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Things I have learned - Part 2
Systems should be silent, unless they have something important to say that requires action on the part of the system administrator. In particular, notifcations (e.,g. e-mails, but potentially other mechanisms) should only be sent if they require action. If the action required is not completely obvious from the direct contents of the notification, then you need to add a link to external documentation detailing what needs to happen (e.g. a "trouble code", or a link to your wiki etc).

subset: commoncrawl


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Here's what you need to get started with Windows Mixed Reality
It'll be a while before headsets are shipping, but now is the perfect time to make sure you have everything you need to be ready for the launch of Windows Mixed Reality.
It'll be a while before headsets are shipping, but now is the perfect time to make sure you have everything you need to be ready for the launch of Windows Mixed Reality.
If you're looking to go wireless for your VR rig, there are about to be lots of options. Here's how to choose the best one.
HP is giving professionals more options for VR in the workplace.
Official support for Windows Mixed Reality headsets and smooth locomotion are both included in the latest update to Doom VFR on Steam.
Want to make the picture a bit sharper in your WMR headset? Here's how to use supersampling.
SteamVR, the platform that encompasses the major VR headsets, has some add-on apps that make it even better. Here are the best available now.
There's a lot of concern surrounding children using VR headsets. Here's what you need to know.
If you've been waiting to get your hands on a Windows Mixed Reality headset, you may want to direct your attention to Amazon.
Thanks to VR, you can bring your desktop with you when you escape the real world.
If you're looking for Steam VR games to play on Windows Mixed Reality, here's how to see which are supported.
Wondering how to launch straight into worlds? How to create or use custom avatars? Check out our tips and tricks!
With Xbox Live support and oodles of charm, this is a great puzzler to play in Windows Mixed Reality.
We've had plenty of time with all three major PC-based VR headsets, and we've come up with three 'fixes' we'd like to see in 2018 to make Windows Mixed Reality a total boss.
How is Windows Mixed Reality doing on SteamVR? Not bad actually.
VRChat is a social app that's been gaining in popularity for some time, no doubt helped by the ability to do pretty much anything within. Sound interesting? This guide will get you up to speed.
With the end of camera and adapter production, the death of Kinect is finally complete. It's time to bid farewell to Kinect, and discuss what's next.
Strap in and get ready to hit the highway to the danger zone: Top Gun is coming to Windows Mixed Reality with VR screenings on December 29.
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Real time streamer controller inputs for audience
Have an option to just be able to see a streamers controller inputs in real time. Would help with learning how streamers pull off difficult moves in games. Thinking rocket league would be great for this. I believe trials HD had a feature similar to this in their replays.
1 vote
Eric Pihlblad shared this idea


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- elliecee
- 5 years ago
Hi ladies!
Has anyone tried renting their bridesmaid dresses from Rent the Runway? I have been in love with a gold sequined dress on the site and was lucky enough to see it in person in their NY location. They just opened a Chicago location and am planning on having my BM's make appointments to try the dress on so we're sure they have the right size. Only one I'm concerned about is my Bridesmaid or Best Man in Texas, no Rent the Runway brick and mortar there :(..
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Skip to Main Content
Movement and capture efficiency of radio-tagged salmonids sampled by electrofishingAuthor(s): Michael K. Young; David A. Schmetterling
Date: 2012
Source: North American Journal of Fisheries Management. 32: 823-831.
Publication Series: Scientific Journal (JRNL)
Station: Rocky Mountain Research Station
View PDF (123.04 KB)
DescriptionElectrofishing-based estimates of fish abundance are common. Most population models assume that samples are drawn froma closed population, but population closure is sometimes difficult to achieve. Consequently, we individually electrofished 103 radio-tagged trout of two species, westslope cutthroat trout Oncorhynchus clarkii lewisi and brook trout Salvelinus fontinalis, in five streams in western Montana to quantify the influence of habitat and fish size on capture efficiency and movement related to electrofishing with unpulsed DC. First-pass capture efficiency was 46% and declined on subsequent passes. No variables were related to capture efficiency, and only the percentage of cobble or larger substrate was related to the probability that uncaptured fish would move during the first electrofishing pass. About 20% of the uncaptured fish did not move, and 95% traveled less than 18 m.We concluded that for these streams, the bias in abundance estimates from disregarding movement would be relatively minor.
