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To me there are two words that best describe Wednesday night's 30th District Tournament girls' basketball semifinal between Collins and Shelby County - instant classic.
There's no other way to describe the Titans' 52-48 double-overtime victory over the Rockets at Collins. If Shelby County had its own version of ESPN Classic the game would've already been aired five or six times.
"It was a great game," Titans Coach Phillip Conder said. "It was a great game to be a part of, I'm sure the fans enjoyed it."
It featured a sensational performance by Collins senior standout forward Aaliyah Wells (36 points, 11 rebounds, 6 steals), last-second shots, last-second free throws, several lead changes and plenty of drama.
Wells hit a buzzer-beating 3-pointer at the end of the first quarter and a last-second jumper at the conclusion of the second period. She then scored the first basket of the third quarter to push the Titans' lead to 10 points. In that type of slow-tempo game that advantage was probably more like a 16- or 18-point cushion, but the Rockets never folded.
Sophomore point guard Katie Hudgens started Shelby County's comeback with a layup and a 3-pointer to quick cut Collins' lead in half. The Rockets eventually tied the game in the fourth quarter, however, on Savannah Raizor's game-knotting 3-pointer Hudgens fell hard on the floor.
She was taken off the floor on a stretcher with a left hip injury (thankfully all x-rays afterward were negative), but didn't return. [Side note: The Collins players & coaching staff sent Hudgens some flowers after the game]
It was a tough blow for Shelby considering that Hudgens is the team's best ball-handler, but the Rockets didn't back down. If anything it seemed to energize them. They took the lead and still had it in the final seconds. At that point I already had the first sentence for my story in Friday's paper figured out – This one was for Katie – it would have read.
Instead Wells would hit two free throws with no time on the clock to send the game into overtime. She was the only one on her side of halfcourt when she shot the free throws (no pressure, right?!). Now afterward there was debate as to whether the final whistle of regulation should've been a block or a charge, and if that whistle itself even came before the clock hit zero. I still haven't seen a replay of that last call and I can't even give an opinion because I was on the opposite end of the court and was looking through my camera lens at the time.
"I won't say anything about the calls, I'll let other people pass judgment," Shelby County Coach Mike Sowers said afterward.
For my part I'll say this. Yes there were some debatable calls, but you have those in every game. My guess is that those will only add to the lore of this game when people remember it years from now.
"They did everything to win the game and I thought both teams did," Conder said. "That's one of those games you hate to see any team lose. They played their hearts out and we played our hearts out."
To me those are the signs of an instant classic.
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Just because SoCal's chances of a White Christmas are disappointingly low, doesn't mean L.A. residents skimp on the tinsel and trimmings. If anything, it's added incentive to be ultra-festive when the holidays roll around. And, one quick drive around Lala ("quick" being relative to your proximity to the 405) and it's plain to see that the local store owners take their window displays just as seriously as they do their wares.
But, before you drop some serious bones on a full tank, why not save the dough and take a virtual winter wonderland tour of our sunny city? Sure, there's not a flurry in sight, but that shouldn't stop you from sipping hot cocoa as you click through these snaps. Just try not to spill as you scroll — these stunning snaps are that dazzling!

subset: commoncrawl


text: I've recently converted a Live 07 1991-92 roster patch by Tony Divence over to 06 with lots of help from Jao and Andrew. All the FSS moves work properly after some adjusting of the dunk packs. I'm sorry I haven't included the art but everytime I tried uploading it somewhere it wouldn't work. I'll try again later but all the art needed is in a patch called HisRostersDVCv2 which I got here. The court and logo art don't work anyway but the jerseys and faces do.


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Lambert hopes Villa handle pressure
Aston Villa boss Paul Lambert knows the buck stops with him as he tries to see out a difficult season by at least preserving the club's Barclays Premier League status in a "cup final" against Hull on Saturday.
The Scot is well aware his struggling side can effectively secure their place in the top flight by improving their woeful home record against the Tigers at Villa Park.
With two matches remaining away to Manchester City and Tottenham after Hull's visit this weekend, the pressure is on Villa to do the business against Steve Bruce's side.
And while Hull have an actual FA Cup final on their minds, Lambert admits this league scrap is one of the most important matches in his players' careers.
"If we win then it virtually gets us out of the relegation battle," he said.
"That's how big the game is. Everybody knows it. I said the other day that this is like a cup final and we're at home, with the backing of 38,000 people. That will have to drive us on as well and if the lads perform against a good side who have had a really good season then we'll do it.
"The ironic thing is that if we win, we can go above Hull."
Experienced striker Gabriel Agbonlahor labelled the match one of the biggest of the players' lives and Lambert can appreciate his forward's sentiment.
"It's pressure and you deal with it," he said.
"Gabby is saying that because they're still young. When they're 29, 30 years of age, hopefully if their careers keep going they'll have massive games to play in.
"I understand what Gabby is saying about it being a cup final, and that is how we have to treat it. You have to give it everything you've got and if you win then it puts everything out of the road."
Lambert and his players bore the fans' frustrations after last week's 4-1 loss at Swansea but the manager hopes they can put those emotions to one side for the good of the team.
"The fans will be there, they'll come in their thousands to watch us and they will get behind us," he said.
"That's important because the lads will need that backing from them. I've no doubt that's what they'll do."
Hull manager Steve Bruce would happily shake hands on a dour goalless draw if it meant ensuring Premier League football next season.
The Tigers already seem safe, with a five-point buffer and a game in hand on the bottom three, but that assumption could become a mathematical fact if results fall favourably over the weekend.
A draw at Villa Park would take Hull to 38 points - a mark that is virtually certain to guarantee safety this season.
Bruce would accept a repeat of the sides' tepid encounter at the KC Stadium in October as a means to an end.
"A dull 0-0 will do me on Saturday," he said.
"Last time against Villa was an awful affair. Me and (Villa boss) Paul Lambert both said it was arguably the worst game we'd seen in a long time. This one must be better because it couldn't be much worse.
"Yes, we are in the entertainment business, but the main aim for us is to stay here in this division and it looks like we're nearly there, which was the biggest challenge to us all when we came up."
Bruce also believes Lambert, whose side have taken only one point from their last six games, would be able to rest easy with a share of the spoils.
Having long predicted a final-day finish to the relegation scrap, Bruce now believes the picture is starting to clear, with Cardiff, Norwich and Fulham having just two games to lift themselves clear.
"It's very, very difficult for the bottom teams to get to 36 now. It looks from afar like the bottom three have got it all to do, they have to win," he said.
With an FA Cup final on the horizon and a Europa League place a done deal if their final opponents Arsenal stay in the top for, the future looks bright for Hull.
Bruce has been the driving force behind their return to prominence and reports have emerged that the club's owner Assem Allam is looking to turn his 12-month rolling deal into something more permanent.
Bruce would not elaborate too much on that score but said: "The owner is delighted, like we all are.
"I go and see the owner once every two or three weeks for a cup of coffee and I'm due again next week probably.
"It'll be terrific to talk about next year now and start putting plans in place.
"We'll sit down, see where we are and plan ahead."
Source: PA


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Anyplace in my city, there are asphalt and concrete. It's hot in the spring.
We see weeds and flowers in crevice of the pavement or stone wall. How strong they are!
May 29, 2007
Concrete flowers
Anyplace in my city, there are asphalt and concrete. It's hot in the spring.
May 24, 2007
May 23, 2007
May 22, 2007
Tissue case
Maybe you have mini tissue in your handbag.
It is called pocket tissue in my country.
Why not make covering case?
It is easy.
Cut cloth and sew frill. Fold from both side and sew.
Red one is made of Japanese chirimen paper.
May 18, 2007
Diet cookie
Today I made diet cookies of okara.
Okara is dregs of tofu. You can buy okara at a tofu store.
Okara 150 grams. (1 gram is 15.4 grain.)
Onion 150 g.
Brown sugar 15 g. Skim milk 10 g. An egg.
Agar powder 3 g if you have.
Spices you like.
Microwave small chopped onion and sugar.
Mix all materials and some water. Divide it 15 pieces.
Bake them in an oven.
15 cookies have 400 kilocalories.
If you eat only 5 cookies and water at supper, you will be slim. Maybe.
May 17, 2007
I don't like insects.
But I'm very fond of pictures and reading about insects.
I have a lot of books about insect.
Recently I read the book about mystery of seventeen-year locust.
It's full of mathematical interest.
A big "seven spot ladybird beetle" of felt. One inch.
The antennas and the legs are threads.
May 16, 2007
Bunka doll
This is my first Bunka doll. 58 cm tall.
Bunka doll has an orthodox method of making. But I don't know it.
So I made it in my original way. This is a fake Bunka.
Bunka doll is a sort of Japanese doll.
Not so traditional.
I heard that Bunka dolls are very popular in 1920 - 1960.
'Bunka' means 'culture'. I don't know the origin of the name.
In that time, people must have admired foreign dolls and wanted to make European dolls by their own.
Bunka dolls are never clad in kimono. Every doll puts on bonnet and one-piece dress.
Funny face is like Betty Boop, isn't it?
Now Bunka doll is also loved as retrospective item.
Maybe you think they are cute.


