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23.04.18 | Kerlink Added to Tech40 List of Best-Performing Tech SMEs Traded on Euronext Markets
THORIGNÉ FOUILLARD, France – April 23, 2018, 06:00 PM CET – Kerlink (ALKLK – FR0013156007), a specialist and global leader in solutions dedicated to the Internet of Things (IoT), has been included in the Tech40 label, which recognizes the best-performing tech SMEs on Euronext markets in Amsterdam, Brussels, Lisbon and Paris.
Listed companies are chosen by an independent group of European experts on the basis of their business, financial and stock market performance. Since 2015, the 75 companies that have been listed on the Tech40 have raised €2bn in capital increases, demonstrating their visibility and appeal among institutional investors. The growing role of the Tech40 label is reflected in investors' interest in the secondary markets, with Tech40 companies enjoying stronger liquidity upon joining the Tech40 index (+56 percent on average).
Kerlink has been listed on Euronext Growth Paris since May 2016 and was added to the EnterNext PEA-PME 150, an index of 150 fast-growing French SMEs, in 2017. In 2017, Kerlink Group generated revenues of nearly €25 million, and has posted average annual growth of more than 62 percent.
"The Tech40 is good company to be in, it validates not only the members' financial performance, the appeal of their publicly traded shares but also their business," said Robert Clapham, Deputy Chief Executive Officer. "Kerlink's broadening portfolio of IoT services, coupled with our industry-leading hardware, supports the company's goal of playing a growing role in implementing LoRaWANTM networks globally and bring the benefits of the Internet of Things to as many users as possible."


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Great fun was had by all!
Thank you everyone who attended our open day last Sunday.
The weather was great and we welcomed lots of lovely dogs (and owners!) who turned out to have a go at agility.
Visitors and their dogs were given a warm welcome into our training room where they got a chance to find out about the basics of agility and to watch a short slide-show.
If you missed it and would like to come along to have a go or watch one of our classes and meet the trainers please get in touch! Meg our agility trainer can be reached on 01582 794862 we hope to meet you soon!
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subset: commoncrawl


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Cuban Activists Facing Death Threats, Repeated Detention, and Physical AttacksAugust 13th, 2013 Theme: Cuba Libre!
Article from World Movement for Democracy
The Cuban government continues death treats and physical attacks agains the opposition. 12 members of the Las Damas de Blanco (Ladies in White) were lately arrested and beaten after attending church. Read the article
You can follow any responses to this entry through the RSS 2.0 Both comments and pings are currently closed.


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Air travel has officially made clear blue skies a thing of the past. It seems rare to look up these days without finding a crisscross of contrails outlining the solid blue. Even worse, scientists have found that contrails are contributing significantly to global warming by helping to trap infrared energy in the atmosphere.
But now researchers at the University of Reading think they have found a solution to both problems. They have shown that by adding a negligible distance to the length of flights, contrails can be significantly reduced and their impact on global warming lessened, reports the BBC.
Contrails, or vapor trails, are formed when planes fly through very cold, moist air and the exhausts from their engines condense. Some of them can be extremely long in length, stretching for nearly 100 miles. They can sometimes hang in the air for more than 24 hours before fully dissipating. Research has shown that the negative impact of contrails on global warming is even greater than a plane's carbon emissions.
It has long been known that contrails can be limited when planes fly at lower altitudes, but since this increases flying time, it also means burning significantly more fuel. But this leaves open a pressing question: Can the benefits of curbing contrails outweigh the negative impact of burning more fuel? The Reading researchers sought to calculate the answer.
Their study found that by simply re-routing flights in strategic ways, the increase in flight length required to significantly reduce contrails could be minor. For instance, avoiding a major contrail on a flight between New York and London would only add roughly 14 miles to the journey.
"You think that you have to do some really huge distance to avoid these contrails," said lead author Dr. Emma Irvine. "But because of the way the Earth curves, you can actually have quite small extra distances added onto the flight to avoid some really large contrails."
Of course, the precise adjustments required for flights to avoid generating long contrails will depend on the type of aircraft and the specific conditions present on the day of the flight, but these are easy factors to calculate.
"The key things you need to know are the temperature of the air and how moist it is, these are things we forecast at the moment, so the information is already in there," explained Irvine.
Although there are a number of legislative measures in place around the world to curb carbon emissions from aircraft, there are currently no measures in place aimed at reducing contrails. This, the Reading researchers claim, is something that needs to change. They hope that their study will help to provide some of the hows and whys such measures should be implemented.
Related on MNN:
- 9 ominous images of roll clouds
- 10 great green moments for planes, trains and automobiles
- 15 strangest things left behind on planes


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Jimmy Haslam III
Myles Garrett, helmet a 'weapon,' banned for rest of season
By Tom Withers Nov. 15, 2019 12:09 PM EST
Getting hot for Kitchens as Browns fail to reach potential
By Tom Withers Nov. 07, 2019 07:17 PM EST
Steelers owner Rooney to head compensation committee
Sep. 23, 2019 07:26 PM EDT
NEW YORK (AP) — Pittsburgh Steelers owner Art Rooney II will chair the NFL's compensation committee, which among other things negotiates the salary of top league...
Girlfriend of Browns DE Smith killed in roadside accident
By Tom Withers Sep. 11, 2019 02:06 PM EDT
Leading man: QB Baker Mayfield brings hope, hype to Browns
By Tom Withers Sep. 04, 2019 02:48 AM EDT
Browns owners donate $4.5 million to city's musical scene
By The Associated Press Aug. 22, 2019 02:53 PM EDT
CLEVELAND (AP) — Cleveland Browns owners Dee and Jimmy Haslam have donated $4.5 million to the city's eclectic musical arts. The couple has given to...
Browns Preview Capsule
By The Associated Press Aug. 22, 2019 12:02 PM EDT
NFL 2019: Browns not clowns, maybe title contenders
By Tom Withers Aug. 21, 2019 07:38 PM EDT
Browns' Kareem Hunt promises to 'lay low' after bar argument
By Tom Withers Aug. 05, 2019 04:08 PM EDT
Browns owners confident, optimistic about season
By Brian Dulik Jul. 28, 2019 03:16 PM EDT
Browns' Landry: Mayfield comments on Johnson a "non-issue"
By Tom Withers Jun. 14, 2019 12:15 PM EDT
Browns rookie Williams eager to learn from Beckham
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NFL draft headed to Cleveland in 2021, Kansas City in 2023
May. 22, 2019 05:22 PM EDT
KEY BISCAYNE, Fla. (AP) — The NFL's draft road show is headed to Cleveland and Kansas City. To celebrate the Browns' 75th anniversary, the 2021 draft...
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By Steven Wine May. 22, 2019 12:36 PM EDT
Green Bay Packers at Cleveland Browns 12/10/2017
Feb. 13, 2019 04:38 AM EST
AP Source: Browns hiring coordinator Kitchens as new coach
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Columbus Crew announce new president and head coach
Jan. 04, 2019 04:43 PM EST
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The Daily Herald (Brownsville, Tex.), Vol. 1, No. 27, Ed. 1, Wednesday, August 3, 1892
Description: Daily (except Sunday) newspaper from Brownsville, Texas that includes local, state and national news along with extensive advertising.
Date: August 3, 1892
Creator: Wheeler, Jesse O.
Item Type: Refine your search to only Newspaper
Partner: UNT Libraries


