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SAMJ: South African Medical Journal
versão On-line ISSN 2078-5135
versão impressa ISSN 0256-9574
SAMJ, S. Afr. med. j. vol.99 no.6 Cape Town Jun. 2009
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
Chris RetiefI; Clara-Maria SchutteII, *; Malcolm Kevin BakerIII
IMB ChB, MMed (Neurol), Department of Neurology, University of Pretoria
IIMB ChB, MMed (Neurol), MD, Department of Neurology, University of Pretoria
IIIMB ChB, MMed (Neurol), FCP MD (USA), DABPN, Department of Neurology, University of Pretoria
BACKGROUND: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco-encephalopathy (CADASIL) is a hereditary autosomal dominant non-atherosclerotic non-amyloid cerebral arteriopathy. The disease was identified in 1993. We are not aware of reports in the literature of its occurrence in South Africa, and we present the clinical and laboratory features of 5 patients with CADASIL.
METHODS: Patients with the characteristic radiological white matter disease and typical features (family history, ischaemic events, migraine or dementia) were evaluated for possible CADASIL by means of clinical examination, routine investigations for strokes, magnetic resonance imaging, skin biopsy electron microscopy, evoked potentials and electro-encephalography.
RESULTS: The clinical and laboratory features of our study largely correlate with reported studies. However, all of the skin biopsies were positive, and the onset of migraine in our patients was considerably earlier. A new finding, to our knowledge, was the normality of visual, somatosensory and auditory evoked potentials.
CONCLUSION: Our study confirms the existence of CADASIL in South Africa, and also suggests that skin electron microscopy is useful, despite recent reports of its low sensitivity, and that evoked potentials in CADASIL are likely to be normal.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco-encephalopathy (CADASIL) is a progressive hereditary non-atherosclerotic non-amyloid arteriopathy first described in a French pedigree, affecting young and older adult patients irrespective of traditional risk factors for stroke.1 The French group, who also localised the abnormal gene to chromosome 19 in their affected patients, coined the term CADASIL.2 The specific abnormality is a mutation of the Notch3 gene, causing damage to vascular smooth-muscle cells. Clinically, patients may present with strokes, migraine, progressive dementia and mood disorders. CADASIL has not been described in South Africa, and we report on 5 South African patients with the condition.
The patients were referred for specialist opinion and were evaluated at the Neurology Department of Pretoria Academic Hospital. No informed consent was obtained since they were seen as part of routine neurology practice and are reported retrospectively. Patients were clinically evaluated, and standard laboratory investigations, echocardiography, carotid Dopplers, electro-encephalography and evoked potential studies, magnetic resonance imaging (MRI) of the brain and full-thickness skin biopsies were performed.
Patients and methods
Case 1
A 60-year-old white woman presented with progressive left hemiparesis, similar to an episode she had experienced 2 years previously but that had resolved spontaneously. Her medical history included mild hypertension controlled by perindopril, and hypothyroidism responding to 0.1 mg of thyroxine. Several individuals in her family had suffered strokes over at least 3 generations. General examination and cognition were normal. She had a mild left hemiparesis with bilaterally brisk reflexes (more on the left), with unsustained clonus and a positive Hoffmann reflex on the left; the tone was increased bilaterally, but sensory and cerebellar examination were normal.
Special investigations, including lipogram, glucose, full blood count, anti-nuclear factor, rheumatoid factor, syphilis serology, HIV serology, protein S, protein C, antithrombin III, activated protein C resistance index, lupus anticoagulant, cardiolipin antibodies, homocysteine, ECG, chest X-rays, transthoracic echocardiography and carotid Doppler, were normal.
MRI of the brain showed widespread white matter abnormalities, especially in the regions of the anterior temporal lobes and the external capsules. Lacunar infarcts were seen in the right lentiform nucleus and thalamus and in the superficial white matter. On diffusion imaging, a hyperintense signal area in the right corona radiata was noted, probably the cause of the recent left hemiparesis (Fig. 1).
Electron microscopy (EM) of a full-thickness skin biopsy revealed granular osmiophilic material (GOM) embedded within the basement membranes of several arterioles, indenting the cell membranes of the vascular smooth-muscle cells, and fragmentation of the vascular smooth-muscle cells and thickening of the basal membranes (Fig. 2).
The visual and auditory evoked potentials and an EEG were normal. Nerve conduction studies of the lower limbs showed no evidence of a polyneuropathy.
Case 2
A 45-year-old white man complained of episodic paraesthesiae of his right hand and speech impairment, followed by severe headache, occurring since the age of 27 years. A neurologist saw him in 2001. The patient had a right-sided hemiparesis and mild asthma, but no stroke risk factors. Two close family members had had strokes, and at least 8 family members had a positive history of migraine (Fig. 3).
At the time of the stroke, general examination and blood pressure were normal, and a right hemiplegia and right hemisensory deficit with slurred speech were found. The patient was seen at Pretoria Academic Hospital 2 years after this incident, with normal cognition, residual weakness on the right side, and bilateral upper motor neuron signs, more marked on the right side. He had a raised total cholesterol level of 7.5 mmol/l.
An MRI scan of the brain showed widespread white matter lesions with moderate involvement of the anterior temporal lobes and extensive lesions in the external capsule. There was hyperintensity of the posterior left lentiform nucleus/posterior limb of the internal capsule and a small lacuna at the cortical-subcortical junction in the left hemisphere.
Electron microscopy showed an abundance of osmophilic granules; the visual, auditory and somatosensory evoked potentials were normal, as was the EEG.
Case 3
A 37-year-old white man presented with migraine, which had started during childhood and worsened after a head injury. The head injury had resulted in loss of consciousness for 5 hours and anterograde amnesia for 2 days. The migraines commenced with a visual aura followed by severe unilateral headache; he experienced an unusually severe attack in 2002, with clouding of consciousness and amnesia lasting 3 days, followed by intermittent left-sided paraesthesiae and visual disturbances in the left field of vision. Seven members of his family had suffered strokes, and at least 5 others complained of migraine (Fig. 4). His blood pressure and general and neurological examinations were normal, as was cognition.
Laboratory tests showed a normal cholesterol level of 4.7 mmol/l, but high-density lipoprotein was slightly decreased at 0.7 mmol/l and low-density lipoprotein was increased (35 mmol/l). No Doppler studies were done.
An MRI scan of the brain showed widespread white matter involvement with prominent abnormalities in the external capsules and to a lesser extent in the anterior temporal lobes.
An MRI scan of the patient's father, who had had a similar history and had died at the age of 58, also showed marked white matter lesions (Figs 5 and 6).
Electron microscopy of a full-thickness skin biopsy showed scattered osmiophilic granules in the basement membranes of several vascular smooth-muscle cells.
The visual, auditory and somatosensory evoked potentials, and the EEG were within normal limits.
Case 4
A 46-year-old white man complained of episodic visual auras consisting of fortification spectra and hemianopia that had started in early adulthood. Headache was initially not a prominent feature. During the last decade, he had experienced hypo- and dysaesthesiae of half of his face and ipsilateral hand together with a visual aura, followed by severe headache. Symptoms cleared over 2 days and recurred approximately monthly. In 2002, he experienced a sudden monoplegia of the right arm which was not accompanied by the other symptoms, which also cleared up gradually.
His medical history included hypertension, which was controlled on perindopril. He had never smoked. One family member had had a stroke, but the patient could not supply much information on relatives. His blood pressure and cognition were normal; mild weakness was present in the right hand, and reflexes were brisk bilaterally. Pronator teres tone was increased on the right, and he had a mild sensory loss over the right half of the face and right arm. He had an elevated total cholesterol level (6.6 mmol/l) and cardiolipin IgM antibodies were borderline raised (22.4 units). Echocardiography and Doppler of the carotids were normal.
MRI scanning showed extensive diffuse white matter lesions, with involvement of the anterior temporal poles and marked involvement of the external capsule, and a large lacuna in the pons surrounded by hyperintensities. A gradient-echo MRI scan showed two microbleeds, one subcortically and one in the lentiform nucleus (Fig. 7).
Electron microscopy of the skin biopsy showed proliferation of vascular smooth-muscle cells, crenation of the internal elastic lamina and fragmentation of elastic fibres. The basement membrane was irregular and osmiophilic granules were observed.
Neurophysiological examination showed normal visual, auditory and somatosensory evoked potentials, while the EEG revealed a single focal burst of sharp transients left mid-temporally; the alpha rhythm showed lower voltage on the left side.
Case 5
A 67-year-old white woman presented with memory problems and behavioural disturbances. The short-term memory loss had commenced 3 years previously; the behavioural disturbances were more recent, involving paranoid delusions, inappropriate behaviour and an obsession with sweets and diet pills. Episodes of confusion and a gait disturbance involving stiffness of the right leg had been noticed. Previously, the patient had suffered from migraine and had been treated for depression. She did not smoke. At least 2 other family members had suffered from strokes; one had been diagnosed with dementia. The patient's daughter suffered from migraine.
Blood pressure and general examination were normal; cognition was impaired, with a Mayo Mini-mental Score of 28/38. Primitive reflexes (snout reflex, palmomental reflex) were present. On the right side, there was mild weakness of the hand and toe extension, brisker reflexes and mild spasticity. Both plantar responses were extensor and Hoffmann reflexes were present on both sides. Both hands were clumsy and the gait was broad-based with a tendency to invert the right foot.
Renal, liver and thyroid functions, full blood count, glucose and vitamin B12 were normal. The antinuclear factor was 1:40, and the rheumatoid factor was negative. Cerebrospinal fluid examination showed only a mild increase in protein (578 mg/l). An MRI scan showed widespread white matter lesions, particularly prominent in the anterior temporal regions and external capsule. Multiple small linear lacunes were seen subcortically. A gradient-echo MRI showed several microbleeds.
Skin biopsy electron microscopy showed typical osmiophilic granules. Neurophysiological investigations showed normal auditory and somatosensory evoked potentials with a normal visual evoked potential on the right and borderline abnormality on the left (prolonged latencies). The EEG was abnormal, with episodes of 2 - 3 Hz delta in the frontal regions.
CADASIL is an autosomal dominant widespread arteriopathy, which may present with migraine, ischaemic central nervous system lesions (transient ischaemic attacks/strokes), subcortical dementia, and mood disorders.
Our patients had a positive family history of strokes in first-degree relatives, except for one who was unable to provide family details. This is in keeping with an autosomal dominant form of inheritance. Migraine with aura was present in 3 patients in whom it was also the first symptom of the disorder; complicated migraine occurred in 1 patient (case 2); case 3 reported a severe migraine, which was followed by clouding of consciousness and amnesia an episode difficult to distinguish from an ischaemic event. Migraine started before the age of 30 years in all patients, in keeping with other reports.3-5 The mechanisms causing migraine in CADASIL are unclear functional alterations of small cerebral arteries may be involved.
Ischaemic events occurred in all our patients, with the first stroke seen at a mean age of 50 years (37 - 66 years). They recovered well after the ischaemic incident; all but one were fully functional after a few months. Traditional vascular risk factors were present in 3 patients, with 2 showing hypercholesterolaemia and 1 hypertension.
The MRI scans showed involvement of the anterior temporal lobes and external capsule in all patients, as typically stated in other reports.6,7 Microbleeds, seen in at least 2 of our patients, were recently also described in patients with CADASIL, occurring in up to 50% of cases.8 Cognitive changes were seen in about 60% of symptomatic individuals, including episodic memory deficits, attention problems, and executive and visuospatial functions and psychomotor slowing.4,5 One would expect about two-thirds of cases, by the age of 65 years, to have evidence of dementia; only 1 of our patients (67 years old) experienced problems with cognition, probably as the others were relatively young.
Mood disorders occur in about 30% of patients with CADASIL.4,5 One of our patients had a previous diagnosis of dysthymia, progressing to behavioural disturbances and dementia within a short timespan.
Few neurophysiological studies on patients with CADASIL have been reported. Sensory neuropathy was found in 7 out of 11 patients who had signs of peripheral nerve involvement.9 Chabriat et al. reported normal nerve conduction studies on 5 of their patients.4 Our patient who had nerve conduction studies was normal. No reports on somatosensory and auditory evoked potentials studies in patients with CADASIL were found. Parisi et al. reported visual function impairment studies in some patients.10 All our patients had normal results for visual, auditory and somatosensory evoked potentials (one showed slight prolongation of latency of the visual evoked potential (VEP)), contrasting with other conditions where CNS white matter disease is prominent. Electroencephalographic studies have also not been reported widely, although up to 10% of CADASIL patients may develop epileptic seizures. Two of our patients had abnormal EEGs: in one, sharp waves in the temporal region raised the possibility of an ictal phenomenon although the patient was asymptomatic, and the patient with dementia showed frontal delta activity on her EEG.
Skin biopsies on electron microscopy in patients with CADASIL show a specificity of close to 100% and a sensitivity of 45 - 96%.11-13 All our patients had an abundance of osmiophilic granules on electron microscopy of their skin biopsies, which confirmed our diagnosis of CADASIL.
Genetic studies, which are not yet available in South Africa, could not be carried out owing to the logistics of tissue transport and costs.
CADASIL occurs in white South Africans, which is not unexpected as many ancestors originate from the countries where CADASIL was first described (e.g. France). A family history must be taken in younger-onset stroke, migraine and dementia patients to correctly identify familial stroke syndromes such as CADASIL and CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leucoencephalopathy, or Maede syndrome). All our clinically suspected cases showed positive electron microscopy results, and MRI was useful in making the preliminary diagnosis. The observation that the evoked potentials studies were normal is notable and may be of value in differentiating CADASIL from other CNS demyelinating diseases.
Professor L Dreyer of the Anatomical Pathology Department, University of Pretoria, and Professor P R Bartel of the Neurophysiology Unit are thanked for their assistance.
1. Sourander P, Walinder J. Hereditary multi-infarct dementia. Morphological and clinical studies of a new disease. Acta Neuropathol (Beli) 1977; 39(3): 247-254. [ Links ]
2. Tournier-Lasserve E, Joutel A, Melki J, et al. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy maps to chromosome Igq 19. Nat Genet 1993; 3(3): 256-259. [ Links ]
3. Desmond DW, Moroney JT, Lynch T, Chan S, Chin SS, Mohr JP. The natural history of CADASIL: a pooled analysis of previously published cases. Stroke 1999; 30(6): 1230-1233. [ Links ]
4. Chabriat H, Vahedi K, Iba-Zizen MT, et al. Clinical spectrum of CADASIL: a study of 7 families. Lancet 1995; 346(8980): 934-939. [ Links ]
5. Dichgans M, Mayer M, Uttner I, et al. The phenotypic spectrum of CADASIL: clinical findings in 102 cases. Ann Neurol 1998: 44(5): 731-739. [ Links ]
6. O'Sullivan M, Jarosz JM, Martin RJ, Deasy N, Powell JF, Markus HS. MRI hyperintensities of the temporal lobe and external capsule in patients with CADASIL. Neurology 2000; 56(5): 628-634. [ Links ]
7. Van den Boom R, Lesnik Oberstein SA, Ferrari MD, Haan J, Van Buchem MA. CADASIL: MR imaging findings at different ages 3rd - 6th decades. Radiology 2003; 229(3): 683-690. [ Links ]
8. Dichgans M, Hoffmannspotter M, Herzog J, Peters N, Bergmann M, Yousry TA. Cerebral microbleeds in CADASIL: a gradient echo MRI and autopsy study. Stroke 2002; 33(1): 67-71. [ Links ]
9. Sicurelli F, Dotti MT, Destetano N, et al. Peripheral neuropathy in CADASIL. J Neurol 2005; 252(10): 1206-1209. [ Links ]
10. Parisi V, Pierelli F, Fattapposta F, et al. Early visual function impairment in CADASIL. Neurology 2003; 60(12): 2008-2010. [ Links ]
11. Markus HS, Martin RJ, Simpson MA, et al. Diagnostic strategies in CADASIL. Neurology 2002; 59(8): 1134-1138. [ Links ]
12. Joutel A, Favrole P, Labauge P, et al. Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis. Lancet 2001; 358(9298): 2049-2051. [ Links ]
13. Lesnik Oberstein SA, Van Duinen SG, Van den Boom R, et al. Evaluation of diagnostic NOTCH3 immunostaining in CADASIL. Acta Neuropathol (Berl) 2003; 106(2): 107-111. [ Links ]
Accepted 5 January 2009.
* Corresponding author: Clara-Maria Schutte (firstname.lastname@example.com)


