Taking Iron Stove village as the object of study and based on deep exploring and surveying about villagers in mountain areas,this paper made a conclusion about the characteristics of mountain building space form in the south Shanxi province,by analyzing its mountain settlements space form and architectural form.That is Mountainous villages have obvious space characters and clear images because of the special terrain where they are located.location distribution,prospect,construction or whatever of the landscape are all presenting vivid space projection and exterior view.In addition connected with local style of "four mains and eight smalls"(four main rooms and eight smaller rooms on both sides in a courtyard) and two-storey lifted beams building form and utilized two lanes paralleling to the contour lines and five passageways vertical to the contour lines make different elements combined orderly.Highly adaptive form of aboriginal residential construction fully reflects that the residents living in the south of Shanxi and the nature coexist in harmony and the comprehension of the traditional Chinese concept of residential areas.


China has a consistent position of "shelve disputes,common development" on Diaoyu islands dispute between China and Japan,and insists peaceful resolution.But Japan does not only accept it,but also expands its control to Chinese inherent sovereign territory,despising international judicial order.The comparative study between Diaoyu islands and Dokdo islands exposes the contradiction of Japan in the territorial dispute,as well as the defects of claim in the territorial arguments.It is the preferred way to solve the Diaoyu islands dispute through the international court by jointing with South Korea and other interestrelated countries.


Many studies have been done on how babies see and what they choose to look at. In the name of science, researchers have subjected some very tiny babies to some quite peculiar tests! As you would expect, a baby's first interest is their mother's face, especially her eyes and mouth, indeed, they can imitate their mother's mouth from a few days after birth. In one test (to prove that they can perceive difference) young babies were presented with a certain pattern until they ignored it, then the pattern was changed or turned upside down and the babies showed renewed interest.


This paper is devoted to present the most recent results regarding the ongoing work carried out in the scope of the STC 4.0 HP project, which aims to automate the finishing process of ceramic tableware at the GRESTEL S.A. industry, focusing on non-circular shaped plates. A collaborative robot is in charge of handling the tableware and making it go around its entire perimeter through a sponge, to perform the finishing. An array, with the distances from the center to the different points of the plate, is applied as data to trace the path that the robot must follow. The final goal of this prototype is to obtain an even finish while maintaining a constant force along the entire perimeter of the ceramic tableware. After carrying out a series of tests, it was possible to conclude that the current approach was able to manipulate 3D-printed tableware made for testing and travel its perimeter to carry out the finishing.


A numerical modelling approach is used to validate the physical and geological reliability of the ablative subduction mechanism during Alpine convergence in order to interpret the tectonic and metamorphic evolution of an inner portion of the Alpine belt: the Austroalpine Domain. The model predictions and the natural data for the Austroalpine of the Western Alps agree very well in terms of P–T peak conditions, relative chronology of peak and exhumation events, P–T–t paths, thermal gradients and the tectonic evolution of the continental rocks. These findings suggest that a pre‐collisional evolution of this domain, with the burial of the continental rocks (induced by ablative subduction of the overriding Adria plate) and their exhumation (driven by an upwelling flow generated in a hydrated mantle wedge) could be a valid mechanism that reproduces the actual tectono‐metamorphic configuration of this part of the Alps. There is less agreement between the model predictions and the natural data for the Austroalpine of the Central‐Eastern Alps. Based on the natural data available in the literature, a critical discussion of the other proposed mechanisms is presented, and additional geological factors that should be considered within the numerical model are suggested to improve the fitting to the numerical results; these factors include variations in the continental and/or oceanic thickness, variation of the subduction rate and/or slab dip, the initial thermal state of the passive margin, the occurrence of continental collision and an oblique convergence.


Taxonomy is viewed as a means of assisting in the development of a unified theory of management and achievement of the status of a true science. A preliminary framework is suggested in the form of ...


Most of radiation protection clothing is made of lead with excellent radiation shielding because it has excellent process ability and economic efficiency and has a high atomic number. However, lead is classified as a hazardous heavy metal, and there is a risk of lead poisoning. Recently, research to replace lead has been actively conducted. In this study, a research on a shielding sheet with improved physical properties while maintaining the radiation shielding ability equivalent to that of conventional materials by mixing two materials that are harmless to the human body, such as BaSO4 and Bi2O3, and a silicone material binder Was performed. For comparison evaluation with the existing lead shielding sheet, the shielding rate was evaluated using a 40 degree shielding sheet having the highest porosity. As a result, it was analyzed that the shielding rate was superior to 9 % or more at the same thickness. In addition, as a result of studies to improve the physical properties of the shielding sheet, it was analyzed that the shielding sheet mixed with BaSO4/nylon/Bi2O3 was the best.


You should be well on your way with plans to implement ICD-10, effective October 1, 2013. If you have not begun your preparation for ICD-10, it is imperative that you start planning now. Below is a suggested action plan to begin your move towards compliance with this federally mandated requirement. • Educate office staff on the ICD-10 compliance requirements. • Review your current systems and work processes – electronic or manual. • Investigate the potential changes to existing practice work flow and business processes. • Contact your current practice management system vendor, clearinghouse or billing service to identify submission upgrade expectations. • Compare options and benefits of full system upgrades vs. minimal compliance to take advantage of new automated features. • Determine installation, testing and implementation timeframes. • Evaluate and plan for staff training needs.


Engine is one of the most important components of a road vehicle such as bus. High performance vehicles has their engine supported by bracket. The engine mounting plays an important role in reducing the noise and vibrations, improving the comfort and work environment of a bus. Engine mounting bracket has been designed as a framework to support engine. The first and foremost function of engine mounting bracket is to properly balance the power pack (engine and transmission) on the vehicle chassis for good motion control as well as good isolation. Present work deals with FE analysis of engine mounting bracket. It includes the modeling of engine mount bracket using CAD software. FE analysis of a typical engine mount bracket of a bus will be carried out and natural frequency will be determined.


N-Propyl- and N-benzyldimethacryloylamines irradiated by γ-rays from 60Co in their glassy state at 77 K yield anion radicals of their methacryloyl groups. These anion radicals afford a triplet with a coupling constant of 1.1 mT on measurement of the ESR and are bleached by a high-pressure mercury lamp at 77 K.


Numerical simulation of leaking hydrogen in a partially open space under natural ventilation is performed . Computation with the LVEL turbulence model (a zero-equation model) and the laminar model showed good agreement with experimental data .The transient behavior of hydrogen difusion in the space is discussed. Also, adequate and important boundary conditions, grid division, and the time step are discussed.


NASA provider SpaceX is scheduled to deliver scientific research, crew supplies and hardware on its ninth Commercial Resupply Services mission to the International Space Station Monday, July 18. Coverage of this mission will begin with a prelaunch news briefing at 2 p.m. EDT Saturday, July 16, on NASA Television and the agency's website.


A theory for copper electropolishing in concentrated phosphoric acid is compared to ac-impedance and electrohydrodynamic (EHD)-impedance spectra. A water-acceptor mechanism is hypothesized. Agreement between experiment and theory is good. Curve fits of the EHD-impedance data estimate that the Schmidt number of the system is Sc 3 X 10 6 at room temperature. At temperatures near 90°C, Sc 7 x 10 4 . The plausibility of these high values of Sc is discussed. These estimates of the Schmidt number are obtained without any assumptions about the bulk concentration of the acceptor. With a known viscosity and diffusion coefficient, the Levich analysis of the variation of the limiting current with rotation speed is subsequently used to estimate the bulk concentration of acceptor. The value obtained is in agreement with the known water content in phosphoric acid which indicates that water is the acceptor species


In microvascular reconstruction of ablative oncologic defects, coupler devices have traditionally been used for venous anastomosis, whereas the arterial anastomosis is hand‐sewn. In the setting of repeated intraoperative arterial anastomotic thrombosis, a coupler device may be of use in reducing the risk of rethrombosis.


This paper examines the effect of global liquidity and financialization on commodity price inflation. The novelty of the paper lies in exploiting recent advances in our understanding of global liquidity by separating private liquidity from official liquidity and digging into disaggregated level non-commercial commodity traders data. Private liquidity is found to be inflationary, while official liquidity is not. Among the non-commercial traders, both, active money managers and passive swap dealers seem to have played an important role in commodity inflation dynamics during the period 2006–2012. The paper also discusses emerging policy issues in a rapidly changing global commodities market.


Novel wide-bandgap polymers based on two different electron-deficient units are designed and synthesized for nonfullerene solar cells with a best PCE of 12.56%.


In this essay, I draw on ethnographic research with South Asian Muslim American gay men of Pakistani descent in Houston to explore everyday negotiations of religion, race, sexuality and transnationalism. The essay highlights three intersecting registers that situate gay Muslim American sexual cultural formations in local, transnational and cultural contexts. Drawing on participant observation and oral life history interviews, this essay examines: (a) culturally constructed male sexualities that are informed by the scripts, language, and cultural idioms of homo-sociality and same-sex eroticism, love and relationships in the homeland; (b) the increasing centrality of belonging to a transnational Muslim ummah; and (c) the appropriation of western terminologies and categories of sexuality in constructing a gay identity. The narratives examined in this essay contribute to cultural analyses of transnational sexual cultures, and ethnographies of Muslim Americans and LGBTQIA immigrant communities in the West.


This article aims to describe some features of the everyday processes that organize work at the open street market. It assumes that symbolic interactions are the substance of these processes. The empirical study was conducted by means of the ethnographic approach in an open street market at Sao Paulo (Brasil). As a labor market, the open street market provides jobs and incomes for about forty thousand workers. The open street market is organized as a social network, and its main features are: to mix labor relationships with friendship, neighbour and family relationship; to be informed by tacit rules and to be sustained by cooperation and competitiveness. The processes that organize the open street market must be understood in face of the process of urbanization in underdeveloped countries.