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September 16, 2013 by admin
24th SPREP MEETING (2013)
24th SPREP MEETING (2013)
16 SEPTEMBER, 2013Ministers
Members of SPREP
Members of the Diplomatic Corps
Director General of SPREP and SPREP staff
Ladies and gentlemen
It is a great pleasure to officially open this years' SPREP Meeting.
It has been 20 years since the signing of the SPREP Agreement which established SPREP as an independent regional organisation.
SPREP arrived soon after Cyclones Ofa and Val caused immense devastation to the islands of Samoa. It was a time of rebuilding and reconstruction for Samoa and a challenging time for us all.
20 years ago was also a time of building for SPREP. At that stage they were the newest and smallest regional organisation, having recently split off from the Secretariat of the Pacific Community – SPC.
There were a number of options for the location of SPREP within the region and the Government of Samoa at that time played a key role in ensuring that the decision was taken to move to Samoa.
This is a clear reflection of the importance placed by the Government of Samoa on the environment and on the importance of SPREP.
A well managed and healthy environment is a cornerstone of sustainable development and achieving the Millennium Development Goals in Samoa and for our Pacific peoples more generally.
Samoa recognizes the importance of this issue and we have developed many programmes to ensure a well managed and healthy environment, including the one million tree programme, improvement management of our waste and water, and taking practical steps to address the loss of important biodiversity.
As an example, by protecting the forests in the upper catchment area of Apia we are ensuring that people living in Apia will have a sustainable and clean supply of fresh water for now and for the future.
The last 20 years has seen environment becoming a more important issue and it has also seen a strengthening of the role and importance of SPREP.
When SPREP came here it had a small but dedicated staff. Since that time the organisation has grown to address a range of critical issues for the Pacific.
SPREP's programme now supports practical programmes in all Pacific countries, including on protecting biodiversity, reducing and better managing solid waste and hazardous material, and addressing the impacts of climate change.
SPREP is the lead agency in the Pacific region for climate change.
This is an issue of vital importance for me and for my fellow Pacific leaders. At our Forum Meeting two weeks ago we signed off on the Majuro Declaration for Climate Leadership.
This Declaration noted that climate change is the greatest threat to the livelihoods, security and well-being of the peoples of the Pacific and one of the greatest challenges for the entire world.
My Government recognizes that climate change is a reality, that it is an urgent issue and that we have to act now.
We are taking decisive action to adapt to climate change and to ensure an increasing part of our energy needs are met through renewable energy.
I applaud the decision by SPREP Members to develop the Pacific Climate Change Centre at SPREP.
This Centre will be a focus for innovation and climate leadership in this region and in the world. It has the full support of my Government and we have sent this proposal to the Government of Japan with the strong endorsement of the Government of Samoa.
Samoa and other Pacific island countries greatly appreciate commitments made under the Copenhagen Accord to provide 100 billion US dollars per annum by 2020 to support climate change efforts by developing countries. We also welcome the establishment of the Green Climate Fund.
However it is important that these commitments are matched by action.
I note the pace of disbursement has been very slow and we urge the international community to quickly and fully meet their pledges to help the nations of the Pacific – the most vulnerable countries on earth to the impacts of climate change.
SPREP has been at the forefront of efforts to address climate change in our region. The landmark PACC – Pacific Adaptation to Climate Change – project, developed jointly between SPREP and UNDP, is developing many practical programmes to address the impacts of climate change, including in sectors such as water, agriculture, and coastal zone management.
The increasing emphasis placed by SPREP and its members on protecting natural ecosystems as a key front line response to the effects of a changing climate is very positive. It must continue.
The close collaboration over recent years between SPREP and SPC to integrate regional and national efforts on climate change and disaster management is an important development for this region.
These areas cannot be considered in isolation. Better linkage between climate adaptation and disaster management is a vital step towards a more climate resilient Pacific.
I also congratulate SPREP on its many efforts to protect and better manage biodiversity – a critical issue given that our plant and animal species in the Pacific are being lost at alarming rates.
In Samoa we have partnered with SPREP on many programmes to protect and manage biodiversity including the removal of rats from the Aleipata islands and a major survey of biodiversity in the upland areas of Savaii.
Efforts to manage both solid and hazardous by SPREP and many partners, including the Japanese Government, through JICA, have also made a positive impact in our region.
Samoa has been pleased to trial the innovative Fukuoka method of solid waste management which is now being more widely applied in the region.
I note that SPREP has been undertaking an aggressive change management programme over the last few years and also that this is increasing the level of practical programmes and support provided to Pacific island countries.
We are seeing the benefits of this approach in Samoa.
I commend these activities and urge that they continue.
The Government of Samoa has been pleased to partner with SPREP on many programmes over the last 20 years.
But we must not rest on our laurels as the challenges ahead for our Pacific environment are many and varied.
I see from the papers for this meeting that you will have a very busy time ahead of you over the next 3 days.
I wish you all the best for a successful Meeting and for an enjoyable stay in Samoa.
It is now my pleasure to declare the Twenty Fourth SPREP Meeting officially open.


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If your desire for children has not yet come true, we would ask you to carefully read the following subjects. You'll find information that may help you to conceive a baby without medical help.
1. Recommendations for him and her
2. Nutrition guidelines
3. Intercourse
4. Nicotine
5. Environmental toxins
6. How to prevent congenital disorders
It is recommended to reduce your intake of carbohydrates and fats and instead eat a well-balanced diet rich in vitamins and proteins.
Carbohydrates (e.g. bread, pastries, sugar, flour, potatoes and so on) as well as fats (oil and butter for instance) should be consumed in moderate quantities only. This is especially important if you have a high BMI.
Alcohol, no matter whether it is beer, wine, must, cognac etc. should be consumed in small quantities only. If you are pregnant you should completely avoid drinking alcohol!
If you suffer or have suffered from a liver condition you should completely abstain from alcohol. Among the possible consequences of alcohol, tobacco and other toxins are decreased fetal growth, spontaneous abortion, genetic disorders and even an increased cancer risk for the baby (Fetal alcohol syndrome).
The possible consequences of environmental toxins (e.g. fumes or radiation at the workplace, plastic materials and many more) can be an underweight baby upon delivery, spontaneous miscarriages, genetic disorders and even a higher risk of cancer in children.
Studies have shown that the lung cancer rates in men, whose fathers were exposed to toxic fumes with chromium compounds such as welders, were increased. Therefore couples should stay away from chemicals and radiation (e.g. at your workplace) for at least 90 days prior to conception. This provides sufficient time for their sperm (spermiogenesis) and ova (oogenesis) to recreate.During pregnancy, too, you should do your best to avoid environmental toxics (such as plastic bottles etc.).


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gallery - The beauty innovations of summer 2018
As the mercury rises in the Northern hemisphere, beauty and skincare brands have got even more creative with a new generation of products and textures intended to seduce consumers this summer.
As the mercury rises in the Northern hemisphere, beauty and skincare brands have got even more creative with a new generation of products and textures intended to seduce consumers this summer.
Here is a selection of some of the best beauty Advent calendars to help make the wait until Christmas go faster.
Summer is already coming to an end in the Northern hemisphere and brands are presenting their new products and innovations to beauty fans. Here are some of the hottest launches for the new (...)
While suns creams and sun lotions remain a staple of the summer, lighter textures, which penetrate quickly without leaving white marks or glue-on effect on the skin, are on the rise. Dry oils, (...)
New skincare routines, new vegan mascaras and new mouth-watering beauty treats: there are plenty innovations for this month!
Here is a selection of hot beauty launches of the season: Khiel's, Lush Cosmetics, Summer Fridays, OGX, Wet n Wild, Sugar Rush.
Posts and ads for pink clay masks have taken social media by storm in the past few months. Here are five colourful skincare treats illustrating what has become something of a beauty trend of (...)
Firmenich is sponsoring the third edition of Corpo 35, the annual fragrance competition for the next generation of perfumers created by niche fragrance house Berry. During the opening ceremony at (...)
Back to the images on the 31st edition of Luxe Pack Monaco, which was held from the 1st the 3rd of October 2018 at the Grimaldi Forum. A very positive outcome, according to the organizers who (...)
After two days of intense business and networking, MakeUp in New York closed its doors with an increase of participants of 14%, compared to last year's event. The best edition to (...)
The Better with Less – Design Challenge, organised by Metsä Board, aimed to find new environmentally-friendly and functional packaging solutions for some of the world's most frequently used and (...)
Dubbed Clean Beauty in London the new trade show intends to gather experts, scientists, suppliers, brands, influencers and journalists under one roof "to build the future of clean beauty." Taking place on October 12 & 13, 2020 at The Brewery, located at 52 Chiswell Street at the heart of London, the event aims to encourage (...)read more
What about this country that has been struggling for years between natural disasters, less and less efficient politicians, poorly managed and inefficient international aid and the consequences for the fragrance industry? Without going back to the times of colonization, Haiti has suffered in recent years from several phenomena that (...)read more
The webinar is available on-demand until December 4th. Click here after to access it : http://webikeo.com/webinar/what-plastics-solutions-for-cosmetics-packaging-in-contact-with-formulas/ A market leader in thermoplastics, elastomers, finished parts and biobased polymers, (...)


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Update on move to Gmail: Cost-cutting measure a mix of sun and clouds
I checked in with early cloud adopter Jerry Hodge, CIO of Hamilton Beach Brands Inc., for an update on his pioneering migration from Lotus Notes to Gmail — the quintessential cloud app. The company, which started the project in January, is among the first ever to move to Gmail from Lotus, according to Hodge.
The backstory: Hamilton Beach was facing a mandatory upgrade of Lotus Notes that would have required not only the expense of the software upgrade, but also additional hardware and considerable staff effort. Hodge realized he could save about $500,000 in capital and operating costs over five years, and another $400,000 in labor if he went with the enterprise edition of Gmail.
In a year when his capital budget request was cut 60%, saving a million bucks seemed like a great idea, despite some trepidation on the part of his staff. He made the big switch the right way– gradually. He lined up a test group in the company's Mexico City and China offices to try it first to work out the kinks, and he smartly waited until everything was working before the C-suite got it. People's email would be maintained as @hamiltonbeach.com, which was important to the company.
So how did it go?
The good news is the move to Gmail came in ahead of schedule, on April 30, two months ahead of the June 30 deadline.
"Unheard of!," Hodge crowed in an email, giving kudos to his hardworking staff.
The bad news is there were a couple of hiccups. For example, at least half the attachments in some parts of the company email did not get transferred in the move to Gmail. After running the email through the transition process two times, IT got most of them. The other wrinkle was people's contacts lists — Hodge's staff had to do the lists by hand mostly to get them over.
"Our best success was achieved when exporting contacts to a CSV format and importing them into Google — but they had to be done one by one," Hodge reported.
His biggest headache, in retrospect?
"I would have to go with the repeatability/consistency of the automated migration tools. We knew up front that we were one of the 'early adopters' for migrating from Lotus Notes to Google. We were patient, but still frustrated," Hodge said, but added this comes with the territory of being an early adopter.