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With the January 31 tax deadline fast approaching, we look at five ways that people can cut this year's tax bill.
Claim back your National Trust membership
Many higher-rate taxpayers fail to reclaim a tax rebate after giving money to charity. If you have signed a Gift Aid declaration, this effectively boosts the value of your donation by enabling the charity concerned to reclaim basic-rate tax (at 20pc) on this money. What is less widely publicised is that higher-rate taxpayers can reclaim the rest of the tax they have paid on their donation by including details in their self-assessment tax return. Often it is those who just make occasional donations to charity who overlook this fact. Also, many may not realise that buying annual membership of the National Trust or English Heritage counts as a charitable donation, as do entrance fees to most zoos.
Claim back your heating bills
If you work from home on a freelance or self-employed basis – even part-time – you can offset a portion of your utility bills against your tax bill. This doesn't just include heating and lighting bills but telephone and broadband costs too. How much you can claim depends on how much of the home running costs are used for business purposes. This doesn't apply to those who are employed, but if they are working from home they could ask their employer to contribute to such costs.
Rebate on work clothes
This doesn't apply to all workers, only those who are required to wear a uniform to work. However, the definition of uniform is suitably broad, and will also include shop assistants, say, who are required to wear branded T-shirts. If your employer requires you to wear such clothing, and you have to buy, clean, repair and replace it, you can claim tax relief on these costs. For most this is £60 - but some occupations (in the building trade, for example) have a higher allowance of £140. This means a higher-rate taxpayer would be able to claim £56. Remember, it's possible to backdate claims for up to five years (including the current tax year), potentially giving a tax break in excess of £250.
Reclaim subscription costs
Those subscribing to a trade journal can offset costs as a legitimate business expense. This can include iPad or Kindle subscriptions, or even a newspaper if you can justify it as a necessary business expense. However, while the self-employed only have to prove this purchase is "wholly and exclusively" for their work (i.e. not just for fun), those who are employed also have to prove it is a necessary purchase in order for them to carry out their job.
Travel expenses
If you are self-employed you can't claim for the commute between your home and place of work. But lots of self-employed people work from home so can claim for journeys to visit customers, clients or suppliers. Keep records meticulously, though. In addition, you may also be able to offset items such as car breakdown cover against this bill.

