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Semi-Automatic Espresso Machines
Be your own barista! Semi-automatic espresso machines offer just the right amount of control over how your espresso is made at home. While they may look different, the basic functionality of a semi-automatic espresso machine includes a boiler, a portafilter and a switch or lever to perform the extraction. You'll still grind and tamp your espresso (or insert an espresso pod), start the extraction and then steam or froth your milk as necessary. Semi-automatic espresso machines fall into two different types:
- Manual Control: On these semi-automatic espresso machines, the shot is initiated and you stop it once you decide the extraction is complete, usually in 20-30 seconds. This offers real-time control over the length of your extractions
- Programmable Doses: These semi-automatic espresso machines allow you to program the extraction to stop after a specific amount of time.
Learn More about Semi-Automatic Espresso Machines
Crossland Coffee CC1 Version 1.5 Espresso Machine
Regular Price: $749.00
Our Price: $699.00Move over Rancilio Silvia, the Crossland Coffee CC1 Version 1.5 espresso machine is here. And it's got credentials in spades: an innovative PID built right into the interface, thermoblock-enhanced steam and even more intuitive controls for perfecting your shot and keeping it consistently delicious. Learn More
Saeco Aroma Espresso Machine
Regular Price: $279.20
Our Price: $199.00The Saeco Aroma is a compact and durable espresso machine that makes brewing your favorite espresso, cappuccino or latte beverage a snap. With the Aroma Espresso Machine, you have the option to use already ground espresso or E.S.E compatible pods using the included special adapter. The Aroma's pressurized portafilter makes it one of the best performing home espresso machines we have tested. Place this cool and compact espresso maker just about anywhere in your kitchen or coffee space. Learn More
Saeco Poemia Espresso Machine
Regular Price: $179.00
Our Price: $174.95For those of you who want to be your own home barista but feel like you don't have the experience, the Saeco Poemia is your new best friend. A great learning machine, it is easy to use and forgiving of many rookie mistakes. With a pressurized portafilter, there is no need to perfectly tamp your espresso in order to pull a great shot. The panarello wand on makes milk frothing a breeze! You'll be making lattes for your friends in no time! The design is similar to higher end Saeco machines, stylish and affordable. Learn More
Breville Infuser Espresso Machine
Regular Price: $799.99
Our Price: $499.99For espresso lovers who want a machine that offers stability and control without breaking the bank, Breville created the Breville Infuser. It provides steady low-pressure pre-infusion that gives espresso shots a full flavor and aroma in every sip. The Infuser incorporates built in PID temperature control. Learn More
Breville Barista Express Espresso Machine
Regular Price: $999.99
Our Price: $599.99Ready to unleash your inner barista? The Breville Barista Express is built to set you up for success. Featuring an integrated conical burr grinder, this machine cuts down the time between grinding and extracting leaving you more time to enjoy the exquisite tasting shots. Professional-grade features include a 15 bar pump, PID regulated temperature control, and swivel mounted steam wand. With its high quality die-cast casing and streamlined design, this machine means business, barista business that is! Skip the line and make delicious coffee drinks at home morning, noon and night. Learn More
Saeco Via Venezia Espresso Machine$299.00The Saeco Via Venezia is beautifully constructed with a stainless steel casing. It incorporates some of Saeco's most time-tested features. The Via Venezia produces creamy, robust espresso each and every time. You'll also find the panarello has a frothing tip for perfect form, a large water tank, a powerful pump rated at 15 BAR of pressure and a safe, and a rapid recovery boiler that keeps the hot water coming. Learn More
DeLonghi BAR32 Retro Pump-Driven Espresso Maker
Regular Price: $210.00
Our Price: $99.95The BAR32 Retro Pump-Driven Espresso Maker by DeLonghi is a great option for first-time espresso brewers who need reliability and ease-of-use, but want an affordable, entry-level machine. With pod convenience (use either standard ESE pods or your own ground coffee), a frothing wand for fluffy foam, a pressurized portafilter and dual thermostats for water and steam, we're sure you'll love your foray into espresso making on the DeLonghi BAR32. Learn More
DeLonghi ECO310BK Espresso Machine
Regular Price: $249.95
Our Price: $199.95DeLonghi ECO310BK Espresso Machine's 15 bar pump driven espresso machine combines modern lines and retro accents. Using either E.S.E. pods or freshly ground beans, you can quickly make any espresso-based drink. Learn More
DeLonghi EC155 Espresso Machine$99.95Easy to use and extremely affordable, the DeLonghi EC155 Espresso Machine is an ideal machine for those looking to make the switch from instant or drip coffee to a much stronger brew. The EC155 is pump-driven and sports DeLonghi's exclusive Cappuccino Frothing Wand, which delivers rich, delicious crema each time you use it. At such a reasonable price, it's hard to pass up on this marvel of a machine. Learn More
Capresso Cafe Espresso Machine
Regular Price: $159.99
Our Price: $152.67It's a must have for those who need to save some serious space: the Cafe Espresso Machine from Capresso. This mini-sized marvel features a thermoblock heating functionality to quickly switch between steaming and brewing. As for the steam wand, Capresso is all about giving you options. The Cafe Espresso Machine has an easily adaptable steam wand to infuse the right amount of air and steam for a nice microfoam, or you can remove it and use a standard steam wand. A pretty rare feature at this price point, indeed. Learn More


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Onguma Tree Top
Situated just outside the eastern side of Etosha National Park on the Onguma Reserve, the fairly new Onguma Tree Top Camp is in an ideal location for visiting Etosha National Park. Raised on stilts above the bush among the trees that give it its name, Onguma Tree Tops has a real bush feel to it.
Our view of Onguma Tree Top
The peace and privacy of Onguma Tree Top Camp make it a good spot for a group of friends or a family who want a more private place to stay. It's convenient location, excellent service and food and wonderful bush feel should attract those with a sense of adventure who want to get a little closer to the wilderness.
Onguma Tree Top: Traveller ratings
Onguma Tree Top Camp (viewed here from its waterhole)...

subset: commoncrawl


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On Tuesday at lunchtime, students navigated pizza boxes and a packed auditorium for the semester's first Town Hall meeting. Dean Glenn Hubbard addressed the school-wide audience about the near and long-term economic impact of the current Wall Street crisis. He also addressed the job market, a source of great concern for many students, saying:
A question that may be on your mind is "Does financial services need to shrink?" There will be job losses and exits, not only with the firms that have exited but probably more. But I have considerably more optimism for the medium term in financial services, and there are three simple reasons for that:
- The global phenomenon of an aging society puts pressure on the demand for a whole variety of financial products and services. This isn't as well developed as it should be in the U.S. or the U.K., let alone in many emerging economies, and the number of return income vehicles, insurance products and so on will increase.
- Many of the big emerging economies are improving their domestic demand, which will generate a huge demand for financial services as they exit from the state provision of services to the market.
- The overwhelming forces of globalization and the demands for international finance. Anyone who says that the financial sector is going to shrink out of business has not been through these cycles before.
Dean Hubbard urged students to remain flexible and keep perspective.
"We are behind you," he said. "Ask yourself, 'What are the right jobs for me on my career ladder?'"
Photo credit: Catherine New


