Aim. To study the hemostatic system parameters and magnesium levels in patients with beta-thalassemia.
Methods. The object of the study was the blood serum of 96 women with beta-thalassemia: 46 patients with intermediate beta-thalassemia and 50 patients with beta-thalassemia minor, without clinical manifestations of hypercoagulation. The blood serum of 30 healthy donors was used as the control group. It was studied hemostasis system parameters: platelet count activated partial thromboplastin time (aPTT), prothrombin time, plasma fibrinogen level, D-dimer level, euglobulin clot lysis time, antithrombin III activity. The serum magnesium level and risk of deficiency were determined using the MDQ questionnaire.
Results. In patients with intermediate beta-thalassemia, an increase in the level of thrombinemia marker D-dimer (500 ng/ml) was revealed. Patients with intermediate beta-thalassemia were divided into two groups according to the revealed level of D-dimer: 14 (30.46.8%) patients with latent hypercoagulation in group 1 and 32 (69.66.8%) patients without latent hypercoagulation in group 2. It was found that in the group with a high levels D-dimer, fibrinogen level was increased (p 0.05), fibrinolysis time was prolonged (p 0.05), activated partial thromboplastin time was shortened (p 0.05), and antithrombin III activity was slightly reduced (p 0.05). The serum magnesium level in patients of the first group was lower (t=7.3; p 0.001), and the risk of deficiency in the questionnaire was higher than in patients of the second group (r=0.785, p 0.05). Hemostasis and magnesium levels in patients with beta-thalassemia minor did not differ from the control group (p 0.05).
Conclusion. One-third of patients with intermediate beta-thalassemia have a pre-thrombotic state for hemostasis latent hypercoagulation and magnesium deficiency which can be predictors of clinical signs of thrombosis.


The main goal of this thesis is to describe psychological principles in general, which brings good function of teamwork. For successful leadership of team is very important not only good knowledge of those principles, but one has to know how them apply into specific environment of sound postproduction.
The first third of thesis speaks generally about socio-psychological relationships inside team as the unit and describes main principles of its function.
Second two third of thesis analyse sound supervisor as a team leader and specify his work activity, for example how he should correctly create team and coordinate it. In next chapters is described specific environment of sound postproduction and is created model of ideal team in the sense of good function. Then, are described differences between temporal and long-lasting teams. By comparing their characteristics with solitaire model of work, one can tell which are the most suitable solutions for environment of sound postproduction.
Final comparing of ideal and theoretical model with everyday reality closes whole thesis.


The muon anomalous g value, a(mu) = (g - 2)/2, is calculated up to one-loop level in noncommutative QED. We argue that relativistic muon in E821 experiment nearly always stays at the lowest Landau level. So that spatial coordinates of muon do not commute each other. Using parameters of E821 experiment, B = 14.5 KG and muon energy 3.09 GeV/c, we obtain the noncommutativity correction to a(mu) is about 1.57 x 10(9), which significantly makes standard model prediction close to experiment.


The invention provides an injection method for controlling volume of tidal (VT) of a metal oxide semiconductor (MOS) device. According to the injection method, doping is performed in an active region once or more times with different types of doping energy; a first doped layer and a second doped layer are formed at different depth positions respectively in a substrate below a grid; and therefore, the drain induced barrier lowering (DIBL) effect can be reduced, and the performance of the MOS device can be improved.


DETAILS ARE GIVEN OF THE SUBURBAN RAILWAY PROJECT FOR THE TOWN OF MEXICO IN WHICH CONGESTION AND POLLUTION EXIST ON A LARGE SCALE. THIS PUBLIC TRANSPORT SYSTEM WILL LINK THE PERIPHERAL ZONES OF THE FEDERAL DISTRICT AND SHOULD SOLVE THE TRAFFIC PROBLEMS OF THE CAPITAL.


Summary.  Approximately 25% of severe hemophilia A patients develop antibodies (Ab) that neutralize the procoagulant function of factor (F)VIII (inhibitors). Autoimmune FVIII inhibitors may develop in individuals without congenital FVIII deficiency and cause acquired hemophilia. Low titers of anti‐FVIII Ab may be present in hemophilia A patients without inhibitors and in healthy blood donors. FVIII‐specific CD4+ T‐cells drive the synthesis of anti‐FVIII Ab. We examined the epitope repertoire of CD4+ T‐cells from 15 healthy subjects, 10 hemophilia A patients without inhibitors, 11 hemophilia A patients with inhibitors, and six acquired hemophilia patients. Blood CD4+ T‐cells were challenged in proliferation assays with a panel 16 overlapping synthetic peptides, spanning the sequence of the FVIII C2 domain. The sequence region 2291–2330 contained the most frequently and strongly recognized peptides in each of the four subject groups. Crystallographic B factor data and the location of these peptides within the three‐dimensional structure of the C2 domain confirm that this region has a high degree of solvent exposure and flexibility within the peptide backbone, which are structural features typical of immunodominant universal CD4+ epitopes. Furthermore, this sequence region overlaps inhibitor‐binding sites, suggesting that CD4+ T‐cells recognizing peptide sequences within this region might be involved in inhibitor synthesis. The sequence regions 2191–2210 (recognized strongly by each study group except hemophilia A patients with inhibitors) and 2241–2290 (recognized primarily by acquired hemophilia patients and healthy subjects) share the same structural features, and also overlap inhibitor‐binding sites. Although similar, there appear to be important differences in the CD4+ epitope repertoires of congenital and acquired hemophilia patients.


Abstract Using proposed Environmental Protection Agency histologic guidelines for selection of maximum tolerated doses in rodent carcinogenesis bioassays, our pathologists encountered a general problem with assessing the onset of hyperkeratosis and crusting from hematoxylin and eosin (H&E) preparations. Although the H&E stain is commonly used for routine analysis of skin samples for histopathology evaluation, it is usually limited in its capability to distinguish key lesions that are important in dermal bioassays. In seeking to identify a stain to act as an adjunct to the standard H&E method, we screened a series of stains. The best differentiation of early hyperkeratosis and crusting was seen with a modified fourcolor histochemical procedure. This procedure stains keratin a bright yellow and crusting exudates a bright pink to provide an early indicator of skin lesions. This stain is a possible adjunct to the standard H&E in diagnosis of rodent dermal bioassays. (The J Histotechnol 17:33, 1994)


The first steps on the way to the new century were marked by the almost instantaneous introduction of the latest information and communication technologies in all spheres of life and the desire to remove with their help the deep problems of the organization of our lives. We waited for it with incomprehensible thirst, and some invisible force pushed us to break the chains that connected the present with all the testaments of the past, which, however, have the meaning of real life.

The world of digital technologies, in which we are immersed deeper, really changes our attitude to them and we should know that this is not only a new logical stage in the technological sphere of human development, but also the transformation of all legal, socio-political and, above all, scientific and educational reality. Unfortunately, there are still not many generally accepted and harmonized philosophical definitions and legal definitions, without which it is impossible to build a policy, however, digital technologies are already rapidly capturing bridgeheads for development, causing new risks and threats to which we must prepare an algorithm.

Key words: information, communication, information and communication technologies, digitalization, digital society, education, national security.


Aims: To determine risk factors for development of microalbuminuria (MA) in relation to detection of limited joint mobility (LJM+) of the interphalangeal joints in a longitudinal cohort of type 1 diabetic (T1DM) subjects. Methods: A total of 479 T1DM subjects diagnosed <16 years were followed from diagnosis of diabetes with annual assessments consisting of assessment of LJM, measurement of HbA1c and insulin-like growth factor 1 (IGF-1), and three urine samples for albumin:creatinine ratio (ACR). Results: After a median follow up of 10.9 years, 162 subjects (35.1%) developed LJM at median age 13.0 years and duration 5.2 years. More subjects developed LJM after compared to before puberty (67.6 v 32.4%). In LJM+ compared to LJM− subjects, HbA1c (mean 10.1 (SD 1.6) v 9.6 (1.4) %)) and ACR levels (median 1.1 (range 0.2–242.9) v 0.9 (0.4–70.7) mg/mmol) were higher, and in a Cox model probability of developing LJM was related to puberty and higher HbA1c levels. ACR levels were higher after detection of LJM compared to before (median 1.2 (range 0.4–102.6) v 0.8 (0.2–181.9) mg/mmol). Probability of developing MA was related to puberty, HbA1c, female sex, and presence of LJM (a 1.9-fold increased risk). Both LJM and MA were associated with lower height SDS (LJM: mean 0.0 (SD 1.0) v 0.2 (1.1); MA: 0.0 (1.0) v 0.2 (SD 1.0)) and lower IGF-1 levels. Conclusion: The development of LJM was associated with an increased risk of microalbuminuria, independent of glycaemic control. Risk for both microalbuminuria and LJM was associated with puberty, reduced growth, and reduced IGF-1 levels, and may indicate underlying shared pathogenic mechanisms.


In this paper, we propose a neural vocoder-based text-to-speech (TTS) system that effectively utilizes a source-filter modeling framework. Although neural vocoder algorithms such as SampleRNN and WaveNet are well-known to generate high-quality speech, its generation speed is too slow to be used for real-world applications. By decomposing a speech signal into spectral and excitation components based on a source-filter framework, we train those two components separately, i.e. training the spectrum or acoustic parameters with a long short-term memory model and the excitation component with a SampleRNN-based generative model. Unlike the conventional generative model that needs to represent the complicated probabilistic distribution of speech waveform, the proposed approach needs to generate only the glottal movement of human production mechanism. Therefore, it is possible to obtain high-quality speech signals using a small-size of the pitch interval-oriented SampleRNN network. The objective and subjective test results confirm the superiority of the proposed system over a glottal modeling-based parametric and original SampleRNN-based speech synthesis systems.


