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If you've got a slow cooker, follow the same procedure but allow it to cook for as long as you can be bothered (I normally do it overnight). You really get a ridiculous bang for your bud this way. Prepare for quite a smelly house though.
Pretty good stuff except Samuel L. Jackson says that the shit separates because "oil is thicker than water, the water will separate from the motherfucking water and gather on the motherfucking surface." This is fucking wrong. They separate because of hydrofuckingphobicity. Learn the motherfucking chemistry. That being said, the butter rises to the top because of motherfucking "thickness" (density). Motherfucking Royale with Butter.
Thanks http://www.goodandbaked.com!!!!!


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Ms. 'Splosion Man - Steam Trailer
Ms. 'Splosion Man has finally sploded her way on to Steam!
Ms. 'Splosion Man has finally sploded her way on to Steam!
Here's the announcement trailer for Ms. 'Splosion Man, coming soon!
These are GameSpot's nominees for the Best Platformer of 2011.
We talk to the head of Twisted Pixel about some of the cool merch available for Gunstringer, Ms. Splosion Man, the Maw, and others at PAX 2011!
This week, arcade brings you From Dust and Bastion, and Shaun White Skateboarding is available on demand.
This week, we check out Warhammer 40,000: Kill Team, Boulder Dash-XL, and a Catherine demo.
We've got hammers, boulders, ganja, and sheep. It's This Week on Xbox!
Ms. 'Splosion Man blows up this video review with Carolyn Petit.
Jody brings you the latest on Sony's indie endeavors, the HotSpot, a Resistance 3 preview, and more!
Check out some co-op action in this gameplay clip for Ms. 'Splosion Man.
Ms. 'Splosion Man gleefully splodes, solves puzzles, and quotes songs.
Ms. 'Splosion Man infiltrates and explodes a defense grid.
A mechanical monstrosity meets its match.
This week is all about football, magic, air-murder fitness, and lady bombs.
GameSpot staff members share stories of their childhood fireworks mishaps, offer some grilling tips, and talk about the games you should be playing this weekend.
Ms 'Splosion Man gameplay from the GameSpot Live stage show on the E3 2011 show floor.
Ms 'Splosion Man gameplay from the GameSpot Live stage show on the E3 2011 show floor.
Chris Watters gives you this Splodetastic demo of Ms. Splosion Man from E3 2011.
Check out a gameplay trailer for Ms. 'Splosion Man.
Sophia Tong sits down with Josh Bear to talk about Ms. 'Splosion Man during GDC 2011.
We get a lengthy demo for Ms. 'Splosion Man at GDC 2011.
Our buddy 'Splosion Man gets a companion!
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The first word: Bracketology in November just seems silly.
This season, we tried a different approach.
As the 2013-14 season tips off tonight, we embrace for waves of change on the college hoops landscape. So instead of just selecting the 68 projected NCAA tournament teams in the preseason, we took an in-depth look at each conference and each team we predicted to make the field.
NCAA TOURNAMENT: Breakdowns for all 68 projected teams
ONE STOP SHOP: Previewing the 2013-14 season
Sure, there's no RPI or strength of schedule to base this completely hypothetical forecast on. But now we're well informed so when the always highly-debated discussion (which teams will be dancing in March) starts to become more important than that project at work or your taxes, we'll have the answers.
Bracketologists around the country base predictions on numbers and the habits of the selection committee. We'll be doing all of that, too. But the one factor that seemed inappropriate to ignore for a preseason bracket is the human element, meaning: What's the moral/team chemistry of the team? Can this team overcome adversity if the injury bug hits? Which player is the X-Factor difference-maker? What strength (be it rebounding or accurate perimeter shooting) could lift teams to a win? What weakness (be it too many turnovers or inexperienced talent) could hinder an otherwise title-contending team?
STAR WATCH: 12 most exciting players for 2013-14
A glimpse at the Dance: After talking with team personnel and conference experts, we look at what the field would look like should the NCAA tournament committee select the 68 teams in November. Of the teams we analyzed 68-1, a look at bracket based on NCAA rules. Note: 2014 NCAA tournament dates and sites were not factored into this mock bracket.
Dates: First Round at Dayton (March 18-19). Second and Third Round at Buffalo, Milwaukee, Orlando, Spokane (March 20, 22) at Raleigh, San Antonio, San Diego, St. Louis (March 21, 22). Regionals: South at Memphis, West at Anaheim (March 27, 29) East at New York, Midwest at Indianapolis (March 28, 30). Final Four at Dallas (April 5). Championship at Dallas (April 7).
Last four in: Boise State, Indiana State, SMU, Arizona State.
First four out: Pittsburgh, Utah State, California, Missouri.
Next four out: Massachusetts, Southern Mississippi, Ole Miss, Providence.
Seeding: A breakdown of how it all shook out.
No. 16 seeds (Play-in games): No. 68 Robert Morris, No. 67 Charleston Southern, No. 66 Northwestern State, No. 65 Norfolk State,No. 64 Georgia State, No. 63 Boston U
No. 15 seeds: No. 62 Vermont, No. 61 Texas Southern, No. 60 Elon, No. 59 Manhattan
No.14 seeds: No. 58 Toledo, No. 57 Towson, No. 56 Florida Gulf Coast, No. 55 Weber State
No. 13 seeds: No. 54 Long Beach State, No. 53 Eastern Kentucky, No. 52 Wright State, No. 51 Denver
No. 12 seeds (Play-in games): No. 50 New Mexico State, No. 49 Louisiana Tech,No. 48 Boise State, No. 47 Indiana State, No. 46 Southern Methodist
No. 11 seeds(Play-in games): No. 45 Arizona State, No. 44 San Diego State, No. 43 Maryland, No. 42 BYU, No. 41 Cincinnati.
No. 10 seeds: No. 40 LSU, No. 39 Iowa State, No. 38 Stanford, No. 37 UNLV.
No. 9 seeds: No. 36 Oregon, No. 35 La Salle, No. 34 Villanova, No. 33 Wisconsin.
No. 8 seeds:No. 32 St. John's, No. 31 Harvard,No. 30 Notre Dame, No. 29 Baylor.
No. 7 seeds: No. 28 UCLA, No. 27 Saint Louis, No. 26 Indiana, No. 25 Georgetown.
No. 6 seeds: No. 24 Virginia, No. 23 Iowa, No. 22 Gonzaga,No. 21 Colorado.
No. 5 seeds: No. 20 Tennessee, No. 19 Creighton, No. 18 Wichita State,No. 17 New Mexico.
No. 4 seeds: No. 16 Marquette,No. 15 Virginia Commonwealth, No. 14 Connecticut,No. 13 Memphis.
No. 3 seeds: No. 12 Ohio State, No. 11 North Carolina, No. 10 Syracuse, No. 9 Oklahoma State.
No. 2 seeds: No. 8 Florida, No. 7 Michigan, No. 6 Arizona,No. 5 Louisville.
No. 1 seeds: No. 4 Duke, No. 3 Kansas, No. 2 Michigan State, No. 1 Kentucky.
The last word: Off all the information we've garnered with coaches, here's what the most important as we head into the season:
— Preseason No. 1 Kentucky is deserving of that ranking based on talent — six McDonald's All-Americans — but coach John Calipari continues to pump the breaks, mentioning the "learning curve" and saying "having great players doesn't guarantee wins. How well we come together will." Expect next Tuesday's showdown with Michigan State to show us just how cohesive this youthful unit has become in a short time.
— Conference realignment certainly shook up the landscape and Notre Dame coach Mike Brey tells us he thinks the restructuring of the Big East and American Athletic positions the Atlantic Coast Conference (the Irish's new home mind you) by far and away the best conference (over the Big Ten) and that "the ACC is going to ACC is going to morph into the old Big East as far as getting 7, 8 or 9 NCAA tournament bids consistently. It will become THE league in the next couple of years. It will be the best in it's first season, even before Louisville gets here." Meanwhile, Syracuse's Jim Boeheim sees it as "going from a very tough league to another tough league."
— Kansas freshman Andrew Wiggins was deserving as the No. 1 prospect in the country, but coach Bill Self cautions Wiggins and KU fans on expectations for a teenager who can prove his value outside of highlight reels and stuffed stat sheets. Meanwhile, the other must-see freshman in Duke's Jabari Parker could be the most valuable to his team based on the 6-8 forward's versatility to play at multiple positions.
— Star power is at an all-time high this season, and much of that is hinged upon the hype of the freshman class. But key returners such as Oklahoma State's Marcus Smart, Creighton's Doug McDermott, Michigan State's Gary Harris and Louisville's Russ Smith all make their respective teams conference title contenders and some of the best teams in the country.
Scott Gleeson, a national college basketball writer/producer for USA TODAY Sports, is on Twitter @ScottMGleeson.


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I am writing concerning the way the city of Lancaster and and the county responded to the recent snow and ice storm. The roads in Lancaster were in bad condition. Some form of salt should have been applied to the roads earlier. Even dirt would have been better than nothing.
It is time for a change. The schools were closed all week due to this. There has to be a better way to take control of the situation. Where we live, we were stuck in our own yards for two days. I was unable to go to work until Friday.
If you currently subscribe or have subscribed in the past to the The Lancaster News, then simply find your account number on your mailing label and enter it below.
Click the question mark below to see where your account ID appears on your mailing label.
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Each Limited Edition Giclee is hand highlighted with paint by the artist himself, creating no two exactly the same. Custom sizes are available.
For your opportunity to own an authentic Brent Heighton Limited Edition Gicleé on Canvas, contact Charmaine Pratt at (403) 703.5078, firstname.lastname@example.com
Cafe De Vins44 x 32
Limited Edition Giclee Available


