workhorses of the intestinal lining and this cellular turnover are intestinal stem cells. These cells must retain a high level of function or cellular health in order to replenish the intestinal epithelium on a regular basis. Intestinal stem cells are particularly important in terms of repairing intestinal damage caused by gut infections and chemotherapy, for example.
"As we age, stem cells in the intestine as well as in many other tissues of the body, including in the blood and nervous systems, become less functional," Yilmaz said. "We believe that reduced adult stem cell function contributes to some of the decline of function associated with old age. My lab is very interested in studying low-calorie interventions to delay this decline. As a field, we've known for over 100 years that low-calorie states such as fasting or caloric restriction can have positive effects on tissue health and aging. We've seen evidence that fasting during times of intestinal infections that lead to diarrhea may promote healing of the intestinal lining, for example."
But researchers have yet to nail down the cellular mechanisms of how caloric restriction or fasting interventions lead to tissue regeneration, particularly through stem cell activity. To answer this outstanding question, Yilmaz and colleagues fasted mice for 24 hours to study how the fasted state impacts intestinal stem cells. They found that a single fast augments intestinal stem cell function in both young and aged mice, by boosting fat metabolism. It appears that using fats for energy preserves the health and function of intestinal stem cells, and that the ability to break down and use fats for energy is impaired in older individuals — unless they fast.
"Acute fasting regimens have pro-longevity and regenerative effects in diverse species, and they may represent a dietary approach to enhance aged stem cell activity in tissues." — Cell Stem Cell, 2018
"Our results were quite surprising — a single 24-hour fast dramatically improved the function of stem cells regardless of age," Yilmaz said. "We saw an improvement in stem cell function in young mice that were fasted, but more importantly a dramatic improvement in stem cell function in aged mice that were fasted."
Yilmaz and colleagues also found that if they damaged the intestines of mice, the fasted mice's intestines recovered much more quickly than mice fed ad libitum.
Happy Stem Cells Run on Fat
Yilmaz recognized that he had discovered a very interesting phenomenon, where some period of fasting seemed to have beneficial effects on stem cells in both young and older individuals. But what mechanisms were at play? Through clever experimentation, the researchers discovered that fatty acid oxidation may be the cause of improved stem cell function in fasted mice. When Yilmaz and colleagues turned off fat metabolism through genetic engineering, they were able to block the benefits of fasting on the mice's intestinal stem cells.
"If you look at the Western diet, under normal dietary conditions we and our cells derive about 60 to 70 percent of our energy from carbohydrates or sugar, about 20 percent from fat, and the remainder from amino acids," Yilmaz said. "What's really interesting is that when you fast, you start to derive much more energy, respectively, from the breakdown of fat. What we think is happening in our mice is that during fasting, the intestinal stem cells in both young and old animals switch from utilizing carbohydrates to using fat as a primary energy source, and that this metabolic switch is driving an improvement in stem cell function."
The researchers don't know yet exactly what is happening downstream of fat metabolism that is improving stem cell function in response to fasting, but they are on the hunt for the molecular players. Stem cells may function better when burning fats for fuel, but lose the ability to metabolize fats efficiently as they age.
"We know that the utilization of fat for energy in stem cells is associated with improved function; the next step is to work to understand why that is," Yilmaz said.
"Fasting increases FAO [fatty acid oxidation] in ISCs [intestinal stem cells] by driving both a robust PPAR-mediated FAO program in ISCs and by increasing circulating levels of triglycerides and FFAs [circulating free fatty acids] that can be then used by cells to generate acetyl-CoA for energy." — Cell Stem Cell, 2018
Keto diets have been used clinically to treat patients with seizures and related disorders for decades. Improvements in neurological symptoms that accompany keto diets and intermittent fasting have been associated with ketone bodies produced during the metabolism of fats and their use as an energy source in the brain. But it's not clear exactly how fatty acid oxidation contributes to rejuvenation in other tissues in response to fasting.
Fasting has also been associated with cellular turnover through autophagy or the dying off of aged, senescent cells that are damaged and can no longer divide. By selectively targeting senescent cells, fasting may improve tissue function such as that seen in the fasted mice's intestines. However, Yilmaz says, a 24-hour fast for a mouse is short in the grand scheme of things. It's unlikely that the observed improvement inintestinal tissue and stem cell function within that time frame would be primarily due to a clearing out of damaged, pro-inflammatory senescent cells.
"We think we are improving the quality of the existing stem cells, rather than generating new stem cells under these conditions," Yilmaz said. "But with these types of interventions, there's never one simple answer. Autophagy or the clearing out of senescent stem cells could be contributing to this improvement. However, we didn't see any significant increase in cell death of intestinal stem cells in our fasted mice."
If, as Yilmaz suspects, fasting is able to improve the function of existing intestinal stem cells in mice through fat metabolism, then the mitochondria in these cells, the "energy powerhouses" responsible for producing cellular energy, are key players. Fat metabolism occurs in mitochondria, where fat that enters the cell is immediately shuttled for breakdown and "burning." Impaired energy production as a result of aging and dysfunctional mitochondria might be a reason why human brains are susceptible to age-related diseases — and why fasting and fatty acid oxidation have been associated with cognitive improvements.
A Pill for Fasting?
Even though fasting is a relatively simple health intervention, not everyone can or should practice long fasts. For example, fasting is contraindicated for Type 1 diabetics, pregnant women, and other individuals suffering from malnutrition or muscle wasting. Yilmaz is investigating whether some of the metabolic benefits of fasting might be activated synthetically, or with drugs that drive fatty acid oxidation.
"At the end of the day, fasting may be a powerful health intervention, but it requires a lot of discipline. Fasting for 24 hours is a huge task," Yilmaz said. "But if we drive fatty acid oxidation with a drug that turns on genes associated with fat metabolism, we are able to reproduce much of the benefit we observe from fasting mice for 24 hours."
Ketone supplementation, on the other hand, may be tricky. Most ketones supplements are likely to be unstable in the bloodstream, Yilmaz says. If you take ketones artificially, you'll probably end up peeing most of them out within a short period, he says. We likely need more research in this area to justify ketone supplementation as an alternative to or driving of fasting benefits. The drug Yilmaz used to reproduce the metabolic health and intestinal tissue function benefits of fasting in mice actually turns on or activates genes that ultimately help break down fat. However, there are still unknowns in terms whether such drugs could have unintended consequences in humans who were still consuming a diet high in carbohydrates and sugars.
All animal studies have limitations in terms of translating the findings to humans. One limitation that stands out for this study is that a 24-hour a fast for a mouse is equivalent to a much longer fast in a human — a mouse fasted for 24 hours loses 3 to 5 percent of its body mass. But Yilmaz says that there are some very strong hints from a range of research studies that fasting on the range of 24 hours in humans has health benefits.
"What is the optimal period of fasting for humans? There's probably not one answer to this question to fit everyone," Yilmaz said. "I think the important thing is knowing that skipping a meal every now and then will likely be good for one's health. This is an area where we need more high-quality controlled studies in humans, but it's difficult to recruit large numbers of patients for fasting intervention studies."
Yilmaz is also now studying whether a ketogenic diet and 24-hour fasting may have similar effects on the function of intestinal stem cells in mice, or if fasting has unique benefits.
Yilmaz himself practices intermittent fasting on a regular basis, including over Ramadan for 17–18 hours per day. He was even fasting while conducting the interview for this blog post!
"This definitely isn't a controlled study, but I feel really good while fasting," Yilmaz said. "I feel more alert, and healthy — you get used to it over time. I should take an intestinal biopsy to see what my intestinal stem cells look like and how they function while I'm fasting!"
Learn more about intermittent fasting and harness meal timing for health with the LifeOmic LIFE Fasting Tracker mobile app.
Life and Tech @ LifeOmic
LifeOmic and LIFE Fasting Tracker blog