This chapter reviews the production of fables in Hans Blumenberg's "Unknown Aesopica: From Newly Found Fables" (1985). Aesop was — if he ever really existed — a slave. Based on his origin, he is referred to as a Phrygian, in some sources as Lydian, in better ones as Thracian. By betraying the secret of Aesop, Socrates subtly implied how the fable — which he was the first to put into verse while in prison awaiting his death — arrived at the inexhaustibility of its wisdoms: the forefather of all philosophy was also that of all fables. Thus, the disconcerting problem that Aesop placed himself on rare occasions in his stories (which were therefore suspected to be apocryphal) is finally solved. The new findings, three of which are presented here, prove that intermediate forms between animal fable and anecdote belong to the original stock: Aesop with his talking animals.


Ječná 1321/29a, 621 00 Brno, Czech Republic Meliata unit, Western Carpathians, Slovakia: implications of phyllosilicate characteristics. International Journal of Earth Sciences, 92(1): 68-85. FARYAD S.W. and HENJES-KUNST F., 1997. K-Ar and ArAr age constraints of the Meliata blueschist facies rocks, the Western Carpathians (Slovakia). Tectonophysics, 280: 141-156. FARYAD S.W., SCHULMANN K. and LEXA O., 2004. Structure and metamorphism of teh Meliata Unit: Pre-conference field trip. Geolines, 17: 113-120. JANÁK M., PLAŠIENKA D., FREY M., COSCA M., SCHMIDT S.Th., LUPTÁK B. and MÉRES S., 2001. Cretaceous evolution of a metamorphic core complex, the Veporic unit, Western Carpathians (Slovakia): P-T conditions and in situ 40Ar/39Ar UV laser probe dating of metapelites. Journal of Metamorphic Geology, 19 (2): 197-216. LEXA O., SCHULMANN K. and JEZEK J., 2003. Cretaceous collision and indentation in the West Carpathians: View based on structural analysis and numerical modeling. Tectonics, 22(6), art. no.-1066.


BACKGROUND
Antibody-dependent cell-mediated cytotoxicity (ADCC) is an important pathway responsible for antibody-mediated rejection (AMR). Imlifidase (IdeS) cleaves human IgG into F(ab')2 and Fc fragments, potentially inhibiting ADCC. Here we examined the effect of imlifidase on allo-antibody-mediated NK cell activation (Allo-CFC) and ADCC in vitro.

METHODS
For Allo-CFC, normal whole blood was incubated with third-party peripheral blood mononuclear cells (PBMCs) pretreated with anti-HLA antibody positive (HS) or negative (NC) sera to measure IFNγ+ NK cell%. For ADCC, normal PBMCs were incubated with Farage B cells (FB) with HS or NC sera to measure 7-AAD+ lysed FB cell%. To assess the effect of imlifidase on these assays, serum-treated PBMCs (Allo-CFC-1) and serum used for PBMC pretreatment (Allo-CFC-2) in Allo-CFC, and serum used for ADCC were preincubated with imlifidase. Sera from imlifidase-treated patients were also tested for Allo-CFC (Allo-CFC-3).

RESULTS
IFNγ+ NK cell% were significantly elevated in HS vs. NC sera in Allo-CFC-1 (10 ± 3% vs. 2 ± 1%, p=0.001), Allo-CFC-2 (20 ± 10% vs. 4 ± 2%, p=0.01) and 7AAD+ FB cell% (11 ± 3% vs. 4 ± 2%, p=0.02) in ADCC. These were significantly reduced by imlifidase treatment. Patient sera with significantly reduced anti-HLA antibody levels at 1 day postimlifidase lost the capacity to activate NK cells in Allo-CFC-3, but those at 1-3 months postimlifidase regained the capacity.

CONCLUSIONS
Imlifidase inhibited NK cell activation and ADCC in vitro and in treated patients. These results and reported inhibition of complement activating anti-HLA antibodies by imlifidase suggest its possible role in treatment of AMR.


Anuran frogs of the genus Fejervarya Bolkay, 1915 are, perhaps, the most widely distributed Asian amphibians in the world. Presently, the genus Fejervarya includes around 45 species worldwide, of which 29 species are found to occur in India, mostly in the Western Ghats (Frost, 2017). Of these 29 species, only 5 species are known to occur in North-East India. They are F. nepalensis (Dubois, 1975), F. pierrei (Dubois, 1975), F. syhadrensis (Annandale, 1919), F. teraiensis (Dubois, 1984) and F. sengupti Purkayastha & Matsui, 2012 [Ao et. al., 2003; Borthakur et. al., 2007; Ningombam and Bordoloi, 2007; Ahmed et al., 2009; Mathew and Sen, 2010; Purkayastha and Matsui, 2012]. So far, only 4 species of Fejervarya viz. F. syhadrensis (Annandale, 1919), F. teraiensis (Dubois, 1984), F. pierrei (Dubois, 1975) and F. sengupti Purkayastha & Matsui, 2012, have been reported to occur in Meghalaya. Recently, during joint field surveys to the Sacred Groves of East Khasi Hills District, Meghalaya, undertaken by one of the authors (IJK) along with staff of the Forest Resources Division, Forest Department, Government of Meghalaya; several specimens of Fejervarya, among other anurans species, were collected. Taxonomic studies on this collection revealed some of these frogs to be Fejervarya nepalensis (Dubois, 1975). The species has never been recorded from Meghalaya, though it has been hypothesised to occur in areas in between its reported range of distribution. So this present paper, besides proving this hypothesis also forms the first record of the species from the State.


Directed toward a new construction craft,drawing anchorage cable to rectify the offset of the tower of suspension bridge,based on the principle of invariable zero-stress cable length,a method of calculation of pre-allowance of the drawing anchorage cable is determined.Based on the structural control theory of suspension bridge by finite element program,the control technique for drawing anchorage cable is studied.The application result expresses that: the difference value of every cable's stress should be controlled under 150 MPa,and horizon deviation of main towers should be controlled under 5 cm;after having tensioned several times,the cable's tension become well distributed;the ratio of the maximum difference value of every cable's tension between theory and actual measurement to theoretic tension is less than 5%;during the construction of the bridge,the obligated deviation of towers is 53 cm,the method of calculating the obligated deviation is simple and accurate.1 tab,4 figs,9 refs.


The present study attempted to assess the performance of Fisherwomen's self help groups (SHGs) in Tamil Nadu . Primary data required for the study were collected from 725 fisherwomen SHG members representing 41 SHGs from five coastal villages - Tharuvaikulam, Pazhayakayal and Therespuram in Thoothukudi district and Kootapuli and Uvari in Tirunelveli district - during May –October 2004. The study found the fisherwomen SHGs performing well in availing and repaying microcredit which had contributed to their socio – economic empowerment and to better livelihood conditions. [Report submitted to NABARD, 2005.]


O'Hurley G, Perry A S, O'Grady A, Loftus B, Smyth P, O'Leary J J, Sheils O, Fitzpatrick J M, Hewitt S M, Lawler M & Kay E W
(2011) Histopathology 59, 1240–1248
The role of secreted frizzled‐related protein 2 expression in prostate cancer


eye such as cataract, glaucoma, and microphthalmia. Most infants with the expanded syndrome, however, also had hepatosplenomegaly and a bulging anterior fontanelle and were of low birth weight. Another feature of the syndrome was the presence of characteristic lesions in the metaphysis of the long bones.8 These lesions appeared on x-ray films as abnormal areas of translucency. Similar bone changes were observed in half the infants born in the Philadelphia General Hospital during the epidemic period and are described by Dr. J. M. Lindquist and his colleagues at page 1401 of this week's B.M.7. Dr. Lindquist and his colleagues found osteoclasts in the tibial lesions of one child and postulate that the lesions are due to viral osteitis. A. J. Rudolph and his co-workers, on the other hand, think that the changes are due to a defect in the formation of bone which is secondary to metabolic or nutritional disturbances.8 Similar radiological changes in the long bones are occasionally seen in newborn children suffering from other diseases, but they have not previously been reported in congenital rubella. Fortunately, the bone lesions -like the thrombocytopenia-generally resolve in the early months of life. The infants studied in Philadelphia showed a lower incidence of thrombocytopenia than those reported in other studies. Furthermore, none of them showed myocardial necrosis, jaundice, hepatitis, interstitial pneumonia, or anaemia-though these disorders have been noted in a few infants with the expanded rubella syndrome by other workers.4 9 Despite the severity of the congenital rubella which followed this outbreak the total incidence of congenital defect after maternal rubella in the first trimester was 10%,1o which is no higher than that observed in previous surveys.'1 12 This suggests that although the particular strain of virus associated with the outbreak caused unusually severe disease it did not infect the foetus more often. Epidemiological surveys have established that foetal infection may follow inapparent subclinical maternal rubella.'3 14 It may therefore be difficult to diagnose the congenital rubella syndrome if there is no history of maternal rubella or if-as sometimes happens-there is also no known exposure to infection during pregnancy. If a newborn infant is suspected to be suffering from congenital rubella, confirmation should be sought by taking throat swabs or other specimens for attempted isolation of the virus. Infants with the expanded rubella syndrome-like those with classical congenital rubella -suffer from a chronic infection with rubella virus, and the virus can readily be isolated from throat, urine, or rectum during the first months of life.2'4 The affected infants are infectious, and cases of rubella have been observed among their attendants and family contacts.' 15 16 Studies have also been reported that show that immunity to reinfection with rubella virus is associated with the presence of neutralizing antibody.'6 17 Volunteers who had been inoculated with the virus and persons exposed to infection from cases of the disease almost invariably failed to develop infection if they possessed detectable antibody. In contrast, those who lacked antibody suffered a high attack rate of clinical or subclinical rubella. Since the presence of neutralizing antibody is associated with almost certain immunity to rubella there is clearly hope of successful artificial immunization. The effects of a live virus vaccine have already been investigated in a small group of children.'8 The vaccine caused a mild illness with the production of antibody when it was inoculated subcutaneously, but there was no response if it was administered intranasally. Virus was present in the throat of the children inoculated subcutaneously and persisted up to three weeks after inoculation. Unfortunately, these children proved to be infectious and there were some cases of rubella among their contacts. This type of vaccine is probably, therefore, unsuitable for general use, but virological developments in the study of rubella are progressing rapidly and a better vaccine may yet be possible.