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Owner Chip Ganassi unloaded the car to beat at Daytona International Speedway, and darn if it didn't perform up to expectations.
DAYTONA BEACH -- Owner Chip Ganassi unloaded the car to beat at Daytona International Speedway, and darn if it didn't perform up to expectations.
Ganassi's No. 01 BMW Riley was fast in practice, won the pole and then ran away with Sunday's Rolex 24 At Daytona, giving both the team and road-racing veteran Scott Pruett five overall wins in the sports-car classic.
On paper, the race looked competitive, creating a record 78 lead changes. But looks can be deceiving. Ganassi's two Daytona Prototypes led 573 of the 709 laps. Juan Pablo Montoya won by 21.922 seconds, despite 16 yellow flags, including one that lasted more than an hour Sunday morning for thick fog.
Pruett's victory tied Hurley Haywood's Rolex 24 record of five overall victories. Haywood was this year's grand marshal, after making his 40th Rolex 24 start in 2012. Four of Pruett's overall wins have come for Ganassi.
"We wanted to give these guys every opportunity to win," said Ganassi, who has won five 24s in 10 years. This year's winning team – Pruett, Montoya, Memo Rojas and Charlie Kimball – averaged 105.122 mph.
Pruett has four other class wins in the twice-around-the-clock event, which started Saturday afternoon before an estimated crowd of 45,000, and ended on a cool, sun-splashed Sunday in front of about 35,000 fans.
"It's unbelievable," Pruett said. "This is nothing short of incredible."
Ganassi made sure his Daytona Prototypes didn't show their entire hand at Grand-Am's preseason Daytona test three weeks ago.
"We knew we had good cars," he said. "Everybody wants to keep some things in their pocket before they race."
Montoya did the last stint in the race-winning Daytona Prototype, which covered 709 laps over the Speedway's 3.56-mile road course.
There were four caution periods in the final two hours, while Montoya was behind the wheel, trying to close out the victory.
"It wasn't a lot of pressure at first, then there was a caution, another caution, another caution," Montoya said of closing the deal Sunday. "I took my time to pass people. We pushed like crazy at the end to open a gap, and it was fun."
Montoya, part of Ganassi's NASCAR Sprint Cup Series team, and Pruett were joined in Victory Lane by co-drivers Rojas and Kimball, making his first start in the Grand-Am Rolex Series.
The No. 10 Wayne Taylor Racing Corvette DP was second, followed by last year's race winner, the No. 60 Michael Shank Racing Ford Riley, which rallied back from a mechanical problem and seven laps down in the first hour of the race to earn a spot on the podium.
The second- and third-place teams complained about and complimented Ganassi's advantage this weekend.
"It's so obvious, so unfair," No. 10 co-driver Max Angelelli said. "Montoya and the No. 01 car are another league, in an 'A' class. We are 'B' class."
AJ Allmendinger, who led the No. 60 car to victory in 2012, tried to hold off Montoya late, but he could not contain the mighty No. 01.
"I knew he was going to get by, I was just going to make him work for it," Allmendinger said. "They had the cars to beat, for sure. They did their homework."
Rounding out the overall top five were the No. 9 Corvette DP, which was piloted by Ormond Beach's Joao Barbosa, and the No. 90 Spirit of Daytona Corvette.
The GT class was won by the No. 24 Audi R8 driven by Filipe Albuquergue, Oliver Jarvis, Edoardo Mortara and Dion von Moltke.
The No. 16 Porsche Cayman, wheeled by David Donohue, Shane Lewis, Jim Norman and Nelson Canache, captured top honors in the new GX class.


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Letterpress Video at Studio On Fire
Gestalten TV was in our studio and put together a great video. You can get the podcast on itunes here.
For their visit, we had a little project on press called "The Pressroom Creed" - printing on 220lb Lettra and will be available soon for sale on our site. It is an adaptation of the better known Rifleman's Creed, but for letterpress printers. Seriously, everyone in our pressroom must memorize this and we say it together each morning.


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Good mood food
A simple way to feel better and tuck into something delicious.
Whether you prefer yours Japanese-style as sashimi, smoked and in a bagel or baked with herbs, salmon is a tasty way to improve your mood. This healthy fish is packed full of omega 3 fatty acids. These are associated with your brain and helping your cognitive functions. Memory function is one area for which omega 3s are believed to be vital. There's also evidence that they can help reduce depression. Plus, salmon is an excellent source of vitamin B12 which aids the production of 'happy hormone' serotonin.
Popeye was definitely onto something with his love of these leafy greens. Spinach is bursting with folic acid, magnesium and vitamins A and C, all of which are connected with improving your mood. "Lack of iron and folate can make you feel weak and lethargic," says dietician Priya Tew. "A lack of folates in your diet increases your risk of feeling depressed, so eating green vegetables like spinach would help improve your mood." Magnesium has a wealth of health benefits, too, including being a natural sleep aid and helping to control stress.
Don't worry, we're not about to tell you that the way to happiness is by drinking raw eggs! But make sure you include eggs in your diet one way or another. Their high protein content keeps you feeling full and alert, and eggs also contain omega 3, zinc, B vitamins and iodide, which is useful for maintaining healthy teeth, hair, nails and thyroid function. The previously shunned yolk is in for a comeback, too, as it's packed with vitamins D and B12, perfect for getting those serotonin levels up. "D vitamins definitely have an impact on your mood, and are involved in energy release," says Tew. "Getting a steady release of energy will improve your sense of wellbeing and happiness."
Good news for everyone tired of hearing bad things about red meat – the high iron levels found in meats like beef and lamb encourage production of the mood-regulating brain chemical dopamine. Studies suggest that the iron-deficient among us (a common problem for women) could be more likely to su er with depression. Red meat is also a great source of B vitamins and protein. But vegetarians shouldn't worry: good old spinach is a strong source of iron, too.
This cheap and popular herb doesn't just add flavour to your cooking – it has a long list of health-enhancing qualities too. For starters, it increases blood flow around your body, boosting both energy and mood. Eaten raw, whether whole or chopped up into a salad, garlic boosts serotonin levels and overall wellbeing. Just be sure to pocket some minty chewing gum if you do make a habit of chomping on raw garlic…
Moules frites, anyone? Mussels have some of the highest levels of vitamin B12 in any known food. This wonder vitamin has been found to help reduce depression, stress levels and brain shrinkage. The shellfish also contains a calming cocktail of iodine, zinc and selenium which are vital for keeping your body's mood master – the thyroid – working properly. Plus, mussels taste great with a glass of white wine which (in moderation of course!) will give you an additional dose of antioxidants.
It's true what they say about eating chocolate making you feel better – the combination of its smooth texture and sweet flavour releases mood-elevating endorphins. Not that we needed an excuse! "There hasn't been any hard evidence of this," says Tew. "But they do release serotonin into your brain, which can improve your feelings of happiness." The health benefits only really apply to dark chocolate, with at least 60 per cent cocoa content. Unlike the sugary milk version, dark chocolate is lower in fat and sugar and also contains antioxidants.
Long heralded as the ultimate hangover cure, and a fantastic low-calorie snack, bananas truly are one of nature's candies. Their natural sugars make them deliciously sweet (yet without the fat and cholesterol found in many sweet treats) and also help the body produce serotonin. Like spinach, the high levels of magnesium found in bananas are credited with aiding sleep and reducing anxiety. Plus, they're a strong source of potassium which, as well as being important for nerve and muscle function, can also help reduce anxiety and stress.
Even if you don't pretend you're in Florida every time you eat an orange, their vitamin C levels are great at putting a sunny smile on your face. Your body reacts to the smell and taste of oranges to encourage serotonin production. As well as boosting your immune system and helping keep bugs at bay, vitamin C lowers blood pressure and stress levels. Kiwis are another fruit packed with that all-important C vitamin.
Through their iron and folate levels, fruits and vegetables are very important for overall physical and mental wellbeing, but carbohydrates are also important – and wholegrains are especially beneficial for maintaining stable moods. "Wholegrain foods such as wholemeal bread and brown rice contain B vitamins," says Tew. "These are definitely shown to be linked to mental wellbeing and decreased risks of depression."


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Woodmere resident Alli Berman, who has had the flu for more than a week, received the flu vaccination from her physician in mid-November and thought she would avoid the flu epidemic until she attended a family function earlier this month.
"I thought I dodged a bullet," she said. "But three people were very ill and showed up because they couldn't miss the event but I got sick the next day and have been on antibiotics ever since."
Berman was bed ridden for two days and has been taking vitamin C, eating chicken soup and adding garlic, which is a natural food that helps throat pain, into her diet wherever she can. "I've been thrown for a loop and I feel like there is no end in sight," she said. "I have things I have to do and I cannot afford to be sick."
Cedarhurst-based Dr. Marc Sicklick said he has been seeing more patients suffering from the flu, including those who have complications due to asthma. "Anyone who has any underlying respiratory or cardiac problems, any immune issues or any other risk factor for increased complications should immediately contact their primary care physician," he said. "The biggest mistake is saying that 'it's just the flu.' It's better to be seen for no reason than not to be seen an regret it afterwards."
Influenza, or the flu, is a contagious respiratory illness that can cause fever, cough, sore throat, runny or stuffy nose, muscle or body aches, headaches and fatigue, according to Dr. Michael Stuart, chief medical officer of USA Hockey. "People with the flu are contagious from the moment they begin feeling sick until at least three days after they recover," he said in a statement. "But some people are contagious for even longer."
Dr. Rajiv Prasad, chairman of Emergency Medicine at St. John's Episcopal Hospital in Far Rockaway, said the hospital has only seen a slight increase in overall volume of patients with the flu. "It's not as much as the rest of the city," he said.
Prasad said prevention is key to beat the flu and anyone over six months old, including pregnant women, should get vaccinated. "It takes about 10 to 14 days for peak immunization to develop," he said. "If someone in their home has the flu, a person can go to their doctor or the emergency room to get medication that will prevent or diminish their risk of getting it. If someone has the flu they can take medication within the first 24 to 36 hours that will reduce their symptoms."
To prevent getting the flu, Prasad recommends avoiding exposure to someone who has it as particles are expelled into the air when a person sneezes or coughs and wash your hands frequently. "If you're sick, you should not go to work or school to prevent exposing others," he said. "And get plenty of rest, fluids and take ibuprofen."
Hewlett-Woodmere Public Schools has seen an increase of flu cases and flu-like symptoms in the past few weeks, according to Nurse Coordinator Bonnie Rashbaum. "Since the epidemic of swine flu [in 2009] our schools have installed hand sanitizer wall units located throughout each building, as well as signs to remind students and staff to wash their hands," she said. "It is also stressed to cover mouths and nasal airways when coughing or sneezing."
Classroom teachers may send students who are coughing and sneezing in class to the nurse's office, according to Rashbaum, who then evaluates each child and calls their parents, if needed. "Parents are encouraged to take their child to their primary care physician for further evaluation and are told to keep their child home until they are symptom-free for 24 hours or per their medical professional advice," she said.
Prasad said primary care doctors' office and pharmacies are the best places to receive flu shots. "We don't recommend that people go to the emergency room to get it as they are overcrowded; it's not the right place," he said. "Your primary physician as well as pharmacists can administer the flu