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Video from the chase shows that Officer Louis "Law" Abner Jones did not turn on his cruiser's lights to indicate that he was attempting to pull Tucker over, and that the man was stopping at stop signs and using turn signals. The police described Tucker ramming his truck into a police vehicle and then turning his wheels towards Officer Jones, however the family has cited the dashcam footage to dispute this claim.
Jones proceeded to shoot into the vehicle three times, hitting Tucker in the neck and his torso. He was pronounced dead at the scene.
"Officer Jones is trained and coached to twist the records, the facts, the circumstances to claim immediate peril, fear and harm to justify his unlawful actions and the use of excessive and unjustified deadly force," the family's lawsuit stated.
They ultimately settled their suit for $100,000, but the death was ruled justified and Officer Jones was cleared of any wrong-doing.
Now, six years later, the man who took Joey Tucker's life has taken to Facebook to mock the still-grieving family on their "Justice for Joey Tucker" memorial page.
Under the username "Law Jones," the officer posted to the page: "What justice do you seek?" he asked in the comments. He continued on, writing, "please tell me what justice you want SO bad..that you settled this for 100k… when you started at 7.5 mill… speak to my face about what you want, what justice..your sons life was only worth 100k…[sic]"
"It's sick. It's like the way a serial killer taunts his victims," Tucker's sister Melinda told the Fifth Column News.
In 1995, Jones sued to get his job back after being terminated by a Citizens Review Board for allegedly attempting suicide in the driveway of a dispatcher's home. The officer had reportedly driven erratically across the woman's yard and threatened to crash his vehicle through her house.
Jones' boss had determined that he was "not fit to be a police officer," and was a "crazy man" who was "dangerous." Jones won the lawsuit and was reinstated to the force. He received only a 6-month suspension for the incident.


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A group of 13 asylum-seekers who fled from Vietnam to Cambodia over the past two years to apply for refugee status returned to their home countrys central highlands on Tuesday morning, after the Interior Ministry completed interviewing the entire group of 167 last week.
The U.N.s High Commisioner for Refugees (UNHCR) transported the group of 13 through Ratanakkiri provinces Oyadaw border checkpoint, where Vietnamese officials picked them up and returned them to their hometowns, according to the agencys regional spokeswoman, Vivian Tan.
The Interior Ministrys refugee department finished interviewing the entire group of 167 asylum- seekers from the region on Friday, said Tan Sovichea, the departments director.
We have not yet determined how many people passed and how many people failed, he said. We are now evaluating each case to determine the status of asylum- seekers, and then we will send them case by case to be evaluated by the interior minister for a final decision.
Mr. Sovichea added that he did not know when the evaluation process would be complete, but said the majority of the group would likely have their applications rejected.
The U.N.s involvement in the process has been controversial, with human rights advocates saying that Cambodia is not giving proper consideration to the asylum-seekers due to political pressure from Vietnam.
The UNHCR has said its assistance is conditional upon Vietnam allowing the agency to follow up with the returned Montagnards to ensure they are not being persecuted. Ms. Tan of the UNHCR said groups that have been returned over the past year seem to have settled back in their villages with no significant problem.
Denise Coghlan, head of the Jesuit Refugee Service, which has been providing assistance to the Montagnards in Phnom Penh, said one family among the 13 people had appealed their rejection before being returned to Vietnam.
As the UNHCR continues monitoring those that have been returned, she said, they may keep a special look-out for that case.
firstname.lastname@example.com, email@example.com
© 2016, The Cambodia Daily. All rights reserved. No part of this article may be reproduced in print, electronically, broadcast, rewritten or redistributed without written permission.The post With Interviews Concluded, 13 Montagnards Return to Vietnam appeared first on The Cambodia Daily.


