The Huangmao Island dumping area is adjacent to the Pearl River Estuary in the South China Sea. From its first dumping activity in 1986 to 2017, 6750 × 104 m3 dredged materials were dumped in this dumping area. Sediment pollution levels, ecological risk, and benthic communities in 2011–2017 were evaluated; the results showed that the concentrations of the heavy metals (HMs; except Hg) in surface sediments of the dumping area met the class I standard of marine sediment quality (GB 18668-2002). HMs in the surface sediments were relatively high in the northern and central areas but relatively low in the south of the dumping area. Speculation was that the spatial variation in HM concentrations might be caused by dumping activities. The Nemerow index implied that the contaminated area was mainly in the north of the dumping area (S1, S2, and S3), where the dumping amount was the largest. The potential ecological risk (Eir) indices of Zn, As, Cu, and Pb indicate that these metals posed a low risk to the ecosystem of the dumping area, whereas Cd and Hg posed a high risk at some stations. The geoaccumulation indices (Igeo) of Zn, As, Cu, and Pb specified no pollution or light pollution in the study area, whereas those of Cd and Hg in most years indicated mild contamination levels. Benthic organisms in the study area were arthropods, chordates, annelids, mollusks, echinoderms, nemertinean, coelenterate, and echiuran, among which arthropods were the most abundant. The abundance of taxa and density of benthic organisms had a little difference among the stations within the dumping area, but were significantly lower than those of the stations outside the dumping area. In addition, non-metric multidimensional scaling analysis confirmed that the observed patterns separated the stations within the dumping area from stations outside the dumping area. The evaluation results of the HMs revealed that the dumping area with a large dumping amount was more severely polluted. Dumping dredged materials seemed to have a negative impact on the benthic community in the dumping area.


Four pairs of primers were designed to amplify E1 and E3 of CAV-2C.We cloned these fragments into pMD18-T Vector,which was subsequently sequenced.We constructed transfer vector deleted E3 with EGFP marker gene.Then vector expression was carried out in MDCK and 293-T.The results showed that the transfection efficiency in MDCK was very low,while higher in 293-T cell.We laid foundation in this study for adenovirus vector construction.


A dissertation submitted in partial fulfillment of the requirements of the degree of Master of Social Work, Faculty of Social Sciences

Citation: Kunda, Hope M. (2007) Psychosocial causes of suicide among youth and its implications on the family: lessons for Botswana, University of Botswana


For decades, medical researchers in the UK have highlighted difficulties accessing patient data for research. They have described multiple challenges: the parallel regulatory frameworks protecting personal data through data protection law (the 'UK GDPR') and common law protecting the disclosure of confidential information; the ethical principles enshrined in professional medical practice reinforcing the importance of medical confidentiality; and an undercurrent of public concern about potential for confidential patient information (CPI) to be exploited or abused. In March 2020, this complex landscape was disrupted through the publication of control of patient information or 'COPI' notices by the Secretary of State for Health and Social Care to mandate the sharing of CPI for COVID-19 purposes. After two years and four extensions, most of these notices have now been withdrawn. This experience provides a useful natural experiment for those who have been calling for streamlined governance of patient data for research purposes and suggests a number of lessons for future regulatory directions.


We present a multi-UAV system capable of localizing radio tagged animals. Each UAV carries a Yagi antenna and is capable of obtaining bearing-measurements by using the directionality of the signal emitted from the tag. In this paper, we address the following question: given a set of measurement locations, should the UAVs move in coordination and obtain synchronized measurements, or should they move independently? For each scenario, we present a path planning algorithm. The algorithms are compared in simulations. We also present a complete system implementation with three UAVs and results from field experiments.


This book contains the proceedings of numerical methods in multiphase flows. Topics covered include: Turbulent Flow; Fluidized-bed Hydrodynamic; Nozzles; Two-Phase Flow.


This paper gaves a simple introduction of evidence theory and analysed the cause of absurdities.A new method of dispelling the absurdities was presented.This method could dispel the absurdities generated by D-S combination formula by making all experts make their decision on the same focuses collection.The rightness and the efficiency of this method were proved by several examples.Simulation algorithm to dispel the absurdities was given in the end.


Background

We aim to assess the associations between night sleep duration and fasting glucose (FG), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio, and body mass index (BMI) among adults free of type 2 diabetes (T2D) or without diagnosed T2D.
Methods

We analyzed the baseline data of a cohort. We included adults free of T2D or without diagnosed T2D who completed the validated questionnaire, biochemical and anthropometric measurements. Independent association between sleep duration and FG, TG/HDL-C, BMI was evaluated with multiple U-shaped or linear regressions.
Results

We included 32497 adults with a median of 44 years, 52.5% men. Overall, 12.80% and 9.67% reported night sleep duration <7h and ≥9h, 6.91% were with impaired FG and 3.57% had undiagnosed T2D. Sleep duration was independently U-shaped associated with FG [β1 (linear term) =-0.111, P=0.047; β2 (quadratic term) =0.008, P=0.026] with 6.9-hour sleep had the lowest FG, and negatively associated with BMI (β = -0.154, P<0.001). BMI mediated U-shaped association of sleep duration with TG/HDL-C (β1=-0.040, P=0.017; β2 = 0.003, P=0.023).
Conclusions

Both short and long night sleep was associated with elevated FG, shorter sleep was associated with increased BMI. BMI mediated the U-shaped association between sleep duration and TG/HDL-C.


In order to study effectiveness of measures taken to protect mountain bridge piers against rockfall in the upper reaches of the Minjiang River in Sichuan, based on non-linear explicit dynamic analysis, a numerical model was established to analyze the effectiveness using Holmquist–Johnson –Cook(HJC) damage constitutive model .And the numerical stability of calculation was tested in accordance with energy conservation principle. Four working conditions of bridge pier, namely ordinary non-protection, encryption stirrups, thickening plain concrete protection layer, being wrapped in steel tube, had been analyzed.Then by studying the response characteristics of the pier including the maximum damage depth of concrete, stress of longitudinal rebar, failure volume of concrete, different effectiveness of the three protective measures was compared . The rationality of analysis was verified by comparing with experimental results.The study shows that the HJC constitutive model can simulate the behavior of concrete under impact load well, and respectively protective effect of being wrapped in steel tube , thickening plain concrete protection layer, encryption stirrups, is weaker than the previous one.


We provide an experimental evaluation of a wearable augmented reality (AR) system we have developed for human-robot teams working on tasks requiring collaboration in shared physical workspace. Recent advances in AR technology have facilitated the development of more intuitive user interfaces for many human-robot interaction applications. While it has been anticipated that AR can provide a more intuitive interface to robot assistants helping human workers in various manufacturing scenarios, existing studies in robotics have been largely limited to teleoperation and programming. Industry 5.0 envisions cooperation between human and robot working in teams. Indeed, there exist many industrial tasks that can benefit from human-robot collaboration. A prime example is high-value composite manufacturing. Working with our industry partner towards this example application, we evaluated our AR interface design for shared physical workspace collaboration in human-robot teams. We conducted a multi-dimensional analysis of our interface using established metrics. Results from our user study (n = 26) show that, subjectively, the AR interface feels more novel and a standard joystick interface feels more dependable to users. However, the AR interface was found to reduce physical demand and task completion time, while increasing robot utilization. Furthermore, user's freedom of choice to collaborate with the robot may also affect the perceived usability of the system.


The purpose of this research is to take advantage of Artificial Intelligence which is used to increase Creativity Skills in the era of society 5.0. Data collection is done to see subtle problems and develop solutions. Technique data collection is a literature study. Creativity Skill is one of the abilities that students must have to answer challenges, namely the era of society 5.0. The era of society 5.0 is an era where new values created by technological developments can minimize human responsibility and future economic problems. In this case, Artificial Intelligence is a way to maximize students in social change which requires someone to be innovative, creative by emphasizing contextual learning in which students must be active. Artificial intelligence (AI) enables machines to learn from experience, adapt to new inputs and perform human-like tasks. Most of the AI you hear about today - from computers playing chess to adult cars - rely heavily on deep learning and comparing natural language. Using this technology, computers can complete specific tasks by processing large amounts of data and managing patterns in the data so that it is hoped that the use and development of Artificial Intelligence can increase creativity skills to face opportunities and challenges in the era of 5.0 society.


Energy production from biomass is gaining a lot of attention. Algal oil (microand macroalgae) can be used for biofuel production. Biofuels from this type of feedstock are called third generation biofuels or advanced biofuels. Focus of this paper is on the microalgal biofuels and on the available process technologies. Very important advantage of microalgal biofuels is that microalgae can be cultivated on any type of land, with the possibility of using wastewater streams. Microalgae can be cultivated in open systems, so called "raceway ponds" or in closed systems - photobioreactors: flat panel photobioreactors, horizontal tubular, vertical tubular photobioreactors with or without airlift. Also, basic information on cultivation conditions (photoautotrophic, heterotrophic, mixotrophic and photoheterotrophic) are presented. Available technologies for microalgal biofuels production are: transesterification, fermentation, pyrolysis, hydrothermal liquefaction, anaerobic digestion and biomass to liquids (BtL). Additionally, basic information on life cycle assessment of microalgae cultivation and CO2 sequestration potential is given in the final chapter of this work.


Silicon carbide foam ceramics were prepared at 800 °C with polyurethane sponge as a template, aluminum dihydrogen phosphate as a binder, silicon carbide powder as an aggregate. The effects of aluminum dihydrogen phosphate content, solid content and high-temperature treatment on the linear shrinkage, volume density, flexural strength, porosity and microstructure of the silicon carbide foam ceramics were investigated. The properties and structure evolution of the SiC foam ceramics treated at a high temperature were revealed. The results show that the linear shrinkage of the SiC foam ceramics is less than 1%, which gradually decreases with increasing the solid content. The volume density and flexural strength of the SiC foam ceramics increase with the increase of the aluminum dihydrogen phosphate and solid content. After the high-temperature treatment, the linear shrinkage, volume density and flexural strength of the SiC foam ceramics firstly decrease and then increase with increasing the temperature, and the open porosity firstly increases and then decreases. At the treatment temperature of 1 000 °C, the flexural strength is (2.06±0.1) MPa. The SiC foam ceramics are bindered by A-Al(PO3)3 and B-Al(PO3)3 at a low temperature. B-Al(PO3)3 gradually transforms to A-Al(PO3)3 when the treatment temperature increases, and A-Al(PO3)3 gradually breaks down into AlPO4 when the temperature further increases, resulting in the silicon carbide particles to be coated and bonded together.


