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Francis Ray: The life, work of a best-selling author
QIANA JONES | 8/5/2013, 1:15 p.m.
In December 1991, Francis Radford Ray was a promising writer wanting to be published. At the same time, Leticia Peoples was also an up-and-coming writer wanting to be published, but neither could find a publisher. Peoples then launched Odyssey Press, an African American small press in Maryland and signed Radford as her first writer. This began the flourishing career of a New York Times and U.S.A Today best-selling author.
The youngest of five children, she was born as Francis Radford on July 20, 1944, in Richland, Texas. After graduating from Corsicana High School, as part of the second class of African American graduates, she earned a Bachelor of Science degree in nursing from Texas Woman's University.
In 1967, she married William Henry Ray. The two had one child, Michelle.
Affectionately called "Nurse Ray" by teachers and students, she served as a pediatric nurse practitioner in the Dallas Independent School District for over 40 years. Alongside her practice in the school district, she authored over 50 books. Her first book, Fallen Angel, was published in 1991 by Odyssey Press. After the press closed, she was one of the first authors to be published as part of Kensington Publishing's African American imprint, Arabesque. During that time, she wrote Sarah's Miracle, which was adapted into a stage play, and Incognito, which was developed into a movie in 1999.
In 1995, Ray partnered with Emma Rodgers, former Black Images Book Bazaar owner, and her business partner, Ashira Tosihwe, to create Romance Slam Jam. It began in Dallas as a small, evening social event to connect African American romance readers and writers, but soon blossomed into one of the largest genre specific African American conferences.
"It's gone from seven authors and 25 readers, in half of the day to something that extends over three days with over 700 people coming from all over," Osborne said. The next Romance Slam Jam Conference will be held in New Orleans, La., from May 7 to May 11. "They will pay tribute to Francis, not just for her work, but as a founding member. It's an opportunity to be honored by her own."
Gwendolyn Osborne, senior reviewer at The Romance Reader and associate editor for Black Issues Book Review, has reviewed Ray's work professionally and said she has read her work personally for pleasure.
"She was into families, personally and as an author," Osborne said. "She was a nurse. She was a healer. Her books had that impact."
In fact, she established the Turning Point Legal Fund after writing her 2001 book, The Turning Point. As she researched the issue of domestic violence, she was moved to create the fund to assist women who are victims of domestic violence with their legal expenses. The fund is managed by The Family Place, a women's and children's shelter.
Ray's work consistently made The New York Times bestseller list during her writing career as well as the Blackboard, Black Expressions Book Club and Essence bestsellers list. She is the recipient of many awards such as Borders 2008 Bestselling Multicultural Romance Award for Nobody but You, Written's 2010 Readers Choice Book of the Year for If You Were My Man, the EMMA award, and Romantic Times' 2008 Reviewers' Choice Award for Not Even if You Begged.


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The federal drug enforcement agency is looking into records pertaining to the distribution of prescription drugs handed out to players by trainers and doctors, the source added.
Those records would include documented visits and examinations by doctors, diagnoses and authorized prescriptions written for players. The investigation is described as being in its "early stages."
The DEA would not respond Monday to inquiries specifically on the NFL.
Agency spokeswoman Erin Mulvey in New York told CNN, "We cannot confirm or deny the existence of any investigation."
Depending on what is found, the case could become a civil and/or criminal case with doctors potentially going to jail if convicted of drug-related offenses.
In part, the investigation was prompted by a class-action lawsuit filed in May, 2013 in federal court by nine named retired NFL players representing 1,300 others who claim the NFL "intentionally, recklessly, and negligently created and maintained a culture of drug misuse, substituting players' health for profit," according to court documents.
The players' suit accuses NFL trainers of handing out pills without prescriptions and without regard to possible dangerous interactions with other drugs.
The named players in the lawsuit include former Chicago Bears quarterback Jim McMahon who, according to the lawsuit, says he got hooked on painkillers taking as many as 100 Percocet pills a month.
"Our more than 1300 clients welcome any government investigation which aims to protect them from further harm," Steve Silverman, attorney for the plaintiffs suing the NFL, said in a statement to CNN.
NFL Senior Vice President of Communications Greg Aiello said in a statement Monday that "we are unaware of any such investigation."
It's unclear at this point whether subpoenas have been prepared during this phase of the investigation.
The story was originally reported by the New York Daily News.
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subset: commoncrawl


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Since I haven't worked in a bakery, or have done any cake decorating since I graduated school, I decided it was time to practice my piping skills again. So, I made some cupcakes to give me a nice "canvas" for my decorating skills.
I only had a large pastry bag, so I was only able to use the star tip and the bigger size of the straight tip that I have, but still, some practice is better than none. I used a combination of the "shell" design and the "pearl" design for these cupcakes.
Next time, I will have another bag that I can use with my smaller tips, and I will practice making buttercream roses, and other flowers. I will also get some food coloring, so there will be no boring, really ugly, brownish chocolate frosting.
Also, now that I have a piping bag, I can make other desserts that require piping, such as eclairs, and macaroons. I also just bought some new cake and tart pans that I can't wait to try!


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Talia Skincare: Buy Natural Beauty Products Online Are you looking at options for natural beauty products online? Talia Skincare is known for natural skin care products that leverage the power of the Dead Sea, active botanicals, nourishing natural ingredients that are cruelty-free. We are also known for our unwavering commitment to natural beauty and skin care that you can feel great about. At Talia Skincare, we offer some of the best luxury skin care products you can find, including the best winter skin care products as well as products for the other seasons your skin must contend with.
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I've said it three times in the above paragraph, hopefully it sinks in.
The other aspect to it is that as the most set batsman, getting out for a middling score like 50-70 is a huge fillip to the bowling side, and exposes the team further than what losing the newer batsman up the other end does. You have a greater responsibility once you are the set batsman, and Watson in particular throws that away regularly.


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Modify WordPress Plugin Shashin Default Thumbnail Size
I have been using the Shashin WordPress plugin for awhile now to display my Google Picasa image galleries. This plugin basically generates pages on your site that embed the images from your Picasa image galleries. So far I have been really satisfied with the plugin and tried numerous other Picasa plugins before settling on this one. One thing I needed to change because of the layout of my site was the default size for the album thumbnails which is 160 pixels. Below I describe how to modify this size so you can display more albums in a smaller amount of space.


text: « Return to Search Tessa Hadlock, M.D., Appointed Director of the Division of Facial Plastic and Reconstructive Surgery at Massachusetts Eye and Ear December 21, 2011 Contact: Vannessa Carrington Ph.: 617-573-3341 Boston — (Dec. 21, 2011) — Tessa Hadlock, M.D., a resident of Concord, Mass., has been appointed Director of the Division of Facial Plastic and Reconstructive Surgery at Massachusetts Eye and Ear Infirmary. The Division includes the Facial and Cosmetic Surgery Center, dedicated to anti-aging and reconstruction, and the aesthetic and functional enhancement of the head and neck. The Division also includes the Facial Nerve Center, which provides the experience and expertise of a team of medical specialists skilled in the evaluation and treatment of facial nerve disorders, in addition to specialized testing, equipment and treatment. Dr. Hadlock is an Associate Professor of Otology and Laryngology at Harvard Medical School. She is a graduate of Harvard Medical School and the Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology. She completed her surgical residency in otolaryngology/head and neck surgery, and a surgical fellowship in facial plastic and reconstructive surgery, both at Mass. Eye and Ear. For the past 10 years, Dr. Hadlock held the position of Director of the Facial Nerve Center at Mass. Eye and Ear. She will continue to lead that Center in addition to her new position. Dr. Hadlock, who also completed a research fellowship at Mass. Eye and Ear and Children's Hospital, is the author of numerous published articles and book chapters in her specialty. She is a member of the American Academy of Otolaryngology/Head and Neck Surgery and the American Academy of Facial Plastic and Reconstructive Surgery. She is also active in helping patients all over the world through medical missions and teaching physicians while on these missions so they can better care for those who need them. About Mass. Eye and Ear Founded in 1824, Massachusetts Eye and Ear Infirmary is an independent specialty hospital providing patient care for disorders of the eye, ear, nose, throat, head and neck. Mass. Eye and Ear is an international leader in Ophthalmology and Otolaryngology research and a teaching partner of Harvard Medical School. Under the direction of Mass. Eye and Ear's board of directors, the Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute recently formed the world's largest and most robust private basic and clinical ophthalmology research enterprise. For more information, call 617-523-7900 or visit http://www.masseyeandear.org/.