Publication Notes
- You may send email to firstname.lastname@example.com to request a hard copy of this publication.
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CitationYoung, Michael K.; Schmetterling, David A. 2012. Movement and capture efficiency of radio-tagged salmonids sampled by electrofishing. North American Journal of Fisheries Management. 32: 823-831.
Keywordselectrofishing, radio-tag, salmonids, westslope cutthroat trout, Oncorhynchus clarkii lewisi, brook trout, Salvelinus fontinalis
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- Alien invasions in aquatic ecosystems: toward an understanding of brook trout invasions and potential impacts on inland cutthroat trout in western North America
- Role of climate and invasive species in structuring trout distributions in the interior Columbia River Basin, USA
- Competition and predation as mechanisms for displacement of greenback cutthroat trout by brook trout
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Bitcoin blockchain format of resume33 comments
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Bare with me as I am new to the
flock tool and I haven't used file descriptors as far as I know.
I have a bash script that makes a cURL request and writes the output to a file called
resp.txt. I need to create an exclusive lock so that I can write to that file and not worry about multiple users running the script and editing the text file at the same time.
Here is the code that I expect to lock the file, perform the request, and write to the text file:
flock -e 200
curl 'someurl' -H 'someHeader' > resp.txt
) 200>/home/user/ITS/resp.txt
Is this the correct way to go about this? My actual script is a bit longer than this, but it seems to break when I add the
flock syntax to the bash script.
If someone could explain how these file descriptors work and let me know if I am locking the file correctly that would be awesome!


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Active Highs run wakeboarding and waterskiing in Scotland on a very sheltered loch in the Great Glen. For guests of The Great Glen Water park, as well as anyone who is in the area looking for some great activities to do for a day, weekend or week. During the summer months, Active Highs use a V8... (Wakeboard Highland)
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Results for Favourite Worst Nightmare
The Arctic Monkeys Whatever People Say I Am, That's What I'm Not
The Arctic Monkeys is one of the biggest success stories of recent years. The English group's debut album Whatever People Say I Am, That's What I'm Not, was the fastest selling album in U.K. history. Their U.S. sales were not as strong, but people were still anxious to hear what the group would do for its sophomore act. In fact, they face the same scrutiny that hot debut bands like Franz Ferdinand and The Strokes had to overcome. Neither Jim nor Greg think that their new album, Favourite Worst Nightmare, will be any more successful stateside than the last, but both urge listeners to give it a listen. Greg compares lead singer and chief songwriter Alex Turner to some of the best British wits including Ray Davies and Damon Albarn, and likens his songs to short stories. Jim agrees, calling Turner an astute social critic. The Arctic Monkeys may not be the phenomenon it once was, but Favourite Worst Nightmare gets two Buy Its.
The Best of 2007… So Far
Jim and Greg just couldn't wait until the end of the year to start picking their favorite albums, so they've decided to name their 2007 mid-year best.Go to episode 81


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Yet another potential franchise quarterback for the Cleveland Browns is no longer available as Adam Schefter of ESPN is reporting the New England Patriots have traded backup quarterback Jimmy Garoppolo to the San Francisco 49ers.
The talk all day has been about how badly the Cleveland Browns whiffed on not drafting two stud quarterbacks that both fell into their lap. Those two quarterbacks being Deshaun Watson (Houston) and Carson Wentz (Philadelphia) who have both been impressive since coming into the league. Wentz in 2016 and Watson in 2017.