The utility model discloses a nested threaded fastener, comprising an outer bolt, an inner bolt and a spacing seat arranged between the inner bolt and the outer bolt, wherein an internal thread blind hole is arranged on the outer bolt, and the opening of the internal thread blind hole is located at the top of the bolt cap of the outer bolt; a screw rod of the inner bolt is matched with the internal thread blind hole; and a through hole through which the screw rod of the inner bolt can pass but the bolt cap cannot pass is arranged at the middle part of the spacing seat. The nested threaded fastener can fix a plurality of components under the condition that no extra space is occupied.


We used whole genome resequencing of pooled individuals to develop a high-density single-nucleotide polymorphism (SNP) chip for Eucalyptus. Genomes of 240 trees of 12 species were sequenced at 3.5× each, and 46 997 586 raw SNP variants were subject to multivariable filtering metrics toward a multispecies, genome-wide distributed chip content. Of the 60 904 SNPs on the chip, 59 222 were genotyped and 51 204 were polymorphic across 14 Eucalyptus species, providing a 96% genome-wide coverage with 1 SNP/12-20 kb, and 47 069 SNPs at ≤ 10 kb from 30 444 of the 33 917 genes in the Eucalyptus genome. Given the EUChip60K multi-species genotyping flexibility, we show that both the sample size and taxonomic composition of cluster files impact heterozygous call specificity and sensitivity by benchmarking against 'gold standard' genotypes derived from deeply sequenced individual tree genomes. Thousands of SNPs were shared across species, likely representing ancient variants arisen before the split of these taxa, hinting to a recent eucalypt radiation. We show that the variable SNP filtering constraints allowed coverage of the entire site frequency spectrum, mitigating SNP ascertainment bias. The EUChip60K represents an outstanding tool with which to address population genomics questions in Eucalyptus and to empower genomic selection, GWAS and the broader study of complex trait variation in eucalypts.


Abstract
In the post-industrial information society, the role of mass communication, public information, information space, social and political discourse, as well as the Internet as a new communication environment becomes exceptional. According to the widespread view, the social system and history as a whole change not only the development of material production, but also the improvement of information resources. Information technologies are now widely used both in the activities of commercial organizations and public authorities. In this chapter, the authors discuss the key aspects of economic interaction of the world information economy and the features of the development of Russian society in this process.


The interaction effects between confluence rainfall of city and hydraulic structure are discussed in this paper.The design method of confluence rainfall and hydraulic structure associated works is provided and the basic equation of unsteady flow of coupling slope and drainage project is established.


For the past one hundred years or so, Chinese philosophy has not formed its own paradigm. Practice shows that there is a deep interactive relationship between text and paradigm. From the history of the Western and Chinese philosophy, the paradigm should come from the text. However, this does not mean the paradigm does not have its relative independence nor negates its importance. Just as classical texts have eternal value, so paradigms that stand the test of time have eternal value too.


The implantation procedure of left ventricular (LV) leads and the management of cardiac resynchronization therapy (CRT) patients can be challenging. The IS‐4 standard for CRT offers additional pacing vectors compared to bipolar leads (IS‐1). IS‐4 leads improve procedural outcome and may also result in lower adverse events during follow‐up (FU) and improve clinical outcome in CRT patients. Further long‐term FU data comparing the two lead designs are necessary.


We have studied the variation of perpendicular magnetic anisotropy (PMA) of CoFeB layers with the oxidation degree of the MgO buffer layers. After annealing at 330 °C, the out-of-plane anisotropy field (Hk) of 1.5-nm CoFeB could be optimized to 3.1 kOe. To investigate the orbital hybridization of the Fe-3d and O-2p, the orbital moments per hole (morb/Nh) of Fe in annealed CoFeB layers were extracted by using x-ray magnetic circular dichroism. The dependence of morb/Nh on the oxidation time of MgO coincided with that of Hk, which revealed that PMA of annealed CoFeB originated from the interfacial orbital hybridization.


OBJECTIVE To establish the genotype profiles of Citrobacter freundii by randomly amplified polymorphic DNA(RAPD) technique.METHODS The optimal reaction system and single random primer L8 were used for genotyping of the 116 strains of C.freundii isolated from clinical samples,and the fingerprinting profiles were drawn according to the numbers and lengths of DNA bands.RESULTS The 116 strains of C.freundii isolated from clinical samples could be distinguished to 78 kinds of RAPD patterns.CONCLUSIONS Seventy eight kinds of genotype profiles could be obtained by RAPD technique in the C.freundii isolated from clinical samples.


The paper explores the linguistic landscape in schools (schoolscape) and their messages transmitted as hidden curricula and covert semantic representations. The concept of schoolscape refers to the totality of visual materials, such as notice boards, tableaus, displays, teaching materials, maps, building signs, marks, etc. that can be found within the space of a school. These reflect on the life and communicational needs of the social environment, articulated in a given period of time. This visual linguistic configuration of the educational scene is an essential part of the "hidden curriculum" of the pedagogical space at hand. The study relies on empirical data obtained in a specific field, namely, in the schools of a Hungarian ethnic minority community from Romania where bilingualism represents a special form of social existence. Data were collected through the observation and documentation of the linguistic landscape, through focus group discussions with pupils and individual interviews with the educators. The paper offers a detailed description of the schoolscapes' general characteristics, and a thematic analysis of these landscapes; it also presents the representations of local identity and patterns of language use as they are displayed and constructed by the visual configuration of the given spaces.


In this study, we investigated the modelling and optimization of drinking water supply system reliability in the village of Zaben, Czech Republic. An in depth overview of the water supply network in the municipality, passport processing and accident and malfunction recording is provided based on data provided by the owner and operator of the water mains as well as the data collected by our own field survey. Using the data processed from accident and failure reports in addition to water main documentation, the water supply network in Zaben was evaluated according to the failure modes and effects analysis methods. Subsequently, individual water supply lines were classified based on their structural condition. In addition, a proposed plan for financing the reconstruction of the water supply mains in Zaben was created. As such, this study provides an overall assessment of the water supply network in Zaben alongside a proposed plan for the structural restoration of the water supply system, which accounts for the theoretical service life of the system and the financial resources of the owner.


Measurements of the 16O and 18O distribution functions in the solar wind at low to average solar wind speeds from the MASS instrument on the Wind spacecraft are reported. The 16O/18O density ratio is 450 ± 130, a value consistent with terrestrial, solar photospheric, solar energetic particle, and galactic cosmic ray 16O/18O isotopic ratios. This study constitutes the first reported spacecraft measurement of the isotope 18O in the core solar wind and may represent the best determination of the solar 16O/18O density ratio to date.


The aim of this article is to examine trends in student access and performance at university during the implementation of the "Bologna Process". We focus on the universities in Milan in order to assess whether and to what extent institutions with different characteristics experienced differentiated changes in both first-year students composition and performance. The analysis of administrative data suggests that the reform favored a growth of enrolments and an heterogeneous change in student characteristics. Public and large universities attracted mainly students with a weaker school background, while in the private and more prestigious universities the proportion of new entrants from the secondary academic track did not decrease at all. Furthermore, there has been an overall improvement in student performance (early drop-out and exams inactivity) and a reduction of its heterogeneity across universities. Further research should address whether this is due to organizational improvements or simply reflects a lowering of academic standards.


Tuberous sclerosis is an autosomal dominant genetic disease that involves multiple organs. Hamartomas are the predominant lesions. Classically, tuberous sclerosis has been characterized by a classical clinical triad of facial angiofibromas (90%), mental retardation (50-80%), seizure (80-90%) and all three in 30% of the patients. Two major features or one major feature plus two minor features are necessary for the definite diagnosis of this disease. We had some patients admitted with different presentations of tuberous sclerosis and a past history of convulsion from childhood, skin lesions and also mental retardation with a new onset headache and a changed pattern of convulsion. In physical examination, facial angiofibromas and subungual fibromas were apparently detected. Brain CT scan study with contrast showed multiple calcified nodules associated with tubers, ventriculomegaly and also enhancing enlarged nodules at the foramen of Monro, which were suggestive of subependymal giant cell astrocytoma (SGCA). MRI showed the same brain findings (tubers, white matter lesions and subependymal nodules associated with SGCA), which were detected better. After surgery, SGCA was proved. In abdominal and pelvic CT scan and ultrasonography, massive bilateral angiomyolipomatosis and focal hypodense hyperechoic liver lesions were detected.


The purpose of this study is to confirm that work to family conflict (W to FC), family to work conflict (F to WC) and work family balance (WFB) are the predictors of job satisfaction (JS) for Malaysian academic community. To achieve the fundamental objective, the authors first test the direct (structural model) effects of W to FC and F to WC on JS. Secondly, using mediation model, the indirect effects of WFB were calculated through W to FC, F to WC and JS.,Using convenience sampling, the data was collected from 280 academic people who work at private universities in Malaysia. Structural equation modelling technique was applied to complete the data analyses procedures.,The findings revealed that W to FC and F to WC have negative significant effects on JS. Besides, WFB partially mediates only the relationship between W to FC and JS while no mediation effect was found for F to WC and JS.,All the research variables in this study were individual-level variables, thus it is suggested to use some organizational and national level variables such as religion and culture as they might be good intervening variables for predicting JS.,Using the findings of this research, the Malaysian private universities community can take some necessary initiatives to mitigate work family conflict (W-FC) and ensure WFB and JS that might enhance the standard of higher education in Malaysia.,To the best of the authors' knowledge, this is the first attempt to test the mediation effect of WFB in the relationship between both directions of W-FC and JS of employees from the perspective of Malaysia (a collectivist community).


