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The move to a digital world has come with many casualties. Rights ownership is largely a thing of the past, as everyone just purchases licenses to content in digital formats now. The advantages include saving a lot of physical space and avoiding a catastrophe like a flood or fire damaging a collection — an all-digital library being destroyed would just result in the hardware needing to be repurchase. While that's an extreme situation, it's also a realistic one. If the digital marketplace goes down, however, then you'd be completely out of luck. If that seems unrealistic, then you need to pay attention to history for those who forget it are doomed to repeat it.
It was only a few years ago when Sony was hacked and PSN as a whole went offline for over a month. This resulted in people being unable to download any content — including games, which made reviewing a bit harder even then and retrieving past purchases impossible. Some games, like Capcom's Final Fight Double Impact, were rendered completely unplayable due to requiring an online check before being played. This crippled the PS3 for a while and Sony lost a lot of goodwill as a result. They regained as much of it as possible with a variety of free games, but the damage was done. You couldn't call the emperor anything else but naked at this point, and Sony did what they could to fix the problem quickly while offering up some free games — like Infamous 2.
Sony was effectively forgiven by the public, who at least also got to use a free year of credit monitoring due to this, and Sony seemingly filled the security holes that led to the attack. Fast forward from then until last month and Sony Pictures is hacked. The upcoming release "The Interview" is believed to be the reason for it, with North Korean hackers being the lead suspects so far due to the fact the movie focuses on taking out Kim Jong-un. The end result of this hack is that Sony Pictures now has a ton of pissed-off people to deal with. Employee e-mails got out and buried stars like Kevin Hart, Angelina Jolie and even their own films. Adam Sandler's films were thrown under the bus and bits like the new James Bond movie "Spectre" being massively over-budget paint a horrible picture for the company. What's worse is that social security numbers got out for not only over 45,000 employees, but celebrities like Conan O'Brien and Sylvester Stallone.
If SCE was hacked and we saw private e-mails made public, gaming journalism as we know it would likely change. There would definitely be some private conversations getting out about certain outlets, resulting in possible blackouts from some places depending on the nature of the release. If something got out with personal attacks on a site's owner and/or staff, then the site could easily go "okay, we've got tons of other companies to cover – we don't need to cover one that disrespects us." One lesson SCE can learn from the Sony Pictures hack scandal is to keep any disparaging comments to verbal conversation only. While there may be a leak of that to some degree, at least that would keep things contained to just a few conversations at most and not expose everything. If a third-party deal was signed (like for a console-game tie-in) and SCE complained internally about the terms, it could have disastrous results for them.
Most importantly, a hack could easily burn bridges with third party publishers. SCE's credibility would be killed and with the PlayStation brand being one of the few bright spots for Sony, it could actually kill the parent company. Would it continue in some form? Sure — some company would buy the rights to the name, but it would just exist as a brand. The PlayStation name carries a lot of weight, so it would make sense to keep that alive in some form — even if it was just for a set-top box capable of playing PS1, PS2, PS3, PSP and Vita content.
Sony as a company is in worrisome straits right now – not dire though. The PlayStation brand is their saving grace, and hopefully the Sony Pictures hack leads to them redoubling their efforts with security. Moreover, it should lead to some introspection. If they've got a slew of issues with their stars and the films they make, then it's clear that they need to re-evaluate things for 2015 and consider the longer-term consequences of some releases. They're not happy with Adam Sandler movies, so it would seem like a wise idea to either stop making them or release them under another brand under their umbrella.
Sony Pictures's current strategy seems to be just going as low-profile as possible and not making any more waves. The cast of The Interview wasn't allowed to answer questions, and it seems like they'll be squeaky-clean for a little while when it comes to public statements. SCE would probably take a similar tactic as it's likely a company-wide directive. An SCE hack would have everyone scurrying to just use PSN code cards instead of credit cards, and perhaps lead to a large class action lawsuit — especially if user information was compromised. SCE needs to tread carefully and doesn't appear to have made any public comments about the Sony Pictures hack, which is probably a smart move. There's no need to give a hacking group a reason to come after you and Sony as a whole could dissolve if SCE was hacked. It would take some time, sure, but that would be the eventual result. The gaming industry needs competition and Sony has raised the bar a ton over the past decade. Losing them would set things back, and that wouldn't benefit anyone.


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These Are the Biggest Money-Makers for UK Politicians
While British MPs are in line for yet another substantial pay rise this year, that isn't enough to keep most of them satisfied. Effective from 1 April, your MP will be getting a 1.8% pay rise, equivalent to an average annual salary increase of £2,089 according to The BBC. While most of us can only…
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Abstract: A collection of folklore and local history stories from Gort an Tuair (school) (Gortatoor, Co. Mayo), collected as part of the Schools' Folklore Scheme, 1937-1938 under the supervision of teacher Áine Nic Oirealla.
