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General Information
Congenital Anomalies and Syndromes Predisposing to Wilms Tumor
Screening Children Predisposed to Wilms Tumor
Genetics of Wilms Tumor
Wilms tumor 1 gene (WT1)
Wilms tumor 2 gene (WT2)
Wilms tumor gene on the X chromosome (WTX)
Other genes
Genetics of Familial Wilms Tumor
Bilateral Wilms Tumor
Fortunately, cancer in children and adolescents is rare, although the overall incidence of childhood cancer has been slowly increasing since 1975.[1] Children and adolescents with cancer should be referred to medical centers that have a multidisciplinary team of cancer specialists with experience treating the cancers that occur during childhood and adolescence. This multidisciplinary team approach incorporates the skills of the primary care physician, pediatric surgical subspecialists, radiation oncologists, pediatric medical oncologists/hematologists, rehabilitation specialists, pediatric nurse specialists, social workers, and others in order to ensure that children receive treatment, supportive care, and rehabilitation that will achieve optimal survival and quality of life. (Refer to the PDQ Supportive and Palliative Care summaries for specific information about supportive care for children and adolescents with cancer.)
Guidelines for pediatric cancer centers and their role in the treatment of pediatric patients with cancer have been outlined by the American Academy of Pediatrics.[2] At these pediatric cancer centers, clinical trials are available for most of the types of cancer that occur in children and adolescents, and the opportunity to participate in these trials is offered to most patients/families. Clinical trials for children and adolescents with cancer are generally designed to compare potentially better therapy with therapy that is currently accepted as standard. Most of the progress made in identifying curative therapies for childhood cancers has been achieved through clinical trials. Information about ongoing clinical trials is available from the NCI Web site.
Dramatic improvements in survival have been achieved for children and adolescents with cancer.[1] Between 1975 and 2006, childhood cancer mortality has decreased by more than 50%. Childhood and adolescent cancer survivors require close follow-up since cancer therapy side effects may persist or develop months or years after treatment. (Refer to the PDQ summary on Late Effects of Treatment for Childhood Cancer for specific information about the incidence, type, and monitoring of late effects in childhood and adolescent cancer survivors.)Prognosis
Wilms tumor is a curable disease in the majority of affected children. Approximately 500 cases are diagnosed in the United States each year. Since the 1980s, the 5-year survival rate for Wilms tumor has been consistently above 90%.[1] This favorable outcome occurred despite reductions in the length of therapy, dose of radiation, extent of fields irradiated, and the percentage of patients receiving radiation therapy.[3] The prognosis for patients with Wilms tumor is related not only to the stage of disease at diagnosis, the histopathologic features of the tumor, patient age, and tumor size, but also to the team approach provided to each patient by the pediatric surgeon, radiation oncologist, and pediatric oncologist (COG-AREN9404).[4-7] Patients who develop Wilms tumor in their second decade of life have a poorer survival (5-year survival, 63%) than younger patients with Wilms tumor.[8]
In an analysis of Wilms tumor patients in the Surveillance, Epidemiology and End Results database, adults (n = 152) had a statistically worse overall survival (OS) (69% vs. 88%, P < .001) than pediatric patients (n = 2,190), despite previous studies showing comparable outcome when treated on protocol.[9,10] Adults with Wilms tumor were more likely than pediatric patients to be staged as having localized disease, to not receive any lymph node sampling, and to not receive any radiation treatment. The investigators recommended that all adult patients diagnosed with Wilms tumor should undergo lymph node sampling and that there should be close collaboration with pediatric surgeons and oncologists in treatment planning. The Children's Oncology Group has increased the enrollment age for their Wilms tumor trials to include patients up to age 30 years.[11]Congenital Anomalies and Syndromes Predisposing to Wilms Tumor
Wilms tumor typically develops in otherwise healthy children; however, approximately 10% of children with Wilms tumor have a congenital anomaly.[12] Children with Wilms tumor may have associated urinary tract anomalies, including hemihypertrophy, cryptorchidism, and hypospadias. Children may have a recognizable phenotypic syndrome (including overgrowth disease, aniridia, genetic malformations, and others). These syndromes have provided clues to the genetic basis of the disease. The phenotypic syndromes have been divided into overgrowth and nonovergrowth categories.
- Overgrowth syndromes. Overgrowth syndromes are the result of excessive prenatal and postnatal somatic growth.[13,14] Examples of overgrowth syndromes include the following:
- Beckwith-Wiedemann syndrome (prevalence is about 1% of children with Wilms tumor).[15-18]
- Isolated hemihypertrophy (prevalence is about 2.5% of children with Wilms tumor).[15,19]
- Perlman syndrome (characterized by fetal gigantism, renal dysplasia, Wilms tumor, islet cell hypertrophy, multiple congenital anomalies, and mental retardation).[20] Germline inactivating mutations in DIS3L2 on chromosome 2q37 are associated with Perlman syndrome.[21]
- Sotos syndrome (characterized by cerebral gigantism).
- Simpson-Golabi-Behemel syndrome (characterized by macroglossia, macrosomia, renal and skeletal abnormalities, and increased risk of embryonal cancers).
- Nonovergrowth syndromes. Examples of nonovergrowth syndromes associated with Wilms tumor include the following:
- WAGR syndrome (aniridia, genitourinary anomaly, and mental retardation). The constellation of WAGR syndrome occurs in association with an interstitial deletion on chromosome 11 (del[11p13]).[22,23] (prevalence is about 0.4% of children with Wilms tumor). The incidence of bilateral Wilms tumor in children with WAGR syndrome is about 15%.[24]
- Isolated aniridia.
- Genitourinary anomalies including hypospadias, undescended testis, and others are associated with Wilms tumor 1 (WT1) mutations (prevalence is over 6% of children with Wilms tumor). Children with pseudo-hermaphroditism and/or renal disease (glomerulonephritis or nephrotic syndrome) who develop Wilms tumor may have the Denys-Drash or Frasier syndrome (characterized by male hermaphroditism, primary amenorrhea, chronic renal failure, and other abnormalities),[25] both of which are associated with mutations in the WT1 gene.[26] Specifically, germline missense mutations in the WT1 gene are responsible for most Wilms tumors that occur as part of the Denys-Drash syndrome.[27,28]
- Bloom syndrome.
- Alagille syndrome.[29]
- Trisomy 18.
- Li-Fraumeni syndrome (familial cancer syndrome).
Children with a significantly increased predisposition to develop Wilms tumor (e.g., most children with Beckwith-Wiedemann syndrome, WAGR syndrome, Denys-Drash syndrome, idiopathic hemihypertrophy, or sporadic aniridia) should be screened with ultrasound every 3 months at least until they reach age 8 years.[13-15,30]
Approximately 10% of patients with Beckwith-Wiedemann syndrome will develop a malignancy, with either Wilms tumor or hepatoblastoma being the most common, although adrenal tumors can also occur.[31] Children with hemihypertrophy are also at risk for developing liver and adrenal tumors. Screening with abdominal ultrasound and serum alpha-fetoprotein is suggested until age 4 years; after age 4, most hepatoblastomas will have occurred, and imaging may be limited to renal ultrasound, which is quicker and does not require the child to fast for the exam.[32]
Children with Klippel-Trénaunay syndrome, a unilateral limb overgrowth syndrome, had been considered to be at increased risk for developing Wilms tumor. The risk of Wilms tumor in children with Klippel-Trénaunay syndrome, when assessed using the National Wilms Tumor Study (NWTS) database, was no different than in the general population and routine ultrasound surveillance is not recommended.[33]Genetics of Wilms Tumor
Wilms tumor (hereditary or sporadic) appears to result from changes in one or more of at least ten genes. Several, but not all, will be discussed here.Wilms tumor 1 gene (WT1)
The WT1 gene is located on the short arm of chromosome 11 (11p13). The normal function of WT1 is required for normal genitourinary development and is important for differentiation of the renal blastema. Germline mutations in WT1 have been found in about 2% of phenotypically normal children with Wilms tumor.[34] Germline WT1 mutations in children with Wilms tumor does not confer a poor prognosis per se. The offspring of those with germline mutation in WT1 may also be at increased risk of developing Wilms tumor. Because deletion of WT1 was the first mutation found to be associated with Wilms tumor, WT1 was assumed to be a conventional tumor suppressor gene. However, non-inactivating mutations can result in altered WT1 protein function that also results in Wilms tumor, such as in the Denys-Drash syndrome.
WT1 mutation is more common in those children with Wilms tumor and one of the following:
- WAGR syndrome, Denys-Drash syndrome, or sporadic aniridia.
- Genitourinary anomalies, including hypospadias and cryptorchidism.
- Bilateral Wilms tumor.
- Unilateral Wilms tumor with nephrogenic rests in the contralateral kidney.
- Stromal and rhabdomyomatous differentiation.[25]
