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Here is the weekly road construction report:
U.S. 41 (SR-8, Ringgold Rd.) grading, drainage and paving at the intersection of I 75 South off-ramp (LM 1.07) at Exit 1: The majority of work on this project has been completed. There will be no work during this report period. In the future, the contractor will be installing a traffic signal at the top of the ramp. Work will take place during non-peak daytime hours on Mondays through Saturdays. At least one lane on the ramp will remain open at all times. THP and flaggers will assist with traffic control as necessary. Estimated project completion date is March.
U.S. 27 (SR-29) reconstruction project from Manufacturers Road (Olgiati Bridge over the Tennessee River) to U.S. 127 (SR-8, Signal Mountain Road/Boulevard): Weather permitting, the contractor may have lane closures throughout the project area on weeknights to perform road work. They will also be working on retaining walls and bridges throughout the project area. During nighttime work, at least one lane will remain open in each direction. On Sunday beginning at 10 a.m. the contractor will be re-striping the roadway and ramps on U.S. 27 to brighten the worn pavement markings in the construction zone. The work is needed due to all the recent weather that has worn the markings significantly. The striping of the roadway will be a mobile operation and should be completed quickly. There will be lane closures for the entire project limits both northbound and southbound during the daylight hours to re-install missing raised pavement markers, which will be the most time-consuming portion of the work. The majority of the ramps will also require some re-striping, so motorists should anticipate some delays as the ramps are done. Traffic has now been shifted onto the new northbound Signal Mountain Road exit ramp. As a result, traffic accessing Signal Mountain Road and Dayton Boulevard from U.S. 27 North is now routed onto the new ramp that ends in a signalized intersection at Signal Mountain Road. The signal-controlled intersection as it is currently configured is only temporary while a new permanent two lane free-flow lane to Signal Mountain Road is constructed. The work to complete these new free flowing lanes is scheduled to be completed by the end of March. Meanwhile, we will continue to monitor the traffic and make adjustments to the signal timing along with whatever other temporary improvements we can make to move traffic as smoothly as possible during this phase of the project. THP will assist with traffic control on the project as necessary. Estimated project completion date is February 2015.
Shallowford Road widening project from Gunbarrel Road to Jenkins Road, including grading drainage, and paving: Work continues on this project. The contractor will be paving during this report period as weather and temperatures permit. Drivers are urged to be alert and to obey all traffic signs. Flaggers will be in place to assist with traffic control as necessary. Estimated project completion date is March.
Construction of a State Industrial Access route serving Volkswagen Group of America, including grading, drainage and paving: Work on this project continues. The contractor is in the process of clearing and taking care of environmental measures in order to start on road and drainage. Traffic will not be impacted at this time therefore, no lane closures are needed. Estimated project completion date is September.
August 29, 2016
An upcoming exhibition in the Museum Gallery of University Archives and Special Collections explores the creativity and workmanship of artists working in Mexico beginning in 800 B.C.E. and concluding ... (click for more)
ShapeShifter Gallery will present a show on Saturday, Sept. 10 during the "Gallery Hop" at Estate of Confusion, located at 301 E Main. The show and reception will last from 2-10 p.m. ... (click for more)
Beginning on Tuesday, at 8:30 a.m., McCutcheon Road, between Gunbarrel Road and Elam Lane, will be closed for construction. This closure is scheduled for five months, reopening ... (click for more)
An upcoming exhibition in the Museum Gallery of University Archives and Special Collections explores the creativity and workmanship of artists working in Mexico beginning in 800 B.C.E. and concluding in the 1990s. "Communal Spirit: 3,000 Years of Mexican Artistry" incorporates diverse Pre-Columbian artifacts from both western and eastern Mexico, representing eight different ... (click for more)
ShapeShifter Gallery will present a show on Saturday, Sept. 10 during the "Gallery Hop" at Estate of Confusion, located at 301 E Main. The show and reception will last from 2-10 p.m. "Vibrant colors, patterns, texture and a bit of organized chaos are themes explored in our second show. Three artists will be featured including Brian Giwojna, Mark Leamon, and ... (click for more)
More residential units are planned downtown near the riverfront on a steep lot at First and Cherry streets. The River City Company is currently seeking requests for proposals from developers for the steep 95-foot-by-65-foot lot behind the First and Market condos. River City officials said, "We are excited about how this parcel will put a finishing touch on this well established ... (click for more)
The Tennessee Bureau of Investigation has added to its 'Top 10 Most Wanted' list Jereme Dannuel Little, who was freed by order of Criminal Court Judge Rebecca Stern, whose decision was recently reversed. Little is wanted by the Chattanooga Police Department and the Tennessee Bureau of Investigation for especially aggravated kidnapping. The TBI said, "Little has a history of ... (click for more)
I was born and raised in Chattanooga and was brought up to be a Tennessee conservative. That means that my family conserved our spending, our resources, and yes, even our environment. I think we were inspired to do so because Tennessee is one of the most beautiful places in the entire United States. We have stunning mountains, wild rivers and quiet backcountry. And many of ... (click for more)
The United States Attorney's Office and our nation's Justice Department just thrust an unwelcomed spear into the heart of the state of Georgia. And while I am scared to death the same war party is now headed into Tennessee and other states, I wish the DOJ had stopped in Chattanooga for lunch and a quick visit at our Orange Grove Center before filing last Tuesday's lawsuit against ... (click for more)


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Oxidative stress and enhanced paracellular permeability in the small intestine of methotrexate-treated rats
- First Online:
- Received:
- Accepted:
DOI: 10.1007/s00280-009-1119-1
- Cite this article as:
- Maeda, T., Miyazono, Y., Ito, K. et al. Cancer Chemother Pharmacol (2010) 65: 1117. doi:10.1007/s00280-009-1119-1
We previously demonstrated the increase of reactive oxygen species (ROS) production and myeloperoxidase (MPO) activity in the small intestine of methotrexate (MTX)-treated rats. In the present study, we investigated the role of ROS modulating intestinal mucosal permeability in this damage.
MTX (20 mg/kg body weight) was administered to rats intravenously. N-Acetylcysteine (NAC; 80 mg/kg body wt), an antioxidant and a precursor of glutathione (GSH) was administered to rats intraperitoneally to investigate the contribution of ROS to the intestinal permeability enhancement. Intestinal permeability was evaluated by determining that of a poorly absorbable marker, fluorescein isothiocyanate-labeled dextran (FD-4; average molecular mass, 4.4 kDa) using the in vitro everted intestine technique. The occurrence of oxidative stress in the small intestine was assayed by measuring chemiluminescence and thiobarbituric acid reactive substances (TBARS) productions in mucosal homogenates of the small intestine.
The mucosal permeability of FD-4 significantly (p < 0.01) increased in MTX-treated rats compared with control rats, as demonstrated by a twofold increase of FD-4 permeation clearance. This suggests an increase in paracellular permeability. Interestingly, the ROS production was observed preceding the increase of paracellular permeability. Treatment with NAC prevented the MTX-induced ROS production and the increase of paracellular permeability.
NAC protected the small intestine of rats from MTX-induced change in paracellular permeability, suggesting that ROS played an important role in the enhanced paracellular permeability.
KeywordsMethotrexateReactive oxygen speciesIntestinal permeabilityChemiluminescenceN-AcetylcysteineGlutathione
Methotrexate (MTX) is an anti-tumor drug that is effective for the treatment of acute leukemia, trophoblastic disease, and intraosseous sarcoma, and has recently been used as an antirheumatic drug [1, 2]. MTX antagonizes folate metabolism and inhibits the de novo synthesis of thymidine and purine, constituent factors of nucleic acid, resulting in the inhibition of proliferation of rapidly dividing cells such as cancer cells [3]. Because intestinal epithelial cells also divide rapidly, their proliferation is easily inhibited by MTX. MTX often causes mucosal inflammation of the mouth and intestine, leading to nausea and diarrhea [4, 5]. The mechanism for this side effect has not been completely clarified. Symptomatic therapy, such as with antibiotics and antidiarrheal drugs, has been used to reduce the side effects [6–8].
