text:
Watch "In-Fisherman" TV on Sportsman Channel.
Doug Stange joins Capt. Aron Kastern on Lake Superior near Ashland, Wisconsin where they go after whitefish on ice.
The In-Fisherman staff focuses on high-profile fishing situations as they fish the night shift for moonrise walleyes.
Doug Stange uses brown-down jig patterns for big bluegills.
In-Fisherman-Yeti Hopper
Join Doug Stange and Australian pro angler Kim Bain as they venture off the coast of Orange Beach, Alabama to catch hard-pulling head-throbbing redfish.
Doug Stange joins Jim Martin on a trip to catch giant jumping sturgeon!
Ted Takasaki of Lindy Legendary Fishing Tackles shows off their new XChange Jig System that allows you to instantly change the size and color of your jighead without having to retie.
The new and impressive Rapala Clackin' Rap features a steel ball encased inside an exposed sound chamber that ultimately produces an unmatched strident clacking sound.
Jim Coble of Pure Fishing shows off a new line of feature-packed Fenwick Walleye Rods, including an impressive new trolling rod series with a linecounter built into the rod.
Guide Jason Schultz and Doug Stange rig for king salmon.
The In-Fisherman staff visits world-class waters and uses time-tested techniques to jig up Florida Keys Tarpon.
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Welcome to the NCGenWeb Project. The NCGenWeb Project is part of the national USGenWeb Project and is the home of a network of volunteers working to provide you with genealogical & historical content for each of North Carolina's 100 counties. The state is bordered by Virginia, Tennessee, Georgia & South Carolina.
Here at the NCGenWeb Project you will find many resources, including:
- sites for every county in the state
- learning you can contribute and volunteer to help
- a directory of NC genealogy social media accounts
- special projects & resources like our African-American Special Project and our NC Yearbook Index
State Coordinator: Deloris Williams
Assistant State Coordinator #2 & Webmaster: Taneya Koonce
Coastal Counties Regional Coordinator: Susan C. Griffin
Eastern Piedmont Counties Regional Coordinator: Natasha Miles
Western Piedmont Counties Regional Coordinator: Sylvia Hill
Mountain Counties Regional Coordinator: LaRae Halsey-Brooks
Board Advisor: Derick S. Hartshorn
Honorary Board Member: Katherine Benbow

subset: commoncrawl


text:
Obituary index
Warren Delano Rogers
Send a link to a friend
[June 22, 2014]
- Warren Delano Rogers, 75, of Elkhart, passed away on Friday, June
20, 2014, at Vonderlieth Living Center in Mount Pulaski.
4 to 7 p.m. Tuesday at Fricke-Calvert-Schrader
Funeral Home in Lincoln and one hour prior to the
service Wednesday at the church.
11:00 a.m. on Wednesday at the Elkhart Christian
Funeral home:
Fricke-Calvert-Schrader, Lincoln
Warren Delano Rogers, 75, of Elkhart, passed away on
Friday, June 20, 2014, at Vonderlieth Living Center
in Mount Pulaski.
Warren was born on April 20, 1939, in West
Frankfort, son of Harry Delano and Geneva Pearl
Bowman Rogers. He was united in marriage to Suzann
Tesmer on December 19, 1970 in Lincoln. She survives
him in Elkhart. He is also survived by his
daughters: Susan J. (Reggie) Lyons of Odin;
Christina "Tina" Smith of Lincoln; Carrie L. (Matt)
Fights of Elkhart; grandchildren: Benjamin,
Christopher, and Katie Lyons of Odin; Faith J. and
Jaxson W. Smith of Lincoln; great grandchild Braedon
Lyons; "adopted" daughter, Marilyn Renner of Chicago
and "adopted" grandson, Cole Eimer of Springfield.
He was preceded in death by his parents, sister, and
granddaughter, Hope Fights.
Warren retired from the Illinois State Police, and
he owned/operated a construction company since 1986.
Warren was an active member of the Elkhart Christian
Church. He attended Lincoln Christian University, he
received a President Life Saving Award in 1975
through the American Red Cross, and he was a Courier
Citizen of the Month in 1982. Warren also served as
an Elkhart Fire Chief for 11 years and as a Logan
County Deputy Coroner.
Cremation rites will be performed. A memorial
service will be held in his honor at 11:00 a.m. on
Wednesday, June 25, 2014, at the Elkhart Christian
Church. A visitation will be held from 4-7:00 p.m.
on Tuesday, June 24, at Fricke-Calvert-Schrader
Funeral Home in Lincoln and an hour prior to the
service on Wednesday at Elkhart Christian Church.
Memorials may be made to the Elkhart Christian
Church Building Fund, or to Lincoln Christian
Click here to send a note of condolence to the Rogers family.
Did you know.....
...You can send a
condolence note to families via email?
Fricke-Calvert-Schrader, Peasley,
Quiram-Peasley and
Holland Barry & Bennett funeral homes have this option
Click on the name of the appropriate
funeral home (in the line above) and insert the family name to
send a note.
< Obituary index
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text:
Welcome to BugWise Backchat
Welcome to Bugwise Backchat where you can be part of the science that happens at the Australian Museum. Help us be Bugwise by telling us what you've found, asking us questions about the world of invertebrates and sharing your stories from investigations using Bugwise tools.
We are developing Bugwise for Schools to allow school communities to engage in science using simple, rigorous tools for investigating invertebrates in the natural world. In 2009 we developed the Web2Spider toolkit for schools and introduced it to over 4000 students and teachers in NSW. Maybe you are using Web2Spider in your classroom or School Environmental Management Plan (SEMP)? Let us know what you thought and how you have adapted the tool-kit for use in your school or community by completing this brief survey.
2010 is the International Year of Biodiversity and Bugwise is a great way to engage with invertebrate biodiversity as a standalone activity or as part of a comprehensive unit of work across different parts of the curriculum. How many new species can we add to the Biodiversity Counter?
This month we are working on another Bugwise for Schools module – Plant2Polinator which will be launched at the Australian Museum on 22 April. We will be trialling this new toolkit in the first half of the year with workshops for students at teachers at Science in the Suburbs and Science in the Bush and via-video conference. Please join us!
Can't make a workshop? Then start using the Bugwise for Schools toolkits in your classroom with the help of our "video how tos" from April 2010, curriculum links and other support materials that we are developing for this site. Upload and share your photos on our flickr site (from April 2010) but most importantly share your work with the Bugwise community of teachers, students, researchers and community groups
We have lots of plans for the Bugwise project over 2010 and beyond which we will share with you on BugWise Backchat, we look forward to hearing your insect ideas, thoughts and project findings too!


text:
Designer: Sarah Jane of Sarah Jane Studios
10" square solid white (pillow center)
9x21" pieces (fat eighths) pink-and-white stripe, blue-and-white chevron, and blue whale print (borders)
3⁄4 yard backing fabric
22" square batting
20" square pillow form
Water-soluble marking pen
Embroidery floss: gray, yellow, red, pink, magenta, light blue, blue, light gray, and tan
Finished pillow: 20" square
Yardages and cutting instructions are based on 42" of usable fabric width.
Measurements include 1⁄4" seam allowances. Sew with right sides together unless otherwise stated.