The pair of young signal callers have been arguably the most consistent and effective quarterbacks in the NFL thus far this season. The Browns front office is under a lot of heat for passing them up. Now, things have gotten even worse for those who were holding out hope that the Browns would find a way to use one of their 5 picks in the first 60 next season (2 first round, 3 second round) to trade for New England's Jimmy Garoppolo.
The backup to Tom Brady has now been dealt to the other winless franchise, the San Francisco 49ers for a second round pick in the 2018 NFL Draft. To think the Browns could have had him by giving up one of their own 3 second round picks, and passed on it, is simply inexcusable, but what we've come to expect from this front office.
In three starts last season for the suspended Tom Brady, Garoppolo shined. He tossed 4 touchdowns with 0 interceptions while completing 68.3 percent of his passes. Far better numbers then any Cleveland Browns quarterback during any 3 game stretch the past two seasons. To make room for Garoppolo, the 49ers will be releasing former Browns quarterback Brian Hoyer.
The beat rolls on……


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It's Complicated
Created on Sunday, 20 July 2008 00:00
Written by Elaine
It's Complicated, directed by Nancy Meyers (Something's Gotta Give, The Holiday), is an example of an average romantic comedy made successful with a charming cast.
Meryl Streep plays Jane Adler, successful owner of a bakery and mother of three grown-up children, and Alec Baldwin plays Jake, her attorney ex-husband due to a one-time infidelity. Noteworthy in the rest of the cast are son-in-law John Krasinski (The Office) and love interest Steve Martin (Pink Panther).
So why exactly is it complicated? When Jane and Jake - divorced for a decade - heads down to New York for their son's college graduation, they get involved in a one-night-stand. Jake, who is re-married to the woman he committed infidelity with, sweet talks Jane into continuing the affair and ironically becoming the other woman upon their return. And as in all romantic comedies, the female lead is pursued by another - architect-turned-love interest Adam (Steve Martin) - who adds on to Jane's complicated over-aged love life.
The veteran cast, especially Streep, plays an important part in this movie. Had the actors not been as lovable, the romantic comedy would've fallen flat. The audience will be more likely to remember the actors' acting rather than the plot. Their acting clearly reflected their experience though they were all a little much in their own ways - Streep was a little too giggly, Baldwin too naughty and Martin was way too shy.
It's Complicated is the kind of romantic comedy that film-goers could count on for an enjoyable but forgettable time, and especially uplifting for older women. Think older woman with three grown-up kids pursued once again by ex-husband and another man at the same time. It is also the kind of average film you will not recommend to your friends on your own accord but neither will you deny that it brought you a few laughs and a pretty decent way to spend - a slightly too long - two hours.
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I was very happy with the hygiene and quality of my treatment. I had more work done than I was anticipating, but their equipment was great, and they explained why the treatment was worthwhile ...
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Treatment received: Crowns
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Treatment received: Tooth extraction, bone grafting, implant and porcelain crowns.