Understanding microscopic parameters that control steepness of the temperature variations of segmental relaxation (fragility) and the glass transition phenomenon remains a challenge. We present dielectric and mechanical relaxation studies of segmental dynamics in various polymers with different side groups and backbone structures. The results have been analyzed in terms of flexibility of backbone and side groups of polymeric molecules, as suggested by the recent theoretical works by Dudowicz et al. A comparison of structures with identical backbones and varying side groups and identical side groups but different backbones reveals that the flexibility of side groups relative to the flexibility of the backbone is the most important factor controlling fragility in polymers, while the glass transition temperature Tg depends primarily on the backbone flexibility and the side group bulkiness (occupied volume). Based on these results and analysis of literature data we formulated a modified approach to understand...


The article is the first attempt to summarize the issue of color in the Renaissance architecture of Silesia. The introduction outlines the purpose of the article; the architectural context of princely residences, noble and patrician houses, and public utility buildings; and also, the timescale of the Renaissance in Silesia. The basis for examining color schemes was the conducted architectural research, in which, in many cases, the authors participated personally. They included the analysis of technology, building materials, and architectural details, as well as stratigraphic studies of plasterwork and paint layers. As a result of the carried-out analysis, two basic colorschemes were specified. One involves contrasting smoothly painted plaster with brightly painted architectural details, and the other consists in covering the entire surface of walls with a network of thin stripes that imitate squares. Both color schemes were present in two different versions - with the use of either two or three colors, with the most common being: white, red, ocher, black and gray.


ABSTRACT Introduction Scleritis is a severe, vision-threatening ocular inflammation often associated with systemic diseases that carry high risks of morbidity. Timely diagnosis and management are crucial to prevent sequela. Areas Covered This review encompasses the etiology, pathophysiology, classification, diagnosis, and treatment of scleritis with an emphasis on novel diagnostic and treatment modalities. A review of the literature was performed using the keywords 'scleritis,' 'autoimmune diseases,' 'non-steroidal anti-inflammatory drugs,' 'antimetabolite,' 'immunomodulatory therapy,' 'tumor necrosis factor alpha inhibitors,' biologic response modifier' and 'optical coherence tomography.' Expert Opinion Scleritis is mainly a clinical diagnosis. Nevertheless, multimodal imaging may be used in diagnostically challenging cases. New approaches such as anterior segment optical coherence tomography (OCT), OCT angiography (OCTA), and ultrasound biomicroscopy (UBM) may serve as more objective measures to diagnose and monitor scleritis patients. The etiology, severity, anatomical location, and associated systemic inflammatory diseases should be considered when determining scleritis treatment. Currently, first-line treatment in low grade non-necrotizing anterior scleritis is usually non-steroidal anti-inflammatory drugs (NSAIDs) and/or topical/systemic corticosteroids. In non-responsive cases, systemic immunomodulatory therapy (IMT) is recommended. Novel treatment with biologic response modifiers (BRMs) is promising in refractory scleritis. Further studies are needed to evaluate efficiency and safety of BRMs.


A horizontal axis measuring scale of a rotary kiln relates to an axis static measuring tool of the rotary kiln for production in the metallurgical and chemical process, such as aluminium oxide, building materials, nonferrous and metallurgy industries, and is characterized by structurally comprising a vertical ruler, a horizontal scale and a level ruler, wherein the vertical ruler is a straight rod-shaped ruler, and a balancing point with one upper end being fixed on a vertical graduated scale is arranged on the vertical ruler; the horizontal scale with the vertical ruler axis position being 0 degree is marked on the vertical graduated scale below the balancing point; and one end of the level ruler is provided with a ferrule with an inner ring being matched with the shape of the vertical ruler, and the level ruler is vertically and slidably sleeved and jointed with the vertical ruler. The horizontal axis measuring scale of the rotary kiln replaces the traditional combination of a plumb bob and the ruler, when the vertical ruler is higher than the outermost point of the horizontal direction of a rolling ring, is closely attached to the external diameter of the rolling ring and is vertical, the level ruler replaces the ruler, the measurement is simple and convenient, the error is small, the measurement accuracy is effectively improved, and time and labor are saved.


With the depletion and increasing demand of river sand, machine-made sand could be used more and more in concrete. In order to improve the properties of machine-made sand concrete, the effects of the aggregate micro fines (AMF) content, aluminum sulfate, and polypropylene fibers (PPF) on the slump, compressive strength, water permeability, and the chloride permeability coefficients were investigated through a single factor test method, and related mechanisms were analyzed. The results show that the optimum contents of AMF, aluminum sulfate, and the polypropylene fiber are 10 wt%, 1 wt%, and 0.6 kg/m3, respectively. The optimum content of AMF improved the compactness of concrete. The addition of aluminum sulfate promoted the initial formation of ettringite, and thereby improved the compressive strength and the permeability resistance. The polypropylene fiber can modify the pore structure distribution of concrete and reduce the porosity, thereby improving the impermeability of the concrete. The compressive strength of the machine-made sand concrete could be increased by more than 20%, and the water/chloride permeability coefficients could be decreased by more than 45%.


Segmentation is an important step in processing and analyzing time series. In this article, we present an approach to speed up some standard time series segmentation techniques. Often, time series segmentation is based on piecewise polynomial approximations of the time series (including piecewise constant or linear approximations as special cases). Basically, a least-squares fit with a polynomial has a computational complexity that depends on the number of observations, i.e., the length of the time series. To improve the computational complexity of segmentation techniques we exploit the fact that approximations have to be repeated in sliding (moving) or growing time windows. Therefore, we suggest to use update techniques for the approximations that determine the approximating polynomial in a sliding or growing time window from an already existing one with a computational complexity that is independent of the number of observations, i.e., the length of the window. For that purpose bases of orthogonal polynomials must be used instead of standard bases such as monomials. We take two standard techniques for segmentation - the on-line algorithm SWAB (Sliding Window And Bottom-up) and the off-line technique OptSeg (Optimal Segmentation) - and show that the run-times can be reduced substantially for a given polynomial degree. If run-time constraints are given, e.g., in real-time applications, it would also be possible to adapt the degree of the approximating polynomials. Higher polynomial degrees typically result in lower modeling errors or longer segments. The various properties of the new realizations of segmentation techniques are outlined by means of some benchmark time series. The experimental results show that, depending on the chosen parameterization, OptSeg can be accelerated by some orders of magnitude, SWAB by a factor of up to about ten.


Export success among developing countries has been concentrated only in a few countries due to the fact that the comparative advantage of most of the developing countries still lies traditionally in primary commodities and unskilled-labour-intensive manufactures. For export success, these countries have to upgrade their primary and labour-intensive exports into higher value-added items, and move into new, more advanced, export-oriented activities. Both require greater inputs of skill and technology which could be achieved in several ways: by improving and deepening the capabilities of domestic enterprises or by attracting Foreign Direct Investment (FDI) into export activities and upgrading these activities over time. Recently, a much optimistic view on the role of FDI on export performance in the host country has evolved, which was also acknowledged by the Government of India in 1991 through a liberal FDI policy framework which in turn led to a phenomenal rise in the FDI inflows into India. Viewing this increasing trend of FDI inflows into India, this study explores the impact of FDI inflows on the manufactured exports in India. This study finds that the impact of FDI inflows on manufactured exports is significantly positive. The study also suggests that the policy regarding domestic efforts to enhance manufacturing exports needs reassessment in line with the FDI policy framework in order to reap maximum and long-term benefits.


Background Intussusception is the most common cause of intestinal obstruction in infants and young children. Objective To review the clinical, epidemiological, management pattern and outcome of intussusception. Methods A retrospective descriptive review of 47 patients who were diagnosed and managed for intussusception during the period from January 2012 to October 2014 in Al-Ramadi Teaching Hospital for Maternity and Children. Data were collected from the Pediatric Surgery Unit records, which include demographic characteristics of the patients, history of preceding gastroenteritis or respiratory infection, clinical signs and symptoms, imaging studies, type of management, operative finding, outcome and mortality. Data were analyzed by Epi Info7TM, using chi-square to obtain p value which regarded significant when it was < 0.05. Results Records of 47 patients were reviewed; (68.4%) were under one year of age. Peak incidence between 6-12 months of age (55.3%). Male: female ratio was 2.35:1. 27 patients (57.4%) were from rural area, peak seasonal incidence occurred in summer and winter, 41 patients (87.2%) presented with abdominal pain, a palpable abdominal mass was detected in 24 patients (51%), red currant jelly stool reported in (74.5%). Ultrasonography were done for 39 patients and showed an abdominal mass suggestive intussusception (as a target sign or pseudo kidney mass) in 34 patients (87.1%). (95.7%) of patients treated by surgical reduction, while only two patient reduced by hydrostatic enema, Meckle's diverticulum were the commonest pathological lead point (44.4%). No intussusceptionassociated death was recorded. Conclusion Colicky abdominal pain was the most presenting symptoms and red currant stool was a significant sign especially in children ≤ 12 months. Majority of cases presented after 24 hours were from rural area, seasonal peaks occurred in summer and winter months and surgery remain the mode of


Objective: To search the optimal treatment for infantile lactose intolerance.Methods: 360 infants who were diagnosed as infantile lactose intolerance were divided into outpatient treatment group(hereinafter referred to the outpatient group,n=309) and inpatient treatment group(referred to as the inpatient group,n=51).Children in outpatient group were given a short term lactose-free formula feeding,stop breast milk in first 1-2 days and use lactose-free formula feeding,from the 2nd day,gradually increase the feeding frequency and quantity depending on the defecation situation.The transition time lasts for 7 days,and then the breast milk feeding is restored.This method was removal of lactose in milk,no drugs.Children in inpatient group were given a routine examination,cephalosporins(50-100) mg·kg-1 for inflammation,montmorillonite powder for diarrheal and Bifidobacterium tablets for intestinal flora disturbance,Supplement of water and electrolyte and nutrition support were given.Results: The average turnaround time for symptoms of diarrhea was(2.74±1.575) d in outpatient group,(14.30±11.597) d in inpatient group.There was a significant difference(t′=0.00749,P0.01) between the two groups.Respiratory infection was 38 cases(12.298%) in outpatient group and 16 cases(31.373%) in inpatient group.There was a significant difference(u=3.534,P0.01) between the two groups.The average weight gain in 1 month after the onset was(0.93±0.512) kg in outpatient group and(0.70±0.543) kg in inpatient group.There was a significant difference(t=0.031695,P0.05) between the two groups.Conclusion: For those infants who are diagnosed as lactose intolerance with diarrhea,we may choose the outpatient treatment.We should instruct their parents for a short-term lactose-free formula feeding in order to avoid hospital cross-infection and antibiotic abuse.This is conducive to the recovery and growth of infants,and the decrease of the occurrence of complication.