text:
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Halloween Fanatic: Published Artist, Collector, Blogging Enthusiast
Halloween Fanatic Originals art, and images there of are property of Robert Brawley-H.F.O.
Find my art locally at GG's in Historic Downtown Statesville
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Check out my friend Darryl Moland's blog The Decorated Tree here
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Feel free to grab a button and link back to my page!
Love my Twinkles...
Visit Johanna's web page here!
Check out my friend Flora's work at Bone Head Studios
Click on picture above.
Check out my friends Paul and Lianne's page by clicking on the image below.
TWINKLE by Christopher Klingler check out his work by clicking on Twinkle's image
By Christopher Klingler
The Martha Stewart Blog
Designs By CK
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Young House Love
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Danita Art
EHAG Emporium
Celebrate365 ... a journal for the ornament enthusiast
From the Studio of Pat Benedict
Blog — Greg Guedel
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Woodstown Whimsies
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Beckett Pottery
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noodle and lou studio
and other silly things
Johanna Parker Design
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A Pinch of Prim
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Murphy Bears
sUrpRiSe deLiGht jOy
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Miss Mindy
amber leilani middleton
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Rabbit Hollow Prims
Spooky Spells
Postcards from FunTown
Dennis Haynes Designs
LuLu Kellogg
Holiday...with Matthew Mead
Retro Rudolph's Retrospective
A Nostalgic Halloween
What's new At Frame By Frame
R. C. Eberz Artist and Illustrator
All Hallows' Evening
Dolls by Allen W. Cunningham
Greg Guedel
Holiday Folk Art By: Debbie Hawkins
Rucus Studio
Wicked Wool Gathering
Chicken Lips
Lisa Snellings
Sweet B Folk Art
Bottle Whimsies
SpOoKyTiMe JiNgLeS
tadpoles and teacups
The Polka Dot Pixie
Vintage Palette Art
Myko Bocek Studios
Society of Eclectic Halloween Artists
Creep Softly Studios
Honey Girl Studio
Felt Musings from Sycamore Moon Studios
My Little World
Tumbleweed Trails
Just Clayin' Around
mealy monster land
Crescent Hill Designs
Paul Scott Designs
Olde Cape Primitives
Hal⋅low⋅e'en Jet-set(ters)
pelpa, etc.
Alphabet Studio
Halloween Etsy Artist Team
Meet the Artists of EHAG
jessica jane: military wife & artist.
FOLK lifestyle
Magical Holiday Artists on Etsy
Kooky and Spooky
The Child's Paper
Because We Believe-Art
The Carver
Garb-oodles Soup
My Brainchild
About Me
Halloween Fanatic
View my complete profile
PROUD ARTIST MEMBER OF BWBA: Beacuse We Believe In Art
Please visit our blog, and look for us on EBAY!
Proud Collector Member of EHAG
Proud Artist Member of The Halloween Art Guild
The Halloween Art Guild
Proud Artist Member of HA31
HA-31 A Gathering of Halloween Artists
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Spooky Time Jingle Guest Artist
December 2011
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Thursday, September 8, 2016
Come by Ya'll next Friday to the Fall Statesville Art Crawl...
Next Friday, September 16, 2016 is the
Fall Statesville Art Crawl
I will again be located at GG'S Art, Frames, and Gifts,
stop by and say HI!
(I stopped by today and dropped off my originals)
Robert~Halloween Fanatic Originals
Posted by
Halloween Fanatic
fall art crawl
Halloween Fanatic
haunted house
Robert Brawley
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Find my art locally at Sanctuary of Davidson in Davidson, N.C.
2014 Artist
Spirits in Sanford
2014 Participating artist
Halloween Fanatic and Twinkle
by Aaron Nieradka @ Everyday is a Holday
Halloween Fanatic on Instagram
See my art in the following
Art Doll Quarterly Fall 2014
Pre-order now or available on Newsstands August 1st!
Spirits in Sanford 2013 ADQ Ad
Art Doll Quarterly
Spirits in Sanford Ad
Halloween Fanatic Ad
Winter issue 2012-2013
Ad as seen in Artizen
Halloween with Matthew Mead
Five pages all about Halloween Fanatic Originals
FOLK Fall 2013
Artist Profile
Halloween with Matthew Mead Fall 2012
Newstand cover
DOLLS Magazine
So honored to be included with Scott Smith (Rucus Studio), and Sylvia Smiser
FOLK Winter
FOLK Premiere Issue Fall 2011
Celebrate 365: A Journal for the Ornament Enthusiast Spring 2011
Celebrate 365 Late Fall 2011
Celebrate 365 Winter 2011
Celebrate 365 Winter 2010
Cloth Paper Scissors
Celebrate 365: back cover!!!!
Celebrate 365 Summer 2010
Celebrate 365 Fall 2009
Collector Feature
Matthew Mead and myself
Connie Porcher: Owner/ Creator of Celebrate 365 A Journal for the Ornament Enthusiast and me
Meeting Lucky Stradley at Clay on Fire
Visit at my home with Dani and Brandi
Spooky Time Jingles Artists
Fanatical Trick-or-Treaters!


text:
Eklund wrote:Make a smilie riding a horse, or two guys jousting.
Throndor wrote:A cannibal.
mencot wrote:Very cool smilies Klorox they are all great
Could you make a smiliy that represents the LCC project thats going one here on Classic Castle in the stories section, i dont really know how it would look, maybe you come up with something
theboywarrior wrote:Mesa like! How about a peasant? you know, like with the classic peasant hood.
Eklund wrote:We need the fleshie smilie getting cut in half by a normal yellow smilie.
Users browsing this forum: No registered users and 1 guest


text:
Hip-hop star Nathaniel Dwayne Hale, known by his stage name Nate Dogg, has died aged 41. The cause of his death is unclear but the Californian rapper had been recovering from two strokes he suffered in recent years.
In 1991, he formed a rap trio with Snoop Dogg and Warren G, and first found fame as a guest on Dr Dre's classic album The Chronic. With Warren G, he had a huge hit with Regulate, which reached No 5 in the UK charts in 1994. In total, he featured on four UK hits and also collaborated with Eminem, Ludacris, Tupac Shakur and Mark Ronson.
SEE ALSO: Eminem's 'Letter To Detroit'
"We lost a true legend n hip hop n rnb" Snoop Dogg tweeted. "One of my best friends n a brother to me since 1986 when I was a sophomore at poly high where we met. I love u buddy luv. U will always b wit me 4ever n a day u put the g n g funk u put the 1 n 213 n u put yo stamp on evrybdy u ever didit wit."
"I miss u cuzz I am so sad but so happy I got to grow up wit u and I will c u again n heaven cuz u know d slogan." Snoop continued. "all doggs go to heaven yo homie n baby brotha bigg snoopdogg!!"
Hale was left paralyzed on one side of his body following a massive stroke in December 2007 and was struck by a second stroke in September 2008.