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Hail is a form of precipitation which is recognized by large solid balls or clumps of ice. Hail is created by thunderstorm clouds with strong updrafts of wind. As the hailstones remain in the updraft, ice is deposited onto them until their weight becomes heavy enough for them to fall to the earth's surface.
Hail storms can cause significant damage to crops, aircrafts, and man-made structures, despite the fact that the duration is usually less than ten minutes.
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Rain is the most common form of precipitation and happens with greater frequency depending on the season and regional influences. Cities have been shown to have an observable effect on rainfall, due to an effect called the urban heat island. Compared to upwind, monthly rainfall between twenty and forty miles downwind of cities is 30% greater.
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Courtesy of Springfield College Sports Information
SPRINGFIELD, Mass. – Despite a furious second-half rally, the MIT men's soccer team held on for a 2-1 victory over Springfield College in the New England Women's and Men's Athletic Conference (NEWMAC) opener for both teams on Brock-Affleck Field on Saturday afternoon.
The Engineers (6-2, 1-0 NEWMAC) jumped on the board first in the 22nd minute as their constant offensive pressure to start the contest finally paid off. On his sixth corner kick of the opening 20 minutes of play, Christian Therkelsen sent a dangerous bending ball into the box. Ben Lewis used every inch of his 6-4 frame to rise above the Pride defense to head home the MIT's first tally into left corner of the net.
The Cardinal and Gray added to its lead as it struck 11 minutes into the second half. Matthew Monheit broke free inside the 18 and let loose a shot that Springfield goalie Chris Walton deflected away. However, Monheit followed up his shot and slipped home the rebound to give the visitors a 2-0 edge.
Springfield (4-2, 0-1 NEWMAC) finally found the back of the net in the 65th minute on Ryan Malone's third goal of the season. After Jae Tracey was fouled outside of the box, Malone calmly tucked home a free kick from 25 yards out just inside the right post to make it a 2-1 contest.
The Pride continued to push forward as Malone had a pair of promising chances late in the second half, but neither attempt materialized into a Springfield goal.
For the contest MIT owned a 16-12 advantage in shots and took eight corner kicks, while the Pride earned just four. Walton posted seven saves in the loss, while Dylan Rankin earned the win as he made three saves.


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Numerous therapeutic HIV vaccine studies have taken place over the years. Though, none have produced impressive results, there continues to be interest in this type of approach. Theoretically, a therapeutic vaccine might offer the potential for a monthly injection with few side effects as a way to treat HIV, prevent or delay the need for anti-HIV medications and/or allow for prolonged periods of time off of anti-HIV medications. This potential is what keeps research in this area going despite disappointing study results.
The goal of a therapeutic vaccine is to bolster immune responses against HIV in hopes of boosting the body's ability to control HIV replication. For most people, natural immune responses against HIV are not enough to control HIV disease for the long-term. It is hoped that by boosting immune responses artificially that HIV disease progression could be prevented or significantly delayed.
Who Participates in Therapeutic HIV Vaccine Studies?
Studies of therapeutic vaccines focus on people with HIV who are healthy with relatively intact immune systems. Most studies have included people with CD4+ cell counts above 250 at study entry. Many studies require people to have even higher CD4+ cell counts at study entry, above 300 or 500, and also require that a person never had a CD4+ cell count below 250. Most studies of therapeutic HIV vaccines will require people to take anti-HIV medications while they are receiving the experimental vaccine.
People with lower CD4+ cell counts are generally not included in studies of therapeutic HIV vaccines because the effectiveness of a vaccine is dependent on immune function. If a person has poor immune status, vaccines are unable to induce new immune responses or bolster existing responses. Thus, therapeutic HIV vaccines will likely never prove useful for people with advanced-stage HIV disease and low CD4+ cell counts.
Many therapeutic HIV vaccine studies currently ongoing include some period of time off all therapy. Taking people off all therapy after they have received a therapeutic HIV vaccine might show if the new immune responses are able to prevent HIV from reproducing without the help of anti-HIV medicines.
Are There Side Effects of Therapeutic HIV Vaccines?
Each product will carry its own unique risk of side effects. In general, however, side effects associated with experimental therapeutic HIV vaccines have been similar to side effects of commonly available vaccines. That is redness, swelling and/or pain at the site of the injection and sometimes mild flu-like symptoms.
Side effects could be more serious than mild pain or flu symptoms, however. They could include more severe pain and/or ulceration at the site of injection.
If the vaccine was made out of whole-killed or live-crippled HIV, it's possible that the virus in the vaccine could combine with a person's HIV and potentially become infectious. One therapeutic vaccine, HIV-Immunogen (Remune), is a whole-crippled form of HIV. In studies to date there is no evidence that it worsened anyone's HIV infection. There is also no evidence to date, however, that it has benefited anyone.
Are There Other Risks of Participating in a Therapeutic Vaccine Study?
It is possible that an experimental therapeutic HIV vaccine could stimulate HIV replication and increase the risk of HIV disease progression. Vaccination stimulates and activates the immune system and this has been associated with increases in HIV replication. Also, immune responses brought about by vaccination could possibly enhance the ability of HIV to infect cells.
It is possible that people who receive an experimental therapeutic HIV vaccine that doesn't work will not benefit from an effective therapeutic HIV vaccine. It is very likely that people who participate in a study of a therapeutic HIV vaccine and receive the experimental vaccine (rather than the placebo) will not be eligible to participate in studies of other therapeutic HIV vaccines and other experimental anti-HIV and immune-based approaches.
Are There Possible Benefits to Participating in These Studies?
It is possible, by participating in an experimental therapeutic HIV vaccine study, that the vaccine will be effective in slowing or preventing HIV disease progression. People who received the vaccine (rather than the placebo) will have gained earlier access to an effective therapy.
Ultimately the decision to participate in an experimental drug study is a very personal decision. Products tested so far have had relatively few side effects, but results from studies aren't very encouraging. New products that boost the immune system differently and/or more potently are constantly entering small studies. Currently most (if not all) studies of therapeutic vaccines require that people be on anti-HIV therapy, and most studies include some period of time off all therapy following vaccination.


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The Cape Coral Planning and Zoning Commission is expected to vote Wednesday on whether to recommend allowing a church to erect a stage and other features on site.
Cape Christian Fellowship is asking for an amendment to its planned development project, including a special exemption that would allow for a "religious facility" in an area zoned now as single-family residential.
It has proposed building a covered sound stage, youth recreation area, food services building and covered pavilions and needs the exemption to do so.
Proposed Ordinance 21-13 also allows for the use of synthetic turf behind the stage and grants approval of the church's master development plan.
The ordinance will go before the P&Z at 9 a.m. in the council chambers at City Hall, at 1015 Cultural Park Blvd.
The meeting is open to the public.
Derek Burr, planning manager for the city's Department of Community Development, explained that this is the first vote on the amendment.
"It's never been before planning and zoning," she said Friday.
"It's never been rejected," Burr added.
City staff supports P&Z approval of the ordinance, with conditions.
The church plans to construct a 3,000-square-foot stage about 80 feet west of Chiquita Boulevard South, facing northwest, according to a report. Staff recommended that one condition be limiting the hours of operation.
"Limitations on when they can use the sound stage," she said.
The suggested hours are Sunday through Thursday from 10 a.m. to 8 p.m. and Friday and Saturday from 10 a.m. to 10 p.m., the report states.
Another recommended condition is that the church abide by the city's existing noise control ordinance. Burr explained that the church submitted a sound study with its application to indicate the expected decimal levels.
"It is being designed so that the noise does not disrupt the neighborhood," she said.
City staff cited increased traffic as another potential impact to the area from the church's proposed plan. City policy requires that a "special event" permit be obtained for events anticipated to attract 500 people or more.
Staff recommended the condition that the church be limited to 15 special event permits per year and no more than two special events per month.
The permit also covers the use of police assistance to ensure traffic safety, security if needed and off-site parking areas that are approved by the city.
"That's all part of the requirements," Burr said.
City staff also recommended a condition regarding lighting levels.
"So you won't have any light bleeding over into the residential," she said.
Some nearby residents have voiced concern about the proposed plan.
William and Suzette Tirelli, of 2120 S.W. 17th Ave., live directly behind the church. They and another couple in the neighborhood circulated petitions last year to try and stop the building of what was being called an amphitheater.
"Our main concern is the amplified music in the homes - that we are going to lose our quality of life," Suzette Tirelli said Friday.
She noted the direction of the stage and how the sound will carry.
"The amphitheater is 200 feet from our home, and they're trying to say that we're not going to hear it," Tirelli said.
"Not only are you going to have the amplified music, you're going to have crowds, you're going to have cars coming into the area," her husband said.
Bill Tirelli pointed out that during a recent concert at the church, the music could easily be heard from their driveway - without the stage.
"It's going to be louder," he said.
According to the couple, people moved to the Cape for a reason.
"They came down here for quality of life," Tirelli said, adding that the construction of the stage will lower home values in his neighborhood.
"No one's going to want to buy a home," he said. "That's just not fair to the taxpaying homeowners that are in this area."
Tirelli compared approving the ordinance to opening a can of worms.
"If they get it here, what's to stop other churches in the area or other groups that have a large chunk of land from putting in an amphitheater?" he asked. "Once it's open, it puts other people in the same situation."
Burr acknowledged that staff is aware of complaints by some residents, and that there is always concerns with projects but they try to address them.
"We can just provide the best recommendations that we can provide," she said. "Being a pre-platted city, it's very hard to locate non-residential uses in the city."
The grounds - called Fellowship Park - will be open to the public.
"They did ask for some changes to what we recommended," Burr added of the church. "But we are going forward with out recommendation as is."
The church wanted to use the sound stage later on the weekends.
"They were concerned about the hours of operation," Burr said. "We were not agreeable to that."
P&Z can make changes to the ordinance before voting on it.
"And then city council, of course, has that same options," she said.
The ordinance is tentatively set to go before council on April 19.
Cape Christian Fellowship is at 2110 Chiquita Blvd. S.


