2018) Myocardial Infarction with Angiographically Normal Coronary Arteries in Young People, About One Case: Role of Cardiac Magnetic Resonance Imaging. J Card Disord Therapy 1: 202


SUMMARY Pentazocine and pethidine have been compared in the dose ratio 45:75 for their depression of respiration in normal subjects. The respective additive actions of the two drugs were investigated by comparing the effects of a single dose with those of two repeated half—doses. Some degree of ventilatory depression was found consistently. A first half-dose of pentazocine 22.5 mg had a greater effect than a first half—dose of pethidine 37.5 mg, but a second half-dose of pentazocine had a smaller additive effect. The results support existing evidence that a "ceiling" for respiratory depression is attained at a relatively low dosage of pentazocine.


This paper addresses the problem of predicting emergent leaders (ELs) in small groups, that is, meetings. This is a long-lasting research problem for social and organizational psychology and a relevant problem that recently gained momentum in social computing. Toward this goal, we propose a novel method, which analyzes the temporal dependencies of the audio-visual data by applying unsupervised deep learning generative models (feature learning). To the best of our knowledge, this is the first attempt that sequential data processing is performed for EL detection. Feature learning results in a single feature vector per a given time interval and all feature vectors representing a participant are aggregated using novel fusion techniques. Finally, the EL detection is performed using the state-of-the-art single and multiple kernel learning algorithms. The proposed method shows (significantly) improved results compared to the state-of-the-art methods and it can be adapted to analyze various small group interactions given that it is a general approach.


The first images of Jupiter's north pole show storm systems and weather activity unlike anything previously seen in the solar system's other gas giants.


The article reveals the psychological specificity of the organization's culture from the perspective of its perception of corruption. Anti-corruption culture is presented in the context of human relations through the prism of moral and immoral, proper and improper, good and evil, useful and harmful, legal and illegal, beautiful and ugly. It is noted that the anti-corruption culture, as opposed to the corruption culture, is studied as certain value guidelines aimed at the manifestation of an active citizen's position regarding corruption. We consider anti-corruption culture as a person's ability to consciously and morally resist corruption. Also, if you rely on the theory of contagion, you can imagine a model of the formation of a corruption subculture, where the value of one individual becomes the value of the group. The spread of both corrupt and other values within the group occurs as a result of the exchange of cultural samples through speech, behavior, clothing, and experience. Such an exchange continues unconsciously in the process of gaining experience and improving professional skills. The mechanisms by which the corruption subculture survives have been determined. The stages of its development in the organization are presented. It was noted that the main difference in the formation of the organizational anti-corruption culture is its development at the level of the philosophy and ideology of the organization, in strict control, as well as in the improvement of the regulatory and legal framework; the anti-corruption culture must be clear and a priori, shared by all members of the organization; the anti-corruption culture of the organization can be formed through a clear, unambiguous and clear legal framework. At the same time, it should be noted that the anti-corruption culture of the organization consists of the culture of the profession and the actual anti-corruption culture of the organization.


Clusters by nature are the collection of similar objects. Each group or cluster is homogeneous, i.e., objects belonging to the same group are similar to each other. Also, each group or cluster should be different from other clusters, i.e., objects belonging to one cluster should be different from the objects of other clusters. Clustering is the process of group-ing similar objects. In this paper presents the brief literature survey work for an Optimal clustering techniques and other. The optimization techniques will also provide the better results in the terms of better efficiency for clustering techniques.


As an aid in the design of an electromagnetic system for the detection, monitoring, and mapping of the burn front of an underground (in situ) coal gasification process, an analytical model has been developed that will predict the electromagnetic field reflected from the gasified portion of the coal seam. The coal and gasified section have been modeled electrically as lossy media, surrounded above and below by relatively high conducting overburden and underburden. Vertical and horizontal electric and magnetic dipoles have been investigated, utilizing a geometrical optics formulation which also takes into account the physical roughness of the coal-overburden (underburden) and coal-gasified section boundaries. Indications are that a swept frequency monitoring system is capable of locating the burn front of the in situ gasification process, with the vertical electric dipole being the most attractive element.


Fluorinated organic compounds are applied as F2 laser resists due to their high transparency at 157nm. The relationship between numbers/positions of fluorine atoms in a repeating unit of the fluorinated polymers and their physical/chemical properties (solubility parameter and hydrophilicity) for F2 laser resist is discussed. Fluorine at suitable position improves hydrophilicity without lowering the solubility parameter.We propose a novel polymer suitable for F2 excimer laser resists consisting of the polymer with fluorine atoms connecting to proper positions.


To improve the accuracy of short-term time series forecasting,the idea of the combination model of ARIMA network and BP neural network is proposed.This combination model is built on the prediction of south-to-north water diversion project investment.First,a variety of order determination criteria is used for different ARIMA models to compare the prediction effects and the advantages and disad-vantages are pointed out.Then the BP neural network is utilizted for a further combination forecasting of these different ARIMA models.The results show that combination model gives full play to the advantages of the two models,it has a higer accuracy than a single prediction method and it works well in the time series of short-term forecast.


We introduce an explicit description of the $\Phi^4_3$ measure on a bounded domain. Our starting point is the interpretation of its Laplace transform as the value function of a stochastic optimal control problem along the flow of a scale regularization parameter. Once small scale singularities have been renormalized by the standard counterterms, $\Gamma$-convergence allows to extend the variational characterization to the unregularized model.


The results of endometrial aspiration as a means of early abortion in 59 private patients and 157 non-private patients are presented. Of the private patients, 31.1% had the procedure before 39 days of amenorrhea, while only 12.5% of the non-private patients were aspirated earlier than 39 days (P< 0.005). In both groups, approximately 80% of all pregnancy- tests were positive and approximately 85% of all patients were pregnant. Of 208 patients for whom tissue diagnosis was available, 15 patients revealed decidua only. Four of these required additional procedures. There were 9 complications. Although one patient required overnight hospitalization, none of the complications was a major fine. This complication rate is lower than comparable figures reported from the Joint Program for the Study of Abortion (JPSA). The concept of endometrial aspiration is a valuable addition for the management of contraceptive failure.


Introduction Klebsiella pneumoniae, as an opportunistic gram-negative pathogen, causes nosocomial infections such as septicemia, pneumoniae, and urinary tract infection (1-3). The growing occurrence of extended-spectrum β-lactamasesproducing K. pneumoniae led to the administration of carbapenem antibiotics potentially used to combat the multidrug-resistant strains of this bacterium (4). The first carbapenem-resistant K. pneumoniae (CR-Kp) was detected in 1996 in the United States (5). Unfortunately, in the recent decade, CR-Kp strains have been reported from several regions across the world (68). According to some studies (2,9,10), CR-Kp is created by the acquisition of one or more of the beta-lactamase classes of Ambler class A (i.e., KPC, NMC, IMI, SME, and GES), class B (i.e., IMP, VIM, GIM, SPM, and NDM), and class D (OXA-48). blaKPC, as a major carbapenem-resistant gen, has been reported in some studies worldwide (11,12). Today, 21 KPC (Klebsiella pneumoniae carbapenemase) variants have been identified (13) which are found worldwide (9). This gene could be carried by mobile genetic elements such as transposons and plasmids (14,15). As a plasmidborne carbapenemase, blaOXA-48 is barely related to other oxacillinases. On the other hand, its carbapenemhydrolysing potential is as strong as that of the KPC-1 enzyme (16). OXA-48 producers are mostly identified in K. pneumoniae and Escherichia coli. Nevertheless, they are reported to exist in the species of Enterobacteriaceae (17-19). Common molecular typing methods such as repetitive extragenic palindromic polymerase chain reaction (repPCR), multi-locus sequence typing, and pulsed-field gel electrophoresis to find the origin and relatedness of resistant clones could be pivotally useful for adopting subsequent controlling and preventing strategies (8,14). Hence, this study aimed to assess the occurrence of blaKPC and blaOXA-48 genes and find the similarity of the tested strains by rep-PCR among K. pneumoniae isolated from clinical specimens obtained from certain hospitals in Khorramabad, Iran. Abstract Objectives: Carbapenem-resistant Klebsiella pneumoniae (CR-Kp) is created by various mechanisms mainly including the production of Klebsiella pneumoniae carbapenemase (KPC) and other class A, B, and D beta-lactamases (e.g., OXA-48). The present study was undertaken to assess the occurrence of blaKPC and blaOXA-48 genes among K. pneumoniae isolates. Materials and Methods: In this cross-sectional study, 110 K. pneumoniae strains were collected from clinical samples from 2 teaching hospitals in Khorramabad, Iran. Susceptibility testing and modified-Hodge test (MHT) for K. pneumoniae isolates were performed according to Clinical and Laboratory Standards Institute procedures, followed by carrying out the detection of blaKPC and blaOXA-48 genes by polymerase chain reaction (PCR). Finally, genetic similarity among the tested strains tested was determined by the repetitive extragenic palindromic PCR (rep-PCR) method. Results: Up to 110 K. pneumoniae, the highest resistance and susceptibility rates pertained to ampicillin and ertapenem, respectively. In addition, 10 (9%) isolates were considered as carbapenemase-producing K. pneumoniae by the MHT. Although 13 (11.8%) isolates were blaOXA-48-positive, none of them were harboring blaKPC. Eventually, 13 and 44 clusters were distinguished in hospitals A and B by rep-PCR, respectively. Conclusions: The results of this study indicated that resistance to carbapenems among K. pneumoniae isolates were relatively common in our region. Moreover, the disseminated clones in our hospitals had mainly diverse origins.