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Treatment received: Crowns - Treatment date: 11/10/2019
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Treatment received: Wisdom tooth extraction
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Frequently answered questions
All-on-4 is an immediate dental restoration option for patients with total tooth loss on both jaws. The restoration is placed on 4 implants. A whole All-on-4 procedure from A to Z may take from 2 to 3 days.Details
Listen to the answer given by implant experts from The East Rose Dental (Old Rose Dental Clinic).Details
Dental crowns are a method used to offer cosmetic improvements in dental flaws. However, if you are still confused, not knowing if your condition calls for porcelain crowns or not, it's best to visit a dental clinic. We don't know how much your teeth are damaged, whether there is any misalignment or unevenness or not. To give you accurate advice, dentists will have to see your teeth in person.Details
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text: On Sun, Jun 12, 2011 at 20:38, Arthur Reutenauer wrote: > Hi Daniel, > >> I am trying to make myself clear: I would like to know if it wouldn't be possible to employ a custom >> Unicode hyphenation rules/pattern file also for Pdflatex/Babel when the text there is Unicode, too As Arthur pointed out, you cannot simply load hyph-foo.tex file with UTF-8 patterns without loading other macros to handle UTF-8 *before* patterns themselves. (You may try and see what happens.) But we tried to make sure that all patterns that can reasonably work in pdfTeX do work. Indic languages, Sanskrit, "Ethiopic", Lao etc. were disabled in pdfTeX because we had no idea how to handle them. > However, I'm going to venture a wild guess and assume that the language you're interested in is Sanskrit, a language which actually has patterns disabled for pdfTeX, because we couldn't determine what font encoding was appropriate when the patterns were submitted: for the vast majority of languages that had patterns when Mojca and I took over work on hyphenation files three years ago, there was one single 8-bit encoding, that was used by both the pattern file and the Babel support files. Several languages, though, have been added in the mean time, including Sanskrit, that had no dedicated 8-bit encoding that we could use(*). We thus decided to make them available for Unicode-aware TeX engines only; hence, you don't have access to them from pdfTeX. But if you have a reason to want to use them, we'll gladly make them available as well. That won't be a problem at all; we only never considered the issue because we didn't think it would come up -- Mojca, what do you think? I would really like to know what language Daniel is referring to before any further discussion. If it is really about Sanskrit ... I have no idea how one can type it in UTF-8 in pdfTeX. All the examples about Devanagari that I found were using ASCII and were pointing to Velthuis' package claiming: % Hyphenation % ~~~~~~~~~~~ % The responsibility for hyphenating Devanagari text is taken over % completely by the preprocessor, devnag.c. The preprocessor inserts % discretionary hyphenation points (\-) in all the places it thinks are % appropriate. or whatever other older package. I would need more input to provide any reasonable answer. Mojca


text:
A billboard with a picture of Pope Tawadros II welcoming Pope Francis, at St. Mark's Cathedral in Cairo.
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Pope Francis is facing a religious and diplomatic balancing act as he heads to Egypt this weekend, hoping to comfort its Christian community after a spate of Islamic attacks while seeking to improve relations with Egypt's Muslim leaders.The visit, though, marks a diplomatic breakthrough for Rome after Al-Azhar severed relations with the Vatican in 2011 after Pope Benedict XVI demanded Egypt better protect its Christian minority following a New Year's Eve church bombing that killed more than 20 people.Francis has spent the better part of his four-year papacy seeking to mend the ties, and last year hosted Tayeb at the Vatican. For Tayeb, then, the pope's visit is a timely godsend, showing him as a promoter of Christian-Muslim dialogue who not only scored a visit by Francis, leader of the world's 1.2 billion Catholics, but also Patriarch Bartholomew I, the spiritual leader of the world's Orthodox Christians.That said, even some of Francis' own Jesuit confreres caution that the pope is naive in trying to hold dialogue with Al-Azhar and an Islamic tradition that they say remains stuck in the Middle Ages.


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South Island Explorer
New Zealand
9 Days
Activity Level
Comfort Level
Our South Island Explorer is for travelers who want to go deep into a variety of environments in the company of a seasoned, brilliantly informed guide. The accommodations are small and magnificently sited and are reserved by our operator two years in advance. Each day brings new activities, new vistas, and new experiences. Evenings bring good food and warm conversation that inevitably heighten understanding of the region and its people. You'll find your hosts to be open, good-spirited, and deservedly proud of their precious birthright, New Zealand.
On this South Island adventure, you will first explore Christchurch and witness the spectacular scenery of Arthur's Pass and Fox Glacier. Next, take in the sights of Lake Moeraki, experience the natural beauty of the surrounding rain forests, and observe the flora and fauna of the area. From here, you will pass by glacial lakes on your way to Queenstown, where you will have a full day to enjoy any number of activities from hiking to shopping. Finally, you will visit Milford Sound, an absolutely breathtaking section of Fiordland National Park, filled with glaciated valleys, lush rain forests, and stunning alpine views.