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- RT @: Even in east Boulder County, there are damaged bridges, culverts and roads. Please stay inside.
- RT @: Images of Peraud crashing, falling on same collarbone he broke earlier today are so, so disturbing. My right clavicle throb…
- Per BCSO, tacks found on the road at Lee Hill and Olde Stage Road. Be careful out there! Cc @
- First weekend of racing out of the way. Spent most of the time in the break and helped setup @ for a pair of podiums!
- Made it up to Peak to Peak for the first time this season. It went well despite not having a jacket or hat...
Blog Post Calendar
December 2013 M T W T F S S « Dec 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31
- Windy solo endurance ride: 2h:55m, 209w avg, 224NP, 2167kJ, 146TSS. Avg power exactly middle of Z2, based on winter estimated LT of 315w.
- 2h Z2 with 10 x 10 pedal stroke "a-lactic" sprints. Minimal HR drift (2.5%). Totals: 2h:5m, 39.5 mi, 1700kJ, 225w avg, 249NP.
- @ Sorry for the late reply. Only very hard days. About once a week or less.
- Another base ride: 2h, 222NP (208 avg). 1400 kJ. 93 TSS. First ride on the road bike in 3 months!
- I'm Back! First workout of 2013 season. Ouch. Need to reset zones. Bulk of w/o Z2/200w avg / 224NP for 2h:15m. Total: 3h:8m, 2000kJ, 140TSS.
- Yesterday off. Today 3h:30m MTB ride for 'fun'. 5200' vertical in only 33 miles. Dirt was fun though.
- 30 minutes core / strength (body weight only for now) and 15 minutes on the rollers.
- Day off.
- Fun ride on the Cross bike. 4h, 61 miles, 2600 kJ, 175 TSS. 'Easy' at 226 NP and 187 avg. Some 'secret' trails:
- 5k fun run/jog/walk with the whole family and later a 1 hour walk. I think I ate enough to count as a workout, but how to figure TSS...?
Tag Archives: plans
2012 Data in Review
Every season presents unique challenges. 2012 was an interesting year for me. I was coming off a significant injury with a broken collarbone in October 2011. I started a new job in January, and was presented new challenges finding time … Continue reading
Posted in Equipment, Personal, Training Tagged cycling, data, goals, peak power, plans, power, power analysis, power meter, racing, training 5 Comments


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The Intermediate Citizenship Class lasts 12 weeks. Students develop a foundation in the 100 civics questions in the citizenship exam, as well as learning to read, recognize and write the vocabulary required in the reading and dictation portions of the citizenship interview.
Two classes are available on Saturdays: one in the citizenship classroom and the other on the third floor.
- July 01, 2015 at 6pm – 8:30pm
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Los Angeles, CA 90005
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Alberto Patricio
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Carmen J DeMarco
29, Leo
Lives: Fells Point
Hometown: Newfield, N.J.
Education: University of Southern Mississippi
OCCUPATION: Manager, Bond Street Social
INTERESTS: Sports, hanging out with friends, relaxing on a beach during the day and dancing my face off at night
TURN-ONS: A girl who is not afraid to sweat in front of me, one who looks good with her hair pulled back in a ponytail, tight T-shirt and jeans. I also love when a girl isn't afraid to rock out in the car with me and
TURNOFFS: Drug users, smokers, obnoxious drunks and bad kissers
IDEAL DATE: A day at the beach relaxing, cooking dinner for my date, drinks and dancing till the end of the night
BEST TRAITS: Solid cook, love to dance, very personable
WORST TRAITS: Late sleeper, awkward at times, and I am nice to a fault.
ROLE MODEL: My mother, such a strong woman. I cannot say enough about her to say anything at all.
FAVORITE QUOTE: "Every now and again, sometime I get lost on the wind of a dream. The rope gets loose, the chains unbind, and I can do anything." — "Anything" by -mae
FAVORITE DRINK: Ketel One and soda with lime
BEST MOVIE EVER: "Empire Records"
BEST SONG RIGHT NOW: "Cinema," Benny Benassi. Skrillex remix is better then the original, though.
BEST DECADE FOR MUSIC: I'm a huge '90s rock fan
CLEAN LIVING OR VICES: Clean living, although I tend to throw my clothes everywhere
SHOP OR SAVE: Mixture of both; like saving to shop
OPTIMIST OR REALIST: I try to look at the bright side of things, but I guess when it all comes down to it I'm a realist.
WORKOUT OR WORKAHOLIC: Workaholic. I love to work out, but it's a distant second to working.
LIBERAL, MODERATE OR CONSERVATIVE: Moderate. I see the points both parties make and can deal with either side.
UP AT DAWN OR UP AT NIGHT: Up at night. In this industry, I don't know how anyone could differ.
CLUBS, BARS, BLACK-TIE EVENTS OR HOMEBODY: It really depends on the mood I'm in and the poeple I'm spending that time with.
CUDDLER OR NEED SPACE: Again, I'm a little bit of both. I'm not a PDA type of person, so behind closed doors I will cuddle with the best of them.
DANCER OR SPECTATOR: I enjoy both but would rather participate
SPORTS, ARTS OR BOTH: I enjoy both, but if Ihad to choose 10 times, it would be sports nine times out of 10.
OUTGOING OR SHY: A little bit of both. Sometimes females are a little intimidating. But not that often.
ROM-COM OR ACTION THRILLER: Comedies, hands down winner. Who doesn't love to laugh?
FASHION SENSE — BIG DEAL OR WHO CARES: Big deal! You have to be well put-together these days. But to each his own. Never knock another person's style ... just rock your own.
MARRIAGE & KIDS — SOONER, LATER OR NEVER: Sure, when the time is right. I'm not trying rush anything, though.
FAVORITE ARTICLE IN LAST WEEK'S B: Free & Clear, the story of Orioles pitcher Alfredo Simon. I'm a huge baseball fan, and I just thought it was an interesting story of how he finally made it to where he is today with the Orioles.
HEIDNSEEK EVENT YOU CAN FIND ME AT: Working at Bond Street Soical for the monthly networking event.
Nastassia "Nikki" Cornett
24, Libra
Lives: Baltimore
HOMETOWN: Baltimore
Education: CCBC Essex
OCCUPATION: Restaurant Manager at RA Sushi
INTERESTS: Music, traveling, food!
TURN-ONS: Determination, wittiness and tattoos
TURNOFFS: Dirty fingernails, bad eating habits, blowouts
IDEAL DATE: Something that allows us to open up and laugh. Take me to a comedy show!
BEST TRAITS: My sense of humor, an open mind and my luscious locks
WORST TRAITS: Clumsiness, talking fast and indecisiveness
ROLE MODEL: My Aunt Tina
FAVORITE QUOTE: "Not all who wander are lost."
FAVORITE DRINK: Mark West Pinot noir!
BEST MOVIE EVER: "Million Dollar Baby"
BEST SONG RIGHT NOW: "Free Bird," on constant replay
BEST DECADE FOR MUSIC: The music being created in our decade now has been pretty epic.
BOOK I'VE READ MORE THAN ONCE: I read a lot, but not enough to read anything twice.
CLEAN LIVING OR VICES: Depends on the week for me. Remember, I'm indecisive.
SHOP OR SAVE: Shop
OPTIMIST OR REALIST: Realist
WORKOUT OR WORKAHOLIC: I work out while I work. RA keeps me in shape.
LIBERAL, MODERATE OR CONSERVATIVE: Moderate
UP AT DAWN OR UP AT NIGHT: Up at night
CLUBS, BARS, BLACK-TIE EVENTS OR HOMEBODY: All of the above, please?
CUDDLER OR NEED SPACE: Space
DANCER OR SPECTATOR: Spectate before you dance!
SPORTS, ARTS OR BOTH: Arts
OUTGOING OR SHY: Outgoing
ROM-COM OR ACTION THRILLER: Action thriller
FASHION SENSE: BIG DEAL OR WHO CARES: Big deal
MARRIAGE & KIDS: SOONER, LATER, OR NEVER: Later … much later.
FAVORITE ARTICLE IN LAST WEEK'S B: the "different and delectable" I manage a restaurant; I obviously love food. Most of the places listed on there I had been dying to try. It gave me a little more insight about some specific places. Honey Pig, definitely going there!
HEIDNSEEK EVENT YOU CAN FIND ME AT: Friday nights at The Get Down. I love this venue!
Interested? Email firstname.lastname@example.com with Carmen or Nikki as the subject.
Want to be featured? Send your photo and the answers to the questions above to firstname.lastname@example.com