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That would help some, but the barrel is a straight taper.
That would help some, but the barrel is a straight taper.
Whatever happened on your 45-70 project? I have one that is nearly complete, needs extractor work. I picked up the barrel from Sarco (Gibbs old stock) and installed it on a No1MkIII receiver. Picked up the mag for it a while back for about $70, oh well. I did all the receiver opening with a dremmel, and the round feeds smoothly w/o the extractor installed on the bolt head. With the extractor, it grips the rim too hard and causes the round to twist just enough to impede feeding. I was expecting to need to modify the extractor, just hadn't got down to figuring it out. Have you done that step yet? Advice/pointers would be appreciated.
I used a bubba'd SMLE stock, and also had to open up the barrel channel to accommodate it. I am missing a couple of small parts that I need to track down, lost track of them over time, but nearly ready to go.
It's still parked. I haven't cut the extractor groove in the barrel yet.
How thick are the rims on your cases? There's a lot of variation in specs for different brass. If you have thick rims, it might be worth just going to a different brand of brass.
The SMLE extractor has a very long stroke; up in Canada people have done 7mm Mauser conversions and claim the unmodified extractor works find with the rimless case.
The extractor is *supposed* to be able to push the case to the left. That preloads the case against the left side of the chamber for consistency, sort of like a the ejector pin on an AR or a Savage. And it keeps the case pushed to the left side of the receiver, so it will slide across the bolt face a bit as the bolt strokes back, so it can hit the ejector screw.
The left sidewall is actually scooped out a bit to let the case slide over; that's one reason the bolt feels loosey-goosey.
How's your headspace? You might be able to take a little off the bolt head face to get more extractor bite.
I never did get any feedback on the varying rim thicknesses of .45-70 brass on any of the boards where I asked, and the only local place that had used brass went out of business.
I'm tempted to set my rifle up tight on an .062" rim, and face off the front of any thick rims on the lathe to .062". Just reaching in with a parting tool should do it. You can't take of off the back of the case without making the primer pocket shallower.
In my case, I'll probably just "adjust" forty or sixty cases, which will probably last me the rest of my life... I'm not worried if it won't handle all commercial ammunition. Though, really, the change in headspace doesn't seem to be an issue with .45-70 guns in general, and if there's any platform that has proven it can handle excessive headspace, it's the SMLE!
No problem with headspace. The only issue is that, when stripping the round from the magazine, the extractor has to flex much farther out than for the .303 round, and it grips the rim very tightly, and the tension is much stronger, actually causing the round to pull up and to the right slightly, keeping it from feeding the front of the round in. Without the extractor installed, the round feeds smooth as silk. I have the extractor cut in the installed barrel, and the round extracts properly if I guide it in and close the bolt completely.
A ha! Now I understand your question.
The Gibbs I played with did something similar, though I didn't have it long enough to figure out what was causing it.
As a plan of attack, I would take a minimum amount off the extractor, then try a lighter spring. You can probably go a lot lighter than stock; the larger cartridge doesn't need to move as far over to reach the ejector pin, and you don't have to worry about the extractor still working reliably with crusted full of filth.
Extraction shouldn't be an issue, I'm just paranoid about breaking extractors for some reason.


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|Alex Smith
Courtesy: CMU Athletic Communications
Release: 09/10/2012
2013: [Game-by-Game Statistics] Played in 11 games ... totaled eight tackles ... had one sack for a loss of three yards in season opener at Michigan (8/31) ... made three tackles (2 solos) in road win over Miami (Ohio) (10/5) ... tied his season high with three tackles, including one for a loss, in win at Ohio (10/12).
2012: Played in four games, starting the first three of the season at defensive end ... recorded three tackles and a half sack in season opening win over Southeast Missouri State (8/30) ... started against Michigan State (9/8) ... had one tackle in win at Iowa (9/22) ... played versus Northern Illiinois (9/29) but missed the remainder of the season with an injury.
2011: [Game-by-Game Statistics] Played in nine games, starting twice at linebacker ... made first start of the season at Western Michigan, recording a career-high seven tackles (9/17) ... recorded two tackles, including one for a loss, and a quarterback hurry at Michigan State (9/24) ... recorded four tackles against Eastern Michigan (10/15).
2010: [Game-by-Game Statistics] Starter first three games at linebacker ... recorded a pair of tackles in first career start at linebacker against Hampton (9/2) ... set a season high with five tackles and forced first career fumble at Eastern Michigan (9/18).
2009: [Game-by-Game Statistics] Played in 14 games, primarily on special teams, to earn first varsity letter … made a season-high three tackles against both Alcorn State (9/19) and Eastern Michigan (10/10) ... recorded first career interception against Toledo (11/11).
High School: Two-year starter … helped lead team to a 9-3 record and Class 8A state quarterfinals appearance in 2008 … named to the Chicago Sun-Times Top 30 … earned all-area and all-conference honors in 2007 and 2008 … credited with 101 tackles, including 18 tackles for loss and eight sacks, as a senior … earned one varsity letter in track and field.


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This is an outstanding wireless security system in an ultra-compact panel. You can customize the panel with different colored skins, from gun metal to baby blue. Bottom line – small size, but big performance!
Visonic Compact Wireless Home Security System. Self-Monitoring home security system with no monthly monitoring fee required. Calls your cell phone or 4 Private telephone numbers of choose.
The Home Security Visonic Powermax Design Express is unique among alarm systems and is EXCLUSIVE to Home Security Store, meaning you won't find it anywhere else. Meant to protect against burglary, fire, and even tampering, the Design Express is not only sleek and stylish so as to fit with any home decor, but it features a powerful all-in-one, self-contained panel that simultaneously functions as controller, receiver, sounder and keypad. This control panel is equipped to monitor and collect data from an unprecedented 28 wireless zones, as well as 1 additional hardwired zone. That means that no matter how large your space is, you can integrate various motion, flood & smoke detectors, window & door contacts, sirens, additional keypads, and more!
The Home Security Powermax Design Express Kit has different functions depending on whether it is in an armed or disarmed state. In its armed state, the system will initiate an alarm when disturbance is detected in any of the armed zones, i.e. the PIR detector sensing unauthorized motion in its designated zone. On the other hand, while in its disarmed state the system will provide you with visual status information, and will trigger an alarm if smoke is detected (if you integrate a smoke sensor) or when a disturbance occurs within a 24-hour zone.
Changeable Skins
You can't get more stylish than the Home Security Powermax Design Express Kit. Featuring 8 changeable skins in different vibrant colors including brown, baby blue, canary, ivory, slate, gun metal, silver and evergreen, you can match your alarm kit to virtually any style and color decor within your home. Sticking and unsticking your color skin is easy and will leave no unsightly residue behind.
Customizable Color Skins
Control Panel Features
PSTN (Public Switch Telephone Network)
The Home Security Powermax Design Express is unique among alarm systems of its kind as it features a sophisticated in-built PSTN alert feature. Let's face it, you can't stay at home all day. So while you are away or simply at work during the day, this system will keep you notified of any disturbances occurring at your residence by simply calling you (through a landline connection) or another private telephone number with a unique siren signal signifying either a FIRE, a BURGLAR or another emergency. Acknowledgment of the message is required and simple to do, but in case you miss the call, the system will continue to reach you until you are properly alerted. The PSTN feature is useful for anyone wanting to control their alarm system remotely also. Simply use your private phone to dial into your Express Kit and you can both arm or disarm your system using a series of executable commands right from your keypad.
Looking After People Left at Home
If you have elderly or disabled loved ones who are frequently left at home, the Powermax Design Express is designed specifically to cater to precisely this situation. The Design Express Kit can be programmed to perform contrary to the system's usual behavior and monitor when motion is NOT detected. Indeed, it is only natural that even the most immobile of elderly and disabled persons will move at least occasionally, whether to turn over in their sleep, or to simply grab something from the kitchen. You can, however, set a "lack of motion" time limit that will trigger an alarm if motion hasn't been detected for a long period of time. The countdown will restart if motion is detected at any moment within the time frame.
Optional GSM Module
Additionally, the Home Security Powermax Design Express Kit can be expanded to include a GSM module (not included). A GSM module is useful both because as a cellular-based device, it can provide backup protection in case your PSTN connection is down, so you'll never miss a single crucial alert in case of a burglary. More impressively, however, a GSM module will allow you to both send and receive SMS (text) messages to and from your private cellular phone. The Express Kit can be programmed to alert a maximum of 4 pre-selected telephone numbers to TEXT in case of an emergency, while arming, disarming and other remote commands to your system is as simple as sending a 1 to 3 word SMS message instantly.
PLEASE NOTE: While the PLINK2 Module available in the accessories tab is also compatible with this unit, you may not use a GSM module with the PLINK2 accessory simultaneously.
(2) Visonic Miniature Wireless Contact - MCT-320
The MCT-320 is meant primarily for protecting doors and windows. The MCT-320 uses a built-in magnet that works in conjunction with a magnetic contact to detect precisely when a door or window are being opened/closed. The MCT-320 is ideal for both your home or business, while its very small size is convenient both because it is virtually invisible and easy to install.
The MCT-320 also features a unique anti-collision algorithm that prevents what is known as "signal jamming" by the simultaneous transmission of multiple devices. The MCT-320 is able to transmit periodic "supervision signals" to confirm that your system is connected at all times.
(1) Visonic Wireless Pet Immune Motion PIR Detector 85lbs - K9-85MCW
The Next K9-85 MCW is a PowerCode wireless digital PIR detector designed to enable homeowners to secure their homes while allowing their pets to move freely anywhere in the house. Employing Visonic's patented "Target Specific Imaging" optical system (TSI) and unique pet identification software algorithm, the Next K9-85 has an unprecedented capacity to reliably distinguish between human bodies and pets weighing up to 38 kg (85lb).
(1) Visonic 6-Button Miniature Wireless Two Way Keyfob - MCT-237
The MCT-237 is a 6-button miniature wireless 2-way keyfob with an icon-based LCD display designed for arming and disarming the security system, as well as for emergency signaling, query for status and home automation applications. It provides instant visual and auditory feedback regarding the system status and whether a command has been successfully executed, so that users can always be certain that the system has carried out their command.
Unique to the PowerMaxPro and PowerMaxComplete security and control systems, the MCT-237 offers the ultimate in ease and performance by integrating an LCD screen in a 2-way keyfob.
Frequently Asked Questions
In the event of a power failure, how long will the back-up battery power the Design Express?
The battery can power the Design Express for approx. 24 hours.
In the event that the alarm is triggered, how long will the alarm sound before the Design Express resets itself?
The alarm will sound for approx. 4-5 minutes before resetting.
Is the Design Express compatible with a VOIP (voice over internet protocol) phone, such as Ooma?
Unfortunately our alarm systems do not work with VOIP phone.
Is the Design Express alarm system X10 compatible?
Unfortunately the Design Express system is not X10 compatible. For an X10 compatible alarm please see the PPRO211GSM or PPRO211 systems.
Can the Design Express be used without monitoring?
Yes, the Design Express can be used merely as a noise maker if you'd prefer.
Note: ForSIA CP-01 compliance, when using MCT-234 an external siren must also be used.
Wireless Motion Detector - NEXT K9-85 MCW
Miniature Wireless Contact - MCT-320
6-Button Keyfob - MCT-237
Can't find what you're looking for or need help? Please call us: 1-(888)-501-7870


