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A discussion about this on another forum got me thinking. Hypothetically, if the physiological effects of alcohol were not present, would people still enjoy drinking alcoholic beverages? Surely yes, now that we've been conditioned to like it. But I wonder if we found a sample of people raised in a non-alcohol-philic society (assuming there is one), and presented them with a variety of alcoholic beverages, they would enjoy any of them. Whatever they decide, is it despite the taste of alcohol, or because of it?
My guess is they wouldn't enjoy it. Alcohol is poison to us (and most other organisms as far as I know), right? So it would be only natural for us to find the taste offensive.
But on the other hand, fermented beverages also last because of that very same reason. And many people unknowingly took advantage of that fact to preserve beverages - wine, beer, etc. So maybe over the millennia of surviving on alcohol, we (or certain populations) have grown a penchant for it?
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hmm...wonder who was behind that idea...
"Wine's magic health-minded ingredients come from the skin of the grape. Resveratrol protects the body's cells, keeping them young and strong. Saponins bind to bad cholesterol and usher it out of the body. And flavonoids interfere with the multiplication of cancer cells."
Red wine is supposedly more beneficial than white. With the ever increasing liquor store prices, my doctor telling me it was probably a good thing to drink a glass or two a day, and having a nice spot to plant a vineyard it only made sense to put some vinifera in the ground.
Landot Noir
I enjoy the taste of well made vino. Dry ones that is. And they do go GREAT with food!
Praise Dionysus and Bacchus!!!!
Animals, such as elephants and moose (like the one who got caught in a tree this week) imbibe alcohol. Either they like the taste or it doesn't discourage them because they tend to return yearly for more fermenting fruit to indulge in.
I enjoy certain alcohol drinks even not aiming to get drunk. A slightly chilled beer with dinner is quite good. It seems to add to the filling part of dinner. Maybe it's just me but drinking a beer vs pop with the same meal, beer fills me quite more and tends to help me take fewer servings. A good wine for a special occasion like Thanksgiving also suites me. As does a good cigar and a toast shot for bigger events (graduation, wedding, occasionally a round of golf haha). As for energy/alcohol drinks, shots and drinks with 'fun' names. I'll pass. I feel like if alcohol didn't have the intoxicating effects it did you wouldn't see nearly the market but you would still see people drinking occasionally, dinner ect... Don't get me wrong I do drink socially and get drunk but when I do it's still the drinks I would drink with dinner.
I have never been a drinker except for my 21st birthday, and once in the 20 years since then. To me, anything fermented tastes rotten and disgusting, and I have to force myself to not gag if, for some bizarre reason I try to taste it. Anything distilled tastes like industrial solvents, and is about as pleasing to drink as paint thinner. In addition, my metabolism reacts very strangely; it takes huge volumes to affect me, and the buzz fades in minutes. Not much point in drinking for me.
I'm probably atypical, so I don't know how much use my two cents is worth.
It is an acquired taste… as is the taste of vegetables to most children (and a good number of adults). Many of us have been conditioned to like bustle sprouts and other arguably objectionable tastes.
I'd argue that everything is an acquired taste; we just acquire some tastes faster than others or some not at all.
As long as someone finds objection to a taste, anything can be substituted for alcohol in your question.
To address the specific question: yes, I actually like the taste of beer (and alcoholic beverages.) I don't drink to get drunk and I'm willing to spend money on craft beer and fine liquor simply because they taste good.
If I were to drink just for an altered perception, there are many less expensive options available that produce the results without any of the satisfaction.
I was raised in a Baptist "non-alcohol-philic society". We never had any alcohol in the house. The church that we went to was a "dry" church. No one drank alcohol. (I found out later that was not entirely true.) My mom is 85 and she's never had any alcohol in her entire life. I didn't drink until I was 21. I'm 59 now.
I don't have any understanding how people can stand the taste of hard liquor. I can just barely tolerate the taste of beer. Wine and champaign are not much better. I got shit-faced drunk three or four times when I was in my twenties. That was about the extent of my driking. I will have an occasional drink at social occasions but I don't keep any alcohol in the house.
I didn't drink coffee until I was 40. At the time I thought that the taste was nearly as bad a alcohol. But I've developed a taste for it now. I always look forward to a fresh brewed cup when I get to work in the morning.
I have three sons who are in their 20's. They all used to hate coffee. But two of them have been seduced by it's flavorful aroma. The third still won't drink it.
Love the smell of coffee...just smelling it gives me a high (little worrying, so I don't drink it much). I hate the taste of coffee though...thank commercialism for Starbucks' Frap's. I'm just as repulsed by the taste and smell of alcohol but haven't found a good mixed drink to mask it...
I think the majority of people wouldn't take to alcohol just for the taste, except perhaps those in adulthood. Once your tastes mature, you've burned away some of your more delicate taste buds, or you get bored with the normal fare, new things begin to appeal to you.
I love alcoholic drinks but not alcohol per se, although I like the taste of alcohol in the background. No, it's not just the buzz. But a glass of vodka, much less pure alcohol (which might be caustic)...no.


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In Defense of Your Racist Sexist Uncle
We are a nation divided, and we are antsy about inviting those divisions into our homes, on the nuclear level, as we connect with our families for holiday feasts.
Mostly, it seems, we are nervous about our racist, sexist old uncles.
"America needs Obamacare like Nancy Pelosi needs a Halloween mask!"
We wish they'd go away, letting us enjoy the undercooked poultry and over-sugared ambrosia in some semblance of utopian progressive peace.
But let me tell you why that's a terrible idea, America. Why you need your racist, sexist old uncle.
First, your racist sexist old uncle focuses your anger on the right things. Let's face it: As socially liberal as you are, you will always find some reason to freak the fuck out on your family at the holidays. Holidays are stressful. They cost a lot. The weather sucks. The travel is hard. And at the end of it, there is your mother, offering unconditional love and advice on how to care for her beloved grandchild, your obvious neglect of whom has caused the flu in her, and that's okay, because Nanna has drawn an ice bath with mustard seeds, because that's how the Amish did it, and it was good enough for them, and of course you couldn't know that.
What, you don't like unconditional love?
If it's not your parents, it's your in-laws. Who may be perfectly lovely to you, but have been keenly selected by nature and Darwin's big brain to guarantee maximum shit-loss by your significant other from now until the Mummer's Parade.
If you had no racist, sexist uncle, these perils would be more immediate. The holiday conversation might border on the minutiae of domesticity — your baby is so big! The yams are so big! Would you like to see Dad's photos of our big Cozumel cruise? This ancient pyramid with these trinket-hawking natives is so big!
All the time, there would be no acknowledgement whatsoever of the fateful role in our lives played by Obamacare, Benghazi, Trayvon Martin, FEMA camps, the Fed, and those sorority girls with their silly accusations. You might be forced to acknowledge the gaping canyon of nothingness that stands between you and the alien zephyr of life that animates these blood relations, these strange meat sticks whom society holds up as the biological and ethical raison d'être of your person-ness.
Fuck that. Your racist, sexist uncle is throwing you a lifesaver. Don't let yourself drown in a turbid sea of Updikean suburban malaise. Seek refuge in your racist, sexist uncle's miasma of burped-up Jameson and slutty Italian jokes, the only thing that broke his six-month catatonia after Wife No. 3 went down the shore to Brigantine and never came back.
"What do you call an Italian hooker? A pastatute!"
He is a sacrificial anode, your racist sexist old uncle is. Absent his intervention, we would be pitted and wasted away by the smaller destructive forces of the holiday season.
But beyond the blessed distraction that he provides you in his grace, your racist, sexist uncle makes you a better person, engaging you in an elaborate staged mimesis of the Hegelian master-slave dialectic. For if there is no racist, sexist uncle, then there is no comparative challenge, no middling standard of ugliness, against which to prove your culturally enlightened nature. Without the counterpoint of his rusted-out V8 Firebird with the "NO FAT CHICKS" bumper sticker, your low-emissions Subaru with the "YES WE CAN" magnet is just another car in the jammed-up driveway.
"What do you call two blacks on one bike? ORGANIZED CRIME."
Your racist, sexist uncle is the oval track, and you are the sprinter. Your racist, sexist uncle is the bench-press bar, and you are the lifter. He is the open journal, and you are the pen. You are a master of your fate, of the dictates of racial and gender politeness, only because your other family members can see the reductio ad absurdum of their bigotry in your combed-over foil across the table, sitting there stuffed in a disintegrating Bill Blass dress shirt that Wife No. 2 bought him in the now-defunct Wanamaker's for $8.95.
You sit, a paragon of yoga-loving, organic-banana-mashing-for-the-baby virtue, proving once and for all that, no, Obama is NOT a FUCKING Kenyan, all because he allows you to profess it as he strokes his mustache, the one he calls his "pussy tickler."
How strong is your racist sexist uncle? He is strong like a deceptively named yellow dwarf star, held together by his own gravity, miraculously never collapsing under the internal pressure, keeping us all in his orbit, preventing the rest of us celestial bodies from colliding into each other. If the cost of this is that he tosses off an occasional toxic cloud of gas, or flares up in nobody's particular direction, so be it. We only come around him once every year or so.
Admit it: You envy your racist, sexist old uncle's strength. The tenacity with which he clings to tenuous untruths. His eagerness to ingest your abuse. His ability to say it all, take it all, and afterward, quietly leave your infant child a hundred-dollar bill and a Dave and Buster's gift certificate downstairs, then to leave a six-foot shriek of sheet-metal scratches on the side of your car as he drunkenly pilots his "pussywagon" home.
Why must you love your racist sexist old uncle? Because he can take it, all of it. And so can you.