The observation that lead to the discovery of WT1 was that children with WAGR syndrome (aniridia, genitourinary anomalies, and mental retardation) were at high risk (>30%) for developing Wilms tumor. Germline mutations were then identified at chromosome 11p13 in children with WAGR syndrome. Deletions involved a set of contiguous genes that included WT1 and the PAX6 gene (responsible for aniridia). Aniridia is characterized by hypoplasia of the iris and it occurs in sporadic or familial cases and has an autosomal dominant inheritance. Mutations in the PAX6 gene lead to aniridia. The PAX6 gene is located on chromosome 13 closely associated with the WT1 gene, deletion of which confers the increased risk of Wilms tumor. Some of the sporadic cases of aniridia are caused by large chromosomal deletions that also include the Wilms tumor gene – WT1. This results in an increased relative risk of 67-fold (95% confidence interval [CI], 8.1–241) of developing Wilms tumor in children with sporadic aniridia.[35] Patients with sporadic aniridia and a normal WT1 gene, however, are not at increased risk for developing Wilms tumor. Children with familial aniridia generally have a normal WT1 gene and are not at an increased risk of Wilms tumor. The mental retardation in WAGR syndrome may be secondary to deletion of other genes including SLC1A2 or BDNF (brain-derived neurotrophic factor).[36]
The incidence of Wilms tumor in children with sporadic aniridia is estimated to be about 5%.[24] Patients with sporadic aniridia should be screened with ultrasound every 3 months until they reach age 8 years, unless genetic testing confirms that they are negative for WT1.[15,30]Monitoring for late renal failure
Children with WAGR syndrome or other germline WT1 mutations are at increased risk of eventually developing hypertension, nephropathy, and renal failure and should be monitored throughout their lives.[37] Patients with Wilms tumor and aniridia without genitourinary abnormalities are at lesser risk but should be monitored for nephropathy or renal failure.[38] Children with Wilms tumor and any genitourinary anomalies are also at increased risk for late renal failure and should be monitored. Features associated with germline WT1 mutations that increase the risk for developing renal failure are stromal predominant histology, bilaterality, intralobular nephrogenic rests, and Wilms tumor diagnosed before age 2 years.[37]WT1 interactions
Activating mutations of the beta-catenin gene (CTNNB1) have been reported to occur in 15% of Wilms tumor patients. In one study, all but one tumor with a beta-catenin mutation had a WT1 mutation and at least 50% of the tumors with WT1 mutations had a beta-catenin mutation.[39,40] That CTNNB1 mutations are rarely found in the absence of a WT1 or WTX mutation suggests that activation of beta-catenin in the presence of intact WT1 protein must be inadequate to promote tumor development.[41,42]
WT1 mutations and 11p15 loss of heterozygosity are associated with relapse in patients with very low-risk Wilms tumor who do not receive chemotherapy.[43] These may provide biomarkers to stratify patients in the future.Wilms tumor 2 gene (WT2)
A second Wilms tumor locus, WT2 gene, maps to an imprinted region of chromosome 11p15.5, which, when constitutional, causes the Beckwith-Wiedemann syndrome. About 3% of children with Wilms tumors have constitutional epigenetic or genetic changes at the 11p15.5 growth regulatory locus without any clinical manifestations of overgrowth. These children may be more likely to have bilateral Wilms tumor or familial Wilms tumor.[36] There are several candidate genes at the WT2 locus, comprising the two independent imprinted domains IGF2/H19 and KIP2/LIT1.[44] Loss of heterozygosity, which exclusively affects the maternal chromosome, has the effect of upregulating paternally active genes and silencing maternally inactive ones. A loss or switch of the imprint for genes (change in methylation status) in this region has also been frequently observed and results in the same functional aberrations. A study of 35 sporadic primary Wilms tumors suggests that more than 80% have somatic loss of heterozygosity or loss of imprinting at 11p15.5.[45] The mechanism resulting in loss of imprinting can be either genetic mutation or epigenetic change of methylation.[36,44] Loss of imprinting or gene methylation are rarely found at other loci, supporting the specificity of loss of imprinting at IGF2.[46] Interestingly, Wilms tumors in Asian children are not associated with either nephrogenic rests or IGF2 loss of imprinting.[47]
Beckwith-Wiedemann syndrome results from constitutional loss of imprinting or heterozygosity of WT2. Observations suggest genetic heterogeneity in the etiology of Beckwith-Wiedemann syndrome with differing levels of association with risk of tumor formation.[48] Molecularly defined subsets of Beckwith-Wiedemann patients may not require ultrasound screening for malignancies. Approximately one-fifth of patients with Beckwith-Wiedemann syndrome who develop Wilms tumor present with bilateral disease, though metachronous bilateral disease is also observed.[15-17] The prevalence of Beckwith-Wiedemann syndrome is about 1% among children with Wilms tumor reported to the NWTS.[17,49,50]Wilms tumor gene on the X chromosome (WTX)
A third gene, WTX, has been identified on the X chromosome and plays a role in normal kidney development. WTX mutations were identified in 17% of Wilms tumors, equally distributed between males and females.[51] This gene is inactivated in approximately one-third of Wilms tumors but germline mutations have not been observed in patients with Wilms tumor.[52]Other genes
Additional genes have been implicated in the pathogenesis and biology of Wilms tumor:
- 16q and 1p: Additional tumor-suppressor or tumor-progressive genes may lie on chromosomes 16q and 1p as evidenced by loss of heterozygosity for these regions in 17% and 11% of Wilms tumors, respectively. Patients classified by tumor-specific loss of these loci had significantly worse relapse-free and OS rates. Combined loss of 1p and 16q are used to select favorable-histology Wilms tumor patients for more aggressive therapy in the current Children's Oncology Group study.[53]
- CACNA1E: Overexpression and amplification of the gene CACNA1E located at 1q25.3, which encodes the ion-conducting alpha-1 subunit of R-type voltage-dependent calcium channels, may be associated with relapse in favorable-histology Wilms tumor.[54]
- 7p21: A consensus region of loss of heterozygosity has been identified within 7p21 containing ten known genes, including two candidate suppressor genes (Mesenchyme homeobox 2 [MEOX2] and Sclerostin domain containing 1 [SOSTDC1]).[55]
- SKCG-1: Genomic loss of a growth regulatory gene, SKCG-1, located at 11q23.2, was found in 38% of examined sporadic Wilms tumors and particularly the highly proliferative Wilms tumors. Additional studies of si-RNA silencing of the SKCG-1 gene in human embryonic kidney epithelial cells resulted in a 40% increase in cell growth, which suggests that this gene may be involved in loss of growth regulation and Wilms tumorigenesis.[56]
- p53 tumor suppressor gene: A small subset of anaplastic Wilms tumors show mutations in the p53 tumor suppressor gene. Although it is unlikely that it plays a major role in Wilms tumorigenesis, it may be useful as an unfavorable prognostic marker.[57,58]
- FBXW7: FBXW7, a ubiquitin ligase component, has been identified as a novel Wilms tumor gene. Mutations of this gene have been associated with epithelial-type tumor histology.[59]
- MYCN: Genomic gain or amplification of MYCN is relatively common in Wilms tumors and associated with diffuse anaplastic histology.[59]
Despite the number of genes that appear to be involved in the development of Wilms tumor, hereditary Wilms tumor is uncommon, with approximately 2% of patients having a positive family history for Wilms tumor. Siblings of children with Wilms tumor have a low likelihood of developing Wilms tumor.[60] The risk of Wilms tumor among offspring of persons who have had unilateral (sporadic) tumors is less than 2%.[61] Two familial Wilms tumor genes have been localized to FWT1 (17q12-q21) and FWT2 (19q13.4).[62-64]Bilateral Wilms Tumor
About 4% to 5% of patients have bilateral Wilms tumors, but these are not usually hereditary.[65] Many bilateral tumors are present at the time Wilms tumor is first diagnosed (i.e., synchronous), but a second Wilms tumor may also develop later in the remaining kidney of 1% to 3% of children treated successfully for Wilms tumor. The incidence of such metachronous bilateral Wilms tumors is much higher in children whose original Wilms tumor was diagnosed before age 12 months and/or whose resected kidney contains nephrogenic rests. Periodic abdominal ultrasound is recommended for early detection of metachronous bilateral Wilms tumor as follows:[63,64]
- Children with nephrogenic rests in the resected kidney (if younger than 48 months at initial diagnosis)—every 3 months for 6 years.
- Children with nephrogenic rests in the resected kidney (if older than 48 months at initial diagnosis)—every 3 months for 4 years.
- Other patients—every 3 months for 2 years, then yearly for an additional 1 to 3 years.
Clear cell sarcoma of the kidney, rhabdoid tumor of the kidney, neuroepithelial tumor of the kidney, and cystic partially-differentiated nephroblastoma are childhood renal tumors unrelated to Wilms tumor.[66,67] (Refer to the Cellular Classification section of this summary for more information.)References
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- Breslow NE, Beckwith JB: Epidemiological features of Wilms' tumor: results of the National Wilms' Tumor Study. J Natl Cancer Inst 68 (3): 429-36, 1982. [PUBMED Abstract]
- Ahmed HU, Arya M, Levitt G, et al.: Part I: Primary malignant non-Wilms' renal tumours in children. Lancet Oncol 8 (8): 730-7, 2007. [PUBMED Abstract]
- Ahmed HU, Arya M, Levitt G, et al.: Part II: Treatment of primary malignant non-Wilms' renal tumours in children. Lancet Oncol 8 (9): 842-8, 2007. [PUBMED Abstract]