REB 36 1978 France p. 171-191 ; T. Miller, The Basilika and the Demosia. — In the fourth book of his History the emperor John VI Cantacuzenus states that the Galata War of 1349 had been financed from two state treasuries, the basilika and the demosia. In other passages the emperor refers to these same two treasuries. His language suggests two central financial offices in the structure of the late Byzantine bureaucracy, but many students of Byzantine history have detected only one, what they call the bestiarion. This article examines some of the documents of the Palaeologan period to prove that there were surely two separate financial offices and that this distinction was rooted in bureaucratic tradition and in the method of land classification. The study concludes with some observations on the significance of the financial offices in the decline of the Byzantine state and on their role in encouraging opposition to the aristocratic movement of John Cantacuzenus.


Bortezomib‐induced peripheral neuropathy (BIPN) is a common toxicity associated with the treatment of multiple myeloma (MM), typically requiring dose reduction, delay, or cessation of treatment protocol.


mHE QUESTION of the relationship between urbanization and national 1 development has been the subject of numerous papers by scholars from a wide range of disciplines, especially in the social sciences. A major stimulant for this interest is the realization that there has never been a significant economic development in any country without an urban structure. Moreover, studies in market economies with low and middle level per capita income show that there has been an almost universal positive relationship between the growth of urbanization, industrialization and GNP. The causal relationship or its direction are still controversial. An inductive theory, which has been around for some time, although not originally intended as an explanation for urbanization as such, is "structural change. " It maintains that in the course of economic development the structure of production first shifts from primary products (mostly agriculture, mining and unskilled services) to secondary products (mostly manufacturing) and then to tertiary products (mostly skilled services). This change is attributed primarily to the income elasticity ofdemandwhich is high for secondary and, at still higher incomes, high for tertiary products. Some writers, notably Kuznets, pointed to some factors on the supply side as well. When the analysis is confined to the demand explanation the implication is that urbanization is primarily a result of economic progress. But when the supply side is included, then, if it could be shown that urbanization contributes to productivity growth, urbanization becomes a cause of economic development. The few urban economists who-refer to the possible impact of urbanization on the aggregate economy associate it with characteristics of the spatial and size distribution of cities. The implication is that if there is spillover of agglomeration economies from the metropolitan to the surrounding areas it is confined to a certain range. Therefore, smaller cities should be within that range to benefit from it. On the other hand, metropolitan areas with similar characteristics should not be too close to each other. A number of studies have shown that per capita income is closely associated with city size. However, there is still uncertainty whether city size (let alone urbanization) can be a truly independent variable. An early article


The article discusses the function that should be exerted by colleges and universities in cultivating students'gratitude mentality and the proper approaches be adopted,by analyzing the moral and psychology behavior of students shown by their loss of the gratitude mentality.


Supporting quality of service (QoS) in wireless networks is a challenging problem. The point coordination function (PCK) in IEEE 802.11 LAN standard was developed to support the transmission of real-time data. However, PCF was not able to meet the requirements of real-time data. Therefore, several IEEE 802.11e drafts, whose main task is to support QoS, were released after IEEE 802.11. The polling scheme of PCF is extended in IEEE 802.11e into the more complex hybrid coordination function (HCK). We found that HCK has several performance issues that may affect its anticipated performance. In this paper, we address these issues and propose a QoS enhancement over PCK, called enhanced PCF (EPCF) that enables wireless LAN to send a combination of voice, data and isochronous data packets using the current IEEE 802.11 PCF. We compared the performance of the proposed model (EPCF) with the HCF function of the IEEE 802.11e through simulation and we extend the proposed model (EPCF) to work in a multi-hop wireless ad hoc mode. The simulation results demonstrated an enhanced performance of our scheme over the legacy PCK and a comparable performance to the IEEE 802.11e HCF in terms of average delay and system throughput. However, EPCF is much simpler than HCK, provides service differentiation on flow level, and can be incorporated easily into the current IEEE 802.11 standard.


The Just-Pope production function represents an important methodological innovation in the agricultural economics discipline. It retains the convenience associated with production function representations of technology while allowing inputs to affect the mean and variance of production independently. The function and its variants have found several applications, including analyses of the effects of fertilizer on risk in rice production (Rosegrant and Roumasset) and those of fertilizer and water on field crops in Arizona (Lambert). Just and Pope, in their original article, outlined a multistep consistent estimation procedure, and utilized experimental data for an empirical illustration. While experimental data serve several purposes in agricultural economics, many important questions require the use of observed economic data.1 The question, then, is, Are estimates of Just-Pope production functions, separate from the first-order conditions for input choice, consistent? This question arises because the separate estimation of production functions has long been a controversial issue. Since the landmark


The article presents the principles of a comprehensive system approach to the analysis activities of the University. Presents a variant analysis work of the University in the three ways: sphere of the University activities; basic scientific direction of the specialists training; methods of data processing and calculation indicators of the University activities. Presents the criteria that must be correspond the system indicators of the efficiency and effectiveness of the University. Applying of the developed system of indicators will allow to optimize process of the management decision of the University.


This paper reports on novel and efficient enhancement effects of fruit juice aroma using immobilized β-glucosidase, the enzyme involved in important functions in living organisms, onto superparamagnetic nanoparticles Fe3O4 via carbodiimide β-glucosidase was purified from mandarin (Citrus reticulata) using ammonium sulfate precipitation and hydrophobic interaction chromatography. To be used in this study, superparamagnetic nanoparticles were synthesized and then the shape, size, and magnetism properties of the nanoparticles were characterized. The purified enzyme was immobilized on the nanoparticles. The optimum temperature for β-glucosidase (40 ℃) was increased by 10 ℃ after immobilization, while the optimum pH values of free and immobilized β-glucosidase were 5.5. While the Km and Vmax values of the free enzyme were 0.264 mM and 294 EU, immobilized enzyme's Km and Vmax were 0.222 mM and 370 EU, respectively. In addition, it was determined that the storage stability of the immobilized enzyme was higher than the free enzyme. When the effect of some metal ions on the enzyme activity was examined, it was observed that Fe+2 increased the enzyme activity while other metals inhibited it. According to the results obtained, the immobilized enzyme had a flavor-enhancing effect on mandarin juice.


The present invention discloses a composite article and methods of making the composite article. The composite article comprising (a) a metal-containing material and polymeric binder material, or (b) polymeric binder material and a carbonaceous material. The method comprises heating and mixing the components of the composite article, and then the mixture is heated to form the shape of the final product, a heating step sufficient to melt at least a portion of the polymer binder material to facilitate the formation of the article.


In this paper, a mathematical model of cancer treatment, in the form of a system of ordinary differential equations, by chemotherapy and radiotherapy where there is metastasis from a primary to a secondary site has been proposed and analyzed. The interaction between immune cells and cancer cells has been examined, and the chemotherapy agent has been considered as a predator on both normal and cancer cells. The metastasis may be time delayed. For better investigation of the treatment process and based on physical investigation, the immanent effects of inputs on cancer dynamic have been investigated. It is supposed that the interaction between NK cells and tumor cells changes during the chemotherapy. This novel approach is useful not only to gain a broad understanding of the specific system dynamics but also to guide the development of combination therapies. The analysis is carried out both analytically (where possible) and numerically. By considering such immanent effects, the tumor‐free equilibrium point will be stable at the end of treatment, and the tumor can not recur again, and the patient will totally recover. So, the present analysis suggests that a proper treatment method should change the dynamics of the cancer instead of only reducing the population of cancer cells. Copyright © 2016 John Wiley & Sons, Ltd.


The mixture of beef tallow with rapeseed oil (1:3, w/w) was interesterified using sodium metoxide or immobilized lipases from Rhizomucor miehei (Lipozyme IM) and from Candida antarctica (Novozym 435) as the catalysts. The chemical interesterifications were carried out at 60 and 90°C for 0.5 and 1.5 h using 0.4, 0.6 and 1.0% of CH3ONa. Depend on the catalyst used the enzymatic interesterifications were carried out at 60°C for 8 h (Lipozyme IM) or at 80°C for 4 h (Novozym 435). The catalyst doses were kept constant (8%) but the water content in catalysts was changed in the range of 2 to 10%. The starting mixture and the products of interesterifications were quantitatively separated into pure triacylglycerols and non-triacylglycerols fraction containing free fatty acids and mono- and diacylglycerols. It has been found that after interesterification the concentrations of free fatty acids and partial acylglycerols increased. On the other hand the slip melting temperatures and solid fat contents in triacylglycerols isolated from interesterified fats and their oxidative stability were lower if compared with noninteresterified, initial blend. It was interpreted on the base of alteration on molecular structure of triacylglycerols as confirmed by their sn-2 and sn-1,3 distribution of fatty acids before and after interesterification. These distributions were practically random after chemical interesterification and close to random when Novozym 435 was applied. When Lipozyme IM was used the fatty acids composition at sn-2 position remained practically unchanged if compared with starting blend.