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Current Location:United StatesChange Location
United States
Home > News > Fourth Quarter for Mid-Atlantic Tempered by Uncertainty
Cushman & Wakefield today released fourth quarter 2012 statistics for the Washington, D.C. Metro area, detailing a real estate market characterized by a cautious and conservative watch-and-wait mood.
The looming fiscal cliff - only part of which was averted as it related to tax cuts - as well as sequestration and the debt ceiling worked together to dampen activity throughout the region.
Here's a look at the four areas:
The District
In the District, the office market contracted, posting negative absorption and increasing vacancy rates.
"This was due mainly to both government and private sector tenants' drive to achieve efficiencies," said Paula Munger, Regional Research Director of the Mid-Atlantic and Southeast for Cushman & Wakefield. "Organizations are looking for economies everywhere, and that translates into occupying less space."
Leasing activity, however, increased over last year's level as several large law firms committed to space in projects under construction or still-to-be developed.
Northern Virginia
In Northern Virginia, office market indicators weakened further with total negative absorption of 2.5 million square feet, the vast majority of which was due to government agencies vacating space in Crystal City and the RB Corridor as dictated by BRAC. Like the District, new construction is attracting tenants both inside and outside the Beltway.
Suburban Maryland
The Suburban Maryland office market was also characterized by negative absorption of space, increasing vacancy rates, and lackluster leasing activity. In fact, the area saw the highest percentage of renewal activity, accounting for nearly 60 percent of all transactions closed.
Markets outside of the Central Business District continued to outperform Baltimore's Downtown. The Fort Meade district posted the highest positive absorption of all submarkets at 202,780 square feet, driven by government contractor demand, particularly those firms engaged in high-tech services such as cyber-security and cloud computing.
In the investment market, total 2012 sales volume in the D.C. Metro area fell to $5.6 billion from $7.5 billion in 2011. While some investors took a step back from Washington in 2012 due to weakening office market fundamentals, sales volumes in the District were off by only 5 percent, compared to a 48 percent decrease in the suburbs. The year 2013 will bring some good opportunities for investors who can wait for much healthier fundamentals.
"Our research does reveal a few bright spots, including new construction as well as continuing opportunities for investors willing to wait two to three years for a return," said Brian Dawson, head of Cushman & Wakefield operations in the Washington region. "We think 2013 will end some of the uncertainty and stabilize the marketplace, leading to a dynamic 2014."
Dallas, TX
Phone +1 972 663-9624
Contact me


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Bellafill Acne Scar Before and After Photos
Not all areas were filled. Treated areas are circled.
About BellaFill
If you would like to learn more about BellaFill and if it is the right treatment for you, please call our office at 949.727.3800 today to schedule a consultation or fill out the form on this page and one of our trusted staff members will reach out to you promptly.
*Images courtesy of Suneva


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Events for Wednesday, October 30, 2019 › Children & Family
Events Search and Views Navigation
10:00 am
North End Farmers' Market
This market was launched in 2008 by Hartford Food System as the only market in the city to operate north of the downtown area. The market represents a grassroots victory for North End residents who long desired a farmers' market in their community. Every summer the market brings fresh, locally grown fruits and vegetables from […]Find out more »


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Is there justice in the gutter? All depends on who defines it. And how.
Justice by Jack Strange
My trial comes up next week and I could be facing a life sentence. My son's dead worried about it, but I'm not. I can't wait to see that bastard Sykes in court testifying against me, telling the world what I did to him. I can't wait to see the look on his face when it's over and he realises what I've done.
I'm a retired businessman. I shouldn't have got drawn into committing a crime at my age, but when my grandson died, I had no choice. He was only four years old.
The wife was in bits, and as for my son, Alan, and my daughter-in-law, Beth, they'll never get over it.
Have you ever seen a child's coffin? They're so tiny. It breaks your heart, it really does.
It was how little Eddie died that got to me as much as anything.
He was riding his tricycle when a truck came up the road and took the corner too tight. The rear wheel mounted the pavement and ran over my little Eddie. He banged his head when he fell and never recovered.
People who saw the accident said the driver – Harry Sykes - laughed when he realised what he'd done.
He got prosecuted for it, and said he was sorry, but it was just an act. He might've pulled the wool over the judge's eyes, but not mine. I knew he was saying it just to get off – and it worked.
The prosecution charged Sykes with causing death by careless driving. It should've been murder, if you ask me.
It was his first offence, so he got a suspended sentence and walked out of court a free man.
What kind of justice is that?
He ought to have been banged up for years.
So I decided to do something about it.
I had a word with the wife. We agreed I should take the law into my own hands.
But I didn't discuss it with my son. He wouldn't have understood. Alan is a very different person to me. I've had to claw my way up from the gutter to get on in life, and he's had all the privileges you can get from day one.
When he was growing up, I put an expensive roof over his head, made sure he had good food to eat, and paid for him to have the best education going. He went to university and became a successful lawyer. He doesn't know anything about the sacrifices I've had to make on his behalf. I gave up everything for my family, including a few scruples along the way.
Once I'd decided to do something about Eddie's death, I went out and bought a gun. A .38 snub nose revolver, a real Saturday night special.
Then I confronted Sykes in the street. He was with his girlfriend. He was a right coward. He grabbed her and used her as a shield.
I stuck my arm straight out with the gun in it and walked up close to him.
"Be a man," I said, holding it against his temple.
But he cowered like a frightened little girl, got to his knees, and begged for mercy.
"Please, I don't know why you're doing this, let me live," he said.
"It's for my grandson, Eddie. The little boy you killed. Remember him?"
I crouched down, put the muzzle to his thigh, and pulled the trigger.
There was a deafening noise as the gun went off.
The bullet shattered his thighbone.
When I pulled the gun away there was a big hole in the side of his leg with wisps of smoke coming out of it.
Very nasty.
His girlfriend screamed and he screamed even louder.
"Serves you right you cunt," I told him.
I turned to his girlfriend.
"Sorry about that, love," I said. "I didn't mean to drag you into this, but I had no choice. If he was half a man, he wouldn't have used you as a shield, and you wouldn't have had to see this. You ought to finish with him. You've seen what he's like. He's no good."
I put the gun in my waistband and walked away.
It wasn't long before the coppers came round to my gaff and arrested me.
They charged me with causing Grievous Bodily Harm. The sentence for that is almost as bad as that for murder. So in some ways, I might as well have killed Sykes. But I wanted him to live, to feel the pain I felt.
I didn't deny the charge. How could I? I did it in broad daylight on the high street. Lots of people saw me, and it was recorded on video.
It's been hard on my son, of course.
"Dad, how could you?" he said. "Why did you take the law into your own hands? You should know better than that. You used to be a respected businessman. I've lost Eddie, and now I'm going to lose you. You'll be locked up for this."
"Sorry, son," I said. "Don't worry. I'll get a good brief. He'll get me off."
"You don't know what you're talking about. It's an open and shut case. You'll get sent down for years."
"Suppose you're right," I said.
But I knew he wasn't.
You see, my line of business was extortion and racketeering. I was very good at it.
And by the time my mates get through with the jury, they'll be awarding me a medal, never mind letting me off.


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You are here
Your Local Guide
Hello there,
My name is Gino. I was born and brought up in Belarus, which is known for its rich culture, creative arts and architecture. While in Belarus, I was mainly working on fixing cars. When I was not fixing cars, I was riding my bike exploring the beautiful City. I moved to San Francisco in 1995 and started working as a press operator. From 1998-2015 I worked as a Limo driver. Although I loved working as a Limo driver, I was exploring other opportunities in the Bay Area that were more fun and allowed me to be around people and share my love and knowledge of my beautiful city and that's how I landed at Extranomical Tours in 2015. Everyday has been exciting here and I love sharing my passion with my guests. While I am not working, I am most likely traveling with my family in my car, as I love driving. I love long distance biking and kayaking in large bodies of water. Someday I'd like to travel to Alaska and British Columbia. I am looking forward to having you on the tour.
Trip Guided by Gino
- 1) San Francisco Opera House – One of the world's leading opera companies for more than 90 years. Company established in 1923. Each year a lot of famous artists from all over the world coming to San Francisco to perform on the stage. The Opera house is also home to San Francisco Ballet. It is now one of the most beautiful buildings in San Francisco inside and outside.
- 2) Ferry Building Marketplace – This building is located in the central of the city and has been since 1898. The Clock tower is an icon of the San Francisco waterfront. It reopened in 2003 after a 4 years restoration. It also has a world class public food market.
- 3) Bluegrass Jazz Festival in Golden Gate Park (2016: September 30 – October 2) – a free performance for over 100 musical artists on 7 stages. A fantastic festival that happens every year in the same place around the same time.
- 4) Wine auction in Napa Valley - Every year in the first week of June: An auction filled with a variety of wines from different vineyards and also tasty food (with recipes you can get) from California's artful cuisine including great performances.
- 5) Ghirardelli square: Ice cream, wine and food. And most importantly - the views. Ghirardelli Chocolate Company hosts the annual Chocolate Festival every September – a two day celebration of CHOCOLATE with live music, chef demonstrations, ice cream eating contests and much more.
- 6) Take a ferry to anywhere – You have lots of options: Sausalito, Alcatraz Island, Angel Island, etc. San Francisco Bay is one of the most beautiful places in America. Most locals don't even get there.
- 7) Golden Gate Bridge – You can go walking or kayaking under the bridge. I prefer kayaking. There is scenery including the waves of Pacific Ocean views and another site where there are no waves in the bay.
- 8) Walk down the pier in Pacifica – It is only 10 miles from city and a totally different view of the open ocean. The pier opened on November 1st , 1973. It is 40 feet long in the shape of an "L" and it is one of the most famous fishing and crabbing places for Bay Area locals. In the summer and early fall you can see whales if you're lucky.
- 9) Twin Peaks - One of the best views in the city in the center of San Francisco. On a clear day you can see downtown of San Francisco, Golden Gate Park, all the bridges, Oakland, Berkley and the bay. You can also walk to the North Peak (Eureka Peak). You able to reach it by car, bike, or on foot.
- 10) Wine Country - Just get there, check out the wineries – there are more than 1700 of them in Napa and Sonoma! Tour a winery and learn about wine making. Every winery seems to have a slightly different way of doing it. All are interesting and hey, you get to drink wine whilst learning something new. It is a great experience.