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Well...had no clue about this tagging business about an hour ago when I had this sudden scrap from Kriti -"Uve bin tagged ",and i was at a loss to understand what exactly she meant by it... But after a li'l explaining and a sample too ,i can say i'm well versed with this tagging thing ,coz i've already done a lotta similar stuff filling slams and profiles on social networking sites!!!
Though I really hate that i'm sitting here and typing when i would have otherwise bin sleepin...lol... but newaz now that the responsibility has bin thrust upon my frail shoulders (or better put it as fingers..lol),i'd better play my part and complete this thing that i've started with !! ;)
And as far as the readers of this space are concerned ,i'm not exactly putting in extra efforts to make your day or to earn brownie points from your side ,I'm doin this just coz therez somebody out there who wants to know my opinion (which by the way ,might waver and sound quite confusing especially since i'm in this inebriated post thomso depression phase !!!)
.So if you take my opinion (ohh dat dilly-dallying again) ,you better spend your time doing something productive ,coz as far as i know you may very well be appalled by my honesty ...but thats the way I am...I wont live my life as dictated by the norms ,and so my answers might sound a li'l cliched ...
Newaz,not to keep you hanging in here(and if u have come till here ,you must surely be interested !!)...here it goez
1. Pick out a scar you have, and explain how you got it.
I aint no harry potter ,so i dont have a sensational tale to tell of wizards and what not....
Umm...i have these 2 scars on my forehead(a la HARRY yes!!)... dont exactly remember what happened and it might sound really weird ,but as far as i remember i was cycling at the age of about 12 ,when i saw a parrot ,and i stopped in my tracks and started staring ...it suddenly started to fly and it went flyin over my head ,and in a bid to catch a close -up ,i twisted my neck a li'l more than 180 degrees ,and in the resulting torque ,I along with the cycle ,somehow lost balance ,the front wheel of the cycle was suddenly in the air ,and the next thing i know was that i was in the exact reverse position to where i had been earlier...the cycle was now on top of me (maybe it also wanted to catch the parrot!!) ,and my head was bleeding profusely....lol
2. What does your phone look like?
Well it looks really hot and sexy and ....
oh hell, what kinda question is this !!! Its a Nokia 3230 and ofcourse looks like any other 3230!!!
To elaborate more ,i'd say its the red version ,and its so old now that its lost all its sheen ...lol...
3. What is on the walls of your bedroom?
Umm....posters and more posters....I'll give you a list:
- One poster with a red background ,two teddies and with the message -"LOVE -I cant put it together without you"
-Three posters of Thomso (one for every year)
-A small poster of Kareena Kapoor...nahh she aint my fav actress ...but i found this really hot poster in a filmfare magazine and so ripped it and put it up
-Academic calendar for the current year....(its important to know the holidays right!!!)
Well, thats about it ,apart frm the wall paint ofcourse!!
4. What is your current desktop picture?
Uhh...bad timing...a Riya Sen wallpaper (i aint no pervert ok...just keep changin em randomly!!)
5. Do you believe in gay marriage?
Who am i to beleive !!! Leave alone gay marriages ,i strongly am against the institution of marriage altogether , so this question automatically becomes redundant for me...
6. What do you want more than anything right now?
Well...a very good internship ,a seat in a 'good' IIM, and uh ,someone to take care of me ,coz i'm really spoiling myself ,and losing my mind to nonsense (and my liver to alcohol)...Damn i hate being alone when there are so many people around...
7. Are your parents still together?
HAHAHA!!!! Ye to bhagwaan ko bhi nahi pata!!!!
8. Last person who made you cry?
Many... and it alwaz has to be the one who i care about the most!!!
9. What is your favorite perfume/cologne?
Have no real favourite ...but i generally like (and use) BRUT or AXE ,and yeah my best possesion was an ADIDAS spray
10. What are you listening to?
Nothing at the moment ...but if this means my favourite music ,i'll definitely say it has to be something that has a meaning ,and something that doesnt hurt ur eardrum...No heavy metal rock for me puhleez
11. Do you get scared of the dark?
Used to when i was a li'l boy...but not anymore ...usually m so tired by the time it gets dark that when i close the lights ,therez nothing on my mind except a sound sleep!!!
12. Do you like pain killers?
Argghhhh....whats wid liking a medicine!!! Will have to use it when therez a need ,otherwise i dont think anybody "LIKES" meds!!!
13. Are you too shy to ask someone out?
Not if its some1 i dont know (have a lotta experience asking out girls at the fest ) ,but otherwise ,yes ,veryyy scared ....I might as well say I'll never do it :P
14. If you could eat anything right now, what would it be?
A Brownie with ice cream (any!!!) or probably pasta/spaghetti in cheese sauce!!!mmmm.....
15. Who was the last person who made you mad?
A stupid IITian ( i mean a fellow batchmate)who interfered when we were trying to make a Bakra of a guy we caught during our fest... Spoiled everybody's mood...
16. Who was the last person who made you smile?
Yeah got it...it has to be DS,coz she got a really gr8 job !!!!
17. Is someone in love with you?
HAA!!!!! That so not possible.... whoz this frickin idiot who put this question here...
Well...had no clue about this tagging business about an hour ago when I had this sudden scrap from Kriti -"Uve bin tagged ",and i was at a loss to understand what exactly she meant by it... But after a li'l explaining and a sample too ,i can say i'm well versed with this tagging thing ,coz i've already done a lotta similar stuff filling slams and profiles on social networking sites!!!
Posted by Aupsy-The cOOlest One!! at 1:08 PM 7 comments
Labels: Miscellaneous
Brought to you in association with Red FM...lol....
Ok...so here we are ...was in delhi for the weekend ,for dussera to be specific ,and was completely hooked on to this new initiative by red FM to make delhi a NEW delhi,by bringing to the fore all that which hasnt been inconspicous but had been conveneiently taken for granted by the junta . I liked it because it brings an issue which ,if it stays the way it is ,will never let delhi acheive the world class city status it is vying for.
So i though why not present to you the very people who enrich delhi's society in a very different way ,and who've helped the people to stand up and take notice of even their daily routines .They are very normal people to come across ,and therez nothin wrong about their presence until they unleash their powerful weapons of mass destruction!!These personalities are famous PAGE 3 honkies in a world of their own,and so deserve specail applause!!
What i'm stating here is not essentially a repeat of what is already being broadcast ,but obviously my own version of it ,though you mite find some characters outta the original thing too. Ok,so here it goes :
- Puri dilli pe hai inki chhap....inki vajeh se mehekti hai dilli ki har galli ,har sadak....par ye nahi koi sadakchhap....ye hain....SUSU UNCLE...
"Thank you thank you.... bhai finding a clean non-urinated corner in delhi isnt a child's play ...i work so hard everyday ,and when i set out from home i have just this one objective in mind !! Its only because of me that so many people employed in the civic agencies get a good pay and can earn their daily bread!! Its because of me that there are still some corners in delhi which have negligible population density!! And its because of me that people dont have to care about putting on a DEO while moving out ,coz my fragrance is all around .It is only obvious that I am the first choice for the honours ...it encourages me to work harder (!!!) and take out more litres everyday...who knows the delhi jal board might need me one day " :P
- Ye jahaan jaate hain logo ki nazren inke saamne jhuk jhaati hai ....ye woh hain jinki wajeh se hua salmaan khaan ka har hairstyle kaamyab...ye hain ....CHHEDKHAANI /EVETEASER UNCLE....
"Thank you people... and i dont think i should be giving you any reasons as to why i am here ....Blimey! Isnt it because of me that no girl in delhi feels neglected...its only me who can scan them frm bottom to top ,and flatter them with my sweet whistle...Havent you wondered why the girls are always well-dressedd...ahh...make no mistake ,had i not encouraged them to do so ,they'd still be so bland!!! And what the heck,even the cops are by my side....yeah,they might catch a couple doting over each other at the neighbourhood park ...haha....but me,i'm always spared the honours ....With this award i promise to take voyerism in delhi to new heights...watch out for me people ,esp girls ,i'll alwaz be there for ya!!!!!!!Muahahah!!!"
- Now this onez a pure nature lover ...ye jo kaam karti hain janhit mein karti hain ...stray dogs and cows ka special dhyaan rakhne waali....ye hain ..... KACHRA AUNTY...
" imagine kya hota agar main na hoti toh....ur garbage would've been spilling over and u'd be sleeping on a pile of banana peels.... its only me who avoids all the ruckus at your house and dumps all the kachra behind ur society wall...so that you can sleep in peace...ab kya farak padta hai if it gives out a smell ,atleast u wont have to buy room fresheners and artificial sources... be natural ,thats my funda....and who else would care about all those hungry dogs and cows !!! Kabhi socha hai unke baare mein...woh bhi to insaan (!!!) hain ...and imagine who'd come and ask for and share your burden of sweets that you recieve on diwali ....atleast because of me ,all the health conscious people can relax about not being forced to take in everythin.... From this year onwards ,i promise to dicharge my duties dilligently ...hope u'd love the new smells and aromas ,coz i plan to do some useful experimentation with the kuda!!!!!!!
- Inke haaton mein hai jaan....dilli ki jaan....dilli ki sadko ke baadshah....yeh hain....BLUELINE DRIVER UNCLE...
"i have the capabilty to bring delhi's life to a standstill,and more than that ,i'm best at taking some1's life....terrorists,gangsters ,criminals,encounter specialists are oh so passe ,i am the new kid on the block...be it a li'l child goin to school ,or a hardworkin man returning home after earning the day's bread ,or just a poor chap hobnobbing on the road for no reason at all,i dont spare anybody ...and what's more...i dont even take money !!haha...i kill for free...so come all ye wretched souls gimme ur hands,legs and everythin else,and i'll squash you under my bus !!"
- Ye hain dilli ki sundarta ka raaz.... dilli ko bahut hi jaldi red city banane ke liye hain ye nikle ....ye hain...PUKE UNCLE ..."are bhai ab tambaaku khaynge to thunkenge bhi na...and after all this is our art... hum bhi M.F.Hussain se kam nahi...and we dont even waste colours and dont even need a canvas....the whole city is our canvas ,and we have just one aim in mind -to puke more creatively and innovatively ... aap nai samjhoge...but the people who appreciate arts definitely will....agreed that an ordinary man may find it annoying ,but when accolades from all over d world start pouring in,he'd come back to me to congratulate me... and hey,we have full support frm the Tobacco companies n roadside paanwaalas... "
Posted by Aupsy-The cOOlest One!! at 10:25 AM 7 comments
At the LIBRARY...
STATUARY WARNING:This post has no resemblence to any person living /dead. Any such case,henceforth ,should be deemed as purely unintentional and coincidental. And oh,any1 who thinks he/she has been in the same spot at any point of time in their lives are invited to comment .Any living person who finds it objectionable beyond his/her temper is cursed to rot in hell!!!
Hey there looking at me
Temme what do u see
Behind the glasses that disguise
and that ridiculous smile and li'l eyes
But hell ,you quickly turn your head away
I try to fight with words
Dont have the courage to come up to you
My chances are looking a bit grey
Digging your head in that dusty book
Are you trying to evade my look??
But aint nobody tell you honey
life is just a tad more funny
Which year may I ask
or which course may I prod
What difference would it make
I'll make do with an approving nod
Ohh but how did i forget
Aint u that rarest of species at this place
with all that air on your face
and a nose thats always held up high??
Am i not supposed to stay away
from the queen of the world
err....rather the queen of your world
for thats what they say
But i come back to reality
and once again captivated by your beauty
Staring across the room
Are you leaving soon??
But hey ...I ...I just need a li'l time!!
Why did you have to leave so soon?
Why did you have to walk away?
Oh well it happened again
She walked away with her "boyfriend"
Maybe we'll meet again someday.
Posted by Aupsy-The cOOlest One!! at 11:37 PM 14 comments
Labels: Life...or sumthin like it


