Over the last decade, the interactions between neoplastic lymphocytes and the tumor microenvironment, especially the immune system and stromal cells, have proven to be key in the pathogenesis of B-cell neoplasms, including chronic lymphocytic leukemia (CLL), acute lymphoblastic leukemia, Hodgkin and Non-Hodgkin lymphomas (NHL), and multiple myeloma. In these malignancies, tumor cells in the bone marrow, lymph nodes, spleen or in peripheral blood are by nature surrounded by immune cells such as B and T lymphocytes, regulatory T cells, monocytes, macrophages, and neutrophils, which were shown to harbor tumor-supportive and immunosuppressive features. Hence, understanding the complex crosstalk between malignant and non-malignant cells in lymphoid malignancies is crucial to design innovative therapeutic strategies, including immunotherapy. To this end, an in-depth characterization of tumor-associated immune cells and other accessory cells and their complex interactions with malignant cells within the tumor microenvironment will be crucial to identify new therapeutic targets and to develop successful combination treatment strategies including immunomodulatory drugs. In this first volume, 13 articles explore disease biology and signaling in different B-cell malignancies and their connection to the microenvironment. CLL cells are mainly quiescent in the peripheral blood but a small proliferative pool exists in the lymph nodes. In a timely review (1), Haselager, Kater and Eldering explain the different signals implicated in CLL proliferation and their connections to the lymph node microenvironment. They stress on the importance of the B cell receptor (BCR) activation in CLL cell growth and the therapeutic targeting of this pathway using inhibitors of the Bruton's tyrosine kinase (BTK). However, in vitro BCR triggering is unable to generate significant cell proliferation, highlighting the complexity of the in vivo situation and the need for better in vitro modelling to mimic the disease. This is the main focus of a mini review (2) by Scielzo and Ghia in which they highlight the current lack of a suitable culture model in B-cell malignancies compared to solid tumors. They detailed the current innovation regarding static and dynamic 3D culture in which accessory cells can be


An operating system usually distinguishes between threads managed by a software scheduler and interrupt service routines, scheduled and dispatched by an interrupt controller. This paradigm has inherent problems for real-time systems as low-priority interrupt routines can interrupt high-priority threads. The Sloth concept proposes to overcome this issue by implementing both interrupt handlers and threads as interrupts, which are scheduled and dispatched by hardware. This eliminates the difference between the two types of control flows by introducing a unified abstraction. With this simplification, scheduling and dispatching of threads can be managed completely by the interrupt subsystem in hardware. In the scope of this thesis, this Sloth concept was implemented as an interrupt-driven operating system conforming to the OSEK specification on the ARM Cortex-M3 microcontroller platform. This entails the investigation how the Sloth concept can be implemented with the provided hardware functionality and how the hardware components need to be utilized. This finished implementation is evaluated and compared to another operating system with a software-based scheduler in order to confirm the positive effect of this concept on the performance of thread management. Additionally, this thesis examines the influences of the hardware architecture on the design and implementation of Sloth.


Alkyl-capped and alkyl/alkoxy-capped silicon nanocrystals have been prepared by the oxidation of magnesium silicide with bromine. High-resolution transmission electron microscopy confirmed the crystalline nature of the nanoparticles and provided an average diameter of 4.5 (2.0) nm for the alkyl-capped and for the alkyl/alkoxy-capped nanoparticles. Energy-dispersive X-ray spectroscopy showed that the nanoparticles are composed of silicon, with no evidence of unreacted bromine. FTIR spectra were consistent with alkyl- and alkyl/alkoxy-capped surfaces. Fluorescence spectroscopy indicated strong ultraviolet-blue photoluminescence, which was attributed to both quantum confinement and surface termination. These nanoparticles displayed long-term stability and no degradation of the photoluminescence was observed for a period of 1 year.


Background  Safety of tumour necrosis factor (TNF) antagonists is a primary concern for clinicians prescribing them to patients with psoriasis.


Use of a combination comprising at least two types of nanoparticles of material exhibiting Raman, where each effect, at least two types of nanoparticles are in a dispersed state or form agglomerates of between 2 and 500 nanoparticles, where said agglomerates have a size less than 2 microns, in the preparation or marking of a document, article or security element, characterized in that: - at least two types of nanoparticles differ in their chemical composition, in its crystal structure, in shape, in size and / or their dispersed or agglomeration state, and - when they differ in their dispersed or agglomeration state, one of the types of nanoparticles is in a dispersed state and the other is forming agglomerates of between 2 and 500 nanoparticles, or both are forming agglomerates containing a different number of nanoparticles, wherein said nanoparticles number is between 2 and nanoparticles 500


In the automatic sorting process, overlapping translucent and flexible workpieces on the conveyor belt, blurring the imaging edge features of translucent and flexible workpieces is a challenge to locate the upper and lower workpieces spatially, we propose a method for locating translucent and flexible workpieces spatially under the overlapping environment in conjunction with the most common automatic sorting of translucent and flexible workpieces such as infusion tube drip buckets. Firstly, we propose a rectangular surface light source based on 650 nm band and monocular CCD for imaging translucent workpieces such as infusion tube drip buckets and optimize the imaging parameters. Secondly, we study a feature matching recognition algorithm for flexible workpieces that are prone to deformation, construct a mapping relationship between the position of overlapping layers and imaging quality of translucent and flexible workpieces such as infusion tube drip buckets based on clarity and information entropy, and establish The mapping relationship between the position of the overlapping layers and the imaging quality of translucent and flexible workpieces such as infusion tube drip buckets is constructed based on clarity and information entropy, and a local spatial coordinate conversion model is established. Finally, the spatial positioning coordinates of overlapping and non-overlapping translucent and flexible workpieces in the local coordinate system are identified, and the results show that the imaging method and theory can be effectively applied to the identification of overlapping and spatial positioning coordinates in the automatic sorting of translucent workpieces such as infusion tube drip buckets.


To cope with the increasing demand for customized products, manufacturing processes become more adaptive and flexible, for example by using layouts that can be easily rearranged to adapt an assembly process with respect to the produced items. Specialized layout planning software is used to manage the multitude of possible arrangements and their effects in the production pipeline. However, not all conditions and dependencies can be tracked, modeled, and correctly interpreted in the virtual setup, making it challenging for domain experts to foresee real-world effects. To address this challenge, we contribute an immersive analytics approach that extends an existing factory layout planning tool. It employs augmented reality technology to superimpose existing setups and facilities for a more lifelike impression on production line layouts. The interactive planning is enhanced by automated layout suggestions using a genetic algorithm as well as automated layout comparison. A case study demonstrates the applicability in a realistic scenario.


Competitive exams, selection, and placement of high-ranking public officials used to be resorted only by Vietnam's feudal dynasties. After half a century of abandonment, this practice seems to have made its spectacular comeback in the recent decade. In a quest for high caliber public personnel, the Vietnamese government believes that competitiveness-base exams would help select, recruit and place right public servants into the right job. This research was conducted to figure out to what extent the selected high-ranking post holders were different from the public service employers. Based on face-to-face interviews with candidates and the heads of public services employers who were going to place the selected ones onto the managerial posts, data were gathered for Structural Equation Modeling (SEM) analysis with the use of structured 5 point-Likert scale questionnaire in the field surveys. Findings showed that there existed a difference in the perceptions towards the fairness of the competitive exams among these two types of interviewees. By comparing SEM coefficients, several recommendations were drawn for policy makers and managers to modernize this type of recruitment, selection and placement of managerial public servants on the intended job positions.


The 'comprehensive study on the costs and benefits of unification,' which began in 2011 as a five-year research is composed of domestic and international aspects. Regarding the international aspect, each country's perception and role in unification has been analyzed for the four surrounding countries in 2013 and for the major countries of the G20, excluding the previously mentioned four, in 2014. The international study in 2015, which is the final year, tries to come up with a comprehensive analysis on the international community's perception and role in unification based on the outcome of studies conducted up to now. This study is characterized as expanding the scope of research beyond domestic level to international level. Each country's perception and role has been analyzed in-depth by way of forming a collaborative research system with experts in the surrounding four countries having a high stake in the unification. This study also stands out as expanding the unification cost-benefit study horizon internationally by looking into the effects and perceptions of the major G20 countries. The four surrounding countries show a tendency to think that unification would in general bring benefits to them according to the route of the guiding type unification on whose premise the study is based. On the other hand, for the U.S. and China, who confront each other in terms of diplomacy and security in Northeast Asia, it is confirmed there are concerns over unified Korea becoming a new competing factor in regional security. The ten major countries of the G20 in general have expressed concern over increased instability that might arise from the unification in the Korean Peninsula. It is expected that the ten major countries will be quiet supporters of a peaceful unification rather than be directly involved. Unification studies regarding the costs and benefits in an international perspective should be continued based on this study and important implications should be derived to identify how unification should be approached actively on the diplomatic front.