text:
Found the same room at a different price? Tell us, and we'll offer to match it.
Hotel Indigo Birmingham
|Self Classified Hotel
|Ratings explained
The hotel takes on the terminology Refreshingly Local taking elements of design from the surrounding area. Everything about this hotel has been designed to make your stay in Birmingham exceptional. From the breath-taking panoramic views from the Marco Pierre White Steakhouse & Grill to the tranquillity of the prestigious Club and Spa , Hotel Indigo is bursting with personality. Ideally located in the heart of Birmingham and only minutes from the M5 and M6 motorways, this sophisticated venue is the perfect city destination. Our central location guarantees easy access to all major sports and events venues in Birmingham, the ICC, NIA and Symphony Hall are all within 5 minutes' walk from the hotel.

subset: commoncrawl


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Arjan wrote:wbond wrote:Have you tried setting "index_files" to false?
Yes, that obviously "fixes" the problems, but I need to have it on.
It's not at all obvious to me. Just to be sure, can you confirm that you did indeed try this and that the symptoms disappeared after turning it off?


text:
Empower your CrazyTalk Animator creations with DrawPlus X5's professional draw and paint capabilities. DrawPlus X5 from Serif is not only a fully-featured graphics tool, but also a proven content design pipeline for CrazyTalk Animator. It brings data compatibility and ease-of-use to CrazyTalk Animator designers, as it saves time and effort on full scale Adobe Flash and Photoshop projects. With DrawPlus X5, now you can combine the power of image paint, vector draw and animated Flash content (SWF) in one complete toolbox.
With ready-to-use designs and on-screen galleries of instant art and symbols that
get you started fast.
Simply drag in content, export in PNG or SWF, and create instant animations in CrazyTalk
Animator. Find over
4,000 greatly augmented vector materials which include; clip arts, business logos,
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Collect different types of media and enrich your accessory and prop library in just
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In DrawPlus X5 you can find separate facial parts like eyes, nose and mouth, which allow you to reassemble your actors inside the Character Composer system for many actor combinations.
Grab your business logo templates and ungroup them to easily change text, shapes or further modify.
Show your concepts, in motion, with geometric figures and paradigms.
Excellent banner, button and graphic creation tool. Simply re-arrange templates and geometric figures to design custom banners, icons and signboards in just a few clicks.
Simply lay out your interiors with flexible,
editable space figures and previsualize your concepts and ideas with guided CrazyTalk avatars.


text:
Body For Life is simply amazing. I haven't arrived where I want to be yet. Still have some weight to lose. And as you can see from the picture, I still have some clothes to buy :) Like I said before, the most expensive part about this program is not the myoplex shakes, it is the money you have to spend on new clothes because none of your old ones fit anymore!!!!
I posted a few days ago but did not have the pics until now. I went from 246 to 215. I went from a size 42 to a size 34!!!
Also, I wanted to encourage anyone starting out to do the body for life workbook. That helped me tremendously. It really helped me go to the gym. When you lie down at night and write out your workout for the following day it is half the battle. It makes getting up to go to the gym easy.
Congrats! what an awesome achievement. I am starting today and it is great to see what is possible.You look terrific.
Awesome! Congratulations :) I love seeing befores and afters. It is SO motivating. You look great.
Congratulations! You look fantastic. You should be very proud!
Wow! Great job, and a FSU fan to boot! Double win in my book!
Congrats! What a change!
Way to go FSU! Awesome results that will just keep getting better! That's the beauty of BFL. To me, it's the only program that is maintainable. It is just right; not too difficult with the workouts or strict with the nutrition. This is a program that you could ACTUALLY do for life and not feel like you are missing out on anything. And I love being able to eat within the guidelines without all the measuring, counting calories or points like Weight Watchers and some others. Keep up the good work and be sure to post your C2 pictures when you're done. You are motivating the masses, my friend!
Wow, You really lost some weight and gained some muscle as well. Great work and well done. Best wishes always!!!
Kickass! I hope my results are as pronounced!
Well done!
t believe the FANTASTIC! What tremendous results. I can't believe the waist size difference! shopping for new clothes will be tons of fun. I need to show my hubby your photos. Maybe he'll decide to do this. Thanks for sharing.
Congrats, FSU! Amazing results!
Come visit my blog!
Whether you think you can or you think you can't, you'll be right!
Thank all of you for the encouragement! I hope the program is working for you all! Tomorrow I start challenge 2. Best of luck to all of you.
Nice job!!!
Good Job!! Way to go!
© Abbott Laboratories,2013