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SYNNEX Corporation's President and Chief Executive Officer Kevin Murai Named One of 2012's Top 100 C
SYNNEX Corporation's President and Chief Executive Officer Kevin Murai Named One of 2012's Top 100 Channel Executives by UBM Channel's CRN
Mr. Murai honored for fourth consecutive year
FREMONT, Calif.--(BUSINESS WIRE)-- SYNNEX Corporation (NYS: SNX) , a leading distributor of IT and CE products and services, announced today that Kevin Murai, President and Chief Executive Officer, was named one of the Top 100 Channel Service Leaders in the Channel by CRN. This annual list salutes individual channel executives for implementing new strategies and programs as a way to increase partner sales while shaping their own organization's future.
Mr. Kevin Murai, President and Chief Executive Officer, SYNNEX Corporation (Photo: Business Wire)
Mr. Murai was also named one of the Top 25 Channel Sales Leaders for 2012. He was selected for both honors due to his continued vision and leadership, which pushed SYNNEX to its 101st consecutive profitable quarter through the Company's evolution to a more services-oriented organization. Doing so has created deeper partnerships and more sustainable revenue streams for both SYNNEX' vendor partners and solution providers. Additionally, Mr. Murai is leading SYNNEX to new avenues in cloud computing with its CLOUDSolv platform and overall cloud strategy.
In the almost five years Mr. Murai has led SYNNEX Corporation, he has orchestrated progressive moves and investments that have propelled the distributor into a more services-oriented business model. Mr. Murai has more than 20 years of distribution channel experience with focused expertise in global management, operations, information technology and customer relationships.
"I am truly honored to be chosen as one of the Top 25 Channel Sales Leaders in the industry," said Kevin Murai, President and Chief Executive Officer. "Being part of this esteemed group further reinforces the value of SYNNEX' continued growth in providing a unique aggregation of services to both our customers and vendor partners."
CRN's 2012 Top 100 Executives list was based on nominations from solution providers who rated channel vendor executives based on influence, effectiveness and viability, as well as business and sales impact. The CRN Editorial team judged nominees based on sales volume, channel investment and advocacy, and their performance in 2012 CRN research projects such as Channel Champs and the Annual Report Card.
"From sales leaders and innovators to mavericks and up-and-comers, it takes different types of executives with different philosophies to drive success in the IT Channel," said Kelley Damore, Vice President and Editorial Director for UBM Channel. "We're recognizing this year's Top 100 Executives for their commitment to the channel, as well as their willingness to adopt new strategies and policies in order to drive greater sales for partners, while positioning their own company for future growth. We salute these leaders for their hard work and devotion to the technology channel."
Expanded coverage of the 2012 Top 100 Executives will be featured in the November issue of CRN Magazine, online at www.crn.com and on the iPad in the CRN Tech News app.
About SYNNEX Corporation
SYNNEX Corporation (NYS: SNX) , a Fortune 500 corporation, is a leading business process services company, servicing resellers, retailers and original equipment manufacturers in multiple regions around the world. The Company provides services in IT distribution, supply chain management, contract assembly and business process outsourcing. Founded in 1980, SYNNEX employs over 10,000 full-time and part-time associates worldwide. Additional information about SYNNEX may be found online at www.synnex.com.
Safe Harbor Statement
Statements in this release that are forward-looking involve known and unknown risks and uncertainties, which may cause the Company's actual results in future periods to be materially different from any future performance that may be suggested in this release. The Company assumes no obligation to update any forward-looking statements contained in this release.
Copyright 2012 SYNNEX Corporation. All rights reserved. SYNNEX, the SYNNEX Logo, CLOUDSOLV and all other SYNNEX company, product and services names and slogans are trademarks or registered trademarks of SYNNEX Corporation. SYNNEX and the SYNNEX Logo Reg. U.S. Pat. & Tm. Off. Other names and marks are the property of their respective owners.
About UBM Channel
UBM Channel is the premier provider of IT channel-focused events, media, research, consulting, and sales and marketing services. With over 30 years of experience and engagement, UBM Channel has the unmatched channel expertise to execute integrated solutions for technology executives managing partner recruitment, enablement and go-to-market strategy in order to accelerate technology sales. UBM Channel is a UBM company. To learn more about UBM Channel, visit us at www.ubmchannel.com.
UBM plc
UBM plc is a leading global business media company. We inform markets and bring the world's buyers and sellers together at events, online, in print and provide them with the information they need to do business successfully. We focus on serving professional commercial communities, from doctors to game developers, from journalists to jewelry traders, from farmers to pharmacists around the world. Our 6,000 staff in more than 30 countries is organized into specialist teams that serve these communities, helping them to do business and their markets to work effectively and efficiently. For more information, go to www.ubm.com
Photos/Multimedia Gallery Available:http://www.businesswire.com/multimedia/home/20121126006064/en/
UBM Channel
Betzi Hanc, 508-416-1182
For SYNNEX Corporation
Amanda Long, 864-271-0718
KEYWORDS: United States North America Canada California
The article SYNNEX Corporation's President and Chief Executive Officer Kevin Murai Named One of 2012's Top 100 Channel Executives by UBM Channel's CRN originally appeared on Fool.com.Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.
Copyright © 1995 - 2012 The Motley Fool, LLC. All rights reserved. The Motley Fool has a disclosure policy.


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Safety of an HIV Vaccine (AVX101) in HIV Uninfected Volunteers in the United States and South Africa
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
|ClinicalTrials.gov Identifier: NCT00063778
Recruitment Status : Completed
First Posted : July 8, 2003
Last Update Posted : July 2, 2012
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
|Condition or disease
|HIV Infections
|Biological: AVX101 Other: placebo
|Phase 1
This study was designed to evaluate the safety and immunogenicity of an alphavirus replicon HIV subtype C gag vaccine. This vaccine utilizes a propagation-defective replicon vector system derived from an attenuated strain of Venezuelan Equine Encephalitis (VEE) virus. The vaccine replicon expresses the gag gene from a South African subtype C isolate of HIV-1.
This study evaluated the AVX101 vaccine in healthy, HIV uninfected volunteers in both the United States and South Africa. Participants will be randomized to receive either vaccine or placebo at study entry and again at Months 1 and 3. The study was originally designed to enroll four groups of participants in both the US and South Africa, with successive groups receiving increasing doses of the vaccine, but was later amended to enroll only two groups. Twelve US participants (US Group 1) were randomized to receive either vaccine or placebo. After a review of initial safety data from this group, 12 South African participants (SA Group 1) were randomized to receive the same vaccine dose as US Group 1 or placebo, while 12 US participants (US Group 2) were randomized to receive the next higher vaccine dose or placebo. Review of safety data from SA Group 1 and US Group 2 was used to inform the decision to begin enrollment into SA Group 2 .
Participants had nine study visits over 12 months. Study visits included clinical evaluation, urine and blood tests, and HIV tests. After each injection, participants were asked to record their temperature and any symptoms each day for 7 days and report them to the clinic staff.
|Study Type :
|Interventional (Clinical Trial)
|Actual Enrollment :
|48 participants
|Intervention Model:
|Parallel Assignment
|Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|Primary Purpose:
|Official Title:
|A Phase I Safety and Immunogenicity Trial of an Alphavirus Replicon HIV Subtype C Gag Vaccine (AVX101, Alphavax, Inc.) in Healthy HIV-1 Uninfected Adult Volunteers
|Study Start Date :
|July 2003
|Actual Primary Completion Date :
|July 2005
|Actual Study Completion Date :
|July 2005
Experimental: 1 x 10^4 IU dose
Vaccine dose of 1 x 10^4 IU per injection
Biological: AVX101
Alphavirus replicon particle vaccine expressing HIV Gag antigen
Experimental: 1 x 10^5 IU dose
Vaccine dose of 1 x 10^5 IU per injection
Biological: AVX101
Alphavirus replicon particle vaccine expressing HIV Gag antigen
|Placebo Comparator: Placebo
Other: placebo
phosphate buffered saline, pH 7.2, HSA, sodium gluconate, and sucrose
- Grade IV adverse events [ Time Frame: 1 year ]The sample size at each vaccine dose level was selected such that the stopping rule for not escalating the dose (2 or more vaccine-related Grade IV adverse experiences) would be met with high probability if the true toxicity rate was above 15-20%, and such that dose escalation would occur with high probability if the true toxicity rate was less than 5%.
- Local and systemic adverse events [ Time Frame: 7 days after each dose ]Reactogenicity assessments were performed for all participants before and after each injection, beginning 25 to 45 minutes post injection and continuing daily for 7 days. Assessments performed included systemic reactogenicity (body temperature, malaise and/or fatigue, myalgia, headache, chills, arthralgia, nausea, vomiting) and local reactogenicity (injection site pain, tenderness, erythema or induration, and axillary lymph node tenderness or enlargement).
- Binding antibodies by ELISA [ Time Frame: 1 year ]Binding antibodies to commercially available Gag protein (P55 Gag; Quality Biologicals) were assessed by ELISA using single serum dilutions (1/50 or 1/100) on samples taken at baseline, two weeks after the second and third vaccinations and at the final visit. Samples that were positive in the initial ELISA were tested by endpoint titration ELISA using six 2- to 7-fold serial dilutions of serum beginning at a 1/50 or 1/100 dilution. Magnitude of responses is reported as the difference in optical density (OD) in antigen-containing and non-antigen containing wells at the 1:50 dilution.
- Chromium release CTL assay [ Time Frame: 3 months ]A standard 51Cr-release CTL assay was performed on fresh peripheral blood mononuclear cells (PBMC) at baseline and 2 weeks after the second and third vaccinations, using a 50:1 effector to target (E:T) ratio.
- IFN-gamma ELISpot assay [ Time Frame: 3 months ]Bulk T cell responses were assessed by IFN-γ ELISpot, using cryopreserved PBMC collected at baseline and 2 weeks after the second and third vaccinations, and stimulated overnight with Gag peptide pools at 200,000 cells per well.
- Antibodies to VEE virus [ Time Frame: 1 year ]Neutralizing antibodies to VEE virus were measured in serum obtained at baseline, 2 weeks after the second and third vaccinations and at the final visit.
- Replication-competent viral vector viremia [ Time Frame: 2 weeks after each vaccine dose ]Any participant who reported a fever greater than 38oC, or other moderate symptoms consistent with a viral illness (e.g. headache or malaise) during the 7 days following vaccination, or neurological symptoms (e.g. nuchal rigidity, ataxia, convulsions, coma, paralysis) within the window of the 2-week post vaccination visit, provided a serum sample to confirm the absence of replication-competent VEE viremia.
- Lymphoproliferation assay [ Time Frame: 1 year ]A lymphocyte proliferation assay in response to purified Gag protein and/or Gag peptides was performed on cryopreserved PBMC collected at baseline, 2 weeks after the second and third vaccinations, and at the final visit.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
|Ages Eligible for Study:
|18 Years to 60 Years (Adult)
|Sexes Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria
- HIV negative
- Willing to receive HIV test results
- Good general health
- Acceptable methods of contraception for females of reproductive potential
- Hepatitis B surface antigen negative
- Anti-hepatitis C virus antibody (anti-HCV) negative or negative HCV PCR if anti-HCV is positive
- Access to participating site and available for follow-up during the 12 month study
Exclusion Criteria
- HIV vaccines or placebos in prior HIV vaccine trial
- Measurable anti-VEE antibody
- High risk for HIV infection according to HVTN Risk Criteria
- Immunosuppressive medications within 168 days prior to first study vaccine administration
- Blood products within 120 days prior to first study vaccine administration
- Immunoglobulin within 60 days prior to first study vaccine administration
- Live attenuated vaccines within 30 days prior to first study vaccine administration
- Investigational research agents within 30 days prior to first study vaccine administration
- Subunit or killed vaccines within 14 days prior to first study vaccine administration
- Current tuberculosis prophylaxis or therapy
- Active syphilis
- Serious adverse reaction to vaccines. A person who had an adverse reaction to pertussis vaccine as a child is not excluded.
- Autoimmune disease or immunodeficiency
- Unstable asthma
- Type 1 or Type 2 Diabetes Mellitus
- Thyroid disease requiring treatment
- Serious angioedema within the past 3 years
- Uncontrolled hypertension
- Bleeding disorder
- Malignancy unless it has been surgically removed and, in the opinion of the investigator, is not likely to recur during the study period
- Seizure disorder requiring medication within the past 3 years
- Asplenia
- Mental illness that would interfere with compliance with the protocol
- Other conditions that, in the judgement of the investigator, would interfere with the study
- Pregnant or breast-feeding
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00063778
|United States, Maryland
|Johns Hopkins University
|Baltimore, Maryland, United States, 21205-1901
|United States, New York
|New York Blood Ctr- Union Square
|Bronx, New York, United States, 10456
|Columbia University
|New York, New York, United States, 10032
|University of Rochester Medical Center
|Rochester, New York, United States, 14642-0002
|United States, Tennessee
|Vanderbilt University
|Nashville, Tennessee, United States, 37232
|South Africa
|SAAVI Vaccine Research Unit
|Durban, South Africa
|Chris Hani Baragwanath Hospital
|Soweto, South Africa
|Study Chair:
|Donald Burke, MD
|Johns Hopkins University
|Study Chair:
|Salim Abdool Karim, MD, PhD
|University of Natal, Durban, South Africa
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|AlphaVax, Inc.
|ClinicalTrials.gov Identifier:
|NCT00063778 History of Changes
|Other Study ID Numbers:
|First Posted:
|July 8, 2003 Key Record Dates
|Last Update Posted:
|July 2, 2012
|Last Verified:
|June 2012
Keywords provided by AlphaVax, Inc.:
HIV Seronegativity
HIV Preventive Vaccine
AIDS Vaccines
Gene Products, gag
Dose-Response Relationship, Immunologic
Injections, Subcutaneous
Additional relevant MeSH terms:
HIV Infections
Lentivirus Infections
Retroviridae Infections
RNA Virus Infections
Virus Diseases
Sexually Transmitted Diseases, Viral
Sexually Transmitted Diseases
Immunologic Deficiency Syndromes
Immune System Diseases
Immunologic Factors
Physiological Effects of Drugs


