ABSTRACT The chemical composition of the essential oil of Pectis elongata from Martinique was analyzed for the first time by GC/MS. The major components were found to be neral (15.65–27.47%), geranial (24.56–40.15%) and geranic acid (5.00–19.88%), the levels of which depended on the state of maturity of the plant and its collection site. The biostatic activity of the oil and two solvent extracts from the leaves was evaluated against five bacterial and six fungal strains. The oil showed higher activity than the extracts towards both the bacterial and fungal strains with an MIC of 0.5 mg/mL when screened against Staphylococcus aureus, E. coli and Mycobacterium smegmatis.


Materials Properties.- Computer Simulation Studies in Condensed Matter Physics: An Introduction.- Accelerated Molecular-Dynamics Simulation of Thin Film Growth.- Simulating the Interaction of High Intensity Optical Pulses with Nanostructured Optical Devices.- Crack Motion Revisited.- Deconstructing the Structural Convergence of the (110) Surface of Rutile TiO2.- New Models, Methods and Perspectives.- Ensemble Optimization Techniques for the Simulation of Slowly Equilibrating Systems.- The Avogadro Challenge.- Visualizing Nanodiamond and Nanotubes with AViz.- Molecular Dynamics Simulations for Anisotropic Systems.- Event-by-event Simulation of EPR-Bohm Experiments.- Non-Equilibrium and Dynamic Behavior.- Fisher Waves and the Velocity of Front Propagation in a Two-Species Invasion Model with Preemptive Competition.- Dynamics and Thermal Structure of Gas-Liquid Phase Interface.- Rate Constant in Far-from-Equilibrium Open Systems.- First-order Reversal Curve Analysis of Kinetic Monte Carlo Simulations of First- and Second-order Phase Transitions.- Magnetic Systems.- Vortex Fluctuation and Magnetic Friction.- Simulational Study on the Linear Response for Huge Hamiltonians: Temperature Dependence of the ESR of a Nanomagnet.- Attraction-limited Cluster-Cluster Aggregation of Ising Dipolar Particles.- Biological and Soft Condensed Matter.- Simulational Study of the Multiple States in Hippocampal Slices.- Dissipative Particle Dynamics of Self-Assembled Multi-Component Lipid Membranes.- Solvent-Free Lipid-Bilayer Simulations: From Physics to Biology.- Computer Simulation of Models for Confined Two-Dimensional Colloidal Crystals: Evidence for the Lack of Positional Long Range Order.


Large power transformers used to transmit electrical energy from the power plants to the grid are the units where significant amounts of heat are generated due to ohmic and core losses. Consequently, efficient heat dissipation must be ensured. Nowadays, most of the large power transformers are cooled in air-natural, air-forced, or oil-directed air-forced regimes with dielectric oils used for the active elements cooling to prevent their overheating. Unfortunately, commonly used mineral oils are characterised by low biodegradability, environmental contamination, and hazards in case of leakage and low fire point. The sustainability of mineral oil production, utilisation, and disposal is questioned nowadays due to limited natural resources and environment degradation. Therefore, biodegradable synthetic and natural ester oils are recognised as a promising alternative for the application of electrical devices cooling. This study presents a numerical investigation of 8.5 MVA disk-type power transformer cooling using biodegradable ester oil and conventional mineral oil as a reference. Operating conditions were defined for a wide range of ambient temperatures from −5.8° C to 32.0° C, which are characteristic for different seasons in Polish and Argentinian climate zones. For a detailed modelling of the entire power transformer, a computational strategy was introduced to develop several numerical models of selected parts of the transformer and to couple them using properly defined boundary conditions. Consequently, a detailed analysis of the power loss, oil flow, and the temperature level in different parts of the unit can be performed with a satisfying computational effort. In particular, the velocity field within the entire transformer tank and inside the windings oil ducts is evaluated and the local temperature values including the hotspot temperature can be determined. According to the results, the average windings temperatures are higher from 2 K to 9 K when the ester oil is used for the cooling of the analysed device. Moreover, the hotspot temperatures increased by up to 9 K and 18 K in low voltage and high voltage windings, respectively. The analysis of the fluid flow suggests that the oil ducts require modification if the mineral oils would be replaced by esters in the analysed construction.


The International Space Station (ISS) being assembled on orbit is using 120 V DC electric power systems and one of good example of the large-scale space power systems. In order to prevent the fault propagation, provide protection against overload and fault, and isolate the faulty load and equipment in the large-scale space power systems using high voltage direct current, a solid state type of power switching device which has the current limiting function must be applied to the switching gear for the electric power management and control system. A solid state remote power controller (RPC) has been developed and assembled for the Japanese Experimental Module (JEM) electric power system. An RPC has a unique capability to limit short term over-current through the power device (Power MOSFET) operation in the active region. In this paper, the approach of the developing the CLS (current limiting switch), which is the very basic function model of the RPC, will be described for the large-scale space power systems. The evaluation for the CLS by experiment and analysis will be shown in this paper. The experiment result of the CLS in the network coordination with upstream and downstream will be also shown in this paper.


''Beyond the Case: Comparative Ethnography during COVID-19 and Beyond.'' December 21, 2020. Hosted by the Institute for the Study of Societal Issues at the University of California-Berkeley. https://www.youtube .com/watch?v=yf9nhUZL04o. Jerolmack, Colin, and Shamus Khan, eds. 2017. Approaches to Ethnography: Analysis and Representation in Participant Observation. New York: Oxford University Press.


history of Great Britain's foreign relations requires an understanding of financial relationships, owing to Britain's special role in the world-wide economic system: sterling provided the principal means of exchange in international trade since the nineteenth century. In dealing with both foreign countries and its empire, therefore, Britain had accepted the role of the world's banker and the obligation it entailed to maintain large reserves for the settlement of debts in order to secure the stability of sterling.1 Britain's cosmopolitan approach to trade and finance, derived from a nineteenth-century preference for free trade, was replaced in the 1930s by a system of imperial preferences that limited free trade to the colonies and other countries within an emerging sterling bloc. On the outbreak of the Second World War, the convertibility of sterling was suspended: free movement of goods and payments was confined to the so-called sterling area, and discriminatory measures were implemented against the rest of the world. These allowed the British to manage transactions with the dollar area through a pooling system, and they provided a mechanism whereby other members of the sterling area accumulated sterling balances whenever their exports were not balanced (or requited) by imports. The balances acted as a form of credit that helped Britain to support its balance of payments. However, they also represented claims on Britain that might one day have to be met. Britain had to find ways to limit this risk while enhancing the performance of the sterling area. Such financial considerations were an important influence in the 1940s and 1950s on Britain's relations with the United States, Commonwealth members of the sterling area, and Europe. The United States, as Britain's principal creditor, had to be persuaded to act predictably, given Britain's agreement at Bretton Woods in 1944 to move towards convertibility, but


erberine(Ber 5,10、20mg·kg-1,ip)significantly prolonged the survial time of
micesubjected to cerebral ischemia by the occlusion of thebilateral carotid arteries. The
mortality of the mice sub-jected to reperfuSion after cerebral ischemia was re-duced by Ber
After acute incomplete cerebral ischemiain rats induced by hypotension coupled
withhypoperfusion for 30 min, Ber (40 mg·kg -1 ip) mightmarkedly increase the activities of
superoxidedismutase and decrease the concentration ofmalndialdehyde in plasma,as well as
in hipocampusand cortex of the brain.in the model of local cerebralinfarction of rat produced by
middle cerebral arteryocclusion,Ber(20, 40 mg·kg-1,ip before operation)decreased the infarct
size and ameliorated neurologicdeficits,improved electroencephalogram changes in 2h
occ1usion of rats.


Amorphous and nanocrystalline Fe-based alloys are becoming increasingly interesting for more efficient energy distribution systems and/or for miniaturized sensors and related devices.


A detailed hydrochemical analysis was carried out on groundwater samples collected from the barrier-spit system of the Chilika lagoon on the east coast of India. The water quality in both pre- and post-monsoon periods and the interactions with the sea water throughout the year were characterized. The concentrations of major ions were measured quantitatively. Results show that during the post-monsoon season, the salinity level, as indicated from the TDS values, is lower, and groundwater contains higher concentrations of Ca and HCO 3 ions as compared to other major ions. In the pre-monsoon season, the TDS values increased to a high value, with all the major ions showing higher values. The high values indicate seawater encroachment into the fresh water aquifer, which was confirmed by ionic ratios. The concentration of TDS, Na and Cl in the post-monsoon groundwater was within permissible drinking water limits. The concentrations during the pre-monsoon season were not within permissible limits. It is recommended that during this period, pumping from bore wells be minimized to control seawater intrusion.


The paper presents a dual fault-tolerant system and its process of synchronization in order to make two computers work in phase.The synchronization is based on task,and realized with the cooperation of dual-computer controller and outer memory.When both computers are well,the applications in two computers work disorderly,but the information of synchronization is stored in outer memory,guaranteeing the correctness of the system outcome.Simple criterions of applications make the system more flexible,with high performance of single computer and high reliability of the whole system reserved.Corresponding solutions for key points such as the switch between two computers are put forward.


Abstract Noise is generally considered as nuisance in engineering. Hence engineers routinely attempt to filter out noise. But quite remarkably a counter intuitive phenomenon was found in 1980s that changed the perception of noise, giving birth to a phenomenon called Stochastic resonance (SR). In this paper, we review various phenomena that are benefited by noise. Quite obviously, we extend those ideas to Control Systems design. We provide 3 examples: a randomized algorithm for a linear state feedback control law, (ii) minimizing limit cycles in nonlinear systems, and (iii) antilock braking system (ABS) design. Finally, we present some of our arguments in favour of stochastic resonance as a potential tool for system design in a broader perspective.


