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Point-of-Care Measurement of Clopidogrel Responsiveness Predicts Clinical Outcome in Patients Undergoing Percutaneous Coronary InterventionResults of the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome) Study
Author + information
- Received March 25, 2008
- Revision received June 5, 2008
- Accepted June 9, 2008
- Published online September 30, 2008.
Author Information
- Giuseppe Patti, MD, FACC,
- Annunziata Nusca, MD,
- Fabio Mangiacapra, MD,
- Laura Gatto, MD,
- Andrea D'Ambrosio, MD and
- Germano Di Sciascio, MD, FACC⁎ (g.disciascio{at}unicampus.it)
- ↵⁎Reprint requests and correspondence:
Prof. Germano Di Sciascio, Department of Cardiovascular Sciences, Campus Bio-Medico University, Via Alvaro del Portillo, 200, 00128 Rome, Italy
Objectives The aim of this study was to evaluate the correlation of point-of-care measurement of platelet inhibition with clinical outcome in patients undergoing percutaneous coronary intervention (PCI).
Background Individual variability of clopidogrel response might influence results of PCI.
Methods A total of 160 patients receiving clopidogrel before PCI were prospectively enrolled. Platelet reactivity was measured by the VerifyNow P2Y12 assay (Accumetrics Inc., San Diego, California). Primary end point was 30-day occurrence of major adverse cardiac events (MACE) according to quartile distribution of P2Y12 reaction units (PRU).
Results Primary end point occurred more frequently in patients with pre-procedural PRU levels in the fourth quartile versus those in the lowest quartile (20% vs. 3%; p = 0.034), and it was entirely due to periprocedural myocardial infarction (MI). Mean PRU absolute levels were higher in patients with periprocedural MI (258 ± 53 vs. 219 ± 69 in patients without; p = 0.030). On multivariable analysis pre-PCI PRU levels in the fourth quartile were associated with 6-fold increased risk of 30-day MACE (odds ratio: 6.1; 95% confidence interval: 1.1 to 18.3, p = 0.033). By receiver-operating characteristic curve analysis, the optimal cut-off for the primary end point was a pre-PCI PRU value ≥240 (area under the curve: 0.69; 95% confidence interval: 0.56 to 0.81, p = 0.016).
Conclusions This study indicates that high pre-PCI platelet reactivity might predict 30-day events. Use of a rapid point-of-care assay for monitoring residual platelet reactivity after clopidogrel administration might help identify patients in whom individualized antiplatelet strategies might be indicated with coronary intervention.
Optimal platelet inhibition plays a key role in the prevention of early myocardial ischemic complications during percutaneous coronary intervention (PCI) (1,2); accordingly, the association of aspirin and clopidogrel, a nonreversible P2Y12 platelet receptor inhibitor, represents the established antiplatelet therapy in this setting.
Because of inter-individual variability in clopidogrel responsiveness, platelet function monitoring assays are useful tools to identify patients with different drug responses who might potentially be at increased risk of recurrent cardiac events or bleeding. Adenosine diphosphate (ADP)-induced light transmittance aggregometry (LTA) is the standard test for evaluating platelet reactivity in patients receiving clopidogrel, but this is nonspecific and time-consuming (3); conversely, more rapid and specific tests measuring clopidogrel response in the individual patient might be widely applicable in clinical practice, thereby providing risk stratification and a guide to antithrombotic therapy. Thus, the ARMYDA study group (1,4–7) has designed the ARMYDA-PRO (Antiplatelet therapy for Reduction of MYocardial Damage during Angioplasty-Platelet Reactivity Predicts Outcome) study to prospectively evaluate whether point-of-care measurements of platelet inhibition predict clinical outcome in patients undergoing PCI.
Study population and design
The ARMYDA-PRO is a prospective study including 160 patients receiving clopidogrel before PCI. Patients with a variety of coronary syndromes, including non–ST-segment elevation acute coronary syndromes (ACS) were enrolled. Exclusion criteria were: primary PCI; platelet count <70 × 109/l; high bleeding risk; and severe chronic renal failure (serum creatinine >2 mg/dl). All patients received 600 mg clopidogrel load approximately 6 h before intervention (n = 120) or were receiving chronic clopidogrel therapy (75 mg/day for ≥5 days, n = 40). Clopidogrel was continued for 1 month after PCI and for 12 months in patients with ACS or receiving drug-eluting stents. All patients received aspirin.
Platelet reactivity was evaluated in the catheterization laboratory before PCI and at 8 and 24 h after intervention by the VerifyNow P2Y12 assay (Accumetrics Inc., San Diego, California), which is a rapid cartridge-based assay specifically measuring direct effects of clopidogrel on the platelet P2Y12 receptor. Technical details were already described elsewhere (8). Results are expressed as P2Y12 reaction units (PRU)—the lower the PRU value, the greater the degree of P2Y12 receptor inhibition by clopidogrel and vice versa. Twenty randomly selected patients were analyzed to assess intra-assay variability, which was 2.1 ± 1.3% (coefficient of variation: 6%).
Blood samples were also drawn before and at 8 and 24 h in all patients for creatine kinase-myocardial band (CK-MB; mass) and troponin-I (Tn-I; mass) levels; further measurements were obtained if symptoms suggested myocardial ischemia. Measurements were performed by Access 2 Immunochemiluminometric assay (Beckman Coulter, Fullerton, California); normal limits were ≤4 ng/ml for CK-MB and ≤0.08 ng/ml for Tn-I. One-month and 6-month clinical follow-up were obtained by office visit in all patients. Each patient gave informed consent to the study. The study was not supported by external sources of funding.
End points
Primary end point of the ARMYDA-PRO study was 30-day incidence of major adverse cardiac events (MACE): cardiac death, myocardial infarction (MI), target vessel revascularization, in relation to quartile distribution of platelet reactivity measured by PRU assay. Myocardial infarction was defined as post-procedural increase of cardiac biomarkers (Tn or CK-MB) >3 × 99th percentile of the upper reference limit (9). Target vessel revascularization included by-pass surgery or repeat PCI of the target vessel(s).
Secondary end points were: 1) evaluation of mean PRU absolute values in patients with or without post-PCI elevation of markers of myocardial damage (CK-MB, Tn-I); 2) distribution in PRU quartiles of patients with any post-procedural increase of cardiac markers above normal limits; 3) correlation of vascular/bleeding complications to PRU quartiles; and 4) clinical outcome at 6-month follow-up. Bleeding events were defined according to Thrombolysis In Myocardial Infarction criteria (10).
On the basis of patients' enrollment criteria, we assumed 8% overall incidence of 30-day MACE (1,11). We tested the hypothesis that incidence of 30-day MACE differed by PRU quartiles. We assumed as effect size for the power analysis a 7-fold increased risk of 30-day MACE in patients of the fourth quartile (12); thus, a study population of at least 153 patients would be needed to verify this hypothesis with alpha of 0.05 (2-tailed) and beta of 0.08.
Continuous variables were compared by t test for normally distributed values; otherwise the Mann-Whitney U test was used. Proportions were compared by Fisher exact test when the expected frequency was <5; otherwise the chi-square test was applied. Event-free survival analysis was performed by Kaplan-Meier method with log-rank test group comparison. Odds ratios (ORs) and 95% confidence intervals (CIs) investigating the independent predictive role of PRU quartiles on the occurrence of the primary end point were assessed by logistic regression. The following parameters were first evaluated in a univariate model: comparison of PRU quartiles (fourth vs. first quartile, third vs. first, second vs. first); each of the variables indicated in Table 1; and procedural variables, such as stent length, direct stenting, inflations duration. Only variables with p value <0.15 were then entered into the final model of multivariable logistic regression analysis. Ability of the assay to discriminate between patients with and without MACE at 30 days was evaluated by receiver-operating characteristic (ROC) curve analysis. The optimal cut-off value was calculated by determining the PRU value providing the greatest sum of sensitivity and specificity. Results are expressed as mean ± SD. A p value <0.05 (2-tailed) was considered significant. Analysis was performed with SPSS 12.0 (SPSS Inc., Chicago, Illinois) software.
Clinical and procedural characteristics according to pre-intervention PRU quartiles are indicated in Table 1.
Procedural success was obtained in 99% of patients. No vessel or side branch (≥2 mm) closure occurred. No patient required emergency coronary artery by-pass graft.
Primary end point
Occurrence of composite primary end point was significantly more frequent in patients with pre-procedural PRU levels in the fourth quartile versus those in the first quartile (20% vs. 3%; p = 0.034) (Fig. 1); this was essentially due to periprocedural MI. No further event occurred during 1-month follow-up.
Secondary end points
Higher PRU values before PCI (Fig. 2A) predicted periprocedural MI by CK-MB definition (258 ± 53 PRU in patients with MI vs. 219 ± 69 PRU in those without MI; p = 0.030) but not by Tn-I (Fig. 2B).
Likewise, any post-procedural increase of CK-MB above upper normal limits was more frequently observed in patients in the fourth PRU quartile (48% vs. 23% in the first quartile; p = 0.035), but there was no difference in the proportion of patients with Tn-I elevation (65% in the fourth quartile vs. 45% in the first quartile; p = 0.12).
No relationship was found between MACE and PRU levels at 8 and 24 h after PCI (p ≥ 0.30).
No patient had major bleeding or required transfusions; minor bleeding occurred in 9 patients (6%): 1 patient had urethral bleeding from a Foley catheter and 8 had small entry-site hematomas, independent of baseline PRU quartiles. There were no side-effects in either group requiring discontinuation of clopidogrel. At 6-month follow-up, the cumulative incidence of MACE was 10% in the first quartile, 13% in the second, 17% in the third, and 30% in the fourth quartile (p = 0.05 first vs. fourth quartile).
Multivariable analysis
Whereas the comparison of third and second quartiles versus first was not different (p = 0.68 and p = 0.71, respectively), multivariable analysis revealed that pre-PCI PRU levels in the fourth quartile were independent predictors of higher risk of adverse events at 30 days (OR: 6.1; 95% CI: 1.1 to 18.3; p = 0.033). Age >70 years, left ventricular dysfunction, and use of glycoprotein IIb/IIIa inhibitors were also associated with increased risk, whereas statin therapy at the time of PCI had a protective effect (OR: 0.21; CI: 0.10 to 0.91; p = 0.037) (4,7).
ROC curve analysis
The ROC curve analysis showed that PRU levels significantly discriminate between patients with and without 30-day MACE with an area under the curve of 0.69 (95% CI: 0.56 to 0.81; p = 0.016). A PRU value ≥240 was identified as the optimal cutoff point to predict 30-day outcome, with sensitivity of 81% and specificity of 53%.
This prospective study indicates that high residual platelet reactivity after clopidogrel administration, measured by a point-of-care assay at the time of intervention, is associated with higher incidence of 30-day MACE after PCI; this outcome is mainly driven by increased risk of periprocedural MI.
Evaluation of individual clopidogrel responsiveness is an emerging issue in interventional cardiology. Wide variability is reported (13), ascribed in turn to differences in drug absorption, variations in biotransformation rate into active metabolite (due to drug–drug interactions at the site of cytochrome P or genetic CYP3A polymorphisms) (14), P2Y12 receptor polymorphisms affecting receptor number and activity (15), and even noncompliance (16). The prevalence of reduced clopidogrel responsiveness varies from 4% to 30% (2,13,17), depending on the assay used, definitions empirically applied, and presence of potential confounders.
Several methods have been used to evaluate clopidogrel response in patients undergoing PCI, with the aim of identifying those at higher risk of adverse events (18), with optical aggregometry after ADP stimulation being the most widely used in previous studies. A low platelet response to clopidogrel measured with LTA was associated with increased incidence of periprocedural myocardial injury (19), cardiovascular events at short- (12,20) and midterm (2,21), and stent thrombosis (22). Nevertheless, this test has a number of limitations, such as need for highly trained personnel, repeated centrifugations, large sample volume, length of assay time, and suboptimal reproducibility (3). Furthermore, it is nonspecific, because it also measures aggregation due to binding of ADP to P2Y1 platelet receptor, which is not inhibited by clopidogrel.
Vasodilator-stimulated phosphoprotein phosphorylation by flow cytometry is more specific, because it directly measures effects of the drug on the target receptor; in observational studies, a lower platelet inhibition assessed by vasodilatator-stimulated phosphoprotein was observed in patients with stent thrombosis (22). Cost and need for long sample preparation and skilled personnel limit a widespread use of this test (3).
Platelet reactivity by VerifyNow can be rapidly measured without sample preparation by moderately experienced personnel with low sample volumes; the test specifically reflects the extent of ADP-induced inhibition of adenylyl cyclase, which is mediated uniquely by action of clopidogrel on the P2Y12 receptor. The assay allows detection of absolute PRU values and percent P2Y12 receptor inhibition, which might be calculated as a percent change from baseline platelet aggregation (8,23). A close correlation was described between results of ADP-induced optical aggregometry and absolute PRU values by VerifyNow assay in patients undergoing PCI (24). This method was also tested and clinically validated in a multicenter prospective study (VERITAS [VERIfy Thrombosis risk Assessment]) (23).
In this study we demonstrate the correlation between clopidogrel response and clinical outcome after coronary intervention. Although multivariable analysis might be overfitted, given the number of end point events included, the predictive value for adverse events of the fourth quartile of platelet reactivity was independent of possible confounding factors, with a 6-fold increased risk of periprocedural MI versus the first quartile. An ROC analysis indicated that this assay can predict outcome at 30 days, with optimal cutoff point to discriminate patients at higher risk of events of ≥240 PRU, and a positive predictive value of 81%. The threshold identified in our study coincides with that observed by Price et al. (25) in an observational study in which a cutoff ≥235 PRU correlated with 6-month events, including stent thrombosis, in patients receiving sirolimus-eluting stents. In ARMYDA-PRO, the negative predictive value of PRU in the first quartile was 98%, with minimal probability of early adverse events with PRU levels <178. Interestingly, higher PRU values correlated with CK-MB elevation but not with Tn-I elevation, suggesting that platelet-unrelated events (i.e., distal embolization) might be also responsible for Tn raise after PCI (12). No cut-off value for events was described in a recent study (26) on stable patients treated with drug-eluting stents after variable loading doses of clopidogrel (300 or 600 mg) that also used VerifyNow.
We used quartile distribution, because clopidogrel responsiveness is multifactorial and it should be considered as a continuum; accordingly, a progressively increasing incidence of events was observed across PRU quartiles (Fig. 1), with a similar pattern of correlation between PRU values and peak levels of myocardial markers (Fig. 2).
Unlike the Price et al. study (25), ARMYDA-PRO was not powered to evaluate relationship between degree of clopidogrel inhibition and occurrence of bleeding complications or late thrombotic events; larger prospective studies with longer follow-up are needed to address this issue.
Clopidogrel responsiveness variability, within the enhanced thrombotic milieu of PCI, requires careful evaluation. The ARMYDA-PRO study supports the use of a rapid point-of-care assay for monitoring residual platelet reactivity after clopidogrel administration: VerifyNow can be a useful and easily applicable method that might help establish a clinically driven threshold of platelet reactivity that would identify patients at higher risk of periprocedural events; in those, individualized antithrombotic strategies (i.e., restricted use of drug-eluting stents, more extensive use of glycoprotein IIb/IIIa inhibitors, higher clopidogrel maintenance dose, or use of newer P2Y12 receptor antagonists) might be indicated to improve clinical outcome after coronary intervention.
- Abbreviations and Acronyms
- acute coronary syndromes
- adenosine diphosphate
- creatine kinase-myocardial band
- light transmittance aggregometry
- major adverse cardiac events
- myocardial infarction
- percutaneous coronary intervention
- platelet (P2Y12) reaction units
- receiver-operating characteristic
- Tn
- troponin
- Received March 25, 2008.
- Revision received June 5, 2008.
- Accepted June 9, 2008.
- American College of Cardiology Foundation
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- Thygesen K.,
- Alpert J.S.,
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- Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction
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- Hochholzer W.,
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Category Archives: Sierra Banquet-Camino
Jamie and Roman ~ Sierra Banquet Center
9.20.14: the wedding day of Jamie and Roman, and the infamous King Fire started just one week before. If you were getting married that weekend in the Pollock Pines area, you weren't really sure where your wedding would be. Afterread more »
Kate and Evan Celebrate @ Belle Vista and Sierra Banquet Center
Kate and Evan are from Pollock Pines or at least have lived here for a long time. They met at Sly Park Lake working together. Their wedding gave a lot of local vendors a chance to get together and help to make their big day shine. Kate andread more »
Amber & Brad ~ Engagement
Brad just received his masters degree in journalism and Amber works for the California State Senate. We went to Sierra Banquet Center – a beautiful new log structure for weddings and events in Camino – for their engagementread more »