The purpose of this paper is to develop a new technique for estimating the two-dimensional (2D) direction-of-arrivals (DOAs) of coherently distributed (CD) sources, which can estimate effectively the central azimuth and central elevation of CD sources at the cost of less computational cost. Using the special L-shape array, a new approach for parametric estimation of CD sources is proposed. The proposed method is based on two rotational invariance relations under small angular approximation, and estimates two rotational matrices which depict the relations, using propagator technique. And then the central DOA estimations are obtained by utilizing the primary diagonal elements of two rotational matrices. Simulation results indicate that the proposed method can exhibit a good performance under small angular spread and be applied to the multisource scenario where different sources may have different angular distribution shapes. Without any peak-finding search and the eigendecomposition of the high-dimensional sample covariance matrix, the proposed method has significantly reduced the computational cost compared with the existing methods, and thus is beneficial to realtime processing and engineering realization. In addition, our approach is also a robust estimator which does not depend on the angular distribution shape of CD sources. Copyright © 2014 IFSA Publishing, S. L.


women are treated fairly, i.e., changes that take into account the reality of women's marginalized status. In chapter 7 the authors cite two critical variables that frustrate responsive mental health treatment for incarcerated women. The first entails finding a "safe space" or "therapeutic niche" in the prison setting. The second concerns poorly screened, selected, and trained staff who may unknowingly undermine treatment protocols. In spite of these frustrations, however, evidence supports continuing gender-responsive treatment programs, which have proven successful in providing "relief' to female inmates or in teaching coping skills necessary for life outside prison walls. Distinguishing between programs forwomen and gender-responsive programming in chapter 8, the authors note the promise of genderresponsive programs that "cut at" the pathways to criminology that are particular to female offenders. Using an "empowerment" model, these programs focus on skill building, rather than on pathological deficits, in an effort to develop the competencies needed for living independently, or, as the authors maintain, to "shore-up" women's vulnerability in the face of situations, circumstances, and perceptions that propel them along criminological pathways. As an alternative to simply running "programs in niches," the authors reference a trend currently taking place in Canada, namely, prisons specifically designed for women. However, developing such a system. complete with appropriate programming and professional staff, is contingent upon two critical factors: a receptive political climate and the availability of multiple sources of financing. The last chapter in the book summarizes the systematic ways in which females continue to be marginalized in the criminal justice system and provides final compelling evidence to discount the "myths" about and the stereotypes of women in prison. Once more, the authors insist that the realities offemale offending must be taken into account to ensure "effective practices" throughout the criminal justice system. Sensitizing the public, the courts, and the correctional system to these realities is the method that the authors have used to challenge what they describe as a society that "prides itself on justice." Written from a feminist perspective, the book is valuable for reasons other than its identification of structured inequality in the criminal justice system. It is a practical anthology of cogent evidence that needs to be considered by those who are concerned with the increase in female offending and the most effective strategies for combatting this particular phenomenon.


29 It was an icy February day. I was sitting in my office preparing my presentation for the forth coming 37th Congress of the Polish Society of Internal Medicine, which was scheduled for April 12–14, 2012. Suddenly, the telephone rang and I immediately recognized the voice of my friend, Peter Gajewski, the nearest collabora tor of Professor Andrew Szczeklik. "What hap pened? How can I help you?" I asked Peter. Af ter a while of complete silence Peter said: "Fran cis, I have a very bad message for you – Andrew died this morning". There were no more ques tions and answers. This message completely para lyzed my voice. I was sitting immobilized at my desk while 50 years of friendship with Andrew flashed through my brain. This friendship start ed in the early 1970s, when Andrew, a young doc tor, worked on the diagnostic value of gamma gluatamyl transpeptidase and cobalt activat ed acylase together with Dr M. Orłowski and A. Szewczuk. As I too was inter ested in clinical enzymology, our friendship strengthened from year to year. Beginning with 1979, he became the author of a chapter in the textbook of in ternal medicine, which was edited by me during the next 25 years, and which, after 8 editions, was replaced by a large textbook – Internal Medicine under the editorship of Andrew, and which in an updated version appears every year since 2005. His medical textbook is complemented by two lit erary masterpieces – Catharsis: on the Art of Medicine and Kore: on sickness, the sick, and the search for the soul of medicine, which were already pub lished in several foreign languages. Andrew was not only an experienced teach er but also a leading scientist in the field of as pirin asthma, well known all over the world. He was awarded the degree of doctor honoris causa by five universities, the honorary membership of more than ten inter national scientific societ ies, and numerous esteemed inter national hon ours and distinctions. His sudden heart arrest left thousands of be reaved patients, for whom he always was the A painful leave taking


Leadership is key to employee performance, and leadership in the universities is responsible for the performance of employees in their institutions. This article seeks to find out the contribution of university leadership in improving employee performance. The researcher adopted both the survey and purposive sampling technique with a 5-point Likert Scale questionnaire to solicit data. The article relied on Hicks's (2015) key indicators for improving employee performance. The findings reveal that the employee of the universities has the requisite skills to match their task, and also understand the goals of the institutions, however, the leadership of the universities need to attend to the challenges of incentives for staff, feedback on performance, and the processes of accessing scholarship for training.


In modern era or day to day life cumulative toxicity (Dushivisha) increases the need for antioxidants as the body attempts to neutralize the harmful substances. The factors such as Viruddhahara and Ahitahara, fast foods and cold beverages, alcohol, tobacco, pesticides, metals and pollutants etc. can be considered under Dushivisha (cumulative poison). Aggravate Dosha vitiate the Dhatu (elements of body) specially Rakta Dhatu, it deposits in body tissues due to mild potency in nature, it covered by Kapha dosha and produces many diseases in favorable condition. Acharya Sushruta in Kalp sthana mentioned Ajeya Ghrita as a best remedy for the management of Dushivisha derived diseases. The content of Ajeya ghrita have Laghu, Rukhsha, Tiksna, Katu, Ushna, Kushthaghna, Krimighana Vishghna and antioxidant properties can help the breakdown the pathogenesis of Dushi visha. This formulation is given in 30 patients which is divided in two group having 15 patients in each group in oral dose of 12gm BD with lukewarm water for 30 days with follow up 30 days. Patient having sign and symptoms of fever, Kotha (skin allergies), Kasa (cough), Trishna (increased thirst), abdominal pain, recurrent Avipaka (indigestion)/ Arochak (anorexia), recurrent Chardi (vomiting)/ nausea, recurrent Shirahshool (headache)/ dizziness, recurrent Jwara (fever), recurrent Atisara (diarrhea), premature aging (wrinkling of skin, greying and loss of hair etc.), Smritinasha (loss of memory), recurrent Daurbalya (weakness), result found 1 patient (6.67%) were completely remitted in Group A while group B not found. 4 patients (26.66%) Group A, while in Group B, 3 (20%) were moderately improved respectively. 5 patients (33.33%) were no relief in group A and 4 (40%) in group B, no relief in any symptoms.


Abstract INTRODUCTION DURING the course of an unpublished study to evaluate environmental factors affecting rate of egg production, it was deduced that age at first egg among genetically similar pullets should be closely related to daily hours of illumination. As a corollary, winter hatched pullets should mature earlier than spring hatched pullets. Evaluation of these relationships may enable poultry breeders to correct their genetic selection for early maturity in accordance with date of hatch or persuade them to limit comparisons to groups of pullets hatched during a very limited period. Selection is effective in proportion to the degree with which it reflects genetic variation rather than variation due to environment. Several studies of the effect of date of hatch on age at first eggs are summarized by Lippincott and Card (1939) and Jull (1940). Conclusions as to the effect of date of hatch on age at first egg drawn from these . . .


Objective To explore the effect of early systemic phased exercise post mastectomy on the recovery of activities of daily living.Methods 100 patients who received modified radical mastectomy were assigned to the experimental group and control group with 50 patients in each group.They all accepted routine nursing,and the experimental group accepted early systemic phased exercise in addition.They were assessed with range of motion(ROM) of shoulder and modified Barthel Index(MBI).Results ROM of shoulder improved in 90% of the experimental group and 70% of the control group(P0.05).MBI was(84.5±18.2) in the experimental group and(51.8±16.6) in control group(P0.05).Conclusion Early systemic phased exercises may promote the recovery of the affected arm for the patients post mastectomy.


Crimes are common social problems that affect the quality of life, economic growth and reputation of a country. In smart cities, the aim is to reduce crime rates using Information and Communication Technologies (ICT), specifically with the use of Internet of Things (IoT) technology in combination with legacy information systems, in order to obtain data automatically. In this paper, we propose an approach based on deep learning for the classification of incidents of a crime of public safety through predictive analysis. The predictive model is based on a neural network Long Short-Term Memory (LSTM), trained with a small group of attributes, enabling the prediction of the class label in the validation stage, with a high percentage of prediction accuracy. The proposed approach is evaluated through a big data set (real data) of type open data, which contains historical information about the crimes of a smart city. Keywords-LSTM; Prediction; Neural Network; Data Classification; Smart City.


in Ukraine in 2021, the incidence of benign prostatic hyperplasia (BPH) was 321.6 per 100,000 population. Almost 17,000 operations on prostate gland have been performed, a significant proportion of which are transurethral resection (TURP). It has been proven that the most frequent early complications after surgical interventions on the prostate gland are the development of an acute inflammatory process in the genitourinary organs, bleeding from the area of there removed hyperplastic tissue of the prostate gland. Inflammatory diseases of the urogenital tract in men are characterized by a variety of etiological agents, the presence of mixed infections, and the growing importance of pathogens of sexually transmitted diseases. To improve the results of TURP in patients with BPH complicated by acute urinary retention by optimizing antibacterial prophylaxis of postoperative complications in the early postoperative period. The study is based on the results of the analysis of surgical treatment of 179 patients with BPH complicated by acute urinary retention who underwent TURP. The age of the patients varied from 51 to 84 years, the average age was 64.9±5.1 years. Patients were divided into two groups: Group I – 85 operated patients who were prescribed ceftriaxone (1.0 parenterally once a day) in the early postoperative period; Group II – 94 patients, in the early postoperative period got levofloxacin (500 mg IV for 3-5 days with subsequent transition to oral administration, once a day). The analysis of the obtained data established that in the early postoperative period 43 (24.1%) patients had complications. The most frequent complication was long-term macrohematuria, which was observed in 23 (12.9%) patients. Exacerbation of chronic pyelonephritis occurred in 13 (7.3%) operated patients, acute urethritis developed in 7 (3.9%) patients, acute orchiepididymitis was observed in 9 (5.0%) patients. The over all frequency of complications in patients with BPH who received levofloxacin in the early postoperative period was statistically significantly lower than in patients who were prescribed ceftriaxone. In particular, the use of levofloxacin in patients of the II group, with the aim of antibiotic prophylaxis of postoperative complications after TURP, made it possible to reduce the frequency of the latter by 60% (1.6 times), in relation to the patients of the I group. The use of levofloxacin for the prevention of early postoperative complications after TURP inpatients with BPH complicated by acute urinary retention improves the results of surgical treatment by reducing the frequency of complications in the postoperative period by 60%.