The purpose of this study was to determine the level of emotional intelligence and the level of student achievement, as well as to determine whether there is a significant relationship between emotional intelligence and student achievement in social studies subject class IX SMP Negeri 10 Samarinda in the academic year 2021/2022. Sampling in this study used a probability sampling technique with proportional random, namely 78 students from 326 students of class IX SMP Negeri 10 Samarinda. The type of research used is quantitative research with a correlational approach. In an effort to collect data (research instruments), the author uses a Likert scale, namely the emotional intelligence scale which refers to the 5 (five) elements of emotional intelligence and documentation of student report cards to determine the value of learning achievement. Testing the validity of items and elements on the emotional intelligence scale was carried out by expert validation. To find the correlation between the two research variables, Pearson's Poduct Moment correlation was used and the analysis used the computer-assisted SPSS 23 for Windows program. Based on the results of the study, it showed that there was a significant relationship between emotional intelligence and student achievement in class IX of SMP Negeri 10 Samarinda. From the results of the calculation analysis, the value of sig = 0.000 and rcount = 0.407 means that the value of sig 0.000 < 0.05 and rcount is consulted with the rtable of product moment known to be at a significant level of 5% = 0.222, which means the value of rcount = 0.407 > rtable = 0.222. Thus the null hypothesis (Ho) is rejected and the alternative hypothesis (Ha) is accepted.


The purpose was to study what significance communication has for the psychosocial health of elderly deaf people who live in old peoples homes. I also explored how communication works between the staff.

- How do the staff feel the communication works between members of the staff and between the staff and the residents?

- How do the staffs think that the staffs' knowledge of the culture of the deaf community and sign language affects the psychological health of the residents?

- What changes have the staff noticed in the residents since they moved to the ward?

In order to accomplish study this area I have used semi-structured qualitative interviews and observations.

The main conclusion of this paper was that the possibility to communicate in ones own language was fundamental for the psychosocial health of the residents. The people I interviewed expressed that communication between the residents and the staff worked well, but communication was a problem between the staff members. Knowledge of the culture of the deaf and sign language, within the staff, had a positive influence on the psychosocial health of the residents. The people I interviewed have noticed a positive psychological and social change in the residents.


ABSTRACT This book is an update of a previous publication entitled Pilules mirages: Essai sur la qualité de vie des aînés. Recent statistics and a specific section on psychotropic drug use have been added to the latest edition. The main force of this book resides in its psychosocial perspective which highlights the association between non-medical factors and excessive drug use among the elderly. The importance of health beliefs and aging-related stresses are emphasized. As a conclusion, the authors put forth a systemic health-model of intervention for elderly drug abusers. In spite of their rather one-sided perspective, highly critical of the medical profession, the authors offer a good introductory text on excessive drug use by the elderly within a non-medical framework. This is suitable reading material for students in gerontological or addiction courses. It is also enlightening reading for any health professionals working with the elderly.


According to the characteristics and the existing problems of instrument and equipment management in universities,by combining with the theory of software engineering and project management,an information administration system based on B / S structure was designed and developed. The system had clear structure and held fully functions. By the system,the barriers among several departments were broken,and the data integration and interaction between different departments were achieved,and the processes of the assets administration were simplified. It made easier to use for the teachers and students in universities. In the near future,after the introduction of the mobile Internet and Internet of things,the system functions will be further expanded.


We continue to develop an obstruction theory for embedding 2-spheres into 4-manifolds in terms of Whitney towers. The proposed intersection invariants take values in certain graded abelian groups gener- ated by labelled trivalent trees, and with relations well known from the 3-dimensional theory of finite type invariants. Surprisingly, the same exact relations arise in 4 dimensions, for example the Jacobi (or IHX) relation comes in our context from the freedom of choosing Whitney arcs. We use the finite type theory to show that our invariants agree with the (leading term of the tree part of the) Kontsevich integral in the case where the 4- manifold is obtained from the 4-ball by attaching handles along a link in the 3-sphere. AMS Classification 57M99; 57M25


The 38th edition of the Symposium on Nuclear Physics was held at Hotel Hacienda Cocoyoc, Morelos, Mexico from January 6–9, 2015. As in previous years, the Symposium brought together leading scientists from all around the world, working on: nuclear structure, nuclear reactions, physics with radioactive ion beams, hadronic physics, nuclear astrophysics, neutron physics and relativistic heavy-ion physics. The scientific program consisted of 27 invited talks, proposed by the international advisory committee that covered, in a balanced way, the experimental and theoretical work that currently is undergoing in the research fields of the Symposium. Ten posters complemented the program, providing students with an opportunity to bring their work to the attention of visiting scientists. This year, the conference activities also included a special talk presented by Archaeologist Omar Espinosa Severino about the ancient ruins found in Chalcatzingo, a village located approximately a 40 minute drive from the conference venue. The talk was followed by a visit to the archaeological site, guided by the group led by Archaeologist Mario Cordova Tello. The present volume contains 14 research articles based on invited talks presented at the Symposium. I would like to thank all the authors for their enthusiastic contribution. Special thanks to the anonymous referees for the time devoted to the review process, their input helped to maintain a high standard of the Conference Proceedings. Finally I would also like to thank the Symposiums' International Advisory Committee and the Sponsoring Organizations that made this event possible.


The present invention relates to an oxidation process of hydroxybenzyl alcohols to prepare the corresponding hydroxybenzaldehydes. The object of the present invention is a process for preparation of a hydroxybenzaldehyde by oxidation of the corresponding alcohol hydroxybenzyl alcohol in the liquid phase, using molecular oxygen or a gas containing it, by operating in aqueous medium containing an alkaline agent, in the presence of a platinum catalyst and a cocatalyst based on a bismuth derivative, characterized in that the oxidation is conducted in the presence of a derivative boron.


Lipid-bound (VHb(406)) and lipid-free (VHb(402)) wide type Vitreoscilla hemoglobin were separated from E. coli BL21(DE3). The RZ is 3.30 for (VHb(406)) and 3.15 for (VHb(402)), respectively. VHb(406) shows a characteristic absorption band at 626 nm, while VHb(402) shows one at 644 nm, and it has more α-helix than VHb(402). Data of Raman spectra experiment shows under the excitation wavelength 488 nm, υ4 vibration of both VHb(402) and VHb(406) had a pure and strong signal at 1375 cm -1 , which proves that iron porphyrin of both the samples is at their trivalence oxidation state. And no matter lipid binds VHb or not, the vinyl of porphyrin is at cis state. The catalase activity of Vitreoscilla hemoglobin was explored with L-dopa and H2O2 as substrates. The results indicate that VHb(406) has more catalase activity than VHb(402), VHb is a cell's oxygen modulator and its catalase ability is modulated by the membrane. Keywords Vitreoscilla hemoglobin; Structure; Function; Membrane binding Article ID 1005-9040(2011)-03-450-05


The basic technique for the accurate calculation of the smallest (largest) eigenvalues and corresponding eigenvectors in large generalized eigenvalue problems arising in dynamic and buckling analysis are considered. This leads to the design of a very efficient practical algorithm when the system has small bandwidth. The solution technique combines an accelerated secant iteration in which the Sturm sequence of the leading principal minors is used with vector inverse iteration. Example analyses are presented to show typical convergence characteristics and solution times.


Using somatic embryogenesis system of Japanese larch that develops embryos composed of embryo-proper and suspensor, the effects of high-cell-density culture and conditioned medium on the somatic embryogenesis were investigated. High-cell-density culture strongly inhibited the somatic embryogenesis. Furthermore, the conditioned medium derived from high-cell-density culture also strongly inhibited the somatic embryogenesis, especially differentiation of the suspensor. The inhibitory effect of the conditioned medium was not attributable to the depletion of nutrients, but to the accumulation of inhibitory factor(s) in the medium. The addition of activated charcoal to high-cell-density culture resulted in the formation of numerous somatic embryos with longer suspensors than in the untreated one. This treatment also resulted in the formation of numerous vacuolated cells-like suspensor on the surface surrounding the embryo-proper. These results indicate that some inhibitory factor(s) that regulates suspensor differentiation are released into the medium of high cell density.


ARTICLE INFO With cloud storage services, it is ordinary for data to be not only stored in the cloud, but also shared across many users. However, public auditing for such shared data while conserving individuality privacy remains to be an open challenge. In this paper, we propose the first privacy-preserving contrivance that allows public auditing on shared data kept in the cloud. In particular, we deed ring signatures to compute the confirmation material needed to audit the truthfulness of shared data. With our contrivance, the candor of the signer on each slab in shared data is kept private from a third party auditor (TPA), who is still able to openly verify the truth of shared data without recovering the complete file. Our untried results establish the effectiveness and efficiency of our proposed contrivance when auditing shared data.


There is an increase in the production and consumption of plastics in day to day life. All plastics are disposed as waste after their usage. The need to intervene through proper disposal and management of waste plastics is very crucial. These call the use of thermal pyrolysis, which is a way of making these wastes to become very useful to us by recycling them to produce fuel oil. In this study, the pyrolysis reactor was design and manufactured for recycling of waste plastic into fuel working by the principle of thermal pyrolysis process. Three experiments are carried out to test the proper function of the reactor. It was found that about 84% of fuel obtained from one kilogram of plastic at temperature of 360°C. The feed stock that was used for the experiment was plastic wastes of polyethylene with different proportion LDPE and HDPE. The method feeding the feedstock to the reactor was by opining the top cover of the reactor for every batch. The reactor was heating externally using furnaces built for the purpose and at the outlet of reactor the condenser is attached to condense the vapors coming out of it. The reactor temperature was controlled by thermocouple sensor fixed inside the reactor and this sensor connected to an external PD controller. A separation procedure of fuel was employed by controlling the internal temperature of the reactor. Three types of fuel obtained from these experiments which are similar to gasoil, kerosene and diesel temperature range from 130°C - 230°C, 230°C -270°C and 230°C and above respectively. The fuel obtained from the experiment tested and characterized in national petroleum supply enterprise laboratory and meet the physical and chemical characteristic of fuels for different applications.


In this paper,the functions and significance of the teaching of chemical experiments in the process of chemical teaching were discussed.The requirements to the instructor of experiments and the implementation of strict requirements on the students were also included in the discussion.


The work considers the possibility of using metamaterials to design of low-gain antennas with improved parameters of antenna pattern. It is shown that additional elements of the antenna, made of metamaterial, can be considered as antenna array of parasitic emitters, forming antenna pattern of the required shape. It is shown that the use of metamaterial inserts allows to optimize irradiators for reflector and lens antennas.