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Sorry! This giveaway is now closed. We would like to congratulate HEATHER F. (Comment #71) on winning this prize!
I am so excited to share another great giveaway with our readers for a year's supply of Minute Maid Pure Squeezed! We have shared everything with you from tips on throwing your own orange-themed party to what to keep on hand for all of those holiday guests. Of course, for both of those parties, I recommend adding Minute Maid Pure Squeezed orange juices or orange juice beverages to your must-have list.
Today we are offering one lucky reader a year's supply of Minute Maid Pure Squeezed. Leave one comment for each item that you complete to enter:
• First Entry: Leave a comment and let us know which variety of Minute Maid Pure Squeezed you are interested in trying for your family- No Pulp 100% Orange Juice, No Pulp 100% Orange Juice with Calcium and Vitamin D, Some Pulp 100% Orange Juice, or Light Orange Juice Beverage with Calcium and Vitamin D with 50 calories per 8 fl. oz. serving.
• Additional Entry: Let us know you are a fan of Minute Maid and join the Minute Maid Facebook Page.
• Additional Entry: Follow me on Twitter and get an early scoop on what I am up to and future giveaway opportunities with Minute Maid!
One winner, chosen at random, will receive a year's supply of Minute Maid Pure Squeezed (52 coupons). Please submit your entries by Tuesday (12/06) at 8PM EST. Our winner will be drawn at random. Good luck, everyone!
I am a spokesperson for Minute Maid Pure Squeezed and have a relationship with the company. Want to know more about how things are handled here at MomAdvice? Be sure to read our Disclaimer which clearly states how things work and know that we will always offer only the best reviews to our readers. In full disclosure, the email addresses that are collected for this giveaway will only be used for the purpose of contacting the winner(s), and will never be sold or given to anyone. This giveaway is only open to residents of the United States who are 18 years of age or older. Entries that do not follow the above criterion will automatically be disqualified. This giveaway will close Tuesday, December 6th at 8PM (EST). I'll announce the first name of the winner(s) that will be added to the top of this current giveaway post and contact the winner(s) by email. I will draw the names of the winner(s) by using the random number generator at Random.org from the eligible entries received. If a winner does not contact me within 72 hours by email, I will draw a new winner. The winner(s) will receive their prize from the PR agency responsible for this giveaway.


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"Bet's" by BunnyofDeath
Categories: Fairy Tail
Characters: Reader
Description: Just a think I wanna do and hope others will to.
Posted: 06/14/13 | Deadline: None
All fan fiction represented in this archive are © their respective owners and/or authors. All original works are © their respective authors. No reproduction of the written works in this archive is permitted without prior consent of their respective authors. All Rights Reserved. Icons used on this site are from famfamfam.com. Protected by Spam Poison Bleach, Ichigo are © Studio Pierrot, TV Tokyo, Dentsu, and Tite Kubo.


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Relapsing-remitting MS
Relapsing-remitting MS affects about 85 percent of people with MS. One or more symptoms described above flare up (this is the relapse) and then improve somewhat or completely (remit). During a relapse, new symptoms appear or old symptoms worsen. During remissions, the disease does not seem to progress. The duration of relapses and remissions varies from person to person.


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CHICAGO (AP) — Illinois Gov. Pat Quinn's new running mate says he has a strong record on education, taxes and collective bargaining agreements.
Paul Vallas appeared with Quinn for the first time Tuesday during a news conference in downtown Chicago.
Quinn announced Vallas as his pick in an email Friday. During Tuesday's appearance, the two say addressing the state's pension problems will be a top priority for their ticket.
Vallas, who ran Chicago Public Schools from 1995 until 2001, is leaving his job as school superintendent in Bridgeport, Conn. in order to campaign in Illinois.
He lost the Democratic nomination for governor in 2002 to Rod Blagojevich (bluh-GOY'-uh-vitch).
Quinn's current lieutenant governor, Sheila Simon, is running for comptroller next year.


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Letters to the Editor
Letter to the editor | Jim Crow rears his ugly head
The Rev. Martin Luther King Jr. was one of the most important figures of 20th century America.
He led a nonviolent movement that finally forced the government to heed the Ninth and 14th amendments. This movement was instrumental in ensuring people of color the right to vote, thus bringing most Jim Crow laws to an end.
The Supreme Court justices who recently inflicted the "Corporations are People" poppycock upon us have now brought mean, old Jim Crow back to life to work his evil by attempting to suppress the right to vote. But this time in all of the states.
Some Congress members in our own state are, at this moment, defending a Jim Crow voter-suppression law in our state Supreme Court, known as the Voter Identification Law.
Don't let the innocuous name fool you. The authentic purpose of the Voter Identification Law is misrepresented and spurious.
In 1967, with his brilliant "Beyond Vietnam" speech, King widened the civil rights movement to include the platforms of ending poverty and working toward global peace.
One year, to the day, after that speech, he was assassinated while helping to organize a workers' strike for a living wage. Today this fight for workers' rights and a living wage goes on.
Enlightened thinkers, especially the young, who would benefit the most, are sorely needed in this nonviolent fight for workers' rights, voting rights, a living wage and a national jobs creation program to put the nation back to work with dignity.
Paulette Jo Frederick, Hollidaysburg