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Nelson International
Nelson International is a heavy duty truck dealer servicing all of North Dakota and Western Minnesota. In all of their locations, you are able to buy all makes heavy duty truck parts or get your truck serviced. They are a full service heavy duty truck dealers that also provides heavy duty truck sales and leasing. You will find a large selection of Navistar International brand trucks as well as some other used lines. They are willing and able to provide second-to-none truck service in Fargo, Bismarck, Willmar and Dickinson.
In our opinion, Nelson International is the best place to buy a truck or truck parts in Minnesota and North Dakota.
Thanks for reading


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Updated. Occupy London – Following Legal Threat from TfL; Crowdsources New Logo
NB. Occupy London has just received the following from Evershed LLP on behalf of Transport for London. We would ask that people take note.
Dear Sirs
We wrote to you on 10 November regarding your use of the TfL Roundel as part of the logo for Occupy London. TfL was appreciative that you quickly arranged for the design and use of a new logo (as seen, for example, on your Facebook page). However, TfL has been coming across an increased use of the Roundel in association with Occupy London. It may be that such use is inadvertent but TfL would be grateful if you would continue to ensure that there is no use of the Roundel (or any similar variation) in relation to the Occupy London campaign.
Yours faithfully
Eversheds LLP
Occupy London – Following Legal Threat from TfL; Crowdsources New Logo
Following a legal threat from Transport for London's lawyers, Eversheds LLP, on Thursday 10th November, Occupy London has changed the logo – very loosely based on the Transport for London roundel – that it had been using across its website and social media presence.
The move follows the threat of potential legal action from TfL's lawyers, Eversheds LLP, when on Wednesday 9th November, Occupy London was requested by email to change its logo immediately or risk losing its facebook page – an essential means of communication for the occupation, which currently has over 30,000 supporters on the social network. [1]
Occupy London supporter James Hughes commented: "As a gesture of goodwill, Occupy London has acceded to TfL's request. We appreciate that, in these straightened times, public bodies need to safeguard income. We trust that TfL managment will be as understanding of the needs of ordinary commuters who have been continually facing rises in their transport costs."
The TfL logo, originally commissioned in 1903, has been used on London's transportation systems since 1908, becoming synonymous with the city itself. [2]
Eversheds wrote in its email: "If we do not receive a response by noon tomorrow, TfL will liaise with Facebook in order to seek the removal of the version of the Roundel being used on that site (at facebook.com/occupylondon). Please note that once Facebook is on notice that you are infringing TfL's rights, it may decide to take down your Facebook page in its entirety."
Occupy London has said that it appreciates that TfL wishes to be seen as neutral and it has said that is "not looking to disrupt your campaign." Occupy London hopes that TFL would put up defiant resistance to any kind of political interference, be it in relation to its campaign, or any other.
Occupy London crowdsources new logo
As such Occupy London has decided to crowdsource a new logo, which will be decided through a process of online direct democracy. Supporters are now invited to get involved and the following list of criteria for the new logo has been agreed:
- Originality: Needs to be original. Images based on existing corporate logos or any variations thereof cannot be used.
- Key messages: Needs to reflect what the Occupy movement stands for. Some key words that might help: Democracy, Equality, 99%, London, Global Movement, Occupy.
- Colours: We welcome any colour combination, but it should also look good in black and white, so that it can used on different coloured backgrounds.
- Neutrality: It cannot resemble the imagery of any political party or similar institution.
- File formats: Submissions are requested in two formats, as an esp. and as a high-resolution jpeg.
Submissions are welcome at firstname.lastname@example.com. For further information on design or submissions, please visit http://occupylsx.org/?p=932.
[1] "Dear Sirs
We act for Transport for London ("TfL") and we are writing in relation to your ongoing use of a version of TfL's Red and Blue Roundel as part of the "Occupy London" campaign ("the Roundel"). This includes the use on your website at www./occupylondon.org.uk and on your Facebook page at facebook.com/occupylondon.
"TfL has already been in contact with you on 20 October and 28 October in an effort to resolve this matter amicably. Unfortunately, TfL has not had any response (or even an acknowledgement) to its requests so far and it is disappointed that you seem unwilling to deal with this issue in a sensible way. TfL is not looking to disrupt your campaign but it has legitimate concerns which need to be addressed in order to avoid the need for further action.
"In short, and as already explained, because of TfL's rights in the Roundel and because it is a public funded and non-political body which cannot promote or endorse your campaign, you now need to cease using the Roundel and adopt a new logo.
"Please confirm by return that you will cease using the Roundel (or any similar variation) in relation to the Occupy London campaign including, without limitation, on your website and Facebook pages.
If we do not receive a response by noon tomorrow, TfL will liaise with Facebook in order to seek the removal of the version of the Roundel being used on that site (at facebook.com/occupylondon). Please note that once Facebook is on notice that you are infringing TfL's rights, it may decide to take down your Facebook page in its entirety. We therefore suggest that you arrange for the relevant pages to be changed voluntarily and in order that this can be resolved amicably.
"Yours faithfully
"Eversheds LLP"
[2] The design has undergone a number of revamps over the years, but the version Occupy London took very loose influence from has been in regular use for at least 64 years, following the nationalisation of the London underground system in 1947. Harold Hutchinson, who was responsible for that particular refinement of the logo, did that work as the Publicity Director of a nationalised public corporation; a public servant paid out of the public purse.