The collisional loss of energy from vibrationally highly excited toluene molecules (excitation energy 52 000 cm−1) was monitored directly by time‐resolved UV absorption spectroscopy after laser excitation. Experiments were performed in a variety of bath gases heated up to 870 K with a modulated cw CO2 laser. Comparison with experiments at 300 K yields information on the temperature dependence of the average energy 〈ΔE〉 transferred per collision. The temperature coefficient of 〈ΔE〉∝T n was found to be close to zero (n=0.0±0.2) for monoatomic and diatomic bath gases; for larger bath gases small negative n values were found (n=−0.3±0.3). The results confirm earlier experiments on the steady‐state photoisomerization of cycloheptatriene which were reevaluated. They are in marked disagreement with recent conclusions on a strong decline of 〈ΔE〉 with increasing temperature.


A thermal stress test was conducted to determine the ability of the GPHS aeroshell 3-D FWPF material to maintain physical and mechanical integrity when exposed to a severe heat flux environment such as would occur from prompt reentry of GPHS modules. The thermal stress test was conducted in the Giant Planetary Facility (GPF) at NASA's Ames Research Center (ARC). In collaboration with Los Alamos Scientific Laboratory (LASL) GPHS project staff, Battelle designed a test model compatible with GPF size requirements. The test model was fabricated by LASL. Battelle designed, fabricated, installed, and checked out a unique strain measuring transducer to fit in the cavity of the test specimen. Preliminary thermal and thermal stress analyses of the test specimen were conducted by Battelle. These analyses showed that the GPF facility could easily reach heating rates that would produce temperatures and stresses in the test specimen of the same order as those computed in the GPHS module aeroshell for prompt reentry.


The present invention dietary supplements for rheumatoid arthritis prevention or improvement containing Eucommia ulmoides extract, rheumatoid arthritis preventing or pharmaceutical composition and the extract for the treatment containing the above extract as an active ingredient having anti-inflammatory activity and osteoclast inhibitory effect as an active ingredient relate to. Eucommia ulmoides extract of the present invention is a useful material in rheumatoid arthritis, there are excellent effects as a prophylactic and therapeutic agent for diseases related to rheumatism. Eucommia, hot water extract, rheumatoid arthritis, pharmaceutical compositions, dietary supplements


This paper considers the parameters estimation problem of wideband linear frequency modulation near-field signal sources on the basis of fractional Fourier transform and propagation method. Firstly, the uniform linear sensor array is used as the receiving array. Due to the LFM signal has the characteristic of energy concentration in the fractional Fourier transform domain, the received signal model is established by utilizing this feature. Then we construct the covariance matrix, and make subspace decomposition by the propagation method to construct the space spectral functions of Multiple Signal Classification algorithm. Finally, we implement the peak searching to estimate the Direction of Arriva (DOA) and range of the wideband LFM near field signal sources. Moreover, a sufficient and effective statistical analysis is also carried out which consummates the method theoretically, and the simulation results show the effectiveness of the proposed algorithm.


Tax revenue mobilization has remained one of the greatest challenges confronting governments of most countries in the Sub-Saharan Africa. Empirical evidence suggests that the level of tax revenue has been declining in the region, while financing gap becomes wider. In understanding this phenomenon, earlier studies on taxation focused on supply factors without much consideration for the demand factors in explaining low tax generation. On this ground, this study extended the conventional tax model to incorporate public governance factors in terms of control of corruption, democracy and accountability as well as rule of law to investigate the impact of these factors on tax revenue in the Sub-Saharan Africa. The study covers 42 Sub-Saharan Africa countries, for the period 2002 to 2015 and data were obtained from World Bank database. Based on the Feasible Generalised Least Square approach, the study found that the control of corruption, rule of law, as well as democracy and accountability have positive significant relationship with tax revenue level in SSA. The study concluded that public governance factors are also important in determining tax revenue in SSA and we recommended that governance factor should be given desirable attention by the policy makers if tax revenue collection is to be enhanced in Africa


ABSTRACT The modern narrative of Vietnamese people is often strongly associated with events of the 20th century, such as the Vietnam War, but a legacy of strife in Southeast Asia spans many centuries. Enduring stress and trauma has pernicious psychological and physiological repercussions that have affected first and later generations of Vietnamese American refugees. To contextualize the present-day narrative, we review the history of Vietnam and the contemporary refugee experience in the United States. We then examine more proximal spheres of influence, including community and family. Finally, we review individual experiences of stress and trauma. We present recommendations to inform individual, group, family, and community-based counseling interventions, as well as recommendations for future research.


Finite difference schemes are considered for a diffusion equations, which discribe buffering by using stationary and mobile buffers. Stability and error estimates of approximate solutions for the corresponding schemes are obtained using the extended Lax-Richtmyer equivalence theorem.


Quantum computation has attracted much attention, among other things, due to its potentialities to solve classical NP problems in polynomial time. For this reason, there has been a growing interest to build a quantum computer. One of the basic steps is to implement the quantum circuit able to realize a given unitary operation. This task has been solved using decomposition of unitary matrices in simpler ones till reach quantum circuits having only single-qubits and CNOTs gates. Usually the goal is to find the minimal quantum circuit able to solve a given problem. In this paper we go in a different direction. We propose a general quantum circuit able to implement any specific quantum circuit by just setting correctly the parameters. In other words, we propose a programmable quantum circuit. This opens the possibility to construct a real quantum computer where several different quantum operations can be realized in the same hardware. The configuration is proposed and its optical implementation is discussed.


Abstract Two restored DVD editions of Carl Theodor Dreyer9s Vampyr (1932), show at last how the director constructed its mysterious and menacing narrative, replete (as Swaab argues) with themes of parental violence and sexual transgression.


Although various methods and techniques for managing the mass production and quality control of software products have been developed, a majority of existing software factories have adopted the modular approach to program development and testing. 1-6 Indeed, this approach has become fundamental to large systems software factories mainly because practical software modules (such as functions, subroutines, tasks, abstract data-type packages , or subsystems) have interfaces that are clearly defined and displayed. The most common software production schema, the life-cycle model, has further provided software developers with a basic set of development phases that has precipitated the development of many computer-aided management support tools and systems. The phases of the life-cycle model are so well conceived and defined that they too have become fundamental to many large systems software factories. However, new production management tools and systems are now required to further supplement the existing ones; these new tools and systems have not been derived from the life-cycle model. Prototyping, reusing, and program generating are the three most prominent innovations of these recent studies. Prototyping is a system that provides users and designers with a means of forecasting software implementation results during the early stages of software design. 7 Reus-ing is a system for facilitating the retrieval and reuse of existing software. Program generating automatically constructs other programs; although a number of program generators with specific applications have been used in the past, general-purpose program generators, such as ones that utilize knowledge bases, 8-10 are expected in the future. This article presents a possible schema for incorporating these systems into existing production schemes; also presented are some management concepts that have evolved in studies on software reliability, 11,12 quality assurance, 13 software productivity, 14 and the cost model. 15-17 Scope of software The software treated in this article is application software for large systems such as process control, factory automation, traffic control, electric power dispatch control , and nuclear power station control. 18 Though the software is less costly than its controlling systems, it is usually very large; for example, the code required to control a power generation unit exceeds two million lines. Consequently, most software development projects continue for a period exceeding three years. The software of these computer systems consists of application software and subsidiary application packages, a utility subsystem, and an operating system. Application software is used for accessing common resources such as arithmetic calculations, comnputations of some …


The article widely describes the concept of author's modality in the context of linguistic research and provides a brief history of the study of the category of modality in modern linguo-stylistics and text linguistics. Author's modality is considered as a category that plays the role of compiler, organizer of the literary text. The author's modality was also studied as a communicative-pragmatic and subjective assessment category. In such works as Kazakh writer A. Kekilbayev's novel "Aṅızdıṅ aqırı" and Kyrgyz writer Sh. Aitmatov's novel "Kıyamat", famous American writers Theodore Dreiser's novel "Jennie Gerhardt", Oscar Wilde's "The Picture of Dorian Gray" the different ways of expression the category of author's modality were studied, and similarities and differences were identified.


The symposium will focus on trans-national constructions of the 'good'
teacher through popular culture, through professional development orthodoxies
and through professional practices such as professional growth plans, inspection
and teacher regulation.


Accurate imaging to identify hypoxic regions in tumors is key for radiotherapy planning. [F-18]-fluoromisonidazole ([F-18]-FMISO) is widely used for tumor hypoxia imaging and has the potential to optimize radio-therapy planning. However, the biological characteristics of intratumoral [F-18]-FMISO distribution have not yet been fully investigated. In hypoxic cells, the hypoxia-inducible factor-1 (HIF-1) target proteins that induce cellular prolif-HIF-1) target proteins that induce cellular proliferation and glucose metabolism, glucose transporter-1 (Glut-1) and hexokinase-II (HK-II), are upregulated. In this study, we determined the intratumoral distribution of [F-18]-FMISO by autoradiography (ARG) and compared it with pimonidazole uptake, expression of Glut-1, tumor proliferative activity (Ki-67 index) and glucose metabolism ([C-14]2-fluoro-2-deoxy-D-glucose uptake; [C-14]-FDG) in a glioma rat model. Five C6 glioma-bearing rats were injected with [F-18]-FMISO and [C-14]-FDG. After 90 min, the rats were injected with pimonidazole and 60 min later, the rats were sacrificed and tumor tissues were sectioned into slices. The adjacent slices were used for ARG and immunohistochemical (IHC) analyses of pimonidazole, Glut-1 and Ki-67. [F-18]-FMISO ARG images were divided into regions of high [F-18]-FMISO uptake (FMISO+) and low [F-18]-FMISO uptake (FMISO−). Pimonidazole and Glut-1 expression levels, Ki-67 index and [C-14]-FDG distribution were evaluated in the regions of interest (ROIs) placed on FMISO+ and FMISO−. [F-18]-FMISO distribution was generally consistent with pimonidazole distribution. The percentage of positively stained areas (% positive) of Glut-1 in FMISO+ was significantly higher compared to FMISO (24±8% in FMISO+ and 9±4% in FMISO−; P<0.05). There were no significant differences in Ki-67 index and [C-14]-FDG uptake between FMISO+ and FMISO− (for Ki-67, 10±5% in FMISO+ and 12±5% in FMISO−, P = ns; for [C-14]-FDG, 1.4±0.3% ID/g/kg in FMISO+ and 1.3±0.3% ID/g/kg in FMISO−, P = ns). Intratumoral [F-18]-FMISO distribution reflected tumor hypoxia and expression of the hypoxia-related gene product Glut-1; it did not, however, reflect tumor proliferation or glucose metabolism. Our findings help elucidate the biological characteristics of intratumoral [F-18]-FMISO distribution that are relevant to radiotherapy planning.