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September 2003
A wide variety of science-based issues for teaching can be found in a newspaper. Photo: Microsoft Image.
- "Anthrax vaccine: Controversy over safety and efficacy"
- "Shanghai issues new SARS regulation"
- "US to withdraw from Kyoto Global Warming Treaty"
- "Is the Endangered Species Act in danger?"
- "Brain disease rises in deer, scaring hunters"
- "UK to approve 'therapeutic cloning'"
- "Born-again Quagga defies extinction"
- "President Bush and environmentalists disagree on forest fire policy"
One needs only to open a newspaper to identify a wide variety of science-based issues that can serve as an excellent vehicle for making science "come alive" for students. Using issues in the classroom also allows an instructor to foster the students' skills of critical analysis and life-long learning that they need to deal with the changing nature of science in society. Providing students with the tools necessary to critically evaluate and make decisions about the future scientific issues they will face is central to scientific literacy education.
First case study: reformulated gasoline issue
In an introductory course in Environmental Science for undergraduate students (primarily for non-science majors) in our College Honors program, I posed the question:
"Should the Environmental Protection Agency have waived the reformulated gasoline requirement for Milwaukee [Wisconsin] in the summer of 2000?"
Reformulated gasoline (RFG) has oxygenating additives such as ethanol or MTBE that, at least in theory, decrease harmful emissions of ozone and ozone precursors (e.g., carbon monoxide, nitrogen oxides). Cities with ground-level ozone levels in excess of acceptable levels are mandated by the EPA to use RFG. In the summer of 2000, gasoline prices soared to over $2.00 per gallon, with the increase largely attributed to the RFG requirement. In response, several local governments sued the EPA to waive the requirement due to the wide-spread economic impact resulting from the increased fuel costs, combined with questions about the effectiveness of RFG.
The issue was chosen for four primary reasons:
- The course was taught in the fall of 2000, so the issue was very current and relevant in the minds of the students. They felt a direct stake in the issue every time they put gas in their car.
The issue involved a great deal of science. Students needed to understand what gasoline is and how it is made, the basic chemistry of combustion, the by-products of combustion, the biological implications of air pollution, etc. As with many scientific issues, the issue also involved a level of uncertainty that students had to deal with.
The issue had political, economic, and social ramifications. Students recognized a key ramification when they saw gas prices soar to over $2.00 per gallon, but also came to learn about how political decisions are made and the relationship between scientific evidence and public policy.
The issue had no clear answer. This helps students to understand that there isn't always a "right" answer, and reinforces the importance of making informed decisions that are well-supported by evidence.
The unit was structured to emphasize student-led investigation. Students developed a list of what they felt they needed to understand in order to answer the question posed and brainstormed potential sources of that information. Class sessions included lectures, guest speakers, field trips, group presentations, and class discussions. Groups of students were responsible for researching topics such as:
- air quality regulations
- ethanol and MBTE
- the supply and distribution of reformulated gas
- the economics of reformulated gas
and then making presentations to the class as a whole. Class sessions were supplemented by readings from the National Academy of Sciences' report on reformulated gasoline and readings from a general environmental science textbook. Laboratory sessions during this unit investigated the effects of ground-level ozone on milkweed leaves (Asclepias syriaca), which gave students an opportunity to experience the process of scientific investigation and why uncertainty is a part of all scientific endeavor.
I assessed student learning by evaluating:
- class presentations
- participation in discussions
- laboratory reports
- final papers in which they presented their "decision" on whether the EPA should have waived the reformulated gas requirement
- a written examination on the scientific concepts introduced in the unit
It is worth noting that my own background with respect to this issue was minimal, so I was learning with the students. This was advantageous in that I could model the value of life-long learning and I could clearly empathize with their struggle to come to grips with the ambiguity of the issue. On the other hand, students would certainly have traded my empathy for more guidance as they wrestled with what was a very difficult issue.
- The "reformulated gasoline" unit pushed students to critically analyze a contemporary environmental issue.
- In doing so, they had to learn a variety of scientific concepts and also how science is done.
- Most vividly, they wrestled with the role of uncertainty in science and how that uncertainty comes to play at the interface between science and public policy.
This was a difficult and frustrating unit for many of the non-science majors. Yet student evaluations and my own impressions suggested that despite the frustration, many students found value in the experience and came to appreciate that often policy decisions need to be made when supporting data are incomplete or there is not time for more research.
Perhaps most importantly, focusing on a current issue allowed the students to work through the type of process they'll need to undertake when they are trying to analyze an issue they read in the newspaper someday, but to do so with a variety of academic support structures in place.
Second case study: zoology issues
To help students (primarily science majors) in a vertebrate zoology course build skills in finding and evaluating evidence and allow them to build connections between course material and the "real world," I assigned a series of issue discussions throughout the one-semester course. Students selected three issues during the semester about which they would become the "experts." Experts were responsible for researching the evidence on all sides of the issue, preparing a summary statement that explained the issue, using evidence to support a particular position on the issue, and, working with other experts, facilitating a class discussion on the issue.
The course was organized in units that focused on each major vertebrate class, and I assigned one issue in each unit. This constraint sometimes made it challenging to identify a strong issue about which there was true disagreement. Sample issues selected for the course included:
- "Aquatic exotics — what's the fuss?" which focused on the problems with defining and assessing the impact of introduced fish species.
- "Are birds really feathered dinosaurs?" which assessed recent evidence on the origin of birds.
- "Don't shoot Bambi — shoot his mom!" which looked at the strengths and weaknesses of various white-tailed deer herd management practices.
In their written and oral presentations, evidence of the following criteria was assessed:
- rigorous research
- a clear understanding of the issue and of the sources used
- critical thinking
- preparation and ability to teach classmates about the issue
- a logical structure to the paper and discussion
All of the students in the course agreed that the issue discussions were a valuable part of the class that helped them achieve the course objective of being able to "locate, synthesize, and discuss semi-technical scientific information about current issues in vertebrate zoology." The most common criticism of the issue discussions was that the "experts" tended to focus more heavily on presentation, rather than discussion of the material.
What makes a good issue?
An issue is basically defined as a topic with no clearly-defined single outcome or answer — something about which reasonable people might be expected to disagree. Issues can also be framed in terms of a case study, particularly those known as "decision cases" or "dilemma cases," or a problem, as in problem-based learning. Issues most useful for teaching science are characterized as "data-rich," so students have an opportunity to consider and evaluate potentially contradictory evidence, as well as to understand how that evidence was generated. Often, data sets can be extracted from published literature, to allow students to work through the same decision-making strategies as the original researchers. Issues should also make clear connections to the course objectives with respect to both content and skills, and instructors should work to reinforce and support these connections through all phases of the educational process.
Although issues with contemporary relevance often best capture student interest, some historical issues provide useful educational opportunities as well. For example, the American Biology Teacher published an article entitled, "The Tragedy & Triumph of Minamata: The Paradigm for Understanding Ecological, Human-Environment & Culture-Technology Interactions." Minamata disease is a neurological disorder caused by methylmercury poisoning, resulting from industrial waste being dumped into a marine system where there was an active fishing industry. Students could investigate a variety of biological (as well as social, political, and legal) concerns connected with this issue. Given the historical nature of this Japanese disaster in the 1950s and 1960s, students would also be able to see how the issues raised were actually resolved, one of the things that is difficult to do with contemporary issues.
Other excellent historical issues include:
- the recombinant DNA controversy of the late 1960s
- the regulation of clorofluorocarbons in the 1970s and 1980s
- the response of deer populations on the Kaibab plateau in Arizona, following the removal of major predators
- the attempt of Biosphere 2 to serve as a model of the Earth's environment
- dinosaur extinctions and the significance of Mexico's Chicxulub crater
- the spotted owl debate in the Pacific Northwest
The issues used in a science course can be simple or complex, depending on the goals of the course. The issue might be addressed in a single class session, over the course of several class sessions, for an entire unit, or even for an entire course. Issues can be taught with a heavy reliance on lecture/discussion or with the focus on independent or collaborative inquiry.
Reflections on teaching and learning with issues
In 1996, the National Research Council outlined key objectives for science literacy at the undergraduate level, indicating that students should:
- understand the basic principles used to explain natural phenomena
- connect science, mathematics, engineering, and technology to real world problems and issues
- understand the processes by which scientists, mathematicians, and engineers investigate and solve problems
- be exposed to information that is broad and current
- acquire the ability to remain life-long learners about these subjects2
This level of scientific literacy is seen as critical both for encouraging interested and talented students to pursue careers in science and for educating a citizenry prepared to critically evaluate and respond to the changing needs of society in an increasingly-technological future. "Science, mathematics, and technology are defined as much by what they do and how they do it as they are by the results they achieve."3 Given this, providing students with a strong understanding of science entails more than providing them with a body of content. We need to encourage students to ask and answer their own questions, to evaluate and use evidence, to relate historical perspectives to current conditions, and to connect scientific evidence to social and political perspectives.3 Issue-based education provides an excellent vehicle for achieving these goals.
Incorporating issues into a course requires rethinking many aspects of the teaching and learning process.
Preparation: Instructors need to search diverse media sources — including journals, magazines, the Internet, and newspapers for appropriate issues. Instructors can also take advantage of an increasing number of resources now available with prepared issues in the form of case studies or problem-based learning activities (see "learn more" links at end of this article).
Developing skills: Issue-based education should build students' core skills in:
- reading critically
- identifying important information and discriminating fact versus opinion
- identifying what is know and what is unknown
- locating and evaluating sources of evidence
- understanding scientific method and recognizing weaknesses in the design of scientific research (e.g., lack of replication, inadequate controls)
- framing data-rich arguments (e.g., using graphs effectively)
Instructors should intentionally build these skills by modeling the process they wish students to follow, or having students work on issues of increasing complexity as their skills improve.
- Leading the discussion: Student's need a "road map" for how to find the information that they need to engage in the case; this changes the instructor's role from one of gathering and disseminating the material directly. Students who feel uncomfortable with analyzing challenging data and evidence in a science-based case might tend to focus more on the social/political aspects of the issue, so instructors should be prepared to guide and direct students to achieve the objectives of the exercise. Instructors should also be prepared to relinquish a greater level of control in the classroom to give the students the freedom to wrestle with the issue in their own way.
- Assessing the outcomes: It is critical that instructors develop assessments directly connected to the objectives of the experience, which strengthens student motivation to acquire the essential analytical skills of the exercise. Structuring a formal outcome where students must make a decision and support it helps students to find closure on the issue, even if there is not a satisfactory "right answer." At the same time, a well-defined grading rubric helps students understand that they are being evaluated on the quality of their analysis, rather than on whether they agree with the instructor's views or not.
Educators in science often feel compelled to concentrate on the conveyance of vocabulary, facts, and concepts. As a result, they may rely fairly heavily on the lecture method of presentation. However, if we are truly committed to the objectives of science literacy, we need to also incorporate strategies to teach higher-order thinking skills. Issue-based education can serve that need. Dr. C. F. Herreid, Director of the Center for Case Study Education in Science at the State University of New York, Buffalo, notes that issue-based case studies in science:
"… involve learning by doing, the development of analytical and decision-making skills, the internalization of learning, learning how to grapple with messy real-life problems, the development of skills in oral communications, and often team work. It's a rehearsal for life."1
© 2003, American Institute of Biological Sciences. Educators have permission to reprint articles for classroom use; other users, please contact email@example.com for reprint permission. See reprint policy.


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You can like, use Google and stuff.
i have friends that used to be rpg players but drifted away when the fps and gta era began. fighting games went through i similar period but im not sure rpg's can make that kind of comeback without either the fps genre having a downturn or a couple series dying out. CoD/Halo
You overestimate the average American.
What RPG has a 10-word title?
Tales of Symphonia: Dawn of the New World is the longest name in that series I think, but you could also just call that game "Symphonia 2".
Well, allright, some titles are pretty weird (like Ar Tonelico Qoga: The Knell of Ar Ciel, .hack//G.U Vol 1// Rebirth), but I doubt those game would have had mainstream appeal with shorter titles.


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Every Tuesday, 7:00 PM - 8:30 PM
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Bible Study with Archbishop LeRoy Bailey, Jr.
There's No Better Time and Place to Be This Evening
Join Us Every Tuesday Evening at 7:00 p.m.
Dinner Begins at 5:30!
Every Tuesday evening, we are blessed to have Archbishop LeRoy Bailey, Jr., our Senior Pastor, lead us in Bible Study.
All are welcome to Tuesday Evening Bible Study at The First Cathedral. And don't forget to join us for dinner in the Fellowship Hall beginning at 5:30 p.m. See you then!


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When Dr. Karl Berg became part of the world's most extensive parrot research project as a doctorate student at Cornell University, he faced the challenge of recording 1,000 hours of the bird's communication at a wild parrot research center in Venezuela. In a climate that averages a stifling 95 degrees with 99 percent humidity, Berg's focus was to discover important interactions and behavioral traits among parrots in their normal habitats. To properly analyze communication habits, he needed to obtain digital recordings from inside the parrots' nests. Berg turned to the Shure SM57 and SM11 microphones, confident the mics' rugged design and quality would withstand Venezuela's tropical climate conditions.
The science community closely studies parrots, as the bird is one of few species, including humans, that uses unique "contact calls"—vocal naming skills—to communicate. "Our studies have shown that parrots' talking habits are in some ways aligned with humans," said Berg. "Contact calls serve as the sound that uniquely distinguishes each bird—it functions much like a human name."
The strong communication skills demonstrated by parrots urged Berg to document their sounds for a better understanding of the acoustic patterns and how they relate to human-like abilities. Interested in taking a more in-depth listen to the day-to-day conversations parrots have within nesting environments, Berg selected the SM57 to capture recordings. Although the microphone performed flawlessly and survived Venezuela's heat and moisture-heavy conditions, he did encounter a unique challenge.
"The physical design of the [SM]57 was mistaken for a black snake, and parrots hesitated to get close to it, wanting to avoid exposure to predator danger," Berg commented. "Changing up my game plan, I reviewed Shure's line of lavalier microphones, with the assistance of Michael Pettersen, Director of Applications Engineering at Shure, and added seven wired SM11s to my project's set-up, using a tie clasp to ensure the discrete mics were placed firmly against the parrots' nests, which I made out of PVC pipes."
Pettersen recommended the SM11 based on its history of performing successfully in outdoor applications. "The SM11 is a miniature dynamic microphone known for withstanding extreme heat and humidity without being damaged, making it a good choice for Dr. Berg's parrot research," said Pettersen. "NASA relied on SM11s for every space flight it launched, as the mic picked up shuttle sounds that triggered a vacuum bottle to collect important gas samples." The use of this acoustical gas sampling method enabled NASA researchers to save maintenance and inspection hours.
Before using Shure microphones, Berg tried a different manufacturer's shotgun mic that drew insufficient recordings because it could only be used outside of the PVC nests. "The SM11 recordings are far superior to the ones I made with a shotgun mic. Rainforests are a very noisy place, so it was critical to place the mics inside the nests, directly next to the parrots, to ensure accurate sound recordings."
Since installing the SM11s, Berg's team has reached its goal of recording more than 1,000 hours of parrot communication. He also found a new use for the SM57s — recording parrot duets, a technique where he mounts the microphone on two birds' neighboring nests to capture and synchronize back-and-forth chirping with video feeds.
"I've been very pleased with the Shure microphones," says Berg. "Their rugged nature and ability to withstand high heat and moisture for up to five months in a nest at a time has definitely given our research team a window into these parrots' lives that we were not getting before."
Shure's ability to manufacture products with a consistent level of high quality and durability is due in large part to the rigorous tests that each of its microphone models undergoes to ensure the final design performs consistently for their customers. The humidity test places microphones in a chamber set at 80 degrees with 95 percent humidity for 10 consecutive days. Hot storage and operational testing also occurs, subjecting microphones to the long term exposure of temperatures ranging from 120 to 140 degrees. If a microphone model does not pass Shure's destructive tests, it is not released into the marketplace.
Berg continues to study the parrot species with SM11s and SM57s. After receiving his Ph.D. in neurobiology and behavior at Cornell University in 2011, he became a post-doctoral researcher at University of California, Berkeley, where he currently resides.