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Find Our Latest Video Reviews on YouTube!
If you want to stay on top of all of our video reviews of the latest tech, be sure to check out and subscribe to the Gear Live YouTube channel, hosted by Andru Edwards! It's free!
Tuesday May 26, 2009 1:19 pm
Toddler Buys Excavator Online
Posted by Sheila Franklin Categories: Internet, PC / Laptop
A couple in New Zealand woke up one morning only to discover that their 3 year-old had accidentally bought a $NZ20,000 Industrial Excavator from the site Trade Me. Mother Sarah Quinlan said that she had received an email from them saying that they hope she loved the mechanical digger. Claiming her daughter doesn't even like tractors, she managed to convince the seller to take it back. Daughter Pipi has been banned from the computer when alone and her parents removed their auto-login. We think that is one precocious little girl and can't wait to see what she can do once she is old enough to have her own.
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Check in via our website up to 36 hours before the departure of your flight. Online booking terminates 1 hour before the departure.
Web Check-in
If you travel with cabin baggage only, you can check-in for your flight on our website, print your boarding pass and proceed directly to security screening after arrival at the airport.
If you travel with checked baggage, it is necessary to first drop the baggage off at the assigned airport desk.
The online check-in service is available on all regular scheduled Czech Airlines operated flights (the OK 0001 - OK 2999 flights).
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If you are denied boarding or if your flight is cancelled or delayed by two hours at a minimum, ask the check-in counter or boarding gate agents for the text stating your rights, particularly with regard to compensation and assistance. Detailed information is available at the European Parliament Directive No. 261/2004.
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The web check-in service and the service of check-in via our mobile applications are available at all destinations serviced by Czech Airlines regular scheduled flights with the following exceptions:
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Support the Glass Message Board by finding a book via book-seek.com
Support the Glass Message Board by finding glass through glass-seek.com
Ivo, I have to ask, what Danish book are you referring to. I am really lacking in books on Scandinavian glass. Terry
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If only the country paid as much attention to health care safety as to aviation safety. Plane crashes have become rare because the airline industry changed its culture to put safety first. In health care, however, patient safety does not get the attention it deserves. Too many patients die every day from avoidable mistakes.
The airline industry is in turmoil about the grounding of the Boeing 787 Dreamliner. The Federal Aviation Administration took pre-emptive action because of fears that the lithium batteries could overheat and cause fires. Although no plane has crashed and no one has died, Dreamliners won't fly until this problem is resolved.
If only the country paid as much attention to health care safety as to aviation safety. Plane crashes have become rare because the airline industry changed its culture to put safety first.
In health care, however, patient safety does not get the attention it deserves. Too many patients die every day from avoidable mistakes. Some experts estimate that the death count is equivalent to three jumbo jets crashing every day. Because TV cameras do not capture the carnage of health care errors, the problem is invisible.
It shouldn't be. A study published in the medical journal Surgery (online, Dec. 18, 2012) analyzed so-called "never events" — things that are never supposed to happen, like an operation on the wrong body part or the wrong patient. Leaving an instrument in the patient at the close of an operation is another type of never event.
The authors analyzed malpractice cases between 1990 and 2010. They concluded, "Surgical never events are costly to the health-care system and are associated with serious harm to patients."
It seems to us that 21st-
century hospitals should have systems in place to prevent such mistakes. Some do; nevertheless, roughly 40 times a week in the U.S. a sponge or a towel is left inside a patient. About 20 times a week the wrong side or the wrong body part is operated on. And the wrong operation is performed about as often. At least 4,000 never events occur in the U.S. each year. That is just the tip of the iceberg. Many such events don't make it to a malpractice case.
One reason is that medical errors aren't often disclosed. There is no mandatory reporting system, and voluntary reporting falls short. A recent study of medication error reporting in hospitals concluded that, "When errors occur, patients and their caregivers are rarely informed" (Critical Care Medicine online, Dec. 20, 2012).
Most hospitals have an official policy encouraging physicians and other health care providers to tell patients and families about errors. But in this recent study, barely 2 percent of medication mistakes were revealed.
If a pilot makes an error or has a "near miss," that must be reported immediately. Such events are used by the entire industry to avoid similar problems and improve aviation safety. Health care has no similar system, so mistakes are repeated in hospitals around the country.
This is why patients and their families must be on guard against likely errors, whether in the doctor's office or the operating suite. To learn more about how to protect your loved ones, you may want to read our book "Top Screwups Doctors Make and How to Avoid Them." It is available in bookstores, libraries and online at www.PeoplesPharmacy.com.
Patient vigilance can go only so far. We look forward to the day when going to the hospital will be as safe as getting on a plane.
Write to Joe and Teresa Graedon via their website: www.PeoplesPharmacy.com.


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This fluorescent (FITC)-labeled TAT peptide contains a long chain (LC) to prevent FITC from degradation. Abs/Em = 493/522 nm.


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Vivian Daniels could serve as inspiration for the famous tongue-twister about sea shells and seashores.
Vivian Daniels could serve as inspiration for the famous tongue-twister about sea shells and seashores.
The 72-year-old resident at Our Home at Beacon Hill has made a name for herself selling creations made from sea shells found on the nearby beach.
Daniels collects anything she can find in the sand and turns the items into works of art.
Using shells of all types she creates flowers, turtles, bouquets, picture frames, pencil holders, soap dishes, flower pots and magnets.
�Vivian collects shells, separates them and creates these amazing things,� said Rick Watkins, administrator at the facility. �She has an incredible creative ability.�
To date, Daniels has arranged and put together hundreds of sea shell flowers.
Her regiment includes washing her findings in a water/bleach mixture, giving them a coat of baby or mineral oil or spraying them with acrylic to prevent the shells from drying out or cracking.
�Shells have more color than you see at the beach,� said Daniels. �After you rub a little oil on them, the color bounces out at you.�
Daniels sells the items out of the activity room at Our Home at Beacon Hill and prices range from $1-$10 per item.
She then puts the money right back into purchasing additional supplies that can be used for activities at the facility. She believes that keeping busy is the key to a longer life.
�The facility is doing wonderful work, but we need more activities to stay happy and keep the residents moving,� said Daniels.
�I want to inspire the other residents. They can see that I have the determination to move and I can do things. I�m 72 years old and if I can do it, they can, too.�
Daniels didn�t always have the creative urge and said that one day as she was walking the beach, the idea simply struck her and couldn�t be ignored.
From that day on she collected shells on each visit to the white sands of the Gulf and would work on her art at night after the rest of her family had gone to bed.
While shell art may occupy her days now, Daniels didn�t start crafting her creations until she was in her 30�s. Prior creative activities included sewing clothes for her kids and teaching kindergarten for eight years at Faith Christian School in Port St. Joe.
Daniels� family moved to Gulf County when she was in the sixth grade and she spent her youth in Port St. Joe. She later moved to Alabama in 1982 where she remarried and lived until July of this year.
The sea shell seller is proud of her Gulf County heritage and said that her father, Emery, had a machine shop on First Street and worked with the paper mill and railroads.
Two of her brothers worked in the machine shop and her brother Jimmy, a former police officer, still lives in Jones Homestead with his wife. Daniel�s mother, Jean, was known in the community as �Miss Jeanie.�
Daniels admitted that Port St. Joe isn�t exactly how she remembered it and was saddened to see that U.S. Highway 98 had been moved inland.
She said that the area now occupied by WindMark Beach was where she used to find the best shells, especially since sea life would often be attracted to bits of asphalt that would fall into the water.
�I love to walk on the beach and see God�s creations,� said Daniels, who spends an hour or more on the beach each day collecting materials. �Each flower is a different experiment.
�It�s often a toss-up as to what it a shell will become. Most of the time, I have no earthly idea what I�m going to do with them.�
In addition to creating her random works of art, Daniels takes bulk orders and has been busy prepping shell-based Christmas ornaments for the holidays.
The goal was never to make money until Daniels decided to help fund more activities for her fellow residents.
If those activities come at the cost of Daniel�s art, she�s happy to help. She also praised activities director Tiffany Lee for the slew of Halloween-themed activities in recent weeks that included decorating pumpkins, masks and pennants.
Lee also instituted a �learn something new� program for the facility that included a first aid class and several sign language classes to help everyone communicate with one of the home�s deaf residents.
She has also started a walking club and takes the residents out to eat and on shopping trips at least once a month.
Daniels just hopes that buyers will put her creations on their coffee table or book shelf to add a little bit of nature inside their home.
�It�s not work--it�s a hobby and a pleasure,� promised Daniels. �It�s a labor of love.�


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Reverse Culture Shock: after a year amongst The Gays.
The World Traveler, Vagabond, the Best Friend you never see. That's been me for the better part of my adult life. Running, flying, biking around the world. Always someone new to meet, a new language to learn, a new site to see. Most comfortable when out of my element, at ease when stressed about a flight, peaceful when crammed into a bus seat.
This past (almost) year I have been living in the capital of the Midwest: Chicago. Close to home, and seen to be wholly without adventure. Not exotic the way my previous adoptive homes were. I was saddened as I wore out my travelers boots walking the streets of Chicago last winter. I hid them away in my closest not strong enough to throw them away and say good-bye to my wanderlust ways.
My favorite part of traveling and the part I assumed was gone, at least while I remained in Chicago, is immersing myself in a culture that is not my own. I enjoy learning the holidays and customs of another culture. I read history books about their past to better understand how they came to be the way I find them now. Being the chatter box that I am I will quickly start learning the language of my new community in order to better connect with those around me.
The move to Chicago was a spur of the moment decision. A place that wasn't suppose to have that weird adjustment period that comes with moving to a new country. With no money, no job, no friends, no family and no place to stay; Chicago actually proved one of the most difficult adjustment I had ever made. I had nothing and I knew it. I didn't even have the benefit of enjoying my passion for learning about new cultures, for I was in the midst of a culture that I already knew.
Midwestern Mentality: Check. I'm the daughter of a Midwestern Dairy Farmer. My Midwesterness is undeniable.
Big City Living: Check. Already lived in that crazy, wonderful, international city of Amsterdam.
Extremely Corrupt Government: Child please. Let's just say Kyrgyzstan and Uganda. Double check.
Only recently while experiencing reverse culture shock did I realize that I had found and become apart of a culture not my own. Without realizing it I had immersed myself in Gay Culture. I now speak fluent Fabulous. I have read numerous books and articles this past year about the Gay Rights movement in the United States and around the world. I have even participated in the Gay High Holy Days: Pride, Market Days, and Halloween.
This reverse culture shock came when I returned to a familiar place: the sports bar, a straight sports bar. A bar filled with hetero-normative behavior ...eerrrr… in a way guys in that bar would understand it was filled with Dudes.
Beer guzzling, whiskey shot taking, high fiving, chest bumping, backwards hat wearing Dudes. My people. My Dudes. Someone chest bump me now! I was in a room full of Lions fans(my favorite sports team) most of them Michigan State alumni (I myself am an alumna of that fine institution). Regular Dudes from Michigan have always been my specialty.
I can talk sports, especially Michigan sports. I LOVE beer. I'll do as many shots as you do and when you pass out in the corner I'll still be standing and suggesting that you buy me another one. These kind of guys have always loved me. They have been the ones I call to move my couch when I move. They are the ones who have helped me steal beer from the party next door when the party I'm at has run out. I have shot guns at cans with these guys. I know them.
Or so I thought.
Last Sunday I experienced the same feeling I had my first time back in an American grocery store after Kyrgyzstan, a bath after Uganda, or the first time I saw my friends sneak off to smoke a joint after coming back from Amsterdam. I was experiencing reverse culture shock. Being thrown back into the deep end of your own culture after an extended period away can sometimes be just as jarring as being ripped from your native culture and put into one you have never heard of. I suddenly found myself sitting back and observing instead of fully participating in the rituals of the sports bar. Dudes still high five, get aggressive for no reason, and the ubiquitous shot of whiskey was ever present.
It was me that was no longer present. I was in a daze trying to re-learn social patterns that I know I know. Then I found myself playing a new game in my mind. Spot the gay. Who is on the DL (Down Low) in the Sea of Dudes? This is similar to a game I play in Europe: spot the American. Not the obvious ones, not the ones like me that cannot blend in no matter how hard they try. No I like to find the ones that are trying their darndest to wear the right shoes, coat, and jaunty scarf but some how still read as American.
My bench on the side wall gave me a great panoramic view of the Sea of Dudes. My year of adventures amongst the Gays have trained my eyes to spot them even in the dimmest of lights. The way a lighthouse keeper's eye are trained to spot a ship in the distant horizon. Unsure if I was really spotting Gays in the Sea of Dudes or if they were just mirages I was relieved when a back up pair of eyes came in. My best friend here in Chicago, who happens to be gay, showed up. He picked off my potential targets immediately: chic scarf to the left of us, tight gray sweater at the bar, The over compensating dude at my table who when the Lions won in an amazing 98 yard run at the end of the game celebrated by rubbing the back of his "buddy." Sure Dude. Keep lifting weights, no one will ever think you're gay.
This reverse culture shock happened to me by going no further than walking distance from my apartment. The traveler mentality, my passion for people, and adventure aren't based on how far away from home I go. My return to hanging out with Dudes reminds me that I might need to start making time to occasionally Bro It Up so I don't have that shock again. Like all great travelers, even if I am staying in one city, I need connect with my ability to slide in and out of cultures with ease. Especially between my native culture and my adopted culture.
As I approach the year mark of me living in Chicago I get nervous. Should I make a run for it? I have enough money to get to… Wyoming. Maybe Idaho.
I don't stay places.
I leave before I can get left behind. Yet, something is keeping me here. I want to stay here. I want to develop very real and long term friendships. Not the surface friendships the constant traveler develops, the ones that keep you from being overtly lonely but are not intimate, deep, and lasting.
There in that straight Dude Bar, that I didn't know anymore, I felt like a traveler again but it also put in to perspective that I have some very real friendships here. I embraced by a community of people that are not my own but I have grown to love them and care about them, and gosh I hope they feel the same way. Right now I'm happy where I'm at, amongst the Gays. And if I ever need a jolt of culture shock and the travelers rush, Wrigleyville and bars full of Dudes are a short train ride away.


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i also help bands i like release records. below is a list of records i have been involved with past, present and future. there's been a lot of stuff along the way, and hopefully more to come.
i am interested in trades, though you should get an idea of the kind of stuff i carry from my releases below. i am definitely happy to sell your distro my stuff at wholesale rates! either way, get in touch through the contact form on the left.
If you'd like to be on the sncl mailing list for early updates of new releases and stock, please visit this page and sign up.
States of Nature - Collide-A-Scope 7"
C'est Dommage - Red Lobster 7"
Monplaisir - the Agreement 12" lp
City of Caterpillar - Driving Spain Up A Wall 12 EP
Bite Marks - s/t 12" EP
55 Deltic - You Could Own An American Home 12" lp
Coma Regalia - The Mirror 11" lp
Whaleheart - Younger Years 12" lp
v/a - X 12" lp


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Happy Day after Valentine's. Anyone else gorge themselves way too much on chocolate? I know that I did. I think that's the point of Valentine's Day. Right? Oh well if it's not. It's how we celebrate it.
I am loving looking at the love-filled layouts with this month's buffet, Listen to Your Heart. I picked from the Buffet Challenge gallery this week, and if you're wanting an "easy" challenge to do, this is definitely one for you!
Created by our own Spotlight Challenge host, Ambelleina. I have to giggle at the pictures. I love layouts that talk about why they love their significant other!


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Our mission is to provide users and associated guest with an effective single point of contact and responsive tracking of computing and information technology related queries.
The Helpdesk service is manned during normal working hours, at least between 09:00 until 17:00, however, although you may receive response outside these times, this can not be guaranteed. The service will not necessarily be fully staffed between 12:00 pm and 1:30 pm, if you submit a call during this period, please be patient. HelpDesk submissions and Mail calls sent during this period and those submitted outside working hours will be attended to at the earliest opportunity.
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Ogden News
Chemistry Club receives national award
- Author: Thursday, September 15th, 2011
For the ninth straight year, WKU's Chemistry Club has earned national recognition from the American Chemical Society.
WKU's American Chemical Society student chapter received a Commendable Award for its significant professional and service activities. Only 25 percent of all ACS student chapters receive an award.
Sarah Ward, a chemistry major from Glasgow, is serving her second year as chapter president. Dr. Les Pesterfield served as the faculty advisor in 2010-2011; Dr. Jeremy Maddox will serve as the faculty advisor this year.
Contact: Cathleen Webb, (270) 745-3786.
Some of the links on this page may require additional software to view.