Physiological tone, to laymen, generally refers to muscular ®rmness or general physical ®tness. The word actually originates in an ancient Greek root that refers to stretch or strain. That may explain its use in reference to musical pitch and, by extension, to sounds, colours, and moods. In the biomedical world, tone especially designates the resistance to stretch that characterizes tissues containing muscle. Such resistance arises both from the ®xed physical properties of the tissue (passive resistance) and from the energy-consuming activation of the contractile apparatus of the muscle (active resistance). Somatic muscle contracts in response to stretch, and the absence of such contraction (loss of tone) signi®es neurological disease. Many physicians and physiologists commonly use the term `tone' to refer only to the active resistance to stretch, that which arises from muscle contraction. For this reason, such terms as `active tone' and `passive tone', as occasionally encountered, are confusing and unnecessary because other terms exist to make the distinction between active and passive mechanical properties. All tone is active. The concept of tone, of course, has slipped into other aspects of physiology, appearing in such terms as `tonic secretion', `tonic nerve discharge', etc. The concepts of stretch and strain have disappeared from the term in such usage, but the implications of constancy and of physiological or energy-consuming activity remain. Tone exists in visceral muscle as it does in somatic muscle. The concepts of arterial and venous tone are important in cardiovascular physiology. The notion of muscle tone is an essential one in gastrointestinal physiology as well. Tone in gut muscle, however, received comparatively little attention until recent decades, when its signi®cance in the motility of the gastrointestinal tract became evident.


Piperazine-based drugs, such as N -benzylpiperazine (BZP), became attractive in the 2000s due to possessing effects similar to amphetamines. Herein, BZP, in addition to its pyridyl analogues, 2-, 3-and 4-pyridylmethylpiperazine (2-PMP, 3-PMP and 4-PMP respectively) were subjected to the hyperpolarisation technique SABRE (Signal Amplification By Reversible Exchange) in order to demonstrate the use of this technique to detect these piperazine-based drugs. Although BZP was not hyperpolarised via SABRE, 2-PMP, 3-PMP and 4-PMP were, with the ortho - and meta -pyridyl protons of 4-PMP showing the largest enhancement of 313-fold and 267-fold respectively in a 1.4 T detection field, following polarisation transfer at earth's magnetic field. In addition to the freebase, 4-PMP.3HCl was also appraised by SABRE and was found not to polarise, however, the addition of increasing equivalents of triethylamine (TEA) produced the freebase, with a maximum enhancement observed upon the addition of three equivalents of TEA. Further addition of TEA led to a reduction in the observed enhancement. SABRE was also employed to polarise 4-PMP.3HCl ( ca. 20% w/w) in a simulated tablet to demonstrate the forensic application of the technique (138-fold enhancement for the ortho -pyridyl protons). The amount of 4-PMP.3HCl present in the simulated tablet was quantified via NMR using D 2 O as a solvent and compared well to complimentary GC-MS data. Exchanging D 2 O for CD 3 OD as the solvent utilised for analysis resulted in a significantly lower amount of 4-PMP.3HCl being determined, thus highlighting safeguarding issues linked to drug abuse in relation to determining the amount of active pharmaceutical ingredient present. This details the employment of SABRE to hyperpolarise BZP and the PMP derivatives in both their hydrochloride and freebase forms utilising benchtop NMR (60 MHz) for detection. The PMP derivatives are pyridyl analogues of BZP and as such, could be synthesised by clandestine laboratories to circumvent current legislation. Thus, although 2-, 3- and 4-PMP have not been reported as being abused recreationally, they represent future potential forensic targets. An emphasis is placed on the detection of 1 H polarisation only. The effect of the addition of base (triethylamine (TEA)), on the enhancement observed for both freebase and hydrochloride forms of 4-PMP.3HCl is examined. Lastly, the extraction, and subsequent hyperpolarisation and quantification, of 4-PMP.3HCl from a simulated pill is detailed, in order to highlight how the approach could be applied to forensic casework. This paper describes the employment of SABRE to hyperpolarise BZP, 2-, 3- and 4-PMP, as well as the hydrochloride salts of BZP and 4-PMP. These studies revealed that BZP.HCl could not be polarised under the conditions employed, due to inability of the ligand to chelate to the metal centre of the SABRE catalyst employed, [Ir(IMes)(COD)Cl]. Addition of either 1.2 or 2 equivalents to either partially or completely freebase BZP still resulted in no enhancement of the signals in the 1 H NMR spectrum due to hyperpolarisation transfer.


Quevedo wrote Heráclito cristiano in 1613; traditional criticism always saw it as his first personal crisis and others as his first and deliberate i r í d H i s p n , pp 61 seriousness), and proclaim intimate projects of transformation, and neutralization of previous stages is obsessive. The pragmatic circumstances of public repentance in this text can be interpreted as a vindication to be taken seriously by the elites of his time, thus neutralizing his social image of the obscene satirist in his early works. This interpretation is particularly endorsed if we accept that his political rise to Secretary of the Viceroy of Spain in Italy —a political promotion that took place right after Heráclito cristiano — could be considered as a perlocutionary effect of the text itself.


A discussion of a paper with the aforementioned title by J-L. Briaud, F.C.K. Ting, H.C Chen, R. Gudavalli, S. Perugu, and G.P. Wei, published in this journal (Volume 125, Number 4, April 1999), is presented. Because dispersive clays can develop unusual erosional features, such as jugs, the discusser believes that the authors' proposed method cannot be used to evaluate these clays. He suggests that the best approach is to use the "pinhole test" (American Society for Testing and Materials D4647-93 1999) to identify highly dispersive clays and then make sure the bridge footing is founded below the depth of the highly dispersive clay.


Assuming that the barotropic vorticity equation is valid at the non-divergent level, the author discusses the displacement of a circular model perturbation superimposed on a basic motion and gives a generalized formula of Rossby's long wave theory. This theory is applied to the displacement of typhoon in the subtropical zone and the author proposes a graphical forecasting method of typhoon movement. 1. Fundamental equation Consider the motion at the non-divergent level, then the motion may be described as where V (x, y, t) is the horizontal velocity vector, x and y are the horizontal co-ordinates pointing to east and north respectively and t is the time, * the horizontal gradient, * the Coriolis parameter and * the vertical component of relative vorticity. The field of motion may be regarded as to be made up of two parts, namely a basic motion and a perturbation superimposed on it. Thus we may write where V and * refer to the basic motion and V' and * are the corresponding perturbation quantities. Substituting Eq. (2) into Eq. (1), we obtain 2. Displacement of a circular model perturbation Here, we give a circular model perturbation which travels without altering its shape, given by where Z' is the perturbed contour height, Z0 an arbitrary constant, J0 the zero-th order Bessel function, * the distance from the perturbation center and * the radius of the outer boundary of the perturbation. Some values of J0(2.4 */*) are shown in Table 1.


Here we describe an uterine vascular leiomyoma with a fat component which occurred in a 43-year-old woman. The tumor arose on the left parametrial wall of the uterine body. Pathologically, it was composed of thick-walled tortuous vessels and irregular bundles of smooth muscle cells, and was mixed with fat. The smooth muscle cells were immunoreactive for actin, desmin and vimentin. They were negative for cytokeratin, HMB-45, CD34, S-100 protein, progesterone receptor and estrogen receptor. Retrospectively, abdominal magnetic resonance images showed a well-demarcated mass of isointense signal on T1-weighted image, heterogeneous high signal intensity on T2-weighted images with thin tubule-like enhancement, suggesting tortuous vascular structures within the mass. Albeit rare, these radiologic findings may be helpful in distinguishing the vascular leiomyoma from other smooth muscle tumors. In our opinion, the histologic and immunohistochemical sharing features of uterine smooth muscle tumors may be responsible for underestimated incidence of this type of leiomyoma.


The notion of «speculative individual» represents, for Hegel, the philosophical way of apprehending the modern principle of the individual, but reserving for it an ethical perspective, i.e. socially mediated.


Purposes  :  The purpose of the creation of this comic is to create new innovations and business opportunities and improve community awareness of local wisdom in North Sumatra.
Methods   :  The methods implemented in this activity include data collection, product creation and marketing.
Findings  :  Comics legend of North Sumatra is a result of the innovation from the  comics generally serving as a means to preserve the local wisdom. Now the local wisdom is about the story of the people or the legends located in North Sumatra. The end result of the product is in the form of comic books and also digital application.
Keywords  :  Comics, Local wisdom, and Implementation methods.


As the abundance and diversity of antibiotic resistance genes increases in the environment, there is a concurrent increase in the threat to public and ecosystem health. Extracellular antibiotic resistance genes (eARGs) are cellfree DNA that can promote the development of antibiotic resistance via transformation by competent bacterial cells. Despite this role, eARGs have not been well characterized in different environmental waters. Their small size and low concentrations in some aquatic environments render them difficult to extract. The aim of this research was to modify an eARG extraction method to determine the abundance of both eARGs and intracellular ARGs (iARGs) in the same water sample. The modified method, consisting of sequential filtration to separate iARGs from eARGs, adsorption-elution with aluminum hydroxide–coated silica gel, and precipitation, extracted eARGs and iARGs with a recovery rate between 79.5% and 99.0%. The novel method was then utilized for the extraction of the extracellular and intracellular fractions of four ARGs, one mobile genetic element, and the 16S rRNA in tap water, river surface water, lake surface water, stormwater, and wastewater effluent. This is the first instance in which the extracellular and intracellular fractions of the 16S rRNA, iiiitttt1, bbbbaaTEM, eeeeeeF, ssssbb1, and tteettC genes in stormwater and lake surface water are reported. In addition, this modified method enabled the quantification of the extracellular concentration of the erythromycin resistance gene eeeeeeF in environmental waters for the first time; the gene's abundance ranged from 1.26 × 105 to 8.82 × 106 gene copies/L across the aquatic waters sampled. The extracellular abundance of the mobile genetic element iiiitttt1, moreover, was quantified in tap water (7.00 × 104 gene copies/L) for the first time. The validation and application of this method to diverse environmental matrices should allow for further research to be conducted to better understand the role of eARGs in the spread of antibiotic resistance.