Fault propagation analysis is an important task that can be used to analyze and predict abnormal situations in chemical and petrochemical plants. It is difficult to identify all possible fault propagation scenarios due to plant complexity, operating condition changes, and computation limitations. In this paper, development of root cause and consequence analysis is proposed. Computational intelligence algorithm is proposed to synthesize fault propagation scenarios based on plant topology nodes. Automated solution is developed and used to synthesize and analyze fault propagation scenarios, which are used for real-time fault diagnosis and safety assessment using case study chemical plant


The antihistamines astemizole and cetirizine were compared for the treatment of grass pollen hayfever in 158 patients who received either astemizole (10 mg od) or cetirizine (10 mg od) for a four week period in a randomised double‐blind, double‐dummy, parallel group, comparative assessment.


Current market conditions, dire as they are, represent not a black swan but a predictable surprise. Unfortunately, behavioral impediments in human nature made most investors unwilling or unable to see this predictable surprise. But despite the uncertain state of today's markets, the investment environment holds many opportunities for value investors who focus on the long term.


We analyzed emission intensity, quantum efficiency, and emitted light polarization of c-plane AlGaN and AlInGaN layers (λ = 320–350 nm) by temperature dependent photoluminescence. Low indium content in AlInGaN structures causes a significant intensity increase by change of the polarization of the emitted light. Polarization changes from E ⊥ c to E ‖ c with increasing aluminum content. It switches back to E ⊥ c with the incorporation of indium. The polarization degree decreases with temperature. This temperature dependence can corrupt internal quantum efficiency determination by temperature dependent photoluminescence.


Background: Research evidence shows that non-alcoholic fatty liver disease (NAFLD) is closely related to inflammation. Objectives: This study aimed to evaluate the response of inflammatory biomarkers to 10 weeks of aerobic resistance exercise in inactive postmenopausal women with NAFLD. Methods: In this purposeful quasi-experimental study, conducted in Mahshahr, Iran, in 2019, 24 inactive women aged 50 - 68 years who were diagnosed with fatty liver disease by ultrasound were randomly divided into training or control groups. The training group performed aerobic resistance training for 10 weeks using treadmills and bodybuilding machines. At the beginning and end of the study, serum interleukin 18 (IL18), interleukin 10 (IL10), and other blood parameters were measured, and the subjects underwent liver ultrasound and anthropometric evaluations. Results: The results of intergroup ANCOVA, intragroup paired t-test, and Wilcoxon showed that in response to 10 weeks of training, IL18 levels, anthropometric parameters, insulin resistance (HOMA-IR), liver enzymes, fasting glucose, triglyceride (TG), and liver fat were significantly decreased and plasma IL10 was significantly increased when compared to baseline results (P < 0.05). Also, the results of the Spearman correlation test showed a significant positive relationship between IL18 and waist circumference (WC), alanine aminotransferase (ALT), and HOMA-IR and a significant negative relationship between IL10 and weight, WC, TG, HOMA-IR, and liver fat (P < 0.05). Conclusions: Ten weeks of aerobic resistance training has a significant effect on reducing serum IL18 and increasing IL10 levels in postmenopausal women with fatty liver and can be effective in improving NAFLD by losing weight, improving body composition, and reducing insulin resistance.


A model of multi-functional ground source heat pump(MFGSHP)system integrated with cooling,heating and domestic hot water was developed.Taking a typical hotel in Changsha City as example,the techno-economic performances of MFGSHP system were studied.The heat balance of the soil around the borehole heat exchanger and the characteristic of energy consumption for MFGSHP system were analyzed.The energy consumption and life cycle economic analysis for MFGSHP system were compared to the conventional system(i.e.air source heat pump and electric water heater).The results show that the heat balance can be obviously improved by applying MFGSHP system,and the increase in soil temperature is reduced by 3.9℃compared to the common GSHP system with the same borehole length. The energy consumption of MFGSHP in hot summer and cold winter zone is the highest in summer,moderate in winter and the least in spring and autumn.Compared with the conventional system,MFGSHP can reduce 46%of annual energy consumption,and the saving of present cost value is in the range of 7%-40%and payback period ranges from 5 to 12 a.


Sustainable development of highway transportation and construction can be achieved through reasonably using natural resources and investment as well as giving attention to environment protection.


What is the correlation between the national and the international in economic science? How do the concepts of "economic thought," "economic science" (or "analysis"), and "economic policy" correlate? Does a Russian economic school exist as a particular area of world economic thought, inseparably linked with the historical, ethnocultural, and other specific features of the development of our country? All of these questions are at the center of the debate that was launched in the course of discussion of the paper by Academician L.I. Abalkin that was presented at the conference "The Russian School of Economic Thought: Past and Present."


The Kuznets hypothesis provides an association between economic growth and income inequality that takes the shape of an inverted U. Generally, such hypothesis is tested based on regressions involving income per capita and an index of inequality. This paper proposes an alternative analysis of the Kuznets hypothesis for the Northeast Region of Brazil based on a vector decomposition of income. All data are available on the Atlas of Human Development in Brazil - UNDP. In contrast to previous analysis, this analysis seeks to break down the per capita income in representative vectors of labor income and government transfers, allowing a deeper analysis of the factors that influence the relationship growth - equity. Moreover, also in contrast to previous studies, the analysis here follows the work of Huang et al. (2007), and tests the validity of the Kuznets hypothesis through the use of quantile regression. Our results validate the Kuznets hypothesis and suggest that the effects of labor income are more efficient than the effects of government transfers in reducing income inequality.


We studied a strategy for developing reproducible and stable 2D arrays of fractal micrometric gold nanoparticles arranged on silicon substrates. The combined use of electron beam lithography and molecular functionalization allowed us to finely control the shape of nanoparticle assemblies in designed areas. Atomic force microscopy measurements confirmed the regularity in spacing and size (i.e. area and layer number) of the obtained aggregates. Preliminary microRaman space resolved measurements were undertaken on a 100x100 μm2 2D array made up of 10 μm-spaced, 1 μm2 large clusters. The high surface enhanced Raman signal measured on the structure allowed us to point out a full correspondence in the periodical spacing both optically and topographically achieved. This may represent the basis to realize intriguing platforms for nano-optical investigation and towards an efficient high-sensitive multiplex sensing.


Recently, Haramati et al. published the findings of the CENTILE Conference 2015 on strategies to promote resilience, empathy and well-being in the health professions. We read these findings with great interest. This article, as well as previous work by Haramati and colleagues, has inspired us to design further research on decreasing mental distress prevalences among medical students (Van Venrooij et al. 2015), which we hope to discuss at the CENTILE Conference 2017. Haramati et al. describe that a solution to this problem lies in the medical curriculum environment (Haramati et al. 2017). We cannot agree more, that a change in curriculum is needed. Therefore, we would like to share our thoughts on what we believe is an important first step: acknowledging the problem. A common remark from people involved in medical education (e.g. senior clinicians) when we discuss our recent findings on burnout (Van Venrooij et al. 2015) is that ''Burnout is a mental condition which can solely occur among people who work. Medical students do not work, they study. Therefore, it is not possible for a medical student to be 'burned-out'.'' As this example illustrates, discussions on mental distress among medical students are often about semantics. We consider this a sign that the mentality towards educating medical students has not yet changed. These semantics-oriented discussions can be seen as part of the hidden curriculum: the lessons between the lines. In our opinion, for an effective decrease in mental distress prevalences among medical students and junior doctors, we first have to abandon the message that ''it's all part of the game.'' Burnout cannot be part of any game. In the words of Haramati and colleagues, as long as we do not invest in caring for the caregiver, the cost of caring may be high.


KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside the United States and Canada, today announced that the European Commission has approved KEYTRUDA, the company's anti-PD-1 therapy, in combination with pemetrexed (ALIMTA®) and plat inum chemotherapy for the first-line treatment of metastat ic nonsquamous non-small cell lung cancer (NSCLC) in adults whose tumors have no EGFR or ALK posit ive mutations. This approval, the first in Europe for an anti-PD-1 therapy in combination with chemotherapy, is based on data from the pivotal Phase 3 KEYNOTE-189 trial in patients with metastat ic nonsquamous NSCLC regardless of PD-L1 tumor expression status, which demonstrated a significant survival benefit for the combination of KEYTRUDA with chemotherapy as compared with standard-of-care chemotherapy alone – reducing the risk of death in these patients by half (HR=0.49 [95% CI, 0.38-0.64]; p<0.00001).


In recent years, in order to provide secure communication between Radio Frequency Identification (RFID) users different RFID authentication protocols have been proposed. In this paper, we investigate weaknesses of two newfound RFID authentication protocols that proposed by Shi et al. and Liu et al. in 2014. The Ouafi-Phan privacy model is used for privacy analysis. We show that these two protocols have some weaknesses and could not provide the security and the privacy of RFID users. Furthermore, two improved protocols are proposed that eliminate existing weaknesses in Shi et al.'s and Liu et al.'s protocols.


David Chalmers' widely acclaimed overview of the 1960s describes how the civil rights movement touched off a widening challenge to traditional values and arrangements. Chalmers recounts the judicial revolution that set national standards for race, politics, policing, and privacy. He examines the long, losing war on poverty and the struggle between the media and the government over the war in Vietnam. He follows feminism's "second wave" and the emergence of the environmental, consumer, and citizen action movements. And he explores the worlds of rock, sex, and drugs, and the entwining of the youth culture, the counterculture, and the American marketplace. This newly revised edition carries the story into the angry 1990s, in which the shadow of Vietnam still hangs over national policy and the social ethic of the sixties is overshadowed by a conservative counterrevolution against taxes, social programs, and the powers of the national government.


Dredge plume modelling forms an integral part of the supporting studies for EIA applications for both capital and maintenance dredging projects. The behaviour of dredge plumes is function of many variables, many of which are unknown at the time of undertaking the studies. As such engineering judgment, previous project experience (including engaging dredging contractors) and available literature form part of the tools used to characterize the behaviour of dredge plumes. This paper summarises two case studies where underwater disposal (using a vertical tremie pipe) of dredge material from a cutter section (CSD) was simulated in order to meet the regulatory standard at the edge of mixing zone.