subset: commoncrawl


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0 Members and 1 Lonely Barbarian are spying on this topic.
Muldoon makes a close inspection of what everyone is wearing, assessing whether or not it will be appropriate for a 24-48 hour period of exposure in Alaska this time of year.
"A Seiberton. I'll be d**ned, another useful (and here Brian gives a pointed look at Blue's horns) member of our group," Brian said. "So, Jacobim, what sort of weapons are we talking here? Like, personal weapons on the scale of assault rifles, or the big boys that make large, pretty explosions? Did the PMC go down the path of the old, what do ya call 'em, Nazis! Did they experiment with Zero-Point Energy?"Weapons! Thought Brian to himself. If he could get his hands on such a thing, it could revolutionize the criminal world. Brian could make some serious money. But no- from ol' Jacobim's little "pep talk," they were the "heroes." And as such, Brian couldn't be a "villain." Brian smiled to himself. Let's see how things go. And get my hands on those plans. Just in case. For bribe material (if the PRC military got their hands on some of Brian's favorites among the group- naturally taking out the gene-whore mutant from Brian's favorite list), and of course, for late-night reading material.
"where is the target ground located? Do we have preferred mode of approach? What is our preferred timeline?"
"I have a small boat, the use of which for this mission can easily be added to my expense listings. It would not be able to carry a back a great deal of cargo, and all four of us. Do we have a map of the area?"Also Muldoon opens his PAN up again and checks the weather forecast for the next week.
"We will also need to better prepare each you for your extended stay in sub-zero environment. I can make the necessary purchases with regard to supplies and cold weather gear immediately. Do any of you have dietary restrictions and are we expecting any additional pack...party members. If so what are their physical specifications?"Muldoon gestures at the blue bag on the table."Also there are biomonitors in the blue bag on the table. They will monitor your vitals and produce a particulate that I will be track and respond to. If your vitals signs stop or fluctuate significantly I will be able to smell it. It will also help me track you if you get lost. Do not worry about the EM signature they produce it is no greater than if you were to rub your feet vigorously on a carpet. With your permission, I would like to begin acquiring the afore mentioned goods and I have charted a course towards the target range." *forwards the course this to every* "It will keep us close to the shore, the action of the waves should lessen any disturbance our boat engine may make to the environment." Muldoon spreads his wings slightly and turns on his heat sinks. It is warm in here.
Page created in 4.235 seconds with 29 queries.


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Celeste standalone
Control point generators are not very good at distinguishing between static objects, such as buildings, and objects that change quickly such as waves, foliage, clouds and people. This causes alignment problems, especially with clouds that can easily move several pixels between shots.
Celeste is a new tool in hugin that has been trained using w:Support_vector_machine techniques to identify clouds in photos and remove control points from these areas. This functionality is available in the Hugin Images tab and described in the Using Celeste with hugin tutorial.
celeste_standalone is a command-line tool with all the same functionality as Celeste in hugin. It has many options, but at its simplest can be used to just 'clean' an existing project file:
celeste_standalone -i project.pto -o project.pto


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QNotes is the LGBT arts, entertainment and news publication based in Charlotte, N.C.. Check out QNotes at goqnotes.com.
We Need to Talk About HIV and Mental Health
Rarely - if ever - are stories about the intersection of mental health issues with HIV status heard. Individuals living with HIV have a far greater likelihood of experiencing mental health problems than the general population.
Health Director Apologies for Saying HIV Rates High Because Charlotte's A 'Party Town'
Mecklenburg County Health Director Gibbie Harris has apologized for putting part of the blame for Charlotte's high HIV rate on it being a "party town."
Remembering the Transgender People Killed in 2017
Last year set a grim record for the highest number of known transgender people murdered in the U.S. This year is on track to match, or even top, it.
Joney Harper: Advocate, Biker and An Intersex Person
Joney Harper's intersex self-discovery was born in North Carolina. And the road to finding that out was long and arduous as she traversed the landscape to becoming the person she was meant to be.
The A-B-Cs of the Ts
To be an ally to the T in LGBTQ, all queer, cisgender or straight allied individuals need to be aware of the ever-evolving lexicon used to define gender identity and expression.
Women's health risks go beyond breast cancer
The battle against breast cancer is one example of how far a movement can go to address a deadly serious women's issue. Yet, other risks to women's health are not as publicized or as known to the general population.
Travis Wall Brings Shaping Sound Tour to Charlotte
The arts have always been a sort of haven for LGBTQ people. Creation is undoubtedly a form of expression, and that is exactly why Travis Wall of "So You Think You Can Dance" dedicated his life to performance from an early age.
Charlotte Heads to the Polls to Pick Its Next Mayor
Charlotte has already begun early voting in a race to select the city's seventh mayor in eight years.
Cooper Signs Order Extending LGBTQ Protections, Says Trans Bathroom Rights are Protected
Gov. Roy Cooper signed an executive order on Oct. 18 extending protections to members of the LGBTQ community who work for the state, receive state services or work for a company that contracts with the state.
St. Louis Conference Honors 'LGBTQIA Saints and Prophets'
"Rolling the Stone Away: Generations of Love and Justice" brings together pro-LGBTQ Christian leaders from Catholic, Lutheran, Methodist, Metropolitan Community Churches and United Church of Christ communities.


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of degrees
& programs
Concentration: Costume Construction
Fall: June 15
Applications are processed on a semi-rolling basis throughout the spring.
Number Required: 3
From Whom: Letters of recommendation should be obtained from college/University Professors, Professionals in the field.
No standardized tests are required.
The student's portfolio should contain examples of work, ranging from projects and classroom exercises to completed projects. The portfolio should include research materials, rough sketches, and examples of works in progress.
The interview is scheduled with members of the design faculty or at the U/TRA auditions.
A resume is required.
Special Circumstances
Main Campus
Students are required to complete the degree program through classes offered before and after 4:30 p.m.
Number of Didactic Credits Required Beyond the Baccalaureate: 60
Required Courses:
Theater 407, 408, 440, 463, 464, 468 ,467, 472, 473, 994 plus several course specific to the student's production emphasis as decided by the student and approved by the design faculty.
Students must earn credits in the following areas: thirty-three credits in required courses (above), fifteen credits in costume design, six credits (one per semester) for production seminar. The remaining credits are determined by consultation and approval of the design faculty, with the student developing his or her own program of study based on individual interests, academic needs and talent.
Internship: No internship is required.
Language Examination: No language examination is required.
All design and technical students must actively be a part of the Theater Department's mainstage season. The production work is an extension of what is presented in the classroom and gives practical experience.
All design students must particaplate in portfolio review and faculty evaluation at the end of each semester.
The Master's Thesis is typically a realized and produced production, executed by the Theater Department as part of their mainstage season. The underlying premise is to create and produce a professional design within a professional production. Along with gathering all research, creating all designs, drafts, renderings, models, and samples for the design, the student is required to write a document defending the design and explaining the process.
Students meet with their Thesis advisors throughout the period of designing and executing the show as well as meeting with advisors during the writing of the Thesis.
The Thesis advisor, in consultation with the Design Faculty and the Artistic Staff of the production, discusses the progress and results of the Thesis.
Tomlinson Theater
1301 West Norris Street
Philadelphia, PA 19122
Darlene Plunkett
Program Coordinator:
Martin Dallago
Assistant Professor
Head of Design Program in Theater
Graduate Chairperson:
The Design Program for Theater is a professional training curriculum where M.F.A. designers and technicians collaborate with professional faculty, staff and guest artists to stage exciting, contemporary theater for diverse audiences. We are looking for aspiring designers who will pursue the intent of the play wherever it leads them, into any period or style, into any emotion or state of mind, and whose knowledge and skills are so various that they bring a rich theatricality to the worlds they create. The Design Program for Theater combines intensive classroom work with full-scale productions to create well rounded designers and technicians. Our graduates find work in many aspects of theater, including regional theater, educational theater, and the entertainment industry.
Time Limit for Degree Completion: 3 years
Main Campus
Students are required to complete the degree program through classes offered before and after 4:30 p.m.
1301 West Norris Street
Philadelphia, PA 19122
The Temple University Theater Department's M.F.A. Program is nationally ranked 23rd in the 1997 for Graduate Theater Programs by U.S. News & World Report.
The Theater Department is accredited by the National Association of Schools of Theater (NAST).
Each student, in consultation with the faculty,
develops his or her own program of study based
on individual interests and talent. Students
may specialize in one or more of the following
areas: Scene Design, Costume Design, Costume
Construction, & Lighting Design. Full-time
faculty members are available for mentoring.
The program is primarily focused on training our students for careers in the theater industry. Graduates of the Design Program find employment in regional theater, higher education, and the entertainment industries.
The Theater Department of Temple University has informal affiliations with the Philadelphia Theater Company, Freedom Theater, and The Lighting Practice. Students, with special permission from their advisors, have the opportunity to intern at these and other professional theaters and production companies in the greater Philadelphia area. The Theater Department is a Member of ATHE, NAST, U/RTA and USITT.
Design students are encouraged to explore other fields of study, such as art history, cinematography and photography, as their fields of study allow.
Not applicable.
Non-matriculated students are required to get written approval by the instructors for each class they wish to take, along with all university approvals.
Teaching Assistant (TA) and / or Academic Internships (AI): Practical production work within their area of training. Lab, studio and classroom teahing opportunities available. Assistantships carry a stipend and full-tuition scholarship.
Other Financial Opportunities


text: This cotton poly blend hat has the look of fitted, with the flexibility of a range of hat sizes. The comfort of the Flexfit features a comfort stretch sweatband. Eight rows of stitching on the Pre-curved PE visor. Available in sizes small/medium (7 - 7 3/8) and medium/large (7 1/4 - 7 3/4). Gray front with navy under the bill and back of the hat. This embroidered hat has a 3D effect with the word "Academy".