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Age of Innocence
Contest Finalist in Teenage Portraiture Photo Contest
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RuwanFonseka May 06, 2016
Excellent pose focus and lighting.
normg123 June 08, 2016
Wonderful shot, but those lights in the eyes are distracting.
john_arsenault June 28, 2016
the perils of having a wireless mouse with a low battery. i am not sure what i awarded this image, but it should have been "Masterpiece" for its perfect exposure, clarity of image, use of depth of field, and compelling expression of the model that the photographer captured so beautifully.
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I love the lights in the eyes. I wouldn't be distracted by the comment by normg123. Congratulations on a beautiful image
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rindrarandhy October 07, 2016
Wow! Stunning!
siegart October 26, 2016
stunning. Amazing Photo, amazing editing. great tones
mdelee October 28, 2016
great portrait!! i love the DOF.
pacinodeppfan1 April 07, 2017
Very Pretty Girl!
pacinodeppfan1 April 07, 2017
This image looks like the Les Miserables (2012) movie poster!
zoeseitis May 04, 2017
Looks like Cosette from Les Miserables :)


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We always love to hear your positive comments about us and here are a few things that people say about the yogurts we make.
If you would like to let us know what you think of our yogurt please email here.
I wanted to write to you just because your Greek Style Vanilla yogurt, well, it's amazing. I don't mean "amazing" in the sense "well gee that's quite nice" – I mean IT'S FREAKING AMAZING!
It's honestly the nicest yogurt I've EVER tasted. Proper "Oh. My. God. This is good" style. Well done on such a great product!
Andrew O'Connell
I would just like to congratulate you on your superb tasting creamy yogurt. I have tried two flavours so far, Vanilla and Honey and I have to say they're the best I've ever tasted. (I have two more flavours in the fridge!) I hope they become more widely available but without compromising the excellent quality. They are my go to yogurt from now on!
Liam Keane
After a very serious operation I was advised to try your yogurt – with Honey. 3 months on I am addicted to it and spreading the word about it. Thank you so much
Nina Barker
Just tried your Greek Style Yogurt with Honey for the first time. I usually buy Rachels or Yeo, but after tasting yours there's no going back! So thick and creamy and tastes absolutely wonderful. Well done on a fabulous product . Will be recommending to all my friends and family
Mrs Lorraine Armer
Stunning Yogurt! Healthy and Amazing
Tims Dairy is the best British made Greek yogurt I've tasted. I've had the one with added honey and some homemade granola this morning
Glenn Parsons
My absolute favourite is blackcurrant and I have one everyday for breakfast. When they are on the shelf I buy the lot! I just wanted to let you know how delicious they are. Keep up the good work!
This year, if I'm hungry and want a snack, I'm going to make a conscious decision to pick your yogurts over chocolate, biscuits, crisps etc!
The best yogurt I have tasted, so creamy
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I tell all my friends it's the best. I even tell complete strangers at the supermarket to buy it!
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My absolute favourite- best yogurt ever #fact
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© 1949-2019 Tims Dairy - By Kuro Kin


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Investing should be easy – just buy low and sell high – but most of us have trouble following that simple advice. There are principles and strategies that may enable you to put together an investment portfolio that reflects your risk tolerance, time horizon, and goals. Understanding these principles and strategies can help you avoid some of the pitfalls that snare some investors.
Events on Wall Street
Can successful investors predict changes in the markets? Some can but others miss the market's signals.
5 Smart Investing Strategies
Getting what you want out of your money may require the right game plan.
Have A Question About This Topic?
How Stocks Work
Understanding how a stock works is key to understanding your investments.
Estimating the Cost of College
This worksheet can help you estimate the costs of a four-year college program.
All Muni Bonds Are Not Created Equal
Gaining a better understanding of municipal bonds makes more sense than ever.
You Would Rather Be...
Are you a thrill seeker, or content to relax in the backyard? Use this flowchart to find out more about your risk tolerance.
The Investment Risk No One's Ever Heard Of
You face a risk for which the market does not compensate you, that can not be easily reduced through diversification.
Best-Performing Asset Classes
Bonds may outperform stocks one year only to have stocks rebound the next.
View all articles
How Compound Interest Works
Use this calculator to better see the potential impact of compound interest on an asset.
Saving for College
This calculator can help you estimate how much you should be saving for college.
What Is the Dividend Yield?
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Keys to Investing for Retirement
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5 Smart Investing Principles
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5 Smart Investing Strategies
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From Boats to Brokers
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Antiquities Site Inventory: Cr Report 3-584(N)
Author(s): Michael J. McCollister
Year: 1975
This resource is a citation record only, the Center for Digital Antiquity does not have a copy of this document. The information in this record has been migrated into tDAR from the National Archaeological Database Reports Module (NADB-R) and updated. Most NADB-R records consist of a document citation and other metadata but do not have the documents themselves uploaded.
If you have a digital copy of the document and would like to have it curated in tDAR, please contact us at firstname.lastname@example.com.
Cite this Record
Antiquities Site Inventory: Cr Report 3-584(N). Michael J. McCollister. 1975 ( tDAR id: 182567)
This Resource is Part of the Following Collections
Investigation Types
Site Evaluation / Testing
Significance / Management
Geographic Keywords
32005 (Fips Code) • Douglas (County) • Gardnerville QUAD • Nevada (State / Territory) • North America (Continent) • United States of America (Country)
Spatial Coverage
min long: -120.003; min lat: 38.535 ; max long: -119.31; max lat: 39.114 ;
Individual & Institutional Roles
Sponsor(s): Bureau of Land Management; BLM, Carson City, NV
Prepared By(s): BLM, Carson City, NV
Record Identifiers
NADB document id number(s): 1250532
NADB citation id number(s): 000000026125
General Note: Submitted to: BLM, Carson City, NV
General Note: Sent from: BLM, Carson City, NV