The field of toponymy in linguistics can fully reflect national knowledge, culture and folk traditions, socio-political changes and the historical picture. Toponymy is divided into several semantic groups. The scientific article discusses the names of toponyms created on the basis of one of these semantic groups-the names of species-flowers. The names of flowers are found in all areas of linguistics. Thanks to the cognition and perception of the surrounding world, various words, phrases, and symbol words have appeared in linguistics. Including color symbols have a different meaning in each vernacular. Kazakh toponymy, created on the basis of color names, is not only a set of names, but also a system of linguistic units reflecting national cognition. This is due to the fact that the names of flowers express a new meaning in the composition of the toponym and reflect its symbolic properties. The scientific article analyzes the toponyms found in the Abai region, their connection with color names. The semantic and linguistic analysis of the names of land-waters created in such shades as "white, black, blue, brown, red" was carried out. During the analysis, toponyms such as Akbaytal, Akzhal, Akshoky, Aktau, Koksung, Kokzhartas, Karabastaz, Karakol were considered. In accordance with the topic, scientific views and opinions of scientists were taken into account. The symbolic meaning of the names of flowers was shown.


This paper presents, analysis of magnetizing inrush current for different voltage angles and harmonic analysis of that inrush current using different FFT windowing techniques. Time domain simulations were used to solve the inrush phenomenon. Square, Welch, Hanning and Parzen windows were used to truncate the obtained inrush current harmonic spectrum for investigation and with parzen windowing the harmonic magnitude is getting reduced due to its reduced side lobes. Inrush current harmonic spectrum obtained by using FFT algorithm in turn discrete fourier transform. Out of different solvers to solve state equation, ode23t solver is used. For an unloaded single phase transformer, inrush current in time domain and harmonic content of inrush current were presented. The results are helpful to estimate harmonics effects in the transformer inrush currents. The results establish a guide line for harmonic elimination due to inrush current and offer an important reference for system design.


In May 2013, SSTI convened a Community of Practice meeting in Minneapolis focusing on the topic of, "Making the Most of the Transportation Alternatives Program Under MAP-21." Representatives of state DOTs and MPOs discussed their ideas and concerns with the new program under recently passed federal transportation legislation. Among the questions that emerged from the meeting was a desire for some guidance on performance measures for biking and walking investments. This paper is a result of that discussion and follow-up interviews with state DOT, MPO, and city transportation staff along with advocates for biking and walking, researchers, and consultants also concerned with this question.


Laser-induced fluorescence from nascent N/sup +//sub 2/(X /sup 2/..sigma../sup +//sub g/) ions produced by electron impact on a N/sub 2/ supersonic beam was observed. An analysis of the B /sup 2/..sigma../sup +//sub u/-X /sup 2/..sigma../sup +//sub g/ (0,0) band shows that the rotational state distributions cannot be represented by a single Boltzmann function, higher N'' levels being overpopulated. Experimental and analytical efforts were made to minimize the influence of cascading and relaxation on the rotational distributions. The rotational energy of N/sup +//sub 2/(X) thus estimated increases with decreasing electron energy from 2.26 +- 0.16 meV at 300 eV to 4.24 +- 0.27 meV at 25 eV. This trend is explained qualitatively in terms of angular momentum transfer through multipole electron--molecule interactions.


Provide a method and apparatus for a user equipment (UE) transmits a sounding reference signal (SRS) of. Receiving an indication having an aperiodic SRS aperiodic SRS transmission request field of a first downlink control information (DCI) format, the aperiodic SRS request field having a first value aperiodic SRS transmission parameters. Receiving a second indication DCI format aperiodic SRS transmission aperiodic SRS request field, the aperiodic SRS request field having a second value aperiodic SRS transmission parameters. The first aperiodic SRS transmission parameter value is compared with a second value aperiodic SRS transmission parameters. When the first and second values are the same, the aperiodic SRS transmission, and at the same time, does not transmit the aperiodic SRS transmission, when the first and second values no phase.


Good architectural acoustic design requires an appropriate combination of absorptive, reflective and diffusive surfaces, providing attenuation, redirection, and uniform scattering. Since the terms acoustical and absorptive have become synonymous in common parlance, education of the architectural design community is needed to understand the use of reflective and diffusive surfaces in spaces used for speech, music rehearsal and performance, and teaching. For example, in speech and teaching rooms, where the signal to noise ratio and associated intelligibility are the central issues, designs must not only lower the noise with absorption and isolation but also passively increase the signal with diffusion/reflection. In music education and rehearsal spaces, absorptive low frequency and volume control are important, but reflection/diffusion is equally important for ensemble, tone production and intonation control. In an effort to develop design guidelines, we will review the German standard DIN 18041 on "Acoustic Quality in small and medium sized rooms" (1968, 2004), which standardizes performance objectives in rooms with a volume up to 5000 cbm used for music, speech, and teaching. A frequency and volume dependent suggestion for the reverberation time will be presented as a function of the volume index and examples will be provided.Good architectural acoustic design requires an appropriate combination of absorptive, reflective and diffusive surfaces, providing attenuation, redirection, and uniform scattering. Since the terms acoustical and absorptive have become synonymous in common parlance, education of the architectural design community is needed to understand the use of reflective and diffusive surfaces in spaces used for speech, music rehearsal and performance, and teaching. For example, in speech and teaching rooms, where the signal to noise ratio and associated intelligibility are the central issues, designs must not only lower the noise with absorption and isolation but also passively increase the signal with diffusion/reflection. In music education and rehearsal spaces, absorptive low frequency and volume control are important, but reflection/diffusion is equally important for ensemble, tone production and intonation control. In an effort to develop design guidelines, we will review the German standard DIN 18041 on "Acousti...


This chapter covers several reverse engineering efforts for investigating networks of genes. Although our research is aimed primarily at signal transduction pathways composed of reactions between proteins, it is instructive to study genetic network techniques, in the hope that they will also be applicable to protein pathways. We first consider some of the differences between protein and gene networks. A graphical representation of a network consists of a set of nodes and a set of edges joining pairs of nodes. Let the nodes represent proteins in the case of a signal transduction pathway and genes in the case of a genetic network: what do the edges in each of the graphs represent? In the case of a gene network, there does not seem to be a specific meaning attributed to these connections. Generally, genes don't affect each other in a direct way, that is, they don't interact physically. An edge between two genes in a network really represents the idea that a change in the activity of gene A will cause some change in the activity of gene B. This change is the result of the transcription and translation of gene A and the subsequent activities of its gene product (possibly in a signaling pathway). An edge between two protein nodes represents a more direct connection, specifically that two proteins are involved in a chemical reaction. The form of this chemical reaction (a complex forming, a phosphorylation, a degradation) is not necessarily known, but actual physical effects are implied. In Chapter 4 it becomes evident that the fact that the edges of the graph have a specific nature affects the adaptation of these gene network methods to study protein interactions. Another important difference between gene and protein network determination is the available data. Because the effects of gene interactions are not directly transmitted, the time scale is much slower. Thus, current technology is capable of capturing adequate snapshots of the steps of the interactions. On the other hand, protein reactions occur within seconds and so many steps in a pathway may be carried out between measurements. This should also be taken into account when attempting to draw inferences about a series of connections between proteins. Despite these differences, it is advantageous to study the methods presented here. Both gene and protein networks are large, complex biological systems involved in regulating cell function. Also, most reverse engineering attempts of the kind …


Solutions to the equations describing traveling‐wave parametric amplification are presented. These results extend previous work by including the effects of momentum mismatch and general initial conditions (nonzero pump, signal, and idler fields) on the gain expressions. In contrast to statements found in some earlier published results it is shown that exponential growth is not required to achieve useful parametric gain. This fact is particularly important in the operation of continuously pumped optical parametric oscillators which operate with very small gain coefficients. The equations for the parametric gain are presented in general as well as for a number of limiting cases, and an optimum phase relation between the three waves giving maximum gain is found.


This chapter describes the exploration of the use of multidiemensional protein identification technology for the analysis of modereately complex polypeptide mixtures as resulting from affinity purification of protein complexes in a nonspecialized accademic laboratory setting. It was published as Graumann, J., Dunipace, L. A., Seol, J. H., McDonald, W. H. and Yates III, J. R. et al. (2004). Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Mol Cell Proteomics, 3(3):226–37. The copyright for the presented material is held by the American Society for Biochemistry and Molecular Biology, who has authorized its use in this work. The supplementary material referred to is available at http://www.mcponline.org/cgi /data/M300099-MCP200/DC1/1.


IT WAS ONLY SOME TEN YEARS AGO when Noam Chomsky still felt it necessary to caricature the theory of taxonomic (= Structural) linguistics to be, essentially, "nothing more than a summary of data" (1964:105). The issue, as well as the particular view expressed, was a familiar one, touching upon the meaning of data in scientific research. R. G. Collingwood, for instance, had discussed the twol types of scientific method: in what he termed the "pre-Baconian" science, "the first stage is to observe facts and the second stage is to ask what, if anything, they prove"; in the "post-Baconian" science, "the first stage is to ask a question and the second stage is to get it answered." (1962:278) As Chomsky put it,


This study aims to describe the views of other figures on homosexuality which are illustrated in Andy Stevenio's Love of Insecure novels. The data in this study are in the form of excerpts of stories in the novel. This study uses reading and technique notes. Data analysis using qualitative methods. The results of the study showed that there were several figures who accepted the perpetrators and rejected homosexual behavior, such as Mama Wira and Mama Wisnu the two figures both accepted the perpetrators but refused their behavior. Most people still accept homosexual behavior because it is related to human rights. However, on the other hand the community continues to accept homosexual behavior because it is contrary to trusted beliefs and customs. Then, there are also those who reject behavior as well as homosexuals like Papa Wira, schools and authors of their own stories. The form of rejection given is in the form of violence against the main character. This is consistent with what is in Indonesia because most homosexuals will be tried or treated harshly in the past. Until finally the Indonesian government formulated a law on LGBT so that LGBT perpetrators still get good treatment.