A few ABET-experienced faculty members typically guide the ABET documentation process. Consequently, this becomes an abstract process that is of little concern to remainder of the faculty members. When one considers that ABET accreditation process can indeed provide an impetus for continuous improvement, which in turn, can make the next ABET accreditation cycle relatively smooth, the department's wider community becomes an indispensable resource to involve and learn from. A typical department has many relevant on-going concurrent activities. Synergistic interactions among these can help address the overall goal of continuous improvement, and in turn secure ABET accreditation. KISMET (Keep It Simple and Measurable for Effective Teaching) takes a holistic approach to make ABET documentation a living document and to empower all faculty and staff members to participate, discuss, improve, and benefit from it. We have benefitted from the use of KISMET. We use OPM (object process methodology) to graphically present this in our paper.


Our study aims to investigate the dynamics of conventional memory T cells (Tconv) and regulatory T cells (Treg) following activation, and to explore potential differences between these two cell types. To achieve this, we developed advanced statistical mixed models based on mathematical models of ordinary differential equations (ODE), which allowed us to transform post-vaccination immunological processes into mathematical formulas. These models were applied on in-house data from a de novo Hepatitis B vaccination trial. By accounting for inter- and intra-individual variability, our models provided good fits for both antigen-specific Tconv and Treg cells, overcoming the challenge of studying these complex processes. Our modeling approach provided a deeper understanding of the immunological processes underlying T cell development after vaccination. Specifically, our analysis revealed several important findings regarding the dynamics of Tconv and Treg cells, as well as their relationship to seropositivity for HSV-1 and EBV, and the dynamics of antibody response to vaccination. Firstly, our modeling indicated that Tconv dynamics suggest the existence of two T cell types, in contrast to Treg dynamics where only one T cell type is predicted. Secondly, we found that individuals who converted to a positive antibody response to the vaccine earlier had lower decay rates for both Tregs and Tconv cells, which may have important implications for the development of more effective vaccination strategies. Additionally, our modeling showed that HSV-1 seropositivity negatively influenced Tconv cell expansion after the second vaccination, while EBV seropositivity was associated with higher Treg expansion rates after vaccination. Overall, this study provides a critical foundation for understanding the dynamic processes underlying T cell development after vaccination.


The Pylon of Xinjiang Cable-Stayed Bridge has a special geometric form, of which the anchorage zone adopts the steel-concrete composite structure with built-in steel anchorage box. To investigate the mechanical behavior, the refined 3D finite element model has been established with the shear nails of steel anchorage box simulated. The stress conditions of steel anchorage box and concrete under prestressing bar and stayed cable forces have been then studied. The bearing proportion at the anchorage zone for the horizontal component of cable force has been calculated. Results indicate that the overall mechanical performance of the anchorage zone is excel, which can be a reference for designing of similar structure.


FIELD: aircraft engineering; rocketry. SUBSTANCE: invention can be used in guided flying vehicles. Proposed controlled solid-propellant rocket engine has combustion chamber, nozzle, solid propellant charge, pressure pickup built into combustion chamber carried electronic computer, thrust control unit with actuating mechanism and hydraulic damping unit. Combustion chamber is furnished with igniter installed in its bottom and temperature pickup. Hydraulic damping unit contains nozzle, flow rate meter, electromagnetic valve installed on pressure line of pipeline, pneumohydraulic accumulator, part of which is filled with liquid coolant and other part, with solid propellant, and liquid coolant pressure pickup. Travel pickup is installed on rod of actuating mechanism of thrust control unit. Engine is furnished with two control subsystems. First subsystem includes thrust control unit actuating mechanism, pressure and temperature pickups fitted in combustion chamber housing and travel pickup installed on rod of thrust control unit actuating mechanism. All pickups of first subsystem are connected with electronic computer of vehicle. Second subsystem includes pneumohydraulic accumulator of hydraulic damping unit and liquid coolant pressure and hydraulic damping unit flow rate pickups. Liquid coolant pressure pickup and hydraulic damping unit flow rate pickup are connected with electronic computer of flying vehicle. EFFECT: provision of thrust control of solid-propellant rocket engine and reliable switching off. 2 dwg


The article focuses on autoaggressive behaviour in the context of victimisation risks. The authors consider a number of approaches that define autoaggressive manifestations in Russian and foreign psychology. It is noted that a tendency towards self-aggression may be induced by various causes found within an individual's personality and in the external environment. Particularly, the efforts of the parents to restrain and control a child's aggression by using corporal punishment only reinforce and increase the risk of self-injurious behaviour.
The main purpose of the research is to study autoaggression as a predictor of victim behaviour.
In order to address the issue identified as the main focus of the study, the authors present the results of empirical research conducted at Novosibirsk State Pedagogical University on a sample group of students, both male and female, aged 18–23 years. In total, the study involved 70 people.
Regression analysis was applied to determine the predictors contributing to different manifestations of victim behaviour. As a result, the propensity for non-critical behaviour was linked to neurotic spontaneous aggression, injurious reactive aggression, and suppression of anger. The tendency towards highly social victimisation behaviour was connected to anger, irritability, reactive aggression, and self-injurious behaviour. The propensity for dependent and helpless behaviour correlates with the levels of hopelessness, inhibition of aggression, and suppression of anger. The tendency towards self-injurious behaviour and self-destruction is influenced by auto-aggression, depression, irritability, and inhibition of aggression. In conclusion, the collected results suggest that there is a set of variables associated with the different manifestations of victim behaviour.


In this paper,we conducted a comprehensive analysis on the energy and electricity consumption of the food industry.Based on the analysis on the energy and electricity consumption characteristics of the food industry,we give the measures and suggestions on the promotion of rational use of energy and electricity in China's food industry,and provide the basis for energy-saving and electricity-saving.


This study examined whether consumers' purchase intentions were influenced by the type of green
marketing communications message they were exposed to, and whether this effect was moderated by their
level of green attitude. A sample of university students (N=171) were shown an ad stimulus promoting a
neutral benefit, a personal benefit or a generic environmental benefit to environmental purchase
behaviour. Participants' purchase intention was measured along with their level of green attitude. Results
showed that the level of environmental affect felt by participants moderated the effect of the ad stimuli.
The findings demonstrate that purchase intention for green products is affected by consumers' affect
towards the environment; marketers of green products could therefore appeal to the emotionality of
consumers.


In a two-phase anaerobic digestion process, enhanced biogas production and organic pollutant removal depend on the stability and performance of the hydrolytic–acidogenic and methanogenic phases. Additionally, the hydrolytic–acidogenic phase is a rate-limiting step, which calls for the further optimization of operating parameters. The objective of this study was to optimize the operating parameters of the hydrolytic–acidogenic reactor (HR) in the two-phase anaerobic digestion treating slaughterhouse wastewater. The experiment was carried using bench-scale sequential bioreactors. The hydrolytic–acidogenic reactor operating parameters were optimized for six different hydraulic retention times (HRTs) (6–1 day) and organic loading rates (OLRs) (894.41 ± 32.56–5366.43 ± 83.80 mg COD/L*day). The degree of hydrolysis and acidification were mainly influenced by lower HRT (higher OLR), and the highest values of hydrolysis and acidification were 63.92% and 53.26% at an HRT of 3 days, respectively. The findings indicated that, at steady state, the concentrations of soluble chemical oxygen demand (SCOD) and total volatile fatty acids (TVFAs) decrease as HRT decreases and OLR increases from HRTs of 3 to 1 day and 894.41–1788.81 mg COD/L*day, respectively, and increase as the HRT decreases from 6 to 4 days. The concentration of NH4+-N ranges from 278.67 to 369.46 mg/L, which is not in the range that disturbs the performance and stability of the hydrolytic acidogenic reactor. It was concluded that an HRT of 3 days and an ORL of 1788.81 mg COD/L*day were selected as optimal operating conditions for the high performance and stability of the two-phase anaerobic digestion of slaughterhouse wastewater in the hydrolytic–acidogenic reactor at a mesophilic temperature. The findings of this study can be applicable for other agro-process industry wastewater types with similar characteristics and biowaste for value addition and sustainable biowaste management and safe discharge.


Abstract If we take for granted that introspection is indispensable for the study of conscious mental states, the question arises what criteria have to be met in order for introspective reports to qualify as scientific evidence. There have been some attempts to argue (implicitly or explicitly) that it is possible to provide a satisfactory answer to this question while remaining agnostic with respect to questions about the nature of consciousness. Focusing on the aim of using introspection in order to generate phenomenological descriptions of conscious mental states, this paper argues that such an agnostic stance cannot be maintained, because the very meaning of "introspection" remains fuzzy as long as we don't have a clear understanding of how the mind does it. I show that current debates revolve around some of the same issues that were already in the background of debates around 1900, and I argue that a satisfactory treatment of introspection as a method cannot be separated from the aim of providing a satisfactory treatment of introspection as a feature of consciousness.


The COVID-19 pandemic and resulting high number of individuals requiring hospitalization has caused health care systems worldwide to alter hospital policies and procedures. This study examined how changes in hospital operations between March 2020 and March 2021 affected physiotherapists' roles and responsibilities in Ontario, Canada. Between February and March 2021, we conducted a cross-sectional study using an online survey of physiotherapists employed in acute care and rehabilitation hospitals. Among 230 respondents, 82 (35.7%) reported being redeployed at some point during the study period to new settings or areas of practice. Physiotherapists typically working in outpatient settings were the most likely to be redeployed (63.3%), with 62.9% of respondents reporting caring for COVID-19 patients. Among 37.1% of respondents reporting undertaking new responsibilities (e.g., personal support work, nursing, infection control), 72.0% reported being confident in their abilities; however, only 49.4% felt adequately trained. Hospital-based physiotherapists in Ontario, Canada took on a variety of traditional and non-traditional responsibilities during the first year of the pandemic. Although confident in their abilities, feelings of being inadequately trained highlight the need for improved processes when taking on new responsibilities to support delivery of patient care and physiotherapists' well-being.