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Dear Diary, I mean readers - so much has happened since I last wrote; I'm going to have to break this beefy column down into manageable meatballs so you don't get confused.
First thing: Elliot's birthday at Monkey Joe's fell between a shared six-pack with Joe Biden and an episode of "Wipe Out."
Of course, we weren't drinking alcohol at the party, but the unpredictability of the situation was just shy of exhilarating. Kids who RSVPed showed up, and the others didn't.
My friend, Matt, missed the Packers pre-game show to bring his son (a fact Elliot will appreciate later in life), and it was a little interesting to learn that another parent in law enforcement was actually packing. While the kids were playing, he taught me how to disarm and break a gun-toting assailant's fingers.
We were going to get into the Israeli fighting method known as Krav Maga, but there wasn't time what with the 3-year-olds demanding slices of pirate cake and juice boxes.
Elliot refused to sit on the giant, inflatable birthday boy throne for even one photo, and that felt a little like being shanked in prison. But what are you going to do - force the kid to sit there at gunpoint (or bribe a cop to do it for you)? No, of course not.
During the two weeks between Elliot's birthday and Christmas, we enforced Claus Law. Every step that our son took out of line was met with a firm reminder of what St. Nick would have him do. It worked for a while. Elliot's used to being told at day care that, should he misbehave, he'll be sent to Ms. Thacker's office. She's a sweet lady, but it must work. He understands the weight of the threat, and here's the proof.
My mom and aunt show up to spend Christmas with us, and Elliot starts to get mouthy. He tells my aunt, "Go! Shoo! Go away!" and his nanna faces equal yelling and brattiness. We counter by evoking the man in red. "Do you want Santa Claus to skip our house?" He continues his swatting and fussing over the course of a few days, and time-outs add up. It's terrible to watch him mouth off at relatives he sees a few times a year, but then he starts turning the tables on all of us.
When any one of us disciplined Elliot, he'd say, "I'm telling Thacker and Santa Claus!" Then he'd flip open an imaginary cellphone and begin a list of our combined offenses. While he was asleep, I grabbed his imaginary phone and flushed it down an imaginary toilet, and then I opened an imaginary bottle of Goldschlager and started drinking it through a straw.
It was right after this that I learned that Charles Durning had died. When my older sister found me, I was alone in my office watching clips of him on YouTube. I'd purposely dug one up from the movie Tootsie and was singing "It Might Be You" by Stephen Bishop. Then there was this weird emotional snag where I mourned a life unlived, one where I am a soap star and Dustin Hoffman confesses his love for me on a busy New York street.
"The timer on your rib roast is about to go off," she said. It was just as well. I was about to skid into Olivia Newton-John's "Magic," and that would pave the way for Sheena Easton's apocalyptic "Morning Train" and Gregory Abbott's soul-stirring "Shake You Down."
Elliot went to bed on Christmas Eve not fully understanding what would happen the next morning. Santa would surely bring him the bike, tractors and trucks on his list, but it was the same bedtime routine as any other night. Oddly enough, Christmas was also the same morning drill. From the depths of holiday slumber I hear, "Mama! I got poo-poo!" I stubbed my toe on the leg of the bed and said to my husband, "Get up, hon; it's Christmas."
By the middle of the day, Elliot was riding his two-wheel Lightning McQueen bike at the park. A small cheering section encouraged him to keep trying, take the occasional fall in stride, and pedal right through frustration until the bliss of momentum arrives. He did, and the wise man beside him kept a socket wrench in hand for those minor adjustments that make for a more comfortable ride.
Christmas is a year away again. Claus Law has melted, but thankfully, we've still got Thacker.
Christine Lucas writes about being a first-time mom and adventures with baby. Contact Christine at firstname.lastname@example.com.


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Under normal circumstances, antibodies recognize things that (in molecular terms) are big, like parts of bacteria and viruses that invade our bodies. That's largely because of the way that antibodies are selected for during an immune response. But by playing a bit of a trick on the immune system, it's possible to generate antibodies that attach to smaller molecules, ones that contain only a few dozen atoms. This has been used to do things like create antibodies that act like catalysts for chemical reactions.
The ability to create antibodies that specifically bind to small molecules has raised hopes that they'll prove useful for a very challenging medical problem, namely drug addiction. Antibodies that latch on to drugs could keep them away from their sites of action in the brain, blocking any rewarding high. So far, the results haven't been as promising as the idea, but a new vaccine against heroin appears to do better specifically because it's designed to work with how the drug is processed by the body.
The immune system is able to produce many antibodies that recognize the pathogens it is currently facing for a simple reason: antibody-producing cells can sense when their antibodies are sticking to something. This process works because these cells stick a lot of antibodies on their surface. When they stick to an invader like a virus, it creates a cluster of antibodies in the same area on the cell's surface, all of them stuck to a single virus. This clustering is enough to trigger a signal that tells the cell that its antibody is working.
Small molecules can't do that. Since they're small, only one antibody can stick to them at a time, so there's no clustering, and the cells that produce the relevant antibody remain quiet. (Immunologists, please forgive me for the simplifications I made there.)
The trick to avoiding this is to link lots of the same molecule to the surface of a big protein. Multiple molecules linked to the same protein get recognized by antibodies, which now cluster as a result. A lot of antibodies get made.
Researchers who tried this process with heroin, shown above, tended to hook it up so that the complex, three-dimensional part of the structure that's off on the right was accessible. Since it's chemically distinctive, it should be easy to generate antibodies that are specific to it. So researchers hooked up the heroin to a protein using one of the sites at left, where two CH3's hang off the molecule (these, plus the neighboring oxygens, constitute an "acetyl group"). The antibodies were generated; it's just that they weren't especially effective. A slight increase in the dose of heroin, and the antibodies were swamped.
Looking at the biology of heroin, however, a team from the Scripps Institute figured out they were going about it wrong. Normally, in a matter of minutes, the body starts removing the two acetyl groups anyway. When both are gone, the result is morphine, which is the active form of the drug. It's thought that the full heroin molecule crosses into the brain before being converted into morphine.
The researchers hooked the drug up to a protein using a bond near the three-dimensional part, keeping both of the acetyl groups accessible. In their terminology, the vaccine was "dynamic" in that it would undergo all the chemical transformations that heroin does, allowing antibodies to be generated to each of the intermediate molecules.
This approach seemed to do the trick. By various assays, it appears that more of the heroin is retained in the blood rather than transiting into the brain. Rats needed a much higher dose of heroin—over six times higher—to feel its pain-numbing effects, and antibodies generated to morphine alone were much less effective.
The most intriguing test, however, involved rats that had been allowed to self-dose with heroin, which was accompanied by a blinking light. After an extended withdrawal, the rats would go right back to self-medicating if they were given a single dose of heroin or shown the blinking light. Once they were treated to raise the dynamic antibodies, however, the dose of heroin would no longer set off a bout of drug-taking (though the blinking light still would). The antibodies appeared to block the drug efficiently enough that it no longer registered in the brains of these rats.
This isn't an easy or simple solution. Vaccinating the rats required three doses within a month, and the rats still could get a hit off the drug—it just took a lot more of it. In human societies, addicts requiring a lot more of a drug can be a recipe for serious problems. But for those enrolled in supervised treatment programs, it could make a significant difference in keeping a momentary lapse from becoming a full relapse.
PNAS, 2013. DOI: 10.1073/pnas.1219159110 (About DOIs).