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by Sue Ann Rybak
Facing a $304 million budget deficit for the 2014 fiscal year, the School District of Philadelphia announced that without further funding from the state or city it will be forced to cut guidance counselors, librarian services, music education, sports, after-school programming and office administration.
Despite the School Reform Commission's decision to close 23 schools in September, Dr. William R. Hite, superintendent, said that "without additional support from the city and state, we will not be able to support district operations which will have a direct impact on meeting the basic needs of our students."
The Local asked residents to voice their opinions about the district's budget and its request for additional funding from the city and the state. The overwhelming response from community members was that regardless of who is to blame for the district's current financial plight, every child in Pennsylvania has the right to a quality education in a safe environment that includes access to music and art, libraries, counselors, and support systems that help every child reach his or her full potential.
Rebecca Dhondt, a Mt. Airy resident and J.S. Jenks Home and School Association board member, said the IDEA (Individuals with Disabilities Education Act) is federal law that states that every child is entitled to a free and appropriate public education.
"Is there anyone that can argue this budget would create an appropriate educational environment for the children," Dhondt said. "I am mystified there is not more outrage about this issue. No money for counselors, paper or textbooks? No lunchtime aides, which means inadequate supervision? How can this even be legal? I hear all the people say the system is broken, and we need to fix it, but not on the backs of our children."
Susan Whiteman Nordlof, of Mt. Airy, said she was "shocked but not surprised" at the district's proposed budget cuts.
"Do I think it will become a reality," Nordlof said. "It's hard to believe it can. It makes for a situation that sounds literally unable to function at all on a daily basis, let alone deliver any kind of basic education.
"On the other hand, I no way think it's a total bluff," said Nordlof, whose daughter attends Masterman High School.
She said that people who don't have children in district schools may "just tune this [the district's cuts] out.
"But a city that is ready to give up on even the attempt to provide a decent, basic, well-staffed environment for its children's education is a city that is saying it's ready to give up on a whole generation of its future, whether to poverty and neglect or to flight," said Nordlof, a nurse practitioner at Mt. Airy Pediatrics. "Whether or not you're a public school parent or a parent at all, if you're a Philadelphia taxpayer, you ought to be very worried about that."
Germantown resident Catherine Collins, who has two children at C.W. Henry School, said the district's current financial nightmare didn't happen overnight.
"The unwillingness of the Governor, the Pennsylvania legislature, and the leaders of Philadelphia to take responsibility for a situation that we all find ourselves in is shameful," said Collins, a reference librarian at St. Joseph's University. "I fear for what will become of our children and this city if our leaders sit by and allow this to happen. And so, I ask them: Do you want Philadelphia to be known as the next Austin or another Detroit"?
Anuj Gupta, a Mt. Airy resident and executive director of Mt. Airy USA, said the proposed budget would effectively dismantle "one of the nation's largest public school districts."
"It will tear out the very fabric of our neighborhoods,"Gupta said. "This simply cannot be allowed to happen."
Ken Weinstein, owner of the Trolley Car Diner in Mt. Airy, agreed with Gupta. He called the proposed budget cuts an attack on everything that is good in the school district.
Weinstein, who founded the Mt. Airy/Chestnut Hill Teacher's Fund five years ago, said the Teacher's Fund donates $10,000 a year to local public school teachers for educational projects and supplies.
"There is just not enough funding available to make up for this latest round of gut-wrenching cuts," Weinstein said.
Chestnut Hill resident Bob Previdi agreed and called the district financial dilemma "a very serious situation."
"People have to come together, and we all have to chip in and deal with the crisis now," Previdi said. "For too long we have been kicking the can down the road."
Previdi said he hoped the neighborhood rallies around Jenks.
"Both of our children got a great education there and have been able to attend Masterman, the best school in the state."
Noreen Spota, of Chestnut Hill, said her daughter also received a great education at J.S. Jenks.
"It was important to my husband and I that she attend schools with cultural diversity," Spota said. "Also, like so many other parents in the city, there was no way that we could afford elementary and high school tuition totaling over $300,000 and save for her college education at the same time. Every child in this country, regardless of their economic status, has the right to a high quality education."
Chestnut Hill resident Adam Eyring, whose children attend Jenks, said the quality of the education at J.S. Jenks is "in danger of severely eroding, putting parents in a quandary about the feasibility of living in Chestnut Hill and surrounding neighborhoods due to possibly reduced school options."
Brett Hart, of Mt. Airy, commented on the disparity in education funding between low income and middle or high income neighborhoods.
"It's 'tough luck for you if you're in the former," said Hart, executive director of the Philadelphia Wooden Boat Factory. "We don't fund our highways like that, so why is it accepted practice for education?
"There is a voice out there that wants us to believe that it's not about money – that it's bad teachers, or unions, administration, curriculum, families, values – it's an exhausting list. And while it is complicated, I can say – from the perspective of a youth-development nonprofit director – that without the cash capital, surely nothing good can begin."
The Rev. Linda Noonan, co-pastor of Chestnut Hill United Church, also commented on the disparities in the Philadelphia area, calling them "shocking, unjust and unethical."
"All our children deserve to develop mentally, emotionally and physically in safe and enriched schools," she said.
Tamara Anderson, of Germantown, said research continues to prove how an education rich in art increases critical thinking and evaluation.
"We claim to be teaching our children 21st century skills, yet creativity is the skill being asked for," said Anderson, whose daughter attends Lingelbach Elementary School. "STEM [Science, Technology, Engineering and Math] education is very vital."
Anderson, a teacher, actor and writer added that the district needs to be audited to make sure it is spending money on necessary items.
As a teacher in the Philadelphia school district, Anderson said she had "seen closets and closets of unused books and supplies."
Susan Gobreski, executive director of the Education Voters Institute in Pennsylvania, said good quality public schools should be a public priority.
"The reality is that urban renewal and quality education are intertwined," Gobreski said. "When school quality is diminished, it hurts the communities' prosperity and vibrancy."
She added that citizens need to pressure legislatures "to stop paying this issue lip service or jumping on reform bandwagons."
"We need them to pursue proven initiatives like keeping arts and music programs, community schools, which integrate community programs into the school.
Chestnut Hill resident Julia Reeb, whose daughter used to attend J.S. Jenks, said, "The entire district is a mess."
"Quite honestly, as a current homeschooling family, I have no intention of jumping back into the mess that is the School District of Philadelphia any time soon."
Despite facing crippling budget cuts, J.S. Jenks' principal Mary Lynskey said the school was determined to maintain its diverse enrichment programs.
During a recent school production of "The Sound of Music," Lynskey told an audience of more than a hundred parents, students and community members that "nothing we started here is going to be lost."
"We don't know how we're gonna do it," Lynskey said. "We don't know where we are gonna find the funds, but we will not allow our children to miss out on our JAM [Jenks Art and Music] or FLEX [Foreign Language Experience] programs."
She said the school has petitioned the school district to change it name from the John Story Jenks School to the John Story Jenks School for the Arts and Sciences.
The School Reform Commission is scheduled to vote on a final budget on May 30.


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The autoclave could be a device accustomed sterilize (deep clean) medical instruments. It didn't begin out as a medical instrument. In fact, the autoclave was originally fabricated and promoted as a technique for getting ready food by French medical practitioner Denis Papin. Papin known as his invention a "steam autoclave." He represented his "New Digester" in a 1681 pamphlet, emphasizing the advantages of using the device to method food for easier digestion (the method by that food is de-escalated for absorption into, or elimination out of the body).
The autoclave is a pressure cooker. A autoclave could be a instrumentation with associate airtight lid that traps steam from boiling water. The steam will increase the pressure within the cookware, that raises the water's boiling purpose. the upper temperature kills bacterium a lot of quicker than at lower temperatures. The autoclave includes a security valve to forestall explosion if the steam pressure gets too high.
The scientific basis for sterilization remained a mystery till the work of French chemist Louis Pasteur (1822-1895) became wide glorious and accepted. Pasteur's investigations within the decennium dealt originally with food, one thing the autoclave was originally designed to method. In his rummage around for an answer to the spoilage of wine and brewage, biologist found that bacterium was killed at a hundred and twenty degrees Gabriel Daniel Fahrenheit. Applying this to his scientific ways, biologist unreal the sterile technique of boiling or heating instruments to kill microorganisms. it absolutely was Pasteur's efforts that led to the ultimate use of the autoclave as a customary medical tool.