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Chubby Puppies & Friends are stumbling, fumbling, tumbling cuteness you'll fall for! This adorable Pug loves to play and has tons of fun doing it! Each Chubby Puppy is unique and waddles and hops in an adorable way. Customize their legs for even funnier walks and hops! These fumbling, tumbling puppies and friends love to run after their toys. The Pug comes with a special drumstick chew toy and hat. It's cuteness overload! Collect all of the Chubby Puppies & Friends for a Chubby Puppies waddle party! Bring home the undeniable cuteness of Chubby Puppies & Friends and adopt your Pug today!
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Is it just me, or is anyone else done with summer?
I want PUMPKIN SPICE!
Who's with me on that?
But in all seriousness - for those of you who are regular readers, hopefully you know by now that I'm very picky about my reviews. Making money off of a hobby is great, but that's not why I blog, and I would never personally endorse a company, product, or recipe I didn't truly like.
In all honesty, I was a strictly-white sugar type of gal until a couple years ago when I was diagnosed with a hormone imbalance; it puts me at a higher risk for diabetes if I'm not mindful about my carb intake. So at that point, I started looking into less-refined sugars and sugar alternatives and was pleasantly surprised to find out there are some really great options available.
For one, Stevia is the only low-calorie sweetener that I actually enjoy - I think it tastes the closest to 'regular' sugar, and I love that it's natural, not made from chemicals.
How cute is that?? To view other photos or make your own, just visit hotintherawaction.com (and perhaps warn your significant other first, in case they see the site in your browser history - ha!)
In the meantime... bring on the pumpkin spice!
- 1/3 C. canned pumpkin puree*
- 1/4 C. Sugar In The Raw®
- 1/4 t. ground cinnamon
- 1/8 t. ground allspice
- 1 C. whole milk
- 4 C. vanilla ice cream (slightly softened)
- Grated nutmeg for garnish


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Sunday, November 21, 2010
Happy Feet
All things interesting and funny have deserted my life as I have been just putting the building blocks together for a good 2011.
-Pilates, lots of pilates. With ballet dancers. Holy crap, these guys/gals are STRONG! And talk about flexible. I'm pretty jealous.
-Physio exercises, oh so many exercises, my feet, calves, glutes and pelvic floor are getting one hell of a work out. Thera-bands, spiky balls, cricket balls, toe separators, foam rollers, thoracic extensions, you name it; I've got it. I'm getting needles in the arse, elbows in the arse, yes I am basically paying a lot of $/hr to get a whole bunch of disturbing and quite uncomfortable things done to my arse. What an odd life I lead...
-Gym, I am building up some semblance of hip stability so I can ride ride ride in the future and not have any issues. Squats, dead lifts, step ups, leg press, balancing on the wobble board! You don't need to be very strong to ride a bike, but you do need to be stronger than me, trust me!
So take the above three activities, repeat them many times during a weekly cycle, add in cycling to and from plus some cruisey rides and somehow I am still doing 20 hours + a week but it feels like I am doing nothing. Unless I come off the bike, exhausted and on the verge of muscle break down it just doesn't feel like I am 'training'. But these are the steps I have to take!
Mind you I wouldn't mind going for a decent ride!
So I'll continue the hunt for some funny material but for the time being I'll leave you with a note of a good experience at our last race in Belgium.
The race was a Pro Kermesse in Geraardsbergen that was up a hill, down around the hill and back up. 10 k laps, coupla k of climbing through the town on a nice bumpy cobbled road. It was cool. Real cool. There were loads of fans and top level bike riders there. Mr McEwen was the biggest rider of note.
Given my aforemetioned foot problems I did not last long. So plan B involved sampling the local tart (of the cake variety) and grabbing a coffee. As I was sitting in one of the cafes I noticed Allan Peiper walk in (which made sense given HTC had a few riders in the race). He must be one of the most recognisable people in world cycling.
I was feeling a bit sheepish and he was with a whole bunch of people so I didn't go over and say hello. That night I was discussing it with someone on facebook who was back in aus. Anyhow, this guy shoots and email off to Allan Peiper telling him that some random Melbourne kid saw him in a cafe at the race. Allan shoots back an email to me straight away saying
"Hi Jono,
Should have said hello but nice you respect people's space!
Where are you living? Maybe we can hook up for a ride or coffee next week.
Sent from my HTC"
A pity but I had to fly home so couldn't go for a ride with him. Damn. But that email made my day. Don't you love the internet sometimes!
Time for some glut activation...
5 comments:
Keep at it tight cheeks.ReplyDelete
- AnonymousNovember 21, 2010 at 3:40 PM
Did the kermesse go all the way to the chapel or turn at the bottom of the real climb? I may done an amateur version last year. I say may as all I can remember is blurry eyed pain.
"yes I am basically paying a lot of $/hr to get a whole bunch of disturbing and quite uncomfortable things done to my arse."ReplyDelete
Some people do the same thing and call it a "lifestyle"! LOL
Anon, it went over the bridge up the guts of the town, onto the paver, not too rough, not 'real' cobbles then turned right well before the chapel. there were a couple of nice sweeping turns on the descent.ReplyDelete
At another race we went up past the Chapel but it used a different street to get through the town, a bit to the left of the road we raced in the kermesse
Wow, that's very cool about Allan!ReplyDelete