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Ringworm, unknown to many is not a worm or a parasite; it is instead a contagious fungal skin infection. Read on to know more about what does ringworm look like and what are its symptoms and available treatments are.
What Is Ringworm?
Ringworm is a microscopic fungus that infects only the outer layer of the skin. Ringworm does not go deep into the body as it cannot live on mucous membranes in the vagina or the mouth.
Ringworm thrives on moist and hot parts of the skin and more so into those areas that remain hidden from direct light. To know what does ringworm look like you can log on to the various sites that show pictures of patients of people affected with this skin infection.
Here is a brief insight into what does ringworm looks like:
■ Ringworm occurs as round or oval red scaly patches on the skin. The color of the patches can vary from being pink to deep red.
■ The patches have a scaly border and are less red and scaly in the middle. They at times also have a healed look in the middle.
■ The edge of the ring is lifted due to the fungus. This part is the reddest and most scaly part of the patch.
■ This part also contains the pus and the fluid. It besides being moist can also be dry, crusted and scaly.
■ The lesion starts to heal from the center to outwards. At times the person would also experience another ring arise inside the previous one.
■ The fungus comes up as a coin-sized ring that is about one and a half to one inch in diameter.
■ People who have been hit hard by the skin infection often complain of extreme itchiness and irritation.
■ Once a person gets attacked by the fungus he would soon notice several patches of ringworm on his skin all in one go.
Cure For Ringworm
One who is inflicted with the infection must ensure that he does not scratch the lesions because if he does so then the infection would spread at an even faster pace. The condition can easily be treated with over-the-counter anti-fungal creams. Another common treatment is using tea tree oil which is a natural anti-fungal antiseptic on the patches. Ringworm on the scalp and the face would require anti-fungal shampoos and even oral medication.
You can always understand the symptoms better by seeing some pictures of patients who are afflicted by this condition. This would help you know exactly what does ringworm look like.


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Call 1-800-922-5484
Home > Photography > Traditional Black-and-White Films > Ilford Black & White Films > Ilford 2019 Ultra Large Format (ULF) Film Program > Ilford 2019 ULF Program HP5+ 400 Film > Ilford HP5+ 400 ULF Program 5" x 12" / 25 Sheet Film
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Place your order now through May 24th, 2019. Orders will ship in September/October.
Ilford HP5+ 400 ULF Program 5" x 12" / 25 Sheet Film
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The official Hampton Wick Royal Cricket Club app
Bushy Park Hampton Wick Kingston Upon Thames Surrey KT1 4AZ View with Google Maps
This website is part of the Pitchero Cricket network. Create your own free Cricket club website with Pitchero.
Digital advertising by Minute Media
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Pitch Hero Ltd Registered in ENGLAND | WF3 1DR | Company Number - 636 1033


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Joint pain and Taxol reaction
Dear OncoLink "Ask The Experts,"
I have recently finished treatment for male breast cancer, including a mastectomy with removal of some lymph nodes and 6 months of chemo with A/C and Taxol. Now, 2 months after very difficult treatment I am experiencing easy bruising all over my body, joint pain and swelling, and loss of strength in the hand of the effected side of my body. Is there a relationship between these symptoms and the chemo regime, and will it improve? As a Toolmaker I work with my hands for a living and am currently incapacitated by this new development. . Is there anything I can do or a course to pursue to alleviate the pain and/or reverse this new problem?
Kevin R. Fox, MD, Assistant Director, Clinical Affairs and Associate Professor of Hematology/Oncology at the Abramson Cancer Center of the University of Pennsylvania, responds:
Some patients that receive cancer treatment may have a variety of complaints even after the full treatment course is completed. The symptoms you are complaining about are common and are most likely related to the Taxol chemotherapy. It can sometimes take months for these symptoms to improve and resolve. In my experience, it will almost certainly get better. You should discuss these complaints directly with your physician to make sure that there are not any other potential causes of these symptoms related to your individual situation.


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The Lincolns first home in Illinois
Decatur site gets new study and a makeover
When Abraham Lincoln, his father, stepmother, and step-brother first came to Illinois from Indiana, they settled in a log cabin about three miles west of Decatur on the Sangamon River. The history of that long-gone cabin is a tangle of folklore and interesting facts.
The city of Decatur, through its Lincoln Heritage Project, commissioned a makeover and study of the cabin site, located in the state-owned Lincoln Memorial Homestead Park. So, for the first time, experts are unraveling the cabin's true story, which ends in mystery.
"The Lincolns came to Illinois in March 1830 with a group of about 13 extended
family members," says Kim Bauer, director of the Lincoln Heritage Project. The Lincolns came
because John Hanks, Abraham's second cousin and "one of his favorite relations of all time," moved there earlier and wrote Abraham's father proclaiming the area's cheap, plentiful, fruitful land, Bauer says. "Hanks made (Illinois) sound so good that eventually Thomas (Abraham's father) determined he wanted to move."
Because the previous winter had been very wet, their trip here was slowed by the
copious mud. "They stayed the night at the square in Decatur…at that time it was a little village of a few dozen huts and cabins," Bauer says. "Illinois was still a frontier."
It took 21-year-old Abe, his father, his step-brother, and cousins John and Dennis Hanks about four days to construct the cabin. They may also have built a smokehouse and outbuilding, but that's uncertain. "They broke about 10 acres of sod and planted 'sod corn,' and (Abraham) helped cut those famous split rails they used to encircle the ground," Bauer says.
Then they got sick — really sick. The whole family came down with "ague," or fever, chills and shakes, often caused by malaria.
"Some accounts say that Sarah (Abe's stepmother) couldn't even get out of bed to bring somebody water because she was so sick. They were desperately ill," says Sue Massie, with Massie Massie and Associates, a Springfield landscape planning and landscape architecture firm that is the project's prime consultant.
To make matters worse, that winter was the worst in ages. It became known as the "Winter of the Deep Snow." Old settlers considered it a point of pride to have immigrated before then and survived it.
"The Lincolns were extremely miserable (that winter)," says Bauer. "They basically ran out of foodstuffs. They hadn't been able to save enough of the corn and meal to sustain themselves…. They were frozen in and livestock and game were decimated." Abraham rode to nearby homes seeking food for his family.
The next March, barely a year after their arrival, they'd had enough. Thomas and Sarah Lincoln moved to south of Effingham and Abraham went his own way, taking a job as a flatboatman and ending up in New Salem.
After Abe's assassination 34 years later, "a lot of things associated with him almost became enshrined and this cabin became one of those," says Floyd Mansberger, director of Fever River Research in Springfield, which is conducting an archaeological and archival assessment of the cabin site.
While Mansberger says "there's a lot of folklore associated with the cabin and it's hard to tell what's true and what isn't," he's pieced together some facts. Shortly after Lincoln's burial, one or both of the Hanks brothers carefully deconstructed the cabin, rebuilt it and exhibited it at the Illinois Sanitary Fair in Chicago. "From there it went to Boston and sat on the Boston Common for several months," Mansberger says. "From Boston it went to P.T. Barnum's Museum in New York City, and then it disappeared." There's evidence John Hanks planned to exhibit the cabin in Europe, but the paper trail ends there.
Mansberger and his team didn't find any evidence of the cabin when they surveyed the park site, but that's not surprising, he says. "You have to keep in mind this kind of short-term cabin is a very ephemeral kind
of thing to find archaeologically. They didn't leave a lot of evidence on the landscape."
There are illustrations and primitive photos of the cabin, but their
authenticity is suspect. Based on research, Mansberger believes "it was a fairly primitive cabin, typical of the period of early settlers. It had
one room. Its dimensions are hard to say, 18 by 20-foot square, something like
that. It had one story, maybe with a small loft…, and a 'stick in the mud' chimney-fireplace complex off one end. It's a very typical, first generation, quickly built structure that was needed for
immediate occupation."
Although original renovation plans for the site included building a replica cabin, Bauer said that was scratched due to funding and security concerns. Instead, Massie says current plans include recreating a deteriorating 1940s or '50s monument at the site and doing "a nice job of interpreting what's at the site now," through informative signs and possibly handouts.
She hopes the interpretive information will be available at the site this summer.


