Electroforming technology was used to prepare Ni/SiC composites in the nickel sulphamate bath with SiC as reinforcing particles.The effects of process parameters on SiC content in Ni/SiC composites were investigated by means of Leica Qwin graphics analysis software.The effects of particle content in composites on microhardness were also analyzed by microhardness instrument.FESEM was used to observe the section surfaces and the distribution of SiC in the composites.The results showed that the maximum volume fraction of SiC in Ni/SiC composites was 27% under the conditions of current density of 3 A·dm-2,particle concentration of 50 g·L-1 and agitation rate of 1.5 time/min.In addition,the maximum composites microhardness was 710 HV.


This article offers some reflections on this special issue of Politics and Psychotherapy International. The author identifies in the various articles, a number of repeated themes: the violence inherent in neoliberalism stemming from its very first application in Chile; the ongoing and far-reaching effects of colonialism, particularly in its manifestations through globalisation; the negation of the rights of the poor, including the right to accurate information; and increasing pressures on workers to do more for less, and very often more of what is least important. Copyright © 2016 John Wiley & Sons, Ltd.


call for different explanations) and to Hilbert's remark that the "pure thought constructions" involved in the application of the axiomatic method cannot be regarded as true or false (which Hallett quotes, but without considering its bearing—ostensibly very considerable—upon the contrasted approaches of Hilbert and Fregeto foundational matters). As may be clear from my summary of its contents, this collection, like many conference volumes, exhibits little significant thematic unity. But that need not be a fault. Certainly it includes several papers worthy of careful study. BOB HALE


It analysed cause of servo-valve flequently dumage of 300 MW unit EH system and AST oil-pressure decrease instantly.Through analyse and Looking for it findsout that is because of the in insufficient burnning of primary oil ciircu lating and too high of local tempercatue of anti-oil burning.The problam was solved through changing oil,filter oil and decrenge temperature so as to ensure safty and steably running of the units.


A reasonable explanation of the confounding wave-particle duality of matter is presented in terms of the reality of the wave nature of a particle. In this view a quantum particle is an objectively real wave packet consisting of irregular disturbances of underlying quantum fields. It travels holistically as a unit and thereby acts as a particle. Only the totality of the entire wave packet at any instance embodies all the conserved quantities, for example the energy-momentum, rest mass, and charge of the particle, and as such must be acquired all at once during detection. On this basis, many of the bizarre behaviors observed in the quantum domain, such as wave function collapse, the limitation of prediction to only a probability rather than a certainty, the apparent simultaneous existence of a particle in more than one place, and the inherent uncertainty can be adequately understood. The reality of comprehending the wave function as an amplitude distribution of irregular disturbances imposes the necessity of acquiring the wave function in its entirety for detection. This is evinced by the observed certainty of wave function collapse that supports the paradigm of reality of the wave function portrayed in this article.


Aims: This study was undertaken to assess the effectiveness and safety of insulin aspart in patients with gestational and pregestational diabetes. Settings and Design: An open-label, prospective, nonrandomized, comparative, and observational study conducted at single center in India. Subjects and Methods: A total of 276 patients were in gestational diabetes mellitus (GDM) group, 79 were in the pre-GDM group. Patients were started on insulin therapy (insulin aspart ± neutral protamine hagedorn) once medical nutrition therapy for 2 weeks failed to achieve control, that is., fasting plasma glucose ≥90 mg/dL and/or 1.0 h postprandial plasma glucose ≥130 mg/dL. Insulin dose was titrated to keep the blood glucose values between 90 and 130 mg/dL. Patients were followed once every 4 weeks until the 28th week, then once every 2 weeks until 32nd week, then once every week until delivery, and the final visit was on 60 ± 7 days. The final outcome was assessed in terms of incidence of macrosomia (>3.5 kg body weight) between the two groups and episodes of confirmed (blood glucose <56 mg/dL) minor or major maternal hypoglycemia. Results: There was no statistically significant difference among the two groups in terms of incidence of macrosomia that is., it was 5.1%, 8.9% in GDM, pre-GDM group, respectively. Conclusions: Insulin aspart was found safe in pregnancy, however, more studies with double-blind, standard controlled studies are required to confirm the findings of this study.


Introduction: Neuroblastoma (NB) is one of the most common malignant extracranial solid tumors in children, mainly detected in children between the ages of 22 months to five years. It can develop in any location of the sympathetic nervous system. Although it has a broad spectrum of signs and symptoms, it is hard to find cases with major respiratory manifestations. Case Presentation: Our case report presents a 50-day-old male admitted to a local hospital with respiratory distress and cyanosis. Then, he was intubated and transferred to our pediatric center for further evaluation. Our investigation found a mass in the mediastinum with lung involvement. This patient is a rare case of neuroblastoma that occurred earlier in the age of onset with uncommon respiratory manifestation, unresponsive to outpatient treatment. Conclusions: We presented a neuroblastoma case with persistent respiratory manifestations that repeatedly received outpatient treatment for respiratory diseases, but his condition did not improve. Physicians should always suspect this condition in addition to other differential diagnoses, especially in patients unresponsive to outpatient treatment, with abnormal chest X-rays and respiratory symptoms.


OBJECTIVE:To investigate the use of antibiotics in patients infected with pseudomonas aeruginosa in order to strengthen physicians' attention to rational administration and to improve the rational drug use level in hospital.METHODS:The use of antibacterials in 87 cases pseudomonas aeruginosa infection was analyzed retrospectively to evaluate the rationality of drug use.RESULTS:Pseudomonas aeruginosa infection mostly occurred in old age,with lung infection and urinary tract infection showing the highest percentages.Dominating the first 6 places in terms of DDDs were cefoperazone /sulbactam,piperacillin /tazobactam,cefpiramide sodium,fluconazol,cefotiam,levofloxacin.Cephalosporins and enzyme inhibitors were dominantly used,followed by the carbapenem and fluoroquinolones.CONCLUSION:In treating the infection of pseudomonas aeruginosa,drug choice should be based on the susceptibility test results and the antibacterials should be used rationally according to patients' condition.


To the Editor: —In the current number of the American Journal of Syphilis , Dr. A. S. Warthin of the University of Michigan contributes an extraordinary paper on the "New Pathology of Syphilis," in which he states that, as a result of microscopic methods, he has been able to demonstrate syphilitic changes in 40 per cent, of 750 subjects examined postmortem. Assuming that the population of the state of Michigan is neither more nor less venereally unfortunate than that of other localities, Dr. Warthin's statement naturally suggests that 40 per cent. of humanity is demonstrably if not dangerously syphilized. Happily for the individual as well as for a profession that is already sufficiently if not unduly impressed by the ubiquity of syphilis, the methods by which Dr. Warthin arrived at this remarkable and disquieting conclusion are not beyond dispute, identical methods in other hands having failed to yield comparable results. For


A graph G is called hamiltonian if it contains a Hamilton cycle, i.e. a cycle containing all vertices. Deciding whether a given graph has a Hamilton cycle is an NP-complete problem. But, it is a polynomial problem within some special graph classes. In this paper we consider three classes of grid graphs, namely rectangular grid graph, eta grid graph and omega grid graph. Our main result characterizes which of these graphs are hamiltonian.


In this way, we reported the results of the scanning electron microscopic on cysticercus cellulosae in vitro, treated with chinese materia medica (CMM) of compound mienangling and simple prescription of scorpia or alum and niter. All of which had marked destructive effect to cysticercus cellulosae. We recommend the use of compound mienangling instead of the simple ones in clinic for the damaging power of the former is apparently superior to the latter.


We explore the scalar field quintessence freezing model of dark energy with the inverse Ratra-Peebles potential. We study the cosmic expansion and the large scale structure growth rate. We use recent measurements of the growth rate and the baryon acoustic oscillation peak positions to constrain the matter density $\Omega_\mathrm{m}$ parameter and the model parameter $\alpha$ that describes the steepness of the scalar field potential. We solve jointly the equations for the background expansion and for the growth rate of matter perturbations. The obtained theoretical results are compared with the observational data. We perform the Baysian data analysis to derive constraints on the model parameters.


Critical Thinking (CT) in educational practice has become a universal term for crafting many state and national standards. Ennis (2008) outlines two different approaches used to define the term: epistemic approaches--a consensus approach that argues CT can be arrived at through various stakeholders including philosophers, policymakers and the individual herself—as championed by Facione (1990), the National Center for Educational Statistics (1995), and Ennis himself (2002); and a second approach, more relativistic, as argued by Fischer and Scriven (1997), Johnson (1996) and Paul (1993), who suggest that CT must be considered dialectic with an emphasis on persuasion, resolution of disputes and context. In either scenario, both groups argue CT "seeks the truth—to try to get it right" (Ennis, 2002, p.8).


The character of current university dormitory network and the problems existed in the management were analyzed in the paper,based on the successful experience of that of Dalian Nationalities University,an effective management pattern of university dormitory network was proposed.


This research involves the development of spectrophotometric method for determination of pyridoxine hydrochloride by oxidative coupling reaction with N,N-dimethylparaphenylenediamine dihydrochloride (DMPPDAD ( in a basic medium (pH 11.6) in the presence of  potassium ferricyanide to produce an intense green colour, soluble in water, stable product and absorbs at 650 nm. Beer's law was in the linear range 6-30 μg/ml of pyridoxine hydrochloride, the molar extinction coefficint, Sandell's sensitivity index and detection limit were 4.338 × 103 L. mol-1.cm-1 , 0.0474 μg.cm-2 and 0.756 μg/ml respectively. The RSD value was 0.63 - 1.41% depending on the concentration. This method was applied successfully to the determination of pyridoxine hydrochloride in pharmaceutical preparation samavite B6 tablet with recovery of not less than 99.5%.


A full-wave analysis is made for a nonradiative dielectric (NRD) guide T-junction. It is developed on the basis of a mode-matching scheme combined with a cascading procedure that allows formulating generalized admittance and generalized scattering matrices. Results obtained by this technique are compared with HFSS results and they are found to be in excellent agreement. Our calculations indicate a strong coupling that may take place between LSE and LSM modes among ports of the junction.