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That's the age old adage that many people are aware of, but rarely ever include in their plans to achieve their goals. In moving forward here at Bam Creative, a great deal of our focus has become digital strategy. Websites and email addresses are now as common place as a phone or fax number on each and every company's business card. But what helps make a good website great? Knowing your target.
A/B testing (also called split testing) is one way of achieving that goal, it places one approach against another. Only by trying different techniques and approaches can we evolve (or in this case your digital presence). Recently I have been involved in both email and website split testing and found results to be both interesting and varied.
If you're reading this post and you are a client of ours you may or may not be familiar with BamMAIL. A/B campaigns are just one of its awesome tools. Generally speaking getting high open and click rates are the goals of a good email campaign. With A/B testing we can test content and design changes, and see the impact they have on opens or goals, such as clicks or replies.
We've experienced a growth in the number of opens and clicks over time by fine tuning a number of these factors, either on their own or together. We've learnt a number of tricks with content, such as the sender email address, various subject lines and even altering the arrangement of the content that is presented in the email, that can have a profound effect on the final results of an email.
With more people using email then the web, you'd be silly not to give it a try and get your message even further. Further facts you may find interesting include:
- Including the word "exclusive" in email promotional campaigns increases boosts unique open rates by 14% (Experian).
- B2B emails with 1 or 2 words in their subject lines are opened at a higher rate than those with more (Yesware)
- Too many emails (69%) and content that is no longer relevant (56%) are the top reasons people unsubscribe from emails (Chadwick Martin Bailey).
But what about websites I hear you say? Let's concentrate on two variables, design and content. We've run such testing on client sites (as well as our own), using BamCMS. Firstly, we setup pages accessible only by URL and emailed test groups the current versus proposed content/design updates. In cooperation with other reporting tools such as heat maps and analytics we can paint a clear picture of just how successful your website can be.
Don't you think it's time to begin working smarter and not harder? Get in touch and we'll have your website and email doing just that.
- Dean Robbins, Designer, Bam Creative.


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My Frierian roots and recent research (Glickman, 2002) have led me to believe that collegial leadership should be the goal. More stakeholders should be brought into decision making process so that those decisions are carried out with fidelity. However, I think I have assumed that a collegial school requires a principal who thinks and acts collegial at all times. After more discussion in class, however, I am not sure that this assumption will bear out once I get down to the hard work of leading a school.
I was really moved by Dr. Z's story of the algebra teacher who said what she really needed was a lesson plan so she could just go home. I'm not sure what I would do in that situation. In the course of this class, I've really owned what it means to me to operate as a big picture thinker. I've been able to be more gentle with myself as I struggle with administrative tasks at school because I can see the absurdity of being asked to support the social and emotional development of 124 teenagers. By thinking about the big picture, I am able to celebrate my victories rather than beat myself up for not being able to do all of the work I want to do in a deeply flawed system, and I'm able to prioritize tasks based on what will have the most long-term positive effects for my students.
So, I think it might be hard for me to get down into the weeds. Not only have I never taught math, I just don't know if I'm ready to respond to a teacher in the scenario above with just a lesson. I want to discuss what in her day-to-day work is causing this feeling of being overwhelmed. What can be juggled more efficiently? What can be discarded in favor of mental health and excellent first instruction?
Rather than thinking of my administrative style existing on a continuum between directive and collegial action, I want to start thinking about a particular approach for a particular moment.
I also want to commemorate this chart we worked on in class tonight to remember that it's about the right style for the situation rather than forcing a situation to fit my preferred style.
Skill building
Partnership building
Capacity building
Leader's Role
Teacher's Role


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Using the new sensor and location API from Silverlight 4
Play Using the new sensor and location API from Silverlight 4
by Michel Baladi, Matchride.net.
In this screen cast you will get a short introduction to the new sensor and location API's in Windows 7 and how to use these API's from Visual Studio 2010 with .NET framework 4.0 as well as from Silverlight 4 using COM interop from Silverlight's the new out-of-browser (OOB) application model. You will also get brief information on developing a sensor for Windows 7 and a link from where you can download a free ready-to-use sensor that can translate your IP address to a geographical location (latitude/longitude).
Right click to download this episode
- Low Quality MP4 (24.8 MB)
- Mid Quality WMV (27.9 MB)
More episodes in this series
Code Contracts and Pex: Power Charge Your Assertions and Unit Tests
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The Discussion
Thanks for covering this, especially the Silverlight access, and the I.P. to Lat./Long sensor looks really interesting!


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People are opting for their remains to be used in building artificial reefs
People are opting for their final wish to be their remains are included in an artificial reef. The Neptune Memorial Reef is an artificial reef located 3.25 miles off Key Biscayne in the Florida Keys. The 16-acre memorial reef is situated in 45-fee of water and features the remains of people wishing a more environmentally friendly and ocean centric burial.
Read the full article here.


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Dave Rennie has made one major decision surrounding his coaching future and the next will arrive in three years' time.
The coach will follow his final season in charge of the Chiefs with a move to Glasgow in 2018, signing a two-year contract with the Scottish club to leave open the possibility of ascending to the All Blacks job after the next World Cup.
Much has to go right for that to become an eventuality. Steve Hansen, for one, will have to determine that two World Cup cycles are enough, while Rennie will need to beat out a number of other highly qualified candidates.
But his Glaswegian stint will only aid Rennie's quest to become the next All Blacks coach - if that's the path he decides to pursue.
"Coaching the All Blacks would be great but it's a tough gig to get and who knows how long Steve will hang around?" Rennie told Newstalk ZB.
"He's doing a great job and if they win another World Cup he may stick around longer.
"I've always talked about going overseas and having the chance to immerse ourselves in a different country. We'll see what happens beyond that. I only went to Manawatu for 18 weeks and ended up being there for six years, so who knows?"
Rennie has more immediate focuses before casting his attention too far in the future. He will want to finish his Chiefs tenure the way it began - with a Super Rugby title - and then establish a similar legacy in Scotland.
Given his credentials and intention to travel, Rennie would have been in hot demand among European clubs. He was reluctant to name names but said Glasgow's collective character and their lofty aims were what lured him.
"What I liked about Glasgow was they were really good people and I think they're really straight shooters," he said. "I like what they're trying to do - it's a really aspirational club." It's a club where Rennie will be dealing with a reduction in player depth, compared with the production line available to him in New Zealand, but he is confident he will be able to build a quality squad.
That may include enticing a few Kiwis to join him in the Pro 12 and having previously established a relationship with current Glasgow coach Gregor Townsend, who is set to replace Vern Cotter at Scotland, Rennie will look to sign some new recruits before he arrives.
He has in his contract the option of a third year with Glasgow, which is when decision time will arrive. But, before then, it will be the Chiefs who have to make up their minds on a replacement.
Ireland coach Joe Schmidt is heading home and looking for Super Rugby work, so will be considered a favourite. Current assistant Kieran Keane will surely be deserving of an elevation, while Cotter may complete the coaching merry-go-round and link up with the Chiefs.
"He's a very good man, Vern, and has a hell of a coaching pedigree," Rennie said. "If he decides to come home he'd be a strong candidate, no doubt."


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What is Slime Rancher?
Slime Rancher is the tale of Beatrix LeBeau, a plucky, young rancher who sets out for a life a thousand light years away from Earth on the 'Far, Far Range' where she tries her hand at making a living wrangling slimes.
With a can-do attitude, plenty of grit, and her trusty vacpack, Beatrix attempts to stake a claim, amass a fortune, and avoid the continual peril that looms from the rolling, jiggling avalanche of slimes around every corner.
Sounds great! Give me more details!
Slime Rancher is a first-person, sandbox experience where players will solve problems and survive through mastery of their vacpack: a vacuum/cannon/backpack that can vacuum up and blast out anything that isn't nailed to the ground.
Each day will present new challenges to players as they attempt to amass a great fortune in the business of slime ranching.


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(Reuters) - Goldman Sachs Group Inc (GS.N) will sell its power plant development unit to Carlyle Group (CG.O) in the latest of a string of deals by the private equity firm since the break-up of its energy investment venture with Riverstone Holdings LLC.
The deal to buy Charlotte, North Carolina-based Cogentrix Energy LLC will give Carlyle access to three coal-fired and two solar power plants, and a development pipeline with over 550 megawatts (MW) of operational capacity.
The terms of the deal, expected to close in the fourth quarter, were not disclosed.
Goldman Sachs, which bought Cogentrix in 2003 for $115 million and assumed $2.3 billion of debt, will retain a minority stake in one of the power plants. The decision to divest it now was purely commercial, a bank spokesman said.
"After nearly 10 years of ownership, we decided the best way to maximize the remaining value of the assets and to preserve the platform was through a sales process," he said.
But the sale, carried out through a months-long auction this year, also comes at a time when major Wall Street banks are engaged in a high-stakes debate with the Federal Reserve over whether they should be allowed to continue to own and operate major pieces of energy and commodity market infrastructure.
Under existing rules, regulated banks are barred from buying and operating physical assets, although many have been permitted to engage in active trading of physical commodities. Owning the infrastructure can often boost trading profits.
But a previous amendment to banking regulations offered an apparent exemption that would apply to banks that later converted to regulated holding companies, as Goldman and Morgan Stanley (MS.N) did in 2008. The Federal Reserve gave Morgan Stanley, which also owns power generation assets, up to five years from that date to comply with rules.
Even after the sale, Goldman will have sizeable commodity sector investment. It shows no signs of moving to sell U.S. metals warehousing firm Metro International, which it bought in 2010, and earlier this year, it paid more than $400 million to buy Colombian coal mine assets from Brazil's Vale.
The acquisition of Cogentrix is Carlyle's second in the energy sector in as many months. In July it struck a deal with Sunoco Inc (SUN.N) to save and expand the largest U.S. East Coast refinery based in Philadelphia to capitalize on the nation's shale boom.
Carlyle, the world's No. 2 alternative asset manager, will use Cogentrix team's expertise for future investment in the power sector and to acquire and develop conventional and renewable power projects across the United States, Carlyle Chairman Daniel D'Aniello said in a statement.
Cogentrix, started in 1983, has developed electric power generating and co-generating facilities throughout the United States with a combined generating capability of over 5,000 MW of electric power.
In an effort to peg a value on the deal, power traders said they were looking at Exelon's sale last month of three coal-fired power plants in Maryland for $400 million. With a total capacity of 2,648 MW, the deal came out to an average of around $150,000 per megawatt.
At that rate, the Cogentrix deal would come to some $82.5 million, although it may have commanded a premium to that rate since some of the Cogentrix plants were newer than Exelon's and included some solar power facilities.
Vinson & Elkins was legal adviser to Carlyle on the transaction.
Reporting by Thyagaraju Adinarayan, Sunayan Bhattacharjee and Jochelle Mendonca in Bangalore, additional reporting by Scott diSavino and Jonathan Leff in New York; Editing by Saumyadeb Chakrabarty and Bernadette Baum


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So, my dear brothers and sisters, be strong and immovable. Always work enthusiastically for the Lord, for you know that nothing you do for the Lord is ever useless.
1 Corinthians 15:58
While at work today, I noticed a single plant growing wild in an area of sandy clay.
Its solitary condition made me take notice–so much so that I decided to photograph it.
If I were a single grass plant, I would probably hope to be among a group of plants in rich, fertile soil.
Standing alone in rusty coloured clay would certainly not be my station of choice.
There have been times, however, that I have felt separated and alone in a less than desirable environment in which to thrive.
Even so, my intentions still should have been to live my life for the Lord, doing those things that pleased him.
I must always remember that nothing I do for the Lord is ever useless.