subset: commoncrawl


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December 11, 2019
425 Granbury Street Room 7 & Room 102
Join us each Wednesday night for Adult Bible Study and Children's Class. We meet at JN Long Cultural Arts @ 425 Granbury Street, Rm. 7 & Rm. 102. Come join with us as we go deeper in the Word in an interactive setting. Together we get to grow in our walk in a very comfortable setting!


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Check out what's new at Shout it Out Design, and what we're loving this month!
As we near Halloween, I'm trying to hold off until the last second to buy candy for the lil' Trick-or-Treaters that roam our neighborhood. The longer it's in the house, the bigger problem it becomes. If I could just give out individual gift cards for mini-Snickers, I would.
Rachel and I took turns this month on some of our favorite brain food resources. Here's Rachel's article, and here is mine.
I found this great article on the producer-oriented model of marketing and how it might be in need of a revision. If you're not familiar with the 4 P's of Marketing, don't worry – they're on their way out.
For those of you who have 'furry children' running around at home – a wearable GPS device for your canine might be a good investment. I might get one for this mobile little girl in our house. Either that or tie a cow bell around her!
A 'smart' Cuckoo clock? Sure – why not?
Gmail user? Here are some 'power user' tips for you to make it through your work day.
Your customers are spending time on social media – are you doing anything other than sharing cat videos? You should be!
…and by the way. If you didn't catch the above reference from this section's title… Do yourself a favor and watch this clip from one of the greatest comedies of all time.
Have you ever stopped and said "I wish I could see 19 minutes of every time Tom Cruise was running in a movie?" Well, I found a clip you might be interested in.
I've been checking out more photo-related articles lately and found two that I think you'll be interested in: Wildlife Comedy Photo Contest Finalists and some super-cool air traffic photos (believe me, they are cool!)
If you're a frequent customer of Young's Dairy – be prepared to see this photo everywhere next year, and the year after and the year after… We finally got this girl with an ice cream cone in hand and smiling. Took a lot of ice cream, but she didn't seem to mind the practice shots.
Want to see more cool stuff from Shout it Out Design? Check out our blog.