"Wellness" is a philosophy of life that has been increasingly successful in economically developed countries, as a response to lifestyles that have obvious negative consequences on the health of the population. It is based on a constant physical activity, a balanced diet and a positive mental approach. The adoption of this lifestyle could also have a positive impact on the prevention of kidney stones. According to the latest findings, a balancing of the content in lipids, proteins and carbohydrates of the diet with low intake of salt, saturated fat, simple carbohydrates (sugar) and cholesterol and an increased intake of fruits, vegetables and whole grains is highly desirable in renal stone patients. However the consumption of whole grains, vegetables and fruits should be modulated in order to avoid an excessive intake of oxalate and fructose. Regular and moderate exercise has the prerequisites for a positive effect in reducing the risk of kidney stone formation, although at the time the epidemiologic evidence of this positive effect remains weak. The capacity to adapt to stressful events of daily life could have a favorable effect on the risk of forming kidney stones as the amount of stressful events proved to be greater in patients with kidney stones.


Preface Overeducation in the Australian Graduate Labour Market: The Roles of Immigrant Status & Language Background Overseas Workers & the Role of Professional Associations Case Studies of Disadvantaged Students Reading Motivation: Avoiding a Deficit Perspective Aboriginal & Torres Strait Islander People in Australia, Education & Health Literacy Index.


Response and fracture of cement-treated layers in flexure are significantly influenced by their load-deformation characteristics in tension and compression and their tensile strength. The purpose of this paper is to use the flexure beam test to investigate the flexural behavior of a cement-treated silty clay and a cement-treated sand mix. Specifically, material properties such as tensile and compressive moduli, flexural moduli, tensile strength, flexural strength, and tensile strain at failure are determined for different compaction variables, cement contents, and curing ages. The observed difference in tensile and compressive moduli (i.e., bimodular properties) is explained using proposed mechanistic models, and the practical significance of bimodular behavior is illustrated.


Fidgetin like-1 protein (FIGL-1) is a homolog of fidgetin, a protein whose mutation leads to multiple developmental defects. FIGL-1 protein contains an AAA (ATPase associated with various activities) domain, and belongs to the AAA superfamily. However, the biological functions and developmental implications of this protein remain unknown. Here, we show that the AAA domain of the C. elegans FIGL-1 protein (CeFIGL-1-AAA), in clear contrast to homologous AAA domains, has an unusually high ATPase activity and forms a hexamer in solution. By determining the crystal structure of CeFIGL1-AAA, we found that the loop linking helices α9 and α10 folds into a short helix α9a, which has an acidic surface and interacts with a positively-charged surface of neighboring subunit. Disruption of this charge interaction by mutagenesis diminishes both the ATPase activity and the oligomerization capacity of the protein. Interestingly, the acidic residues in α9a of CeFIGL-1-AAA are not conserved in other homologous AAA domains that have relatively low ATPase activities. These results demonstrate that the sequence of CeFIGL-1AAA has adapted to establish an intersubunit charge interaction, which contributes to its strong oligomerization and ATPase activity. These unique properties of CeFIGL-1-AAA distinguish it from other homologous proteins, suggesting that CeFIGL-1 may have a distinct biological function. Mutation of the protein fidgetin in mice (fidget mice) results in the induction of multiple developmental defects, such as small eyes, polydactyly, and reduced or absent semicircular canals (1-4). However, the linkage between fidgetin mutation and the phenotype of fidget mice is unclear. Sequence analysis shows that fidgetin contains an AAA (ATPase associated with various activities) domain, and thus belongs to the AAA superfamily (1). The members of this extensive superfamily possess either one or two conserved AAA domains in their C-terminus, and use the energy derived from ATP hydrolysis mediated by the AAA domain to perform various biological functions, including protein unfolding, nucleosome remodeling, and microtubule disassembly (5-7). http://www.jbc.org/cgi/doi/10.1074/jbc.M113.502559 The latest version is at JBC Papers in Press. Published on August 26, 2013 as Manuscript M113.502559 Copyright 2013 by The American Society for Biochemistry and Molecular Biology, Inc. by gest on M arch 4, 2020 hp://w w w .jb.org/ D ow nladed from Strong intersubunit interaction of CeFIGL-1-AAA 2 To do so, AAA proteins often assemble into ring-shaped hexamers through interaction between AAA domains of each subunit. While the AAA domain of these proteins serves as the site of ATP hydrolysis and hexamer formation, the region N-terminal to the AAA domain is often the substrateor partner-binding site, the conformation of which is tightly coupled to the nucleotide state of the AAA domain (6,8). Structurally, the AAA domain consists of a large and a small subdomain, with the cleft between them serving as the nucleotide-binding and hydrolysis sites. Several conserved motifs, including Walker A, Walker B, sensor 1, sensor 2, and Arg finger, have been found to be important for the binding and hydrolysis of ATP (7,8). A series of studies have established that ATP hydrolysis in one AAA domain is dependent on the binding of the neighboring AAA domain that is likely mediated by the direct contact of the conserved Arg finger motif in the neighboring AAA domain (7,8). Thus, oligomerization is generally required for the ATP hydrolysis activity of AAA proteins. Within the AAA superfamily, fidgetin is classified as a member of the subgroup that includes spastin and katanin (9); these three proteins all have been shown to have microtubule severing activity and to be involved in multiple microtubule-related biological events, such as axon branching, cytokinesis, and ciliogenesis (10-13). Among these, spastin has been studied the most extensively, because mutation of spastin accounts for approximately 40% of all cases of autosomal dominant hereditary spastic paraplegia (14). The crystal structure of the AAA domain of spastin has been determined, and the critical residues have been extensively studied in the context of the functional spastin protein (11,15). On the other hand, the biological functions of katanin and fidgetin are far less clear (12). Fidgetin like-1 (FIGL-1) was identified as a homolog of fidgetin through genome database searching (1). Thereafter, FIGL-1 was found to be important for mitotic progression of the germ line in C. elegans (16) and may be involved in testis development in mice (17). Recently, C. elegans FIGL-1 was found to bind to SUMO (18). Although some critical residues have been identified in C. elegans FIGL-1 (19,20), its direct target and biological activity have not been identified, and the structure of FIGL-1 is not known yet. Thus far, only the structure of the AAA domain of human FIGL-1 has been determined (PDB 3d8b), and has been shown to have very weak ATPase activity (21). To better understand the function of FIGL-1, we expressed the AAA domain of C. elegans FIGL-1 (CeFIGL-1-AAA) in E. coli and studied its structure and ATPase activity. We found that CeFIGL-1-AAA has a strong intrinsic ATPase activity, and is oligomeric in solution, as shown by gel filtration chromatography and analytical ultracentrifugation. The crystal structure of the AAA domain was then determined in nucleotide-free and ADP-binding states. Although the overall structure of CeFIGL-1AAA is highly similar to that of other AAA proteins, CeFIGL-1-AAA contains a charge interaction at the potential interface between subunits. Interruption of this charge interaction by mutagenesis diminished both the ATPase activity and oligomerization of CeFIGL-1-AAA. These results demonstrate that the oligomerization interaction between subunits is essential for the ATP hydrolysis activity of CeFIGL-1. Furthermore, this unusually strong intersubunit interaction of CeFIGL-1 may be related to its unique physiological function. Experimental Procedures Protein expression and purification. CeFIGL-1 cDNA was kindly provided by Dr. Kunitoshi Yamanaka, Kumamoto University, Japan. The Ser261-Arg594 coding region was cloned into a pET-28a vector and expressed in the BL21(DE3) Rosseta strain. The recombinant protein was purified using HisTrap and Mono Q columns (GE Healthcare). Mutations were introduced using the Quick change method. For the purification of D540KE543K double mutant, Mono S column was used instead of Mono Q. ATPase activity assay. The steady state ATPase activity of 1 μM CeFIGL-1-AAA was measured using an enzyme-coupled assay in 50 mM Tris-HCl (pH 8.2), 75 mM NaCl, 1 mM DTT, 2 mM MgCl2, 1 mM EGTA, and various concentrations of ATP at 25°C, as described previously (22). The turnover numbers per subunit were calculated. ATPase activity was fitted using the Michaelis-Menten equation with Hill coefficient as follows: where [F] is the concentration of CeFIGL-1AAA, [ATP] is the concentration of ATP, KM is v = kcat ![F]![ATP] h KM h +[ATP] by gest on M arch 4, 2020 hp://w w w .jb.org/ D ow nladed from Strong intersubunit interaction of CeFIGL-1-AAA 3 the Michaelis constant, and h is the Hill coefficient. Size exclusion chromatography. Wildtype and mutant CeFIGL-1-AAA proteins were analyzed using a Superdex 200 10/300 GL column (GE Healthcare) in 20 mM Tris-HCl (pH 8.2), 50 mM NaCl and 0.5 mM βmercaptoethanol. The flow rate was 0.5 ml/min. Analytical ultracentrifugation. Determination of sedimentation velocity (SV) was performed in a Beckman/Coulter XL-I analytical ultracentrifuge using double-sector and sapphirine windows. Before the experiments, an additional protein purification step was performed using a Superdex-200 size exclusion column (GE Healthcare) in 20 mM Tris-HCl (pH 8.0), 150 mM NaCl. The experiment was performed at 40,000 rpm and 285 K using interference detection and doublesector cells loaded with approximately 2 mg/ml protein in the absence or presence of 3 mM nucleotide. The buffer composition (density and viscosity) and the protein partial specific volume (V-bar) were calculated using the SEDNTERP program (available through the Boston Biomedical Research Institute). The data were analyzed using SEDFIT and SEDPHAT programs (23,24). Crystallization and data collection. Crystals of nucleotide-free and ADP-bound CeFIGL-1-AAA were grown using the vapor diffusion method by mixing 1 μl protein solution with 1 μl reservoir solution at 293 K and a protein concentration of 2 mg/ml. Nucleotide-free crystals were produced in a reservoir solution of 0.1 M Tris-HCl (pH 7.0), 0.5 M sodium malonate (pH 6.0), and 0.3% PEG 10,000 by the sitting drop method. After 3 days, the crystals were harvested and frozen in Paratone-N. To obtain crystals of ADP-bound CeFIGL-1-AAA, 5 mM ADP was added into the protein solution for crystallization, and crystals were produced in a reservoir solution of 0.1M Bis-Tris (pH 6.5), 0.5 M sodium acetate by the hanging drop method. After 1 week, the crystals were harvested and frozen in a cryoprotectant consisting of the reservoir solution supplemented with 25% glycerol. The data from nucleotide-free and ADPbound crystals were collected by in-house X-ray and the Shanghai Synchrotron Radiation Facility (SSRF), respectively. Both crystals belong to the space group P65. The nucleotidefree crystals diffracted to 2.6 Å with unit cell dimensions of a = b = 108.5 Å and c = 55.0 Å. The ADP-bound crystals diffracted to 2.8 Å with unit cell dimensions of a = b = 113.5 Å and c = 58.1 Å. Both datasets were processed and scaled using the HKL2000 software package