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Chronic pain after breast cancer surgery occurs in approximately 50% of patients.1,2 The severity is variable, but sensory disturbances including paresthesias and phantom breast phenomena occur in approximately 47%.3 Potentially, this problem may increase with higher incidence of detected breast cancer and improved survival.4,5 Reasons for chronic discomfort after surgery are varied and complex, but nerve damage associated with axillary lymph node dissection is the most commonly reported cause and is associated with a doubling in prevalence compared with cases without this procedure.1 Interactions among treatment modalities such as type of breast surgery, axillary procedures, adjuvant chemotherapy, and radiation therapy add to the difficulty involved in the overall evaluation.1
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GoAnywhere Gateway acts as an enhanced reverse proxy that provides an additional layer of network defense. It allows your trading partners to connect to GoAnywhere Services without having to open incoming ports into your private network or store sensitive information in the DMZ. GoAnywhere Gateway is certified VMware Ready. GoAnywhere Gateway serves as a transparent interface between external clients and GoAnywhere Services without exposing sensitive files and the private network. This is an essential solution for meeting strict security policies and complying with state privacy laws, HIPAA, PCI DSS, SOX, and GLBA.
GoAnywhere Services allows trading partners and employees to securely connect to your organization and easily download or upload files. Popular file transfer and encryption standards are supported without the need for proprietary client software. It supports FTP, SFTP, FTPS, HTTP, and HTTPS, provides a pure Web client for simple file transfers, includes event triggers based on user-defined conditions, generates detailed audit logs and alert messages, provides trading partners with account wizards and permission controls, features an intuitive browser-based interface for remote administration and monitoring, and requires no programming or special skills.
A framework for distributed industrial automation and control.
A Grails 2 tag library that provides useful social media tags to include in Web pages.


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Veliparib and Carboplatin in Treating Women With HER2-Negative Metastatic Breast Cancer
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- No Study Results Posted
- Disclaimer
- How to Read a Study Record
This phase I clinical trial is studying the side effects and best dose of veliparib when given with carboplatin and to see how well they work in treating women with human epidermal growth factor 2 (HER2)-negative metastatic breast cancer. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Veliparib may help carboplatin work better by making tumor cells more sensitive to the drug.
BRCA1 Mutation Carrier
BRCA2 Mutation Carrier
Estrogen Receptor-negative Breast Cancer
Estrogen Receptor-positive Breast Cancer
HER2-negative Breast Cancer
Male Breast Cancer
Progesterone Receptor-negative Breast Cancer
Progesterone Receptor-positive Breast Cancer
Stage IIIB Breast Cancer
Stage IIIC Breast Cancer
Stage IV Breast Cancer
Triple-negative Breast Cancer
Drug: veliparib
Other: fluorine F 18 fluorothymidine
Other: diagnostic laboratory biomarker analysis
Other: pharmacological study
Drug: carboplatin
Phase 1
|Study Type:
|Study Design:
|Endpoint Classification: Safety Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase 1 Dose-escalation Study of ABT-888 (Veliparib) in Combination With Carboplatin in HER2 Negative Metastatic Breast Cancer
- Number and severity of toxicity incidents to measure the safety and tolerability of this treatment combination for the treatment of HER2 negative metastatic breast cancer [ Time Frame: Up to 12 weeks post-treatment ] [ Designated as safety issue: Yes ]Non-hematologic toxicities will be evaluated via the ordinal Common Terminology Criteria for Adverse Events (CTCAE) version 4.0 standard toxicity grading. Hematologic toxicity measures of thrombocytopenia, neutropenia and leukopenia will be assessed using continuous variables as the outcome measures (primarily nadir and percent change from baseline values) as well as categorization via CTCAE standard toxicity grading. Frequency distributions and other descriptive measures will form the basis of the analysis of these variables.
- Clinical response (complete and partial response as well as stable and progressive disease) [ Time Frame: Up to 12 weeks post-treatment ] [ Designated as safety issue: No ]Responses will be summarized by simple descriptive summary statistics delineating complete and partial responses as well as stable and progressive disease. Response and progression will be evaluated in this study using the new international criteria proposed by the revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline (version 1.1).
|Estimated Enrollment:
|Study Start Date:
|November 2010
|Estimated Primary Completion Date:
|January 2015 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Treatment (veliparib, F 18 fluorothymidine, carboplatin)
Patients receive carboplatin IV over 1 hour on day 1 and veliparib PO twice daily on days 1-7 or 1-14. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may undergo fluorothymidine PET scan and peripheral blood cell and tumor tissue collection periodically for correlative studies.
Drug: veliparib
Given PO
Other Name: ABT-888Other: fluorine F 18 fluorothymidine
Undergo fluorothymidine PET scan
Other Names:Other: diagnostic laboratory biomarker analysis
Correlative studiesOther: pharmacological study
Correlative studies
Other Name: pharmacological studiesDrug: carboplatin
Given IV
Other Names:
Detailed Description:
I. To determine the recommended phase II dose of veliparib along with carboplatin on a 14-day and 21-day schedule in patients with Her2 negative metastatic breast cancer that are estrogen receptor (ER)/progesterone receptor(PR) negative or ER and/or PR positive with defects in Fanconi Anemia (FA) pathway repair genes.
II. To determine the safety and tolerability of combining veliparib on a 14-day and 21-day schedule with carboplatin in this patient population.
III. To determine the preliminary efficacy of this combination in this patient population.
I. To determine the pharmacodynamic endpoints of poly(ADP-ribose) polymerase (PARP) inhibition in the tumor by using, A) 3'-[F-18]Fluoro-3'-deoxythymidine Positron Emission Tomography (FLT-PET) of the target lesions, B) circulating tumor cells to detect the induction of the histone variant gammaH2AX, and C) peripheral blood mononuclear cells to assess poly ADP-Ribose (PAR) levels.
II. To determine biomarkers in the primary tumor that may predict antitumor responses to PARP inhibition such as BRCA1/2 protein, FANCD2 nuclear foci formation and expression of miR 155.
OUTLINE: This is a multicenter, dose-escalation study of veliparib.
Patients receive carboplatin intravenously (IV) over 1 hour on day 1 and veliparib orally (PO) twice daily on days 1-7 or 1-14. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity. Patients may undergo fluorothymidine PET scan and peripheral blood cell and tumor tissue collection periodically for correlative studies.
After completion of study treatment, patients are followed up for 12 weeks.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
Patients must have histologically or cytologically proven metastatic or locally advanced inoperable breast cancer that fulfills one of the following two criteria:
- Triple-negative breast cancer
- ER and/or PR positive, HER2 negative if their tumors have been shown to be deficient for the FA pathway, based on FA triple stain immunofluorescence (FATSI) screening
HER negative with a known germline BRCA1/2 mutation
- Patients with ER- and/or PR-positive breast cancer will be consented to have their existing, or to be obtained, paraffin-embedded tumor tissue screened for FA deficiency
- No more than 3 prior chemotherapy regimens for metastatic disease will be allowed; any number of prior hormone therapies will be allowed; however, at least 4 weeks should have elapsed since prior chemotherapy (6 weeks for mitomycin C and nitrosoureas and 2 weeks for hormone therapy) or radiation therapy (2 weeks for limited field palliative radiation to the bone)
- Eastern Cooperative Oncology Group (ECOG) performance status =< 2 (Karnofsky >= 60%)
Patients with treated brain metastases and life expectancy of greater than 3 months allowed
- Patients with uncontrolled central nervous system (CNS) metastasis are not eligible
- Patients with known Gilbert syndrome with abnormal unconjugated bilirubin will be eligible
- Absolute neutrophil count >= 1,500/mcL
- Platelets >= 100,000/mcL
- Total bilirubin within normal institutional limits
- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic acid transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 X institutional upper limit of normal
- Creatinine within normal institutional limits OR creatinine clearance >= 60 mL/min/1.73 m^2 for patients with creatinine levels above institutional normal
- No prior therapy with veliparib for metastatic disease will be allowed
- Women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation
- Ability to understand and the willingness to sign a written informed consent document
- Patients must be able to swallow pills
Exclusion Criteria:
- Patients who have had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
- Patients may not be receiving any other investigational agents
- History of allergic reactions attributed to compounds of similar chemical or biologic composition to veliparib or other agents used in study
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with veliparib
- Known human immunodeficiency virus (HIV)-infected patients on protease inhibitors (HIV-infected patients with adequate CD4 counts [> 500] and not on protease inhibitors are eligible)
- Patients with active seizure or a history of seizures are not eligible
- Patients with uncontrolled CNS metastasis are not eligible; patients with CNS metastases must be stable after therapy for > 3 months and off steroid treatment prior to study enrollment
|United States, District of Columbia
|Lombardi Comprehensive Cancer Center at Georgetown University
|Washington, District of Columbia, United States, 20057
|Contact: Claudine Isaacs 202-444-3677 firstname.lastname@example.com
|Principal Investigator: Claudine Isaacs
|United States, New York
|Montefiore Medical Center
|Bronx, New York, United States, 10467-2490
|Contact: Eleni Andreopoulou 718-904-2555 firstname.lastname@example.com
|Principal Investigator: Eleni Andreopoulou
|United States, Ohio
|Ohio State University Medical Center
|Columbus, Ohio, United States, 43210
|Contact: Bhuvaneswari Ramaswamy 614-293-6401 email@example.com
|Principal Investigator: Bhuvaneswari Ramaswamy
|Principal Investigator:
|Bhuvaneswari Ramaswamy
|Ohio State University
No publications provided
|Responsible Party:
|National Cancer Institute (NCI)
|ClinicalTrials.gov Identifier:
|NCT01251874 History of Changes
|Other Study ID Numbers:
|Study First Received:
|December 1, 2010
|Last Updated:
|March 20, 2014
|Health Authority:
|United States: Food and Drug Administration
Additional relevant MeSH terms:
Breast Neoplasms
Breast Neoplasms, Male
Neoplasms by Site
Breast Diseases
Skin Diseases
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
ClinicalTrials.gov processed this record on April 22, 2014