Through an extension of the concept of scale invariance we construct two invariance transformations of the equations of gasdynamics: the first is a true Bäcklund transformation, and as such we expect that it should play an important role in the search for new cases of integrability; the other one affects the shape of the entropy profile, implying that the mathematical problems of isentropic and non-isentropic flow are, at least in some cases, equivalent. That property enables us to deduce the general solution in closed form, assuming a power-law entropy profile of the form P/ργ ≈ 1/M3γ−1, where M is the Lagrangian mass coordinate.


Following the second World War, governments and corporations recognized that the sciences of meteorology, hydrology and climatology could contribute to safety and efficiency in aviation, and advances in many other sectors of commerce and industry, and to the protection of human lives and property from natural hazards. To achieve those goals, National Meteorological and Hydrological Services (NMHSs) would have to expand their range of responsibilities and place greater emphasis on education and training in order to have capable and effective staff. Accordingly, enshrined in the WMO Convention signed by many governments in 1950 is the mandate to encourage research and training in meteorology and to assist in coordinating the international aspects of such research and training


Dose the follicular fluid-derived exosomes rejuvenate ovarian aging?

 Follicular fluid-derived exosomes efficiently rescued ovarian function in aged mice, which was achieved via transfer of miR-320-3p to granulosa cells and subsequent Foxq1 inhibition.

 The ovary enters the malfunctional aging phase earlier and faster than other organs and systems. Ovarian aging is mainly characterized by a progressive decline in oocyte quantity and quality, which ultimately leads to female infertility. Various therapies have been established to cope with age-related ovarian dysfunction, among which exosome-based therapy has been considered a promising strategy that can benefit ovarian functions via multiple pathways.

 Ovarian granulosa cells of young C57BL/6J mice (6-8 w) and old C57BL/6J mice (40 w) were cultured in vitro. The follicular fluid exosomes of young mice and the same amount of PBS were respectively injected into the ovarian sac of old mice.

 Cell proliferation and apoptosis were detected by CCK8, flow cytometry and Western Blot. Mitochondrial function was assessed by measuring mitochondrial membrane potential, ATP levels, mtDNA copy numbers. The number of ovarian follicles were observed by HE staining. Senescence and telomere related gene expression levels were detected by RT-qPCR. 2-cell rates and blastocyst formation rates were observed after in vitro fertilization. The model mice were directly cooped up to observe the pregnat and litter sizes.

 The follicular fluid exosomes from young mice can promote the proliferation of ovarian granulosa cells from old mice and improve mitochondrial function. When the follicular fluid exosomes from young mice were injected into the ovarian sac of old mice, the number of primordial and growing follicles in the ovaries of old mice were increased and the developmental ability of oocytes was improved.

 Findings in mouse.

 This study suggests that young follicular fluid exosomes may be involved in ovarian senescence by transferring miR-320a-3p targeting FOXQ1 into ovarian granulosa cells of aged mice.

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Results from a stability investigation using quad-focused laser differential interferometry (q-FLDI) and high-speed schlieren cinematography of hypersonic flow over a cooled and uncooled 5◦ half-angle cone are presented in this paper. The frequency and phase-speed of the largest-amplitude disturbance (largest N factor) as predicted by STABL and measured by FLDI or schlieren were in excellent agreement for the room-temperature cases and good agreement for the cooled-wall cases. A comparison between a cooled-wall and roomtemperature shot at nominally the same Reynolds number shows the interesting result of the later transition to turbulence for the cooled-wall shot. Our hypothesis is: cooled-wall cases have higher growth rates and higher most-amplified frequencies. Because there is less wind-tunnel noise at higher frequency, transition will occur at a higher Reynolds number.


In this paper, we are concerned with mortar element methods for the numerical solution of the eddy currents equations based on domain decompositions on nonmatching grids using individual subdomain discretizations by the lowest order edge elements of Nedelec's first family. The main results are optimal a priori error estimates of the global discretization error and the Lagrange multipliers that take care of the weak continuity constraints on the tangential traces across interior subdomain boundaries. These estimates are derived under moderate regularity assumptions.


Abstract : This report presents design criteria for laminated rubber seismic isolation systems for use in construction of Navy essential buildings. Base isolation has been shown to limit seismic motions transmitted to structures and is effective in reducing damage. The design criteria, applicable only to structures having structural detailing as required in Seismic Zones 3 and 4, utilizes two structural load levels of performance associated with each. A structure designed according to these provisions will withstand the most probable maximum earthquake with inelastic demand ratios of 2.0 in beams and 1. 25 in columns. Keywords: Seismic design; Base isolation; Structural response. (SDW)


A MADS-box gene named DkMADS1 was cloned from Yangfeng persimmon flowers(GenBank accession No.DQ412058).The sequence of complete DkMADS1 cDNA gene is 1 193 bp,with an ORF encoding 249 amino acids.The deduced protein contained conservative MADS domain and semi-conservative K domain.It shared highly homology to other MADS-box proteins from different species.RT-PCR analysis showed that DkMADS1 gene was expressed in sepal,petal,ovary of Yangfeng persimmon and stamen of Zenjimaru persimmon.


obstruction and is rarely reported in the literature as a complication of Meckel's diverticulum. Internal hernias in this setting have been observed when a mesodiverticular band has trapped loops of small bowel or small bowel has volved around the diverticulum or the band. The ileum can also herniate through a congenital defect in the mesentery of a Meckel's diverticulum. We believe this is the first reported case of a small bowel obstruction where a Meckel's diverticulum itself has herniated between another loop of small bowel. Our patient's history and examination were suggestive of small bowel obstruction. He underwent CT scanning while in the emergency department that confirmed the diagnosis, but not the presence of an internal hernia or Meckel's diverticulum nor confirmation of a closed loop obstruction. The literature suggests that patients presenting with a Meckel's diverticulumrelated obstruction have it identified on CT approximately 50% of the time. Small bowel obstruction caused by internal hernias are not amenable to conservative management. In this instance, radiological investigation did not clarify the pathology and diagnosis was made at laparotomy. Surgical management was guided by the patient's clinical deterioration. Internal herniation of a Meckel's diverticulum is an extremely rare cause of small bowel obstruction but presence of a symptomatic Meckel's diverticulum should be considered in the differential diagnosis of small bowel obstruction.


Describes how cancer care is structured and explains rationale and components of multidisciplinary teams. This runs through cancer care from diagnosis to terminal care and has resulted in better quality and outcomes for patients


The goal of this article is to introduce the notion of industrial linguistic heritage into the study of industrial heritage. By combining viewpoints of cultural heritage research and language studies, the article opens new insights into the identities and cultural resources of industrial communities. The linguistic heritage of industry is investigated in the light of two case studies from selected linguistic landscapes of Varkaus, a small industrial community in eastern Finland. The case studies illuminate both multilingualism of the industrial community as industrial linguistic heritage and language as a means to verbalize and commemorate the industrial past of the community. The examination of the linguistic landscape data shows that language is an important strategic means to verbalize the past, to restore shared histories and participatory experiences, and to carry out commemorative identity work in the industrial heritage community.


From the species generated by photoexcitation of ArH–tetranitromethane charge transfer complexes, ArH˙+, trinitromethanide ion and nitrogen dioxide, the reaction between ArH˙+ and trinitromethanide has been shown to be significantly faster than that between ArH˙+ and nitrogen dioxide.


Deep generative models are being increasingly used in a wide variety of applications. However, the generative process is not fully predictable and at times, it produces an unexpected output. We will refer to those outputs as out-domain examples. In the present paper we show that an attacker can force a pre-trained generator to reproduce an arbitrary out-domain example if fed by a suitable adversarial input. The main assumption is that those outputs lie in an unexplored region of the generator's codomain and hence they have a very low probability of being naturally generated. Moreover, we show that this adversarial input can be shaped so as to be statistically indistinguishable from the set of genuine inputs. The goal is to look for an efficient way of finding these inputs in the generator's latent space.


In this paper, we aim to clarify the effectiveness of a thermal‐based sensor, which applies image recognition technique to thermal image to measure occupancy state. Our experiment, which was conducted at a single private office over 8 days, evaluated both energy‐saving rate of occupancy control and F‐measure, which is the comprehensive metric of measurement accuracy. The thermal‐based sensor increased the F‐measure and energy‐saving rate by 2.23% and 27.91%, respectively, compared with the passive infrared sensor, which measures the occupancy state on the basis of change in infrared temperature. Compared with an image‐based sensor, which applies image recognition technique to visible image, it can provide high privacy and security preserving capability and detect occupants under completely dark environment. However, the F‐measure and energy‐saving rate were decreased by 3.13% and 19.07%, respectively. Further results and discussion are included herein toward analysis and improvement of the thermal‐based sensor. © 2022 Institute of Electrical Engineers of Japan. Published by Wiley Periodicals LLC.


In this article, a segmentation approach for cloud detection in Meteosat Second Generation (MSG) multispectral images is proposed. The proposed algorithm uses recursive segmentation that dynamically reduces the number of classes. This algorithm consists of two steps. First, an initial segmentation of the image is obtained using local fuzzy clustering. The clustering algorithm is formulated by modifying the similarity measure of the standard fuzzy c-means (FCM) algorithm. The new similarity function includes the spectral information as well as the homogeneity and spatial clustering information of each considered pixel. In the second step, a hierarchical region-merging process is used to reduce the number of image clusters. At each iteration, the segmentation algorithm proceeds with a new partition until the final result of the segmentation is obtained. The proposed method has been tested using synthetic and MSG images. It yields a compact and coherent segmentation map, with a satisfactory reproduction of the image contours. Moreover, the different types of clouds are well detected and separated with appropriate accuracy.


This paper mainly studies the content of Internet of things data mining under the infinite communication mechanism. Firstly, it discusses the theoretical basis of infinite communication mechanism, and then analyzes the function realization of Internet of things data mining based on infinite communication mechanism. Data source conversion module is mainly divided into three aspects. Hope to provide reference for the researchers who pay attention to this topic.


