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read reviews [17]
Makes 16 to 18 sandwich cookies
Oreos used to be a mystery to me. My mom never bought commercial sweets, and she certainly never bought the almost-black cookies that looked burnt to her. For the same reason, they never appealed to me either—until one day when I finally bit into one at a friend's house. Wow. Years later, I created my own version of an Oreo, made with real chocolate and bittersweet cocoa and filled with a creamy mixture of sugar, butter, and a little vanilla. It's a decidedly grown-up version of the treat. And it's delicious. Even Mom approves. When she visits, she always requests them for the care package I send home with her.
In a medium bowl, whisk together the butter and granulated sugar until well combined. Whisk in the vanilla and chocolate. Add the egg and whisk until thoroughly incorporated.
In another medium bowl, stir together the flour, cocoa powder, salt, and baking soda until well mixed. Using a wooden spoon, stir the flour mixture into the chocolate mixture. The dough will start to seem too floury, and you will find it easiest to switch to mixing it with your hands until it comes together. It will have the consistency of Play-Doh. Let the dough sit at room temperature for about 1 hour to firm up.
Transfer the dough to a 15-inch square sheet of parchment or waxed paper. Using your hands, shape the dough into a rough log about 10 inches long and 2-1/2 inches in diameter. Place the log at the edge of the sheet of parchment paper, and roll the parchment around the log. With the log fully encased in parchment, roll it into a smoother log, keeping it at 2-1/2 inches in diameter. Refrigerate for at least 2 hours, or until firm. The log may settle and sink a bit in the fridge, so reroll it every 15 minutes or so to maintain a nice round log, if you like. If not, your cookies will be more oblong than round, which is not a bad thing taste-wise, though they won't look like the famous packaged cookie. (At this point, the dough log can be well wrapped in plastic wrap and stored in the refrigerator for up to 1 week or in the freezer for up to 1 month. If the dough is frozen, thaw overnight in the refrigerator before proceeding.)
Position a rack in the center of the oven, and heat the oven to 325°F. Line a baking sheet with parchment paper or butter it.
Cut the dough log into 1/4-inch-thick slices. Place the slices about 1 inch apart on the prepared baking sheet.
Bake for 20 to 25 minutes, or until the cookies are firm to the touch. Check them frequently after 16 or 17 minutes, poking them in the middle. As soon as they feel firm to the touch, remove them from the oven. You can't judge by color because they start out black. Let cool on the baking sheet on a wire rack to warm or room temperature. They don't have to cool completely before you fill them, but you can't fill them while they are hot.
While the cookies are cooling, make the frosting. Using a stand mixer fitted with the paddle attachment (or a handheld mixer), beat the butter on low speed for about 30 seconds, or until completely smooth and soft. Add the confectioners' sugar and vanilla and beat until the mixture is perfectly smooth. Add the milk and salt and again beat until smooth. It will look like white spackle and feel about the same—like putty. You can also mix this frosting by hand. Make sure the butter is very soft, and use your hands to mix and knead the confectioners' sugar into the butter. You should have about 1 cup. (The filling can be stored in an airtight container at room temperature for up to 2 days or in the refrigerator for up to 2 weeks. Bring to room temperature before using.)
Scoop about 1 rounded tablespoon of the filling onto the bottom of 1 cookie. Top with a second cookie, bottom side down, then press the cookies together to spread the filling toward the edges. Repeat until all of the cookies are filled.
Photo: Keller + Keller
by chefcoach,
8/28/2013I was looking for a homemade oreo cookie recipe to make for my dad and husband who are addicted to the store bought processed version. I also couldn't find one that didn't use vegetable shortening in the filling. Imagine to my surprise to find this online with the magazine I subscribe to - YAY!! And to the negative nancy, believe me, butter is much better than vegetable shortening as well as the preservatives that are put into the store bought variety; and the fake sugar called corn syrup that is in the store bought kind will surely kill you. Anything in moderation is good and a couple of these as a treat once a week is alright!
by Justin2907,
2/15/2013This recipe is excellent and the taste is out of this world good. I formed the log and stuck it in the fridge, re-rolling it only twice and let it sit overnight to firm up.I found it easy to cut without any problems. My yield was 20 cookie sandwiches. I would probably double the filling next time I make it.
by Helgarde,
3/3/2012These tasted great. For a less sweet filling, you can use half butter and half cream cheese and reduce the sugar slightly.
Mia--if you're upset by the butter in the filling, think about what real Oreos use: it used to be hydrogenated vegetable oil--otherwise known as Crisco. Which would you rather eat, really?
by cpm323,
2/12/2012I just finished making these fabulous cookies. They have just the right salt to sweet taste and the cookie is perfectly tender and crisp. I used a one and a half inch round cutter to make the cookies more "oreo" sized and made 40 cookies.
by Czarena,
1/17/2012AB FAB!!! These cookies totally rock. My 5-year-old helped and they will be gracing her lunchbag here and there.
As my daughter is lactose intollerant, I substituted Earth Balance buttery sticks for the butter, egg replacer for the egg (sharing with a vegan friend), and soy milk for the milk in the frosting. They turned out SO GREAT!!! I will be making another full batch (we only made a 1/2 batch this time to try them out, and we did roll them smaller) for our Super Bowl party...I can only imagine how fast these babies will fly off the plate!
by JekU,
1/2/2012These cookies were great! I followed the actual directions at first, but had a hard time maintaing the rounded shape of the dough log. So I opted to roll them out and cut with 2 3/4" round cookie cutter. I was able to make 2 dozens oreo cookies that's so tasty and unique I gave them out for christmas! Everybody raved about it. The butter filling is heavenly. I placed it in an icing bag with a rounded tip and piped a small amount in the middle of one cookie, then used the other half to distribute it. No need to put a lot if you're feeling a little guilty. This recipe's a keeper.
by hanseata,
10/31/2011Made them as treat for Halloween. They turned out very nice. Working with the dough is a bit of a pain, though. I religiously rolled the log every 15 minutes while cooling, but the log was more oval than round, and very brittle to cut, even with my sharpest knife. But fortunately all the cracks and patched holes vanished during the baking. I like the great chocolate flavor of the cookies, the filling is a bit too sweet for my taste, but certainly right for the kids.
by Gabrie,
7/26/2011I only made the cookies (not the filling) as I was using them to make white chocolate coated cookies but they turned out great. I also rolled mine out and cut them into different shapes and the type of dough was absolutely perfect for cutting and rolling (I did it after letting the dough rest at room temp. for an hour and then chilled them before baking). Incidentally, I weighed my cocoa and it was exactly 3/4 cup.
by JPSavoringToday,
4/2/2011I made these yesterday for my daughter, but I rolled them out and used a 1 1/2" cookie cutter so they were closer in size to Oreos, which worked great and I ended up with about 50+ cookies. Great flavor in the cookie part, great recipe.
I did have one thing I wanted to mention: When I weighed my cocoa, 90 grams was close to 1 1/4 cup, not 3/4 cup.
by MissEpicurious,
2/20/2011really good interpretation of oreo cookies! I did not have to bake mine for 20 min, in fact they were done in about 14, so I would start double checking them at 12 min. For the person complaining about the butter in the filling; it's a cookie, of course it has butter in it. Find healthy specific recipes if you're concerned and don't be a negative-nancy.
by audrey629,
1/27/2011These were really tasty. The cookie had a very nice flavor and texture.
by imamma,
1/26/2011Must agree with the others. Your personal preference for fat content has nothing to do with rating a recipe. Unless that is, they are making such a claim, which is not the case here.......
These are a fun remake. Have you tried black cocoa? That will really give you the black color, not to mention the adult chocolate flavor. Good recipe.
by rude16,
1/26/2011@Mia 1...yes Mia, put a stick of butter between the two cookies...learn to read the recipie before commenting, it makes you seem inexperienced....to everyone else, made the cookies yesterday and they are delicious!!
by sread,
1/26/2011I made these yesterday. Very tasty, but I ran into a problem with the filling. I ran out of real butter and had to make the filling with one of the "healthy" margarines. The filling is way too runny. I had to refrigerate it in order to fill the cookies and then had to refrigerate the "oreos". So, don't substitute margarine. BTW, the cookie part tastes very similar to the original and the filling is much tastier than the original.
by jgdanby,
1/25/2011Mia1, pay attention here. These are Oreo replicas, after all. For 16 cookies, you'd have 1 1/2 teaspoons of butter in the filling of each cookie. Your one star because you think these are overly-fatty is unwarranted. All it matters is if the recipe works and the product presents well and tastes good.
by Mia1,
1/25/2011A stick of butter as the filling? Really?
by getsmart,
1/25/2011My son and his friends loved these cookies!!!!
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I have a Logitech USB MediaPlay Cordless Mouse, and whenever i use it, it stutters or the accleration is weird. It is very hard to click on anything. I've heard that Microsoft Mouses fair better. Is there true?
Is there a fix for the Logitech problem on Leopard 10.5.5., I have a leopard and vista dual boot on a quad core.
Thx in advance