Some new monoand bis(cyclopentadienyl)hafnium(IV) derivatives of dithiocarbamate ligands. in which one heterocycl ic ring (th iadiazole) is attached to nit rogen, have been prepared by the reactions of bis(cyclopentadienyl)hafnium(IV) chloride with potassium salts of dithiocarbamic ac ids in I : I and 1:2 molar rat ios. respectively, in refluxing tetrahydrofuran . The derivatives of types (C:;HshHfCI(DTC) and (C:;Hs)HfCI(DTCh have been characterized by elemental analysis, conductivity measurements and spectral (IR, IH NMR) st udies. All the complexes are monomeric and non-electrolyte in nature. IR and NMR spectral data of these complexes show the bidentate behaviour o f li gands and five-coordinate and six-coord inate structures fo r bis( cyclopentad ieny l )hafni um(I V) and mono( cyc lopentadieny l)hafnium(IV) derivatives, respectively.


The study concerned anti-inflammatory activity of a new tryptamine derivative - tryptamide. This preparation was effective in nonspecific inflammations and those involving immune mechanisms. Only postadjuvant inflammation appeared resistant to its effect. Its particular effectiveness was noted in the experimentally-induced iridocyclitis. Only in few tests, tryptamide was more effective than the reference drug phenylbutazone; in some cases the effect of both drugs was similar, but in the majority of cases tryptamide proved less effective.


Since the late 20th century, the world has been witnessing the rise of three major global forces with different kinds of power, effect and implications. The ® rst is the Westernisation of almost every aspect on the global scale: culture, economic and political systems, a market economy, free trade, education, technology, consumerism, language, entertainment, media, human rights and liberal democracy. Its power and effect resides in econocentrism founded on the `̀ secular mind'' 1 and modernity, which is manifested by economic rationality, progressive spirituality and modernisation faith. Today, it is believed that the world has entered the ultimate age of modernity. As Anthony Giddens observes, `̀ rather than entering a period of post-modernism, we are moving into one in which the consequences of modernity are becoming more radicalized and universalized than before'' . The second is the worldwide spread of radical Islamism, whose cultural image has been seen as violent, backward, insular, anti-secular, and anti-modern. Its power and effect reside in religious spirituality and ideological logocentrism. Islamism is expanding dramatically and is portrayed as a new post-Cold War threat to the West. With global believers numbering 1.2 billion, Muslims represent between 19.2% and 22% of the world's population. It has become the second largest religion in the world (Christianity has slightly less than 30%). Islam is growing at about 2.9% per year, which is faster than the total world population, which increases at about 2.3% annually. There are now 20 million Muslims in Europe, eight million of whom are in Western Europe. There are now over 1,000 mosques and Islamic centres in the United States, where there are six million American Muslims, and the number is still rising. Like most social-political movements, the expansion of Islamism takes different forms in different countries and its consequences are graver in some places than in others. But the true sense of threat in the West is becoming real enough, especially after the `̀ 9.11'' event.


The insufficiency of traditional GIS is discussed, the necessity of integrating the research of GIS with pervasive computing is studied,and main research contents of pervasive GIS are discussed.


The yeast Y′ element is a highly polymorphic repetitive sequence present in the subtelomeric regions of many yeast telomeres. The Y′ element is classed as either Y′-L or Y′-S, depending on its length. It has been reported that survivors arising from telomerase-deficient yeast mutants compensate for telomere loss by the amplification of Y′ elements. The totalSaccharomyces cerevisiae genome DNA data base was searched for Y′ elements, and 11 Y′-Ls and eight Y′-Ss were identified. As reported previously, many of the sequences were found to contain long open reading frames which potentially encode helicase. We examined the expression of the Y′ elements in telomerase-deficient Δtlc1survivors, in which the TLC1 gene encoding the yeast telomerase template RNA had been disrupted, and found that the Y′ element is highly expressed in the survivors, but not in the wild-type cells. Moreover, we demonstrated that the survivors produce a Y′-encoded protein designated as Y′-Help1 (Y′-helicase protein 1), and that this protein possesses helicase activity. Therefore, we suggest that the Y′ element has a novel and potentially important role in trans, in addition to the well characterized role in cis, in telomerase-independent telomere maintenance in yeast.


Abstract Energy markets are changing because of (1) the addition of nondispatchable wind and solar electric generating capacity and (2) the goal of a low-carbon energy system. The large-scale addition of wind and solar photovoltaics results in low wholesale electricity prices at times of high wind and solar output and high prices at times of low wind and solar input. The goal of a low-carbon energy system requires a replacement energy production system with assured peak energy production capacity. To minimize costs, capital-intensive nuclear reactors should operate at base load. To maximize revenue (minimize sales at times of low prices and maximize sales at times of high prices), the power cycle should provide variable heat and electricity. This requires the power cycle to (1) include heat storage that enables peak heat and electricity output that may be several times base-load reactor output and (2) provide assured peak power production. Assured peak power production requires the capability to efficiently burn low-carbon fuels such as hydrogen and biofuels. Alternatively, nuclear systems with base-load reactors can be built to produce peak electricity and storable hydrogen for industry, biofuels, and other markets. All power reactors with appropriate system designs can meet these requirements. The lowest-cost technologies for heat storage, assured peak power production, and hydrogen production require high-temperature heat. This economically favors salt-cooled reactors with the average temperature of delivered heat of about 650°C versus heat delivered at lower average temperatures from other reactors such as light water reactors: 280°C, sodium-cooled reactors: 500°C, and high-temperature helium-cooled reactors: 550°C. Salt-cooled reactors include (1) Fluoride-salt-cooled High-temperature Reactors (FHRs) with solid fuel and clean salt, (2) Molten Salt Reactors (MSRs) with fuel dissolved in the salt, and (3) fusion reactors with salt blankets. Future energy markets, nuclear systems (heat storage, assured peak energy production capacity, and hydrogen production) designed for such markets and the power cycle technologies that economically favor salt reactors are described.


The present research project consists in the implementation of recreational spaces with the reuse of used tires in the municipality of Girardot in the department of Cundinamarca, with this it is intended to contribute to the reduction of pollution that occurs due to the improper handling of tires in disuse.
The research was conducted based on descriptive and exploratory methodology, obtaining information from various sources such as observation, surveys, talks, and review of various work on the management that has been given to the disused tires at the local level, National and international. The project intervenes in the management of disused tires at the local level, carrying out a characterization of the sites to be improved, after this there is scope with the establishments that provide the service of maintenance and repair of automotive vehicles and with users of vehicles / cars and motorcycles. Resulting in the adaptation of three (3) playgrounds in the City. Focused on fulfilling the mission of the Civil Engineer of Uniminuto, with the results obtained, social and environmental solutions are given to the basic needs of the population, to transform their environment and resources through research.It is recommended to continue with additional research to identify alternatives that offer practical solutions for the use of solid waste generated in various activities.


Background and Objectives: Supporting self-management is now a vital element of care in chronic psychiatric and medical conditions. The Flinders Program of Chronic Condition Management, developed in the Department of Psychiatry at Flinders University, is now being used in Asian and western countries and has shown effectiveness in increasing self-management in chronic conditions and co-morbidities, including mental health conditions and medical illnesses. However, even proven self-management interventions are ineffective if barriers, either in the patient's own circumstances or in the health service, prevent selfmanagement. Identifying and quantifying these barriers is an important first step in reducing their impact. We conducted a systematic review of empirical research on factors obstructing patient self-management in chronic illness.


The (cid:415) provides a compara (cid:415) legal analysis of the responsibility for the disclosure of state secrets in it occupies a special place and is under close a (cid:425) en (cid:415) on of the state. It was found that the legisla (cid:415) on of the three studied states (USA, UK, Germany, fi rst of all divides the informa (cid:415) on into three blocks, and according to the degree of con fi den (cid:415) ality of informa (cid:415) on, measures and the degree of protec (cid:415) on of informa (cid:415) on are determined. It is concluded that a promising way to protect state secrets and dis (cid:415) nguish it from classi fi ed informa (cid:415) on will be to adopt the experience of three separate blocks of informa (cid:415) on, namely: especially classi fi ed informa (cid:415) on, the disclosure of which provides the highest level of punishment, classi fi ed informa (cid:415) on, responsibility for which should also be expressed and enshrining in the Criminal Code of Ukraine and con fi den (cid:415) al informa (cid:415) on, for the disclosure of which to establish administra (cid:415) ve liability,


After ending the Radar Antenna modification on the airborne plane, the initial installation error is need to be measured and to be compensated with the initial error. For the attitude measuring requirements of airborne radar Antenna mounted, This paper studies a non-contact optical measuring method based on the total station(a laser measurement equipment), which can solve the high precise attitude measuring problem. At first multiple points on the surface of Radar target and plane axis are measured, transform the corrdinate of Radar to the plane corrdinate to make the points fitting to the plane, then the points of Radar target are fitted to a plane;the attitude are obtained though the calculation and analysis from the fitting plane and the specified line,The principle ,scheme,calculating method and error analysis for airborne Radar antenna, have been detailed in the following papers. The measurement and algorithm method have been widely used in attitude measurement of weapons mounted, which are good to apply in the measurement; which can be applied in the other weapons target mounted on the airborne.


We describe a general way how to calculate optical forces and torque acting on colloids placed into laser interference field. In this paper we focus on a configuration with three interfering beams laying in one plane and we present a comprehensive analysis of trap properties and particle behaviour. We found that this arrangement can be used for sorting of particles according to their size or refractive index.