A Monte Carlo method for pricing high-dimensional American options is considered. The consistency of the stochastic mesh method is studied. Some "natural" estimators of this method have infinite variance. A modification which gives consistent estimators for a diffusion model is proposed. It is shown that the variance of estimators is inverse proportional to the number of points in each layer of the mesh. Keywords–Optimal stopping; American option; Stochastic mesh.


In this research, recrystallization of AA7020 aluminum alloy after hot compression testing was predicted using a framework being a combination of physical modeling and Monte Carlo simulation. Stored energy was calculated as a function of subgrain size related to the Zener Hollomon parameter. The as-deformed grain structure was mapped into the Monte Carlo simulation from experimental results. Calculated stored energy was assigned to the mapped structure, considering the length scale of the simulation. Results were validated by comparing the microstructures obtained from the model predictions with those from experimental results and a reasonable agreement was reached. The predicted grain size was found to be 15 % smaller than the experimental values. Predicted fractions recrystallized showed a similar trend to the experimental results. However, a discrepancy between the model predictions and experimental results in terms of recrystallization kinetics was found, which was attributed to neglecting the effect of subgrain growth and resulting reduction of the stored energy during recovery on the recrystallization kinetics in the present simulation.


In this paper, according to the characteristics of enterprise reporting, authors put forward an ideology that break down a report into multiple rowobjects and then add the corresponding rowobject embedded report or cell, this idea has greatly enhanced the efficiency and normal of generating a report; in function, process of generating a report is divided into report structural layer, and data integration layer, through visual reportstructure design and data integration on parameter passing, achieve a complete user -defined report generation successfully. Finally, accomplish systemdevelopment using .NETtechnology and used very well in an automobile manufacturing enterprise.


Based on exeperiments,a method was described for the eliminating the interference of Gold and mercury with the N-allyl-N′-(sodium-p-benzenesulfonate)thiourea in the indentification of barium using Rhodizonic acid sodium salt?.Comparing with the traditional method,the new method has some advantages.It is simple and can eliminate the interference completely.Moreover the experimental conditions are easy to control.


In this paper, we deal with { K , s + 1 } -potent matrices. These matrices generalize all the following classes of matrices: k -potent matrices, periodic matrices, idempotent matrices, involutory matrices, centrosymmetric matrices, mirrorsymmetric matrices, circulant matrices, among others. Several applications of these classes of matrices can be found in the literature. We develop algorithms in order to compute { K , s + 1 } -potent matrices and { K , s + 1 } -potent linear combinations of { K , s + 1 } -potent matrices. In addition, some examples are presented in order to show the numerical performance of the method. © 2012 Elsevier B.V. All rights reserved.


Barton and McCombie first reported the radical deoxygenation of secondary alcohols in 1975.' This is a two-step process that involves conversion of an alcohol into a thiocarbonyl derivative, and then radical reaction (Scheme A). Since this time, the Barton-McCombie deoxygenation has become a widely used synthetic tool; the reaction is both mild (tolerant of functionality) and efficient. The history of the developments of the Barton-McCombie deoxygenation is outlined in Chapter 1. This chapter extends to describe variations of this reaction, and of particular interest is the radical carboxyarylation reaction (RCAR). The RCAR is a domino sequence, which results in the stereoselective 1,2-disubstitution of an unactivated carbon-carbon double bond. X radical reaction ROH ^ " o ' ^ S " " thiocarbonyl derivative Scheme A. Baron-McCombie radical deoxygenation. The Barton-McCombie deoxygenation of primary alcohol derivatives was initially reported as being problematic;' " however, these problems were overcome by the use of increased reaction temperature.^ To dale, attempts to deoxygenate these alcohol derivatives at lower temperatures has had limited success. In the present study we demonstrate that the efficient Barton-McCombie deoxygenation of primary alcohols is possible at temperatures as low as 0 °C, using triethylborane/air and tris(trimethylsilyl)silane (TTMSS) (Scheme B). These findings are described in Chapter 2. OAr TTIVISS, EtjB/aIr, ROH ^ * ' '•> => room temperature primary alcohol thionocarbonate derivative Scheme B. Improved conditions for the Baron-McCombie radical deoxygenation of primary alcohol derivatives. In Chapter 3 the versatility of the RCAR has been explored through it's application to the development of a general synthetic approach to xestoquinone, halenaquinone and related natural products. The approach used is illustrated in Scheme C, which clearly shows how the RCAR enables a highly convergent synthesis.


T. SUMMARY Adverse flow environments pose challenging design constraints in aircraft engine components and component interactions. Some examples of such flow environments are: steep pressure gradients, random and periodic unsteadiness, shock wave interactions and 3-D boundary layer separation. These adverse flow environments and interactions promote the growth of various kinds of instability waves inherent in gas turbine engines, e.g., vorticity wave, entropy wave and acoustic or pressure wave instabilities. A series of smart subsonic and supersonic flow controllers are presented with applications to the design of aircraft gas turbine engine components. They are on-demand vortex generators capable of injecting co- and counter-rotating streamwise vortices in subsonic, transonic and supersonic flow. The strength and location of the vortex is a control variable and must be optimized via a closed-loop control algorithm. The subsonic smart VG assumes a ramp-type geometry (similar to Wheeler vortex generators) and the smart supersonic VG is a tailored cavity with a movable flap concealing the cavity. The movable flap is actuated inward to expose the cavity to transonic or supersonic flow. The depth of the cavity is controlled via a closed-loop feedback control system which ties the strength of the vortex to the desired performance as measured by one or more sensors. Candidate cost functions are proposed in the optimization routine for each component in a gas turbine engine.


The utility model relates to a band-type brake elevator traction machine with a mechanical buffering device, comprising a traction machine body, a brake, a brake arm and a band-type brake. The band-type brake elevator traction machine with the mechanical buffering device is characterized in that: a mechanical buffering device is arranged on the traction machine and comprises a piston cylinder, a piston and a piston rod which are correspondingly matched to work, the piston cylinder is provided with a sealing end cover and an oil adjusting and supplementing mechanism and is full of oil in the cylinder body, an oil through hole is arranged on the piston, and an oil through hole adjusting mechanism is arranged based on the oil through hole, therefore, oil can flow at two sides of the piston, and oil flow rate control in unit time is realized by adjusting the size of the oil through hole, the outer extending end of the piston rod is provided with a piston rod distance adjusting unit which can be driven by the brake arm, therefore, the piston rod is driven to slide by the movement of the brake arm. The braking noise can be safely and reliably reduced by the band-type brake elevator traction machine with the mechanical buffering device, the structure is simple and the application effect is good.


Objective:To improve work efficiency by optimizing the working process of the operating theatre.Methods:The working process of the operating theatre was reengineered,such as making standard,improving system,optimizing process and clarifying responsibilities.Satisfaction of patients,surgeons and nurses was analyzed before and after process reengineering.Results:Significant differences existed in the average waiting time of the operating patients,number of surgeries every operating room per day,interval between two consecutive operations before and after the process reengineering(P 0.01).Satisfaction of patients,surgeons as well as nurses were increased(P 0.01).Conclusion:Process reengineering improves work efficiency,minimizes cost and maximizes efficiency of the operating theatre.


The epicentre of the global HIV epidemic is southern Africa. Previous explanations point to migration patterns and highly skewed income distribution, both thought to promote risky sexual behaviour. This study emphasizes the importance of common infectious and parasitic diseases that increase the likelihood of HIV transmission by increasing contagiousness and vulnerability to infection. Using multiple regression analysis on country-level data, the authors find that socio-economic variables explain statistically only one-tenth of the difference in HIV prevalence between southern Africa and other low- and middle-income countries. Measures of five cofactor infections together with the socio-economic variables, however, explain statistically about two-thirds of the southern Africa difference in HIV prevalence. They conclude that the relative affluence of countries in southern Africa and historical migration patterns have tended to mask the vulnerability of the majority of their populations who are poor and who have very high prevalence of infectious and parasitic diseases. Those diseases replicate a cycle of poverty that produces biological vulnerability through coinfections. An important implication of this research is that integrating treatment of endemic diseases with other HIV-prevention policies may be necessary to slow the spread of HIV.


In this paper we present an overview on the development of a large vocabulary continuous speech recognition (LVCSR) system for Khmer, the official language of Cambodia, spoken by more than 15 million people. As an under-resourced language, develop a LVCSR system for Khmer is a challenging task. We describe our methodologies for quick language data collection and processing for language modeling and acoustic modeling. For language modeling, we investigate the use of word and sub-word as basic modeling unit in order to see the potential of sub-word units in the case of unsegmented language like Khmer. Grapheme-based acoustic modeling is used to quickly build our Khmer language acoustic model. Furthermore, the approaches and tools used for the development of our system are documented and made publicly available on the web. We hope this will contribute to accelerate the development of LVCSR system for a new language, especially for under-resource languages of developing countries where resources and expertise are limited.


Purpose: The purpose of this study was to identify the affecting factors on the health promoting behaviors of the clinical nurses. Methods: This study was a trans-sectional survey research. The subjects of this study were 206 clinical nurses. The data were collected by questionnaires and medical records. Results: There were significant positive relationships between health promoting behavior and perceived health status, job satisfaction, familial support. There were significant negative relationships between health promoting behavior and depression. The significant affecting factors on the health promoting behaviors of the clinical nurses were depression, familial support and job satisfaction. These 3 factors explain 18.6% of the health promoting behaviors of the clinical nurses. Conclusion: This study provides the empirical evidence that health promoting behaviors of the clinical nurses are closely related to depression, familial support, and job satisfaction. This results can be used to develop health promoting program for clinical staff nurses.


As the scale‐down and power‐saving of silicon‐based channel materials approach the limit, oxide semiconductors are being actively researched for applications in 3D back‐end‐of‐line integration. For these applications, it is necessary to develop stable oxide semiconductors with electrical properties similar to those of Si. Herein, a single‐crystal‐like indium–gallium–zinc–oxide (IGZO) layer (referred to as a pseudo‐single‐crystal) is synthesized using plasma‐enhanced atomic layer deposition and fabricated stable IGZO transistors with an ultra‐high mobility of over 100 cm2 Vs−1. To acquire high‐quality atomic layer deposition‐processed IGZO layers, the plasma power of the reactant is controlled as an effective processing parameter by evaluating and understanding the effect of the chemical reaction of the precursors on the behavior of the residual hydrogen, carbon, and oxygen in the as‐deposited films. Based on these insights, this study found that there is a critical relationship between the optimal plasma reaction energy, superior electrical performance, and device stability.