ABSTRAK Hidayati, Laely. 2017. Effect of Collaborative Tasks on the EFL Students' Writing Performance. Thesis, Graduate Program in English Language Education, Universitas Negeri Malang. Advisors: (1) Prof. Bambang Yudi Cahyono, Ph.D. (II) Dr. Furaidah, M.A. Keywords: effect, collaborative writing, pair work, small group work, writing performance Collaborative writing has been widely applied in English language teaching due to its substantial contribution to overcome students' problems in writing. It gives the students opportunities to work together to produce a joint text. This research was set out to investigate the effect of collaborative writing and compare the students' writing performance who worked in pairs and small groups. Employing quasi experimental design, this study involved the eleventh grade students of SMAN 2 Malang. The experimental group consisted of 28 students. While there were 27 students in control group. The main source of data analysis was from writing posttest specifically hortatory exposition text. Then, MANOVA (Multivariate Analysis of Variance) was used to test the hypotheses since the statistical assumption has been fulfilled. MANOVA was employed to assess students' writing based on each aspect of writing. This study revealed that there was a significant difference in writing performance of the students taught using collaborative writing and those taught using individual writing (Sig. .005 ≤ Sig. .05). In other words, the students who were taught using collaborative writing had better writing performance specifically in organization and vocabulary compared to those who were taught using individual writing. Furthermore, this study also indicated that there was no significant difference in writing performance of the students taught using collaborative pair work and those taught using collaborative small group work (Sig. .141 ≥ Sig. .05). Neither pair work nor small group work was better. In conclusion, collaborative writing gave better result in students' writing specifically in organization and vocabulary aspect regardless of working in pairs or small groups. Working in small group gave better result in terms of content, organization, grammar and vocabulary but still the scores differences could not make group work significantly better than pair works. Pertaining to the result of this study, future researchers are suggested comparing students' reactions to a variety of writing tasks involving different level of students. Beside grouping the students into pairs and small groups, future researchers can consider other attributive factors such as gender, personality and number of group members. Furthermore, the collaborative process can also involve online based platforms such as Tumblr or Google Docs. Normal 0 false false false IN X-NONE X-NONE /* Style Definitions */
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Good relationships between computational image analysis and radiological physics have been constructed for increasing the accuracy of medical diagnostic imaging and radiation therapy in radiological physics. Computational image analysis has been established based on applied mathematics, physics, and engineering. This review paper will introduce how computational image analysis is useful in radiation therapy with respect to radiological physics.


Cophase traction power system has high potential to be power supply for high-speed railway. However, the dc operation voltage of conventional power quality compensation device within, such as railway power quality conditioner, is high and may limit its application and development. The hybrid power quality conditioner (HPQC), in which a capacitive coupled LC structure is added, is thus proposed for lower operation voltage. However, there is less investigation and study on the HPQC parameter design for minimum operation voltage when harmonic compensation is concerned. In this paper, the HPQC design for minimum dc operation voltage under comprehensive fundamental and harmonic compensation is being proposed and introduced. Analysis and case study are also performed to show the advantage of the proposed HPQC design. Simulation and laboratory-scaled experimental results are presented to show effective reduction in dc operation voltage using the proposed HPQC design. Through the simulation and experimental case study and verification, there is a reduction of 15% in operation voltage using the proposed hybrid LC structure design compared with the conventional design. The proposed design does not add much additional cost and can also reduce the coupling inductance value. Similar analysis procedure may be also applied to other LC hybrid-structured active power compensators.


The conventional Kalman filtering algorithm requires the definition of a dynamic and stochastic model, and errors of low cost MEMS-IMU are likely to vary temporally. So the conventional Kalman filter exists limitation in MEMS-IMU/GPS integrated navigation. This paper presented the use of multiple model adaptive estimation(MMAE) where multiple Kalman filters were run in parallel using different dynamic or stochastic models in MEMS-IMU/GPS integrated navigation. And the modified multiple model Kalman filter was used in order to solve the limitation of multiple model adaptive estimation(MMAE). Using static tests, the algorithm designed was validated. The test results show that the modified multiple model Kalman filter can improve performance of MEMS-IMU/GPS integrated navigation system, compared to the conventional Kalman filtering algorithm. And using the designed algorithm, the positioning accuracy is better than 5m and velocity accuracy is better than 0.1m/ s2, and the attitude errors are less than 0.5 degrees on the static condition.


Modern concepts of an estimation of interaction of the state and business are considered. The conclusion is drawn on perspectivity of development of the infrastructural approach. The basic threats to development of a market infrastructure of the Russian economy are revealed. Direction of neutralization of these threats are offered.


To resolve the problem of data association between region and county level power-dispatching, the method based on REST web service is proposed. According to needs of power-dispatching data association, as well as the characteristics of security and real-time requirement, the REST basic concepts, objectives and design constraints are studied first, then the project of data association between two power-dispatching levels based on REST web service is designed and realized. And the practice showed that this method is feasible and meet the requirement of power-dispatching.


Minuzzi thoroughly explores the vicissitudes of the 1617 'official' Pharmacopaea that was immediately withdrawn from sale after the powerful Collegio degli Speziali's veto. Special attention is paid to the numerous private Venetian pharmacopoeias, including the grandiose Nuovo, et universale theatro farmaceutico (1667) produced by the Spezieria allo Struzzo and aiming at providing a summa of all medicines, both Galenic and chemical. The chapter on botany contains fresh information about Johannes Behm (c.1640–1731) – Italianized as Giovanni Beni – a little-known German chemist and botanist who settled in Venice in 1669, practised medicine, prepared chemical remedies and corresponded with eminent botanists from many European countries, besides building up a rich natural-history collection. The third part of the book is devoted to the domestic production of medicines, containing a number of case studies, including one on Colochi-Olivieri, a remarkably successful family who managed to sell the HealthOffice their medical secret to cure the plague.Making use of fresh archival evidence, Minuzzi sheds light on a number of distillers, barbers, herb sellers, dyers, artisans, clergymen, lay practitioners and women, who played a relevant part in the production and trade of 'secret medicaments'. Though the licences granted to women were predictably a small part of the number of licences, female medical practitioners were not on the margins of the Venetian medical world; they often interfaced household medicine with the emerging structures of public health. The book ends with appendices containing inventories of pharmacies, pictures fromVenetian pharmacopoeias and diagrams related to the licensing of the sellers of medical secrets. Drawing on a wide range of primary sources and on rich, largely untapped, archival resources, Sul filo dei segretimarks a substantial contribution to our knowledge of the medical world of early modern Venice. ANTONIO CLERICUZIO University Roma Tre


With the purpose of studying the fermentative conservation of sweet potato foliage, laboratory silos were prepared' each containing 4 kg of chopped foliage, allocated to 25 treatments resulting from the factorial combination of 5 levels of sweet potato roots (0, 3, 6, 9 and 12% of the ensiled material, on fresh basis) and 5 levels of urea (0, 0.4, 0.8. 1.2 and 1.6% of the material, fresh basis). Duplicate silos were used thus resulting in a total of 50 units. The addition of urea caused a linear increment in pH and a quadratic increase in DM losses by putrefaction. However, no definite effects were detected with regard to acetic, butyric and lactic acids. The DM in vitro digestibility remained relatively constant around an overall average of 60.3%. The addition of roots had an acidifying effect which became more marked as the level of urea increased; however the extent of this effect was very modest when compared to the alkaline effect imparted by urea. There were no noticeable effects of root additions upon DM losses by putrefaction and lactic acid concentration. In general, the concentrations of acetic and butyric acids increased with additions of roots. The values for butyric acid changed from 1.07%, to 3.46% on dry basis, when the level of roots varied from 0 to 121, respectively. The in vitro DM digestibility of the ensiled material improved slightly when roots were added. The silages that contained no additives showed excellent characteristics; their pH values averaged 3.9 and the acid concentrations were 3.49%, 0.68%, and 5.21% for acetic, butyric and lactic acids, respectively. Losses of DM by putrefaction were low (11.6%) in these silages. In view of the results obtained when no additives were used and when urea or roots were added, it is concluded that silages of excellent quality can be obtained from sweet potato foliage as long as no additives, such as urea or roots, are used.


Identify the sleep support member before the identified sleep support member is provided to the consumer, to determine the tested comfort / support value for the identified sleep support member, the tested comfort / support value, determining whether within a predetermined allowable range of the target comfort / support value for the identified sleep support member, the method of testing a sleep support member. A specific unit for identifying the sleep support member before the identified sleep support member is provided to the consumer, and comfort / support testing unit for determining the tested comfort / support value for the identified sleep support member , tested comfort / support value, the test device of the sleep support member having a an analysis unit for determining is within a predetermined tolerance of the target comfort / support value for the identified sleep support member.


This paper discusses the expansion of the Issue Correlates of War (ICOW) research project from its initial focus on territorial claims through expansion to river and maritime claims, and ultimately to a new data set on identity claims. It begins by discussing the nature of each of the four data sets, indicating how they are defined and how the data sets differ. While data collection on identity claims is not yet complete, the paper concludes by discussing what this new data set can contribute to the field of conflict research, as well as laying out future directions for ICOW research.


In this paper, we propose a specific structure in the star graph for local diagnosis under the PMC model. We design an adaptive local diagnosis algorithm for a star graph Sn. We prove that Sn is (n − 1)-diagnosable with our proposed algorithm under the PMC model. Moreover, with our algorithm, a diagnosis is completed in three test rounds.


This paper introduces the work of invention of Lightning Recording System (LRS) and the locating method of lightning stroke point on 500kV AC transmission lines with LRS. The LRS is designed to record the waveform of lightning current on the grounding line and send the data to the station via General Packet Radio Service (GPRS). With the division of current across multiple paths at the tower junction while spreading along the wire, the current on the grounding line at each tower is different. The position of lightning stroke point can be estimated by contrasting the value of current peak on the grounding line recorded by LRS sensors on different towers or analyzing the front time of the recorded waveform.