In August 2013, we celebrated the 50th Anniversary of the March on Washington and Dr. Martin Luther King, Jr.'s "I Have A Dream" speech. On August 28, 1963, over 250,000 people converged on the National Mall to fight for "jobs and freedom." A central demand of the marchers was the passage of meaningful civil rights legislation, including laws to end discrimination in voting and to free African Americans from the chains of "political and economic slavery."1 The march culminated with Dr. King's "I Have A Dream" speech in which he pronounced: "[w]e cannot be satisfied as long as the Negro in Mississippi cannot vote, and the Negro in New York believes he has nothing for which to vote."2 The Voting Rights Act of 19653 was passed just two years after the March, helping to usher in a new age of African American political participation. The Act's success is remarkable and undeniable. Indeed, its enactment was a turning point in "the struggle to end discriminatory treatment of minorities who seek to exercise one of the most fundamental rights of our citizens: the right to vote."4 But, the progress of the past 50 years has effectively come to a halt. The United States Supreme Court's decision in Shelby Cnty v. Holder5 is the latest and perhaps most potent attack on equal political participation. Shelby neuters one of the most effective tools in our arsenal against political repression, empowering jurisdictions to once again erect barriers to minority voting.6 Fifty years


The invention relates to an apparatus for generating and detecting a magnetization of a sample (103). The device comprises at least means (101) for providing a static magnetic field (102) of predetermined direction and intensity at a sample location, a transmitting device (104) for providing an additional magnetic field at the sample location and a receiving device (104) for detecting a magnetization of the sample (103 ). According to the invention it an array of at least two LC oscillators (104) whose oscillation frequency depends on the value of an inductive element of the LC-oscillators, which are frequency-synchronized through an interconnection, both as a receiving device (104) as well as a transmission device (104) as well as simultaneously used as a transmitting and receiving device (104). Means for driving the array (104) are connected, wherein satisfy the arrangement and the means for controlling (104) to generate a magnetic field which is able and deflect a magnetization of the sample (103) from an equilibrium position (the sample location in the near field of the array 104). downstream of the apparatus are means for demodulating (106), analog-to-digital converter and means for digital data processing (107) in a predetermined order, for processing an output voltage (105) of the array (104). Means for determining the magnetization of the sample and to be determined from spin concentration of individual spectral components and means for outputting the magnetization provided on the means for digital data processing (107).


Subsistance changes triggered by the climatic shift of the post-glacial period on the Japanese islands fostered the development of the Jomon culture and led to numerous changes in people's lives, including sedentarization. The development of the Jomon culture started with more active utilization of forest resources, which led to the development of new technologies and tools to exploit diverse resources. As a result, a variety of new subsistence-settlement systems flourished throughout the Japanese Islands. Among these was the Ento Pottery Culture in northern Tohoku, in which large-scale core settlements developed as early as the middle of the Early Jomon period. This culture is also charachterized by the presence of sophisticated ritual artifacts and features, as well as long distance exchange/trade. The Sannai Maruyama site is a good example of a core settlement from the Ento Pottery culture. Changes over time in occupational intensity of this settlement roughly coincide with the rise and decline of the Ento Pottery Culture. The excavation has provided useful information for understanding environmental conditions, as well as the susbistance activities, exchange/trade, rituals, and social organization of the site occupants.


Heme and non‐heme iron (Fe) are taken up by enterocytes via distinct transporters but may share the same exporter protein, ferroportin (FPN). The Fe regulatory hormone, hepcidin, controls non‐heme Fe absorption by inducing FPN degradation. Whether hepcidin affects heme Fe absorption is largely unknown. To address this question, we utilized stable Fe isotopes to measure heme and non‐heme Fe absorption in a rodent model of Fe overload. Male Sprague Dawley rats received bi‐weekly injections of PBS (control), 4 mg Fe (moderate Fe), or 12 mg Fe (high Fe) to induce Fe overload. After 2 weeks of treatment, rats were gavaged on alternate days with 57Fe as labeled ferrous sulfate and 58Fe as labeled porcine RBCs. Red cell incorporation of 57Fe and 58Fe was assessed 10‐days post‐dosing. Fe overload in rats increased Fe concentrations in liver (p=0.008) and spleen (p=0.002), increased levels of liver hepcidin transcripts (p=0.005), and reduced absorption of both heme (p=0.004) and nonheme Fe (p=0.01) by 69% and 63%, respectively. While humans absorb heme Fe more efficiently, non‐heme Fe absorption was 2.4‐times higher than heme Fe absorption in the rat (p=0.0009). Liver hepcidin had a greater association with non‐heme compared to heme Fe absorption (p=0.02, ANCOVA). Hepcidin up‐regulation in the rat inhibits both non‐heme and heme Fe absorption but suppresses heme Fe absorption less effectively.


We report the direct observation of internal layering in thin ({approximately} 45{endash} 90 {Angstrom} ) liquid films of nearly spherical, nonpolar molecules, tetrakis(2-ethylhexoxy)silane, using synchrotron x-ray reflectivity. The Patterson functions have secondary maxima indicating layer formation, and model-independent fitting to the reflectivity data shows that there are three electron density oscillations near the solid-liquid interface, with a period of {approximately} 10 {Angstrom} (consistent with the molecular dimensions). The oscillation amplitude has a strong inverse dependence on the substrate surface roughness. {copyright} {ital 1999} {ital The American Physical Society}


The blended wing body (BWB) is a tailless aircraft with the potential to use 27% less fuel than a conventional aircraft with the same passenger capacity and range. The primary purpose of the current study was to determine the handling qualities of the BWB, using piloted-handling trials in a moving-base simulator. The secondary purpose was to determine the eect of simulator motion on handling-quality ratings. De Castro conducted piloted-handling trials in a xed-base simulator. The current study uses much of the data from de Castro's work. Novel elements in the current study, apart from the use of simulator motion, include modied lateral-ight-con trol-system gains, modied engine moments, and the ground-eect model. Three pilots rated the longitudinal and lateral handling qualities as Level 1 or 2, depending on the task. Simulator motion did not have a signicant eect on the ratings.


Decreased testosterone (T) to LH ratio and increased 17β‐estradiol (E2) serum concentrations represent a common finding among patients with severe spermatogenic failure, suggesting a concurrent Leydig cell steroidogenic dysfunction. Aromatase overexpression has been associated with increased serum and intratesticular E2 in these patients. However, it is unknown whether the sulfatase pathway contributes to the increased availability of active estrogens in patients with primary spermatogenic failure.


The smallest measurable improvements in efficiency can make the difference between winning and losing a solar-powered car race across Australia


Parametric properties provide an effective and natural means to describe object-oriented system behaviors, where the parameters are typed by classes and bound to object instances at runtime. Efficient monitoring of parametric properties, in spite of increasingly growing interest due to applications such as testing and security, imposes a highly non-trivial challenge on monitoring approaches due to the potentially huge number of parameter instances. Existing solutions usually compromise their expressiveness for performance or vice versa. In this paper, we propose a generic, in terms of specification formalism, yet efficient, solution to monitoring parametric specifications. Our approach is based on a general algorithm for slicing parametric traces and makes use of {\em static} knowledge about the desired property to optimize monitoring. The needed knowledge is not specific to the underlying formalism and can be easily computed when generating monitoring code from the property. Our approach works with any specification formalism, providing better and extensible expressiveness. Also, a thorough evaluation shows that our technique outperforms other state-of-art techniques optimized for particular logics or properties.


THERE is an old saying that before you can cook your hare you must first catch it. The stressman might interpret this as "before you can stress a redundant frame you must first find the redundancy".


La Nina is a climate anomaly that can cause extreme weather. La Nina is marked by a decrease in the sea surface temperature of the Pacific Ocean at the equator. La Nina can cause a prolonged rainy season for Asia including Indonesia. From mid-2020 to the end of 2022, Indonesia has experienced La Nina events. This study aims to determine changes in rainfall patterns and the number of rainy days during La Nina events. This research was conducted descriptively, using Pacific Ocean sea surface temperature (SST) data and rain data originating from the BMKG Climatology Station of Sultan Syarif Kasim II Pekanbaru from data for the last 10 years 2013-2022. The results of the study show that La Nina occurred from October 2020 to December 2022 with a weak to moderate level of La Nina strength. La Nina has increased the amount of rainfall 54-90% from normal conditions and increased the number of rainy days 11-70% compared to climate with normal conditions. Monthly rainfall is in the low to high category, while daily rainfall is included in the heavy rain category. The La Nina event has caused a prolonged rainy season for almost 3 years and has increased the amount of rainfall and rainy days.


Objective To study the expressions of hypoxia inducible factor (HIF)-1 and angiopoietin (Ang)-2 in repeated gastrointestinal bleeding due to vascular malformation, and the efficacy of treatment with thalidomide. Methods Twenty-five patients with repeated gastrointestinal bleeding due to vascular malformation confirmed by capsule endoscopy or enteroscopy were collected and 18 subjects without severe diseases were served as controls. Ten patients with gastrointestinal vascular malformation, who received 25 mg of thalidomide 4 times daily for 4 months and were followed up for at least one year, were also enrolled. The serum samples from all participauts were detected for expressions of HIF-1 and Ang-2 using enzyme-linked immunosorbent assay (ELISA).The expressions of HIF-1 and Ang-2 were compared between angiodysplasia group and control group.The expressions of HIF-1 and Ang-2 were comparatively evaluated before and after treatment with thalidomide in treatment group. Results The expressions of HIF-1 and Ang-2 in vascular malformation group [( 113. 84 ± 26. 66 ) ng/ml and ( 652. 11 ± 140. 39) ng/ml, respectively] were significantly higher than that of control group [(43.28±17.30) ng/ml and (265.60±53.88) ng/ml,respectively, P=0. 000]. The expression of HIF-1 was positively associated with that of Ang-2. (r=0. 700, P= 0. 000). There was no difference in expressions of HIF-1 and Ang-2 before and after treatment with thalidomide (P=0. 498 and =0. 136, respectively). However, significant reduction of Ang-2 [(113. 80±73. 60) ng/ml(P=0. 003)] was found in 8 effectively treated patients after thalidomide treatment. Conclusions HIF-1 and Ang-2 might play an important role in the formation of vascular malformation. The extent of Ang-2 reduction after thalidomide treatment may be helpful in evaluating its efficacy or prognosis.