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Here you can find How-To articles and the information you need to help you choose the right floor for your home or business and make an informed decision.
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Running Time: 232 minutes
Studio Name: Reality Kings
Series: Sneaky Sex
Categories: All Sex High Definition
Description: These slick fuckers are seconds from getting off, and moments from getting caught! That's the thrill! Nothings sexier or more fun than some Sneaky Sex!
6 Scenes from Sneaky Sex 2
Sneaky Sex 2: Scene 1 Free Preview
Starring: Tina Kay Ivana Sugar ... More Details
Stars: Tina Kay, Ivana Sugar
Sex Acts: Oral Sex, Deep Throating, Vaginal Sex, Voyeurism, Masturbation
Positions: Doggy Style, Kneeling, Laying, Reverse Cowgirl, Sitting, Standing, Standing Cowgirl, Standing Missionary, Standing Doggy Style, Standing Side Saddle
Settings: Bedroom
Sneaky Sex 2: Scene 2 Free Preview
Starring: Jaye Summers ... More Details
Stars: Jaye Summers
Sex Acts: Oral Sex, Deep Throating, Vaginal Sex
Positions: Standing Doggy Style, Cowgirl, Kneeling, Laying, Missionary, Reverse Cowgirl, Sitting, Standing
Sneaky Sex 2: Scene 3 Free Preview
Starring: Jade Amber ... More Details
Stars: Jade Amber
Sex Acts: Oral Sex, Vaginal Sex
Positions: Standing Doggy Style, Standing Side Saddle, Cowgirl, Missionary, Reverse Cowgirl, Sitting, Standing Missionary
Settings: Outdoors
Sneaky Sex 2: Scene 4 Free Preview
Starring: Dillion Harper ... More Details
Stars: Dillion Harper
Sex Acts: Oral Sex, Tittie Fucking, Deep Throating, Vaginal Sex, Masturbation, Food Play, Rim Job
Positions: Cowgirl, Laying, Reverse Cowgirl, Side Saddle, Sitting, Standing, Standing Missionary, Standing Doggy Style
Settings: Dining Room
Sneaky Sex 2: Scene 5 Free Preview
Starring: Stella Cox ... More Details
Stars: Stella Cox
Sex Acts: Oral Sex, Tittie Fucking, Deep Throating, Vaginal Sex, Masturbation
Positions: Cowgirl, Doggy Style, Kneeling, Missionary, Reverse Cowgirl, Sitting, Spoons position, Standing, Standing Doggy Style
Sneaky Sex 2: Scene 6 Free Preview
Starring: Alix Lynx ... More Details
Stars: Alix Lynx
Positions: Cowgirl, Doggy Style, Kneeling, Laying, Missionary, Reverse Cowgirl, Side Saddle, Standing, Standing Cowgirl
Recommended Movies


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Get Involved
This association wouldn't be what it is today without the volunteering efforts of it's members. Throughout the year, a number of volunteering opportunities come up that offer members the opportunity to lend a hand. Below is a list of volunteering opportunities that are available. If you are interested in helping in any of these areas, please call the office at (605) 361-8322.
The association has more than a dozen committees for members to join to get involved. Most meet once a month for only one hour while some meet less than that. Committee members are the ones who plan our events and hash out the details of various programs. Not sure which one to join? Check it out as a guest for the first month. Ask for a current list of committees to join today!
HBASE is actively working to increase programming opportunities for those interested in entering the home building industry as a career and to better connect various resources with students. Throughout the year, volunteers in the industry are needed to help further our efforts.
Builders - This is a great opportunity to meet the future workforce first hand and show them what job opportunities are available to them in the building industry.
Programs seeking volunteers:
- Summer Construction Camp (CTE)
- Career Fair Presenters
Sioux Empire Home Show
The Home Show is our association's largest event and would not be successful without the help of our VERY generous and hardworking members that volunteer their time over the 3-day period. Some volunteer positions include:
- Team Captains to mark booths
- Mark booths
- Carpet delivery
- Exhibitor set up
- Exhibitor check in
- Carpet layout
- Volunteer coordinators
- Ticket taker / door guards (arena entrance)
- Booth worker (door prize booth)
- Carpet removal
Parade of Homes (Spring and Fall)
The Spring and Fall Parade of Homes are a great opportunity for members to network with each other and the consumers. Various volunteer positions include:
- Feature Home Ticket Takers (when available)
- Sign Assembly (prepare yard and directional signs for Builders to pick up)
- Awards Category Split
Repair Affair Day™
This annual event is held June each year. During this one day event, Repair Affair volunteers help with accessiblity improvements and updates for income qualifying homeowners. This allows them to remain in their homes longer.


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Going to touch on a different kind of healing, a real kind. This video was linked to me when it was first released back in November, and it makes me smile every time I watch it or even just listen to the song.
What makes me extremely happy is to find that the artist of the song the hospital chose to use, "Down" by Jay Sean, said he was honored that they had chosen his song for such an important message, and he held a live concert, complete with pink gloves:
In the above vid, there's an interview with Jay Sean about the viral video.
Cancer has touched my extended family in many ways, including breast cancer. Cancer has touched my guild: we have a very special rank called "Remembered." Videos like these are inspirational for millions across the world: catch it early as possible, and fight it, fight it as hard as you can.
An update from me and closing my guides
1 year ago


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WASHINGTON - Beset by problems with the rollout of the president's health-care law, the Obama administration has canceled plans to allow small businesses in many states to use a website to select health-insurance plans for their employees for next year.
WASHINGTON � Beset by problems with the rollout of the president�s health-care law, the Obama administration has canceled plans to allow small businesses in many states to use a website to select health-insurance plans for their employees for next year.
Officials said they need to concentrate on fixing the website that allows individuals who do not get coverage at work to sign up for insurance.
Instead of a website, small employers in 35 states, including Ohio, will have to go through insurance brokers or deal directly with insurance companies to get a plan that meets new standards in the Affordable Care Act, as many already do.
Under Obamacare, most small businesses do not have to provide coverage. But firms with 50 or more employees face a mandate to offer insurance or risk fines from the government in 2015.
The HealthCare.gov site, where individuals without employer-sponsored health care can shop for insurance, is now smoothly handling 25,000 users at the same time and is on track to meet its goal of handling 50,000 simultaneous users by Saturday, said administration spokeswoman Julie Bataille. � We have a lot of work left to do in the next few days,� she said.
The administration�s announcement yesterday does not affect businesses in states such as California that are operating their own Obamacare marketplaces, many of which have been successfully enrolling people. And because small businesses still can sign up their workers through brokers, the lack of a website may not have a large short-term impact on coverage.
But the postponement marks another major setback for administration hopes to showcase the Affordable Care Act�s promise and to demonstrate an ability to implement the law effectively.
Republicans quickly pounced on the latest bad news.
�It�s another broken promise and more proof this administration�s assurances have no credibility,� said House Speaker John Boehner, R-West Chester. �This law has been an absolute disaster, leaving us to ask �what�s next?�??�
Administration officials said they hope that a website allowing small employers to shop among plans online will be operational by next November so that employers can shop for plans for 2015.
�It was important for us to prioritize the functionality that would enable consumers individually to shop and enroll online,� said Bataille, a spokeswoman for the Centers for Medicare and Medicaid Services, which is working on the websites.
The small-business marketplaces � known as the Small Business Health Options Program, or SHOP, exchanges � were supposed to offer small employers the online ability to compare health plans for their employees and select up to several options. But the SHOP marketplaces have been dogged by many of the same problems that led to the disastrous rollout of the online marketplaces for individual consumers.
�It�s disappointing,� said John Arensmeyer, CEO of Small Business Majority, which has supported the Affordable Care Act. �It�s important it get up and running as soon as possible.�
The National Retail Federation, which has worked to ease the law�s requirements, was less generous.
�If the law is so burdensome for the administration to implement, just think how hard it is for small businesses, which are focused on growing a company, hiring new employees and assisting customers,� said Neil Trautwein, the group�s top health-policy official.
Small businesses buying coverage still will be eligible for tax credits to bring down the cost, according to the administration. Starting next year, small businesses can claim a credit of up to 50 percent of their contributions to premiums for insurance purchased through the SHOP.
Information from the Associated Press was included in this story.


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Color-coded NM cable simplifies inventory management
Romex Extra Color NM-B is a line of nonmetallic cable color-coded by gauge size. No. 14 is white, No. 12 is yellow, No. 10 is orange and No. 6 is black. The colors simplify inventory management for distributors and provide easier installations for contractors. Southwire Co.
Do you think this product should be the 2002 Product of the Year? E-mail us your name, company name and phone number, along with the name of this product and manufacturer, to enter a drawing for a $100 American Express gift certificate.
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The large continental ice sheets shrank, and sea level rose.
Around 8,200 years ago, however, a major cooling event occurred.
The 8.2 ka event was first discovered in the Greenland ice core GISP2.
Over two decades temperature cooled about 3.3°C in Greenland.
Temperatures in Europe dropped by around 2°C.
The entire event lasted about 150 years.
Then temperatures warmed, returning to their previous levels.
Then temperatures warmed, returning to their previous levels.
So what caused the 8.2 ka event?
As the large ice sheets in Canada were melting, a large meltwater lake formed south of the Hudson Bay.
Geologists have named this Lake Agassiz, after the 19th century scientist Louis Agassiz.
Geologists have named this Lake Agassiz, after the 19th century scientist Louis Agassiz.
It was dammed to the north by the Laurentide ice sheet.
Slowly, the ice melted further, and the lake emptied into the sea in a very short period of time.
The release of the water from this ice-dammed lake into the ocean is recorded by sea-level jumps in the Mississippi and Rhine-Meuse deltas of approximately 0.4 and 2.1 metres.
The cold water flooding into the Atlantic caused cooling, and the rising sea level formed the North Sea and the English Channel, creating the familiar shape of Britain.
This event shows that the climate can react strongly to sudden changes.
Kicking the climate systems is likely to have significant consequences.