【Objective】 Rational utilization of soil microbial for improving soil environment is helpful to promote plant yield and quality. The adaptation of cherry root is bad, so it is sensitive to the change of soil environment. The objective of the experiment is to discuss the mechanisms of Cerasus sachalinensis(Fr.Schu) seedlings responding to soil sterilization and inoculation of Pseudomonas fluorescens, thus providing an academic and practical basis for regulating the rhizosphere soil.【Method】In order to find the influence of inoculation P. fluorescens on plant root function, C. sachalinensis(Fr.Schu) seedlings were used as materials to measure the correlative indexes of root respiration metabolism.【Result】Compared with soil sterilization, glycolysis, tricarboxylic acid cycle, and cytochrome oxidase pathways were also the dominant respiratory pathways from 5 d to 50 d after C. sachalanensis seedlings were subjected to CK and SS+Pseu treatments. On 5th d, there was no significant difference in total respiration rate of the roots between SS+Pseu treatment and CK, however, on 20 and 35 th d, in SS+Pseu treatment, the total respiration rate of the roots was lower than that in the CK, while the total respiration rate of the roots in the SS+Pseu treatment was higher than that in CK on 50 th d. On 5th d, the activities of PK, MDH, G-6-PDH, SDH were significantly increased in the SS+Pseu treatment, however, the activity of PFK was significantly decreased. On 20 th d, the activity of PK was significantly increased in the SS+Pseu treatment, however, the activities of PFK and G-6-PDH were significantly decreased. On 35 th d the, activity of PFK was increased by 127.0%, On 50 th d the activity of G-6-PDH was increased by two times. Though, there were some differences between CK and SS+Pseu treatment, however, these differences were not significant. In SS+Pseu treatment the stem diameter and leaves number were significantly increased by 9.3% and 16.7%. Inoculation with P. fluorescens was helpful to plant growth.【Conclusion】Inoculation with P. fluorescens could influence plant growth and root function. In general, 20 d after the end of continuous inoculation(six times) with the bacterial liquid whose OD value was 0.4 could change the rate of respiration pathways, key enzyme activities via influence the function of roots, and then promoted plant growth.


CADE has recently analyzed two international mergers with intense cooperation with DG-Competition. In fact, these two cases reflect the advances brought by new Competition Law. In the previous…


A Dissertation submitted in accordance with the requirement for the degree of Masters in Commerce in the Faculty of Commerce, Administration and Law in the Department of Business Management at University of Zululand, South Africa, 2013.


This paper describes an approach to develop a computer-aided translation (CAT) platform dedicated to the derivation of translation examples in an attempt to maximise past translation reuse as well as terminology and style consistency in the translation of specific types of text. Such tools have come in the bibliography under the term Translation Memory (TM) tools. We first briefly outline the setting in which the development effort was undertaken, and then we give a description of the architecture of the platform. Current applications building on the technology underlying CAT and translation example derivation are also briefly discussed in the context of multilingual information retrieval.


To the Editor:

The SSYLVIA trial's results clearly add to the nascent body of literature evaluating vertebral artery stenting.1 Even in the absence of 'gold standard' surgical procedures such as endarterectomy for the treatment for vertebral artery disease, the recognition of vertebral artery disease has not progressed like its carotid artery counterpart. Rocha-Singh insightfully attributed this to the nonspecific symptoms …


The effect of collisions on harmonic generation in an ionized gas slab through which an electromagnetic wave is passing is considered. The gas is assumed to be slightly ionized with electron‐neutral molecule collisions dominating. An approximate distribution function is assumed which contains five undetermined parameters. Boltzmann's transport equation is used to obtain the appropriate kinetic equations governing the behavior of these parameters. The kinetic equations are coupled to Maxwell's equations and a Fourier solution in time is used. The ionized gas slab is stratified into a series of individually homogeneous laminae and the equations are solved. The first harmonic transmitted and third harmonic generated power are calculated and plotted versus input power for several collision cross sections.


Summary A noticeably increased intensity of migration becomes a very important issue with regard to economic, socio-cultural and political matters. Broader flow of people results in the occurrence of numerous threats, but also provides opportunities and benefits for both the participants of migration flows, and the areas to which the flow is directed. An important role in this process is played by the students, who con stitute a special category of immigrants. The article contains a socio-economic characteristics of foreign students from countries of the former CIS, with the emphasis on their reasons for immigration, organizing their new life abroad, life plans and in particular their economic activity. The core purpose of the article is to identify the mechanisms of adaptation of foreign students as a specific category of immigrants to functioning in the new socioeconomic environment. The article, in addition to its cognitive merit, also has a practical purpose. The problems and obstacles faced by foreign students in Poland form a basis for general recommendations for actions aimed at improving the conditions of functioning of foreign students in the new realities.


Background Plasmodium falciparum resistance to sulphadoxine-pyrimethamine (SP) threatens the efficacy of intermittent preventive treatment (IPTp) for malaria in pregnancy in Africa. We conducted a metaanalysis to assess the impact of SP resistance on IPTp-SP effectiveness. Methods We searched databases (1990 to March-01-2018) for clinical studies (aggregated data) or surveys (individual-participant data) containing information on low birthweight (LBW, primary outcome) and malaria by IPTp-SP dose, and for studies reporting SP-resistance molecular markers. We performed random-effects meta-analysis (clinical studies) or multivariate log-binomial regression (surveys) to obtain summarized dose-response data (Relative-Risk-Reduction:RRR) and multivariate metaregression to explore modifying effects of SP-resistance (dhps substitutions A437G, K540E, A581G). Findings Of 1097 records, 57 studies were included in the aggregated-data meta-analysis (59,457 births). The RRR for LBW declined with increasing prevalence of Pfdhps-K540E (P-trend=0.0060) but not with Pfdhps-A437G (P-trend=0.35). The RRR in areas of high (Pfdhps-K540E >90%, n=11), moderate (Central/West Africa:Pfdhps-A437G≥90% or East/southern Africa:Pfdhps-K540E 30-90%, n=16) and low SP-resistances (n=30) were 7% (95% CI 0-13), 21% (14-29) and 27% (21-33) respectively (Ptrend=0.0054, I2=69.5%). In the individual-participant analysis of 13 surveys (42,394 births), IPTp-SP was associated with reduced LBW in areas with Pfdhps-K540E>90% & Pfdhps-A581G<10% (RRR=10%, 7-12), but not those with Pfdhps-A581G>=10% (pooled Pfdhps-A581G prevalence:37%, range 29-46) (RRR=0.5%, -16-14, n=3). Interpretation The effectiveness of IPTp-SP is reduced in areas with high SP-resistance, but IPTp-SP remains associated with reduced LBW in areas where Pfdhps-K540E prevalence exceeds 90%. IPTp-SP is not effective in areas with ≥37% prevalence of the highly-resistant sextuple Pfdhps-A581G-containing genotype. Funding CDC, Bill-and-Melinda Gates Foundation, EDCTP van Eijk-IPTpMeta-29Oct18 3 Research in context Evidence before this study We searched four databases (the Malaria in Pregnancy Library, PubMed, Web of Science, and Scopus) for studies in sub-Saharan Africa of the ecological relationship between molecular markers of SP resistance and the effectiveness of IPTp with SP on LBW, preterm birth, maternal malaria infection and maternal anaemia published in the English language up to March 01, 2018. The following search terms were used: "Malaria AND pregnan* AND (intermittent OR IPT) AND Review". Four studies, including one prospective multi-country study in eight sites, two meta-analyses and one modelling study were identified. The prospective study which included a 42-day therapeutic efficacy study, showed a strong ecological correlation between the prevalence of molecular markers for SP resistance and the ability of SP to clear existing infections or the duration of post-treatment prophylaxis in women receiving IPTp-SP. There was no clear trend between resistance and the effectiveness of SP to reduce LBW, maternal anaemia or Plasmodium infections, but none of the studies were conducted in areas where the highly resistant sextuple mutant parasites were common. One of the two meta-analyses compared, among other regimens, the effect of IPTp-SP against no intervention or placebo; no protective effect of IPTp-SP against LBW was detected in areas with >50% Pfdhps-K540E mutation prevalence, but this analysis was based on three studies, only one of which was in areas where the sextuple mutant parasites were common. By contrast, the other meta-analysis included nine studies and found no evidence for reduced effectiveness in areas with high SP resistance; the small number of studies in these highly resistant areas (n=3) was a limiting factor. The modelling study estimated the number of pregnancies occurring in the different SP resistance strata in Africa based on the Pfdhps-K540E and A581G mutations. It also modelled the relationship between the effectiveness of IPTp-SP on LBW at differing levels of resistance using an existing model of parity-dependent immunity to placental malaria combined with data from the multi-country observational study that assessed the ability of SP to clear existing infections among women receiving IPTp-SP. It did not study the relationship between the impact of SP resistance and the effectiveness of SP directly but did suggest that, even accounting for SP resistance, extending IPTp-SP to all women attending ANC would have a sizeable and cost-effective impact on maternal and infant health. This inference was valid in almost all malaria-endemic settings in sub-Saharan Africa with low to high resistance; the single exception was the highly resistant areas where parasites with the sextuple mutant genotypes are common. Added value of this study This is the most comprehensive study of the impact of SP resistance on the effectiveness of IPTp involving 57 studies, 13 surveys, and more than 100,000 births. The results of the aggregated data meta-analysis indicate substantial heterogeneity in effect size between studies, which may explain both the contradictory findings between the two previous smaller reviews and the ongoing controversy about the continued use of IPTp with SP in areas of high resistance We report for the first time a clear trend towards reduced effectiveness of IPTp-SP on LBW and P. falciparum infection with increasing prevalence of molecular SP resistance markers. A beneficial association of SP protection against LBW remains evident even in areas of high resistance where parasites with the quintuple Pfdhfr/Pfdhps mutant haplotype are essentially fixed. However, three observational cohort studies published elsewhere suggest that these beneficial effects are no longer apparent in individual women infected with the highly-resistant sextuple mutant parasites additionally carrying the quintuple mutant haplotype and the Pfdhps-A581G mutation. van Eijk-IPTpMeta-29Oct18 4 Implications of the available evidence The overall available evidence to date suggests that the effect of IPTp-SP in reducing malaria infection, anaemia, and LBW declines as resistance increases, but overall the effect of SP on decreasing LBW is surprisingly resilient. Use of IPTp-SP remains associated with lower risks of LBW even in areas where SP fails to clear a third of asymptomatic infections in women receiving SP for IPTp. These findings support the World Health Organization (WHO) recommendation to continue using SP for IPTp in these high resistance areas. The important exception is in areas with ≥37% prevalence of sextuple mutant parasites. In these areas, alternative preventive strategies are required now. The substantial levels of heterogeneity between studies, even in areas with similar levels of resistance, suggest that single observational studies of the relationship between SP doses and LBW may not be informative as a policy decision tool. Our improved understanding of the ecological relationship between molecular markers of SP resistance and the effectiveness of IPTp-SP suggests a molecular decision tool using just two or three markers in the Pfdhps gene could now be considered to guide IPTp-SP policy. van Eijk-IPTpMeta-29Oct18


The paper analyzes the four cluster characteristics of local document, that is,integration,correlation,network nature and regional identity,puts forward the new concept of local document cluster,and points out that local document cluster is an efficient mode of local document database construction,and that it is helpful to asymmetric investment,reverse gradient upgrading,sustainable development and boundless sharing of local document database construction.