Aiming at the FPGA-based implementation for quickly acquiring GPS signals,an acquisition algorithm based on circular correlation was proposed in this paper.Then,both the method sampling the C/A code and the solution resampling the IF signal were analyzed in detail.On the basis of the acquisition algorithm,an FPGA-based implementation structure was presented and simulated.The simulation results show that the system can acquire the GPS signals when the power is about-130dB,and save the hardware overhead.


Abstract: Quality cost management presents significant challenge for managers at Croatian and other airports. The former way of measuring business perfomance was based on passenger traffic, cargo traffic, aircraft traffic and financial results, without the analysis of impact of quality costs on business results. The cost which was produced due to (non)quality has not been recorded at all, and the lack of managers' knowledge of the content and structure of quality costs and the possibility of applying modern methods of quality cost tracking presented a considerable problem, which in turn prevented a satisfactory quality cost management. As a specific type of cost, the quality costs represent a certain financial reserve that we can define and direct to business activities. These can then contribute to competitiveness, which is very important in the present recession period. It is recommended to improve characteristics of airport management system by the implementation of ISO 9001 norm requirements, which are the necessary infrastructure for building a quality cost management system. The research, as the platform for this paper, is focused on the development degree of quality cost management systems at the Croatian airports. In the research we used scientific cognitive methods with emphasis on statistical method, comparative method, as well as on the methods of induction and deduction. Primary research was conducted at the seven airports in Croatia: Dubrovnik, Osijek, Pula, Rijeka, Split, Zadar and Zagreb. The research results show the implementation and certification phase of ISO 9001:2008 quality management system, as well as the development degree of quality cost management systems at the Croatian airports.


Objective:To explore the curative effect using method of nourishing Yin and dispelling wind in treatment of laryngeal cough(type of yin-deficiency and wind-dryness)and the influence of airway resistance.Methods:Fifty objects who suffered from laryngeal cough were selected.Thirty in treatment group being given Xuan mai cough instant granule and twenty in control group being given Ji zhi syrup.Xuan mai cough instant granule was thawed in boiling water,taken orally and drinking 200mL twice every day.Ji zhi syrup was also taken orally and drinking 20mL three times every day.Both duration is 7 days.We observed the change of clinical symptoms and airway resistance'index.Results:Clinical heal rate、notable effective rate、effective rate and inefficiency rate in treatment group respectively are 3.3%、53.3%、40%、3.4%,and meantime 0%、5%、35%、60% in control group.Data analysis indicated that treatment group apparently higher than control group.Leading symptoms,Clinical heal rate,notable effective rate、effective rate are all better than control group.Further more,indexes of Zrs、R5、R20、R35 are remarkable reduced in treatment group and the efficacy is better than control group.Conclusion:The method of nourishing Yin and dispelling wind can remarkable relieve a cough.It apparently reduce airway resistance.Test of IOS can be the objective index to diagnose laryngeal cough and evaluate efficacy.


The proportionality of the logarithm of the mobility to the square root of the electric field is most likely caused by the broadening of the density of states according to both the Gaussian disorder model and the 3D correlated disorder model (CDM). Using these models, the relation between the slope of the mobility against the electric field and the dipolar component of the width of the density of states ((sigma) d) is analyzed. The (sigma) d for the donor and the host polymer are calculated using the dipolar disorder model in which a random distribution of permanent dipoles generates fluctuation in electric potential. A successful interpretation of the relation between (beta) and (sigma) d has been achieved using the formula based on the CDM. Assuming that all components of the density of states are described using Gaussian statistics, the van der Waals component is evaluated to be negligibly small from analyses of temperature dependence of the relation between (beta) and (sigma) d. The experimental results also shows that the value of the DOS width that is derived from the analysis of the temperature dependence of the zero-field mobility is different for the value of the DOS width that is derived from the analysis of the electric field dependence.


Acute mesenteric ischemia (AMI) is a rare vascular disease characterized by a high mortality rate with untimely diagnosis and treatment. The overall incidence is low, estimated at 0.09–0.2 % of all hospital admissions to emergency departments. One of the causes of acute mesenteric ischemia is acute arterial thrombosis, which is most common in the elderly.The problem of early diagnosis of acute mesenteric thrombosis is still relevant due to a non-specific clinical features. Computed tomography angiography (CT angiography) of the abdominal aorta and its branches is characterized by high sensitivity (85–98 %) and specificity (91–100 %). Computed tomography angiography is the gold standard for the diagnosis of acute mesenteric ischemia.The article discusses the use of computed tomography angiography (CT angiography) for visualization of acute mesenteric thrombosis.


The parameterization of vertical transport due to cumulus clouds is often performed by a massflux approach (Tiedtke, 1989). In such schemes it is assumed that the cumulus cloud field can be well represented by a top-hat distribution. An important variable that needs to parameterized is the convective massflux (Mc), Mc ≡ σs(ws − w) = σs(1 − σs)(ws − we), (1) which is usually diagnosed from the continuity equation for mass, ∂Mc ∂z = − ∂σs ∂t +E −D, (2)


This paper describes the implementation of an antenna-in-package (AiP) with a dual polarization function, supporting a three-dimensional (3D) beamforming operation. In order to implement 3D beamforming, a Yagi-type end-fire antenna supporting each of the x and y directions and a patch-type broadsided antenna supporting the z-direction were implemented. The broadside antennas have dual polarization functions so that they can be received in any direction. Each antenna was implemented in four array structures to support beamforming operations. The broadside antenna was designed in a 2 × 2 array structure, with a patch-type antenna and two linear dual polarization functions. The single antenna operated with a gain of 6 dBi, an E-plane beam width of ±45 degrees, and an H-plane beam width of ±50 degrees and had an antenna gain of 9~11 dBi as well as a vertical/horizontal forming operation with a radiation angle of ±22 degrees The end-fire antenna unit was designed in a 1 × 4 array structure with a Yagi-type antenna. The single antenna had a gain of 4 dBi, with an antenna gain of 8 dBi in the array structure, and it was improved to 11 dBi by adding a parasitic array director. The final end-fire antenna unit had a radiation angle of ±11 degrees and a beamforming coverage of ±45 degrees The vertical and horizontal design results were secured for reception in any direction, and all the array antennas had a return loss of 10 dB or less in the entire frequency band, from 57 to 66 GHz.