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This ambulance was manufactured in Indiana in February 1941, before the US entered WWII. It is typical of the type of vehicle that would have been in service at Pearl Harbor on December 7, 1941; so I used unit markings of the station hospital at Hickam Field to honor my Uncle who was a Pearl Harbor survivor.
1941 Dodge WWII Ambulance
By: altohorn2Subscribe Channel: Cars Location: Bloomington, IL
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Financial figures rise; information systems business remains relatively flat
Sales rose 4 percent, from $8.35 billion in the third quarter of 2009 to $8.7 billion this year. Its reported net income for the third quarter of 2010 increased from $490 million in 2009 to $497 million. And its earnings from continuing operations increased to $489 million, up from $464 million in 2009, according to the company's financial report.
"Third-quarter results demonstrate that our focus on sustainable performance improvement continues to gain traction across the corporation. All our businesses performed well," said Wes Bush, president and CEO of Northrop Grumman.
While Northrop's financials rose, its information systems business segment remained relatively flat compared to 2009, with $2.123 billion in sales in 2010's third quarter compared to $2.118 billion in 2009, for a 0.2 percent increase. However, for the first nine months of 2010, sales slipped 1 percentage point, falling to $6.310 billion this year from $6.362 billion in 2009.
In the third quarter of 2010, Northrop Grumman saw increased sales in defense systems, but they were largely offset by lower sales of intelligence and civil systems programs.
Like other corporations, Northrop Grumman is streamlining its operations to reduce expenses wherever it can. In the third quarter, operating income increased 13 percent and as a percentage of sales totaled 8.9 percent compared to 7.9 percent in the third quarter in 2009. The figures reflect an improved program performance for civil systems, the company said.
Northrop's electronic systems segment increased 2 percent in 2010, rising from $1.839 billion in 2009 to $1.874 billion. Sales over the first nine months of 2010 also rose 3 percent compared to 2009, from $5.594 billion last year to $5.740 billion.
Northrop Grumman, of Los Angeles, ranks No. 2 on Washington Technology's 2010 Top 100 list of the largest federal government contractors.
About the Author
Matthew Weigelt is a freelance journalist who writes about acquisition and procurement.
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Santa Claus will visit Youth Health Services Dec. 7 to take free pictures with children.
The "Cookies with Santa" event will be offered from 2-3:30 p.m. at the Youth Health Services offices at 971 Harrison Ave. in Elkins.
Parents may bring their cameras. The event will feature cookies, hot chocolate and coffee for all to enjoy, and each child will receive a special treat.
The event is sponsored by the Home Ties Strengthening Families Center. For more information, call J.J. Johnson at 304-636-9450.


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Inspired by 18th- and 19th-century dinnerware found in Parisian flea markets, these mixing bowls are great for food prep or serving. And because they're microwave safe and dishwasher safe, they're just as practical as they are stylish.
Vibrant and yet rustic, timeless and yet fresh, creations from Tag are an easy way to add color, style, and even joy to your abode.


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Contact: Public Information Office
(301) 763-3030 (phone)
(301) 763-3762 (fax)
According to the latest 2010 Census mail participation rates released today, the state of Georgia has now matched the rate it had achieved during the 2000 Census — 69 percent. Georgia is one of 19 states, in addition to Washington, D.C., and Puerto Rico, that have met or surpassed their rates from the 2000 Census.
The Census Bureau will continue to post updates to the participation rate throughout the week as the last of the mailed-back forms are processed. After Friday, April 23, no rate updates will be posted until the final mail participation rate is calculated and announced at a news conference during the week of April 26.
The complete list of states that have reached this milestone follows:
The 2010 Census is a count of everyone living in the United States and is mandated by the U.S. Constitution. Census data are used to apportion congressional seats to states, to distribute more than $400 billion in federal funds to tribal, state and local governments each year and to make decisions about what community services to provide. The 2010 Census form is one of the shortest in U.S. history, consisting of 10 questions, taking about 10 minutes to complete. Strict confidentiality laws protect the respondents and the information they provide.


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by Betsy Taylor
Winter 2004
Whether you are an avid wilderness hiker or an urban bird lover, you have surely noticed disturbing changes in the natural landscape. The losses and threats to our environment are evident from coast to coast. Countless farms and streams are forever gone. Fresh water is growing scarce in parts of the American West. Forests from Tennessee to Oregon have been logged at an alarming rate and air quality is below EPA standards in many urban areas. Climate change, and its capacity to disrupt natural ecosystems, looms ever larger.
We all know the bad news. But what do each of us know about how personal consumer choices can contribute to the problem … or the solution?
First the problem: The Earth is out of balance and our consumption of resources is a root cause of the problem. It seems everything but the planet is getting bigger: television screens, houses, vehicles, bathtubs, burgers, candy bars, waistlines and credit card debt. Meanwhile wilderness areas, grasslands and underground aquifers continue to shrink.
There is a connection. With just 5 percent of the planet's global population, Americans consume some 30 percent of the world's material resources and 40 percent of the gasoline. If everyone consumed like the average American, some scientists predict that we would need at least four more planets to provide the necessary resources and absorb the waste.
Our work-and-spend consumer lifestyles not only contribute to the decimation of planetary resources, they also contribute to personal and family stress. Consumer spending has been rising for decades. Yet polls indicate that we are not getting any happier. Indeed, after a certain level of material security is achieved, there is little correlation between expansive lifestyles and increased contentment. Nowadays, a typical couple spends 12 minutes a day in actual conversation, apart from getting laundry done or talking logistics. Average working parents spend just 40 minutes a week playing or being with their children in a non-goal or task-oriented way. In short, many Americans have more stuff … but less fun.
Last year, some 1.6 million families went too far with the "buy now, pay later" approach to life and had to declare bankruptcy. Nearly one-half of all Americans don't get enough sleep and, each year, Americans on average work 350 hours – nearly nine weeks – more than Europeans. Three in five Americans report feeling pressure to work too much, and in an August 2004 survey, one in two Americans reported that they would willingly accept less money in exchange for more time.