text:
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My Settings
posted 2/26/2009 by
Tyler Sager
other articles
by Tyler Sager
First and foremost, Savage Moon is a "tower defense" game. It's actually quite a good one, but there's nothing here to woo players who just can't get into this type of title. That being said, there are oodles of bug-splattering goodness packed into this little gem, and the price makes it almost impossible to pass up for fans.
On first glance, there's really not all that much to Savage Moon or any other title in this genre. On a given map, there are spawn points for alien creepy-crawlies of all kinds, and there's a base to protect. In a series of waves, these space bugs emerge from their lairs and crawl or fly across the map, attempting to destroy the base. Players try to prevent this by installing various offensive and defensive towers in the bug's path. Each tower costs money, and there are a limited number of tower drops available. Killing bugs gains more money, to be used to buy more towers, to kill more bugs. As dry as that sounds, this all happens at a breakneck speed, with funds always too limited and the bug swarms always on the brink of overwhelming.
In each map, players start out with access to a basic machine-gun tower. As funds increase, players may spend money researching many more powerful tower types, as well as upgrading current towers for increased firepower. Each tower type has its specialty, focusing on air- or ground-based targets, attacking groups or single enemies, or bolstering other towers. Towers may only be placed in limited areas of the maps, so players must carefully consider how best to arrange their defenses to blast the waves of enemies as they march toward their target. Should too many bugs get through to the home base, it's time for a restart.
In an interesting twist to the tower defense genre, Savage Moon allows players to make a global change to all their towers on the fly. This setting allows players to concentrate on increasing cash rewards for bug kills, increasing damage of their towers, or increasing the tower's durability. Since nothing is ever easy, choosing one of these settings lowers the other two. I would often find myself setting up for more cash on the early waves, and then toggling between attack and defense later, depending on the types of enemies currently swarming the map.
For a budget title, Savage Moon looks great. The controls are also very smooth and intuitive, allowing players to access the various menus easily, even when frantically dealing with an insect onslaught. The sounds of the little buggies going "squish" were fun at first, but after a while they grew a bit stale. As for difficulty, Savage Moon is just plain brutal. The first few levels are a nice, hand-held walk in the park, after which the game smacks players around for another ten or so maps. Several playthroughs are necessary for each level, so players can learn the attack patterns of the various waves. And the end-wave bosses are appropriately rough, often requiring several waves of preparation themselves. Of course, those preparation waves are the toughest of the level, meaning players must continue to hold off the hordes while frenetically attempting to hammer together a final defense (one that sometimes comes from a completely new spawn point on the map). This is not for the faint of heart, nor for those with little patience. Fans of the tower defense genre, or those wanting to check out what all the fuss is about, would do well to give this title a look. For a bargain price and a quick download, Savage Moon will leave players blasting those little buggies with glee.
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Sherman Home » Library-resource » Resource Tools and Library Resources
If you have problems using any of these resources (or any others), or if you'd like to learn more, please don't hesitate to ask.
Our most fundamental goal is to serve our patrons (that's you!), and we are always happy to do so. We'll do whatever we can to make your information search go as smoothly as possible. Feel free to stop by, email our Director of Learning Resources, Facebook the LRC, Tweet in our direction, pick up the phone or send a carrier pigeon.
Access the Library Catalog
When you're on campus
When you're off campus
The resources linked below are a combination of subscription databases and free web-based research sites. Please use caution when using materials from the open web, as not all research is peer-reviewed and may therefore not be deemed acceptable by your professor.
TIP:If your topic is related to chiropractic, the Index to Chiropractic Literature (also linked below) is generally the best place to start. Full-text is not usually available online via ICL, but the LRC should have print copies of most materials indexed by ICL.
NOTE: Although the LRC does provide Interlibrary Loan Services, we require a minimum of one week's notice for all ILL requests. We cannot guarantee when or even IF an article will be delivered via ILL. The availability of any given article is completely dependent on whether or not the item is owned by another library that is willing to provide an ILL copy for free, as well as the other library's processing timeline, which varies widely by institution.
PLEASE NOTE: Subscription resources are denoted by the [S] symbol following the resource title.
Some require a password for on- or off-campus access; some will only require a password if you're off-campus.
For instructions for accessing these sites, please visit the Learning Resources Center Blackboard page.
Index to Chiropractic Literature
Online index providing access to bibliographic records for peer-reviewed literature produced by chiropractic publishers.
Full-text is not generally available via ICL. However, the LRC subscribes to many of the materials whose bibliographic records can be retrieved using ICL.
We also offer Interlibrary Loan services for items we do not own, but we cannot guarantee delivery times for any requested materials. ILL request forms can be found under "Forms & Resources" above.
PubMed is a government resource (managed by the U.S. National Library of Medicine and the National Institutes of Health) that provides online access to materials related to health science. Some access is full-text, but many are limited to abstract only.
If you locate an article of interest that is only available as an abstract, please see the LRC staff for further assistance. We will be glad to help you to determine whether the school has on-campus access to the material in question.
We also offer Interlibrary Loan services for items we do not own, but we cannot guarantee delivery times for any requested materials. ILL request forms can be found under "Forms & Resources" above .
National Center for Complementary and Alternative Medicine (NCCAM)
Searching PubMed via the NCCAM site will automatically limit your search results to those related to Complementary and Alternative Medicine.
MANTIS is the world's largest (300,000+ records) chiropractic, osteopathic and related research database, covering publications dating back to the early 1900s.
DISCUS (Digital Information for South Carolina Users)
Full-text access to more than 50 databases and resources, including:
* Academic Search Premier
* Small Business Reference Center
* Consumer Health Complete
* Alt HealthWatch (via EBSCOHost web)
* Health Source (via EBSCOHost web)
* MEDLINE (via EBSCOHost web)
This link will work from anywhere within South Carolina. If you are a currently enrolled student living outside of South Carolina, please contact us for login credentials.
McCoy Press Journals [S]
Full-text online access to:
* Journal of Maternal, Pediatric and Family Health - Chiropractic
*Annals of Vertebral Subluxation Research (formerly JVSR)
* Journal of Upper Cervical Chiropractic Research
*Dialogues: The Journal of Philosophy, Principles and Practice of Chiropractic.
National Library of Medicine (NLM)
This search engine, created by the National Library of Medicine, simultaneously searches multiple government health-related resources.
Here's a list of the sites that are searchable via NLM Gateway.
A simple search for chiropractic returns nearly 6,500 records. To search these records for items related to another research topic (i.e. sports, fibromyalgia, blood pressure, etc.) simply add:
AND [your topic of interest]
to the search window.
BioMed Central (BMC)
BMC provides free access to full-text articles in the fields of science, technology and medicine.
Users can browse resources without registering, but (free) registration is required in order to use the search function.
The Chiropractic and Osteopathy section of the site may be of particular use to students.
Primal Pictures - Functional Anatomy [S]
Online database of 3D anatomy images, movies and animations. For off-campus login information, visit the LRC's Blackboard page.
EBSCOhost Electronic Journal Service [S]
Full-text electronic journals; email us for your unique login information.
Directory of Open Access Journals (DOAJ)
Maintained by the Lund University Libraries in Lund, Sweden, DOAJ provides one-stop, full-text access to over 5,000 open-access scientific journals.
Approximately half of those journals can be searched at the article level; the rest can be browsed by journal title or subject.
Physiotherapy Evidence Database
Created by the University of Sudney, the Physiotherapy Evidence Database (PEDro) provides free access to over 16,000 bibliographic records for randomized trials, systematic reviews and clinical practice guidelines in the field of physiotherapy. PEDro provides citation information for each item and links to full-text resources wherever possible.
Highwire,which is maintained by Stanford University, provides access to over 1,300 journals (some full-text), books and other reference works created by independent scholarly publishers, university presses and other groups.


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When my state's 2012 Republican primary is held Mitt Romney will not be receiving my vote. I'd asked all who see this to consider another candidate as well.
Why you ask?
Because of this: As MA Governor Romney, consulted with one, John Holdren, on climate change/carbon admissions matters. Holdren, a Harvard Professor with standing in the earth science field on the surface appears to be a valid 'expert' with whom to consult. Had Romney investigated Holdren's past the kookie views Holdren supports should have excluded him as a Romney advisor.
My problem with Romney is:
- Either he did not vet Holdren before seeking his advice
- Or he did vet Holdren and still sought his advice,
Holdren is well know as "an advocate of de-developing America and population control", that view to some feel makes his advice better suited to be an advisor to the savage Cambodian ruler Pol Pot, rather than a MA Governor.
Holdren's 1977 book Ecoscience, co-authored with Paul & Anne Ehrlich, supports "state-enforced abortions for undesirables and the mass sterilisation of humans through drugs in the water supply, the book argues for the creation of a "Planetary Regime". BTW this book is $199 used.
Note that today John Holdren is Obama's Science Czar.
Read all about in James Delingpole's Ricochet.com post Romney's Poor Judgement.
Might as well vote for Obama!! (ain't gonna happen)