The requirement of the modern computer system is a dedicated and very high speed unique multiplier unit for signed and unsigned numbers. The work mainly deals with in improving multiplication process by using Redundant Binary Technique. The redundant binary in design of high speed digital multiplier is beneficial due to high modularity and carry free addition. Generally, in high radix modified algorithm the partial products are reduced in multiplication process. But it yields complexity in producing in generation of hard multiples. Therefore compressors are used for the addition of the partial products, which reduces the carry propagation delay. Thus we achieve faster multiplication compared with the existing multipliers.


This paper presents preliminary, experimental results of a new, hybrid method of increasing the surface roughness of metal objects. In this new approach, metal objects are melted with a mobile laser beam while they are being rotated. A vibration generator provides circular vibrations with an amplitude of 3 mm, and the vibration plane is perpendicular to the moving laser beam. The melting tests were performed using flat carbon steel samples at a predetermined frequency of circular vibrations. The effects of laser power and laser beam scanning velocity on the melted shapes were studied. All laser melting procedures were performed at a vibration frequency of 105 Hz. The melted samples were subjected to microscopic evaluation and the R a parameter, which characterises mean roughness, was measured using a profilometer. Melting metal samples with physically smooth surfaces (R a = 0.21 µ m) resulted in surface structures of varied roughness values, with R a ranging from 5 µ m to approximately 58 µ m. The studies were undertaken to employ this technology for the purpose of passive heat exchange intensification of heating surfaces in practical applications.


The purpose of this article is to give the algebraic background of the shifting theory developed by Kalai [26], [27]. The reader who is interested in the combinatorial aspects of the theory should consult Kalai's survey paper [26] and his article in this volume. In the present article we are mainly interested in the behaviour of graded Betti numbers under the operation of algebraic shifting. Algebraic shifting is intimately related to the theory of generic initial ideals. In Section 1 we recall some of the basic facts of this theory. The next section is devoted to the study of stable and strongly stable ideals since generic initial ideals are of this kind, provided the base field is of characteristic 0. In Section 3 we describe the Betti numbers of stable and squarefree stable ideals, and in Section 4 the Cartan complex which provides the graded minimal free resolution of the residue class field of the exterior algebra. For the theory of squarefree monomial ideals, which is significant for combinatorial applications, it is necessary to study graded ideals, graded modules and their resolutions over the exterior algebra. In Section 5 we explain how the graded Betti numbers of squarefree monomial ideals over the exterior and symmetric algebra are related. The following two sections are devoted to the proof of a theorem on extremal Betti numbers by Bayer, Charalambous and S. Popescu [12], as well as to the corresponding theorem in the squarefree case by Aramova and the author [4]. In Section 8 we describe various shifting operators and apply the homological theory of the previous sections. Symmetric algebraic shifting and a theorem of Bjorner and Kalai [15] are applied in Section 9 in order to deduce a theorem on superextremal Betti numbers. In the final section extremality properties of lexsegment ideals are briefly sketched.


The motivation of this paper is to propose a simple and reliable method to identify on-road vehicle events, particularly in the driving situations. A content rhythm is extracted by applying a virtual line lies on the same position of each frame. Thereupon a simplified representation of a continuous video is to record the temporal information of vehicle status. Thus, vehicle situations such as lane changing, vehicle passing, safe distance and zigzag driving can be detected instantly by analyzing the statistical characteristics of content rhythm. The proposed method can not only prevent accidents but also improve the traffic safety by monitoring the on-road vehicle status. Experimental results show the proposed method is reliable for vehicle event detection.


OBJECTIVE
Demonstrate the use of wide-field optical fluorescence as an adjunctive examination in a clinical routine to oral diagnosis.

BACKGROUND DATA
Use of wide-field optical fluorescence in the oral cavity has been restricted to topics related to the detection and diagnosis of oral cancer.

MATERIALS AND METHODS
In a regular medical appointment, a 58-year-old female patient, without any complaint or oral symptom, underwent the complementary examination by wide-field optical fluorescence. A device with high-power light-emitting diode emitting light centered at a wavelength of (400 ± 10) nm and maximum irradiance of (0.040 ± 0.008) W/cm2 was used for fluorescence visualization.

RESULTS
We report the location of a firearm projectile, intraosseous, in the maxillary tuberosity using wide-field optical fluorescence.

CONCLUSIONS
It is evidenced that wide-field optical fluorescence, within a clinical routine, can provide relevant images and data, with an immediate result, without the use of ionizing radiation, enabling an efficient oral diagnosis.


A general synthetic approach has been developed for heterocyclic prostaglandins (PGF2α type) starting from the key intermediate (6). (±) 6 was obtained from (±) -Corey lactone. The key intermediate (±) 6 was, in turn, converted in to several new heterocyclic prostaglandins consisting of furan and thiophene moieties in ω-side chain in two to three steps. Horner–Wadsworth–Emmons reaction and Grignard reaction as the key reactions in these transformations.


Phyllis Weliver's monograph Mary Gladstone and the Victorian Salon: Music, Literature, Liberalism examines Victorian salon culture through the lens of Gladstone's own socio-political, cultural, educational and religious background and thus makes a valuable contribution to both Gladstone biography and salon research. As socio-cultural institutions, salons had a huge political, artistic and scientific impact on nineteenth-century discourse throughout Europe. Their attempts at challenging social, religious and educational boundaries were welcomed by the (usually female) salon hosts, their regular attendees, and their fluctuating circles of visitors. Salons, in the broadest sense, are regular social gatherings in a private space that encouraged a wide range of activities: philosophical and/or political discussion, the art of conversation, music, poetry and drama recitals, dance, tableaux vivants, painting, board games and quizzes, tea and food sampling, and crafts. While some of these pastimes were regional in nature and/or depended on each individual salon's purpose and the host's preferences, it was the arts of conversation, music, and poetry which apparently were present at most gatherings. When considering salon research to date, three problems emerge. First, music performed in salons is not primarily part of compositional history but, rather, is both reason for and result of cultural practice. Thus, music that was heard in salons should be considered within the context of cultural history rather than solely through the lens of music and/or compositional history. However, a large part of nineteenth-century salon repertoire is unknown today and its examination is not always easy due to accessibility issues. Second, salon culture primarily has been researched with respect to such important cultural centres as Berlin, Paris or Weimar. However, much can be learnt from the scrutiny of certain socioculturally less sophisticated locations. Only recently have musicologists and cultural historians started to pay attention to seemingly less significant regions. These examinations have already proven that, within their own contexts, these centres had a remarkable cultural reverberation. Third, many of these early studies


This paper is an evaluation of three different chronological placements of the Pinto Period in light of obsidian hydration readings from the Stahl, or Little Lake, site (Harrington 1957; Meighan 1981) and the Awl site located at the west end of Drinkwater Basin on Fort Irwin (Fig. 1). The three chronologies selected are representative of different views concerning the beginning and ending dates for the Pinto Period and its cultural relationship to the earlier Lake Mojave Period (Fig. 2). Wallace's (1962) chronological placement of the Pinto Period sets a terminal date of A.D. 1 and an initial date of 2500 B.C., with a cultural hiatus separating the Lake Mojave and Pinto periods. Bettinger and Taylor (1974) place their Little Lake (Pinto) Period between 1200 and 4000 B.C., immediately following the Lake Mojave Period. Warren and Crabtree (in press) date the Pinto Period between 2000 and 5000 B.C., immediately following the Lake Mojave Period. These proposed beginning and ending dates for the Pinto Period, and the presence or absence of a preceding cultural hiatus, can be evaluated with data that include obsidian hydration measurements from the Little Lake and Awl sites, and available radiocarbon dates pertaining to the outset of the Gypsum (or Newberry) Period


A series of π-extended N-arylpyrrolo[3,4-d]tetrathiafulvalenes, N-aryl-2-[4,5-bis(ethylthio)-1,3-dithiole-2-ylidene]-(1,3)-dithiolo[4,5-c]pyrroles, (3a-d) were prepared via cross-coupling of 4,5-bis(ethylthio)-1,3-dithiol-2-one (12) with N-aryl-(1,3)-dithiolo[4,5-c]pyrrole-2-thiones (11a-d). The latters were obtained by the reactions of 4,5-bis(bromomethyl)-1,3-dithiole-2-thione (8) with aromatic amines (9a-d). Electrochemical behavior of compounds (3a-d) was studied by means of cyclic voltammetry. It was found that all these compounds (3a-d) have comparable to or lower half-wave potentials than those of N-alkyl-pyrrolo[3,4-d]tetrathiafulvalenes (2a-c).


This paper mainly investigates multi-modal shortest path problems in fuzzy environment, in which the arc travel times are represented by fuzzy variables. Within the framework of fuzzy programming, a chance-constrained programming model is formulated, and then its corresponding crisp equivalent is given. It is noted that we introduce transfer arcs to represent the travel mode change for the convenience of the model's establishment. Finally, some numerical examples are given to show the applications of the proposed models.


The authors present the ways to resolve the problem of continuity in organizing the practices of bachelors of health and safety education. The authors demonstrate the directions of continuity during the process of organization and implementation of educational and work experience internship. As a result, it is revealed that continuity during practices can be realized allowing for the relationship between the goals and objectives of bachelor education for practice-oriented activities; in the process of mastering the theoretical material of the disciplines of the Methodical module; during the process of structuring various types of professional activities of students. The main types of practice are educational (introductory, subject-content) and work experience internship (pedagogical, trainee). The competencies obtained by bachelor students in the course of internships are presented. The types of activities that contribute to the acquisition of the professional competence necessary for conducting the educational process on the basics of health and safety education in educational organizations of various types are described.


In this study, we use self developed questionnaire about belief to measure the present mass belief among a sample of 745 people. The result of the analysis shows: peoples social believes vary with their occupations and their ages. This means that we must focus belief education on special age and occupations.


Zellner has proposed a novel methodology for estimating structural parameters and predicting future observables based on two moments of a subjective distribution and the application of the maximum entropy principle-all in the absence of an explicit statistical model or likelihood function for the data. He calls his procedure the 'Bayesian method of moments' (BMOM). In a recent paper in this journal, Green and Strawderman applied the BMOM to a model for slash pine plantations. It is our view that there are inconsistencies between BMOM and Bayesian (conditional) probability, as we explain in this paper.


