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We start a new feature here today, The World's Greatest Travelers™ tip of the day.
The idea is to impart on travelers everywhere a little unconventional wisdom, tips and
quotes that will hopfully increase your Travel IQ--or just have more fun traveling!
Occasionally they will be peppered with Top Ten Travel lists and useful quotes.
Comments welcome.
So here goes...
Day 80 Travel Tip of the Day:
Traveling as a foodie is one of the many delights of traveling the world.
People sharing meals is what "the good life" is all about. That said, cultures
have very different takes on food. Yes, it's just a matter of taste…but it is
my taste. Here are my choices for:
"World's Best Cuisine's:" "World's Worst Cuisine's:"
Italian Russian
Japanese Ethiopian
Thai Hungarian
American English
Indian Korean
French Nepali
Vietnamese Mongolian
Lebanese the Philippines
Mexican Israeli
Chinese Dutch
Day 79 Travel Tip of the Day:
Travel Tip #391 – When packing, I am passionate advocate of using Ziploc
freezer-type bags for everything. It may be the Holy Grail of Packing! I put
whole outfits (socks, t-shirts, dress shirts and pants) in one bag, sit on it to
suck the air out, and then seal it up. Boom. No wrinkles, no smells, no lack
of organization and rummage chaos. Great of course for all checked liquids
and shoes too. Then I pack a small garbage bag for the dirty laundry. Plastic
reusable bags people…the only way to go!
Day 78 Travel Tip of the Day:
South America is the Lost Continent for most North American travelers…no one
seems to go there. And it is there loss too because there is so much to see and
do: nature, vibrant culture, great urban centers and amazing food.
My Bakers Dozen South American Natural Wonders:
Andes Mountains
Angel Falls (Venezuela)
Colca Canyon (Peru)
Galapagos Islands (Ecuador)
Atacama Desert (Chile & Peru)
Iguassu/Iguazu Falls (Argentina & Brazil)
Salar de Uyuni (Bolivia)
Pantanal (Brazil)
Amazon Delta
Torres del Paine (Chile)
Grand Sabana (Venezuela)
Lake Titicaca (Peru & Bolivia)
Tierra del Fuego (Argentina)
Day 77 Travel Tip of the Day:
Travel Tip #472 – When packing a bag for a long adventure, put scented dryer
sheets that you use when drying laundry between your clothes in your suitcase.
It will keep clothes smelling fresh and clean while in transit. (Appearances and
odors are everything!)
Day 76 Travel Tip of the Day:
"Life is like riding a bicycle, to keep your balance you've got to keep moving." - Albert Einstein
Day 75 Travel Tip of the Day
Everybody love's beaches: white-sandy beaches, topless Teuton beaches,
secluded Robinson Crusoe-like beaches, party beaches, windsurfing beaches,
chic beaches, beach blanket bingo beaches, endless bleaches…
Here are a few of my Favorite International Beaches:
Anse Source (Seychelles)
Bondi Beach (Sydney, Australia)
Boracay Island (Philippines)
Ile Sainte Marie (Madagascar)
Matana Beach (Fiji)
Nha Trang (Vietnam)
Pantai Kecil-Little Beach (Bali, Indonesia)
Playa de la Soledad (Puerto Vallarta, Mexico)
Punta Uva Beach (Costa Rica)
Hamilton Island (Australia)
La Costa Beach (Malibu, USA)
Day 74 Travel Tip of the Day:
Travel Tip #183 - Planning, researching and organizing your trip will help you
get the most rest, relaxation and adventure out of any trip. What you put into
it--you will get out of it. It is much easier to unwind and explore when your trip
has a basic plan. Not planning on the other hand, will add unnecessary uncertainty
and stress to any trip. So save you family, friends and fellow travelers from going
postal on them--do your homework. (But not so much that your expectations
are overly inflated or that you don't allow for serendipity!)
Day 73 Travel Tip of the Day:
Terrible Travel Advice #176 – Buy really expensive luggage, it will last forever.
Gearing up for a road trip, adventure or trek is always fun; but don't buy expensive
luggage ( I have seen plenty of expensive luggage in pieces on luggage belts and
worse, mysteriously gone missing!) No, buy quality luggage. There doesn't seem to
be a relationship between luggage price and quality. Check the zippers and straps—those
are what matters. And although I prefer wheel bags, I also see the merit in getting wheel
bags with the option of using it as a backpack for when the road ends—and it does
eventually me! They end up easier to carry.
Day 72 Travel Tip of the Day:
The Travel Mindset #105 - Admittedly, travel is not always easy or perfect. But
consider this--the personal experiences you derive from travel will make you much
happier (and a more interesting person) in the long run than having more stuff.
Experiencing, learning and challenging yourself, are much better than buying,
consuming and acquiring.
Day 71 Travel Tip of the Day:
There are so many places see and things to do, more than 1,001 I am told (although my
list keeps getting longer ironically)…but here are ten things you really should experience
for yourself before you kick the bucket (in no particular order):
A Himalayan Sunrise (Nepal/Tibet)
Monument Valley Sunrise (USA)
Venice by water (Italy)
The Great Pyramid of Giza (Egypt)
Bagan Plains (Myanmar)
A sunset at Thira (Santorini, Greece)
Machu Picchu (Peru)
Angkor Wat (Cambodia)
Iguazu/Iguaçu Falls (Argentina/Brazil)
Scuba dive the Great Barrier Reef (Australia)
Day 70 Travel Tip of the Day:
Travel Tip #366 - If you are traveling with a partner, think about what stuff that you
can share with them. Why pack two of the same thing? And when traveling afar with
a partner for an extended time—or just a weekend away—split up your essential
stuff 50/50 into your two bags (aka cross packing)—that way if one bag is lost or
delayed, it less of a hassle because you still have stuff. ______________________________________________________________________
Day 69 Travel Tip of the Day:
Travel Tip #292 – We are big advocates of taking the kids when you travel afar;
yet managing them can be tricky. So, bribes, threats and extortion is the way to go!
We play the bribe game by offering treats--giving them a buck or two, an ice cream
or a special treat—whenever someone traveling tells us how great and polite they
are! Those "please" and "thank you's get them what they want.
Day 68 Travel Tip of the Day:
Travel Tip #178 - Before you head out on that grand international adventure, you
should make sure of a couple things in regards to your valid passport, as immigration
officials around the world are getting a little stuffy these days. One: Make sure that
your passport will not expire for six months after you enter the last country on you're
a trip. Tourist visas on arrival typically last 180 days and your passport needs to be
valid to get one. Two: Make sure that you have at least one clean empty page for
each country you are planning to visit for stamps and official whatnots (entry stamp,
visas, exit stamps, customs stamps, etc.)--at a minimum.
Day 67 Travel Tip of the Day:
Travel Tip #254 – Before you finally book your hotel, use Google Maps to check
out the area around the hotel. Location, location, location. Consider being nearby
a subway station—it can save you a lot of time and money. Are there any local
stores, restaurants or bars? How far away are you from the things you will want
to see and do? Saving $30 on a room for a weekend that is far away and costly to
travel to/from the places and things you want to see and do, is penny wish but pound
Google Maps is an absolutely revolutionary tool; ne that I am
constantly awestruck by the possibilities it presents. Use it often.
Day 66 Travel Tip of the Day:
"Travel...is not always the reward for financial success. Sometimes it furnishes
the source of one's wealth." - Robb Report
Day 65 Travel Tip of the Day:
Travel Tip #103 – When packing resist the urge to pack more than you
need "just in case". Because in the oft chance that you do get invited to a state
dinner, are asked to pose for a glossy magazine spread, or maybe are upgraded
into First Class because you were so nice to that gate agent (aka when "just in case"
happens)—just buy something new to wear! It will probably be cheaper and be a
future conversation piece too: "Oh this thing? I bought it at a store in Laos." Serious
travelers know, but neophytes should too, that they do have stores in the rest of the world.
And they do also do laundry in other countries too. We also live in the 21st century where
there are plenty of ways to check the weather at impending destinations and to pack
accordingly. Pack light, don't let a heavy load get you down. Less is more.
Day 64 Travel Tip of the Day:
Travel Tip #287 – Security folks always taking away your newly purchase, must
have in-flight, water? Take an empty refillable plastic bottle with you through TSA,
and just refill it in the terminal...saves you $3-5 bucks a pop. Plus you won't be adding
to land fill sites. I also fill them up on the plane during my flight—the flight attendants
never mind. You will always have water…err, except during security!
Day 63 Travel Tip of the Day:
Travel Tip #429 – If you are coming and going by train or bus from a single
destination? One way to save time, maybe money and ease your mind about
logistics, is that when you first arrive at a station quickly check the time tables
for your future departure options. It may show whether you need advance reservations,
what alternative timetables are and what track you would be leaving from, etc… Familiarize
yourself with all these. This saves a lot of needless Traveler's Panic when you are
departing in a rush and maybe another needless trip to the station.
Day 62 Travel Tip of the Day:
The Travel Tip #145 – This of course almost goes without saying, and yet I must
say it: If somebody offers up their home for you to use anywhere in the world--just
say yes! Build your trip around that destination using it as a base. It does not
matter where it is--go...experience their lives for a period of time.
Day 61 Travel Tip of the Day:
Travel Tip #356 - Want to fly a little better? On a long haul flight pre-order a
special meal (pasta, fish, vegan, whatever). This is a no-brainer, not only do you get
your food first, but they are usually a little better and healthier too!