subset: commoncrawl


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Beauty >Fusion Spa
481 8th Avenue, Suite 740, New York, NY | Directions 1000140.752579 -73.993182
Mon-Tue 10am-930pm
Wed 10am-8pm
Thurs 10am - 830pm
Fri 9:30am-7pm
Sat 9am-6pm
Sun 11am - 7pm
Neighborhoods: Midtown, Garment District
Great, great experience – My face has never felt so clean! I have only had about 5 facials in my entire life and had never felt they'd done much for me other than some gentle cleansing and bit of exfoliation, but seeing what a difference its made in my skin, I will definitely be going back to Tiffany for more regular treatments.
Fabulous facials – I have been a client of Tiffany's for many years and can't rate her highly enough. I struggled with adult breakouts throughout my later 20's and into my 30's, but Tiffany's thorough facials and recommended skin care regime have helped me get my sensitive but breakout prone skin in great shape. I've been asked by friends who know about my skin struggles what I've had done this past several years, and I let them know that I owe it all to Tiffany. It's all about the personalized customer service, at a great cost for the value.
Very good facial – Tiffany is very good and thorough. Fusion Spa isn't a fancy place but if you are looking for a good facial at a good price, go here.
The best facial in town! – I have been going to see Tiffany now for over eight years and would never see anyone else at this point. The level of service is amazing and I always leave feeling like a million bucks!
Great Facial – I had a great facial experience with Lisa! My skin is looking a lot better already, and I will definitely be scheduling my next appointment very soon! Highly recommend.
Best Clinical Facial – I have gone to see Lisa twice for a facial and decided immediately after the first time that I would be back on a monthly basis (at least). I have had many clinical facials in the past and Lisa's work takes the cake. My skin is clearing up thanks to her work and advice regarding the right and wrong facial products to use. These aren't your typical mini-massage/steam/mask facial you can get anywhere. The facials at Fusion Spa are customized to what your needs. I was pleasantly surprised by how thorough Lisa was in the extractions and by the fact that my skin was not red afterward, like it has been at other spas. I highly recommend this spa. The price is reasonable too, especially for the high quality of service you receive.
My face is in good hands – As a guy, I was a little apprehensive about going a "spa" for a "facial". The whole idea just seemed too girly for me and the treatments can be pricey. But my skin was in need of professional help. I did some research and found Fusion Spa. I checked out the website and booked a consultation. I really liked the warm, neutral, super clean space. It didn't feel like Barbie's Dreamhouse or smell like flowers. The consultation was very informative and there was no pressure to purchase products or services. The staff is extremely polite and professional and seemed genuinely interested in actually helping me get my skin in order. I asked Tiffany to recommend some products. I made a purchase and I booked an appointment. After a couple of weeks I noticed a big difference in my skin. Other people started to notice as well. Today was the "big day" that I had a few treatments done. I expected the appointment to be really clinical, scrub, wash, scrap, wash whatever. It was anything but that. I got the skin care treatments I expected, but the techniques used at fusion rejuvenated my skin AND my mind. I left feeling relaxed and focused with skin that feels and looks brand spanking new! It freakin rocked!! I already booked my next appointment.
great facial!! – It was one of the best facials I've ever had. With a personalized feel to the way they deal with their clientele and the place so clean and cozy. The products are amazing and I highly recommend it.
A-M-A-Z-I-N-G! – I've been to many salons facials for facials and have never been truly satisfied with the results:nothing to rave home about. After reading all the reviews I decided to give Fusion a try but unfortunately at that time Tiffany was no longer taking clients for awhile: she was booked up till eternity :)!
I waited awhile and checked back to see that she was now taking clients and had also another person working with her. Needless to say I got a Sunday appointment with the lovely Lisa in February before traveling abroad. She was very informative, outgoing and made sure that I was comfortable:not hard to do being that it smelled wonderful there and felt very calm and relaxing!
She went step by step explaining what she was doing and the products that she was using on my extremely sensitive combination skin. This was the 1st time that I've ever experienced a painfree facial with extractions not to mention no redness or irritation whatsoever!!
My skin was soft,smooth,supple & relaxed with a natural glow (no oily shine here). My skin felt so alive and the compliments I were getting after leaving surprised me since I had no makeup on. There was no pushing to buy products at all and I was given some wonderful samples to boot.
I was so impressed w/Lisa and the products which she used (Cosmedix & Dermalogica) that I bought them on the spot. A bit impulsive but well worth it and they work :)!!
For the quality & personalization of service that you receive here you would most definitely expect super high prices but they are very reasonable. Also a note for those with ethnic skin:Come Here! Being that I am multi-ethnic I am always overly concerned about what products to use on my skin and all my needs are addressed here.
I look forward to another appointment w/Lisa or Tiffany very soon to get some treatments!! Gotta love FUSION SPA, you can't go wrong!!
Best Facial Experience! – I had a facial with Lisa and I loved it! She worked thoroughly and was very careful on extracting my blackheads.I had other facials before that left my face red, but this one was so good she didn't hurt my skin and instead left my face glowing!
I have to add that I really liked the way this spa works, one on one sessions, very personalized. I highly recommend it and look forward for my next appointment.
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Connecting Clients with Communities: We celebrate everything that makes San Diego so unique and relish the opportunity to connect clients with the very best this magnificently diverse county has to offer.
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DULUTH, Minn. — UNO's penalty kill continued to short-circuit and the Mavericks' chance at home ice for the first round of the WCHA playoffs went up in smoke Saturday night.
Minnesota-Duluth went 4 for 4 on the power play through nearly two periods to build a 4-0 lead and scored five power-play goals in all in a 6-0 victory that sends the Mavs on the road for the first round of the playoffs.
The Bulldogs went 5 for 8 on the power play Saturday and 7 for 12 with the man advantage for the weekend while sweeping the series.
UNO was shut out for the first time all season and suffered its worst loss since a 7-0 setback at Denver on Jan. 1, 2010.
For the second straight year, UNO lost its final four regular-season games to miss out on home ice, which goes to the top six finishers in the WCHA. This time, though, the final three losses were stunning — with 17 goals allowed, including nine on 19 power-play chances.
The 16th-ranked Mavs (18-16-2, 14-12-2 WCHA), who have lost seven of their last nine, will finish in seventh place and will play a first-round playoff series next weekend at the sixth seed.
The likely opponent, according to the WCHA's published tiebreaker scenarios, is 10th-ranked Minnesota State-Mankato — assuming Denver wins against last-place Alaska-Anchorage on Sunday afternoon. If the Pioneers tie or suffer an upset loss, then they would host UNO in the first round.
UNO split a home series with Minnesota State in December, and went 0-1-1 at Denver in early January.
Back then, the Mavs were on a pretty good roll.
But over the last five games, UNO's opponents are a remarkable 13 for 25 (52 percent) on the power play. They are 14 for 28 (50 percent) over the last seven games and 21 of 64 (32.8 percent) over the last 17 games dating to Dec. 30.
Overall, UNO has given up 26 goals in its last five games, though one of those games was a win.
Joe Basaraba scored two goals to complete a three-goal weekend, Austin Farley had a goal and an assist to complete a six-point (two goals, four assists) weekend and Caleb Herbert had three assists for the Bulldogs (14-17-5, 10-13-5), who finished in ninth place.
Herbert had five assists for the weekend, while Tony Cameranesi had two assists each night.
Aaron Crandall made 32 saves for the shutout, his fourth win of the season.
Mike Seidel, who had a five-point weekend, found Farley alone at the back door for the game's first goal at 9:56 of the first period.
Another power play, another goal for Minnesota-Duluth just more than six minutes later, as Cal Decowski got his third goal of the season on assists from Cameranesi and Herbert at 16:11.
Trailing 2-0, UNO twice hit posts in the opening five minutes of the second period — first by Josh Archibald and then by Jaycob Megna — before Minnesota-Duluth made it 3 for 3 with the man advantage.
Basaraba delivered a strong backhander to the far post for a 3-0 lead at 7:53 of the second period.
With UNO already trying to kill off another penalty, defenseman Andrej Sustr was sent off with a game misconduct for a check from behind, putting the Bulldogs on a 5-on-3 and setting up five more minutes of power play time.
Andy Welinski scored on a one-timer just eight seconds later.
Minnesota-Duluth would have opened the third period with four minutes more of power play time remaining — and the ability to score an unlimited number of goals since it was for a major penalty — but Cameranesi was hit with a roughing penalty at the end of the second period. That was UNO's first successful penalty kill.
UNO's Dominic Zombo got a game misconduct and a five-minute major for checking from behind early in the third period, and Basaraba scored his second goal during the ensuing power play.
Seidel scored his third goal of the series, this one at even strength, with 5:41 left.