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dial(redirected from Dial (disambiguation))
Also found in: Dictionary, Thesaurus, Encyclopedia.
A clock face or instrument resembling a clock face.
[L. dies, day]
a circular diagram with black lines radiating outward across a white background from the center, as is used in tests of astigmatism.
dial(dī′ăl) [L. dialis, daily, fr. dies, day]
A graduated circular face, similar to a clock face, on which some measurement is indicated by a pointer that moves as the entity being measured (pressure, temperature, or heat) changes.
astigmatic dial
A circular dial with black lines of uniform width drawn as if they were connecting opposing numbers on the face of a clock. It is used in testing for astigmatism.


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Archived Page
The information on this page is archived and provided for reference purposes only. It was current when it was produced, but may now be out-of-date. Persons having difficulty accessing this information may contact email@example.com for assistance. For reliable, current information on this and other topics, we recommend that you visit the National Eye Institute website index.
Deborah Carper, Ph.D., has been appointed to the position of deputy director of the National Eye Institute (NEI). She has served as the NEI acting deputy director since March 2009. She will be the first female deputy director in the NEI's 40-year history.
During her distinguished 34-year career at NEI, Dr. Carper has published numerous papers on topics including the functional loss of a major beta-crystallin associated with congenital cataract, cloning and sequencing of cDNA for aldose reductase, and translational studies showing that doxycycline and omega-3 long chain polyunsaturated fatty acids reduce ocular neovascularization. Her translational research work has stimulated a proposed clinical treatment trial for retinopathy of prematurity (ROP) in infants, a serious condition leading to a lifetime of limited vision.
In addition, Dr. Carper has been an active leader in promoting women in science by serving as the NEI Women Scientist Advisor on a number of NIH Committees. She has participated on several other NIH committees, most recently as a member and NEI representative to the NIH Basic Behavioral and Social Science Opportunity Network (OppNet) Steering Committee. She has also represented NEI in the broader vision science community by serving on advisory committees for the Association for Vision in Research and Ophthalmology (ARVO).
Dr. Carper has played a pivotal role in NEI's global health portfolio, which will continue to be a critical part of her position as deputy director. She was instrumental in the creation of the Indo-U.S. Joint Working Group and is the NEI representative on the NIH Global Health Research Working Group.
Dr. Carper has been recognized for her research and leadership achievements through many awards, including the Alcon Research Institute Scientific Achievement Award, the Juvenile Diabetes Foundation Intramural Award and the Rohto Cataract Research Award.
Dr. Carper earned a Bachelor's degree and a Ph.D. in zoology from the University of Maryland, College Park. She served as a research technician at the National Heart, Lung and Blood Institute before coming to NEI in 1976. At NEI, she worked as a biologist and principal investigator in the Laboratory of Vision Research and the Laboratory of Mechanisms of Ocular Diseases (LMOD) before serving as chief of the LMOD Section on Molecular Therapeutics. She also coordinated the Research and Education Training Section of the NEI Division of Intramural Research. She has transitioned from the laboratory bench to a scientific management career over the past eight years, serving as special assistant to the director and most recently as acting deputy director, NEI.
In the role of deputy director, Dr. Carper will continue to participate in evaluating, planning, directing and coordinating all of the Institute's activities in support of the NEI mission.


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Only hotels in 07065 zip code are listed below. Search for cheap and discount hotel rates in Rahway, NJ for your upcoming leisure or conference / group travel. We list the best 07065 hotels and motels so you can review the Rahway hotel list below to find the perfect lodging. Hotels in Union county and area code 732 are also listed.
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I can't take all the credit for the backstory. The basic information came from Ships of the Star Fleet Volume 1. The destruction of the Prolaya appears in one sentence on the lead page for the Surya class (basically "The USS Prolaya was destroyed near Beta Aurigae in 2249 by Klingon-allied warships."). I pulled the construction, launch and commission dates from the chart of starships on the following page. Everything else is my own creation.
This was a great learning experience, and I enjoyed the build. I'd do a few things differently the next time I build a vacuform kit, but they no longer scare me. Well . . . . maybe the 41-inch Lunar Models USS Excelsior that's up in the closet does a little, and the Minbari Sharlin Class Cruiser . . . .
1:650 Surya Class (final pics page 5)
Each participant will have their own Work in Progress thread, which will be updated as the contest progresses. Please note that spectators aren't allowed to start new threads, but can reply to existing ones.
- Crafty Commodore
- Posts: 1105
- Joined: Sun Oct 07, 2012 11:06 pm
- Location: Up to my eyebrows in unbuilt models!
- Contact:
Re: 1:650 Surya Class *FINISHED*
Check out the Sci-Fi Model Kit Directory - A searchable resource with kit reviews and information on how to find the kit you're looking for! Visit http://www.sfmkd.com today!
- Erratic Ensign
- Posts: 10
- Joined: Sat Nov 10, 2012 2:10 pm
- Location: Ontario Canada
Re: 1:650 Surya Class (final pics page 5)
Nice work I really enjoyed the back story to her
Live Long and Prosper Technically
Bernard Guignard
Project Manager TreknoGraphx
http://groups.yahoo.com/group/treknogra ... d=89237652
Bernard Guignard
Project Manager TreknoGraphx
http://groups.yahoo.com/group/treknogra ... d=89237652


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BWW Reviews: Creede Reperatory's Presents Fantastic Whimsy Mark Twain's IS HE DEAD?
The Arvada Center is proud to host the Creede Repertory Theatre production of IS HE DEAD? a comedy by Mark Twain playing now through October 28th. Jean-Francois Millet, a young painter of genius, is in love with the beautiful Marie Leroux but in debt to a villainous picture-dealer, Bastien Andre. He forecloses on Millet, threatening debtor's prison unless Marie marries him. Millet realizes the only way he can pay his debts and keep Marie from marrying Andre is to die, as it is only dead painters who achieve fame and fortune. Millet fakes his death and prospers, all the while passing himself off as his own sister, the homely Widow Tillou. Now a rich "widow," he must find a way to get out of a dress, return to life, and marry Marie. The romp is on in this delightful farce as he pursues his passion for painting, his fortune and the woman he loves.
First I have to commend David Ives on his genius adaption of this unknown Mark Twain work that transformed this story into leisurely conversational speak with great ease. This show as a whole was just fantastic and had a great energy throughout with just the right amount of melodrama. I knew this was going to be a good show when I saw each other the actors concentration in the painting scene and their melodramatic reactions. I loved the irony of the dead artist - you cannot become a famous, rich artist until you are dead; but when you are dead, you cannot reap the rewards of being a famous artist. Aside from being a physical comedy, the show was also filled with naughty humor and nothing is funner that a cross dressing disguise. The show truly was all about the timing and the audience absolutely ate it up. At the end of Act I, you wondered where in the world Act II could go and could it get any funnier. When you see 5 doors in the beginning of the act, you knew you were in for a good time and felt like an episode of laugh-in.. Daisy/Millet was facing an identity crisis being trapped as a woman and away from his true love. The kings were over the top funny and the grand reveal at the end of the show was just fabulous. I say this with all sincerity, you do not want to miss the curtain call that will have you on the floor in laughter and then on your feet in applause!
Scenic Design Jon Young and Hana Goff was absolutely wonderful form the run down artists loft to the Parisian penthouse, both sets showed great contrast vibrant with color. The thoughtful lighting by designer Ryan Wentworth further enhanced this gorgeous set. I loved sound designer, Steve Stevens colorful play list for the show (Tom Jones - She's a Lady, Aerosmith - Dude Looks Like a Lady, etc). The costumes by designers Tatyana De Pavloff and Nina Silfverberg were marvelous rich with color. Each costume fit the characters personality to a t. Director Michael S. Pearlman found the best talent for these roles and really pushed them to bring out the funny in each line and his concentration to those many reactions from the entire cast should also be noted and praised.
The Arvada Center hosts the critically acclaimed Creede Repertory Theatre's presentation of IS HE DEAD? adapted by David Ives from an unpublished story by Mark Twain in the intimate Black Box Theater now through October 28th. Performances are Tuesday through Saturday at 7:30 p.m., Wednesday at 1:00 p.m., Saturday and Sunday at 2:00 p.m. For tickets or more information contact the box office by calling 720-898- 7200 or go online to www.arvadacenter.org. Pre-Show talks will be offered for all preview performances, and the following dates closing weekend: October 25, 26, 27, at 7:30 p.m. and Sunday, October 28 at 2:00 p.m. Designed to immerse audiences in the world of the play before the curtain rises, these entertaining talks explore the historical context of the play, essential themes, significance the play holds for Creede Rep, and challenges faced during production. Talks are free of charge, will begin 30 minutes prior to these select shows and last approximately 15 minutes. Audience Talk Backs with the cast will be offered Wednesday, October 17 after 1:00 p.m. show. Is He Dead? will be American Sign Language (ASL) interpreted for the hearing impaired on Friday, October 26 at 7:30 p.m.
Creede Repertory Theatre (CRT) is an award-winning theater company located in the San Juan Mountains of Colorado. The Company presented the world premiere of Is He Dead? as part of its recently completed 2012 summer season. The comedy marks the third collaboration between the Arvada Center and CRT.
Caitlin Wise as Marie and Steven Cole Hughes as Millet
L-R: Anne F. Butler (Madame Bathilde), Steven Cole Hughes (Millet) and Christy Brandt (Madame Caron)
John Arp as Bastien Andre