Day 60 Travel Tip of the Day:
Terrible Travel Advice # 13 - "Once I was running late for a flight and couldn't find a
parking space, so I just left the car at the terminal departure curb. Yes, it got towed
away, but it was cheaper than missing my flight." A smart business calculaton if I ever heard.
Day 59 Travel Tip of the Day:
"Twenty years from now you will be more disappointed by the things that you
didn't do than by the ones you did so. So throw off the bowlines. Sail away
from the safe harbor. Catch the trade winds in your sails.
Explore. Dream. Discover." - Mark Twain
Day 58 Travel Tip of the Day
Travel Tip #291 - Don't backtrack. Satisfying traveling requires good time-management
and one of the worst uses of your time is backtracking. Create an itinerary that always
moves forward, onward to new destinations. Always be moving on to someplace new,
only to backtrack when necessary to return to your place of departure. But even that can
be fixed with good planning. Look for natural travel circles and travel triangles of off-the-beaten
path places to experience around and near your gateway cities.
Day 57 Travel Tip of the Day
The Travel Mindset #4 - Be a curious soul and develop and deep longing
to travel. A wise man once said, "The world is a book and those who do not
travel read only one page." Some would say travel is better than reading a good
book because it not only allows you to escape (not vicariously though) and personally
experience a whole new set of assumptions; all while creating your own narrative full
of drama, romance and adventure. There is no boring travel—just boring people. So
be curious, seek out the elusive. Go on a quest, fulfill a bucket list item, take a
pilgrimage, and just go on an adventure. Travel for whatever reason you want--but do travel!
Day 56 Travel Tip of the Day:
Travel Myth #3 - I'm too young to travel. Oh really, who said? If your parents will
let you and you're younger than 18--why not? Over 18, you don't need anyone's permission.
(Have you ever heard of any mode of public transportation that won't sell a ticket because
you're only 18? Me neither.) It may be the best education you ever get being able to worship
at the altar of experience. And travel is all about experience. In fact, it may be a case of now
or never for you too as you begin entering the trials and tribulations of adult responsibilities--
tomorrow may never come (school, adult responsibilities, debt, marriage, mortgage, kids…).
And in this ever-changing globalized world, the contacts, the insight and the context you will
garner from international travel will benefit you immensely. Beside, when you are young you
can embrace and tolerate a lot more discomfort and adversity--which make the costs of travel
even more feasible. Go now!
Day 55 Travel Tip of the Day:
Travel Myth #2 - I'm too old to travel. Oh really, who said? If your kids don't
need you around and you have the inclination, time and money--why not? It's
not like you need anyone's permission, right? That old cliché rings true for travelers
too: it doesn't matter how old you are, it only matters how old you feel. Think about
it; you followed the rules, did the requisite things in life that responsible citizens do:
high school (check), maybe college (check), a job for 40+ years (check),
husband/wife/mate/friends (check), maybe kids (check)--you paid your taxes and
your dues! Sure you won't have the same energy as a 21 year old and may not
want to deal with some of the discomforts of travel, but there are always ways around
that—and you have the acquired wisdom to figure it out. Life is short...and growing
shorter...it is a simple case of now or never. Enjoy!
Day 54 Travel Tip of the Day:
The Seven Deadly Sins of Travelers:
(Although envy, gluttony, greed, lust, pride, sloth and wrath still apply!)
1. Always looking for cheap;
2. Packing high expectations;
3. Putting off till tomorrow what you could do today;
4. Being a guest in a country and behaving badly…
5. Not doing enough prior research…
6. Being silly or drunk…or both!
7. Bad luck… wrong place at the wrong time not using your situational awareness!
Day 53 Travel Tip of the Day:
Travel Mindset #15 - Did you know that 85% of trips are taken to places that the travelers
have already been to—sometimes, over and over again. A curious, adventurous traveler
might consider trying someplace exciting and novel in order to expand their comfort zones.
You never feel more alive than when you challenge yourself.
"Once a year go someplace you have never been before." - Dalai Lama
Day 52 Travel Tip of the Day"
Travel Tip #380 – Your money is important--to you and in the places you spend it.
When traveling, especially in struggling destinations, make a small effort to
understand where your money spent is actually going. Is it staying in the country
or being exported? Is it going in a corporate brands coffers or recirculating in the
hands of locals? Try to leave as much as you can in-country--that makes the
tourism equation a virtuous cycle and more rewarding for all.
Day 51 Travel Tip of the Day:
Travel Advisory Tip #101 – I know it is your dream destination—Cork, Ireland—that
you saved and planned for years to visit. But do not, under any circumstances,
kiss the Cork institution known as the Blarney Stone (aka Stone of Eloquence)—unless
you want to kiss any of the other 1,000 or so other daily visitors who do. Yuck! It has
been affectionately called the Bacteria Stone by local guides; and it will only give you the
gift of herpes--not the Irish gift of gab. Be forewarned…
Day 50 Travel Tip of the Day:
Travel Tip #389 – Just a word to the wise when purchasing items in markets:
Never, ever, take currency/bills from a fish monger or off a fishing boat sales
person--it will stink up your pocket/wallet for days. Trust me on this one!
Day 49 Travel Tip of the Day:
Travel Tip #876 - Having the proper mindset when traveling is key; so don't expect
anything from the first and last days of your trip, vacation or adventure...they are to
and fro days, travel days...and are by design are usually NO FUN!
Get over it….don't complain, be happy you are traveling!
Day 48 Travel Tip of the Day:
"If you reject the food, ignore the customs, fear the religion and avoid the
people, you might better stay at home." - James Michener
Day 47 Travel Tip of the Day:
Travel Tip #444 – One of the biggest issues most travelers will suffer from is
"money illusion"--that causes you to overspend. Three things play into this illusion:
1) you think prices are the same as where you live (called purchasing power parity)—and
they usually are not!; 2) you don't know the real value of you money because you don't
know the "real" exchange rate—sometimes the street rate is a lot different from the
official bank rate; and 3) travelers forget all the fees associated with accessing their
money and making non-cash purchases: exchange fees, conversion fees, international
services and bank fees. The simple Rx: Check you card fees before you go, carry cash
and a calculator, or, better yet, a currency-conversion app.
Day 46 Travel Tip of the Day:
Travel Tip #954 – A great way to keep your recent travel memories alive
is to try recreating a memorable dish or meal that you had while traveling.
Food stores today sell all manner of specialty spices, exotic sauces and
global vegetables; so there's really no excuse why you can't try it at home.
You'd be surprised to—it might become a staple. (I think of Pho, Cuban
chicken, ceviche, pesto linguini, wiener schnitzel, beef Penang…) Make a
theme night of it and invite good friends for some future travel conversation.
Show them a few photos…but not all of them please!
Day 45 Travel Tip of the Day:
The Ten Commandments of The World's Greatest Travelers:
1) Thou shall leave thy expectations at home;
2) If thy cannot carry it—thy shalt not take it;
3) Be it that every destination be worth at least one visit—if only to know that
thy shall never wish to return to it;
4) Thee most interesting people you shall meet will be those trying to get at your
money, but remember that most of them are not trying to rip you off;
5) Thou shall seek out the transition zones, the places in between: borders,
sunrise/sunset, weather changes, nature, juxtapositions of old versus new,
morning and end of day routines, rituals, festivals, shore lines, etc., etc.;
6) Thou shall try new things all the time...even if only once;
7) Thou shall slow down and smell the divinity of the roses;
8) Thou shalt be curious, ask questions, listen, be humble and learn;
9) Thou shalt walk whenever thy can, mingle with the masses by taking public
10) Thou shall not pack thy fear and cynicism about your brothers and sisters of the world…be open and be gracious.
Day 44 Travel Tip of the Day:
Contrarian Traveler Tip #48 - When traveling the in-country, use guidebooks
as a good indicator of where not to go (too busy or touristy) and think about
stopping off at the nearest destination before or after the recommended hotspot.
Forget Malaga, Spain—try Ronda. Stay away from Kuta, Bali—try Ubud. The
same goes for countries too. Instead of Costa Rica--try Panama. Instead of
Hungary—try Romania. Instead of Vietnam—try Laos. Just think like a contrarian
and you will be great shape and get better value too; besides the hotspot is not too far away.
Day 43 Travel Tip of the Day:
Travel Paradox #14 – When you spend less you can travel longer--mileage may vary!
Day 42 Travel Tip of the Day:
Travel Tip #611 – Word to the wise: Never, ever ride an elephant in shorts….just
trust me on this one. Their cute, wrinkled skin is like sand paper. BTW: Little known
fact, that if want an elephant to remember you forever—just breathe into their
trunk…they now have your scent. Forever!
Day 41 Travel Tip of the Day:
"Better to ask twice than lose your way once." - Danish Proverb
Day 40 Travel Tip of the Day:
Travel Tip #210 - Choose your traveling friends slowly. Good things take time,
bad things happen quickly!
Day 39 Travel Tip of the Day:
Travel Tip #894 – A simple trick on how to avoid bringing a biological disaster home
when you buy a wooden object overseas is to place it in the freezer for a few of days.
Freezing kills whatever larvae that may be lurking within.
Day 38 Travel Tip of the Day:
"The more I traveled the more I realized that fear makes strangers of people
who should be friends." - Shirley MacLaine
Day 37 Travel Tip of the Day:
Contrarian Travel Tip #119 - Sleep outside whenever you can. Some of my most
memorable travels were had because I not scared of sleeping outside: in the desert,
on a longhouse balcony, on a beach, on a ship deck, on the balcony of your hotel
room, on a poolside deck chair, wherever…you will remember it forever!