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MERCED — At the year's halfway point, businesses appear to be looking at Merced with greater optimism.
"The businesses that were looking to come into Merced in the past that put their projects on hold, they're coming back," said Frank Quintero, Merced's economic development director.
Quintero said it's too early in the process to give company names, but he's meeting with firms who want to evaluate the city. Besides the businesses that are giving the city another look, he said other companies have been in contact with him.
He said he agrees with a study by Stockton's University of the Pacific that predicts slow and steady growth in Merced. The study predicts more than 2 percent job growth in the area through 2016.
"We will continue to see activity grow in Merced," Quintero said, particularly downtown.
Quintero said the area is experiencing a boost from some entrepreneurs who have been drawn to the city's entertainment hub, and the new businesses on Main Street are a welcome sight to some downtown patrons.
"I hope that it keeps progressing in that direction," Melissa Beckwith, 32, said.
The Merced-area nanny said she spends many hours in downtown at Playhouse Merced.
"It's a good area historically; the buildings are really great," Beckwith said. "It would be nice to keep the focus down here."
A new bar and eatery downtown are the latest signs of an uptick in business activity, as is a boat dealer at the edge of Main Street.
A beer and wine bar, 17th Street Public House, flung open its doors for the first time Thursday. The business at 315 W. Main St., which specializes in craft beers and wine, is owned by the same partners who run The Partisan.
R.C. Essig, 33, said the bar has a laid-back atmosphere, and sports 18 beers on tap and 29 in the bottle.
"This place is all about networking, and being able to drink and talk to people," Essig said, "and not really have to have a DJ or whatever event."
Essig said the craft beers take advantage of a niche market, so it can be successful while not hurting other bars in the area. "I never step on toes," he said.
Another upstart, At The Pier, moved into downtown on June 5. Kris Bruns, who opened the business with wife Sherry, said the eatery at 439 W. Main St. offers hot dogs, clam chowder and funnel cakes, among other foods you might find at the beach.
"I do a lot of motorcycle riding up and down the coast," the 45-year-old said. "I thought, 'It's the kind of foods I like, so (I'll) try this.' "
One sign of an improving economy to Todd Gaughn is the increase in boat manufacturing and sales.
The 34-year-old opened Central Valley Power Sports, 1775 V St., on June 29. "Jobs are on the rise, boat sales are on the rise, there's a region that has existing sales and customers," Gaughn said, referring to the Merced area. "It's an opportunity."
The dealer sells boats made by Centurion, Supreme and Polaris. Gaughn said he specializes in inboard motorboats, which are primarily used for wakeboarding.
Not every part of Merced is seeing growth, though.
Quintero said south Merced has not seen much change. Plans for a neighborhood shopping center near Childs Avenue and Canal Street hit some snags.
He said the state's decision to squash redevelopment agencies in 2012, and phase out the Enterprise Zone Program this year could slow growth in south Merced.
"That makes trying to draw an investor or a retailer into an underserved area very difficult," he said.
Retail stores have proven cautious in the first part of the year, Quintero said. "They're really studying the numbers and making sure our market can support whatever their business model is," he said.
The existing retail stores should continue to do well, Quintero said, as places like the Merced Mall and Merced Market Place continue to draw from the entire region.
Reporter Thaddeus Miller can be reached at (209) 385-2453 or firstname.lastname@example.com.


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Health Reform
the latest
- The Affordable Care Act's Impact on Medicaid Eligibility, Enrollment, and Benefits for People with Disabilities
- Those Long Lines To Enroll In The ACA
- The Uninsured at the Starting Line in Missouri: Missouri findings from the 2013 Kaiser Survey of Low-Income Americans and the ACA
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Where does your state stand?Compare Data
Consumer Resources on Health Reform
Animated video, subsidy calculator, frequently asked questions about health reform, and "Obamacare and You" fact sheets help explain how the ACA affects you.See Consumer Resources
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current issues
The ACA's health insurance marketplaces are intended to promote price competition in the individual and small group markets through greater transparency. The following resources look at how the ACA has impacted market competition and how much Americans pay for coverage.
Dec. 2013 | Policy Insights
The Numbers Behind "Young Invincibles" and the ACA
In the latest post in the Policy Insights series, Larry Levitt, Gary Claxton and Anthony Damico discuss why enrolling young adults in the new health insurance marketplaces is important, but not as important as conventional wisdom suggests.View All Health Reform Perspectives


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Rydges Auckland Hotel
Rydges Auckland Hotel has set a new standard in hotel accommodation, style, service and contemporary elegance.
The city's latest hotel mixes elements of London sophistication, Sydney cool and New York style, with the bonus warmth of world class Kiwi hospitality, making this one of the finest Auckland CBD hotels.
Offering accommodation in close proximity to the centre of the city, Rydges is ideal for both business and leisure. It is a short stroll to the Viaduct Harbour, Auckland's stunning waterfront with an array of restaurants and bars. There's an abundance of shopping right on our doorstep. High Street and the Chancery are home to original fashion designers, artists, jewellers and café owners.
Standing proudly above the city on Hobson Street, Rydges Auckland Hotel presents the new Hobson Tower with stunning Auckland accommodation, complete with 88 beautiful guest rooms to form a 267-room urban oasis in the heart of Auckland.
Our friendly and attentive team are on hand to assist you in exploring Auckland and beyond. We are dedicated to ensure your expectations are exceeded in a fresh, friendly and contemporary hotel environment.
Here's our factsheet for more information Rydges Auckland.
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Yeah, it worked! Your marketing message, whether it's an ad, a direct mail piece, a well-timed phone call or any other creative marketing tool, creates enough interest to convert a suspect into a prospect.
They say, "Let's meet!" Phew. Step one is successful!
You meet. The chemistry is cooking. You bond. They love you, and assure you a decision is on its way. Cool! Looks like you're victorious in step two.
And now... you wait.
Paint is drying.
And wait.
Grass is growing.
And wait.
Nada. Bupkus. Zip. Nuthin' is happenin'.
Sound familiar? Ouch!
Clients often share with me similar frustrations when their prospects don't return their phone calls or respond to their e-mails, faxes and letters. They are forever stuck in prospect purgatory, the maddening and inhospitable land of no decision! So, when clients request my counsel to combat this dilemma, I'll often suggest they call their "psychiatrist."
Huh? Well, first I should mention that I've been very fortunate. It's unusual for a prospect not to respond to my voice-mails or e-mails. That's likely because I'm marketing to and dealing with prospects who are referrals. (We'll revisit the topic of referrals in future columns.) Or, they've "found me" via an article, book, speaking engagement, etc. I don't attempt to woo frigid prospects in cold calls. I've never been a big fan of chilly receptions.
However, on that rare occasion when my polite and persistent attempts to yak with a prospect are unsuccessful, I seek medical help. My theory: If "traditional" attempts at communication ain't working, it's okay to go crazy! The following is verbatim language, I've used with prospects who are still suspects:
I haven't slept in days!
Am going without food and water!
Am waiting near the phone!
Am hovering over the fax machine!
Am checking e-mails every 10 minutes!
Yet my clients who you wanted to contact, and I still haven't heard from you.
My psychiatrist said, "Stop worrying!" He said you'll contact all of us soon about how I can help you and your team like we continue to help others maximize results and profitability.
Like the CEO who e-mailed me...
(will feature excerpts from the e-mail)
Or the president and vice president who wrote...
(will feature excerpts from the letters)
We're all waiting to hear from you!
Please let me know what our gameplan is, before I lose even more sleep and weight!
Okay, is the preceding crazy? Maybe. But who cares. It works!
Folks will then call or e-mail me and apologize for the delay. They even thank me for getting their attention in a fun and unique way! They'll also say they want to be sure I'm eating and sleeping again!
The purpose of this "loony language" is simple. To generate: Interest. Dialogue. Opportunity. Results. Outcomes. Satisfied clients. Remember, when the norm, standard or status quo ain't producing the results you want, go nuts! Do the unexpected! Bust out of the box! It delivers. Big time!
Profit points:
1. Marketing and business-growth are about results, not logic.
2. Capture attention with uniqueness and creativity.
3. Experiment. Play. Push the possibilities. Far better to be an innovative success than a by-the-book failure.
4. Focus on action that drives a decision. Convert silence into a "Yes," "No" or "Not yet."
5. Acknowledge that the traditional, long-established and time-honored ways of doing stuff might need to be abandoned.
Jeff Blackman is a speaker, author, success coach, broadcaster and lawyer who lives part-time on Marco Island. His clients call him a "business-growth specialist." Send an e-mail to email@example.com or go to jeffblackman.com to subscribe to his free e-letter.