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Follow RFF News on your cell phone. Text follow rff to 40404 you will receive txt messages with RFF News
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The next couple of Legs are going to be tough for the Racers, there is no let up for now and they will be tested yet again. I am not so fussed about big travel Legs in this third series, in fact we deliberately went for short, sharp Legs. We wanted this Race to be relentless and I think we've succeeded. So don't expect the focus to be on long travel sectors (unless it is in a bus or something like that).
This week on TARA the Race continues to be unrelenting and punishing. And, I'm sorry to say (for the Racers at least) there is no sign of a let up just yet
Okay...speculating now and just tossing this out there...The one gap we have so far in our Timeline (see page 1) so far is May 26-27--after Hue and before HK. Based on a little hint I was given and based on geographical proximity, puddin and I have been talking about TAIWAN for the missing location. Apskip---can we make it fit with flights? Vietnam to Taiwan to HK? Puddin and I think it might fit in well here...
May 26 teams are released from pitstop in a range of morning times.As leg 4 begins they fly to Taipei on eitherHUI HAN VN240 0820 0955 combined with HAN TPE CI684 1135 1510 ORHUI HAN VN244 1255 1405 combined with HAN TPE CI9024 1720 2100There is also a Hue Saigon VN251 0910 1030 connecting with BR392 1255 1730 to get to Taipei. It accomplishes nothing unless a team cannot make 0820 departure but could make 0910 or unless VN240 had no more Amazing Race Asia seats.I have also looked at flights from DaNang to both Hanoi and Saigon. They do not change much. DAD SGN VN323 1340 1450 could connect with BR396 1555 2025, which provides a 45 minute earlier arrival than the combination through Hanoi.
I have to give credit to those who thought it was stinky tofu. The things they put in there to make it. My mother says it's not good.
The episode synopsis with lots of photos is up at AXn!Not sure, but you may have to register to see:http://amazing-race-asia.axn-asia.com/season3/race/
Quote from: georgiapeach on October 02, 2008, 10:15:50 PMThe episode synopsis with lots of photos is up at AXn!Not sure, but you may have to register to see:http://amazing-race-asia.axn-asia.com/season3/race/Peach, I registered through the AXN website and receive the AXN newsletter by Email weekly. You do not need to register to see the STORY or ROUTE, but you do to see the highlights of the next episode.
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I watched it once, grabbed a glass of Scotch and watched it a second time. It is just beautiful. I understand the tremendous amount of skill and practice that goes into doing those shuffles, faros and riffle stacking so flawlessly. Well done. Very well done.
~ David
Perception of reality is a selection of reality which results in a distortion of reality.
Ha, Thanks for the kind words and enjoy that single malt!
Fantastic. I always love watching your work.
An artist makes the difficult look easy and a showman makes the easy look spectacular.
Ellusionist Lead Moderator
Ahh nice!
I love the atmosphere of the video as much as I appreciate the moves.
That's some seriously good stuff.
And look at all those cards. woot!
AtomicZebra & The Mooloolaba Shuffle
This is absolutely flawless, and if anyone wants to see some of Jason's applications of his incredible technique, I'd highly recommend his book "Confident Deceptions"
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CMLL released new on two international (related) events in the last 24 hour.
Coming up first is Noche Briticana, a special Arena Mexico show on 12/07. The announcers mentioned it in passing on last night's Terra broadcast, and Ticketmaster already has some details.
BRITISH NIGHT una lucha con causa… es un evento que están organizando la Embajada Británica y el Consejo Mundial de Lucha Libre para recaudar fondos para la Fundación John Langdon Down. Los luchadores Ultimo Guerrero y La Sombra se disputarán "Las Joyas de la Corona" en un ambiente muy británico en la cual, la arena México tendrá música y motivos ingleses. El público podrá ver y tocar el "London Bus" (el camión de doble piso inglés) y verá guardias reales dentro de la arena México. Este evento será el 7 de diciembre a las 8:30 p.m. en la majestuosa Arena México.
As you can read, it's a copromtoion with the British Embassy, and will include British music, a double decker bus, and Buckingham Palace soldiers. It sounds like an Ultimo Guerrero vs La Sombra singles main event, but I guess they could also be just leading teams.
The John Langdown Down Foundation helps children with Down's Syndrome. That weekend is the same as the annual Televisa supported "Teleton" to help special needs children, so there's probably some connection there, though it appears CMLL may be donating a different charity.
That date would seem to mean any major CMLL year end show wouldn't happen until later in December. However, there's yet to be any hint of CMLL actually running a major show in December. (I haven't seen any CMLL TV this weekend yet, so maybe you know something I don't.) It is possible CMLL says Ultimo Guerrero vs Sombra with British people is enough and calls it a year. We won't know that for certain for a few weeks, but it's possible.
In a dream world, Sombra wins the main event when new rudo faction of Rey Escorpion, Dragon Rojo, and Hooligan (british! going for revenge on his old partner!) cost Ultimo Guerrero the match. I dream too much, but Hooligan's got to be on the card. He's the only British guy they've got! Volador dressing up as one of the Sargent Pepper's Lonely Hearts Club Band alone is not going to be good enough.
CMLL & NJPW also announced the CMLL participation for the three day FantasticaMania event. Tecnicos are Mistico, Titan, La Sombra, Rush, La Mascara, Mascara Dorada, Maximo, and Diamante. Rudos are Volador Jr., Mephisto, Dragon Rojo Jr., Rey Bucanero, Euforia, Misterioso and Okumura. It's not stated, but I expect Namajague will be back in NJPW in January and would also be on these shows, in addition to the regular NJPW wrestlers. CMLL is also sending ring announcer Ivan and edecan Bruni.
Mistico and Titan are the tecnicos making the NJPW debut. Euforia is the only rudo making his debut here. NJPW also introduces Rey Bucanero, who's been in NJPW as part of the team with Ultimo Guerrero prior but not in many years (and not under the current regime.) It's a total of 14 CMLL wrestlers this time, up from 9 on previous shows.
The tour is being promoted around the first appearance of the new Mistico. NJPW mentions the previous one was IWGP Junior Heavyweight championship, setting the bar for this one (though I'd imagine that's not something happening this year.)
Titan earned this spot by winning En Busca de Un Idolo, but the 2nd (Euforia), 3rd (Mistico) and 4th (Diamante) place finishers all got in as well. That makes the winning a bit cheap (though true to most reality shows), but I'm not certain Titan would've made it if he didn't make the final 2 of the tournament given where he was before the tournament. This is still a win for #porraTitan.
There is plenty of pressure on the younger guys, but La Mascara might have the most to prove. Mascara was embarrassingly poor on the first FantasticaMania shows, looking in no condition to perform on both shows. It was said Mascara was ill and tried to work thru it (and the wrestlers on the show defended him against criticism), but everything he tried looked abysmally bad. Just having OK matches would be a vast improvement, but the Brazos have a great reputation in Japan and I'm certain La Mascara will be motivated to raise his families name back up.
FantasitcaMania had four title matches in 2011 involving CMLL wrestlers (and one that was between NJPW & DDT), and two in 2012. FantasticaMania expands to three days this year, and so the title match number is likely to increase. Titan (National Welterweight), Rush (CMLL Light Heavyweight), La Mascsara (National Light Heavyweight), Dragon Rojo Jr. (NWA & CMLL Middleweight), Rey Bucanero (NWA Light Heavyweight) all have major CMLL titles. Dragon Rojo's already stated he'll defend against either Jushin Lyger or Prince Devitt on these shows. Lyger makes more sense. Rush being a spotlight match (rematch vs Yujiro? Goto?) seems to fit with CMLL goals, as well as Mascara Dorada getting a big match (Bucanero is not doing much with his belt). Titan vs Euforia would also be a fun showcase for both guys, and it'd be weird if Volador and Sombra weren't involved in something big. There's a lot of possibilities. Unless there's a title change between now and January, there won't be a CMLL pairs or trios title on the line (though Okumura and Namajague are still facing Stuka & Fuego a lot.)
NJPW and CMLL will announce actual matches at a later time, probably early January, and we'll likely know if any of these will be an iPPV around the same time. There will also likely be CMLL participation on the 01/04 NJPW Toyko Dome show. That usually includes 1 or 2 guys who don't end up working these shows.


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New research has revealed that Ireland's December Budget could mean further job losses of 30,000 as 40,000 Irish continue to emigrate every year and unemployment remains at a steady 14.8 percent.
Nevin Economic Research Institute (Neri) researchers claim that the Irish Government will make cuts of $4.5 billion (€3.5 billion) from Ireland's economy in December by cutting key services and income protection for lower earners according to the Press Association.
The government think-tank instead is advising that the Irish Government raise up to $1.2 billion (€1 billion) by increasing taxes on high earners.
Director of this group Tom Healy said Ireland should adopt an alternative budgetary strategy to meet the terms and targets made by the Troika of the European Commission and the International Monetary Fund and the European Central Bank.
He said: "The choice between taxes and spending is ours to make."
"Most people have already taken enough in cuts to public services and wages along with increased charges. What we need instead is a strategy that invests in growth and begins to address the huge shortfall in taxes paid at the very top end of the income distribution."
NERI's latest report states that the Government is failing to introduce the stimulus needed to make jobs and added their cuts could slash 30,000 more jobs.
Currently, the unemployment figures in among Ireland's youth stands at 30 percent, between those aged 18 to 24, according to Eurostat.
Austin Slattery, president of Chartered Accountants Ireland, told FinFacts, "Unemployment continues to grow. After five years of successive tax increases, we cannot afford the damage to the domestic economy any further with more tax hikes in 2013."
Meanwhile, the British publication Emigrate reports that 40,000 people are leaving Ireland annually. Merrion Capital economist Alan McQuaid agreed with analysts who pointed out that emigration is the reason that Ireland's unemployment rates have stayed so comparatively low. Currently, unemployment lies at 14.8 percent.
Also, according to the Quarterly National Household Survey, 6,300 jobs have been created over the past 12 months. Currently, 308,500 people are unemployed in Ireland while only 1,787,900 are in employment.