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Monday, August 25, 2008
Immediate and Long Term Future
Anyway I figured this is as good a time as any to reflect on the monster I have created here and what its future is.
It's been about 4 months since I started this blog. That means it's been around, oh, approximately 3 months and 28 days longer than I was expecting. I have come to love it in a strange way, and this is emphatically not an announcement about ending the blog. I have no plans at all to end it.
However - I am wondering if there are any changes you would like to see. On my end, it's basically been the same deal - each time there's a new xkcd up, I read it, think about why it's bad, tell myself I should give it another chance, check the forums to make sure I'm not missing something important, and then, usually just before the next one goes up, I write the post. Occasionally some other topic comes up and I write about that.
So there are a few ideas I've had and I am curious which ones you guys think you'd like. For example -
---Branch out - talk about other webcomics more (sort of like the PBF post)
---Mock the forum-dwellers with more regularity - perhaps a weekly post making fun of one commenter in particular
---Go back and analyze some of the older comics, both good and bad
--a variant of that: Intersperse my generally negative comments about the newest comics with analysis of good older ones and why I think they work well
---Tone - meaner? Nicer?
--- More posts from other people
Should I write more? Less? Should I skip the occasional comic that doesn't interest me?
Anything sound good? Or do you have your own brilliant idea?
Basically I am looking for any and all feedback. As usual, put it in the comments or e-mail firstname.lastname@example.com .
9 comments:
Use more limericks, haiku, and sonnets. And villanelles.ReplyDelete
- AnonymousAugust 25, 2008 at 10:48 AM
I wouldn't mind seeing your take on the forums. I think the sycophants there are part of what's allowed Randall to get so lazy.ReplyDelete
Please ignore comics that you don't care about. There's nothing more boring than "meh. whatever."ReplyDelete
I don't really like the idea of pointedly making fun of specific people (rather than making fun of the whole forum, or a specific thread or trend), but that's because I'm a softie who doesn't like inter-site flame wars. The denizens of the xkcd forum seem like the type of Goons who'd flame out quite a bit over any slight.
What Sarah said, plus they'd start examining our snarkiness and I'm only comfortable with feeling better than others, not equal to them. However, judging a mass reaction to a comic is always a good time.ReplyDelete
My favorite posts of yours often bring up older xkcd's (especially ones showing how Randall breaks his own rule-punchlines). If you feel truly indifferent about a certain comic, I would advise that you outsource the rant to a willing guest or attach it to a different comic's post with "About Friday's comic: not bad. On with the show!"
Your mean/nice scale has been pretty well-tuned so far. Just be outright in calling the shitty comics shitty and being a kind analyst when you think a comic is onto something.
- AnonymousAugust 25, 2008 at 2:47 PM
I suggest making fun of the forums when there is nothing really interesting to say about a particular comic (or it happens not to suck).ReplyDelete
I actually like all of the ideas presented on the blog and in these comments, except for the ones for restraint.ReplyDelete
This comment has been removed by the author.ReplyDelete
Does anyone else think Randall may be reading this site and has given Carl a breather for now by posting a meme-related chart?ReplyDelete
C'mon Carl, make up your mind before the dick jokes start back up!
Compare new comics to comics that may have the same general punchline, or even old XKCD comics. I don't think it's enough to tell what's bad about a comic, tell what should replace the material.ReplyDelete