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Change Default Text Editor In BackTrack Linux To vi
Changing the default text editor to vi on Ubuntu is fairly easy however it may be tricky depending on how it has been set since there are numerous ways. In BackTrack Linux for instance the default editor is set using select-editor so if you follow another Ubuntu Linux howto it may tell you to modify the default editor using update-alternatives. Below I describe setting the default text editor using both of the mentioned methods and note a couple other locations where it can be set.


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LAW7919 - Clinic: United State's Attorney's Externship
Course Number:
Students will assist in the investigation and litigation of civil rights cases in the U.S. Attorney's Office for the District of Connecticut. The year long clinic will include classroom seminars and field assignment. In the once-a-week classroom seminar, students will receive instruction on topics including: official misconduct; educational access; human trafficking; hate crimes; housing and lending; language access; religious land protection; rights of the disabled; rights of institutionalized persons; rights of service members and veterans; and voting rights. Classroom instruction also will include segments on statutory interpretation and federal investigation techniques and procedure. In field work, students will work under the supervision of Assistant United States Attorneys, investigators, and paralegals on investigation tactics, evidence gathering, pleading drafting, deposition preparation, document review, legal research, litigation strategy, and settlement negotiations in each of the pending civil rights matters to which they are assigned. Students may enroll for the second semester of this course only with the permission of the instructor. 3 graded credits each semester.


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Public Service, Regulatory, Services
By By Lee Benson | September 1, 2011
Send Feedback
In my last article ("Tips for Younger Pilots," July 2011 Rotor & Wing), I expressed some thoughts for folks contemplating a career as a helicopter pilot. I've received a lot of good feedback on this article and would like to expand a bit and focus on things to think about from a career standpoint.
First of all, I would like to say that I've never worked for a bad helicopter company. I define a bad company as one that thought more about their bottom line than my bottom. Yes, I've worked for companies that didn't pay as well as I wished they would have, but I never felt that my safety was compromised. This happened in my career because it was my first goal to work for companies with a good safety record. I had opportunities to work for more money on occasion, but stayed true to my first goal. I am alive today, so I guess it worked.
I'm not gifted with the ability to make anyone my friend, that was my dad; I am not the funniest person in the industry either—that would be Stu Taft. This is a very small industry. Not everyone you'll work with will be a good match, but try to stay cordial, be professional, keep the rumors and back stabbing to a minimum.
I guarantee you that any enemies you make in this business will be in a position to hire, help or hinder you down the road. If you have kept the interaction civil and professional, the least you can expect is that if your name comes up, this person's input will be at least neutral.
Maybe this is more true in the past than now, but helicopter work is seasonal. Don't be the pilot that lets the company carry him through the slow time and then when work picks up, take a different job for another bit of money per month.
Loyalty is a two-way street, if it is shown it should be returned. Then there is the operator that let his senior seven pilots from a staff of 27 pilots go on the same day, because if he employed them any longer he would be required to contribute toward a retirement plan. I was one of the seven that was let go.
My point is, if I'd been in the group of 20 less-senior pilots that this company retained, I would have had my radar up for a new position regardless of the time or circumstance.
It's important to realize as a young pilot—let me restate that—realize as a pilot in this industry you will never know everything. As a young pilot in particular it's important that you have mentors that you feel comfortable with. A chief pilot should always see this as one of his responsibilities, not that he has to be the mentor himself, he may not have the time, but he should ensure that the less-experienced pilots on staff have a person to go to.
When I came back from Vietnam and entered the commercial market, the average age of helicopter pilots was probably 24. There were some older pilots around at that time and several of them extended their hand to me as a mentor, for that I thank them from the bottom of my heart.
Today all of us Vietnam-era pilots are at the end of our careers, the pilots that helped us many years ago are watching how we treat this younger generation. Let's not disappoint them. For older pilots, if you are fortunate enough to train in simulators use them for everything they are worth. Care about your performance in the simulator. Keep an open mind towards changes in your flying habits that the instructors suggest.
Remember that you'll be as good a hand skills pilot as you will ever be by the time you have 3,000 or 4,000 hours. It's your ability to remain focused and committed to your flying mentally that separates the good pilots from the excellent.
My last thought on this is I think that a company atmosphere that encourages the pilots to share ideas, problems and solutions is the first step toward the safety culture that IHST (the International Helicopter Safety Team) has identified as the answer to reducing accidents in the helicopter industry.
I always use my former employer, Los Angeles County Fire, as an example because that's what I know best. When I left, every pilot had more than 10,000 hours, egos—what would ever make you think that?
But here's my point—not all of the pilots got along with every other pilot, but all of the pilots had at least three or four guys that they could relate to and feel comfortable with. Many years back, one pilot that we had recently hired isolated himself as the only keeper of the flame. He was fired.


text: ESWAT: City Under Siege - Achievements ESWAT: City Under Siege is a platform game developed by Sega and released on Microsoft Windows, Sega Genesis, Wii.Here you will find a list of all achievements and trophies available in the game. Jump to a section: Home Releases Credits Overview Walkthrough Achievements Cheats Share Achievements with others < Prev: Walkthrough Next: Cheats > Do you want to earn money creating pages just like this? Gamewise is currently looking for writers, find out more here. Around the Network ESWAT: City Under Siege Brainwaves View all → ESWAT: City Under Siege Achievements


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S&B Cold Air Intake System 75-5059
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S&B Cold Air Intake Kits are engineered to maximize the amount of airflow to your vehicle's engine. Tested to the ISO 15011 standard, the same tests used by Ford, Chrysler, and GM to design the original induction system in your vehicle. S&B, however, takes it a step further using their extensive research and development to craft some of the best Cold Air Intake Systems on the market.
Factory intakes can't compare to the unreal airflow provided by S&B Cold Air Intakes. Among their innovations is their custom air box. It's design keeps unwanted engine air & loose dirt out of your system while providing protection to your air filter. It's clear top, an industry first, allows for easy inspection.
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The purpose of this second paper is to give an outline of the physiology of the brain's control of eye movements as an outstanding example of a biological computerised control system.
This is the first of two papers whose aim is to review briefly how our eyes move and how eye movements are controlled, as another example of awe-inspiring precision engineering by the Almighty.
This article reviews reasons for our having the inverted retina and why the the verted retina would be liable to fail in creatures who have inverted retinas.
No results found in .
Answers in Genesis is an apologetics ministry, dedicated to helping Christians defend their faith and proclaim the gospel of Jesus Christ.


text: Do we really understand what's happening here? Ian Waldie/Getty Images hide caption toggle caption Ian Waldie/Getty Images Opinion 13.7: Cosmos And Culture Are The Mind And Life Natural? October 12, 2012 Can natural science find a place for us in its vision of the cosmos? Thomas Nagel, in a new book, demands we take this question seriously. He is right to do so.


