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Tele Columbus AG / Key word(s): Profit Warning/Half Year Results
Berlin, 28 August 2018.
The management board of Tele Columbus AG (ISIN: DE000TCAG172, WKN: TCAG17) today adjusted its guidance for the FY 2018.
As planned, the Pepcom customer migration was completed successfully at the end of June 2018. In the past weeks the Company has been driving the integration of the Group's accounting platforms into a single ERP system. This part of the overall integration will be completed by the beginning of September 2018.
Due to the finalization of the overall integration project in combination with marketing activities starting in October 2018 the new management board expects a higher recurring cost base and revenue growth delayed. Based on net sales of EUR 240 million and a Normalized EBITDA of EUR 118 million for the first half of 2018, the new management board has therefore decided today to adjust its FY 2018 outlook as follows:
- Stable homes connected
- Stable revenues year on year
- Normalised EBITDA of at least EUR 235 million
- Maximum capex of EUR 150 million
The Normalised EBITDA target includes a significant ramp-up of marketing spend in the second half of 2018. Furthermore, the management board expects significantly reduced non-recurring costs year on year in the second half of 2018 translating into a largely stable year on year development of the Reported EBITDA for FY2018.
The management board will publish the financial results for the first half year 2018 latest by 31 August 2018. The management board will provide an update on the growth path for the company early 2019.
About us
The SDAX-listed Tele Columbus AG serves 3.6 million homes connected thereby being Germany's third-largest cable network operator. Its brand PŸUR stands for simplicity, performance and fairness in relation to TV and telecommunication products. Via its state-of-the-art fibre network PŸUR offers high-speed broadband internet including fixed-line telephony as well as more than 250 TV channels on a digital entertainment platform which combines linear TV with streaming services. To its housing association partners PŸUR offers flexible models of cooperation and state-of-the-art services such as telemetric and tenant portals. As a full-service partner for municipalities and regional utilities Tele Columbus Group is actively supporting the fibre-based broadband internet expansion in Germany. For its business customers the Group offers carrier services and corporate solutions via its fibre network. Besides its headquarter in Berlin the Company has locations in Hamburg, Leipzig, Ratingen and Unterföhring/Munich. Since January 2015 Tele Columbus AG is traded on the regulated market (Prime Standard) of the Frankfurt Stock exchange and since June 2015 listed in the SDAX.
This release may contain forward-looking statements. These statements reflect the Company's current knowledge and expectations and projections about future events. By their nature, forward-looking statements involve a number of risks, uncertainties, assumptions and other factors that could cause actual results or events to differ materially from those expressed or implied by the forward-looking statements. Such risks, uncertainties and assumptions may cause our actual results, performance or achievements to differ materially from those expressed or implied by such forward-looking statements. In light of these risks and uncertainties, the forward-looking events and circumstances discussed in this release may not occur and actual results could differ materially from those anticipated or implied in the forward-looking statements. Accordingly, investors are cautioned not to place undue reliance on the forward-looking statements, which speak only as of the date of this document.
This release contains references to certain non-GAAP financial measures, such as Normalized EBITDA and Capex, and operating measures, such as RGUs, ARPU, and Unique Subscribers calculations. These non-GAAP financial and operating measures should not be viewed in isolation as alternatives to measures of the Company's financial condition, results of operations or cash flows as presented in accordance with IFRS. The non-GAAP financial and operating measures used by the Company may differ from, and not be comparable to, similarly titled measures used by other companies.
All information contained in this release has been carefully prepared. However, no reliance may be placed for any purposes whatsoever on the information contained in this document or on its completeness. No representation or warranty, express or implied, is given by or on behalf of the Company or any of its directors, officers or employees or any other person as to the accuracy or completeness of the information or opinions contained in this document and no liability whatsoever is accepted by the Company or any of its directors, officers or employees nor any other person for any loss howsoever arising, directly or indirectly, from any use of such information or opinions or otherwise arising in connection therewith. The Company does not undertake any obligation to update or revise any information contained in this release, including forward-looking statements, whether as a result of new information, future events or otherwise.
Silke Bernhardt
Director Corporate Communications
Phone +49 (30) 3388 4177
Fax +49 (30) 3388 9 1999
28-Aug-2018 CET/CEST The DGAP Distribution Services include Regulatory Announcements, Financial/Corporate News and Press Releases.
|Tele Columbus AG
|Kaiserin-Augusta-Allee 108
|10553 Berlin
|+49 (0)30 3388 4177
|+49 (0)30 3388 9 1999
|Regulated Market in Frankfurt (Prime Standard); Regulated Unofficial Market in Berlin, Dusseldorf, Hamburg, Munich, Stuttgart, Tradegate Exchange
|End of Announcement
|DGAP News Service

subset: commoncrawl


text:
Bunkbeds meet standards in style
Related Articles
- Bedding. // Furniture/Today;3/21/2011, Vol. 35 Issue 28, p48
The article lists several bedding companies located in High Point, North Carolina including Cadence Keen Innovations, Glideaway Sleep Products, and Specialty Sleep Association.
- Simmons to appear at market. // Furniture/Today;09/04/2000, Vol. 25 Issue 1, p6
Reports on the return of bedding major Simmons for a one-time appearance in October 2000 to display a pair of new lines in High Point, North Carolina. Simmons' plan to showcase its revamped BackCare line; Reasons why the company's decided for a one-time appearance in October.