The excitatory amino acid transporters (EAATs) are transmembrane proteins responsible for the uptake of (S)-glutamate from the synaptic cleft. To date, five subtypes EAAT1−5 have been identified for which selective inhibitors have been discovered for EAAT1 and EAAT2. By screening of a commercially available compound library consisting of 4,000 compounds, N-acyl-N-phenylpiperazine analog (±)-exo-1 was identified to be a non-selective inhibitor at EAAT1−3 displaying IC50 values in the mid-micromolar range (10 μM, 40 μM and 30 μM at EAAT1, 2 and 3, respectively). Subsequently, we designed and synthesized a series of analogs to explore the structure-activityrelationship of this scaffold in the search for analogs characterized by increased inhibitory potency and/or EAAT subtype selectivity. Despite extensive efforts, all analogs of (±)-exo-1 proved to be either inactive or to have least 3-fold lower inhibitory potency than the lead, and furthermore none of the active analogs displayed selectivity for a particular subtype amongst the EAAT1−3. On the basis of our findings, we speculate that (±)-exo-1 binds to a recess (deepening) on the EAAT proteins than a well-defined pocket.


In this paper, a new method for 3D surface reconstruction of the brain is presented. The approach is based on the level set method. The 3D visual surface of the brain can be displayed accurately and quickly. Different with 3D model from MC (marching-cubes) algorithm, the results from the proposed method has many specific characteristics, such as direct, convenient and transparent.


This is a timely book on an important topic. Tibet has for long been a target of media and scholarly interest in the West. More recently, Xinjiang, in China's far north-west and home to the Muslim-...


In first year engineering courses, students possess a wide range of academic preparation such as their exposure to various mathematics courses and pre-engineering programs. Additionally, students bring perceptions about their abilities, and have already begun practicing preferred methods of analysis and documentation. Understanding how students with different backgrounds develop problem solving skills in first year engineering programs is of critical importance in order to close achievement gaps between diverse populations. This study examines how students solve engineering problems and identifies variations based on student factors of gender, ethnicity, mathematics preparation and achievement, and prior engineering experience. Solutions for three problems from 27 students were analyzed (n = 68 solutions). Students worked out problems using custom-designed software that digitally records ink strokes and allows researchers to associate codes to the problem solution at any point, even in portions of the problem solution that would not have been available without the use of this technology, such as in erased work. Differences in how students solve problems were assessed based on the prevalence (or absence) of elements and errors in the problem solving process, which were evaluated using task analysis. Results indicated that pre-engineering experience did not have a significant impact on successfully solving problems; however, having completed a calculus course was significantly related to successful problem solving. Future research will expand the study population to a larger sample of first year engineering students across multiple semesters, identifying key strategies that are absent for students with low mathematics preparation, and to investigate relationships between prior academic preparation and indicators of metacognition.


Abstract Disclosure: S. Kregel: None. Background: There exists a tremendous need for establishing prostate cancer (PCa) murine models capable of recapitulating the progress of human PCa. By itself, the murine prostate does not form sporadic tumors and is anatomically and developmentally different from the human prostate. Engineered mouse models, however, lack the heterogeneity of human disease, are often driven in a contrived manner, and rarely (if ever) establish metastatic growth. Human xenografts represent an alternative, but they rely on tumor growth in an immunocompromised host, thus preventing the study of tumor-immune interactions and immunotherapies. Accordingly, we generated PCa xenograft models in a murine system with an intact human immune system (huNOG mice) to test the hypothesis that humanizing tumor-immune interactions would improve modeling of metastatic PCa as well as our ability to model the impact of hormonal and immunotherapies. Methods: Male huNOG and huNOG-EXL mice were produced at Taconic Biosciences by engrafting juvenile NOG mice with human CD34+ hematopoietic stem cells. These mice stably maintained multiple human cell lineages, including functional human T-cells. We utilized two human PCa xenograft cell line models transduced with luciferase to assay organ-specific metastatic growth. First, castrated and intact control mice were injected subcutaneously with 22Rv1 cells. When tumors reached >100 mm3, half of the castrated mice were treated with enzalutamide (enza), and tumor growth was then monitored to endpoint. Additionally, VCaP tumor-bearing mice were castrated when the tumors reached ∼200 mm3, and once the tumor grew back, they were randomized and treated with enza and/or the anti-PD-1 antibody, pembrolizumab (pembro) as well as with vehicle controls. At sacrifice, organs were ex vivo analyzed for metastatic growth, tumor infiltrating lymphocytes, and splenic immune reconstitution. Results: In 22Rv1 tumor-bearing mice, subcutaneous tumor size was not significantly altered across conditions. However, the extent and growth at the secondary sites differed markedly in castrate huNOG vs conventional NOG mice treated with enza. VCaP xenograft tumors showed marked decreases in growth with enza and pembro treatments in huNOG mice, while no effect was observed with either of these treatments in NOG mice. Furthermore, immune responses to enza treatment in huNOG and NOG mice were distinct, as enza treatment only increased intra-tumor CD3+ T-cells as well as CD3+ T-cell activation in huNOG mice. Conclusions: These results illustrate, to the best of our knowledge, the first model of human PCa that metastasizes to clinically relevant locations, has an intact human immune system, and responds to standard-of-care hormonal therapies in a manner similar to responses observed under clinical settings. Presentation: Thursday, June 15, 2023


The study of red spinach antioxidants (Blitum rubrum) in two types of solvents i.e ethanol and water has been performed. The purpose of this study was to determine the antioxidant activity of red spinach extract from Tinombo Selatan district, Central Sulawesi. Red spinach was macerated in ethanol and water to obtain variations of extract concentrations of 20, 40, 60, and 80 mg/L. Free radicals used were DPPH reagents while vitamin C was used as a positive control. The measurement of absorbance of red spinach's extract was conducted by spectrophotometric. The results showed that IC50 extract of red spinach in ethanol and water were 51.404 mg/L and 52.227 mg/L, while the value of IC50 vitamin C in ethanol and water solvent was 43.241 mg/L and 140.507 mg/L. Based on the IC50 red spinach's extract in ethanol and water have strong antioxidant activity.


Abstract : To realize the advantages of Computer Integrated Manufacturing (CIM), faster and more effective inspection and control systems are required than can be provided manually. Inspection and control systems that use sensors, detectors and data entry stations to monitor conditions and detect variations in material flow. process parameters and product quality need to be considered as well as controllers that are capable of determining real time corrective action. In this project the configuration of the CRAMTD Demo plant and the architecture of information flow was laid out and a strategy was developed that could accommodate present and future management information needs. The MRE production line was selected to demonstrate the use of these advanced control strategies and seven areas of quality control were addressed. While a strategy was developed to support Level 2 and Level 3 CIM the implementation of sensors and quality control strategies was completed at Level 2 CIM. It is recommended that a follow-on project complete Level 3 CIM according to the SP-88 model


China Dream,as a significant strategic thought about the formation of a new session of the CCPC and a political declaration of the future development of the Party and the state,is the inheritance and innovation of the Scientific Outlook on Development,the Sinicization of Marxism,and the latest achievement of the theoretical system of socialism with Chinese characteristics.It is the development of Marxism in contemporary China at the new stage,having distinctive theoretical qualities such as lead,time and history.


In this paper, we investigate network nest coded modulation schemes for multiple access relay channels. The performance of the distributed systems which are based on distributed convolutional codes with network coded modulation is presented. An analytical upper bound on bit error probability performance for the studied distributed systems with Maximum Likelihood Sequence Detection (MLSD) is derived. The constructured bounds for the investigated systems are shown to be asymptotically tight for increasing channel Signal-to-Noise Ratio (SNR) values


This paper introduces the requirements that must be met to design a general and eecient control architecture for robotics system. The proposed solutions to these essential requisites are detailed and illustrated in the context of the development of the Inria three-level open architecture. The stress is put on the use of formal methods at all possible levels. In the process of creating a robot controller, it is often required to rely on diierent tools such as: matrix calculations and computer algebra, simulators and modelers, discrete systems and automata, code generators for automatic code downloading... These tools intervene in the various phases of the development of the controller: modd eling, algorithm design, development of software and hardware, simulation, validation, installation and operation. Today, these diierent steps require diierent formalisms bee tween which translations are unfortunately often performed by hand. Available tools typically focus on one or few techniques. It is of signiicant interest to have within integrated environments diierent tools communicating with no need for manual connection, that permit to implement methh ods based on well deened concepts. The architecture's job is to provide those tools to allow various persons to interact with and modify the robot controller independently while hiding the implementation details required to follow the identiied methods and the underlying concepts. This work strives towards the development of an integrated cace (Computer Aided Control Engineering) tool that implements a general conn trol scheme with automatic target code generation. It is based on the methods and concepts that will ensure the existence of expressive formalisms amenable to syntacc tic transforms while preserving semantic equivalence. Also, the control of mechanical systems requires to take into account the dynamics during the overall development process. This suggests a hierarchy-like decomposition with decisional, control and functional levels. Each level has a given range of operation and provides an appropriate summ mary to the others to help the nal integration. This three-level control architecture increases the degrees of abstraction while decreasing the frequency of interaction with the environment. But, this vertical decomposition must not aaect the on timee ree sponse of the lowest levels of the systems which must jointly handle the discrete and continuous worlds caracterizing this typical example of hybrid system. Therefore, a proper formalism to describe and handle adequate abstractions must be available at each level in order to enforce a methodology of speciication independent of the implementation phase. To help …


The present invention relates to an ink loader, capable of identifying characteristics on the solid ink stick is placed in the ink in the ink stick loader support member. Ink loader includes two light sources, two light sources is configured toward the solid ink stick to different surfaces of the scattered light emission. Two sets of optical sensors positioned to receive the corresponding identification features from the solid ink stick reflected light (if present). The controller receives signals generated by these two sets of optical sensors, and the reference signal from the sensor to identify an ink stick.


The characters of low carbon city have been summarized by this article.The benchmarks and its index system of low carbonalization and sustainable development in cities have been pointed out in this paper.The idea of low carbonalizition has been considered in the process of sustainable development in cities of China,which is based on the study of sustainable development in the world and that in China.