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|Lion King
Title screen.
|Hack of
|Chiki Chiki Machine Mou Race (Wacky Races)
|J.Y. Company
|Original developer
|Alternate names/hacks
|The Lion King (Cart label)
Lion King is a hack of Chiki Chiki Machine Mou Race (Wacky Races) for the Famicom. It was published in 1995 by J.Y. Company.
Overview Edit
Other than changing the title screen, the game changes Muttley to Simba instead. (However, on the title screen Muttley can still be seen riding with Dick Dasterdly.) The bark graphic has also been changed from "BOW" to a graphical effect. Some graphics have been removed such as the text for the map and the cutscenes, the dialogue windows and the checkered background used for the cutscenes.
Trivia Edit
- The known ROM of this game mentions "Chiki-Chiki Dog" in its name. That part was derived from part of the Japanese name and the fact you originally played as Muttley.
Gallery Edit
Community content is available under CC-BY-SA unless otherwise noted.


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In Lone Mountain Cemetery in San Francisco, California, lies murder victim Andrew Randall.
Born in Johnston in 1819, he lived long enough to learn that money is indeed the root of all evil.
The son of Samuel Randall and Marcy (Thornton), Andrew was living in Kentucky when he married Elizabeth Todd in 1844. The couple relocated to California, where Andrew worked as a medical doctor and geologist, eventually founding the California Academy of Science. Greatly successful in his career, he accumulated impressive wealth, which he spent purchasing a variety of ranches and parcels of land.
By 1854, however, he found himself unable to financially support all of his holdings and arranged to borrow $20,000 from Joseph Hetherington, another man of rich means, who had come to San Francisco in 1849. In his mid-30s and originally from Louisiana, Joseph was tall and handsome with wavy black hair, a thick beard and the finest of clothes. People liked him, and that earned him a lot of privileges.
The previous year, Joseph had entered into a land dispute with a Dr. Baldwin. By some error, both men held the deed to a certain tract of land. When Dr. Baldwin took it upon himself to erect a fence around the property, Joseph was furious and issued more than a few threats.
Fearing for his life, the doctor brought a gun with him when he visited the property. On one occasion, however, he left the gun sitting atop the fence while he and his entourage enjoyed what he deemed to be his property. Joseph showed up, grabbed the gun and threatened that anyone who didn't vacate the property would be shot. Dr. Baldwin paid no attention. Joseph pulled the trigger, but it stuck. He then slipped a revolver out of his pocket and shot the doctor in the arm.
Dr. Baldwin realized Joseph wasn't issuing idle threats, and he ran toward the fence and tried to climb over it. But Joseph shot again, hitting him in the back. Dr. Baldwin died three days later.
Joseph had immediately gone to police after the showdown and announced, "I shot Dr. Baldwin." Now that he was dead, a murder trial would go into effect. The proceedings were brief and, probably as he expected, Joseph was found not guilty.
Andrew Randall had handed Joseph the mortgage to a large parcel of land as a sort of promise that he would pay him back the $20,000 by a certain date. When the terms weren't meant, Joseph began legal proceedings to have the land transferred into his own name. Andrew was greatly distraught by this and took every delay tactic he could find to court with him, promising Joseph that if he just waited a short while longer, he would get his money.
But time lagged on, and Joseph finally threatened that if he didn't get the money or the land soon, he would shoot Andrew. Scared for his life, Andrew took his family and snuck out of town. When Joseph learned of this, his anger boiled over. He waited for Andrew to return and, eventually, he did.
Andrew was sitting inside the bar of the St. Nicholas Hotel on the afternoon of July 24, 1856, when Joseph suddenly walked in. He stormed up to him and grabbed him by the beard as he shouted insults.
Andrew pulled out a gun, but he was not quick enough. Joseph pulled out his own gun and fired five shots, the last one passing right through Andrew's brain. He died the following morning.
Joseph's wealth and popularity didn't save him this time. In the days to come, a gallows was erected on a public street and crowds gathered to watch Joseph Hetherington be executed for murdering Dr. Andrew Randall.
Kelly Sullivan is a Rhode Island columnist, lecturer and author.


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To solve this dining dilemma, we've gone ahead and put together a list of our favourite, must try, great-value feasts in the capital.Ranging from generously curated menus to 'all you can eat' options, every taste will be accounted for, and no tummy will be […] read more As a millennial and lover of a good drop, Canberra's Kata Cser was keen to take the stuffiness out of the wine industry with her new business, Wine Not The Brand. The possibilities surrounding the many ways to eat chips is about to blow your mind...
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From a Fully Loaded Pizza which you never knew existed, to getting your Parmesan fix with chips instead of pasta changes everything.
We scoured our favourite food blogs for the most amazing ways to to eat chips all day long.
While the Americanized version of this recipe typically calls for deep-fried chicken, Ching stir-fries her General Tso's chicken in a sweet and spicy sauce along with peanuts and scallions for a healthier and more authentic take on the recipe.
To make a really stand-out chow mein, start with high-quality noodles.
Last week, Caesars Atlantic City hosted a meet-and-greet with chef Gordon Ramsay at the Gordon Ramsay Pub & Kitchen restaurant inside the hotel. Then for my entree, since they had a wood-fired grill, I did a nice grilled sirloin with some Korean mushrooms in a little demiglace. I really loved that he went down the kitchen line and greeted every one of the kitchen crew.
Casino patrons and executives, media reps, and local dignitaries got to chat up the high-volume Scottish-born chef, who stars in the Fox chef-competition series Though she grew up in South Jersey and at the Jersey Shore, working at first as a preschool teacher, Leaming is familiar to city residents from Suppa (formerly in Northern Liberties) and, later, Samwich, at Sixth and Catharine Streets, both casual restaurants operated with her boyfriend, Angelo Polito. It's really picking up a lot of speed and getting well known for their food. Clearly, they have the different chefs come through here but most of them didn't have experience working a casino restaurant. It's more involved, between the union and the large volume. We're not making millions of dollars or anything over there. My former executive chef Rob Schoell — he's at Harrah's now — gave them my name because they were looking for somebody.Ching recommends using shi wheat flour noodles ("shi" means "thin" in Mandarin), which cook in only three minutes.Toss the noodles with crunchy vegetables and strips of spicy chicken in a wok for a few quick minutes and you've got yourself a "mein" dish that's as easy as it is healthy.Leaming and Polito met in 2011 while working at the Showboat Atlantic City Hotel. Then I left because at the time, I was getting separated and my daughter was turning 5.