There are many studies about MTX-induced intestinal damage, and some of them demonstrated that simultaneous treatment of some growth factors, the antioxidants, and the nutrients with MTX protected the small intestine from this side effect. For example, keratinocyte growth factor [9], insulin-like growth factor-1 [10], and melatonin [11] stimulate regrowth of the damaged intestine and protect mice and rats from gastrointestinal injury. We also demonstrated a protective effect of retinol [12], docosahexaenoic acid [13], aged garlic extract [14], synthetic analogs of prostaglandin [15], and sodium tungstate [16] on MTX-induced intestinal damage.
MTX-induced intestinal damage is accompanied by a decrease in the function of intestinal barrier due to cell proliferation inhibition, and following invasion of xenobiotics and endotoxins. Accordingly, phagocytes, such as macrophages and neutrophils, infiltrate into the inflammatory region, and produce reactive oxygen species (ROS) [16, 17]. This is the well-known biophylaxis reaction. Chemotherapy-induced intestinal mucositis is now characterized by a five-phase model: (1) initiation, (2) upregulation and message generation, (3) signaling and amplification, (4) ulceration, and (5) healing [18]. In this model, ROS generation during the chemotherapy is the first step leading to intestinal inflammation. Moreover, the potential role of ROS in activation of nuclear factor-кB, an inflammatory-related transcription factor that upregulates inflammatory cytokines and adhesion molecules, is also suggested to be involved in intestinal inflammation.
The diseases such as inflammatory disease, cancer, ischemia–reperfusion injury, and diabetes, and the side effects of drugs like doxorubicin and cisplatin are related to oxidative stress [19, 20]. The protective effect of antioxidants for these side effects of anticancer drugs had been reported [21, 22]. On the other hand, ROS at very low concentration modulate the cell function and act as signal transmitter on apoptosis, cell proliferation, cell adhesion, and chemotaxis through regulation of nuclear transcription factors [23].
We reported an increase of intestinal paracellular permeability [24], ROS production [16, 25], neutrophil migration [16], and a decrease of intracellular glutathione (GSH) [16, 25] after MTX treatment in rats. Simultaneous use of prostaglandin E1 analogs [15], retinol [12] and aged garlic extract [14] prevented such a change in the intestinal paracellular permeability. N-Acetylcysteine (NAC), an antioxidant and a precursor of GSH, prevented such decreases of intracellular GSH and neutrophil migration [16].
ROS are reported to regulate the paracellular permeability and tight junction opening [26, 27]. The barrier function of tight junctions is maintained during neutrophil transepithelial migration, but high-density neutrophil migration can damage the integrity of epithelial cells [28, 29]. In this study, we intended to verify the hypothesis that the oxidative stress caused by the MTX treatment enhances intestinal paracellular permeability.
Materials and methods
MTX was kindly supplied from Wyeth Lederle Ltd. (Tokyo, Japan). NAC was purchased from Wako Pure Chemical Industry Ltd. (Osaka, Japan). FITC-dextran (average molecular weight, 4,400 Da; FD-4) was obtained from Sigma Chemical Company (St Louis, MO, USA). All other reagents were of analytical grade.
Male Wistar rats (7 weeks of age; Japan SLC Inc., Shizuoka, Japan) were housed under 12 h light/dark cycle at an ambient temperature of 25°C and given food (MF diet, standard laboratory diet commercially available, Oriental Yeast Company, Ltd., Tokyo, Japan) and water ad libitum. They were acclimatized for 1 week before starting experiments.
Drug treatments
A single dose of MTX (20 mg/kg body weight) was injected intravenously into the rats. Control rats received the equivalent volumes of saline solution intravenously. NAC (80 mg/kg body wt) was injected to rats intraperitoneally at the same time with MTX administration. The treatment of rats was carried out as the following groups: saline solution (control), MTX alone, MTX and NAC, and NAC alone. Each group has 4 rats. All experiments were approved by the animal care committee of Chiba University.
FD-4 permeation in small intestine
Intestinal permeation was examined in vitro using everted segments of the small intestine, as described previously [24]. Rats were anesthetized with diethylether and their intestines were removed. Intestinal segments (14 cm) were cut out at a distance of 3 cm from the end of the duodenum. The segments were everted in ice-cold saline solution. A glass cannula was inserted into each end of the everted segment and a 10 cm plastic syringe was attached to the exposed end of each cannula as described by Doluisio et al. [30]. The segments were then placed in 40 mL of incubation medium (modified Krebs–Ringer bicarbonate–phosphate (mKRBP) buffer, pH 7.4) containing FD-4 at 37°C. Five milliliters of the buffer was added to the serosal side of the segments via the syringe. The plungers were gently moved up and down. Gas (95% O2–5% CO2) was gently bubbled into the buffer on the mucosal side during the absorption experiments. At designated times after the start of the experiments, 300 μL of sample solution was taken from the serosal side to determine the permeation of FD-4 and, at the same time, a similar volume of buffer was added to maintain the volume of the serosal side constant. Then, 30 μL of sample solution was taken from the mucosal side to determine the concentration of FD-4 in the mucosal side. The sample solutions taken from the serosal and mucosal sides were diluted with mKRBP buffer. The fluorescence intensity of FD-4 in the sample solutions was determined at an excitation wavelength of 495 nm and an emission wavelength of 515 nm using a Hitachi fluorescence spectrometer F-2000.
Data analysis
Preparation of small intestine homogenate
The rats were killed by decapitation at 24, 48, and 72 h after the treatment. The small intestine (about 40 cm in length from the end of the duodenum) was removed and washed with ice-cold saline solution. Immediately after the scraped mucosa from the intestine (about 30 cm length) was homogenized, chemiluminescence and TBARS in the homogenates were measured to evaluate the oxidative stress. The homogenates were used for the assays.
Chemiluminescence analysis
ROS production in the small intestine was evaluated by in vitro luminol-enhanced chemiluminescence as described previously [25]. In vitro experiments: intestinal mucosal scrapings (0.1 mg) were homogenized with 1 mL of ice-cold oxygenated carbonate buffer (50 mM, pH 9.0). The suspension was centrifuged at 15,000 rpm for 2 min by Beckmann Microfuge E™ and the supernatant was used for the assay. The samples were mixed with an incubation mixture containing 5 mM glucose and 400 μM luminol in phosphate buffered saline solution (PBS). The luminol-enhanced chemiluminescence from the samples was measured at 37°C using a single photoelectron counting system (Tohoku electronic Industries Co., Ltd., Sendai, Japan). The chemiluminescence was expressed as counts/min/mg protein by subtracting chemiluminescence of the incubation mixture only.
TBARS assay
Thiobarbituric acid reactive substances (TBARS) in intestinal mucosa were assayed by the method of Buege and Aust [31], and were expressed as nmol of malondialdehyde (MDA) equivalents per milligram protein. Briefly, the intestinal mucosa (0.1 mg) was homogenized with 1 mL of 15% trichloroacetic acid (TCA). Thiobarbituric acid (TBA) reagent (15% TCA, 0.375% TBA and 0.25 N HCl) (2 mL) was added to the mixture, followed by boiling for 15 min. The reaction mixture was then cooled and was centrifuged at 1,000g for 15 min. The absorbance of supernatant at 535 nm was determined with 1,1,3,3-tetraethoxypropane as the standard.