Objective: We assessed the impact of preexisting dementia on in-hospital mortality, home discharge and complications of Chinese patients with intracerebral hemorrhage (ICH). Methods: Consecutive in-hospital data were extracted from the China Stroke Center Alliance database from August 2015 to July 2019. Patient characteristics, in-hospital mortality, and complications were compared between ICH patients with and without preexisting dementia. Results: Out of the eligible 72,318 patients with ICH, we identified 328 patients with pre-existing dementia. Compared with patients without dementia, those in the dementia group were older, more females and a higher proportion of individuals with lower education, and a history of diabetes, myocardial infarction, stroke, heart failure, peripheral vascular disease and cigarette smoking. Those with pre-existing dementia group were more prone to a greater stroke severity as measured by the National Institute of Health Stroke Scale (NIHSS) and Glasgow Coma Scale (GCS) at presentation. In the adjusted models, the presence of preexisting dementia was associated with an increased risk of in-hospital mortality (OR 2.31, 95% CI 1.12-4.77) and more frequent in-hospital complications of pulmonary embolism (OR 5.41, 95% CI 1.16-25.14), pneumonia (OR 1.58, 95% CI 1.08-2.33), urinary tract infection (OR 2.37; 95% CI 1.21-4.64), and gastrointestinal bleeding (OR 2.39, 95% CI 1.27-4.49). Conclusions:ICH patients with pre-existing dementia are more prone to more severe strokes and poorer outcomes. Future studies should evaluate the value of intensive risk factor control among individuals with pre-existing dementia for stroke prevention.


Reactive communication waveforms hosted in current generation tactical radios often fail to achieve good performance and resilience in highly dynamic and complex environments. Arguably, novel waveforms that can proactively adapt to anticipated channel conditions may better meet the challenges of the tactical environment. This motivates the ability to accurately predict spectral behaviour in real-time. A Long Short- Term Memory (LSTM) network is a type of recurrent neural network which has been extremely successful in dealing with time-dependent signal processing problems such as speech recognition and machine translation. In this paper, we apply it to the task of spectral prediction and present a module generator for a latency-optimised Field-Programmable Gate Array (FPGA) implementation. We show that our implementation obtains superior results to other time series prediction techniques including a naïve predictor, moving average and ARIMA for the problem of radio frequency spectral prediction. For a single LSTM layer plus a fully- connected output layer with 32 inputs and 32 outputs, we demonstrate that a prediction latency of 4.3 μ $s$ on a Xilinx XC7K410T Kintex-7 FPGA is achievable.


Essentials Red cell distribution width (RDW) is associated with future risk of venous thromboembolism (VTE). Strong interrelations between RDW and other VTE‐related diseases may explain this relationship. Cause‐specific analyses were performed to asses risk estimates of VTE by RDW. The association between RDW and VTE was not explained by myocardial infarction, stroke, or cancer.


A major open problem is to protect leveled homomorphic encryption from adaptive attacks that allow an adversary to learn the private key. The only positive results in this area are by Loftus, May, Smart and Vercauteren. They use a notion of "valid ciphertexts" and obtain an IND-CCA1 scheme under a strong knowledge assumption, but they also show their scheme is not secure under a natural adaptive attack based on a "ciphertext validity oracle". However, due to recent cryptanalysis their scheme is no longer considered secure. The main contribution of this paper is to explore a new approach to achieving this goal, which does not rely on a notion of "valid ciphertexts". The idea is to generate a "one-time" private key every time the decryption algorithm is run, so that even if an attacker can learn some bits of the one-time private key from each decryption query, this does not allow them to compute a valid private key. This is the full version of the paper. The short version, which appeared in Provsec 2016, presented a variant of the Gentry-Sahai-Waters (GSW) levelled homomorphic encryption scheme. Damien Stehlé pointed out an attack on our variant of this scheme that had not been anticipated in the Provsec paper; we explain the attack in this full version. This version of the paper also contains a new "dual" version of the GSW scheme. We give an explanation of why the known attacks no longer break the system. It remains an open problem to develop a scheme for which one can prove IND-CCA1 security.


We present a new approach in optical design whereby two- stage axisymmetric reflectors are tailored with a completely imaging strategy, and can closely approach the thermodynamic limit to radiation concentration at near-maximum collection efficiency. Practical virtues include: (1) an inherent large gap between the receiver and the second-stage mirror; (2) an upward-facing receiver; (3) the possibility of compact units (large rim angles), i.e., low ratios of total depth to total width; and (4) no chromatic aberration. We describe how one can tailor both the primary and secondary mirrors so as to insure that spherical aberration is eliminated in all orders, and circular coma is canceled up to first order in the angle subtended by the radiation source. An illustrative solution that attains about 93% of the thermodynamic limit to concentration is presented for a far-field source, as is common in solar energy and infrared detection applications. Double-tailored imaging concentrators are similar in principle to complementary Cassegrain concentrators that comprise a paraboloidal primary mirror and the inner concave surface of a hyperboloid secondary reflector, but have monotonic contours that are substantially different with far superior flux concentration.


Third grade students used wireless handhelds and a large shared display in a whole class activity to discover strategies for the control of variables in scientific experiments. The technology suite supported activity requirements including synchronous individual control, face-to-face interaction, and instantaneous display updates. In an empirical study, students demonstrated learning in both task-specific and transfer domains. Analysis of activity discourse yields a representation of "theory salience" that encapsulates student progress toward the task goal.


Since the deregulation of the Australian dollar market in December 1983, considerable effort has been devoted by the central bank to understanding movements in the value of the currency. As the Reserve Bank of Australia (RBA) has a pivotal role to play in currency markets, attention has been focussed on the modelling techniques used by the Bank's researchers in this process. This paper examines the ancestral development of the current model of the Australian Trade Weighted Index (rtwi) used at the RBA, as specified in Beechey et al. (2000). Estimates and forecasting evaluations of the various models imply that only the relationships between the rtwi, the terms of trade and interest differentials hold consistently, providing the empirical foundation for the current RBA model.


This paper reports on the methods, feedthrough modes and RF performance of wafer level packaging for RF MEMS switches. By analyzing the effects of packaging methods and feedthrough modes on the cost, weight, size, loss, RF performance and function of switches, a novel wafer level packaging structure which is performed using the wafer-level microencapsulation on the thin silicon substrate as the RF MEMS switches wafer with the vertical feedthroughs is presented. This structure has some advantages, such as low thickness, low parasitic capacity, short electric path, lightweight, no real ring and compatibility with the devices fabrication processes. Therefore, for RF applications, the packaging structure obviously reduces electric path loss and fabrication cost, and provides better RF performance of RF MEMS switches


The manufacturing industry has shifted from an antiquated Fordist model of mass production to a method of mass customization. The translation to architecture has primarily resulted in formal studies utilizing digital design and manufacturing. This over exuberant focus on the product – the technology and the things the technology can make as physical objects – rather than on the process – the social and organizational aspects of prefabrication -has resulted in furthering architecture's irrelevance in the construction industry.


352Background: Although several studies have reported on actuarial survival outcomes following resection of hilar cholangiocarcinoma, the characteristics of patients who actually reached the 5-year milestone have not been adequately described. Methods: Patients who underwent resection for hilar cholangiocarcinoma from 2000-2015 in 10 US academic institutions participating in the Extrahepatic Biliary Malignancy Consortium were analyzed. Patients alive at last encounter with less than 5 years of follow-up were excluded. The clinicopathologic characteristics, perioperative, and long-term outcomes of actual 5-yr survivors and of patients who died within 5 years were compared. Results: Of 328 patients explored, 257 (78%) underwent curative resection and had an actuarial 5-year survival of 17%. After excluding 63 survivors with < 5 years follow-up, 194 patients were further classified as 5-year survivors (n = 23, 12%) and non-5-yr survivors. None of the 5-yr survivors had preoperative systemic biliary sepsis, p...


It is researched the exisiting management system, technical standard system, and then analyzed related documents, such as management methods, specifications and regulations, examination method, of wind power prediciton in China. Finally, it is provided some suggestions on completing management system and technical standard system in the thesis, for future work in this field.


Background: The Covid-19 pandemic has had a significant impact on people's lives globally. It has affected not only physical health but also the mental well-being of the population. The pandemic itself and the subsequent lockdown brought various socio-economic hardships and stressors. These environmental and psychological factors played a central role in shaping novel psychopathological presentations. Aims: These case series aim to elucidate the role of the covid 19 pandemic in influencing the psychopathological presentation and development of psychiatric illness. Methods: Three cases uniquely impacted by the Covid 19 pandemic were identified, and structured clinical assessments were carried out. Case 1 shows how societal fears and perceptions centering around the covid 19 pandemic impacted and crept into psychopathology. Case 2 highlights the role of covid related lockdown and fear of contracting illness resulting in sensory deprivation, which lead to the emergence of psychotic symptoms in an elderly male. Case 3 depicts the onset of obsessive fear of contamination & contracting Covid infection and subsequent compulsions associated with other obsessions. Results: An understanding of the proximal and distal factors and environmental factors shaping psychopathology is vital. Early identification of these factors and prompt treatment leads to good recovery and beneficial results despite prevailing uncertainty about the pandemic Conclusion: Above case series highlights the need to have better understanding of the various factors that affect the presentation of psychiatric illness, and further qualitative studies are warranted.