One of the physiological basis of acupuncture is the somatosensory input on the autonomic nervous system function. Furthermore physical therapy is done a clinical application on activating and inhibiting by such as brushing to skin. The purpose of this study is evaluating the effect of autonomic response to "acupuncture", "tube", "brushing". It measures the electrocardiogram, blood pressure, body flexibility on 20 healthy men (18-21 years old). Acupuncture is the stimuli to cutaneous tissue. Tube is done tapping at the top of the tube to skin. Brushing is done about 5800/minutes by the motor to skin. Autonomic nervous system is assessed by heart rate variability. The high-frequency component (HF: 0.15-0.5 Hz) reflects vagal activity, while the low-frequency component (LF: 0.04-0.15 Hz) reflects both vagal activity and cardiac sympathetic activity. HF was used as an index of parasympathetic activity, and LF/HF was an index of sympathetic activity. The first experimental procedure is as follows, 1) resting supine 5 minutes, 2) deep breathing 5 times, 3) rest supine 3 minutes, 4) standing 3 minutes, 5) deep breath 5 times. It observes the suppression state of parasympathetic function. The second experiment procedure is as follows, 1) twice the body flexibility, 2) blood pressure, 3) resting sitting position 3 minutes, 4) each stimulus of acupuncture, tube, brushing, 5) blood pressure measurement after 3 minutes, 6) twice the body flexibility measurement. Parasympathetic nervous function after each stimulus has significantly increased.


The article considers the semantics of space formed by the system of object-details and sonosphearic elements in the finale part of Anton Chekhov's The Cherry Orchard. The theatrical version of the play created at the Moscow State Theater "Lenkom" (dir. Mark Zakharov) became a starting point for the analysis of the literary text. Detail is studied as regards the formation of motifs involved in constructing the spatial organization of the artistic world, as well as an element of the material world that constructs a space in a certain way. Such characteristics of place as narrowness, length, isolation, "verticalization" or 'horizontalization", as well as the properties of its boundaries create a semantic field for the world of objects and things, in which Firs finds himself at the end of the play. The contextual analysis of the world of things makes it possible to identify the role of certain characteristics in the topos of the house and estate, the semantics of their transformation, and to assess the role of details in creating the meanings associated with the ontological sphere and its change and in unfolding that meaning in the character and the reader (spectator)'s minds. The significance of the transformation of the place in the final scene makes it possible to trace the connection between the inner state of the character and the "state" of the house itself and read the play's final scene in terms of the connection between man and place.


To determine the epidemiology and impact of co-infection on COVID-19 pneumonia in critical care setting.

 This was a single center- retrospective study of COVID-19 patients, who were admitted to intensive care unit between March 2020-April 2021. Only patients with microbiological evaluation of blood, respiratory, or urine culture data were included. Community onset bacterial co-infection (COI) was defined as infection diagnosed within 48 hours and hospital acquired bacterial infection (HAI) after 48 hours of hospital admission. Both COI and HAI were further categorized into respiratory, blood or urinary sources. Demographics, laboratory and hospitalization outcomes were compared between patients with and without COI and HAI.

 Among the 141 patients, COI was found in 25/132 patients (19%) and HAI in 41/109 patients (38%). COI was associated with younger age, lower body mass index (BMI) and being from nursing or long- term care facility. HAI was associated with longer length of hospital stay (29 vs 15 days). Staphylococcus aureus pneumonia (31.3%) and Pseudomonas aeruginosa pneumonia (40.0%) were the most common cause of COI and HAI respectively. Overall, gram negative bacteria predominated in both community and hospital acquired pneumonia. Candida was the single most common cause of blood stream infection in HAI (23%). The hospital survival was not significantly different with or without COI.

 In the critical care setting, a significant proportion of patients with COVID-19 had COI and HAI, especially patients from nursing or long-term care facility. Antibiotic coverage for COI and HAI pneumonia should account for the increase in prevalence of Staphylococcus aureus and Pseudomonas aeruginosa respectively.


The considerable number of bilateral investment treaties (BITs) in force has given rise to conflicts when, in relation to the same subject matter, a right of action exits for a given investor (or related investors) under different BITs. In fact, two recent international disputes, the CME v. Czech Republic and Lauder v. Czech Republic arbitrations, have attracted widespread attention as the first example in which this situation has arisen. The same acts by the Czech Republic were subject to two separate arbitrations conducted concurrently. The two cases, however, underwent conflicting procedures, were dealt with under conflicting governing treaty provisions and resulted in seemingly conflicting awards. This situation has highlighted the risks inherent in the current international investment regime of intricate, non-coordinated networks of BITs. The fundamental risk is that this glaring inconsistency could potentially bring a backlash against international investment. On the other hand, the speedy completion of all litigation in the Czech cases (including full payment by the State concerned), notwithstanding these complexities, indicates that international commercial arbitration (rather than institutional frameworks providing for remedies such as consolidation of proceedings) may effectively resolve disputes, with full respect given to substantive law and due process. The CME/Lauder v. Czech Republic arbitrations were possibly the first publicly known disputes under a BIT decided through international commercial arbitration proceedings in accordance with the UNCITRAL rules instead of within the International Centre for Settlement of Investment Disputes (ICSID). The national courts of the country where the award was rendered, Sweden, had to rule on the challenge, brought in accordance with the local arbitration statute, by the losing State, in which the Czech Republic argued to set aside the awards based on the alleged conflict of the two proceedings and resulting awards. This Essay considers the implications of these proceedings and subsequent judicial rulings.


In artificial pools Gambusia affinis greatly reduced rotifer, crustacean, and insect populations and thus permitted extraordinary development of phytoplankton populations (2x108 cells per milliliter). Other effects included decreased optical transmissivity and increased temperature of the water, decreased amounts of dissolved inorganic phosphorus, and increased amounts of dissolved organic phosphorus, inhibition of Spirogyra, and replacement of one annelid, Chaetogaster, by another, Aeolosoma.


Condensation reactions of comenaldehyde methyl ether (I) with malonic acid, ethyl cyanoacetate, and cyanoacetamide to give β-(5-methoxy-4H-pyran-4-on-2-yl)acrylic acid (II), ethyl 2-cyano-3-(5-methoxy-4H-pyran-4-on-2-yl)propenoate (III), and 2-cyano-3-(5-methoxy-4H-pyran-4-on-2-yl)propenamide (IV), respectively, are described. Ultraviolet absorption spectra for 2-hydroxymethyl-5-methoxy-4H-pyran-4-one, I and II are presented.


Summary This pilot study aims to identify the presence of components which are consistent with meaningful learning in science teaching. Semi-structured interviews were conducted with six science teachers and the results show that some of the teachers' perceptions and practices in science teaching are consistent with meaningful learning components. Science teachers' descriptions led to the identification of six categories which can be classified into two sets of components: Constitutive (e.g., 'authenticity' and 'prior knowledge') and. Consecutive (e.g., 'cooperative learning', 'knowledge construction', 'learning by doing' and 'feedback'). Based on these results, it can be concluded that there is a positive change in teachers' perceptions and implementation of pedagogical processes for promoting meaningful learning in science teaching. The implications of these findings for future research are discussed.


A model of a thermal transistor to control heat flow is reported. Like its electronic counterpart, the thermal transistor is a three-terminal device with the important feature that the heat current through two terminals can be switched or modulated by the temperature of the third terminal. The thermal transistor model is possible because of the negative differential thermal resistance.


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A 63-year-old woman with newly diagnosed low-grade follicular lymphoma underwent a bone marrow biopsy for staging before treatment. Family history was unremarkable. She presented with borderline red cell index (red blood cells [RBCs], 3.49 × 106/μL; hemoglobin, 11.7 g/dL) and


Background and Purpose—Conjugate eye deviation (CED) occurs frequently in patients with acute stroke. The purpose of this study was to elucidate the factors that correlate with CED as well as the relationship between CED and outcomes in patients with acute intracerebral hemorrhage. Methods—A total of 211 patients with acute supratentorial intracerebral hemorrhage were recruited in a multicenter, prospective study. CED was assessed with a National Institutes of Health Stroke Scale "best gaze" subscore of ≥1. Hematoma location and volume were assessed on CT. Results—Forty-five percent of the patients had CED. On multivariable analysis, right-sided lesion (OR, 2.36; 95% CI, 1.18–4.93), hematoma volume (OR, 1.07; 95% CI, 1.04–1.10 per 1 mL), and baseline Glasgow Coma Scale score (OR, 0.66; 95% CI, 0.53–0.80 per 1 point) were independently associated with CED. After adjusting for sex, age, intraventricular extension of the hematoma, baseline Glasgow Coma Scale score, and hematoma volume, the presence of CED bo...


International education is a vast field of scholarship and practice. Internationalization of higher education (IHE) has been contested, debated, deconstructed, and reconstructed. While some have discussed the end of internationalization (Brandenburg & De Wit, 2011), others have discussed reimagining or rebuilding this field of practice (Stein, 2021). Since the post-World War II era, the international education sector has faced many challenges including the Cold War, 9/11 and its responses, the election of Donald Trump, and Brexit, but perhaps nothing compares to COVID-19. The pandemic has severely impacted the core of the internationalization of higher education – human mobility. CISN reached out to three IHE scholars and leading practitioners in the USA and Canada to learn about their visions for the future of IHE in the "post-pandemic" landscape. We encourage readers to send us their comments about their own responses to the following questions and their thoughts on the responses from Dr. Sonja Knutson, Dr. Harvey Charles, and Dr. Adel El Zaïm outlined here.


Throughout history, the resistant structure of bridges has been defined by their longitudinal dimension. The presence of two free boundaries requiers the transfer of the load to the supports in this direction. The paper presents a series of functional and geometrical conditions which determine the spatial quality of structure.