Great For
- Natural Beauty
- Hiking
- Photography
- Reflection
Day 1 Christchurch
Upon arrival in Christchurch, you will be met by your guide and and driven through the "Garden City" and up onto the Port Hills, the flanks of one of the ancient extinct volcanoes that form the Banks Peninsula. From the hills, there are spectacular views of the city and the Kaikoura Range can be seen far to the north, while the Pacific Ocean sparkles to the east. To the south and west, the vast Canterbury Plains stretch to the horizon and in the distance, the Southern Alps beckon you to discover them.
Having orientated yourselves in Christchurch, you will then escape the city and start your journey west across the Canterbury Plains. As the distant mountains become closer, you may wonder, just like the Maori and the early settlers before us how you will find a way through. Crossing Porter's Pass, a dramatic landscape change occurs as you enter the high country, a high tussock grass basin bounded by the Torlesse Mountains to the east and the Craigieburn Mountains to the west.
Traveling through this region you will pass glacial formed lakes and the limestone formations of Castle Hill which dominate the landscape. Farther on, you will reach the wide expanse of the Waimakariri River and the Wilderness Lodge Arthur's Pass.
Afternoon Tea, Dinner
Afternoon Tea, Dinner
Day 2 Arthur's Pass
This is a day where you can explore and discover the alpine plants and animals of Arthur's Pass, and take in the spectacular Southern Alps. Experience the workings of a high country sheep farm and help with the day-to-day activities such as feeding out, mustering, or working with the dogs. Walking, canoeing and mountain bike riding are activities available at the lodge, or, if you prefer, just relax and enjoy the views of the Southern Alps.
Breakfast, Morning Tea, Lunch, Afternoon Tea, Dinner
Wilderness Lodge Arthur's Pass
Day 3 Arthur's Pass/Hokitika/Fox Glacier
After breakfast, cross the pass that was once used as a gold rush link and by the Maori in their search for greenstone, and travels through Arthur's Pass National Park, home of the kea, the world's only alpine parrot. Continue down the spectacular Otira Gorge, follow the rivers to the West Coast, and walk an old gold miner's trail. Visit Hokitika, once a very large gold mining town, and walk through an ancient coastal forest. At the Bushman's Centre, meet a "Coaster" and some of the locals. Heading further south, see the west coast bush and the kettle lakes that were created by the melting ice sheets at the end of the last Ice Age. Then, travel to Fox Glacier – a truly incredible sight! Stay overnight at Te Weheka Lodge.
Breakfast, Morning Tea, Afternoon Tea
Franz Josef or Fox Glacier or similar
Day 4 Fox Glacier/Lake Moeraki
Today you will explore the glaciated landscape of the Fox Glacier region, where you can take a hike up to the ice with an experienced alpine guide. For those who would like something a little more passive, enjoy a walk to a glacier viewpoint or take an optional helicopter ride to view the Southern Alps, with a special landing on the upper reaches of the glacier. After lunch, you can take a beautiful and tranquil walk to Lake Matheson, where incredible reflections of Mount Cook and Mount Tasman can often be seen. From Fox Glacier, journey farther south to Lake Moeraki, an area of pristine rainforest and spectacular coastline. This is the breeding place of the rare Fjordland Crested penguin (seasonal) and also hosts a seal colony, Hector's dolphins, and numerous native birds. Stay overnight at the Lake Moeraki Wilderness Lodge, a Tourism Award Winner.
Breakfast, Morning Tea, Lunch, Afternoon Tea, Dinner
Lake Moeraki Wilderness Lodge
Day 5 Lake Moeraki
Your day will be spent at Lake Moeraki, a nature lover's paradise. Here, you will experience spectacular beaches that are home to fur seals and crested penguins and see untouched lowland rainforests. These rainforests are interspersed among pristine lakes and rivers, which drain the snow-capped Southern Alps. Activities include guided walks to get close to the wildlife, to learn about the forest, and to experience the amazing scenery. If you prefer to have a restful day, then you can take a canoe out on the tranquil lake or just relax in the lodge.
