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U.S.denro Steels
U.S.denro Steels Reviews
U.S.denro Steels 1-
"Too much Work "
- Comp & Benefits
- Work/Life Balance
- Senior Management
- Career Opportunities
I have been working at U.S.denro Steels
ProsBenefits are good, pay is good but not worth the amount of time required. There is not enough money to make me give i\up may family life for a job
ConsDoes not allow for family time Work weekends and on call all the time. The balance between family and work is swayed way too heavily towards work
Advice to ManagementAdviceAllow the workers time to have a personal and family life. Way too demanding. You sell your solu to this place
Recommends -
U.S.denro Steels Interviews
Interview Experience
Interview Experience
Getting an Interview
Getting an Interview
Interview Difficulty
- Application Details
I applied through college or university. The process took 2 weeks – interviewed at U.S.denro Steels in October 2011.
Interview DetailsI was called in for an interview after applying for one through the career placement office at my campus. I got the first interview, which was at my campus. A week or so later I got a call to go to their office building for a second interview, and about 4 days later I got a call with a job offer.
For my offer, the pay was about average, but their benefits were comparable to a high ranking union employee.Interview Questions- How important to you is diversity in the workplace? Answer Question
- Name a good and bad decision you have made recently and the reasoning you used to make these decisions. Answer Question
Negotiation DetailsWhen I got the call with the offer, the HR lady I spoke with sounded as if she wanted an answer right then and there, so I asked if there was any time for my to consider it. They gave me exactly one week, so I went for it.Accepted OfferPositive ExperienceEasy Interview
U.S.denro Steels Awards & Accolades
Let us know if we're missing any workplace or industry recognition – Add an award


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Seafood Jazz & Blues FestivalSubmitted by Stephanie (not verified) on Mon, 10/15/2012 - 10:02am.
This was my first time attending and I had a great time. Spent most of the day there on Saturday and it was beautiful. The music was awesome, food was great. I will plan on attending again. I'm very glad Gregg Allman was able to perform, but all of the other bands, including the jazz bands were great too. »
Reply |

subset: commoncrawl


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The Frazier Museum is home to the sword of Josiah Bartlett, a New Hampshire statesman and second signer of the Declaration of independence.
In Rehearsal: Sybil Ludington
Date: October, 4th 2012 12:30 pm - 12:45 pm
The story of the 16-year-old girl whose midnight ride rivaled Paul Revere's.
1st Floor Theater


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Please help a grieving member of the OVW family
Posted on May 2, 2014One of the members of the OVW family has suffered an unexpected tragedy with the loss of their god-child. Please... Read more
Ohio Valley Wrestling
One of the members of the OVW family has suffered an unexpected tragedy with the loss of their god-child. Please... Read more
Timmy Danger talks with Gilbert Corsey about the newest member to Danger, International - Adam Revolver. However, Mohamad Ali Vaez... Read more
After the miscommunication last week, Mohamad Ali Vaez has chosen to settle the misunderstanding with Adam Revolver in a match. Eddie... Read more
Due to unforseen complications issues, OVW regrettably needs to cancel the show in Elizabethtown taking place tonight, April 19, at the... Read more
After a questionable officiating mistake last week, Gilbert Corsey digs into the story with referee Josh Ashcraft about his decision that... Read more
After the way Marcus Anthony retained his OVW Heavyweight Championship, Danny Davis orders Ryan Howe and Marcus Anthony to compete... Read more
With only one show left until the Sunday edition of the SNS on April 6, Timmy Danger promises a statement... Read more
Upset with the childish bickering from Timmy Danger, Danny Davis has set the record straight regarding the Sunday edition of... Read more
Shiloh Jonze has Tony Gunn teaming with him against Mohamad Ali Vaez and Michael Hayes to prove his worth in the Marauders.... Read more
Following last week's confrontation between Jamin Olivencia, Marcus Anthony, and Timmy Danger, OVW Owner Danny Davis makes a rare appearance... Read more
Marcus Anthony and Timmy Danger celebrate the successful title defense against Jamin Olivencia at the March Saturday Night Special. The... Read more
With the Saturday Night Special happening this Saturday, Jamin Olivencia is paid a visit by OVW Heavyweight Champion Marcus Anthony prior to... Read more
Dylan Bostic and his new wingman the Mexicutioner look to continue their hot streak in the ring and their blatant disregard for... Read more
After the challenge last week, the Body Guy gets his match against Melvin Maximus for the Television Championship. After interfering... Read more
Ohio Valley Wrestling is proud to announce that the February 2014 Saturday Night Special (40!) is now available as Video... Read more


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- Filed Under
Increasingly, the video and information people consume exists somewhere in the "cloud" - that nebulous network of remote servers that is quickly becoming part of everyday life.
Now the way people watch cable TV is shifting to this wireless space, too, with Comcast's release of what it says is the world's first cloud-enabled operating system.
The X1 Platform from Xfinity is the company's latest effort to stay current with how people prefer to consume their entertainment, Comcast regional vice president Kirk Dale said, and also a response to the increasing popularity of Internet ...