Statistical analysis
Statistical analysis was undertaken using two-way analysis of variance (ANOVA) followed by Turkey–Kramer's post hoc test. A level of p < 0.05 was considered to be statistically significant.
FD-4 permeation
NAC treatment
Oxidative stress
Body weight change
Oral administration of MTX to rats and mice caused small intestinal damage and enhanced the permeation through the paracellular pathway of the small intestine [15, 24]. Since MTX is administered not only orally but also intravenously in clinical use, it is important to know how the different administration routes of MTX affect the small intestine. The effect of intravenous injection of MTX on the small intestine was examined using the permeation of the non-permeable macromolecule, FD-4, in the small intestine. FD-4 permeation of the small intestine increased at 48 h after a single intravenous injection of MTX to rats. The intravenous injection of MTX was also shown to affect the paracellular pathway of the small intestine, as was the oral administration. The permeation of FD-4 in the small intestine was not affected at 24 and 72 h after the intravenous injection of MTX to rats, which may be related to the turnover rate of small intestinal epithelial cells.
We reported that MTX administration in rats enhanced the production of ROS in small intestinal mucosa [16, 25]. MTX-induced enteritis was reported to be ameliorated by melatonin, having an antioxidant effect [11]. ROS is reported to activate tyrosinekinase and phosphatidylinositol3-kinase, and alter the localization of components of tight junctions [26, 27], resulting in change of the paracellular permeation. Thus, it is important to clarify whether ROS is related to the alteration of small intestinal permeation of MTX-treated rats.
MTX administration to rats decreased the intracellular GSH of intestinal epithelial cells [16]. The coadministration of NAC, the precursor of GSH, with MTX in rats preserved the FD-4 permeation of the small intestine to the level of that in rats treated with saline alone (control). This is possibly due to improvement of the intracellular redox state accompanied by the increased GSH and/or the antioxidative effect of NAC itself. Thus, ROS were shown to contribute to the increased permeation of the small intestine caused by MTX.
The occurrence of oxidative stress in the intestinal mucosa of rats treated with MTX was examined, using an ultraweak chemiluminescence instrument. The chemiluminescence was used for detection of ROS production in the intestine. Luminol-enhanced chemiluminescence was detected in the homogenate of intestinal mucosa of the MTX-treated rats. The chemiluminescence from the homogenates reached a maximum intensity at 24 h after MTX administration to rats and its intensity was still high even at 48 h. The coadministration of NAC with MTX to rats depressed the ROS production to the control level at 24 and 48 h after MTX treatment. Following ROS production, lipid peroxidation occurred, as shown by the production of TBARS. TBARS produced in the intestinal mucosa significantly increased at 48 h after MTX treatment in rats. The TBARS production was depressed by the coadministration of NAC with MTX to rats. We previously reported that the activity of myeloperoxidase, which is a marker enzyme of glanulocytes and reflects the neutrophil infiltration in intestinal mucosa, increased at 48 h after the MTX administration to rats, but not at 24 h [16]. Thus, the enhanced ROS production at 24 h shown in this study seems not to originate from inflammatory cells like neutrophils at the inflammation site.
As shown here, the paracellular permeation of the small intestine was altered followed by the ROS production. Under oxidative stress conditions, it is reported that the epithelial paracellular permeability is altered by the change in localization of occludin and ZO-1, which compose tight junctions [27]. Therefore, the change of protein localization in tight junctions is reported to be mediated by tyrosine phosphorylation [27, 32]. Such molecular mechanisms in tight junctions are under investigation to further elucidate the mechanism of enhanced permeation of paracellular pathway in the small intestine of MTX-treated rats.
MTX treatment decreased the body weight of rats at 24 and 48 h. However, since the coadministration of NAC with MTX did not prevent their loss, such loss of body weight may possibly be caused by the action of MTX itself rather than by the generated ROS. On the other hand, the MTX treatment of rats increased the FD-4 permeation of the small intestine at 48 h and the treatment of NAC with MTX prevented this enhancement of intestinal permeability, suggesting that the enhanced permeability of the small intestine is due to ROS.
Aged garlic extract has been shown to prevent the damage of the small intestinal epithelial cells caused by MTX [33, 34]. To perform effective MTX therapy for cancer treatment, it is important to develop a method of treatment to prevent MTX-induced small intestinal damage, including finding protective substances like aged garlic extract.
In conclusion, the present study has clearly shown that the MTX-induced ROS plays an important role in the enhancement of paracellular permeability of small intestine in the MTX-induced intestinal damage of rats.

subset: commoncrawl


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Tags » The Temptations
A Date in Mystic
PBS once did a History Detective special on Cemeteries. Our personal history dates back 51 years and we are forever exploring final resting places when traveling. 559 more words
Classic Music Review: In the Court of the Crimson King by King Crimson
Revised and updated, July 2016.
With great dismay, I learned that at least one critic described In the Court of the Crimson King as "the most influential progressive rock recording in history." 1,450 more words
Forever Motown At The Downtown Cabaret Theatre
It has been ages since we have frequented the Downtown Cabaret Theatre in Bridgeport, CT. We've always liked the ambiance of this venue. You can BYOB with an intimate setting that seats just 209 people. 240 more words
The Temptations Sing "Just My Imagination (Running Away With Me)"
Listen to this track by five man Motown pop soul institution The Temptations. It's "Just My Imagination (Running Away With Me)", a smash hit single as taken from the group's 1971 record… 826 more words
Friday Favorites
Happy Friday! Oh, how I love this day. Let's get right into my Friday Favorites!
F Scott. Fitzgerald
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Rim Hospitality Appoints VP/Special Projects and VP/F&B
Thursday May 9th, 2013 - 9:39AM
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NEWPORT BEACH, CA—Rim Hospitality has made two key appointments: Tony Bruno as VP/special projects and Al Ferrone as VP/food and beverage.
Bruno has nearly 25 years of experience in the hospitality industry. Currently, he is serving as general manager for the Sheraton Park Hotel at the Anaheim Resort, a Rim Hospitality portfolio property. Prior to that, he spent 25 years with the Disneyland Resort properties in California, most recently serving for nine years as VP/hotels & Downtown Disney. He was responsible for leading and executing strategic operations for numerous properties and initiatives, special events and VIP services. Bruno also worked with the Worthington Hotel in Fort Worth, TX, and Marriott's Rancho Las Palmas Resort in Rancho Mirage, CA.
Ferrone is responsible for developing restaurant concepts; overseeing training, menu planning and purchasing programs; creating special promotions; executing strategic marketing concepts; and managing the overall F&B operations for multiple Rim Hospitality properties.
He most recently served as corporate VP/hospitality, ESS division for Caesars Entertainment Corp., where he was responsible for overall non-gaming areas of operations for 40 properties. He played a significant role in the hotel and food and beverage strategies for Caesars Palace, Harrah's, Horseshoe Hotel & Casino, Bally's, Paris Hollywood, Rio, Showboat, Grand Biloxi and The Flamingo hotels in Las Vegas. Additionally, Ferrone was responsible for programming and designing new projects including, Horseshoe Cleveland, Horseshoe Cincinnati, Caesar's Palace Boston, Harrah's Baltimore, and the renovation of Bill's Las Vegas.
Prior to working with Caesars Entertainment Corp., Ferrone was the principal of AFHS Food and Beverage Business Solutions, LLC, where he provided consulting services to hotel, restaurant and related industries. Ferrone previously spent 20 years with Hilton Hotels Corp. in F&B senior management positions. He also held a number of senior-level F&B positions at hotels including, The Waldorf-Astoria New York, Le Parker Meridien and New York Marriott Marquis.
Tags: • Hospitality • Owners/Operators •
Technology has transformed travel. It's that simple. From virtual-reality tours to mobile check-in to storing and personalizing guests' preferences, technology is continuing to influence the way we stay and vacay, so to speak. And it's also continuing to impact the way hotels do business. It comes down to this equation: guests' demands + hotel delivery = happy customers.