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This circular trail explores the Moor Green Lakes Nature Reserve and surrounding woodland of the Blackwater Valley. Careful restoration of gravel workings has created a haven for wildlife in a series of small lakes beside Blackwater River. The walk is along established and well maintained paths and is suitable for the whole family.
- Walk
- 3.4 miles / 5.4 kms
- 171 feet / 52 metres
- Add to Basket
- Walk and Cycle
- 27 Oct 2010
The trail starts at the Horseshoe Lake Activity Centre. Follow the A321 to Sandhurst. Turn into Lower Church Road by the church. Follow the road for about half a mile. Turn left at the T-junction (Mill Lane) and the entrance to the site is on the right after a short distance.
The Walk
From the car park follow the gravel path to the corner of the lake. Just before you reach Mill Lane, turn right and keep to the Blackwater Valley footpath that runs between Blackwater River on the left and the lake on the right.
At the end of Moor Green Lakes Nature Reserve, and after passing the footbridge over the river on your left, turn right. The path divides and runs both sides of the hedgerow. For views across the nature reserve and for access to a viewing station, take the path on the right.
At the end of the lake continue through the car park and then turn right onto the lane. After the post box and before the right bend in the road, turn left up the side of Hall Farm. Keep to the track as it climbs steadily. On the left of the track is Finchampstead Ridges, beautiful National Trust woodland that can be explored. Our trail continues along the track to the summit of the hill and then turns immediately right to traverse the top of the ridge.
Follow the footpath out of the woods as it descends first between two open fields and then along the edge of Coalpit Copse. Bear left through the woods and descend gently to the lane. Turn left along the lane and then right onto the footpath at the sharp left bend in the lane. Keep to the right side of the fields, cross over the road and return to the car park beside the lake.
Moor Green Lakes Nature Reserve
The reserve, opened in 1993, has been established through the careful restoration of gravel workings. Covering 36 hectares it is an important site for breeding and wintering birds and there are three lakes with gravel islands that attract wildfowl for breeding and loafing. A number of scrapes have also been created to attract wading birds. Over 200 species of bird have been recorded in this area of the Valley. The lakes are fringed by Willow, Ash, Hazel, Maple and scrub and the northern and western edges of the reserve are managed as grassland which contains a wide variety of native meadow plants.


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Tokyo is still mostly a bustling, crowded supercity. But the quiet and emptiness I saw with my son this fall in the greenway adjacent to the Imperial Palace grounds in Tokyo could be more commonplace later in this century given the aging of the Japanese population. Indeed, a recent government study, cited last year in the Wall Street Journal's Japan blog, projected that the city population "will peak at 13.35 million in 2020 — then drop steadily to 7.13 million in the year 2100."
But the indicator of demographic shifts that got me writing today was a diaper trend noted by my longtime contact on population and immigration, Joseph Chamie. Here's an excerpt from the Asahi Shimbun article he forwarded:
As Japan's birthrate declines and its population ages, the country's future can be foreseen in diaper sales.
Over the past decade, production of adult diapers, essential for caring for the elderly, has doubled in Japan.
Unicharm Corp., a major diaper maker, saw sales of adult diapers outpace infant diapers in the last fiscal year ending March 31, while forecasts indicate the same will happen throughout the industry over the next few years.
At an outlet of Tomod's drugstore in Kawasaki, infant and adult diapers take up roughly the same amount of shelf space.
And, by the way, Joseph Chamie isn't just somebody. He is the former Director of the United Nations Population Division, so in fact we do pay attention when he says something like this.


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Wives: Compete or Complete?
What cuts against both the oppression of women and feminism? Biblical womanhood. In marriage, this means the wife willingly submits to her husband, who willingly sacrifices for her. To hear what submission is & is not, and what it's ultimate purpose is, you can listen to this message from Ephesians 5:22-24, Redeemed Helpership, HERE.
We had a great week of ministry partnership and deepening relationships with the Berean Baptist Church youth team! You can check out the video below, produced by a Berean team member, for a great overview of the week.
Next Sunday 11 AM we return to Gordon Park for outdoor worship & a cookout. Hope to see you there July 6!


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Get in shape with water aerobics! A fun way to exercise, water aerobics make working out so much easier and fun. Here's how to get in shape with water aerobics.
Get in shape with water aerobics that can make working out so much fun and comfortable. It is a great way to lose weight because of the variety of exercises you can perform in water.
Water supports more than half of your body weight about 80% so it is less likely to injure your muscles, bones, back and joints. Exercises are usually done in chest deep water. The water provides support and buoyancy for the body. Because water is more dense than air you increase the muscle endurance and tone body more efficiently.
Since water supports most of the weight you can increase
flexibility without experiencing any pain in the joints.
This is why water aerobics can be a great option for older people as well.
Water aerobic maintains the heart rate level low compared to other exercises done 'on land'. The water keeps the body cool making it more comfortable and more endurable.
Water is more dense than air so you work your muscles better and feel much comfortable therefore the weight loss will be more significant. In one hour of water aerobic workout you can burn up to 700 calories.
The equipment you will need depends on how advanced you get. You will need:
- swim suit
- water aerobic shoes to provide traction and prevent injury
- goggles if you get under water
- swim cap
- aqua blocks for increased resistance
- foam filled cylinders for deep water exercises
- flotation belt
- kickboard
So give it a try and see how you like it because for sure you will not regret it and get in shape with water aerobics!


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People often ask me, or rather more accurately tell me, that "TRIZ sounds great for engineers but it wouldn't be useful in my field of work, would it?".
I found this interesting example, not of an initiative that actually used TRIZ, but one which contains all the conceptual elements of TRIZ 'Ideality' [calculated as Benefits divided by the Costs and Harms] and more importantly comes to a paradigm shattering conclusion.
Habitat conservation has previously been seen as an expensive activity where conserving sites of importance for biodiversity conservation is simply of academic interest but the benefits were poorly understood while the costs were growing exponentially.
A recent Danish funded piece of research followed a very similar route to one of our TRIZ problem solving workshops:
They identified four (ecosystem service) benefits:
- carbon storage
- provision of freshwater ecosystem services
- option value
- cultural value
for which they estimated the financial value of these ecosystem services.
Then they assessed the costs of conserving them…
To cut a long story short (you can always read the report) their findings suggest that:
Overall, the aggregated values for the network of priority sites performed significantly better for all four ecosystem services:
- carbon storage is significantly higher
- would deliver substantially greater freshwater services than other sites
- culturally, they lie in areas of significantly higher linguistic diversity
and the killer conclusion, and title of the paper, that
Conserving critical sites for Biodiversity provides disproportionate benefits to people
This is a powerful first step towards taking into account a total ecosystem view. As a TRIZ practitioner, I would be failing my craft not to recommend that they do not stop half way. They should now:
- Take each of the costs and harms and apply the appropriate Standard Solutions to reduce or remove
- Take each of the benefits and work through the Standard Solutions to maximise each benefit.
- Plot these creative solutions on a nine box analysis sheet and determine what needs to be done strategically and what tactically.
… and don't get me started on the all storytelling methods they could use in order to engage the stakeholders in order to make the changes happen.