Transparent linear NIR digital graphics with the intention of security information were printed on a polypropylene material. A label for expensive juices in transparent glass or plastic packaging is demonstrated. Obligatory information about the contents of the liquid was made to be read with the naked eye. The "Z" (near-infrared) information is expanded with data integrated for joint digital printing. This data does not disrupt the original, planned visual appearance of the label, "V" (visible). Although the two graphics are in the same place, the IR graphics on the label cannot be discerned with the naked eye. This brings elements of secrecy and protection against attempts to counterfeit the contents of the transparent packaging. The separation and recognition of the two pieces of information, V and Z, are achieved with a security camera in the near-infrared mode or with one of the many NIR detectors that surround us. In the article, the "VZ" algorithm for the integration of two independent graphics and the limitations set by digital printing are published. Toner properties and the method for developing the recipes for the composition of twin colorants for two spectral ranges are presented using spectroscopy.


The paper is based on the Bachelor Thesis defended this year in ITEP, Moscow. This is the extended version of [arXiv:1707.02242] and contains a lot more technical details of the calculations. We consider (1+1)-dimensional massless scalar field theory with Dirichlet boundary conditions on arbitrary time-like curve. It is well known that in this situation there is a non-zero energy flux at the tree-level, if the latter curve corresponds to a non--stationary motion of the boundary. Such a problem is usually referred to as the radiation due to moving mirrors. We calculate quantum loop corrections to the energy flux from moving mirrors and find that they grow with time. Hence, they are not suppressed in comparison with the semi--classical contributions. Thus, we observe the break down of the perturbation theory, discuss its physical origin and ways to deal with such a situation.


Cigarette smoking is the single largest cause of chronic obstructive pulmonary disease in the developed world and is preventable. Of those with COPD symptoms, half may not be aware they have the condition and be na ve to treatment.


Conventional direct surface mining techniques offer low-cost extraction of shallow-lying oil fields. Provided that the costs of separation of the hydrocarbons from the host rock and the mitigation of the environmental impacts can be brought within acceptable limits, these methods appear capable of making a rapid contribution to the nation's oil supply at prices not too far removed from present levels. Several specific research projects have been identified which would materially advance the likelihood of such prospects being viewed favorably by mining investors. The basic need is in the area of estimation of mineable reserves. A similar lack exists in the level of knowledge of physical reservoir rock properties. The main additional research requirement is in the possibility of recovery of some of the immense resource that lies beyond the reach of existing production technology, and appears also to bring into consideration large volume of hydrocarbons whose existence is either known or suspected, but which have never been considered as a producible reserve.


The present invention relates to a vacuum dewatering device for the sludge. The present invention is found in the slurry feed that waste water having a sludge supply, rotation of the hollow fixed to two opposite sides of Article slurry supply supporting shaft and on the outer periphery a plurality of annular form in the circumferential direction of the first constant-through holes with having a guide groove spacing a plurality of strip the second guide groove the shaft in two rotation support consists of a support drum body is rotated in the axial suction portion of the drum body is immersed in the waste water drum, is separated from the suction drum rotating drive roller, and the adsorption is by having the direction having the filtering belt, is connected to the rotation support shafts at both ends in the receiver tank, the suction drum is a predetermined negative pressure takes connected to the respective rotation support shaft of the suction drum on the inside and the inlet is immersed in the waste water absorption passage connecting the drum and the drive roller and a sealing cover that by shielding the non-contact portion of the filter belt and a suction drum in the vacuum pipe, the suction drum which is divided into a waste water and the intake passage are separated from , And a scraper to remove the dewatered sludge cake is in close contact with the outer surface of the filtering belt drive roller side. The present invention is increased, both the water absorption of from sludge adsorption rate and the adsorption sludge from sewage can be improved, the overall dehydration efficiency, it is possible to make it sure to remove the sludge from the filter belt is also minimal clogging phenomenon of the filter belt by the sludge.


The Savannah River Site (SRS) was proposed as one of eleven potential sites to be included in the U.S. Department of Energy Programmatic Environmental Impact Statement (PEIS) for the Global Nuclear Energy Partnership (GNEP) program. The approach to meet siting and infrastructure requirements for possible GNEP facilities at the SRS focused on available infrastructure including land, cooling water systems, high voltage power supplies, existing heavy haul roadways, existing analytical capabilities, and existing waste handling capabilities. Additional siting criteria and existing SRS capabilities and conditions were developed to locate the GNEP within a commercial Energy Park contained within, but separate from, the SRS. Included as part of, or corollary to, existing infrastructure at the SRS was the availability of a nuclear trained workforce living within the area. The SRS consists of approximately 803 square kilometers (310 square miles) in the Upper Atlantic Coastal Plain of South Carolina bordering along the Savannah River. Historic production reactors, processing, and laboratory facilities are currently being decommissioned and destroyed while new facilities such as the MOX facility are being built. Existing legacy infrastructure, beneficial to the potential GNEP facilities, continues to exist and operate. The SRS has a long history of processing, reprocessing and inmore » the disposition of nuclear fuels and byproducts continuing through today with HCanyon as the only DOE facility currently capable of uranium reprocessing. Because of ongoing operations and maintenance of historic systems, SRS has existing infrastructure immediately available for GNEP facilities in or near the proposed Energy Park. The Energy Park location was chosen to achieve maximum use of this legacy infrastructure. In summary: Requirements for potential or conceivable GNEP facilities can be met using the existing facilities and infrastructure of the SRS. A potential commercially operated Energy Park located within the existing boundaries of the SRS can use existing site infrastructure to lessen the overall construction costs and decrease the start up time for our national GNEP program. (authors)« less


Both intensity and adherence to lipid lowering therapies (LLT) play an important role in effectiveness of the therapies in patients at risk for cardiovascular events.

 To evaluate the association of adherence and treatment intensity with cardiovascular outcomes and all-cause mortality in very high-risk patients (as defined by the current ESC guidelines) treated with statin and/or ezetimibe.

 Retrospective cohort study was based on German health claims data (2010–2015) obtained from German Institute for Health Research (InGef) database and included patients ≥18 years with an initial LLT treatment (statin and/or ezetimibe) in 2011–2013, and diagnoses of cardiovascular disease (CVD), stage 4 or 5 chronic kidney disease (CKD) or type 2 diabetes mellitus (DM). Patients must have had at least 2 LLT prescriptions in the first year to ensure intention of treatment. Follow-up period started 1 year after the second LLT prescription and continued until one of the events of the composite study endpoint (hospitalisation for myocardial infarction, unstable angina, ischemic stroke, heart failure, revascularization, or all-cause death) or 31.12.2015, whichever occurred earlier. Adherence was measured annually by the proportion of days covered (PDC) using prescription data. Treatment intensity was quantified based on expected LDL-C reduction as described in the American College of Cardiology and American Heart Association (ACC/AHA) 2018 guidelines. Adherence and treatment intensity were multiplied to create a combined measure of intensity after accounting for adherence.

 73,257 patients of the CVD cohort were 68 (SD=12) years old, 59% men; the DM cohort (no CVD) had 13,584 patients, age 64 (10), 47% men; 472 patients in the CKD cohort (no CVD) were 65 (15) years old, 46% men. In a Cox proportional hazards model, each 10% increase in treatment intensity (LDL-C lowering) was associated with 18% lower risk of CV event in the CVD (HR 0.82, 95% CI 0.82–0.83), 21% - in the DM (HR 0.79, 95% CI 0.76–0.83), and 15% - in the CKD (HR 0.85, 95% CI 0.75–0.97) cohorts. Similarly, each 10% increase in adherence (PDC) was associated with 6% lower risk of CV event in the CVD (HR 0.94, 95% CI 0.93–0.94), 7% - in the DM (HR 0.93, 95% CI 0.91–0.94), and 7% - in the CKD (HR 0.93, 95% CI 0.89–0.97) cohorts. Each 10% increase in adherence-adjusted intensity was associated with 16% lower risk of CV event in the CVD (HR 0.84, 95% CI 0.83 - 0.85), 19% - in the DM (HR 0.81, 95% CI 0.78–0.85), and 17% - in the CKD (HR 0.83, 95% CI 0.72–0.96) cohorts. The models controlled for age, sex, Charlson comorbidity index and other cardiovascular risk factors at baseline.

 A higher adherence and/or treatment intensity of LLT was associated with significantly lower risk of CV outcomes or all-cause death in German very high-risk patients. Strategies to tailor intensity to patient profile and improve adherence could further lower risk of CV events.

 Amgen Europe GmbH


The high level of logistics development positively affects many socio-economic indicators of the country's economic development, such as inflation rates, productivity indicators, etc. Increasing productivity through the use of logistics at enterprises has a positive impact on the competitiveness in global markets, as well as on profit level. The aim of this article is to analyze the evolution of productivity in rail transport among several countries from 1997 to 2016. We use a non-parametric approach that allows us to change the performance and efficiency of the transport infrastructure. The main indicators of rail transport should be divided into variations of efficiency and technical changes. The results indicate that productivity growth is concentrated in the last period (1997-2016), when most countries conducted reform processes. This increase in productivity occurred mainly due to technical progress. We also analyze the correlation analysis to determine the factors most influencing the effectiveness. In contrast to similar articles, we justified that the higher the autonomy and financial independence, the higher the level of efficiency and technical change in the infrastructure of the railway transport.


To study the utility of 2D shear wave elastography (SWE) and ascertain cut‐off values of shear wave elasticity (SWe) to differentiate benign and malignant thickening of the gallbladder wall.


The main focus of my work has been the role of the MRN in the S-phase DNA damage checkpoint. The MRN plays many roles in cellular metabolism; some are checkpoint dependent and some are checkpoint independent. The multiple roles in cellular metabolism complicate study of the role of the MRN in the checkpoint. MRN mutations in budding yeast and mammals may display separation of function. Mechanistically, MRN, along with its cofactor Ctp1, is involved in 5' resection to create single stranded DNA that is required for both signaling and homologous recombination. However, it is unclear if resection is essential for all of the cellular functions of MRN. Therefore I have made mutations to mimic those in budding yeast and mammals. I found that several alleles of rad32, as well as ctp1Δ, are defective in double-strand break repair and most other functions of the complex but maintain an intact S-phase DNA damage checkpoint. Thus, the MRN S-phase checkpoint role is separate from its Ctp1and resection-dependent role in double-strand break repair. This observation leads me to conclude that other functions of MRN, possibly its role in replication fork metabolism, are required for S-phase DNA damage checkpoint function. One of the potential roles of Rad32 and the rest of the MRN complex is in sister chromatid exchange. The genetic requirements of sister chromatid exchange have been examined using unequal sister chromatid assays which only are able to assay exchanges that are illegitimate and produce changes in the genome. Most sister chromatid exchange must be equal to maintain genomic integrity and thus far there is no good assay for equal sister chromatid exchange. Yeast cells expressing the human equilibrative nucleoside


The main problems in designing embedded real-time system are discussed in the paper,including real-time goal analyzing,hardware platform designing,the choice of real-time operation system,the choice of programming language and some other problems.