The present invention discloses an environmentally friendly sheet material with a combination of a polyether, a rigid polyurethane foam and a preparation method. The polyether composition comprising the following components in parts by weight: Polyether polyol SU-450L? 2-4 parts of polyester polyol PS-23526-8 parts, 0.2-0.3 parts of a foam stabilizer, 0.3-0.5 parts of catalyst, foaming agent from 0.8 to 1.0 parts of paraffin, a flame retardant and 2 parts water, 0.18-0.22 -3 copies. The present invention employs alkane blowing agent, and has zero ODP, low GWP value. Flame retardant properties, dimensional stability and compressive strength properties of various aspects of the present invention rigid polyurethane foams are excellent. Polyurethane raw material composition of the present invention is a low smoke density during use, environmentally friendly, easy to operate, has a wide application prospect in the construction industry.


Image segmentation is a very important technique in image processing. However, it is a very difficult task and there is no single unified approach for all types of images. This paper uses graphical models to design a segmentation algorithm and tests it on some nature images. First, the algorithm over-segments an image into small regions, called superpixels. For each superpixel, we model the pixels within it by a Markov random field (MRF). Then the parameters of each MRF are estimated. The coarse segmentation of the image is obtained by clustering these superpixels based on their MRF parameters. Then an undirected graphical model, in which each superpixel is a node, is used to add interactions among the superpixels. The result shows that the algorithm can generate decent segmentation for images with clear edge cues.


Series active power filters (APF) are an important solution to deal with power quality issues in weak grids under the presence of non-linear loads. The use of voltage feedback from the critical-load-bus (cload-bus) in the series APF allows for a control strategy that has performance and processing power advantages, when compared to other strategies in literature, but can cause saturation of injection transformers. This paper presents a control strategy that uses cload-bus voltage feedback with an additional control loop of the dc current in the output of the series APF voltage source converter (VSC), to avoid injection transformer saturation. The controlled dc current is additionally used for balancing the split dc-bus capacitors voltage in the VSC. The series APF and the proposed control strategy are modeled using small signal analysis for allowing controller design. Experimental results from a 3 kVA prototype are presented, with cload-bus voltage total harmonic distortion improving from 9% to 3% in each phase, while achieving the objectives of improved cload voltage waveform, controlled transformer dc current, and balanced dc-bus capacitors voltage.


Purpose : To evaluate the anti-proliferative effect of mitomycin C (MMC) on human corneal keratocyte, and to investigate the cellular morphology of keratocyte according to the concentration and exposure time in vitro. Methods: Human corneal keratocytes using endothelium-free explant method were exposed to 0.005%, 0.01%, and 0.05% concentration of MMC for 3, 5, and 10 minutes. MTT based colorimetric assay was performed to assess the inhibition of cellular proliferation, and cellular morphology was evaluated by inverted phase-contrast light microscope and electron microscope. Results: Use of higher concentration MMC and prolongation of exposure time resulted in greater inhibitory effect on cellular proliferation. When exposed to 0.005% MMC for 3, 5 and 10 minutes, the survival rate of keratocyte was 100%, 95.7% and 74.0% respectively. At 0.01% MMC, the survival rate was 98.6%, 92.9%, and 66.9%. At 0.05% MMC, it was 74.0%, 73.4%, and 38.8%. Exposure to the highest concentration (0.05%) among the 3 preparations for 3 or 5 minutes showed significant inhibition of keratocyte proliferation (p


1. David A, Padmaja. Snake bite in pregnancy-case report and review of literature. Int J Pregnancy Child Birth 2017;2:21-3. 2. Dayal M, Prakash S, Verma PK, Pawar M. Neurotoxin envenomation mimicking brain death in a child: A case report and review of literature. Indian J Anaesth 2014;58:458-60. 3. Bawaskar HS, Bawaskar PH, Punde DP, Inamdar MK, Dongare RB, Bhoite RR. Profile of snakebite envenoming in rural Maharashtra, India. J Assoc Physicians India 2008;56:88-95. 4. Magar JS, Rustagi PS, Malde AD. Retrospective analysis of patients with severe maternal morbidity receiving anaesthesia services using 'WHO near miss approach' and the applicability of maternal severity score as a predictor of maternal outcome. Indian J Anaesth 2020;64:585-93. 5. Nawar NN, Mohamed AH, Adieb N, Emad M. The effect of maternal Naja nigricollis envenomation on the placenta. An experimental study. Biol Struct Morphog 1989;2:13-7. 6. Bajwa SJ, Mehdiratta L. Preparedness for emergencies and complications: Proactive planning and multidisciplinary approaches. Indian J Anaesth 2020;64:366-8.


The global economic crisis precipitated by the US financial collapse has spread to India first in the financial markets and has now started impacting the real economy. India was hit by the global crisis at a time when the economy was already slowing down and the crisis has brought the growth sharply down in the second half of 2008–09 and is forecast to bring it further down in 2009–10. The number of policy measures taken so far to combat the crisis will at best soften the blow but will not lead to a revival of the economy to a higher level of growth. The crisis has shattered business and consumer confidence, raised uncertainty and brought down investment and consumption demand. In this context, fiscal and monetary policies have a limited impact in stimulating the economy. Kick-starting the long-pending structural and regulatory reforms can help a strong economic recovery.


The squeezing effect of static pressure pile on soft clay foundation is analysed briefly. The radius of plastic area, the maximum compress stress caused by driving pile ,and the pore water stress can be concluded by using the cavity expansion method and the effective stress theory. On the basis of the engineering practice, several efficient and practical measures to prevent or weaken the effect on surrounding engineer are put forward.


The purpose of this study was to examine the influence of various thicknesses of opaque and dentin porcelain on the color of ceramometal restorations. A spectrophotometer was used to measure the color of the specimens and the color differences were calculated to determine the masking effect on the metal base color. The masking effect of the opaque porcelain (Vita shade A 1) fired on seven commercial ceramic alloys was different for each alloy. 86.5%-gold-content alloy specimens with 0.3-mm thickness of opaque porcelain demonstrated the maximum masking effect of the opaque single-layer. The masking effect of the opaque-dentin double-layer specimens was different for thickness and shade of porcelain. Palladium-silver alloy specimens with 0.2-mm thickness of opaque porcelain and 1.2-mm thickness of dentin porcelain demonstrated the maximum masking effect of double-layer of shade A 1. 52.5%-gold-content alloy specimens with 0.2-mm thickness of opaque porcelain and 1.2-mm thickness of dentin porcelain demonstrated the maximum masking effect of double-layer of shade C4.


This bibliography is designed to complement the article by Pablo Vila. It contains recently published academic books and articles, but excludes journalism. The discography covers significant recent music in the fields of national rock, tango, folk and 'fusion'.


A review of the geographical distribution of Neotropical species of the genus Opisthacanthus Peters (Scorpiones, Liochelidae) is presented. A new species, Opisthacanthus borboremai sp. n., is described from Santa Izabel do Rio Negro in the State of Amazonas, Brazil. This is the second record of a scorpion of the genus Opisthacanthus from Brazil. The total number of species in the Neotropical region is now raised to 7 and the known geographical distribution of the genus is enlarged.


T he recent acquisition of a major microfilm collection titled "Early English Newspapers" has added 1,412 newspapers and broadsides to the Hesburgh Libraries' holdings. This extraordinary purchase was made possible by the discernment and generosity of a group of University benefactors known as "The President's Circle." Many faculty and students are unaware of the wealth of primary sources available in the Microtext Reading Room in the Lower Level of Hesburgh Library. Various types of microformat reproduce thousands of primary source materials including books, periodicals and manuscripts from different regions of the world and from centuries past and present. A few examples are "History of Western Philosophy," "American Periodicals of the 18 Century," "Gothic Fiction: Rare Printed Works from the Sadleir-Black Collection of Gothic Fiction at the Alderman Library, University of Virginia," "Women and Victorian Values: Advice Books, Manuals, and Journals for Women," and "Manuscripts of the Irish Literary Renaissance." Besides novels, diaries and advice books, there are chapbooks, "penny dreadfuls" and other unusual formats. "The Eighteenth Century" collection alone contains hundreds of thousands of books printed in the British Isles from 1701 to 1800. "Early English Newspapers" brilliantly complements the enormous "Eighteenth Century" collection of books. Microfilming began with the collections of early newspapers gathered by Dr. Charles Burney (acquired by the British Museum--now Library--in 1818) and that of Burney's collecting rival, John Nicholls (acquired by Oxford University's Bodleian Library in 1865). Coverage was extended to the 19th century with hundreds of titles selected from various catalogs. The publisher, Primary Source Microfilm, notes: "The importance of these newspapers as a significant record of the social, intellectual, and political history of modern Europe and as a unique record of the development and diversity of the newspaper press, has become increasingly evident to scholars of the 20 th century." Taken together, these two huge microfilm collections make Notre Dame a major player in the study of 18th-century England, Ireland, Scotland and Britain's former colonies. In addition "Early English Newspapers" sheds light on daily and weekly events as well as the customs, opinions and values of 19th-century Britain. continued on page 2 From the Director by Jennifer A. Younger, Edward H. Arnold Director of University Libraries


We used the top age of storm‐relocated coral blocks (SRCBs) from Xisha Islands and Huangyan Island, South China Sea (SCS), in combination with existing paleotempestology records and instrumental climatic data, to reconstruct the spatio‐temporal changes in tropical cyclone (TC) activity over the past millennium, and to project its future trends in the Northwestern Pacific region. We found a positive correlation between the frequencies of TCs, typhoons, and super‐typhoons and the NINO3.4 on the interannual timescale during 1945–2019. TCs latitude has a significant positive correlation with sea surface temperature, with a northward migration rate of 80 ± 11 km per decade during 1951–2019. Coral δ18O can well indicate the month of paleo‐TCs occurrence. The frequency of SRCBs (and by inference, TCs) is relatively low during relatively warm periods (RWP) but high during relatively cold periods (RCP) in the SCS. The spatio‐temporal pattern inferred from paleotempestology records further supports the notion of North‐South migration in TC activity as revealed by the instrumental record in this study. TC activity mainly affected relatively low latitudes (e.g., Philippines, Vietnam, and Hainan, Guangdong, Taiwan) during the RCP (AD 1450–1900), but it migrated from low latitudes towards higher latitudes during the RWP (AD 1000–1450), affecting locations such as Zhejiang, Jiangsu, and Shandong, southwestern Japan, the Korean Peninsula, and even Northeast China. Fujian and northern Guangdong may be in a transition zone of paleo‐TC activity between the North and the South in the past millennium. As global warming continues, the mean tracks and landfall locations of TCs will continue to migrate northward in this region.