- HP bed newcomers shine. Perry, David // Furniture/Today;5/7/2013, Vol. 37 Issue 36, p68
The article discusses the bedding industry related trade show High Point Market that was held in High Point, North Carolina in April 2013 in which several newcomers bedding manufacturing firm have exhibited their products including Cellupedic, Campbell Mattress Co. and Emerald Sleep Systems.
- NEW AT MARKET: BEDDING/METAL BEDS. // Furniture/Today;4/5/2004, Vol. 28 Issue 31, p30
Provides information on bedding and metal-bed introductions to be made by exhibitors at the April 2004 International Home Furnishings Market in High Point, North Carolina. Charleston Forge's additions to its Shaker bed collection; Metropolitan Designs' Source platform bed; Weil's Sleep...
- About the distribution numbers. // Furniture/Today;02/05/2001, Vol. 25 Issue 22, p38
Reports the compilation of the furniture industry statistics on retail distribution done by Furniture/Today through the assistance of bedding manufacturers in High Point, North Carolina. Importance of the data for business planning; Combination of the market share percentages; Organizational...
- Bedding producers plan to be aggressive. Thomas, Larry // Furniture/Today;04/16/2001, Vol. 25 Issue 32, p192
Reports that bedding producers in High Point, North Carolina, are seeking retail placements in an effort to build sales momentum. Retail performance of the category in February 2001; Impact of economic fluctuations on bedding manufacturers; Market rollouts in the Bemco, Natura, United Sleep...
- Bedding boosts biz with product, promos. Thomas, Larry // Furniture/Today;10/15/2001, Vol. 26 Issue 7, p174
Reports on the efforts of manufacturers to boost the bedding industry by introducing latest products in High Point, North Carolina. Importance of effective products and promotions; Enumeration of manufacturers and products introduced; Features and retail price of the products.
- Comfortaire returns to High Point market. // Furniture/Today;10/15/2001, Vol. 26 Issue 7, p174
Reports on the return of bedding manufacturer Comfortaire in the bedding market in High Point, North Carolina.
- Bedding coverage expands. Perry, David // Furniture/Today;1/13/2003, Vol. 27 Issue 19, p40
Reports on the expansion of the bedding coverages of the journal 'Furniture/Today' in High Point, North Carolina. Discussion of issues concerning the bedding industry; Presentation of news and feature items; Inclusion of the column Bedding Benchmarks.


text:
Talk:Hellknight Hill (adventure)
From PathfinderWiki
PageDiscussionMetaView sourceView history← $1
(Adventure) [RESOLVED]
I have just looked at the adventure and it states that in-world, 'Hellknight Hill' is simply an informal synonym for the site of Citadel Altaerein. Is it truly necessary to keep this page name as it is now, or can it be moved back to simply 'Hellknight Hill' (with a disambiguation note), like we did with Temple of the Peacock Spirit? - HTD (talk) 02:17, 2 August 2019 (UTC) -Oznogon (talk) 11:55, 26 October 2019 (UTC)


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By Guest iyseal, June 10, in soompi hangout. I'm very liberal and I'd be fine with her dating someone older since she's very mature and smart, but I think a married man 30 years her senior is too much at this. You know those girls who refuse to date anyone younger than they are, much less anyone their own age?
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text:
Ikumi Nakamura and Hideki Kamiya tease new Okami game
If you've been patiently waiting for a new game in the Okami series, you may very well get your wish.
If you've been patiently waiting for a new game in the Okami series, you may very well get your wish.
Nintendo's newest IP looks like an action-packed paradise in its launch trailer.
Platinum Games put together a dream team to create Astral Chain. But is it a match made in heaven? Our review.
With so much to digest in Nintendo's E3 2019 Direct, many were left scratching their heads and wondering: Where was Bayonetta 3 at E3 2019?
Nier: Automata is celebrating a massive milestone, with over 4 million copies having been sold since its launch.
The stars could be aligning for a Nintendo Switch exclusive revival of Platinum Games' Scalebound after it was canceled by Microsoft.
Astral Chain marks Platinum Games' latest action effort, and it's coming to Nintendo Switch.
Oh, that rage guy? Today's episode featuring special guest Josh Hawkins. Hey also, beware several (many) poop jokes from Buffa.
Become one hell of an oni-slayer in this new mobile adventure.
The new kid on the block is hanging tough while he waits for his most anticipated games of 2018 to launch.


text:
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Support: 24355 / -
Resistance: 25000 / 25275
Chart (H4)


text:
hugh bowman
What you don't know about horse whips
The top three jockeys in the Melbourne Cup were penalised for excessive whipping of their horses. But they reckon there's something the public doesn't know.
The mystery horse challenging Winx's top rank
Australian super mare Winx has been denied the undisputed top rank on the Longines World's Best Racehorse Rankings by champion British horse Cracksman.
Marmelo's Bowman handed one month ban
Marmelo's outstanding second place finish at the 2018 Melbourne Cup has been marred by the news that jockey Hugh Bowman has been slapped with a suspension.
How Winx broke hoodoo to start Cox Plate reign
Winx will start favourite to win a fourth straight Cox Plate today. But the super mare had to run down history to get her first in 2015.
Winx claims world record, George Ryder Stakes
Winx has won a world record 17th Group One race in beating Happy Clapper and Kementari in the George Ryder Stakes at Rosehill.
Bowman in hospital after horror fall
Leading Sydney jockey Hugh Bowman will spend the night in hospital but has escaped serious injury after a fall at Randwick.
Bowman ban leads to Winx schedule change
Winx will not run in the Apollo Stakes with connections opting to wait for the Chipping Norton Stakes after jockey Hugh Bowman completes his suspension.