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Solid Rock Group Leads Acquisition of Two Hotels
B. Debuts at Hilton Chicago/Oak Brook Hills
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August 28, 2016 from 1pm to 6pm – Harugari German American Club Its an August tradition is West Haven! The annual Harugari Pig Roast. Come on down to the club for some German Bier, German Food and slow roasted pork. The Adlers will be performing for your listeni… Organized by Harugari German American Club | Type: beer, fest, &, pig, roast
September 6, 2014 from 12pm to 5pm – Library Park Join us at the 8th Annual Brass City Brew Fest and sample a variety of craft beers, including Thomas Hooker beer! Organized by | Type: brew, fest
September 20, 2014 from 4pm to 8pm – Ski Sundown, 126 Ratlum Road, New Hartford, CT 06057 First 20 people to purchase a Ski Sundown fall brewfest ticket get a free CT Beer Trail Trail Blazer's Club card! Trail Blazers save $5 on their ticket if they purchase it the day of the event at th… Organized by Ski Sundown | Type: brewers, fest
October 4, 2014 from 12pm to 4:30pm – Seymour Community Center SAVE $10! Trailblazers-show your card at gate and pay $35. Ticket winners! Our First Winner is: Brianna Leigh! Our Second Winner is: Beth Braccia Brucker! Our Third Winner is: Elizabeth Wolter! Our… Organized by Matt Bronson | Type: beer, fest
October 6, 2014 from 6pm to 9pm – Two Roads Brewing Company Over 20 CT brewers under one roof at the first ever Connecticut Brewers Fest presented by Two Roads Brewing. $25 gets you a can glass and three oz pours of some of the best beer the Nutmeg state has… Organized by Two Roads Brewing Company | Type: beer, fest
May 2, 2015 from 12:30pm to 3:30pm – Quassy Amusement Park On May 2nd, 2015 from 12:30pm to 3:30pm come sample dozens of beers and spend the day at Quassy Amusement park! Breweries include: Harpoon, DuVig, City steam, Black Hog, Shiner, Two Roads, Captain La… Organized by Quassy Amusement Park | Type: charity, beer, fest
June 13, 2015 from 12pm to 4pm – Harugari German American Club Craft Brew Festival hosted by The Harugari German-American Club. Come down and sample beers from your favorite breweries while DJ Jim plays for your enjoyment. Tickets $30 in advance, $40 day of ev… Organized by Harugari German American Club | Type: fundraiser, craft, brew, fest
December 12, 2015 from 12pm to 4pm – Overshores Brewery Overshores BelgXmas Bash - Sat. Dec. 12th, 12-4pm, Food trucks, live music, brewery exclusive beers, games, prizes Free Admission. 250 Bradley St, East Haven, CT Brandt Taylor Band will be playing an… Organized by Overshores Brewing Co. | Type: holiday, beer, fest
March 3, 2016 from 7pm to 10pm – City Steam Brewery Please join us in wishing farewell to our legendary Brewmaster, Ron Page, at our 5th annual March Madness Brew Fest right here at City Steam Brewery, 942 Main St. Downtown Hartford! Your $35 ticket i… Organized by City Steam Brewery | Type: brew, fest
May 28, 2016 from 1pm to 5pm – Oscar's Bistro and Bar COME CELEBRATE SUMMER at this 1st Annual Outdoor BBQ & Beer Fest exclusively featuring Two Roads Brews on the outdoor taps!!Live music! Food specials! An all around summer smash in Milford! Organized by Jared Emerling | Type: tap, takeover, and, beer, fest
July 31, 2016 from 1pm to 6pm – Harugari German American Club Time to tap a keg, raise a mug and dance a polka! Its Bierfest time under the pavilion. Come on down to the club for some German Bier, German Food and some great German music by The Austrian Boys. … Organized by Harugari German American Club | Type: beer, fest
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Brady Chauvin
- BiographyDuring the course of his 21 year long pornstar career, this white male porn veteran filmed in 1 video scene, debuting in Mens Lounge 8: Gays To The Knees in '95. Brady Chauvin's preferred activities are Anal Sex, Blowjobs, Hardcore, Sex Toys, and Handjobs. He was added to favorites once by Gay Access members. On average, 100 percent of our members have given this star a thumbs up rating. Content starring this model has been viewed 63,590 times in total, with well over 0.8 GB of exciting porno having been transferred. Other actors who have co-starred with Brady are Sonny Silver.
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Live mixes from "Dj Holla D" a 16 year old from Elizabethtown, Kentucky, who has recently gotten into the mixing scene from influences like Dj Bl3nd. He is featured on Youtube (Mitv3) as well as Facebook ( Dj Holla D).


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Parents warned to be on the lookout for signs of whooping cough
Parents have been warned to be on the lookout for symptoms on whooping cough.
Source: ABC News | Duration:
As the internet and real-world facilities intersect, hackers are infiltrating critical infrastructure.
By Emily Porrello and Belinda Hawkins
Footballer Moana Hope and Western Bulldogs vice-president Susan Alberti spearheaded the movement for a national women's AFL competition.
Analysis by political reporter Matthew Doran
This week Parliament returns after a 116 day hiatus, and Prime Minister Malcolm Turnbull's clasp on power is weakened.
The state that should be the richest is in desperate straits, global resources companies are notching up losses by the score and the car industry is being killed.


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Crop devastation
Local farmers struggle with ducks and water hens.December 25, 2012 4:50am
Ducks are wreaking havoc for local farmers, who are struggling to survive the irreversible damage they cause to rice crops.
Ducks forced Colin McCrabb to re-sow the entire rice crop at his Wanganella property.
Native black-tailed water hens are an issue in the Wakool area, which Department of Primary Industries agronomist John Fowler said were far more destructive.
Mr McCrabb said it was the most persistent he has seen the ducks in at least 15 years, and said they had cost him thousands of dollars.
Mr McCrabb had sown 46.5 hectares of rice on his 'Shelbourne' property in October, and a month later was forced to re-start his rice crop.
''We sowed at the end of October and things were very quiet until about mid-November,'' he said.
''After we got about two days of rain the ducks started coming in.
''I have never seen them so persistent. You lift them off, can spend an entire hour chasing them off, and an hour later they're all back again.
''On one occasion two bays were black, just chock-a-block full of ducks.''
Mr McCrabb has found the ducks are arriving during the night and staying on the rice bays most of the day.
During November, Mr McCrabb said he noticed a large number of rice shoots and seeds washed up on the side of the bays.
He left the bays to drain a little before walking out through the mud to investigate the full extent of the duck damage.
He was devastated to find that not many seeds and shoots had been left in the ground.
And the damage occurred despite the McCrabbs using duck deterrents.
''They had taken all of the seed out, even though we had duck lights and shooters.
''I now have a duck light with a siren and scare guns, and we're still having shooters come out on weekends.
''I'm just lucky my son Angus is home to help keep the ducks moving, otherwise I'm not sure where I would be because I'm trying to sort out sheep for joining at the same time.''
Mr McCrabb said the cost of the duck damage was well in excess of $10,000. He has been forced to buy two lots of seed, priced at $2500 each time, and two doses of chemical. He has also had to hire a plane in the sowing process twice, which he also estimated cost about $2500 each time.
Mr McCrabb said the ducks were still posing a significant threat to his rice crop, and he is not confident the rice will survive the influx.
He believes the increase in duck numbers this year is because of the healthy wetland environments in the Wanganella area.
He said with the nearby swamps full of water for more than 12 months, duck breeding had boomed.
Excess water in the system for a long period of time is also blamed for the insurgence of black native ducks in the Wakool area, according to farmer Greg Lodge.