Rationality is often related to optimal decision making. Humans are known to be bounded rational agents. However, recent advances in computing, and other scientific and technical fields along with large amount of data have led to a feeling that this could result in extending the limits of bounded rationality in humans through augmented machine intelligence. In this paper, results from a computational model show that as more agents reach global optimality, faster with enhanced computing, etc., solving the same problem independently, this leads to accelerated"tragedy of the commons"due to quicker resource consumption. Thus, bounded rationality could be seen as blessing in disguise (providing diversity to solutions for the same problem) from sustainability standpoint.


Dr Mike Shooter poses an enigmatic media question. In April 1987, in a back-street bar in Cardiff, the rebel regime at Radio Wales were plotting a coup. Their secret weapon was a daily magazine programme of music and current affairs called Streetitfe . The would-be front-men, Ray Gravell (British Lions centre) and Frank Hennessy (Cardiff-Irish folk singer) had just persuaded the Editor that it needed an 'agony uncle' … when I walked in. By April of this year, Streetitfe had gone out for the last time. So what did it achieve, this seven years of public problem-solving in which the only quality-control was the redoubtable Mrs Prosser9s sensitivities? There were teething troubles, of course; some lessons learnt, perhaps; and a lot of tightropes walked, not always with a safety net. Of the teething troubles, regularity was the first. The BBC began by treating me as a moveable feast.


Brine pools—hypersaline, low-oxygen waters deadly to many forms of ocean life—can experience waves hundreds of meters high when hit by a landslide, potentially overspilling their deep-sea basins.


The civic culture can embody a city's soft strength, and its development can play a very important role in a city's entirety construction.This article takes the material culture and the energetic cultural two stratification planes as a breakthrough point, focusing on Dalian civic culture's superiority and its experiences, and also pointing out the problems during Dalian civic culture construction ,in order to study city's development in civic culture plane, and discussing which style a competitive power and vigor city must have.The propose is to promote sustainable development, to enhance city soft strength, finally give experiences in civic culture to other cities.


Objective To grasp the hygienic situation of antibacterial lotion sold in the market,and to provide the basis for health supervision and consumption guide.Methods We detected and appraised the antibacterial lotion in accordance with the Appendix A and B of the National Standards GB15979-2002(Hygiene Standards of Disposable Hygiene Products).Results Nineteen samples of antibacterial lotion were randomly selected from the markets,with the eligible rate of 73.16%(12/19).The total number of bacterial colonies,the total number of fungal colonies,pathogen Pseudomonas aeruginosa,and the bactericidal rate were the main unqualified targets.Conclusions The quality of antibacterial lotion sold in the markets is uneven,and it is necessary to further strengthen market supervision.


Context Preoperative evaluation is aimed at prevention of complications and risk stratification. Routine testing should be abandoned in favour of selective ordering according to contemporary guidelines. This study was conducted to calculate the possible economic impact of a Web-based preoperative diagnostic guideline prior to its implementation in the state of Salzburg, Austria. Design Prospective observational cohort study. Setting The study was carried out in a secondary care hospital in Salzburg (Schwarzach). Participants and main outcome measures Data from 1363 consecutive patients scheduled for elective surgery from 1 September to 30 November 2007 were collected: demographic data, medical history, surgical procedure, preoperative tests and findings. The data were entered into the preoperative diagnostic guideline software and the guideline-adherent recommendations were compared with the investigations performed, with special attention to duplicate examinations. Results A total of 5879 tests were documented and analysed. In 65.6% of patients, guideline-adherent evaluation would have indicated only basic requirements, but 3380 additional tests were carried out. In all, 81.7% of tests were identified as nonadherent based on the preoperative diagnostic guideline software and 226 duplicate tests were performed. Possible savings per 1000 patients would be &OV0556;26 287 if preoperative diagnostic guideline recommendations were followed exactly and &OV0556;1076 if duplicated tests were avoided. According to a generalised linear model (Gamma model), an increase of 1 year of age leads to an increase of costs by a factor of 1.020. Conclusion These data indicate a considerable potential for improvement in process quality and cost reduction by using structured preoperative assessment with computer-assisted implementation of a guideline.


Optically active 2-methylchroman-2-carboxylic acid derivatives as new chiral dopants for nematic liquid crystals were prepared from optically active 6-benzyloxy-2-methylchroman-2-carboxylic acid, which was newly synthesized and resolved by diastereomeric salt formation method. The helical twisting power of the dopants was determined and the relationship with their structures were studied.


The contribution to management philosophy is to develop a postcolonial storytelling theory that foregrounds ontology. We do this by drawing together parallel developments in agential realism, quantum physics, and tribal people"s storytelling. We argue that these developments resituate the hegemonic relationship of narrative representationalism over material storytelling practices. Implications are two-fold. First, it dissolves inherent dualisms presumed in the concept of interaction among entities like actor-structure, subject-object, discursive-nondiscursive in favor of a profound ontology of entanglement and intra-action of materiality and discourse. This implies a democratization of material and human voices in that agency does not belong solely to the human domain. Second, postcolonial phenomena are understood as the results of entangled genealogies in which plural voices are present. This includes an awareness of material storytelling and antenarrative resistance and contestation to imperial and colonizing narratives but also the intraaction among material storytelling and master narratives and the spatial alignment among them.


A power conditioning system combing with photovoltaic array, sodium-sulfur battery and flywheel energy storage system is presented, which is used to improve the power quality of the low-voltage gird in China. All the three energy sources are connected to the common DC bus by different power electronics interfaces. The functions and specifications of the system are studied, and then the selections of appropriate topologies for those power electronics interfaces are investigated in details.


Water is one of the bestowed bounties created by God on His worldly creations. It is an important natural resource required for survival of life and plays an important role in the economic wealth of nations. Rapid urbanization and industrialization, intensive agriculture, changes in human life styles etc., have created new demands of water. Haphazard exploitation of surface and subsurface water leads to severe water scarcity and environmental degradation. Spatial and temporal variation in rainfall has further aggravated the problem. The major challenge before all the nations is to supply adequate drinking water especially in rapid growing towns and cities. Identification of sources of water supply, their conservation, economical and equitable use of water has become a matter of utmost importance.


Multicarrier modulation possesses several properties which make it an attractive approach for high speed copper wire communication networks. Among these properties are the ability to efficiently access and distribute multiplexed data streams, and a reduced susceptibility to impulsive, as well as to narrowband channel disturbances. In digital implementations of multicarrier modulation, subcarrier generation and data modulation are accomplished digitally using orthogonal transformations of data blocks. These implementations are particularly efficient with regard to bandwidth utilization and transceiver complexity. In this paper, we present a form of digital multicarrier modulation which we refer to as overlapped discrete multitone, or discrete wavelet multitone (DWMT), modulation. For DWMT modulation, which is based on the application of M-band wavelet filters, the pulses for different data blocks overlap in time, and are designed to achieve a combination of subchannel spectral containment and bandwidth efficiency that is fundamentally better than with other forms of multicarrier modulation. We show that, as a result of the spectral containment feature, DWMT gives a high level of robustness with regard to noise environments and channel variations that are encountered in practice


ABSTRACT The interactions between sodium indomethacin and chloride salts of four quaternary ammonium compounds were characterized. Investigations involved conductimetric studies at concentration regions wherein ion-pairs exist in equilibrium with the solution of participating ions. Iontophoresis was also utilized to investigate the phenomenon of ion-pairing. Characteristic of large molecules, extremely high levels of ion-pair association constants and low degrees of dissociation were obtained.


A new genus and species of pantothere (Kuehneotherium praecursoris) from the Welsh Rhaetic is defined, named and briefly described. Its molars are tritubercular, with a lingual cingulum in the uppers and a tiny talonid with a large hypoconulid in the lowers. The molars and premolars do not appear to intergrade. There were between nine and eleven lower posteanines; at least five of these were premolars. The number of upper postcanines is unknown; it is unlikely to have differed by more than one from the number of lowers. The dentary terminated in a, well-developed condyle, there was no angle, and there is evidence of a full complement of accessory jaw bones including a coronoid. A new family Kuehneotheriidae is established for Kuehneotherium and related forms. The pantotheres are divided among three suborders: the new suborder Amphitheria, which includes the families Kuehneotheriidae, Amphitheriidae, Peramuridae and Paurodontidae; the Dryolestoidea and the Symmetrodonta.


Acknowledgements Introduction. Before Burroughs: The Prehistory of the Cut-Ups The Origin and Theory of the Cut-Ups Early Successors: Pelieu, Giorno, Weissner Inter-Section. The Mutations of Burroughs: Revising the Cut-Up Technique Kathy Acker: Plagiarism and Adaptation - From Cut-Up to Cut-and-Paste Stewart Home: Pulp, Parody, Repetition and the Cut-Up Renaissance Further Mutations: The Cut-Ups in the New Millennium Works Cited Index


In this paper, indium zinc oxide (IZO) thin films were deposited on a quartz substrate by radio frequency magnetron sputtering. Surface analysis showed that the IZO film deposited under a flow ratio of 10% oxygen has the smoothest surface, and this was determined to the optimum parameter for the fabrication of the metal-semiconductor-metal (MSM) photodetector. In order to improve the response characteristics of the device, 3-aminopropyltrimethoxysilane (APTMS) was deposited onto the IZO film to improve its surface state, which could, in turn, reduce the negative effect of vacancies and suppress the leakage current path for the IZO photodetector. Following APTMS modification, the dark current of the IZO photodetector decreased by nearly an order and the rejection ratio increased from 325 to 728.


A system allows to carry out simultaneous analysis and detections of a factor in a plurality of biological samples. It is characterized by the combination on one hand of a plate comprising a set of cavities distributed in a plurality of distinct series and rows, said plate being made of a material having no adsorption capacity for the factor to be tested for and, on the other hand, of a comb comprising teeth (4) of which the spacings allow to insert them simultaneously in as many cavities of the plate, the teeth of said comb being themselves made of a material retaining or capable of retaining, particularly by absorption or adsorption, either the factor or the reactant for detecting said vector.