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Safety and Efficacy of Listeria and GVAX in Pancreatic Cancer
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This clinical trial will evaluate the safety, immune response and overall survival of the sequential administration of two cancer vaccines, GVAX Pancreas Vaccine and CRS-207. GVAX vaccines are composed of cancer cells that have been genetically-modified to secrete granulocyte-macrophage colony-stimulating factor (GM-CSF) to stimulate the immune system and that have been irradiated to prevent further cell division. GVAX Pancreas is administered with cyclophosphamide, which has been shown to increase effectiveness of GVAX by inhibiting T regulatory cells. CRS-207 is a weakened (attenuated) form of Listeria monocytogenes that has been genetically modified to reduce its capacity to cause disease, while maintaining its ability to stimulate potent innate and adaptive immunity. CRS-207 has been engineered to elicit an immune response against the tumor-associated antigen mesothelin, which has been shown to be present at higher levels on certain tumor cells than on normal cells.
Pancreatic Cancer
Drug: GVAX Pancreas, Cyclophosphamide and CRS-207
Drug: GVAX Pancreas and Cyclophosphamide
Phase 2
|Study Type:
|Study Design:
|Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:
|A Phase 2, Randomized, Multicenter, Open-Label Study of the Efficacy and Immune Response of the Sequential Administration of GVAX Pancreas Vaccine Alone or Followed by CRS-207 in Adults With Metastatic Pancreatic Adenocarcinoma
- To compare overall survival in subjects receiving test treatments [ Time Frame: Up to five years ] [ Designated as safety issue: No ]Patients will be followed at regular intervals to assess survival
- To assess safety of the cyclophosphamide, GVAX Pancreas vaccine, and CRS-207 treatment regimen [ Time Frame: About 2 years ] [ Designated as safety issue: Yes ]Patients will be monitored for adverse events throughout the course of the study
- To assess the immune response [ Time Frame: About three years ] [ Designated as safety issue: No ]Patient samples will be evaluated for vaccine-induced Listeria- and mesothelin-specific immune responses
|Estimated Enrollment:
|Study Start Date:
|September 2011
|Estimated Study Completion Date:
|October 2014
|Estimated Primary Completion Date:
|July 2014 (Final data collection date for primary outcome measure)
|Assigned Interventions
Experimental: Vaccine Arm A
60 patients total.
Weeks 1 and 4:
Cyclophosphamide (Day 1) GVAX pancreas vaccine (Day 2)
Weeks 7, 10, 13, and 16:
CRS-207 (Day 1)
Drug: GVAX Pancreas, Cyclophosphamide and CRS-207
Cyclophosphamide (200 mg/m2), GVAX Pancreas vaccine (5 × 10e8 cells), CRS-207 (1 × 10e9 CFU)
Other Name: Cytoxan, GM-CSF, Listeria
Experimental: Vaccine Arm B
30 patients total.
Weeks 1, 4, 7, 10, 13, and 16:
Cyclophosphamide (Day 1) GVAX pancreas vaccine (Day 2)
Drug: GVAX Pancreas and Cyclophosphamide
Cyclophosphamide (200 mg/m2), GVAX pancreas vaccine (5 × 10e8 cells)
Other Name: Cytoxan, GM-CSF
Detailed Description:
This is a Phase 2, randomized, multicenter, open-label study of cyclophosphamide and GVAX pancreas vaccine followed by CRS-207 in adults with metastatic pancreatic adenocarcinoma who have received or refused at least one prior chemotherapy treatment.
Eligible subjects will be randomized in a 2:1 ratio to receive either two doses of cyclophosphamide and GVAX pancreas vaccine and up to 4 doses of CRS-207 at 1 × 10e9 CFU (Treatment Arm A) or up to six doses of cyclophosphamide and GVAX pancreas vaccine (Treatment Arm B). Study assessments include blood draws for safety and immune response monitoring and CT scans for tumor response evaluations.
After completion of treatment, subjects will continue to be followed by phone and optional clinic visits for the duration of the study. At the investigator's discretion, subjects may receive additional cycles of the assigned treatment regimen if they are clinically stable and meet dosing eligibility. At the conclusion of the study, all remaining subjects will be offered enrollment in a long-term follow-up study.
|Ages Eligible for Study:
|18 Years and older
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Inclusion Criteria:
- Have histologically proven malignant adenocarcinoma of the pancreas; measurable disease is not required. (Subjects with mixed histology will be included if the predominant component is adenocarcinoma. Subjects must have metastatic disease.)
- Have received or refused at least one chemotherapy regimen
- Be at least 18 years of age
- Have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
- Have an anticipated life expectancy of greater than 12 weeks
- For women and men of childbearing potential, a medically acceptable method of highly effective contraception (oral hormonal contraceptive, condom plus spermicide, or hormone implants) must be used throughout the study period and for 28 days after their final vaccine administration. (A barrier method of contraception must be employed by all subjects [male and female], regardless of other methods.)
- Be willing and able to give written informed consent, and be able to comply with all study procedures
- Have adequate organ function as defined by specified laboratory values
Exclusion Criteria:
- Currently have or have history of certain study-specified heart, liver, kidney, lung, neurological, immune or other medical conditions
- Have a known history or evidence of brain metastases
- Have any evidence of hepatic cirrhosis or clinical or radiographic ascites
- Have clinically significant and/or malignant pleural effusion
- Known or suspected hypersensitivity to any component of GVAX Pancreas vaccine or CRS-207, or known allergy to both penicillin and sulfa
- Received an investigational product within 28 days of study treatment or planned to receive within 28 days after vaccine administration
- Used any systemic steroids within 28 days of study treatment
- Use more than 3 g/d of acetaminophen
- An artificial (prosthetic) joint or other artificial implant or device that cannot be easily removed (with some exceptions for dental and breast implants and biliary stents and mediports)
- Major surgery or significant traumatic injury (or unhealed surgical wounds) occurring within 28 days prior to receiving study drug, or planned surgery requiring general anesthesia
- Infection with HIV or hepatitis B or C at screening
- Any immunodeficiency disease or immunocompromised state or active autoimmune disease or history of autoimmune disease requiring systemic steroids or other immunosuppressive treatment
- Be a woman who is pregnant or breastfeeding
- Unable to avoid close contact with another individual known to be at high risk of listeriosis (e.g., newborn infant, pregnant woman, HIV-positive individual) during the course of CRS-207 treatment until completion of antibiotic regimen
- Conditions, including alcohol or drug dependence, intercurrent illness, or lack of sufficient peripheral venous access, that would affect the patient's ability to comply with study visits and procedures
|United States, Florida
|H. Lee Moffitt Cancer Center
|Tampa, Florida, United States, 33612
|United States, Maryland
|Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Hospital
|Baltimore, Maryland, United States, 21231
|National Cancer Institute
|Bethesda, Maryland, United States, 20892
|United States, Missouri
|Washington University School of Medicine
|St. Louis, Missouri, United States, 63110
|United States, New York
|Herbert Irving Comprehensive Cancer Center of Columbia University
|New York, New York, United States, 10032
|NYU Langone Medical Center
|New York City, New York, United States, 10016
|United States, North Carolina
|Duke University Medical Center
|Durham, North Carolina, United States, 27710
|United States, Oregon
|Providence Portland Medical Center
|Portland, Oregon, United States, 97213
|United States, Pennsylvania
|University of Pittsburgh Medical Center
|Pittsburgh, Pennsylvania, United States, 15213
|United States, Washington
|Virginia Mason Medical Center
|Seattle, Washington, United States, 98101
|Principal Investigator:
|Dung T Le, MD
|Johns Hopkins University
Additional Information:
|Responsible Party:
|Aduro BioTech, Inc.
|ClinicalTrials.gov Identifier:
|NCT01417000 History of Changes
|Obsolete Identifiers:
|Other Study ID Numbers:
|Study First Received:
|August 10, 2011
|Last Updated:
|January 10, 2014
|Health Authority:
|United States: Food and Drug Administration
Keywords provided by Aduro BioTech, Inc.:
Cancer vaccine
Listeria monocytogenes
Listeria-based vaccines
T regulatory cells
Heterologous Prime-Boost
Pancreatic cancer
Additional relevant MeSH terms:
Pancreatic Neoplasms
Digestive System Neoplasms
Neoplasms by Site
Endocrine Gland Neoplasms
Digestive System Diseases
Pancreatic Diseases
Endocrine System Diseases
Immunosuppressive Agents
Immunologic Factors
Physiological Effects of Drugs
Pharmacologic Actions
Antirheumatic Agents
Therapeutic Uses
Antineoplastic Agents, Alkylating
Alkylating Agents
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Myeloablative Agonists
Gastrointestinal Agents
ClinicalTrials.gov processed this record on April 22, 2014