text:
First Years
Best Seller - Suitable from birth
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Easy for little hands to use
Rattle in the head and crinkle sounds
Made from soft plush and corduroy for different textures
The hugely popular Squeakaboos! soft toy rattles make the perfect toy for babies from birth to a year and have been an instant hit bringing smiles, giggles and laughter to little faces all around the world.
Crafted from vibrant and soft plush fabrics, each Squeakaboo has a cute shaped face with a kind, gentle smile. Perfect size for tots, babies will instantly warm to the Squeakaboos, and will love to touch, hold and shake them! And when they do, theyll be enthralled by the jingly rattle and squeaker sounds. And whats more, once they start to explore the Squeakaboo, they will be further fascinated by the crinkle-sounding material sewn into the head. Squeakaboos.
An ideal first toy for cot, playmat or in the carseat, Squeakaboos are adorable little first friends that will captivate and help encourage babys first discoveries. Great for playing peek-a-boo!; even the adults can join in the fun!
Squeakaboos make a fabulous baby gift and attached, you will find a gift tag ready to be filled in (if you can bear to give it away). Available in bright vivid colours as: - Giraffe, Elephant, Lion, Penguin, Monkey, Cow, Sheep, Duck, Pig, Dog and Cat and as Cuddles style, with natural undyed soft fluffy fabric: Mouse, Sheep, Dog, Bear, Chicken and Duck.
Available individually or as gift sets. Squeakaboos measure approx 18cm high, and can be machine washed at 30 degrees.
Age: 0+ (6 x 19 cm)
Code: T-2514
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The door body lifting mode selection can be based on the following basic requirements: the size of openings; the space on the upper part of the door; the door side space; the depth. According to the actual condition of the building site, with the owner of the space requirements, you can achieve the following several ways to upgrade, the maximum to meet the requirements of the rational use of space.
4, inclined top lifting: applied to the top of the door ceiling slope shape, the track into a parallel state and the ceiling.


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Hi all,
New to piano and Blues. I started playing this past May (I am playing a Yamaha YPG 635) and am still very much a novice at piano.So, please forgive me if I this question sounds sort of obvious to you more knowledgeable types.
A friend plays the harp and got me interested in blues. I now incorporate some blues scales work in my practice sessions. But, I have a question...How do I tie the different scales together so they flow? In other words, if I am running some riffs in the C Blues scale, how do I switch smoothly to say the G or the F etc? Are there some that compliment each other better?
Also still working on getting the right hand to play a riff while the left hand is playing a bass line! I think this is the hardest part of learning to play! My right hand keeps wanting to do what the left is doing!
Anyway, thanks in advance for any tips! I am really ejoyig learning about how the music comes together and actually playing the piano and not having it sound like a skunk in heat! (I actually have o idea what that sounds like! )


text:
Raining Images Home Decor Design Line
Clematis ~ Flutter ~ Grape 1 ~ Grape 2 ~ Grape 3 ~ Lemon Tree ~ Moon ~ Peacock ~ Roses ~ Sun ~ Sunburst ~ Wine Bottles
View Home Decor Designs (link opens in new window or tab).
Personalize any gift or gear item - choose a Raining Images style and then add your words, name, etc. Several of these designs are styled to use together for multiple-tile items such as trays.
Then choose what item you want to put the print on in the Personalized Gifts & Gear section.


text:
Apocalypse – No! Book Chapters
- About
- Culture War, Class War – Book 1
- Apocalypse Emergency – Book 3
- Apocalypse No – Book 4
- Ch 1 Strange Days
- Ch 2 "Ain't Born Typical"
- Ch 3 Perinatal Media
- Ch 4 – 21st Century, Its Discontents
- Ch 5 Birth Wars, World Woes
- Ch 6 Healing Crisis
- Ch 12 Through Gaia's Eyes
- Ch 8 Derailing War, Violence
- Ch 9 Regressions in the Service of Society
- Ch 10 Cultural Rebirthing, Where Lies Hope
- Ch 11 Control vs. Surrender
- Ch 12 Atman Projects vs. Surrender Solutions
- Ch 13 Peaceful Warriors, Silly Heroes
- Ch 14 To Move the World
- Afterword: Shamans … Scapegoats
- Wounded Deer and Centaurs – Book 5
- Prologue: For Earth's Sake, Get Real
- Chapter One: We Are a Fever
- Chapter Two: Ain't Born Typical
- Chapter Three: Projecting the Perinatal Zeitgeist
- Chapter Four: 21st Century and Its Discontents
- Chapter Five: Prenatal Imprints of Our Unnatural Self
- Chapter Six: Prenatal Oxygen Hunger and Fire
- Chapter Seven: Civilization and Apocalypse
- Chapter Eight: Return of the Centaur
- Chapter Nine: Prenatal Hunger Games
- Chapter Ten: "Bad Blood"
- Chapter Eleven: Prenatal Irritation-Revulsion
- Chapter Twelve: Toxic Womb ~ Toxic World
- Chapter Thirteen: Perinatal Printouts of Generations
- Chapter Fourteen: Birth Wars ~ World Woes
- Chapter Fifteen: The Unsung Consciousness Revolution
- Chapter Sixteen: Eden Arise, Call to Centaurs
- The Great Reveal – Book 6
- Experience Is Divinity – Book 7
- Falls from Grace – Book 8
- Culture War, Class War Blog
Recent Posts
- *Apocalypse NO: Apocalypse or Earth Rebirth & the Emerging Perinatal Unconscious* (2013) by Michael Adzema. (complete book, with my compliments)
- belief/religion/ritual *keep real* feeling *from happening*. They also keep truth from happening. They keep spontaneity and authenticity from happening. Therefore, when religion breaks down, all truth is liable to break loose.
- "your position on the abortion issue is the closest thing to a military uniform indicating on which side of the culture war you have enlisted" and what generation you are most likely from: Sixties & Millennial Generations Versus Gen X, and WWII and Fifties Gens
- the opposite of insanity is not normality … at all! The only sane response in an apocalypse emergency — a situation analogous to one's house on fire — is activism!"
- We learned, early in our lives, the world could not be relied on. We began an ever-increasing mistrust of it, which manifested, critically, in our relation to Nature. Control came in to fill the gap of mistrust that lay between need and satisfaction.
- the Universe has already experienced such apocalypse, now just a red planet…. It was much more fun, filled with life, creative divine noises, and manic whacky Chaplinesque movements, sounds, color, laughter… Instead,why not a hero's tale, billions of heroes…
- Republicans' intention is to cobble the ordinary person's power to get out from under the inexorable increase in their clearly felt suffering as the years go by. For this suffering and the helplessness about it is crucial to the directors' success.
- And so it began, with the blissful knowledge of Unity with All That Is turning psychotically into "I AM the Unity, I am all that is." So it went. I don't know why. But then there is that thing about it all being about greater wisdom…
- People *Are* Dying from Oxygen Deprivation … even the minute changes in our global atmosphere on the whole are having pervasive and dire consequences…
- this idea of getting more power at the cost of others' suffering — whether a "beast," an enemy, a slave, a prisoner of war … or one's own son — is rooted deeply in our cultural practices from the times of early civilization.
Tweets .. Join Me!
- WDC 2/92 Can we see how convenient it is for modern families, requiring two incomes to keep themselves in house & s… twitter.com/i/web/status/1…@sillymickel 11 minutes ago
- Grof made his determination that depression is rooted in birth experience based upon tens of thousands of sessions… twitter.com/i/web/status/1…@sillymickel 1 hour ago
- WDC 2/91 With civilization comes extraordinary increase in time req. to survive & w that comes a strong tendency to… twitter.com/i/web/status/1…@sillymickel 2 hours ago
- A Cosmic Slap: I Was Told "Once There Lived "Noble" Beings" and Now Is the Time for a Regeneration of Peoples to Re… twitter.com/i/web/status/1…@sillymickel 3 hours ago
- WDC 2/90 *Primal Vs "Civilized" Societies in Noticing the Unborn*…Whereas with civilization comes an extraordinary… twitter.com/i/web/status/1…@sillymickel 4 hours ago
- Furthermore, my personal experience with depression earlier in my life & my primal re-experiencing of prenatal, wom… twitter.com/i/web/status/1…@sillymickel 5 hours ago
- WDC 2/89 "primal" societies—whose members need only 3-4 hours/day of work to survive—are much more likely to acknow… twitter.com/i/web/status/1…@sillymickel 6 hours ago
- *"We must implicate proxy dads, & evil kings, foreign enemies & minorities, to portray the father we cannot bear to… twitter.com/i/web/status/1…@sillymickel 7 hours ago
- WDC 2/88 These "primal" societies & indigenous cultures—who have been found on average to have required only 3-4 ho… twitter.com/i/web/status/1…@sillymickel 8 hours ago
- RT @sillymickel: If you don't read anything else by me, you should at least read this.... the kind of person that it would be of interest t…@sillymickel 8 hours ago
- RT @sillymickel: There are other falsehoods woven into the fabric of patriarchality with its ascension of the few at the expense of the mos…@sillymickel 8 hours ago
- RT @sillymickel: WDC 1/100 Like Joe in the Tom Hanks/ Meg Ryan movie, Joe Versus the Volcano, we just might find ourselves "jumping into th…@sillymickel 9 hours ago
- RT @sillymickel: The Earth Speaks Out on Love, Death, & Liberation: Breadcrumbs from Divinity, & Matter Is Message … One's Experience of Re…@sillymickel 9 hours ago
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- RT @pepper55bs: I like your writing you are a good man I think, wheres your heart in resistance or acceptance? twitter.com/sillymickel/st…@sillymickel 9 hours ago
- resist to death, if necessary, the downfall of civility, democracy, freedom, peace, & sanity under Trump & all Repu… twitter.com/i/web/status/1…@sillymickel 9 hours ago
- It is *experience*, individual *experience*, that we as God want to contrast so as to manifest it all more wonderfu… twitter.com/i/web/status/1…@sillymickel 9 hours ago
- RT @sillymickel: WDC 1/99 Whatever the particular thrust or direction of our efforts toward change, I believe that those of us who take on…@sillymickel 9 hours ago
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- RT @sillymickel: WDC 1/98 They just might save us & our loved ones … & the innocents of all manner of beings. These wounded deer & centaurs…@sillymickel 9 hours ago
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Teacher resources and professional development across the curriculum
Teacher professional development and classroom resources across the curriculum
Getting Ready (20 minutes)
The following information will help you focus and organize your professional development session.
Learning Objectives
Guiding Questions
Materials and Resources
Opening Steps
Discuss your experience with having your students write critiques.
Discuss these questions:
Facilitator: If you have a videotape of Cirque du Soleils Quidam, use it to provide examples of historical references:
In the videotape, look for specific examples of:
To download PDF files, you will need a free copy of Acrobat Reader.
Workshop Home | Site Map | About the Workshop | Support Materials | Channel Talk
© Annenberg Foundation 2017. All rights reserved. Legal Policy