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Quick, what's the one thing everyone knows about Grand Theft Auto? Keep hold of the answer - we'll be back for it in a moment.
I was never sure how to order this post, or what exactly to include in it. So it's been festering in Dashboard for weeks now. Partly it was sparked off by reading criticisms of Iron Man, which blurred between entirely valid digs at the film's racism and sexism, and a less definable discomfort with the entire genre it's part of. See WOCPhD's brilliant post, where she seems to have lost sight of the fact that she's reviewing an adaptation of a 1963 pulp comic book.
That's pulp, where what is right and just comes way second to what's considered entertaining. That's 1963, the past, where a lot of our current media franchises come from - whether it's those comic book adaptations, or Narnia, or James Bond. Not that the newer franchises are a lot better, but (as I said when it came up on Punkass) characters like Pepper make way more sense in that context. The whole wonderboy-hero, powerful enough to do everything we wish to do, except for those boring things his ever-capable sidekick(s) do(es), makes more sense in that vein of pulp than in the current one. This hero-character is always at the top of the world. Why do we identify with him, when he's got nothing in common with reality at all?
Because we want to. Because we're wishing for his absolute power, and we are vividly interested in what the consequences that power might bring. We play sandbox games for similar reasons - a wish for the absolute ability to choose - and that raises discomforts of its own.
(It's always 'he'. Unless the red one is writing it, it's always 'he'.)
There is something Aishwarya said in the Iron Man thread at Daisy's place; "I really, really wish I could just watch movies where things blow up (because movies where things blow up are excellent) without being constantly alienated by this sort of thing. :("
That alienation is one of the major sources of the criticism of Iron Man; that when we leave ourselves behind and go to places where we have infinite power, and can blow up whatever we like, we're almost always asked to identify with white, heterosexual upper-class men. We want to be Bruce Wayne or James Bond. We wish for their momentum, possessions, power, and their challenges. Why do they all have to look the same?
An aside; Cleolinda is talking about a whole other sort of wishing, in a post about a book series that's aimed at teenage girls. I liked this:
Wish fulfillment: I really cannot stress how important this element is, because I think it's also the reason that Harry Potter grabbed the cultural imagination. You're not a neglected orphan sleeping in a cupboard! You're a wizard! You're the bestest wizard of all and you're also great at sports and you had rich, wizardly parents who loved you so much they died for you (but you've still got their money) and also, we brought you birthday cake! And then you, through Harry, are plunged into this fantastically detailed wizard world. I mean, shit, I'm sold. And I think most things that really grab people are going to tap that "I want to be that person and live in that world" vein. I want to be Elizabeth Swann, I want to be Lyra Belacqua, I want to be the Pevensie kids.
She's talking about the same instinct that makes us love those boys who can do anything they want...and yet everything she says about this sort of wish fulfilment turns me off. I don't much like any of the books and films she's referring to. Some of these are in a middle ground - but I seem to be banging my head against the fact that the wishes I like are usually aimed at (we might even say assumed at) a male audience, and Cleolinda is talking about teenage girls, and women who remember being a teenage girl.
A while ago, Trinity wrote about our discomfort with power and excess in an unrelated context - kink!:
Think about standard criticisms of the rich and opulent. Whether they're criticisms of the nobility, of the bourgeoisie, or other criticisms of the rich and powerful. The idea that these people are decadent, that they wallow in excess, drown themselves in pleasure.
That kind of excess is actually a big turn on for me. The idea of going further and doing more, overflowing with energy, desire, and intensity. It's something I began to have a very hard time with when I got into feminist circles that were also socialist or influenced by socialism.
Because the central idea of that kind of political movement is that some people have too much and some people don't have enough. If that's the material situation of people in the world, and I seek to be committed to some kind of distributive justice that least makes the first step to equalizing some of that, how can I get into bed and touch myself while imagining, sometimes literally, that I'm lord over other people?
While not primarily sexual, wish fulfilment stories seem to hit a similar wall in the liberal press; you can't be fantasising about that, that's too much, too violent, too greedy, too unfair. So onto Cate's GTA article at Shameless:
But the object of the game is still to shoot people and win gang wars, right? I find it hard to fathom why so many intelligent people insist on defending this game, whose major appeal I once heard summarized as, "you can sleep with a prostitute and then shoot her so you don't have to pay."
Creative, indeed.
What, is Shameless not so shameless after all? :O Certainly Cate is saying that a virtual world's functionality should contain hard-coded moral limits, rather than simple moral consequences. It is not enough that nothing real can be harmed or lost in the space, or that your virtual self suffers virtual consequences for performing proscribed actions; instead she asks that a line be drawn, and certain evils be rendered impossible. (Something like this exists in Sims 2 - you can't kill a baby or a toddler, can only have sex with adults and elders, and character's genital areas are obscured by pixels. These restrictions have been ripped up by a legion of fanmodders, which demonstrates how practical that approach is, though when choosing nominal imaginary limits, practicality is hardly the point. Worth remembering that it was modders who caused GTA3's Hot Coffee debacle. Ultimately neither lawmakers nor creators can censor the use of game software - it's the users who determine how it is played).
Our species of cyborgs has been wrestling with this problem, of defining our virtual limits, since A Rape In Cyberspace or before.
Dibbell's story touched on one point that has been gaining ground recently; should virtual crimes be subject to real-world consequences? The answer he watched arise from LambdaMOO was a no - those who commit virtual crimes should face justice within the intimacy of the wronged community. Then as now, the internet usually gives its wrongdoers a sentence of exile.
Regina Lynn, writing about a more recent virtual rape, also thinks not. Meanwhile, DailyBits has a list of unexpected real-world spillovers from virtual events; MMO addict deaths and in-game funerals, virtual thefts and real arrests, and a story about a Gunbound player from Brazil that I can barely get my head around.
Last week I read a Cif Arts piece in defence of James Bond that talked about how uncomfortably realistic violence is part of the thrill, when it comes to boy-heroes...and added a few words about consumption and luxury:
Thanks to the cartoon violence of the films it's also easy to forget just how effective the sadism in the novels can be. Fleming's books are creepy and chilling and this graphic cruelty, combined with painstakingly accurate descriptions of high-living, fine eating and the pleasures of quality consumer goods must make Bond a direct ancestor to characters like Patrick Bateman and the unnamed protagonist of Fight Club as much as the promiscuous father of so many lesser pulp-thriller spies. It certainly merits him a place in the canon.
So violence is an intrinsic part of this wishing-ground. Graphic violence, ultimate consumption, extreme adventures - and as the article hints, unlimited access to sex. Sometimes the hero is simply a tireless playboy, but many of these stories include legions of imaginary sex workers.
To my shame, it was only a week ago - and thanks to Chris - that I read the mighty OH JOHN RINGO NO review, which charts an odyssey of violent and misogynistic wish fulfilment. From Hradzka's description, every woman in the series is a sex worker, or described as a potential sex worker; within the fantasy space, all women are perceived as being available for sexual purchase.
Hradzka also mentions a whole aspect to this wish fulfilment thing that I'd never much thought of before:
Once you get past GHOST's initial spleen-venting, the PALADIN OF SHADOWS series falls into a much-maligned, much-loved genre which, for lack of a better name, I call "Man Builds Stuff and Gets Lots of Pussy." This is, quite frankly, what got me reading the series: I am not much for stories of a guy just killing terrorists and getting laid a lot; but let him start building a small kingdom while killing terrorists and getting laid a lot, and I am there. I confess that have a soft spot for these kinds of stories. I suspect that *lots* of men do: even if we don't build things ourselves, we like to *read about* guys building things: castles, weapons, companies, societies. It's really very soothing; it combines the pleasures of fiction with a those of a do-it-yourself manual. The same impulses may explain why a lot of male writers aren't content to have their hero just carrying, say, a 1911 as his sidearm; they have to tell you what make, model, whether it's got an internal or external extractor, what aftermarket parts he's tuned it up with, and who he bought them from, until you know all about his Kimber's Ed Brown slide stop and Wolff springs.
(Curiously, the sex-related parts do not require details of every thrust; if the chapter fades to black with the hero hopping into bed with two nubile wenches, honor is satisfied. John Ringo, alas, often carries honor considerably farther.)
I'd never put a name to that before, but building stuff is definitely a genre I like. I enjoyed this aspect of both Iron Man and Batman Begins...not to mention Metal Gear Solid: Portable Ops, a game in which you have to procure yourself an entire army. (I can think of only one Woman Builds Stuff story - A Town Like Alice by Nevil Shute. While I enjoyed the Woman Builds Stuff part of the book, it seemed rushed and unconvincing compared to the rest of it).
On CiF, Charlie Brooker unwraps the problem, and finds a new one wrapped inside:
The one thing everyone knows about Grand Theft Auto is that you can kill prostitutes in it. That's because it's a "sandbox" game in which you can kill anyone you like. Or you can not kill them. Or you can simply drive around slowly, obeying the traffic lights. If you break the law and the in-game police spot you, they'll hunt you down and nab you. Murdering innocent people is neither a) encouraged, b) free of consequence, or c) any more realistic than a Tex Avery cartoon.
...in other words, the problem is not that you can kill prostitutes, but that prostitutes are a singled-out class of people, neatly prepackaged as a unit by our culture in spite of their great diversity of circumstances, and the killing of this class of people IRL is common and so easy to get away with because of this - so when a game also presents sex workers as a class of people, and just happens to let you kill whoever you like, guess who people get most excited about shooting.
I should add; Brooker's point c) is under dispute. The Slate game review...which is entitled 'It's Not Just About Killing Hookers Any More'...says it's simply not true:
There's a difference this time: The violence is no longer cartoonish. Shoot an innocent bystander, and you see his face contort in agony. He'll clutch at the wound and begin to stagger away, desperately seeking safety. After just scratching the surface of the game—I played for part of a day; it could take 60 hours to complete the whole thing—I felt unnerved. What makes Grand Theft Auto IV so compelling is that, unlike so many video games, it made me reflect on all of the disturbing things I had done.
...and David Wong, in Seven Commandments All Videogames Should Obey (a followup to another wonderful article, A Gamer's Manifesto), devotes an entire page to saying it shouldn't be true:
If we shoot a zombie in the arm, we want his arm to blow off. If we shoot him in the knee, we want him to limp. And if we shoot him in the head, we want his head to explode. We want our bullets to create wounds.
Sword-fighting games like Oblivion are worse. You can slash the bad guy in the face with your blade and it does nothing. The enemy looks perfectly normal until he finally falls over dead, as if he had a heart attack from the excitement. Why give us a sword if we can't decapitate people? Don't tell us the system can't handle it, we were blowing off zombie limbs in House of the Dead a decade ago.
It's not about our blood thirst (well, not just about that), it's about making us feel like we're accomplishing something as we work our way through hordes of cookie-cutter bad guys. Oh, hey, you know what else we hate?
Filling the game with hordes of cookie-cutter bad guys.
This is another one of those problems that are exacerbated by new-gen graphics. Now that we can do photo-realistic faces, it's suddenly very weird that we're killing hundreds of identical clones.
How hard would it be to randomize facial features and skin tones? That's what we want, to feel like we're killing hundreds of different people. Not a bunch of clones or twins. We want to know, deep down, that there are hundreds of grieving mothers out there, lamenting the terror of our dreaded blade.
And I agree with him, I agree with Slate - we need the effects of our actions to look realistic, and the media queasies have repeatedly demonstrated the reason for this.
The first time I read an article about violence in videogames was almost ten years ago. It was in a library newspaper - probably the Times - and it mentioned several games, but was illustrated with one of Nomura's promotional images for Final Fantasy VII; a game that uses violence, questions it, and at one point devolves into an argument between Cait and Barrett about whether any of the violent things they've been doing are remotely justified.
That was the moment I first realised that I was never going to read anything of value about videogames in a printed newspaper, ever. Why shut up and go away when you can challenge and explore instead?
This is why my least favourite scene in Iron Man was the one that steamrolled over #6 of David Wong's Ultimate War Sim demand list:
Speaking of innocents, I want a war sim where native townsfolk stand shoulder-to-shoulder on every inch of the map and not a single bomb can be dropped without blowing 200 of them into chunks. Forget about the abandoned building wallpaper in games like the Red Alert series. I want to have to choose between sending marines door-to-door to be killed in the streets or leveling the block from afar, Nuns and all. I want to have to choose between 40 dead troops or 400 dead children, and be damned to hell by chubby pundits from the safety of their studios regardless of which way I go.
See, Wong is a gamer kid with a good grip on reality. There exist other gamer kids who think reality is like Iron Man, where magical white people who waltz into other people's countries have the magical power to distinguish between nice, innocent brown people and evil brown people (there are no other kinds, just innocent or evil), remove the latter with pinpoint precision, and go home after a day well saved. These other gamer kids are called the US government.
It's the people who don't want their imaginary violence to be realistic that I worry about. The people who want the details glossed over, who want to make out that it's not as bad as it really is, who want to conceal the fact that it's the least powerful who always suffer first and most.
One last link: Catherine Bennett on GTA. Oh dear god, you must read this:
With a violent and nasty movie, or corrupting literature, the thing is simple. You merely have to buy a ticket for, say, No Country for Old Men, or There Will be Blood, and watch it, with a keen eye for anything that might be violent or nasty. With books, you simply open, then read a copy of The Catcher in the Rye or, to go back a bit, Lady Chatterley's Lover or a bit further, one of those 18th-century courtship novels whose potential to enervate young virgins was discernible, apparently, within just a few minutes of scholarly inspection.
How different for the mature student of Grand Theft Auto IV, who discovers that acquisition of the game, an Xbox 360 and a working television will not be nearly enough to expose the sickening extent of its moral bankruptcy. For that, you need time, skill, dedication and, I suspect, youth. In fact, it would probably be cheaper, and easier, for any averagely underqualified adult who craves the excitement of casual violence in a context of social indifference to make your way to somewhere like Borough Market and snarl: 'Out of the way, bitch' at every double buggy.
In fact, if a new book on gaming, Grand Theft Childhood: The Surprising Truth about Violent Video Games, is to be believed, there may exist hardly anyone in sound mind who might not, from time to stressful time, benefit from an hour or two of moderately violent gaming. The authors, two Harvard psychiatrists, Lawrence Kutner and Cheryl K Olson, were told by many young players that they played violent games to 'relax' or to 'get my anger out'. Should we not, as a matter of urgency, implore Gordon Brown to escape into GTA IV over the bank holiday? Or would the experience make an already vulnerable and solitary Prime Minister more likely to aim his car, à la Niko, at cyclists such as David Cameron?