Esyeshab principle (presumed existence or continuation of a previous state or fact in disregard of its continuance having been called in question at or beyond a certain point in time) is among the four practical principles which is useful about the doubt for the imposer and determines the apparent duty. It is positively applicable in the sentences and provisions. The difference with other principles is the existence of certainty and Laheq (subsequent) doubt. Since this principle plays an important role in deduction or principles and elimination of surprise in the subjects and understanding of the many legal texts and jurisprudence is dependent on recognition of the principle and its application. The current study has been conducted due to the importance of this subject. After presenting and explaining the meaning of Esteshab in terminology and the constitutive manner and reasons for its validity , the current study will investigate the rules similar to Estehsab such as the principles of certainty, prevention, and regressive Estehsab and distinguishes and confirms their differences with this principle, explaining that due to non-completion of the conditions of Estehsab, they are not titled under this principle. The necessary material has been provided in confirming and conflicting the principles of violation, leisure, and possession. Since the Estehsab content is apparent sentence and most of the principles have not considered it as legal or judicial evidence, the mentioned principles are precedent over it and the Estehsab also takes precedence over other principles . As a preface for defining the Estehsab principle, the categorization of the principles as verbal and practical and their concise elaboration which is necessary for the detailed subject has been provided in the first sections. Since Estehsab is an aid to the priest and a useful means for legislators and judges , it is suggested a high attention be paid to training of this principle in training centers and universities-especially the faculties of law .


It is well known that data compression is such a method for the case that the function expression of an image can not be obtained. To get rid of the traditional method of data compression, a new method is proposed for the storage, processing and transmission of image data through some additive fuzzy systems in this paper. This new method is completely different from the traditional one. It uses function approximations for several different types of image blocks instead of for a whole image. The ultimate simulation results show that this new method has obvious advantages over the traditional method and has achieved the desired purpose.


This study examines whether a firm's business strategy and life cycle will influence managers' myopic behaviour in R&D investment. Using a sample of listed Taiwanese firms who have high incentives to meet earnings benchmarks from 1996 to 2010, we find that firms adopting the prospector strategy are more likely to cut R&D expenditures. In addition, we find that firms in the growth stage exhibit lower likelihood of cutting R&D expenditures to meet earnings targets. These results suggest that prospector firms are concerned more about the cost of investor undervaluation due to R&D expensing than about the future benefits that could be derived from current R&D spending. Further analysis indicates that such myopic behaviour tends to exist in firms with poor governance.


Contents: Preface Part I: Introduction 1. Transitioning from the Risk Analysis Framework to a Liability Analysis Framework Part II: Liability Assessment 2. Liability Regimes in North America 3. European Liability Regimes 4. International Economic Liability Regimes Part III: Liability Management 5. Patent Policy's Interface with Regulation and Liability 6. Coexistence Strategies and Industrial Stewardship 7. Non-adopter Liabilities within the Agri-Food Industry Part IV: Liability Communication 8. Improving Consumer Confidence 9. Regulatory Strategies for Innovative Technologies and Liability for Plant Molecular Farming Part V: Agriculture, Liability and the Future 10. Synopsis and Important Issues Bibliography Index


Methods: This single-institution prospective study was approved by the Institutional Review Board and informed consent was obtained from all patients. From November 2016 to October 2017, 84 patients, who were diagnosed as invasive carcinoma (69/84) and ductal carcinoma in situ (DCIS) (15/84) underwent both CEDM and CEMRI, were enrolled. We correlated the imaging findings and surgical management with pathologic results, and compared the diagnostic performance of both modalities in the detection of index and secondary cancers (multifocality and multicentricity), and occult cancer in contralateral breast. We also evaluated whether CEDM or CEMRI made changes in surgical management of the affected breast attributed to imaging-detected findings.


The establishment of strawberry crops in southern Brazil is conditioned on the delivery of bare-root saplings imported from Argentina and/or Chile. An alternative to reduce dependence on the acquisition of these saplings is their replacement by clod-rooted saplings that form a clod. However, information on the agronomic performance of clod-rooted saplings is scarce. The aim of this work was to investigate whether the association between types of saplings and strawberry cultivars alters fruit production and postharvest. The treatments were three cultivars (Fronteras, Monterey and Portola) and two types of saplings (bare-root and rooted in a clod), arranged in a randomized block design, with three replications. The productive potential and chemical quality of fruits were evaluated. Plants from saplings rooted in clods showed higher number and fruit production. Plants from bare -root saplings produced larger fruits. The postharvest of fruits was not altered by the treatments. It is concluded that the productive potential and postharvest of fruits of strawberry cultivars is not associated with the types of saplings studied. Regardless of the cultivar, plants from saplings rooted in clods are more productive. The three cultivars tested, of saplings with bare-roots or rooted in clods, present a balanced relationship between sugar and acidity, giving the desired flavor to the fruits in their postharvest period.


In this paper, we present a context-based access control authorization framework. Our approach is suitable to incorporate dynamically changing access control requirements. We express authorization requirements and contextual information as ontologies. The context ontology, denoted as CTXLite, serves as a core ontology for context handling. The authorization ontology, denoted as CBAC ontology, is used for modeling access control policy requirements. We use Description Logic (DL) and Logic Programming (LP) technologies for implementing Context-Based Access Control (CBAC). In our framework, access authorization decision is made based on the context of the request and the resources. We show that semantic-based techniques can support adaptive and dynamic context-based authorization. We also show that our framework is expressive enough to incorporate the needs of emerging technologies such as Internet of Things (IoT). Furthermore, we develop a proof of concept implementation to demonstrate our work. Moreover, we provide the complexity analysis of the framework and contrast the complexity against possible optimization that can be applied on the


of Leitmotiv that leads her to seek the deep causes of historical events, local or international. At times personal involvement makes itself felt, expressly or implicitly, in her tone, as when she is dealing with Mozambique or southern Africa. The book is both an original synthesis and a major contribution to African political history. It can be recommended to anyone anxious to be informed about Africa's recent past and about the historical background to the present—so crucial and so disarming when not tragic. The book is, of course, in Italian, but its originality (as English friends confirm) cries out for a translation. As an early reader (it appeared in April 1995), long before I was asked to review it, having selected the book for holiday reading I found myself hooked to the very last page.


Due to the wide availability of 5G mobile networks, joint communication and radar sensing (JCRS) receives increasing attention by research communities. Here, radar sensing can be done as a side product of communication without additional hardware costs. In contrast to dedicated radar systems, the maximum range as well as the range resolution of these systems are limited. In this paper, we have investigated the limitations of radar systems through a classification problem, recognizing 10 digit-shaped foil balloons. For this purpose, we have recorded a dataset using a 77-GHz frequency modulated continuous wave (FMCW) radar. Furthermore, we have created multiple datasets with different quality levels by reducing the range resolution and the snapshot rate of the recorded measurements. Finally, we have analyzed the behaviours of two machine learning (ML) approaches, random forests (RF) and multilayer perceptron (MLP) to understand the limitations of restricted systems.


The invention relates to metal pigments with coating, wherein the coating encases the metal pigments and chemically crosslinkable (s) and / or under the effect of heat, IR radiation, UV radiation and / or electron beam crosslinkable (s) oligomers (s) and / or polymeric comprises binder (s), wherein the coated metal pigments as a powder having a grain size d The invention further relates to a coating composition, a process for producing the coated metal pigments and their use.


The aim of this paper is to describe Kahler surfaces which admit an opposite almost Hermitian structure satisfying the first Gray condition


We consider a non-cooperative queueing environment where a finite number of customers independently choose when to arrive at a queueing system that opens at a given point in time and serves customers on a last-come first-serve preemptive-resume (LCFS-PR) basis. Each customer has a service time requirement which is identically and independently distributed according to some general probability distribution, and they want to complete service as early as possible while minimizing the time spent in the queue. In this setting, we establish the existence of an arrival time strategy that constitutes a symmetric (mixed) Nash equilibrium, and show that there is at most one symmetric equilibrium. We provide a numerical method to compute this equilibrium and demonstrate by a numerical example that the social efficiency can be lower than the efficiency induced by a similar queueing system that serves customers on a first-come first-serve (FCFS) basis.


The first thirty coefficients of a proposed series solution for a fundamental problem in nonsteady diffusion to a rotating disk have been evaluated. The results obtained raise serious questions not only with respect to potential practical applications of such a solution, but also in regard to the claimed convergence character of the series. Certain difficulties related to the numerical determination of these coefficients are discussed in detail.


Dolomite sand has several ingredients such as CaCO3 and MgO which have the potential as an antibacterial substance. The making of this antibacterial substance uses the heating/calcination method of dolomite powder with a variation of holding time from 0.5 to 2.5 hours at a temperature of 700°C. The nanoparticles produced from the calcination process were then characterized by XRD to identify the formed phase. This study aimed to determine the effect of holding time on phase formation on dolomite. The results of this study are identified as forming four phases namely calcite (CaCO3), periclase (MgO), calcium hydroxide (Ca(OH)2) and lime (CaO) with different percentages in each variation of holding time. The Ca(OH)2 and CaO phases include the impurity phase with a lower percentage than the CaCO3 and MgO phase percentages. The most dominant phase is CaCO3 and the MgO phase formed optimally at 1 hour holding time with a percentage of 47.1% CaCO3 and 35.9% MgO.