Abstract This paper reports the findings of a research project, conducted within the Division of Education at the University of Sheffield, which used computer‐mediated communication (CMC) to support postgraduate students in distance‐education contexts. Following Moore's theory of transactional distance, the project aimed to identify and explore the ways in which CMC may reduce transactional distance by mediating the academic and social dialogue between distance‐education students and their tutors. In particular, we were interested in (a) the extent to which a 'community' of learners could be constructed within an on‐line environment and (b) the socio‐academic nature of such a community. Our research findings indicate that CMC can support the construction of an on‐line learning community capable of providing significant social and academic support to students. We suggest, however, that the construction of an effective on‐line learning community may depend upon the provision of adequate opportunities for so...


Abstract We theoretically and numerically investigate the instabilities driven by diffusiophoretic flow, caused by a solutal concentration gradient along a reacting surface. The important control parameters are the Péclet number $Pe$, which quantifies the ratio of the solutal advection rate to the diffusion rate, and the Schmidt number $Sc$, which is the ratio of viscosity and diffusivity. First, we study the diffusiophoretic flow on a catalytic plane in two dimensions. From a linear stability analysis, we obtain that for $Pe$ larger than $8{\rm \pi}$ mass transport by convection overtakes that by diffusion, and a symmetry-breaking mode arises, which is consistent with numerical results. For even larger $Pe$, nonlinear terms become important. For $Pe > 16{\rm \pi}$, multiple concentration plumes are emitted from the catalytic plane, which eventually merge into a single larger one. When $Pe$ is even larger ($Pe \gtrsim 603$ for Schmidt number $Sc=1$), there are continuous emissions and merging events of the concentration plumes. The newly found flow states have different flow structures for different $Sc$: for $Sc\geqslant 1$, we observe the chaotic emission of plumes, but the fluctuations of concentration are only present in the region near the catalytic plane. In contrast, for $Sc<1$, chaotic flow motion occurs also in the bulk. In the second part of the paper, we conduct three-dimensional simulations for spherical catalytic particles, and beyond a critical Péclet number again find continuous plume emission and plume merging, now leading to a chaotic motion of the phoretic particle. Our results thus help us to understand the experimentally observed chaotic motion of catalytic particles in the high $Pe$ regime.


The power system in the Danish island Bornholm is a distribution system with a high penetration of wind generation, which is representative for expected future power systems. During the period from 11th to 14th September 2007, the Distribution System Operator (DSO) Ostkraft in Bornholm conducted a planned islanding operation test. To evaluate the test and achieve useful experience for future similar operations in Bornholm or even in other similar systems, the frequency data before, during and after this period, were recorded by Phasor Measurement Units (PMUs), supplied by Centre for Electric Technology (CET), Technical University of Denmark (DTU). Statistical analysis of frequency data has been performed and the results reveal that the frequency quality during the islanding period was significantly decreased, indicating the need for enhancing frequency control of such systems in the future.


The massive data generated by users in online platforms, such as social networks, create challenges for text classification tasks based on supervised learning. Supervised learning often requires a lot of feature engineering or a significant amount of annotated data to achieve good results. However, the scarcity of annotated data is a critical issue, and manual annotation can be both costly and time-consuming. Semi-supervised learning requires far less annotated data and achieve similar performance as supervised approaches. In this paper, we introduce a semi-supervised neural architecture for muti-label settings, that combines deep learning representation and k-means clustering. The results show that the semi-supervised approach can leverage large-scale unlabeled data and achieve better results compared to baseline unsupervised as well as supervised methods.


This study explores the impact of chief executive officer (CEO) succession on new-firm performance, using a sample of Japanese firms founded during the period 2003–2010. When controlling for firm- and CEO-specific characteristics, we find that new firms with experience in CEO succession are more likely to increase sales than those without it. The results also reveal that CEO succession influences sales growth among new firms, but not employment growth. Moreover, based on successor origin, we classify the types of CEO succession, such as inside, outside, and family succession. The results reveal that both insider and outsider succession influences sales growth, while family succession does not.


The invention discloses a self-supporting PEDOT-PSS film, which comprises PEDOT and PSS at a mass ratio of 3 to 7-15 to 2. The PEDOT-PSS film has a thickness of 1 mum to 50mum, the square resistance is 0.10omega/sq-120omega/sq, and the conductivity is 210S/cm-1827S/cm. The invention also discloses a PEDOT-PSS film manufacturing method and applications in an electrode of an optoelectronic device. The PEDOT-PSS film manufactured by the method of the invention has good self-supporting performance and conductive performance and can be widely applied to the optoelectronic device.


The theme of the conference regards images. Since the theme is so vast, I have handled it by dedicating to it some basic general reflections. Therefore, I maintain that the best choice is to evoke the aphorism in the epigraph: I propose a series of fragmented memories or annotations taken while reading and looking at images, or even citations.


Programs for calculating direct-beam fast neutron and gamma dose rates in and around cylindrical shield regions coaxial with cyllndrical source regions were coded for the IBM 701. Checkout of the fast neutron program using the Albert-Welton point kernel and the present status (up to June, 1955) of the garama program are discussed. Instructions for using the fast neutron program are included. (auth)


The vibration characteristics of cantilevered straight and curved carbon/epoxy bistable reeled composites (BRCs) have been investigated. The tube length, cross-section radius, subtending angle, longitudinal curvature and number of plies - design parameters were investigated for their effects on the vibration modes. The boom length affects the frequency the most, which is found to be inversely proportional to the square of boom length, in addition to ABAQUS simulation results showing that frequency is proportional to curvature. Short, three-ply carbon/epoxy samples were manufactured and tested. A regime change from short (48.5cm) to slender (≈150cm) tubes was observed, signified by curved tubes exhibiting higher vibration modes in a particular plane than the straight ones in simulation - highlighting the scalability of curved BRC applications. Recommendations for the upcoming CleanSpace One, EPFL space mission which uses curved tubes for its capture mechanism, are discussed. Dynamic stability analysis was performed by simulating increasing rotary accelerations, causing the cantilevered BRCs attached to a spacecraft to rotate. A failure point derived from the Budiansky-Hutchinson criterion was developed to determine the maximum rotation acceleration - the critical value by which the tube loses stability.


The operational hazards associated with the use of a plutonium-fueled thermoelectric generator in a terrestrial satellite are evaluated. It appears that the plutonium fuel can be consumed and dispersed at high altitude during reentry, following a successful mission. As an alternative, however, since the fuel (Pu/sup 238/) is an alpha emitter with a long half life, it appears that random intant recntry following a suceessful mission is feasible. As a precaution against aborted missions, the launch azimuth should be over water as much as possible to avoid impact or dispersion in areas of signifieant population density. It is recommended that the fuel and generators be transported by air carrier to preclude local restrictions of ground transport and to provide better statistical safety. The transport phase poses a very minor safety problem. (auth)


The catalytic activities of 9 metal ions in the autoxidation of potassium salt of 1,2-dihydroxynaphthalene-4-sulfonate in aqueous solution were measured. All the metal ions including the first transition metals were found to accelerate the autoxidation. The catalytic activities of the metal ions were correlated with the stability constants of the substrate-metal ion complexes.


Advanced oxidation is one of the most important chemical treatment methods used for complete mineralization of organic pollutants present in the wastewater. The manufacturing plant of N,N'-dichloro bis-(2,4,6-trichlorophenyl)-urea (CC2) produces wastewater containing pyridine, acetic acid and diphenyl urea. The effectiveness of advanced oxidation processes (AOP) for the treatment of wastewater discharged from the CC2 plant was investigated in this study. Four types of advanced oxidation processes (H2O2/Fe 2+ , H2O2/Fe 2+ (Fe 3+ )/UV, H2O2 (without catalyst) and TiO2/hv/O2) were examined. Fenton's reagent and Fenton's type reaction was able to effectively destroy pyridine and other pollutants in the wastewater. It was observed that, by advanced oxidation process, a maximum of 74.0 percent chemical oxygen demand (COD) removal was achieved. The rate of COD removal was in the order of H2O2/Fe 2+ > TiO2/H2O2 > H2O2 (without catalyst) > TiO2.


The electrical properties of a stationary electric contact are closely related to phenomena occurring in the very small contact spots of the interface. Contact spots in aluminium-aluminium interfaces that have passed heavy direct currents have been studied. The size, shape, and appearance of the spot fractures were found to be correlated to the surface roughness and to the recorded voltage and resistance characteristics. Rough contact surfaces caused irregularly shaped contact spots to develop, while high and unstable resistances were always associated with large contact spots. The latter observation indicates that the electrical conductivity of the contact spots has been reduced by the electrical stresses: the spots have aged. Aging of a contact point leads to the formation of new current paths through the interface, in the vicinity of the original ones. The aging rate increases rapidly with increasing voltage drop across the interface.<<ETX>>


We formalize and test arguments originating with Schattschneider and Burnham about elite control of the governing process in the "system of 1896." To do so, we draw upon classic elite theory and contemporary public policy theory to specify the particular ways elite power might have operated and to deduce a series of hypotheses about such power at various stages in the policy process. Our empirical tests of the resultant propositions-for the controversy over direct democracy reform adoptions in individual American states-offer notable evidence for elite influence over the active agenda status of direct democracy proposals, as well as over the adoption, scope of adoption, and speediness of adoption of such reforms.