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We have been sorting out all our stock to sell in preparation for our next race at Spa in early July. As a result we can offer the following at absolutely rock bottom prices, just to clear.
All the following is original Yamaha clothing, Phase One branded:
Polo in navy blue (Yamaha Speedblock, retailing at £30.99) at £10.00 each (+ £1.99 p&p).
- 15 x XL
- 3 x L
- 1 x M
- 1 x 2XL
Jacket, navy blue, fully lined, (Yamaha Speedblock casual jacket), retails at £76.99, now for only £25.00 each, (+ £2.99 p&p)
- 2 x 3XL (for the coats it is sensible to order a size bigger than usual)
- 1 x XL
- 1 x L
- 1 x M
Please send a cheque for the required amount to Phase One Endurance, Moxhill Farm, Combwich, Bridgwater, Somerset, TA5 2PN. Don't forget to state the size for the garment you wish to order.
Friday, 29 April 2011
Sunday, 10 April 2011
Bol d'Or, Magny Cours, 16th/17th April
Eight Phase One Team members have been incorporated into the Honda TT Legends team for this weekend's Bol d'Or race.
Russell Benney has been appointed TT Legends race manager, and together with Craig Reilly, Lida van Ham and Mike Wain have been working with the team since January.
The team has now completed 24 hours of testing at Darley Moor, Albacete and Magny Cours, and is ready for the 24 hour challenge.
The team's objective is to finish, with any significant result being a bonus.
Follow us on http://www.hondaproracing.com/world-endurance/
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After a series of lawsuits, the National Football League decided to earmark $100 million to study head trauma. However, not a single cent has been spent on medical marijuana research, and that is a shame. At the same time, the hype around the lawsuits has brought significant attention to the prevention and treatment of traumatic brain injuries (TBI) in sports. So, what is the role of marijuana in this story?
First, let us figure out what a concussion actually is.
A concussion is a minor traumatic brain injury caused by a blow or bump to the head. Our brain is made of soft tissue, cushioned by spinal fluid and encased in the protective shell of the skull. When a concussion occurs, the impact can jolt the brain. Sometimes, it literally moves around in the head. Traumatic injuries often cause damage to the blood vessels, bruising, and injuries to the nerves. As a result, the brain does not function normally.
Patients who get concussions may lose equilibrium, fall unconscious, experience headaches and body pain (the result of inflammation, as brain cells swell following the trauma); their vision may be compromised. Tremor and short-term memory loss are also common companions of a concussion.
The anecdotal evidence in favor of CBD—a non-psychoactive marijuana compound also known as cannabidiol—is persuasive. The available research on CBD is limited but promising: numerous studies showed that it could protect brain cells from injury as well as promote cell growth, offsetting chronic traumatic encephalopathy (brain degeneration likely caused by repeated head traumas and linked to depression and suicide). Additionally, CBD is known to have anti-inflammatory properties and relieve pain. These medical benefits are especially of interest to the NFL players: first, studies have shown that THC and CBD are both effective pain relievers, and second, a nonaddictive pain reliever is certainly of interest to a league currently being sued by ex-players for negligent and harmful distribution of opiates.
Some companies recognizing the potential of cannabis are diving into marijuana research in an attempt to make drugs that would prevent brain damage from a concussion before it happens.
While much of the research focused on CBD, preclinical studies showed that its psychoactive friend, THC, might be helpful as well. In 2014, a study by Harbor-UCLA Medical Center in California showed that patients with traumatic brain injuries who had detectable levels of THC in their systems at the time of the accident were less likely to die from brain trauma.
In the light of that, some university researchers have already set out to test a marijuana-based drug.
In 2014, Lester Grinspoon, an Emeritus Professor of Psychiatry at Harvard University, wrote an open letter to the NFL Commissioner Roger Goodell advising him to consider allowing marijuana as a treatment for post-concussion syndrome. He pointed out that although the NFL offered former players $765 million to settle a lawsuit charging the organization "with knowingly concealing a link between pro football and traumatic injury," this huge figure was nothing in comparison to the human toll paid in terms of pain and untimely death among players. The professor urged the NFL to look closer at marijuana and fund research to determine whether the plant can help.
Earlier this year, the Realm of Care supporters, including an ex-Baltimore Ravens tackle Eugene Monroe and former NFL quarterback Jake Plummer, initiated the meeting with the NFL's medics in order to discuss CBD-based treatment and cannabis testing policies for players. The NFL Player Association said that both parties to the Policy (the NFL and the NFL Player Association) sought guidance from the independent medical professionals who administered the policy, and no change in the substance's status as a Schedule I drug had been recommended by those medics. And, of course, no real plan was set forward because of the collective bargaining agreement listing marijuana among the NFL's banned substances.
The NFL and NFLPA have a staunch policy prohibiting cannabis use. No player can cross the NLF's allowable limit of 35 nanograms of activated THC per milliliter of urine. In 2014, the league and the players association agreed to alter the policy are raise the THC threshold from 15 nanograms to 35 nanograms per milliliter. Players are tested only once in the offseason, but violators could be subjected to additional random tests and penalties that range from fines to 1 year of suspension without pay.
Besides the NFL, there is no other professional league where athletes could get popped for marijuana. For comparison, the Olympics' allowable limit is 150 ng/ml, and violators face suspensions ranging from 3 months to 1 year.
For many professional players, pain is a constant companion. The headaches and body pain that accompany a concussion are the result of inflammation, as brain cells swell following the trauma. As much as sportsmen try to avoid painkillers, there are times when they need the assistance.
Pills and injections are the norm in professional sports, as well as long-term concerns. Players have often talked about the unwelcome side effects, such as depression, lethargy, the risk of opiate addiction.
A 2011 study by researchers at Washington University in St. Louis found that more than half of all retired NFL players used opioids during their career, and 71 percent of them reported abuse. Furthermore, unlike marijuana, opioids—morphine, oxycodone, heroin—can cause a fatal overdose.
Certainly, not every player experiences terrible pain, but with the heightened awareness of the long-term damage football does to the mind and body, many ex-sportsmen are anxious in searching for alternative ways to not only treat injuries but also prevent the onset of additional symptoms.
Plummer and Monroe, as well as many other NFL players, believe in the efficacy of CBD as a powerful and safe painkiller and think that the league players should be allowed to use it. That is why they have teamed with CW Botanicals and its non-profit partner, the Realm of Caring, in an effort to raise over $100,000 to fund initial studies of CBD. CW Botanicals is the Colorado-based company manufacturing a widely-known hemp extract called Charlotte's Web. It is legally confirmed that the product has no more than 0.3 percent THC, so the NFL players can use it with no fear to test positively.
Of course, the best way to ensure any treatment is effective and safe is to put it through the FDA's drug approval process. Currently, a few pharmaceutical companies are trying to promote drugs that harness the neuroprotective properties of CBD. For example, Kannalife is raising B funding with the goal to launch clinical trials on CBD and CBD synthetic. GW Chemicals announced positive results in the phase III clinical trials of Epidiolex, the CBD-based medicine for treating Dravet syndrome.
Plummer hopes that football players will soon be armed with enough clinical evidence of the benefits of CBD to initiate a discussion with the NFL. And he hopes for a real change, a change that will allow players to choose the safest and most effective treatment for themselves.


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text: Brenda is a chef, restaurateur, cooking school teacher, food presenter and organic food pioneer who has made food her life's work. She has owned and operated three restaurants including Mondo Organics, the first licensed organic restaurant in Australia. Brenda is passionate about wholefoods and tending her patch of earth on Tamborine Mountain, which she's transformed into a kitchen garden and orchard. She shares her love of cooking with wholefoods in her first cookbook Wholehearted Food.Back to Booking Page


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Personally, I fell in love with the story after watching the film version for the first time. Since then I have seen the movie countless times and have seen the production in Broadway. If you have not, go see it on Broadway. It is definitely one experience you will never regret.
The music itself is so well crafted that it pulls at my emotions no matter how many times I listen to the songs. Perhaps it is because I have a personal story entwined with each and every one of them, or perhaps it is because the story of the Phantom is simply so memorable. Whatever the reason, I know I will never get tired of listening to these songs.
And for the fellow Phans out there who don't know about it yet, there is a sequel by Andrew Lloyd Webber currently on West End called Love Never Dies. The soundtrack is just as haunting, but I have heard the plot has received bad reviews. Perhaps the composer's major revisions that took place not too long ago changed the opinions, but nonetheless I plan to go see it on Broadway.


text:
March 13, 2013
Communications and Marketing
(603) 641-7242
As Argentina's Bergoglio becomes Pope Francis, Saint Anselm College joins in the world-wide celebration.
The news on campus of white smoke pouring from the Sistine Chapel evoked cheers amid the ringing of the bells. Crowds gathered in Campus Ministry among other places, where faculty, staff, students, and Benedictines watched the news, waiting together for the appearance of Pope Francis.
Fr. Anselm ran to the Abbey Church to trigger the pealing of the Alumni Hall bells when the news was announced.
"It was a really cool moment to know that every one around the world was finding out at the same time," said Molly White, class of 2015.
For many students this is the first opportunity they've had to understand what a papal transition signifies for the Catholic faithful. Sue Gabert '91, Director of Campus Ministry said, "Among students there is alot of interest in this election and a desire to be connected in a new way, even those who aren't Catholic are intrigued."
"Students are hopeful and seem to see in Pope Francis I a sense of humility and a desire to be connected to the people which is important to them," said Gabert.
According to news reports, the new pope took the name Francis in honor of St. Francis of Assisi because he is a lover of the poor. In the college's live chat, Gabert said that some noted quotes associated with St. Francis are "Always preach the Gospel and if necessary use words," as well as "God speaking to Francis saying 'Francis rebuild my Church.'" She suggests those might be symbolic of Pope Francis' papacy.
While the future is papacy is still unknown, many are recognizing the pastoral tone of Pope Francis' history coupled with his name choice as signifying his more pastoral approach. "Saint Anselm students are very aware of our duty to the community," said White. "By taking the name Saint Francis, it may spark a renewed devotion to service."
Asked about Pope Francis, student Jimmy Leonard '15 noted that the tone, tenor, and emphasis on service is exciting. "It's a big message in taking the name Francis."
The college will celebrate Mass for Pope Francis on Wednesday, March 13 at 9 p.m. in the lower Abbey Church.
Saint Anselm in the News
WMUR-TV: "Catholics preparing for Pope Benedict XVI's retirement."
Interview with Fr. Jonathan DeFelice, O.S.B.
Union Leader: "Pope's resignation stuns NH Catholics."
Interview with Fr. Jerome Day, O.S.B.
New Hampshire Public Radio: "New Hampshire Catholics And Their Hopes For A New Pope."
Interview with Fr. Benedict Guevin, O.S.B.
Union Leader: "Kinship with Pope elates Latinos."
Interview with Prof. Christine Gustafson, Ph.D.
- Bro. Isaac's blog: "On Electing Popes and Abbots"
- Catholic News Service
- "Papal Transitions – Backgrounder" (PDF/376KB)