text: Let Britannia take you back to nature, Norwegian Fjord style Spectacular scenery, enchanting towns, ancient cities and so much more. Many believe the only way to truly appreciate the breathtaking scenery of the Norwegian Fjords is to sail through them. We, of course, agree. Cruise in supreme comfort and enjoy a front-row view of one of the world's most wonderful regions. Settle into the pace of cruise life and enjoy the delights of Britannia as you sail from Southampton to Stavanger. The 'Cradle of the Vikings' boasts a charming old town with wooden houses and cobbled streets. In Flåm, you can ride one of the most scenic railways in the world. Have your camera at the ready for awe-inspiring views of thundering waterfalls and sky-high mountains. Next, you'll cruise through beautiful Aurlandsfjord and Sognefjord before arriving in the peaceful village of Olden. From here you can visit the vast, ancient Briksdal Glacier, which cascades down a mountainside and glows in several shades of blue. Your final call is picturesque Bergen. See the many historic sites on foot, or perhaps on a Segway tour, and pop into the Magic Ice bar for a seriously cool cocktail. Then, enjoy a relaxing sailing home.


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Bristol: now's your chance
The Bristol Planning Commission took a welcome stance last week when it staked out a more thorough process to solicit public comment on gravel and resource extraction that would be included in its revised town plan. The revisions have been ongoing for the past couple of years and the planning commission hopes to have the proposed draft completed for selectboard review this fall. It has finally put a full-court press on gathering public opinion on this controversial topic — but, hey, better late than never.The gravel extraction ordinance specifically falls under Section 526 in of the town's zoning ordinances (as distinct from the town plan) and would require a rewrite of this ordinance, but the hope is that public approval would be reflected in more generic wording within the town plan, as well, so both documents reflected the public will.But getting an accurate sense of the public will on the topic has not been easy. Throughout the past couple of years, an active group of opponents has shadowed the issue at numerous public hearings and have circulated a petition opposing a gravel pit that was proposed near the village center. Even a town survey indicated that a gravel pit too close to the town center was not acceptable, while the general public did agree that gravel extraction should be allowed within the town.At its Tuesday meeting last week, Planning Commission Chairman Tom Wells noted that the commission had invited gravel pit owners (and others involved in the extraction business) to review an early release of a draft gravel extraction ordinance several weeks ago, but had not heard from the general public on the revised ordinance they had proposed. For that reason, he said, the commission was making a special effort to solicit comments from the general public."We've had a great deal of great input from the pit owners," Wells said, concerning their draft ordinance. "We need to make an effort to make sure that the people who don't feel so strongly about the pits get an opportunity to come and talk to us as well. We need to hear everybody so that we can reach our conclusions."Among the ways to solicit that input will be putting the draft extraction ordinance on the town's Web site; setting up suggestion boxes around Bristol and reaching out to more individuals in town in various ways. Residents will have until Sept. 1 to comment, at which time the commission will convene again to take up the issue.We encourage residents to take advantage of this opportunity and let the commission know precisely how you feel. What are the options? Here are a few: • Residents who have been opposed to gravel extraction at the proposed Lathrop site, could oppose gravel extraction in districts that would be too near the town center for aesthetic, noise or traffic considerations. They could suggest that the zoning districts in the immediate downtown and core residential areas, including the two mixed zones that are within the village's core residential/business districts nearest the downtown, be excluded from gravel extraction. This follows the draft plan fairly closely, but adds the suggested mixed districts, which would include the proposed Lathrop site and the former Autumn Harp site.• Residents could read the draft and think it was fine, even though gravel extraction would be allowed at the proposed Lathrop site as well as in the other mixed zone surrounded by residential houses that was formerly occupied by Autumn Harp.• Residents could take the approach favored by those in the gravel extraction business that no limits be put on gravel extraction within a specific ordinance, but rather limit gravel extraction permits through the conditional use process. That allows all districts within the town to be open to resource extraction, but would be subject to specific limitations codified in how the zoning board of adjustment decides to define the conditional use restrictions at the time.• Or any other scenario that might be contemplated.We favor the first scenario, in which the specific districts of the core village area are excluded — including the mixed use districts — with conditional use permits applicable to allowing resource extraction in the remaining zoning districts within the town. (Note: there is no definitive terminology in the plan as 'core village' as used by some opponents, but the idea is obvious — it would include the downtown, the primary village residential areas, and the two mixed-used districts closest to the downtown/village center.)But others options make equally good sense depending on one's personal perspective. We encourage all residents to take advantage of this opportunity to comment either by directly responding to town officials, by sending comments to this newspaper, or by participating in future polls. But put your opinion in writing, one way or the other. It's a more forceful and accurate way for commission members to get an idea of precisely how the public wants the commission to proceed. It is the public's plan, after all, and commission members need residents' feedback before they can reflect those wishes correctly.