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Mysuru, August 28:- "The Global Technology Centre- ''Raghupati Singhania Centre of Excellence' inaugurated today will be another feather to the cap of Mysuru," said Chief Minister H D Kumaraswamy.
He was addressing the gathering after inaugurating the new R&D facility at JK Tyres factory at Hebbal and the Raghupati Singhania Centre of Excellence (RPSCOE) in the city on Tuesday.
He said, "JK Tyres has done commendable work in Mysuru City and their work through Corporate Social Responsibility (CSR) activities is noteworthy. Mysuru houses many reputed institutions like CFTRI, BEML and Infosys. JK Tyres is another feather in the cap of heritage city. I appreciate JK Tyres and Raghupati Singhania for opening the Global Technology Centre and the new R&D facility in Mysuru. I want JK Tyres to formulate tailor-made courses through this centre for the youth of Karnataka and contribute to the economic and social development in Mysuru."
CM persuades JK Tyres to intervene, resolve Falcon Tyres row
Speaking on the occasion, Kumaraswamy made a personal appeal to Raghupati Singhania of JK Tyres with regard to Falcon Tyres row.
"Our government has the responsibility to address the issue of Falcon Tyres and give a solution to the problems faced by the factory employees. The workers are facing a lot of problems for their livelihood from the past few years. My government is open to JK Tyres company, whatever support is needed our government is open to extend and request JK Tyres to take all responsibility to safeguard the interest of Falcon employees," he added.
Higher Education Minister and District In-charge G T Devegowda, Sericulture and Tourism Minister S R Mahesh, Dr Raghupati Singhania, Chairman and Managing Director; Rajiv Prasad, Director – India Operations, V K Misra, Technical Director; Dr R Mukhopadhyay, Director and CE HASETRI and others were present. –(HN, KK)


text:
Note: Video is from 2010. The rest of the series can be found here. As usual, I'm posting this because I think it's interesting, not because I'm endorsing its views (or disputing them, for that matter). I'm not sure what the current state of research is, but the subject of Anasazi cannibalism was in dispute back in 2001, according to this story from National Geographic:
"Archaeologists argue bitterly over whether the ancient Anasazi, the ancestors of today's Pueblo Indians, routinely killed and ate each other. From one point of view, the evidence seems overwhelming: piles of butchered human bones, some of which were apparently roasted or boiled. In one instance, ancient human feces even seem to contain traces of digested human tissue.
"But from another standpoint, Anasazi cannibalism doesn't make sense. Eating people obviously isn't part of modern Pueblo culture, and local tribes are deeply offended by the suggestion that their Anasazi ancestors may have been cannibals. Many researchers argue that the marks attributed to flesh-eating could instead be created during slightly less gruesome activities, such as the public execution of suspected witches."
Comment: I have no idea whether the dispute has been settled one way or another. I only had time to do a cursory search, but the whole subject seems to have dropped off the radar. Whatever the case, the fact that these modern tribes don't eat people and are offended by the idea that their ancestors might have eaten people doesn't constitute evidence for or against Anasazi cannibalism. Those piles of butchered bones have to be explained somehow and I'm not sure that blaming them on "the public execution of suspected witches" does much to restore the Anasazis' image.