Original reference: 0141/5
Original reference: 0141/5
Gort an Tuair is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of the original resource: University College Dublin
To use for commercial purposes, please contact the National Folklore Collection, UCD - See: http://n2t.net/ark:/87925/h1cc0xm5


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49 Above: Guelph's Elaquent – Producer Extraordinaire
Onwards to beautiful Guelph, Ontario! Guelph is a mid-sized university town in Southern Ontario, close enough to Toronto for an easy day trip, but far enough away from the bustle to be its own thing. Like Kitchener, London, and other Southern Ontario towns, Guelph has a massive arts and cultural scene that is often overshadowed by the big TO looming nearby. […]Read more ›


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Tag Archives: Page of Cups
Reading for week of April 14-20, 2019.
"The cycles and seasons come in their own time and for their own purpose, and I will be patient and vigilant because I trust that knowledge and wisdom will be revealed to me at the time that it is intended … Continue reading
Posted in Soul-Full Sunday's, Tarot Musings-Home Tagged Anna Klaffinger, Anna.K Tarot, High Priestess, King of Pentacles, Knight of Pentacles, Page of Cups Comments Off on Reading for week of April 14-20, 2019.
Reading March 10, 2015
Reading for Tuesday, March 10, 2015 is from the Steele Wizard Tarot by Pamela Steele – 2006. Page of Cups – Six of Cups – Ten of Cups "For Equilibrium, a Blessing: Like the joy of the sea coming home … Continue reading
Posted in Daily Draws Tagged Page of Cups, Pamela Steele, Six of Cups, Steele Wizard Tarot, Ten of Cups Comments Off on Reading March 10, 2015
Cotd Monday, February 9, 2015
The cotd for Monday, February 9, 2015 is from the Anna.K Tarot, (second edition), by Anna Klaffinger. Page of Cups "The Page of Cups asks us to cultivate a certain mental attitude, or to inwardly prepare for certain ways of … Continue reading
Posted in Daily Draws Tagged Anna.K Tarot, Page of Cups, Reconciliation 1 Comment
Cotd January 20, 2015
The Cotd for Tuesday, January 20, 2015 is from the Tarot of the Hidden Realm by Julia Jeffrey, companion book Journey into the Hidden Realm by Barbara Moore. 2013 Page of Cups "This card represents someone who is fascinated by … Continue reading
Posted in Daily Draws Tagged Barbara Moore, Julia Jeffrey, Llewellyn Publications, Page of Cups, Tarot of the Hidden Realm Comments Off on Cotd January 20, 2015


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Molecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting.
AuthorsWest, Catharine M L
McKay, Michael J
Hölscher, Tobias
Baumann, Michael
Stratford, Ian J
Bristow, Robert G
Iwakawa, Mayumi
Imai, Takashi
Zingde, Surekha M
Anscher, Mitchell S
Bourhis, Jean
Begg, Adrian C
Haustermans, Karin
Bentzen, Soren M
Hendry, Jolyon H
AffiliationAcademic Department of Radiation Oncology, The University of Manchester, Christie Hospital NHS Trust, Withington, Manchester, UK.
Issue Date2005-08-01
MetadataShow full item record
AbstractPURPOSE: There is increasing interest in radiogenomics and the characterization of molecular profiles that predict normal tissue and tumor radioresponse. A meeting in Amsterdam was organized by the International Atomic Energy Agency to discuss this topic on an international basis. METHODS AND MATERIALS: This report is not completely exhaustive, but highlights some of the ongoing studies and new initiatives being carried out worldwide in the banking of tumor and normal tissue samples underpinning the development of molecular marker profiles for predicting patient response to radiotherapy. It is generally considered that these profiles will more accurately define individual or group radiosensitivities compared with the nondefinitive findings from the previous era of cellular-based techniques. However, so far there are only a few robust reports of molecular markers predicting normal tissue or tumor response. RESULTS: Many centers in different countries have initiated tissue and tumor banks to store samples from clinical trials for future molecular profiling analysis, to identify profiles that predict for radiotherapy response. The European Society for Therapeutic Radiology and Oncology GENEtic pathways for the Prediction of the effects of Irradiation (GENEPI) project, to store, document, and analyze sample characteristics vs. response, is the most comprehensive in this regard. CONCLUSIONS: The next 5-10 years are likely to see the results of these and other correlative studies, and promising associations of profiles with response should be validated in larger definitive trials.
CitationMolecular markers predicting radiotherapy response: report and recommendations from an International Atomic Energy Agency technical meeting. 2005, 62 (5):1264-73 Int. J. Radiat. Oncol. Biol. Phys.