Key words:
Obscure gastrointestinal bleeding;  Vascular malformation;  Angiodysplasia;  Hypoxia inducible factor -1;  Angiopoietin-2


Abstract Elder mistreatment (EM) is a growing public health and safety crisis, with long-term consequences for individuals, families, and communities. We explored whether older adults hospitalized with a primary diagnosis of EM was associated with an increased risk of mortality and unplanned hospital readmission compared to those with a secondary EM diagnosis. We further examined whether EM type and hospital setting was associated with risk of mortality and unplanned hospital readmission. Using 100% of 2015-2018 Medicare files of hospitalized Medicare Fee-for-Service beneficiaries aged 66 and over, we used Kaplan-Meier and Cox proportional hazard models to estimate mortality and unplanned readmission rates by primary versus secondary EM diagnosis, EM type, and facility type. 11,023 patients were hospitalized with an EM diagnosis. The majority were female (64.1%) and Non-Hispanic/Latinx White (74.3%). Neglect was the most common EM type. The three-year mortality rate was 56.7% and one-year readmission rate was 53.8%. Compared to other EM types, patients diagnosed with neglect had a 2.20 (95% Confidence Interval [CI]=1.88-2.56) and 3.21 (95% CI=2.32-4.43) times greater risk for mortality within and after 50-days from discharge, respectively. Patients discharged from a skilled nursing facility (SNF) were at an increased risk of mortality and unplanned readmission compared to those discharged from an acute hospital. Hospitalized patients with a primary EM diagnosis were associated with an increased risk of mortality and readmission compared to those with a secondary diagnosis. Future work should explore care patterns before and after EM diagnosis to identify potential time points for medical and social intervention.


Conn (1942) observed that Alcaligenes faecalis required organic nitrogen, but as observed by Porter (1946) no report was found of a study of nitrogen compounds suitable for continued growth of A. faecalis. It was reported, however, that this organism grew in a medium containing NH4 lactate as a source of nitrogen and carbon (Braun and Cahn-Bronner, 1921), and used NH4NO3, asparagine, cysteine, and Na pyruvate (Berthelot and Amoureux, 1938). Accordingly, a study of utilization of 39 common organic and 3 inorganic compounds is reported.


Rate-splitting multiple access (RSMA) combines the concepts of non-orthogonal multiple access (NOMA) and space-division multiple access (SDMA) to provide higher sum-rates (SRs). In particular, one-layer RSMA splits the users' message into two parts: a single common message for all users and a private message for each user. In this work, we consider the problem of maximizing the downlink (DL) energy efficiency (EE) for one-layer RSMA subject to specific quality of service (QoS) constraints and under consideration of a single-input single-output (SISO) system. The solution to this multi-objective problem depends on finding: i) the optimal DL transmit powers, ii) the optimal rate allocation, and iii) the optimal radio frequency (RF) transmit power that must be selected by the base station (BS) so as to obtain the best EE. Thus, we decouple the original problem into three sub-problems that find each part of the solution sequentially. We take advantage of an earlier solution available in the literature for the first two decoupled sub-problems and extend it to an algorithm that maximizes the EE. Numerical results demonstrate consistent performance bounds of our proposed algorithm to the optimal EE values, comparing them to NOMA and orthogonal multiple access (OMA) solutions.


Objective To study the manifestations of the pericardial sinuses on axial spiral CT scans in comparison with sectional anatomy, and to evaluate its imaging significance.Materials and Methods Axial spiral CT findings of the mediastinum in 52 patients with pericardial effusion (effusion group) and 146 subjects without pericardial effusion (control group) were reviewed. Comparing with the sectional anatomy in two cadavers, the display rate of the sinuses and recesses on 5 main axial CT slices was analyzed statistically.Results The display rate of the sinuses and recesses was over 40% and no significant difference was found between small, moderate and large effusion group (P0.05). No significant difference in the display rate of PCR, RPR and pSAP existed between effusion group and control group (P0.05), except for the others (P0.05).Conclusion Pericardial sinuses and recesses can be easily detected on spiral CT scans. The localizing diagnosis is depended on the relative sectional anatomic knowledge. The pericardial sinuses and recesses should be differentiated from the adjacent normal structures as well as diseases.


It has been demonstrated that the hot stagnation region formed during the collision of laser-produced carbon plasmas is rich with carbon dimers which have been shown to be synthesized into large carbon macromolecules such as carbon fullerene onions and nanotubes. In this study, we developed and integrated experimental and multidimensional modeling techniques to access the temporal and spatial resolution of colliding plasma characteristics that elucidated the mechanism for early carbon dimer formation. Plume evolution imaging, monochromatic imaging, and optical emission spectroscopy of graphite-produced, carbon plasmas were performed. Experimental results were compared with the results of the 3D comprehensive modeling using our HEIGHTS simulation package. The results are explained based on a fundamental analysis of plasma evolution, colliding layer formation, stagnation, and expansion. The precise mechanisms of the plasma collision, plume propagation, and particle formation are discussed based on the exper...


Since 1999, the Township of Millburn has required dry wells to accommodate additional flows from newly developed areas in order to mitigate local drainage and …


With looming water scarcity, sustainable water sourcing and management has generated a significant amount of interest over the recent years. In this study, an integrated framework for water sourcing and management for the oil and gas industry is presented, as it is going to be critical to meet future growth in water demand from a technical and commercial perspective. In addition, the results are augmented with extensive literature survey of current methodologies and innovative management solutions that will greatly assist in the water sourcing and challenges for a given region. The framework presented in this study provides a unique perspective of oil and gas field life cycle analysis, to allow real time decision making and maintain uninterrupted water delivery at reduced cost. The framework allows to build a platform cross sectors for integrated technology development across industrial, private and public sectors.


The relevance of the topic is due to the lack of a unified point of view regarding the separation of the judicial service into an independent type of public service due to the lack of elaboration of this issue. As a result of the analysis of the scientific literature on the problems of the formation of types of public service, using the formal-logical method and hermeneutics, the author formulates conclusions according to which the only necessary and sufficient criterion for justifying the separation of the judicial service into an independent type of public service is the purpose of the judicial service, which consists in ensuring the independent and independent execution of the constitutional powers of a judge by committing organizational, technical and procedural actions, provided for by the norms of procedural law, which means that a separate federal law on the organization of this service should be adopted. Determining the status of the judicial service as an independent type of public service is a logical continuation of judicial reform and the next step in ensuring the independence of judicial authorities.


Abstract While the beneficial impact of positive social relationships on health is well–documented, recent research suggests that family–of–origin relationships can also impact health and physiological responses to stress later in life. Animal studies have shown that the impact of adverse caregiving extends beyond physical health outcomes to exert a long–term effect on cognitive performance. Human studies have related early family adversity to long–term physical health, but have not yet evaluated age–related cognitive outcomes. The current paper considers evidence for a model proposing that early family adversity such as abusive or neglectful parenting can impact cognitive performance in older adulthood through psychosocial, behavioral, and health–related pathways operating across the lifespan. Evidence to support each pathway is discussed, along with limitations and directions for future research.


The growing popularity of mobile devices gave birth to a still emergent research field, called Mobile Music (music with mobile devices). Our particular research investigates such repurposing of ordinary mobile devices for use in musical activities. In this paper we propose the use of patterns in the design of musical interaction with these devices. We introduce the musical interaction patterns that came out of our investigation so far, and describe the exploratory prototypes which served as inspiration and, at the same time, as testbed for these proposed interaction patterns.


ABSTRACT One ovigerous female of Dasella herdmaniae (Lebour) is reported from Inhaca Island, southern Mocambique. It is the most southern and also the most western report from the Indian Ocean. The specimen exhibited minute hepatic spines and 2 terminal and 1 subterminal "clubshaped" spines on the ambulatory pereiopods. A new species, Dasella brucei, is established for the specimens of D. herdmaniae reported from Heron Island, Great Barrier Reef, Australia.


The present invention relates to a noodle robot disc holder surface leveling device, comprising a rotating mechanism, the rotation mechanism includes a robot wrist, and a drive system for a base plate of the bearing holder surface; base end of the robot wrist hinge, the other drive system drives the base hinged at one end to the base of the robot wrist axis is rotated. The adjusting means can be easily adjusted to achieve an angle between the face plate holder inclined position and a horizontal position.


In this paper, we contruct Hilbert C* -bimodules for continuous graphs whose vertexes are countable 1-dimensiona tori, and show some uniquness property of the C* -representatiion of these bimodules.


The research aims to explore if and how the administration of cases is affected by the social workers knowledge of honour related violence and oppression (HRVO), and by the social workers definitio ...


In the oral tradition of rural north India, especially the Haryana region, hegemonic masculinity emerges as an ideological construct in the structure of patriarchy firmly located in materiality. This creates and consolidates male power over various categories of people and highlights several hierarchies of masculinities, caste, class, and gender, including those between males and females as well as those between males and males. The oral tradition, which includes folktales, myths, folk songs, popular sayings, and proverbs, enjoys a common currency of social interaction among a wide range of social groups. Together these have been evaluated to provide valuable insights into how masculinities are perceived, lived, or practiced at the local level, and molded or remolded in response to the socioeconomic shifts that are taking place. However, in this region there is also a contrary imaging of masculinity that demolishes all that is regarded as the hallmark of hegemonic masculinity. Registered in women's folk songs, this imaging is considered a threat to male power, authority, and what is perceived to be "masculine." All attempts by upper caste males to censor these songs or replace them have been unsuccessful, thereby highlighting the ongoing contradiction and contest around the concept of masculinity itself.