Day 36 Travel Tip of the Day:
Travel Tip #821 - Want a good deal on an urban hotel for the weekend—Friday
and Saturday night? Find a large business hotel in the financial district of any
major town—they are usually somewhat empty on the weekends. Make a deal.
Day 35 Travel Tip of the Day:
Travel Tip #490 – Two things always make me feel like a million bucks when
I have inevitably succumbed to a dreaded Weary Traveler Flare-up: brushing
my teeth and changing my socks. Maybe it's just me, but others seem to
agree. Try it, you'll like it…
Day 34 Travel Tip of the Day:
Travel Tip #289 - Your mother was right of course--if you're not early, you're late!
Don't miss your flight. It can be costly both financially and time-wise in the long-run.
FYI: Nobel Prize-winning economist George Stigler has figured out the perfect time
to arrive at the airport to make a domestic fight--one and a half hours before your
flight (with a 5% margin of error that you will actually miss your flight). I will take that chance!
I say two hours for an international flight is plenty of time. Besides, if you never miss a
flight—you are spending way too much time in airports!
Day 33 Travel Tip of the Day:
The Four Essential Travel Truths:
There are four essential travel truths when preparing for a great trip, a new adventure
or just a quick fun vacation away, are: One) prior research; Two) adequate supplies
(the right stuff you'll actually need); Three) proper preparation; and Four) commonsense
(that comes from knowledge and experience). Any fool can travel, but a serious traveler knows
well these four essential travel truths.
Day 32 Travel Tip of the Day:
"Better to see something once than hear about it a thousand times." - Asian proverb
Day 31 Travel Tip if the Day:
Travel Myth #13 - You can fly for free as a Courier Service traveler. Not anymore, but
there was a day when seat-of-the pants air couriers accompanying time-sensitive
business cargo was a reality and it was cheap—but not free. Due to rapid globalization
of the air freight industry over the past two decades and with the growth of next-day
delivery companies like FedEx, UPS and Emory, the courier service angle is all but
non-existent nowadays. I hear that a few Colombia and Mexican drug lords are still
looking for mules though!
Day 30 Travel Tip of the Day:
Travel Tip #311 - Survey's vary, but 50% of travelers use four or more main
information sources when researching destinations: destination specific websites
lead the way (57% of sites visited), travel content sites second (55%), followed
by traveler review websites. I hear tell that the average person visits 21 sites during
nine sessions while preparing for a trip. Research is good, but don't get information
overload…and know that too much often contradictory information can lead to
paralysis—a symptom of decision fatigue. Manage your intake and stay with information
sources you have a good history with. BTW: before you actually book delete all your
cookies for the best possible deal—they know where you have been and what you
have been quoted!
Day 29 Travel Tip of the Day:
Travel Tip #128 - If you really must go to a theme park; Fridays are good days
to visit according to attendance records. And January and February may be the
best times to go—cool weather and the least crowded. Avoid them at all costs
between Memorial Day and Labor Day, as you are only setting yourself up for
bad times to come. Humorist Dave Barry may have set it best when he said,
"The best time to go to Disneyworld, if you want to avoid huge crowds, is 1962." Indeed.
Day 28 Travel Tip of the Day:
Traveler Paradox #1 - You either have all the time you need to travel but no money, or you have all the money you need to travel but no time. Go figure. Make time and be resourcesful...just go!
Day 27 Travel Tip of the Day:
A Few Things I Love about Traveling:
• lack of daily routine and being on a come-what-may travel schedule;
• out of comfort zone and default operating position;
• variety: new sights, new food, new cultures, new people;
• constant learning & always questioning your assumptions;
• feeling alive and in the moment and re-introducing yourself
to your five best friends—your senses!
• feeling the breeze on a boat traveling some exotic river;
• hearing my footsteps echo in a medieval cathedral;
• smelling the exotic spices walking through an ancient souk;
• hearing the clink of cocktail glasses and silverware in Venice;
• arriving with anticipation in a new destination;
• willingly getting up to watch the sunrise...in Bagan, among other begiling destinations.
Every momemt traveling is a present...and speaking of presents. Merry Christmas to all!
Day 26 Travel Tip of the Day:
"An adventure is like love - anticipated with pleasure, experienced with discomfort
and remembered with nostalgia." - Author Unknown
Day 25 Travel Tip of the Day:
Travel Tip #427 - Try having at least one progressive dinner whenever you are
in a different country. Start with drinks at one spot, then move on to appies at another
eatery, then try a main course someplace else, followed by dessert elsewhere. Okay,
then a night cap someplace fun. Make an evening out of it and explore…you will have a ton of fun.
Day 24 Travel Tip of the Day:
Terrible Travel Advice #88 - Don't talk to strangers. WTF? I know, your mom
taught you that when you were a preyed upon innocent in Fear Inc. (aka USA).
But now that you are a mature, smart, sophisticated and savvy traveler—please do
talk to strangers. Despite the evening news programs, you will find that humans around
the world are inherently kind...you can trust strangers in strange lands. In fact, ever
person you meet along the way is a potential friend and knowledgeable travel advisor.
(Just keep your talk/listen ratio in check.)
Day 23 Travel Tip of the Day:
Travel Tip #267 - Expert savvy travelers know that that admission price of
New York City museums is totally flexible and based on your willingness
to pay. Forget that suggested posted price...just name your price and they
will let you in. I promise. Yes, even for a buck!
Day 22 Travel Tip of the Day:
Travel Tip #688 – If you really must take a cruise, book the shore excursions
yourself (DIY) without the help of the cruiselines. It is really easy to do and book
them when you arrive with locals and you will save a ton of money, as well as
escape from all your cruise buddies for a day too! Shore excursions are huge
revenue streams for cruise lines and the markup is obscene. One friend told
me he booked a day to Angkor Wat for two for $3,500…in 15 minutes I had it
priced at $364--cars, guides, flighs, grand hotel. Nuff said, DIY!
Day 21 Travel Tip of the Day:
Travel Tip #233 - NEVER ever stick your thumb in the popular weeping column hole in
Hagia Sophia (Ayasofya) located in Istanbul, Turkey. There is no glory in the hole
as your finger will smell for days and you might consider cutting it off! Yucky.
Day 20 Travel Tip of the Day:
Travel Tip #401 - Always, repeat after me: always check your hotel and restaurant
bills...believe it or not, people have been known to pad the bills of customers they will
never see ever again! An extra side order here, a movie you didn't order there, an
extra beer…it all adds up! For some places--no names on the advice of
counsel--it seems that it is a business model.
Day 19 Travel Tip of the Day:
Travel Tip #873 – Whenever possible, always return home one full day before
you are required to jump back into action after a lengthy adventure. It gives you a short
breather and time to decompress, get reacquainted with loved ones, unload your bags,
open mail, get some familiar groceries, reflect a little, do laundry, and maybe get (or at
east try to get) a good night sleep too.
Day 18 Travel Tip of the Day:
Travel Tip #342 - Once home from your adventure, study your photos well,
especially your worst pictures—they are your best teachers of what to do and
what not to do. Learn from your mistakes. (Also, please, never show
all your photos to friends and family--keep the reject pile to yourself.)
Day 17 Travel Tip of the Day:
Travel Paradox #23 - Countries where people have smaller cars have much bigger
vacations than people in countries with bigger cars. Hmmm...you might be wrong Cadallic Man!
Day 16 Travel Tip of the Day:
"You have brains in your head. You have feet in your shoes. You can steer yourself any
direction you choose. You're on your own, and you know what you know. And you are
the one who'll decide where you'll go. Oh the places you'll go." - Dr. Seuss
Day 15 Travel Tip of the Day:
Travel Tip #101 – Remember that the bargains you obtain are only possible because of
low wages paid to the producers of goods and services in poorer places. Happily pay the
Gringo Tax cheerfully. Don't quibble over a few cents! Never try to cheat poor, ignorant
and desperate people. It is still a bargain for us. Karma...
Day 14 Travel Tip of the Day:
A few Travel Truisms:
-whenever you finally book, the price goes down the next day!
-planes are usually late departing—except when your flight is arriving a few minutes late...than
your connecting flights will be on time!
-you will always forget something that you should have remembered to bring on the way to the airport!
-your luggage always arrives last!
-housekeeping will always knock when you are napping or in the middle of, well, you know…
-despite weather forecast, you will experience bad weather on arrival!
-your camera will run out of batteries at the wrong time!
-your wakeup call will be late!
-you will arrive home before your postcards do!
-the more expensive the cost, the longer the TripAdvisor review!
Day 13 Travel Tip of theDay
Travel Tip #341– Yapta.com is a wonderfully subversive site for travelers in the market
to by airline tickets but want to hold off buying them until they are as cheap as possible.
And after you do purchase them, Yapta will notify you if the price drops and help you
get a refund too! (Yapta.com made the 101 Best Travel Websites for 2014!)
Day 12 (Happy Thanksgiving Day) Travel Tip of the Day
Travel Tip #45 - When your get the urge to go, start looking at a calendar and find a chuck of time.
Be flexible. To save money and avoid busy travel periods, be flexible. Here are few things to
consider: 1) The best time to travel is the so-called shoulder seasons (spring and fall before and
after the traditional summer vacation period) and between US thanksgiving and
Christmastime (aka Dead Week). 2) Conversely, unless you like crowds and over-paying, avoid
at all costs the Travel Bottleneck Periods, including: statutory long weekends (Easter weekend,
Memorial Day, Labor Day, Thanksgiving weekend, Christmas holidays) and the busy and expensive
summer holiday season (between Memorial and Labor Day weekends). 3) Remember important
family occasions like weddings, reunions, graduations and potential births. Find your sweet spot, circle the
calendar, commit to it and inform the boss.