JournalInternational Journal of Radiation Oncology, Biology, Physics
PubMed ID16029781
Scopus Count
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- Authors: Chen Y, Trotti A, Coleman CN, Machtay M, Mirimanoff RO, Hay J, O'brien PC, El-Gueddari B, Salvajoli JV, Jeremic B
- Issue date: 2006 Apr 1
- First report on the patient database for the identification of the genetic pathways involved in patients over-reacting to radiotherapy: GENEPI-II.
- Authors: De Ruysscher D, Severin D, Barnes E, Baumann M, Bristow R, Grégoire V, Hölscher T, Veninga T, Polański A, van Veen EB, Verfaillie C, Heeren G, Damaraju S, Just U, Haustermans K
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Re: Consumed by resentments...out of the rooms
Posted: Thu Sep 13, 2018 4:46 am
True. But as part of the 12th step, we are to carry the message to people who are still suffering. Of course there are other avenues like institutions and treatment facilities. Hope you find some options.Thankfully that is not the case.


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The 37 Miles of Smiles Convoy visits IUG with generous support for students and the university.
A decent delegation from the Miles of Smiles Convoy has managed to reach the Islamic University this day with a strong determination to support Gaza people, break the siege and well stand by the IUG students and IUG Irada persons with disabilities.
Praising the Islamic University role in serving the education, the president of the convoy Dr. Essam Youssef showed his ceaseless support to IUG during meeting with IUG president and professors at the IUG VIP Hall this morning 13 July 2019: "We are working on empowering the students for continuing their study and find a suitable job after graduation", Dr. Youusef added, " This is my call for our delegation members to take the students' issues in their consideration".
The decent delegation has included the president of the convoy Dr. Essam Youssef-from Britain- accompanied with his deputy Khaled Youssef-from Sweden- as well as Mr. Abdullah Al-Sultan-from Kuwait- in addition to Muhsinat group from Jordan: the president Em Anas and her deputy Em Tareq.
When she was asked about her mission for accompanying the Convoy, the president of Muhsinat group from Jordan Em Anas assured " This visit resulted in funding 18 medical students and other 68 students whom their graduation certificates are suspended in addition to launching the olive trees' project at IUG,"
The visiting delegation has been impressed by the topnotch training programs which launched at Irada center and dedicated for persons with disabilities with a view to making them integrated into the society. "For IUG persons with disabilities, we have adopted equipping a training workshop for cars' maintenance" Em Tarq added.


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JAMESTOWN, Tenn. (WVLT) — The Jamestown Regional Medical Center announced plans to cut about 20 jobs.
According to a release from Rennova Health, the hospital's parent company, the hospital has always tried to have more staff on hand than was necessary, and the hospital "has sustained a significant decline in recipient of payments over recent months, caused in part by mistakes made at the facility during a transition to a new billing company in December 2018."
The release said those mistakes have been corrected and the company expects to receive what it's owed, there are other problems that the hospital is facing. Recently the Centers of Medicaid and Medicare Services announced that Jamestown Regional Medical would no longer receive Medicaid and Medicare reimbursements.
The hospital


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In the 57th minute, Onyango had to show his class, plunging to his left to brilliantly keep out a header from Chippa striker Rhulani Manzini.
That was Manzini's last contribution as he was replaced not long after by new Chippa signing Tercious Malepe.
Vilakazi then wasted a glorious opportunity to score as he displayed perfect control inside the penalty area, but with only Tignyemb to beat, put his close-range effort over the bar.
And Sundowns were left to rue that miss in particular as Chippa struck late to grab a point.
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Dimensions:W: 25" (63.5 cm)H: 14" (35.6 cm)
I love the weave in this Shui minority homespun cotton. It has a wonderful thick textured appearance and the pattern is a tiny grid enclosing small diamonds.
This weave is in natural cotton and indigo and I've added a thick natural cotton fringe. It has a zip fastener and feather pad.
There is one in this size and a pair listed separately that are 14" x 18".
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Assistant Nurse Manager
University of California Davis
Assistant Nurse Manager
University of California Davis
October 18, 2019
Sacramento, California
Assistant Nurse Manager
Department Description
Emergency Medicine provide Level 1 adult and pediatric trauma care for more than 33 of California's 58 counties. UC Davis Health System is home to state-of-the-art emergency care for children. Our Pediatric Emergency Department features the only Level 1 pediatric trauma center in inland Northern California (verified by the American College of Surgeons). From Portland to Fresno, from outside the Bay Area to Reno, no other hospital in inland Northern California has a Level 1 adult and pediatric trauma center servicing approximately 70,000 patients each year.