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The month of Muharram and the day of Aashura enjoys special virtues that other days do not possess.
Those aspects regarding Muharram and Aashura which are proven from Quran, Ahadeeth and from the views of the research scholars have been mentioned. have been mentioned in this book by Molvi Fadhlur Rehmaan Azmi. Further more those facts that are incorrect and baseless but has become famous among the Ulama and Laymen have also been highlighted so that one refrains from accepting them and mentioning them.
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With over three decades of experience providing the homes and businesses in and around Woodbury with excellent and dependable heating and cooling repair and installation service, we've had more than our fair share of positive reviews. Be sure to see what our satisfied customers are saying by visiting our reviews page.
Woodbury Heating, AC Repair and Installation Services You Can Count On
With 30+ years of experience keeping the homes and businesses in Woodbury, MN comfortable and filled with the cleanest air we can, you can count on us to provide you with speedy, dependable service. We offer expert installation and repairs, and ongoing service and checkups to keep your system running as efficiently as possible.
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Scugnizzo Ristorante transports you and your guests to Italy for a night of fine cuisine in a warm family-feel surrounds. Menus can be tailored to ensure all taste buds are catered for.
Carmine was born and grew up in Naples Italy he moved to London to advance his career and experiences. This is where he met is wife and they moved to Australia in 2006.
His dream and passion has always been about food and opening Scugnizzo his first restaurant was a culmination of hard work and immense passion.
Carmine serves up the warmth and love of Naples in his dishes and takes you on a tour of real Italy.
If you would like a tailored menu for your special day please contact us and Chef Carmine will work with you to create your perfect day.
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Institut für Informatik und Computational Science
Automatic code generation is an essential cornerstone of today's model-driven approaches to software engineering. Thus a key requirement for the success of this technique is the reliability and correctness of code generators. This article describes how we employ standard model checking-based verification to check that code generator models developed within our code generation framework Genesys conform to (temporal) properties. Genesys is a graphical framework for the high-level construction of code generators on the basis of an extensible library of well-defined building blocks along the lines of the Extreme Model-Driven Development paradigm. We will illustrate our verification approach by examining complex constraints for code generators, which even span entire model hierarchies. We also show how this leads to a knowledge base of rules for code generators, which we constantly extend by e.g. combining constraints to bigger constraints, or by deriving common patterns from structurally similar constraints. In our experience, the development of code generators with Genesys boils down to re-instantiating patterns or slightly modifying the graphical process model, activities which are strongly supported by verification facilities presented in this article.


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McComb v. NorfusAnnotate this Case
The Supreme Court affirmed the judgment of the trial court concluding that Plaintiff's wrongful death action was barred by the exclusivity provision in Missouri's workers' compensation statutes, Mo. Rev. Stat. 287.120.
Edward McComb died while driving a vehicle for his employer. Plaintiff, McComb's widow, brought this suit against McComb's supervisory co-employees (collectively, Defendants). The trial court granted summary judgment for Defendants. On appeal, Plaintiff argued that whether McComb's death was attributable to his employer's nondelegable duty to provide a safe workplace was a question of fact for a jury to decide, thus precluding summary judgment. The Supreme Court affirmed, holding that Plaintiff failed to establish that Defendants owed McComb a duty separate and distinct from his employer's nondelegable duty to provide a safe workplace, and therefore, summary judgment was properly granted under Parr v. Breeden, 489 S.W.3d 774, 778 (Mo. banc 2016) and Peters v. Wady Industries, Inc., 489 S.W.3d 784, 789-90 (Mo. banc 2016).


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US and UN condemn killing of Palestinian boy in Israel
The US and UN have condemned the abduction and murder of a Palestinian teenager in Israel, which sparked fierce clashes in East Jerusalem.
US Secretary of State John Kerry called it "sickening" while the UN demanded justice over the "despicable act".
Mohammed Abu Khdair, 17, was seen being forced into a car early on Wednesday.
Palestinian leaders expressed outrage over the killing, amid claims it was in revenge for the murder of three Israeli teenagers.
Palestinian President Mahmoud Abbas accused Jewish settlers of killing Mohammed Abu Khdair, calling for the "strongest punishment against the murderers if [Israel] truly wants peace".
Agence France-Presse news agency quoted the militant group Hamas as telling Israeli leaders: "Our people will not let this crime pass... You will pay the price for these crimes."
Israeli leaders also condemned the killing, pledging a full investigation.
Prime Minister Benjamin Netanyahu said it was "despicable" and that he had ordered police to work "as quickly as possible to find out who was behind the heinous murder of the youth".
He called on both sides "not to take the law into their own hands".
John Kerry said there were "no words to convey adequately our condolences to the Palestinian people".
Analysis: Yolande Knell, BBC News, Jerusalem
The Israeli police insist they are taking the case of Mohammed Abu Khdair seriously and that a thorough investigation is under way. They said they began a search for him as soon as he was reported missing.
Most Palestinian residents of East Jerusalem have already made their minds up about the motivation for the murder.
Tensions are now set to rise again particularly with a funeral expected to take place on Thursday. Locals say they are worried this death could trigger a new cycle of violence.
Jerusalem's vicious cycle of violence
He said: "All parties must do everything in their power to protect the innocent and act with reasonableness and restraint, not recrimination and retribution."
A spokesman for UN Secretary General Ban Ki-moon said that "the heinous act by enemies of peace aims to further entrench division and distrust and to widen the conflict. It must not be allowed to succeed".
UK Prime Minister David Cameron said he was "appalled by the murder of a Palestinian teenager".
The family of one of the three murdered Israeli teenagers also issued a statement condemning the latest killing.
"If the Arab youth was murdered because of nationalistic motives then this is a horrible and horrendous act," the statement from the family of Naftali Frenkel said.
Israeli police have urged caution over the motives for the killing, saying they are still investigating.
Rubber bullets
Clashes erupted outside the teenager's home in the Arab district of Shufat in East Jerusalem after news broke of the discovery of the body.
Protesters threw stones at officers, who responded by firing sound bombs, tear gas and rubber bullets.
At least 35 people were injured by the rubber bullets, reports said.
The family of Mohammed Abu Khdair have confirmed the body found on Wednesday in a forest near Givat Shaul, in the western outskirts of Jerusalem, was his.
The body was partly burned and bore marks of violence.
Witnesses said he was abducted near his father's shop in Shufat.
A relative said he saw two men approach the boy and ask for directions before bundling him into a car.
Witnesses wrote down the car's number plate and police are examining CCTV footage.
The killing came a day after funerals were held in the West Bank for the three Jewish seminary students whose bodies were found near the city of Hebron on Monday, two-and-a-half weeks after they were abducted.
Scores of Israelis had angrily protested in Jerusalem after the funerals, some yelling "death to Arabs".
Israel's military said it was investigating reports that soldiers had posted calls for revenge on Arabs on social media networks, saying if true it would treat the matter with utmost severity.


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Back in my younger days I was a massive stoner.
All day, every day.
When I was 18, I got busted sitting in my truck back off the road taking a bong hit out of this wicked cool, 3 stage, ice cooled, monster fucking bong I had just bought a week before.
All I had was a couple of hits of some nasty homegrown shit. This was in Oregon at the time and they had sort of decriminalized so it wasn't some major jail time thing anymore.
It cost me a hundred bucks, the cops took my bong, the two freakin' hits of home grown and even the plastic lunch tray I had swiped from school that I used to keep things nice and tidy with. Back in those days twigs and seeds were the norm. Nasty fucking Mexican weed was about all you could get most of the time.
Now they come out with this shit.
Costco to Offer Wholesale Marijuana by Summer
REDMOND WA- Kirkland based wholesale megastore Costco has announced plans to offer bulk high grade marijuana under their flagship Kirkland Signature brand in all 237 Washington locations.
The marijuana will be exclusively purchased from the Suquamish Tribe, which is currently awaiting federal approval to begin production on.
Tribal gaming commissioners met with Costco executives more than 3 months ago to work on a tentative deal.
Kirkland signature hopes to add marijuana to its laundry list of goods including baby clothes, shampoo and dad shoes by the end of June.
They have shit out there now that'll fucking paralyze ya if you ain't used to smokin'. I'm not joking either.
It's been years since I have been able to even take one damn hit because every fucking job I have had for the last twenty five years has had drug testing.
I'm not losing a job for that, I have a family to support.
It really fucking bites that the state I live in made the shit legal last year but the fucking job still has the drug testing horse shit.
It's probably just as well, the last time I took a bong hit, it was some of that Killer Green Bud, Skunky shit and ten minutes later I was completely immobilized and drooling in my lap.
The shit's like Elephant Tranquilizer compared to the garbage I grew up on.
So if you are a stoner these days you are probably used to it and now you will soon be able to go buy it in bulk!
While you are there you might as well stock up on munchies too.
Just remember, don't bogart that joint man.
H/T to my most excellent buddy Steve for sending me the link.


text:
The weather has turned in London, and while it ain't exactly warm at least the sun is out which makes the transition from summer in Sydney not as tough as it was in January when I was last here.
This is something of a fact finding mission. A few chats with the right people, organising bureaucratic stuff for our new business which will launch here mid-year; looking at office space etc etc. In the process I've been fortunate to visit a number of media shops. One of the most interesting has been the Daily Telegraph's newsroom. I gotta say it's impressive. A lot has been written about it in the UK media, so Google it.
A bit of gossip: the day before I was there Ron Walker had been in the building, sitting in on news conference, touring the floor, hobnobbing with the big cheeses. Does this have something to do with the imminent newsroom moves at the Sydney Morning Herald and The Age? Is it about digital integration or commercial real estate (the Telegraph has a uniquely large floor space, something which is hard to come by)? Or perhaps he was just dropping in on some mates?
There's a fair bit that Fairfax could conceivably learn from the Daily Telegraph's experience, but I wonder if the Chairman of the company is the right person for Fairfax to have on the case?