Introduction:
 Elevated blood levels of lipoprotein(a) [Lp(a)] are an independent causal risk factor for atherosclerotic cardiovascular disease. Lp(a) particles are formed by a lipid domain and an apolipoprotein B (apoB) protein that is bound to apolipoprotein(a). Standard low-density lipoprotein cholesterol (LDL-C) and ApoB lowering treatments have minimal Lp(a)-lowering efficacy. We have previously shown that AZD8233 inhibits hepatic PCSK9 synthesis and causes substantial reductions in LDL-C. Here we report the significant effects of AZD8233 on Lp(a) and ApoB.

 Methods:
 ETESIAN was a multicenter phase 2b, randomized, double-blind, placebo-controlled, dose-ranging study (NCT04641299). Eligible participants were 18-75 years old, on statin therapy, with LDL-C of ≥ 70 to < 190 mg/dL, and with fasting triglycerides of < 400 mg/dL. Participants were randomized 1:1:1:1 to subcutaneous injections (days 1, 8, 29, and 57) of either 15, 50, or 90 mg AZD8233, or placebo. The primary objective was to evaluate the effect of AZD8233 versus placebo on LDL-C at week 12. Secondary objectives were to assess Lp(a) levels and other lipid parameters.

 Results:
 A total of 119 patients were enrolled in ETESIAN. AZD8233 was well tolerated and demonstrated dose-dependent and clinically meaningful reductions in LDL-C, Lp(a), and ApoB (
 Table
 ). The relative distribution of these effects across participant subgroups and the interaction of effects on Lp(a), ApoB, and LDL-C will be presented.

 Conclusion:
 In patients with dyslipidemia on statins, AZD8233 caused substantial reductions in LDL-C and Lp(a), two independent risk factors for major adverse cardiovascular events. The broad lipid-modifying effect of AZD8233 may, hence, provide an opportunity to reduce cardiovascular risk in patients with ASCVD beyond currently available medications.


Numerous flood disaster mitigation and prevention structures were built by Water Resources Agency(WRA) for improving the watershed management in Taiwan,including banks,drainage systems and pumping stations.Due to the changes of land exploitation in many major watersheds,the original designs for these structures are incapable to achieve flood prevention objectives.Recently,inundation areas for most of rivers in Taiwan have been delineated to provide information by nonstructural measures for floodplain management.The main purpose of this study is to establish the inundation index by Analytic Hierarchy Process(A.H.P.) method,which can provide quantifiable information to assess the construction efficiency of the flood structures and to support the decision making of the flood emergency responds.


In current generation digital phase locked loop (DPLL) architectures, techniques like adaptive loop bandwidth with loop order switching and switched phase-detection are employed to achieve better lock time and jitter performance. This work derives stability conditions for such DPLL architectures using Multiple Lyapunov Functions (MLFs) for switched systems. The loop-parameters chosen on the basis of these stability conditions ensure that chattering phenomenon does not occur during switching between different subsystems. A 5GHz fractional-N DPLL designed with these loop-parameter values is fabricated in CMOS65nm-LL technology. The measured settling time of the implemented DPLL is within 1us. The efficiency of switching rule and stability conditions used for this DPLL is validated with the fast settling response, which is the best lock time reported until now for fractional-N DPLLs.


V J A new experience On 13th April, 1973, I became a play therapist for the first time. I was then nearing the end of my 45th year of life, and although I had notched up a few years of experience as a PSW in psychiatric placements, both residential and outpatient, for normal, intelligent and retarded children, my contact had been predominantly with parents — all quite traditional social work. Ten years had intervened: ten years of domestic pastimes, during which I had experienced the satisfaction of renovating beach houses and constructing gardens in my own style.


In this paper, we study an online sampling problem of the Wiener process. The goal is to minimize the mean squared error (MSE) of the remote estimator under a sampling frequency constraint when the transmission delay distribution is unknown. The sampling problem is reformulated into a renewal reward optimization problem, and we propose an online sampling algorithm that can adaptively learn the optimal sampling policy through stochastic approximation. We show that the cumulative MSE regret grows with rate O(ln k), where k is the number of samples. Through Le Cam's two point method, we show that the worst-case cumulative MSE regret of any online sampling algorithm is lower bounded by Ω (ln k). Hence, the proposed online sampling algorithm is minimax order-optimal. Finally, we validate the performance of the proposed algorithm via numerical simulations.


ABSTRACT Risperidone is one of the most commonly used antipsychotic agents in the treatment of psychosis in children and adults. However, it can lead to hyperprolactinaemia by blocking dopamine D2 receptors in the anterior pituitary. This can result in galactorrhea, menstrual irregularity, amenorrhoea and gynaecomastia and can impact adversely on medication compliance and quality of life. Very few data are available in the literature concerning the management of hyperprolactinaemia developing in association with antipsychotics in children and adolescents. This report describes improvement with the addition to treatment of low-dose aripiprazole in hyperprolactinaemia and menstrual irregularity emerging as side effects of risperidone therapy in an adolescent girl diagnosed with schizophrenia.


BACKGROUND
 The majority of children are insufficiently physically active. The interest in video games amongst children provides new opportunities to increase physical activity (PA) via exergames. Tailoring exergames is costly and labor intensive and therefore the implementation of an exergame with minimal support could be promising. The exergame BOOSTH uses a wrist worn activity tracker to measure steps per day. As a reward for the performed PA, children can unlock levels in the online BOOSTH game. In addition, the BOOSTH battle enables competition between groups.

 OBJECTIVE
 The current study aims to investigate the effect of the exergame BOOSTH, implemented in the primary school setting, on PA, sedentary time (ST), screen time and motivation towards PA after three and six months.

 METHODS
 The study was a cluster randomized controlled trial. Stratified by community and school size, sixteen primary schools were randomized into standard physical education curriculum (control) or standard physical education curriculum + BOOSTH (intervention). Measurements were performed at baseline and after 3 and 6 months. PA (total PA, light PA and moderate to vigorous PA (MVPA)) and ST were measured with the GT3X Actigraph accelerometer and the BAECKE questionnaire. Motivation towards PA was measured with the BREQ-2 questionnaire. Data were analyzed using linear mixed models.

 RESULTS
 710 children (53% girls, 10 ± 1y of age) participated in this study. After correction for baseline levels/data, children in the intervention group had on average a lower MVPA (min/day) (effect estimate B= -10, p= <0.001) and higher ST (min/day) (B= 24, p= 0.002) at six months compared to the control group. After six months, children in the intervention group reported lower intrinsic motivation towards PA (B= 0.27, p = 0.011) and higher screen time on a weekday (B= 0.033, p = 0.045) compared to the intervention group. Sensitivity analyses showed similar results.

 CONCLUSIONS
 Implementation of the exergame BOOSTH in the primary school setting had adverse effects on promoting PA and reducing ST in daily life of children in the first half year. A mixed method process evaluation is needed to gain a more complete understanding of the (un)successful implementation components, and to identify recommendations for future exergame interventions in
the school setting.

 CLINICALTRIAL
 ClinicalTrials.gov, NCT03440580, https://clinicaltrials.gov/ct2/show/NCT03440580.

 INTERNATIONAL REGISTERED REPORT
 RR2-10.2196/24035


Photograph of two attendees after the Sigma Tau Delta induction on April 27, 2007. They are taking a picture together in front of a display.


OBJECTIVE: To study the prevalence of osteoporosis and osteopenia in patients seen in an academic neuromuscular clinic in central Pennsylvania.
BACKGROUND: Osteoporosis (OP) and osteopenia are largely under-diagnosed conditions. Scattered reports of prevalence of osteoporosis in patients with Duchenne muscular dystrophy, SMA, ALS, Dermatomyositis and polymyomyositis, and post-polio syndrome have been published. A mouse model study of osteoporosis has shown progressive trabecular bone loss with progression of neuromuscular conditions. A Canadian multicenter osteoporosis study showed a prevalence of OP in men over 25 to be 6.6[percnt] and that for women over 50 years of age to be 15.8[percnt]. Such data for OP and osteopenia for patients seen in adult neuromuscular clinics in the US are lacking.
METHODS: 27 consecutive adult patients, seen after random selection,had baseline bone mineral density (BMD) testing done from L spine and femur-neck. These patients were those who were considered for oral prednisone therapy. Among he paients, sixteen were women, and eleven men.
RESULTS:6 patients had osteoporosis (22[percnt]); 8 had osteopenia (30[percnt]), and 13 had normal (48[percnt]) BMD testing. Six out of eleven men and eight out of sixteen women had abnormal testing. The prevalence of osteoporosis/osteopenia was statistically significant for both the gender groups.
CONCLUSION; This PILOT study showed a statistically significant high prevalence of osteoporosis and osteopenia in patients with neuromuscular disorders independent of any known long term similar effects of prednisone therapy.such high prevalence was seen in men as well as in women.Large multicentric studies are worth contemplating. This can turn out to be an undiagnosed endemic or even pandemic condition. Plummeted quality of life, pain, and fractures can result from osteoporosis which can be potentially preventable if accurate and holistic diagnoses are made, prompting appropriate measures.
Study supported by: none Disclosure: Dr. Bandyopadhyay has nothing to disclose.


PWR Core II fuel pool chiller-off test was conducted because it appeared possible that acceptable pool-water temperatures could be maintained without operating the chillers, thus saving hundreds of thousands of dollars in maintenance and replacement costs. Test results showed that the water-cooling capability is no longer needed to maintain pool temperature below 38{degrees}C (100{degrees}F).


DiSL is a new domain-specific language for bytecode instrumentation with complete bytecode coverage. It reconciles expressiveness and efficiency of low-level bytecode manipulation libraries with a convenient, high-level programming model inspired by aspect-oriented programming. This paper summarizes the language features of DiSL and gives a brief overview of several dynamic program analysis tools that were ported to DiSL. DiSL is available as open-source under the Apache 2.0 license.