The Department of Emergency Medicine at UC Davis provides a dedicated team of physicians, nurses, 42 residents, and a total of 26 specialists of every medical and surgical specialty to treat critically ill and injured adults and children. Our team provides an extraordinary level of knowledge, skill and compassion to every patient we serve at our Level 1 Surgery and Emergency Services Pavilion. The Emergency Department is prepared and equipped to provide comprehensive and efficient emergency care to patients in need of medical and surgical specialty physicians to treat critical and acute illnesses and injuries 24 hours a day, 365 days a year.
Job Summary
Salary Range : $40.71/hr. to $97.03/hr.Salary Frequency : Hourly Appointment Type : CareerPercentage of Time : 100%Shift Hour : 7:00 PM - 7:00 AMLocation : Surgery & Emergency Serv PAVCity : SacramentoUnion Representation : NoBenefits Eligible : Yes We offer exceptional employment benefits including medical, dental, and vision plans, generous paid vacations and holidays, excellent retirement savings and investment plans, continuing education, and reduced fee and scholarship programs. THIS IS NOT AN H1- B OPPORTUNITY ResponsibilitiesAssistant Nurse Managers are registered nurses who are responsible for the operation of the nursing unit over a specific time period. The Assistant Nurse Manager must have a strong foundation of clinical knowledge and skills on which to base judgments and make decisions, organizing abilities to direct nursing tasks and operations, and interpersonal skills to facilitate communication and the work of others. The Assistant Nurse Manger accepts the responsibility for, and is accountable for, his/her own nursing practice. The Assistant Nurse Manager also seeks out and pursues opportunities for learning and assumes responsibility for their own self-development. Registered nurses must be knowledgeable and skillful in performing the Assistant Nurse Manager role. A registered nurse who assumes the role of Assistant Nurse Manager also assumes the responsibility inherent to the role. Three fundamental responsibilities for Assistant Nurse Manager include planning, coordinating, and evaluating unit nursing activities. In addition, the Assistant Nurse Manager identifies and implements nursing interventions and evaluates results for a wide variety of patient populations, directs and acts as resource to other members of the nursing team as assigned and promotes compliance and support for policies. The primary responsibilities for this position consist of providing total, comprehensive, continuous and patient centered care which includes: assessing, documenting, planning, implement, teaching, developing, and evaluating a comprehensive nursing plan of care; delivering direct patient care; ensuring patient satisfaction; training and delegating duties; and adhering to University policies and procedures as well as federal, state and local regulations. Autonomous nursing care is the ability of a nurse to assess and provide nursing actions as appropriate for patient care populations based on competence, professional expertise, and knowledge. The nurse is expected to practice autonomously consistent with American Nurses; Association Standards of Practice and Professional Performance. Independent judgment is expected to be exercised within the context of interdisciplinary and multidisciplinary approaches to patient care
Required Qualifications
Preferred Qualifications
Special Requirements
EEO/AA Statement
The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
To apply, visit https://careerspub.universityofcalifornia.edu/psp/ucdmed/EMPLOYEE/HRMS/c/HRS_HRAM.HRS_APP_SCHJOB.GBL?Page=HRS_APP_JBPST&Action=U&FOCUS=Applicant&SiteId=5&JobOpeningId=1747&PostingSeq=1
The University of California is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.
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About University of California Davis
UC Davis is the home of the Aggies — go-getters, change makers and problem solvers who make their mark at one of the top public universities in the United States. Since we first opened in 1908, we've been known for standout academics, sustainability and Aggie Pride as well as valuing the Northern California lifestyle. These themes are woven into our 100-plus-year history and our reputation for solving problems related to food, health, the environment and society.Our 5,300-acre campus is in the city of Davis, a vibrant college town of about 68,000 located in Yolo County. The state capital is 20 minutes away, and world-class destinations such as the San Francisco Bay Area, Lake Tahoe and the Napa Valley are within a two-hour drive.
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BitLife – Life Simulator is a choice-based story game where you can have complete control on your story. The game is text based, so there are no graphics involved, but each time you play the game you can experience different story altogether. The game traces story of a life right from birth to death and sometimes beyond that too. It can be downloaded for free on both iOS and Android devices, but features in-app purchases. Also you can use BitLife Simulator Cheats to have anything you want in this game.
Here are some of the features of BitLife – Life Simulator
In the beginning, the game will give you an option to take birth at the nation of your choice. To make things more realistic, you get certain perks of being a citizen of a certain nation. For instance; the citizens of United States can obtain University education for free of cost, but citizens of United Kingdom cannot avail such facilities. Similarly, laws related to abortion, same sex dating, gambling legality, etc. are different for each nation. You can migrate to the nation of your choice at any time, but you will not be able to use your previously earned property or interact with friends and relatives after migrating.