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Children under 2
If your child has not turned two and does not occupy a seat, he/she pays 10% of the fare. If your child does occupy a seat he/she will be treated as a child aged 2 to 11.
If your child occupies a seat on the aircraft, please bring with you an authorised car seat to place the child in, considering safety regulations.
Please bear in mind that if the child will turn two before the trip ends, your ticket should be purchased at the 'Child' fare for the whole of the flight.
*On flights IB7XXX operated by Lan Airlines, infants who travel in Business must pay the same fare as adults and will travel in an individual seat, with the safety regulations mentioned above applying in these cases.
When you travel with an infant and bring your own stroller, you have the option of keeping the stroller with you through to when you board the aircraft or checking it in along with the rest of your baggage. If you take it to the aircraft door, you will have to carry it in the cabin, space onboard allowing. If there is not enough space, the flight crew will remove the stroller, place it in the hold and return it to you at the aircraft door upon arrival.
If you check it into the hold, you will have to collect it along with the rest of your baggage on the corresponding belts in the arrivals lounge.
Babies less than 8 months old
There are a certain number of cots for infants who weigh up to 11 kg on each Iberia aircraft on inter-continental flights.
These cots, like the seats for the adults who accompany the infant, do not have to be booked online.
Please book a cot through an Iberia Office in your country, where you can also get information about booking a seat for yourself in the designated cot area in advance. Depending on the cabin class, booking a seat will incur an additional cost.


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"Complementary," Not "Alternative"One potential source of confusion about the role of behavioral medicine, which can lead to unnecessary bias against it, is the use of the term "alternative." Particularly in the case of CFIDS, it should not be construed as an "alternative treatment" because it does not treat disease. Rather, it is complementary or adjunctive to appropriate medical treatment. Its goal is to support and enhance the person's host resistance and help reduce the severity of symptoms.
MethodsThe repertoire of behavioral medicine includes behavioral or psychological strategies which directly influence physiological states. The methods are applied in structured group programs, in individual therapy, and in daily practice at home.
The most fundamental and empirically supported of these strategies is induction of "the relaxation response."' This is a physiological state with beneficial effects for a wide array of symptoms including pain (arthralgias and myalgias), insomnia, gastrointestinal disturbances, anxiety and depression.1Other common techniques include the use of mental imagery, hypnosis, biofeedback, and various breath therapy methods.
Relevant Research FindingsFollowing is a sample of demonstrated effects which appear to have important implications for the symptoms and disease process of CFIDS.
A controlled study measured the effects of a behavioral medicine program on symptoms of AIDS. The treatment group received training in biofeedback, guided imagery, and hypnosis. Results included significant decreases in fever, fatigue, pain, headache, nausea, and insomnia; and increased vigor and hardiness.2
A study of 48 patients with HIV who took a group behavioral medicine program found significantly reduced tension, anxiety, fatigue, depression, and total mood disturbance.3
A controlled study of immunological and psychological outcomes of a group program was conducted with malignant melanoma patients. Results included significant increases in large granular lymphocytes (defined as CD57 withLeu-7) and NK cells (defined as CD16 with Leu-II and CD56 with NKHI), along with indications of increased NK cytotoxic activity. There were also significantly lower levels of psychological distress, and higher levels of positive coping methods in comparison to patients who did not have the group.4
In another controlled study, subjects who were trained to induce the relaxation response showed a significant improvement in NK cell activity, as well as lower antibody titers to a herpes simplex type I antigen. In addition, there were significant decreases in symptoms of emotional distress.5
For another study, researchers examined the impact of regular induction of the relaxation response in ameliorating the effects of stress in healthy subjects. The frequency of practice of the technique was significantly and positively associated with the percentage of T-helper cells circulating in the blood.6


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Andres McConnon
Photo: © Helen Tansey
About the Author
Andres McConnon is a researcher, journalist, and award-winning author who has written for Sports Illustrated, the Huffington Post, and the National Post. He has appeared on NPR and other radio stations across the United States and on television and radio stations around the world. He graduated magna cum laude from Princeton University.


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Educating Girls: A Handbook (2003)
A basic reference guide for CIDA staff in Canada and in the field
Author/Publisher: CIDA
Language: English
Download: PDF
The handbook is meant to provide support for field staff, project officers, project team leaders, and project directors in implementing CIDAs Action Plan on Basic Education.
Educating Girls: A Handbook is aimed at assisting CIDA staff in understanding and addressing critical issues related to girls education. It emphasizes CIDAs strong agenda on girls education as part of its Education for All (EFA) commitment to eliminating gender disparities in education by 2005, and ensuring access to free and compulsory primary education for all by 2015.


text: "Pump up the party and download all-new moves from ""My Main Girl"" by MainStreet on Just Dance® 2014! Written by Willem Laseroms, Maarten Ten Hove and Joachim Vermeulen Windsant. Published by Universal Music Publishing Group a division of Universal Music Canada Inc. Courtesy of Universal Music B.V., The Netherlands under license from Universal Music Enterprises. Music Downloads Not Rated by the ESRB


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In response to how the Star Wars trilogy not being released on DVD, GL is doing that just to make more and more money.
I've seen the Original Trilogy out there as a bootleg DVD set for some time. This weekend, I was definitely tempted to buy theatrical versions of the OT as a set for $50. So, here are the questions: -Are you for or against bootlegging in general?-Do you have the Original Trilogy as bootleg DVD's?-If you did, what did you pay?-Did you get the Special Edition, or the Theatrical Releases?And lastly, how long do you think it will be until the original trilogy comes out on DVD?
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Michael is CEO of Dell Technologies and shares insights about the power and promise of technology.
Chad Sakac, President of EMC's Converged Platforms and Solutions Division, offers an insider perspective and technical tips and tricks in the era of the VMware Revolution.
Join Sam Marraccini for an insiders perspective on Dell EMC The Source Podcast
Dell EMC Fellow and VP of Corporate Strategy & Innovation, Steve Todd shares insights from his third decade of storage software.
Bill is the author of "Big Data: Understanding How Data Powers Big Business" published by Wiley.


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Ranchers will have an opportunity to ask two of New Mexico's top veterinarians their questions about herd health during a Ranchers' Roundtable on Wednesday, March 19, at New Mexico State University's Southwest Center for Rangeland Sustainability in Corona, N.M.
Panel members will be John Wenzel, NMSU Extension veterinarian, Tim Hanosh, director of New Mexico Department of Agriculture's state diagnostic lab, and John Pollreis, Zoetis pharmaceutical's technical service veterinarian.
"This will be a great opportunity for New Mexicans to get answers to questions about all things animal health, from current disease monitoring and occurrence, vaccination protocols and which vaccine is important, to what to be on the lookout for that may influence livestock movements across the state and to other states," said Shad Cox, superintendent of NMSU's Corona Range and Livestock Research Center. "Also, a veterinarian from Zoetis will delve into the details of developments in and effectiveness of current vaccines."
The program will be from 10 a.m. to 2 p.m. Lunch will be served. For directions to the center, visit the Corona Range and Livestock Research Center's website at www.coronasc.nmsu.edu.
Source: NMSU Extension
'Internet of Things' Coming Soon to a Field Near You
Closing Market Commentary -- March 7, 2014