EPX gene is a member of the peroxidase gene family and is expressed in eosinophils. The gene is found in a cluster of three peroxidase genes at chromosome 17q23.Mutations in this gene result in eosinophil peroxidase deficiency. Till date, there is very less work undertaken on the gene. Thus the current work aims to analyze and annotate the gene both sequentially and functionally. The work also includes the mutation analysis based on the variable sites present in the sequences when compared among the related organisms. The complete variation analysis along with the identification of possible deleterious mutations has been performed. As the structure of the protein is not reported in the literature, modeling approach was employed using modeler 9v3 to design its structure. The structure thus generated was also screened and validated for the quality using several parameters. The work can provide a stable platform for further investigation and research on EPX gene and its importance. Introduction:This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23.Mutations in this gene result in eosinophil peroxidase deficiency. Materials and Methods:EPX protein sequence Retreival :Eosinophil Peroxidase protein sequences were retrieved from the National Center for Biotechnology Information (NCBI) [www.ncbi.nlm.nih.gov]. Ten more EPX sequences of related organisms are selected. The selected sequences were converted to FASTA format. Sequence analysis:Sequence alignments: Multiple sequence alignment was performed with ClustalW. The ClustalW alignment file was generated. Phylogenetic analysis by means of dendrogram of the protein sequences was performed using the alignment obtained with ClustalW and visualized in tree top viewer. Conservation studies using BOX SHADE: To study the conservation pattern of the protein sequence with respect to the sequences of the other organisms BOX SHADE tool has been employed that would align the sequences using Global alignment method. This tool specifically performs multiple sequence alignment in order to identify and analyze the conservation pattern and evolutionarily strong sites present within the sequences. Domain identification using SMART: SMART is an online tool which performs the internal BLAST of the input sequence with the sequences in the CDD database to identify the total number of domains present Helix Vol. 3:555559 (2014) 556 Copyright © 2014 Helix ISSN 2319 – 5592 (Online) in the given sequence along with the information regarding the functions of each domain. The tool also provides information about the other elements like low sequence repeats, signal peptides etc. Disorder Analysis using Insilco tools: Disorder analysis was performed using several tools like SIFT and RONN. The first two tools will enable the user to select or identify the regions of high mutability or disorderness based up on the input sequence. RONN will not only specify the regions of mutability but it also provides the disorder probability for each residue based upon which the main target site having maximum mutability can be selected. Analyzing the effect of Mutations on the stability and Functionality of the proteins: Poly Phen was employed to analyze the effect of the substitutions of wild type amino acid with the new amino acid in the native sequence under study. This tool would study the functional effect whereas the I mutant is useful to calculate the effect of substitution mutations on the energy and stability of the protein sequence. Based upon the results of the disorder prediction tools like RONN the regions of mutability were identified followed by the selection of the sites responsible for major mutations. Once the sites are identified the effect of substitution of these sites with any of the other 19 amino acids was studied by the I mutant and Poly Phen tools. Result and Disscussion:SMART RESULT:Functional analysis using SMART Based on the results of smart it can be observed that there is only one functional domain named An_ peroxidase extending from 145 to 689 positions in the amino acid sequence. The major function of these Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions. Fig 1: SMART results showing the domain present in the query sequence Helix Vol. 3:555559 (2014) 557 Copyright © 2014 Helix ISSN 2319 – 5592 (Online) Fig 2: BOX SHADE for the conservation study From the Fig2of BOX SHADE analysis it can be concluded that all the sequence of the EOSINOPHIL PEROXIDASE protein among the selected organisms has been conserved and they show maximum identity. Helix Vol. 3:555559 (2014) 558 Copyright © 2014 Helix ISSN 2319 – 5592 (Online) Disorder analysis using RONN:RONN was used to analyze the disorder prone regions in the query sequence. The results showed that the maximum probability of disorder was found to be in the region FRRAR from 641645positions. Thus, these regions are used for the further analysis. Table 2: Disorder probability and Tolerability for the selected region 640645 AMINO ACID POSITION PROBABILITY SIFT ANALYSIS F 641 0.34 TOLERATED R 642 0.33 TOLERATED R 643 0.32 TOLERATED A 644 0.32 TOLERATED R 645 0.32 NON-TOLERATED 645=y,w,v,t,s,q,p,n,m,l,k,i,h,g,f,e,d,c,a Fig 3: Regions of Disorder as shown by RONN The peak in the above figure indicates the probability of the disorder at that specific site. The horizontal line indicates the threshold value. Helix Vol. 3:555559 (2014) 559 Copyright © 2014 Helix ISSN 2319 – 5592 (Online) Generation of the Protein structure using Modeller 9v12 Fig 4: The Best Model Structure Generated: TvLDH.B99990097.pdb 19431.47070 -73399.81250 1.00000 Validation of the structure generated: Fig 5: Ramachandran plot Generated for the Predicted Structure From the above Ramachandran plot the following inference can be made, thus the structure is acceptable. RESIDUES IN FAVOURED REGIONS= 91.4% #RESIDUESIN ALLOWED REGIONS= 7.7% #RESIDUES IN DISALLOWED REGIONS= 0.2% Conclusion:The work involved the complete characterization of epx. Initially the sequence of the gene was retrieved from Gene cards database and the domains were identified using the SMART tool. The complete variability analysis was performed based on the results of MSA using CLUSTAW. The variability patterns were identified using a combination of the results obtained from RONN and SIFT. The work would provide an insight to the effect of change in the sequence on the tolerability, stability and functionality of the gene. The structure of the protein was modeled using Modeller 9v12 and the validation of the structural quality was performed in Saves server. The results of validation showed the quality of the structure to be 91.3% which indicates a very good structure for the


In production manufacturing systems, raw materials that are required for the production process are supposed to be present in sufficient quantities. The ordering of these products is given by an inventory management policy. We consider in this paper raw materials, that are present in sufficient quantities and that can be stored for a long time in containers under specific conditions (temperature, pressure, …). The peculiarity is that the quality of these raw materials decreases as soon as they are open for being used. At this moment, the product has to be used before a given deadline, or it is lost. Two types of objective functions are associated to the use of such raw materials: the total cost of lost products (economic objective) and the total quantity of lost products (environmental objective). We present in this paper this new scheduling framework, which brings new constraints and new objective functions. We show that the single machine problem with equal-length jobs and only one product is already NP-hard and we propose mathematical formulations for two single-machine problems and an MIP model, which is briefly evaluated.


The Internet of Things era has been fueling the need for functional printed and flexible devices, and a variety of printing technologies address this need. State of the art inkjet and aerosol jet techniques deliver ink nanoparticles to the substrate and then require an annealing or curing step in order to obtain consolidated thin films needed for device fabrication. Thus, these are three-step processes including pre-treatment of substrate, printing and curing, requiring multiple pieces of equipment. Plasma jet printing, in contrast, accomplishes all the needed steps in the printer itself using the plasma, and the energetic environment of the plasma results in a "self-sintering" effect, providing a consolidated film upon printing. A variety of metals, oxides, carbon nanomaterials, electromagnetic interference shields, antennas and others have been successfully printed using plasma printing and an overview of the plasma printing, equipment and demonstrated results is presented here.


Uranium(V) has been prepared photochemically; its uv spectrum shows a peak at 255 nm with an extinction coefficient of 660 L mol/sup /minus/1/ cm/sup /minus/1/. Conventional uv/visible, stopped flow, and laser flash photolysis techniques have been used to study the electron-transfer reactions of uranium(V) and uranium(VI) with a range of chromium, ruthenium, and cobalt complexes. Application of Marcus theory to these results suggest a uranium(VI)/uranium(V) self-exchange rate constant in the range 1-15 L mol/sup /minus/1/s/sup /minus/1/. Some of the cross-reactions appear to be nonadiabatic, and these are slower than predicted. 20 references, 4 figures, 4 tables.


More than 6 million New York residents will have access to Web camera or telephone physician encounters, according to BlueCross BlueShield of Western New York and American Well.


Morphological and Crystallographic Studies on the Oriented Transformation in γ‒FeOOH and its Decomposed Oxides (Special Issue on Electron Microscopy) Author(s) Takada, Toshio; Kiyama, Masao; Shimizu, Shigeki Citation Bulletin of the Institute for Chemical Research, Kyoto University (1965), 42(6): 505-510 Issue Date 1965-07-15 URL http://hdl.handle.net/2433/76040 Right Type Departmental Bulletin Paper Textversion publisher


Over the last two decades, university education in the EU has undergone a transition from elitist to mass education. Consequently, in 2000 the university student population in the EU numbered some 12.6 million, constituting 5 percent of the population of working age (15 to 64). Italy, Switzerland, Denmark and Austria are at the lower end of university participation, Belgium, France and Greece at the upper end.


Reconfigurable slit‐masks are used with sensor arrays to observe and measure spectra of stars. In space‐based applications, such as the James Webb telescope, or ground‐based applications where detectors are operated at low temperatures, a reconfigurable slit‐mask system must be capable of operating at cryogenic temperatures while generating a small additional heat load. A proposed design consists of a series of small electromagnetic clamps and piezoelectric actuators, and a single prototype has been manufactured. This work focuses on the development of a test apparatus for experiments characterizing various components of the slit‐mask device as well as preliminary results from those experiments. Development focused on the cryostat used for the experiments as well as the performance of the electromagnetic apparatus for measuring clamping force. Results outline the final designs for apparatus components as well as preliminary results of a nickel iron alloy electromagnetic clamp.


Objective To understand and grasp the basic public health services in Panzhihua City,the status of human resource of Panzhihua City,for the progressive realization of equalization of basic public health services provided on the basis of.Methods Using a self-designed questionnaire of Panzhihua engaged in the 64 essential public health services medical institutions responsible for investigating,SPSS for Windows 13.0 database was used and statistical analysis was conducted.Results Engaged in the 64 essential public health services primary health care institutions,public health and part-time staff of 404 people,an average of 6.3,one of 21 community health service center 206,an average of 9.8,full-time staff of 30 people,an average of 1.43,had specialized in public health education and public health practitioner qualifications were 6 and 4 respectively;43 township health centers in 198,an average of 4.6,full-time staff of 156 people,an average of 3.63,had specialized in public health education and public health practitioner qualifications were 8 and 9 people respectively.Conclusion Panzhihua city basic public health service structure remained to be improved,efforts should be made to improve public health professionals,and strive to improve the public health service personnel professional quality.


In order to reach the management aim of the enterprise and embody the value and dignity of human being, the emphases of enterprise human resource management is how to make good use the manpower of the enterprise reasonable and effective. Both the declination of the employee's loyalty and the trust crisis of the professional managers are endangering the development and survival of the enterprises. As a very important spirit factor, morality plays a very important role in the enterprise human resource management. It can enhance the employee's loyalty and the professional managers trustfulness and availably decline the cost of human resource management and increase the work efficiency of the employees. These will availably realize the purpose of human resource and attain the purpose of the enterprise.


Channel coded orthogonal frequency-division multiplexing (COFDM) is considered under narrowband interference (NBI). Analytical expressions for the bit error probability (BEP) are derived for COFDM with and without space-frequency coding (SFC) in a frequency-selective fading environment. It is shown that SFC increases the resistance of COFDM against NBI and reduces the BEP considerably. Specific attention is paid to Digital Television Terrestrial Broadcasting (DTTB), and the associated coding gains are discussed. I. INTRODUCTION


Purpose To identify and quantitatively evaluate age related changes in the retinal pigment epithelium (RPE) and underlying Bruchs membrane and choroid in donor human eyes. Methods 36unpaired human eyes of varying age (3~93 years) from Caucasian donors were supplied by Manchester Eye Bank (UK) or National Disease Research Interchange (Philadephia,USA).Modified Massons trichrome staining was used to illustrate age related changes in RPE cell, Bruchs membrane thickness, and density of choriocapillaries and thickness of the choroid. Data were assessed using computer aided quantitative morphometric analysis method. Results The thickness of Bruchs membrane increased with age while there is a change in morphology of RPE cells including a decrease in number and RPE cell thickening with age. RPE cells decreased at a rate of 8 cells/mm 2·year, RPE cell height and thickness of Bruchs membrane increased at rates of 0.01(μm/year) and 0.02 (μm/year) respectively. The luminal area of choriocapillaries and the thickness of choroid showed no close relation with age. Conclusion RPE cell loss and thickening of Bruchs membrane and RPE cells may be the earlier and primary alteration with age.