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I don't think he deserves to be "in the discussion" this year because of how superd Fernandez has been, but in a lot of seasons Tony Cingriani's rookie season for the Redlegs would put him in contention for the RoY. In fact he may be the NL rookie that has had the most "important" season considering where the Reds would be without him.
Top 10 September storylines to watch
The final month of the 2013 season is underway, and while there might be less suspense than we'd prefer with regards to the postseason field — nine teams currently have at least a 95 percent chance of playing into October according to the Baseball Prospectus Playoff Odds – that doesn't mean there's a shortage of stories to follow in September. Here's a selection of the month's top 10 storylines:
1. The end of the Pirates' long drought
Since winning the NL East three straight times from 1990 to '92, the Pirates have not only failed to make the playoffs, but they've also failed to crack .500 for 20 straight seasons. That streak of futility, the longest in any major North American team sport, is about to end. On Monday, Pittsburgh won its 80th game, surpassing the high-water mark of the team's inglorious run (set in 1997 and matched last year), and leaving the Pirates just one victory short of clinching .500. They Bucs have 25 games to not only secure a winning record, but also to make the playoffs (they currently have a 99.9 percent chance of reaching the postseason). Though they've gone just 29-27 since the beginning of July, their recent additions of right fielder Marlon Byrd and first baseman Justin Morneau have strengthened the lineup. The impending return of closer Jason Grilli from a forearm strain should help as well.
LEMIRE: The five X-factors that will help decide the playoff races
2. The three-way race in the NL Central
The NL's most hotly-contested division bears watching given the likelihood that it will yield both of the league's wild-card teams. Entering Tuesday's action, Pittsburgh (80-57) holds a one-game lead over the Cardinals (79-58) and a 3 1/2-game lead over the Reds (77-61). The BP odds narrowly favor the Bucs to win the division (44.2 percent to the St. Louis's 41.0 percent), and they give just a 2.1 percent chance for another NL team — either the Diamondbacks or Nationals — to crash the postseason party. Cincinnati and the Pirates play each other six times over the seasons' final nine games, while the Cardinals, after their final series against Pittsburgh (Sept. 6-8), have something of a cakewalk: six games against the Brewers and three apiece against the Mariners, Rockies, Nationals and Cubs.
CORCORAN: Must-attend games that will decide playoff spots
3. The A's/Rangers battle in the AL West
Last year, the A's overcame a five-game deficit with 10 to play to snatch the AL West flag away from the Rangers — who had led the division since April 9 — on the season's final day. This season, the two teams have jockeyed for position in more balanced fashion, with Texas holding at least a share of first place 92 times, and Oakland doing so 71 times. On Monday, the A's opened a three-game series against the Rangers in Oakland with a 4-2 victory, putting the two teams into a tie for the sixth time this year.
Both teams have struggled with injuries, but are in better shape of late. In the past week, the A's have gotten pitchers Bartolo Colon and Brett Anderson back from the disabled list, with the latter working in relief. They also shored up their decimated catching corps by reacquiring Kurt Suzuki from the Nationals on Aug. 23; he's gone 7-for-18 with three extra base hits since. Meanwhile, the Rangers activated DH/first baseman Lance Berkman (out since July 6) and pitcher Neftali Feliz (out since May 18, 2012) from the disabled list on Sept. 1. The two teams will meet in one more three-game series, in Texas from Sept. 13-15.
4. Miguel Cabrera's attempt to top his Triple Crown-winning season and secure a second straight MVP award
Last year, the Tigers slugger became the first player since 1967, and just the 14th since 1900, to lead his league in batting average (.339), home runs (44) and RBI (139). With just under four weeks to go, he has a very good chance to improve upon all those numbers, in addition to improving on his on-base and slugging percentages (.393 and .606, the latter a league-leading mark as well).
To become the first player ever to win a second consecutive Triple Crown, Cabrera will have to come from behind in a major category, just as he did last year, when he trailed in both batting average and home runs in September. This year, his 43 home runs are four fewer than Baltimore's Chris Davis. Cabrera does top the AL with 130 RBI and he's hitting .358/.449/.681, good for the league lead in all three categories (the so-called slash-stat Triple Crown). His 6.9 WAR is short of last year's 7.3, and he may not catch Mike Trout (8.2), but so long as he can stay in the lineup — something he's had difficulty doing over the past six weeks due to a variety of ailments — he could bring home more hardware this winter.
5. Chris Davis' pursuit of Roger Maris' AL single-season home run record
The 27-year-old Orioles slugger leads the majors with 47 home runs. He's hit just three in his past 17 games, though, and has fallen off the pace to surpass the 61 homers that Maris hit in 1961. (The three men who bested Maris's record — Barry Bonds, Mark McGwire and Sammy Sosa — all played in the National League.) At the moment, Davis projects to finish with 56 home runs, but his penchant for hitting them in bunches — seven in a six-game span late last year, homers in four straight games to start this season, seven in a nine-game stretch in mid-June, and so on — could get him back on track in a hurry. Given that his top output for any month is 12, he faces an uphill battle, but even if he doesn't hit the mark he can still help Baltimore to a playoff spot, or himself to an MVP award.
6. Clayton Kershaw's pursuit of the NL Cy Young and MVP awards
As I pointed out recently, Kershaw's strong second half has enhanced his case to sweep the NL's two major awards, something no pitcher in that league has done since 1968; in the interim, seven AL pitchers have done so, the last of whom was the Tigers' Justin Verlander in 2011. Even after being roughed up for five runs by the Rockies on Monday, Kershaw owns a league-best 1.89 ERA; he also leads in innings (209) strikeouts (201) and Wins Above Replacement (7.2), outdistancing the Pirates' Andrew McCutchen (7.0) and every other position player in the league.
CORCORAN: Examining the big debates in the AL and NL MVP races
7. The final month of Mariano Rivera's stellar career
Despite a notable hiccup last month — a streak of three straight blown saves for the first time in his 19-year career — Rivera has excelled at age 43. He has a 2.16 ERA and a 4.9 strikeout-to-walk ratio to go along with 39 saves, increasing his record total to 647. His farewell tour has been something special to behold, not only with opposing teams paying tribute by bestowing gifts upon him but with the man himself taking time to meet with team employees and fans at each stop — a class act to the very end.
The only question now is whether Rivera will get a chance to add to his postseason record of 42 saves. The Yankees are 2 1/2 games out of a wild-card spot and in danger of missing the playoffs for just the second time in his career; their BP odds of Rivera playing into October are just 11.0 percent.
GALLERY: Mariano Rivera farewell tour gifts
8. The NL Rookie of the Year battle between Jose Fernandez, Julio Teheran and Yasiel Puig
When writing about the Senior Circuit's rookie race less than two weeks ago, colleague Cliff Corcoran declared that Fernandez, the Marlins' phenom, "deserve[s] to win in a landslide." Indeed, it's tough to assail his credentials. He's an electrifying 21-year-old righty who leads the league in strikeout rate (9.8 per nine), and ranks third in both ERA (2.33) and WAR (5.5). The one thing that could leave the door open for another candidate is his impending shutdown; with 158 2/3 innings under his belt, he has just two starts and a maximum of 12 innings remaining before Florida wraps up on him.
The 22-year-old Teheran hasn't been quite as strong as Fernandez, but he does have a 3.01 ERA, 8.3 strikeouts per nine and 3.1 WAR — all tops among Braves starters — in 161 1/3 innings. As he nears his previous career high of 164 1/3 innings (set in 2011 between the minors and majors), Atlanta plans to push back his next start to Sept. 10. In all likelihood, he'll still be standing when the season ends, and could close the gap on Fernandez.
Less likely to be reined in — in any sense of the word — is the 22-year-old Puig, who entered Monday hitting .351/.411/.564 with 14 homers in just 80 games. Even as controversy swirls around him, the human highlight film has found a way to help the Dodgers in some capacity virtually every day. Take this past weekend's series against the Padres, which began one day after manager Don Mattingly had pulled him from Thursday's game against the Cubs for a lack of preparedness. Puig went 4-for-5 in a 9-2 rout of San Diego on Friday, threw out a runner at home in 2-1 win on Saturday (offsetting his 0-for-4 at the plate with three strikeouts) and hit the go-ahead homer in another 2-1 win on Sunday.
Despite not debuting until June 3, after Los Angeles had played exactly one-third of its season, Puig's 4.7 WAR leads the team's position players and is tied for eighth among all major league outfielders. Oh, and the Dodgers are 57-23 (.713) in games in which he has played.
9. The returns of Clay Buchholz and Matt Moore
The Red Sox have the American League's best record (82-57) and a 5 1/2-game lead on the Rays (75-60) despite the fact that Buchholz, their most effective starter this year, hasn't pitched in a game since June 8. When he did pitch, he was outstanding, with a 1.71 ERA and 8.6 strikeouts per nine innings in 12 starts. But trapezius and shoulder troubles sent him to the DL. While the addition of Jake Peavy (3.18 ERA in six starts) and the improvement of Jon Lester (2.56 ERA in eight second-half starts) has taken the pressure off John Lackey and Felix Doubront, the team's postseason rotation would be more formidable if Buchholz could return to something near his early season form. He's planning to make one more rehab start before rejoining Boston on Sept. 10 — against Tampa Bay, no less.
As for Moore, after tossing a two-hit shutout in Fenway Park on July 22, he made just one more start before going on the DL due to elbow soreness. He's scheduled to return against the Angels on Tuesday night. In 21 starts, he has a 3.41 ERA while striking out 8.5 per nine innings, tops among Rays starters. His return to the starting five alongside David Price, Chris Archer and Alex Cobb means that either Roberto Hernandez (4.95 ERA), Jeremy Hellickson (5.21 ERA) or rookie Jake Odorizzi (5.09 ERA in four starts and one relief appearance) will have to fill one spot instead of two, and can be dropped if the team makes the playoffs.
10. The potential resolution of the Mike Scioscia/Jerry Dipoto clash in Anaheim
Last week — with the Angels (64-72) headed for just their second sub-.500 finish since 2003 and their fourth straight missed postseason — a rumor surfaced that owner Arte Moreno would shake things up by dismissing either his manager (Scioscia, on the job since '00 and signed through '18) or his general manager (Dipoto, on the job since November '11), who are rumored to have clashed over personnel and philosophies.
Despite signing big-ticket free agents Albert Pujols, Josh Hamilton and C.J. Wilson — both Pujols and Hamilton have been extremely disappointing thus far — over the past two offseasons and reaping the benefits of Trout's historic rise, the Angels' stars-and-scrubs roster has become less competitive. The situation may not be resolved in September at all, but a respectable showing could strengthen Scioscia's hand, while a continued slide could spell the exit of the longest-tenured manager in the majors.
The addition of Byrd and Morneau to the Pirates lineup cannot
be understated. Last night Morneau had 3 hits and Byrd had
2 hits and the Bucs won a game in come frm behind
fashion in Milwaukee, previously a house of horrors for them over
the last 7 years.
They wouldn't have won that game last year, last month or last week.
I don't understand how someone, (Kershaw) who only plays every 5 days can be considered most valuable.
Thats why they have the Cy Young Award! MVP should be for position players only.
Nice story-line for September, Jay. Sure is nice to be able to predict those story lines before they unfold. Cabrera has made Corcoran eat so much crow this year and last! The article you refer to for the slash-stat Triple Crown (might have been better to give us a gallery of Miggy hitting home runs on one leg in August!), is another example of Corcoran bombastically proclaiming that Hamilton would keep Cabrera from winning the Triple Crown last season! Wrong, again, Cliff! At least this year, by your very own measurements, Cabrera has already won it! Meh, I will take the traditional Triple Crown over any redefinition of same! Miggy might still get it, and, that is story line number one across all markets, and, all Baseball! The MVP is a given already, even if he goes on rehab all of September!