Winx's return in doubt after Bowman loses appeal
Winx's return to racing in the Apollo Stakes is under review after Hugh Bowman failed to have a careless riding ban reduced in order to ride the champion mare.
Bowman named world's best jockey
Hugh Bowman has been named as the world's best jockey - the first Australian to win the award.
Bowman world's best after Japan Cup win
Australian Hugh Bowman has claimed the Japan Cup aboard Cheval Grand to secure the title of world's leading jockey, with defending champion Kitasan Black third.


text:
The fine folks at Richmond Good Life -- the same folks who brought you the essential blow-by-blow coverage of Richmond's last mayoral race and who have seemingly fallen head-over-heels for The Checkout Girl -- have created another essential Richmond resource. Yes, they've gathered together a running list of the 6,438 Richmonders who you ought to be following on Twitter.
For the record, I'm loitering at Twitter during the daytime hours.


text:
Published on
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For Sale $299,500 USD - House
Carr. chapala jocotepec #960 –23— $299,500 USD LOVELL
When entering the lush grounds of La Reserva it is like entering a park – many varieties of mature trees, manicured lawns interspersed with huge bunches of tall fluffy pampas grass and only the sound of birds chirping. What a welcome! Double 24/7 security gives you the added feeling of complete safety – all this only a few minutes west from central Ajijic.
If you want light, bright and total class, this 3 bedroom, 3 bath solar electric house is for you – right from the skylights, to the atrium with a zen water feature, to sliding doors from the great room and master leading onto a perfect size yard – complete with a lovely cantera and talevera tile fountain. In fact, the entire central area opening to the great room is one large skylight with fabulous palm wood beams!
The kitchen has light contemporary style cupboards, granite countertops and backsplash two lazy susans, stainless steel Whirlpool appliances and to add character and even more light, a charming cupola! This house is a home.
Both the great room and master have the beautiful curved brick panuelo ceilings with surround subtle lighting and the centrally situated fireplace has a gorgeous carved wooden mantel and a very attractive antiqued screen.
Another wonderful feature is the curved wooden door leading to the master which is completely separate from the other two bedrooms, offering complete privacy. All the closets have built in shelves and drawers and the master has a nice sized walk in closet. The third bedroom currently used as a den/tv room has a fabulous custom built wall unit. The great room and den/third bedroom have a mini-split which cools and heats depending on the time of year.
This pristine home is being sold with very high end custom built furnishings. Do not delay – call today!
- Solar Electric
Double 24/7 Security
Originals owners
- Property Tax Approx:158 USD
- Appliances: Dish washer, Oven, Refrigerator, Garbage disposal, clothes Washer, Microwave, Stove
- Fees approx: $132 Quartely USD Fees include: Common maintenace, Garbage, Security, Exterior maintenance, Street Lighting
- Lot:440 SIZE m2 – 4,736 SIZE sq ft Const: 236 SIZE m2 – 2,540 SIZE sq ft
- 110v & 220V electrical
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- One level
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- Parking 2 or more
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- Walled/Fenced
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- Yard/Jardin


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· In 2017, state voters passed new laws affecting the Texas cash-out refinance loan. texas borrowers should take note of these friendlier rules. Among the changes: You can now refinance.
Texas VA Refinance – Texas Veterans Home Loans – Eligible Texas veterans and active-duty personnel can refinance with a regular Texas VA refinance or a VA Streamline refinance or to lower their rate, shorten their term, or eliminate mortgage insurance (PMI).. Due to strict home equity laws in the state of Texas, VA cash out refinances are.
cash out refi vs home equity loan Cash-out refinancings use the home's increased equity as collateral to extract money. After the refinancing, the borrower has a new loan, but with a larger amount of debt on the house. HELOCs leave.cash out refinance seasoning requirements refinance with cash out or home equity loan Home Equity Loan vs. Cash-Out Refinance: Which is Better? – Although a cash-out refinance has a higher upfront cost than a home equity mortgage, cash-out refinancing comes with lower out-of-pocket monthly payment expenses, making it the more affordable option for long-term repayment plans.


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It is now clear that SDA's insisting on allocating the realm of finance to HDZ was wrong. Federation BiH is governed in a 'Balkans way' and with magic of reforms. It is not the first time that SDA is giving in to ultimate requests of HDZ, which continues to control all financial flows in the country.
Why is Prime Minister FBiH keeping silent when his deputy, Minister of Finance is fiercely opposing to an economic opportunity to inject much needed additional tax profit into the federal budget that is at present in the state of accumulated deficit of 83 million KM?
Only Federal Institute PIO/MIO (retirement fund) is in the state of accumulated deficit of 170 million KM! This kind of behavior and attitude of someone who runs finance in Federation BiH and who is supposed to fight for increase of public revenue is downright despicable.
Economic measure for recovery of accumulated deficit of 170 million KM of Institute PIO/MIO is taxation of all betting shops and their integration in the VAT system. In practice, that would mean additional 200 million KM tax profits into the FBiH budget to improve livelihoods of our pensioners. Lucky winners would be pensioners. However, instead of being allocated to pensioners, the tax money from lottery games goes to HDZ election campaign.
The latest illustration of inexplicable giving in to HDZ is the example of an episode in parliament which we can colloquially call 'lottery games'. Following a signal from HDZ, SDA withdrew from parliamentary procedure Proposal of law on changes and addendums to the Law on lottery games and Proposal of law on changes and addendums to the Law on tax on income, by which the betting shops were supposed to be taxed additionally!