text:
Availability: Holiday Inn Long Beach Airport Hotel and Conference Center
Please enter your travel dates.
Standard Non-Smoking - Advance Purchase
- 1 bed
Standard Two Double Beds - Advance Purchase Non Refundable
- 2 double
Double Beds Standard Westwing Building - Advance Purchase Non Refundable
- 2 double
Executive One King Bed - Advance Purchase Non Refundable
- 1 king
Long Beach hotel with an outdoor pool
Situated near the airport, in Long Beach, this hotel is close to Recreation Park Golf Course, California State University Long Beach, and Earl Burns Miller Japanese Garden. Local attractions also include Walter Pyramid and VA Long Beach Medical Center.
Hotel Features
In addition to a restaurant, Holiday Inn Long Beach Airport Hotel and Conference Center features an outdoor pool. Other amenities include a bar/lounge and a conference center.
Room Amenities
Flat-screen televisions come with premium satellite channels. Guestrooms also feature complimentary wireless Internet access, refrigerators, and air conditioning.Information missing or incorrect? Tell us!
Holiday Inn Long Beach Airport Hotel and Conference Center Amenities
- General
Holiday Inn Long Beach Airport Hotel and Conference Center features an outdoor pool and a fitness center. The hotel offers a restaurant. A bar/lounge is on site where guests can unwind with a drink. A computer station is located on site and high-speed wireless Internet access is complimentary.
This 3-star property offers access to a 24-hour business center, audiovisual equipment, and a meeting/conference room. Event facilities measuring 8000 square feet (720 square meters) include a conference center, a ballroom, and banquet facilities. This business-friendly hotel also offers multilingual staff, concierge services, and complimentary newspapers in the lobby. An area shuttle within 3 mi and a roundtrip airport shuttle (available on request) are complimentary for guests. Complimentary self parking is available on site.
Holiday Inn Long Beach Airport Hotel and Conference Center is a smoke-free property.
- 24-hour front desk
- Air-conditioned public areas
- Airport transportation (complimentary)
- ATM/banking
- Audiovisual equipment
- Ballroom(s)
- Banquet facilities
- Bar/lounge
- Breakfast available (surcharge)
- Business services
- Complimentary newspapers in lobby
- Event catering
- Concierge services
- Express check-out
- Dry cleaning/laundry service
- Elevator/lift
- Shopping center shuttle (complimentary)
- Fitness facilities
- Designated smoking areas
- Designated smoking areas (fines apply)
- Computer station
- Express check-in
- Laundry facilities
- One meeting/conference room
- Multilingual staff
- Number of floors - 13
- Total number of rooms - 222
- Free parking
- Free guest parking during stay
- Free self parking
- Parking nearby (surcharge)
- Parking nearby
- Porter/bellhop
- Luggage storage
- Restaurant
- Room service (limited hours)
- Safe-deposit box at front desk
- Meeting facilities size (meters) - 720
- 24-hour business center
- Meeting facilities size (feet) - 8000
- Free outdoor parking
- Long-term parking (surcharge)
- Free RV, bus, truck parking
- Offsite parking reservations required
- Conference center
- Smoke-free property
- Smoke-free property (fines apply)
- Swimming pool - outdoor
- Free Wi-Fi
- Area shuttle (complimentary)
- Internet
Available in all rooms: Free Wi-Fi
Available in some public areas: Free Wi-Fi
- Parking
Free parking, Long-term parking (surcharge), Free guest parking during stay, Free outdoor parking, Free self parking, Free RV, bus, truck parking, Parking nearby, Parking nearby (surcharge), Offsite parking reservations required
- Room Amenities
- Flat-panel TV
- Free Wi-Fi
- Premium TV channels
- Complimentary toiletries
- Refrigerator
- Phone
- Air conditioning
- Satellite TV service
- Rollaway/extra beds available
- Coffee/tea maker
- Complimentary newspaper
- Desk
- Hair dryer
- Daily housekeeping
- Iron/ironing board
- In-room safe
- Pay movies
- Private bathroom
- Shower/tub combination
- Pillow menu
- Connecting / adjoining rooms available
- Cribs/infant beds (complimentary)
- Dining
Holiday Inn Long Beach Airport Hotel and Conference Center has a restaurant on site.
Room service (during limited hours) is available.
- Recreation
Recreational amenities at the hotel include an outdoor pool and a fitness facility.
- Accessibility
To make requests for specific accessibility needs, complete the "Special or Accessibility Requests" section of "Trip Preferences" when you book your hotel.
- Accessible path of travel
- Accessible bathroom
- Roll-in shower
- Accessible parking
- In-room accessibility
- Accessibility equipment for the deaf
- Braille or raised signage
Holiday Inn Long Beach Airport Hotel and Conference Center Policies & Fees
- Check-in
Check-in time starts at 3 PM
- Check-out
Check-out time is noon
- Payment types
Accepted at this hotel: American Express, Carte Blanche, Diners Club, Discover, JCB International, MasterCard, Visa
- General
Extra-person charges may apply and vary depending on hotel policy.
Government-issued photo identification and a credit card or cash deposit are required at check-in for incidental charges.
Special requests are subject to availability upon check-in and may incur additional charges. Special requests cannot be guaranteed.
- Additional Details
This property offers transfers from the airport. Guests must contact the property with arrival details on arrival, using the contact information on the booking confirmation. The property has connecting/adjoining rooms, which are subject to availability and can be requested by contacting the property using the number on the booking confirmation.


text:
Rick Perry's Bizarro World tax plan
Win McNamee/Getty Images
GOP Presidential Candidate Rick Perry
I honestly didn't think anyone could — or would — come up with a worse plan for U.S. tax reform than Herman Cain did with his 999 proposal. But Texas Gov. Rick Perry just released his "Cut, Balance and Grow" plan, which is also being referred to as the "20-20" plan, echoing Cain's 999. The difference is that Perry replaces Cain's 9 percent flat income and corporate taxes with a 20 percent flat tax for both. But there's more! And just in time for Halloween, it's...terrifying!
I'd like to call it stupid, but ridiculously stupid would be better.
The plan has four key pieces:
- Americans will be able to choose between the current tax system and the 20-percent flat tax.
- Corporations will see their tax rate cut from an average of 35 percent under the current system to a flat 20 percent with Perry's plan.
- Federal spending would be capped at 18 percent of GDP, which Perry argues is the average since 1960. This will, he insists, balance the budget by 2020.
- Workers would be able to opt out of Social Security.