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Pharmaxis Launches ARIDOL® (Mannitol Inhalation Powder) Bronchial Challenge Test Kit for the Assessment of Bronchial Hyperresponsiveness
First Product Launch for Pharmaxis, Inc. in the U.S.
Feb 23, 2011, 04:20 ET
EXTON, Pa., Feb. 23, 2011 /PRNewswire/ -- Pharmaxis, a global specialty pharmaceutical company focused on therapeutic products for chronic respiratory and immune disorders, announced today the commercial launch of ARIDOL® (mannitol inhalation powder) Bronchial Challenge Test Kit, the first new bronchial challenge test in more than two decades and the company's first product launch in the U.S. ARIDOL is used to assess bronchial hyperresponsiveness in patients six years of age and older who do not have clinically apparent asthma. ARIDOL should not be used as a stand alone test to assess asthma or as a screening test for asthma, but as part of a physician's overall assessment of asthma. ARIDOL can be ordered directly from Pharmaxis and is available to pulmonary function labs and physicians' offices by calling Pharmaxis Customer Service at 1-888-416-1828.
"ARIDOL is an important advancement in bronchial challenge testing – the first in 20 years – and a significant addition to the tools available to help in an overall assessment of asthma," said Stephen Beckman, President, Pharmaxis, Inc. "We are excited to provide patients and the medical community with an effective, accurate and reproducible test that can be conducted in the convenience of a pulmonary function lab or physician's office."
ARIDOL is a single-use, indirect test that is easy-to-administer, requires minimal preparation time and a 15% reduction in lung function from baseline for a positive test. ARIDOL was approved by the U.S. Food and Drug Administration (FDA) on October 5, 2010, and demonstrated safety and efficacy in two Phase III clinical trials.
"The ARIDOL Bronchial Challenge Test takes only about 20 minutes to administer for a positive test and requires a 15% reduction in FEV[1]. Previous options may take up to 40 minutes to implement and require a 20% reduction in FEV[1]," said Bradley Chipps, MD, Capital Allergy and Respiratory Disease Center, Sacramento, CA. "The ARIDOL Bronchial Challenge Test offers health care professionals another tool to help with a disease that is often hard to definitively diagnose."
"PHARMAXIS is committed to bringing our therapeutic advances for respiratory and immune diseases to patients throughout the world. The U.S. launch of ARIDOL highlights this commitment and our focus on helping physicians and patients world-wide affected by respiratory illnesses," added Mr. Beckman.
How ARIDOL Works
The ARIDOL test requires patients to inhale increasing doses of dry powder mannitol from a simple, hand-held device, which causes airways to narrow and contract when airway inflammation is present. The doses are contained in capsules that are administered at one-minute intervals until a positive response is achieved or until all the capsules have been inhaled, indicating a negative result. A positive response is indicated when there is a 15% reduction in lung function from baseline compared to a 20% fall required by a methacholine challenge test.(1) The lower the dose required to cause bronchoconstriction, the more severe the bronchial hyperresponsiveness.
Other Bronchial Challenge Tests
Unlike other bronchial challenge tests, ARIDOL is a single-use test that requires less preparation time and eliminates reconstitution, use of a nebulizer to administer, clean-up and sterilization. A positive ARIDOL test is complete in approximately 20 minutes, compared to an average of 45 minutes for a methacholine test.(2) A methacholine test requires additional equipment to administer and a designated testing room with ventilation.(1) Tests that use exercise to assess bronchial hyperreponsiveness require special equipment and conditions, and may not be appropriate for patients with physical limitations.
Safety/Efficacy Profile
The safety and efficacy of ARIDOL as a bronchial challenge test were verified in two global Phase III clinical trials, which assessed the effectiveness of the ARIDOL bronchial challenge test in non-asthmatic patients with symptoms suggestive of asthma and clinically diagnosed asthmatic patients six years of age and older. Approved for use in 19 countries, ARIDOL has been used by more than 44,000 patients, and is marketed in Australia, major European countries and Korea. ARIDOL is included in official international guidelines for the clinical assessment of asthma. Organizations and guidelines endorsing ARIDOL include: the International Olympic Committee Medical Commission's Independent Panel on Asthma, the U.S. Asthma Management Guidelines, the Global Initiative for Asthma (GINA) Report on Global Strategy for Asthma Management and Prevention, the World Anti-Doping Agency and the Australian Asthma Management Handbook. ARIDOL is the only dry powder bronchial challenge test approved for use in the U.S.
Mannitol, the active ingredient in ARIDOL, is a sugar alcohol indicated for the assessment of bronchial hyperresponsiveness in patients 6 years of age or older who do not have clinically apparent asthma.
ARIDOL is not a stand alone test or a screening test for asthma. Bronchial challenge testing with ARIDOL should be used only as part of a physician's overall assessment of asthma.
Important Safety Information
Mannitol, the active ingredient in ARIDOL, acts as a bronchoconstrictor and may cause severe bronchospasm. Bronchial challenge testing with ARIDOL is for diagnostic purposes only. Bronchial challenge testing with ARIDOL should only be conducted by trained professionals under the supervision of a physician familiar with all aspects of the bronchial challenge test and the management of acute bronchospasm. Medications (such as short acting inhaled beta-agonist) and equipment to treat severe bronchospasm must be present in the testing area. If severe bronchospasm occurs it should be treated immediately by administration of a short acting inhaled beta-agonist. Because of the potential for severe bronchoconstriction, bronchial challenge testing with ARIDOL should not be performed in any patient with clinically apparent asthma or very low baseline pulmonary function tests (e.g., FEV[1] <1-1.5 liters or <70% of the predicted values).
ARIDOL is contraindicated in patients with known hypersensitivity to mannitol, the active ingredient in ARIDOL, or to the gelatin used to make the capsules. The product is also contraindicated for patients with medical conditions that may be compromised by induced bronchospasm or repeated spirometry maneuvers.
Bronchial challenge testing with ARIDOL should not be performed in children less than 6 years of age due to their inability to provide reliable spirometric measurements.
Use with caution in patients with conditions that may increase sensitivity to the bronchoconstricting or other potential effects of ARIDOL such as: severe cough, ventilatory impairment, unstable angina, or active upper or lower respiratory tract infection that may worsen with use of a bronchial irritant.
The most common adverse reactions (rate greater than or equal to 1%) were headache, pharyngolaryngeal pain, throat irritation, nausea, cough, rhinorrhea, dyspnea, chest discomfort, wheezing, retching and dizziness. No formal drug-drug interaction studies have been conducted with ARIDOL.
About Pharmaxis
Pharmaxis is a global specialty pharmaceutical company involved in the research, development and commercialization of therapeutic products for chronic respiratory and immune disorders. The company's development pipeline includes Bronchitol™ for cystic fibrosis, bronchiectasis and chronic obstructive pulmonary disease (COPD), PXS25 for the treatment of lung fibrosis and PXS4159 for asthma. Founded in 1998, Pharmaxis is listed on the Australian Securities Exchange (symbol PXS). The company is headquartered in Sydney, Australia with regional offices in the U.S. (Exton, PA), Europe and Asia Pacific. For more information about Pharmaxis, visit www.pharmaxis.com.
(1) Provocholine® (methacholine chloride powder for inhalation) [prescribing information]. Methapharm Inc. January 2008.
(2) Anderson SD, Charlton B, Weiler JM, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10:4.
Please call Daina Cardillo at 203-762-8833 for full prescribing information.
SOURCE Pharmaxis, Inc.


text:
A final column from Boston Globe columnist Brian McGrory
So, a couple of expressions of thanks in this, my last column, at least for now.
First and foremost, thank you, Globe readers, for what you've done yet again on behalf of that extraordinary organization called Christmas in the City. I mentioned last Wednesday that old friend Jake Kennedy was once again short of gifts, thousands of gifts, for his annual party for homeless children and his Christmas drive to help the poor. Readers responded in droves.
You flooded the organization's website. You jammed the phones at Kennedy's physical therapy clinic in Downtown Crossing. Hundreds of you gave $5 and $10, as much as you could afford, and it was extraordinary. One gentleman walked up to Jake as he was working over a patient, handed him an envelope, and walked away.
"Wait for a receipt," Jake called after him.
"Don't need it," the guy said.
When Kennedy thumbed through the envelope, he counted $1,000 in cash.
A Chestnut Hill real estate agent e-mailed to say she was in a Newton toy store, The Learning Express, Wednesday morning, and ran into Steve Grossman, the state treasurer, with toys piled up at the counter for Christmas in the City. Another customer asked if he would deliver some for her, then another, and finally the store owner filled two huge bags and asked Grossman to drop them off.
A couple of downtown financiers put the touch on their friends and came up with $6,500 in cash. Out in the suburbs, George Grey parked a big pickup truck outside his business, Lexington Toyota, to collect toys. Come Wednesday, he had to put a second one out, then a third, and a fourth. "It's like someone turned a spigot on," Grey said. It went on all week, all weekend, up to the Sunday afternoon event and beyond.
In total, you showered Jake with nearly $100,000 in cash and thousands of gifts, making the event a raging success, 4,000 homeless kids made to feel like the holidays have magic, that life offers joy. "We are so blessed to be a part of this, to see this as Christmas," Jake Kennedy said this week. "It brings out the best in everyone."
All of which explains, at least in part, the bittersweet sentiments I feel in leaving this space today. A metro column is, bar none, the best journalism job in Boston, one of the best in America, regular space and freedom of voice in a paper with a readership as sophisticated, dedicated, and passionate as the Globe's.
I've treasured the tips that arrive from all quarters: police officers, social workers, nurses, business leaders. I've treasured the people who have invited me into their homes and their lives. I've treasured the opportunity to point out the ridiculousness of exorbitant corporate salaries and uptight suburbs. I've treasured most of all giving voice to those who might not otherwise have it: the dying gas station attendant in Cambridge beloved by his customers who paid to fly his body home; the Mattapan mother who faced foreclosure years after her son was shot and paralyzed. Readers stopped that from happening.
And now Globe publisher Chris Mayer has offered me the editorship of this paper, an unorthodox selection for him, an unusual path for me. I refrained from telling him he's nuts. He politely refrained from saying the same thing to me.
I'm jumping at this for a variety of reasons. I love the Globe. I love my native Boston. I know well that my talented colleagues do vital work, holding powerful people accountable, telling fascinating tales, offering arresting photographs, creating powerful graphics, producing extraordinary videos, in print and on screens.
It's a tough time in newspapers, but the journalism at the Globe is thriving in the face of steep odds, because of great people, the staff and the people who read us.
This column has been the richest privilege of my professional life, and for that, I want to thank you. This next job will be the greatest responsibility. What they have most in common is a bedrock commitment to the well-being of this community, and that will never change.
Brian McGrory can be reached at firstname.lastname@example.com.