This study was designed to evaluate the bacterial translocation (TB) from the
gastrointestinal tract to visceral organs in rats submitted to laparotomy and
common bile duct ligation (CBDL). Four groups of rats were studied: group I (n =
10) CBDL; group II (n=10) control or "sham operation"; group III (n= 12) CBDL
and 99mTc-E.coli and group IV (n=5) control or "sham operation" e 99mTc-E.coli.
All the animals were operated with aseptic technic under intraperitoneal
anesthesia with pentobarbital sodium (200mg/Kg). On 7th postoperative day the
animals of groups I and II were killed with a letal dosis of anesthetic and the liver,
spleen, mesenteric lynfonodes and lungs were ressecated to microbiological
(Agar-blood and Agar-Mac Conkey) and histological examination (H.E. and
Masson Trichromic) through morphometric analysis. On 7th postoperative day
the animals of III and IV groups were submitted to 99mTc-E.coli gavage and after
24 hr they were killed and their organs were ressected. After that, the bacterial
radioactivity was mensured through an Automatic count of Gama Radioative –
model ANSR (Abott Laboratories). The bilirrubin levels of the jaundiced rats were
elevated compared with the control groups. The incidence of bacterial
translocation was higher in group I compared with control group (p 0,05). The
results showed no significant differences among the jaundiced and control groups
to the liver and lungs. The data allow to conclude that in jaundiced rat with ligated
bile duct occurred bacterial translocation through microbiological analyses. The
model proposed showed no bacterial translocation by the labeled 99mTc technic.


The invention to be, the device relates to a device for the generation, distribution and / or the use of electrical energy comprises an electrical component arranged on the housing and the insulation space to surround the insulating area. The insulating space can contain an insulating dielectric gas containing an organic fluorine compound (A). The apparatus further comprises a molecular sieve and arranged to come into contact with the insulating gas. The molecular sieve has at least one larger average pore size than the molecular size of the degradation products of the above organic fluorine compound (A) generated during operation of the device. The adsorption capacity of the molecular sieve for the organic fluorine compound (A) is lower than for the at least one degradation product. According to the invention, the device further comprises at least one drying agent arranged to be in contact with the insulating gas.


Photoinduced scattering of light and low-intensity Rayleigh scattering in LiTaO3:Cr were observed. The photoinduced scattering was isotropic, indicating that the mechanism of recording of a noise holographic grating in a crystal was not related to the bulk photovoltaic effect or diffusion. Crystals of LiTaO3:Cr exhibited a strong photorefractive sensitivity amounting to 4×10−5cm3/J.


C1796 Immune Phenotyping and Efficacy of Low Dose ATG in NonSensitized Kidney Recipients Undergoing Early Steroid Withdrawal: A Randomized Pilot Study. B. Smith,1 M. Grafals,2 N. Murakami,1 A. Trabucco,2 K. Hamill,2 E. Marangos,2 H. Gilligan,2 J. Pomposelli,2 E. Pomfret,2 J. Azzi,1 N. Najafi an,1 L. Riella.1 1Transplantation Research Center, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA; 2Department of Transplant Surgery, Lahey Clinic Medical Center, Burlington. Rabbit antithymocyte globulin (ATG) is commonly used as an induction agent in renal transplant recipients, but the ideal dosage in tacrolimus-based early steroid withdrawal protocols has not been established. The purpose of this pilot study was to determine the safety and effi cacy of lower dose ATG as induction therapy in low immunological-risk kidney transplant recipients. In this prospective study, 45 patients were randomized (1:1) to our standard dose ATG (total dose of 3.75 mg/kg) (sATG) vs. lower dose of 2.25 mg/kg (lowATG). All patients received tacrolimus and mycophenolate mofetil and underwent early steroid withdrawal within 7 days. The primary end point was biopsy-proven acute rejection at 12 months. Prospective immune phenotyping of freshly isolated PBMCs was performed at baseline, 3, 6 and 12 months after transplantation. The rate of acute rejection was 17% and 10% in the sATG and lowATG, respectively. Analysis of PBMCs revealed equal depletion of CD4 and CD8 effector memory (CD45RO+CD62Llow) T cells at 3 months post-transplant in both ATG arms followed by similar recovery kinetics at 6 and 12 months post-transplant. In contrast, Treg/CD4effmem ratio peaked at 3 months with slightly higher trend in lowATG compared to sATG. No statistically signifi cant differences were found in graft survival, patient survival or infections between the two groups, though there was a trend towards more leukopenia(43% vs. 30%), CMV(8% vs. 0) and BK(4% vs. 0) infections in sATG group vs. lowATG. Recent thymic emigrants T cells (CD4+CD31+CD45RA+) were signifi cantly reduced in both groups post-transplant and had no correlation with the incidence of leukopenia. Lastly, a cost saving of ~US$3,000/patient was seen with lowATG. In sum, in low immunological risk kidney recipients undergoing steroid withdrawal, low dose ATG seems to be safe and effi cacious in preventing acute rejection with potentially lower infectious complications and cost savings. Abstract# C1797 Transition From Dosing Rabbit Antithymocyte Globulin Using Total Body Weight to Adjusted Body Weight Preserves Excellent Outcomes in Obese Renal Transplant Patients. M. Hurrell, W. Ally, C. Eymard, D. Keith, K. Brayman, A. Agarwal. University of Virginia Health System, Charlottesville, VA. Background: The dosing weight utilized to calculate rabbit antithymocyte globulin (ATG) doses for renal transplantation varies according to transplant center and includes ideal body weight, total body weight (TBW) and adjusted body weight (ABW). However, there is limited literature regarding the optimal dosing weight of ATG in obese patients. This study aims to evaluate graft outcomes associated with the use of ABW as compared to TBW in renal transplant patients. Methods: This is a retrospective single center study of adult obese (BMI ≥ 30) solitary renal transplant patients from 2011 to 2013. All patients received either 4.5 mg/kg ATG C1797 Transition From Dosing Rabbit Antithymocyte Globulin Using Total Body Weight to Adjusted Body Weight Preserves Excellent Outcomes in Obese Renal Transplant Patients. M. Hurrell, W. Ally, C. Eymard, D. Keith, K. Brayman, A. Agarwal. University of Virginia Health System, Charlottesville, VA. Background: The dosing weight utilized to calculate rabbit antithymocyte globulin (ATG) doses for renal transplantation varies according to transplant center and includes ideal body weight, total body weight (TBW) and adjusted body weight (ABW). However, there is limited literature regarding the optimal dosing weight of ATG in obese patients. This study aims to evaluate graft outcomes associated with the use of ABW as compared to TBW in renal transplant patients. Methods: This is a retrospective single center study of adult obese (BMI ≥ 30) solitary renal transplant patients from 2011 to 2013. All patients received either 4.5 mg/kg ATG for immediate graft function or 6 mg/kg for delayed graft function (DGF) based on respective dosing weight. One year actuarial patient and graft survival, renal function, and prevalence of rejection were reported. Univariate analysis was performed and p<0.05 was consider signifi cant. Results: 41 obese patients underwent renal transplantation: 28 in the TBW group and 13 in the ABW group. One year patient survival (TBW: 96% vs. ABW: 100; p=ns) and graft survival (96% vs. 100; p=ns) was comparable. Baseline demographics were similar between groups, including BMI (34.1±2.6 vs. 34.1±3.0; p=ns), % patients morbidly obese (BMI >35) (32% vs.38; p=ns), and % patients with DGF (14.3% vs. 38.5; p=ns). The TBW group received more ATG per patient as compared to the ABW group (542±102 mg vs. 430 mg±102, p<0.05) or a 21% reduction in total usage. This represents a decreased cost of $1,388 per patient ($10,789± 3,663 vs. 9,401±2,246; p<0.05). No difference in renal function, as determined by estimated glomerular fi ltration rate, was observed between groups at 3, 6, and 12 months post-transplantation (59±16 ml/min/1.73m2 vs. 57±20; p=ns, 60±19 vs. 56±19; p=ns, 57±22 vs. 51±18; p=ns). Rates of acute rejection were similar between the two groups at 3 and 6 months respectively (21.4% vs. 14.3%; p=ns and 21.4% vs. 15.4%; p=ns). Conclusions: These data suggest that ABW may be safely used to dose ATG while improving value of care through a 21% reduction in ATG usage. Utilizing ABW to dose ATG maintains excellent clinical outcomes with comparable rates of rejection in obese renal transplant patients. Abstract# C1798 Immunoglobulin Induction Therapy in Renal Transplant Recipients Five Year Data of a Prospective Randomized Pilot Study. R. Weimer,1 B. Bartylak,1 A. Staak,1 F. Renner,1 C. Suesal,2 H. Dietrich,1 L. Rainer,1 W. Padberg,3 G. Opelz.2 1Department of Internal Medicine, University of Giessen, Giessen, Germany; 2Institute of Immunology, University of Heidelberg, Heidelberg, Germany; 3Department of Surgery, University of Giessen, Giessen, Germany. Intravenous immunoglobulin (IVIG) administration provides an established treatment modality to reverse steroid resistant rejection and to suppress alloantibody formation in sensitized recipients. To analyze graft protective effects of IVIG induction therapy, we performed a prospective randomized study in 50 renal transplant recipients who were randomly assigned to receive 7x10g IVIG and 7x10g iv albumin infusions, respectively. Immunological tests were performed up to 3 years, and clinical followup data were analyzed up to 5 years posttransplant. IVIG induction therapy did not affect sCD30 and sIL1-RA levels. However, regulatory autoantibody levels were increased in IVIG patients on day 10 (IgG anti-Fab and anti-F(ab)2: p≤0.005; IgA anti-Fab, anti-F(ab)2 and anti-hinge: p<0.05). IVIG patients showed an enhanced monocyte IL-10 production early posttransplant (day 30: p=0.011, unstimulated; p=0.049, LPS), followed by downregulated monocyte activation (p=0.024, 4-month neopterin) and profoundly suppressed 1-year CD4 helper activity compared to non-IVIG patients (p=0.003; logistic regression: p=0.001). However, between IVIG and non-IVIG patients no signifi cant differences were found in 5-year patient and graft survival, graft function, incidence of acute rejections and chronic graft dysfunction. In non-IVIG patients, serum IgG and IgA levels were signifi cantly decreased only within the fi rst 20 days posttransplant compared to IVIG patients (p=0.001, IgG; p=0.039, IgA). The incidence of severe infectious disease, CMV viremia and CMV disease was not signifi cantly different at any time point. Our data show that IVIG induction is associated with potentially graft protective immunological effects: increased regulatory autoantibody levels and upregulated monocyte IL-10 production early posttransplant, followed by downregulation of monocyte activation at 4 months and a profound decrease in CD4 helper activity at 1 year posttransplant. However, no improved clinical outcome (graft outcome; risk of infection) was found up to 5 years posttransplant in this cohort of immunologically low-risk patients. DISCLOSURES: Weimer, R.: Grant/Research Support, Astellas, Novartis. Abstract# C1799 Comparison of Effi cacy and Safety of Different Induction Therapies in Kidney Transplantation From Donation After Cardiac Death. G. Chen, X. Lai, J. Qiu, C. Wang, M. Han, X. He, L. Chen. Organ Transplant Center, The First Affi liated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China. Background Thymoglobulin and ATG-Fresenius (ATG-F) are both commonly used as induction therapy in kidney transplantation from donation after cardiac death (DCD). We carried out a retrospective study to compare the effi cacy and safety between these two induction therapies in DCD kidney transplantation. Method We retrospectively analyzed 255 cases of DCD kidney transplantation performed in our hospital from February 2007 to October 2013. The patients were divided into two groups based on their induction therapies with thymoglobulin (n=188) or ATG-Fresenius (n=67). All patients were followed up for at least 3 months. The primary endpoints included delayed graft function (DGF), acute rejection, graft loss and patient death. Postoperative complications were also compared between two groups, including infection, leucopenia, thrombocytopenia, and tumors. Results DGF occurred in 36(19.1%) patients in thymoglobulin group versus 17(25.4%) patients in ATG-F group (p=0.281). However, if we selected the patients with increased risk factors for DGF (includi