This study aims to determine: career planning prepared by students class xi in
choosing majors in college. Second, to know what the stub after plotting his career
graduate high school students. This is the kind of research qualitative approach
ethnography. Object of this research is school tuition class xi. Which has been used
for their families were thirteen as speakers including five student of class xi ips, five
student of class installations ipa as well as xi and the remaining buses, the school
principal and two teachers. This research result indicates that of the ten students have
been planning planning his career of them , four students want to proceed college,
one student want to be a soldier, one person wanted to be a cop, and four but people
want to be entrepreneurs. As for the exception of pilot conducted grader student of
several in planning his career , from come to know of the prospect of work through
the medium of the internet , ask teacher or those who have been working , ask
relatives who are seated on a bench in college about advanced education, improve
their performance, and following the course of private or tutoring.


This paper constructs the three variables influence relationship model of urban fireworks festival tourism——resident participation,perception and support,taking Changsha Orange Island fireworks show for example,and uses application questionnaire,correlation analysis and regression analysis to explored it. The results show that: there is a weak negative correlation between perceived cost and support of residents,while weak positive correlation with participation,which is different from others; residents' participation and perceived benefits had direct positive impact on support degree,while perceived costs did the opposite way; the degree of impact on the residents support from strong to weak was perceived benefits,perceived cost and participation,which has important implications on urban fireworks tourism management.


Conservatory measures in the matter of trustee John Lukca and trustee firm J. Lukca & Associes Inc. given to Daniel Robitalile (July 4, 2006).


Sovereign immunity — Foreign sovereign entities — Association of Italian Knights of the Order of Malta — Whether entitled to immunity from taxation — Whether entitlement analagous to entitlement to jurisdictional immunity — Whether distinction between acts iure gestionis decisive — The law of Italy


In spring 2009, Chrysler entered a prepackaged bankruptcy and existed 40 days later in a deal with Fiat, the U.S. Treasury, and the UAW that kept the automaker alive. Looking forward, what was necessary for Chrysler to move beyond the life support it had received? What was possible? Looking back, how should the company's restructuring be assessed?Learning Objective:To illustrate leadership in a real time crisis.


Higley Basin, located near the western margin of the Basin and Range Province in central Arizona, is a deep (>3,000 m), Miocene half-graben characterized by displacement along both highand low-angle normal faults; displacement along these faults has created accommodation space for thick volcanic sequences followed by more recent fluvial, alluvial, and colluvial deposits. Higley Basin occupies a unique location near a transition in the vergence of major detachment fault systems largely responsible for the exhumation of a belt of metamorphic core complexes in the region. To the west and north, major detachment faults generally dip to the northeast, while to the south and east of the basin, major detachment faults generally dip to the southwest. Kinematic arguments require these detachment surfaces to terminate in a zone between the two fault domains (zone of accommodation), trending roughly parallel to regional extension. Interpretation of geophysical datasets from central Arizona indicate that oppositely vergent, low-angle faults partly terminate as branching, overlapping fault systems within Higley Basin and the immediate vicinity. Features other than those within the basin must also partly accommodate the opposing vergence of the two dominant detachment systems. Thus, the zone of accommodation is inferred to extend either to the northeast buried beneath later volcanic rocks of the Superstition Mountains or to the southwest beneath young surficial deposits. Multiple major fault systems are observed or inferred to decrease in throw and tip out within or near Higley Basin. As slip along an individual structure is reduced, the formation of local, large-offset detachment surfaces is prevented. This could preclude sufficient tectonic unloading to promote isostatic response of the lower plate in the detachment system and may preclude the development of core complexes near the terminations of detachment domains. Also, the lack of major isostatic response may prevent progressive back rotation of major fault systems near their terminus, and thus the faults remain at steeper dips and produce a deeper


The larvicidal efficacy of synthetic pesticides, Temephos and Imidacloprid against An. stephensi and Cx. quinquefasciatus reveals that Temephos was more effective. The larval mortality after the treatment of different encapsulated nano-formulations of individual temephos and imidacloprid reveals that PEG with optimum loading of 8% temephos was the most potent among encapsulated synthetic pesticides against both mosquitoes.


In recent years student-centered active learning has received considerable attention in tertiary education. Calls for educational reform and alternative approaches to traditional instruction have led many proponents of active learning to advocate for its effectiveness. Supporters argue that students who are more actively engaged in their learning process, as opposed to passive recipients of information, will be more likely to obtain meaningful understanding of required


The outbreaks of acute respiratory infectious disease with high attack rates on cruise ships were rarely studied. The outbreak of COVID-19 on the Diamond Princess Cruise Ship provides an unprecedented opportunity to estimate its original transmissibility with basic reproductive number (R0) and the effectiveness of containment measures. The traditional deterministic approach for estimating R0 is based on the outbreak of a large population size rather than that a small cohort of cruise ship. The parameters are therefore fraught with uncertainty. To tackle this problem, we developed a Bayesian Susceptible-Exposed-Infected-Recovery (SEIR) model with ordinary differential equation (ODE) to estimate three parameters, including transmission coefficients, the latent period, and the recovery rate given the uncertainty implicated the outbreak of COVID-19 on cruise ship with modest population size. Based on the estimated results on these three parameters before the introduction of partial containment measures, the natural epidemic curve after intervention was predicted and compared with the observed curve in order to assess the efficacy of containment measures. With the application of the Bayesian model to the empirical data on COVID-19 outbreak on the Diamond Princess Cruise Ship, the R0 was estimated as high as 5.71(95% credible interval: 4.08-7.55) because of its aerosols and fomite transmission mode. The simulated trajectory shows the entire epidemic period without containment measurements was approximately 47 days and reached the peak one month later after the index case. The partial containment measure reduced 34% (95% credible interval: 31-36%) infected passengers. Such a discovery provides an insight into timely evacuation and early isolation and quarantine with decontamination for containing other cruise ships and warship outbreaks.


Augmented levels of IL‐1ß have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro‐IL1ß cleavage and IL‐1ß secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome' genes and preeclampsia.


Climate and environmental changes in the Late Glacial and Holocene in the Southern Baltic area based on investigations of malacofauna and ostracod assemblages: their influence on pre-existing biocoenoses. A b s t r a c t. The climate changes and related crucial environmental changes in the Late Glacial and Holocene in the Southern Baltic area can be investigated by mollusc and ostracod analyses. It is well known that accumulation of mineral and biogenic sediments in the Southern Baltic area began in the Late Glacial. The process took place in cold tundra lakes and mires. The presence of lake basins is confirmed by seismoacoustic investigations and the resulting 3D spatial model. Lacustrine sediments contain an assemblage of molluscs and ostracod fauna represented by freshwater species indicating cold climate, such as: Armiger crista f. cristatus, Gyraulus laevis, Lymnaea peregra, Pisidium casertanum, Pisidium casertanum f. ponderosa, Pisidium milium, Pisidium nitidum, Pisidium obtusale f. lapponicum, Valvata cristata, Pisidium conventus, Candona candida, Candona neglecta, Cytherissa lacustris, Darwinula stevensoni and Cypridopsis vidua. The accumulation in freshwater reservoirs was continued during the Early Holocene. Besides cold freshwater species, sediments of that age also contain freshwater species of molluscs and ostracods that required higher temperature: Bithynia tentaculata, Physa fontinalis, Pisidium amnicum, Candona compressa and Metacypris cordata. It indicates a climate warming in the Preboreal period. These lake sediments were partly destroyed and covered by marine sands during the Middle and Upper Holocene. Good indicators of changing from a freshwater to marine environment are the following marine species found in the sediments: Hydrobia ulvae, Hydrobia ventrosa, Cerastoderma glaucum, Mytilus edulis, Macoma balthica, Cyprideis torosa and Cytheromorpha fuscata.


A dual-element MIMO antenna with enhanced bandwidth of 0.038THz (0.457-0.495THz) by using DGS is presented for THz applications. By utilising a rectangular slot in the ground plane, the suggested MIMO antenna's maximum return loss and isolation are, respectively, -28dB and -31.8dB at the resonant frequency (0.475THz). The diversity performance of MIMO is also studied with ECC < 0.001, DG ≤ 9.98dB and mean effective gain (MEG)-ratio within ±3 dB. The 720×520× 60μm3 dimension Rogers RO4003 substrate, which has a εr of 3.55 and a loss tangent of 0.0027, serves as the foundation for the proposed MIMO antenna. The planned MIMO radio wire is reasonable for fast brief distance correspondence, video rate imaging, and detecting in the THz band.


Many groundwaters in the midwestern US have a high sulfate (S04) concentration (1000-3000 mg/L) and are extremely hard. These characteristics are caused by the dissolution of gypsum deposits (CaS04) as the water percolates toward the aquifer. The hardness is not associated with alkalinity; its removal by conventional chemical processes necessitates the addition of large quantities of lime and soda ash, producing voluminous amounts of sludge without reducing the S04 concentration. Concentrations of S04 in excess of 250 mg/L render water unpalatable and have a purgative effect. In concentrations greater than 1000 mg/L, S04 can be harmful to livestock and some crops.1 In the past, treatment of high sulfate, hard waters has been unnecessary since better quality sources were available and more economical to use. However, the increased demand for high quality water has already made necessary the treatment and use of previously unacceptable sources. Under these circumstances the


The ultrasonic technique is essentially a non-rotary method of cutting dental hard tissue and restorative materials using piezo-electric oscillations. Cutting dentine structure with ultrasonic tips is analogous to cutting dentine with the thinnest bur imaginable. Ultrasonic instruments play an ever-increasing role in several aspects of endodontic treatment. Teeth with root canal obstructions are no longer automatically treatment for has the procedure of In root canal obstructions are in a more conservative that does not destroy the The identification of and hidden has become a predictable rather than a serendipitous Access cavities are being cut and refined with greater precision, opening up gateways to better endodontics. Above all, these procedures are no longer being performed blindly; instead the clinician is now able to maintain visual contact with the operating field at all times during ultrasonic procedures. bone necrosis. It shown that as little as 15–20 s of continuous dry ultrasonic to injurious when