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Elia Kalamaki
- Free buffet breakfast, free WiFi, and free parking
- Collect nights
The staff are so friendly and helpful! They made my stay so enjoyable.
Loved the shower, good location. Service was delightful.
Elia Kalamaki
- Economy Double or Twin Room
- Standard Double Room, City View
- Standard Double Room, Sea View
- Superior Double Room, Sea View
- Junior Suite, City View
- Junior Suite, Sea View
More great choices
What's around Elia Kalamaki
- Golden Beach - 32 min walk
- Kalamaki Beach - 8 min walk
- Agioi Apostoloi Beach - 8 min walk
- Stalos Beach - 23 min walk
- Nea Chora Beach - 2.5 mi / 4 km
- Agia Marina Beach - 2.9 mi / 4.7 km
- Chania Lighthouse - 3.8 mi / 6.1 km
- Old Venetian Harbour - 4.1 mi / 6.6 km
Getting around
- Chania (CHQ-Ioannis Daskalogiannis) - 28 min drive
- Airport shuttle (surcharge)
At a glance
Key facts
Hotel size
- This hotel has 15 rooms
- Check-in time 2:00 PM-11:00 PM
- Check-out time is noon
If you are planning to arrive after 11:00 AM please contact the property in advance using the information on the booking confirmation.
Required at check-in
- Credit card or cash deposit required
- Government-issued photo ID required
- Minimum check-in age is 18
Travelling with others
- Pets not allowed
- Free WiFi in public areas
- Free WiFi in rooms
- Airport shuttle *
- Free self parking
- Free nearby parking
Payment types at the property
In the hotel
- Free buffet breakfast daily
- Outdoor pool
- Front desk (limited hours)
- Tours/ticket assistance
- Luggage storage
- Designated smoking areas
- Garden
- Terrace
- English
- Greek
In the room
- Air conditioning
- Espresso maker
- Bathrobes
- Slippers
- Soundproofed rooms
- Balcony
- Private bathroom
- Shower only
- Free toiletries
- Hair dryer
- Flat-screen TV
- Satellite TV channels
- Free WiFi
- Refrigerator
- Daily housekeeping
- In-room safe (laptop compatible)
Recommended hotels
Elia Kalamaki's small print
Also known as
- Elia Kalamaki Hotel Chania
- Elia Kalamaki Hotel
- Elia Kalamaki Chania
- Elia Kalamaki Hotel
- Elia Kalamaki Chania
- Elia Kalamaki Hotel Chania
Cash transactions at this property cannot exceed EUR 500, due to national regulations. For further details, please contact the property using information in the booking confirmation.
Only registered guests are allowed in the guestrooms.Guests must contact this property in advance to reserve cribs/infant beds. This property is licensed under an applicable law.
- Property Registration Number
- 4352
Optional extras
Cribs/Infant beds are available for EUR 7.0 per day
Airport shuttle service is offered for an extra charge
We have included all charges provided to us by this property. However, charges can vary, for example, based on length of stay or the unit you book.
Recent reviews
Exceptional 9.6 From 37 reviews
Excellent service by polite and helpful staff. Clean hotel with great amenities. A little further from old town than expected.
Nice place, very helpful and friendly staff and fantastic hospitality. Great value for money.
Our stay in this gem hotel is realy pleasant. Hotel is brand new everything was excellent, personell is realy helpfull and they realy take care of you. We like this place as it is very clean, brand new and close to small town.
Amazing experience at this lovely hotel. The staff who work there are so friendly and polite and can't do enough for you. The room was spacious, modern, clean and very well decorated. The breakfast was fantastic and the girls that worked breakfast were so lovely. Overall 5/5 experience and would definitely return in the future.
Service: TOP QUALITY. Everything else was FINE. This is a budget hotel, in a VERY BUDGET location. I was happy with the value I got, but note that this area is not the best in Crete and the hotel location while OK is not the best if you are staying for more than a couple of days. Having said that, facilities were fine and room was very nice and clean. So, overall I think I got what I paid for so I believe if you know what you are getting then go for it.
Is the description of this hotel not correct? Tell us


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Kevin Gates Issues A Defiant Response To Any Officer Who Harasses His Children
Kevin Gates isn't mincing words.
The Baton Rouge rapper who, if we're being honest, doesn't ever mince words, made it crystal clear what he would do if a police officer harassed one of his children. In a minute long- Instagram video that's circulating the Internet, Gates said he's willing to kill whoever to avenge the honor of his children if need be.
"B**ch, your whole family 'gon die, instantly," Gates says. "I'll set it." A n*** disrespect my son.; slap him, touch him, scratch him whatever, your family 'gon die instantly, ain't no ifs, ands or buts."
Gates is no stranger to eyebrow raising comments or behavior. In September 2015, footage surfaced of Gates kicking a female fan in the chest after she grabbed his pants leg during a performance in Florida.
The video merited a mix bag of reaction with some alleging Gates "wouldn't bust a grape in a fruit fight" to others who share his sentiments. We're not judging, so what say you? Think Gates is onto to something? sound off in the comments.


text:
Event Information
Date and Time
Refund Policy
Contact the organiser to request a refund.
Eventbrite's fee is nonrefundable.
About this Event
Of the original crop of Detroit DJs, Delano Smith is one of the few still dedicated to the craft. Reflecting on house and techno without his influence would reveal a very different musical landscape today. Coming up when the world was just discovering the impact a DJ could have, Delano traversed his way to the top in a tough scene full of talent.
Although dance music post The Belleville Three and Underground Resistance is well documented, the context that set the tone for them to emerge is less so. At a time described as the Wild West by some, when party culture was taking its first tentative steps, Delano honed his skills under the the guidance of the late, great Ken Collier. With initial sets fusing soul, disco and early electronic sounds, Delano planted seeds in the minds of Detroit's subsequent generations. Those dancing to his sets in the late 70s and early 80s would later become ambassadors of a scene with worldwide appeal. Now, Delano stands shoulder to shoulder with the figureheads he once educated, writing a brand new chapter for house and techno.
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First-Time Homebuyer The Ohio housing finance agency (ohfa) offers several affordable loan options to help you achieve your dream of homeownership. OHFA offers 30-year, fixed-rate FHA, VA, USDA-RD and conventional mortgage loans with generous income and purchase price limits designed especially for homebuyers with low- and moderate-incomes.
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Home Loan Estimator Based Income Income-Based Repayment (IBR) is a repayment plan available to federal student loan borrowers. It's based on the idea that how much you pay each month should be based on your ability to pay, not how much you owe. When applying for IBR, the government looks at your income, family size, and state of residence to calculate your monthly payments.Questions To Ask First Time Home Buyers Michele Lerner. Between organizing your financial documents, applying for a mortgage and scheduling an appraisal, the process can make your head spin. Asking some key questions along the way can make navigating the waters easier. There are some things that first-time buyers may be more likely to overlook.
And Fannie's MH Advantage program, to finance manufactured housing, also offers 97 LTV financing. Are conventional 97 LTV loans better than FHA? FHA-backed loans are still drawing the lion's share of.
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Veterans only; Does not have to be a first time homebuyer; VA 30-Year fixed loans only; 100% financing; Program Income limits Apply; Reservation fee $100.
Bad Time To Buy A House Even though many people are buying less expensive housing these days, you might be very tempted to buy a bigger house. I can understand that. Interest rates are ridiculously low and real estate prices seem to be just bottoming out. I recently wrote a post explaining that most people are far better o ff buying real estate rather than renting. I believe that with every cell of my body.House Loan Affordability Calculator Desired Loan Amount: preferred repayment period: loan tenure (monthly) 30 years 29 years 28 years 27 years 26 years 25 years 24 years 23 years 22 years 21 years 20 years 19 years 18 years 17 years 16 years 15 years 14 years 13 years 12 years 11 years 10 years 9 years 8 years 7 years 6 years 5 years 4 years 3 years 2 years 1 year
· First Time Home Buyers are not using FHA as the "go to" program, in part because FHA says you must be on a Level Payment plan that is fully amortized, or we must count 1% of the student loan debt against you.
Find the home buyer programs in your city and state. First time home buyer program, tax credits and grants are available to those who qualify.