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Radio Manav Rachna 107.8 celebrates its 8th Foundation Day with enthusiasm, launches Swachh Faridabad Swachh Bharat
Radio Manav Rachna 107.8 celebrated its 8th Foundation Day with lot of enthusiasm. The occasion also saw the launch of initiative by the Manav Rachna fraternity and RMR – "Swachh Faridabad, Swachh Bharat" in association with Faridabad Industries Association (FIA) and Municipal Corporation Faridabad (MCF).
Following the footsteps of Founding Father Shri O.P. Bhalla, Manav Rachna has always tried its bit to contribute to the society. The initiative, Swachh Faridabad Swachh Bharat brought many organisations under one umbrella which are striving hard to make Faridabad clean.
Remembering the visionary Dr. O.P. Bhalla, Dr. Prashant Bhalla said that his father always believed in community service and the unity that the community has. Hence, Radio Manav Rachna was born in 2009. And RMR 107.8 is one such Community Radio which has bought the community together. It also went on to become the first Community Radio of Faridabad. He congratulated the entire Radio Manav Rachna Team and wished them success and believed that RMR would see new heights in the coming years.
Seconding his thoughts, Chief Guest for the Day Ms. Sonal Goel, IAS, MCF Commissioner, Faridabad said that though she never got a chance to meet the legend but came to know about his dedication to serve people through his work and the people who he had worked with. She said, "RMR 107.8 FM is a great platform for creating campaigns like Swachh Faridabad Swachh Bharat."
She also said the Municipal Corporation of Faridabad is proud to be the part of such initiative launched by RMR 107.8FM, and will always extend its support for such noble causes. She also said that SMART City tag is a big responsibility and citizens should contribute to keep it clean. It's a collective effort and they
The organizations, which have come together under the initiative Swachh Faridabad Swachh Bharat include Faridabad Industries Association, Dr. O.P. Bhalla Foundation, Faridabad Action Group, Rotary Club, Sector 21 D, Smart City, Human Kind Foundation, Sledge Hammer Foundation and the Government Senior Secondary School.
The Foundation Day also honored its community members for their selfless service and share their happiness and grievances through RMR 107.8. The community members include Dr. M.M Kathuria, Mr. D.C Chaudhary, Prof. D.P Bhanot, Ms. Kamini Singh, Ms. Chandana Kapoor, Ms. Sandeep Kaur, Dr. Leena Sinha, Ms. Manju Chandila, Mr. Ramesh Chandna, Mr. Shailendra Nangia, Mr. Pradeep Garg, Mr. A.K Mittal, Ms. Jatinder Kaur Ruby and Mr. Sachin Gaind.
The Foundation Day also saw the launch of much awaited musical CD of Dr. MM Kathuria. The album – Samarpan inspires everyone to lead life with full zest. The lyrics were composed by Dr. M.M Kathuria and Ms. Chandna Kapoor. The album was released by Dr. Prashant Bhalla, President MREI, Dr. N.C. Wadhwa, Vice Chancellor, Manav Rachna International University, Col. Kapoor, FIA, Dr. Neemo Dhar, Dean FMEH and other senior dignitaries.
The occasion was graced by Dr. Prashant Bhalla, President, MREI; Dr. N.C Wadhwa, Vice Chancellor MRIU; Col. Kapoor Faridabad Industries Association; Dr. Neemo Dhar, Dean, FMeH, Ms. Shailja Naqvi, Deputy Director, RMR; Ms. Sanyogita Sharma, Principal, MRIS Charmwood and senior faculty members.


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Has Been Spotted Wearing these Sunglasses
Stefani Joanne Angelina Germonotta, a.k.a. Lady GaGa, got her nickname from music producer Rob Fusari, who believed that her vocal style was similar to that of Queen frontman Freddie Mercury. He dubbed her "GaGa" after the band's 1984 song, Radio Ga Ga, and she later chose to use that as part of her official stage name.
Lady GaGa was born March 28th, 1985 in Yonkers, New York and attended a private Catholic school. She began playing piano at the age of four and was writing piano music by the time she was 13. The following year she began performing for open mic nights around New York City. She began attending the Tisch School of Arts at New York University at age 17, but eventually withdrew to focus on her career. In 2004, she was performing around the city and working as a songwriter at Interscope Records. It was there that she developed the industry contacts to get her first big break.
She moved to Los Angeles in 2008 to finish her first album, The Fame, which debuted in late October. The album received critical acclaim and the first three singles from the album, Just Dance, Poker Face, and LoveGame all became number one billboard hits. At the same time her album was released, Lady GaGa began touring as an opening act with New Kids on The Block to help them promote the release of their new album. She then began a tour of her own, The Fame Ball Tour, in the first quarter of 2009. In late 2009, she was supposed to begin touring with rapper Kanye West, but after his intoxicated rampage at the MTV Video Music Awards, that was canceled. Instead, began touring solo in November 2009.
Lady GaGa's single, Just Dance, was nominated for Best Dance Recording at the 2009 Grammys. She also received a total of nine nominations for the 2009 MTV Video Music Awards, winning Best New Artist while her single, Paparazzi, won two awards: Best Art Direction and Best Special Effects. She continues to grow professionally and has used her influence to speak out on the issue of gay rights. She joined in the National Equality March on Washington D.C. on October 11, 2009.


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VRV is a commercially applied heating and cooling system that distributes refrigerant rather than water, to multiple fan coil units serving the conditioned spaces. The natural attributes of a VRV system position it as an alternative to a chiller system.
Daikin's current VRV system is the 7th iteration of the first VRV launched in 1982. Completely re-engineered to realize opportunities for VRV in taller / larger buildings, it utilizes the latest advances in refrigeration and air-conditioning technology. The totally new Daikin Inverter compressor system delivers improved efficiency and performance, while ensuring satisfaction of demands throughout connected zones across the complete operation cycle. With a choice of Heat Pump 460V/3Ph/60Hz or 208-230V/3Ph/60Hz, the system configurations power up to 30-tons in capacity from a single piping network. The system also allows up to 62 indoor fan coil units, a 200% connection index, ventilation options and integrated controls, with BMS options and piping limitations never before seen with a DX system. With these attributes, VRV naturally positions itself wherever the attributes of a traditional chilled water systems are desired
Commercial sites can range in size from a few hundred to several thousand square feet. That's why Daikin offers the new VRVIII air cooled system with advanced features to meet practically any challenge. Completely re-engineered to realize opportunities for VRV in taller, larger buildings, it utilizes the latest advances in refrigeration and air-conditioning technology.
These systems are designed for business applications where a single VRV outdoor unit can serve up to 58 independent zones. VRV offers superior flexibility and energy efficiency, in an easy to install packages. Choose from the VRVIII-S, VRVIII Heat Pump or the VRVIII Heat Recovery System
It is widely used worldwide in applications such as: Health care, Hotels and conference facilities, Offices, Residential multi-family, Restaurants, Retail and Schools.
- Energy efficient, all systems incorporate inverter "variable speed" compressors
- Many zones (individual control – up to 62 zones on one piping network)
- Centralized system (long piping – up to 3,280 ft. total)
- Tight temperature control (proportional integral derivative)
- Large capacity (modular systems combination)
- Quiet operation (down to 25dB(A) indoor)
- High level control (BACnet, LonWorks, Intelligent Manager, Intelligent Touch controller)
- Superior heating performance
- Absolute Comfort
Why is VRV an efficient alternative? The heating and cooling system in a commercial building is used at 70% or less of its maximum capacity for 755 of the operational time. To find out more about the VRVIII system, Ask An Expert.