The invention discloses a generating system of a speech two-dimension code and an operation method thereof. The generating system of the speech two-dimension code structurally comprises a mobile terminal, a system server, a speech input system and a speech two-dimension code generator, wherein the mobile terminal comprises a mobile terminal transmitting end and a mobile terminal receiving end, the mobile terminal transmitting end is connected with the speech input system and the speech two-dimension code generator through the network, the system server is connected with the speech input system and the speech two-dimension code generator through the network, and the speech two-dimension code generator is connected with the mobile terminal receiving end through the network. The generating system of the speech two-dimension code has the advantages that a two-dimension code is directly output to be speech after being scanned, the damage degree of the quality of the speech is reduced, and integrity and stability of speech information are maintained; the problem that the data capacity of the two-dimension code is not large enough is solved; and digitization and informatization of the speech are achieved, a user can record and read speech information at any time, and timely and real-time communication is achieved conveniently.


This letter presents a novel initial rotor position estimation for a salient-pole permanent magnet motor. The proposed method is based on the measurement of the resonance frequency of the current between two phases. The basic method is verified by experimxents.


The investigations of superhydrophobicity and self-cleaning surfaces have been given a lot of attention in the last few decades. The surfaces having water contact angle larger than 90° are termed as hydrophobic surfaces and those which exhibit contact angle higher than 150° are said to be superhydrophobic. Such surfaces were first observed in nature in various plants and animals, for example, lotus leaf-like structures. Water repellence of various materials have shown great influences on various applications such as self-cleaning, anti-ageing, water-oil separation, water corrosion in electrical industry, water proof textiles, controlled transportation of fluids, etc. Generally, surface micro/nanostructuring combined with low surface energy of materials leads to extreme anti-wetting properties. The hundreds of research articles and more than 450 patents on the subject of nature mimicking self-cleaning surfaces prove the potential of this topic. Self-cleaning property depends on both surface morphology and surface chemistry. For achieving superhydrophobic surfaces, we can, typically, either increase the roughness of the intrinsically hydrophobic material or tune desired roughness and morphology on hydrophilic surfaces. Depending on such parameters a water droplet on the surface attains either Wenzel or Cassie-Baxter state. For the preparation of superhydrophobic surfaces, various physical and chemical methods have been successfully used. Methods such as hydrothermal process, using various templates, plasma surface modifications, physical and chemical vapour deposition, layer by layer deposition, electrospinning and sol-gel processing have been used for achieving desired roughness and surface chemistry on various © 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. substrates. In this field of research, various fabrication methods have significant role in deciding the extent of superhydrophobic behaviour of the surface, depending on the material which is used for the processing. In this chapter, the most recent developments in various methods used for fabricating superhydrophobic surfaces are presented along with their advantages and limitations.


Any practical tracking algorithm must mitigate the effect of both nonstationary environments and loud interfering sources. The dominant mode rejection (DMR) adaptive beamformer (ABF) is often used to address these challenges. The DMR beamformer periodically updates the sample covariance matrix (SCM) employed to compute the ABF weights. A tension arises between the large number of snapshots required for each SCM update to null loud interferers effectively and the small number of snapshots required for each SCM update to track nonstationarities. In practice, observed notch depths for DMR fall dramatically short of those predicted theoretically from ensemble statistics. This talk bridges the gap between theoretical and observed performance by presenting a simple linear asymptotic model for the DMR notch depth derived from random matrix theory results on the accuracy of the SCM eigenvectors. The model predicts the mean DMR notch depth as a function of the number of snapshots given the interferer-to-noise rati...


In March 2010, the European Union (EU) modified their aflatoxin limits and sampling plans for almonds, pistachios, and hazelnuts to closely resemble that developed by Codex in 2008. To assist the USA almond industry evaluate how to modify their aflatoxin sampling plan to minimise USA lots rejected by the EU at import, studies were conducted to: (a) develop a model to predict the number of USA almond lots rejected at origin and at destination by various Codex style aflatoxin-sampling plans used by the USA where accept/reject limits vary from EU limits of 8 ng/g aflatoxin B1 / 10 ng/g total aflatoxins (AFT) to 8, 6, 4, 2, and 0.5 ng/g AFT; (b) determine the effect of the level of aflatoxin contamination among lots tested in the USA on the number of lots accepted and rejected at origin and at destination; and (c) develop a method based upon lots rejected in the USA to predict the lots rejected several months later in the EU. For a given USA crop contamination level, as the accept/reject limits of the USA sam...


The purpose of this report is to describe semantic properties of languages that support direct access to items in persistent data spaces. These languages differ in non-trivial ways from more familiar languages which describe processes operating over data represented in a transient memory. These semantics are presented with respect to a formal Turing machine model, which we first develop. Then, we examine issues associated with type and class inheritance which we regard as distinct concepts, with symbolic naming, with set operation semantics which are somewhat surprising, and with data deletion which is quite difficult. Finally, we hint at a few of the differences in programming psychology which are engendered by such semantics. This research was supported in part by DOE Grant #DE-FG05-88ER25063. and by JPL Contract #957721. Our goal is to examine necessary characteristics of programming languages that allow a programmer to directly reference and manipulate persistent data. It would be linguistically convenient if persistent data could be treated in precisely the same manner as a program's nonpersistent data. Various authors have proposed this as a language design goal, e.g. [AtB87]. In this report, however, we will argue precisely the opposite; that programming languages must necessarily distinguish between persistent and non-persistent data; and that familiar data types associated with non-persistent data in an executing program need not be appropriate for persistent data. Our first task will be to characterize just what we mean by persistent data. One frequently encounters definitions of persistence in terms of a persistent recording medium, or in terms of its long life. While we intuitively think of persistent data as residing in files on disk or tape storage, rather than RAM, the introduction of memory resident databases [SaG90, Son89] clearly forces a re-evaluation of such an intuitive definition. Persistent data is often long lived, but it need not be. And long lived data need not fit our sense of persistent data; the local variables of a nonterminating process such as an airline reservation system can have a very long life. The real essence of persistence seems to be that it exists independent of any particular process, that multiple processes can access it1, and that, unlike local variables in a stack model, the data can be changed only by a deliberate rewriting of it. To discuss programming over a persistent data space we will need a semantic model of such computation. For this we use a Turing machine model, and in the next section develop a number hhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhhh 1 While persistent data must be capable of being shared by several processes, this property by itself is not sufficient to characterize persistence. Data may also be shared between processes by a variety of argument passing mechanisms in procedure calls, or by explicit message passing, e.g. [Hoa78]; none of these need imply persistence. of fundamental concepts based on it. Although it is not our purpose, this development can also serve to describe the semantics of object-oriented databases as well. Then, in Section 2, we will develop a distinction between data types and element classes that appears to be fundamental in the development of distributed heterogeneous databases. And, we will exhibit two rather surprising results concerning the semantic behavior of union and intersection operators on sets of data. In Section 3, we will address the issue of expanding the name space of a programming language to accommodate the naming of persistent data, and finally, in Section 4, we examine issues associated with the deletion of persistent data.


The utility model discloses an automatic multi-wire winding machine comprising a wire tensioning mechanism, a rotating winding mechanism, a wire guiding mechanism, a wire cutting mechanism, a stator rotating positioning mechanism, and a control assembly used for controlling various mechanisms. The wire tensioning mechanism mainly comprises a wire tensioning mechanism frame. The rotating winding mechanism is disposed on the rear end of the wire tensioning mechanism, and mainly comprises a rotating winding mechanism support, a rotating winding assembly fixedly disposed on the rotating winding mechanism support, and a chuck mechanism coaxial to the rotating winding assembly. The rotor rotating positioning mechanism is disposed on the rear end of the rotating winding mechanism, and comprises a product pedestal, a rotating rod used for driving the product pedestal to rotate, and a translation assembly used for driving the rotating rod to move forwards and backwards. The wire guiding mechanism is disposed between the rotor rotating mechanism and the rotating winding mechanism, and comprises a wire guiding assembly, and a wire guiding assembly driving mechanism used for driving the wire guiding assembly to move forwards and backwards. The wire cutting mechanism is disposed on the rear end of the rotating winding mechanism, and comprises a telescopic block assembly and a cutter head assembly. The automatic multi-wire winding machine is advantageous in that the automatic control of the whole wire cutting process from the wire feeding process to the wire winding process can be realized, the manual operation is not required, and therefore the working efficiency is high, and the reject ratio of the processed products is low.


A new laser focal spot analyzer system has been developed that permits the real time measurement of a high power fiber laser in excess of tens of kilowatts which can provide the laser's spatial profile, circularity, centroid, astigmatism and M-squared values using all the optics used in the process application, including the focus lens and cover glass. This novel beam analyzer system is both compact, real time and has no moving parts by incorporating an all passive optical design, thereby accommodating the measurement of the focused beam waist: spot diameter, M-squared, Rayleigh length, beam waist position and many other beam parameters to power levels in excess of 20 kW in real time and in less than one second from laser off to laser on.


When the amount of physical activity increases due to sports, it is necessary to consider the appropriate amount of energy and intake of each nutrient commensurate with the amount of activity. In addition, elite athletes with rigorous training need to be aware of their excess or deficiency of certain nutrients to prevent injuries and illnesses. In particular, the chronic lack of energy intake of athletes has been clearly shown to be related to future diseases, which is a major problem. On the other hand, research is progressing on how to devise nutrient intake according to training and game schedules, and supplements for the purpose of improving performance are also being active-ly developed. There are many problems with the use of supplements, such as the relationship with doping control and a lack of education for junior athletes. In the future, nutrition at sports sites will require more personalized support, and it is hoped that a large amount of evidence will be accumulated.


Traditionally, economic analyses were confined to inputs and outputs incurred or produced directly by the project. Now, many indirect costs are included in the economic analyses by means of environmental and/or non-market valuation. This process is called the extended benefit-cost analysis. A case study is presented for a hydropower project from Sri Lanka, for which an attempt was made to quantify and incorporate in monetary terms the cost of some environmental impacts to the economic feasibility, using valuation techniques based on the principles of environmental economics. It develops the financial, economic and extended benefit-cost analyses assuming the hydropower project to be demand driven.