With the spreading of Internet, the security problem of Internet becomes more and more serious, for example, many websites and intranets have been attacked by hackers and the theft of important private datas is nothing surprising. Various technologied have been adopted to protect websites and subnet from being attacked by hackers, such as IPSec, VPN, Kerberos Authentication, SSL, and so on, among which Firewall is the most commonly used and most effective methods that has become the first choice for enterprises and orgnizations to guarantee net safety.


To the Editor. —The article by Myers and coworkers1 presented interesting observations on Huntington's disease progression and its relationship to several clinical variables. Specifically, the authors found significant associations between progression rate and age at onset and body weight (body mass index) at initial examination; fatter patients or late-onset patients deteriorated slower. The authors refrain from offering a biological explanation, but we think that the following might be considered. Recently, we 2 described selective neuronal loss in the hypothalamic lateral tuberal nucleus (NTL) of patients with Huntington's disease. 2 The log-transformed number of remaining NTL neurons was closely correlated with age at onset of the disease (n = 16; r = .78; P 3 The function of this nucleus, situated in the tuberal part of the lateral hypothalamus, is unknown. In rodents, the lateral hypothalamic area (LHA) is involved in a large variety of behavioral and metabolic functions, eg, in the regulation


The invention provides a magnesium-based wear-resistant damping alloy material and a preparation method thereof. A matrix of the alloy material is provided with a stable plate compound, the damping function of an alloy is improved. The method has the advantages of simple process, low production cost, and suitability for industrial production. In the alloy material, a magnesium alloy is taken as the matrix, and compound complexes are uniformly distributed on the matrix of the magnesium alloy. The alloy material comprises the following chemical compositions in percentage by weight: 5 to 9 percent of Al, 2 to 4 percent of Sr, 2 to 3 percent of Sn, 0.5 to 3 percent of Fe, 0.03 to 0.09 percent of C, 0.5 to 1.5 percent of Dy, 1.1 to 3 percent of Y, 0.5 to 2 percent of La, and the balance of Mg.


Background: Soda consumption is associated with type 2 diabetes and cardiovascular disease. Few studies have investigated the relation between sugar-sweetened and artificially sweetened soda consumption and cardiovascular risk biomarkers.

Methods: We evaluated the cross-sectional association between sugar-sweetened and artificially sweetened soda consumption and biomarkers of cardiovascular risk in 874 Mexican women from the Mexican Teachers' Cohort study. We collected information on habitual consumption (never to ≥6 times per day) of a standard 12 oz serving (1 glass, can, or bottle) of sugar-sweetened and artificially sweetened sodas through a food frequency questionnaire. Plasma concentrations of biomarkers were measured by standard methods. Geometric means were calculated where appropriate.

We used multivariable linear regression models to assess the associations of sugar-sweetened and artificially sweetened soda consumption with CRP, C-peptide, leptin, adiponectin, glucose, HDL-c, LDL-c, total cholesterol and triglycerides. Models were adjusted for age, BMI, physical activity, smoking, menopause, alcohol, family history of coronary heart disease and batches.

Results: Per 12 oz serving/d of sugar-sweetened soda consumption, CRP was 1.07 mg/dL higher (95% CI 1.03 to 1.17), triglycerides were 10.3 mg/dL higher (95% CI 2.2 to 20.4), and adiponectin was 115 ng/mL lower (95% CI -122 to -107). Per 12 oz serving/d of artificially sweetened soda consumption, C-peptide was 0.18 ng/mL lower (95% CI -0.32 to -0.02) (Table 1).

Conclusions: Intake of sugar-sweetened but not artificially sweetened sodas was significantly associated with increased plasma CRP and triglycerides, and decreased adiponectin. Artificially sweetened soda consumption was significantly associated with lower C-peptide.

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Form error is specified on the basis of an ideal geometric feature established from the actual measurements such that the maximum deviation from the ideal feature is the least possible value. The least squares method of establishing the ideal feature does not yield a minimum value. A few attempts have been made to establish the feature with a minimum value of error. In case of roundness evaluation modern instruments specify the error based on minimum deviation and ring-and plug-gauge circles. However the instrument manufacturers do not reveal the algorithms used. This paper deals with the methods of establishing the enveloping features for different geometric features namely straight line circle plane and cylinder. A non-linear optimization technique is followed to solve simple numerical examples. The values are compared with the values obtained by the least squares and minimum deviation methods. NOMENCLATURE ECF Enveloping crest feature EVF Enveloping valley feature e. Deviation of a point from assessment feature f Function to be minimized K Number of points in a section L Number of sections LSF Least squares feature 1 m Slope values (l'' for transformed values) o o 0 0 MDF Minimum deviation feature N Total number of points r. O. Polar coordinates of a point R. Radius of a circle/cylinder/ x. y. z. Cartesian coordinates of a point(x 1 1 1 1 1 1 for transformed values) x y z Estimated coordinates


This paper deals with two basic design problems that incur in a modern city transportation strategy, i.e., the Electric Car Sharing System (ECSS). Modelling the system in a modular Timed Petri Net (TPN) framework, the optimal fleet size and the number of charging positions of the ECSS are determined by a simulation analysis. The ECSS dynamics is described by taking into account fully charged, partially charged and out of power electric vehicles. Moreover, TPNs allow taking into account some particular events, like specific user flows in different time bands or the exit of the customers from the station after waiting for the availability of electric cars. A simulation study points out the effectiveness of the proposed design strategy.


Artefacts from the Early Scythian mounds whose origins are linked with Near East are the most significant part of the finds because of dating and due to possibilities to synchronize Early Scythian culture with the Near Eastern civilizations.

Difficulties in determining the time and place of production of imported items are due to their eclecticism.Significant policy changes connected with Assyrian practice of mass deportation in the VIII century B.C. led to the emergence multicultural workshops. New artistic style incorporated the achievements of the art of Asia Minor, Northern Syria, Phoenicia, Iran and Urartu.

The article is devoted to publication of the two items from Scythians monuments in the Kuban region. One of them – the part of the vessel's rim – is from the First Kelermes mound, excavated by N.I. Veselovsky. Its distinctive feature is the hatched rim for placing lid. Such vessels are unique in the North Caucasus's monuments, but wide spread in the Phrygia's tumulus and settlements. It means that Kelermes's fragment could be connected with Asia Minor.

The next one is the silver vessel on a stand decorated by the bands with sphinxes and cocks.It was bought in Maykop in 1908. Despite the slightly different style of decoration of the upper and lower parts they were used together and were made in the same workshop by two craftsman.

The study of technology and a wide range of analogies allows to determine it as a model of cauldron which could have made in the Ionian or Lydian workshops.


Frozen bull semen was thawed and diluted in three different in vitro fertilization media: TCM-199, TALP and BO. Assessment of cytoplasmicc membrane integrity and proportion of acrosome reacted sperm were accomplished by FITC-PNA lectin and PI staining in a epi-fluorescent microscope. The results showed that the number of intact, acrosome reacted and damaged membrane spermatozoa was significantly affected by both IVF medium and time of culture (p<0.001). So, the number of sperm with intact acrosome and membrane was higher when was cultured in TCM-199 (mean value 30.93+-1.18) than in TALP (28.79+-1.40) and BO (26.53+-1.31) and it was decreasing during the culture time. For the number of reacted acrosome spermatozoa was significantly higher for TALP than the others media and it was increasing during the culture period (mean value TALP 9.33+-0.81, TCM-199 6.76+-0.64, BO 7.33+-0.54),. In relation to died sperm, BO was significantly higher than the others media and the relation between the number of acrosome reacted and total intact membrane spermatozoa was lower for TCM-199 than the other; finally, the process of acrosome reaction was slower than BO and TALP.


OBJECTIVES
To assess the impact of bone growth on the flexion contracture angle at the knee, to measure the bone growth pattern in rats, and to assess the impact of immobility on bone growth.

DESIGN
Experimental, controlled study.

SETTING
Bone and joint laboratory.

ANIMALS
Sixty Sprague-Dawley rats.

INTERVENTIONS
Knee joints of 40 rats were immobilized unilaterally in flexion. Sham-operated animals (n = 20) were controls.

MAIN OUTCOME MEASURES
The contracture angle and the femur and tibia lengths on radiographs.

RESULTS
The angle of flexion increased over time and was largely explained by bone growth (r =.725, p <.01). Femur and tibia grew in rats until they were 11 months old. Immobility enhanced growth in bone length, especially of the femur, after 16 and 32 weeks of immobility (p <.05).

CONCLUSIONS
Knee flexion contracture angle increased as a consequence of normal bone growth, a situation that is also encountered in skeletally immature children. The continued growth in length of bones in children may influence the progression of contractures and add to the therapeutic challenge. Ongoing bone growth should be considered when interpreting reports that use animal models for bone and joint diseases.