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1/4 yard each of red print Nos. 1 and 2 (blocks)
1/2 yard each of black print and cream tone-on-tone (blocks)
1/2 yard each of red-and-black floral and red-and-cream floral (blocks)
1/2 yard solid black (binding)
2-3/4 yards backing fabric
49x51" batting
Finished quilt: 40-1/2x42-1/2"
Finished block: 8x14"
Quantities are for 44/45"-wide, 100% cotton fabrics.
Measurements include 1/4" seam allowances. Sew with right sides together unless otherwise stated.


text: The Argus® II Retinal Prosthesis System The Argus II Retinal Prosthesis System ("Argus II") is the world's first approved device intended to restore some functional vision for people suffering from blindness. Argus II is approved for use in the United States and the European Economic Area. HUMANITARIAN DEVICE: Authorized by Federal (U.S.) law to provide electrical stimulation of the retina to induce visual perception in blind patients with severe to profound retinitis pigmentosa and bare light or no light perception in both eyes. The effectiveness of this device for this use has not been demonstrated.


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A small but rugged, high performance breaker or demolition hammer. Great for working on walls and floors. A hire includes 1 point and 1 chisel; a spade and vinyl tile lifter are optional extras.
here.Read our terms and conditions
Perfect for our needs; fast service & excellent trailer provided.
I hire from Vermont Hire all the time and am forever singing their praises. Over the years I tried Kennards Hire and Hire-It but the level of service and state of the equipment from each of these places pales into insignificance compared with Vermont Hire's. The staff are outstanding, very friendly, very patient, very knowledgeable and are very keen to ensure you are hiring the right piece of equipment for the job you need. The equipment works first time, every time, they are contactable if you have problems when using it and they show you how it works, what to do and what not to do before they set you free with it. They are now my one and only hire shop and I often ask them for their advice before I even start one of my many DIY projects.
Equipment is in excellent condition, prices are great and service was friendly and very helpful. Highly recommend them.
I happened to find Vermont Hire and hired a generator from them. Friendly staff and good products and price. Definitely recommend!
I had a very positive experience hiring a line trimmer. They answered all the questions I had about the job, the deposit process is simple and painless, and they supplied me with extra fuel and spare lines for the trimmer with no hidden costs. Great value for money and good customer service.
Great pricing, even better customer service.
We hired a scissor lift for a painting job in Warrandyte. The machine was in great condition, delivery was punctual and the delivery driver was very polite and gave us a good induction. It saved us a lot of time and did the job easily, and at a fair price of course! It was a very good hiring experience, look forward to hiring from Vermont Hire again - highly recommend!
Hired a chainsaw. It was in great condition and did my task easily. Vermont Hire had the saw available on short notice. Really good service and would recommend without hesitation. Excellent!
Vermont Hire is a fantastic business. The hiring process is always straight forward, hassle free and reliable! As a local Vermont based business we often hire their pressure cleaners if we need an extra one for the day. If you're looking to hire from people who know what they're doing, these are your guys! Highly recommend!
We have been dealing with the team at Vermont Hire for several years. Their service, pricing, available equipment and, most importantly for us, equipment reliability is great. Well done!


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Acoustiguide has extensive experience matching celebrity voices to audio programs. Often, a celebrity has a special connection to an institution or exhibition subject, allowing for a modest honorarium. For commercial projects, there is a more substantial licensing fee for celebrity narration. We work with the celebrity to arrange recording times and locations. Recently, we have recorded audio tours with Jeremy Irons, Walter Cronkite and Tom Brokaw.
Yes, many of our clients offer programming in various languages. Acoustiguide provides complete translation services and narration by native speakers. We have produced programming in 20 languages, including English, Spanish, Italian, French, German, Portuguese, Japanese, Mandarin, Cantonese and Korean.
Yes, we encourage your experts to use the audio program to connect with visitors. Consider including your president, director or curators as narrators.
Yes, call us to discuss any project that involves an audio and/or multimedia tour program.
Acoustiguide's creative team writes the majority of our clients' scripts. Our writers are experienced in this medium, and our creative team works closely with the client's staff from concept through final editing. In some instances, the client provides a script and relies on us for editing, production and transfer to digital audio format.
Acoustiguide works with hundreds of professional voice talents. We always provide several audio samples of voices for you to choose from.
We use sound thoughtfully to enhance the visitor's experience without diluting the educational message. Acoustiguide maintains an extensive library of music and sound effects available at nominal cost, and we can compose original music. The use of well-known music requires a licensing fee.
Acoustiguide writers are specially trained in the art of Visual Description, which offers visitors with poor vision an enhanced sense of their physical environment. During the production process, we work with advocacy groups to test our work on site. Acoustiguide's proprietary equipment also has features to serve visually-impaired visitors, including easy-to-use control buttons, telephone-style keypads and raised dots identifying the number five.
All of our digital equipment feature:
Raised dots that indicate the number five on the keypad
Color-coded and shaped control buttons
Compatibility with hearing aid T-switch
Lightweight design with comfortable carrying strap
Telephone-style keypads with backlit buttons


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Petition of the day
The petition of the day is:
Louisiana v. Leonard
Docket: 11-1392
Issue(s): (1) Whether prisoner free exercise claims should continue to be analyzed under the rationality standard set forth in Turner v. Safley, or, as other courts have recently held, under the neutrality standard set forth in in Employment Division v. Smith; and (2) if prisoner free exercise claims are to be analyzed under the rationality standard set forth in Turner, whether that analysis includes the strict scrutiny requirement fostered in pre-Turner jurisprudence.
Certiorari stage documents:
Recommended Citation: Ben Cheng, Petition of the day, SCOTUSblog (Jul. 17, 2012, 11:12 PM), https://www.scotusblog.com/2012/07/petition-of-the-day-314/


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Sore nipples can be so painful that women decide to wean. Although some nipple tenderness in the early days of breastfeeding is rather common, breastfeeding in general should not hurt. Nipple pain and sore nipples indicate that something goes wrong.
In most cases sore nipples are caused by improper positioning and incorrect latch-on or incorrect removal of the baby from the breast. Therefore always turn to your lactation specialist if you experience nipple pain or sore nipples. As soon as the cause for the discomfort is evaluated the problem can be solved.
If the pain is extreme it might be advisable to temporarily interrupt breastfeeding. During such an interruption you must express your milk to avoid engorgement and to keep up your milk production. Your lactation specialist can inform you about breastpumps and hand expression and about alternative feeding methods to feed your baby during this time.
If you want to support the healing process, modified lanolin PureLan can be applied to the nipple. Moist wound healing is considered the treatment of choice. Avoid any ointment that must be wiped of before feeding the baby. This will irritate the skin even more. Breastshells can help protect sore nipples.
In some cases nipple soreness can be caused by thrush. If thrush is suspected contact your doctor to discuss medication for treating both you and your baby.


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The Restore brand offers liquid-armor resurfacers that provide a high-performance, low-maintenance, long-lasting alternative to the endless cycle of repairing and repainting worn surfaces. Its products can be used on wood and composite decks, concrete, docks and more.
Headquarters: Vernon Hills, Illinois Phone: (800) 373-6333 Website: www.rustoleum.com/product-catalog/consumer-brands/restore
This website uses cookies and other tracking technologies (also known as pixels or beacons) to aid your experience (such as viewing videos), as well as "performance cookies" to analyze your use of this website and to assist with marketing efforts. If you click the "Accept All Cookies" button or continue navigating the website, you agree to having those first and third-party cookies set on your device. If you do not wish to accept cookies from this website, you can choose to not allow cookies from this website by updating your browser preferences. For more information on how we use Cookies, please read our Privacy Policy.


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Monday, November 17, 2008
November is here, Christmas is coming - Stocking Stuffers Picture
In preparation for Christmas, and in response to "Smile For the Camera" - a Blog Carnival for genealogy, with a subject of "Stocking Stuffer" - I've found a photograph to submit for this December's Blog Carnival. My "Stocking Stuffer" photo is ME in a Christmas Stocking. It was my first Christmas and my parents hung a big stocking with me as the stuffer. My brother, Richard Hague, is standing next to me (Donna) in front of our fireplace, in Los Angeles, California. He's probably thinking that this was not what he had asked Santa for! The year was 1945. I hope the hook was sturdy, but I guess it was, as I don't remember becoming unstuffed if it gave way. I'm wearing a pink crochet top that my great-grandmother, Edith (Akins) Blanding probably made for me when I was born. Previous editions of "Smile For The Camera" can be found at the "FootnoteMaven's website: http://www.shadesofthedeparted.com/
Posted by Donna Hague Wendt on Monday, November 17, 2008
Labels: Family - Akins
4 comments:
- Judith Richards Shubert said...
Donna, this is the most precious photograph! Perfect for this Carnival. I'm especially fond of your pink crocheted top. I used to crochet for my little ones and this reminds me of those little things.
- Monday, 15 December, 2008
- Bob Kramp said...
Really cute! They would have to use a railroad spike to hang me up on the mantle.
- Monday, 15 December, 2008
- Janet Iles said...
What a great Christmas present. Your brother does have that questioning look. I am sure he was pleased to have you as his little sister.
- Monday, 15 December, 2008
- Taylorstales-Genealogy said...
What a terrific stocking stuffer picture! I think I would frame this one! Merry Christmas!
- Monday, 15 December, 2008
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Learn how MacUpdate Desktop can install apps on MacUpdate with the simple click of the icon. Plus, keep all your apps updated.
Buy now and save 25% on Onde Rulers for Mac with our exclusive coupon code: 1058852D87
Onde Rulers is an accurate virtual screen rulers on Mac, by which you can measure dimensions of objects in Pixels, Inches, Picas, Centimeters and calibrated units. In addition, a built-in protractor can measure angles in angles and radians.
- Quickly and easily measure the length and width of any object in pixels, inches, picas, centimeters, angles, radians and some other units customized
What's New in Onde Rulers
- Fix the bug that caused memory leaks when capturing screen.
Requirements for Onde Rulers
- OS X 10.6 or later


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What is each mathematical step (in detail) that one would take to get from:
$E^2 - p^2c^2 = m^2c^4$
$E = \gamma mc^2$,
where $\gamma$ is the relativistic dilation factor.
This is for an object in motion.
NOTE: in the answer, I would like full explanation. E.g. when explaining how to derive $x$ from $\frac{x+2}{2}=4$, rather than giving an answer of "$\frac{x+2}{2}=4$, $x+2 = 8$, $x = 6$" give one where you describe each step, like "times 2 both sides, -2 both sides" but of course still with the numbers on display. (You'd be surprised at how people would assume not to describe in this detail).