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Cleaning Interior Walls
June 5, 2010 by stain remover expert No Comments »
Beat until Leatherwood Creek. When May fades in the calendar, go hiking options to decrease slightly. Trails get invaded heat and humidity in June to become arrogant, Poison Ivy and snakes through the earth and clouds of mosquitoes that can not pass Deet Valley fever.
General Housekeeping : How to Clean Painted Walls
Posted in: Cleaning Solutions


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– Top-ranked North Georgia began their quest for a National
Championship on Thursday afternoon, using timely hitting and
stellar defense to top Molloy College 4-0 in the opening game of
the 2010 NCAA Division II National Championships at Heritage
North Georgia's unbeaten run continues, as the team is now 51-0 and advance to Friday's round of the NCAA Division II National Championships at 4:00 p.m. CST against Valdosta State University. The Saints are now 3-2 all-time in the Division II World Series, and 2-0 in opening-round contests.
Molloy, making their first appearance in the National Championships, fall to 43-20 on the year and will make their way to the loser's bracket and Saturday's consolation round of the tournament.
Molloy threatened in the opening inning as the leadoff hitter walked, and Jeana Frey followed with a bunt single to put a pair on with no outs. Following a force play at third for the first out of the game, a wild pitch moved the runners to second and third with just one out.
North Georgia then put together a dazzling defensive play as a grounder to the right side was stabbed by Laura Voyles, and after throwing to first for the out, Katherine fired a strike to third, forcing a rundown between third and home and Kasey Knight finally applied the tag to end the inning and the Lions' first-inning threat.
Voyles stepped to the plate in the bottom half of the first inning and picked up right where she left off in the Southeast Super Regionals, belting the fourth pitch she saw over the fence in left-center, a solo blast to give the Saints the lead at 1-0. Courtney McGuire added to the North Georgia lead in the fourth inning as the senior skied a ball to right field that caught the wind and inched out of the park, giving the Saints their second solo shot of the game and making it a 2-0 advantage.
North Georgia added to their lead in the fourth inning as Lauren Dykes reached base on an infield single and stole second before being lifted for Jessica Skeels who came around to score on a triple of the bat of McGuire, her second hit, and second RBI of the game. Hilary Cox stepped to the plate two batters later and laced a single to right field, sending McGuire trotting home and extending the Saints lead to 4-0.
Sarah Phillips picks up her 10th win of the postseason, as the junior is now 44-0 on the year, tossing her 39th complete game of the year, and 23rd shutout of the season. She allowed just three hits in all 7.0 innings of work, while walking two and striking out six.
North Georgia is now just four wins shy of tying the NCAA's all-time mark for consecutive wins, while moving three wins away from becoming the first softball team in history at any level to capture a National Championships with a perfect record.
North Georgia Head Coach
Mike Davenport:
(Opening Comments) "I want to tip my hat to Malloy, they battled from first pitch on, I mean we got out of a big jam in the first inning – I thought that was important to get out of there without giving up any runs on the board. Their left-handed pitcher, [Butterworth], she baffled us. You've got to tip your hat to her, what a job – comes in their first time in the World Series – and strikes out nine of our kids. It would have been different if I felt we had a chance on those strike outs, but we weren't even close."
"I think later in the game when we finally adjusted and started going to right field with our bats I think that is what finally got us on the board."
"I'm sure she would love to have that pitch back, the one to Laura [Voyles] in the first inning, it was a change-up and she just left it up. Laura does a great job leading off ballgames for us and putting us on the board early. It gives us a pretty good shot."
(On getting off on the
right foot) "From the outside, people keep talking
about our record and our ranking – and that is something they
deserve and have earned, but that can't be taken away.
All eight teams have a shot – you have a one in eight chance
in winning this thing."
"The ultimate goal is to walk out of this thing Monday night holding the trophy – you can do that with a loss. I'll trade you a loss as long as we can keep playing tomorrow – these kids will hopefully buy into that and keep going to battle.
Senior Second baseman Laura
(On Scoring in the first innings) "It was pretty good – we had big momentum going into that first inning as far as offense, because we got the big double play at the end [of the top half of the inning], so it kind of pumped up our confidence. I got in the box just trying to keep the momentum up"
(On finding success at the plate) "We stepped into the box too anxious instead of waiting for our pitch and what pitch we wanted to pitch instead of swinging at her rise ball, her drop ball, or change-up and taking it to right field."
(Her opening at-bat home run) "It was amazing. Just to get our team up one run. We are a great hitting team and no matter what pitcher is on the mound, whether they throw 80 or 45, we are a strong offensive team and we will score some runs."
Junior Pitcher Sarah
(On her performance) I went out in the first inning and started off the game with a four pitch walk – which is never the way you want to start a game – but I always have confidence in my defense."
"I feel like I have the strongest defense in the country. They are unbelievable and today they proved it. Kathryn Martin, our first-baseman, stopped a ball going from the outfield that would have scored a run and made the play at first. Courtney [McGuire] throws a girl out from right field. It's just those kind of plays that make our team who we are and get us those wins."
Senior Right Fielder
Courtney McGuire
(On finding success at the plate) "I think watching the whole line-up go through the first two innings and seeing how she has thrown really helped. We took her strong pitches to right field. We listened and we performed."