The use of ekphrasis has a long history in Western literature. The term at once calls to mind the shield descriptions in the Iliad and Aeneid and the description of Dido's Trojan War wall painting in the latter. These exemplify a tradition which has had a strong influence on succeeding writers, including Chaucer. His work has a number of ekphrastic passages, and for the most part they follow the classical tradition in the ways they use words to depict fictional works of art. Chaucer's use of ekphrasis in the House of Fame, however, is radically divergent from the traditional uses of the trope and from Chaucer's other ekphrastic passages in the way that it at times seems to abandon the role of mediator between the work of art and the reader for more direct communication, as though the wall were speaking instead of picturing. This unusual treatment of a traditional trope offers a comment on the nature of words and images, demonstrating the instability of their forms, and this concept resonates with a general theme of metamorphosis throughout the House of Fame.


Abstract A new method for the in situ generation of nitrile oxides is reported. The reaction conditions are mild and neutral.


The performance of a vector processor accessing vectors is strongly dependent on the conflicts produced in the memory subsystem. The concurrent memory access of several vector streams causes inter-conflicts between the references of different vectors. In a complex memory system (several memory modules are mapped in every bus) the number of conflicts increases because the bus must be shared by the vector streams. This paper proposes a method that allows a concurrent access to several vector streams reducing the average memory access time in vector processors with complex memory systems.<<ETX>>


Purpose: Using the Ohlson model of value relevance (1995), we examine the incremental effects of the environmental, social, and governance (ESG) rating on accounting information regarding R&D expenditure.
Design/methodology/approach: Samples are 3,449 firm-years of Korean manufacturing firms listed on the Korean Stock Exchange (KSE) for 2012~2021 years. We proxy the ESG activities by their ESG rating announced by the Korea Corporate Governance Service (KCGS). Our testing model is reconstructed from Ohlson's (1995) model with accounting expenses to test whether ESG rating plays an additional role in increasing the value relevance of R&D expenses.
Findings: Results show that higher ESG ratings increase the value relevance of development costs, but not research costs. The results are robust, with alternative fixed effect or double clustering, and are more relevant to those in low-technology industries or Korean non-chaebol companies. Further analyses reveal the effects of individual ESG activities that environment (E) and governance (G) increase the value relevance of capitalized development costs, but activities related to society (S) decrease value relevance. Additional test shows that voluntary disclosure additionally increases the value relevance of development cost in accounting information.
Research limitations/implications: This study shows that development cost rather than research cost increases the value relevance of companies, but ESG increases the value relevance only in terms of development cost.
Originality/value: We firstly show the mediating role of ESG activities in increasing the value relevance of a firm through R&D expenditure separating R&D expenditure into research expense and development costs exclusively obtained from Korean public firms.


According to the situation of Windows Mobile system which does not support normal hook functions and can not be used to protect the registry of system,this paper proposes to build hook functions for the system APIs.Based on the API call process in Windows Mobile system,it builds hook function for the API which regarding to the operation of registry,and intercepts this API.Experimental results shows that it can protect the registry effectively by intercepting the relevant API and improve the system's security.


WHENEVER THE DOMINO THEORY is discussed, Thailand's precarious situation on the turbulent frontiers of Communist Asia inevitably comes under scrutiny. Some of those who are ready to cast Thailand in the role of the next "falling domino" do so from an imperfect knowledge of Thailand's long history of dangerous living. This country is familiar with predators from both East and West. When the first Thai kingdom was founded by Sri Intratit (circa 1240) in the northern city of Sukhothai, the Mongols had already started their conquest of China. By the time King Ram Kamhaeng had consolidated the Thai kingdom in 1290, Kublai Khan had launched his campaigns of conquest from Peking to the south. Mongol fleets and armies invaded Burma, North Vietnam, Champa (South Vietnam), and Java. The Great Khan also sent threatening messages to Cambodia and Japan, demanding submission to his suzerainty. Thailand, however, was neither invaded nor threatened. King Ram Kamhaeng (or his predecessor King Ban Muang) had already paid tribute to Peking and been accepted as a loyal ally. Thai tradition has it that King Ram Kamhaeng himself journeyed twice to the court of Kublai Khan; but this is not supported by the Chinese chronicles. What is historically certain is that Thailand not only remained inviolate, but took advantage of the Mongol attacks on its neighbors to widen its own territories. Parts of Burma and Cambodia were annexed to the Sukho-


Summary This article describes the use of the ICF, the Inter national Classification of Functioning, Disability a nd Health, in rehabilitation and physiotherapy and the way the ICF can help to select proper assessment instruments for patient s during the rehabilitation process. The ICF is a classification develope d by the WHO to describe the functioning of a clien t. The ICF can be used to classify very relevant data in the process and outcome of rehabilitation care and physical the rapy, such as the findings of the patient, the findings of the therapist, the functional diagnosis (the outcome of the diagn ostic process), the treatment goals and the treatment results. Assessment in struments are tools to measure characteristics of t he person or the environment, which are relevant in the process of rehab ilitation or physiotherapy practice. These assessme nts can be tests, observation instruments and questionnaires and can be us ed as diagnostic and prognostic test and as outcome and evaluation measurements. In the selection of one or more instr uments for an individual patient, there are several steps the professional has to take: 1) know the purpose(s) of using an ins trument; 2) select the clinical variables you are i nterested in; 3) find the instruments that measure the chosen clinical variab les; 4) determine the applicability, availability a nd feasibility of the instrument; 5) know the psychometric characteristics of the chosen instruments; 6) select the instrument s that seem adequate; and 7) implement, use and evaluate the instruments. These steps are described.


To provide a comprehensive understanding of the competitive psychological climate, this research developed and validated the Competitive Psychological Climate Scale (CPCS) in China through three studies. In Study 1 ( N = 293), a large pool of items were developed and exploratory factor analysis was conducted, resulting in three 4-item scales representing competition of performance, competition of Guanxi with superior, and competition inspired by coworkers. In Study 2 ( N = 291), confirmatory factor analysis demonstrated that a three-factor model offered the strongest fit to the data. Configural, metric, and scalar invariance were achieved. Moreover, concurrent validity, convergent, discriminant validity was preliminarily evidenced. In Study 3 ( N = 411), results from the two-wave data evidenced predictive validity by demonstrating that the three dimensions of the CPCS had unique and significant impacts in predicting silence and career satisfaction through emotional exhaustion. The development of CPCS provides a useful tool for researchers and practitioners to understand the mixed effects of competitive psychological climate.


This article presents several ways of managing input data from different perspectives and the possibilities to use them on several interpolation methods and calibration techniques applied to a given data set. These techniques have been applied in order to obtain a better estimate of the temperature in a given geographical area. In order to determine the most accurate result, several analyses have been conducted on the identification of the temperature with the least deviation rate. As ways of measurement, several weather stations were first taken into consideration, whereupon this number increased exponentially, and eventually, calculations were made with the sole purpose of finding the minimum cumulative deviations from a certain point. By looking at the results, it follows that at least one of these data management methods, which constitutes a perspective in itself, can be used as a means to improve its appliance to methods of estimating linear weight, techniques and more. Moreover, in the technological era, an automatic selection for taking in reception the best value from the applied perspectives was developed and implemented. This selection offers a better disclosure for the most coherent information, template revealing and comparison to the latest results.


: The anostracan Artemia is one of the few organisms that can inhabit hypersaline lakes. In Argentina, this genus is represented by two species: the invasive A. franciscana Kellogg, 1906 and the autochthonous A. persimilis Piccinelli & Prosdocimi, 1968, the latter being the only one recorded in the province of La Pampa. Some of the biological aspects of A. persimilis are known based on laboratory studies, and data on its ecology in natural conditions are scarce. The aim of this work is to present information on the density, biomass, and population structure of A. persimilis in relation to environmental variables in Utracán, a hypersaline lake of the semiarid Central Pampa of Argentina. Water and zooplankton samples were taken monthly from May 2009 until August 2010. The mean density and biomass were 56.98 ind.L -1 (± 106.64) and 1.23 mg.L -1 (± 1.35), respectively. The species was negatively affected by salinity, and it was absent between November and February, when salinity exceeded 320 g.L -1 . However, when it was present, even during the months of higher salinity, a high proportion of naupliar stages was found, which could indicate that, in nature, A. persimilis can reproduce with high salinity. Although it has been indicated that A. persimilis could be displaced by A. franciscana , the highest tolerance of the former at low temperatures, which allowed the population to continue reproducing at values close to 3°C, would limit its displacement. However, an increase in the temperature of lakes as a result of global warming could modify this situation and allow the advance of the introduced species to the south.


The effects of light,temperature,food,starvation and destruction of auricle on Dugesia japonica feeding behaviors were studied. The result showed that weak light and low temperature were suitable for Dugesia japonica feeding.Cooked egg yolk was the most favourable food to Dugesia japonica among four kinds of man-made food.There was positive correlation between starvation time and feeding speed in some degree.Dugesia japonica with its auricle destroyed lost its feeding ability.The function of brain on feeding is still unclear.


Chiral cosmic string loop tends to the stationary (vorton) configuration due to the energy loss into the gravitational and electromagnetic radiation. We describe the asymptotic behaviour of near stationary chiral loops and their fading to vortons. General limits on the gravitational and electromagnetic energy losses by near stationary chiral loops are found. For these loops we estimate the oscillation damping time. We present solvable examples of gravitational radiation energy loss by some chiral loop configurations. The analytical dependence of string energy with time is found in the case of the chiral ring with small amplitude radial oscillations.


Korea-Yanbian reserve sports talents cultivation, including coaches, trainees and their parents has been investigated by questioning, interviewing and referring to literature. It has found that the major (problem) are the low-qualified coaches, the unreasonable events distribution, the conflict between training and studying and the unsteady feature of the trainees. Therefore, improvement of the coaches' level, arrangement of the events system scientifically, reform of the cultivation (system) and combination of athletic sports and school sports have become completely urgent.