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A wizard has cast a slow action freezing spell upon a PC. The air gets colder around the PC by one degree a day. If the spell is not broken within a few weeks the PC will freeze and die.
Ideas ( Plots ) | March 17, 2005 |
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The people of war-battered central Homs came Sunday to salvage what remained of their belongings and residences after years of conflict and siege.
Most found little beyond devastated homes, looted businesses and a handful of tokens from better times. They grabbed what they could, stuffing what remained of their former lives into baby strollers, suitcases, or plastic bags and onto bicycles and scooters to take to their new homes, typically temporary residences, often with relatives or in shelters.
"It's not much, just a few small things," said Rafi Sepechian, as he and his wife lugged several chairs, a floral print and a suitcase full of odds and ends from their former flat in the Old City. "It's badly damaged, but we plan to rebuild. We love our home."
The once-bustling heart of Syria's third-largest city is now a jumble of bombed-out buildings, bullet-sprayed storefronts and rubble-strewn streets and alleys. Shelling, aerial bombardment and gun battles have taken an extraordinary toll. Sidewalks are piled high with chunks of masonry, sections of rebar, sundry kinds of trash and other detritus, such as mattresses, computer parts and electrical wires. The smell of smoke is pungent.
A deal finalized last week led to the evacuation of about 2,000 rebel fighters from the historic Old City, allowing residents and shop owners to return for the first time since 2012.
But the Old City and other adjacent former opposition strongholds remain largely uninhabitable. Apart from the damage, there is no running water or electricity. The traffic of former residents collecting their meager belongings clogged the battered streets.
Retaking control of central Homs is a major victory for the Syrian government, which is seeking to project an image of growing stability ahead of the presidential election scheduled for June 3.
Home to more than 2 million people before the war broke out in 2011, Homs has both strategic and symbolic significance. When the uprising began, the city was widely dubbed "the capital of the revolution" against the government of President Bashar Assad. Homs is situated in the heart of Syria, along the routes of major highways south to Damascus, north to Aleppo and west to the Mediterranean coast, a government stronghold.
On Sunday, an almost festive air prevailed here, despite a sense of gloom at the utter scale of the destruction. War-weary residents seemed keen to show their resolve. Many voiced hope that the more than three-year conflict could be winding down, though fighting continues in many parts of Syria, including another rebel-held neighborhood of Homs, Waer, where more than 200,000 people live.
"I think everyone has had enough," said a bus driver known by the nickname Abu Zacarias, who said his home had been destroyed and who was pushing a bicycle that carried blankets and other items from his sister's residence. "We want things to go back [to] where they were before."
Not everyone in this deeply divided city is happy to see the Syrian army back in control. But few are willing to talk about such matters openly, especially to foreign journalists. One 21-year-old student, who like many others declined to give his name for security reasons, did approach a reporter to express his misgivings.
"I wish I could take out my green flag," said the young man, referring to the Syrian rebel banner.
There were no regrets from soldiers such as Abu Jaffa, 25, who said he had been wounded on six occasions by shrapnel and bullets. "I would endure much more to win this battle," said the soldier, who, like several others, preferred to be identified by a nickname.
With the central city now largely under government control, many residents said they thought that car bombings and mortar strikes emanating from rebel-held zones may cease. In recent weeks, the city has suffered a paroxysm of violence, with bombings leaving scores dead.
Christians, who formed a significant part of the Old City population, held a celebratory Mass at the Our Lady of the Belt Syriac Orthodox Church, which was badly damaged but remains standing. The church is known for a venerated relic said to be part of a belt associated with Mary, the mother of Jesus.
At the start of the fighting, clerics removed the relic, precious icons and other valuable items for safekeeping. Looters later dug up the spot below the altar where the relic was kept, priests said, but the item had been safely spirited away by church officials.
"I know there is damage, but this is the happiest moment in my life, to be back in the church where I was baptized and my son was baptized," said Sawsan Hanoon, 40, standing in the debris-filled patio of the church. "We will rebuild it with our own hands."
A few blocks away, mourners came to pay respects at the grave of Father Frans van der Lugt, a 76-year-old Dutch Jesuit assassinated by an unknown masked gunman last month on the grounds of the Jesuit residence. He had refused to leave the district where he had lived for decades even after the rebels took control.
The Jesuit was often seen on his bicycle bringing food, medicines and other aid to the needy in the besieged district. Friends said he disregarded the constant danger in his bid to help residents regardless of their creed. He is buried beneath a tree in the garden of the Old City residence. For many, Sunday was the first opportunity to visit his grave.
The spot where he was shot dead, a few yards away, was marked by a simple plastic chair adorned with plastic flowers.
"We all learned so much from Father Frans," said Mazen Kounnuwaty, 50, an engineer who remained in the Old City until February, losing more than 70 pounds because of the scarcity of food. "He never threatened anyone, only helped people of all sects. Why he was killed we still don't understand."
In the adjacent Khaldiya district, where fighting has destroyed much of what was once a vibrant residential neighborhood, residents were also able for the first time to gain access to their homes and to the area's major landmark — the majestic mosque of Khalid ibn al-Walid. The soaring structure features a pair of minarets and silver domes that once dominated the vista. The mosque's namesake, a companion of the Muslim prophet Muhammad, is considered by many residents as a guardian of Homs.
During the conflict, artillery shells struck several domes of the mosque, leaving gaping holes open to the sky. Inside, bullets have gouged out chunks of the walls and there is fire damage. But the mosque's essential structure remains intact.
"It's very confusing and troubling to see this," said Samar, 25, who is studying to be a teacher. "We in Homs are fed up with war. I wish we could all shake hands and go back to where we were before. But it's not so easy."
As dusk approached, the thud of mortars and the crackle of distant gunfire echoed across the battle-scarred city. Residents accustomed to the sounds of war hardly took notice.


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A community forum for all telemark skiers. A place where telemarkers can get together and share experiences, backcountry and ski area conditions, get free instructional help from professional tele instructors and swap and sell used telemark gear.
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text:
Ecole Cantonale d'art de Lausanne (ECAL) student Thibault Penven has designed a folding boat.
Called Ar Vag, the vessel comprises rigid boards sewn into a waterproof skin so it can be unfolded quickly and stiffened by pushing two folding rods, like tent poles, into pockets in the rim.
A wooden plank inserted through apertures in the walls holds the whole thing under tension and forms a seat.
The project was on show at an exhibition of work from ECAL students called Too Cool for School in Milan last month.