Day 11 Travel Tip of the Day:
Travel Tip #444 - Avoid China's twin semi-annual Golden Weeks: Chinese Lunar New Year
in late January, and National Day usually early October. Again, everyone is off and moving...and
you have not seen a traffic jam until you see 1.3 billion people moving here and there. It is a
cluster fuck like you have never seen on par with India's every 12-year Kumbh Mela.
You have been warned.
Day 10 Travel Tip of the Day:
"I don't know what's worse: suffering homesickness when traveling or
wanderlust when not?" - William D. Chalmers
Day 9 Travel Tip of the Day:
Travel Tip #318 - Do you occasionally have a senior moment and forget your
hotel and/or room number--they all look alike, right? If you have a smartphone/digital
camera, take a photo of the front of your hotel...you will never have a problem explaining
to taxi drivers where you are staying again! Ditto your room.
Day 8 Travel Tip of the Day:
Travel Trip #564 - When in transit or just basically traveling, take to heart these three (okay four)
basic rules: never stand when you can sit, never sit when you can lie down, and never pass up a
chance to use the bathroom…and mostly never be without toilet paper in your daypack!
Day 7 Travel Tip of the Day:
Travel Tip #210 - Word to the wise: I always make sure that I leave my loved ones on the right terms.
Have great sex the night before you fly. Leave some fun notes for the kids. It will help everyone and
you will sleep better too. And just in case, their final memories of you are good.
Day 6 Travel Tip of the Day:
Travel Tip #345 – When booking anything, remember that everything is
always negotiable! Always ask, is that the best price today? Should I come back
tomorrow for a better price? They might offer you a "deal," seeing if you'll snatch
it while knowing it's not the lowest price they can offer. Always express hesitance
and wait for them to sell you. If you think you can do better, walk away saying you'll
have to think about it. Bottom line: Don't ever be afraid to ask; because as I tell my kids,
if you don't ask--you don't get! This works buying flights, booking hotel rooms, on rental
cars and markest the world over...don't be shy!
Day 5 Travel Tip of the Day:
"Travel has never been so urgent, even necessary, as it is today." - Pico Iyer
So much misunderstanding. So much ignorance. And yet we live in a highly interconnected globalized world.
A solution: Go travel!
Day 4 Travel Tip of the Day:
I am always asked simple questions; like which I would recommend
Either/Or? Here is my latest list of Either/Or choices I would choose:
JFK or EWR? (JFK)
Florida or Hawaii? (Hawaii)
Rome or Florence? (Florence)
LA or SF? (SF)
Paris or London? (Paris)
ATL or O'Hare? (ATL)
10 day trip or three 4-day trips? (10 day trips)
Louvre Musee or Musee O'rsay? (O'rsay)
Europe or Asia? (Asia)
Vienna or Berlin? (Vienna)
Croatia or Cinque de Terre? (Croatia)
Panama or Mexico? (Panama)
Hong Kong or Singapore? (HGK)
De Gaulle or Heathrow for connections? (De Gaulle)
Window or Aisle? (Window)
Turkey or Greece? (Turkey)
Prague or Budapest? (Budapest)
Australia or New Zealand? (NZ)
Beijing or Shanghai? (Beijing)
Dubai or Las Vegas? (Vegas...easier to get to and you can kiss in public!)
Bangkok or Singapore? (Bangkok)
Bali or Phuket? (Bali)
France or Italy? (Italy)
Amsterdam or Copenhagen? (Copenhagen)
7-day cruise or 7-day resort? (Resort)
Disneyland or Disney World? (Save your money & stay home)
Buenos Aries or Rio di Janeiro? (Rio)
Machu Picchu or Angkor Wat? (Machu Picchu)
Tanzania or Zambia? (Zambia)
Uganda or Angola? (Angola)
China or Vietnam? (Vietnam)
Nepal or Tibet? (Nepal)
…I could go on.
Day 3 Travel Tip of the Day:
Travel Myth #1 - There is a right way to travel. Wrong, there is no right way formula to travel. There is no cookie cutter one-size-fits-all approach to travel either. There is only your own personal Goldilocks Theory of Travel. Some folks love to sleep on the beach, while others are adrenaline junkies. Some are cheap and busy, others wealthy and lazy. Some like the tried and true and hang with the herd, while others head off to parts unknown by themselves. Some folks just need a few days, while others take a whole year off. There are no right ways to travel, and one way is not better than the other; it is wholly subjective, personal and an individual choice. Just like art. There's slow travel, hyper-travel, event travel, culinary travel, cultural travel, etc. I say, just travel.
Day 2 Travel Tip of the Day:
The Travel Mindset #1 - The hard fact of life is that you are only getting older and closer to death. Accept it. That said, YOLO (You Only Live Once)...now is the time to travel; not next year, not after you retire, not after the world goes to hell in a hand basket--now! Shit happens, and frankly, you never know where the roller coaster we call life will take you. As Woody Allen says, "If you want to make God laugh, tell him about your plans." So, planning a trip for a year from now is great, but don't put off travel as you and the world are rapidly changing…and it will only cost more later! No matter how short your trips, make taking them a lifelong habit.
Day One's nugget...and it is always best to start at the beginning I think:
"Life is either a daring adventure or nothing." - Helen Keller


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ESPNLast night was opening night in Major League Baseball (again). Only this time, it like something MLB has never seen before.
It was Miami being South Beach inside a baseball stadium.
It was over-the-top. It was hideous. It was a train wreck.
In other words, it was awesome in a way that only Miami can be.
On the next few pages, let's take a look at some of the crazier scenes from last night's inaugural game at the new Marlins Ballpark.
The new Miami Ballpark is like Mardi Gras on steroids.
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recipe reviews for:
"Strong coffee with sweetened condensed milk and chilled on ice makes an unbeatable Southeast Asian treat. Even those who only take their coffee black will like this. Serve it on hot summer days or as an evening treat. We learned this in Vietnam, and now drink almost all our espresso this way."
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Captain Buck (of moshi monsters) IS BACK! but only members can go and buy his treasures!
This time, he has lots of sweets! And he has got very messy! Unlike last time when he brought baths and showers and clean stuff, Just LOOK AT HIM!
He needs a bath!!!!!!
Maker of this blog


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Adjust all the details, but don't forget the big picture. That's the best conclusion you can draw from analyzing industry's most stunning cases of energy efficiency improvement. You can't hear it often enough: getting to know your production processes in a systematic and holistic way is essential. To harvest the full savings potential, all departments need to cooperate, including engineers, accoun...
Why should we even bother about recycling, when we could prevent waste in the first place? Well, according to the following study, published in May 2011, forget that question. Turn it around. We shouldn't even bother about waste prevention. Seeking a European Resource Efficiency Framework In an attempt to estimate the impact of policy efforts, the European Comission ordered several studies, aiming at the development of a frameweork contract for resource efficieny. The most interesting of all these studies is the analysis of the Key Contributions to Resource Efficiency. Three parties were inv...
In a satiric TV show on German TV the future for legislation after TTIP was described as a ...
ByMartina Prox, February 6, 2015The image at the start of this article should be accompanied by the caption "Leonardo Da V ...
ByDave Lisle, September 11, 2014After posting this article I came across a rather gloomy statistic that gives pause to tho ...
ByDave Lisle, August 20, 2014Hi! What do you think about the MA in sustainability science and policy at Maastricht Univ ...
Bylau, June 23, 2014Dear Moritz, Was hoping you could shed some light on the MSc offered at Cranfield Unive ...
Bydiego, June 18, 2014atmospheric carbon measurement
comparative life cycle assessment
corporate material flow modeling
Corporate Social Responsibility
customer-driven sustainability
energy efficiency in production
Environmental Goods and Services Sector
environmental management system
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environmental product declarations
environmental profit and loss statement
Environmental Sustainability Index
environmental technology verification
Environmentally Harmful Subsidy
Environmentally Weighed Material Consumption
European Green Cars Initiative
European Sustainable Development Strategy
internalization of externalities
mechanical-biological treatment
OECD Environment Policy Committee
Online Resource Efficiency Platform OREP
product environmental footprint
Production-based CO2 Productivity
remuneration of environmental performance
renewable energy in manufacturing


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Akrobatik - Alive
Artist: Akrobatik
Producer: Fakts One
Album: None (Promo Single)
Avg Rating: 3.6 ( 8 votes )
The Boston hip-hop community was hit hard early last year when Akrobatik, one of the city's most noted emcee's, suffered an aortic dissection (a condition in which there is a separation of the aorta walls). On his return record, which is fittingly-titled Alive, the New England spitter recounts his near tragic experience in vivid detail, from the phone call to 9-1-1 that he was barely able to make to the vital, emergency heart surgery that saved his life. The Fakts One-produced track, of course, doesn't pass without Akrobatik expressing his appreciation for those who kept him in mind, spitting, "And to each and everyone who said a prayer for me, shed a tear for me, maybe put one in the air for me/ All I can say is thanks for giving me strength." Alive is not (yet) attached to a project from the DJBooth favorite, but it does serve as a sort of cathartic, thank you to fans from an appreciative and very much alive emcee.