text:
Some Jews, Israel-backers fear Hagel
Some Jews and supporters of Israel voiced major concerns about the possible nomination of former Sen. Chuck Hagel to lead the Defense Department, taking to Twitter and the blogosphere this week to slam the Nebraska Republican.
"Send us Hagel and we will make sure every American knows he is an anti-Semite," a senior Republican Senate aide told The Weekly Standard. The aide continued, "Hagel has made clear he believes in the existence of a nefarious Jewish lobby that secretly controls U.S. foreign policy. This is the worst kind of anti-Semitism there is."
Story Continued Below
( PHOTOS: Chuck Hagel's career)
The Times of Israel reported that "the nomination of Hagel would likely worry Israel supporters, who have criticized the former Republican senator for what they see as a chilly stance toward the Jewish state."
The English-language Israeli publication cited Hagel's past positions on issues including the second Lebanon War in 2006 and Israel's dealings with former Palestinian leader Yasser Arafat.
"Now that the election is over Barack Obama no longer has to appeal to supporters of Israel or haters of terrorism — so he is about to appoint former Senator Chuck Hagel to replace Leon Panetta as Secretary of Defense," charged Jeff Dunetz at the blog Yid with Lid.
A top Israel advocate told The Daily Beast that "the pro-Israel community will view the nomination of Senator Chuck Hagel in an extremely negative light. His record is unique in its animus towards Israel."
( Also on POLITICO: 10 facts about Chuck Hagel)
Reports Thursday indicated Hagel is a likely pick for the top Pentagon position.
The Midwesterner has come under withering fire from some corners of the conservative and Jewish communities for his previous rhetoric and positions on Israel and Iran.
"He is one of the most hostile critics of Israel that has ever been in the Senate," Morton Klein, president of the Zionist Organization of America, told the newspaper The Algemeiner.
At the blog Israel Matzav, another headline read: "Bad news for Israel: Obama wants Hagel at Defense."
The piece then cited National Jewish Democratic Council talking points, which include Hagel's refusal to "write the EU asking them to declare Hezbollah a terrorist organization" in 2006; that "in October 2000, Hagel was one of only 4 Senators who refused to sign a Senate letter in support of Israel;" and that in 2005, he "refused to sign a letter to President Bush to pressure the Palestinian Authority to ban terrorist groups from participating in Palestinian legislative elections."
"Hagel was one of the most consistently anti-Israel Sens in modern history," tweeted conservative Philip Klein of the Washington Examiner. "Would be a great fit for Obama administration."
Hawkish conservatives also noted support Hagel has received from some who have taken a critical approach to Israel.


text:
You wrote: > In the CSS2 spec. there is a style sheet to represent the default behaviour > (i.e. style) that most browsers apply to HTML. However, there is the caveat > that certain things like the display of images in <img> cannot be expressed. > While this is not quite legal, has anyone considered the following:- > > @media screen { img { content: url(attr(src)); } } Yes they have. img {content: url()} is almost certain to be valid CSS3, and attr is proposed. -- Random fortune I feel ... JUGULAR ...Received on Wednesday, 22 November 2000 12:12:03 UTC
This archive was generated by hypermail 2.3.1 : Monday, 2 May 2016 14:26:55 UTC


text:
Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00975689
Recruitment Status : Completed
First Posted : September 11, 2009
Results First Posted : July 12, 2012
Last Update Posted : May 6, 2013
- Study Details
- Tabular View
- Study Results
- Disclaimer
- How to Read a Study Record
- Niemann-Pick disease type C (NPC) is a genetic disorder that results in progressive loss of nervous system function by affecting the membranes of nerve cells. There is no known cure for NPC.
- N-acetyl cysteine (NAC) is a drug that has been approved by the Food and Drug Administration to use either orally or IV for the treatment of acetaminophen (Tylenol) poisoning or as an aerosol to reduce the stickiness of mucous in patients with cystic fibrosis. In the body, NAC is converted to an amino acid called cysteine, which cells can convert to a chemical called glutathione. Glutathione is important in helping cells deal with oxidative stress. Based on a number of experiments in cells, mice and patients with NPC, we believe that oxidative stress is increased in NPC. If we can increase glutathione levels, we may be able to decrease the oxidative stress.
- To test the safety and effectiveness of N-acetyl cysteine to treat Niemann-Pick disease (type C).
- Individuals at least 1 year of age who have been diagnosed with NPC.
- Patients entering this study will be seen at the National Institutes of Health Clinical Center four times during the 20 weeks of the study. These admissions will occur at the start of the study and at weeks 8, 12, and 20. The first NIH visit will last 2 days, and the other visits will last 1 day.
- Patients will participate in a two-stage study: a period of 8 weeks receiving NAC and a second period of 8 weeks when receiving a placebo (a pill without NAC). Every patient participating in this study will receive NAC during one of the two time periods.
- The two treatment periods will be separated by a wash-out period, 4 weeks when patients will receive neither NAC nor placebo. Patients will also have a 4-week wash-out period at the beginning of the study. Most physician-prescribed medications, such as seizure medications, will be allowed.
- During each visit, examinations, procedures, and tests will be done, including blood and urine samples.
|Condition or disease
|Niemann-Pick Disease, Type C
|Drug: N-Acetyl Cysteine
|Phase 1 Phase 2
Niemann-Pick Disease, type C (NPC) is an autosomal recessive lysosomal storage disease with progressive neurodegeneration. It is characterized by intracellular accumulation of cholesterol and glycosphingolipids. The age of onset is variable with cases manifesting from infancy to adulthood. Classically, initial neurological symptoms are observed in early to late childhood. Symptoms and signs of NPC include prolonged neonatal jaundice, splenomegaly, and various neurological manifestations, especially ataxia, dysmetria, dysarthria, vertical supranuclear gaze palsy and cognitive decline. Currently there are no approved therapies for NPC. A recent controlled study and a series of case reports suggest some efficacy for miglustat. Miglustat inhibits the biosynthesis of glycosphingolipids. The pathophysiological processes contributing to neurodegeneration in NPC have been intensively studied in NPC mouse models. Potential pathological processes include toxic effects of cholesterol or glycosphingolipid accumulation, deficient oxysterol production, peroxisomal dysfunction, mitochondrial dysfunction, perturbed intracellular calcium homeostasis, inflammation, induction of apoptosis, deficient neurosteroid synthesis, and increased oxidative stress. The degree to which each of these pathological processes contributes to the pathology of NPC is not known; however, the multiple processes involved suggest that combinatorial therapy addressing various aspects of this disorder will be necessary. A major impediment to the development of clinical trials for NPC has been the prior lack of outcome measures. Identifying biomarkers was a major goal of our NPC natural history trial (06-CH-0186). We now have identified multiple biochemical abnormalities in our cohort of patients that may prove useful as biomarkers in a therapeutic trial. The next step is to attempt to validate these potential biomarkers in a therapeutic trial. Thus in this protocol we plan to evaluate the safety and efficacy of N-acetylcysteine to improve a group of biomarkers related to increased oxidative stress.
The goals of this protocol are:
- To validate the use of biomarkers in a therapeutic trial for NPC.
- To evaluate the safety of N-acetylcysteine in NPC patients.
- To evaluate the efficacy of N-acetylcysteine to improve biomarkers associated with increased oxidative stress in NPC patients.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|35 participants
|Intervention Model:
|Crossover Assignment
|Triple (Participant, Care Provider, Investigator)
|Primary Purpose:
|Official Title:
|Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine
|Study Start Date :
|August 2009
|Actual Primary Completion Date :
|November 2010
|Actual Study Completion Date :
|November 2010
- Drug: N-Acetyl Cysteine
900mg effervescent tablet; Dosed as 15 mg/kg/day (maximum dose 900 mg per day) for one week, advanced to 30 mg/kg/day (maximum dose 1800 mg per day) for the second week, and then advanced to 60 mg/kg/day (maximum dose 2700 mg) for the remainder of the trial (6 additional weeks).
- Oxysterol Levels [ Time Frame: Six months ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|12 Months and older (Child, Adult, Older Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
All patients with an established diagnosis of NPC will be considered for this study. The diagnosis may be based upon either molecular or biochemical testing.
- Diagnosis of NPC by cellular assay or molecular testing.
- Twelve months of age or older and weight greater than 10 kg.
- Patient must be able to take the study medication orally or per gastrostomy tube.
- Patients will be excluded if they cannot travel to the NIH because of their medical condition or are too ill to be cared for at home.
- Patients will be excluded if they are unable to tolerate the study procedures.
- Patients will be excluded if they are pregnant (a negative urine pregnancy test will be required for any menstruating female before participation in this study and at each NIH Clinical Center admission). If sexually active, contraception must be used for the duration of the study.
- Patients will be excluded if they have had prior allergic or hypersensitivity symptoms associated with NAC use.
Patients will be excluded from the study if they are unwilling to discontinue the following drugs and supplements for the duration of the study.
- a. All dietary supplements
- b. Any antioxidant supplement other than prescribed by the study. This will include dietary juices or drinks being marketed as a source of antioxidants
- c. CoQ10 supplements
- d. Any over-the-counter medication being used on a daily basis for which there is not a defined clinical reason
- e. NAC use
- Physician prescribed medications will be reviewed on a case-by-case basis. Patients may be excluded if medical therapies could interfere with the study endpoints. Except for carbamazepine, seizure control medications will be allowed. Patients will be excluded if taking carbamazepine or nitroglycerin.
- Over-the-counter medications use on a daily basis will be reviewed on a case-by-case basis. Patients may be excluded if medical therapies could interfere with the study endpoints.
- Patients will be excluded if they have an uncontrolled seizure disorder.
- Patients on miglustat at the start of the study will be excluded if the dose of miglustat cannot be held constant for the duration of the study. The miglustat dose must have been constant for two months prior to the baseline NIH evaluation. Patients will be withdrawn if they initiate miglustat use after entering the study.
- Patient who are at risk for gastric hemorrhage (preexisting esophageal varices or peptic ulcer disease).
- Patients on a sodium restricted diet for medical reasons.
The following laboratory test abnormalities will exclude patients from the study:
- a. AST or ALT elevated greater than 4-fold upper limit of normal. Note: NPC patients frequently have transaminase levels 2-3 fold above normal.
- b. Anemia defined as two standard deviations below normal for age and gender.
- c. Platelet count less than 75,000.
- d. Elevated serum creatine level
- e. Hematuria or proteinuria
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00975689
|United States, Maryland
|National Institutes of Health Clinical Center, 9000 Rockville Pike
|Bethesda, Maryland, United States, 20892
|Principal Investigator:
|Forbes D Porter, M.D.
|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Additional Information:
|Responsible Party:
|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|ClinicalTrials.gov Identifier:
|NCT00975689 History of Changes
|Other Study ID Numbers:
|First Posted:
|September 11, 2009 Key Record Dates
|Results First Posted:
|July 12, 2012
|Last Update Posted:
|May 6, 2013
|Last Verified:
|April 2013
Keywords provided by National Institutes of Health Clinical Center (CC) ( Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) ):
Niemann-Pick Disease, Type C
N-Acetyl Cysteine
Oxidized Cholesterol
Additional relevant MeSH terms:
Pick Disease of the Brain
Aphasia, Primary Progressive
Frontotemporal Dementia
Niemann-Pick Diseases
Niemann-Pick Disease, Type A
Niemann-Pick Disease, Type C
Frontotemporal Lobar Degeneration
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms
TDP-43 Proteinopathies
Neurodegenerative Diseases
Proteostasis Deficiencies
Metabolic Diseases
Lysosomal Storage Diseases, Nervous System
Brain Diseases, Metabolic, Inborn
Brain Diseases, Metabolic
Histiocytosis, Non-Langerhans-Cell