The last session of Home of Representatives of FBiH Parliament was stopped upon HDZ insisting to remove this item from the agenda. SBB supported HDZ initiative. To show his support, President of FBiH Marinko Cavara hosted a meeting with owners of some of the biggest betting shops in FBiH to hear their complaints about their 'lack of rights'.
In all of the above examples, and there are more of those, so called 'Bosniak unity' embodied in two Bosniak parties SDA and SBB, is silent. Their self-indulgent ministers only care about – themselves.
I wonder if SDA and SBB have enough courage to confront finance imperors of BiH, that is HDZ BiH.
SBB will continue to observe and vote according to instructions they get from SDA. On the other hand, SDA will start to pretend to be in conflict with HDZ, as part of their pre election campaign. For sake of public perception, they will pretend to have fulfilled all requests and wishes of HDZ.
The perception of BH public is that SDA is fulfilling all political requests of HDZ. That perception is correct.
By: Prof Dr Dzenan Djonlagic, Federal Representative for Democratic Front
Web stranicu novinske agencije Patria možete pratiti i putem aplikacije za Android


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The Electric Power Hot Line Training - Single Phase Systems course provides participants with the knowledge, skills, and abilities necessary to perform distribution work from an insulated aerial device using rubber gloving, a rubber protective cover-up, and insulated hot line tools on single-phase circuits. During the course, students utilize the TEEX Hot Line training field to perform tasks while elevated almost 40 feet under simulated energized conditions. At the completion of this course, participants are able to select methods and procedures to perform assigned duties on energized circuits under supervision.
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Participants will be required to safety operate machinery and conduct field exercises at a height of approximately 35 feet during this class. In order to successfully complete these exercises, participants must be aware of any medical and/or physical limitations that might prevent them from participating in such activities.
It is recommended, but not required, participants complete the TEEX Bucket and Digger Truck Operations (EPP025) and Electric Power Overhead Line Construction (EPP031) courses. Additionally participants should be qualified to operate an insulated aerial device and have basic construction knowledge of overhead distribution systems.
This course is designed for electric utility personnel who are required to work on energized overhead distribution systems up to and including 34.5 kV.
TEEX Student Portal


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Browsing UMB Open Access Articles 2019 by Publication date
Now showing items 1-20 of 916
Erratum: Author Correction: Immune-checkpoint protein VISTA critically regulates the IL-23/IL-17 inflammatory axis (Scientific reports (2017) 7 1 (1485))A correction has been published and is linked to the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Erratum: Author Correction: A population-specific reference panel empowers genetic studies of Anabaptist populations (Scientific reports (2017) 7 1 (6079))A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Erratum: Author Correction: Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL (Scientific reports (2018) 8 1 (744))A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Use of clomiphene citrate alone, urinary follicle-stimulating hormone alone, or both combined sequentially in patients with unexplained subfertility undergoing intrauterine insemination: A randomized trialObjective: To compare the successes of clomiphene citrate (CC) alone, pure human urinary follicle-stimulating hormone (uFSH) alone, and both combined sequentially in patients with unexplained subfertility couples undergoing intrauterine insemination (IUI). Materials and Methods: Patients aged 18-38 years who had a normal uterine cavity, at least one normal fallopian tube, and regular menses and were unable to conceive despite unprotected intercourse for at least 12 months were randomized to receive CC alone, uFSH alone, or sequential CC and uFSH before a single IUI. The primary outcomes were clinical pregnancy and live birth rates. The study was approved by the ethics committee of our institution. Results: A total of 135 patients were randomized, and 121 of these were able to complete the study. Of these, 30% (n=36) had CC alone, 34% (n=41) had uFSH alone, and 36% (n=44) had sequential CC and uFSH. The three groups did not significantly differ in terms of age, duration of infertility, hormone levels, and semen parameters. For CC alone, uFSH alone, and sequential CC plus uFSH groups, pregnancy rates were 8.3%, 17.1%, and 18.2%, respectively (p>0.05), and live birth rates were 8.3%, 12.1%, and 13.6%, respectively (p>0.05). Conclusion: In women with unexplained infertility, use of uFSH seemed to increase the success rate compared with CC alone. The sequential regime can significantly reduce the treatment cost if gonadotropin/IUI cycles are planned.
Bortezomib and metformin opposingly regulate the expression of hypoxia-inducible factor alpha and the consequent development of chemotherapy-induced painful peripheral neuropathyChemotherapy-induced painful peripheral neuropathy is a significant clinical problem that is associated with widely used chemotherapeutics. Unfortunately, the molecular mechanisms by which chemotherapy-induced painful peripheral neuropathy develops have remained elusive. The proteasome inhibitor, bortezomib, has been shown to induce aerobic glycolysis in sensory neurons. This altered metabolic phenotype leads to the extrusion of metabolites which sensitize primary afferents and cause pain. Hypoxia-inducible factor alpha is a transcription factor that is known to reprogram cellular metabolism. Furthermore, hypoxia-inducible factor 1 alpha protein is constantly synthesized and undergoes proteasomal degradation in normal conditions. However, metabolic stress or hypoxia stabilizes the expression of hypoxia-inducible factor 1 alpha leading to the transcription of genes that reprogram cellular metabolism. This study demonstrates that treatment of mice with bortezomib stabilizes the expression of hypoxia-inducible factor 1 alpha. Moreover, knockdown of hypoxia-inducible factor 1 alpha, inhibition of hypoxia-inducible factor 1 alpha binding to its response element, or limiting its translation by using metformin prevent the development of bortezomib-induced neuropathic pain. Strikingly, the blockade of hypoxia-inducible factor 1 alpha expression does not attenuate mechanical allodynia in mice with existing bortezomib-induced neuropathic pain. These results establish the stabilization of hypoxia-inducible factor 1 alpha expression as the molecular mechanism by which bortezomib initiates chemotherapy-induced painful peripheral neuropathy. Crucially, these findings reveal that the initiation and maintenance of bortezomib-induced neuropathic pain are regulated by distinct mechanisms. Copyright The Author(s) 2019.