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Here's a taste of what's in store…
Travel by steam in traditional carriages across Yorkshire's beautiful countryside. Leaving York in the morning collecting passengers on a circular route calling at Normanton, Wakefield Kirkgate, Wakefield Westgate, Woodlesford, Castleford arriving in York then on to Scarborough. You may choose to spend the day in York or extend your journey to Scarborough, returning early evening.
Below are some highlights of this memorable trip and a detailed map of the route.
The Scaborough Spa Express has many options available with the choice of either York or Scarborough as your destination.
York is a place of contrasts, a medieval walled city with the ancient shops of the 'Shambles', the magnificent Minster, historic churches, intriguing museums and offering the best of modern shopping. In fact something for everyone!
If York is the northern heritage capital of England, Scarborough surely offers the best in British seaside entertainment.
Wide sandy beaches, popular attractions, a ruined castle, a miniature railway and some fine seafront walks offer a great day out for every member of the family.
Whichever destination you choose, once you have alighted from the "Scarborough Spa Express" at either York or Scarborough you can be assured of some of Britain's finest holiday attractions and entertainment. You will have also enjoyed a thrilling means of transport that's a great experience for both young and old – and don't forget to say "Hello!" to the driver!
Through the large picture window of the vintage carriages you can enjoy the beautiful views of the Yorkshire countryside
There is a buffet on every train offering hot and cold drinks, sandwiches and snacks.
Leaving York in the morning collecting passengers on a circular route calling at Normanton, Wakefield Kirkgate, Wakefield Westgate, Woodlesford Castleford, arriving in York then on to Scarborough.
Children (under 16 YO) travel free with a paying adult in Std class seats. In First class seating Child prices apply
1 adult traveling in std class seating with 2 children will only pay for 1 adult and 1 child. - 2 adults traveling with 2 children in std class seating will only pay for 2 adults.
Scarborough Spa Express only


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Vattanapisit Leads XU to Second Place
Vattanapisit Medals at Rutherford
Musketeers in Pursuit of Rutherford Invite Title
Xavier makes final push tomorrow in Happy Valley
Men's Golf Finishes Second At Detroit Golf Club Invitational
Three Musketeers Among Top Eight Finishers
Musketeers Conclude Pinehurst Invite in 12th
Korey Ward Fires a One-Under-Par Final Round
Men's Golf Sit in 10th After Day Two
Musketeers will Tee Off at 9 a.m. Tomorrow
Summer of 2012: First alternate at the U.S. Amateur Qualifier after shooting a 140 (66-74) ... Made the round of8 at the District Amateur Championship.
2011-12: Participated infive events for the Musketeers in his rookie season ... His first event as a Musketeer came at the Cobra Puma Invitational where he fired rounds of 76-70-76---222 (+6)... Opened up the spring season at the Bash at the Beach where he was the second finisher for Xavier with a 4-over-par 220 (74-72-74) ... Was named A-10 Rookie of the Week after his performance at the Bash at the Beach.
Before Xavier: Captured the 2010 Maryland State Public School Championship after firing a 1-under-par 144 ... Named to the Montgomery County Gazette's All-Gazette Team as well as the Gazette Player of the Year following his senior campaign ... Earned third place at the Montgomery County Districts with a 3-over-par 75 ... Recorded the county's low-average three times ... Recorded three top-15 finishes during the summer of 2010 on the AJGA circuit including finishing in a tie for seventh at the Junior at River Creek.
Personal: A finance major ... born February 15, 1993 in North Potomac, Md.... son of Skip and Susan Tendall ...Father played golf at Arizona State and his brother played at Illinois.


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You're leaving Wedding Paper Divas to see the Deal of the Day at our parent site, Tiny Prints.
You won't be able to dismiss this by usual means (escape or click button), but you can close it programatically based on user choices or actions.
"This card was perfect for our wedding because it is simple, yet classy. The card looks exactly like it does on the website. I put a picture on the back of the card and it looks good. I would definitely recommend this product and would be happy to order from this company again in the future."
"Thanks so much to wedding paper divas for my invites. I love the design, layout and help was flawless. I appreciate the attention to detail, online chat option and wonderful customer service. Great product and wonderful service."
"We love how our wedding invitations turned out. We went with the wreath in yellow. We played with the fonts, I preferred lower case with a more modern feel. Wedding paper divas makes it easy to customize and their staff helped us with font uniformity and spacing too. We also included our parents names inside the wreath. I recommend ordering the wood back to give it a more natural feel. Looks great!"
"I ordered this invite as well as other suite items that include the response card and enclosure card. I had a custom accent color and it turned out great. I needed an additional enclosure card for inviting certain people to the rehearsal dinner and was able to take the design from the Save the Date card and make it into an enclosure on the same paper as the other items. The designer I worked with was fantastic. I also recommend putting the wood print on the back of all the items. It looks much nicer than plain white and there was no extra charge for this. The envelopes were a bit on the cheap side, but they did cut down on weight. The total weight for the invite, 2 enclosure cards, response card and envelopes was just at 1 oz so I could use a regular stamp and didn't have to go up to the $.66."
"We used a few pieces from this suite for our wedding invitations and I'm very happy with them! The paper is absolutely gorgeous and thick. The flower design is unique and we are actually using it on all of our paper goods. And customer service at WPD is top notch!"


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What's on: Wildlife Photographer of the Year Exhibition
Experience the power, mystique and beauty of nature through the wildlife photographer's lens.
- Event Type:
- Special event
- Date:
- 29 March 2014 to 1 June 2014
- Time:
- 09.30 AM to 05.00 PM
- Location:
- Level 2, Special Exhibition Space
- Admission:
- Free after admission
Be captivated by curious lions, fighting vultures, dancing dolphins and frolicking baby crocodiles playing with their mother.
See 100 powerful images selected from more than 40,000 entries worldwide and discover the amazing world we live in. Australian photographer, Justin Gilligan, is among those honoured in the highly renowned international competition.
The photographs exhibited in the Wildlife Photographer of the Year (WPY) are increasingly important for the way they highlight pressing environmental issues such as animal extinction and destruction of natural landscapes.
For a limited time only.
To stay in the loop about great exhibitions like this, sign up to our Events e-newsletter:
Last Updated:


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Book your room at Mahekal Beach Resort
Standard Garden ViewMax Occupancy: 4 adults
Standard Palapa Garden ViewMax Occupancy: 4 adults
Standard Ocean ViewMax Occupancy: 4 adults
Standard Palapa Ocean ViewMax Occupancy: 4 adults
Standard Ocean FrontMax Occupancy: 4 adults
Beachfront bungalow-style, palapa-roofed resort in the heart of Playa del Carmen
On the beach
This beachfront hotel is located in Playa del Carmen, 3 minutes from the famous 5ta Avenida, right on the beach.
2 restaurants, bar/lounge
In addition to 2 outdoor swimming pools, Mahekal Beach Resort features restaurants, a concierge desk, and a new Spa.
In keeping with our style, our rooms do not offer televisions, radios or telephones.
Balconies, ocean views
Guestrooms open to balconies with ocean, garden or pool views and feature lanais. Other amenities include patios with hammocks, ceiling fan and air conditioning.Information missing or incorrect? Tell us!
Mahekal Beach Resort
- At your hotel
Mahekal Beach Resort has 2 restaurants and also features a bar/lounge. A complimentary breakfast is served each morning. High-speed wireless Internet access is complimentary. An internet point is on site at this 3.5-star property. Mahekal Beach Resort features 2 outdoor swimming pools. This beach hotel also offers an outdoor pool, spa services, and a concierge desk. Wedding services and tour/ticket assistance can be provided. Onsite parking is complimentary. Mahekal Beach Resort is a smoke-free property.
- Free parking
- Self parking
- Total number of rooms - 121
- Number of floors - 2
- Babysitting or childcare
- 24-hour front desk
- Beauty services
- Currency exchange
- Free Wi-Fi
- Internet point
- Arcade/game room
- One meeting/conference room
- Laundry facilities
- Multilingual staff
- Garden
- Beach umbrellas
- Beach towels
- Free guest parking during stay
- Number of buildings/towers - 16
- Bar/lounge
- Wedding services
- Concierge desk
- Doorman/doorwoman
- Gift shops or newsstand
- Beach/pool umbrellas
- Number of outdoor pools - 2
- Billiards or pool table
- Tours/ticket assistance
- Massage - spa treatment room(s)
- Medical assistance available
- Pool table
- Security guard
- Smoke-free property
- Spa services on site
- Stay connected
Available in some public areas: Free Wi-Fi
- Park your car
Free parking, Free guest parking during stay, Self parking
- In your room
- Air conditioning
- Complimentary bottled water
- Private bathroom
- Hair dryer
- Shower only
- Desk
- Patio
- Access via exterior corridors
- Climate control
- Ceiling fan
- Daily housekeeping
- Complimentary toiletries
- Connecting / adjoining rooms available
- Iron/ironing board (on request)
- In-room safe
- Eat and drink
Mahekal Beach Resort has 2 restaurants serving breakfast, lunch, and dinner. Guests are offered a complimentary cooked-to-order breakfast. The Spa offers massages, facial and body treatmens, manicure and pedicure.
- Play
2 outdoor swimming pools are on site. The recreational activities listed below are available either on site or nearby; fees may apply.
- Sailing nearby
- Boat launch nearby
- Motor boating nearby
- Windsurfing nearby
- Whale-watching nearby
- Parasailing nearby
- Fishing nearby
- Water skiing nearby
- Ecotours nearby
- Bungee jumping nearby
- Scuba diving on site
- Snorkeling on site
- Surfing/boogie boarding on site
- Swimming on site
- Table tennis on site
- Volleyball on site
- Relax
Mahekal Beach Resort offers spa services and massage/treatment rooms.
- Number of treatment rooms 2
- Massages on beach
- Manicures and pedicures
- Body wraps
- Body treatments
- Facial treatments
The Fine Print for Mahekal Beach Resort
- When you arrive
Check-in time starts at 3 PM
Minimum check-in age is 18
- When you leave
Check-out time is 1 PM
- How you can pay
Accepted at this hotel: American Express, MasterCard, Visa
- Your furry friends
Pets allowed
- You need to know
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Fees
- The following fees and deposits are charged by the property at time of service, check-in, or check-out.
The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.
- A late check-out fee will be charged
- Deposit: USD 115 per week
- Refrigerator fee: USD 10 per night
- We Should Mention
Reservations are required for massage services and spa treatments. Reservations can be made by contacting the hotel prior to arrival, using the contact information on the booking confirmation. Children 4 years old and younger stay free when occupying the parent or guardian's room, using existing bedding. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


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A 9-month-old boxer pup named Duncan barrelled down a beach in Oregon, running full tilt on soft sand into YouTube history and showing more than 4 million viewers that he can revel in a good romp despite lacking back legs.
If dyeing Easter eggs with vinegar and colour tablets is feeling old, reach for a new duo: shaving cream and liquid food coloring.
Chomping down on a rosette of freshly emerging tulip leaves is just the thing to drive away winter doldrums — for deer. Crocuses probably taste almost as good to them.
Ham and Easter go hand in hand. If you'd like to make your family meal a bit more snazzy this year, these two ham recipes are a good place to start. Mimosa Ham gets its name from the orange and sparkling wine used to season the meat. Our Cranberry Glazed Ham proves that cranberry sauce isn't the exclusive domain of Christmas holiday entertaining, and that it can pair well with a meat other than turkey. Because you can't just serve ham, we're included a recipe for Herbed Popovers, a bun-like side that's made as a batter, not a dough. The cooking method is unique, but the savoury, airy popovers are a nice touch on the dinner table.
Fashion fans have been watching every move by the Duchess of Cambridge on her recent tour of New Zealand and Australia.
The idea of packing up and settling in Paris for a life where days are spent picking out fresh produce from markets lined up on cobblestone streets and stopping to select a few nice cheeses from the endless array at the fromagerie to go with a fresh baguette is very tempting. Few of us will make that leap.


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Updated Nov 19, 2012 - 5:03 pm
ASU's Graham knows importance of rivalry game
It took Arizona State head football coach Todd Graham less than 45 seconds at his weekly Monday press conference to use those words when describing the Sun Devils' game against rival University of Arizona on Friday.
A Rose Bowl or BCS appearance isn't on the line, but this year's game takes on a different meaning.
You have two schools in Arizona State and Arizona that are in almost identical situations. The teams' previous regimes -- with Dennis Erickson and Mike Stoops -- were disappointing, both peaking with Holiday Bowl bids when more was expected.
It's the beginning of a new era for Graham at ASU and Rich Rodriguez at the University of Arizona. Both teams are 4-4 in Pac-12 play and the Wildcats have seven wins overall to the Sun Devils' six.
Friday night brings an opportunity for both coaches to set a tone for their program going forward.
This rivalry game wasn't something from which Graham shied away. He made it clear he knew and understood the importance of winning this game.
"You can be 11-0 and if you don't win this game you had an unsuccessful season," Graham stated. "This is what college football is all about, rivalry games, and none that have more passion than this one."
In these parts, that is all understood. Games between UA and ASU will always be meaningful no matter what the records are. The question is, will this game be the start of the Territorial Cup taking on a bigger presence nationally? Will Graham and Rich Rod live up to their words and their respective schools become relevant on a bigger stage?
Friday night will either be the start of something special or another beginning to the end of failed promises and expectations.
- ASU quarterback Taylor Kelly caps spring with successful scrimmage performance
- Todd Graham pleased ahead of ASU spring football game
- ASU's Mo Latu losing weight and gaining confidence
- ASU A.D. Anderson: New fee gives students more ownership of Sun Devil athletics
- ASU AD: Overtraining still a serious problem for student-athletes
- Ray Anderson, Arizona State athletic director - Thursday April 17Ray Anderson talks about the new athletic fee and what it means for students. Also, what does it mea
- Gary Lane, ASU rugby coach - Friday April 11ASU rugby coach Gary Lane talks about his team's upcoming game against BYU.
- Chris Karpman, ASU Devils.com - Wednesday April 9ASU Devils.com Chris Karpman discusses the new student athletic fee.
- Ray Anderson, Arizona State athletic director - Wednesday April 9Arizona State athletic director Ray Anderson discusses the new student athletic fee.
- Ray Anderson, ASU Athletic Director - Wednesday April 2Ray Anderson discusses ASU spring sports.


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- Caterer's Tablecloth - White $45 – $59
- Free Shipping
- Monogramming Available
- Online Only
Hundreds of new items for the season ahead.
Make a one-on-one appointment with a Design Specialist today.
Inspiration for your big day and every day after.
Find a gift they'll truly cherish.
Beaded detail enhances the comfortable appeal of earthenware, ...
Beaded detail enhances the comfortable appeal of earthenware, lending our Emma Dinnerware the look of an antique set. Created by Barbara Eigen, a well known designer of unique handmade ceramics. Beautiful for entertaining, yet casual enough for everyday use. ...


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Slideshow posted in News | Sunday, June 30, 2013
9 of 148:
Thousands of people braved the heat Saturday to participate in 35th annual Houston LGBT Pride Festival and parade in the Montrose area. The crowd at this year's day-long celebration was even more excited than usual because it happened just days after the Supreme Court made two rulings in favor of same-sex marriage in states where it is legal.
(Photo/iWitness reports)


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I had an epidural with my first ds. I was given it before I went into labor (but after being induced because my water broke) because his heart rate went WAY down. It wore off right *AFTER* the pushing but pretty much before the doctor reached into my uterus over and over and over to check for/remove retained placenta.
So no pain drugs or anything. I remember being REALLY happy when he stopped doing that to stitch up my episiotomy (without pain drugs, mind you), because the stitching felt THAT much better. Him reaching into my uterus was the worst pain I've ever dealt with. Dp finally yelled at them to give me whatever pain drugs they had in the room. lol.
I've been told by a few people that manual removal of placenta hurts worse than birth. Basically, that if I could get through that, then having a baby should be a breeze (not really a breeze, but ykwim)! (My EDD is this month month, btw )
So...anyone here able to confirm or deny that claim?