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Away We Go - Lots Of Letterpress Ink
This invitation designed by the groom Tyler Thiessen at Neuhaus Design and illustrated by bride Jessie Turner makes their wedding invitation into a fresh art print. It is nice to see a wedding invitation that is illustration centric versus type heavy. They put all the text on the web. You can check out the couples wedding website here. The illustration is simple with just a little overprinting of bright red and light blue inks. Most of the artwork knocks out, requiring very tight register. (like the blue dotted lines on the hot air ballon.) It is printed on Crane Lettra Flo. White 110lbC The card is like a small poster and folds up to a 5.5 x 5.5 square.
We won't mince words, this was a hard invitation to print with letterpress. Registration was tight, and the paper does stretch with heavy impression over a solid graphic area. Plus, large areas of solid color are not ideal for letterpress. Letterpress is definitely not like screen printing these kind of solid colors. Most letterpress equipment will not be able to handle this kind of press work. We printed this one on a Heidelberg Cylinder that has the impressional strength to lay down some pressure. Chances are if you send an invitation our way with a lot of ink going down you will get an email with our handy disclaimer that goes something like this. Once all this is understood we can move to press. And as you can see, we DO print areas of solid color and it can turn out very beautiful. Just realize there WILL be variation within the job that is inherent to printing this type of work with letterpress.


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Dr. James G. Pierce
Director of Publications
Phone: 717-245-4138
Dr. James G. Pierce is a retired U.S. Army colonel and is currently the Director of Publications, Strategic Studies Institute, U.S. Army War College, Carlisle, PA. As a career officer on active duty, Dr. Pierce served in a variety of command and staff positions. These assignments included: Commander, Eastern Army National Guard Aviation Training Site, Fort Indiantown Gap, PA; Director, Strategic Leadership Studies, Department of Distance Education, U.S. Army War College, Carlisle, PA; and as a senior advisor to the Iraqi Security Forces Deputy Chief of Staff for Training and Doctrine. As a Department of the Army civilian, Dr. Pierce was also the Director, Army Transformation Team, Army G-8, for Stryker Brigade Combat Team-6. His research and writing interests include organizational theory, leadership and decision-making theory, and public ethics. Dr. Pierce received a B.A. in political science from LaSalle College, Philadelphia, PA; an M.S. in systems management from the University of South California, Los Angeles, CA; a master's degree in strategic studies from the U.S. Army War College, Carlisle, PA; and a Ph.D. in public administration from the Pennsylvania State University, Harrisburg, PA.
SSI books and monographs by Dr. James G. Pierce
Is the Organizational Culture of the U.S. Army Congruent with the Professional Development of Its Senior Level Officer Corps?
September 02, 2010
Authored by Dr. James G. Pierce.
In this study of the organizational culture of the U.S. Army, Dr. Pierce has reviewed a previously assumed but unverified connection between organizational culture and professional development. The study has uncovered a lack of congruence between the dominant type of organizational culture of the U.S. Army and the professional managerial/leadership skills of its senior level leaders. This observed lack of congruence may be inhibiting performance and unconsciously perpetuating a cycle of caution and an overreliance on stability and control. The data indicate that the U.S. Army is illustrative of an organization that emphasizes stability and control, and one that attempts to comprehend the ambiguity of the future through an unconscious reliance upon the successful solutions employed in the past.


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|MLBPA/MLB News Release
Major League Baseball and the Major League Baseball Players Association formally announced today the creation of the Puerto Rico Summer League, which began play on June 3. The two parties announced the details of the league during a press conference this afternoon at the El San Juan Hotel in Carolina, Puerto Rico, which included Rob Manfred, MLB's chief operating officer; Tony Clark, executive director of the MLBPA; Hector O'Neill, mayor of Guaynabo; Jose G. Rodriguez, mayor of Mayaguez; Kim Ng, MLB's senior vice president, baseball operations; Jorge Perez Diaz, Esq., MLB advisor, international operations; Bobby Bonilla, MLBPA special assistant, player services, events/Players Trust; Jose Cruz, Jr., MLBPA special assistant; Javier Vazquez, MLBPA international special assistant; Carlos Delgado, former All-Star first baseman; Candy Maldonado, former Major League outfielder; and Alex Cora, former Major League infielder.
The Puerto Rico Summer League is a joint initiative that MLB and the MLBPA created to support the collective commitment of both organizations to the development of youth baseball in Puerto Rico. The newly created league will give Puerto Rican players between the ages of 14 and 17 more opportunities to play baseball during the summer. The league, consisting of two four-team divisions, will run for eight weeks in June and July in the cities of Guaynabo and Mayaguez. In Guaynabo, games will be held at Estadio Moises A. Garcia Quintana, which has hosted free one-day umpire camps in each of the last two years, while games in Mayaguez will be played at Isidoro Garcia Stadium. Each division's four teams will hold professional-style practices at each of the facilities, with two games played at each site on Tuesdays and Thursdays.
Players for the league were selected through tryouts conducted throughout the island in conjunction with the various leagues in Puerto Rico.
Among the coaches who will participate in the summer league are Jorge Aranzamendi; Edwin Cintron; Pedro Ethier; Abdiel Figueroa; Fernando Figueroa; Fernando Gonzalez; Ivan Maldonado; Julio Martinez; Witito Martinez; Josue Matos; Luis Matos; Orlando Mercado; Angel Molina; Mako Oliveras; Johnny Pagan; Jayson Perez; Luis Raul Quinonez; Jose Luis Rodriguez; Victor Rodriguez; Omar Rosado; and Alexander Woodson. Of the 21 coaches, 16 have instructed at the MLB Development Program, an after-school training program in Puerto Rico for high school athletes that launched in May.
"For decades, the island of Puerto Rico has left an enduring imprint on the diversity of our game," said Manfred. "Major League Baseball remains dedicated to providing ample opportunities for the youth of Puerto Rico to participate in the game year round. In the spirit of our other local programs, such as the Puerto Rico Baseball Academy and the Passed Over Showcase, the Puerto Rico Summer League will serve as an immense resource for those players who wish to remain on the field during the summer months, while also presenting the Major League Clubs with an additional outlet for scouting."
"Increasing and advancing playing opportunities for young players is a priority of active Major Leaguers, in general, and Puerto Rican players, in particular, especially opportunities that provide young players with expert coaching and training," said Clark. "Puerto Rico has produced some of the greatest players to have played our great game, and the creation of the new summer league honors previous generations of Puerto Rican Major Leaguers and provides a new path for future generations to follow."