A promiscuous kinase inhibitor reveals secrets to cancer cell survivalDeregulated kinase signaling networks drive the growth and survival of many cancer cells. However, the genetic complexity and rapidly evolving nature of most cancer cells create challenges when identifying the most relevant kinases to inhibit to achieve optimal therapeutic benefits. A new strategy that takes advantage of a well-characterized multitargeted kinase inhibitor describes a nongenetic approach to tease out key kinases that promote proliferation of specific cancer cell types. Copyright 2019 Shapiro.
Plasma for burn shock resuscitation: is it time to go back to the future?Patients with burn shock can be challenging to resuscitate. Burn shock produces a variety of physiologic derangements: Patients are hypovolemic from volume loss, have a increased systemic vascular resistance, and may have a depressed cardiac output depending on the extent of the thermal injury. Additionally, the burn wound produces a significant inflammatory cascade of events that contributes to the shock state. Fluid resuscitation is foundational for the initial treatment of burn shock. Typical resuscitation is with intravenous lactated Ringer's in accordance with well-established formulas based on burn wound size. In the past century, as therapies to treat thermal injuries were being developed, plasma was the fluid used for burn resuscitation; in fact, plasma was used in World War II and throughout the 1950s and 1960s. Plasma was abandoned because of infectious risks and complications. Despite huge strides in transfusion medicine and the increased safety of blood products, plasma has never been readopted for burn resuscitation. Over the past 15 years, there has been a paradigm shift in trauma resuscitation: Less crystalloid and more blood products are used; this strategy has demonstrated improved outcomes. Plasma is a physiologic fluid that stabilizes the endothelium. The endotheliopathy of trauma has been described and is mitigated by transfusion strategies with a 1:1 ratio of RBCs to plasma. Thermal injury also results in endothelial dysfunction: the endotheliopathy of burns. Plasma is likely a better resuscitation fluid for patients with significant burn wounds because of its capability to restore intravascular volume status and treat the endotheliopathy of burns.
Circulating and circular RNAs and the need for rationalization and synthesis of the research spiralIn this essay, we aim to draw a short comparison between 2 important research topics - circular and circulating RNAs - and show how they are connected. The findings described here in the field of circular RNAs, which are still quite obscured by the rapidly expanding body of knowledge in biology, have added another dimension to our view of the process of gene expression, which is formed by a more complex network of molecule interactions than we previously thought. The term "circulating RNAs" refers to a broad spectrum of RNA fragments originating from different sources, such as physiologically dying cells, sites of inflammation or cancer cells, and fragments floating in human liquid tissues together with other elements. Fragments of nucleic acids circulating in blood are emerging as promising biomarkers in different medical conditions. Interestingly, circular RNAs have been found to be present in human blood and form a fraction of circulating RNAs. In addition to updating readers on these fast-developing areas of biology, we also stress the need for the study of complex networks of molecule interactions as whole structures (in unison with the thoughts of systems biology), as opposed to the trend toward searching for individual key player molecules. Fundamentally, we want to add to the rationalization and synthesis of new research findings in the scientific literature, because this direction is important not only for students, teachers and researchers, but also for the general population.
Fetal Programming and Sexual Dimorphism of Mitochondrial Protein Expression and Activity of Hearts of Prenatally Hypoxic Guinea Pig OffspringChronic intrauterine hypoxia is a programming stimulus of cardiovascular dysfunction. While the fetal heart adapts to the reduced oxygenation, the offspring heart becomes vulnerable to subsequent metabolic challenges as an adult. Cardiac mitochondria are key organelles responsible for an efficient energy supply but are subject to damage under hypoxic conditions. We propose that intrauterine hypoxia alters mitochondrial function as an underlying programming mechanism of contractile dysfunction in the offspring. Indices of mitochondrial function such as mitochondrial DNA content, Complex (C) I-V expression, and CI/CIV enzyme activity were measured in hearts of male and female offspring at 90 days old exposed to prenatal hypoxia (10.5% O2) for 14 d prior to term (65 d). Both left ventricular tissue and cardiomyocytes exhibited decreased mitochondrial DNA content, expression of CIV, and CI/CIV activity in male hearts. In female cardiomyocytes, hypoxia had no effect on protein expression of CI-CV nor on CI/CIV activity. This study suggests that chronic intrauterine hypoxia alters the intrinsic properties of select respiratory complexes as a programming mechanism of cardiac dysfunction in the offspring. Sex differences in mitochondrial function may underlie the increased vulnerability of age-matched males compared to females in cardiovascular disease and heart failure.