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The late 1990s had a surge of popularity in professional wrestling. The WWF is a big reason for this surge and the Monday Night Wars was a great interprogram rivalry between the WWF and WCW. The ratings contest between the WCW and WWF was neck and neck until about June of 1996 when the WWF took a dive but then in March of 1998 the WWF and WCW got into a dead heat in ratings again until the WWF took the ratings by storm and flew past the WCW to never look back again in March 1999. What happened in that time period that went from the WWF's lowest rating at the time of about 1.5 in December 1996 to steadily increase to its highest rating of about 8.1 in June 1999?
Stone Cold Steve Austin: Originally came onto the scene much earlier in his career, Austin became a star in the WWF from 1996 up until his retirement in 2003. In 1997 the fans fell in love with his rule breaking antics when he was eliminated in the Royal Rumble but snuck back into the ring without the officials seeing. A rivalry with Austin and Bret Hart led to Hart defeating Austin in a Submission match at Wrestlemania 13, where Austin passed out in a puddle of his own blood as Hart relentlessly held onto his patented Sharpshooter. Austin's biggest contribution to the popularity surge is the rivalry between him and boss Vince McMahon in 1998-1999. Austin flipped off McMahon and gave him the occassional Stunner. He then kidnapped McMahon and held him in the ring at gunpoint, which was a toy gun that had a sign reading "Bang 3:16." Austin also soaked McMahon with a beer mobile driven up to ringside, poured cement into McMahon's car and much more. At Valentine's Day Massacre, Austin and McMahon squared off in a steel cage. This match began with a bloodied McMahon, after Austin hit his head off the cage causing him to fall through the announcer table.
The Ministry of Darkness: In my opinion this was the greatest group of WWF history. October 1998 (when the WCW and WWF were again tied in ratings) the Ministry began its formation. Led by the Undertaker, the Ministry was one of the most entertaining and contraversial groups of all time. The Undertaker's henchmen, the Acolytes (Farooq and Bradshaw), abducted other WWF athletes to convert them to the dark side. Dennis Knight and Mabel are 2 that were abducted by the Acolytes to become Mideon and Viscera, respectively. The Brood (Edge, Christian and Gangrel) was also recruited by the Undertaker at this time. The Ministry during this time crucified Stone Cold, abducting Ken Shamrock's sister Ryan and Stephanie McMahon, burned a crucifix on Vince McMahon's front lawn, hung the Big Boss Man from the Hell in a Cell, burning Stephanie McMahon's teddy bear, the torture of its own member Christian and the Brood's ritual blood baths.
The Hardcore Championship: The hardcore title was 1st awarded to Mankind in November 1998. This belt added much entertainment as wrestlers involved in these matches were able to use many varieties of objects to win the match. This belt began a rivalry between Al Snow and Hardcore Holly in which the 2 squared off in Feb 1999 at Valentines Day Massacre. The 2 wrestlers took the match into the Mississippi river where Hardcore Holly eventually won the match. The Hardcore title also sparked up one of the most disturbing rivalries of WWF history. Al Snow and the Big Boss Man in the fall of 1999. The feud began over Al Snow's dog Pepper. Boss Man went to the point where he kidnapped Pepper, cooked the dog and fed it to Al Snow. This led to one of the oddest matches, the Kennel from Hell match, where a cage and hell in a cell were combined as rottweilers were running around the outside of the ring locked inside the cell.
New Variety of Matches: The Hell in a Cell, Inferno Match, Hardcore Match, Buried Alive Match, TLC Match, I Quit Match, Ironman Match, Bra and Panties Match, Empty Arena Match, Boiler Room Brawl, 1st Blood Match, Kennel from Hell Match and Table Match are among the many popular matches either added or brought back in the late 1990s. Nobody can ever forget the Hell in a Cell Match between Mankind and the Undertaker when Mankind was thrown from the cell through the announcers table. Kane vs the Undertaker in the inferno match that ended with Kane being set on fire. The numerous Buried Alive Matches with Stone Cold vs the Undertaker, Vince McMahon vs Undertaker and Mankind vs Undertaker were very entertaining. The TLC match with the Hardy Boyz vs Dudley Boyz vs Edge and Christian in 2000 remains as 1 of the best tag team matches ever in wrestling history. The Rock made Mankind submit in the 1st ever I Quit Match in WWF history. Bret Hart vs Shawn Michaels Ironman Match remains the most memorable match of all time in which Shawn Michaels held off the Sharpshooter for a grueling 30 seconds to drive the match into sudden death overtime. The Bra and Panties match between the WWF Divas brought on great reception among the male audience. The Rock vs Mankind Empty Arena Match during halftime of the Superbowl and Mankind vs Undertaker in the Boiler Room Brawl were great matches. Kane bloodied Stone Cold to win the 1st Blood Match while Al Snows rivalry with Big Boss Man sparked the Kennel from Hell match. The uprising of the Dudley Boyz table antics brought about the incorporation of the Table Match as well as many other matches incorporated into this grand time period of WWF history.
New Faces: Kane, Mankind, Stone Cold, Triple H, The Rock, Edge, Farooq, The Hardy Boyz, Al Snow, Ahmed Johnson, Ken Shamrock, The Big Show, Kurt Angel, Steven Richard, Mark Henry, Val Venis, Godfather and many many more joined the WWF during this time period. Kane, Mankind and Al Snow added a dark and deranged setting while Stone Cold and Triple H played in as the bad ****. The Rock was the fan favorite while Steven Richards was booed viciously. The Hardy Boyz brought on highflying exciting while The Big Show used his massive frame and brute strength. Farooq and Ahmend Johnson where big muscle men and Edge was a combination of power and agility. Former Olympic wrestler Kurt Angel and UFC fighter Ken Shamrock stepped foot inside the ring. The Godfather was the pimp while Val Venis was the lover.
The Divas: The Godfather's "hoetrain," Jerry Lawlor cheering to see "puppies" and the new sexual twist of the females in the WWF was huge amung male viewers. Sunny, Marlena, Sable and Chyna quickly eclipsed Jacqueline and Luna in popularity. Other Divas attracting the male viewers include Lita and Stephanie McMahon and later on include Trish Stratus, Molly Holly and Stacy Keibler.
These are some of the many reasons why I believe that the time period from 1996-2000 has been the best 5 year time period for the WWF and why from December 1996- June 1999 the WWF's ratings went up about 6.6 points from a 1.5 to an 8.1.


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[quote user="fhaye27"]I am jaz wondering y is maria sitted in the box of novak in mens finals in us opn???[/quote]
Yes......she was there .
Hey I dated Maria for a while, but had to dump her ... she wouldn't return my balls! . lmao.. wow that was bad..okay.. another coffee
I'm sure she will find the right guy, eventually. She seems like kind of a party girl type.. so hope she can attract some nice guys too.
wat do you think will maria will like in a guy???
me!!!!! lol
I wish badly
lol...sure mysterious joe that she will pay attention to u...if u wish that so badly
What do u mean?
[quote user="shrapi"]Maria beeing a guy, al our male fans would turn to be homo.[/quote]
hahaha, you mean if she was a born male, or if she's going to turn in to a male[:p]
and then she'll play in ATP may be she'll be Demetry Sharapov
Do u mean, What do you think Maria will like in a guy?


text:
Out of the Humidor
CA Readers
From the Print Edition:
Michael Jordan, July/August 2005
Dear Marvin,
My son and I are new to Cigar Aficionado and relatively new to cigar smoking. My son is a freshman in the Ivy League, and apparently part of a proper Ivy education is the ability to choose and enjoy a fine cigar. Naturally, the fraternities handle this part of the education. My son has enjoyed many premium cigars at a downtown cigar bar.
Naturally, he has infected his father with this latest passion, purchasing a humidor for me and sending an occasional cigar home for my consideration. Although there is a lot to learn, it has given us much to discuss and research on the Internet. Many of our regular conversations turn to the latest information from the Cigar Aficionado web site or purchases made based on the magazine's Tasting Highlights. My son has assembled an impressive collection of premium cigars and we are presently setting up a larger humidor for aging. A recent family trip to California became an opportunity for us to explore some fine cigar shops in the San Francisco area. This summer, I will be traveling to Tampa Bay for work, and my son and I are planning another cigar safari.
Cigars have given us a subject to explore and learn together. We haven't enjoyed that kind of common ground in a number of years. It is difficult to keep in touch with a college-age son, but cigars have helped bridge the gap. Thanks to Cigar Aficionado for all your help and information.
Rich Dulay
Morrisville, Pennsylvania
Dear Marvin,
I just picked up the June 2005 issue of your magazine and was heartened to see that Cigar Aficionado continues to fight for the rights of smokers. As a college student, I have been a cigar enthusiast for three years now. Since taking up the hobby, I have met with resistance and downright disdain by the anti-smoking zealots both on and off campus. Unfortunately, they continually lump cigar and pipe smokers together with common cigarette users.
It is important that cigar smokers continue to make the distinction between the hobby and passion that is cigar smoking, and the quick nicotine fix associated with cigarettes.
Froston Back
Fort Gibson, Oklahoma