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Do the Lions go with an offensive lineman or a defensive player with their fifth overall pick in the NFL draft?
Two national experts are divided. So I'll break the tie.
First, there's no doubt Chance Warmack is a tremendous talent at guard - and the Lions have an opening at right guard - still it would be a surprise to see the Lions draft Warmack with the fifth overall pick when there are other pressing needs.
Warmack (Alabama) had a pre-draft visit with the Lions on Monday according to the team web site.
'(Warmack) is certainly a great player. I just think if you look at this (NFC North) division if you can get a (cornerback) Dee Milliner or a pass rusher that will help against the Aaron Rodgers, Jay Cutlers and people like that ...,'' ESPN draft analyst Mel Kiper said in a conference call on Wednesday.
'The two quarterbacks in that division, of course led by Aaron Rodgers, you have to go through to get a playoff spot. I think a cornerback or defensive end would be the guys to consider ...
'Warmack is a heck of a player - helping out obviously the running game, a run blocker and help protect Matthew Stafford,'' Kiper said. 'I would be surprised if they don't draft a defensive end or corner.''
I'm with Kiper on this one. I think with so many needs on defense, that's the direction the Lions have to take with their top pick.
Todd McShay, another ESPN analyst, released his mock draft Wednesday and has the Lions drafting offensive tackle Eric Fisher (Central Michigan, Rochester Hills' Stoney Creek).
That's McShay's first scenario. His second would be Milliner and his third is defensive end Ziggy Ansah.
McShay has Warmack going to Buffalo with the eighth overall pick while Kiper has him going to Tennessee with the 10th pick.
The three-day NFL draft, which starts April 25, is just two weeks away.
Of course Lions general manager Martin Mayhew won't tip his hand. Everyone seemed surprised when he drafted tackle Riley Reiff in the first round a year ago.
Mayhew goes for the best available player. Will he surprise us again this year?
Follow @PaulaPasche on Twitter. Her new book, '100 Things Lions Fans Should Know & Do Before They Die,'' is available at bookstores.


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Ever happened to you that your employee used the wrong document and caused a mass? Ever happened to you that a classified information reach the wrong hands and embarrassed you? Ever happened to you that you lost an important document and knew that your boss would get angry? For no reason? If do, please pay attention!
Using Document Control Software usually meets the ISO 9001 Standard Document Control Requirements. The document control requirements is one of the key elements of the ISO 9001 Standard requirements for achieving an effective quality management system. Without reliable control of procedures and records, a company's QMS integrity will fail – as a practical business matter and as an auditable compliant system.
There are many solutions today for Documents control both manual and digital. In this article I will examine how one can achieve the requirements with digital solutions. Pay attention, we didn't write software but a digital solution. Digital solution must not be a document control software
There are two kinds of documentations in organizations. The first is the ISO 9001 documentation requirements. For The second, (other than is required) the organization must identify and document "needed" processes (activities with inputs and outputs). Of course documentation should be appropriate for the size and type of the organization, the complexity and interaction of processes, and the competence of personnel. In other words, don't go over your heads, you would regret it in the future. The purpose is not to turn the organization to be a secretary for the ISO 9001 Standard.
The first level of digital documents control
The first level of digital documents control over organizations is laid with its management systems. Management systems are software designed to support some of the working processes. The system can be an ERP system, a CRM system or any other system. As long that it documents the working processes. Within the system forms are implemented (screens). The system guides you to fill the correct information at the correct location. Eventually, the information is at the right place and time, organized and being controlled. Even distribution of the information is managed. This is what documents control is all about. So, when you are documenting your QMS and prepare yourself for the terrifying audit, any process that is included within the QMS and is documented via the management system – is covered. But you will have to mention it in the procedure. Don't say I didn't tell you.
Basic electronic systems
The most common digital way today is still using the local computer network and email systems for documents control. The Documents management is usually being realized when folders or directories are established and usually it is done locally (a department or a division). The documents are saved on the server for use. Sometimes the system administrator or maybe the quality manager requires that the document would be protected by any changes – the "read only" possibility. The types of documents are varying from forms, procedures, records, plans, work instruction, diagrams etc.
As for routing documents, the email as become the main communication channel. People send as attachments documents for review or for use.
Now, you may think that this is a digital documents control but in fact you only get digital documentation but no control what so ever! Why? First, when you save a document on the server it is actually a manual management and not a digital management. It is correct, the document is digital but the management is manually. The employee saves it in the folder and names the document. He has full control over it. God knows what he is capable of doing with it. Digital document management requires that the document would be submitted via the documents control management system. This way, the system is registering the document and then begins managing his lifecycle. Now, no employee of yours registers any document that he saves on the local net. Correct me if I am wrong.
Second, when you send an email with an attachment it is like exporting a document out of his system and into an individual independent lifecycle. The person who receives this attachment would probably save the massage with the document and whenever he would need it, he would brows through his mails the get the document. Everybody does it. He could make changes and you wouldn't know anything about it. Tracking those documents, comments made by reviewers, and the final approval history are not automatically accessible in a manual email routing system (which are the common ones). Even if documents are sent through email, system administrators must manually track, update, and communicate the review they receive. To make it more clearly, it is an open loop system. Not to mention the ineffective storage results.
With digital document management system you won't send the document but a link or any other trigger to access the document via the documents control management system.
Third, even when you save a document and you characterize it as "read only" – that prevents no one from saving the document on his computer, edit it and spread it throughout the organization. Again you are back to an open loop system. Sorry. O.K. Even with the strongest most sophisticated digital documents control management systems you can never, really, prevent that. No matter what anyone tells you. You are depending on your employee and his willing to follow ground rules to ensure regulatory compliance. At the end of the day, we are stuck with the human factor.
So with manual (as if – digital) document control we achieve three things: an open loop method for document management, a document exporting out of the loop and an independent lifecycle for documents. The three things the ISO 9001 Standard is trying to avoid.
Solutions Solutions
The first solution that we offer you is to maintain the present situation (the manual, so called "digital", management). You must have to support it with documented procedure that describes how one must handle documentation (that is the ISO 9001 Standard requirement) and maintain close control aspects. That would hold against the ISO 9001 Standard but I recommend to overview the requirements just to be sure that you obtain the requirements.
The second solution that I can think of is documents control via the management system. What I mean is that all documentation would be concentrated at one location. Documents are a part of a processes. Some of the processes is documented within the management systems (such as ERP or CRM) and some of it manually (with manually forms). In most systems (the ones that I know) the next module exists. It is a less used module. It is usually called "Titles Management". The basic idea is to link documents to the process or a record connected with the process within the system. This way you educate the employees to download the documents from one location only. No more documents emailing, no more saving documents on personal computers. This solution requires that all documents would be registered within the system (what a whole a lot of work!). For more details, access your system administrator. This solution is not the perfect one but it would hold against the ISO 9001 Standard requirements. Don't forget to document the method in a procedure.
If you are willing to invest more of your resources you might consider implementing documents control management software.
Documents control management system
Now, this is the optimal solution. Every quality manager would sleep better at night if he knew that all documents are controlled by a robot (without any feelings and wills other then what is programmed into him). Let's review the advantages of implementing document management software:
This solution costs. It costs money and human resources – have no doubts about that! But we truly believe that in the long term it pays itself by adding values to the working processes. All of the advantages above are possible to achieve manually by your employees but they are time consuming. And time is money.
Today there are two possibilities of digital documents control systems: web-based and independently installed.
The web based solution is simply subscribing to a web site that provides you documents control service. That means that the entire above are provided via the internet. Sounds great isn't it? As an Internet service, there is no software or hardware to buy, install, maintain, or upgrade. And if the service is not satisfying, just unsubscribe. That's it. You may access from wherever you are and provide workspaces for people working from home.
The independently installation is where you purchase a software and install it no your network. You may want it to integrate with your other systems. Now, that will be great for a working process! Today they are usually easy to implement and easy to use and with prices that won't get your boss upset (too much).
As for more documentation (other than what is required by the ISO 9001 Standard) the organization must identify and document "needed" processes.