Self-reported infertility, metabolic dysfunction, and cardiovascular events: a cross-sectional analysis among U.S. womenObjective: To explore associations between infertility and metabolic syndrome, and cardiovascular events. Infertility is increasingly a public health issue, with emerging links to chronic disease. Existing literature on infertility focuses primarily on known causes, which likely excludes a substantial number of women for whom there is no known cause or formal diagnosis. Design/Setting: We conducted a cross-sectional analysis examining the association between self-reported infertility (i.e., ever experiencing inability to conceive after 12 months of trying to become pregnant) and metabolic syndrome and cardiovascular events (i.e., congestive heart failure, coronary heart disease, heart attack, or stroke). Data were analyzed using multivariate logistic regression. Patient(s): A total of 744 U.S. women, 20–59 years of age, from the National Health and Nutrition Examination Survey (2013–2014), participated in the study. Among them, 15.7% reported ever experiencing infertility, 27.6% met the definition of metabolic syndrome, and 2.84% reported ever having a cardiovascular event. Intervention(s): N/A. Main Outcome Measure(s): Metabolic syndrome and cardiovascular events. Results: Compared to women who had never experienced infertility, women who reported infertility had a 1.79 (95% confidence interval [CI] 1.04, 3.08) higher odds of reporting symptoms of metabolic syndrome and 1.83 (95% CI 1.15, 2.89) times higher odds of having experienced a cardiovascular event. Furthermore, women with self-reported infertility had a 71% higher odds of reporting a cardiovascular event after controlling for metabolic syndrome (95% CI 1.01, 3.00). Conclusions: Our results suggest that among U.S. women, the experience of infertility at any point in a woman's reproductive window may be associated with later-life cardiovascular health.
Serologic responses to the PfEMP1 DBL-CIDR head structure may be a better indicator of malaria exposure than those to the DBL-α tagBackground: Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP1) antigens play a critical role in host immune evasion. Serologic responses to these antigens have been associated with protection from clinical malaria, suggesting that antibodies to PfEMP1 antigens may contribute to natural immunity. The first N-terminal constitutive domain in a PfEMP1 is the Duffy binding-like alpha (DBL-α) domain, which contains a 300 to 400 base pair region unique to each particular protein (the DBL-α "tag"). This DBL-α tag has been used as a marker of PfEMP1 diversity and serologic responses in malaria-exposed populations. In this study, using sera from a malaria-endemic region, responses to DBL-α tags were compared to responses to the corresponding entire DBL-α domain (or "parent" domain) coupled with the succeeding cysteine-rich interdomain region (CIDR). Methods: A protein microarray populated with DBL-α tags, the parent DBL-CIDR head structures, and downstream PfEMP1 protein fragments was probed with sera from Malian children (aged 1 to 6 years) and adults from the control arms of apical membrane antigen 1 (AMA1) vaccine clinical trials before and during a malaria transmission season. Serological responses to the DBL-α tag and the DBL-CIDR head structure were measured and compared in children and adults, and throughout the season. Results: Malian serologic responses to a PfEMP1's DBL-α tag region did not correlate with seasonal malaria exposure, or with responses to the parent DBL-CIDR head structure in either children or adults. Parent DBL-CIDR head structures were better indicators of malaria exposure. Conclusions: Larger PfEMP1 domains may be better indicators of malaria exposure than short, variable PfEMP1 fragments such as DBL-α tags. PfEMP1 head structures that include conserved sequences appear particularly well suited for study as serologic predictors of malaria exposure. Copyright 2019 The Author(s).
Factors associated with hypertension among adults in Nepal as per the Joint National Committee 7 and 2017 American College of Cardiology/American Heart Association hypertension guidelines: A cross-sectional analysis of the demographic and health survey 2016Objectives This study investigated the determinants of hypertension in Nepal according to both the Joint National Committee 7 (JNC7) and the American College of Cardiology/American Heart Association (2017 ACC/AHA) guidelines. Design Cross-sectional study. Setting This study used data collected from the 2016 Nepal Demographic and Health Survey data. Participants 13 393 weighted adults aged ≥18 years enrolled by a stratified cluster sampling strategy were included in our analysis. Primary and secondary outcome measures The primary outcome was hypertension, which was defined according to JNC7 (systolic blood pressure (SBP) ≥140 mm Hg and/or diastolic blood pressure (DBP) ≥90 mm Hg) and 2017 ACC/AHA guidelines (SBP ≥130 mm Hg and/or DBP ≥80 mm Hg). Antihypertensive medication users were also classified as hypertensive. After descriptive analysis, multilevel logistic regression was applied to obtain ORs. Results About 21% (n=2827) and 44% (n=5918) of the individuals aged ≥18 years were classified as hypertensive according to the JNC7 and 2017 ACC/AHA guidelines, respectively. Following factors were found to be significantly associated with hypertension according to the 2017 ACC/AHA guideline: ≥70 years (adjusted OR (AOR) 5.2; 95% CI 4.3 to 6.2), 50-69 years (AOR 3.9; 95% CI 3.4 to 4.4) and 30-49 years (AOR 2.7; 95% CI 2.4 to 3.0) age groups, male gender (AOR 1.7; 95% CI 1.6 to 1.9), being overweight/obese (AOR 3.0; 95% CI 2.7 to 3.3), residence in provinces 4 (AOR 1.5; 95% CI 1.2 to 2.0) and 5 (AOR 1.5; 95% CI 1.2 to 1.9). No significant association was identified with household wealth status and ecological regions of residence using the 2017 ACC/AHA guideline. Conclusions Per both guidelines, multiple factors were associated with hypertension. Public health programme aiming to prevent and control hypertension in Nepal should prioritise these factors and focus on individuals with a higher likelihood of hypertension irrespective of educational level, household wealth status and ecological regions of residence. Copyright 2019 Author(s).


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Elvira is travelling through the French countryside with her friend Genevieve, searching for the lost tomb of a medieval murderess and possible vampire, Countess Wandessa. They find a likely site in the castle of Waldemar Daninsky, who invites the women to stay as long as they like. As Waldemar shows Elvira the tomb that supposedly houses the countess, she accidentally causes the vampire to come back to life, hungrier than ever. Daninsky has a hidden secret of his own, but will it be enough to save the two girls from becoming Wandessa's next victims?