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The Treasurer of the
State of New Jersey serves as the primary information repository for the
State's business, legal and financial communities. Through the Division
of Revenue, the Treasurer administers a wide variety of public records services
ranging from corporate filing to Uniform Commercial Code filing and debtor
searching. Online access to public information is provided through the Business
Gateway Registry Services page.
at 33 West State Street in Trenton, the Business Services Office (formerly
Commercial Recording) provides a number of different service options for
its clients. These include regular mail-in service, over-the-counter expedited
service with 8.5-business hour turnaround, and online
services. Selected same business day service offerings are available
and include walk-in registration for both Business Tax Registration and
Certificate of Incorporation. Telephone service for corporate name availability
and status reporting is also provided.
Additional information
on various public records services is available through the Business
Gateway or by consulting any of the pages highlighted below:
Filing **NEW SAME DAY SERVICE AVAILABLE**


text: The Model A - Single is a high-low gas pressure switch that monitors pressure and cuts off the electrical control circuit when pressure rises above or drops below the desired set point. The high and low gas pressure settings are adjustable. All models are available in reset or recycle type.


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September 14, 2012
Raymond Hill, FMedSCi
Imperial College London
View Article as PDF
A new report from PhRMA (medicines in development for mental illnesses) highlights the statistic that 1 in 4 American adults suffer from some form of mental illness and that this costs the US economy more than $317 billion annually. It also points out that 200 medicines are now in clinical development for mental health indications. Sadly most of these medicines are not new but are variations or re-formulations of medicines we already use and the number of really new approaches to mental illness is very small.
A recent article in Nature1 states that 13% of the global burden of disease is attributable to mental, neurological and substance abuse disorders, surpassing both cardiovascular disease and cancer. To make matters worse, at a time when the need for drugs to treat mental health problems has never been greater, many of the larger companies in the pharmaceutical industry have been making dramatic cuts in their worldwide research investment in this area2. Part of the reason is the difficulty of developing such drugs. Companies have decided that psychiatric diseases are too complex to allow profitable drug development3. The required clinical trials depend on soft behavioral endpoints in the main and there are no established biochemical surrogate markers to inform such studies4.
The time taken to develop CNS (Central Nervous System) drugs is longer than for other therapeutic areas (phase II and III take an average of 8.1 years and some drugs have taken as long as 18 years to develop) and the rate of success is lower (only 8.2% of CNS clinical drug candidates become available for use in patients).
The drugs that we currently use did not arise from an understanding of the disease process so they do not necessarily point to where we should look next for new treatments.
These partially effective drugs that we use to treat disorders such as depression and schizophrenia were derived from inspired empirical research in the 1950s5. This theme of research lasted nearly 40 years. Although it involved much virtuoso medicinal chemistry, it did not help us understand why patients suffer from depression and what really happens in their brains to cause the disorder. There is a similar situation with the treatment of schizophrenia.
The key drugs for treating a number of severe and hitherto untreatable neuropsychiatric conditions were introduced by empirical methods. They have been of enormous benefit to more than a generation of patients but have left drug discovery scientists with a dilemma as to how they produce improved treatments without a clear understanding of disease pathophysiology. The best clues we have at present have come from the actions of drugs rather than from disease mechanisms. For example, blocking the effects of glutamate at the cation channel coupled receptor sensitive to N-methyl-D-aspartate (called the NMDA receptor for short) with agents such as phencyclidine or ketamine produces symptoms that resemble those seen in patients with schizophrenia. Agents that can modulate the actions of glutamate in the brain by acting at what are called metabotropic glutamate receptors (mGluRs) are currently being evaluated as potential treatments for schizophrenia6.
Another example is the realization that the monoamines thought to be implicated in depression have their secretion controlled by a variety of peptide neurotransmitters. Also, blockers of some neuropeptide receptors, such as the NK1 receptor at which substance P has its actions in the brain, have animal pharmacology that resembles that of known antidepressant drugs such as the SSRIs. This has led to clinical trials of NK1 antagonists as treatments for depression7. In both the examples given, early clinical studies looked promising. But, it has so far not been possible to get robust phase III clinical data that would support registering one of these drugs as an approved treatment.
It is therefore necessary to go back to basics and to try to understand the anatomical and biochemical basis of the diseases that we need to treat. Studies on post-mortem brain samples taken from patients dying with neuropsychiatric disease have been conducted for many years but have not generally been helpful. Biochemical changes found after death may not necessarily reflect the situation in life. Even when anatomical changes are examined, there is a problem in obtaining age-matched control samples that allow differentiation of age and disease related changes. Also, as little data is available on subjects who have not been treated with drugs, there is always the possibility that the changes seen are drug rather than disease-related.
However, we are now in a new research era based on advanced imaging techniques8 and genetic studies that hopefully will lead to new and better treatments. As a result the clock has been reset . Although much of the pre-existing research on antipsychotic and antidepressant drugs will not be helpful in this endeavor, we may at last be on the way to understanding the causation of these important diseases.
The use of magnetic resonance imaging (MRI) has allowed patients to serve as their own controls and in-life anatomical measurements can now be made at the time of diagnosis and then followed over many years. For example, a study on twins from families with a high risk of either schizophrenia or bipolar disease showed that decreased white matter volume and thinning of particular areas of the cerebral cortex was associated with the presence of genetic risk factors9.
It has also recently been shown that when individuals with a high genetic risk of schizophrenia use cannabis ,they are likely to show a loss of volume in a brain area called the thalamus, which may help explain why some but not all cannabis users are at risk of developing the symptoms of schizophrenia10.
The use of functional MRI (fMRI) allows relative activity of brain areas to be studied and parallel NMR (Nuclear Magnetic Resonance) spectroscopy allows some brain biochemistry parameters to be measured in-life. MRI techniques are non-invasive and can be applied to healthy control subjects with minimal ethical concerns, such that it is also possible to obtain control data from non-afflicted family members of the patients being studied.
The use of positron emission spectroscopy (PET) is generally restricted to patients as this technique involves administration of drugs or chemical probes labelled with short-lived radioactive isotopes. PET makes it possible to get a window on what is happening to specific populations of receptors and to transmitter systems in designated patients. Such studies have confirmed that there are abnormalities in the dopamine neurotransmitter systems in the brains of patients with schizophrenia but that these defects appear to be mainly presynaptic, affecting dopamine synthesis and release processes which are unaffected by current D2 receptor blocking treatments11. It is also clear that genetic association and copy number studies point to glutamate system hypofunction in schizophrenia and this is driving research, especially in the area of new animal models that can be used in drug discovery12.
However, the genetic picture remains complex. We know that although some families have a genetic makeup that gives a high risk of schizophrenia or bipolar disease, there are also sporadic cases where there is no clear genetic association. It is likely that there is a genetic factor in at least 60% of schizophrenics but environmental risk factors also play an important part13.
At present up to 1000 genes have been suggested to be involved in the aetiology of schizophrenia and this clearly does not point to an easily addressable drug discovery target! Much re-investigation of the genetics of schizophrenia is in progress using the most up-to-date techniques which allow sequencing of large regions of the genome. Hopefully new knowledge will soon emerge to help us understand what is needed to allow discovery of a new generation of drugs14. It has also been claimed that for the first time it is possible to find a biological signature for schizophrenia in serum which should assist in the early diagnosis of the disease15.