''We've got water hens in their thousands — they're almost at plague proportions,'' he said.
''I've gotten through my concerns, but they had been eating the grain originally, and then as the rice was growing eating off the top.
''I had to camp out for a while.''
Mr Fowler said the native hens were being termed 'turbo chooks' because of how quickly they can cause widespread damage.
''The huge problem is the black tail water hens,'' he said.
''In the Wakool area some people are wondering if they may still have a future in rice as long as they are around.
''Normal water ducks eat the grain, but these black hens eat the foliage and leave nothing behind them.
''There have also been some complaints about the hens in the Bunnaloo and Caldwell areas.
''These hens are the new kids on the block, and they are hitting hard with a vengeance.''
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Wilson's taking it all in his stride
Grant Wilson is feeling right at home in his new role of league operations manager at AFL Goulburn Murray.
Bears get first finals win
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Respected Aboriginal elder dies
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You can't dim this shining star
CLAIRE Murphy came home the other day.
Be WICKED, just like Barry
BE LIKE Barry — the video by Campaspe Shire to educate children about recycling — was launched at St Mary's Primary School on Monday.
Wyuna Hall packed for military book launch
WYUNA's Memorial Hall was filled with over 80 people for the recent launch of the Wyuna History Group's third book by Wyuna History Group researcher Noel Thompson – Wyuna Honour Roll 1914-1918.
Thrills and spills at derby
Avenel win over Nagambie to take top spot
Hall offence
Berrigan Shire councillor Daryll Morris says he has been sickened by some of the vitriol and personal attacks to surface since the council's proposal to redevelop Finley's Memorial Hall and School of Arts site was revealed in October last year.
Change sees winery take flight
WINE is meant to be enjoyed with good food and good friends.
Lined up for swap meet.
The preparations for the 10th Cobram Swap Meet have been given a boost with a brand new line marker. The Rotary Club of Cobram, which organise the swap meet, applied for a volunteer grant from the Federal Government, from which it received $4600.
Deni's dance queens
Deni's Debutante Ball gurus Vicki Ackers and Deb O'Connor love working with youth.
Shepparton cattle sale
Tuesday, August 16
Dookie stars in award winning short film
Comedian Peter Rowsthorn and Khye Skoda star in Welcome To Dookie.
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Canary Wharf Screen: Suki Chan
The soporific effects of time-lapse photography are employed to their fullest extent in this excerpt from Suki Chan's film Sleep Walk Sleep Talk. London slips by in indigo hues, light rushes past on the backs of trains and radiates from high-rise windows. Drawing upon the artist's interest in urban spaces, the film interweaves static camera shots with personal portraits, "highlighting revealing responses to the mania of London life." Like the scientist who finds beauty in the controlled chaos of an anthill, Chan's film admires the symmetry of a city when viewed from afar. Hypnotic stuff.
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- Things: the inspiring post that got us through the long hot summer nights of August


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Job Locations US-NY-New York Category Campaign Management & Consulting Travel 10% Level .. More information about this job: Overview: Engagement Associates are thoughtful, high-impact contributors with exceptional analytical, communication, program management, and client7/25/2016 New York, NY Save This Job
Location: Apple Valley, MNDepartment: IT Enterprise ServicesType: Full TimeMin. Experience: Mid Level Associate Systems Administrator Note: you must already be located in the Twin Cities, MN. SUMMARY: Join us as Associate Systems Administrator and you will have a8/8/2016 Apple Valley, MN Save This Job
About Courion Are you someone who thrives in a fast paced, team environment? Do you like being on the leading edge of technology? If so then come join our innovative, driven, and remarkable team of cyber-security experts! Courion is the market leader in identity and access7/24/2016 Roswell, GA Save This Job
Job ID 2016-1881 Job Locations US-CA-Chatsworth Job Posted Date 7/19/2016 More information about this job Overview DataDirect Networks (DDN.com) is a world leader in massively scalable storage. We are the leading provider of data storage and processing solutions and7/23/2016 Chatsworth, CA Save This Job
Location : Florham Park NJ US 07932 Job Type : Full Time Shift/Hours : First Shift (Day) Career Level : Experienced (Non-Manager) Education : Bachelor's Degree Category : AV Technology Job Description : For over 25 years, Yorktel has been the video managed services partner around7/23/2016 Florham Park, NJ Save This Job
Job Description Vice President, Western Sales - (16041) What you'll do: What to Expect brand is the world?s best-known and beloved pregnancy brand. With the leading pregnancy mobile app suite, a robust web site, newsletters and strong social presence, this iconic brand is now7/6/2016 New York, NY Save This Job
All times are in India Standard Time. ID 2016-2448 Job Location US-PA-Plymouth Meeting US-AZ-Scottsdale US-WA-Seattle US Posted Date 6/20/2016 More information about this job: Overview: Accolade Mission Summary Accolade is an on-demand healthcare concierge for employers,6/28/2016 Plymouth Meeting, PA Save This Job


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Serenidad Consulting® recognized as a "A world-changer"
Serenidad Consulting® was created in January 2010, founded on the unwavering principles of Excellence, Great Leadership and Positive Personal Power. These principles are reflected, as much as humanly possible, in every aspect of our business operations and philanthropic activities world-wide.
As an internationally-recognized business leader, peace advocate and effective change agent, its founder and Chief Executive Officer, Nola Hennessy, leads this truly unique and evergreen organization in its strategic intent to facilitate peaceful relationships. Nola looks at global peace through an educator's lens, is committed to working alongside like-minded others to see this vision become a reality, and has an enduring commitment to empowering others.
Serenidad Consulting® remains focused on the strategy of prevention to achieve sustainable change, and Nola is ably supported by its dedicated consultants and Nicholas Mostyn, Strategic Advisor-Global, who has been an important contributor to our growth since 2011.
Why are we unique?
Serenidad Consulting® was formed to empower, inform, guide, and support. Each consultant and employee who joins and stays within our broader team, regardless of their regional location, demonstrates a commitment to our vision, Quality Policy and principles. Serenidad Consulting® is led with passion and purpose, the intent of achieving peace, and a focus on paying-it-forward in every possible context. To that end, creating The Peace Ranch® as our key global location was an obvious next step in our growth.
Our Quality Policy articulates an unwavering commitment to standards that others aren't willing or able to achieve. And, interdependently, Nola's internationally acclaimed, multi award-winning literary works and signature education products provide the foundation stones for all that we do.
Media Information:
Our strategic intent and background information is further explained on the Welcome Page.
2. Media Engagements & Appearances
Dec 7th 2016: Voice America Empowerment Channel, invited interview
Recent Media Coverage:
|June 2016: The Australian Peacekeeper Magazine, Winter/June 2016 issue, features our latest article "Prevention Focused Education and Sustainable Peace"
|May 2016: Serenidad Consulting® recognized as a "A world-changer", The COVE Magazine
|March 21, 2016: Australian Peacekeeper Magazine has featured our article on Conflict Resolution and Peace starting with Individual Commitment
|December 16, 2015: Invited Guest Nola Hennessy speaks openly on Voice America's Empowerment Channel, about achieving relationship and global peace through inner peace, education, communication and living integrity. Read more on VA Press Pass.