The idea of the project is to trace the robot position and orientation and precise it by the implementation of the advanced algorithms based on triangulation and trilateration methods. Precise navigation is a difficult task since the odometry sensors used in this context are subject to systema


Purpose: Operation theatre management has always been a challenging aspect for any hospital administrator because it includes staff from various categories, a large amount of infrastructure, maintenance work, risk management, infection control priorities, and, most importantly, patient safety. Nurses play a crucial part in the healthcare team. Nursing work is demanding. Nurses work to prevent illness, promote health, and extend people's lives and the lives of the community. Nurses are involved in patient care, doctor care, and administrative care. Nurses' job satisfaction is crucial for healthcare institutions because it influences both the nursing care quality and patients' satisfaction.
Design/methodology/approach: The research approach adopted is a descriptive study approach.
Findings/Result: The individual's satisfaction levels can be influenced and shaped by various factors. Due to rising labor costs and the enormous shortage of nurses, satisfaction in the nursing job sector is a very important but also a crucial challenge for healthcare organizations. The key importance is the motivation of this discipline (Nurses) so that their involvement in the hospitals they work and practice their profession will be as satisfactory as possible. The aspects that affect a nurse's satisfaction with their work in operation theatres were identified to be appreciable salary with increment, duty time management, experienced staff as peers, reduced workload & stress, more leave privileges, teamwork, the advanced technology at work, in-service education & training, and more respect at their place of work, from the study as perceived by the operation theatre nurses' themselves.
Originality/value: Employee job satisfaction is the level at which an individual is content with a range of variety in their work, like the overall nature of their work. However, a person's needs and personality traits also have a role in their level of job satisfaction.
Paper Type: Case study


The present invention relates to a method for enhancing the efficacy of immune checkpoint inhibitors. Specifically, the present invention is a method for enhancing the efficacy of an immune checkpoint inhibitor administered to a subject as part of a treatment regimen, comprising combining a pharmaceutically effective amount of an SK1 inhibitor with the immune checkpoint inhibitor. And administering to a subject.


At oxidizing of liquid zinc by H2O/CO2 mixture at supercritical parameters it is found the formation of nanoparticles (ZnO)n with size from 1.5 to 100 nm and combustible substances: H2, CO, lower paraffin and aromatic hydrocarbons, alcohols and formaldehyde. Composition of combustible products depends on H2O/CO2 ratio in mixture. Synthesized ZnO samples were studied by methods of scanning and transmission electron microscopy, thermal analysis.


Liquid crystal director distributions have been numerically analyzed between asymmetric anchoring surfaces, that is, infinitely strong and very weak anchoring strength interfaces. In a hybrid aligned nematic (HAN) cell and a twisted nematic (TN) cell, HAN and TN orientations turn to a homogeneous orientation when the weak anchoring strength is lower than a critical one. Relationships between the anchoring strength and elastic constants of the liquid crystal were analyzed to be of a quasi-homogeneous orientation. The quasi-homogeneous orientation returned to the original HAN and TN orientations under voltage application. Low-driving electro-optical properties with no threshold voltage can be obtained in a quasi-homogeneous HAN cell. A unique voltage–transmission curve of 0–100–0% appeared in a quasi-homogeneous TN cell between the crossed polarizers.


This paper investigates the problem of optimal partitioning of a measurable space among a finite number of individuals. We demonstrate the sufficient conditions for the existence of weakly Pareto optimal partitions and for the equivalence between weak Pareto optimality and Pareto optimality. We demonstrate that every weakly Pareto optimal partition is a solution to the problem of maximizing a weighted sum of individual utilities. We also provide sufficient conditions for the existence of core partitions with non-transferable and transferable utility.


Objective: To observe the influence of XiaoZhong ZhiTong mixture on rats with acute spinal cord injury.Method: Rat models with T8~T9 spinal cord injury were established with XU Shao-ting′s method of hemi-sectioned spinal cord injury.60 rats were randomized into blank group(A),group of XiaoZhong ZhiTong mixture low-dose,medium-dose,high-dose(B,C,D),methylprednisolone group(E) and model group(F) on average based on gender and physique of the rats.Group of B,C,and D were administered with XiaoZhong ZhiTong mixture of 1/20,1/10 and 1/5 of adult equivalent dosage,three times per day,then changed to twice per day at the eighth day after the operation;E group were given with intramuscular injection of methylprednisolone(30 mg/kg).Groups of A and F were given by same amounts of saline.After administration for 14 days,the contents of serum IL-6 and NOS were detected with radioimmunoassay;the expression of Capase-3 was detected with immunohistochemical method.Pathological changes of injured spinal tissues,stained with HE staining,in different groups were observed.Result: HE staining suggested that the improvement of injured spinal cord tissue in D group was superior to that in C group and similar to E group;The contents of IL-6 and NOS in injured spinal cord tissue in F group significantly raised,D and C group compared with E group showed significant difference(P0.01).The expression of Caspase-3 in F group raised,there was statistical meaning of the expression of Caspase-3 in C group compared with E group and D group(P0.01).Conclusion: XiaoZhong ZhiTong mixture can lower the level of IL-6 and NOS in the injured spinal cord tissue and inhibit the expression of caspase-3 after acute spinal cord injury.


Aiming at the situation and existing problems of 35 kV power grid communication,based on many of the characteristics and advantages of the OPtical fiber composition Phase Conductor(OPPC),puts forward the new type of communication transmission schemes by OPPC,solves the problems of automation,dispatch and communication of 35 kV power grid,improves the quality and quantity of communication transmission.


2018;13(1-2):59. Ballon aortic valvuloplasty (BAV) was introduced more than three decades as an alternative to replacement of aortic valve in older patients who are considered unsuitable for surgery.1 Because of the high rate of early restenosis and without affecting long-term survival, the development of the procedure has stopped. However, with recent technological advances, especially with the appearance of a TAVI, there was a revival of this technique. Balloon aortic valvuloplasty is a percutaneous therapeutic option for patients with severe aortic stenosis but the effectiveness of this procedure depends on the morphology of the stenotic aortic valve and the respective dilation mechanism. In younger patients with congenital aortic stenosis, there are good acute and mid-term results.


Cell (1) fuel cell, electrolyser or accumulator, comprising: a anode (3), -a cathode (4), characterized in that it comprises, between the cathode and the anode, a layer (2) of a material comprising boron nitride activated, the nitride layer comprising boron powder contained in a polymer matrix.


In recent scholarship the emergence of belief in the resurrection of the body in the writings of the early Church has been linked to the experience of martyrdom and persecution. By contrast, this article seeks to treat the resurrection of martyrs in the writings of the apologists as part of a broader philosophically informed conversation about identity and change. Rather than seeing the writings of the apologists as contingent theology, it argues that writers like Tertullian and Athenagoras use the resurrection of the martyrs both to address anxieties about the persistence of identity, and to highlight the ethical importance of the functionality of the body.


The toughening modification of epoxy resin by polyurethane prepolymer (PU) can effectively solve the disadvantage of high brittleness in its application. In this study, a convenient way to toughen epoxy resins was explored, and the monomers PPG and MDI for the synthesis of polyurethane prepolymers were used for a one-step modification of epoxy resins. The test results of viscosity and elongation at break showed that P-M reduced the viscosity of the epoxy resin and improved the toughness. Especially when the content of P-M was 25%, the elongation at the break of the modified EP reached 196.56%. From a thermogravimetric and pyrolysis kinetic analysis, the P-M modification had better thermal stability than the PU modification. These findings have particular implications for the toughening and engineering applications of epoxy resins.


This study investigated the socio-economic determinants at the individual and contextual level of household poverty in Indonesia. The data used in this study is drawn from the March 2020 Indonesia-National Socio-Economic Survey (Susenas) provided by BPS, Statistics-Indonesia. The data were analyzed using the Multilevel Logistics Regression Model. This study indicates that the achievement of the Human Development Index at the provincial level affects the reduction of the poor at the household level. Moreover, at the individual level, household size, education level, and employment status of the household head significantly affect household poverty. The results of this study underscore the need to look beyond the influence of individual-level factors in addressing regional variations in household poverty in Indonesia. Therefore, Government policies to increase human development in provinces with low HDI are needed.


In the previous essay of this series, we considered the fossil record as one piece of evidence in support of the theory of evolution. Here, we will discuss three additional threads of the web of evidence for evolution taken from organismal biology, from molecular biology, and from biogeography. Organismal Biology: If evolutionary theory is true, then organisms should bear marks of their evolutionary history within their bodies. Biologists point to so-called vestigial organs as one of these marks. Vestigial organs are organs or structures in a living species that have apparently lost most or all of the function associated with their ancestral species. Their existence is best explained by the evolutionary history of the living species. For example, whales and dolphins have a rudimentary pelvis or hipbone. Snakes and legless lizards have rudimentary pelvic bones as well. Why would these animals that lack limbs have a hipbone? Strikingly, whale, dolphin, snake, and legless lizard embryos initially develop embryonic hind legs or limb buds though these are reabsorbed by the developing organism before birth or hatching. Why do these animals have these transient rear limbs during their development? The best explanation is that these creatures evolved from an ancestor shared in common with four-limbed animals, and that the vestigial hipbone and their vestigial embryonic limbs are marks of that evolutionary history. In the human species, it is striking that the embryo initially develops a tail during his development in his mother's womb. At between four and five weeks of age, the human embryo has a dozen or so developing tail vertebrae which extend beyond his anus and his legs, accounting for more than 10% of the length of his body. By the ninth week of pregnancy, however, most of this extensive embryonic tail has undergone regression by a mechanism of programmed cell death. Why do we have these transient embryonic tails? Once again, the best explanation is that we evolved from a primate ancestor that had a tail and that we retain a rudimentary genetic program for making tails. Incidentally, this would also explain those rare human beings who are born with an actual tail, which can be as long as 5 inches and which can move and contract. Here the normally silenced tail-making genetic program is reactivated and a rudimentary tail is made. Molecular Biology: In recent years, biologists have been able to decode the information found in the DNA of numerous species of life—called