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If you're searching for a permanent way to improve the quality of your smile while avoiding grinding or drilling, veneers may be the answer. Veneers are bonded directly to the surface of malformed, broken or discolored teeth – providing a polished, straight look.
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Enhancing your smile at a great value, composite resin veneers can improve your teeth at a lower cost. In this procedure:
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Crafted to provide a beautiful appearance and comfortable fit, porcelain veneers are an excellent option to improve your smile. The process is quite simple:
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- The veneer is attached with durable bonding cement.
Don't go another day feeling self-conscious about your smile. Call your Cosmetic Dentist Frisco TX today at (214)-436-5122 and acquire the smile you've always wanted!


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Open since the late 1970s, this infamous outlet in the lower arcades of Seattle's Pike Place Market offers thousands upon thousands of historic pop-art prints and advertisements from the 20th century. Primarily ads extracted from North American magazines, their stock for sale also includes reproductions and other unique individual graphic design prints.
This 360 photographer has spent hours and hours cumulatively over multiple visits to this small store with it's famous giant-shoe entry-way constructed in the late 1990s.
The United States is one of the most diverse countries on earth, jam packed full of amazing sights from St. Patrick's cathedral in New York to Mount Hollywood California.The Northeast region is where it all started. Thirteen British colonies fought the American Revolution from here and won their independence in the first successful colonial rebellion in history. Take a look at these rolling hills carpeted with foliage along the Hudson river here, north of New York City.The American south is known for its polite people and slow pace of life. Probably they move slowly because it's so hot. Southerners tend not to trust people from "up north" because they talk too fast. Here's a cemetery in Georgia where you can find graves of soldiers from the Civil War.The West Coast is sort of like another country that exists to make the east coast jealous. California is full of nothing but grizzly old miners digging for gold, a few gangster rappers, and then actors. That is to say, the West Coast functions as the imagination of the US, like a weird little brother who teases everybody then gets famous for making freaky art.The central part of the country is flat farmland all the way over to the Rocky Mountains. Up in the northwest corner you can find creative people in places like Portland and Seattle, along with awesome snowboarding and good beer. Text by Steve Smith.


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Patient Center
October 14, 201910:30 AM
Thank you for choosing Dr. Misra for your medical needs.
If you are unable to find a desired time, please contact the office at 843-695-2700 and the medical office specialist will be happy to accommodate you.
To reschedule an appointment, call us directly at 843-695-2700.
In order to expedite your visit, please bring the following items:
· A list of current medications.
· Insurance card(s) and a Photo ID.
New Patients, Please complete your paperwork before arrival.
You can find your new patient forms at the link below:
New Patients, in order to finalize your registration process, please arrive 30 minutes before your scheduled appointment time.
For questions about insurance and billing, call us directly at 843-695-2700.
Thank you again, and we look forward to seeing you!
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It's hard to believe, but the NBA season is just around the corner. So come with us now as we present five tiny tidbits on each team, just to get you in the mood. Today we continue with the Atlantic Division, so do us a favor and send your tips email@example.com.
• 1. Keep On Truckin' Baby. Trucking magnate Arthur Brown established the franchise was established in 1967 as part of the American Basketball Association, planning to name them the New York Freighters, based on Manhattan's east side. But pressure from the New York Knicks forced their arena, the Armory, to back out three months before opening day. The team was forced to move to Teaneck, New Jersey, and changed its name to the New Jersey Americans.
• 2. Boo-yah! Blame Vince Carter's 2001 playoff exit on Stuart Scott. On the morning of Game 7 of the 2001 Eastern Conference playoffs (Raptors vs Philadelphia 76ers), Carter attended his University of North Carolina graduation, in which Stuart Scott gave a graduation speech. That night, Carter was 6-of-18 from the floor and missed a potential game-winning shot with two seconds remaining.
• 3. Hey Moe! Hey Larry! Nenad Krstic — nickname Curly — was voted third most eligible bachelor by Serbia's version of People magazine.
• 4. Computer Glitch. While a senior at UConn, Marcus Williams was charged with trying to sell four stolen laptop computers taken from dormitory rooms on the university campus. He was suspended for the fall semester and did not play his first game of the season until January 2006.
• 5. Hassan Chop! As a senior at Arizona, Hassan Adams recorded a double double; being charged with both disorderly conduct and a DUI on two seperate occasions. In the latter, he was found to be driving with blood alcohol level of .124 (the Arizona legal limit is .08). He's still pretty good, though.


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SoBe Mixology (Episode 5)
Video Pitch by izzytraub
izzytraub was paid to create this video. Learn how to get paid on Quickframe.
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22 Videos
Vancouver, BC
Food & Drink, Music & Dance, Pop Culture
I'm a filmmaker based out of Vancouver, BC. I've been making films since I was 8 and am curren...View Channel
In this episode we make a Creamy Mango, Avacodo and Lime Smoothie.
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Video Quality
Professional web series style. Ideally 1080P video resolution. Include professional lighting, editing and sound design.
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Biochemical failure after treatment of prostate cancer
Dear OncoLink "Ask The Experts,"
A close friend of ours has been diagnosed with prostate cancer and had brachytherapy about 6 years ago. His PSA levels have been normal between that time and present, but a recent PSA test showed the level increased to 5.5. Bone scans show that there is some cancer present somewhere but cannot be pinpointed. They realize that further seeding cannot be done, and have been told about hormone therapy, which they do not want to pursue. What other treatment options are available to them at this time?
David J. Vaughn, MD, Associate Professor of Medicine Abramson Cancer Center of the University of Pennsylvania, responds:
Biochemical failure after definitive treatment of prostate cancer is a complicated field. The first question is whether the biochemical recurrence is clinically significant or not. For example, some patients may have biochemical failure but be at extremely low risk of developing metastatic disease and can be observed. Others are a high risk of developing metastatic disease and need androgen ablation. Also, one must question whether this is a local recurrence (in the prostate) versus a systemic recurrence (metastasis). A bone scan should be able to localize a bone metastasis from prostate cancer. Thus, in this particular case, one needs more information. For many patients, if treatment is required, androgen ablation therapy is a standard approach.
There are also some experimental therapies being tested at the University of Pennsylvania using photodynamic therapy (PDT) for the treatment of local recurrence of prostate cancer after either external beam radiation therapy or seed implants. For more information on clinical trials, please visit the OncoLink Clinical Trials Matching service.


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The regent universities are asking for the state to provide enough funds so that they don't have to increase tuition next year. In and of itself this is probably a good idea. However, they must do all they can to reduce costs at our universities. The regent universities are in the process of doing just that. They have hired a consulting firm to examine all university business foundations, programs and facilities. Deloitte LLP was recently hired by the board of regents to do this examination. Nothing is off the table, and all ideas and questions are welcome according to a letter written by Sally Mason the president of the University of Iowa. Some of the savings need to be put back into the schools in a form that reduces student's tuition.
UNI will host a forum on April 7th. All three schools also are accepting public suggestions online via websites created for the efficiency initiation. In the months ahead each department and each university will undergo audits and interviews to address what is being done well and what needs to be improved.
This is an opportunity to get involved and express your thoughts on how the regent universities can improve.
We have been working on SF2310, commonly referred to as the "social host bill". Under the bill, a person who is the owner or lessee of, or who otherwise has control over, property that is not a licensed premises, shall not knowingly permit an under legal age person to consume or possess an alcoholic beverage on such property. The bill provides that a person who violates this provision commits a simple misdemeanor for the first offense, punishable as a scheduled violation with a fine of $200, and a simple misdemeanor for a second or subsequent offense, punishable by a $500 fine.
There is a difference with some of the social host ordinances passed by our cities and counties, that change deals with the age at which a person could be charged. For a first offense, a person who is 18, 19, or 20 who consumes alcoholic liquor, wine, or beer in violation of the bill commits a simple misdemeanor punishable as a scheduled violation. For a second offense a person commits a simple misdemeanor punishable by a fine of $500. Currently some of the city and county ordinances are stated as under age 21. However, the 18, 19, and 20 year olds will be amended out of the bill leaving a difference between many of the ordinances and the state law. The fines are also different in the ordinances than in the proposed state law.
I had the opportunity to attend the signing of the corn check off legislation in the governor's office. That legislation passed unanimously in both the House and Senate.
I encourage anyone to contact me with questions, concerns, and new ideas on how we can improve Iowa even though the 2014 session is coming to an end. It is an honor to be your Representative, and I will continue working hard for all of you and for the great state of Iowa.