Determination of 23 populations of field dodder was conducted using light and scanning electron microscopy and subsequent molecular (PCR) methods in order to fully examine the biology and ecology of Cuscuta campestris and options for its control. The effects of different temperatures and rhizobacteria (PGPR) on germination of C. campestris seeds, as well as effects of different light treatments (red, far-red and blue light) on germination, growth, and height of attachment points of field dodder shoots on alfalfa stems were also investigated. We examined the effects of C. campestris on morphological (visualisation and fresh weight), anatomical (anatomy of leaf and stem of alfalfa; leaf and petiole of sugar beet) and physiological parameters (relative chlorophyll content, total carotenoids, nitrogen, phosphorus, potassium, organic and mineral matter and chlorophyll fluorescence) in alfalfa and sugar beet plants exposed and unexposed to herbicides (imazethapyr, glyphosate, propyzamide). The efficacy of imazethapyr, glyphosate, propyzamide and diquat in controlling field dodder in alfalfa crop was examined in field trials. After examining 23 populations of field dodder, two species of the genus Cuscuta were identified: Cuscuta campestris Yunk. and Cuscuta epithymum (L.) Nath. An optimal temperature for germination of C. campestris seeds was found to be 30 ̊C and treatment with red light (for 1h at daytime) produced the highest percentage of germinated seeds, while the highest percentage of seedlings attached to alfalfa stems at 4.65 cm height was found after treatment with far-red light (for 45 min at daytime). Also, the highest percentage of germinated field dodder seeds was recorded after treatment with the rhizobacterium Azotobacter chroococcum isolated from wheat rhizosphere. An analysis of our data showed that the highest values of most parameters (visualization and fresh weight; relative content of chlorophyll and total carotenoids, effective yield and intensity of fluorescence, variable fluorescence, variable/maximal fluorescence ratio; thickness of stem epidermis, thickness of cortex, thickness of central cylinder and stem diameter of alfalfa; thickness of upper and lower leaf epidermis, thickness of palisade and spongy mesophylls, thickness of mesophyll in alfalfa and sugar beet leaves; diameter of tracheids, petiole hydraulic conductance, xylem area, diameter of phloem cells and petiole phloem area of sugar beet) were found in noninfested alfalfa and sugar beet plants, then in infested plants treated with herbicides, and the lowest in plants infested by C. campestris but untreated with herbicides. C. campestris was found to affect and reduce nearly all parameters of stem, leaf and petiole anatomy of the host plants, in contrast to some physiological parameters. The infested alfalfa and sugar beet plants were found to have higher contents of nitrogen, phosphorus, potassium and organic matter, compared to non-infested plants. The highest efficacy in controlling field dodder in alfalfa field was demonstrated by diquat (product Reglon forte 3 l/ha), then by glyphosate (product Glifol 0.8 and 1 l/ha), while the other two tested herbicides (propyzamide – product Kerb WP-50 and imazethapyr – product Pivot 100 M) showed lower efficacy.


Background: The development of safe and effective chimeric antigen receptor T-cell (CAR-T) therapy for acute myeloid leukemia (AML) remains an elusive goal. Whereas CD19-directed CAR-T therapies have shown great promise for the treatment of B-cell malignancies, the identification of AML-associated surface antigens that can be safely and effectively targeted by CAR T-cells has remained a challenge. Because most AML-associated surface antigens are also expressed on normal myeloid progenitors, the potential for unacceptable hematopoietic toxicity has been a major limitation. The identification of cell surface antigens that are absent on all normal myeloid progenitors and yet expressed on all subtypes of AML is not likely. On the other hand, it seems plausible that some antigens not detected on early myeloid lineage cells may be preferentially overexpressed in certain AML subtypes. We have identified B7-H3 as one such candidate. B7-H3 (B7-homolog 3, or CD276) is a coreceptor belonging to the B7 family of immune checkpoint molecules. B7-H3 protein expression in normal tissues is largely restricted to certain antigen-presenting cells. In multiple human cancers, however, B7-H3 protein is significantly overexpressed. This includes a substantial subset of AML, and B7-H3 expression appears to be higher in AML with a monocytic immunophenotype. Furthermore, B7-H3 on tumor cells, and on myeloid-derived suppressor cells in the tumor microenvironment, is likely to play an immunosuppressive role, and may drive immune escape in multiple cancer types. This suggests that targeting B7-H3 could also enhance anti-tumor adaptive immune responses. We therefore hypothesized that B7-H3-specific CAR-Ts (B7-H3.CARs) could be effective in eliminating B7-H3-expressing AML cells and would not cause unacceptable hematopoietic toxicity.
 Methods and Results: We obtained bone marrow aspirates from patients with monocytic/myelomonocytic AML (n=10) and demonstrated surface expression of B7-H3 on a median of 62.5% (range 27.8 to 98.5) of primary AML blasts. We also showed that B7-H3 is highly expressed on monocytic/myelomonocytic AML cell lines (THP1, U937, OCI-AML2, OCI-AML3), and that B7-H3 expression compares favorably to that of other previously identified candidate antigens for AML-directed CAR-T therapy. Next, we generated B7-H3.CARs via retroviral transduction of CD3/CD28-activated T-cells, followed by expansion in vitro with interleukin- (IL) 7 and IL-15. When B7-H3.CARs (n=3-5 donors) were cocultured with B7-H3-positive AML cell lines (listed above) and with primary AML blasts (n=10 patients), B7-H3.CARs proliferated, released high amounts of IL-2 and interferon-γ, and demonstrated efficient B7-H3-specific cytotoxicity. Autologous B7-H3.CARs also demonstrated significant cytotoxicity against primary AML blasts (n=4). Additionally, B7-H3.CARs controlled tumor cell proliferation and prolonged survival in xenograft mouse models of disseminated AML using OCI-AML2 (p=0.0025, n=5 mice per group) and THP1 (p<0.0001, n=10 mice per group).
 Next, we showed that B7-H3 is not significantly expressed on hematopoietic stem cells or myeloid progenitor cell populations in normal human bone marrow samples (n=2). We also evaluated the effects of B7-H3.CARs (n=4 donors) on normal hematopoietic stem cells via in vitro colony formation assays using umbilical cord-blood (n=4 donors) derived CD34+ cells, and showed that B7-H3.CARs did not significantly inhibit the formation of myeloid progenitor colonies. We then showed in a humanized mouse model (using fetal liver-derived hematopoietic stem cells) that B7-H3.CARs did not lead to significant reductions in the populations of circulating CD45/CD14-positive or CD45/CD33-positive cells.
 Conclusions: B7-H3 is expressed on a significant proportion of AML blasts from patients with monocytic AML. Adoptive transfer of B7-H3.CARs could be an effective treatment option for patients with B7-H3-positive AML, since i) we have previously demonstrated limited expression of B7-H3 in normal tissues, and ii) the present results show that B7-H3.CARs are unlikely to cause significant hematopoietic toxicity. Given variable expression of B7-H3 in AML, however, it may be necessary to develop a dual-targeting approach, combining B7-H3 with a second target AML-associated surface antigen.

 Du: N/A: Patents & Royalties: Patent filed for B7-H3 chimeric antigen receptor. Ferrone:N/A: Patents & Royalties: Patent filed for B7-H3 chimeric antigen receptor. Dotti:University of North Carolina: Patents & Royalties: Patent filed for B7-H3 chimeric antigen receptor.


ENTISTRY HAS assumed a leadership position among the health sciences by its early commitment to preventive care. Fluoride applications alone have substantially reduced the economic and human suffering caused by oral disease.' However, the Commitment by the profession has largely overlooked the edentulous patient, concentrating on the young in the effort to protect and preserve the natural dentition. Currently, there are more than 44 million people wearing full or partial dentures who could benefit from the profess ion ' s commitment t o prevent ive therapy . 2 It is erroneously believed that attempts to educate and motivate the complete denture patient are wasted efforts, and that these patients are edentulous because they did not properly maintain their teeth, and any preventive program will be poorly received. It is assumed that edentulous patients have a fatalistic attitude toward their oral condition and that they will not perceive the benefits in routine oral hygiene procedures. As part of a larger study that attempted to implement and evaluate the effectiveness of oral hygiene procedures for the edentulous patient, an instrument was administered that measures the perceptions and attitudes of these people toward their oral condition.


Background The integration of multi-omics information (e.g., epigenetics and transcriptomics) can be useful for interpreting findings from genome-wide association studies (GWAS). It has additionally been suggested that multi-omics may aid in novel variant discovery, thus circumventing the need to increase GWAS sample sizes. We tested whether incorporating multi-omics information in earlier and smaller sized GWAS boosts true-positive discovery of genes that were later revealed by larger GWAS of the same/similar traits. Methods We applied ten different analytic approaches to integrating multi-omics data from twelve sources (e.g., Genotype-Tissue Expression project) to test whether earlier and smaller GWAS of 4 brain-related traits (i.e., alcohol use disorder/problematic alcohol use [AUD/PAU], major depression [MDD], schizophrenia [SCZ], and intracranial volume [ICV]) could detect genes that were revealed by a later and larger GWAS. Results Multi-omics data did not reliably identify novel genes in earlier less powered GWAS (PPV<0.2; 80% false-positive associations). Machine learning predictions marginally increased the number of identified novel genes, correctly identifying 1-8 additional genes, but only for well-powered early GWAS of highly heritable traits (i.e., ICV and SCZ). Multi-omics, particularly positional mapping (i.e., fastBAT, MAGMA, and H-MAGMA), was useful for prioritizing genes within genome-wide significant loci (PPVs = 0.5 – 1.0). Conclusions Although the integration of multi-omics information, particularly when multiple methods agree, helps prioritize GWAS findings and translate them into information about disease biology, it does not substantively increase novel gene discovery in brain-related GWAS. To increase power for discovery of novel genes and loci, increasing sample size is a requirement.


The pharmacokinetics and pharmacodynamics of a novel xanthine oxidase (XO) inhibitor, Y-700, were evaluated in rats and healthy male volunteers. In a rat model of hyperuricemia, oral Y-700 (0.3–10 mg/kg) showed a more potent and a longer-lasting hypouricemic action than allopurinol. A single oral dosing of Y-700 (5, 20 or 80 mg) to volunteers caused a dose-dependent reduction of serum uric acid levels indicating close relationship to plasma concentrations of the compound. In addition, Y-700 was hardly excreted in urine but mainly excreted in feces in rats and volunteers. These results suggested that Y-700 is a new effective inhibitor of XO in rats and humans with high oral bioavailability being predominantly eliminated via the liver unlikely to allopurinol.


. This paper investigated thin fi lms deposition processes of silica-like based on the injection of liquid droplets in Atmospheric Pressure Plasma Jet – APPJ operated in open air. An aerosol of hexamethyldisilane is produced by a syringe-pump and injected in a nitrogen post-discharge for different liquid precursor and carrier gas fl ow rates. For high carrier gas fl ow, this process enables to form silica-like without addition of oxygen in the plasma phase. Furthermore, this process offers a thin fi lm dynamic deposition rate from 500 to 1400 nm.m.min (cid:1) 1 depending on the carrier gas fl ow and the fi lm structure departs from silica-like to organosilicon layers for the lowest fl ow rates. These evolutions are attributed to plasma – droplets interactions related to the transport of droplets, the evaporation of liquid and plasma polymerization.