text:
Series 1 - Episode 5: Dubai
Jason and Pollyanna are in the Middle East to sample the delights of a solar barbecue, review the latest mobile phone games and test cameras in Dubai.
Jason and Pollyanna do a bit of urban jet skiing, modify a pick-up truck, test the navigational capabilities of a smartphone against a standalone SatNav, check in to one of the most hi-tech hotels in the world, and road-test headsets on the East River.
Jason and Pollyanna are in the Middle East to sample the delights of a solar barbecue, review the latest mobile phone games and test cameras in Dubai.
The team try out a revolutionary skateboard and a remote control boat in America's Golden State.
The dynamic duo test gadgets in the Alps and Monaco including the incredible Rollerman body suit.
Bring back suzie jon and otis, get rtd of pollyanna. puf fhe show back to the od format.
I don't even want to watch this When will they bring back the normal gadget show??
perfect for me no buffering but adverts are annoying
well works just fine for me no speed issues at all. Adverts always suck when watching online as they never used to be there and this is y ppl started watching oline to get away from them. Currys is crap and they wouldnt care who they assosiate with, they would sponcer hitler if he gave them good coverage and if your not in UK and wanting to view it look up the details for a 'Proxy Server' The internet is global ppl sites should not be confined to one contrey
How long will it be before they actually decide to look at this problem. Every time most if not all try to view the Gadget Show we are faced with video that is never watchable, I just can't be bothered with it anymore. Sooner they realise that people are turning off and not coming back the sooner they will fix it. I'll not be back
NOO im from denmark and it says "the video your currently trying to wacth cannot be viewed from your current country or location
Gadget show is brilliant but this website is crap, it doesnt stream properly yet adverts work fine, its obvious that this is just a money spinning website but can I remind the owners that for all of us that experience poor streaming we will not visit again and you will loose a massive number of hits. If I were Currys I would not want my brand subconciously connected with the poor experience that this website delivers! SORT IT FIVE!!!
Nothing works for me on this shite site
The streaming of this video is just so slow, stopping and starting every 40 seconds, i love the gadget show, but this has ruined the experience for me. please sort it!
Love the show, but please bring back the classic gadget show!!
Demand 5's video player is totally GARBAGE, seriously need to sort this out, I spend more time refreshing the page and watching ads, than watching what I came to watch. Please sort this out!
This comment was removed by a moderator
This comment was removed by a moderator
For a show tht tests the latest high tech gear out there... their video streaming in truely awful !
why do the adverts keep interrupting the streaming?
Why still using flash!!!!!! Just watched iPad on tv outdoing the kindle fire so why no html5 here? Tell me when your site will be updated.
love gadgets but find some of the tests on muti thousand pound extremes pointless to me and perhaps many more, we cannot afford them even if they were available would also prefer the prizes on offer to be split more evenly between several winners rather than one individual which is too many to accommodate anyway
why can't they get the adverts to stop interrupting the streaming? I keep having to refresh it.
Could the Gadget Show do a round up of UK ISP download and upload speeds in different towns. I live in Reading and pay O2 nearly thrity pounds a week for 20 kbps download and 1.7 kbps upload but get no more than 5 down and 1 up. Regardless the Gadget Show is superb and always leaves me impatient to see the next episode. Might have something to do with Polyanna being so jaw-dropping-beautiful.
Adverts stream great but the actual gadget show video constantly starts and stops. Plese fix this webmaster.
This comment was removed by a moderator
Ipad 4G. Shame the 4G doesn't work in the UK. Even when we get full 4G, it wont be the same type. So Jason should have just run it with a 3G sim to give a fair comparison.
Very jealous of Jason and Pollyanna, would love to go to the big apple. especially with all them gadgets. can you take me next time please ? I can make myself fit in a suitcase :)
This comment was removed by a moderator
Terribly slow for me! Has just started to speed up.
First, is this going to be put up soon?


text:
by FreecasterTV
Thursday Aug 27, 2009
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A Waterlust film about women in water
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A versatile, capable, yet amazingly simple Fletcher for picture-perfect DIY fletching! It can be easily adjusted to perform 3, 4, 5 or 6 fletches in any combination, and works with arrow shafts 13/64" to 27/64".
The indexable upper shaft support is designed to hold each size shaft perfectly centered through the use of exact sized and numbered slots. The shafts cannot move while applying the fletching. Will also fletch cock feather up, down or any other angle. We've also got extra Clamps, in Left Wing, Right Wing, or Straight, available below.
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Return to Slime Smart Spair Tire Repair Kit wtih Compressor Product Page
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Comments On Oct 24, 2007:I have taken this on 4 and 5 day road trips with friends and had to use it only once but it fixed the tire and got us to a cycle shop for the repair. This is a must have for anyone who doesn't have road side assistants.
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Discover Ferrari men polo-shirts for all Ferrari fans. Purchase short sleeved and long sleeved polo-shirts with different colours and models. Choose your favourite and buy it online at Ferrari Store in few easy steps.
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Social Science Data Services
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Punch on: Open thread 07/02/2013
We're all thinking about Tassie this morning. What a terrible weekend the island state has had.
We hope your loved ones are safe. What else is on your mind today?
Comments on this post will close at 8pm AEDT.
Most commented
workers united says:
Labor HAS to win the election 2013 to stop Abbott and the Liberals destroy all the good work done in defending the worker. Dont forget workchoices is being written right now !
Doc says:
Thanks for the spurt of tea across the monitor…
Wow. Still enjoying the effects of some NYE beverages are we?
ramases says:
And that would be a bad thing because. Look at the state this country is in now with the Unions being allowed to run rough shod over the employers time and time again. Look at the wage increases of the last couple of years where there has not been one iota of increased productivity included in the agreements. Its time some sanity was returned to the workforce and employers allowed to dictate the terms and conditions of employment as they are the ones who pay the wages not the unions and without the employers there will be no jobs.
ramases says:
Was reading with interest the article about those young women, girls, who killed themselves yesterday in an horrific car crash and the outpouring of grief that has followed. Lets get it right. They stole the car involved, they were using the words of one of the people at the party drunk and they wanted to go for a joy ride.
Now I don't know about anybody else but I feel no sympathy for them as they knew what they were doing and its a blessing that they happened just to kill themselves and not run head long into an oncoming vehicle and killing the occupants of that as well.
Call me old fashioned or whatever but people who do this sort of thing and then suffer the consequences don't deserve sympathy from anybody just condemnation for being foolish and irresponsible.
Another thing, if they were only 16 and 17 why were they drinking in the first place. Their friends need a reality check before they start paying tributes to these girls as they broke the law and paid the price but such is the mindset that people will forgive the true facts and paint these girls as victims. The only good thing to come out of this is that they managed to just kill themselves and not some innocent bystanders.
TimB says:
During the weekend's Open Thread, I posted an line of dribble spouted by James Hansen to prove a point. Tim chastised me for 'not listening to the scientists'. Which led to me incredulously asking the question 'Exactly who is it do you think I'm quoting?'
The response I got was even more flabbergasting. According to Tim, I apparently quoted someone 'who isn't a climate scientist'.
Tim, please click on the below link and educate yourself.
Now come back and tell me A) that he's not a climate scientist, and B) that I have no basis for ridiculing this man's views, along with every other fool who agrees with him.
Knemon says:
Re Tassie, I feel for the people who have lost everything, terrible. I also can't think of a greater group of people than the fire-fighters and volunteers, absolute champions.
I've also heard that some car rental companies are charging for non return of hired vehicles even though it is physically impossible to return them due to roads being closed, they should be named and shamed.
PJ says:
Like a paragraph straight out of Lindsay Tanners book, that portrays a Gillard Government driven by polls, clueless and pointless, except in the determination to get Julia Gillard re-elected at whatever cost. We read in The Australian that the vacuous narcissistic Gillard government spent a record $35 million of our taxes on market research last year, trying to understand how it could manipulate Our thinking on the carbon tax, broadband, smoking and private health insurance.
The Australian reported an excessive orgy of opinion polling, focus groups and customer surveys, which over 4 years added up to $126million dollars of our taxes.
This startling information adds to the concern that was raised when we found out the Gillard Government had a 1600 strong army of Spin Doctors at a cost of $150 million per year of our taxes, to mould your thinking towards their way.
$126 million + ($150 million x 4)=
Scary waste of our tax dollars on the survival of a fractious political party, that surely we've all had enough of by now. How can a political party justify using taxes collected for Australia, to advance their political party aspirations? Is that Right in your book?
Is using the resources of the Australian nation not an unfair advantage over an opposition party, which can only rely on donations to fund its message?
Is it getting a little Orwellian around here?
We'll never know the truth of it under a Government they lead.
Ben C says:
Is it just me, or has anyone else had problems getting onto the Punch's homepage? When I click on the Punch banner at the top of the page, or manually type in the address, I get a page showing nothing but "Disallowed Key Characters".
Punch team, can you check this out?
Janey says:
I rather enjoyed waiting 30 minutes this morning to inform Telstra that it is illegal to invoice me: "14 calls = $139". Looks like another complaint to the telecommunications ombudsman and more compo from Telstra. Keep it up losers, your crap service ends up paying me every time.
T says:
I recently had a chat with my Father, who my Mother left when I was 3 years old, and moved us 7 hours away when I was 6.
He told me after a bit of force (he would never and still doesn't want to say anything bad about her to me), that the day our Mother took us away from him he lost a bit of himself that he would never get back. That he never got to be with us on special moments. That even after the death of his Brother, Mother and Father all within 5 years of each other had he ever been hurt so much. He has never recovered from it and had been depressed ever since. He couldn't be there for us, even though he wanted to more than anything in the world because of what my Mother did to him. The result was his only children resenting and even hating him for not being in their lives. But what choice did he have? None, he had zero choice in the matter. My Mother could take us anywhere in Australia and even though they shared custody he could have no say in it. And nether could I, being a child.
I think it's about time we started looking after the men in our lives ladies, and I certainly pledged to both my Father and Boyfriend that I would invest more of my time with them to mend the broken relationship. I promised to my partner that I would never, ever hurt him the way my Mother did to my Father.
I'm a young 24 year old woman and this year I have decided to make myself more aware of men's issues and stand up for the gorgeous men in my life.
Phi says:
WOW!! The year is going fast. 7th of February already (according to the open thread date above). Where did January go and did we win the one days?
DocBud says:
Peter Slipper has been summonsed;
Steve says:
So Slipper, Gillards choice for the Speaker, has been summoned to appear before a court on serious criminal charges.
The appalling judgement, at best, of this Prime Minister is again on full display.
Her man is a running sore on this parliament. Her judgement is a joke. Her decisions are demonstrably poor.
Not long to go now thank god.
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Patty M. Morton, Elizabethton, and Steve Markland, Elizabethton, were united in marriage during a western theme wedding on Saturday, Jan. 12, 2013, at the home of the bride's daughter, Melissa Buckles, 521 Jena Beth Drive, Elizabethton. Edward Doerr performed the 2 p.m., double-ring ceremony.
The bride is the daughter of the late Vester and Catherine Morton.
The groom is the son of Betty Markland, Stoney Creek, and the late Clarence Markland.
The bride wore a brown western dress and cowboy hat. She carried brown and tan lilies.
Attending the bride as matron of honor was her best friend, Debra Briggs.
Randy Morton, brother of the bride, served the groom as best man.
Following the ceremony a reception was held at the wedding site.
After a honeymoon in Myrtle Beach, the couple are residing in Elizabethton.