The Primary Education Improvement Program (Science) developed in Nigeria from 1970–1980 adopted a "process approach" to the teaching of science for children in Classes One and Two of primary school. In that insufficient formative data were available a study was organized to evaluate the attainment of the program's major objectives in terms of the children's ability to practice process skills. The study also attempted to measure children's interest, active participation and understanding of the lessons, as well as the availability of materials and ease of preparing and teaching the lessons for the teachers. Data were collected by means of teacher opinionnaires and a children's test to measure the attainment of process skills. The teachers who completed the opinionnaires rated the program as successful in terms of all the measured criteria. Children in the experimental and control groups were tested and their performances were compared. The results indicated that there were some significant differences in total test scores in favor of the experimental group after one year of primary school but none after two years. The program, though highly rated by teachers, did not produce the intended changes in children's behavior.


The present invention is a protein trans production of the novel peptides having the amino acid sequence shown in SEQ ID No. 1 domain; case relates to (PTD Protein transduction domain), and its purpose, be a peptide of SEQ ID NO: 1 of the present invention as PTD, protein , a peptide, DNA, such as a biological molecule (target substance), there is an advantage that can be easily introduced into a high yield into a cell.


In what must be one of the most memorable openings in fiction, Benito Pérez Galdós begins El amigo Manso (1882) with these words: "Yo no existo..." and ends the opening paragraph with "no soy, ni he sido, ni seré nunca nadie" (7). Dramatized author Galdós, already an author of 30 novels, approaches this non-entity Manso to help him write another novel. Manso agrees and Galdós creates him by plunging the idea of him into ink, putting it on paper, setting the paper aflame, and placing it all in a flask, from which Manso emerges out of a red flame "convertido en carne mortal" (9). Galdós creates this "mortal flesh" from an idea that he writes into being. Miguel de Unamuno similarly wanted his reader to be able to perceive the life force within his characters (his "agonists"), which came from the characters' desire for life. no amount of attention to the process of writing could enliven his characters; thus, while Unamuno employed the metafictional mode – most famously in Niebla (1914) –, he did so only to serve his idealist and existentialist interrogation of the nature of reality and to explore art as a way to (re-)create and enhance reality. nearly a century later, José María Merino would write Los invisibles (2000), with its second part entitled "ni novela ni nivola," which focuses on the generation of the story that we have read in the first part. Like Unamuno, Merino will emphasize the co-dependence of creator and created, author and reader, reader and protagonist in the creation of reality; how-


In commonly used Pareto optimality the notions reference, preference, convexity and efficiency are interrelated and of great importance. It is shown that the usual notion of convexity on the base of straight lines is not consistent with Pareto optimality. There are many possibilities to reach all efficient points by using a parameterized set of compromise criteria.

Especially important for the decision maker's goal is to describe local wishes by corresponding reference points. It is useful to describe these reference points by preference levels or local utility fields. The method of direction diagrams helps to introduce the decision maker's imagination. The penalty scalarization method proves as a special case of direction diagrams. Direction diagrams serve for the design of good seeking procedures for efficient points expressed in terms of the control space.


The editors of the Mirrlees Review asked us to evaluate the UK VAT and the European Union VAT Directive and compare them to the New Zealand VAT model, which is called GST (Goods and Services Tax). At first sight, this brief might seem strange. After all, the VAT is a European invention that has swept the world, now applying in around 150 countries while GST is merely a more recent, modified European VAT. Yet, for the whole life of the New Zealand GST, international VAT experts, including from Europe, have made favourable comparisons between the old European VAT model and the GST model.1 In many cases, these comparisons have concluded that the changes that New Zealand made when introducing its VAT in the mid-1980s were improvements on the European model – a case of same wine, new bottle. Countries seeking to introduce VAT have often been advised to consider New Zealand's approach, and many countries have done so.


The present invention, in the outer skin, little or no defective, honeycomb ceramic articles, and to provide a manufacturing method thereof of the article. Minimizing cracks in thin wall and ultra-thin wall cordierite honeycomb articles, and / or discloses a method of eliminating. Advantageously, the present invention, porosity, thickness, and by optimizing the skin characteristics, such as pore size distribution, of the epidermis, which is formed during the preparation of thin-wall and ultra-thin wall cordierite honeycomb articles to prevent cracking.


Manures are believed to be an effective treatment to reduce Al toxicity in acidic soils. A pot experiment was conducted to study the effect of feedlot manure (FM) and poultry litter (PL) on soil Al status and wheat growth. Custer, an acid susceptible wheat cultivar (Triticum aestivum L. var. Custer), was planted in a manure amended Teller (fine-loamy, mixed, thermic Udic Argiustoll) fine sandy loam soil and relationships between soil pH, organic carbon (OC), and P added in the manure, 0.01 mol L-1 CaCl 2 extractable Al (Al CaCl2 ), 1.0 mol L-1 KCl exchangeable Al (Al KCl ), and wheat growth were investigated. An acidic surface soil was mixed with five levels of FM and PL and incubated for 30 d in an environmentally controlled growth chamber before wheat was planted. Wheat was grown for 35 d and harvested for aboveground dry matter. Both PL and FM increased soil pH, reduced Al CaCl2 and Al KCl , and increased wheat biomass. Wheat biomass was positively correlated with soil pH (r = 0.76), OC added (r = 0.63), and P 2 O 5 added (r = 0.87) but was negatively correlated with Al CaCl2 on (r = -0.83) and Al KCl (r = -0.87). Path analysis showed significant direct effects (p 0.05) but the indirect effects of OC added and P 2 O 5 added were important contributors to the correlations between wheat biomass and soil pH, Al CaCl2 , and Al KCl . These two animal manures have the potential to reduce Al toxicity in acidic soils but need to be further evaluated at a field scale.


Background: Internet addiction (IA) has emerged as a serious threat to the mental health of young individuals. Objectives: The present study aimed to test the effects of cognitive-behavioral group therapy (CBGT) on controlling Internet addictive behaviors and improving levels of depression, anxiety, and stress among nursing students in Morocco. Methods: A total of 60 nursing students participated in the study based on convenience sampling and were then randomly assigned to the intervention group (n = 30) and control group (n = 30). The intervention group received 8 sessions of CBGT, unlike the control group. The Internet Addiction Test and the Depression, Anxiety, and Stress Scale were used as the pretest, posttest, and 3-month follow-up tests to determine participants' levels of IA, depression, anxiety, and stress. Analysis of covariance (ANCOVA) was applied to assess the effects of this therapeutic intervention. Results: The results showed that following the CBGT program, the intervention group showed a reduction in IA (P < 0.05), depression (P < 0.05), anxiety (P < 0.05), and stress (P < 0.05) scores. Conclusions: Cognitive-behavioral group therapy was observed to be more effective in improving the cognitive, psychological, and behavioral skills of Internet-dependent nursing students, thereby reducing levels of depression, anxiety, and stress. This outcome opens up important perspectives in the field of health sciences education by considering this approach as a preferred way to promote students' mental health in this context.


The paper provides an overview of the wider social atmosphere from the plebiscite to the first days of 1991, when it was finally clear that the only possible solution for Slovenia was to leave Yugoslavia. Although there were still individual voices that allowed for the possibility of confederation, the political and economic situation in the country deteriorated to such an extent that Slovenia had to think primarily of protecting its own interests. The author presents the prevailing atmosphere in Slovenia based on newspaper sources. Despite some differences of opinion, the period around the plebiscite united the Slovenes, which was also indicated by a high voter turnout in the plebiscite and a high percentage of votes for an independent country, the Republic of Slovenia. Politicians, regardless of their party affiliation and differences, were aware that measures for the implementation of the plebiscite had to be initiated immediately after the plebiscite and that Slovenia's position in negotiations with the federal authorities and other republics had to be consolidated.


In a recent article Aharony and Swary considered the synchronous nature of earnings and dividends announcements in examination of the information content of dividend hypothesis. They concluded that their results support the information content of dividends hypothesis—that announcements of changes in dividends provide information beyond that contained in quarterly earnings announcements. A shortcoming of the Aharony and Swary study is that it considers only dividend and earnings announcements that occur at least 11 trading days from each other. In fact, as their Table I indicates the majority of such pairs of announcements occur within ten days of each other. Further, approximately one‐half of their observations of earnings and dividends announcements are separated by at least 21 trading days (close to one calendar month). These considerations lead one to wonder how synchronous their announcements are and whether their results can be generalized to earnings and dividend announcements that actually occur in close proximity to each other.


Swedish building and construction work expanded very fast both technically and industrially during the two decades following 1950, domestically first, later also abroad. The 1980s has been a period of stagnation and towards the end a push towards intensified research and development. With the 90s ahead, great changes are taking place. The continued development of the construction industry must to an increasing extent be adapted to international competition and foreign market demands. This paper briefly describes the organization and directions of current Swedish construction technology research and development.


Kidney is the most vital excretory organ. The nephrons filter a large amount of blood and eventually form urine. But sometimes there may be abnormality in the whole process which can lead to various disorders.Ayurvedic system of medicine has elaborated whole diseases into two distinct pathology –Mutrakriccha and Mutraghata. They are again divided into various subtypes and accordingly medications are prescribed. Susruta and Charaka described different Mahakashayas which includes ten drugs in each groups to treat those diseases. Concept of diuretic is not new to Ayurveda. Modern medicine has classified kidney diseases according to the site and nature of the disease. Their classification is very distinct. Modern investigations like USG, CT scan can spot the exact location of the disease very smoothly. Yet Ayurveda has a lot of role to play in kidney disorders of modern era.


In the last years, the scientific interest on job crafting within the Job demands-resources theory has been increased. The paper aimed to examine the role of job crafting in the relationship between self-efficacy and performance at work. Based on Job demands-resources theory, we hypothesized that employees with higher levels of self-efficacy would be most likely to make proactively changes in their own jobs in order to perform well. Specifically, we hypothesized that job crafting may mediate the positive effects between self-efficacy and work performance and organizational citizenship behaviours. Participants were 361 employees of different Italian organizations. Results from SEM showed the positive effect of self-efficacy on job crafting, work performance, and organizational citizenship behaviours. Furthermore, job crafting partially mediated the relationship between self-efficacy and work performance and totally mediated the relationship between self-efficacy and organizational citizenship behaviours. Findings suggest that job crafting can play a crucial role in the influence of personal resources, as self-efficacy, and the performance at work.