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The birds of Yuma County, Colorado
Lincoln, F.C.
Dec., 1915
Description of a new species of Passerculus sandwichensis savanna from South Carolina
Figgins, J.D.
April, 1918
Description of a new subspecific form of Taxidea taxus from Colorado
Description of a new species of caribou from the region of the Alaska-Yukon boundary
Dec., 1919
Two New Bunomastodonts from Colorado
Cook, H.J.
Feb. 15, 1922
A Pliocene fauna from Yuma County, Colorado, with notes on the closely related Snake Creek Beds, from Nebraska
March 31, 1922
Additional notes on the status of the subspecific races of Branta canadensis
Dec. 15, 1922
Some observations relative to hybrids and intergradation
June 19, 1925
Some observations relative to meteorological Influences
July 20, 1925
"Twice-Told Tales"
Oct. 5, 1925
A preliminary study of early mammals in a new fauna from Colorado
Abel, O. & Cook, H.J.
Nov. 2, 1925
A reply
Figgins, J.R.
Feb. 8, 1926
A new genus of uintatheres from Colorado
Feb. 27, 1926
New Eocene titanotheres from Moffat County, Colorado
Cook. H.J.
March 5, 1926
An item of museum history
April 16, 1926
A new gigantic fossil dog from Colorado
That collection of geese from the San Joaquin Valley, California
Dec. 23, 1926
A new rhinoceros of the genus Teleoceras from Colorado
Feb. 27, 1927
Fossil birds from the Oligocene of Colorado
Wetmore, A.
July 15, 1927
New material for the study of evolution: a series of primitive rhinoceros skulls (Trigonias) from the Lower Oligocene of Colorado
Gregory, W.K. & Cook, H.J.
Feb. 1, 1928
Preliminary descriptions of fossil mammals recently discovered in Oklahoma, Texas and New Mexico, Part 1
Hay, O.P. & Cook, H.J.
Feb. 2, 1928
A new fossil bison from Texas
March 15, 1928
A new longirostrine elephant from Nebraska: Trilophodon phippsi, sp. nov.
May 1, 1928
Note on an interesting juvenile lower jaw of Elephas cf. jeffersoni
May 2, 1928
Proposals relative to certain subspecific groups of Carpodacus mexicanus
April 22, 1930
Fossil vertebrates collected near, or in association with, human artifacts at localities near Colorado, Texas; Frederick, Oklahoma; and Folsom, New Mexico
Oct. 20, 1930
A new Colorado pocket gopher of the genus Thomomys
Miller, F.W.
Dec. 14, 1930
New rhinoceroses from the Pliocene of Colorado and Nebraska
Dec. 15, 1930
An apparently extinct Euglandina from Texas
Cockerell, T.D.A.
Dec. 16, 1930
Two previously undescribed meteorites from Mexico
Nininger, H.H.
March, 1931
Prehistoric flaked points from Colorado and neighboring districts
Renaud, E.B.
March 31, 1931
A proposed standard of viewpoints from which to illustrate horned and antlered mammal skulls
Sept. 26, 1931
An additional discovery of the association of a "Folsom" artifact and fossil mammal remains
New birds from Brazil
Oberholser, H.C.
Nov. 13, 1931
The "Elephas meridionalis" stage arrives in America
Osborn, H.F.
Sept. 7, 1932
Yuma and Folsom artifacts (new material)
Nov. 19, 1932
The grizzly bears of Colorado
Warren, E.H.
Dec. 22, 1932
Two new Colorado mammals
July 22, 1933
A further contribution to the antiquity of man in America
Aug. 1, 1933
The excavation of a meteorite crater near Haviland, Kiowa County, Kansas
Nininger, H.H. & Figgins, J.D.
Nov. 14, 1933
The bison of the western area of the Mississippi Basin
Dec. 5, 1933
The generic status of ? Caenopus premitis
June 23, 1934
Folsom and Yuma artifacts
Dec. 29, 1934
New material for the study of individual variation, from the Lower Oligocene of Colorado
New world man
July 22, 1935
Folsom and Yuma artifacts, part II
Oct. 3, 1935
Directions for the etching and preservation of metallic meteorites
Feb. 1, 1936
Butterflies of Colorado
Cross, F.C.
July 1, 1937
The Colorado Museum of Natural History. An historical sketch
Hanington, C.H.
March 1, 1938
The birds of Cape Prince of Wales, Alaska
Bailey, A.M.
Feb. 1, 1943
A proposed revision of Yuma Point terminology
Wormington, H.M.
Aug. 15, 1948
From Series 2, the Proceedings were published as single numbes, without volume number.
A reappraisal of the Fremont Culture with a summary of the archaeology of the northern periphery [1st part] [2nd part]
May 1, 1955
Archaeological investigations on the Uncompahgre Plateau in West Central Colorado: A diachronic study of Plains-Southwest relations [1st part] [2nd part]
Wormington, H.M. & Lister, R.H.
March 1, 1956
Colorado butterflies, part I
Brown, F.M., Eff, D. & Rotger, B.
Sept. 30, 1954
Colorado butterflies, part II [1st part] [2nd part]
March 21, 1955
Colorado butterflies, part III
Oct. 29, 1955
Colorado butterflies, part IV
April 15, 1956
Colorado butterflies, part V [1st part] [2nd part]
Dec. 28, 1956
Excavations at the LoDaisKa Site in the Denver, Colorado, area [1st part] [2nd part]
Irwin, C. & Irwin, H.
Oct. 1, 1959
Geological significance of a new radiocarbon date from the Lindenmeier Site
Haynes, V. & Agogino, G.
Aug. 15, 1960
Subantarctic Campbell Island [pp.1-30] [pp.31-81] [pp.82-150] [pp.151-201] [pp.202-305]
Bailey, A.M. & Sorensen, J.H.
Feb. 1, 1962
An introduction to archaeology of Alberta, Canada [1st part] [2nd part]
Wormington, H.M. & Forbis, R.
Aug. 15, 1965
Excavations at Magic Mountain: a diachronic study of Plains-Southwest relations [1st part] [2nd part] [3rd part]
Irwin-Williams, C. & Irwin, H.J.
Type material of birds in the Denver Museum of Natural History
Phillips, A.R. & Webb, E.A.
Dec. 1, 1991
Catalogue of the type specimens of fossil vertebrates, Denver Museum of Natural History
Woods, S.C. & Stucky, R.K.
Sept. 1, 1992
A review of the genus Agapema (Lepidoptera: Saturniidae)
Peigler, R.S. & Kendall, R.O.
Oct. 15, 1993
Recent distribution of bison in Colorado west of the Great Plains
Meaney, C.A. & Van Vuren, D.
Dec. 15, 1993
Non-sericultural uses of moth cocoons in diverse cultures
Peigler, R.S.
July 1, 1994
Type specimens of mammals in the Denver Museum of Natural History
Jones, C.A.
A survey of prehistoric disease and trauma in northwest and west Mexico
Pickering, R.B. & Foster, M.S.
Checklist of the Odonata of New Mexico with additions to the Colorado checklist
Evans, M.A.
Jan. 15, 1995
A four-horned specimen of Antilocapra americana
Lewis, G.E.
Dec. 1, 1995
New records of terrestrial mammals in northwestern Colorado
Finley, R.B., Jr. & Bogan, M.A.
The spread of raccoons (Procyon lotor hirtus) into the Colorado Plateau from the northern Great Plains
Finley,R.B., Jr.
Description of seven common fossil leaf species from the Hell Creek Formation (Upper Cretaceous; Upper Maastrichtian), North Dakota, South Dakota, and Montana
Johnson, K.R.
April 1, 1996
Megalesthonyx hopsoni (Mammalia: Tillodontia) from the early Bridgerian (Gardnerbuttean) of the Wind River Formation, northeastern Wind River Basin, Wyoming
Williamson, T.E., Lucas, S.G. & Stucky, R.K.
Dec. 15, 1996
The stratigraphy of Mesozoic and early Cenozoic nonmarine mollusks of Colorado
Hartman, J.H.
April 1, 1998
Life in the Imperial Court of Qing Dynasty China [pp.1-36] [pp.37-65] [pp.66-103] [pp.104-134]
Ho, C. & Jones, C.A. ( eds.)
Nov. 1, 1998
Morphometric variation among some leporids (Mammalia: Lagomorpha) of North America
Ramos, C.N.
July 15, 1999
Fossil flora and stratigraphy of the Florissant Formation, Colorado [pp.1-69] [pp.71-135] [pp.136-216]
Evanoff, E., Gregory-Wodzicki, K.M. & Johnson, K.R. (eds.)
Oct. 1, 2001
The survey and evaluation of abandoned mines for bat roosts in the West: guidelines for natural resource managers
Navo, K.W.
Dec. 1, 2001
Mammals of the James M. John and Lake Dorothey state wildlife areas, Las Animas County, Colorado
May 24, 2002