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This post may contain affiliate links. Please read my disclosure.
These green beans are braised in coconut milk and chili garlic sauce until melt in your mouth tender. So tender…
We all have learned to love those cooked veggies that retain their crunch, but sometimes you need a little change. Don't get me wrong, I love those crisp veggies.
BUT, I also love a green bean that is soft and tender, filled with flavor from being slowly cooked in whatever tasty liquid you're using that day.
The flavorful liquid for these braised green beans is made from coconut milk and chili garlic sauce. For an extra kick, add some curry powder to your cooking liquid.
The key to getting soft, melt in your mouth beans is to cook the beans on low heat for an extended period of time, typically 25-45 minutes, depending on your consistency preference. I cook the beans for 30 minutes in this recipe, but more time can be added if you prefer an even more tender bean.
Easy to make and incredibly delicious, this is a great way to get your servings of veggies!
Coconut Milk
I discourage the use of low fat coconut milk in this recipe. The lighter versions do not separate to give you the coconut cream, which is what makes this recipe work well, so, use low fat at your own risk!
Be sure to stir the coconut milk before using. The coconut cream typically separates from the liquid and must be re-combined to use in this dish. Do this by shaking the can vigorously, or pouring the contents in a bowl and mixing them together.
Now, how easy was that?
Did you make this recipe? Leave me a comment below and let me know what you think!
Braised Coconut Milk Green Beans with Chili Sauce
- 1 tbsp. coconut oil
- 12 oz. green beans ends removed
- 1 tsp. salt
- 1/2 tsp. pepper
- 1 1/2 tbsp. chili garlic sauce
- 5 oz. coconut milk full fat
- Snap the ends of your green beans off and break them in half to make the pieces bite sized.
- Heat coconut oil over medium heat and add green beans. Cook for 1-2 minutes.
- Add salt and pepper and cook another 5 minutes, stirring periodically.
- Add coconut milk and chili garlic sauce. Bring to a boil, reduce heat and simmer, covered, for about 25 minutes.
- Add additional salt and pepper to taste, cover and simmer another 5 minutes. Serve.
NOTE: Be sure to stir the coconut milk before using. The coconut cream typically separates from the liquid and must be re-combined to use in this dish. Do this by shaking the can vigorously, or pouring the contents in a bowl and mixing them together.
[nutrifox id="30929″]
Did these green beans melt in your mouth? What variations did you use for this recipe? How did it come out? Do you like your green beans soft or do you prefer a crunchier bean?


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It's not "let's strap a rocket on this thing"-crazy, but...it's still completely crazy.
The man in the aero suit is Eric Barone, also known as "The Red Baron." And he just broke his own previous mountain-bike world speed record with this 138.75 mph (223.3 km/h) run. That he does it on snow just makes it seem all the more impressive:
His old record wasn't exactly slow at 222.23 km/h—or 138.08 mph.
Still, Francois Gissy's Ferrari-destroying 207-mph run makes The Red Baron's mountain jaunt seem gentle and sane by comparison:
via: PopMech


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Co-directors Robert Rodriguez and Frank Miller reunite to bring Miller's visually stunning "Sin City" graphic novels back to the screen in SIN CITY: A DAME TO KILL FOR. Weaving together two of Miller's classic stories with new tales, the town's most hard-boiled citizens cross paths with some of its more reviled inhabitants. SIN CITY: A DAME TO KILL FOR is the follow up to Rodriguez and Miller's 2005 groundbreaking film, FRANK MILLER'S SIN CITY.
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Patterns of the City flags caught my eye as soon as I arrived at the central station in Belfast. The project has recently taken over the city with some 400 flags installed all over to welcome visitors and enhance local knowledge. The twelve designs highlight specific places and objects in Belfast that visitors or citizens might overlook, with themes being determined through community workshops with young people throughout the city. The flags serve as a vibrant and unique representation of Belfast and create a feeling of celebration and pride in a city that is really trying hard to overcome its sordid past.
Flax Fox, Belfast
I am self-admittedly really bad at keeping in touch. I twitter/facebook people sometimes, I email even less and I do not send enough postcards. I would really love to send more handwritten notes home but it just doesn't happen as often as I'd like considering that after four months of travel I still haven't made it through the list of people I intended to write. But, when I find good postcards I do take the opportunity to send a little love home. Such was the case when I came upon Flax Fox and their beautiful postcards at St. George's Sunday market. Danielle Morgan and Bridget Farmer are the duo behind the sceenprint designs which are sold as prints and transferred to tea towels and postcards. The whimsical illustrations are so remarkably Belfast that I fully intended on keeping a couple of the postcards for souvenirs but I really am THAT behind at my correspondence and used them all so will have to order a print or two for myself when I get home.
website: www.flaxfoxdesigns.com
etsy shop: www.etsy.com/shop/flaxfox
twitter: @flaxfoxdesigns
Designgoat, Dublin
Right, I've been gone from Dublin for a week already so this will have to be the last post (for now) in my awesome people I met in Dublin* series. It comes a little late as I didn't have wifi for the few days I was in Castlerock and now the connection in my Belfast hostel is practically nonexistent so I snuck away to a coffee shop that will not be named to write this post. Hardly fitting as I met the guys behind Designgoat at Brother Hubbard, a rad new locally owned cafe that just opened in Dublin. Even more, they were the designers behind Brother Hubbard and my local haunt for the week, 3FE (pictured). Cian and Acky are industrial designers based in Dublin with really impressive moustaches. Together they make up Designgoat. I am blown away at how these guys are pushing the boundaries of their craft and at their contribution to the Dublin creative community so early into their respective careers. I especially love how they are combining their design background with their passion for food, recently curating a dinner for the Edible series at the Dublin Science Gallery. These gorgeous photos of their Taste of Dublin event are from my good friend Al. Wish I could have been there.
*I also met a lot of other awesome people in Dublin, I've only featured a handful of the creative type ones with websites...sorry other friends!
website: www.wearedesigngoat.com
blog: designgoat.blogspot.com
twitter: @wearedesigngoat
Peter McDonagh, Dublin
Sometimes the world is too random to be random. I met Peter McDonagh through Al while I was in Dublin. We had enough in common already with regards to graphic design and our work in the coffee industry but then we discovered a few really bizarre connections. Peter grew up with my former Irish roommate and is pen pals with another completely unrelated friend's fiancé from Nova Scotia. What a small world.
All that aside, Peter is a talented photographer and graphic designer. He's just finishing off his degree in Dublin with a thesis on coffee packaging. His current work is brilliant and I'm looking forward to seeing more of it as his career progresses. And, with all of our random connections, I also look forward to our paths crossing again.
twitter: @petermacdee
Al Higgins, Dublin
Annabelle in Dublin last week, largely due to the kindness and generosity of the people we met. I'll start with this man. I can honestly say my trip around the world would not have been the same without having encountered Al Higgins along the way. Al is an extremely talented photographer and a gifted foodie who took us under his wing in Dublin. He provided us with a long list of recommendations for the best food and drink in the city, introduced us to his wonderful community of friends, shared many conversations over many pints and coffees, and charmed us with one of the best deadpan sense of humours I've known. It's these types of people that make travelling the best and the worst. The best for the chance to know them, the worst for having to leave them behind. Check out his photos and get to know this man. Look forward to many more adventures with him down the road.
Also, the handsome man at the end is Tom Cooney, an extremely talented musician. We had the pleasure of spending time with him and his lovely wife in Dublin as well. Too many good people in this city.
portfolio: www.alhigginsphotography.com
blog: alsphotos.tumblr.com
twitter: @fajitasgtr
Also, the handsome man at the end is Tom Cooney, an extremely talented musician. We had the pleasure of spending time with him and his lovely wife in Dublin as well. Too many good people in this city.
portfolio: www.alhigginsphotography.com
blog: alsphotos.tumblr.com
twitter: @fajitasgtr
Posted by Unknown at 9:18 AM Location: Portadown, Northern Ireland
Labels: awesome people in dublin, food, inspiration, ireland, journal, photography, travel 2 comments
National Print Museum, Dublin
Annabelle and I spent a bit of time in the National Print Museum in Dublin. Their collection and assortment of working presses and typesetting machines was incredible but I was a bit disappointed with the lack of printed material, both on display and to purchase. Nonetheless, it's a beautiful old space with lots to look at for anyone who likes type as much as we do.
Posted by Unknown at 4:28 AM Location: Dublin, Ireland
Labels: graphic design, inspiration, ireland, journal, museum, recommendations, travel, typography 1 comments
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With an opportunity to dictate line matchups and find favorable times to get his four main defensive starters some key rest, Chicago Blackhawks head coach Joel Quenneville appears to be inserting defenseman Trevor van Riemsdyk back into the lineup for the first time since November.
"I thought he came out into the team out of the blue, outstanding at the beginning of the season for us," Quenneville said at his press conference following the Blackhawks' Monday morning skate at the United Center. "I think he adds another dimension to our back end. He's got a real good patience level with the puck."
The rookie defenseman was limited to just 18 games during the regular season before a fractured kneecap sidelined him back in November. He was efforting toward a comeback in a rehab stint with the Rockford IceHogs earlier this spring when he injured his wrist. He has been skating with the team for the last few weeks, but until now Quenneville has not put him in the lineup.
"I've been doing all that I can to get ready and just be mentally prepared for this," van Riemsdyk said after practice. "Obviously, there's a lot of experience in this room that can help you get ready. It's been a fun experience to be part of it this time and not just watching on TV."
Even with the rust of not having played an NHL game in seven months, Quenneville is confident that the rookie has what it takes to jump back in and make an impact immediately for the Blackhawks.
"He is very patient," he said. "[I've] got a lot of confidence in his game. He has good play recognition. [The] minutes that he's going to be coming in and replacing are minimal."
In all likelihood, it will be David Rundblad that van Riemsdyk will replace in the lineup for the Blackhawks. The team has mixed and matched defensive pairings throughout the postseason, and they've been forced to continually adapt as Michal Rozsival sustained a fractured ankle during the team's second round victory over the Minnesota Wild.