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Zebra Print Mirror Compacts
Item Number: |
5954 |
Customer Rating: |
Weight: |
0.09 |
Estimated Delivery: |
Tue. 3/10 - Tue. 3/17
Flat Rate Shipping: |
Give the girls a favor to go wild about with these fun and functional zebra print mirror compacts
Fashion has its staples, like the little black dress, strappy sandals and of course, animal print accessories. At Fashioncraft, we always want to be fashionable. After all, it's in our name. So, we took a favor favorite - a heart shaped mirror compact - and took a walk on the wild side by adding a zebra print with a stylish metallic silver twist!
Description and details:
- Each measures 2.25 " x 2.25"
- Heart shaped compact case is made of shiny black finish hard molded plastic, revved-up with a bold sliver striped zebra pattern
- Opens at a side hinge to reveal a dual glass mirror interior with one regular mirror and one magnified for those times when you need a closer look
- A wildly popular choice for Sweet Sixteen celebrations, Quinceañeras, showers and more
- Packaged in a clear box with a metallic silver ribbon wrap and bow and an attached square matching zebra design "For You" tag
Availability: |
In Stock |
This product will be shipped from New York. See below for transit time (in business days) for UPS Ground Service. Transit times do not include order processing time. See shipping info for details.
Total Reviews: |
1 |
Write a review and share your thoughts with other customers. |
Average Rating: |
5 |
Cute and Classy! 5
Stacey (Gosnell, AR), 4/17/2014
"I just think these mirrors are adorable! I purchased these for my daughter's birthday party as a giveaway to the girls instead of the usual junk toys and candy. I thought the price was very reasonable and they each come in their own little box with tag and tie. Would be appropriate for any age. The inside has both regular and magnified mirrors. Just an awesome little gift."
Customers also shopped for these favors...


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Cookies are small text files stored on your computer. They allow us to distinguish you from other users when you visit this site and to provide helpful features such as your recent searches. Cookies themselves do not contain any personal information, and Infotel does not use cookies to collect personal information.
Book online or call +44 (0)1775 843417 at standard rates.
Overlooking Eyre Square, the elegant Hotel Meyrick features the award-winning Oyster Bar & Grill, and free leisure facilities. Its spacious and elegant rooms have free internet, and there is Wi-Fi in public areas. In the centre of Galway, the Hotel Meyrick is just a 1-minute walk from both the train and bus stations. The dock can be reached in around 5 minutes on foot. You can enjoy magnificent views of the city from the hotel's gym, hydrotherapy baths and outdoor Canadian hot tub. Other leisure facilities include a steam room and monsoon showers. Hotel Meyrick also features Fagan's sports bar. Guests can enjoy a range of drinks in relaxed surroundings.


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Shop our Pop-In collab with Topshop and Topman.
Exclusive finds with a new theme each month.
Shop: Pop-In
Our director of creative projects shares what she's into.
Read More
Stay updated with a steady stream of new info.
A soft, slightly sheer sleep tee is designed with a graceful V-neckline and short sleeves.


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China Rentals for events in Laurel MD Maryland
China Rentals near Laurel, MD Free referrals to China Rentals locally near you.
Party Palace Rentals, LLC - Forest Hill, Maryland serving Laurel Party Palace Rentals is the premiere rental company in Maryland. Located in Harford County, our services include 24/7 on call hot line, backyard events, and large corporate events. Exclusive to the party rental industry.
Top Hat Party Design - Huntingtown, Maryland serving Laurel Our staff is upbeat and ready to help make your event a success. Our equipment is clean, in good working condition and delivered on time.
Hire China Rentals Maryland Laurel.
Additional local businesses nearby (additional transportation charges might apply for some of these):
Premier Party Rentals. - Frederick, Maryland serving Laurel At Premier Party Rentals your event is as important to us as it is to you. We listen closely to Clients needs & desires, and do whatever it takes to exceed their expectations. Our experienced and knowledgeable staff has overseen 100's of events from start to finish. Every event detail from concept to completion is given the highest level of attention & service. This is a rule for success that we provide time and time again. We offer everything from Tents, Tables & Chairs to china, Flatware & Fi
Lotus Production Complete Wedding and Event Services - Vienna, Virginia serving Laurel Complete Wedding and Event Services Virginia VA, Maryland MD, Delaware DE and Washington DC Areas. We are committed to save your valuable time, energy and cash Being ingenious, personal, versatile and arranged Providing a swish, worry-free expertise Partnering with you to make sure your wedding and reception replicate your style and temperament
party rental equitment. - manassas, virginia serving Laurel we are a very reliable company. our customer is first priority.
China Rentals for events in Laurel MD Maryland
China Rentals serving Laurel, Maryland
To easily search for more vendors we suggest searching for
China Rentals Laurel
Custom Search
For corporate event requests with over 300 guests or over $5000.00 you can call us at 1-800-232-6874 ext 7 (commercial events only, not non-profit)
Search Yahoo for China Rentals Maryland Laurel
Search BING for China Rentals Maryland Laurel
*all prices shown are approximations. Your exact price will vary based on date, time, quantity, location, and other factors.
Vendors/Talent/Businesses/Entertainers- List your business here
Home: Plan your party or events | Complete party and event planning categories
© 2013 All Time Favorites