A high directivity TIR (total internal reflection) lens in the UV-A region was designed using a silicone resin, and a UV light source module with a maximum irradiation density of $150mW/cm^2$ was fabricated. The beam angle of the TIR lens was designed to be $8.04^{\circ}$ and the maximum diamete...


In this paper we establish a relationship between the core cover of a compromise admissible game and the core of a particular bankruptcy game: the core cover of a compromise admissible game is, indeed, a translation of the set of coalitionally stable allocations captured by an associated bankruptcy game. Moreover, we analyze the combinatorial complexity of the core cover and, consequently, of the core of a compromise stable game.


The present invention provides a genuine proof of methods for the provider for verification system, an authenticity proof of the transaction initiated by the user, by sending the details of the transaction that was started to the verification system requesting said by sending the details of the transaction to the user mobile device, requesting to perform the authenticity proof of the transaction on the mobile device to the user, which is received from the verification system a request for authenticity certificate verified on the mobile device, the step of prompting to enter a personal identification number to the user, when a valid personal identification number is received, displays the transaction details to the user, required to perform the authenticity proof of the transaction to the user Steps, upon receiving the authenticity verification by the user, when the step for generating the authenticity proof parameters for transmission to the verification system, and valid authentic proof parameter is received from a mobile device user, the provider about authenticity certification method including the step of authenticity proving the transaction against.


Ventricular tachycardia (VT) is usually observed in patients with structural heart disease. However, in 10% of the patients presenting with VT, the routine diagnostic modalities demonstrate no myocardial damage. This arrhythmia has been identified as an idiopathic ventricular tachycardia (IVT), and is commonly observed in young patients. Recent studies delineated the mechanisms and anatomical locations responsible for these VTs. Recognition of the various forms of idiopathic VTs is based on the characteristic QRS morphologies observed in the 12-lead electrocardiogram (ECG). A greater understanding of the sites of origin of the idiopathic VTs has led to the increasing success rate of the catheter ablation of these VTs. On the surface ECG, an IVT from the aortic sinus cusp (ASC) has a QRS morphology similar to that of right ventricular outflow tract (RVOT) arrhythmias. This similarity often obscures the origin of the VT. We reported 1 case of an IVT which originated from the aortic cusp.


[Objective] The research aimed to promote the development of pollen forecast,prevent the incidence of pollen allergic disease,improve the health level of people and decrease the medical expenditure.[Method] Through holding the symposium of medical experts and making questionnaire for patients,the social benefits of pollen forecast were preliminarily evaluated from 4 aspects of forecast accuracy,forecast efficiency,information coverage ratio and the prevention ability of patients.[Result] Pollen forecast was in demand for 88% of respondents and 75% of them were satisfied with pollen forecast.The social benefits were more significant.[Conclusion] The pollen forecast was the demand of social development and it was one of effective measures for preventing the allergic disease of pollen.


Purpose:  To evaluate the efficacy and safety of long‐term application of autologous serum eye drops treating recalcitrant dry eye syndrome.


A model is developed for examining thermal-energy transfer from the arc to the rails in an arc-driven rail gun. Resistive heating within the rails is also accounted for, though the contribution to the rail temperature from this mechanism is frequently negligible. Melting of the rail surface is allowed in the model, but it is assumed that the melted material is swept away and absorbs no further energy. A set of differential equations is presented which, when solved, yield the temperature, magnetic induction, and current density within the rail, as well as the mass lost from the rail surface. The model is then used to analyze rail melting in a recent experiment by Jamison and Burden, using as input data in the model experimentally obtained parameters.


Physical (anthropometric) and biochemical evidence of malnutrition or of " nutritional risk" among children in the Ten-State Nutrition Survey reflected primarily an inadequacy of total energy intake and not improper selection of foods or "unbalanced" diets. Thus, the quantity of food—not the quality—was the major dietary problem highlighted by the Ten-State Nutrition Survey.


Wafer-like porous xLiV3O8-yLi0.3V2O5 (Li–V–O) composites are synthesized by a facile self-assembled synthesis using a glycine-assisted solution route followed by a low-temperature reaction. The cry...


Flow separation will occur in the nacelle inlet under crosswind operation, which will result in engine intake distortion and even engine surge. To study the reference characteristics of the flow field of the short tank inlet separation under the influence of crosswind, this paper observed the cloud map of the total price loss coefficient by changing the flow deflection Angle and flow velocity, made a qualitative analysis of the total pressure distortion degree, then calculated the average total pressure loss coefficient and distortion index, and conducted a quantitative analysis to explore the improvement of the total pressure distortion under different flow field factors. The results show that the degree of total pressure distortion is improved with the increase of incoming flow velocity at a small inlet deflection Angle, but with the increase of incoming flow deflection Angle, the ability of incoming flow velocity to improve the total pressure distortion gradually weakens until it disappears. The inlet deflection Angle plays a decisive role in the improvement effect of incoming flow velocity on the total pressure distortion.


Documentary sources accessible while scattered throughout much of the world either through the Internet or any other data transmission network, you must know, analyze and if necessary use, especially when launch a consultation on any of the specialized search engines or Internet generic as it can to help or complicate the process, whether little or too much information.

Well known although it should be noted that the New Technologies of Information and Communication NTIC facilitate the editing and dissemination of documents circulating on the network, under various types and formats, hence specialized information to identify each of the scientific areas , talk as well as traditional sources, the virtual drive on the network, since the scientific community has incorporated its production in various forms and institutional arrangements in files and / or specialized networks both nationally and internationally. This set of strategies adopted by developers and managers of information, means that users have to navigate the large stage that the network offers.

This is study is a compilation of sources on the History of Education (H. E.) freely available on the Internet, the idea is to produce a guide as comprehensive as possible. For ease of reference, grouped according to their type of document and, in each, is a summary of the information it gathers the most relevant data indicating by one or more links. Referenced together information on 10 specific journals, virtual libraries historical 4, 2 bibliographic databases, 2 specific institutions, 17 museums and two planned teaching and 9 specialized websites.


In order to increase revenues and sustain business, the music industry is directing efforts into increasing paid subscription by converting free listeners into paid subscribers. However, most companies are struggling with these attempts because they lack a clear understanding of the psychological and social purchase motivations of consumers. This study compares and contrasts the two different purchase motivations of consumers: social influence and hedonic performance expectancy. A survey was conducted with 243 users of on-demand music streaming services. Our data analysis shows that social influence impacts consumer attitudes towards music streaming, which in turn drive purchase intention. On the other hand, continuance intention of paid music streaming is driven by hedonic performance expectancy of consumers, not consumer attitude. These results imply that the music industry needs to differentiate its approach to prospective and current customers of music streaming services.


Our article studies how initiatives oriented towards Quality and continuous improvement (e.g. Six Sigma, TPS-Lean, Operational Excellence) can support the development of systematic innovation, based on the hypothesis that the tools and good practices of Quality have reached their maturity after developing since the 40's, which does not happen yet with Innovation and its principles. To obtain general trends first, we study the evolution of the publications associated with the terms "quality" and "innovation" from 1990 to 2016 and then focus on the compatibility between the principles of operational excellence (ExOp) and Product-design innovation (IDP.) Initially, we observed that Quality related studies development rate is decreasing through time, supporting the assumption of maturity. This does not happen with Innovation related studies which are growing over time, making reasonable to assume that Innovation related research will reach and eventually surpass in quantity the Quality related research. Although we could observe that the ExOp and IDP have compatible general objectives, we discovered that it is not advisable to apply directly the principles of ExOp to the IDP, both for empirical and conceptual reasons. Within the conceptual reasons, stand out the potential conflict between the efficiency-orientation of the ExOp and the novelty-orientation of the IDP. This makes the IDP prone to taking risks in search of novelty and disruptive anticipation, in circumstances that the ExOp


Regulating the electron transport layer (ETL) has been an effective way to promote the power conversion efficiency (PCE) of perovskite solar cells (PSCs) as well as suppress their hysteresis. Herein, the SnO2 ETL using a cost‐effective modification material rubidium fluoride (RbF) is modified in two methods: 1) adding RbF into SnO2 colloidal dispersion, F and Sn have a strong interaction, confirmed via X‐ray photoelectron spectra and density functional theory results, contributing to the improved electron mobility of SnO2; 2) depositing RbF at the SnO2/perovskite interface, Rb+ cations actively escape into the interstitial sites of the perovskite lattice to inhibit ions migration and reduce non‐radiative recombination, which dedicates to the improved open‐circuit voltage (Voc) for the PSCs with suppressed hysteresis. In addition, double‐sided passivated PSCs, RbF on the SnO2 surface, and p‐methoxyphenethylammonium iodide on the perovskite surface, produces an outstanding PCE of 23.38% with a Voc of 1.213 V, corresponding to an extremely small Voc deficit of 0.347 V.


Information Technology (IT) professionals are tasked with problem solving and educating the user on the solution at hand as well as assisting the organization with the correct use of technology to ...


There is growing pressure on business leaders to assume social and political responsibilities beyond the rule of law. In this article we explore the role of leaders, more specifically that of CEOs,...


This paper studied the design of Guangzhou multimedia electronic atlas under the environment at TeleAtlas, especially the design of functional principle, data flow, quality control, data selection principles and processing, data classification and organization, for multimedia electronic atlas.These studies are on the base of past production summary of multimedia electronic atlas.


This paper examines phraseologisms with the lexeme tongue (jezik) and the target domain of linguistic action in the Serbian and English language. The method used was conceptual analysis, and phraseologisms are classified according to the concepts that form their meanings. Comparing the expressions we can conclude that there is a high degree of compatibility between the two languages, probably due to the universality of certain phenomena related to the basis of human functioning, as well as the human cognitive structure.