The major thrust of planned development in India has been on employment and income generation and self‐reliance. The study evaluates ex‐post income, output and employment linkages and import intensities of manufacturing sectors using an input‐output model. It shows that among the four broad groups of industries, namely agrobased, non‐agrobased final goods, intermediate and capital goods, agrobased industries through technological interdependence, particularly backward linkages, generate relatively more income and employment and use less imported inputs. The non‐agrobased final goods industries with larger import requirements provide potential for income and employment generation if their required imported inputs are internalised.


Understanding the chip formation process and the loads that the tools are subjected to in intermittent cutting operations of stainless steel are of importance in order to increase the span of the t ...


[PDF]  [Full Text]  [Abstract] , September 1, 2013; 115 (5): 756-764. J Appl Physiol Bamman Ceren Yarar-Fisher, C. Scott Bickel, Samuel T. Windham, Amie B. McLain and Marcas M. men and the effects of contractile activity Skeletal muscle signaling associated with impaired glucose tolerance in spinal cord-injured [PDF]  [Full Text]  [Abstract] , October 3, 2013; . European Journal of Preventive Cardiology Johan Sundström Kasper Andersen, Lars Lind, Erik Ingelsson, Johan Ärnlöv, Liisa Byberg, Karl Michaëlsson and Skeletal muscle morphology and risk of cardiovascular disease in elderly men [PDF]  [Full Text]  [Abstract] , February 1, 2014; 306 (3): E275-E283. Am J Physiol Endocrinol Metab Veeraj Goyaram, Tertius A. Kohn and Edward O. Ojuka Suppression of the GLUT4 adaptive response to exercise in fructose-fed rats [PDF]  [Full Text]  [Abstract] , September 1, 2014; 117 (5): 544-555. J Appl Physiol Gardiner, Patricia Sheppard, Teri L. Moffatt and Todd A. Duhamel Marc P. Morissette, Shanel E. Susser, Andrew N. Stammers, Kimberley A. O'Hara, Phillip F. reticulum calcium-ATPase isoforms induced by exercise training Differential regulation of the fiber type-specific gene expression of the sarcoplasmic [PDF]  [Full Text]  [Abstract] , February , 2015; 22 (2): 231-239. European Journal of Preventive Cardiology Johan Sundström Kasper Andersen, Lars Lind, Erik Ingelsson, Johan Ärnlöv, Liisa Byberg, Karl Michaëlsson and Skeletal muscle morphology and risk of cardiovascular disease in elderly men


Demographic Profiles U.S. Hispanics: Changing the Face of America by Cary Davis, Carl Haub, and JoAnne L. Willette New York Hispanics: A Demographic Overview by Douglas T. Gurak Immigration, Assimilation, and Cultural Identity From Settlers to Newcomers: The Hispanic Legacy in the United States by Edna Acosta-Belen Telling Hispanics Apart: Latino Sociocultural by J. Jorge Klor de Alva Migration and Identity: A Comparison of Puerto Rican and Cuban Migrants in the United States by Helen I. Safa Latinismo among Early Puerto Rican Migrants in New York City: A Sociohistoric Interpretation by Virginia Sanchez Korrol Culture Contact and Value Orientations: The Puerto Rican Experience by Barbara R. Sjostrom Spanish in the United States by Arnulfo G. Ramirez Socioeconomic Profiles The Unrecognized: Mexican Immigrant Workers and America's Future by James D. Cockcroft The Changing U.S. Mexico Border Region: Implications for the Hispanic Labor Force by Gilbert Cardenas Bibliography Index


German constructions with the verb prefix be- do not just alternate with simple-verb constructions that express a "goal" argument obliquely; they can also contrast with simple-verb constructions in which the "goal" argument appears as an accusative incremental theme. By focusing on these contrasting constructions we can distinguish the semantic contribution of be- from the meaning of the transitive construction itself, enabling a cognitive-semantic account of be-verb constructions that differs significantly from previous proposals. Be- describes a sustained (and typically iterative) interaction directed at a focal accusative landmark whose existence is independent of the event being described. In the process of examining be- verbs we can also gain a better understanding of incremental themes and of "holistic effects". The discussion also has general implications for the semantics of argument roles, challenging the idea that semantic roles are global units that can be transported from one construction to another.


PURPOSE: A system for managing resources and limitation is provided to manage the limitation of an open market, thereby offering an illegal payment prevention function and a limitation management function. CONSTITUTION: A system comprises an operation manager server, an application server, an interface server, and a database server. A client requests available money through a web browser in order to search and purchase a product by connecting an open market by using a client terminal. A limitation management unit of an integrated limitation management system (900) transmits the remaining limitation to the client terminal through the interface server and supports the payment according to the purchase of the corresponding product. [Reference numerals] (900) Integrated limitation management system (RCM); (AA) Phone bill payment; (BB) Customer limit management; (CC) Google DCB; (DD) Olleh market; (EE) Purchase request; (FF) Purchasable amount of money (residuary limit) request; (GG) Transmit residuary limit; (HH) Interlock customer information; (II) SDP integrated profile; (JJ) Limit policy management mean; (KK) Set limit per service and customer state; (LL) Exemption target information management (product/calling rate/customer...; (MM) Policy rate management; (NN) Cheating-payment management; (OO) Interface server; (PP) Provide KHUB limit OPEN API service; (QQ) Limit management mean; (RR) Limit payment/deduction/accumulation management; (SS) Limit cancel amount management; (TT) Limit control management; (UU) Cheating-payment management per payment pattern; (VV) Provide statistic information


The rates of Isospora infection in mink youngsters aged 1-3 and 3-6 months as well as in adult animals appeared to be 16,2; 12,7 and 11,5% respectively; the same indices for Eimeria infection were 3; 13,6 and 15,3% in the Moscow Region. The rates of infections in conditions of the Tverskaya Region ranged 7,4 to 9,1%.


In the sixteenth century, witchcraft was generally thought to be a grave danger. Specific people, a majority of them women, were believed to threaten the world as servants of the Devil. In his De praestigiis daemonum, published in 1563, the Dutch / German physician Johan Wier argued that human beings were unable to perform witchcraft and that the women who were accused were innocent but often deluded by demons into believing that they were guilty. In his plea for tolerance Wier was inspired by his brother Matthias and the spiritualist prophet David Joris. In order to convince his readers he used their prejudices, that he himself rejected, about the power of demons and the intellectual capacities of women.


The purpose of this study is the first writer to see a reporter effective field generally requires a range of capabilities, especially regarding public knowledge.Basically very strict journalistic standards: journalists must decide honestly and ethically, facts collected a fair picture of reality and accurate or even vice versa, It is the duty of journalists although it looks heavy, start from the smallest thing to seek to provide an honest public consumption will show you how to work in a professional journalist
This study was to find out how to perform management Malang Post investigative news coverage so as to provide input to the investigative news reporting team and Malang Post to be better coordination
Researchers use this type of research deskripstif through a qualitative approach. Data collection methods used were interviews and documentation. The subjects of this research, the journalist who has worked at least three (3) years as a journalist, the status of staff, stringers or editor, has a competent education.
The results showed that at the stage of planning and research implemented by the project leader or coordinator, which then results of the research will be communicated to reporters. Based on interviews known that the communication of research results to journalists who would jump field is not maximal dikarena briefing that little time causing less understood journalists reporting region. Journalists only understand about what tasks will be carried out as directed by the project leader. On the way down the field coordination between the project leader and journalist quite well because every night after coverage of an evaluation. The results of the investigation of news coverage in Malang Post must bring a solution that is not only a problem just raised so Malang Post to encourage the parties - the authorities to address the issues that have been raised to the surface. In coordination is expected at the time of the communication stages of research results to journalists as executor given enough time. So that journalists can learn the results of research and the areas to be covered in order to achieve maximum results in news coverage of the investigation.
,

Approved,
 Supervisor I Supervisor II

Farid Rusman, Drs. M.Si Nurudin, S. Sos, M.Si


ABSTRACT Should refugees receive political rights in liberal democracies? I argue that they should. Refugees are special – at least when it comes to claims towards democratic inclusion. They lack exit options and are significantly impacted by decisions made in liberal democracies. Enfranchisement is a matter of urgency to them and should occur on a national level. But what justifies the democratic inclusion of refugees? I draw on the all-subjected principle in arguing that all those subjected to rule in a political unit should have a say in such rule. I show that refugees cannot be denied democratic inclusion based on the argument that transients should be excluded from participation. Refugees are not transients. Finally, I show that naturalization is not a prerequisite for enfranchisement. Political rights and citizenship can be had independently of each other. Refugees, then, should be nationally enfranchised as soon as they receive refugee status.


Purpose: Although the contents of the six-year undergraduate medical curriculum have been discussed, the details about how Postgraduate General Medical Training should be executed have not been finalized. Because the medical education reform in Taiwan may move towards six-year undergraduate curriculum plus two-year postgraduate general medical training, it is very important to borrow experiences from the United Kingdom and Japan, which both have six-year undergraduate curriculum and two-year postgraduate training before entering specialty and subspecialty training. Methods: A part-time interpreter was recruited for searching materials in relation to Basic Clinical Training written in Japanese. A research assistant was responsible for searching the web page of Foundation Program under the supervision of one of the investigators, and the search results were further examined and confirmed by the investigator. Both of them were given detail introductions regarding Japan's Basic Clinical Training and the United Kingdom's Foundation Program, as well as data collection sheets addressing the following issues: (1) history; (2) curriculum; (3) assessments. Results: The results of this present study provide a good opportunity for comparing the curriculums and assessments in Basic Clinical Training and Foundation Program with those in Taiwan's Postgraduate General Medical Training. Conclusion: By further deliberating Foundation Program and Basic Clinical Training, the followings are highly suggested for the future Postgraduate General Medical Training in Taiwan: (1) allowing more flexibility for trainees to determine the curriculum of Postgraduate General Medical Training; (2) the reliability and validity of assessment tools being evaluated for providing convincing assessment results both to trainees and raters.