|December 1, 2015: Australian Peacekeeper Magazine has featured our article on achieving a shift to global peace whilst still supporting the military
|Wednesday November 25, 2015: Invited Guest, Nola Hennessy emphasizes the importance of healthy, positive relationships and global peace being founded on inner peace. She speaks with host Cynthia Brian on Voice America's Empowerment Channel
|September 1, 2015: Australian Peacekeeper Magazine has featured our USA Trademark in the latest Spring (Sept) 2015 Edition
|Wednesday August 5, 2015: Invited Guest, Nola Hennessy's passion, purpose and desire to see the world become a better place shine through in this informative interview about Global Peace and eliminating terrorism and violence, with host Cynthia Brian on Voice America's Empowerment Channel
|June 1, 2015: Our latest editorial on eliminating terrorism "What if we think prevention, instead of reaction?" is featured in the Winter (June) 2015 Edition of Australian Peacekeeper Magazine
|May 6, 2015 - Nola Hennessy discusses integrity, truth and accountability during her Life Angelz, LA Talk Radio interview with Traci Lynn
Monday February 9, 2015: Nola Hennessy thoroughly enjoyed her broad, deep and meaningful conversation with Cyrus Webb about humanity, her books and companies' work: Her full interview is available on CONVERSATIONS Live
|Wednesday December 10, 2014: Broadway World covers the recent "Best Autobiography" award for The Peace Angel memoir, on its books site
|Wednesday December 10, 2014: Voice America, with a message of Peace for the holiday season
|November 26, 2014: A Special Thanksgiving Message of Positivity on Voice America
|October 31, 2014: Voice America Empowerment Channel's 'Empowering Women, Transforming Lives' show releases their interview with Nola Hennessy about personal power and choices
|October 21, 2014: Huff Post Women shares our contribution to "5 Questions to Ask Before Choosing a Mentor"
|October 20, 2014: Read our contribution to Business News Daily's article on "Women Seeking Mentors: 5 Questions to Ask"
|October 1, 2014: Interview with Cynthia Brian on Voice America Empowerment Channel - a focus on peace, harmony and positive relationships
|September 16, 2014: Interview with Kim Stewart on Voice America 'Business Channel': Stepping Stones to Everyday Success
|August 24, 2014: Interview with Priscilla Leona on LA Talk Radio, Question Reality Show
|August 2014: A comprehensive interview about PTSD on Out of the Box Podcast, West Hollywood – a gripping and informative interview
|Wednesday August 13, 2014: Broadway World covers the release of The Peace Angel memoir on its new books site
|Wednesday June 11, 2014: On Voice America's Empowerment Channel, Nola Hennessy is interviewed about her upcoming autobiography, why women need to become resilient rather than "toughen up", and provides an update on planning and action for the company's new head office in the Dallas/Forth Worth greater metroplex. Full interview.
|March/April 2014: Nola Hennessy is featured in the Author Spotlight section of Focus On Women Magazine's latest edition and there is a further spotlight on Nola's multi award-winning book on Great Leadership, No Boxing Allowed.
|Wednesday February 12, 2014: Listen on Voice America's Empowerment Channel about a woman of passion, love, and positive power. Full interview.
|Wednesday November 20, 2013: Nola Hennessy was interviewed by Cynthia Brian on the eve of the anniversary of President Kennedy's assassination. Nola discusses her thoughts on power and control imbalances as causal factors for conflict and misunderstanding – Full interview.
|Monday August 19, 2013: KRMagazine in the UK provides specialist insight into current trends in kidnapping for ransom………..they have kindly promoted our upcoming seminars on Post Traumatic Stress and Building Community Resilience, being held in November in Sydney and Melbourne.
|Wednesday July 3, 2013: Voice America's Empowerment Channel. Full Interview. Read the early review by Cynthia Brian.
|June 2013: Patricia Kime shares her interview with Nola Hennessy, in the US Army Times , Air Force Times, Navy Times and Marine Corps Times
|Thursday March 21, 2013: Forgiveness is the key to happiness and harmony and Nola shares how we can bring more of both into our lives. Full Interview.
|Friday March 8, 2013: Healing From PTSD and Moving Forward With Life
|Monday January 14, 2013: Bonnie Graham interviews Nola on READ MY LIPS Talk Radio. Full interview.
|Thursday January 10, 2013: Nola Hennessy ignites the New Year. Full interview.
3. CEO Speaking Engagements
4. Downloadable Articles
Achieving Global Peace - CONFLICT RESOLUTION AND PEACE STARTS WITH INDIVIDUAL COMMITMENT
Shifting Attitudes & Behaviors - ACHIEVING A 180o SHIFT TO GLOBAL PEACE AT THE SAME TIME AS SUPPORTING THE MILITARY
Preventative Measures and Education - WHAT IF WE THINK PREVENTION, INSTEAD OF REACTION?
Reinventing Yourself – THE OPPORTUNITIES AND CHALLENGES FACING PEOPLE OVER 40
Post-Traumatic Stress – HEALING FROM PTS AND MOVING FORWARD WITH LIFE
Family/Parenting – FAMILY BUSINESS – BEING ACCOUNTABLE FOR YOUR ACTIONS AND WORDS
Health/Wellness – BEING AND STAYING HEALTHY AND HAPPY
Work Health and Safety – GREAT LEADERSHIP IN SAFETY
Family Law - a New Organizational Approach to Client Service - ADMINISTRATION IN THE FAMILY COURT OF AUSTRALIA – LOOKING AHEAD, Len Glare OAM


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Ghost Whisperer 2005 | TV Show Watchlist
Season 4, Episode 2 Big Chills
First Aired: October 10, 2008
Melinda uncovers dark secrets among a circle of her high-school classmates after one of them dies unexpectedly. Grace Adams: Rachael Leigh Cook. Ryan Keller: Jason London. Haylie Wayne: Anna Silk.
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Choose the period
Today, during a conversation, my boss said, "What, what?" Before I could stop myself, I replied, "In the butt." FML
by whitecollar / 12/04/2012 at 9:43pm / United Kingdom (York) / Work
Today, I made a positive remark to the owner of my local groceries store for employing a special needs girl. Not only is the girl not mentally handicapped, she's also the owner's daughter. FML
by Vassy / 12/04/2012 at 1:51pm / Canada (Quebec) / Miscellaneous
Today, while at work taking notes on a pad of paper, my boss witnessed me trying to scroll down on the paper, as if it was a touch-screen phone. FML
by mdg / 12/04/2012 at 12:16pm / United States (Connecticut) / Work
Today, my boss was telling everyone that he knew a guy who went to a college at which multiple people were shot and killed recently. Being extremely socially awkward and uncomfortable, I blurted, "That's awesome." Now everyone in the office is terrified of me. FML
by Adan / 12/04/2012 at 4:34pm / United States (Washington) / Work
Today, my boyfriend and I had a disagreement over the pronunciation of the word "train." It turned into a heated debate that lasted all night and ended with us sleeping in separate rooms. FML
by superminty / 12/04/2012 at 3:12am / Canada (Ontario) / Love
Today, I was riding the train and someone farted. Everyone looked at me. People always blame farts on the fat guy. FML
by Banana / 12/04/2012 at 11:04am / Puerto Rico / Transportation
Today, I faced a dilemma. If I don't let the cat sleep in my bedroom, she spends all night howling at the door, waking up my 2-year-old in the process. If I do let her in, the dog gets distressed and chews the contents of the bin. If I let both of them in, I have no room to sleep. FML
by SweetheartSusie / 12/04/2012 at 4:19am / United Kingdom / Animals
Today, after having sex, my girlfriend left my apartment after furiously ranting at me, because I made her come "too many times" and that it's "unfair" to her. What? FML
by AllegroRubato / 12/04/2012 at 3:09pm / Chile (Region Metropolitana) / Intimacy
Today, my science class found out that I have OCD and that one of my rituals is to cough when others cough. This is going to be a long year. FML
by Anonymous / 12/04/2012 at 11:09pm / United States (New York) / Geek
Today, my girlfriend showed me a print of a Banksy that she'd just bought, telling me it was an original. When I tried to argue that it wasn't, she broke up with me for "implying she was a moron." FML
by Single / 12/04/2012 at 11:17am / United Kingdom (Bath and North East Somerset) / Love
Today, I ran into my high school crush at Target. When I asked her if she remembered me, she patted me on the head, said, "Unfortunately," and walked away. FML
by Likian5 / 12/04/2012 at 8:06pm / United States / Miscellaneous
Today, I walked into school confident about the new hair color I'd had done over the weekend. My drama teacher apparently dyed her hair the same color; everyone noticed and thought I'd copied her. FML
by Anonymous / 12/04/2012 at 12:01am / United States / Miscellaneous
Today, my elbow was having cramps and movement issues as a result of an old set of surgical pins and wires that are being rejected by my body. One painful twitch caused my arm to lock out straight, unintentionally slapping my hand into my co-worker's crotch. Our waiting customers giggled. FML
by SApprentice / 12/04/2012 at 2:10am / United States (Virginia) / Health
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- published: 13 Dec 2014
- views: 712
Radio is the use of radio waves is to carry information, such as sound, by systematically modulating some property of electromagnetic energy waves transmitted through space, such as their amplitude, frequency, phase, or pulse width. When radio waves strike an electrical conductor, the oscillating fields induce an alternating current in the conductor. The information in the waves can be extracted and transformed back into its original form.