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Dillards was founded in 1938 by William T. Dillard in Nashville, Arkansas. In 1956, Dilliard led a group of investors that purchased a department store in Tyler, Texas. The store became Dillard's Mayer & Schmidt. In 1960, a failing store
Where To Buy Souvenir Hard Rock Glasses But there's no need to buy a fancy Hallmark card. Alternatively, it's common for religious Israelis to rock out to Jewish house or techno music during their wedding party. Religious couples may. Barry Weiss Storage Wars Car Collection Jan 29, 2013 · Barry
Daily updates of everything that you need know about what is going on in the military community and abroad including military gear and equipment, breaking news, international news and more.
HRSD provides regional wastewater treatment to 18 cities and counties in southeast Virginia, operating nine major treatment plants in Hampton Roads and four smaller plants on the Middle Peninsula. For questions about service or billing please contact us at 757-460-2491 or by email at [email protected]
SEE MORE VIDEOS All Newport News Public Schools classes. The School Board work session is also postponed. City trash collection will be delayed by one day. Monday collection will be picked up.
Garbage / Bulk / Recycling Collection Schedule & Calendar. The City of Newport News collects household trash, bulk/brush debris, and recyclable material on a.
THE Bull Sheet. Website presented by Allen Brougham. News. CSX Locomotive Roster. Calendar of Events. Bulletin Board. Features. Railroad Interlocking Towers. Amtrak Long-Distance Train Performance
Read about the Newport News Garbage Program – what can and cannot be. Containers may be set out after 3 PM the day before the scheduled collection, and.
May 14, 2019 · Local Car Hobby events for Tidewater Virginia and the Mid-Atlantic Region; including Clubs, Cruise-Ins, Meets, Shows, Driver's Ed, Auto-Cross/Solo, Clubs, etc.
Place your cart three feet away from your trash cart, mailbox, cars, etc. You may set out your container after 3 PM the day before the scheduled collection, and it.
The Bellevue Chamber of Commerce has issued a press release stating that Bellevue's Avenue of Flags will continue for the 20th year! This program was in jeopardy since the city facility that these flags were stored at for the winter was overcome by flood waters this year.
Newport started changes to its recycling schedule, and is still thinking over the merits. Containers would be for both recycling and garbage collection. Pelliterri would provide the containers in.
citizens can place leaves in clear plastic bags for pick up on regularly scheduled bulk waste collection days. Homeowners in the City of Newport News can call the Newport News Fire Department's Smoke.
May 10, 2019. company offers trash pickup and recycling services in Newport News, VA. Solid Waste Collection Schedule & Calendar; Garbage Program.
Newport News Public. and normal Thursday trash, recycling and bulk collection will take place. Suffolk city offices will open on Thursday on a two-hour delay for Beta personnel. Virginia Beach city.
Newport News — Pickup scheduled for Thursday will take place Friday. Poquoson — Thursday's trash pickup is scheduled for Friday. Smithfield — There is no change to the refuse collection schedule.
Jul 11, 2018 · MNPD Padlocks Z-Mart on Lafayette Street and Neighboring Staffing Business as Public Nuisances. 7/11/2018. FOR IMMEDIATE RELEASE. After years of responding to thousands of calls at the Lafayette Street Z-Mart and a neighboring temporary staffing business, the MNPD today is declaring that enough is enough and the drain on the resources of the Hermitage Precinct has to stop.
Feb 18, 2018. Newport News — Full day for all students and staff. Poquoson — Full. Mathews County — Regular schedule. Middlesex County. Hampton —No recycling, refuse, bulk trash or yard waste collection on Monday. James City.
Carteret County operates the 12 Convenience Sites shown above to collect Solid Waste from the residents living in the unincorporated areas of the county as.
Check if your spelling is correct, or try removing filters. Remove quotes around phrases to match each word individually: "blue drop" will match less than blue drop. You can require or exclude terms using + and -: big +blue drop will require a match on blue while big blue.
Yard waste in all areas will be collected on scheduled pick-up days. Residents can search for their trash, recycling and/or yard waste days using on our online.
Dec 27, 2018. Newport News. Normal trash collection day; Trees can be left curbside or taken to the Virginia Beach Landfill and Resource Recovery Center.
1976 Rocky 1 Movie Memorabilia For Sale Guests will experience live mega-horror movies with this year's haunted houses, scare zones and roaming hordes. 6:30 p.m to 1 or 2 a.m. Ticket prices start. metaphysical stones and other items. Friday, May 10 Plant sale: 9 a.m. to 1. the movie's
QuickFacts UNITED STATES. QuickFacts provides statistics for all states and counties, and for cities and towns with a population of 5,000 or more.
Tidewater Fibre Corporation, doing business as TFC Recycling, offers waste collection, recycling. North Carolina and Chester and Newport News, Virginia.
2019 Solid Waste Collection Calendar. Newport News residents who pay the Solid Waste User Fee receive City solid waste services that include trash, recycling.
Breaking Cincinnati news, traffic, weather and local headlines from The Cincinnati Enquirer newspaper.
The Newport. will be no trash or recycling collection on Monday, May 30, due to the observance of Memorial Day. All collections for the week of May 30 will be delayed by one day. As a reminder,
SPECIAL FEATURES. The Prima Deshecha Landfill is a state-of-the-art, Class III municipal solid waste landfill. It features several environmental protection measures, including odor control systems, 5.7 acres of wetland, 175 acres of coastal sage scrub, 11 acres of riparian mitigation.