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Recent Posts
- David McEown's new website.
- Arctic 2016, New Blog and Website.
- New Website, Upcoming Antarctic Travels
- Hollyhock Watercolour Workshop
- Antarctica, South Georgia and the Falkland Islands 2013 painting highlights.
- McMichael Canadian Art Collection "Art Mentorship Project"
- The Northwest Passage
- Painting In The Great Bear Rainforest
- 2012 Whistler and Gibsons Summer Workshops
- Pacific Spirit Forest Series
Art Links
Tag Archives: art mentorship
McMichael Canadian Art Collection "Art Mentorship Project"
December 20, 2013 – March 02, 2014 Exhibition Opening Sunday, January 19, 1:00 to 3:00 pm, with remarks at 2:00 pm McMichael Canadian Art Collection 10365 Islington Avenue, Kleinburg, Ontario, Canada L0J 1C0 (Islington Avenue north of Major … Continue reading
Posted in Algoma, Antarctica, Arctic, Art Workshops, en plein air, Lake Superior, Landscape painting, McMichael Canadian Art Collection, North Pole, Northern Landscapes, Watercolour Tagged art mentorship, Ben Barak, en plein air, Group of Seven, Humber Valley, McMichael Canadian Art Collection, north pole, Tom Thomson Shack, Trilliums, watercolour, watercolour techniques, York Region Arts Council 2 Comments


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D. ADU, M.D.; C. J. LOTE, Ph.D.; J. MICHAEL, F.R.C.P.; J. H. TURNEY, M.R.C.P.; P. MCMASTER, F.R.C.S.
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To the editor: Cyclosporine and its nephrotoxicity have recently been reviewed in your journal (1). Subsequently, Dr. Duarte (2) asked whether the nephrotoxicity of cyclosporine might result from an effect on prostaglandin metabolism.
We have recently suggested that the nephrotoxicity, hypertension, hyperkalaemia, and haemolytic-uraemic syndrome seen in some patients given cyclosporine therapy could be explained if this drug inhibited renal prostaglandin synthesis (3). We studied urine prostaglandin E2 excretion in female renal allograft recipients treated with either prednisolone and azathioprine (11 patients) or prednisolone and cyclosporine (14 patients). The mean urinary prostaglandin E2 excretion in patients given prednisolone and cyclosporine
ADU D, LOTE CJ, MICHAEL J, et al. Cyclosporine and Prostaglandins. Ann Intern Med. 1985;103:303. doi: https://doi.org/10.7326/0003-4819-103-2-303_1
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Published: Ann Intern Med. 1985;103(2):303.
Copyright © 2019 American College of Physicians. All Rights Reserved.
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Summer is in full swing and I am headed outside every chance I get. With our long summer days, I spend a little longer out walking the dog in the evenings and my kids are constantly asking if we can get out and ride our bikes in the neighborhood or, better yet, on the local trails.
I admit, when I am driving home from work, I sometimes do not give much thought to road safety. Yes, I pay attention to the road, drive the speed limit, and slow down for playground zones, but otherwise I am just enjoying the warm sunshine filtering through my sunroof as I drive along, feeling safe and enclosed in my car.
When I'm walking the dog with a couple of children who are blissfully unaware of potential hazards, though, I find myself acutely aware of road safety. I keep an ear open for an approaching car and am checking each driveway to ensure there is no one about to back out. People who walk, jog, and ride their bikes are road users. Vulnerable road users. Even people who ride motorcycles are considered vulnerable because they do not have an enclosed vehicle for protection. In Northern Health, people who ride motorcycles and those who choose to walk are at the most risk for hospitalization or even death in the event of a crash with a vehicle.
I learned several interesting facts in the Provincial Medical Health Officer's report: Where the Rubber Meets the Road.
Did you know?
- A person walking has a 90% chance of surviving a crash with a car if the car is driving 30 km/hr.
- A person walking has a 20% chance of surviving a crash with a car if the car is driving 50 km/hr.
- Children who are struck by a car were most often not playing in the street and were usually struck mid-block.
- Older adults walking our roadways are the most vulnerable and have the highest rates of injury of all age groups.
Walking, cycling, and jogging along our northern roads is part of the reason we all love to live in the North. We love to get outside and enjoy the long summer days with our friends (and good old dogs!). All of us in our many roles as road users have a responsibility to keep our roadways safe.
Keep in mind:
- Older adults may need a little more time than the crosswalk light provides.
- Playground speed limits save lives. Slow to 30 km/hr or slower between dawn and dusk.
- Families may be out walking so take the time to double check before backing down the driveway.
Together we can all have a fun and safe summer in the great outdoors!
More information
About Natasha Thorne
After many years in southern B.C., Natasha was drawn back to her hometown of Prince George in 2006 by the lure of extended family, sub-boreal forests, and raising her babes exploring the backwoods of her own childhood. Whether nose in a book or in real life, Natasha is an aspiring world traveller planning overseas vacations so she and her husband can give their two children a wider perspective of living in today's global community. As the full time Regional Nursing Lead for Injury Prevention for Northern Health, Natasha is committed to the north and is passionate about supporting the health and well-being of northerners.


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So, I've been thinking about room design again. I thought about it a lot those last few years I taught 5th grade. I did some massive overhauling of my classroom set up and got in the habit of rearranging desks and tables regularly depending on the teaching and learning format of the lesson. It was worth the time and effort.
Then, I moved to edtech in the upper school, didn't teach for a year, and when I went back to teaching a class, I was teaching my one section in someone else's room. In theory we were sharing the room, but I was just a visitor for the most part. Somewhere in there, I forgot about all that room design thinking I did. Or rather, I wrongly thought well, they are high school students, it won't be such a big deal. And, since it's not really my room, it's hard to rearrange and then return the room to its former set up all in 48 minutes. It will be fine.
Ok, well fine is rarely my goal. And, as I have written about this year, the older kids may be bigger, but there are kids in many ways. And, teaching these big kids means remembering all sorts of important pedagogical information, including room design. Here are things I know and need to remember about room design:
- The format of the desks and tables signals the kind of interactions you expect. Don't want people talking, don't put them close together and facing each other.
- Seats (either at tables or desks) should be close to where ever instruction is happening. So, where the teacher desk is needs to support not hinder this. In a couple of the rooms I have shared, the location of the teacher desks has made it very hard to move around and get the students close to the board when that is desired.
- In a 1:1 (laptops for us) environment, I need to be able to see screens and move around easily.
- No arrangement is THE arrangement. It is THE arrangement for THIS learning experience.
- The students can be trained to rearrange the room into a few formats quickly. Putting in some time on this in the beginning is worth it.
- Telling students that the particular arrangement is for a particular purpose is good.
- Being annoyed at students for talking when you have them sitting in groups facing each other is like being mad at the refrigerator for not having food in it. This is my responsibility.
Late in this school year, I finally got back on the room design bandwagon. Since I had my class meeting in literature circles for a lot of the semester, I had to do some rearranging and that got me back in the habit of considering the best arrangement for any given class.
For example, when we had presentations towards the end of the day on the two days before spring break, I made sure the set up the room in formal rows of tables with a table in front for the presenters. It looked formal and said we have two distinct roles in the class today. The presenters were positioned close enough to the projection hook up that they could easily sit or stand, project, and see the room.
During our recent article writing time, I finally set up the room to signal this is independent work time. The tables were separated and in a ring (though not connected) around the room, chairs were set so that students faced out (towards the windows or walls). Other classmates were therefore less of a distraction and, added bonus, I could see the screens. I made this clear it was very purposeful and that this was to be work time. Some students, with lots of room in the center, decided to make themselves comfortable and work lying down, as they do at home. But, they were working.
And then everyone just worked beautifully. Not everyone made good use of the time, but those who did not use the time were not distracting to those who were working. Victory there.
Time to put room design back in the front of my brain.


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Summer Program
(Ages 3 to 6 years)
Our school remains open during the summer months. We still provide our Montessori instruction, but in a slightly more relaxed manner.
Summer at Early World Montessori is a blast.
- Fun and educational
- Swim Lessons
- Field trips each week to museums, parks and beaches
- Transportation in seat belt-equipped school vans
- Summer projects enhance reading, math, science and art skills
Schedule a Tour
For more information please schedule a tour or contact us today. We look forward to meeting you.


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Mission Statement
What You Want is a group of Dj's, Vj's, Dancers, Promoters, and Party Goer's committed to bringing a great vibe to the masses. Whether it be the visuals on stage, the sound on the ground, the lights in the sky, or music for your ears we do it all.
The WYW crew started out as just regular party attendees—people who loved loud music, dancing, and the promise of the electronic scene.
Who we are and what we do.
Here at What You Want Productions we are always looking toward the future. We constantly rethink and rework our way of providing quality event services to our clients. With that we are expanding currently to include these services as well as many others:
What WE DO
We provide the following services:
- Video Projection
- Sound Systems
- Videography
- Video Editing
- Custom Visuals
In addition, we also offer for sale:
- custom video clips
- apparel
Examples of Work
What You Want Productions is a one stop shop for event services. We've worked Thousands of gigs and work on pretty much every aspect of "events". Events itself is a broad term covering a huge range of gigs that have come our way. From small intimate gatherings to massive music festivals, we have done it all.


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Workforce development program to strengthen families and our community
The Continuing Education/Tuition Assistance Program (CETAP) provides funding for single-parent students (full-time or part-time) attending a trade/technical school, college, or university. In addition, this program provides funds to pay for professional fees that help alleviate other barriers to continuing education and employment.
Who are our clients?
Mary was a stay-at-home mom with one son living a comfortable life when everything changed. A divorce, after 8 years of marriage, left her looking for work having been out of the workforce for almost a decade. A medical diagnosis, soon after the divorce, depleted her savings. She and her son are living paycheck to paycheck and looking for a more stable life, so she has returned to school to earn a college degree.
Our clients are single parents who are working to make better livelihoods and build healthier households for themselves and their children. We provide funding for:
- Tuition at 2-year and 4-year accredited colleges and universities
- Tuition for vocational and technical school
- Fees for professional licenses and certifications
- Fees for continuing education credits to renew professional licenses
- Fees for books and supplies