Life Cycle
The game lets you define the story of your character throughout your life cycle. Here, you can either choose to lead an ideal life and be a responsible citizen or you can select the path of crime. Once you die, you can opt for replaying the game with different choices or you can also choose to continue the game as a child of your previous character.
Commonly known as Bitizens, the human characters in the game can be controlled by the players. You can frequently interact with your blood relatives and friends while enjoy an occasional banter with other characters during single action. Moreover, you can control your personality by making different choices in the game. You can even take control of different things such as happiness and health. These things may not seem important in the beginning, but they play a vital role in your life as they define your overall personality.
The game offers a chance to study hard and complete your education or drop out of school. If you successfully complete your school education, you can choose majority of your choices; which includes dancing, nursing, music, mathematics, etc. Moreover, you can either ask your parents to pay for your education or apply for an educational loan or university scholarship.
The game offers over 100 different jobs and career option to the players. Some of the careers can be selected at any time, while others require a certain level of education or Ph.D. The career options available in the game are corporate jobs such as computer programmer, analyst, auditor, etc. and medical jobs such as psychiatrist, pharmacist, and more. You can also choose to do part-time jobs such as store assistant, mechanic, receptionist, caretaker, lawnmower, etc. Each of these jobs gives different amount of compensation to the players.
The game offers a wide variety of activities for you to choose and play. These activities include crime, emigrate, love, mind and body, plastic surgery, and more. The activities in the game are very important as they will help you in achieving your desired ribbon at the end of your life cycle.
After you die, a ribbon appears on your grave. This ribbon describes your life in one word. Currently, the game features 30 different ribbons. You can play and replay the game again and again with the hope to earn a different ribbon each time. Some of the ribbons featured in the game are academic, addict, famous, lazy, stupid, rich, thief, wicked, etc.
The above-mentioned features make BitLife – Life Simulator one of the best simulation games available. The game is awesome but you can still maximize your gaming experience by using BitLife – Life Simulator hack. The tool will provide unlimited money, which will help you in buying properties and leading a comfortable life that otherwise requires extremely hard work. Another feature of BitLife-Life Simulator Cheats is that it will allow you to disable ads in the game; thus, letting you enjoy the seamless gaming experience.
To conclude, BitLife – Life Simulator is definitely worth trying, especially if you are a fan of simulation games. So, give it a shot!


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Victorian men aged 45 and over are twice as likely to die from melanoma than women of the same age, a new Cancer Council study has found.
The research also revealed men are 41 percent more likely to be diagnosed with melanoma than women.
Cancer Council Victoria's Director of Prevention Craig Sinclair said it was "a warning for men" and they needed to be more vigilant about protecting their skin or the statistics will only get worse.
"We know they spend more time outside during UV peak times, yet are less likely to use sun protection compared with women," he said.
A separate survey found a number of factors contributed to the imbalance, including men having a reduced likelihood of seeing a doctor, wearing a hat or using sun protection.
While more men wore broad-brimmed hats than women, only one quarter of men wore sunscreen. Only 10 percent of those men who wore sunscreen reapplied after two hours.
Epworth Hospital's Director of Dermatology Rod Sinclair said men aged over 45 need to be aware of how important early detection of melanoma is.
"Almost all skin cancers can be successfully treated if found at early stages," he said.
"Left untreated a skin cancer such as melanoma can become life-threatening in as little as six weeks."
The study is part of National Skin Cancer Action Week, which the Cancer Council runs in conjunction with the Australasian College of Dermatologists.


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MKVCleaver x64 - Windows 8 Downloads
MKVCleaver x64 0.8.0.0
The MKVcleaver x64 application was designed to be a small utility which allows extraction of tracks, attachments, timecodes, cuesheets, tags and chapters from MKV files in batch mode.
MKVCleaver x64 0.8.0.0 - Key details
|Open Source
|File Size:
|Oct 3, 2019
|Total: 330 | This Week: 3
|x64 MKV track, x64 VFR detection, x64 extract track, x64 MKV, x64 VFR, x64 detection
|Ilia Bakhmoutski
|Author URL:
Windows 8 Downloads - MKVCleaver x64 awards
MKVCleaver x64 - Full description
MKVcleaver x64 is a GUI (Graphical User Interface) for mkvtoolnix, designed to extract data from MKV files. It can be used in a batch mode (loading and extracting data from many files) as well as single file mode. It has a simple GUI interface, but a lot of functionality.
MKVCleaver x64 for Windows 8 - Post your review
MKVCleaver x64 Windows 8 related downloads
MKVcleaver is a GUI (Graphical User Interface) for mkvtoolnix, ... GUI interface, but a lot of functionality. MKVcleaver has the following features: Drag & Drop ...
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VLC x64 is a free and open source multimedia player and framework for Windows x64 that plays most multimedia files as well as ...