Written by Danielle H. on 10/4/12
Submit your Rating
Playaktion Recordings
First DJ Booth Appearance:
"Put Ya Stamp On It ft. Talib Kweli" (2008)
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Publications (262)792.01 Total impact
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ABSTRACT: Trichothecene mycotoxins, potent translational inhibitors that are associated with human food poisonings and damp-building illnesses, are of considerable concern to animal and human health. Food refusal is a hallmark of exposure of experimental animals to deoxynivalenol (DON) and other Type B trichothecenes but less is known about the anorectic effects of foodborne Type A trichothecenes (e.g., T-2 toxin, HT-2 toxin), airborne Type D trichothecenes (e.g. satratoxin G [SG]) or functionally analogous metabolites that impair protein synthesis. Here, we utilized a well-described mouse model of food intake to compare the anorectic potencies of T-2 toxin, HT-2 toxin, and SG to that of emetine, a medicinal alkaloid derived from ipecac that inhibits translation. Intraperitoneal (IP) administration with T-2 toxin, HT-2 toxin, emetine and SG evoked anorectic responses that occurred within 0.5 h that lasted up to 96, 96, 3 and 96 h, respectively, with lowest observed adverse effect levels (LOAELs) being 0.1, 0.1, 2.5 and 0.25 mg/kg BW, respectively. When delivered via natural routes of exposure, T-2 toxin, HT-2 toxin, emetine (oral) and SG (intranasal) induced anorectic responses that lasted up to 48, 48, 3 and 6 h, respectively with LOAELs being 0.1, 0.1, 0.25, and 0.5 mg/kg BW, respectively. All four compounds were generally much more potent than DON which was previously observed to have LOAELs of 1 and 2.5 mg/kg BW after IP and oral dosing, respectively. Taken together, these anorectic potency data will be valuable in discerning the relative risks from trichothecenes and other translational inhibitors of natural origin.Toxicology Reports 01/2015; 3. - [Show abstract] [Hide abstract]
ABSTRACT: The mycotoxin deoxynivalenol (DON) elicits robust anorectic and emetic effects in several animal species. However, less is known about the potential for naturally-occurring and synthetic congeners of this trichothecene to cause analogous responses. Here we tested the hypothesis that alterations in DON structure found in the plant metabolite deoxynivalenol-3-glucoside (D3G) and two pharmacologically active synthetic DON derivatives, EN139528 and EN139544 differentially impact their potential to evoke food refusal and emesis. In a nocturnal mouse food consumption model, oral administration with DON, D3G, EN139528 or EN139544 at doses from 2.5 to 10 mg/kg BW induced anorectic responses that lasted up to 16, 6, 6 and 3 h, respectively. Anorectic potency rank orders were EN139544>DON>EN139528>D3G from 0 to 0.5 h but DON>D3G>EN139528>EN139544 from 0 to 3 h. Oral exposure to each of the four compounds at a common dose (2.5 mg/kg BW) stimulated plasma elevations of the gut satiety peptides cholecystokinin and to a lesser extent, peptide YY3-36 that corresponded to reduced food consumption. In a mink emesis model, oral administration of increasing doses of the congeners differentially induced emesis, causing marked decreases in latency to emesis with corresponding increases in both duration and number of emetic events. The minimum emetic doses for DON, EN139528, D3G and EN139544 were 0.05, 0.5, 2, and 5 mg/kg BW, respectively. Taken together, the results suggest that while all three DON congeners elicited anorectic responses that mimicked DON over a narrow dose range, they were markedly less potent than the parent mycotoxin at inducing emesis.Toxicological Sciences 08/2014; · 4.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mortality from systemic lupus erythematosus (SLE), a prototypical autoimmune disease, correlates with the onset and severity of kidney glomerulonephritis. There are both preclinical and clinical evidence that SLE patients may benefit from consumption of n-3 polyunsaturated fatty acids (PUFA) found in fish oil, but the mechanisms remain unclear. Here we employed the NZBWF1 SLE mouse model to compare the effects of dietary lipids on the onset and severity of autoimmune glomerulonephritis after consuming: 1) n-3 PUFA-rich diet containing docosahexaenoic acid-enriched fish oil (DFO), 2) n-6 PUFA-rich Western-type diet containing corn oil (CRN) or 3) n-9 monounsaturated fatty acid (MUFA)-rich Mediterranean-type diet containing high oleic safflower oil (HOS). Elevated plasma autoantibodies, proteinuria and glomerulonephritis were evident in mice fed either the n-6 PUFA or n-9 MUFA diets, however, all three endpoints were markedly attenuated in mice that consumed the n-3 PUFA diet until 34 wk of age. A focused PCR array was used to relate these findings to the expression of 84 genes associated with CD4+ T cell function in the spleen and kidney both prior to and after the onset of the autoimmune nephritis. n-3 PUFA suppression of autoimmunity in NZBWF1 mice was found to co-occur with a generalized downregulation of CD4+ T cell-related genes in kidney and/or spleen at wk 34. These genes were associated with the inflammatory response, antigen presentation, T cell activation, B cell activation/differentiation and leukocyte recruitment. Quantitative RT-PCR of representative affected genes confirmed that n-3 PUFA consumption was associated with reduced expression of CD80, CTLA-4, IL-10, IL-18, CCL-5, CXCR3, IL-6, TNF-α and osteopontin mRNAs in kidney and/or spleens as compared to mice fed n-6 PUFA or n-9 MUFA diets. Remarkably, many of the genes identified in this study are currently under consideration as biomarkers and/or biotherapeutic targets for SLE and other autoimmune diseases.PLoS ONE 06/2014; 9(6):e100255. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The foodborne mycotoxin deoxynivalenol (DON) induces a ribotoxic stress response in mononuclear phagocytes that mediate aberrant multi-organ upregulation of TNF-α, interleukins and chemokines in experimental animals. While other DON congeners also exist as food contaminants or pharmacologically-active derivatives, it is not known how these compounds affect expression of these cytokine genes in vivo. To address this gap, we compared in mice the acute effects of oral DON exposure to that of seven relevant congeners on splenic expression of representative cytokine mRNAs after 2 and 6h. Congeners included the 8-ketotrichothecenes 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), fusarenon X (FX), nivalenol (NIV), the plant metabolite DON-3-glucoside (D3G) and two synthetic DON derivatives with novel satiety-inducing properties (EN139528 and EN139544). DON markedly induced transient upregulation of TNF-α IL-1β, IL-6, CXCL-2, CCL-2 and CCL-7 mRNA expression. The two ADONs also evoked mRNA expression of these genes but to a relatively lesser extent. FX induced more persistent responses than the other DON congeners and, compared to DON, was: 1) more potent in inducing IL-1β mRNA, 2) approximately equipotent in the induction of TNF-α and CCL-2 mRNAs, and 3) less potent at upregulating IL-6, CXCL-2, and CCL-2 mRNAs. EN139528's effects were similar to NIV, the least potent 8-ketotrichothecene, while D3G and EN139544 were largely incapable of eliciting cytokine or chemokine mRNA responses. Taken together, the results presented herein provide important new insights into the potential of naturally-occurring and synthetic DON congeners to elicit aberrant mRNA upregulation of cytokines associated with acute and chronic trichothecene toxicity.Toxicology and Applied Pharmacology 04/2014; · 3.98 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mycotoxins are toxic and carcinogenic metabolites produced by fungi that colonize food crops. The most agriculturally important mycotoxins known today are aflatoxins, which cause liver cancer and have also been implicated in child growth impairment and acute toxicoses; fumonisins, which have been associated with esophageal cancer (EC) and neural tube defects (NTDs); deoxynivalenol (DON) and other trichothecenes, which are immunotoxic and cause gastroenteritis; and ochratoxin A (OTA), which has been associated with renal diseases. This review describes the adverse human health impacts associated with these major groups of mycotoxins. First, we provide background on the fungi that produce these different mycotoxins and on the food crops commonly infected. Then, we describe each group of mycotoxins in greater detail, as well as the adverse effects associated with each mycotoxin and the populations worldwide at risk. We conclude with a brief discussion on estimations of global burden of disease caused by dietary mycotoxin exposure. Expected final online publication date for the Annual Review of Food Science and Technology Volume 5 is February 28, 2014. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.Review of Food Science and Technology 01/2014; · 5.98 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Cereal grain contamination by trichothecene mycotoxins is known to negatively impact human and animal health with adverse effects on food intake and growth being of particular concern. The head blight fungus Fusarium graminearum elaborates five closely related 8-ketotrichothecene congeners: (1) deoxynivalenol (DON), (2) 3-acetyldeoxynivalenol (3-ADON), (3) 15-acetyldeoxynivalenol (15-ADON), (4) fusarenon X (FX) and nivalenol (NIV). While anorexia induction in mice exposed intraperitoneally to DON has been linked to plasma elevation of the satiety hormones cholecystokinin (CCK) and peptide YY3-36 (PYY3-36), the effects of oral gavage of DON or of other 8-keotrichothecenes on release of these gut peptides have not been established. The purpose of this study was to (1) compare the anorectic responses to the aforementioned 8-ketotrichothecenes following oral gavage at a common dose (2.5 mg/kg BW) and (2) relate these effects to changes plasma CCK and PYY3-36 concentrations. Elevation of plasma CCK markedly corresponded to anorexia induction by DON and all other 8-ketotrichothecenes tested. Furthermore, the CCK1 receptor antagonist SR 27897 and the CCK2 receptor antagonist L-365,260 dose-dependently attenuated both CCK- and DON-induced anorexia, which was consistent with this gut satiety hormone being an important mediator of 8-ketotrichothecene-induced food refusal. In contrast to CCK, PYY3-36 was moderately elevated by oral gavage with DON and NIV but not by 3-ADON, 15-ADON or FX. Taken together, the results suggest that CCK plays a major role in anorexia induction following oral exposure to 8-ketotrichothecenes, whereas PYY3-36 might play a lesser, congener-dependent role in this response.Toxicological Sciences 01/2014; · 4.