text:
You can also read manga online try the Jisatsu Circle manga!
You're reading Jisatsu Circle 6 online. You can try some of the related manga below or try some other manga from our manga list.
Users who read Jisatsu Circle also read Suki Dakedo!, Bokura ni Matsuwaru Etcetera, Wild Darling, Beast Master, Akiiro Bousou Biyori and Aishichattano.


text:
Congratulations to our Devereux Day School Staff!
Tuesday, June 26, 2012
By: Devereux Arizona
(Devereux Arizona)
The National Association of Special Education Teachers (NASET), would like to congratulate our DEVEREUX DAY SCHOOL on having met the standards to be selected as 2012-2013 NASET School of Excellence. This distinction has been bestowed upon only a few select qualified licensed private special education schools in the State of Arizona.
Selection as a NASET School of Excellence is the highest level of recognition a private special education school can achieve through our professional association. This honor is presented to private special education schools that meet rigorous professional criteria and have demonstrated truly exceptional dedication, commitment and achievement in the field of special education.
Human Resources | Privacy | HIPAA | CIPA | Disclaimer | Contact Us
The Devereux Foundation
(800) 345-1292


text:
He will never get past the primary, several stronger candidates have already dropped out.
Just a quick note to our many thousands of readers in the Lone Star State…
Please vote down Craig James. The former college football star at SMU — if you're looking for character flaws, look up his ties to the Pony Express — left his job as an ESPN analyst yesterday in order to run for a US Senate seat in Texas.
Yeah, 'cause if there's anyone ready to "fix" Washington, it's a guy who's become one of the most unpopular college football analysts on television. His take down of Texas Tech's Mike Leach — reportedly because the coach was a meanie to his son, Adam — still might cost ESPN millions in a lawsuit brought by Leach.
James says he was protecting his son. Most people in and around Lubbock will tell you they believe Leach, not James.
Asked about his political qualifications, here's what James told the AP:
"Washington is busted up, and I understand how the economy works because I have been concerned about continuing to provide jobs in this economy, not 10 years ago, not 15, not 20 years ago. I live in this economy, I get it. We need someone from what I call Real Street, this is what separates me."
Good to know James doesn't fit the ramble-at-the-mouth dumb jock stereotype. Also, if living in the economy is a qualification for becoming a Senator, then I, too, would like to toss my hat in the ring. Those folks get a darn fine retirement plan and great health benefits.
Forget politics, people. I could care less about his party affiliation (he's running as a Republican, by the way). As a nation, we send plenty of dimwits from both parties to DC every couple of years. It happens. But here's hoping Texans don't send this one.


text:
MMQB (cont.)
1. I think if you're looking for draft grades, you'll have to look somewhere else. Grading drafts after they happen is like grading students for the term on the first day of class, and I've been out of that business for a few years now.
2. I think Kellen Moore going undrafted after going 50-3 in college and putting up stupid numbers and being one-quarter of an inch shorter than Drew Brees and 1.5 inches taller than Russell Wilson is patently absurd. I hope he makes the Lions and wins a playoff game. Soon.
3. I think those at Radio City Music Hall in Manhattan who uproariously booed the 10-year-old child making the late-round Patriots' draft choice need to do some value-system adjustments with their lives.
4. I think when commissioner Roger Goodell issues his discipline against Saints players (almost certainly this week) for their purported involvement in the bounty scandal, he might be surprised at the intensity of the fight from the National Football League Players Association over the sanctions.
It's not just the fact that the union is trying to protect its members without the definitive proof it was seeking that the players promoted and pushed the bounty system. (Though Goodell, I'm told, feels secure in the knowledge that the players were more than just the bankers of the system.) The players will use as their bedrock point, I believe, that the system was imposed and pushed by defensive coordinator Gregg Williams, not some cadre of rogue defensive team leaders. This thing is not going away.
5. I think that reminds me of something Goodell said to me during one of my three or four substantive interviews for a Sports Illustrated profile on him. I forget the topic, but I made the point the union was going to fight hard on some issue or another. He looked at me with a humorless stare and said: "We've got good lawyers too."
6. I think the best NFL news of last week, aside from the Luck/RG3 savior stuff in two NFL cities, is that the Pro Bowl is on life support. It should be. There is no reason to play a game that no player really wants to play, and it shows every year, with the lack of effort making it a mockery. I'm making that assumption, really, based on highlights/lowlights and what I saw the year it was in Miami, because I don't watch the game. The NFL should know by now the game is unfixable.
7. I think Ross Tucker, my buddy at SiriusXM NFL Radio, had a great takeaway on the draft, on the inexact science of talent evaluation. "Boise had as many guys drafted as USC and Texas combined, even without Kellen Moore,'' Tucker observed.
8. I think I love what the Raiders did over the weekend -- independent of the draft. They announced they would donate 10 percent of all ticket sales between May 1 and June 30 to the Oakland Unified School District. That should help motivate all fans thinking of buying seats to do so in the next two months. It's a tremendous cause, for those who aren't familiar with the needy school district. And I applaud the Raiders for stepping up to the plate.
9. I think I like lists as much as the next football follower. But is there a defense for Green Bay fullback John Kuhn being 92nd on the NFL Network's list of the top 100 players in the NFL? After playing 29 percent of his team's snaps over the past three years? After not being in the top-20-rated fullbacks on the ProFootballFocus list of fullbacks for the 2011 season? It's absurd.
10. I think these are my non-football thoughts of the week:
a.Veep is the best new thing I've seen on TV since the rookie year of The Office.
b.The Office, by the way, has become unwatchable. Silly, ridiculous plots.
c. Tremendous baseball point by Keith Olbermann. The baseball aficionado pointed out Saturday that for Mickey Mantle's big-league debut in 1951 and for Bryce Harper's in 2012, Vin Scully was in the broadcast booth both times.
d. Harper looks like he'll be incredibly fun to watch over the years, as long as he does something about that haircut.
e. I'm no big hoops fan, but that Derrick Rose injury was incredibly sad and that Clippers comeback was utterly amazing.
f. I'd like to host a fireside chat with Eli Manning and Kevin Durant. Subject: How to play your best when the game is on the line. Durant's incredible.
g. I know this is redundant, but when the NHL playoffs are on, I cannot look away. Devils down three games to two, Game 6 goes to overtime in New Jersey and the Devils win 3-2. Game 7 goes to a second overtime in Florida and the Devils win 3-2. Thirty-two of 48 games in the first round of the playoffs were decided by a goal. The first five games of Phoenix-Chicago went to overtime. And Sunday in Philly, another overtime job in Game 1 of Devils-Flyers. Great sport.
h. How does Doc Emrick not get hoarse more often?
i. This can't have happened very often: Through five innings Saturday against Miami starter Anibel Sanchez, Arizona led 2-0 with its third and fourth batters striking out in all six at-bats.
j. Story of the Week, from the New York Times, on the brutish Ty Cobb, and some sick vengeance.
k. Bruce Springsteen at Jazz Fest in New Orleans Sunday, during the day. What a scene that must have been.
l. Coffeenerdness: JFK Airport, Delta terminal, Starbucks, 7 a.m. Friday. I am 18th in line. There's one barista making drinks and also getting the drip coffee orders and making the drip coffee when need be. There's one person at the register taking orders. There are four more employees on hand. One is on garbage detail. One is getting pastries and food. One is in the back, apparently straightening out the stock for the day. One is -- well, I'm not sure what she was doing, except the barista kept calling for her and she never appeared, though there was evidence of another employee in the back of the store, behind the door.
Six employees, painfully slow line, one making the espresso drinks and pouring the drip coffee that everyone is in line to get. Might there possibly be a better deployment of your employees, Seattle?
m. Beernerdness: Not a great beer selection at the Marlins new ballpark -- I saw four innings there the other night -- but I have to hand it to them: At several locations in the lower concourse was Presidente Beer, the tasty light pilsner from the Dominican Republic. Very good light, drinkable humid-weather beer.
n. The stadium itself reminded me of the Diamondbacks stadium in Phoenix, a spacious monster, with a huge center field and that bizarre structure in left-center that I guess is supposed to illustrate the diversity and art and wildlife of south Florida but just looks awful. It's a comfy place. The food is tremendous; I strongly recommend the steak soft tacos (not sure if that's what they're called) at the Miami Mex stand in the upper deck.
I loved the diversity -- major league baseball, and all sports really, need to attract fans of all color and nationality, and two Latino families sat on either side of me. I wonder how long the fans will come. A vast number of them the other night were there to be social and to see the big new spaceship in Little Havana, not to watch the game.