A Malaysian woman won her case againts the US government's "no-fly"policy that restrains individuals from commercial air travel due to suspected ties to terrorism.


After "Sixth-Five", natural gas geology has made great progress on many aspects, such as natural gas formation, natural gas reserves, how to recognize and evaluate natural gas and natural gas pools, the formation conditions and distribution laws on large-medium gas fields. And the natural gas geology has been formed in China. The natural gas re serves increase rapidly based on these achievements from then on. It is very important to think deeply on the problems whether the natural gas resources are well provided and have great potentialities, and on the development prospect and quantitative ( even time) evaluation of natural gas resources in order to determine the development strategy of natural gas industry in China. It is very clear that the natural gas resources are not rich in China based on the research results, exploration practice and the contrast between the domestic and international resources of natural gas and other fossil fuels (coal, petroleum and so on). But the natural gas exploration is still at a low level and has great potentialities. The duty of natural gas geologic researchers is not to explain whether natural gas and petroleum exist, but to look for the factors how to discover great natural gas pools. It it very important to strengthen the basis research or natural gas in order to solve the problems how to develop natural gas industry. We should lake notice o: three problems for the basis research al present, tha is. resources, the pool-formed mechanism and com
prehension. Natural gas resource is the important aspect on the basis research. We should think highly of conventional and non-conventional natural gas resources. The problem of pool-formed mechanism is the forceful point from beginning to end. At the same time, we should pay attention to the comprehensive research including basis geologic study, new-method and new-technology application.


Abstract In order to compare the polarographic behaviour of cis and trans aliphatic azoxy compounds, synthesis and polarographic study of cis and trans azoxycyclohexanes are performed. The cis form is a new compound obtained by photoisomerisation of the trans compound. In acid medium the polarographic reduction process is the same for both forms: hydrazocyclohexane is the final reduction product. In alkaline medium the trans azoxy compound is electroinactive and the cis azoxy compound is reducible and leads to a mixture of trans azocyclohexane and hydrazocyclohexane.


The difficulty that restricts the funds circulating is an outstanding problem that restricts the development of private operated busine ss of our country; and the cause of this problem is from various aspects; the ba sic way out to break this restriction lies in the innovation of institutions and the policy aid from the government.


In this paper,a new max min fairness criterion is defined on the basic of utility function to realize fair allocation in utility.For ABR service the other two equivalent definitions of utility max min(UMM)fairness are proposed taking into account the minimal and maximal demands of users,and a centralized algorithm is devised to calculate the UMM fair share.Furthermore,we give the peak cell rate a new meaning in that it prevents from inefficient allocation caused by the saturation of user demand.UMM fairness not only generalizes the previous max min fairness in ABR service but also can be applied to a wide range of network resource allocation problems,especially with various kinds of applications.


A 260GHz on-off keying (OOK) transmitter (Tx) is presented with distributed switches in V-band fundamental signal path in 65 nm CMOS. Aiming at OOK modulation operating upto 20Gb/s, distributed switches are integrated in the driving chain to suppress transient ringing from a LC tank in the PA where the modulated input directly switches the Tx output without information distortion. The spatially combined transmitter with on-chip antenna demonstrates upto 14Gb/s of modulation speed with +5 dBm of equivalent isotropically radiated power (EIRP) at fr = 246GHz.


Transposable elements (TEs) compose about half of the mammalian genome and, as embedded sequences, up to 40% of long noncoding RNA (lncRNA) transcripts. Embedded TEs may represent functional domains within lncRNAs, providing a structured RNA platform for protein interaction. Here we show the interactome profile of the mouse inverted short interspersed nuclear element (SINE) of subfamily B2 (invSINEB2) alone and embedded in antisense (AS) ubiquitin C‐terminal hydrolase L1 (Uchl1), an lncRNA that is AS to Uchl1 gene. AS Uchl1 is the representative member of a functional class of AS lncRNAs, named SINEUPs, in which the invSINEB2 acts as effector domain (ED)‐enhancing translation of sense protein‐coding mRNAs. By using RNA‐interacting domainome technology, we identify the IL enhancer‐binding factor 3 (ILF3) as a protein partner of AS Uchl1 RNA. We determine that this interaction is mediated by the RNA‐binding motif 2 of ILF3 and the invSINEB2. Furthermore, we show that ILF3 is able to bind a free right Arthrobacter luteus (Alu) monomer sequence, the embedded TE acting as ED in human SINEUPs. Bioinformatic analysis of Encyclopedia of DNA Elements‐enhanced cross‐linking immunoprecipitation data reveals that ILF3 binds transcribed human SINE sequences at transcriptome‐wide levels. We then demonstrate that the embedded TEs modulate AS Uchl1 RNA nuclear localization to an extent moderately influenced by ILF3. This work unveils the existence of a specific interaction between embedded TEs and an RNA‐binding protein, strengthening the model of TEs as functional modules in lncRNAs.—Fasolo, F., Patrucco, L., Volpe, M., Bon, C., Peano, C., Mignone, F., Carninci, P., Persichetti, F., Santoro, C., Zucchelli, S., Sblattero, D., Sanges, R., Cotella, D., Gustincich, S. The RNA‐binding protein ILF3 binds to transposable element sequences in SINEUP lncRNAs. FASEB J. 33, 13572‐13589 (2019). www.fasebj.org


Abstract : The report compares a number of remote sensors to determine the feasibility of using these sensors for detecting oceanographic features from space. The sensors include an infrared scanner, infrared radiation thermometer, radar scatterometer, radar wave profiler, and a microwave radiometer. Two aircraft flew a series of flight tracks across the Gulf Stream near Cape Hatteras and over ARGUS ISLAND Tower located southwest of Bermuda. The sensors were compared and evaluated by means of simultaneous measurements. In addition, a quantity of Rhodamine-B dye released in the water was photographed to determine if certain characteristics of water flow could be estimated from aerial photographs.


Objective  Health‐related quality of life (HRQOL) scores produced by simply summing individual item values have been criticized for lacking linearity and for not being equally discriminating across the range of scores. Differences in summed scores may depend more on their starting point on the scale rather than actual differences in the underlying dimension of HRQOL, making it difficult to judge what a particular score means. We sought to examine the usefulness of an alternative method of scoring questionnaires, item–response theory (IRT), for the clinical interpretation of a modified version of the Marks Asthma Quality of Life Questionnaire (MAQLQ‐M).


The utility model provides a shaft coupling adjusting operation learning testing stand, relates to an experimental operation device and especially belongs to an experimental device for learning adjustment of concentricity of a shaft coupling by utilization of a dial gauge. The testing stand is equipped with a pedestal (7). The testing stand is characterized in that, a support (3) is arranged above the pedestal, a fixation disc (1) and a rotation disc (2) are relatively fixed on the support respectively, and the rotation disc carries out position adjustment through a base plate (6), a horizontal adjusting jackscrew (4) and a vertical adjusting jackscrew (5) which are located on the upper surface of the pedestal. The testing stand has active effects of learning convenience and easy operation.


By Cole Nevins, M.S. Washington State University May 2009 Chair: Christopher Hundhausen Many novice programming environments utilize a dua l-representation interface to display code textually and graphically. None has explored t he design implications of Dual-Coding and Cognitive Load Theories, which offer significant in sight into the benefits and pitfalls of presenting novice programmers with two separate vie ws of program code. To address this gap, I have surveyed the existing Dual-Coding and Cognitiv e Load literature and identified a promising design modification to dual-representation novice p rogramming interfaces: correspondence highlighting. I implemented correspondence highlighting in the ALVIS L IVE! novice programming environment. When an element in the cod e window of the ALVIS LIVE! environment is selected, ALVIS LIVE! highlights tha element and its corresponding element in the animation window is highlighted in a color uni que to that element. When an element in the animation window is selected, that element and ever y reference to that element in the code window highlighted. In an experimental study, this ighlighting mechanism failed to provide a significant performance advantage over a version of ALVIS L IVE! without correspondence highlighting. I examine why this might be the case, and propose directions for further research into the effect of cognitive load on novice program mer performance, as well as opportunities for improving novice programming environments at every stage of learner experience.