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The foodborne mycotoxin deoxynivalenol (DON) induces a ribotoxic stress response in mononuclear phagocytes that mediate aberrant multi-organ upregulation of TNF-α, interleukins and chemokines in experimental animals. While other DON congeners also exist as food contaminants or pharmacologically-active derivatives, it is not known how these compounds affect expression of these cytokine genes in vivo. To address this gap, we compared in mice the acute effects of oral DON exposure to that of seven relevant congeners on splenic expression of representative cytokine mRNAs after 2 and 6 h. Congeners included the 8-ketotrichothecenes 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), fusarenon X (FX), nivalenol (NIV), the plant metabolite DON-3-glucoside (D3G) and two synthetic DON derivatives with novel satiety-inducing properties (EN139528 and EN139544). DON markedly induced transient upregulation of TNF-α IL-1β, IL-6, CXCL-2, CCL-2 and CCL-7 mRNA expression. The two ADONs also evoked mRNA expression of these genes but to a relatively lesser extent. FX induced more persistent responses than the other DON congeners and, compared to DON, was: 1) more potent in inducing IL-1β mRNA, 2) approximately equipotent in the induction of TNF-α and CCL-2 mRNAs, and 3) less potent at upregulating IL-6, CXCL-2, and CCL-2 mRNAs. EN139528's effects were similar to NIV, the least potent 8-ketotrichothecene, while D3G and EN139544 were largely incapable of eliciting cytokine or chemokine mRNA responses. Taken together, the results presented herein provide important new insights into the potential of naturally-occurring and synthetic DON congeners to elicit aberrant mRNA upregulation of cytokines associated with acute and chronic trichothecene toxicity.Toxicology and Applied Pharmacology 01/2014; · 3.63 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Deoxynivalenol (DON), a trichothecene mycotoxin produced by Fusarium that commonly contaminates cereal-based food, interacts with the ribosome to cause translation inhibition and activate stress kinases in mononuclear phagocytes via the ribotoxic stress response (RSR). The goal of this study was to test the hypothesis that the ribosome functions as a platform for spatiotemporal regulation of translation inhibition and RSR. Specifically, we employed stable isotope labeling of amino acids in cell culture (SILAC)-based proteomics to quantify the early (≤ 30 min) DON-induced changes in ribosome-associated proteins in RAW 264.7 murine macrophage. Changes in the proteome and phosphoproteome were determined using off-gel isoelectric focusing and titanium dioxide chromatography, respectively, in conjunction with LC-MS/MS. Following exposure of RAW 264.7 to a toxicologically relevant concentration of DON (250 ng/mL), we observed an overall decrease in translation-related proteins interacting with the ribosome, concurrently with a compensatory increase in proteins that mediate protein folding, biosynthesis, and cellular organization. Alterations in the ribosome-associated phosphoproteome reflected proteins that modulate translational and transcriptional regulation, and others that converged with signaling pathways known to overlap with phosphorylation changes characterized previously in intact RAW 264.7 cells. These results suggest that the ribosome plays a central role as a hub for association and phosphorylation of proteins involved in the coordination of early translation inhibition as well as recruitment and maintenance of stress-related proteins - both of which enable cells to adapt and respond to ribotoxin exposure. This study provides a template for elucidating the molecular mechanisms of DON and other ribosome-targeting agents.Toxicological Sciences 11/2013; · 4.48 Impact Factor -
Article: Early Phosphoproteomic Changes in the Mouse Spleen during Deoxynivalenol-Induced Ribotoxic Stress.
[Show abstract] [Hide abstract]
ABSTRACT: The trichothecene mycotoxin deoxynivalenol (DON) targets the innate immune system and is of public health significance because of its frequent presence in human and animal food. DON-induced proinflammatory gene expression and apoptosis in the lymphoid tissue have been associated with a ribotoxic stress response (RSR) that involves rapid phosphorylation of mitogen-activated protein kinases (MAPKs). To better understand the relationship between protein phosphorylation and DON's immunotoxic effects, stable isotope dimethyl labeling-based proteomics in conjunction with titanium dioxide chromatography was employed to quantitatively profile the immediate (≤30 min) phosphoproteome changes in the spleens of mice orally exposed to 5 mg/kg body weight DON. A total of 90 phosphoproteins indicative of novel phosphorylation events were significantly modulated by DON. In addition to critical branches and scaffolds of MAPK signaling being affected, DON exposure also altered phosphorylation of proteins that mediate PI3K/AKT pathways. Gene ontology analysis revealed that DON exposure affected biological processes such as cytoskeleton organization, regulation of apoptosis, and lymphocyte activation and development, which likely contribute to immune dysregulation associated with DON-induced RSR. Consistent with these findings, DON impacted phosphorylation of proteins within diverse immune cell populations, including monocytes, macrophages, T cells, B cells, dendritic cells and mast cells. Fuzzy c-means clustering analysis further indicated that DON evoked several distinctive temporal profiles of regulated phosphopeptides. Overall, the findings from this investigation can serve as a template for future focused exploration and modeling of cellular responses associated with the immunotoxicity evoked by DON and other ribotoxins.Toxicological Sciences 06/2013; · 4.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The trichothecene deoxynivalenol (DON), a potent ribotoxic mycotoxin produced by the cereal blight fungus Fusarium graminearum, commonly contaminates grain-based foods. Oral exposure to DON causes decreased food intake, reduced weight gain and body weight loss in experimental animals - effects that have been linked to dysregulation of hormones responsible for mediating satiety at the central nervous system level. When diet-induced obese (DIO) mice are fed DON, they consume less food, eventually achieving body weights of control diet-fed mice. Here, we extended these findings by characterizing: 1) reversibility of DON-induced body weight loss and anorexia in DIO mice and 2) the role of double-stranded RNA-activated protein kinase (PKR) which has been previously linked to initiation of the ribotoxic stress response. The results demonstrated that DON-induced weight loss was reversible in DIO mice and this effect corresponded to initiation of a robust hyperphagic response. When DIO mice deficient in PKR were exposed to DON, they exhibited weight suppression similar to DIO wild-type fed the toxin, suggesting the toxin's weight effects were not dependent on PKR. Taken together, DON's effects on food consumption and body weight are not permanent and, furthermore, PKR is not an essential signaling molecule for DON's anorectic and weight effects.Toxicology Letters 05/2013; · 3.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Deoxynivalenol (DON, vomitoxin), a trichothecene mycotoxin produced by Fusarium sp. that frequently occurs in cereal grains, has been associated with human and animal food poisoning. Although a common hallmark of DON-induced toxicity is rapid onset of emesis, the mechanisms for this adverse effect are not fully understood. Recently our laboratory has demonstrated that the mink (Neovison vison) is a suitable small animal model for investigating trichothecene-induced emesis. The goal of the present study was to use this model to determine the roles of two gut satiety hormones, peptide YY3-36 (PYY3-36) and cholecystokinin (CCK), and the neurotransmitter 5-hydroxytryptamine (5-HT) in DON-induced emesis. Following intraperitoneal exposure to DON at 100 and 250 ug/kg bw, emesis induction ensued within 15 to 30 min and then persisted up to 120 min. Plasma DON measurement revealed that this emesis period correlated with the rapid distribution and clearance of the toxin. Significant elevations in both plasma PYY3-36 (30 to 60 min) and 5-HT (60 min) but not CCK were observed during emesis. Pretreatment with the neuropeptide Y receptor 2 antagonist JNJ-31020028 attenuated DON- and PYY-induced emesis whereas the CCK1 receptor antagonist devezapide did not alter DON's emetic effects. The 5-HT3 receptor antagonist granisetron completely suppressed induction of vomiting by DON and the 5-HT inducer cisplatin. Granisetron pretreatment also partially blocked PYY3-36-induced emesis suggesting a potential upstream role for this gut satiety hormone in 5-HT release. Taken together, the results suggest that both PYY3-36 and 5-HT play contributory roles in DON-induced emesis.Toxicological Sciences 03/2013; · 4.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The mycotoxin alternariol (AOH), a frequent contaminant in fruit and cereal products, is known to induce DNA damage with subsequent cell cycle arrest. Here we elucidated the effects of AOH on stages of cell cycle progression using the RAW 264.7 macrophage model. AOH resulted in an accumulation of cells in the G2/M-phase (4N). Most cells exhibited a large G2 nucleus whereas numbers of true mitotic cells were reduced relative to control. Both cyclin B1 and p-cdc2 levels increased, while cyclin B1 remained in the cytoplasm; suggesting arrest in the G2/M transition point. Remarkably, after exposure to AOH for 24h, most of the cells exhibited abnormally shaped nuclei, as evidenced by partly divided nuclei, nuclear blebs, polyploidy and micronuclei (MN). AOH treatment also induced abnormal Aurora B bridges, suggesting that cytokinesis was interfered within cells undergoing karyokinesis. A minor part of the resultant G1 tetraploid (4N) cells re-entered the S-phase and progressed to 8N cells.Toxicology Letters 02/2013; · 3.36 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Deoxynivalenol (DON), a trichothecenemycotoxin produced by Fusarium that commonly contaminates food, is capable of activating mononuclear phagocytes of the innate immune system via a process termed the ribotoxic stress response (RSR). To encapture global signaling events mediating RSR, we quantified the early temporal (≤30min) phosphoproteome changes that occurred in RAW 264.7 murine macrophage during exposure to a toxicologically relevant concentration of DON (250ng/mL). Large-scale phosphoproteomic analysis employing stable isotope labeling of amino acids in cell culture (SILAC) in conjunction with titanium dioxide chromatography revealed that DON significantly upregulated or downregulated phosphorylation of 188 proteins at both known and yet-to-be functionally characterized phosphosites. DON-induced RSR is extremely complex and goes far beyond its prior known capacity to inhibit translation and activate MAPKs. Transcriptional regulation was the main target during early DON-induced RSR, covering over 20 percent of the altered phosphoproteins