Evolutionary Computation Methods (ECMs) are proposed as stochastic search methods to solve complex optimization problems where classical optimization methods are not suitable. Most of the proposed ECMs aim to find the global optimum for a given function. However, from a practical point of view, in engineering, finding the global optimum may not always be useful, since it may represent solutions that are not physically, mechanically or even structurally realizable. Commonly, the evolutionary operators of ECMs are not designed to efficiently register multiple optima by executing them a single run. Under such circumstances, there is a need to incorporate certain mechanisms to allow ECMs to maintain and register multiple optima at each generation executed in a single run. On the other hand, the concept of dominance found in animal behavior indicates the level of social interaction among two animals in terms of aggressiveness. Such aggressiveness keeps two or more individuals as distant as possible from one another, where the most dominant individual prevails as the other withdraws. In this paper, the concept of dominance is computationally abstracted in terms of a data structure called "competitive memory" to incorporate multimodal capabilities into the evolutionary operators of the recently proposed Cluster-Chaotic-Optimization (CCO). Under CCO, the competitive memory is implemented as a memory mechanism to efficiently register and maintain all possible optimal values within a single execution of the algorithm. The performance of the proposed method is numerically compared against several multimodal schemes over a set of benchmark functions. The experimental study suggests that the proposed approach outperforms its competitors in terms of robustness, quality, and precision.


This investigation represents the fabrication of novel composites having the biopolymer chitosan with Ag doped hydroxyapatite (HAP)-magnetite nanoparticles (Fe3O4 NPs). In this study, Ag doped HAP was synthesized by a sol–gel method using different silver concentrations such as 1%, 3% and 5%. Furthermore, Fe3O4 NPs were prepared by a co-precipitation technique and the composite was developed with Ag doped HAP. The fabricated Ag:HAP–Fe3O4 composites were incorporated into the chitosan matrix by a planetary ball milling technique and were tested for their reliability as a promising biomaterial for orthopaedic applications. The present study aims to evaluate the in vitro hemocompatibility of Ag doped HAP–Fe3O4 incorporated chitosan composites using a hemolytic assay at the concentrations of 200, 400, 600, 800 and 1000 μg ml−1. The results have shown that the developed composites exhibit a hemolytic ratio of less than 5%, which proved them as good blood compatibles in nature. The antibacterial activity of the composites was evaluated in Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria, which determined that the composites can extensively inhibit the active growth of microorganisms. In addition to this, in vitro bioactivity behavior was performed in SBF solution for 7 days in order to analyze carbonated apatite formation on the surfaces of the composites and they were found to have characteristic bone bonding ability. The in vitro biocompatibility of the fabricated nanocomposite (C-3) was examined by MTT assay using NIH-3T3 fibroblast cells for incubation periods of 24 and 48 h, and the exposed concentrations are similar to the hemolytic assay. This MTT assay indicates that the fibroblast cells were non-toxic up to the concentration of 400 μg ml−1 with prominent cell attachment and proliferation on C-3 composites. These prepared composite materials were further characterized by ATR-FTIR, powder-XRD and SEM-EDAX analysis. The research findings have shown that the hybrid composites of 5%@Ag:HAP–Fe3O4–chitosan can be widely used as a favorable material for orthopaedic and dental applications.


The study was conceptualized to compare profits of organic and non-organic farming technologies among smallholder fluted pumpkin farmers in Delta State, Nigeria. A multistage sampling technique was employed in the selection of location and respondents. The data were collected using structured questionnaire from 240 organic and non-organic smallholder fluted pumpkin farmers. Data obtained was analyzed using descriptive statistics and enterprise budgeting method. Results indicated that the profit realized by organic and non-organic (conventional system) fluted pumpkin farmers was N561,850 and N222,130 per farmer per plot, respectively. The study concluded that organic system of vegetable production was more profitable than conventional system. It was recommended that farmers should concentrate more on organic system of fluted pumpkin production to enable good profit.


The low knowledge of tax administration in one of the fast boat MSMEs has an impact on several things, including MSME compliance in paying taxes, the accuracy of tax calculations, and the timeliness of tax reporting. This study aims to analyze the effectiveness of tax training as measured by the indicators of reaction, learning, behaviors, organizational results, and cost effectiveness. The method used in this research is descriptive method with a qualitative approach, this research is a field research, involving sixteen (16) informants. Data collection techniques used include observation, interviews, documentation with data analysis techniques, data reduction, data presentation, drawing conclusions and data verification. The results of this study, the training method used is a case study in the form of technical guidance in order to solve real problems related to PPh in fast boat SMEs. Tax training for fast boat SMEs has been effective so that it is expected to contribute to increasing taxpayer compliance which has implications for state revenue.
Keywords: Effectiveness; Competency Improvement; MSME taxation; Tax Compliance


In an 802.11ac-based MU-MIMO network comprised of multiple cells1, inter-cell interference allows only a single AP to serve its clients at the same time, significantly limiting the network capacity. In this work, we overcome this limitation by letting the APs and clients in interfering cells coordinately cancel the inter-cell interference using their antennas for beamforming. To achieve such coordinated interference cancellation in a practical way, we propose a novel two-step optimization. First, without requiring any channel knowledge, each AP and client optimizes the use of its antennas for either data communication or inter-cell interference cancellation, in order to maximize the total number of deliverable streams in the MU-MIMO network. Second, with only partial channel knowledge, each AP and client optimizes their beamforming weights after the optimal antenna usage has been identified in the first step. Our solution, CoaCa, integrates this two-step optimization into 802.11ac with small modifications and negligible overhead, allowing each AP and client to locally perform the two-step optimization. Our experimental evaluation indicates that for a MU-MIMO network with two cells, by cancelling the inter-cell interference CoaCa can convert the majority of the expected number of streams increase (50%-67%) into network capacity improvement (41%-52%).


The process of extracting natural gas from gas hydrate‐bearing sediments (GHBS) may yield significant sand influx due to the metastable nature of GHBS. Selecting appropriate sand control media is vital to addressing the challenges caused by excessive sand production. This study proposes a protocol called holding coarse expelling fine particles (HCEFP) for sand control design. The protocol aims to provide a new optimization method for screen mesh size selection for clayey silt hydrate reservoirs. Detailed optimizing procedures of proper candidate screen mesh sizes in hydrate exploitation well in clayey silt hydrate reservoirs are depicted based on the HCEFP. Then, the site W18, which is located in the Shenhu area of the northern South China Sea, is taken as an example to illustrate the optimization procedure for screen mesh size selection. The results reveal that complete solid retention via a standalone screen is rarely beneficial as high clay contents can adversely affect wellbore productivity due to excessive plugging. Screen aperture size selection for clayey silt hydrate wells should strike a balance between retaining coarser particles and avoiding screen blockage by the relatively fine particles. Furthermore, longitudinal heterogeneity of the PSDs also increases the difficulties associated with sand control design. Multistage sand control optimization is necessary in hydrate production wells. For Site W18, we recommend that the entire production interval can be divided into two subintervals for multistage sand control operations.


The Eocene sediments of southern Maryland and adjacent Virginia have yielded multilocular fruits assignable to the extinct generaWetherellia Bowerbank andPalaeowetherellia Chandler. This is the first report of their co-occurrence in one deposit.Wetherellia has previously been reported from the Eocene of southern England and West Germany (two species), whilePalaeowetherellia has been reported from the Eocene and possibly latest Cretaceous of Egypt (one species). APalaeowetherellia-like fruit has been reported from the Eocene of southeastern North America.Wetherellia marylandica comb. nov. andPalaeowetherellia species are described; new information is provided for the previously established speciesWetherellia variabilis andW. dixonii. The familial assignment of both genera is reviewed.Palaeowetherellia is most similar to fruits of the tribe Hippomaneae of the Euphorbiaceae, whileWetherellia finds counterparts in the Euphorbiaceae and the Meliaceae. While the exact affinities ofWetherellia are difficult to resolve through comparison to modern fruits, the similarity ofWetherellia andPalaeowetherellia might suggest that the former is more likely euphorbiaceous than meliaceous. The discovery of these New World members of both genera reinforces the importance of floristic exchange across the North Atlantic in earliest Tertiary time.


Abstract Diagnostic critical phosphorus (P), which is the P concentration in tissue that was related to 90% of the maximum, P nonlimiting yield measured at the time of sampling, was determined for dried whole shoots and seed (grain) of oats (Avena sativa L.), barley (Hordeum vulgare L.), triticale (xTriticosecale L.), and narrow‐leaf lupins (Lupinus angustifolius L.). For all species, diagnostic critical P in dried whole shoots generally decreased with increasing plant age and was larger for grain than dried whole shoots near maturity. For dried whole shoots, diagnostic critical P ranges (%P, dry weight basis) [days from sowing (DAS)] were oats, 0.72 (30 DAS)–0.23 (105 DAS); barley, 1.09 (30 DAS)–0.24 (203 DAS); triticale, 1.2 (30 DAS)–0.11 (120 DAS); and lupin, 0.60 (66 DAS)–0.21 (163 DAS). For grain, mean diagnostic critical P (range) was oats, 0.27 (0.18–0.39); barley, 0.32 (0.23–0.35); triticale, 0.22 (0.19–0.25); and lupin, 0.31 (0.25–0.41). In addition, we related the P concentration in dried whole shoots to grain yield measured at the end of that growing season (prognostic critical P). For dried whole shoots of each of the four plant species, the decrease in both diagnostic and prognostic critical P concentration as the plants matured was very similar, so both procedures predicted similar grain yields at the end of that growing season.