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Tim Garson: Fit to be bow-tied
Now finishing his first year at the UVA medical school, Arthur "Tim" Garson Jr. has been here long enough for people to wonder why someone named Arthur is called Tim, and what's with the bowties?
Sporting the school colors with a navy and orange bowtie, set off by his white medical jacket, UVA's new vice president and dean of the School of Medicine clears up these mysteries.
"I was a preemie," he explains. "I weighed under five pounds. My parents wanted to name me Arthur, but I became known as Tiny Tim, and it stuck from day one."
As for the bowtie look, Garson credits the single best teacher he had during his first year in med school for influencing his choice in neckwear. "It made him distinctive," he says. As only one in a class of 105 students, Garson decided that wasn't a bad thing to do himself.
Not that there have been all accolades for his fashion sense. The pediatric cardiologist recounts how he was wearing a particularly "bright" bowtie while speaking at Baylor, when he noticed heart transplant pioneer Denton Cooley laughing during his presentation. When he inquired afterward, Cooley said he used to have a bowtie and shirt like Garson's, but his wife wouldn't let him wear it.
Garson's Cavalier-inspired bowtie was purchased last year after he was offered and accepted his current job. "I thought it was a good idea," he says.
And he offers this nugget of information: His bowties are made from two regular ties. Garson bought eight Cavalier ties, took them to Houston and had them made into four bowties, his first significant investment in his new job.
But Garson isn't here just to make a fashion statement. The former Baylor dean, who also was an associate vice chancellor at Duke, where he went to med school, is charged with keeping UVA Medical Center a top facility.
He's unveiled six models for excellence that he hopes will become models for the rest of the country over the next decade.
And he's open to input from other disciplines such as business, law, chemistry, and physics. "That's what's fun about being in a top public university: the people here," he says.
As if his administrative visionary plate weren't full enough, Garson also still teaches and actually sees patients. Every few weeks, he loads up residents and fellows, and lectures them during the four-hour round trip to a field clinic in Winchester. "It's really the best use of my time," the top doc says.
If he ever gets tired of medicine, Garson has a backup plan– and it doesn't involve fashion. Read on for his well thought-out Walter Mitty fantasy.
Age: 54
What brought you here? Collaborative and innovative faculty; extraordinary university leadership
What's worst about living here? Waiting a year for my family to move (which they now have!)
Favorite hangout? New friends' houses; people have been wonderfully welcoming.
Most overrated virtue? My medical writing; I wish I could write short stories.
What would people be surprised to know about you? I used to sell women's lingerie.
If you could change one thing about yourself, what would it be? Answer emails tomorrow instead of right now but I can't.
What accomplishment are you proudest of? I'm proud of developing a national healthcare plan.
What do people find most annoying about you? Email at 3am
Whom do you admire? FDR, Colin Powell, and Karen Davis, president of the Commonwealth Fund
Favorite book? E.B. White's One Man's Meat, a compilation of short stories
What subject causes you to rant? The uninsured (for healthcare)
What thrills you about life in the 21st century? The Internet
What creeps you out about life in the 21st century? The prediction of three to four careers per person
What do you drive? BMW
What's in your car CD player right now? Handel's Messiah
What's your next journey? Helping to operationalize a 10-year strategy for the School of Medicine and Health System
What's the most trouble you've ever gotten in? Painting the library dome pink in high school
What do you regret? Not taking more art courses in college
Favorite comfort food? Chocolate
What's always in your refrigerator? Grapes, and I don't really like them, either.
Must-see TV? Dobie Gillis
Favorite cartoon? Peanuts
Describe a perfect day. Beach
Walter Mitty fantasy? Owning and operating a combination French restaurant and art gallery
Who'd play you in the movie? Dustin Hoffman
Most embarrassing moment? Taking a live microphone to the men's room during a conference
Best advice you ever got? Don't ever be in charge of parking.
Favorite bumper sticker? Healthcare for all of U.S.


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CHAPEL HILL, N.C. (MarketWatch) — The Dow's struggle to eke out even a minuscule gain for April reminds me of the story of Phidippides, in whose honor the marathon was created.
We can only hope that it's an inappropriate analogy.
Phidippides, of course, was the professional runner whom the Athenian army sent to deliver a message from the plains of Marathon to Athens, 26.2 miles away. After arriving, he collapsed in exhaustion — and died.
Like Phidippides, the Dow Jones Industrial Average DJIA, -2.37% has exhibited great strength and endurance — up 25% since last October's low. Furthermore, April represents the seventh month in a row in which this benchmark has gained.
But, far from painting a picture of strength in recent weeks, the Dow has displayed utter exhaustion. Weak as it has been, the other major indexes have been weaker still; the S&P 500 SPX, -2.59% actually lost ground for the month of April.
Also, as I pointed out last week, the Dow Jones Transportation Average DJT, -3.31% — the second of the two Dow averages on which Dow Theorists focus — has been markedly weaker over the last year than the Dow industrials. Read my April 27 column, "What market must do to avoid sell signal."
Such weakness and technical divergences would be a cause for concern at any time, but especially now, since April's passing means that the market's seasonally favorable six-month period has given way to the selling pressures associated with "sell In May and go away."
Another particularly negative factor the stock market must contend with is the increasingly pessimistic behavior of corporate insiders — companies' officers, directors and the largest shareholders, who have more insight into their firms' prospects than the rest of us. To be sure, the insiders are often early, so their recent selling doesn't immediately doom the market, even if they turn out to be right.
But it can't be good news that the insiders are betting so heavily against their companies' near-term prospects. After all, if they were confident that their firms' shares would soon be trading higher, they presumably would be buying rather than selling.
In fact, according to the latest issue of Vickers Weekly Insider Report, insider purchases are now rarer than they have been at any time since last July. You may recall that last August, a month later, the bottom dropped out of the market.
Not all signs point to lower prices, needless to say. The sentiment data are mildly positive, as I've reported in recent weeks. Read my April 11 column, "Only a modest correction ahead."
The investment advisers with the best track records over both the recent past and the longer term continue on balance to be more bullish than their poorer-performing brethren. Read the April 11 issue of Hulbert On Markets.
To convince us that it is healthy enough to escape Phidippides's fate, though, the market needs to exhibit a lot more strength.
Click here to learn more about the Hulbert Financial Digest.


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An education assistant for the Las Vegas City Schools has sued the district, saying it hasn't done anything to stop a male employee from repeatedly harassing her.
The harassment got so bad that the employee pulled up the alleged victim's shirt, according to the lawsuit, which was filed April 2 in state District Court.
The woman, represented by Albuquerque attorney Mark Jaffe, names as defendants the district, Superintendent Pete Campos and the employee in question.
If you currently subscribe or have subscribed in the past to the Las Vegas Optic, then simply find your account number on your mailing label and enter it below.
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Quit Smoking Tip Sheet
- Quit cold turkey. In the long run it's the easiest and most effective technique of smoking cessation.
- Do not carry cigarettes.
- Quit smoking one day at a time. Do not concern yourself with next year, next month, next week or even tomorrow. Concentrate on not smoking from the time you wake up until you go to sleep.
- Work on developing the attitude that you are doing yourself a favor by not smoking. Do not dwell on the idea that you are depriving yourself of a cigarette. You are ridding yourself of full-fledged smoking because you care enough about yourself to want to.
- Be proud that you are not smoking.
- Be aware that many routine situations will trigger the urge for a cigarette. Situations which will trigger a response include: drinking coffee, alcohol, sitting in a bar, social events with smoking friends, card games, the end of meals. Try to maintain your normal routine while quitting. If any event seems too tough, leave it and go back to it later. Do not feel you must give up any activity forever. Everything you did as a smoker, you will learn to do at least as well, and maybe better, as an ex-smoker.
- Make a list of all the reasons you want to quit smoking. Keep this list with you, preferably where you used to carry your cigarettes. When you find yourself reaching for a cigarette, take out your list and read it.
- Drink plenty of fruit juice the first three days. It will help flush nicotine out of your system.
- If feeling the need to eat extra food, to aid in avoiding weight gain, consider pre-cutting and keeping handy vegetables such as celery and carrots, and fruit instead of candies and pastries.
- If you are concerned about weight gain, do some moderate form of regular exercise. If you have not been exercising regularly, consult your physician for a practical exercise program which is safe for you.
- If you encounter a crisis, (e.g. a flat tire, flood, blizzard, family illness) while quitting, remember, smoking is no solution. Smoking will just complicate the original situation while creating another crisis, a relapse into the nicotine addiction.
- Consider yourself a "smoke-a-holic." One puff and you can become hooked again. No matter how long you have been off, don't think you can safely take a puff!
- Don't debate with yourself how much you want a cigarette. Ask yourself how do you feel about going back to your old level of consumption. Smoking is an all or nothing proposition.
- Save the money you usually spend on cigarettes and buy yourself something you really want after a week or a month. Save for a year and you can treat yourself to a vacation.
- Practice deep breathing exercises when you have a craving.
- Go places where you normally can't smoke, such as movies, libraries and no smoking sections of restaurants.
- Tell people around you that you have quit smoking.
- Remember that there are only two good reasons to take a puff once you quit. You decide you want to go back to your old level of consumption until smoking cripples and then kills you, or, you decide you really enjoy withdrawal and you want to make it last forever. As long as neither of these options appeal to you - NEVER TAKE ANOTHER PUFF!
© Joel Spitzer 1987