as indicated by Gene Ontology annotation and including transcription factors/cofactors and epigenetic modulators. Other biological processes impacted included cell cycle, RNA processing, translation, ribosome biogenesis, monocyte differentiation and cytoskeleton organization. Some of these processes could be mediated by signaling networks involving MAPK-, NFκB-, AKT- and AMPK-linked pathways. Fuzzy c-means clustering revealed that DON-regulated phosphosites could be discretely classified with regard to the kinetics of phosphorylation/dephosphorylation. The cellular response networks identified provide a template for further exploration of the mechanisms of trichothecenemycotoxins and other ribotoxins, and ultimately, could contribute to improved mechanism-based human health risk assessment.Toxicology and Applied Pharmacology 01/2013; · 3.98 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Consumption of the trichothecene deoxynivalenol (DON) suppresses growth in experimental animals - an adverse effect that was used to establish the tolerable daily intake for this toxin. DON ingestion has been recently found to suppress plasma insulin-like growth factor acid-labile subunit (IGFALS), a protein essential for growth. Studies were conducted to explore the feasibility of using plasma IGFALS as a biomarker of effect for DON. In the first study, weanling mice were fed 0, 1, 2.5, 5 and 10ppm DON and weight and plasma IGFALS determined at intervals over 9 wk. Reduced body weight gains were detectable beginning at wk 5 in the 10ppm dose and wk 7 at the 5ppm dose. Plasma IGFALS was significantly depressed at wk 5 in the 5 and 10ppm groups at wk 9 in the 10ppm group. Depressed IGFALS significantly correlated with reduced body weight at wk 5 and 9. Benchmark dose modeling revealed the BMDL and BMD for plasma IGFALS reduction were 1.1 and 3.0ppm DON and for weight reduction were 2.1 and 4.5ppm DON. In the second study, it was demonstrated that mice fed 15ppm DON diet had significantly less plasma IGFALS than mice fed identical amounts of control diet. Thus DON's influence on IGFALS likely reflects the combined effects of reduced food intake as well as its physiological action involving suppressors of cytokine signaling. Taken together, these findings suggest that plasma IGFALS might be a useful biomarker for DON's adverse effects on growth.Toxicology 01/2013; · 3.75 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Alternariol (AOH), a mycotoxin produced by Alternaria sp, is often found as a contaminant in fruit and cereal products. Here we employed the murine macrophage cell line RAW 264.7 to test the hypothesis that AOH causes toxicity as a response to DNA damage. AOH at concentrations of 15-30μM almost completely blocked cell proliferation. Within 30min treatment, AOH (30μM) significantly increased the level of reactive oxygen species (ROS). Furthermore, DNA base oxidations as well as DNA strand breaks and/or alkaline labile sites were detected by the comet assay after 2h exposure of AOH. Cell death (mostly necrosis) was observed after prolonged exposure to the highest concentration of AOH (60μM for 24 and 48h) in our study. The DNA damage response involved phosphorylation (activation) of histone H2AX and check point kinase-1- and 2 (Chk-1/2). Moreover, AOH activated p53 and increased the expression of p21, Cyclin B, MDM2, and Sestrin 2; likewise the level of several miRNA was affected. AOH-induced Sestrin 2 expression was regulated by p53 and could at least partly be inhibited by antioxidants, suggesting a role of ROS in the response. Interestingly, the addition of antioxidants did not inhibit cell cycle arrest. Although the formation of ROS by itself was not directly linked cell proliferation, AOH-induced DNA damage and resulting transcriptional changes in p21, MDM2, and Cyclin B likely contribute to the reduced cell proliferation; while Sestrin 2 would contribute to the oxidant defense.Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 09/2012; · 4.44 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The Type B trichothecene deoxynivalenol (DON), a ribotoxic mycotoxin known to contaminate cereal-based foods, induces ribosomal RNA (rRNA) cleavage in the macrophage via p38-directed activation of caspases. Here we employed the RAW 264.7 murine macrophage model to test the hypothesis that this rRNA cleavage pathway is similarly induced by other ribotoxins. Capillary electrophoresis confirmed that the antibiotic anisomycin (≥25ng/ml), the macrocylic trichothecene satratoxin G (SG) (≥10ng/ml) and ribosome-inactivating protein ricin (≥300ng/ml) induced 18s and 28s rRNA fragmentation patterns identical to that observed for DON. Also, as found for DON, inhibition of p38, double-stranded RNA-activated kinase (PKR) and hematopoietic cell kinase (Hck) suppressed MAPK anisomycin-induced rRNA cleavage, while, in contrast, their inhibition did not affect SG- and ricin-induced rRNA fragmentation. The p53 inhibitor pifithrin-μ and pan caspase inhibitor Z-VAD-FMK suppressed rRNA cleavage induced by anisomycin, SG and ricin, indicating that these ribotoxins shared with DON a conserved downstream pathway. Activation of caspases 8, 9 and 3 concurrently with apoptosis further suggested that rRNA cleavage occurred in parallel with both extrinsic and intrinsic pathways of programmed cell death. When specific inhibitors of cathepsins L and B (lysosomal cysteine cathepsins active at cytosolic neutral pH) were tested, only the former impaired anisomycin-, SG-, ricin- and DON-induced rRNA cleavage. Taken together, the data suggest that (1) all four ribotoxins induced p53-dependent rRNA cleavage via activation of cathepsin L and caspase 3, and (2) activation of p53 by DON and anisomycin involved p38 whereas SG and ricin activated p53 by an alternative mechanism.Toxicology and Applied Pharmacology 09/2012; · 3.98 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: While the acute toxic effects of the trichothecene mycotoxin deoxynivalenol (DON or vomitoxin), a known cause of human food poisoning, have been well-characterized in several animal species, much less is known about closely related 8-ketotrichothecenes that similarly occur in cereal grains colonized by toxigenic fusaria. To address this, we compared potencies of DON, 15-acetyldeoxynivalenol (15-ADON), 3-acetyldeoxynivalenol (3-ADON), fusarenon X (FX) and nivalenol (NIV) in the mink emesis model following intraperitoneal (ip) and oral administration. All five congeners dose-dependently induced emesis by both administration methods. With increasing doses, there were marked decreases in latency to emesis with corresponding increases in emesis duration and number of emetic events. The effective doses resulting in emetic events in 50% of the animals (EDs(50)) for ip exposure to DON, 15-ADON, 3-ADON, FX and NIV were 80, 170, 180, 70, and 60 µg/kg bw respectively, and for oral exposure were 30, 40, 290, 30 and 250 µg/kg bw, respectively. The emetic potency of DON determined here was comparable to that reported in analogous studies conducted in pigs and dogs suggesting that the mink is a suitable small animal model for investigating acute trichothecene toxicity. The use of a mouse pica model, based on the consumption of kaolin, was also evaluated as a possible surrogate for studying emesis but was found unsuitable. From a public health perspective, comparative emetic potency data derived from small animal models such as the mink should be useful for establishing toxic equivalency factors for DON and other trichothecenes.Toxicological Sciences 09/2012; · 4.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: The trichothecene deoxynivalenol (DON), a common contaminant of cereal-based foods, is a ribotoxic mycotoxin known to activate innate immune cells in vivo and in vitro. While it is recognized that DON induces transcription and mRNA stability of inflammation-associated mRNAs in mononuclear phagocytes, it is not known if this toxin affects translation of selected mRNA species in the cellular pool. To address this question, we employed a focused inflammation/autoimmunity PCR array to compare DON-induced changes in profiles of polysome-associated mRNA transcripts (translatome) to total cellular mRNA transcripts (transcriptome) in the RAW 264.7 murine macrophage model. Exposure to DON at 250 ng/ml (0.84 μM) for 6 h induced robust expression changes in inflammatory response genes including cytokines, cytokine receptors, chemokines, chemokine receptors, and transcription factors, with 73% of the changes being highly comparable within transcriptome and translatome populations. When expression changes of selected representative inflammatory response genes in the polysome and cellular mRNA pools were quantified in a follow-up study by real-time PCR, closely coordinated regulation of the translatome and transcriptome was confirmed, however, modest but significant differences in the relative expression of some genes within the two pools were also detectable. Taken together, DON's capacity to alter translation expression of inflammation-associated genes appears to be driven predominantly by selective transcription and mRNA stabilization that have been reported previously, however, a small subset of these genes appear to be further regulated at the translational level.Toxicological Sciences 09/2012; · 4.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Consumption of deoxynivalenol (DON), a trichothecene mycotoxin known to commonly contaminate grain-based foods, suppresses growth of experimental animals, thus raising concerns over its potential to adversely affect young children. While this growth impairment is believed to result from anorexia, the initiating mechanisms for appetite suppression remain unknown. Here, we tested the hypothesis that DON induces the release of satiety hormones and that this response corresponds to the toxin's anorectic action. Acute intraperitoneal (ip) exposure to DON had no effect on plasma glucagon-like peptide-1, leptin, amylin, pancreatic polypeptide, gastric inhibitory peptide or ghrelin, however, the toxin was found to robustly elevate peptide YY (PYY) and cholecystokinin (CCK) in a dose-dependent fashion. Specifically, ip exposure to DON at 1 and 5 mg/kg bw induced PYY by up to 2.5-fold and CCK by up to 4.1-fold. These responses peaked within 15 to 120 min and lasted up to 120 min (CCK) and 240 min (PPY), corresponding with depressed rates of food intake. Oralingual exposure to DON induced plasma PYY and CCK elevation as well as anorexia comparable to that observed for ip exposure. Direct administration of exogenous PYY or CCK similarly caused reduced food intake. Taken together, these findings suggest that PYY and CCK might be critical mediators of DON-induced anorexia and, ultimately, growth suppression.Toxicological Sciences 08/2012; · 4.48 Impact Factor -
Article: The role of biomarkers in evaluating human health concerns from fungal contaminants in food.