Residents of single family homes, townhouses, condominiums and mobile homes are charged a Solid Waste Fee, if they receive automated garbage collection.
To make trash pickup more efficient, the city is now sectioned into three trash zones, If you have not received a new recycling cart and would like one, please. on the holiday, your garbage will be picked up on the next regularly scheduled.
Dec 26, 2018. You could also use your Christmas tree as firewood to fuel a New. You do not need to schedule a bulk pickup during these two weeks. Trees will be picked up at curbside on regular trash collection day. Newport News.
Daily updates of everything that you need know about what is going on in the military community and abroad including military gear and equipment, breaking news, international news and more.
On May 14, the City Council unanimously approved the new electric scooter regulations, which will go into effect July 1. The new rules will decrease the allowable speed of electric scooters from 15 to 8 mph on the boardwalk, and to 3 mph in high-traffic areas with the use of geofencing technology.
Waste Management — Normal schedule. County Waste — Normal schedule. Newport News — No collection Monday, collections delayed one day the rest of the week. Poquoson — Normal schedule. Smithfield —.
Sep 11, 2018. WAVY TV 10 – Norfolk, VA NewsNexstar BroadcastingFREE – In Google Play. Man seriously hurt in early-morning shooting in Newport News.
Hire the Best Waste and Junk Removal Services in Newport News, VA on HomeAdvisor. Where do you need Junk or Trash Removal?. Pricing & Schedule.
With a new company in charge of garbage, some changes are coming to residents in Newport. The town board discussed. serves are every other week and using the same schedule everywhere makes.
In response to the United States Supreme Court decision, Reed v. Town of Gilbert, the City amended its temporary sign code regulations on Sept 10, 2018 to provide uniform sign criteria which regulate the size, height and placement of temporary signs within the City.
Newport News — Collections delayed one day throughout the week. Poquoson — Red recycling Friday will be picked up on Saturday. Williamsburg — Regular schedule York County — Collection normally.
The Newport. will be no trash or recycling collection on Monday, May 30, due to the observance of Memorial Day. All collections for the week of May 30 will be delayed by one day. As a reminder,
Nov 6, 2017. Trash Pickup and Recycling – City of Newport News. To see the pick-up days for your street, check out the city's pick-up schedule. Newport.
See which items we can collect and how to schedule a pickup. If there are fewer than three bags, they should be placed in the green trash cart. Brush, tree.
What To Get As A Souvenir From Vietnam Handmade Fenway Park Christmas Ornament Can I Get A Collection Account Removed The 87GB collection, which contained more than 12,000 files, has since been removed from Mega. the best thing you can do right now is go out and get one." We
Waste Management — No changes to schedule. County Waste — No changes to the schedule. Newport News — Schedule changing due to snow. Pickup regularly scheduled for Wednesday, Jan. 10, will be picked up.
Hampton: If Tuesday is a normal collection. of the week. Newport News: No pickup Tuesday, pickup delayed one day rest of the week. Poquoson: Blue recycling will be picked up Saturday. No bulk or.
Missouri Collectible Comic Book Dealers Search for collectibles dealers in your local area! We have over 4500 collectible dealers in our directory from across the United States. Whatever collectibles you're looking for, whether it's comic books, figurines, coins or memorabilia, our powerful search engine will help you
HRT — Sunday schedule on Thursday. will be delayed by one day. County Waste — Services will be delayed by one day. Newport News — Thursday pickup will take place Friday. Poquoson — Thursday.
Identifying A French Antique Doll Body item : description : 11839. recreational vehicle ford 1986 holiday rambler rv, vin #1fdke30lxhha43808, ford econoline 350, conversion by holiday rambler corp., aluma-lite xl, current odometer reading 41220, clean, has 2 front captain's chairs inside of rv, bed above cabin, fold-out sofa
Hampton — If Tuesday is your collection. week. Newport News — No pickup Tuesday, pickup delayed one day rest of the week. Poquoson — Red recycling will be picked up Saturday. No bulk or landscape.
The Iowa Habitat and Access Program has grown to over 20,000 acres, significantly increasing the amount of land available to hunters in Iowa. These opportunities are thanks to landowners who participate in the Iowa Hunting and Access (IHAP) program.
See a list of links related to garbage and recycling including your trash collection schedule.
Waste Management — Normal schedule. County Waste — Normal schedule. Newport News — No collection on Monday, Jan. 2. Collections delayed one day the rest of the week. Poquoson — Normal schedule.
If you are a teacher searching for educational material, please visit PBS LearningMedia for a wide range of free digital resources spanning preschool through 12th grade.
Trash/Recycle. 2019 Recycling Schedule: January – 9, 23. February – 6, 20. March – 6, 20. April – 3, 17. May – 1, 15, 30*. June – 12, 26. July – 10, 24.
Rains have flooded roads, caused schools to delay classes and prompted other schedule changes today. More closings may be available. The regular schedule for neighborhood trash pick-up will resume.
vote in office 05/17/19 the primary election is tuesday….and if you will be out of the county between six and six that day….you can still vote in the
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Garbage, Bulk Waste and Recycling Garbage is collected at curbside once each week from single family homes. For those residents served by the 18-gallon bin.
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The Sittaford Mystery is a work of detective fiction by British writer Agatha Christie, first published in the US by Dodd, Mead and Company in 1931 under the title of The Murder at Hazelmoor and in UK by the Collins Crime Club on 7 September of the same year under Christie's original title. It is the first Christie novel to be give…
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