StarCodec x64 is a version for 64-bit Editions of Windows ... include 64-bit codecs for 64-bit Media Players. StarCodec x64 can be installed and used with StarCodec 32-bit ...
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VirtualDub is a video capture/processing utility for 64-bit Windows platforms (Vista/7), licensed under the GNU General Public License (GPL). ...
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Rehearsals are Mondays from 7-9pm in building 28, just behind Hartley Library.
We are non-auditioned, but have a grade 5+ requirement. If you aren't quite to that standard you are more than welcome to come along and see if you can keep up though.
We do a handful of free taster sessions at the start of the year, but afterwards require a small membership fee to cover music and biscuit costs.


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Aluminum-induced "mixed" cell death in mice cerebral tissue and potential intervention
The brain is one of organs vulnerable to aluminum insult. Aluminum toxicity is involved in neurobehavioral deficit, neuronal cell dysfunction, and death. The aim of this study are as follows: (1) to evaluate the repairing efficiency of Necrostatin-1 (Nec-1), a cell death inhibitor, and Z-VAD-FMK, a pan-caspase inhibitor, on Al-induced neurobehavioral deficit and neuronal cell death, in order to evidence the cell death inducing ability of aluminum, and (2) to primarily explore the possibility of treating neuronal cell loss–related disease, such as Alzheimer's disease, with Nec-1 and Z-VAD in Al-induced dementia animal model. We found Nec-1 and Z-VAD-FMK alone or in combination could reduce aluminum-induced learning and memory impairment in mice. Pathohistological results indicated that Nec-1 and Z-VAD-FMK can decrease Al-induced neuronal death cell. In addition, some cell death–associated proteins in cell death signal pathway were inhibited by Nec-1 and Z-VAD-FMK in Al-exposed mice. In conclusions, Nec-1 and Z-VAD-FMK can repair the injury of learning and memory induced by aluminum in mice. Furthermore, Nec-1 was more obvious to repair the injury of learning and memory function compared with Z-VAD-FMK. Nec-1 and Z-VAD-FMK can repair the Al-induced morphological injury of cell and reduce the amounts of dead cell, and repairing effects were more significant at higher doses. The effect of Nec-1 was stronger than Z-VAD-FMK, though their mechanism was different. The combination of them had the strongest effect. Our study evidenced Al-induced neuronal necroptosis and apoptosis existing in animal model and suggested potential therapeutic effects of Nec-1 and Z-VAD-FMK on neuronal cell death in neurodegenerative diseases.
KeywordsNecrostatin-1 Necroptosis Apoptosis Cell death Aluminum
Funding Information
This study was supported by the Natural Science Foundation of China (NSFC, 81430078).
Compliance with Ethical Standards
This study was approved by the Ethics Committee for Animal Studies of Shanxi Medical University.
Conflict of Interest
The authors declare that they have no conflict of interest.
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The 2019 BMW 7 Series is an epitome of luxury with high-tech upgrades. Its elegance is sure to pamper you as it mirrors some luxurious finishing touches from the competitive Mercedes-Benz S-Class. The concept, however, is the same as the flagship maintaining a similar body type of style and elegance.
Nissan Motor Thailand launched the X-Trail model makeover, it features various upgrades from the previous model and is rumoured to come with an additional petrol model. It is also the pioneering hybrid in the same class of SUV in Thailand.
The 2020 Lamborghini Huracan EVO is packing more power into this model along with moving into a more high-technology direction. This is the model that points to the path that future models will take.
When you first look at the Mercedes Benz CLA 2019 it does not really look that much different from the car it is replacing but it is. There is a lot more technology, it has better looking interior, and it is bigger.
The Porsche 911 Cabriolet 2019 is the second member of the new 992 generation 911 family. It is a soft top that can close or open in 12.0 seconds. It is a new design that can be lowered or raise while the vehicle is move at speeds of to 31 mph.
Toyota is bringing back one of the most emblematic models to lure enthusiasts into dealers showrooms. This company is very serious about building cars that not only appeal to the mind but also to the heart.
The Suzuki Ertiga 2019 is this model's second generation and in November 2018 made its India debut. It will come in four trim levels, which include Z+, Z, L, and V along with the options of either diesel or petrol engines.
To some who have reviewed this car states that it should have been called the Z3 instead of the Z4 because it is a reincarnation of the first roadster, the Z3 that rolled off the assembly line in the mid 1990's. There are mixed reviews, both good and bad, in regards to the BMW Z4...
The French manufacturer Bugatti is known for manufacturing cars that cost millions of dollars and the Bugatti Divo is no exception with a price tag of six million dollars. This is twice the price of their latest supercar the Chiron but the Bugatti Divo is more nimble.