Radio systems need a transmitter to modulate (change) some property of the energy produced to impress a signal on it, for example using amplitude modulation or angle modulation (which can be frequency modulation or phase modulation). Radio systems also need an antenna to convert electric currents into radio waves, and vice versa. An antenna can be used for both transmitting and receiving. The electrical resonance of tuned circuits in radios allow individual stations to be selected. The electromagnetic wave is intercepted by a tuned receiving antenna. A radio receiver receives its input from an antenna and converts it into a form usable for the consumer, such as sound, pictures, digital data, measurement values, navigational positions, etc. Radio frequencies occupy the range from a 3 kHz to 300 GHz, although commercially important uses of radio use only a small part of this spectrum.
Chelsea or Chelsey may refer to:
Chelsea Joy Handler (born February 25, 1975) is an American comedian, actress, writer, television host, and producer. She hosted a late-night talk show called Chelsea Lately on the E! network from 2007 to 2014, and released a documentary series, Chelsea Does, on Netflix in January 2016. In 2012, Time placed her on the list of its 100 Most Influential People.
Chelsea Joy Handler was born in Livingston, New Jersey, the youngest of six children of Rita (née Stoecker), a homemaker, and Seymour Handler, a used car dealer. Her American father is Jewish; her German-born mother, who came to the United States in 1958, was a Mormon. Her mother died of breast cancer in 2006. Handler was raised in Reform Judaism and had a Bat Mitzvah ceremony. She has said that while growing up she felt like an outsider, recalling, "We lived in this nice Jewish neighborhood...Everyone had Mercedes and Jaguars, and I was going to school in a Pinto."
Handler has two sisters and three brothers; her eldest brother, Chet, died in a hiking accident in the Grand Tetons in Wyoming when she was 9 years old. At age 19, she moved from New Jersey to Los Angeles, California, to pursue acting, and worked meanwhile as a waitress to support herself. At 21, Handler decided to pursue stand-up comedy after telling her story about a DUI to a class of other offenders, who found it funny.
Black people is a term used in certain countries, often in socially based systems of racial classification or of ethnicity, to describe persons who are perceived to be dark-skinned compared to other given populations. As such, the meaning of the expression varies widely both between and within societies, and depends significantly on context. For many other individuals, communities and countries, "black" is also perceived as a derogatory, outdated, reductive or otherwise unrepresentative label, and as a result is neither used nor defined.
Different societies apply differing criteria regarding who is classified as "black", and these social constructs have also changed over time. In a number of countries, societal variables affect classification as much as skin color, and the social criteria for "blackness" vary. For example, in North America the term black people is not necessarily an indicator of skin color or majority ethnic ancestry, but it is instead a socially based racial classification related to being African American, with a family history associated with institutionalized slavery. In South Africa and Latin America, for instance, mixed-race people are generally not classified as "black." In South Pacific regions such as Australia and Melanesia, European colonists applied the term "black" or it was used by populations with different histories and ethnic origin.


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Corey Perry's magical season reached another peak Wednesday when he scored a hat trick and his 50th goal in the Ducks' 6-2 thumping of San Jose.
Perry scored once in the first period and twice in the second amid chants of "M-V-P" at Honda Center. By the start of the third period, the Ducks were up 6-1 in a potential first-round playoff preview.
Only two other Ducks -- Teemu Selanne and Paul Kariya -- have scored as many as 50 goals in one season. Selanne was the last to do it, finishing 1997-98 with 52.
The Ducks remained seventh in the Western Conference with the victory, their 95 points matched by eighth-place Chicago; the Ducks have the tie-breaker over the Blackhawks. The Sharks are No. 2 in the West, one point ahead of Detroit.
Ryan Getzlaf had four assists and Bobby Ryan three in the victory. Selanne (29th goal), Cam Fowler (10th) and Jason Blake (16th) also scored for the Ducks.
Goalie Ray Emery left the game midway through the second period because of what the Ducks called "a minor injury." Team officials said he was cleared to return during the game, but Dan Ellis finished the rout.
After an off day Thursday, the Ducks conclude their regular season with a back-back, home-and-home pair against the L.A. Kings. The Southland rivals will meet Friday night at Honda Center and Saturday night at Staples Center.
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Kristen Stewart, Robert Pattinson Break Up 2013: Skipped Teen Choice Awards To Avoid Awkward Reunion? 'Twilight: Breaking Dawn Part 2' Wins Seven Surfboards, Including 'Best Romance'
By Staff Writer | August 12, 2013 10:44 AM EDT
Kristen Stewart and Robert Pattinson skipped the 2013 Teen Choice Awards Sunday night in California. Was it to avoid an awkward reunion after their public break up following a messy scandal? Their film "Twilight: Breaking Dawn Part 2" won seven awards at the TCAs, and Taylor Lautner, their co-star, was there to pick up a surfboard.
Contactmusic.com reports that, ironically, Kristen and Robert were nominated for "Best Romance" for their on-screen relationship as Bella and Edward in the final installment of the romantic vampire movie franchise. "Twilight: Breaking Dawn Part 2" was released last November, when the couple was still together, Entertainmentwise.com reports.
According to the website, the award for Choice Liplock, which the couple were up for and have won for the last four Twilight movies, has yet to be confirmed, despite the award show ending yesterday.
Kristen and Robert broke up in May of this year, and in just the few months between then and now, Rob has been linked to numerous women, though none of them officially confirmed. They include pop star Katy Perry, Elvis Presley's granddaughter Riley Keough, Aussie singer Sia Furler, and now "Machete Kills" actress, Michelle Rodriguez, according to Contactmusic.com reports.
The last installment of the Twilight saga won surf boards for Best Romance and Best Sci-Fi-Fantasy, The Inquisitr reports. Stewart won awards for Choice Movie Actress (Sci-Fi-Fantasy) and Choice Movie Actress (Romance).
Though Kristen and Rob avoided an awkward chance encounter, other Twilight stars were present on Sunday.
Co-star Taylor Lautner picked up a surf board for Choice Movie Actor (Sci-Fi/Fantasy). Kellan Lutz was also recognized for his role in "Twilight," and took home an award for Choice Movie Scene Stealer.
The night before the show, Rob was spotted out with Michelle Rodriguez at an afterparty for a screening of indie flick "It Felt Like Love," Hollywoodlife.com reports.
"Not gonna brag... but hanging out with Robert Pattinson, Marilyn Manson, and Kate Mara," one Twitter user posted about the party, according to Entertainmentwise.com.