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- Vendor Shipped
- Price Match Guarantee
- Unlimited Flat Rate Delivery
America's best chefs are calling this unrivaled culinary innovation the "ultimate grill." The world's only true hybrid fire grill, Kalamazoo's professional-grade cooking station offers impressive options for everything from sizzling-hot searing to low-and-slow barbecue. Cook using the gas flame only, or enjoy the rich, smoky flavors of cooking over a live fire using charcoal or wood.
- Savor a fully customized grilling experience by choosing any combination of gas, lump charcoal and aromatic wood.
- For the ultimate live-fire cooking, simply fill the Hybrid Fire Grilling System drawer with charcoal or wood – the gas grill burners below will quickly start the fire; for gas grilling, simply leave the drawer empty.
- Three ultra-powerful, 25,000-BTU lead-free cast-bronze burners deliver heat below the Hybrid Fire Grilling Drawer to ensure top performance.
- Expanded firebox engineering creates more even heat for conventional grilling and a convection effect for roasting and smoking.
- 726-sq.-inch grilling surface provides plenty of room to cook for a crowd.
- Chain-driven rotisserie with infrared burner provides the professional performance you need to roast meats and poultry to perfection.
- Flip-up warming rack keeps your grilled food at the perfect serving temperature.
- Ambient control panel lighting.
- Heavy-duty stainless-steel leveling legs provide easy installation.
- Heavy-gauge stainless-steel grills are expertly formed, welded, finished and assembled by hand in Kalamazoo, Michigan.
California Proposition 65 Warning. This product can expose you to chemicals including nickel, which are known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to www.p65warnings.ca.gov
Built-In Grill (Liquid Propane)
- Burners offer a combined total of 75,000 BTUs.
- Overall: 39 1/4" x 32" x 54 1/2" high.
- Grilling Surface: 33" x 22" (726 sq. in).
- 420 lb.
- Made in USA.
Built-In Grill (Natural Gas)
- Burners offer a combined total of 82,500 BTUs.
- Overall: 39 1/4" x 32" x 54 1/2" high.
- Grilling Surface: 33" x 22" (726 sq. in).
- 420 lb.
- Made in USA.
- Delivered with White Glove service and assembly; does not include connecting grill to natural gas line or propane tank.
- Natural-gas models are designed for use with natural gas fuel only.
- Propane-gas models are designed for use with propane fuel only.
- After each use, clean drip tray with hot soapy water or an oven-style cleaning product.
- After each use, wipe down grease splatters on grill exterior. Use a designated stainless-steel cleaner to clean and polish exterior surfaces.
- To clean the grill grates, while the grill is still hot, dip a brush with brass bristles in hot water and scrub to remove charred residue.
- As needed, burn residue off the grill by running the closed unit with main burners on high for at least 30 minutes.
- Once a month, use a natural-bristle painter's brush to sweep ash from all interior surfaces.
- Allow grill to cool and dry thoroughly before covering.
Shipping Information
Please allow four to five weeks for delivery. This item will be shipped directly from the manufacturer and is not eligible for rush shipping. Item arrives fully assembled and in one piece by our in-home delivery with White Glove service. We'll call you in advance to schedule a delivery time, then bring the item into your home, unpack and inspect it, perform simple assembly and dispose of all packaging material. Delivery is by appointment, Monday – Saturday; our delivery service will call to arrange a day. Available in the 48 contiguous states. White Glove Delivery does not include connecting the grill to a natural gas line or propane tank. Please call 877.812.6235 for additional assistance.
Shipping Rates
With Unlimited Flat Rate Furniture & Freight Delivery, an unlimited number of eligible furniture and select non-furniture items in your order can be delivered for a single flat rate. The exact shipping charges, are based on your shipping location and will be applied during checkout.
All items not shipped via unlimited flat-rate delivery fee will incur a shipping surcharge, but no additional delivery fees. View Shipping Options and Charges.
Oversized, very heavy items that ship unlimited flat rate will also incur a delivery surcharge. This additional charge is listed with the product price on the product detail page and also in the shopping cart.
Return Policy
Our products are designed with your comfort and style in mind. Made-to-order items (as marked) are not returnable but may be cancelled only within 24 hours of order placement. We cannot accept cancellations or returns on monogrammed items. Should your item arrive damaged or with a defect, please contact us at 877.812.6235 within 7 days so that we may arrange for a replacement. Frames and springs are warranted to be free of manufacturing defects for the product's life, subject to the following conditions: warranty applies only to original owner and normal residential use. Defects resulting from negligence, abuse or use in a commercial, hospitality or other non-residential setting are not covered. For warranty service, call 877.812.6235.
Williams Sonoma Price Match Guarantee
At Williams Sonoma, we're committed to bringing you the best quality at the best prices.
If you find a lower price on any of our products, we'll match it—guaranteed. Click here for details.
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Prices and promotions may vary in stores. We make every effort to give you current product availability information, but our store inventory is always changing so an item's availability cannot be guaranteed.


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It is widely accepted by all that whole foods are incredibly good for the human body. A whole food is a food that has not been processed or altered in any way that could be considered unnatural; instead, it is as nature intended it, and offers many nutritional benefits as a result.
These nutritional benefits are particularly important if you are looking to lose weight, as you will have fewer calories available to you to nourish your body properly. Below are four of the best diet plans that are suited to eating whole foods, so if you want to protect your health and shed those stubborn pounds, these choices should suit your needs perfectly.
The HCG Weight Loss Plan
The fantastic HCG weight loss plan comprises of injections of HCG and a carefully-monitored whole foods diet. As a result, it provides all the nutrition your body needs, and boosts your ability to lose weight thanks to the injections. If you're looking for rapid weight loss that also encourages you to eat healthy whole foods, then this is just about the best choice.
The Paleolithic Weight Loss Plan
The paleolithic (most commonly shortened to "paleo") diet is based on only eating foods that would have been available to ancient man. That means that, by default, there's no processed foods involved in this eating plan. While some people find the paleo diet a little slow for weight loss, the food you'll eat is highly nutritious and should ensure you feel satiated and comfortable during your time on the plan.
The Atkins Diet
Atkins is one of the most famous diets, and it is possible to adhere to the Atkins rules and eat whole foods— but you have to avoid the patented "Atkins" products. Instead of buying pre-packaged meals and snacks, you can stick to the low-carb-high-protein rules of Atkins by sourcing foods with the same macronutrients for yourself. As a result, you should find this a more effective, healthier, and cheaper way of sticking to the principles of Atkins in an effort to lose weight.
The Raw Food Diet
By its very nature, the raw food diet is supportive of whole foods. As food is not to be cooked over a certain temperature (the exact number varies between proponents, but 40C/104F is the general benchmark), then the majority of cooking techniques involved in producing processed food just cannot be used. As a result, you should be able to adhere solidly to a raw food diet that is full of beneficial whole foods that can nourish your body even while you're steadily losing weight.
In conclusion
Finding the right diet or eating plan for you is always a case of experimentation and finding what suits your tastes, but you also have to take nutritional value into account. To ensure you are losing weight comfortably and safely, without denying your body what it needs in order to function, opt for one of the whole food weight loss plans above— you'll lose weight and keep your physical health in tip-top condition.


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Topic: Android
Samsung, Google to scale back giant screen sizes on new Android phones
05/30/2013, 05:05 am
While Apple has been the subject of incessant queries wondering when it will follow Samsung and Google's Motorola subsidiary in making a big screen iPhone, both Android licensees are now planning new phones with screens closer in size to iPhone 5.
HTC next to accuse Samsung of using component supplies as a "competitive weapon"
05/29/2013, 03:05 pm
Apple isn't the only company grappling with its relationship to Samsung as both a smartphone component supplier and handset competitor. HTC recently complained that Samsung has "strategically declined" to provide it with crucial parts for years.
iPhone owners spend 55% more time on their phone than Android users
05/29/2013, 09:05 am
New smartphone usage data shows that iPhone owners spend an additional 26 minutes per day on Apple's handset more than the average Android device user.
IDC sees tablet shipments eclipsing notebooks this year, all PCs in 2015
05/28/2013, 11:05 am
Led by devices with screens smaller than 8 inches, tablets are expected to surpass notebook PC shipments this year to become the predominant non-smartphone mobile computing platform.
Samsung teases new Android, Windows devices for June 20 event
05/27/2013, 02:05 pm
On the heels of launching its latest flagship smartphone, the Galaxy S4, Samsung is now gearing up to introduce more Android devices, as well as new Windows products, at a June 20 event in London.
Editorial: Apple's iOS 7 needs exclusive, distinctive features, not just a flat UI
05/25/2013, 04:05 pm
There's intense interest blooming around reports that Apple plans to revamp the look of iOS 7 with a flatter appearance. But there's more reason to believe that Apple is - or should be - focusing on features, not a radical new appearance.
Google's new 3D Maps destroy Manhattan in the wake of Apple's Flyover
05/22/2013, 06:05 pm
Nearly a year after Apple introduced its own Maps service in iOS 6 with Flyover 3D satellite views, Google is expanding its own online Maps to support similar 3D satellite imagery, with the same sorts of buckled roads and visual distortions Apple was castigated for last summer.
Apple's iPad dominates online shopping traffic & revenue generation
05/22/2013, 01:05 pm
Despite growing competition from other tablets, Apple's iPad still accounts for a whopping 89.28 percent of e-commerce website traffic, and also rakes in more money on a per-user basis than any other platform.
Samsung Galaxy S4 & Google Now accused of violating Apple patents for Siri
05/22/2013, 10:05 am
In its ongoing litigation against Samsung, Apple has added five new patents to its claims, targeting both the company's new flagship Galaxy S4 smartphone, as well as the Google Now service for Android.
Looking to pull even with Apple, Samsung to pay developers for Galaxy-specific apps
05/20/2013, 09:05 am
Apple rival Samsung is turning to third-party developers to help improve the standing of its smartphone lineup against the iPhone, offering $800,000 in prize money for Galaxy-specific apps.
Google engineers talk fragmentation, how to make Android work for emerging markets
05/18/2013, 09:05 pm
This week's Google I/O saw no announcements of any new versions of the company's mobile operating system, Android, and that may be because the team that is building the system is working to address the platform's biggest problem: fragmentation.
Revenue from iOS, Android gaming apps now three times greater than portable consoles
05/17/2013, 04:05 pm
The trend that's seen portable gaming shifting largely to devices like Apple's iPhone continues apace, according to a new report that pegs revenue from gaming on iOS and Android devices at three times the size of revenue on dedicated portable gaming consoles.
IDC: Apple's iOS fell to 17% of smartphones shipped in Q1, Windows Phone passed BlackBerry
05/16/2013, 08:05 am
Gains made by Google's Android platform chipped away at the smartphone market share of Apple's iOS in the first quarter of 2013, while Microsoft's slow-growing Windows Phone managed to surpass BlackBerry in the battle for third place.
Google Play game services offers cross-platform support on iOS, Android and Web
05/15/2013, 12:05 pm
Google's response to Apple's Game Center was announced on Wednesday in the form of Google Play game services, a cross-platform series of developer tools that will support iOS as well as Android and the Web.
Google announces 900 million Android activations, 48 billion app installs
05/15/2013, 12:05 pm
Google on Wednesday announced that its Android mobile platform has seen 900 million total activations to date, while 48 billion applications have been installed on Android devices.
iPhone's popularity among Facebook staff may have aided in Home's lackluster launch
05/15/2013, 11:05 am
The launch of Facebook's Home layer on Android appears to have been a flop, with relatively low installation rates and even lower user ratings on Google Play thus far. Now, some observers are blaming an unlikely candidate: Apple's iPhone.
Mobile malware exploding, but only for Android
05/14/2013, 06:05 pm
Malware targeting mobile devices is rapidly growing in both the number of variants found in the wild and in their complexity and sophistication, but the only platform being actively targeted is Google's Android, which researchers now say is resembling Windows on the desktop PC.
BlackBerry BBM coming to Apple's iOS, Google Android this summer
05/14/2013, 11:05 am
BlackBerry's BBM messaging service will go cross-platform this summer, when official BBM applications will launch on iOS and Android.
Apple fell to 18% share of smartphone sales in Q1, Gartner says
05/14/2013, 10:05 am
While Apple increased its iPhone sales year over year, its share of the global smartphone market shrank to 18.2 percent in the first quarter, according to data from Gartner.
Google's Android on 59.5% of all 'smart mobile devices' shipped in Q1, Apple at 19.3%
05/10/2013, 03:05 am
According to research firm Canalys, Google's Android platform continues to dominate the worldwide mobile marketplace as the OS powered 59.5 percent of the nearly 310 million smart mobile devices shipped in the first quarter, while Apple managed to grow its iOS and OS X presence to a 19.3 percent share.