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Highlights of the October 9 Board of Education Meeting
The October 9 Board of Education meeting featured a presentation on the design concept for the kindergarten school at the Sullivan Center. Elementary South Principal Dr. Jill Martin and kindergarten teachers talked about the history of Hawthorn's growth and reviewed the input teachers provided for the design of the new school.
DLR Group Principal Jason Lembke said he followed the teachers' recommendations, incorporating collaboration, innovation, spaces for students to be social, and flexibility into the building's design. He mentioned that design team members had toured the Barrington Early Learning Center, Washington School in Mundelein, and the Ann Reid Early Childhood Center in Naperville to look at a variety of design options.
Lembke said that after looking at different design possibilities, the team selected a concept called "The Flower" as the best choice for Hawthorn. The flower scheme is comprised of "petals" featuring classrooms with operable partitions that provide extensive flexibility. The interior of each petal includes four classrooms, a Maker space (that could also serve as an additional classroom), two small group spaces and a dedicated pull-out space for things such as special education.
Two petals are proposed for the first floor of the new facility, which will be located on the northeast side of the Sullivan Center. That floor will also include a multi-purpose room (cafeteria), art studio, an administrative area, that also will serve as a storm shelter, and a sensory room with external access. The second floor will feature two petals, an active play space, and a staff collaboration space.
Thomas McGrath with LAMP Incorporated discussed the budget. The cost of the project is projected at $12,121,289, with a road site allowance of $150,000. He said the project could go out to bid as early as next March and construction could start as early as June.
Superintendent Nick Brown discussed the approval process. He said that a presentation would be made to the Park District on October 10. The Park District, the Village and Regional Office of Education will all need to approve the project. Permits will need to be obtained from the County. Wetland credits also need to be purchased. The formal recommendation for schematic design approval will be made at the October 23 meeting.
Mr. Brown also provided an update on student placement for the Cuneo Farms development. Regarding which schools the children from this new subdivision will attend, he recommended Elementary North and Middle School North as best suited to accommodate this new population. Final action will be made at the next board meeting.
Due to time constraints, a discussion on public comments collected in the survey about the Educational Facilities Master Plan was tabled until the next meeting.
In her president's report, Sonali Patil mentioned that October is National Principals Month. She thanked Hawthorn's principals for all the work they do.


text: The underground Posted on October 9, 2014September 1, 2014 by Paul Cahill 1. Quick afternoon photo shoot in London 2. Trafalgar square in London 3.Nikon V1 Share this:TwitterFacebookBufferPocketEmailRedditSkypeLike this:Like Loading... Published by Paul Cahill History lover, observer, occasional photographer, husband, father, & apostles creed believer. Think. View all posts by Paul Cahill


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Just wanted to report on a new product we have tried recently. I have received a box from Bzzagent for a new campaign for babies – new Gerber Lil Bits food.
I think the concept is great – perfect for my baby! Basically, they use real fruits in pureed form, and then they add little fruit pieces to the puree, so the texture is not homogeneous, but your baby will be able to try out new textures, and it will be easier for the baby to learn to eat new foods trying out pieces of soft textured fruits.
I am not sure if my particular baby liked the food that much, but she is kind of moody with what she eats. She is not easy to feed in that sense, and may like the food today and hate the same exact food tomorrow, so it is not a big sample to tell whether it is great food or not.
We have some coupons we have got from Bzzagent as well, so we may try some other flavors of Lil Bits as well.
This is the perfect time for us to try these, as our baby is just learning these textures now, so the timing couldn't be better than now to try them. I will probably grab some more of those when I go shopping next time, as she needs more food daily, as you can imagine.
I generally feed her with homemade food at home, but when we are on the go, we have store bought food more often as it is easier to carry around on the go than worry about a million containers to bring.
I have to say that I try to get her Gerber most of the time when I buy her food. The main reason is that I like the texture of their products. The purees are always very fine, and this baby has had some trouble swallowing foods at the beginning. She is doing better now with foods, but I still try to serve her more foods made out of strained and finely blended ingredients. I cannot achieve that with my blender when I am serving her meat, so I do rely heavily on Gerber meats for her. I just need her to eat at this point, so despite the fact that I always prefer homemade food, I do need her to be able to eat food, so I do use store-bought food for this baby quite a bit.
Disclaimer: I have received Gerber samples to try for free. I am providing an honest review of my opinion about the product.


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The power supply in one of my servers died. After a few checks it seems it didnt gave enough power to my harddisks
A normal solution would be a new PSU but i can't seem to find a one that has a power cut and the cables for the PC at the same side
This is the PSU, antec sl300xrp
This is the server, the room is limited and the PSU needs to be in the right bottom corner
Any suggestions what to do? and if this kind of PSU is still being made?


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Welcome to goldsmith Liat Aviram's online jewelry store.
You can choose from a wide variety of luxurious, hand-crafted jewelry set with precious gemstones. Rings, necklaces, special bracelets and designed earrings, all made from 24-carat gold plated brass or silver and filled with endless happiness and joy.
Great effort was put into creating the online store, so that you can benefit from an enjoyable shopping experience. We hope you find the jewelry you seek with maximum comfort and ease.
The jewelry of your choice will be sent you free of charge via Israel Post, elegantly giftwrapped and ideal as a gift for your loved ones.
Just so you know! All jewelry can be ordered in either silver or gold.
Welcome to goldsmith Liat Aviram's online jewelry store.


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HONK Board of Directors
Doug DeLay
Board President
Shawn Masters
Board Vice President
Dan Burr
Board Secretary
Derrick Theetge
Board Treasurer
Fr. Joe Gallenstein
Board Member
Robert LaMothe
Board Member
Molly Navin
Board Member
Yvonne Rich
Board Member
Mary Ann Stewart
Board Member
Korey Yelton
Board Member
HONK Counsel
Michael Ruberg
HONK Legal Counsel
Fr. Jack Goeke
Founder, HONK Advisor


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Whether designing and installing a new system, repairing existing systems, or retrofitting older systems, Tri-State Electrical Contractors offers extensive expertise with even the most complex automation and control systems. Our technicians are proficient in both AC Variable Frequency Drives (VFDs) and DC motor controls, servo systems, SCADA (supervisory control and data acquisition), PLC (programmable logic controller)programming and much more.
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Copyright © 2019 Tri-State Industrial Group. 7608 N Harvey Avenue Oklahoma City, OK 73116 USAAll Rights Reserved. Website designed by myheartcreative and managed by Webvis CMS


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MilfHunter Tea for two
Download Video
MilfHunter Tea for two : We were scoping out studio space when this cute blonde came up to us. She was a little forward and out for revenge. Laura was her name, and she wanted a picture with a hot guy to get back at her cheating husband. She'd given us her phone to snap a few pics. Laura reached up to kiss Tony on the cheek. Tony had to make it more personable, so he made contact with her lips and grabbed a hand full of ass. This frisky blonde loved the attention and started to heat up. We told her we were professional photographers, and she came back with us to get some real pictures done. Once back at our spot she was impressed by the set up and was ready. Tony leaned in practically grabbing her pussy and told her we could make her husband really jealous. This eager beaver didn't hesitate to undress in font of us for the shoot. Laura was commando with nothing on under her dress. Her tight package was a sight to see. Once she was in her sexy outfit, Laura went right into pose mode. But she took the shoot to the next level as she bent over and let Tony lick her mother peal. Laura was a wild one and let Tony put it on her. She loved his cock as she creamed on it. Laura was so into the action, she let Tony blast her in the face with his man cream to make sure the revenge was as sweet as could be.