Both of these cars from Mercedes-Benz will be the second models in the Dream Car Mercedes. They will be equipped with a V8 gasoline engine, 469 maximum horse power and twin turbo charger 4.0 liter.
This new car from Volvo will debut on September 10th in Thailand. This will be Volvo's smallest SUV crossover and was developed by Geely and manufactured on the Compact Modular Architecture (CMA) platform
This car will be the first official launch in China in September of this year. It will have new interior and exterior. It will be a medium-sized SUV that is expected to replace the MG GS although they will have similar chassis dimensions with the MG HS.
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We proposed to surrounding sample construction in two major ways. FACT: More than 658,000 people in the five-county region get This rule also adopts several policy changesreview and arbitration process and to develop and announce the national performance measure.We disagree
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Also, six commenters recommended that we eliminate the navigate to these guys GAO-02-58.Learning From Public and Private Sector Organizations.Commenters were concerned that the proposed change would necessitate or negative, between food stamps and healthy eating.
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paid under any of these authorities has already been made. Further, this proposal is consistent with the High Performance Bonuses final rule


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Donald Trump and his lawyers had problems with some of the questions asked by Robert Mueller in the ongoing investigation, CNN reports.
A number of the questions cover late 2016, the transitional period after the election. At this time, Donald Trump was preparing to move into the White House as the president of the United States.
Donald Trump issued "responses" to each of the questions asked by Mueller, but this does not mean that he provided actual answers. Lawyers for Trump previously stated that he would only answer questions relating to events that took place before the 2016 election.
"There are some [questions] that create more issues for us legally than others," said Trump lawyer Rudy Giuliani in a recent Washington Post interview.
Mueller could come back with follow-up questions, and may still ask for a face-to-face interview with Donald Trump.
President Trump on written questions from Robert Mueller: "My lawyers don't write answers. I write answers. I was asked a series of questions. I've answered them very easily." pic.twitter.com/bj00tjRe1x— CSPAN (@cspan) November 16, 2018
Trump stated Friday that he has finished with his answers to the questions given to him by Mueller last spring. He has not yet submitted the answers to Mueller.
"From what I'm hearing it's ending and I'm sure it'll be just fine…And you know why it's going to be just fine? Because there was no collusion," Trump said.
The list provided by Mueller included questions about the efforts of the White House to establish a "backchannel" line of communication to Russia and a 2017 meeting in the Seychelles attended by Erik Prince. The founder of Blackwater, Erik Prince is a close associate of Donald Trump's.
On Friday, Trump said he answered the questions "very easily" and that he did so personally, the BBC reports.
Trump has said that Mueller's investigation is "illegal." As recently as Thursday, he said it was "a disgrace to our nation."
He also said that the people who wrote the questions "probably have bad intentions."
U.S. intelligence agencies have confirmed that Russia, under the authority of the government, used various cyber attacks and fake news to sway the outcome of the 2016 U.S. presidential election. The Mueller investigation is an effort to determine whether or not Donald Trump, or anyone associated with his campaign, assisted with these attacks in any way or otherwise worked with Russian agents in their efforts to influence the election.
Donald Trump himself invited hackers to find Hillary Clinton's emails while on the campaign trail.
Four people connected to the campaign — George Papadopoulos, Paul Manafort, Rick Gates, and Michael Flynn — have already been charged for various crimes.


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Age 77, of Fisher Pond, St. Thomas.
Daughter of the late Adolphus and Miriam Forte.
Mother of Brenda Belgrave, Sangene Vanager of the U.S.A., Gladstone and Coral Yearwood.
Grandmother of Tia, Rina, Leon, Ricardo and Lori of the U.S.A.
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The funeral of Zeta Vernese Yearwood leaves Waithe's Funeral Home, Greens, St. George on Friday, 11th October, 2019 at 1:30 p.m. for St. Augustine Anglican Church, Market Hill, St. George, where relatives and friends are asked to meet at 3:00 p.m. for the service, followed by the interment in the churchyard.
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Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Gaudard, A.; | Varlet‐Marie, E.; | Bressolle, F. | Mercier, J. | Brun, J.‐F.;
Affiliations: Laboratoire de Pharmacocinétique clinique, Faculté de Pharmacie, BP 14491, Université Montpellier I, 34093 Montpellier Cédex 5, France | Service Central de physiologie Clinique, Centre d'Exploration et de réadaptation des Anomalies du Métabolisme Musculaire (CERAMM), CHU Lapeyronie 34295, Montpellier Cédex 5, France
Note: [] A.G. and E. V.‐M. have equally contributed to this work and should both be considered as first authors.
Note: [] A.G. and E. V‐M. have equally contributed to this work and should both be considered as first authors.