Objective: to describe and analyze patients with geotropic direction changing positional nystagmus
 Background: Horizontal Semicircular Canal (HSC) canalolithiasis is the second most common variant of positional vertigo (5-30[percnt]). The diagnosis maneuver is the head roll test which triggered a positional nystagmus which changes its direction according to the decubitus of the patient. The nystagmus of HSC canalolithiasis is transient and disappears after repetitive examination (fatigability). There is a subgroup of patients with a geotropic response with no latency neither fatigability (persistent geotropic positional nystagmus). Although the exact physipathology is unknown, one possible explanation could be a cupula with lower density than the surrounding endolymph (light cupula theory).
 Methods: Videoculography (VOG) studies reporting positive head roll test (between January 2014 and January 2015) were analyzed. Other causes of vertigo were ruled out.
Those cases with geotropic response were divided according to the characteristics of nystagmus.
 Results: 37 patients (21/16 F/M) with geotropic response were identified, the average age of the population was 68 years old. In 34 patients the duration of nystagmus was less than a minute (average 37 seconds) and in 3 cases nystagmus lasted until the end of registration. We observed absence of latency in all patients with prolonged duration. The onset of symptoms was longer than 3 months in cases with persistent nystagmus. Those patients with exhaustible nystagmus the average duration of the discomfort was 14.7 days. In 2 patients with presence of persistent geotropic nystagmus, a null plane at which the nystagmus disappears
 Conclusions: - In our subpopulation with possible light cupula syndrome the duration of symptoms was higher than in patients with canalolithiasis.
- We consider important to make an exhaustive evaluation of VOG studies with geotropic positional nystagmus responses. We also suggest to search for the null plane in atypical cases, that it will help in defining this syndrome. Disclosure: Dr. Bisonni has nothing to disclose. Dr. Videla has nothing to disclose. Dr. Norscini has nothing to disclose. Dr. Cristiano has received personal compensation for activities with Bayer, Biogen Idec, Merck, and Novartis.


This paper identifies the major effect on schools of the 1988 Education Reform Act. It describes how moves towards central control of the curriculum are balanced by an increase in the power given to governing bodies of individual schools. Then it traces the origins of the national science curriculum and analyses the changes that this curriculum is beginning to have in both primary and secondary schools. It concludes that the immediate impact upon classroom instruction has generally not been great but there are indications that the assessment procedures accompanying the curriculum changes are starting to have an influence on the way science is taught.


Professional landing pages have a significant role in increasing conversion rates of electronic marketing sites. The study attempted to identify this role and the criteria needed for creating a professional landing page that contributes to increasing conversion rates in the countries recently using electronic marketing such as Arab countries. There is no study addressing the promising Arab markets on the subject of electronic marketing. The study was conducted on the Saudi market; its electronic marketing sites suffer from low turnout. The study concluded that one of the main reasons for this decline is the ineffectiveness of an important tool of electronic marketing in these sites, which is landing pages. They either do not exist in these sites or lack the correct criteria. This study will help the administrators and owners of these sites to take care of this important tool, and how to create them professionally to enhance their electronic marketing sites distinctly.


Received: 30 March 2012. Accepted: 20 April 2012. ŒWIERCZEWSKI D., STROIÑSKI A. 2012. A new species of the genus Latois STCL, 1866 from Madagascar (Hemiptera: Fulgoromorpha: Flatidae). Acta zool. cracov., 55B(1): 65-77. Abstract. A new species of the family Flatidae Latois nigrofasciata sp. n. fromMadagascar is described and illustrated.


. Marine radiocarbon ( 14 C) is widely used to trace deep ocean circulation, providing insight into the atmosphere-10 ocean exchange of CO2 during the last deglaciation. Using two transient simulations with tracers of 14 C and ideal age, we found that the oldest ventilation age is not observed at the Last Glacial Maximum (LGM). In contrast, the model shows a modestly younger ventilation age during the LGM compared to present day, mainly due to a stronger glacial Antarctic Bottom Water (AABW) transport associated with sea ice expansion. Notably, the ocean ventilation age is significantly older around 14-12 ka compared to the age at the LGM, with deep Pacific waters playing a predominant role, primarily caused by 15 the weakening of AABW transport.


Suggestion of the ash flow mechanism as one of the major processes required to account for some features of lunar soil. First the observational background and the gardening hypothesis are reviewed, and the shortcomings of the gardening hypothesis are shown. Then a general description of the lunar ash flow is given, and a simple mathematical model of the isothermal lunar ash flow is worked out with numerical examples to show the differences between the lunar and the terrestrial ash flow. The important parameters of the ash flow process are isolated and analyzed. It appears that the lunar surface layer in the maria is not a residual mantle rock (regolith) but a series of ash flows due, at least in part, to great meteorite impacts. The possibility of a volcanic contribution is not excluded. Some further analytic research on lunar ash flows is recommended.


This paper introduces a recently developed dating technique based on the decay of ~(26)Al and ~(10)Be.The two radionuclides,with half lives 0.7 and 1.5 Ma respectively,are in situ produced by secondary cosmic-ray particles in quartz near the ground surface with a stable ratio of production rates.Their concentrations depend on the time of mineral's exposure to cosmic rays,which is in turn controlled by the erosion rate of the host rock.If quartz grains,after longtime exposure on the ground surface,are suddenly washed into a cave or deeply buried with at least ten meters of overburden to shield off cosmic rays,the production of ~(26)Al and ~(10)Be drastically slows or ceases and the inherited radionuclides decrease exponentially with time.Because ~(26)Al decays roughly twice as fast as ~(10)Be,the ~(26)Al/~(10)Be ratio decreases also exponentially with time.With a state-of-the-art accelerator mass spectrometry(AMS),it's possible to precisely determine the trace amount of ~(26)Al and ~(10)Be in quartz,from their ratio the sample's burial time can be deduced.This method is applicable in the range of 0.3 to 5 Ma,filling thus a "blind spot" of the Quaternary geochronology.With this technique,we studied the chronology of the low sediments at Zhoukoudian Location 1.The result indicates that the chronoloies of the Layer 10 may be approach 1 Ma.However,the samples were not purified sufficiently to obtain reliable data,because of the complexity of mines,especially the effect of feldspar.


A method for rapidly analyzing the γ spectrum obtained with Ge(Li) detectors was developed for a medium-size electronic computer. The analysis is based on the first derivative method, associated with a number of peak-shape tests. The effects of data smoothing and of changes in peak width were studied to determine the optimum conditions for spectrum analysis. The resulting computer program was subjected to various quality tests on the predicted values of the peak position and area. The results of the tests showed that the code thus developed works quite satisfactorily. The code requires 10 sec and a memory core of 29 k when using a FACOM 230–60 for the analysis of a 2,047 channel spectrum.


Development of rasi or rice made from cassava flour was developed in Cirendeu Village-Cimahi City. The activity requires a feasibility study analysis that is mobile and fast so that it can be implemented more easily in the field. Nowadays, information technology is developing very fast to support decision support systems that are mobile. Analysis of economic-based feasibility studies has been widely developed in the field, but often is still based on virtual laptops. The purpose of this research activity is to conduct a trial-based Android-based feasibility study for the development of constellations in Cirendeu Village, Cimahi City. The research activity method includes several stages including optimizing and developing constellation technology in the field, analyzing the laptop-based feasibility study, transforming the results of an Android-based feasibility study and testing the implementation of performance in the field. Based on the results of the analysis in the field, the results were obtained that the software was able to identify the feasibility and optimum capacity of the production business based on the results of input data for several parameters that had been identified based on the system. The feasibility of the constellation development efforts developed in Cirendeu Village-Cimahi City can be identified more easily by using android for further implementation at the field level. This technology can be used and replicated as a mobile software-based decision-making system approach.


For more than a decade now, cities have been experimenting with the various forms of organization for upper elementary grades. Industrial work, departmental teaching, duplicate schools, and junior high schools have appeared in constantly increasing proportions in the cities of the nation. It is true that the results of these innovations have not always been checked with scientific accuracy, but the whole movement has been very definitely under the scrutiny of thoughtful educators and an impressive body of educational literature has appeared as the result of this observation.


Paul Bourget, A committed writer, Yehoshua Mathias. ; In the France of the early twentieth century, Paul Bourget's figure is that of a successful novelist who became gradually a «committed author». A monarchist, deeply conservative, passionate defender of religion and the family as the vital bases of the social order, he thus became the bard of the bourgeois ethic faced with the destabilization of modernity.