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- Description
The HDC6555 is a compactor plate, often referred to as a wacker plate, made by Evopower. The model is from the brand new line of Evopower wacker compactor plate series for 2012 and is a re-design of the popular 2011 series. Weighing in at 65kg it features a compaction plate which measures 53cm x 37cm, and is a slighty larger plate size then the HDC5028, meaning that you can cover more ground in a quicker time, which will help you get the job done and more importantly cut down on your fuel consumption and labour costs. On this model, we have continued to use the bulletproof Loncin engines to drive the machine, and this compactor plate uses a 5.5hp Loncin covered by a 2-year engine warranty. All of these characteristics make the Evopower HDC6555 the ideal compactor plate for ground work, and the new design has improved upon the reliability and also the commercial grading of this machine, so it is ideal for both DIY and higher level hobbyist use, as well as for contractors and builders. This machine can be used on driveways, patios, for block paving, as well as for garage extensions and conservatory foundations.
- Specification
Warranty 1 year parts and labour Manufacturer Evopower
- Videos
- Delivery
We provide FREE SHIPPING to mainland UK. Pricing for extended shipping areas like Northern Ireland, the Scottish Highlands and outlying Islands (Outer Hebrides, Channel Islands, Isle of Man, Scilly Isles, etc) can be found on the map below.
For full shipping and delivery terms and conditions, please click here.NB. Carriage is also chargeable on all parts and items under £100 in value, and our sales team may contact you for after a sales order has been made if additional carriage surcharges need to be applied.
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Joan of Arc & Medieval Philosophy in Context
This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!
Do you find some similarities and differences between Joan of Arc's life and times and that of medieval philosophy? What are your thoughts?© BrainMass Inc. brainmass.com October 10, 2019, 2:19 am ad1c9bdddf
Solution Preview
As the question is framed, you need to identify the areas of Joan of Arc's life that are relevant to philosophical discussion. The areas that are relevant would include her visions, the attempts to determine her suitability to lead the French in battle on the part of the King and other political leaders of the time, and much of the theological and political considerations at her trial. It is a bit odd to talk about "similarities and differences" in this context. Perhaps a better choice of words would be "what was a reflection of the times and what was unique about the life and situation of Joan of Arc's life and times."
The areas of uniqueness, would, I think, focus on the fact that Joan was a military leader and yet was a woman. The fact that she wanted to do this was remarkable enough, but the fact that she was able to convince the King and other political leaders to develop military strategy, and that she was actually on the battlefield herself was ...
Solution Summary
Provides advise in tackling the task of comparing and contrasting the life & times of Joan of Arc to the events and development in Medieval philosophy.


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This week was pretty typical for us, just busy doing what we do. We actually had a pretty good week here, managing to get through all our days fairly unscathed. Minimal fighting, which is always a good thing. We made Butterfinger Cake, which is really yum, but I suggest eating it within the first couple hours after you have made it. Once it sits for a while the cake gets mushy from the carmel and it just isn't as good!
We spent a considerable amount of time away from the house, going swimming with friends, playing at the sprayground with our cooperative and visiting Fernbank Museum (just the 3 of us). It felt like our last hurrah at enjoying some summertime fun, since we are only a week away from starting our First Grade work, which means moving away from the lighter summer schedule.
Two weeks ago, we finished our unit on The Human Body (Blog coming soon!), and since then we have been enjoying some nature study using the monthly nature grid challenges that get sent out in the newsletter from The Handbook of Nature Study Blog. <3 that blog. We glue the grids into our Science notebook, so we can mark them off as we go, and add pictures of the some of the ones we have accomplished. We went on a bug hunt! Put our feet in mud & danced in it! And we made sun tea.
We started our Draw. Write. Now. curriculum. Haden's first assignment was drawing a hen, which turned out great! I was so proud of him, and he was pretty pleased too. I'm feeling really glad I made this particular purchase. He has been drawing hens all week, and his confidence in his drawing ability has made a serious jump. He actually drew me a lion and a duck, which are two things I did not work with him on at all. This from a kid who rarely tries to draw, because he gets so frustrated that his stuff never turns out the way he wants it.
I had the chance last week to buy the Elemental Science Kindergarten curriculum used, and decided to jump on it. Although, I pieced together our science for this upcoming year, I have been eyeballing and feeling pretty sure that I wanted to try Elemental Science for Second Grade. So, now having the Kindergarten version will give me a chance to test the waters with it this year and see if it will be a good fit for us, but I think it will. I spent the better part of the night reading through the lesson plans and I love the way it is set up.
It is a notebooking curriculum, uses the book Science Play as it's spine, and is broken down into Nine 4-week units (the Kindergarten version). I think we will be working in the units on Plants, Chemistry, Motion, and Earth. I'll let you know if I love it. 😉
Although, my week was pretty good, there are two sad notes to add. My best friend, Cassi, finally found a job in California, and will be moving at the end of next week. I am completely bummed, but in a way, I think I am in denial. I've been avoiding thinking about it, because then I can just pretend it isn't happening… This next week will likely be a hard one for me.
Plus, my boy is sick! He seems to be on the mend though, so I'm hoping he feels better by tomorrow.


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Programs » Physiological and Pathological Processes » Metabolic and Signaling Networks in Disease Unit
G protein-coupled receptor networks: signal transduction and pathophysiological implications
Federico Mayor Jr.
Research summary:
Our laboratory is investigating key nodes in signalling networks involved in prevalent age-related pathologies such as metabolic/cardiovascular diseases and cancer. The GRK2 kinase is one of those key signalling hubs. In addition to its canonical role as a regulator of G protein-coupled receptors (GPCR), GRK2 can also impact cell signalling networks by directly interacting and/or phosphorylating non-GPCR components of transduction cascades (such as HDAC6, IRS1, PI3K, EPAC, Mdm2, Smads or p38 Mapk). Such integrated interactions underlie the participation of GRK2 in the control of cell migration, angiogenesis or insulin resistance (IR).
GRK2 levels/activity are altered in human pathologies such as cancer, inflammation and cardiovascular/ metabolic diseases related to IR. We seek to understand how concurrent changes in GRK2 levels (involving different cell types and tissues) integrate at the cellular and organism level, and how they can foster disease progression, by using cellular and animal models (including hemizygous, conditional and tissue-specific GRK2-deficient animals).
We investigate how changes in GRK2 expression in different tumor cell types (tumoral, macrophages and endothelial cells) might act synergistically to promote different aspects of tumor progression (proliferation, survival, senescence, genomic stability, angiogenesis, metastatic invasion) by modulating either GPCRs, the HDA6 or the Mdm2/p53 signaling axis, among others.
On the other hand, we analyzwe the GRK2 hub as a central integrator of signaling cascades relevant to IR-related pathologies and co-morbidities in different tissues and cell types (adipose, liver, pancreas, heart, macrophages/immune cells), by simultaneously modulating both the insulin cascade and key GPCRs controlling metabolic homeostasis, nutrient sensing or insulin secretion/sensitivity.
Other signaling node related to GRK2 is Gαq. We have unveiled novel interactions of Gαq with PB1-domain containing proteins such as PKCζ, and we are investigating the functional impact of this new Gαq interactome in cell death, autophagy and oxidative stress processes and in the development of cardiovascular diseases.
- New phosphorylation site of mitogen-activated protein kinases, modified proteins and applications EP 1899461B1 /WO 2007/028430 Awarded 2010.
- p38 inhibitor peptides and applications. PCT/ES2011/070774.
- Protection of the effects of p38 inhibitory compounds. PCT/ES2012/070762.