The National Rotavirus Reference Centre (NRRC) undertakes surveillance and characterisation of rotavirus strains causing epidemics of severe diarrhoea in young children throughout Australia. There are currently fourteen laboratories contributing data and rotavirus specimens for the characterisation of representative rotavirus serotypes. The NRRC is happy to receive notifications of rotavirus outbreaks Australia-wide. Rotavirus reports have been received from most Australian centres for the period 1 June to 31 August 2000. All Australian capital cities with the exception of Adelaide, Brisbane and Hobart experienced a drop in rotavirus reports compared with the same time last year. 1 Perth in particular had a quiet season reporting 36 rotavirus cases in August 2000, compared with 65 in 1999. This lower incidence was also noted in Melbourne, with 32 cases in August 2000, 22 less than August 1999. Sydney and Townsville had slow starts to their rotavirus seasons. The total number for Australia for the period 1 June to 31 August 2000 (793) was lower than for the same period last year (909). The rotavirus season of most centres appeared to follow the winter/spring peak, with Western Australia and the Northern Territory experiencing earlier rotavirus season peaks (Figure 10). The Northern Territory experienced a rotavirus season that peaked in May 2000; all 48 reports were from Alice Springs. The timing of the Alice Springs 2000 season appears to be representative of a 'normal' rotavirus season (Fran Morey, Alice Springs Hospital; personal communication). Alice Springs experienced two rotavirus seasons in 1999 (April and October). Serotype analysis of isolates from the Alice Springs specimens, showed that most of the children shared the same infecting rotavirus, serotype G1. and Tasmania had not experienced their respective peaks by August 2000. Further surveillance In order to gain a greater insight into the importance of enteric pathogens, the NRRC has undertaken a pilot study on the prevalence of astrovirus in children admitted to hospital with acute gastroenteritis. We have begun to screen specimens that have had no bacterial or viral pathogen identified by normal diagnostic testing. The specimens are screened by northern hybridisation dot blot analysis. Our results to date show the pathogen may be responsible for up to 4 per cent of hospital admissions in Melbourne. We plan to continue the astrovirus surveillance in other Australian centres and we welcome contributions and comments from interested parties.


Container (1) with at least one support section (2) carrying a packaging material, and together with this box with at least one bottom section (4) and a cover section (3), the section being oriented support (2) in the box so that is deployable from a rest position between base section (4) and lid section (3) in a use position, being the bottom section (4) and section cover (3) component of a box which has four side walls (5, 5 ', 6, 6' '), which bind approximately rectangular to the bottom section (4), wherein a side wall forms an articulation strip (7), which is connected to the side walls of adjacent box through a hinge slot (14) respectively, so that the support (2) in the use position section is steerable plane of the bottom section (4), and that the side walls of adjacent box are stabilized to l least in the rest position, being configured as approximately prismatic hollow side walls (6, 6 ') with an outer wall (32, 32' ') and an inner wall (31, 31' ') respectively, which are orientable as a parallelogram from the plane of the bottom section (4), and joining each hinge slot (14) to an outer wall (32, 32 '') of a hollow side wall (16, 16 ''), and being articulable the support (2) in the articulation strip (7) section.


Market economy requires urgently each citizen of the whole society must possess higher economic quality,it is very important to the sustained economic development of a country.An important approach of improving social economy quality is economy education.Meanwhile,the enhancement of emerging employed people's economic quality is the power and source of promoting the progress of the whole society,and it is significant to the social development.


Nanoindentation measurements with a commercial Hysitron xSol 800 up to temperatures of 700 °C have been applied to study mechanical properties of PM2000 ODS steel. Beside the temperature dependence of hardness H and indentation modulus E, a careful analysis of time‐dependent features such as creep and stress exponent was performed. The H/E is dominated by a transition from small hardness variations at low temperatures to a strong hardness decrease starting at about 400 °C. The two different deformation regimes have been attributed to modifications in dislocation pinning at temperatures up to 400 °C and thermal activation over obstacles, when fine oxide nanoparticles of diameter 5–20 nm are present.


Abstract Background Klebsiella pneumoniae, a leading pathogen for mortality associated with antimicrobial resistance (AMR), was responsible for > 250,000 deaths in 2019. Genomic surveillance can guide the development of vaccines and new antibiotics against this pathogen. While AMR disproportionally affects low-and middle-income countries, limited genomic data are available from these countries. To close this gap, this study provides genomic characterization of K. pneumoniae blood isolates recovered in Peru. Methods Consecutive non-duplicate K. pneumoniae blood culture isolates were collected during an AMR surveillance study (VIRAPERU) from Jul 2017 to Oct 2019, from 15 tertiary hospitals from 13 regions of Peru. DNA extraction (GeneJET, Thermo Fisher Scientific), DNA library (Nextera XT, Illumina) and genome sequencing (MiSeq 500bp-V2, Illumina) were conducted. De novo assembling (SPAdes v3.13.1), quality assessment and annotation (Nullarbor v2.0), and identification of species, ST group, K/O loci, AMR (Kleborate v2.0.1) were conducted. Phylogenetic trees were built with Microreact v.192. Results From 119 K. pneumoniae isolates, 114 were recovered and confirmed to belong to the Klebsiella taxon. Six species were identified, the most prevalent being K. pneumoniae (106), followed by K. quasipneumoniae (3). Among carbapenem-resistant isolates (n=13), 10 (77%) carried the blaNDM-1 gene, while other three carried blaKPC-2 (1), blaIMP-16 (1) or no carbapenemase (1). Phenotypic co-resistance to colistin was present in 2 isolates, both negative for mcr-1 gene. The most common mechanisms of resistance to 3rd generation cephalosporins, quinolones and to aminoglycosides were CTX-M-15 (74.4%), qnrB (63.6%), aac(6')-Ib-cr (87.5%), respectively. Many other AMR genetic determinants were identified (Fig. 1). Sixty ST groups were identified, but only 6 ST groups carried a carbapenemase gene (Fig. 2). A wide diversity of K and O locus was also identified (54 distinct K-loci and 14 distinct O-loci). Figure 1. Genetic determinants of antimicrobial resistance and virulence found in Klebsiella pneumoniae blood isolates of PeruFigure 2. Distribution of ST groups according to specific antimicrobial resistance profiles Conclusion Bloodstream infections in Peru are caused by a wide diversity of K. pneumoniae strains, carrying multiple AMR genes. Carbapenem resistance is principally a result of blaNDM-1 carriage, found across 6 specific ST groups. Disclosures Omai Garner, PhD, Beckman Coulter, Inc.: Clinical trial data collection funded by Beckman Coulter, Inc. Victor Nizet, MD, Cellics Therapeutics: Advisor/Consultant|Clarametyx Biosciences: Advisor/Consultant|Vaxcyte, Inc.: Advisor/Consultant|Vaxcyte, Inc.: Grant/Research Support.


ABSTRACT This article documents and analyses a creative collaboration between the composer Jeremy Thurlow and the violinist Peter Sheppard Skærved in the production of Ouija, a work for solo violin and laptop computer. The article situates the account of this creative process within recent literature on distributed and collaborative creativity, and focuses on three aspects of the project: verbal interaction between the two musicians, analysed in terms of 'creative-talk' and 'face-talk', and the relationship between immediate and more contextual concerns ('inside/outside the room'); a quantitative analysis of changes in the musical material, focusing on timing; and a qualitative analysis of the role of the violinist's embodied and instrumental engagement with the music. The article discusses the findings in relation to forwards-orientated (process) and backwards-orientated (product) conceptions of creativity, the operation of different social components in creative collaboration and the relationship between craft, history and embodiment.


This study was designed to compare a new, autostereoscopic, 'glasses-free' three-dimensional screen with a passive glasses three-dimensional screen, and a two-dimensional imaging system. An objective analysis consisting of two experiments was conducted. The first experiment was designed to assess depth perception. Both 3-D imaging systems were compared to each other and a 2-D imaging system. A statistically significant difference existed between the 2-D screen and both of the 3-D screens (p less than 0.001). There was no statistical difference found between the 'glasses-free' 3-D screen and the passive glasses 3-D screen in either experiment. The second experiment was task oriented designed to compare the new, 'glasses-free' 3-D imaging screen with the passive glasses 3-D screen. In this inanimate setting, the task of passing a needle and suture through a series of hoops was performed faster with the passive glasses 3-D screen but this difference was not statistically significant. Conclusion: The 3-D screens clearly produce more accurate assessment of the depth than the 2-D screen. The new, 'glasses-free' 3-D screen produced comparable results to the established passive glasses 3-D screen.


ceptable levels. In some cases, diets containing 30% fat allowed for more rapid growth than did rations with lower fat levels. Furthermore, the addition of 15% stabilized animal grease, a highly saturated fat, to a ration already containing 3.8% fat resulted in a slightly greater E. DAVID PEEBLES2, J. D. BRAKE, and M. A. LATOUR Poultry Science Depament, P.O. Box 5188, Mississippi State University, Mississippi State, MS 39762 Phone: (601) 325-3379 FAX: (601) 325-8292


This research studies the community of women in Senegal whose husbands migrate to other countries for work. I examine how migration has impacted their marriages and their understanding of their roles as wives. I aim to answer the following question: How does migration affect women's relationships with their husbands, their roles and responsibilities as wives, and their standing in society? To answer this question, I interviewed six women whose husbands work abroad. Before interviewing these women, I will arrange an initial conversation so we can get to know one another. This pre-interview also will allow me to determine other potential participants, as I am to use a snowball sampling method. The official interview may be one-on-one, but I am also open to group interviews should women know other women they would like to join. This research aims to understand how Senegalese women interpret their relationships with their husbands, as well as how larger Senegalese understandings of marriage have adapted to the realities of globalization. As part of this project, I aim to explore how notions of global security extend beyond traditional definitions into the spheres of family life and the home, particularly for transnational families.