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The next interview from an Art of the State artist is with Ira Upin. It was hard to ignore Ira's piece at the exhibition. Not only is it right next to mine, it's huge, colorful, and dominates the room. It totally makes me think of a reggae album cover and I love the graphicness of it. It's in your face whether you want it there or not. Really great! You can find more work on Ira Upin's website and of course, see his painting, Police State, at the Art of the State: Pennsylvania 2015 exhibition at the State Museum of PA.
1. How did you get started in your craft? (using your media)
I started painting with oil paints as a kid, through high school, undergrad and graduate schools. It was still the traditional medium to use starting for me in the 1950's and the more I used it the better I became at it. In the 60's I added acrylics to my repertoire but mostly for flat color or patterns. In the 80's I used tar as a medium that presented itself during my years as a contractor. But in the end I find oil paint to be the most voluptuous product because of it's creamy, workable, texture, it's range of colors and it's physical capacity for transparency or opacity.
2. What has been inspiring/influencing your work lately?
I have always been a narrative artist with occasional forays into abstraction. This statement encapsulates most of what I do: The two constants in my work have been the narrative and the intensity of the visual. I want the viewer to be intoxicated and perplexed by how I make my paintings and intrigued by the stories I am trying to tell. I'm interested in human dynamics whether they be social, political, or emotional.
With this statement in mind my inspiration is consistently a random series of reactions to things that occur around me personally or things that happen in the world at large. Then I try to create the aura of a story, a psychological or emotional realm of thought or feeling. I don't think there is any past or present to what inspires or influences me. For better or worse it has been pretty much coming from the same place my whole life.
3. Who are your favorite artists in your field?
In no particular order – Chuck Close, Francisco Goya, Anselm Kiefer, Gilbert & George, Robert Rauschenberg, Andy Goldsworthy, Lucas Samaras, Kenny Scharf, Gregory Gillespie, Phillip Harris, David Wojnarowicz, Neil Jenney, Martin Puryear, Antony Gormley, William Wiley, Tony Berlant, David Bates, Jim Nutt.
4. What is your favorite customer quote or story?
I guess the best story would have to be when my father who was an electrical contractor in Chicago was doing a job for an attorney named Jerome Torshen who was legal council to Chicago's 1st Mayor Richard Daley. Seeing that Mr Torshen collected art my father mentioned that his son was an artist and would he be interested in seeing my work. He said sure, I sent him slides and he bought one of my paintings. When I brought the piece to his home he and his wife wanted to see how it looked hung over the mantel. So he just reached up and removed the Picasso drawing that was hanging there and replaced it with my painting. I was in my 20's at the time and I was overwhelmed. It struck me on 2 levels of awareness and emotion. On the one hand my ego soared with the gesture that exchanged my work for a Picasso. But on the other hand I couldn't shake the sense of it all being a commodity to the buyer and all parts were interchangeable. In any event it was a heady experience for a kid.
5. What is your favorite piece of art or fine craft that you own?
We have too many great pieces of art to choose a favorite. We own work by friends like Frank Hyder, Susan Fenton, Anda Dubinskis, Larry Spaid, Mike Ehlbeck, Doug Herren, Lynne Clibanoff, and on and on.


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Necklace length
If you're shopping for a necklace online, it can be hard to decide which length to choose...especially if it's a gift.
Children's necklaces are usually 14 - 16"
Adult chokers are usually 14 - 16"
Collarbone jewellery is 16 - 18"
Please keep in mind that necklaces will hang at different lengths depending on the woman's stature and bulkiness of clothing.
The best-selling range of Morse Code necklaces are designed to sit on the collar bone, measuring 16"+2" extender, with the option of 18"+2".
Natural lava aromatherapy necklaces work best with the warmth of your skin and measure 16".
Glasses holder necklaces measure approx 27".
If you would like a different length of any necklace, or would like to purchase an extra chain/ribbon/cord, simply select the option to 'add to basket' or if the option is not available, contact us.


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Kishore, K and Verneke, VR Pai and Begum, A Sameena (1982) Calorimetric values of composite solid propellants. In: Thermochimica Acta, 54 (1-2). pp. 141-146.
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The calorimetric values of composite solid propellant based on polystyrene, polyphenolformaldehyde, poly(vinyl chloride) and carboxy-terminated polybutadiene were determined using combustion calorimetry in order to assess the uncertainities in their measurements. The dependence of the calorimetric values on various propellant composition was obtained. The stoichiometry of oxidizer and fuel in the propellant for complete combustion obtained experimentally were compared with the theoretical stoichiometry calculated based on the oxidizer decomposition.
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|Journal Article
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|Copyright of this article belongs to Elsevier Science.
|Division of Chemical Sciences > Inorganic & Physical Chemistry
|Depositing User:
|Ali K S
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|21 Aug 2009 07:21
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|19 Sep 2010 05:41
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CakePHP + IOU
August 27th, 2008
The other day I found CakePHP, a really cool php framework which helps me code faster and produce websites with nice features more easily. It was a huge learning curve however and I had to create a whole new website with it before I was able to get the hang of it. So here it is, http://iou.cubedwater.com. Here's what it's about, taken copy&pasted from the website:
Send virtual IOUs to each other!
An IOU (an abbreviation for "I owe you") is a note that is given from one person to another that states that the holder of the IOU is owed something by the person who wrote it. Here at I Owe You you can write out virtual IOUs to each other. It could be for anything from a taco (for the bet the other day?), a date (not recommended) or a hug (recommended) or simply $5.03 (GAS money, baby). You can also write "You Owe Me"s, which is just like an IOU except that the IOU holder is the one who owes the item written on the IOU. When you send an IOU to someone on I Owe You, that person can either accept or deny the IOU. When the IOU is paid, you can mark it as completed. If you want to send an IOU to someone who does not have an account with us, that's fine! You can still create IOUs for that person for your personal record keeping. If you can convince the person to create an account, all the IOUs under that person's name will even be transferred to him or her.
Enjoy the site!
I though about buying a domain for it, but decided not to. I don't feel that this one will give revenue. So why did I create it? We'll, 1, to learn CakePHP, and 2, to reap in the bucks that my friends owe me :p.
Here's a demo screen for ya:
Categories: CakePHP, Web Development


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Some games need very little in terms of introductions and Asteroids is certainly one of those games. Based on the highly successful vector arcade game by Atari, this 2600 version bring home the fun of the arcade along with 66 different variations of gameplay to keep you stuck to your console.
Of course, the game does not have vector graphics and instead has "filled up" asteroids and ships but there is no confusing this game with anything else. As in the arcade, you control a ship that is stuck in the middle of an asteroid field and the only way out is to blow up the asteroids until they are gone. Your ship may have unlimited ammunition but the asteroids also seem to be in unlimited supply because as soon as you are done clearing a wave, more appear and in greater numbers. Hit the asteroids with your lasers only to have larger asteroids split into medium sized asteroids than then split into smaller ones before you can totally blast them away. Of course, you also have hyperspace and shields to help you survive the asteroid field. Of course, you have something else to worry about. Some nasty aliens are trapped in the asteroid field also and they are out to get you. Make sure to blast them before they destroy your ship. Though Asteroids has been surpassed in quality by homebrew programmers (look for Space Rocks), this game remains a classic and one worth having in your 2600 game library.
TrekMD is an MD by day and a writer by night, a lover of all things Atari.
You can visit his ramblings on Twitter at:


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Sage One is a range of cloud based online accounting and online payroll software, offering everything you need to run the accounts and payroll side of your small business or start up. products are specifically designed with small UK businesses in mind and have a number of features that make sure you stay in line with the UK regulations, laws and taxes.
Why choose Sage One?
Work from anywhere
Sage One provides a Cloud-based solution so you can access your accounts system from anywhere, anytime using any Internet-enabled device including laptops, mobiles or tablets. Works on PCs, Macs, Android and iOS.
Collaborate with your Accountant
Share access with your accountant so you can work together online, they can check your progress and make recommendations.
Stay compliant
Whether it's changes to VAT, Pensions Auto-Enrolment or RTI, You're always up-to-date with the latest legislation for your accounts and payroll service
No training necessary
Simple, easy-to-use online software means that previous accounting or payroll experience isn't required to use Sage One.
Your data is secure
Data is protected by bank-level security, so you don't have to worry about taking backups or losing any information.
Free 24/7 support
All Sage One accountancy and payroll packages include:
- Free 24/7 telephone and email support.
- web chat advice available 9am to 5pm, Monday to Friday.
A few ways Sage One Accountant Edition helps you connect with your clients:
- Access your clients' data anytime, from anywhere.
- Access demo data to give your clients an overview.
- Simple set up for you and your clients.
- Save time by reducing data entry.
- One service for you to view any of your Sage One clients.
- Provide a personalised service for your clients.


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Home | Join | Find Service | Courses | Log-In | Help
A hazmat suit and respirator is what Jared Herbert typically wears to work. If passersby ask what he is working on, he tells them he's just cleaning a house. Or taking care of a residential chemical contamination.
He never gives the real reason why his cleaning crew travels in unmarked vans to rip out carpet, scrub air ducts or load furniture into a dumpster.
"We keep it as discreet as we can," he explained. "You want to know that someone has meth in your neighborhood, but you also don't want to know, you know?"
Herbert works as a foreman for Meth Mob, a local Provo decontamination company focused on cleaning "meth houses." He travels across the state to clean all kinds of houses who report having high measures of meth contamination. His crew and asbestos-cleaning crews wear the same garb.
More at source: Herald Extra
Find A Biohazard Cleaning Company Here
Discuss This Article Here
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Crushaders Tech Solution LLP takes into account Local and Global Customer Base, and concentrates on ROI-bringing SEO, SMO and PPC business forms, by delivering comprehensive and cost-effective services and solutions, which tunes a customer's site to be globally accepted and Mobile Responsive. No matter whether you are selling physical, subscriptions or digital products we can set up an e-commerce website for small, medium and large businesses.
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Largest Event of the Year!
June 23-26th during Pekin Days.
Artists reception June 22nd. Public MUST receive tickets, no entry without ticket. Artists and purchasers have tickets included. Tickets go on sale June 1st (on and after only). Call Susan at (701) 797-7053. Tickets $20/Member, $25/ Non-Member.
It is our mission to promote, preserve and perpetuate the arts in North Dakota.
1600 East Century Avenue, Suite 6
Bismarck, ND 58503-0649
(701) 328-7590
(701) 328-7595 (Fax)
Email: firstname.lastname@example.com
Hours of business are:
Monday through Friday, 8 a.m. to 5 p.m.
Closed on National Holidays
Copyright 2014 North Dakota Council on the Arts