text:
BOISE -- With more than five days of triple digit temperatures in the forecast, Idaho Power is warning customers about increased power usage.
Company officials say extreme heat mixed with low water levels can make it difficult to keep up with high customer demands.
The caution will extend summer-long, due to what is expected to be a very hot and dry season.
Phil DeVol is the Resource Planning Leader for Idaho Power. DeVol says water levels in the Snake River Basin are at 50 percent of average.
"You have to go back to 2001 to see flows as low as we're seeing this year," said DeVol, who told us that's a concern Idaho Power has been addressing for months.
"We talk about projections on what kind of customer demands we anticipate seeing over the coming days, and as we're aware we're looking at a string of triple digit days coming up," said DeVol.
DeVol says when temperatures are in the triple digits, Idaho Power is forced to dip into storage reservoirs that are already low.
"It's critical that we draw from that reservoir only during those periods when demand is high and we store water in the reservoir during those off peaks periods and that's how we are very judiciously managing the storage in the reservoir this year," said DeVol.
Customers are encouraged to help take the strain off the system by keeping their homes cooler.
DeVol says you should keep your blinds closed, open your windows overnight, and use appliances like the washer and dryer during off peak hours, like the morning or late at night.
"So what we need to do is understand how that affects our demand and have our thermal plants ready to go and have our hydro plants ready to go," said DeVol.
DeVol says it looks like this summer will be worse than most since it's been so dry and we're already seeing such high temperatures.
He says anything you can do run your air conditioning less, helps the demand on the power grid.
While the Snake River Basin is lower than average, DeVol says the good news is that the Columbia Basin is at normal levels.
Click here for more energy savings tips, click HERE.