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At 9 years old, he has a website, a viral YouTube video, and a mock logo that reads "Seal of the Tiny President of the United States."
The Kid President's motto: "Don't be in a Party. Be a Party."
His "Pep Talk" YouTube video (see below) has been taking social media sites by storm for the past week, and the message is simple: "The world needs you to stop being boring…. Boring is easy."
The adorable boy sending smiles around the world is Robby Novak of Henderson, Tenn., who has been posting videos on the SoulPancake YouTube channel since October with the help of his adult brother-in-law, Bradley Montague, the TodayNews website reports. Novak appeared on the "Today" show Wednesday.
SoulPancake, founded by Rainn Wilson of "The Office," encourages people "to explore what it means to be human."
Kid President's take on that includes this comment from his video: "This is life, people. You got air coming through your nose. You got heartbeat. That means it's time to do something!"
The video, in which Robby is dressed in a dark suit and red tie, weaves together humor, music, pithy philosophical comments, cute dance moves, poetry, and gentle reprimands to grownups.
After quoting from Robert Frost's "The Road Not Taken," he says, if there really were two paths, "I want to be on the one that leads to awesome."
The video has had more than 6.4 million hits so far.
Among the people passing it around via Twitter were actor Nick Cannon; Cory Booker, the mayor of Newark, N.J.; and Kaya Henderson, chancellor of the District of Columbia public schools.
The Monitor checked in with a third-grade class at Smithfield Elementary School in North Carolina's Charlotte-Mecklenburg Schools to get their take on the video.
Students in Heather England's class won the "If We Were President" contest by education-servinces company Pearson with a video of a song they wrote, "Vote Me Maybe," inspired by the election season.
The Kid President's video was "great" because it sends the message that "it doesn't matter who you are,… it's what's inside that counts," says Davis, one of the third-graders, in a phone interview.
"It encourages you and motivates you to do the right things," adds his classmate Jada. "God made us for a reason … not just to sit around," she said.
Robby reminds the students of Martin Luther King Jr., because he encourages people to work together, Ms. England says.
Robby's video raises the question of what would happen if Michael Jordan had given up, and that really resonated with her students, she says. "They talked about, 'On a test, what if I had given up? Last time I made a 'B' and I didn't get upset, and now I have an 'A'," she says.
The school shows an inspirational video each morning, and England was surprised this one hadn't been shown schoolwide yet. The videos generate conversations and help students and adults alike stay motivated, she says.
"I wish more adults … had the mindset of kids," England says.
She recently reinstated a practice she and her students did regularly in the month of November – starting the class by writing down what they are grateful for. "I don't know who needs it more, me or the kids," she says.
Robby has been praised by marketing experts for his savvy use of social media. But it doesn't appear he's angling to sell anything but encouragement (he does have one simple T-shirt for sale on his website, which is sponsored by his mom). At the end of the "Pep Talk" video he dedicates it to a young friend who is fighting cancer.
"Who encourages you?" he asks – urging viewers pass the video along to them to let them know.


text: Lionel Messi: ALL 50 GOALS for Argentina 2006-2016! By Rodrigo Gomez - June 27, 2016 1572 Facebook Twitter Google+ Pinterest WhatsApp RELATED ARTICLESMORE FROM AUTHOR VIDEOS VIDEO: Top 10 Euro 2016 Goals! VIDEOS This 11 Month Old Baby Trying to Walk a Bulldog Is The Cutest Thing You Will See All Day VIDEOS Farah Khan can't stand a funny tweet and abuses the person by sending him DM VIDEOS This video of The Great Khali sharing the problem he faces in his daily life and its solution will make you laugh VIDEOS The real reason behind the suicide of builder Suraj Parmar VIDEOS Nobel Laureate Kailash Satyarthi Launches Campaign Against Child Abuse With This Disturbing Video VIDEOS 'I'm 100% NY, but I'm also 100% Bihar'; Tweets The 'Hulk' Star Mark Ruffalo VIDEOS Karan Johar breaks down on 'Jhalak Dikhla Jaa Season 8' VIDEOS Can Bee Sting Be Fatal? Watch This Video of Janice Dickinson !! VIDEOS Nick Clayton Gets Locked In LA Fitness After Its Closing Time dimpy.tv LEAVE A REPLY Cancel reply Please enter your comment! Please enter your name here You have entered an incorrect email address! Please enter your email address here Save my name, email, and website in this browser for the next time I comment. Latest Buzz! 4 things you missed in Avengers End Game trailer LOL / OMG / WTF / FUN Facts December 25, 2018 NASA has recreated famous movie posters in a funny way SOCIAL December 25, 2018 Top 5 loved pictures on Instagram by Indians on 2018 SOCIAL December 20, 2018 5 Unbelievable Health Benefits of Coffee that will surprise you LOL / OMG / WTF / FUN Facts December 13, 2018 5 Fashion Hacks To Look Taller And Leaner LOL / OMG / WTF / FUN Facts December 10, 2018


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Lille travel information
Getting to Lille by air
The nearest international airport to Lille is Lille-Lesquin airport, which has a limited number of European and domestic connections. It is approximately 10km from the stadium.
For more information on airport assistance, visit: www.lille.aeroport.fr/prepare-for-your-journey/special-assistance/
Travel assistance for disabled passengers must be booked at least 48 hours before departure, via the relevant airline or travel agent.
A shuttle bus connects the airport to Lille-Flandres railway station in 20 minutes (fare: €8).
For more information, visit: www.lille.aeroport.fr/getting-to-the-airport/parking/ and www.lille.aeroport.fr/getting-to-the-airport/road-map/
The airport has wide automatic doors and accessible toilets and lifts.
Getting to Lille by rail
Lille has two main railway stations: Lille-Flandres and Lille-Europe. Both stations offer connections to numerous cities in France, as well as abroad: Belgium, the Netherlands and the United Kingdom.
To book a wheelchair space, please visit www.sncf.com/en/services/handicap/information-booking
If you require assistance during your journey, you must book this with Accès Plus at least 48 hours before departure (see contact details below). You should arrive at the station at least 45 minutes before departure and go to the Accès Plus office. The staff there will contact their colleagues at your destination station to ensure they are prepared for your arrival.
Tel. +33 (0)890 640 650
Email: firstname.lastname@example.com
Web: www.voyages-sncf.com/services/acces-plus (French only)
If you are travelling with other operators, CAFE advises you to book assistance as early as possible.
Getting to Lille by bus
Several coach companies provide buses to the tournament host cities and vehicle accessibility may vary. CAFE advises disabled supporters planning to travel by bus to discuss their specific access requirements with their travel provider before booking.
SNCF offers inter-city bus services that include accessible vehicles. It is advisable to book in advance and explain your specific access requirements at least 48 hours before departure. Levels of accessibility may vary.
For more information and to book your tickets, visit: www.ouibus.com/persons-limited-mobility


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News editor
CiboTech owner Dan Madgwick has resolved a lawsuit over his plans to open a lab in Marion to examine contaminated food and is going forward with his plans.
Madgwick said the lawsuit by his former employer, Alteca Ltd., was settled Nov. 19. He is satisfied with the results, but will have to change his business plan slightly in the short run.
"In a settlement, there's give and take," Madgwick said. "We're just excited to be able to jump back into things and proceed as planned."
He said the terms of the settlement won't substantially affect his long-term plans. He will gradually add equipment and capabilities to his lab, and he should be able to start accepting some business from restaurants and food companies as soon as the start of 2014.
"It's neat to see this dream kind of realized finally," Madgwick said.


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The JBL EON612 is a true step forward in technology developed specifically to deliver the best sound possible regardless of its application. Completely rethinking how truly good an affordable self-contained, portable PA system can be, JBL engineers purposely designed and built the EON612 from the ground up featuring JBL's advanced waveguide technology, JBL designed and manufactured transducers, and convenient, wireless remote control of its onboard DSP EQ parameters via Bluetooth.
This total redesign of the EON platform leverages the latest technologies in cabinet materials, acoustic science, transducer design and user friendliness that delivers the extraordinary quality of a high-end studio monitor in a fully professional, highly flexible, easy to use, portable system for today's working musicians and sound providers.CALIFORNIA PROPOSITION 65 WARNING WARNING: Cancer and Reproductive Harm - www.P65Warnings.ca.gov.
MSRP: $143.99 Save: $54.00 (38%)
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What started as a simple string and pedal sales catalog has grown exponentially over the past thirty years. The early days were a time where catalogs didn't have much of a presence in the industry, but what began as a college dorm room operation grew rapidly. In 1986 we moved to a full product offering and 64-page catalog, which over the years has grown to 162 pages. Join the AMS family and get your free catalog now!
Copyright © 1996-2019 American Musical Supply, Inc. All rights reserved. American Musical Supply reserves the right to correct pricing and/or product specifications in the event of typographical errors found in our print catalog or on our website. If a product is listed at an incorrect price due to such errors or because of inaccurate information received from a supplier, American Musical Supply shall have the right to refuse or cancel any orders placed, whether or not the order has been confirmed and your credit card charged. If your credit card has already been charged for the purchase and your order is canceled, American Musical Supply will issue a credit to your credit card account in the amount of the charge.