This paper presents some measurements of wind speed and direction obtained by a LDA system. The case was a squall-line event on June 2, 1992 at Lichtenau, a location 50 km approximately southwest of Munich. The measurements were taken during the pass of a squall-line and after.


Tumours evolve to cope with environmental stresses or challenges such as nutrient starvation, depletion of survival factors, and unbalanced mechanical forces. The uncontrolled growth and aberrant deregulation of core cell homeostatic pathways induced by genetic mutations create an environment of stress. Here, we explore how the adaptations of tumours to the changing environment can drive changes in the motility machinery of cells, affecting migration, invasion, and metastasis. Tumour cells can invade individually or collectively, or they can be extruded out of the surrounding epithelium. These mechanisms are thought to be modifications of normal processes occurring during development or tissue repair. Therefore, tumours may activate these pathways in response to environmental stresses, enabling them to survive in hostile environments and spread to distant sites. © 2020 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.


This article begins by focusing that there are no researches about the sense of unease nor well-being of teachers. It considers that it exists a specific teachers' sense of unease in the present as a result of the last social and educative changes and indicates how the well-being is determinate by our own believes and our ability to get our life's success. Later, this article shows us the emotional thinking method, a method based on the emotional intelligence model conceived by Salovey and Mayer in 1990 and disseminated by Daniel Goleman since 1995. The aim of this method is to change negatives and positives emotions and feelings. This one has been created by this article's author as a method for improving individual competences and for teaching university and non university teachers in emotional competences or skills. Every of the seven emotional competences which are described by this method is developed in this entry; the first four competences which are referred to oneself are: self-knowledge, selfsteam, emotional control and motivation; the last three are referred to the others: others' knowledge, others' steam an d leadership. The method indicates also some


The invention relates to the field of mining devices, in particular to a single-cylinder type cone crusher. The single-cylinder type cone crusher comprises a machine frame, a transmission mechanism, an eccentric mechanism, a hydraulic lifting mechanism, a movable cone main shaft set and a supporting assembly, wherein the transmission mechanism, the eccentric mechanism, the hydraulic lifting mechanism, the movable cone main shaft set and the supporting assembly are arranged in the machine frame. The eccentric mechanism is in transmission connection with the transmission mechanism. The lower end of the movable cone main shaft set is located and installed in the eccentric mechanism. The hydraulic lifting mechanism is located below the movable cone main shaft set. The hydraulic lifting mechanism and the movable cone main shaft set are connected through the supporting assembly. The single-cylinder type cone crusher is high in stability and strength.


In a real time system contained various type of scheduling algorithms. They are used for determine which processes should be executed by the CPU when there are different processes to be executed. Neuro fuzzy logic approaches are very effective for scheduling real time task. This paper presents a review on scheduling algorithm of real time task. Then, discuss the limitations of EDF algorithm and features of neuro fuzzy system. We proposed neuro fuzzy scheduler using EDF to overcome the drawbacks of other algorithms for better scheduler performance of real time task.


eritoneal dialysis (PD) is an established and beneficial eplacement treatment for patients affected by end-stage enal disease (ESRD).1 Long-term peritoneal dialysis (PD) s associated with the progressive development of funcional and structural alterations of the peritoneal membrane ffecting the outcome, such as angiogenesis, the formaion of new blood vessels from pre-existing endothelium.1 ascular endothelial growth factor (VEGF), an angiogenic nd vascular permeability factor, is a major mediator of ncreased angiogenesis.2 The aim of this study was to examine the factors nfluencing the serum (s) and drained dialysate (dd) VEGF oncentrations in chronic PD patients and their correlaions with biochemical findings, quality of PD, peritoneal embrane transport rate, dialysis modality and vintage, eritonitis and diabetes mellitus, use of erythropoietin stimuating agents (ESA), angiotensin-converting enzyme inhibitors ACEi) and statins. The observational study included 63 prevaent patients (39 males, 24 females), middle age 61.97 ± 11.01 ears, treated with PD during 24 ± 18 months, using conentional low pH (5.5) peritoneal dialysate solutions with lucose concentration 1.25–2.76% at the Clinic of Nephrology, linical Centre of Serbia in Belgrade, Serbia. Fifty-three (84.5%) atients were on continuous ambulatory peritoneal dialysis CAPD), 6 (9.5%) on automated peritoneal dialysis (APD) and (4.5%) on cycling peritoneal dialysis, i.e. manual day dwells ith dry period during the night (CCPD). Patients were free f peritonitis and clinical or laboratory signs of any infection t least 4 weeks before they were enrolled; 31 (49.2%) patients ere affected by diabetes mellitus; 38 (60.3%) patients had one r more episodes of peritonitis; 41 (65%) patients received ESA,


The Swedish Ministry for Foreign Affairs has taken a hugely important initiative to invite a global dialogue "exploring connections between sexuality sexual rights and economic development and the realisation of a broad spectrum of human rights - not just health but also economic development peoples livelihood options as well as their physical and psychological well-being" (cited from Terms of Reference for this paper). This paper constitutes a contribution to that dialogue. It discusses the current global context around sexuality conceptions of sexuality underlying development action development engagement with sexuality to date and some thoughts on how development actors can support a move towards more positive sexual rights and freedoms while avoiding imposing dominant or culturally specific preconceptions on what sexuality is and how sexual practices should be. (excerpt)


The primary reactions of solar energy conversion in photosynthetic bacteria are accomplished via photoinduced electron transfer through a series of pigments in reaction center (RC) proteins. An electron is transferred from the photoexcited state of the special pair P* to a bacteriopheophytin H A, then to ubiquinones Q A and QB (Figure 1) [1]. In this study, the RC protein structure in the QA/QB region was examined by x-ray absorption fine structure (XAFS) using an intrinsic non-heme Fe 2+ site as a probe. XAFS spectra at Fe K-edge for the Fe 2+ site in RC proteins at different purification stages were measured. Two XAFS studies on the Fe site of the bacterial photosynthetic RC proteins were conducted in the early 1980s [2, 3]. Since then, several crystal structures of RCs have been published. However, the structural accuracy around the Fe site obtained from the x-ray crystal structures of RC is limited due to the


The coat protein(CP) gene of Tobacco Vein Banding Mosaic Virus(TVBMV) from Shaanxi province was obtained by RT-PCR.Sequence analysis showed that TVBMV CP gene was 813 nt long and encoded a 271 amino acid protein.Homology analyzed between TVBMV CP and other 9 strains in GenBank were 90.28%-98.15% at nucleotide level,and 97.05%-100% at amino acid level.The CP gene was cloned into pMD18-T Simple Vector and inserted into pET30a which were cleaved with restrict endonuclease BamH I/Not I.The expression vector of pET30-TVBMV CP was constructed and transformed into BL21 host strain of E.coli and induced expression by IPTG.The special antisera were prepared by immunizing rabbit with expressed product as antigen.Results showed that TVBMV CP was highly expressed in BL21 and molecular weight of expression product was about 37 kD.The antisera gave a titer of 1/2048.Western blot revealed that the prepared antisera can be used to detect tobacco infected by TVBMV.


SF6 is colorless and non-toxic, with good insulation properties, and is therefore widely used in the electrical industry. However, in the possess of the transportation, installation and use of electrical equipment, some conductive impurities, electrode defects and etc. inevitably appear, resulting in uneven electric field and partial discharge. Under the action of electric field and high energy current, SF6 decomposes and reacts with $\mathrm{H}_{2}\mathrm{O},\mathrm{O}_{2}$ and organic substances to produce a variety of characteristic gases. This study is based on the density functional theory (DFT), CS2 is used as the detection gas, and the two-dimensional material $\mathrm{Ti}_{3}\mathrm{C}_{2}\mathrm{~T}_{x}(\mathrm{~T}=\mathrm{O},\mathrm{F},\mathrm{OH})$ is selected as the sensing material, and the adsorption model of $\mathrm{Ti}_{3}\mathrm{C}_{2}\mathrm{~T}_{\times}$and CS2 is established, and the adsorption energy, distance between gas and substrate, structural changes of the adsorption system, electron transfer and density of states(DOS) of the system were further analyzed. The results indicate that the adsorptions of CS2 on the surface of $\mathrm{Ti}_{3}\mathrm{C}_{2}\mathrm{~F}_{2}$ and Ti3C2O2 were weak and both were physical adsorptions, while the adsorption on the surface of Ti3C2OH2 was chemical adsorption with a greater adsorption energy and significant charge transfer, and the Figure of the DOS changes showed that CS2 improved the DOS near 0eV (Fermi level) and the electrical conductivity of the material was improved. These results suggest that $\mathrm{Ti}_{3}\mathrm{C}_{2}\mathrm{~T}_{x}$ has the potential as a sensing material.


Objective To investigate the relationship between nonalcoholic fatty liver disease(NAFLD)and the severity of coronary artery disease (CAD). Methods Retrospective cross-sectional studies were conducted to examine the relationship between NAFLD and the severity of CAD. CAD was diagnosed by coronary angiography and NAFLD by type-B ultrasound. Results The logistic regression analysis showed that hypertension, NAFLD, diabetes, smoking, and high level of γ-glutamyltransferase were risk factors of multiplevessel lesions and occlusion of CAD( P<0.05 or P<0.01 ) , and high levels of total cholesterol and alanine aminotransferase were risk factors of multiple-vessel lesions ( P<0. 05 or P<0.01 ) , family history was a risk factor of occlusion of CAD, whereas, high level of high-density lipoprotein cholesterol was an important protective factor of multiple-vessel lesions and occlusion of CAD ( P<0. 01 ). NAFLD was a dependent risk factor of multiple-vessel lesions and occlusion of CAD( P<0.05 or P<0. 01 ). Conclusions NAFLD could be regarded as a main risk factor of the severity of CAD. Clinicians should pay more attention to the prevention and treatment of NAFLD in order to improve the outcome of CAD.

Key words:
Nonalcoholic fatty liver disease;  Coronary artery disease;  Multiple-vessel lesions;  Occlusion;  Risk factors