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Autonomic modulation preceding the onset of atrial fibrillation
Author + information
- Published online October 1, 2003.
Author Information
- ↵*Reprint requests and correspondence:
Dr. William H. Maisel, Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA.
Autonomic influences on the heart have been recognized for many centuries. It was not until 1921, however, that a German physiologist named Otto Loewi stimulated a frog's vagus nerve, collected the released substance, and applied it to a second, different frog heart to demonstrate its effects. For his discovery of this "vagusstuff" (subsequently shown to be acetylcholine), Loewi (1)shared the 1936 Nobel Prize in Physiology or Medicine. We now know that acetylcholine released by the vagus nerve is the predominant parasympathetic influence on the heart while epinephrine and norepinephrine mediate the principal cardiac sympathetic effects (2).
The measurement of autonomic tone in humans noninvasively presented new challenges. Subtle beat-to-beat variations in heart rate are influenced by autonomic tone, giving rise to the measure of heart rate variability (HRV). That changes in the RR-interval (heart rate) precede and predict clinically relevant events was first appreciated in the mid-1960s when beat-to-beat variations in heart rate were shown to portend fetal distress (2). Later, it was appreciated that reduced HRV was an independent predictor of ventricular arrhythmias, sudden cardiac death, and total mortality after myocardial infarction and predicted increased mortality in other patient populations such as those with heart failure or diabetes (2–4).
Experimental studies utilizing vagus nerve stimulation, vagotomy, and muscarinic receptor blockade have demonstrated that efferent vagal activity contributes significantly to the high-frequency (HF) component of HRV (2). While interpretation of the low-frequency (LF) component of HRV is more controversial, most agree that at least some portion reflects sympathetic modulation of the autonomic nervous system (2). The LF/HF ratio is viewed by many, therefore, to represent sympathovagal "balance" (2). Importantly, HRV measures changes in the relative degree of autonomic modulation of heart rate, not the absolute level of sympathetic or parasympathetic tone.
In this issue of the Journal, Amar et al. (5)report the results of their investigation into the autonomic fluctuations preceding the development of postoperative atrial fibrillation (AF) in patients undergoing major thoracic surgery. They utilized HRV measures as an indicator of autonomic tone. Compared with control patients, those who developed AF had an increase in LF and HF power and a decrease in LF/HF ratio in the period preceding AF onset. These findings are consistent with activation of both the sympathetic and parasympathetic systems with a shift towards parasympathetic predominance. These findings add to the growing body of literature suggesting that autonomic influences play an important role in the initiation of AF.
A number of other studies have also demonstrated that fluctuations in autonomic tone, as measured by HRV, precede the onset of AF (6–10). Yet while these investigations consistently demonstrate that dynamic changes in autonomic tone occur prior to AF, the frequency, character, and degree of change varies considerably from study to study. For example, among patients with structurally normal hearts, some have observed an increase in vagal predominance in the minutes preceding AF onset, while others have noted a marked shift towards sympathetic predominance (10,11). Other patients with paroxysmal AF or AF triggered by pulmonary vein foci may experience a rise in sympathetic tone followed by a marked shift towards vagal predominance in the minutes preceding AF onset (6,7), findings more consistent with those of Amar et al. In contrast, patients undergoing cardiac surgery experience a relative decrease in vagal tone and an increase in sympathetic tone before developing AF (9). To explain these various observations, some have suggested that vagally mediated AF occurs most often in patients with normal hearts and occurs predominantly at night when vagal tone is relatively high, while adrenergically induced AF occurs more frequently in patients with organic heart disease and occurs more frequently during the day (11). However, not all studies support this simplified interpretation of the data. Indeed, there are many exceptions to this "rule."
A number of important electrophysiologic changes occur in atrial myocardium in response to an increase in vagus nerve activity. Acetylcholine, acting via its effect on muscarinic receptors, reduces the slope of spontaneous depolarization of the sinoatrial node pacemaker cells and results in a slowing of the heart rate. Acetylcholine also shortens the atrial refractory period and increases the heterogeneity of atrial refractoriness, effects that predispose to reentry (12,13). It appears that the relative sympathovagal balance is as important, or more important, than the absolute sympathetic or parasympathetic tone. Indeed, experimental regional cardiac denervation (e.g., withdrawal of sympathetic tone from a specific atrial site) can result in a relative increase in vagal tone without a change in the absolute vagal tone. This can result in regional shortening of the atrial refractory period, heterogeneity of atrial repolarization, and predisposition to induction of AF (14–16). This important interplay between sympathetic and parasympathetic tone is further underscored by the observation that AF induction in dogs occurs much more readily with infusion of isoproterenol and acetylcholine than with either isoproterenol or acetylcholine alone (17).
That increased vagal tone can predispose to the development of AF has been recognized since the initial description by Coumel et al. (18). Perhaps most exciting are the new therapeutic avenues that have been opened by our increased understanding of the autonomic influences that predispose to AF. Parasympathetic ganglia have been localized to discrete epicardial fat pads. Radiofrequency ablation of specific fat pads causes regional alterations of cardiac parasympathetic tone and, as a result, affects atrial refractory periods, atrioventricular nodal conduction properties, and heterogeneity of atrial conduction (15,19,20). In dogs, catheter ablation of parasympathetic nervous input to the atrium can abolish vagally mediated AF (21).
Loewi's (1)initial description of "vagusstuff" opened the door to important advances in our understanding of cardiac autonomic regulation. Similarly, improved understanding of the autonomic influences that predispose to AF will be critical to the development of novel therapies. While there is much that remains to be learned, specific pharmacologic, catheter, or device-based therapies that alter or regulate autonomic tone may someday prove to be useful weapons in the battle against AF.
↵* Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
- American College of Cardiology Foundation
- ↵Loewi O. The Nobel Prize in Physiology or Medicine: Nobel Lecture. December 12, 1936. Available at: www.nobel.se/medicine/laureates/1936. Accessed on March 24, 2003
- ↵
- Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology
- Lombardi F.
- ↵Amar D, Zhang H, Miodownik S, Kadish AH. Competing autonomic mechanisms precede the onset of postoperative atrial fibrillation. J Am Coll Cardiol 2003;42:1262–8
- ↵
- Bettoni M.,
- Zimmermann M.
- Wen Z.C.,
- Chen S.-A.,
- Tai C.-T.,
- Huang J.-L.,
- Chang M.-S.
- ↵
- ↵
- ↵
- ↵
- Wang J.,
- Liu L.,
- Feng J.,
- Nattel S.
- Ninomyia I.
- ↵
- Olgin J.E.,
- Sih H.J.,
- Hanish S.,
- et al.
- ↵
- Chen Y.J.,
- Chen S.-A.,
- Tai C.-T.,
- et al.
- ↵
- ↵
- Chiou C.-W.,
- Eble J.N.,
- Zipes D.P.
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- Schauerte P.,
- Scherlag B.J.,
- Pitha J.,
- et al.