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GHC News Flash: Global Health Roundup – 04/09/2018
NCD Child Encourages Young Minds to Participate in Global Art Contest
On April 3, ahead of World Health Day (April 7), NCD Child launched a global art and video contest for adolescents to visually highlight the importance of non-communicable disease (NCD) prevention and control for young people and their communities. Based on the theme, Health For Youth = #HealthForAll, the contest invites artists between the ages of 12 and 21 to electronically submit original drawings, paintings, or videos. Finalists will be formally recognized at a ceremony during the 2018 United Nations General Assembly (UNGA) meeting in New York City. The contest is supported by a grant to NCD Child and the American Academy of Pediatrics from Novo Nordisk. Deadline for submissions is May 31.
World Health Worker Week Elevates the Voices of Real Changemakers
The Fifth Annual World Health Worker Week (WHWW) took place last week (April 2 -8), with several events occurring in the Washington, DC area. OnApril 2, IntraHealth International and Frontline Health Workers Coalition (FHWC) co-hosted a Twitter chat to highlight health workers who are influencing policy change and to generate ideas to help health workers become more effective advocates. On April 5, FHWC, the United Nations Foundation, and Johnson & Johnson hosted a Health Heroes + SocialGood summit, which re-invigorated a vital call to action to support and empower health workers worldwide. Follow up on all of the WHWW social media conversations using the hashtags #HealthHeroes and #HealthWorkersCount. Also, view FHWC and IntraHealth International blogs, which amplify the voices of health workers who are creating powerful changes in their health systems. Next up on the World Day circuit is the International Day for Maternal Health and Rights on April 11. Consider joining a blog carnival to champion maternal and reproductive health advocates.
New Global Health Fellow Program (GHFP) II Crossover Study Seeks Participants
Last month, Global Health Fellows Program (GHFP) II launched a qualitative study to identify the motivations, challenges, and successes of a unique group of professionals who have experienced a "crossover" between their global and public health careers. Previous research shows that most health professionals stay in their area of specialty throughout their careers. Moreover, there is significant evidence of domestic health professionals finding it difficult to transition into global health work. This study will explore the experiences of select professionals, especially those who were able to successfully move from domestic public health to global health work. If you are interested in participating and want to see if you qualify for the study, please complete this survey by April 27.
1) March 26: Organizers of the 2018 Global Health Mini-University, an annual, one-day learning forum bringing together global health professionals and students, announced calls for sessions proposals to shape the event. Deadline for submission is April 20.
2) March 29: CORE Group opened registration for its first post-conference workshop following the Global Health Practitioner Conference (to be held in June 2018), focusing on the integration of NCDs into global health programs.
3) April 2: PATH's Defeat Diarrheal Disease Initiative and partners announced, Take the Plunge, an interactive experience that will enable advocates to explore the solutions that ensure children survive childhood and reach their full potential.
4) April 2: A new PBS film, Global Health: Preventing Pandemic, will be screened in New York later this month at an event hosted by Friends of the Global Fight Against AIDS, Tuberculosis and Malaria and Rabin Martin as well as in Washington, DC, at the Center for Strategic and International Studies' headquarters. The screenings will be followed by panel discussions by global health experts.
5) April 3: WHO updated its position paper on typhoid vaccines to formally recommend the use of the first typhoid conjugate vaccine (TCV) in routine immunization programs of typhoid-endemic countries.


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Ohio Safety Congress & Expo
Ohio Safety Congress & Expo
BWC's Ohio Safety Congress & Expo will be held March 11-13, 2020, at the Greater Columbus Convention Center
BWC's Ohio Safety Congress & Expo offers more than 200 educational sessions, 250 exhibitors, and free continuing education credit. By attending the safety congress, you will learn to:
- Prevent workplace injuries and illnesses.
- Achieve better outcomes for injured workers.
- Reduce workers' compensation claims costs.
- Keep Ohio's work force healthy and productive.
Registration is free.
If you have any questions, please call 1-800-644-6292.
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or make 4 interest-free payments of $25.00 AUD fortnightly with More info
Cricket Trophies Customization Options :
Cricket Fieldsman
- Standard Engraving Charges for Trophies are:
- Number of Items - Repeat Message - Variable Message
- 2 to 4 - $3.30 - $4.40
- 5 to 9 - $2.20 - $3.30
- 10 to 19 - $1.10 - $2.20
- 20 to 49 - $0.55 - $1.10
- 50 to 99 - $FREE - $0.55
- This allows for 3 lines (up to 45 characters) to the same size plate
- Repeat message means the EXACT SAME message on all items
- Variable message means a NAME, DIVISION or CATEGORY is different on each trophy
- Lists for variable messages on 10+ items needs to be supplied on the excel
- ORDER FORM or surcharge for typesetting applies
- LOGO SETUP - $22 if order UNDER $250. For orders over $250 no setup fee.
- Order over $250 setup FREE
- A popular addition to trophies where there is a recessed circular area.
- Setup $22 on Orders under $250. For orders over $250 no setup fee.
- Inserts $1.10 each, on Orders Total $2,500+: $0.55 each, on Orders Total $5,000+: FREE
Knocking Policy
Knocking-in a bat is a very essential and vital process to ensure its longevity and get the best performance. Cricket Bats are expensive items and it is important to take good care of it. Knocking-in process reduces the chances of a crack in your bat by 80%.
Knocking-in process, if done by hand using a wooden mallet, typically requires about 18-20 hours of knocking. To save the time and energy of our customers, WHACK Sports uses a fully automated machine to knock in the bats. The bat will be ready to use in 45 minutes.
Our knocking machine is designed with modern day technology with option to preset the desired number of knocks. It knocks in the bat thoroughly. The moving rollers ensure that it covers the toe, edges and the blade. We give 15,000 knocks to every new bat and no further knocking is required after that.
For details visit our page https://whacksports.com.au/pages/knocking-in
There is no certain time a cricket bat will last. Cricket bats are made from willow which is a natural material and it is repeatedly hit with a hard cricket ball. Deterioration and a small amount of cracking are normal & inevitable. This shouldn't bother you and have any impact on the performance of the bat.
Subject to the terms and conditions, WHACK Sports agree to repair or replace your gear in circumstances where it's deemed to be manufacturer's fault. All cricket bats sold by us are subject to a discretionary 12-month from the date of purchase (including replacement bats), manufacturers' warranty for any damage deemed not to be the fault of the purchaser. When the manufacturer has inspected the item and reached a conclusion concerning the warranty claim, the customer will be notified of the outcome - being either the item repaired, credited for replacement/exchange or the warranty claim being refused. Please note that minor wear and tear and surface cracking to a bat does not constitute a warranty claim and is a common occurrence that does not affect the performance.
Please visit our page: https://whacksports.com.au/pages/warranty-and-returns for details on what is/is not covered
Domestic Postage:
Postage cost will vary by the total order amount, weight and selected method of delivery. WHACK Sports provides service by Australia Post and Fastway Couriers for all domestic postage, and DHL and Australia Post for international deliveries.
Orders Above $200 qualify for FREE Shipping Australia and New Zealand Wide.
A Flat fee of $9.99 is charged for orders below $199
International Postage:
For orders placed from outside Australia (except New Zealand), international freight charges will apply. Overseas deliveries may be subject to import charges and other local taxes for which customer would be liable. Customs restrictions may also apply.
Note: For detailed cost of International Shipping and Domestic Express Shipping, please visit our page: https://whacksports.com.au/pages/free-shipping
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LawsuitPool Takes The ALS Ice Bucket Challengeon August 26, 2014 at 12:01 am
Greetings, everyone! Ash Green of Plan X Media has–okay, you know what, it's 9:15 PM and I haven't even fixed dinner yet. Watch Ash's Ice Bucket Challenge, in which he challenges me and LawsuitPool:
I donated to the Midwest Stem Cell Therapy Center (which conducts is research using only adult stem cells). LawsuitPool…well, didn't.


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NU BnB
Graduate and commuter students have the option of residing on campus in a residence hall on a nightly basis with a two consecutive night maximum each week. Rooms are available on a first-come, first-serve basis. Packages are available as follows:
- 1 night - $40
- 5-night package - $175
- 10-night package - $320
- 15-night package - $450
- 30-night package - $810
Our program is currently offered only during the academic year. Please note that all reservations must be made one week in advance of requested date.
Please call the Office of Residence Life at 716.286.8566 with any questions.
All rooms are singles with private baths in the hallway. Rooms are furnished with a standard twin bed, wardrobe, desk and desk chair. Local telephone service is available if you provide your own phone. Outlets for computer and cable service are also available in each room. We encourage students to bring their own bedding (pillow, blankets, sheets) and bath towel, since they are no longer provided.
Lynch Hall has a study lounge located in the basement with a TV, kitchenette, recreation/game room and a gym. All residents have access to vending machines and (no charge) laundry facilities.
Community Advisors and Security
One community advisor (CA) is available on each floor of Lynch Hall. The CAs are student staff members who supervise the floors and are responsible for promoting a healthy living/learning environment. They are available to answer any questions and to assist you in acclimating to your living situation.
The Lynch and O'Donoughue Hall front desks are manned by CAs. Residents must present a college I.D. to enter the building. Visitors must sign in and be escorted by their host.
The room rate does not include a meal plan but several options for meals are available. Details can be found here.
The NU BnB program is not available during the time campus residence halls are closed. For a complete hall closing schedule, please visit http://www.niagara.edu/residence-hall-schedule/