text:
Bronchiolitis obliterans is a form of chronic graft-versus-host disease (GVHD) that sometimes
develops after stem cell transplantation (SCT) or bone marrow transplantation (BMT).
In bronchiolitis obliterans, immune cells that normally fight infections attack the lungs of
the transplant recipient, causing destruction of lung tissue and fibrosis (scarring). When
fibrosis develops, the lungs cannot work properly.
Montelukast (Singulair) is a drug that has been used for many years to treat asthma. Its use
as a treatment for bronchiolitis obliterans is experimental.
To see if montelukast improves or stabilizes lung function in patients who develop
bronchiolitis obliterans after BMT or SCT.
To assess the safety of montelukast in patients with bronchiolitis obliterans after BMT or
To see if montelukast affects the cells that damage the lungs.
To see if montelukast improves other forms of chronic GVHD, quality of life, and overall
survival in patients with bronchiolitis obliterans after BMT or SCT.
Patients 6 years of age and older with bronchiolitis obliterans following stem cell
Patients take one montelukast tablet daily for 6 months and undergo the following procedures
during this period:
- Lung function tests. The patient breathes into a machine that measures the amount of air
that goes into and out of the lungs. This test is done once a month for 3 months, then
at 6 months, 12 months and 24 months.
- Medical history and physical examination at the study site about every 3 months for the
first year of the study and then at 12 months and 24 months. Patients also have physical
examinations monthly for the first 6 months at their primary doctors office. Tests may
include blood and urine tests, chest computed tomography (CT) scans, echocardiogram
(heart ultrasound), 2- and 6-minute walk tests, and quality-of-life questionnaires.
- Bronchoalveolar lavage in patients 18 years of age and older. The subject s mouth, nose
and airways are numbed with lidocaine. Some patients may need sedation or anesthesia for
the procedure. A tube (bronchoscope) is then passed through the nose into the airway,
and a small amount of fluid is put into the lung. The fluid is then removed and tested
for infections or other lung problems.
- Apheresis to collect white blood cells. Whole blood is collected through a tube inserted
into a vein in the arm. The white cells are extracted in a cell separator machine, and
the rest of the blood is returned to the body through a tube placed in a vein in the
other arm. The cells are used to study GVHD and bronchiolitis obliterans.
- Patients who wish to continue montelukast therapy after 6 months may do so under the
care of their primary doctor, if both agree to the continuation....
Bronchiolitis obliterans (BO) is an insidious disease with high mortality following
allogeneic blood or marrow transplantation (BMT). There are no consistently effective
treatments for BO following BMT and the pathogenesis is largely unknown.
The mechanisms underlying similar immune-mediated lung destructive processes are better
elucidated. Rejection following allogeneic lung transplantation and scleroderma lung disease
result from analogous immunologically mediated destruction of lung tissue leading to similar
pathologic and clinical presentations to post-BMT BO.
Increased leukotriene production has recently been implicated in the development of both
post-lung transplant BO and scleroderma lung disease in animal models and patient studies.
Montelukast (singulair) is an approved, well-tolerated, oral agent that inhibits leukotriene
action in lung inflammation. This agent has been extensively used in children and adults to
treat asthma with an excellent safety profile.
To evaluate if montelukast stabilizes or improves pulmonary function in patients with BO
after BMT using forced expiratory volume 1 (FEV-1) changes as primary endpoints, and oxygen
saturation, pulmonary function test (PFT) parameters (forced expiratory flow (FEF) 25-75,
residual volume (RV) and RV/forced vital capacity (FVC), carbon monoxide diffusing capacity
(DLC02), FEV-1/FVC, FEV-1/slow vital capacity (SVC) ratio), and timed walk tests as secondary
To evaluate the safety of montelukast in the population of patients with BO after BMT.
To investigate if leukotriene elevation contributes to the pathogenesis of BO after BMT by
measuring leukotriene levels of the blood, urine, and bronchoalveolar lavage (BAL), and
leukotriene surface receptor expression on immune cells before and after montelukast
To determine if montelukast improves other chronic graft versus host disease (cGVHD)
manifestations, quality of life, and overall survival.
Patients greater than or equal to 6 years old with bronchiolitis obliterans following stem
cell transplantation for any disease indication may be enrolled.
This is a prospective phase II study, the primary aim of which is to assess whether
montelukast improves or stabilizes the pulmonary function of patients with BO after BMT.
Primary outcome data will be analyzed in 2 ways. 1) The proportion of patients with stable or
improved percent predicted of FEV-1 will be compared against benchmark data obtained from a
literature review. 2) The slope of FEV-1 before and after the introduction of montelukast
will be compared.
Pediatric and adult patients with BO following BMT will receive approved doses of montelukast
The planned length of the study would be 2 years per patient with primary endpoint at 6
months, permitting sufficient time to determine safety and meet other endpoints.
This phase II trial will be conducted at 2 institutions: National Institutes of Health (NIH)
and Fred Hutchinson Cancer Research Center. Forty-five patients will be enrolled on this
Age greater than 6 years old.
Diagnosis of bronchiolitis obliterans after allogeneic or autologous stem cell transplant.
The criteria will be based on the definitions created by the National Institutes of Health
(NIH) consortium on chronic graft versus host disease (cGVHD). As part of these criterion,
for patients without pathologic evidence of BO, one other sign of chronic GVHD must be
present. For diagnosis of cGVHD, a minimum of the following must be present: 1) a process
distinct from that diagnosed as acute GVHD, 2) the presence of a diagnostic sign or a
distinctive sign supported by another clinical or laboratory test, and 3) the exclusion of
other pathologies (i.e. recurrent cancer, drug reaction or infection (see Appendix 5a for a
list of diagnostic signs.). To meet criteria for a diagnosis of bronchiolitis obliterans,
patients must fulfill all 3 criteria. Prior lung tissue biopsy will be analyzed and
confirmed to show evidence of bronchiolitis obliterans by the National Cancer Institute
(NCI) Laboratory of Pathology if available. If tissue is not available for confirmation, a
new biopsy will not be performed.
For bronchiolitis obliterans:
1. Forced expiratory volume 1 (FEV1) less than or equal to 75 percent of predicted by
pulmonary function evaluation for height and weight.
2. Evidence of air-trapping or small airway thickening or bronchiectasis on high
resolution chest computed tomography (CT) and residual volume (RV) or RV/forced vital
capacity (FVC) greater than 120 percent and evidence of chronic GVHD of another organ,
OR FEV1/ vital capacity (slow or forced VC whichever is larger) ratio less than 5
percent of predicted for age or less than 0.7, OR pathologic evidence of bronchiolar
inflammation and obstruction of the lumen consistent with a diagnosis of BO. Pulmonary
function tests will utilize body plethysmography not helium studies for pertinent
values when there is a discrepancy if available.
3. Absence of active infection with appropriate investigation of any clinical symptoms to
include radiographic, microbiologic, and pathologic studies as determined by the PI or
Patients must also have 2 PFT measurements with documented FEV1 values greater than 3
months apart to calculate the entry FEV1 slope. All available prior PFTs will be
utilized for baseline slope calculation. For adult patients, the absolute FEV1 will be
utilized for slope calculation; for pediatric patients, the percent predicted will be
used. For patients enrolled after an acute decline following BMT without 2 post-BMT
values greater than 3 months apart, the pre-BMT value may be utilized as the first
value and the entry PFT value may be the second for the slope calculation. The
baseline and 6th-cycle PFT should be done at the accruing site.
Prior therapy: For patients with a chronic diagnosis of BO who have been on
treatments, any prior therapy that has been administered chronically for > 3 months
will be acceptable for enrollment as long as the patient has not demonstrated
consistent improvement attributed to these agents in a one month (or more) period of
observation preceding enrollment. For patients on steroids, a steroid burst exceeding
and increase of one half mg/kg/day will be considered for the start of the 3 month
monitoring period. Notably, documented intercurrent infections that are treated with
antimicrobials that result in improvements to, but not above previous baselines will
not be considered an improvement attributable to immunosuppressive therapy. Patients
who have had consistent improvements in the months preceding trial entry will not be
eligible since there will be no way to discern improvement due to montelukast versus
another therapy. Alternatively, a patient with a new diagnosis of bronchiolitis
obliterans characterized by a new decrease in FEV1 is also eligible for this study.
Notably, patients who have received bronchodilators or other pulmonary therapies may
be included in this study as long as montelukast is not part of this regimen.
Performance status: Karnofsky or Lansky performance status greater than or equal to 40
percent (Appendix 1).
Ability to give informed consent. For patients less than 18 years of age, their legal
guardian must give informed consent. Pediatric patients will be included in an age
appropriate discussion in accordance with NIH guidelines or participating
institutional guidelines.
Hepatic function: Patients must have evidence of adequate liver function prior to
enrollment defined by total bilirubin less than 3 times the upper limit of normal and
transaminases less than 5 times the upper limit of normal for age appropriate indices.
Cardiac function: Patients must have evidence of adequate cardiac function prior to
enrollment defined by ejection fraction greater than 25 percent performed within the
last 6 months at NIH and absence of symptoms of cardiac disease at FHCRC, JHH, or
Pulmonary function: Patients must have an FEV1 greater than or equal to 20 percent
predicted for inclusion in this study.
Underlying disease status: Patients with tumor burden greater than minimal residual
disease (i.e. tumor burden that can only be detected by molecular methods) would be
excluded from this study.
Prior post-transplant treatment with montelukast or zakirlukast within the past 2
months and total duration of therapy does not exceed 3 months.
Clinically significant systemic illness with manifestations of significant organ
dysfunction which in the judgment of Principal or Associate Investigator would render
the patient unlikely to tolerate the protocol therapy or complete the study.
Patients must have been on their current cGVHD therapeutic regimen for at least 3
months with stable or decreasing FEV1 to be eligible for this trial. Any patient who
has been on a therapy for less than 3 months for cGVHD will need to be monitored for 3
months without improvement in FEV1 prior to enrollment.
Ventilated patients are excluded.
Patients taking rifampin or phenobarbital as these medications alter the metabolism of
Patients taking greater than one age-appropriate dose of ibuprofen or aspirin
containing products per day that inhibit cyclooxygenase will be excluded from this
trial. The acceptable upper limit for adult daily doses of aspirin is 650mg/day and
800mg/day of ibuprophen. For children, the acceptable upper limit of ibuprophen is
pediatric dose per day (less than 10 mg per kg to a maximum of 800 mg). Children
should not take aspirin due to risk of Reye's syndrome unless specifically prescribed
by their physician.
Patients with a history of allergy to montelukast.
Pregnant females and nursing mothers will be excluded from this trial due to unknown
risks to the developing fetus. While on study, patients of child-bearing potential
must be able to consent to utilize effective birth control measures.
Principal InvestigatorRonald E Gress, M.D.National Cancer Institute (NCI)
Bethesda, Maryland 20892United StatesThere is no listed contact information for this specific location.Site Status: N/A
| All trademarks are property of their legal owners. | All Rights Reserved
ClinicalConnection.com is a resource that provides information on clinical trials conducted worldwide.
ClinicalConnection.com does not conduct or endorse clinical trials. Please consult your physician before participating.
© All Rights Reserved.
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text:
The most sophisticated natural products made with love in New Zealand and delivered direct to you.
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Hi Kim, Kimbra here!K x
Just wanted to write a quick note to say thank you for the lovely Vision products! Very kind of you and I wanted to just encourage you in the work you're doing as it has been really nice to read about the backstory, ethics and 'vision' (so to speak!) behind your company and what you stand for. I appreciate you taking the time to share that with me, keep up the great work!
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text:
Man, how many months has it been? There's so much I've missed– dead celebrities, offensive legislation, fried chicken debates. You lose track of things once you start getting laid regularly.
Also! The atheist/skeptic/whatever movement blew up. Everybody got so sick of bullying dudebro skeptics, who were so clever when they found out the truth about God but didn't think to apply that skepticism to gender roles or social issues, that we had a wee schism. C/O Jen McCreight of Blag Hag, we have leveled up to become Atheists Plus!
"Keep unintentionally or intentionally excluding women, minorities, and progressives while cluelessly wondering why you're losing members, money, and clout. The rest of us will be moving on.
If you're ready for this new wave of atheism, now is the time to speak up. Say that you're ready. Vocally support organizations and individuals that are already doing it right. Vocally criticize the inappropriate and hateful behavior so the victims of such actions know you're on their side. Demand that your organizations and clubs evolve, or start your own if they refuse.
The Boy's Club may have historically ruled the movement, but they don't own it. We can."
I'm up for it. I am now an atheist plus. Or a plus atheist. Wev.
And to celebrate, I made a new t-shirt.
Sexist Skeptics Eff Off Shirt by JohnnyKaje
Browse Zazzle for another teezazzle.com
Hopefully I can get my shit together and get a booth set up at Skepticon. But if I don't, you can still get your shirts now! Wear it the next time you're inexplicably booked for TAM! and can't find someone else to go in your stead.


text:
If the radius of the circle is equal to the length of the chord $AB$, what is the value of $x$?
How would I solve this problem ?
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If the radius of the circle is equal to the length of the chord $AB$, what is the value of $x$?
How would I solve this problem ?
Let $O$, be the center of the circle. In $\triangle OAB$, $AB=OA=OB=$ radius implying $\triangle OAB$ to be an equilateral triangle. Thus, $\angle OAC = 10^\circ$.
Again, in $\triangle OAC$, $OA=OC$, so it is an isosceles triangle, thus $\angle OAC= \angle OCA=10^\circ$
Now, using the central angle theorem, $\angle COB = 2\times \angle BAC= 100 ^\circ$
$\triangle OBC$ is also isosceles (as $OB=OC$), thus $\angle OBC= \angle OCB=\frac 12 (180^\circ-\angle COB)=40^\circ$.
Now, $\angle OCB = 10^\circ + \angle ACB\implies \angle ACB = x = 30^\circ$
The sines theorem: using your drawing: $$\frac{AB}{\sin x}=2r\,\,,\,r=\,\text{radius of the circumcircle}\Longrightarrow \frac{\rlap{/}r}{\sin x}=2\rlap{/}r\Longrightarrow$$ $$\Longrightarrow \sin x=\frac{1}{2}\Longrightarrow x=30^\circ$$
I got the answer , by constructing an equilateral triangle from the origin.Thus making angle of the Arc 60 degrees.Now since angle is 60 degrees so the inscribed angle must be 60/2 –


text:
Easy Email Encryption Lite Lives up to Its Name
Today's Best Tech Deals
Picked by PCWorld's Editors
Top Deals On Great Products
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If you're looking for a very simple way to protect the privacy of your e-mail communications, look no further than Easy Email Encryption Lite ($18, demo). It provides about an easy a way to encrypt communications as you'll be able to find--as long as the receiver has a copy of the program as well.
To encrypt a message that you want to send, copy it into the program, tell the program to do the encryption, and it copies the garbled, encrypted text to your clipboard. Simply copy the encrypted text into an email message and send it along. The recipient can then copy the encrypted text to their Windows clipboard, and have Easy Email Encryption Lite decrypt it. That requires, though, that both sender and recipient agree on the key to use.
You can use keys of between 16 and 64 characters, and the longer the key, the more secure will be the communications. The software uses an encryption method called Cryptosystem ME6, which was created by the Easy Email Encryption Lite's developer, Hermetic Systems.
The downside to Easy Email Encryption Lite is that both user and sender need to use the same software. By way of contrast, an encryption standard such as OpenPGP allows people to use different software, but the same standard.
If there are one or two people with whom you often share e-mails that you want to keep private, Easy Email Encryption Lite is a simple solution. It's not overly technical, and makes it easy for anyone to encrypt communications. And if you have valuable information that you need to keep private, $18 isn't too high a price to pay.


text:
Ingredients: Coconut Oil, Distilled Water, Glycerin, Orange Essential Oil
20% of each sale is donated to the Florida Abolitionist non profit organization. Vitazon is focused on helping to end human trafficking in the state of Florida, especially in our local Orlando Community.
is backordered. We will ship it separately in 10 to 15 days.


text: One of our favourite concepts from 2005, the impossibly futuristic Pivo has been kept under close guard by Nissan, until now. They still won't let anyone drive the car - distinguished by a cabin that rotates 180 degrees - or allow it out for photo shoots, or reveal details of how it works, but they did let an Aussie TV show film the car while an engineer drove it. Hot rotating cabin action inside.