text:
Blender 2.70a release is out
The first of a new 2.7 series has been released! Work on UI improvements started, and a lot of features were added for Cycles render, motion tracking, animation, modeling, and so on.
Update: 2.70a has been released now.
Gooseberry Open Movie
Campaign will extend if we make it to 3000 supporters. Help us writing open source animation film making history!
Latest News
- Plans for 2014-2015Code Blog | December 22nd
- New Development InfrastructureCode Blog | November 29th
- Network News – November 2013Blender Network | November 19th
- (Re)defining BlenderCode Blog | October 23rd
- Introducing the Job BoardBlender Network | October 10th


text:
Friday, January 25, 2008
Up To Date
On a recent post I mentioned Uptodate as a great source for medical information. Most residents trained these days are raised on Uptodate. Currently a subscription costs $495 annually, tho you get to renew for $395. I would have trouble practicing medicine without it.
It started as a great source for primary care docs, but they are adding content constantly and is not endorsed by some specialty societies as well. The information is evidence-based where possible, and well sourced.
I turn to it often, for all those diagnoses or clinical questions that I only run across a few times a year. It's a great refresher. It has all but replaced my textbooks, which are outofdate by the time you get them. I continue to use my sports medicine book, and my derm books, but little else.
It's got some downsides. I don't like the patient handouts - they're written at too high a level for my liking. I don't always love the way that it separates information on conditions. It often has a separate article completely for diagnosis, treatment, etiology, etc. I don't find it useful for derm issues either - I still need to leaf through something and look at pictures often. There are more and more photos, but of course you need to know the condition you are looking up first, which is not always the position that I am in.
All in all, I am a better doctor for Uptodate. While I'm at it, Epocrates on my palm pilot is difficult to live without. For good measure, I also officially endorse Hershey's Nuggets Dark Chocolate with Almonds.
7 comments:
- Femail doc said...
Ouch, that is pricey. But that's also high praise, and textbooks are cumbersome, out-of-date, and the print has gotten way too small for these aging eyes to scan in a hurry. I think I'll give it a whirl.
Residents in my day hauled the Washington Manual around. Period. I'm lucky to stay in contact with my stethoscope, reading glasses, a pen, and an rx pad during office hours. My palm pilot is NEVER where I need it.
- January 26, 2008 at 10:37 AM
I LOOOOOOOVE UpToDate! I recently graduated from residency and moved from the States to New Zealand to practice for a year. I use it several times every day and it saves my butt over and over again (who remembers what urine test you order to rule out a carcinoid tumor? UpToDate knows! etc). Worth every penny.
- January 28, 2008 at 12:46 AM
- Ten out of Ten said...
I haven't had Uptodate since I finished residency, and I miss it. I can usually get by with emedicine and the textbooks, but there have been times unfortunately when they are inadequate.
Also I would like to officially endorse Dunkin Donuts Coffee.
- January 28, 2008 at 9:53 AM
- janemariemd said...
I think Dr RW wrote a post a while back about being "UptoDate dependent", and I did too. I like Google Images for dermatology stuff, especially in the exam room with the patient. UptoDate makes it easy to rack up the CME credits, too, although lately I've been feeling I would benefit from a trip away from the office TO a meeting to get some in-depth knowledge.
I remember the Wash Manual--before it was too big to fit in a white-coat pocket! It WAS the Bible. It's still published I think, but I haven't looked at it in years.
- February 1, 2008 at 1:09 AM
- Dr. Smak said...
JaneMarie - I remembered those posts, but I didn't remember where I had read them. Being the super tech-savvy doc that I am, I have not been able to figure out how to get CME credit from uptodate, tho I know it's a theoretical possibility.
- February 1, 2008 at 7:36 AM
- janemariemd said...
Hi Dr. Smak--after you log in, there's a bar with headings that include "New Search" etc, and "CME" is one of them. Just click on it and follow the directions, it's pretty easy. If you sign in every day and search it like I do, you probably have hundreds of potential CME credits. It makes the rather stiff price worth it I think!
- February 1, 2008 at 6:51 PM
- TBTAM said...
YOu know what I love about up to date? NO PHARMA SPONSORSHIP!!! That's whay it costs to use it. A small price to pay, I say, for medical info without the spin.
- February 8, 2008 at 9:41 AM


text:
Spanish American War Medal Recipients - Michigan
Soldiers at Camp Eaton, Michigan, 1898
Click the lines below to access the name index. Each link notes the first and last name entry of its corresponding index section.
Smith, Wesley - Zylstra, William
The wreckage of the U.S.S. Maine, January 1899
Click Archives of Michigan to visit the Archives of Michigan home page.
Click Archives of Michigan Military Sources Page for other military records indexes.
Archives of Michigan
Michigan Library and Historical Center
702 W. Kalamazoo Street
Lansing, MI 48913
Phone: (517) 373-1408
E-mail: email@example.com
Updated 04/01/2008
Historical Center, Department of History, Arts and Libraries
Use and Reproduction Information [PDF]
Contact us with your question or comment about this page.


text:
My EAS container says 2 of those little scoops per serving. I am trying to find an old GB post on this.....hold the phone.
it's two scoops; I measured it out the other night and I believe it's one full tablespoon for a serving...
DebMO :0) Blessed to be a Blessing...
Okay. I guess I get to add something to my routine then..lol. Good stuff, can't wait to see what impact it will have. wow......
Nope. Serving size is 2 scoops. Have the Betagan container here. Recommended Use and Mixing instructions: mix 2 scoops with 4 oz of cold water. Take 3 servings daily. That's the shortened version
Don't get bummed Armster. Just think...you've got more juice coming towards ya :-)
Keep the faith!
Faithful Renee :0)
For sure! I knew there was a reason I joined this forum :P
Just another comment from memory. This is going to sound weird. I believe I remember hearing to make sure you keep it to the 4 oz. of water. I recall someone saying that if you dilute it with too much water it lessens the effect. I can't remember where I heard that or who from or if it is true. I just follow the instructions on the container...4 oz.
That doesn't make sense because you would be drinking a lot of water very shortly anyway.
I drink it with a tall glass - about 8 - 9 ounces. Otherwise it tastes too sweet for me. And I agree with C - your drinking a small pool every day anyways....
I think the way it works with though, you should be taking it on an empty stomach before and after. It absorbs fairly rapidly as far as I know, so maybe waiting 15-30 minutes to have any water before and after dosing up is the way to do it.
I need advice. I ran out of Betagen...it has 20cal., Creatine 2g, L-Glutamine 2g, Taurine 500mg and Calcium HMB 1g.
I found in my cupboard from 2006 (last attempt of trying to grow muscle obviously) SOY PROTEIN. It has 82 cal, 17g protein, 6.8 carbs and fiber along with 18 Amino acids L-Glutimine being 19.8g! It doesnt have creatine or Taurine.
My question is - is this a good replacement/substitute for Betagen IF I take it plus get a Creatine product to go with it.
It tastes like chalk but wow - look at all the BCAA's in it! Its more than Betagen.
Legs-email BFLMike, I bet he would be able to tell you, that way when you go to the city on Friday (wow that's tomorrow already!) you can be prepared! :)
Im going to really take my time in this new store I located....its called Popeyes. I might just have to drop hubby off at some automotive MAN store and go there alone and really take my time. Im excited.
Yes today is my Friday! Woop! Another long weekend.
Ya, I saw that listed in the Oxygen mag. Jerry's MAN store would be Bass Pro or Cabela's...though I like looking there too...
Oh my - Popeyes is my new favorite store. The guy in there really knew his stuff. I bought the EAS Vanilla Protein stuff, cause it is awesome, then instead of Betagen (which they would have to special order because they think there are better supps out there) I got Kre-Alkalyn (which the guy at the store says is a womans best Creatine because it gives all the benefits but without the swelling/bloating of Creatine....then also I got BCAA's L-Valine, L-Leucine and L-Isoleucine. It is cheaper for me to get the tablets and protein drink than to get Betagen in Canada. I am really impressed with this place Popeyes. He says I can call and get stuff delivered free too. :) He liked that I was doing BFL....they have the BFL book right by their till. Cool.
So I am to take 2tabs of the "Purple-K" (King of Creatine) before I work out, then 2 tabs along with the BCAA's and whey protein AFTEF my workout. The only thing I wont have is the Taurine....and he tells me that is like a booster of energy and it wont be missed with the other BCAA's I am taking.
If anyone has feedback, I am sure interested. I find this part of my health so interesting now. The guy says I will not get jittery or whatever and I can take these supps every day and not overload. Cool.
Would be nice to have these two threads combined....
© Abbott Laboratories,2013