Chapter 1 Functions and Graphs 1.1 Slope and Linear Functions 1.2 Polynomial Functions 1.3 Rational and Radical Functions 1.4 Trigonometric Functions 1.5 Trigonometric Functions and the Unit Circle Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Carbon Dioxide Concentrations Chapter 2 Differentiation 2.1 Limits and Continuity: Numerically and Graphically 2.2 Limits: Algebraically 2.3 Average Rates of Change 2.4 Differentiation Using Limits of Difference Quotients 2.5 Differentiation Techniques: Introduction 2.6 Instantaneous Rates of Change 2.7 Differentiation Techniques: The Product and Quotient Rules 2.8 The Chain Rule 2.9 Higher-Order Derivatives Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Rate of Epidemic Spread: SARS Chapter 3 Applications of Differentiation 3.1 Using the First Derivatives to Find Maximum and Minimum Values and Sketch Graphs 3.2 Using Second Derivatives to Find Maximum and Minimum Values and Sketch Graphs 3.3 Graph Sketching: Asymptotes and Rational Functions 3.4 Using Derivatives to Find Absolute Maximum and Minimum Values 3.5 Maximum-Minimum Problems 3.6 Approximation Techniques 3.7 Implicit Differentiation of Related Rates Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Polymorphism Chapter 4 Exponential and Logarithmic Functions 4.1 Exponential Functions 4.2 Logarithmic Functions 4.3 Applications: The Uninhibited Growth Model, dP/dt = kP 4.4 Applications: Decay 4.5 The Derivatives of ax and logax Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Maximum Sustainable Harvest Chapter 5 Integration 5.1 Integration 5.2 Riemann Sums and Definite Integrals 5.3 Fundamental Theorem of Calculus 5.4 Properties of Definite Integrals 5.5 Integration Techniques: Substitution 5.6 Integration Techniques: Integration by Parts 5.7 Integration Techniques: Tables and Technology 5.8 Volume 5.9 Improper Integrals Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Estimating Dinosaur Mass Chapter 6 Matrices 6.1 Matrix Operations 6.2 Solving Linear Systems of Equations 6.3 Finding a Matrix Inverse and Determinant 6.4 Computing Eigenvalues and Eigenvectors 6.5 Solving Difference Equations Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Population Growth Chapter 7 Functions of Several Variables 7.1 Functions of Several Variables 7.2 Partial Derivatives 7.3 Maximum-Minimum Problems 7.4 An Application: The Method of Least Squares 7.5 Multiple Integration Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Stocking Fish Chapter 8 First-Order Differential Equations 8.1 Differential Equations and Initial-Value Problems 8.2 Linear First-Order Differential Equations 8.3 Stability of Autonomous Differential Equations 8.4 Separable Differential Equations 8.5 Numerical Solutions of Differential Equations Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Larvae and Forest Defoliation Chapter 9 Higher-Order and Systems of Differential Equations 9.1 Higher-Order Homogeneous Differential Equations 9.2 Higher-Order Nonhomogeneous Differential Equations 9.3 Systems of Linear Differential Equations 9.4 Matrices and Trajectories 9.5 Models of Population Biology 9.6 Numerical Methods Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Epidemics Chapter 10 Probability 10.1 Probability 10.2 Multiplication Trees and Bayes' Rule 10.3 The Binomial Distribution 10.4 Expected Value and Standard Deviation for Discrete Random Variables 10.5 Continuous Random Variables 10.6 Poisson Process 10.7 The Normal Distribution Summary and Review Test EXTENDED LIFE SCIENCE CONNECTION: Axenic Cultures Appendix A: Review of Basic Algebra Appendix B: Functions Tables Integration Formulas Areas for a Standard Normal Distribution Answers Index


The effects of inclined angle on the heat transfer of radiators under natural convection are analyzed with experiment and numerical simulation, there are three radiators with straight fin, oblique fin and pin fin respectively (based on 150 × 150 × 45mm). The numerical simulation could agree with the experiment. The straight fin radiator could provide the best heat dissipation performance under experimental conditions and normal installation angle. The pin fin radiator has the largest heat transfer coefficient, around 7 W/m2·K. The influence of deflection angle is discussed on the heat dissipation capability of the radiator. The heat dissipation of the pin fin radiator is less sensitive to the gravity direction than the straight fin and oblique fin ones.


Objective research the reasonable treatment of hepatogenous diabetes. Methods Thirty hepatogenous diabetes patients were assigned into 2 groups according to financial situation: 19 patients were injected regular insulin before half an hour of three meals, 16 patients were injected lispro before three meals. Observed The control of blood glucose and the occurrence of hypoglycemia were. Results The lispro is better than regular insulin in the control of blood glucose and has the lower occurrence in hypoglycemia. Conclusion Lispro is the best choice for the treatment of hepatogenous diabetes patients.


Nanoscale laser-induced periodic surface structures in thin metal films (of the size of the optical penetration depth) is a yet unexplored area that is expected to open new routes for laser patterning and a wealth of exciting applications in optics, photonics, and sensing. In contrast to the common belief that excitation of Surface Plasmon Polaritons (SPPs) on the air/metal interface plays the dominant role in the features of the induced topographies, in this work, we demonstrate that the excitation of coupled SPPs in both air/metal and metal/substrate interfaces (Fig. 1a), along with other parameters such as the thickness of the material, the photon energy, and the substrate refractive index, dictate the spatial modulation of the absorbed energy. Results are shown for Au while the methodology can be followed for any metal. A detailed theoretical analysis of the excited plasmonic waves and a multiscale modelling of laser-induced physical phenomena manifests that depending on the laser conditions and thickness of the irradiated solid, topographies with periodic features of diverse sizes (ranging from $\lambda_{L}/3$ to $\lambda_{L}$, where $\lambda_{L}$ stands for the laser wavelength) and different orientation can be realized (Fig. 1b) [1].


A subgroup of B-cell chronic lymphocytic leukemia (CLL) patients develop a more aggressive form of the disease characterised by ZAP70 expression and unmutated IgVH genes. Mutational inactivation of p53 and ataxia telangiectasia-mutated kinase (ATM) are frequent in these patients and confer chemo-resistance. Overexpression of DNA-dependent protein kinase (DNA-PK) correlates with clinical resistance to Chlorambucil (CLB). Thus, alterations in DNA damage signaling pathways are associated with drug resistance. We previously demonstrated that inhibition of DNA-PK sensitizes leukemia cell lines to DNA topoisomerase II poisons and ionising radiation (IR) by inhibition of non-homologous end joining of DNA double strand breaks (DSB). Loss of ATM function compromises the complementary DSB repair pathway, homologous recombination. We hypothesised that repair of DNA damage induced by CLB and Fludarabine may be mediated in part via DNA-PK and ATM and that inhibiting these enzymes would sensitize CLL cells to these agents. NU7441 and KU55933 are potent small molecule inhibitors of DNA-PK and ATM respectively, developed in collaboration with KuDOS Pharmaceuticals (Cambridge, UK). We used these inhibitors in ex-vivo drug combination experiments on CLL lymphocytes derived from a cohort of 60 patients. Lymphocytes were treated with CLB, Fludarabine, Cyclophosphamide, Mitoxantrone or Etoposide in the presence or absence of NU7441 (1μM) or KU55933 (10μM). We observed a concentration-dependent decrease in viability in response to these drugs (XTT assay), and in 70% of cases this decrease was potentiated in the presence of NU7441 (e.g. CLB 2–20 fold potentiation, Fludarabine 2–14 fold). Drug induced caspase 3/7 activity was further increased by NU7441, indicating that DNA-PK inhibition increased cell death via apoptosis. Early data shows that KU55933 also sensitizes tumors to these agents. Increased drug-sensitivity by NU7441 or KU-55933 was independent of disease stage, progression or CD38 status. We quantified γH2AX foci formation (a surrogate marker for DSB) after drug treatment. Fludarabine induced γH2AX foci formation (7 tumors), and this novel observation suggests that Fludarabine induces DSB in quiescent CLL cells. NU7441 increased the number of fludarabine-induced γH2AX foci, implicating DNA-PK as a mediator of DSB repair following Fludarabine treatment. To investigate the significance of p53 functionality on sensitization by inhibitors, we stratified 14 samples from the cohort according to ability to upregulate p21 after IR treatment (FACS analysis). 6/10 cases that displayed impaired p21 upregulation (associated with defects in p53 or ATM function) were sensitized to either CLB or fludarabine by NU7441. 4/4 cases with normal p21 response were sensitized by NU7441. These data are key, since they suggest that NU7441 may have efficacy in cases with p53 dysfunction, a group of tumors representing poor prognosis, drug-resistant patients. Current studies are characterising the cohort (11q,17p deletions) and measuring kinetics of DNA DSB formation and repair. Future studies will further investigate effects of targeting ATM in CLL, and targeting DNA-PK in ATM- defective tumors. Use of DNA-PK and ATM inhibitors represents a targeted and novel therapeutic approach for poor prognosis CLL.


This article develops analysis about the plurisignification of the ideographic signs on the work Lavoura arcaica , starting out from the proposition of some hypotheses that justify why punctuation can - in relation to words - be the figurativeness of the discomposedness that the book thematizes. Starting from the principle that the unstable character encircling the use of punctuation favors the work with the semiotic mode of signification, - that one belonging to the impulses - the reflection presents some studies of cases by means of which it is possible to observe that the ideographic signs end up conducting the rhythm, melody, fault, silence and the language contraction, while the phonographic signs are conducted by the symbolic. Therefore, from the tension between word and punctuation, the analysis goes on to approach the relationship between instinct/reasoning, affection/law, analogical/digital, personal/social, lawsuit/trial.


The design standard for the thickness of reinforced roadbed is divided into high-speed and conventional railroad because dynamic characteristics of train loadings differ depending on the train speed. Due to the national plan for increasing the train speed for both conventional and new railroad lines, it is necessary to examine the applicability of concrete tracks and feasibility of the train speed increase on the conventional lines with the current thickness of the reinforced roadbed. In this study, a real-scale test was performed to monitor the dynamic characteristics of the reinforced roadbed with a thickness of 20㎝ and the train speed of 200㎞/h, 300㎞/h, and 400㎞/h. The test results were then compared with the design code to investigate the applicability of the conventional reinforced roadbed when the trains operate with higher speed.


We demonstrate the prospect for on-chip generation of diffraction-free space-time wave packets. This can be accomplished by entangling the spatial and temporal degrees of freedom on an integrated platform.


AGR fuel cladding in reactors operating at temperatures between 350°C and 520°C undergoes radiation-induced segregation, which produces compositional profiles at grain boundaries. As a result of this sensitization, the material becomes susceptible to intergranular attack when exposed to moist air environments. This paper presents evidence for incubation periods that precede corrosion of stressed sections cut from sensitized fuel pins. The interaction of the stochastic cracking process and the test sample area is also considered in relation to penetration rates.