Breakfast, Morning Tea, Lunch, Afternoon Tea, Dinner
Lake Moeraki Wilderness Lodge
Day 6 Wanaka/Arrowtown/Queenstown
Depart for Wanaka crossing over the Haast Pass where you will notice the land changing dramatically as the road climbs from the dense rainforest of the West Coast to the drier tussock lands of Otago. Pass Lakes Hawea and Wanaka, ancient glacial lakes, before heading over the rugged and remote Crown Range, the sight of gold diggers in the 1860s then on to Arrowtown. Visit the old Chinese gold miners' settlement and view this quaint old miner's village. Afterwards, continue on to Queenstown where you overnight at the Millbrook Country Resort for the next three nights.
Breakfast, Morning Tea, Afternoon Tea
Millbrook Country Resort or similar
Day 7 Queenstown
You will have a free day to experience some of the many optional activities that Queenstown has to offer. Enjoy a relaxing cruise on the old steamship Earnslaw, the lady of the lake, or perhaps try an exhilarating jetboat trip through the Shotover Canyon. Shopping, staking in the spectacular views from the gondola, bush walks, or an arts and crafts trail are just of the few things you can do here. For those who wish to hike, a climb up Queenstown Hill offers spectacular views. Your guide will be available to assist with transfers as required.
Millbrook Country Resort or similar
Day 8 Milford Sound Excursion
The road to Milford Sound through the Fjordland National Park is absolutely breathtaking with its sheer U-shaped glaciated valleys, waterfalls, and lush, temperate rainforests. The Homer Tunnel, entry to the Cleddau Valley and Milford Sound, is a tribute to the engineers' skills in the 1930s. Explore the fjord on a cruise through deeply carved glacial valleys, past ancient forests and incredible rock formations before heading back to Queenstown. Catch a glimpse of the extremely rare Takahe, a flightless bird, at a sanctuary in Te Anau, and take a short walk to see waterfalls, alpine views, and lakes. Optional alternatives include a helicopter trip which can include a snow landing or perhaps a return to Queenstown by scenic flight (not included in tour cost).
Breakfast, Morning Tea, Lunch, Afternoon Tea
Millbrook Country Resort or similar
Day 9 Queenstown/Onward
After breakfast, you will have time for some last-minute shopping or to experience that last piece of adventure before you bid farewell to New Zealand.
Dates & Price
Best Time of Year to Visit
Our South Island Explorer is for travelers who want to go deep into a variety of environments in the company of a seasoned, brilliantly informed guide. The accommodations are small and magnificently sited and are reserved by our operator two years in advance. Each day brings new activities, new vistas, and new experiences. Evenings bring good food and warm conversation that inevitably heighten understanding of the region and its people. You'll find your hosts to be open, good-spirited, and deservedly proud of their precious birthright, New Zealand.
On this South Island adventure, you will first explore Christchurch and witness the spectacular scenery of Arthur's Pass and Fox Glacier. Next, take in the sights of Lake Moeraki, experience the natural beauty of the surrounding rain forests, and observe the flora and fauna of the area. From here, you will pass by glacial lakes on your way to Queenstown, where you will have a full day to enjoy any number of activities from hiking to shopping. Finally, you will visit Milford Sound, an absolutely breathtaking section of Fiordland National Park, filled with glaciated valleys, lush rain forests, and stunning alpine views.
Rates Per Person
Need to Know
Rates Per Person - 2019
Land Cost
Single Supplement
+ $1,385
Rates Per Person - 2019
The cost quoted is the Land Cost and is subject to change. This covers accommodations, transfers, activities, touring, guide services and meals as described in Journeys' Trip Notes. The quoted Land Cost will apply when group size falls in the specified range and when travel is on the indicated dates.
Need to Know
PLEASE NOTE: Prices may fluctuate based on the exchange rate between the U.S. Dollar and the New Zealand Dollar.