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2016 Fantasy Football QB BUSTS: Yup Cam Newton Is On This List
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Last preseason, the Dolphins had thought they found the right fit at tight end in former New York Jets player Dustin Keller.
Keller was injured in a preseason game against Houston and never saw the field after only signing a 1-year contract. Charles Clay stepped in and played better than expected - winning over the coaching staff and the fans at Sun Life Stadium.
According to NFL.com and Chris Wesseling, the Dolphins appear to be looking at free agent Jermichael Finley to bolster their tight end unit.
The Miami Herald reports the Dolphins have had conversations with Finley's agent and might be interested if the tight end is cleared to resume his football career.
Coach Joe Philbin spent four seasons as Finley's offensive coordinator in Green Bay, so there's an obvious connection.
Piggybacking on the Miami Herald report, however, Dave Hyde of the South Florida Sun Sentinel cautions that the Dolphins' level of interest at this time is strictly of the "we-want-more-information" variety.
If Finley does gain medical clearance, Miami will consider a "low-dollars, low-risk" contract, per Hyde.
With both Clay, who played all over the field for the Dolphins in 2013 as a tight end, running back, fulback and goal line back, and Finley - who could give Miami a small boost and it would be a major plus, the Dolphins may have another new ofensive weapon to work into the new game plan for 2014.
The team also will not go above the $4.25 million contract they offered Keller last season. Seattle was the one team that appeared ready to make an offer to Finley early in fre agency, but since has backed off in its pursuit.
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Fail if cmake is not present.
Search Criteria
Package Details: screencloud 1.3.1-3
|Git Clone URL:
|https://aur.archlinux.org/screencloud.git (read-only)
|Package Base:
|Easy to use screenshot sharing application.
|Upstream URL:
|Last Packager:
|First Submitted:
|2012-09-24 12:40
|Last Updated:
|2016-08-21 11:24
Dependencies (8)
- hicolor-icon-theme
- pythonqt-qt5
- qt5-x11extras (qt5-x11extras-git)
- quazip-qt5
- xdg-utils (busking-git, linopen, mimi-git, sx-open, xdg-utils-git, xdg-utils-mimeo)
- cmake (make)
- qt5-tools (qt5-tools-git) (make)
- python-crypto (optional) – required for SFTP support
Required by (0)
Sources (1)
Latest Comments
grochat commented on 2016-08-21 10:34
SunRed commented on 2016-08-16 23:57
Error when opening with SFTP module installed - even with python-crypto:
Error in file: /home/XXX/.local/share/screencloud/ScreenCloud/plugins/sftp/main.py
Traceback (most recent call last):
File "<string>", line 5, in <module>
File "/home/XXX/.local/share/screencloud/ScreenCloud/plugins/sftp/modules/paramiko/__init__.py", line 30, in <module>
from paramiko.transport import SecurityOptions, Transport
File "/home/XXX/.local/share/screencloud/ScreenCloud/plugins/sftp/modules/paramiko/transport.py", line 50, in <module>
from paramiko.dsskey import DSSKey
File "/home/XXX/.local/share/screencloud/ScreenCloud/plugins/sftp/modules/paramiko/dsskey.py", line 26, in <module>
from Crypto.PublicKey import DSA
ImportError: No module named 'Crypto.PublicKey'
Bermond commented on 2015-11-12 19:27
I'm also getting this error when installing with packer:
error: 'screencloud-1.2.0-2-x86_64.pkg.tar.xz': duplicate target
lybin commented on 2015-10-30 23:57
If you know how to fix - show me diff. I don't use aura. Thank you.
s0r00t commented on 2015-10-30 18:17
Building fails with Aura, check https://github.com/aurapm/aura/issues/14.
"When I built it, I got this: error: '/var/cache/pacman/pkg/screencloud-1.2.0-1-64.pkg.tar.xz': duplicate target
Notice the difference? This file here is actually a source file, as defined in the PKGBUILD. After building, aura copies files that match .pkg.tar.xz and tries to install them. For this file to be named in the same way as built packages is the cause of the problem here."
lybin commented on 2015-02-15 15:31
orschiro commented on 2015-01-21 15:05
Should xrandr be a dependency? I get the following message during build process:
Checking for xrandr .. [failure]
remhume commented on 2014-06-14 13:35
i needed to install the package 'python2-crypto' additionally so that the SFTP-upload won't crash.
i guess that should be added to the dependencies - correct me if i'm wrong.
olav_st commented on 2014-03-31 18:10
Author here, just wanted to point out that some dependencies are no longer required. The current dependencies are: 'qt4' 'quazip' 'libqxt' 'python2' while 'python2-crypto' is optional.
kmicu commented on 2014-03-28 15:34
"skips validation because package updated, but version not changed"
It skips validation, because you have md5sums=('SKIP') in PKGBUILD.
You shoud have e.g. md5sums=('3dd2f2b7dc4e1859cfd13b16e0dc7cc7') (for current x86_64 version)
This is proper PKGBUILD's validation part with sums checking for current version:
"To ensure the security of pkgs submitted to the AUR please ensure that you have correctly filled the md5sum field. The md5sum's can be generated using the updpkgsums command." [1]
[1] https://wiki.archlinux.org/index.php/Arch_Packaging_Standards#Submitting_packages_to_the_AUR


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at LogRhythm (View all jobs) Boulder, CO LogRhythm is looking for a Professional Services Consultant who will be a vital member of LogRhythm?s customer care team. This individual will help drive the technical relationship with our enterprise customers and partners by providing7/5/2016 Boulder, CO Save This Job
Position Overview WE ARE SEEKING CANDIDATES WHO RESIDE IN DALLAS, HOUSTON, SAN ANTONIO OR AUSTIN. We are seeking a senior level Professional Services Consultant to accelerate our customer?s time to value, operational efficiency and ensure client success during trials and8/23/2016 San Diego, CA Save This Job
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Professional Services Seattle, Washington Apply Description Becoming a Professional Services Consulant (PSC) here at BrightEdge is the perfect position for you. You will be working directly with the largest companies in the world, helping them with their Digital Marketing8/16/2016 Seattle, WA Save This Job
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The Professional Services Principal Consultant is a technical leader within the Professional Services organization. Working in a post-sales setting directly with customers (both on-site and off-site) across different industries, technologies, and businessFlexible Location: Anywhere, remotely based
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You are here Home / Senior Consultant (Professional Services) (Full time; CA, OR, WA, UT) Industry: Computer Software Employment type: Full-time Experience: Senior Job function: Engineering,Customer Service Location: California, Oregon, Washington, Utah Overview: Lingotek is a6/28/2016 CA Save This Job
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ID 2016-2405 # of Openings 2 Job Locations US-MI-Grand Rapids Category Sales More information about this job: Who We Are: Love what you do and make a difference in people?s lives at CompHealth, a division of CHG Healthcare Services in Grand Rapids, MI. Join a fast-paced and6/27/2016 Grand Rapids, MI Save This Job
Computers/Software Dedham, MA, United States Microsoft SQL Server Database Consultant - must be legally authorized to work for any employer. Ntirety - The Database Experts. Become a member of our fast growing team. As a SQL Server Professional Services Consultant at Ntirety,6/28/2016 Dedham, MA Save This Job
Boulder, CO We are seeking a Support Services Engineer to join our team at our corporate office in Boulder, Colorado. We support nearly 1,500 global customers who are reliant on our software solution. This is an opportunity to enter into the exciting world of network security,7/5/2016 Boulder, CO Save This Job
Job ID 2016-1412 Job Location(s) US-Any More information about this job: Overview: It's not just clich-. The heart of Billtrust is its people. Our executives know it, our co-workers believe it, and our clients recognize it. Billtrust is enjoying remarkable success with 50%7/23/2016 Hamilton, NJ Save This Job


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