TPS1134 Background: Multiple lines of evidence implicate the IL-6/JAK2/Stat3 signaling pathway in metastatic progression and therapeutic resistance in breast cancer (Marotta et al, JCI2011; Britschgi et al, Cancer Cell 2012). Ruxolitinib, an oral inhibitor of JAK1 and JAK2, is approved for the treatment of intermediate or high-risk myelofibrosis, but has not been extensively tested in solid tumors. Methods: Pts with triple-negative breast cancer or inflammatory breast cancer of any subtype are eligible for prescreening of archival tumor tissue for pStat3 expression by immunohistochemistry. Pts with high (Cohort A; T-score >5) or low (Cohort B; T-score 3-4) pStat3 expression, measurable disease, adequate organ function, ECOG PS 0-2, and progression through > 1 line of prior therapy may proceed to receive ruxolitinib, 25 mg orally twice daily. Staging studies are performed at baseline (BL) and every 8 weeks (wk). Baseline tumor biopsy is required for pts who have accessible disease, with an optional biopsy ...


An electronic device comprising a support plate (2), at least one electronic circuit chip (5) mounted on a front face (4) of the support plate before and, above this front face, an encapsulation block (7) wherein said chip is embedded and whose periphery has corners, device wherein the encapsulation block has, in at least one local area (11) located in at least one corner and from the front face of the wafer support, a reduced thickness relative to the thickness of the block at least in the surrounding area. A method of manufacturing wherein the reduced thickness region is obtained by molding or by machining.


In addition to being a small-town doctor who delivered more than 3,000 babies, William Carlos Williams was a deeply serious thinker considered on of the foremost poets of the century. In this remarkable, rich blend of art and scholarship, Paul Mariani unfolds Williams' life and times while simultaneously letting the reader inside the poet's mind and language. Photographs.


In this paper, we present an efficient alternative method for the evaluation of the three-photon transition matrix element in the dipole approximation from the ground state to bound states in atomic hydrogen. This method is a variation of the Dalgarno–Lewis method for the treatment of the second-order Stark effect in the hydrogen atom. In this approach, the infinite double sum over the complete set of states including the continuum states present in the third-order perturbation theory result is treated exactly. The closed analytical expression obtained for the matrix element, as a function of incident photon energy, clearly displays all singularities present in the original third-order perturbation theory result.


The investigation explores the influence of the induced magnetic field and variable mass diffusivity on an unsteady incompressible mixed convective double stratified and chemically reactive flow of Jeffrey fluid through a porous medium with heat, and mass flux boundary conditions. The system of flow field nonlinear partial differential equations is reduced into coupled nondimensional ordinary differential equations using appropriate similar variables, then worked out a numerical solution via shooting technique along with Rung‐Kutta fourth‐order scheme. The results are analyzed for various physical flows, heat and mass transfers, induced magnetic field, and skin friction against disparate prominent parameters via graphs and tables. It is recognized that the temperate of the fluid is enhanced with thermal stratification; however, the concentration of the fluid is decreased with magnetic Reynold's number. The comparison of numerical values of skin friction with the existing literature for limiting sense.


This study investigated the burrow morphology of the mud shrimp, 'Laomedia healyi' Yaldwyn and Wear, in stands of mangrove in Western Port Bay, Victoria. Burrow structure was described from resin casts. L. healyi burrows extended further horizontally than vertically and burrows were constructed around the pneumato-phores that densely penetrate the sediment at the base of the mangrove trees. Burrows had multiple surface openings, several of which were circular and constricted and others that were oval shaped, connected to a single vertical or sloping main tunnel. The tunnels had a sub-circular cross section with smooth floors and rough walls and roofs and tunnel diameters were considerably larger than the inhabitant. Bulbous terminal chambers were present but did not contain plant material. The characteristic features of L. healyi burrows indicate that the species is most likely a deposit feeder.


The neuronal microtubule cytoskeleton is key to establish axon-dendrite polarity. Dendrites are characterized by the presence of minus-end out microtubules, however the mechanisms that organize these microtubules minus-end out is still poorly understood. Here, we characterized the role of two microtubule minus-end related proteins in this process in Caenorhabditis elegans, the microtubule minus-end stabilizing protein CAMSAP (PTRN-1) and a NINEIN homologue (NOCA-2). We found that CAMSAP and NINEIN function in parallel to mediate microtubule organization in dendrites. During dendrite outgrowth, RAB-11 positive vesicles localized to the dendrite tip function as a microtubule organizing center (MTOC) to nucleate microtubules. In the absence of either CAMSAP or NINEIN, we observed a low penetrance MTOC vesicles mis-localization to the cell body, and a nearly fully penetrant phenotype in double mutant animals. This suggests that both proteins are important for localizing the MTOC vesicles to the growing dendrite tip to organize microtubules minus-end out. Whereas NINEIN localizes to the MTOC vesicles where it is important for the recruitment of the microtubule nucleator γ-tubulin, CAMSAP localizes around the MTOC vesicles and is co-translocated forward with the MTOC vesicles upon dendritic growth. Together, these results indicate that microtubule nucleation from the MTOC vesicles and microtubule stabilization are both important to localize the MTOC vesicles distally to organize dendritic microtubules minus-end out.


In the literature, much emphasis has been placed on the Kwakw a k a 'wakw winter ceremonial with its lore of cannibalism, the taming of a man gone wild, its intriguing dances, vibrant and intricately carved masks, its art, drama, and its interaction with the spirit world. Many of these writings attempt to re-interpret the Boas and Boas-Hunt materials in an effort to gain an understanding of the winter ceremonial's fundamental meaning. This article moves the discussion of the Kwakw a k a 'wakw ceremonial in a different direction. By considering the Kwakw a k a 'wakw summer ceremonial, its connection to salmon and traditional animistic beliefs, we begin to understand how Kwakw a k a 'wakw cosmology was sensitive to salmon ecology. I argue that Kwakw a k a 'wakw beliefs connected to the summer ceremonial not only promoted salmon stewardship but that it was upon this belief system and the corresponding practices that the success of the famous winter ceremonial relied.


Results of an investigation into the effect of the mutual position of the inlet and outlet connecting pipes on the characteristics of the gas turbine of an internal combustion chamber supercharging unit are considered. Experimental data are presented permitting evaluation of the economic efficiency of supercharging units depending on the design accepted.


The outdoor barbecue has come into our daily lives gradually. This paper focuses on the design of the outdoor barbecue and users' requirement in domestic market through the methods of the survey and the analysis, indicates that the design of the outdoor barbecue needs pay attention to the many issues, such as the shape, function, use and materials etc, and sets the direction for the design of the outdoor barbecue in the future.


Background Women with a history of mainly severe and early onset preeclampsia have an increased risk of future cardiovascular disease. During these complicated pregnancies increased levels of anti-angiogenic factors can be found. We hypothesize that women with a history of severe very early onset preeclampsia still have increased levels of these biomarkers years after this pregnancy, resulting in increased risk for cardiovascular disease. Methods Twenty women with severe early onset preeclampsia before 24 weeks' gestation, who delivered between 1993–2003 in a tertiary referral centre and twenty matched controls with uncomplicated pregnancies and healthy term infants, were addressed for participation in the study. Venous plasma samples were analyzed for basic fibroblast growth factor (bFGF), placental growth factor (PLGF), soluble fms-like tyrosine kinase-1 (sFlt-1), vascular endothelial growth factor (VEGF), E- and P-selectin, soluble intercellular adhesion molecule-3 (sICAM-3) and thrombomodulin by ELISA. Results Sixteen case subjects and 18 control subjects consented participation. The median time interval index pregnancy to study was 9.4 and 9.7 years for cases and controls, respectively. Median levels for cases-controls (p-value) were not different; bFGF: 17.43–11.11 pg/mL (0.33), sFlt-1: 102.98–101.92 pg/ml (0.84), PLGF: 3.57–4.20 pg/mL (0.38), VEGF: 64.05–45.72 pg/mL (0.73), E-selectin: 5.11–4.68 ng/mL (0.20), P-selectin: 85.35–71.69 ng/mL (0.69), sICAM-3: 0.42–0.63 ng/mL (0.41) and Thrombomodulin: 0.92–0.93 ng/mL (0.59). Conclusion There were no differences in angiogenic biomarkers between women with a history of severe early onset preeclampsia versus uncomplicated pregnancy almost 10 years later, suggesting that these angiogenic factors will not contribute to the early detection of women at risk for future cardiovascular disease.


Three years ago I was appointed to St Kevin's College as a secondary mathematics teacher and Gifted and Talented Coordinator. This paper examines how I made the mathematics program for upper primary and lower secondary levels based on Problem Solving and presents some findings after thirty-six months of trialling.


A stabilized fiber laser is presented for low frequency, sensing applications. Suppression of noise to 15 fε/Abstract: Hz (2 Hz/Abstract: Hz) is demonstrated at 60 Hz. For a 20 mm sensor, displacement sensitivity of 0.3 fm/vHz is expected.


An object of the present invention to provide an electron emission efficiency and is excellent in life with improved electron-emitting material, an electron emission display device and a method of manufacturing the same having the same. In the present invention, to this end, provides a hydrogen atom bonded to the electron-emitting material surface, the front panel having a phosphor layer; The electron-emitting device that is joined with the front panel to form a predetermined space; And it provides an electron emission display device and a method of manufacturing the same comprising a hydrogen emitter disposed inside of the space formed with the front panel and the electron-emitting device.


It plays a key role in real-time efficiency of PLC online debug that the address of monitored variable is invariant.A method of automatic generation of address dynamically to map is proposed.It can allocate continuous memory through debug table and minimize communication time.The experimental results show that the debug speed and efficiency is improved largely.


Described are compounds of formula (I) where the symbols and indices have the meanings given in the description. These are suitable for controlling pests.