Expenses covered
Normally, our stated land costs include the cost of all guides, leaders, permits obtained after arrival, lodging accommodations, food and entry fees as specified, and all surface transportation associated with the planned itinerary. We do our best to avoid increasing prices after receipt of your deposit, but, rarely, factors beyond our control might require us to change our prices without prior notice, even after you have signed up.
Expenses not covered
Costs not included in the price may include: meals not indicated as included in itineraries; meals prior to arrival in starting cities; transfers, if not arriving or departing on the scheduled group flights; soft drinks, bottled water, and alcoholic beverages; medical expenses, costs of hospitalization, or evacuation from remote areas; laundry; airport departure taxes not included on your airline ticket; accommodations en route to starting cities; visas; airfares; gratuities; and insurance.
Payment and Deposit Schedule
Please note: Prices on this trip may fluctuate based on the exchange rate between the US Dollar and the New Zealand Dollar. Deposit schedule: A 20% per person per trip or the applicable amount based on the trip and the proximity of the departure date. A second deposit of $1,000 per person is due four months prior to departure, and final payment for land arrangements is due 60 days prior to departure. Airlines require full payment when tickets are issued. The deposit may be made by Visa, Master Card or check, and the Reservation Form may be submitted via our website. Full payment schedule and cancellation penalties are described in our Terms and Conditions as noted on our website and elsewhere. Please request these if you do not have them before advancing a deposit.
We can help you secure air travel arrangements to correspond with land travel booked through Journeys International. We work with an airfare consolidator to assist in booking the flights that suit your needs. If you decide to make your own flight arrangements, you must provide Journeys International with a complete copy of your itinerary showing departure and arrival flights and times. You should plan to arrange your own air travel if you are using mileage credit or originating outside North America, but please be in touch with our office before you finalize ticketing so that we can help you to coordinate the correct arrival and departure dates and times.
When you make your reservation, we strongly recommend the purchase of comprehensive travel insurance in case of emergency situations. Please contact us for a recommended policy.
Itinerary Change Fee
There will be a $40 fee for changes once an itinerary has been confirmed and approved. Additional cancellation penalties or change fees may apply as per our terms and conditions. The passenger is responsible for such fees.
Duration 9 Days
The number of days, or duration, in a destination corresponds with the itinerary as published. This is the time period covered by the land cost.
Group Size 4 - 6
The stated range indicates minimum required for guaranteed departure and maximum accepted on the scheduled dates. Exceptions can often be made for private departures.
Comfort Level
deluxe wilderness lodges
Activity Level
Activity Level
Match the trip's intensity to your ability and motivation.
Easy walking, with opportunities for low-key physical activity.
Energetic exploration with optional day hikes, leisurely cycling, or light canoeing.
Day-long active excursions and options for demanding activity in varied environments.
Strenuous hiking or other intense activity that may be at high altitude or over rough terrain.
Multi-day trekking and other activities requiring endurance or strength. Steep trails. No technical expertise necessary.
Comfort Level
Choose accommodations and amenities that fit your personal style
Our most natural accommodations. Bath facilities often shared, sometimes rustic.
Comfortable and especially personal. Small to mid-sized lodges, typically with private bath.
Lodges and hotels with additional amenities, refined artistry, or extra-special settings.
Exclusive or luxury lodges, hotels, or safari camps with fine dining options.
The most indulgent accommodations arranged specially for private trips.