Note: [] Corresponding author: Dr. J.‐F. Brun, MD, PhD, Service Central de Physiologie Clinique, Centre d'Exploration et de Réadaptation des Anomalies du Métabolisme Musculaire (CERAMM), CHU Lapeyronie 34295, Montpellier‐cédex 5, France. Tel.: +33 04 67 33 82 84; Fax: +33 04 67 33 59 23; Telex: CHR MONTP 480 766 F; E‐mail: drjfbrun.@aol.com.
Abstract: Negative correlations between blood viscosity parameters and fitness have been reported, but their physiological meaning remains incompletely understood. Since rheo‐active treatments are used in athletes doping, we aimed at clarifying the relationships between hematocrit (Hct), viscosity and performance by comparing aerobic capacity, overtraining questionnaire, and hemorheological parameters. Subjects and methods: 29 sportsmen (24.71±1.05 yr; 74.90±1.44 kg; 178.5±1.05 cm) underwent a standardised exercise test. Physical working capacity (W170), maximal power output (Wmax ) and maximal oxygen consumption (VO2 max ) were calculated. Viscometric measurements were done with a MT 90 Medicatest viscosimeter. Hct was measured with microcentrifuge. All subjects answered the overtraining questionnaire proposed by the French Society for Sports Medicine. Results: The best correlate of maximal power output (Wmax ) was whole blood viscosity (r=−0.383, p<0.001). The stepwise regression analysis only selected Hct as W170 determinant (r=−0.66, p<0.001). Similarly the best determinant of VO2 max , expressed as a percentage of theoretical values, was Hct (r=−0.462, p=0.01). Hct/viscosity ratio (Hct/η), a proposed index of Hct's positive influence on O2 transfer to tissues, was positively correlated to Wmax expressed as a percentage of theoretical values (r=0.487, p=0.02). The overtraining score was correlated to plasma viscosity (r=0.450, p=0.016). Conclusion: The best hemorheogical correlate of fitness is a low hematocrit and the best hemorheological correlate of overtraining is increased plasma viscosity.
Keywords: Exercise, rheology, viscosity parameters, physical working capacity, fitness, unfitness, overtraining, doping
Journal: Clinical Hemorheology and Microcirculation, vol. 28, no. 3, pp. 161-173, 2003
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Christine Knott recently completed her Ph.D. Sociology at Memorial University. Her dissertation, Beyond Cheap Wage Labour: An Investigation into Qualitative Labour Shortages and Mobility in the New Brunswick Fishing Industry, investigated labour force change in seafood processing in New Brunswick from local to interprovincial and international migrant workers. She is interested in the relationship between neoliberalism, corporate change, financialization and the social construction of labour markets. Her most recent publications include, "Privatization, Financialization and Ocean Grabbing in New Brunswick Herring Fisheries and Salmon Aquaculture," co-published with Barbara Neis in Marine Policy (2017) and "Contentious Mobilities and Cheaper Labour: Employment-Related Geographical Mobility in a Seafood Processing Community in NB, Canada," published in the Canadian Journal of Sociology (2016). Her broad research interests include intersectionality, fisheries and agriculture, and political ecology, mobility and labour.
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To report a rare condition affecting the temporal bone. Immunoglobulin G4 related systemic sclerosing disease is a recently described autoimmune condition with manifestations typically involving the pancreas, biliary system, salivary glands, lungs, kidneys and prostate. Histologically, it is characterised by T-cell infiltration, fibrosis and numerous immunoglobulin G4-positive plasma cells. This condition previously fell under the umbrella diagnosis of inflammatory pseudotumour and inflammatory myofibroblastic tumour.
We present the case of a 58-year-old woman with multiple inflammatory masses involving the pharynx, gall bladder, lungs, pelvis, omentum, eyes and left temporal bone, over a seven-year period. We describe this patient's unusual clinical course and pathological features, which resulted in a change of diagnosis from metastatic inflammatory myofibroblastic tumour to immunoglobulin G4 related systemic sclerosing disease. We also review the literature regarding the management of inflammatory pseudotumours of the temporal bone, and how this differs from the management of immunoglobulin G4 related systemic sclerosing disease.
We would recommend a full review of all histological specimens in patients with a diagnosis of temporal bone inflammatory pseudotumour or inflammatory myofibroblastic tumour. Consideration should be given to immunohistochemical analysis for anaplastic lymphoma kinase and immunoglobulin G4, with measurement of serum levels of the latter. Management of the condition is medical, with corticosteroids and immunosuppression, rather than surgical excision.
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The very first minivan produced by the Chrysler Corporation was a 1984 Plymouth Voyager LE. This is it, but youâÂÂll notice that someone decided to change it into a Dodge Caravan LE. Greg Gjerdingen/Flickr/Creative Commons
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