text:
Thursday, April 19, 2012
mama, why do you always lose your keys?
54 comments:
Hey lovely,ReplyDelete
Here's to variations - Bach or edible! You are so right that just a few really good basic techniques in the kitchen will take you far. I would be happy to eat that onion tart and a good salad any time:)
i look forward to feeding you both of them.Delete
- AnonymousApril 20, 2012 at 10:22 AM
"Hella ugly."ReplyDelete
Thank you.Replies
you're hella welcome.Delete
I once complained to my husband that I couldn't lose any weight. He said, "Don't worry. I've seen how you are with your keys. I am sure you'll lose the pounds soon enough."ReplyDeleteReplies
funny. if only.Delete
Great Recipes! The salad dressing especially will come in handy as I am going back to school full time :) I finally lost my key's for good, haven't been able to locate them in two weeks!! I'm assuming I ACTUALLY lost them. Happy Weekend!!ReplyDelete
i couldn't find my keys this very afternoon. so i wasn't able to go to the market. oh well. if only keys had a locator device like my phone. so exciting about school!ReplyDeleteReplies
Agreed! Key's should come with a gps locator ;) I'm very excited about school (going to be a midwife :)))), I'm actually moving to New York City for school! Any good tips ?Delete
a midwife? i want to be a midwife. damn. how beautiful. i'm a birth doula. certified many years ago! now i do believe i'm an expired doula! email me about nyc. my email is firstname.lastname@example.com
Doula's never expire ;-p Just sent you an email. Thanks!Delete
i once got my step-day "the key clapper" because he loses his keys. a lot. unfortunately, he did not really appreciate it very much. the next year, i got him a movie. went over much easier.ReplyDelete
there's a key clapper? omg. i need one.ReplyDelete
Are you going to publish a book any time soon?ReplyDeleteReplies
yes! yes! someday. that's the plan. thank you for asking. i'll let you know.Delete
I recently lost my sunglasses for 3 days under the blanket keeping our patch of carrot seeds wet and protected.ReplyDelete
Also, love the kick ass variation on a mom.
Just came across your blog, it is wonderful! These recipes look wonderful. I too don't believe in kids food and do very much believe in cooking with them. Although I am not a chef I am an occupational therapist (and mom) that helps kids with feeding difficulties. Your blog gives me new inspiration.ReplyDelete
If anyone is looking for help with improving your kid's eating check out my blog at www.YourKidsTable.com
Thank You!
will try both things and had an aha moment here...always love that. what was it? the bit about the strong vinegars...buying new vinegars today. i lose my favorite bra. all the time. and only figure it out once i'm topless. will work on this. the brain is full, you're right.ReplyDeleteReplies
so true. the keys, the favorite bra, the sunglasses, the phone. perpetually searching for them.Delete
mmm..something about the creaminess of those avocados paired with the crunchy lettuce and the bite of the dressing...that will happen. Tomorrow with dinner. Beautiful blog.ReplyDeleteReplies
thank you, robin. and yes, it is one of my favorite combinations. you're right that it's the combination of the creamy, the crunchy, and the bite that really makes it work.Delete
This is perfect- simple and beautiful. I'm always losing things too.ReplyDelete
I have a 17 year old Dash!ReplyDelete
the avocado "bowls" are simply stunning -- and look absolutely divine! i love it!ReplyDelete
So wonderful. Looking forward to making it and visiting your blog again! But please, do be careful about keeping anything with garlic and oil at room temperature. Once my husband and I infused an oil with garlic and used it after being unrefrigerated a few days,and we got very, very sick. http://www.bchu.org/index.php?option=com_content&task=view&id=1092&Itemid=468ReplyDelete
- AnonymousJune 25, 2012 at 8:59 PM
Your blog is fucking awesome. Write a book so I can give it for gifts!ReplyDeleteReplies
oh my god. thank you.Delete
First time on your blog...children grown...but can I ever relate to your recipes and writing style!! Thanks a million!!!ReplyDelete
First time visit to your blog, I saw the avocado salad on Ex-presso blog and had to come check it out! So creative, a lovely post format and beautiful photographs! Can't wait to try out that salad dressing!ReplyDelete
- AnonymousAugust 10, 2012 at 8:08 AM
I love your blog and recipes...just not your potty mouth.ReplyDelete
Potty mouth? Ha... That is like asking Emeril to cook without his essence.. Keep it real, that's why people like your work!ReplyDeleteReplies
it's how i speak. it's how i write. that's just the way it is!Delete
- AnonymousJanuary 4, 2013 at 6:39 AM
I agree with no potty mouth. There are so many great words in the English language that are descriptive for good cooking. But, that would take a little time and 'food for thought'. It devalues your work as far as I'm concerned.ReplyDelete
I think we could do without the swearing in this recipe suggestions. Seriously....it definitely directs people away from your entries!ReplyDelete
- AnonymousMarch 8, 2013 at 10:56 PM
I disagree about the "potty mouth"... it made me want to read more , as I can feel the emotion in the writing, a real person who I can identify with has written this... thank you for not censoring out the realness just so people wont be offended. I will be trying the salad for sure!ReplyDelete
- Cecilia StauntonMarch 12, 2013 at 7:33 AM
"Fucking" is one of the best words in the English language. Well placed and keeping it real. Love this blog but trying to figure out how to print without using all my color cartridge up. Any chance there is a way to just print the recipe?? I spend more time cooking and gardening then on a computer...ReplyDelete
I think I love your blog spot page already because of all the healthy salad recipe you had posted. Going to add your link on my bookmark.ReplyDelete
- AnonymousApril 27, 2013 at 6:05 PM
Divine dressing recipe, the whole family loved it! Made it for the avocado salad which was so perfect, I am now craving to try it on some fresh tomatoes and mozzarella.ReplyDelete
I love the variations, looking forward to reading more of your blog, thank you.
And p.s. your writing style is sexy and fun, I hope you always ignore these lame-o naysayers!
TOTAL yum. want to eat NOW. thank you for posting!ReplyDelete
Gorgeous salad and tart!!ReplyDelete
- LorrieJune 26, 2013 at 7:31 AM
I can't wait to try this dressing, with all of it's many incarnations! I seem to be incapable of going anywhere without bringing home some of the local, so there's lots of vinegars at my house to play with. Thanks!ReplyDelete
- AnonymousJuly 16, 2013 at 5:10 PM
Cecilia may like your language but it turns me off. Won't be back.ReplyDelete
- AnonymousSeptember 22, 2013 at 4:34 AM
Best blog I have ever found. I love it. I want you to be my new bff. It's great that you drop the f bomb, as in real life. My real life anyway. And I love that you speak to your kid like he is a person, not a short dimwit. Kids are people without as much life experience as us and getting them ready to fully participate in the world is hard, hard work. Seems like you've got a handle on it. I am now going to the kitchen. That salad is on tonight's menu; much less fussy than my usual, although I do make a similar mustard vinaigrette. That is something I see no point in not making since it takes seconds, not minutes, to throw together. I even buy anchovy paste to really keep it simple.ReplyDelete
What is in your salad besides Avacado/ Romaine lettuce? Recipe please :)ReplyDelete
Someone asked me this question over the weekend and I must have really raised an eyebrow or something, because the person went on toReplyDelete
Buy Yacon Syrup United Kingdom say she really just wanted to have the BEST wedding possible and how do you go about getting it?Someone asked me this question over the weekend and I must have really raised an eyebrow or something,because the person went on to say she really just wanted to have the BEST wedding possible and how do you go about getting it?
تسليك مجارى بالرياضReplyDelete
تنظيف بيارات بالرياض
افضل شركة كشف تسربات
كشف تسرب المياه الكترونيا
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شركة تنظيفReplyDelete
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شركة عزل خزانات بالرياضReplyDelete
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the first F-bomb actually made me laugh out loud...i cannot go buy romaine and avocados soon enough....smashed anchovy...OMG i love the whole idea...it is swirling around as i type and i cannot wait to eat it...ReplyDelete
شركة تنظيف فلل بالرياضReplyDelete
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text:
|Many thanks March 2014 donors; special to Darren Duncan. April 2014 donations open; need minimum total $100. Let's exceed that.
Donate here. Donating gifts yourself and CZ.
Changes related to "Kennel club"
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This is a list of changes made recently to pages linked from a specified page (or to members of a specified category).Pages on your watchlist are bold.
Legend: N - new page, m - minor edit, b - bot edit.


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Lake Shore Cryotronics, Inc. Nov 27, 2013
Columbus, Ohio (November 27, 2013)
FluidFM Webinar: Advancing Single Cell Manipulation and Analysis
Nanosurf AG Sep 5, 2013
Fluid Force Microscopy (FluidFM) combines the unique possibilities of nanofluidics with the positional accuracy and force sensitivity of the atomic force microscope...
Park Systems Introduces Park NX-HDM
Park Systems Jul 4, 2013
Fully Automated Automatic Defect Review and Sub-Angstrom Surface Roughness for Hard Disk Media and Semiconductor Substrates.
Lake Shore to Exhibit Materials Characterization Systems at SEMICON West 2013
Lake Shore Cryotronics, Inc. Jul 3, 2013
Columbus, OH (July 2, 2013) – Lake Shore Cryotronics will highlight its range of industry-leading materials characterization solutions...
New glove box mounted coating system from Quorum Technologies
Quorum Technologies May 10, 2013
Quorum Technologies is pleased to introduce the Q150GB – a fully automatic, modular glove box version of the market leading Q150T ES bench top turbomolecular-pumped coating system.
3D Optofan Series
Optoscribe Apr 8, 2014
3D waveguides designed to simply connection and increase the amount of data transferred between singlemode Fibers (SMF), Multimode fibers (MMF) and Multicore fibers (MCF)


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3X3: Three Ballets by Three Choreographers
KETUBAH - Julia Adam
IN YOUR EYES - Viktor Plotnikov
SMOKE 'N ROSES - Dwight Rhoden
The date is set for one of Pittsburgh's Top Ten Parties of the year: Pittsburgh Ballet Theatre's annual Pointe in Time Ball. On November 1, 2014, we will kick off a major milestone in PBT history: Our 45th season.
Photos by: Aimee DiAndrea
In 40 years with Pittsburgh Ballet Theatre, Janet Marie Groom's career spans more than 500 tutus, 200 productions and 800 performances of The Nutcracker.
Photos by Rick Sofranko
PBT presented its mixed-repertoire production Unspoken in March 2013 at the August Wilson Center. Photos by Rich Sofranko.
Peek into the studio as PBT company dancers prepare for Unspoken, onstage March 8-17 at the August Wilson Center.
Photos by Rich Sofranko
2900 Liberty Avenue, Pittsburgh, PA 15201-1500


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POCKET HOSE™ expands to full length ... contracts for easy storage! Expandable garden hose has an accordion design that automatically gro-o-ows in length to 25 ft., 50 ft., 75 ft. or 100 ft. when water is turned on; shrinks back to original size when you are done. Lightweight and easy to handle; can be stored anywhere. Best of all, it never twists, tangles or kinks. Fits all standard spigots and nozzles.
"I love my POCKET HOSE...no more fighting to unwind and untwist my bulky hose. As a senior with arthritis, I can once again clean my patio, water plants and take care of the things I was beginning to have a difficult time with. After I purchase another one for my front yard, I plan to buy them for gifts for a few people I know will enjoy them as much as I do!" - Customer in Surprize, AZ
|Item Number
|Product Description
|Pocket Hose™ (25 ft.)
|Item Available
|Pocket Hose? (75 ft.)
|Item Available
|Pocket Hose? (100 ft.)
|Item Available


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Free shipping applies to all domestic orders. Orders are processed and shipped during regular business hours (Monday through Friday 8:00 am to 5:00 pm EST, excluding holidays).
Save an extra 20% off your entire order with coupon code: Bloom20
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Code expires Wednesday, April 30th 2014
Outdoor dining chair cushion to fit standard outdoor furniture. Seat cushion measures 4 x 19 x 19. Circle tufted with string ties to fasten securely to your outdoor furniture.