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text: Background House dirt mite (HDM) allergens are a major cause of allergic asthma. fluid collected following allergen challenge was also assessed for the presence of HDM-specific antibodies. To examine the cellular immune response to HDM allergens, T cell (-)-Gallocatechin gallate irreversible inhibition proliferation and cutaneous responses were assessed in sensitized and control sheep. Results Strong HDM- and Der p 1-specific IgE, IgG1, IgG2 and IgA serum responses were observed in sensitized sheep, while detectable levels of HDM-specific IgG1 and IgA were seen in BAL fluid of allergen-challenged lungs. In contrast, minimal antibody reactivity was observed to Der p 2. Marked T cell proliferation and late phase cutaneous responses, accompanied by the recruitment of eosinophils, indicates the induction of a cellular and delayed-type hypersensitivity (DTH) type II response by HDM and Der p 1 allergen, but not Der p 2. Conclusion This work characterizes the humoral and cellular immune effects of HDM extract and its major constituent allergens in sheep sensitized to HDM. The effects of allergen in HDM-sensitized sheep were detectable both locally (-)-Gallocatechin gallate irreversible inhibition and systemically, and probably mediated via enzymatic and immune actions of (-)-Gallocatechin gallate irreversible inhibition the major HDM allergen Der p 1. This study extends our understanding of the actions of this important allergen relevant to human allergic asthma and its effects in sheep experimentally sensitized to HDM allergens. Background Many proteins of the house dirt mite (HDM) em Dermatophagoides pteronyssinus /em are powerful enzymes and stand for the main things that trigger allergies associated with individual allergic asthma [1]. One of the most thoroughly researched HDM things that trigger allergies are Der p 1 and Der p 2 and it's been shown that most HDM-sensitized asthmatic sufferers (80a100%) possess solid serum IgE replies to these things that trigger allergies [2]. The direct and immunological biological ramifications of HDM allergens have already been well documented lately. Regional and systemic immune system ramifications of HDM things that trigger allergies consist of activation and recruitment of immune system cells, discharge of inflammatory mediators as well as the up-regulation of pro-inflammatory adhesion substances [3-5]. Der p 1, one of the most immunodominant and researched HDM allergen broadly, is certainly a cysteine protease with reported immune system and enzymatic results in hypersensitive individual asthma [1]. Der p 1 proteolytic activity is certainly regarded as a significant contributor to its allergenicity. A number of the reported activities of Der p 1 consist of direct immunomodulatory results through cleavage/down-regulation of Compact disc23 on B cells [6], Compact disc25 on T cells [7] and Compact disc40 on dendritic cells [8], aswell as the disruption of restricted junctions in the bronchial epithelium resulting in elevated cell permeability [9]. Many studies using pet models of hypersensitive asthma possess used rodents and so are predicated on sensitization and task using the 'un-natural' allergen ovalbumin. With mounting proof for the powerful function of HDM things that trigger allergies in shaping immune system replies in the tissues microenvironment, there's a need for even more animal versions that make use of the HDM things that trigger allergies COL12A1 as a far more relevant model for the individual disease [1,10]. The introduction of em in vivo /em pet types of experimental asthma (-)-Gallocatechin gallate irreversible inhibition predicated on HDM things that trigger allergies has raised additional interest in discovering the specific jobs that natural things that trigger allergies play in hypersensitive disease. HDM results have been looked into in small pet types of asthma [11-16], while prior studies in our laboratory have reported the effects of HDM in a sheep model of allergic asthma [17-20]. The HDM sheep asthma model displays many of the characteristic features of human allergic asthma including HDM-specific IgE responses, eosinophilia, mucus hypersecretion of the airways, and airway remodeling following chronic allergen exposure. A proportion of HDM allergic sheep also develop increased airway resistance and (-)-Gallocatechin gallate irreversible inhibition airway hyperreactivity similar to human asthmatics [20], validating the suitability of this experimental sheep asthma model. The present.


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The data relating to real estate for sale on this website appears in part through the TREND Internet Data Exchange program, a voluntary cooperative exchange of property listing data between licensed real estate brokerage firms in which Callaway Henderson Sotheby's International Realty participates, and is provided by TREND through a licensing agreement and identified with the TREND IDX Logo. Some properties which appear for sale on this website may no longer be available because they are under contract, have sold or are no longer being offered for sale. Some real estate firms do not participate in IDX and their listings do not appear on this website.Some properties listed with participating firms do not appear on this website at the request of the seller.
2019 TREND, All Rights Reserved. Information Deemed Reliable But Not Guaranteed.
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- Sewer
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