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ABSTRACT: Mycotoxins are toxic secondary metabolites that globally contaminate an estimated 25 % of cereal crops and thus exposure is frequent in many populations. Aflatoxins, fumonisins and deoxynivalenol are amongst those mycotoxins of particular concern from a human health perspective. A number of risks to health are suggested including cancer, growth faltering, immune suppression and neural tube defects; though only the demonstrated role for aflatoxin in the aetiology of liver cancer is widely recognised. The heterogeneous distribution of mycotoxins in food restricts the usefulness of food sampling and intake estimates; instead biomarkers provide better tools for informing epidemiological investigations. Validated exposure biomarkers for aflatoxin (urinary aflatoxin M(1), aflatoxin-N7-guaunine, serum aflatoxin-albumin) were established almost 20 years ago and were critical in confirming aflatoxins as potent liver carcinogens. Validation has included demonstration of assay robustness, intake v. biomarker level, and stability of stored samples. More recently, aflatoxin exposure biomarkers are revealing concerns of growth faltering and immune suppression; importantly, they are being used to assess the effectiveness of intervention strategies. For fumonisins and deoxynivalenol these steps of development and validation have significantly advanced in recent years. Such biomarkers should better inform epidemiological studies and thus improve our understanding of their potential risk to human health.Nutrition Research Reviews 06/2012; 25(1):162-79. · 3.86 Impact Factor
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Lobbyists representing League of Conservation Voters, 2014:
Lobbying Firm Hired | Amount | Subsidiary (Lobbied For) | Lobbyist |
League of Conservation Voters | $175,000 | League of Conservation Voters |
Chieffo, Sara Foote, Madeleine Sittenfeld, Tiernan Taurel, Alex |
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Posts tagged spies-vs-mercs
Spies vs. Mercs evolved in Splinter Cell: Blacklist
Splinter Cell: Blacklist's Spies vs Mercs mode offers a sense of claustrophobic fear that few multiplayer games have been able to offer. It's an asymmetrical assault mode where one team of heavily-armed mercenaries attempts to defend three terminals from nimble spies attempting to hack in and steal...
Splinter Cell: Blacklist resurrects Spies vs. Mercs multiplayer
The iconic asymmetrical multiplayer mode Spies vs. Mercs will return to the Splinter Cell series in Splinter Cell: Blacklist. From the announcement trailer, we can surmise that spies are still dead-set on hacking those terminals, while the mercenaries still have an insatiable bloodlust for sneaky...
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WAP Software
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WBXML Library The WBXML Library is a C library for handling WBXML (Wireless Binary XML) documents. It consists of a WBXML Parser (with a SAX like interface), a generic WBXML Encoder, and an internal representation of the document (WBXMLTree).
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SO WAP! Implementation of the various WAP standards in Erlang. Includes a WAP Gateway, a simple WAP Client (no rendering) and related tools.
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Hambo Java based Multiaccess Device Independent (Mobile, Internet and Broadband) Portal Platform including Applications such as Mail, Calender, Contacts, News, Chat, Ringtones, Icons, SMS applications. All the software are WAP,GSM,PCS,GRPS and 3G Compatible.
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WEBCHECK device status checking over Web WebCheck is a simple device (computer, router, firewall) health status checking or monitoring over HTTP protocol. Very useful to keep track the status of of a multiple servers or workstation from remote location.
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title says it all
circular motion - how to prove/derive v=rw?
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You're moving in a circle of radius r, so the distance you travel in one full trip round the circle is 2.pi.r and you're doing it in one time period, T
speed, v = distance/time = 2.pi.r/T
w = angular speed, and you complete 2 pi radians in time T, so w = 2pi/T
so v=rw -
you can have a little dribble of green tomorrow! (alredy repped today ) -
Heh, thankyou muchly I shall look forward to it
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Bringing power to the people.
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Continental Divide Electric Cooperative is a non-profit, consumer-owned electric distribution co-op providing service to about 23,000 meters throughout Cibola and parts of McKinley, Sandoval, Bernalillo and Valencia counties. CDEC does not own or control any electric generation resources and is an all-requirements purchaser of electric energy from Tri-State Generation and Transmission Association.
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Mars Space Sand 1/2 Ib (Yellow)
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Reflecting those, European stocks were set to fall at opening and another dip in US government bond yields helped support the yen against the dollar. "The market looks to be just chopping around a bit at the moment," said Graham Davidson, a spot currency trader with National Australia Bank in London. "Until we get some more data that make clear whether these concerns about growth are just a blip or a sign of a more concerted slowdown, that's going to be the pattern."
He said the Aussie and South African rand had both benefited from the Chinese numbers, which showed the economy slowing to 7.3 percent annual growth, compared to expectations of 7.2 percent. Industrial output also topped forecast, growing 8.0 percent compared to a forecast 7.5 percent. The Aussie, often seen as a liquid proxy of Chinese growth prospects given Australia's large trade exposure to China, rose 0.2 percent on the day to $0.8804.
Broader risk sentiment still looked wobbly in the wake of this month's market volatility, with Asian shares generally flat on the day and Japan's benchmark Nikkei share average handing back half of Monday's 4 percent rise. Volumes on major currency markets were a fraction of the past month's average. "The absolute China number isn't all that great and the trend has been toward a slower growth rate, so it's probably hard to openly move in the direction of putting risk on," said Koji Fukaya, CEO of FPG Securities in Tokyo.
Weak Japanese equities lent support to the yen, a low-yielding currency that can get a lift from position squaring when investor risk appetites decline. The dollar slid 0.4 percent versus the yen to 106.53 yen. The greenback also edged lower versus a basket of major currencies, with the dollar index easing 0.2 percent to 84.837. The dollar has lost ground in recent weeks as concerns about slowing global growth prompted investors to trim bets that the US Federal Reserve will raise interest rates soon after an expected end in its stimulus later this month. The euro rose 0.2 percent against the dollar to $1.2824. Against the yen, the single currency slipped 0.2 percent to 136.62 yen.
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A treasure of some sorts – Easy everyday gluten-free crêpes
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That was Christmas – Zimtstern à la cannelle
We found a tree, just a few nights before Christmas. A bit of a happy coincidence. Not that we hadn't looked everywhere before. Sold out or cheap plastic. And there it was,… Read More
On rituals and beautiful habits – Biscuits croustillants à la cannelle
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Les biscuits de Noël
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Et un jour en automne – Confiture de châtaignes
[And a day in autumn – Chestnut jam] There is one story. Of the made-up kind. The one I started to tell you – more than – a couple of weeks ago.… Read More
The sound of the forest – Gluten-free chocolate fondant cake
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The gluten-free pastry chef – A story and a vanilla and raspberry baked Alaska
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I'll be left with cinnamon croissants
I guess like all good things, Sundays have to come to an end too. Today was a good Sunday. We went to bed late enough to wake up mid-morning. Crumpets happened. I… Read More
No other day than a Sunday – Clafoutis aux myrtilles, le Paris Pastry Club
[Blueberry clafoutis] The recipes I make don't come in printed words. They come in barely-readable letters that I've written too fast. Felt-tip pen codes, more often than not smudged with water, or… Read More
La rhubarbe
I remember the rhubarb my grand-père used to grow in the garden. It was thick and green; and would be turned into jar-after-jar of compote which my grand-mère always kept in that… Read More
Un peu comme les objets perdus – Le cake au chocolat de grand-mère
[Not unlike lost property – My grand-mother chocolate loaf cake] Last week I told you about… Read More
Oops #4 – Le cake au chocolat
I've been going through my pictures. There is this chocolate loaf cake. And really, it's been haunting me. I made it at my grand-mère's house. Back on the twenty-third of march 2008,… Read More
Maitriser la pâte brisée, pas à pas – Mastering shortcrust pastry, step by step
Pâte brisée [shortcrust pastry] is a staple in every French home. For us, the recipe comes from my grand-mère, and of course, before I came around, it wasn't much of a recipe.… Read More
Where is home? – A lot of rye and a little milk chocolate kind of cookies
That morning, I woke up early and very unusually rested. I think the last time I had felt like this was when I woke up next to him, with his back beautifully… Read More
Bonjour février
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ZACK Linea Wall Mounted Towel Hook
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ZACK Linea Wall Mounted Towel Hook
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