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Tornado touches down in Bakersfield
BAKERSFIELD, Calif. (KTVU) - The Central Valley was hit by a rare tornado over the weekend.
The twister touched down in an open field in Bakersfield at 5:19 p.m. on Sunday.
Local forecaster and anchor Aaron Perlman of Eyewitness News told KTVU it was the fifth tornado ever recorded in the immediate Bakersfield area.
Witnesses said they saw a funnel make contact with the cloud and the ground, as debris and dust spit out from the funnel.
There were no reports of damage or injuries.
It wasn't the only notable weather event that hit the region on Sunday.
"This was also the first time we had measurable rain in Bakersfield for June in 4 years!" Perlman said. "Last time was June 28, 2015... with a trace."


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55318 Area, Get Tires & Auto Repair Services
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text: August was all about reading some great books and spending a lot of quality time with friends. After all, it is the month when we celebrate Friendship day 😉 Trips I made in August: We had a few trips to enjoy the monsoons with family and friends. The first one was to Bhandardara and you … Continue reading Life Diaries and Reading Wrap Up – Aug 2019


text: Lake Macquarie City Council operates the Lake Macquarie Youth Advisory Council. Young people aged 12 year to 24 years who are residents of Lake Macquarie are welcome to submit an application of membership to become a member of the youth council. For more information contact Tony Ellitt on 4921 0182 or email: firstname.lastname@example.com.


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Supported by
A discussion with an architectural matchmaker on construction sheds, Hudson Yards' machismo, and what to do when you've chosen the wrong celebrity architect.
By Ginia Bellafante
Hong Kong Airport, the site of two straight days of protests, is more than just a transit hub. It's at the center of the city's identity.
By Gillian Wong and Megan Specia
The Modernist master left his mark on generations, from Renzo Piano and Norman Foster to David Adjaye and Billie Tsien.
By James S. Russell
The French city has some of the most pristine ancient architecture in Europe — and newer signs of life as well.
By Alexander Lobrano
The British architect Norman Foster's studio has announced plans to raise a skyscraper shaped like an unopened blossom atop a concrete stalk in the city's financial district.
By Palko Karasz
The president-elect will halt construction of a $13 billion airport that is already under construction, prompting protests from the business community and investors.
By Elisabeth Malkin
The city's priciest sale last month was a penthouse occupying the entire 20th floor of the Norman Foster-designed condo at 551 West 21st Street.
By Vivian Marino
Since construction has not yet begun on the Zayed National Museum, the British Museum's loan of valuable artifacts is unlikely to take place.
By Roslyn Sulcas
Mr. Foster, in a joint project with Carlos Rubio Carvajal, will renovate the Hall of Realms, to give the Prado about 17 percent more exhibition space.
By Raphael Minder
As big-name architects create airports with ambitious goals in mind, it's the smaller things — like comfy seating and adequate heating — that are missing.
By Chris Holbrook


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My name is Vivek Sharma and I'm a Technical Recruiter at First Tek. We are currently sourcing for an excellent opportunity for Java Developer in McLean, VA. If you are interested for this opportunity, please revert me with your updated resume.
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From the beginning, I've always wanted to make my own invitations, Save the Dates, everything. I figured I'd start small and make some "Will you be my Bridesmaid" cards. I think they turned out pretty cute. Here's how I did it:
I went to Archiver's and picked out some pre-made cards. I got dark blue circles, white flower shaped circles and white envelopes. I also picked out a pretty flower stamp and some red ink.
First I started experimenting with fonts on my computer until I found one I liked. Once I found one, I printed "Will you be my bridesmaid" in blue on the white scalloped edged circle. This part was a bit challenging as my printer was being bratty and didn't want to take the paper in straight.
Next I glued those to the larger blue circle. After that I took the flower stamp and added that to the bottom corner of the front. I also used it on the back of the envelopes after I sealed them. I had some issues with the stamp smudging. I think I probably need to give them more time to dry before going on to the next step.
They still needed something so I added a small red bow using some ribbon I already had.
I then glued regular white computer paper on the back of the blue circle and wrote a personal note to each of my three bridesmaids. I hope they love them. I think they turned out cute!


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