The problem remains as to where the research to discover new drugs will be conducted. In some cases when companies announced that their internal research efforts were to be terminated they revealed that they have put alternative plans in place. For example, Astra-Zeneca has retained a skeleton group to work with researchers outside the company and to license promising therapeutics from other companies and Novartis has substituted a genetics research group for the traditional CNS drug discovery effort that is being terminated. There is undoubtedly an expectation that the gap left by the big companies pulling out will be filled by a mixture of research done by academic groups and by the small biotech companies.
Although much creative early stage research is going on in this challenging arena, it is unlikely that anyone but the large pharmaceutical companies has deep enough pockets to perform the late-stage clinical trials needed to show that new therapies are effective.
Given the low rate of success in the recent past and the current risk- averse behavior of the large pharmaceutical companies, there is a possibility that exciting new agents taken to the point of first study in human subjects by academic groups or small companies will then struggle to find funding for late stage clinical trials. Although there is a certain amount of government and charity grant money available on a competitive basis to supplement venture capital funding of early stage clinical testing there is no alternative funding for expensive late-stage studies. Until this issue is resolved then the future of neuropsychiatry drug discovery and development at best remains uncertain.
Further reading
HM Ibrahim and CA Taminga (2011) Schizophrenia: treatment targets beyond monoamine systems Ann Rev Pharmacol Toxicol 51: 189 – 209.
PM Matthews (2013) Clinical imaging in drug development in RG Hill and HP Rang (Eds) Drug Discovery and Development (2nd Edition) Churchill Livingston Elsevier pp 259 – 274.
RA Maxwell and SB Eckhardt (1990) Drug discovery: a casebook and analysis Human Press, Clifton NJ pp437
J Pratt C Winchester N Dawson and B Morris (2012) Advancing schizophrenia drug discovery: optimizing rodent models to bridge the translation gap. Nature Reviews Drug Discovery 11: 560 - 579
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Here we have a stunning example of the Triumph Thruxton 1200R, Finished in red, An amazing looking example of this rare retro machine, The red bodywork is complemented with gold ohlins forks and shocks for the ultimate in road holding. and with Bar end mirrors, a race seat pod and Brembo callipers, this machine means business. With only 4399 miles, this bike is ready to ride away today, Supplied by ourselves with a fresh oil and filter service, 37 point comprehensive health check and fully valeted, you have complete confidence when buying from CMC
0% Finance available on clothing, accessories and servicing.
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The best way to get an accurate finance example is to call us. It only takes five minutes and there's no obligation to buy.
Finance is subject to status. Terms and conditions apply. Finance example correct at time of writing.
Duration of agreement 37 months with a £1000.00 deposit
Excess mileage charges: 6p up to 4999 miles and 12p 5000+.
Duration of agreement 48 months with a £939.90 deposit (minimum deposit £99)
Duration of agreement 36 months with a £939.90 deposit (minimum deposit £99)
Duration of agreement 24 months with a £939.90 deposit (minimum deposit £99)
CMC Chesterfield Ltd is a credit broker and not a lender.
Credit is subject to status and is only available to UK residents aged 18 and over.
This finance offer is Hire Purchase and is only available through Black Horse Ltd, St William House, Tresillian Terrace, Cardiff, CF10 5BH.
CMC Motorcycles is a trading style of CMC Chesterfield Ltd
CMC Motorcycles can introduce you to Black Horse Ltd and a limited number of other lenders to provide funding. We may receive commission or other benefits for introducing you to such lenders.
PCP End Of Agreement Options
1. Return the motorcycle and not pay the final repayment. If the motorcycle is in good condition and has not exceeded the agreed maximum mileage you will have nothing further to pay. Further information of what is considered good condition and be found at blackhorse.co.uk/bikeconditionguide. If the motorcycle has exceeded the agreed maximum mileage the charge for excess mileage will apply.
2. Pay the final repayment to own the motorcycle, or
3. Part exchange the motorcycle subject to settlement of the financial agreement. New finance agreements subject to status.
It's easy to spread the cost of your new (or used) bike with us.
Simply call us and we will give you a quote over the phone to suit your needs, or pop in to one of our stores and speak to one of our staff (they are really helpful!).
There's no pressure tactics and we can even help if you have a bad credit history.
Once you are happy with the finance plan, all we need is a few pieces of indentification (our staff will let you know what they need) and a deposit - then the bike is yours to ride away! Just call us or pop in to get started!
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Pop in and see this Triumph Thruxton 1200 R in the flesh. If you need a finance quote or want more details, just ask one of our sales team for details (You might even be able to get a cuppa out of them!).CMC Manchester
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text:
How do I know if I'm a worrier? Many people's digestive systems
are an indi- cation of their worry quotient, either in the form of a nervous
stomach, heartburn,
or constipation or diarrhea before or after a stressful event. Some people get
sweaty, clammy, unusually offensive perspiration, or their faces flush. Others
suffer from chronic stiffness, tightness, or pain of their neck and or are
unable to fall asleep at night or wake periodically during the night. If you
get any of these symptoms when you're under stress, you can probably benefit
from this article.
Why do we worry? l) In utero fears- Many of us are deeply
frightened even before birth. We may pick up the fears of our mothers in utero-
perhaps her fears that she'll miscarry, that there won't be enough money to
provide for a baby, that her husband might leave her, or that she won't be
strong enough to care for a child. One of our patients told us the dreadful
story of how her father pushed her mother down a flight of stairs during her
late pregnancy in hopes of killing her child. Can you imagine the terrifying
effect this could have on that little fetus struggling for life inside its
mother? 2) Childhood losses or traumas- Life-long nervousness often stems from
an early divorce, abandonment, physical or sexual abuse, or other circumstances
which teach us in our tender years that the world is not a safe place. Some of
us go through our entire lives in survival mode in a constant state of fear.
3) Parental conditioning- Others of us, even though we have secure, stable
childhood environments, are exposed to parents who are overprotective worriers.
They teach us that there are dangers lurking behind every corner, that people
may cheat and take advantage of us, and that we need to sleep with one eye
open, so to speak. We may also be programmed for perfection so that we believe
we need to worry about every little detail or we may (heaven forbid!) actually
make a mistake. 4) Adult worry mentality- Later events in our lives may
reinforce the tendency to nervousness and overcon- cern about everything. If we
experience what we perceive as failures, we may be- come stuck in an endless
loop of fear and blame and feel that worrying about everything is better than
doing nothing!
Worry myths: If I don't worry about it, who will? Stop for
a minute and think about this one. Is it possible that there is another
approach? An alternative to taking it all on yourself? What if you could really
trust someone else to do it right? And what if you discovered that they could
even do it better than you? There's something wrong with me if I'm
not worried all the time. Aren't I supposed to worry about things?
Please understand that this is a faulty premise, a misunderstanding of the
obsessive part of you. It's perfectly okay to be calm and relaxed, even before
a major performance or decision. It's great to go to a movie the night before
an exam. It's fine to make fun of the those moments which seem so terribly
serious. In fact, you'll find that the less you worry about your life, the
more it can find its natural flow, which will turn out far better than you
could have ever consciously imagined. Why spoil your life with your own limited
expectations? What will I do with my time if I don't spend it worrying?
How about a soothing hot tub while listening to the most wonderful music yo can
think of? Curling up by a fire with your favorite book? Snuggling up with a
lover and treating yourself to hugs and kisses? Enjoying the raindrops in your
hair as you stroll along the beach? Sitting in a chair or on your meditation
pillow, lighting a candle and stick of incense, and sinking into a deep