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Autism was not identified before the 1940s. Weren't there any autistic people before this?
Autism was not a new phenomenon starting in the middle of the 20th century, but it needed people like Leo Kannerand Hans Asperger to point out the striking constellation of poor social communication and stereotypic behaviours for others to see it too. Clinicians used the terms 'infantile' or 'early childhood autism' and located it among the neglected population of children who were born 'mentally deficient'. Gradually clinicians became aware that most of this neglected population showed similar problems in varying degrees, and that specialist services were needed to educate children who could not communicate appropriately. They embraced the idea of the autism spectrum. So, just as there has been an increase in the autism spectrum diagnosis, there has been a corresponding decrease in the diagnosis of mental retardation.
But the spectrum idea had even wider implications. The constellation of social impairments and stereotypic behaviours can also be found in people whose intellectual abilities are average or superior. Previously these people would have been regarded as loners or possibly schizophrenic. It turned out that many families had an eccentric uncle, cousin, or grandfather! From the 1990s the diagnosis of Asperger syndrome became hugely popular and preferred to the diagnosis of autism. This popularity also reflected the gradual recognition of outstanding talents in autism, which is particularly visible in people who are also articulate. The loosening of criteria from early childhood autism, which remains rare, to the whole autism spectrum, which is not at all rare, has helped to make autism one of the most frequently used diagnostic categories today. In the US, 1 in 88 people currently have the diagnosis of autism spectrum disorder.


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The Convertibles style is a quality wool, contemporary rug design from Capel Rugs. Convertibles rugs have a hand tufted construction. The sky blue colorway is a beautiful addition to our assortment of blue area rugs.
This site is best viewed under Internet Explorer 7.0 or higher © Copyright 2014 Capel Incorporated Trademarks of Capel Incorporated


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A Mayes County family is mourning the death of a father and son. Early this morning their mobile home caught fire trapping the two inside. It happened on a county road about a mile north of Highway 28 outside Adair. The Reed family's trailer is a total loss. The mother, Darla Reed, was working an overnight shift in Pryor when the flames went up. She got a phone call at 3:00 a.m. telling her her husband and youngest son were dead.
Darla Reed is carrying the only thing out of her family's burned down home that's left untouched by this morning's deadly flames, her dead son's bicycle.
"My dad tried everything to get my little brother out," says Reed's son-in law, Timothy Reed Jr.
Timothy Reed, Jr. and his finance, live next door; they did all they could last night to save their family.
"That was everything, family is everything, I lost my dad, I lost my brother," says Reed.
At 1:00 Wednesday morning, Reed's neighbor woke him up.
"He said your dad's house is on fire," says Reed. I could see the glow of the house over the barn. I pushed his air conditioner out and I started screaming for dad and Skyler."
This was the end of of Summer break for eight-year-old Skyler Adam Reed.
"This was his last day of freedom he starts school tomorrow," says his brother Reed. "He was rambunctious," says Reed's fiance, Janet Crossland. "He was full of energy."
Friends and neighbors tell me, Timothy's father is a well-known mechanic in Mayes County.
"My dad was a hard working man, he worked his hands to the bone, he would help anybody in need," describes Reed.
"All I can say is don't ever take your family for granted because you are never promised tomorrow," says Crossland. "None of us are."
The fire marshal determined the destroyed trailer home did not have a smoke detector in it. He says, if had, it might have saved the father and son's lives. The cause is still under investigation but the fire marshal says it may have been electrical and started near an air conditioner. The family does not have insurance coverage. If you want to help, they have set up a fund at the
IBC bank in Claremore, it's under the Reed family.
Earlier Story
ADAIR, Okla. (AP) — Mayes County authorities say a 53-year-old man and his 8-year-old son have died in a fire that destroyed their mobile home near Adair.
County Emergency Management Director Johnny Janzen says the bodies were found about 6 a.m. Wednesday.
The names of the two were not immediately released. The bodies were sent to the state medical examiner's office in Tulsa for positive identification and to determine the cause of death.
State Fire Marshal's spokeswoman Joanne Sellers says the cause of the fire has not been determined. She says there were no working smoke detectors in the home.
Janzen says the man's wife and mother of the boy was at work at the time of the fire.
©2011 Associated Press. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
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The views expressed here do not necessarily represent those of KOKI FOX23 - Tulsa


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Ms. Elaine Kneeous
Jennifer is a one in a million stay-at-home mom. (More like one OF a million stay at home moms!) She graduated from a liberal arts college but there is nothing liberal OR artsy about her. She is married to Kevin Fischer of This Just In, and together they have a beautiful young daughter Kyla Audrey. In no particular order she loves dogs, wine, a good bargain, her family, pizza, and entertaining. Follow her blog of all things miscellaneous including but not limited to cooking and baking, entertaining and party planning, being a mommy, and homekeeping.
Tips for a Worn Out Mom
I'll credit the author of the post I read on Facebook, Jenn Mast. I'm not sure where it originated. It doesn't matter, it's great. Enjoy, my mommy friends!
Culinary yes-yes #52
You don't always realize how quickly 52 weeks can pass by. When I started my own "Culinary" segment on Ms. Elaine Kneeous one year ago, I had no idea that one year would come & go in the blink of an eye. So here I am, still following in Kevin's foodie footsteps and enjoying every delicious moment. To long-time readers thank you for staying with me. To new friends, thanks for joining me. And now without further ado, let's dive into this week's edition, shall we?
It's a good thing Kyla is slim, and that we don't live in Fargo
I wouldn't want to have the mess (toilet paper, eggs, etc.) to clean up at our home that this woman will:


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Cornell University Library, November 2013
This is an automatically generated list of the latest Non-Juvenile items in WorldCat for this library.
by Kenneth M Pollack
Language: English
Publisher: New York, NY : Simon & Schuster, 2013.
No tags available
by Lauren Coodley
Book : Biography : State or province government publication
Publisher: Lincoln : University of Nebraska Press, 2013.
by United States. Department of Homeland Security. Office of Inspector General,
eBook : Document : National government publication
Publisher: Washington, DC : Department of Homeland Security, Office of Inspector General, 2013.
by John W Lyons; Richard Chait; Charles J Nietubicz; National Defense University. Center for Technology and National Security Policy.
Publisher: Washington, DC : Center for Technology and National Security Policy, National Defense University, [2011]
by United States. Department of Commerce. Office of Audit and Evaluation,; United States. Patent and Trademark Office,
Publisher: Washington, D.C. : U.S. Department of Commerce, Office of Inspector General, Office of Audit and Evaluation, 2013.
by United States. Congress. House. Committee on Veterans' Affairs,
Publisher: Washington : U.S. Government Printing Office, 2013.
by John A Moody; Petter Nyman; Geological Survey (U.S.),
Publisher: Reston, Virginia : U.S. Department of the Interior, U.S. Geological Survey, 2013.
by United States. Congress. House. Committee on Veterans' Affairs. Subcommittee on Health,
Publisher: [Washington, D.C.] : [U. S. Government Printing Office], [2013].
Publisher: Washington : U.S. G.P.O., 2013.
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