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The key element in the design of this set of parameters for loss of attachment with gingival recession is the professional judgment of the attending dentist, for a specific patient, at a specific time.
The patient's chief complaint, concerns and expectations should be considered by the dentist.
Following oral evaluation (see limited, comprehensive, periodic, detailed and extensive evaluation parameters) and consideration of the patient's needs, the dentist should provide the patient with information about gingival recession prior to obtaining consent for further treatment. (See: Periodontal Screening and Recording® (PSR®): An Early Detection System Q & A.)
The dental and medical histories should be considered by the dentist to identify medications and predisposing conditions that may affect the prognosis, progression and management of gingival recession.
Following oral evaluation, treatment priority should be given to the management of pain, infection, traumatic injuries or other emergency conditions.
Factors affecting the patient's speech, function and orofacial aesthetics should be considered by the dentist in developing a treatment plan.
In developing a treatment plan, the dentist should consider that the etiology of gingival recession can be multifactorial.
The relationship of the mucogingival junction to the marginal tissue, and the probing depth should be noted and considered in developing a treatment plan.
The behavioral, psychological, anatomical, developmental and physiological limitations of the patient should be considered by the dentist in developing the treatment plan.
Restorative implications, carious lesions, pulpal/endodontic status, tooth position, and periodontal status and prognosis should be considered in developing a treatment plan.
When the dentist considers it necessary, (an)other health professional(s) should be consulted to acquire additional information.
After consideration of the individual circumstances, the dentist should decide whether the gingival recession should be monitored or treated.
The dentist should recommend treatment; present treatment options, if any; and discuss the probable benefits, prognosis, limitations and risks associated with treatment, and the probable consequences of no treatment.
The dentist should refer the patient to (an) other health professional(s) when the dentist determines that it is in the best interest of the patient.
Relevant and appropriate information about the patient and any coordinated treatment should be communicated and coordinated between the referring dentist and the health professional(s) accepting the referral.
Medications should be prescribed, modified and/or administered for dental patients whose known conditions would affect or be affected by dental treatment provided without the medication or its modification. The dentist should consult with the prescribing health care professional(s) before modifying medications being taken by the patient for known conditions. (See: ADA Statement on Antibiotic Prophylaxis, Prevention of Bacterial Endocarditis: A Statement for the Dental Profession (PDF), and A-Z Topic: Antibiotic Prophylaxis.)
When recommending treatment, the dentist should recognize that gingival recession can be generalized or site-specific, progressive and predisposing to other conditions.
The dentist may counsel the patient concerning the potential effects of the patient's health condition, medication use, and behaviors and/or habits on his or her oral health. (See: Statement on Intraoral/Perioral Piercing.)
Any treatment performed should be with the concurrence of the patient and the dentist. If the patient insists upon treatment not considered by the dentist to be beneficial for the patient, the dentist may decline to provide treatment. If the patient insists upon treatment considered by the dentist to be harmful to the patient, the dentist should decline to provide treatment.
The dentist should emphasize the prevention and early detection of oral diseases through patient education in preventive oral health practices.
The dentist should determine the frequency and type of preventive treatment, based on the patient's risk factors or presence of oral disease.
The dentist should consider the characteristics and requirements of each patient in selecting material(s) and treatment(s).
The dentist should consider the compatibility of the selected treatment with the surrounding oral tissues and should provide an environment accessible for maintenance.
The dentist should attempt to manage the patient's pain, anxiety and behavior during treatment to facilitate safety, efficiency and patient cooperation. (See: ADA Policy Statement: The Use of Sedation and General Anesthesia by Dentists and Guidelines for the Use of Sedation and General Anesthesia by Dentists.)
Local etiologic factors should be removed.
Chemotherapeutic agents may be used by the dentist to facilitate treatment.
Alteration of tooth morphology and/or position; placement of restorations; modification or replacement of restorations; and treatment of carious lesions may be performed by the dentist to facilitate treatment or reduce symptoms.
The dentist may modify occluding, articulating, adjacent or approximating teeth to facilitate treatment.
Transitional or provisional restorations may be utilized by the dentist to facilitate treatment.
Teeth may be removed, as determined by the dentist. When appropriate, the patient should be informed of the necessity to replace any removed teeth.
Occlusal guards and/or splinting may be used by the dentist.
Root planing may be performed.
Regenerative, recontouring and/or augmentation procedures may be performed by the dentist.
Root resection and endodontic treatment may be performed by the dentist.
The dentist should inform the patient that he or she should participate in a prescribed program of continuing care to allow the dentist to evaluate the effectiveness of the treatment provided and the status of the periodontium.
The patient should be informed that the success of the treatment is often dependent upon patient compliance with home care instructions and recommendations for behavioral modifications. Lack of compliance should be recorded.
Documentation of treatment provided, counseling and recommended preventive measures, as well as consultations with and referrals to other health care professionals should be included in the patient's dental record.


text: NEW YORK (MarketWatch) -- Analysts at J.P. Morgan Chase & Co. on Monday upgraded Hewlett-Packard Co. HPQ, +1.28% to neutral from underweight and raised Fusion-io Inc. fio to overweight from neutral. "With HP, our view is that the headline news just cannot get much worse," the analysts wrote in a note. "As for Fusion-io, our research points to Fusion-io continuing to hold the pole position in server-side data acceleration technology." The J.P. Morgan analysts also downgraded IBM IBM, +1.65% to neutral from overweight, saying they were concerned that "investors could become less interested in the stock, given the company's limited upside potential and muted revenue growth profile at a time when broader tech end markets could be bottoming." J.P. Morgan also downgraded EMC Corp. EMC, +2.65% to neutral from overweight.


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Can Anesthesia Cause Future Memory Loss?
We have a dilemma. My husband has pdeudocholinesterase defic., and difficulty intubating. However, 2 yrs ago they overcame that because we knew in advance. So he had emergency quad by-pass surgery and then a year later emergency gallbladder (gangrenous) removal.
That was a year ago. His memory and cognitive ability decreased significantly and the neurologist relates it to post pump syndrome from the heart surgery as well as general anesthesia. (my husband did have 2 hips repl. under spinal) This neurologist said he strongly recommends not having any more general anesthesia unless it`s life threatening. Well, after the gallbladder surgery last year, he developed a hernia in the umbilical area. We have put it off for a year because of the anesthesia problem, but it`s getting larger. Today the surgeon said it`s still elective at this point, but because of the size and location it can`t be done without general anesthesia. He said as it gets bigger it could create a more difficult surgery in the future.
Dilemma? Have it repaired and risk more cognitive problems (he can still drive, handle money, etc. but concerned about any future memory/cogn loss) or wait? Don`t know where to turn…. Thanks
Quite a dilemma for you.
The cause of postoperative cognitive dysfunction is unresolved. It is clearly something that happens in a significant number of elderly patients. What is not clear is whether there is a connection between POCD and general anesthesia. One study which compared the incidence of POCD in patients who had regional anesthesia vs. general anesthesia found no difference. It may be the state of inflammation associated with tissue injury and healing that causes the problem, not the anesthesia.
Cardiac surgery is a special case. During bypass (heart-lung machine) a unique set of conditions are created, that may include lower blood pressure, lower hemoglobin concentrations, inflammation cause by trauma to blood cells passing through the machine and circuit, and emboli (tiny particles) dislodged from the aorta and passing to the brain. This causes a much higher rate of neuro-psychologic compromise than any other surgery, including hernia operations.
Removal of a gangrenous gall bladder is also a major insult to the body. Some patients with this condition are very sick indeed. So this may, once more, be a condition more likely than others to cause brain problems.
There is one (controversial) study showing greater long term problems – even mortality – in patients who have prolonged, deep anesthesia. So your husband may get the best results in terms of avoiding memory and cognitive problems from a quick operation by a really skillful surgeon, and using careful monitoring of the depth of anesthesia. Regional anesthesia is an intuitively attractive option, but, as stated above, there is no study evidence of less problems, and regional may or may not be possible depending on the location and extent of the surgery.
It would be helpful to pay attention to all other factors that might help with recovery, such as proper treatment of background conditions like diabetes and high blood pressure, stopping smoking or alcohol abuse, getting adequate nutrition, etc.
Hope this helps you to weigh up the risks and benefits of proceeding with surgery. Also a good idea to talk directly with your anesthesiologist ahead of time.
For more information:
Go to the Anesthesia health topic.


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Basically, after 4-0 4-0 and now this defeat at home after a long while, surely the water has gone above the nose and some serious introspection is needed.
What changes will you make to the side in general ? And also surely some structural changes to the domestic setup for tests is warranted now ?
Firstly, i'll begin by saying i'd sack Dhoni and Fletcher both. Dhoni is done as a test captain now and Fletcher has added zilch to the team. Yesterday morning session perfectly summed up the planning at the moment.
Then Sachin should probably call it a day, if not before then after the Australia series. (There i said it for the first time ever ). It pained me to watch him during this series and many young batsman are waiting in the wings.
The 2 openers have been **** and inconsistent for a while, and also their attitude hasn't been great particularly Sehwag's. Would drop them both to send a message.
In terms of bowling there are really not many options at the moment. Need Yadav and PK back fit, and Zaheer firing though he maybe past it.
Ashwin though has done with the bat might have to go too, as he is still too blunt against good batting lineups. Though that's probably a 50-50.