Abstract In the present, paper the simulation of XRD data by modified Arrhenius and Lorentz equations has been proposed for the first time which is new. The trial of simulations have been performed on ferroelectric ceramics [Ba(Nd0.1Ti0.8Nb0.1)TiO3]1-x[Na0.5Bi0.5TiO3]x (x = 0.25), Na(0.5-x)KxBi(0.5-x)DyxTiO3 (x = 0.0125) and (Ba0.997Nd0.003TiO3)+5% SiO2. The simulations performed on the above ceramics are in good agreement with the experimental data. Using the modified Arrhenius and Lorentz equations, we obtained the lattice parameters for the ceramic samples having cubic, rhombohedral and tetragonal symmetry. In addition to the lattice parameters, the activation energy for diffraction has also been evaluated. The simulations of XRD data using Arrhenius and Lorentz equations can also be extended to other compounds with different crystal symmetry.


The prevalence of type 2 diabetes mellitus (T2DM) has been increasing at an alarming rate. With an increased understanding of the pathophysiology of T2DM, various new therapeutic options have been developed and evaluated to bind different key targets in T2DM. The discovery of novel therapies through many approaches such as unprecedented drug combinations, modified drug molecules, and improved delivery systems can nullify some of the undesirable side effects of traditional agents, in addition to enhancing their effectiveness. Newer drug targets such as protein kinase B (Akt/PKB), AMP-activated protein kinase (AMPK), sirtuin (SIRT), and others are novel approaches that act via different mechanisms and possibly treating T2DMof distinct variations and etiologies. Other therapies such as end barrier, gene therapy, and stem cell technology utilize advanced techniques to treat T2DM, and the potential of these therapies is still not well explored. Molecular targets in T2DM are also extensively studied as they could target the defects at the molecular level. In this regard, antibody therapies and vaccinations are also developed against T2DM; however, the ongoing clinical trials are scanty, and the developmental progress is slower. There are many therapies designed to cure T2DM, each of them has its advantages and disadvantages. The preference for the treatment plan usually depends on the health status of the patient and the treatment goal. To consider an ideal treatment option, one should worry about many factors. These include patient compliance, drug efficacy and potency, bioavailability, and other pharmacological and non-pharmacological properties among others.


From 29–31 August 2013, the 1st International Conference on Light and Particle Beams in Materials Science, LPBMS 2013, took place in the Tsukuba International Congress Center in the city of Tsukuba, Japan. The conference was a continuation of the international series Synchrotron Radiation in Materials Science (SRMS), which started in 1994. The last one, SRMS-7, was held in Oxford UK 11–14 July 2010, where the International Advisory Committee (IAC) recommended the conference be enlarged to incorporate Materials Research from Neutron, Muon, and Slow Positron Sources, as well as the science emerging from Synchrotron Light Sources. The conference brought together contributions from academics and industrial researchers with a diverse background and experience from the physics, chemistry and engineering communities. The topics covered in the LPBMS2013 include strongly correlated electron systems, magnetism and magnetic materials, soft matter, interface and surface defects, catalysts, biomaterials, and ceramics. In the 3-day scientific program, the conference consisted of 9 plenary talks, 33 invited talks, 20 oral presentations, and 126 poster presentations. We are pleased to publish the proceedings of the LPBMS2013 in this volume of Journal of Physics: Conference Series. This volume contains 58 papers representing the work that was presented and discussed at the conference. We hope that this volume will promote further development of this interdisciplinary materials research emerging from synchrotron light, neutron, muon, and slow positron sciences. Finally, we would like to thank the International Advisory Committee (Chair: Professor G N Greaves), sponsors, all the participants and contributors for making possible this international meeting of researchers. Reiji Kumai & Youichi Murakami Details of the program and organizing committees are available in the pdf


This book reviews South Sudan s modern history as a contested region and assesses the political, social and security dynamics that will shape its immediate future as Africa s newest independent state. This is an essential piece of reading for any scholars, policymakers and practitioners with an interest in the Horn of Africa, writes Ann Fitz-Gerald. The work is exceptionally well-researched and builds effectively and comprehensively on existing literature of scholars such as Douglas H. Johnston, Robert O. Collins and Martin Daly.


In this paper tectonics induced syndepositional tensile fracturing, faulting and block kinematics during structural evolution of this tertiary field has been reconstructed and the orientations of present-day horizontal stresses determined. Balanced cross-section using well coordinates and wireline logs correlation to portray the present-day architecture of the deformed geometry and stratigraphy has indicated two flank faults. The stratigraphic section depicts offlapping cyclic sedimentation in the middle to outer neritic environment during the Oligocene – Miocene epoch. Syndeposional shear displacement of the interconnected fractures in NE – SW and NW – SE fault trends indicate the directions of the maximum horizontal stress and present day maximum horizontal stress orientations determined from compressional shear failures in vertical wellbores depict NE – SW, NW – SE and ENE – WSW dominant directions consistent with the major fracture zones in the Gulf of Guinea along which triple-junction rifting into Nigeria's Benue trough aulacogen had occurred. Recent increase of earth tremors in Nigeria occurring in the NE – SW, NW – SE and ENE – WSW directions when correlated with the two tectonic episodes, the Aptian/Albian epeirogenic tectonism and the late Miocene – Pliocene faulting together with the presentday stress orientations all align in the axes of the major fracture zones that separated South America from Africa indicates that intraplate tectonic reactivation due to migration of the African plate along the major fracture zones that cut into Nigeria is imminent.


The spectral element method (SEM) has (with exact time integration) the desirable attribute of locally and globally conserving mass, energy and potential vorticity. It also scales well on massively parallel computers. Another desirable attribute of a numerical method for an atmospheric dynamical core is that it should have good numerical dispersion properties in order to accurately represent wave propagation and adjustment processes. Application of the SEM to the one‐way wave equation is analysed to provide insight into its dispersion properties as a function of spectral order. For the lowest‐order spectral truncation (linear) the SEM discretisation is formally equivalent to centred second‐order finite differences on an Arakawa A grid. It consequently shares its poor dispersion properties, including energy propagation in the wrong direction for the short‐wavelength half of the spectrum. Increasing the spectral truncation of the SEM to quadratic improves its dispersion properties for the long‐wavelength part of the spectrum, but the problem of energy propagation in the wrong direction for the short‐wavelength part remains. Further increasing the order of the spectral truncation not only fails to address the poor energy propagation at small scales, but also introduces new problems, including gaps in the spectrum of frequencies that can be represented, and localisation of eigenmode structures near element boundaries. Numerical integrations confirm that these SEM dispersion properties lead to reversed group velocities and to grid imprinting at spectral element boundaries. Copyright © 2012 Royal Meteorological Society and British Crown Copyright, the Met Office


—With the enhancement of data mining technology, competitive sports informatization has become an inevitable development trend. It has become a common phenomenon to use data mining technology to help athletes train scientifically, assist coaches in rational decision-making, and improve team competitiveness. In competitive sports, cyclists' adaptation to training has a complex relationship with their physical performance. In order to explore the correlation between data and provide better training data for athletes, this study proposes a load prediction model based on BP neural network (Back propagation, BP). Considering the local convergence and random assignment of traditional BP model, an adaptive genetic algorithm with improved selection operator is used to determine the initial weights and thresholds of BP neural network to improve the accuracy of the prediction model. The experimental results show that the improved adaptive genetic algorithm improves the overall optimization ability of the BP neural network, the improved BP neural network model has good stability in the convergence process, and the algorithm can search for better weight thresholds. Compared with the basic BP neural network prediction model, the accuracy of the optimized prediction model is increased by 11.86%, and the average error value is reduced by 26.21%, which is a guide to improve the training effect of the cycling team's competitive sports.


Provided is a device and a method for supporting a device from one platform. The means may comprise a clamp which is secured to the device on the platform; a mounting plate for receiving the device; and a clutch arrangement interconnecting the mounting plate with the clamp. The clutch assembly is operable to maintain a substantially equal predefined orientation of the mounting plate and the supported device, while the mounting plate is moving from a raised position of the mounting plate above the platform to a lowered position of the mounting plate below the platform.


Fluorinated amorphous carbon (a-C:F) films were deposited by radio frequency bias assisted microwave plasma electron cyclotron resonance chemical vapor deposition with tetrafluoromethane (CF4) and acetylene (C2H2) as precursors. The deposition process was performed at two flow ratios R=0.90 and R=0.97, where R=CF4/(CF4+C2H2). The samples were annealed at 300 °C for 30 min. in a N2 atmosphere. Both Fourier transform infrared and electron spectroscopy for chemical analyzer were used to characterize the a-C:F film chemical bond and fluorine concentration, respectively. A high resolution electron energy loss spectrometer was applied to detect the electronic structure. The higher CF4 flow ratio (R=0.97) produced more sp3 linear structure, and it made the a-C:F film smoother and softer. A lifetime of around 0.34 μs and an energy gap of ∼2.75 eV were observed in both the as-deposited and after annealing conditions. The short carriers lifetime in the a-C:F film made the photoluminescence peak blueshift. The annea...


Objective:To find out the effect of estrogen receptor (ER),vascular endothelial growth factor (VEGF),and matrix metal proteinase-2(MMP-2) on the pathogenesis of hemangioma and vascular malformation.Methods:Fresh operative specimens were collected and were divided into 2 groups:hemangioma and vascular malformation.The specimens of normal skin were also collected.ER,VEGF,MMP-2 were detected by immunohistochemical method.The correlations between the 3 markers were also analyzed.Results:High expressions of ER,VEGF,and MMP-2 were present in proliferating hemangioma.But in the involuting hemangioma,only ER had high expressions.ER,VEGF,and MMP-2 had very weak expressions in vascular malformation and the control.In the proliferating hemangioma,the expression of ER and VEGF had linear positive correlation.Conclusion:Estrogen,VEGF and MMP-2 have effects on the pathogenesis of hemangioma.They may have no effect on vascular malformation.