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Staff writer
Soybean harvest is moving at different paces around the county. Not only are some farmers waiting for their fields to ripen, but also rain has set harvest back in some areas.
Hillsboro Cooperative Grain and Supply said they have not gotten much rain.
"Other areas around the county have gotten some rain, but it's been by passing us," grain coordinator Dick Tippin said Monday. "Last Friday when a big storm rolled through we were lucky and it missed us. Today it looks like it will be wet."
Cooperative locations in Hillsboro, Marion, and Canton have taken in more than half a million bushels of soybeans, Tippin said.
"We haven't calculated yields, but I've heard of some getting 40 to 60 bushels per acre," he said.
Tippin said average for this area is around 30 bushels per acre.
He projects soybean harvest to be over by Nov. 1.
"We have some fields that aren't ready yet because they were double cropped on wheat fields," he said. "Those mature slower, but should be ready in the next few weeks."
Mike Thomas, Marion Cooperative Grain and Supply manager, said he expects yields averaging 35 to 40 bushels in the Marion area.
"Everything looks pretty decent," he said, "but this is just the beginning. We've still got a long ways to go before all the grain is in."
Harvest could last until November, Thomas said.
"We've got people still bringing in corn," he said. "We're about 85 to 90 percent complete with that and then people can start cutting beans quicker, but in a few weeks milo will be ready too, so it will be an ongoing harvest."
Stan Utting, general manager of Agri Producers in Tampa, said yields also look good in the northern part of the county. According to Utting, most farmers in that area are averaging yields in the 30s and 40s or slightly above average.
"Harvest here has been going on for a couple of weeks, and will continue to go on for a couple more," he said. "Rain today, Monday, will slow things down a bit."
Phil Timken, location manager for Peabody Mid-Kansas Cooperative said they are also seeing average yields.
"I would say its roughly a little over half done," he said. "We're seeing pretty average yields in 30 to 40 ranges. Some better, some not quite so good. Think double-cropped beans are going to be around 20 bushels per acre. That's about average for double crop."
Timken said he is thankful for the rain, and that it helped produce exponentially better yields than last year.
"The rain we had at the beginning of August definitely saved the beans around here," he said.


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Goldman Sachs Reportedly Accepting ?Subprime? Apple Card Applications
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Goldman Sachs Reportedly Accepting ?Subprime? Apple Card Applications
With the Apple Card roll out in full swing this week, a lot of people have been applying to get Apple's new credit card.
With the Apple Card roll out in full swing this week, a lot of people have been applying to get Apple?s new credit card. Though some are being denied, many more are being approved, reads a new report from CNBC.
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Per the report, Apple wants to make the Apple Card as accessible as the iPhone, so it nudged Goldman Sachs, the lender of the card, to approve a large majority of applications so as to be inclusive and provide a good user experience.
?The bank, which is in charge of deciding who gets the Apple Card, is accepting some applications from users with less-than-stellar credit scores, according to people with knowledge of the matter,? reads the report. ?Goldman began to make the card available to some Apple customers this week ahead of a broader rollout later this month.? While there is technically not a definition for a subprime borrower, it?s generally accepted that a FICO score under 660 falls under the title. The original report shares the story of one Apple Card applicant, Ed Oswald, who has a credit score around 620:
?I was absolutely shocked I got it,? Oswald said. ?I have a lot of collections from two or three years ago when I was in a really rough spot. When I heard it was with Goldman Sachs, I figured they were going for the high-income set.?
See the full story in the original source
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text:
The dsconf command requires some options that you can preset by using environment variables. If you do not specify an option when using the command, or do not set the environment variable, the default setting is used. You can configure environment variables for the following options:
User bind DN. Environment variable: LDAP_ADMIN_USER. Default: cn=Directory Manager.
Password file for the user bind DN. Environment variable: LDAP_ADMIN_PWF. Default: Prompt for password.
Host name. Environment variable: DIRSERV_HOST. Default: local host.
LDAP port number. Environment variable: DIRSERV_PORT. Default: 389.
Specifies that dsconf should open a clear connection by default. Environment variable: DIRSERV_UNSECURED. If this variable is not set, dsconf opens a secure connection by default.
For more details, see the dsconf(1M) man page.


text:
Matthew Langdon was the LCHS September Student of the Month
Send a link to a friend
07, 2014]
In partnership with Lincoln
Community High School, Town and Country Bank, at 303 Pulaski St. in
Lincoln, announced Matthew Langdon as the LCHS September Student of
the Month.
His school activities include band, speech and Thespians, in
addition to numerous school plays, group interpretation and National
Honor Society. He is extremely active in the community, volunteering
for the Lincoln Area Music Society, Lincoln College Jazz Band and
the Lincoln/Logan Food Pantry, as well as with the First United
Methodist Church Youth Mission Team.
Town and Country Bank sponsors the Lincoln Community High School
Senior of the Month and Senior of the Year award and scholarship
program. Each month's honoree receives a $50 MasterCard gift card
and is then eligible for a $1,500 scholarship, all awarded by the
bank. The scholarship is used at the college of the student's
[to top of second column]
For more information about the program, contact Town and Country
Bank's Lincoln office, 217-732-3151.
[Text from file received from
Town and Country Bank]
Town and Country Financial Corp. is the
parent holding company for Town and Country Bank and Town & Country
Banc Mortgage Services Inc. The company provides comprehensive lines
of retail, commercial, agricultural and mortgage banking as well as
trust and investment services to families, businesses and
organizations. For more information about the bank, visit
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Today we're coming to the crux of the whole matter. We're getting to the point where we can finally figure out what your ONE thing in life aught to be, and how you […]
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text:
At 15, Tim Eaves has already shown an industrious side.
Before he left for summer camp, he bought new school shoes with money he made from buying a surfboard at a garage sale and reselling it on eBay.
He kept the white athletic shoes at home in Mission Viejo so they wouldn't get dirty when he left for camp with the YMCA of Orange County.
The eBay transaction is something he learned from his dad, an electrician, who was out of work because of the recession. Tim, 15, enjoys going with his dad as he hunts for bargains to sell online.
"He's like the best kid ever," said Tim's mom, Debbie Eaves. "He doesn't want stuff. He appreciates what he gets."
Tim, who lives with his parents and two brothers, appreciated the chance to attend summer camp for the second time because of a scholarship from the Register Campership Fund. He served as a counselor in training, working with younger children.
Tim said camp is a fun opportunity to spend time with friends without worrying about getting bored or finding transportation to go places.
"It occupies your time," Tim said. "You have stuff to do. You really get to bond with your friends. It lets kids get freedom. You get out and just have a good time with your friends."
Debbie Eaves said her son is an experienced camper from family trips so she didn't have to remind him to wear sunscreen or bug repellant. She was happy to see him develop more leadership skills. He likes playing sports and is also active at Saddleback Church.
"There's a lot of love at these camps," Debbie Eaves said. "When Tim comes, there's a lot of hugs. He comes back happy, like he really enjoyed himself and is grateful that he got to go."
When Tim came home after seven days away he said hi to his neighborhood friends and then took a late afternoon nap.
"They set it the perfect amount of days because you want to stay but you're also excited to see your family," Tim said of his week at camp.
As summer draws to a close, Tim said he hopes more Orange County kids will get to go to camp next year through the Campership fund.
"For me, it's worth it," he said.
Click here to learn more about Campership or to donate.
Contact the writer: firstname.lastname@example.com 714-796-3686


text:
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