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Bilaspur Hotels
33 Bilaspur Hotels List ranked by travellers
Average Rating -
based on 197 Ratings
& 95 Reviews
| Price Range : Rs.
- 5000
India Says Yes Award
Rank 1
Anand Hotel Road, Opp To Shiv Talkies, Bilaspur
"The hotel is located next to Bus Stand. It offer free Wi-Fi and breakfast. Bilaspur being a..." More ›Amita, Raipur, 4 weeks ago |
Rank 2
Agarsen Square, Link Road, Bilaspur
"Receptionist response was good. Excellent hospitality by the hotel. Response on phone calls were..." More ›Patnayak, Delhi, Today |
Rank 3
Vyapar Vihar Road, Bilaspur
"Good hotel, very near to railway station. Hotel have complimentary pick up and drop facility...." More ›Vinod, Mumbai, 2 months ago |
Rank 4
"The location of the hotel was very sceneric, situated adjacent to Alpa River. The hotel was..." More ›Lipika, Lucknow, Sep 2, 2014 |
Rank 5
"We stayed at this hotel for 3 days. The hotel is a new with spacious rooms, free wi fi with good..." More ›Gurdeep, Jabalpur, 3 weeks ago |
Rank 6
Delhi-Chandigarh-Manali Highway, Bilaspur
"As such there is no particular view around but still the staff are genuine, service is good, food..." More ›Mona, Delhi, Jul 25, 2014 |
Rank 7
"I went this hotel to had my dinner with my better half and the quality food service provided by..." More ›Gosh, Mumbai, Oct 15, 2014 |
Rank 8
Near To CMD Chowk, Link Road, Bilaspur
"The rooms and the toilets are very clean and the rooms are spacious. The hotel is situated very..." More ›Komal, Bangalore, Sep 16, 2014 |
Rank 9
Link Road, Opp To Satyam Cinema, Bilaspur
"I booked my room in the hotel directly on my arrival. Hotel was situated in the city. Look wise..." More ›Raju majhi, Jamshedpur, Sep 18, 2014 |
Rank 10
Telephone Exchange Road, Near New Bus Stand
"The trip was excellent and amazing; the rooms were AC and provided pickup and drop facility. The..." More ›Usha, Durgapur, Dec 19, 2013 |
Rank 11
"This is one of the best hotel I have ever stayed in my life. The atmosphere was really nice and..." More ›Vikas, Bhopal, 2 months ago |
Rank 12
Telephone Exchange Road, Near Bus Stand, Bilaspur
"I went to Bilaspur place and stayed in Hotel Grand Amba. I did book it online. Check-in and..." More ›Amit, Kolkata, Aug 5, 2014 |
Rank 13
Near Bus Stand, Bilaspur
"The hotel is in good location, services is also good. Appearance wise, hotel interior is..." More ›R s kanwar, 3 weeks ago |
Rank 14
"I visited this hotel two month ago. When I had to go for business meeting. The hotel service was..." More ›Sourabh, Jul 24, 2014 |
Rank 15
Vyapar Viahr Road, Above Income Tax Office, Bilaspur
"It was very good hotel. No difficulty to reach the hotel. It was near to the market area. Staff..." More ›Peeyush, Aug 14, 2014 |
Rank 16
"The quality of food and drink is great. Hotel Mahua is one of the best hotel of Bilaspur. The..." More ›Raj, Orai, Sep 18, 2014 |
Rank 17
"Location is excellent and reception guys are very good and cooperative. I had been to this place..." More ›Tarak, Agra, Sep 26, 2014 |
Rank 18
"We went to Bilaspur for a bank audit. We stayed at Hotel Ambe Palace for 3 days and 2 nights...." More ›Om, Raipur, Jul 3, 2014 |
Rank 19
"We went there in a group of 20, and we all were college friends and while returning from Manali..." More ›Mayank, Kota, 3 months ago |
Rank 20
"Good Location great having hotel and great food. Nice rooms, service is satisfactory. Rooms are..." More ›Ranjeet, Bangalore, Aug 18, 2014 |
Rank 21
"Hotel shiva internation is quite best hotel of Bilaspur. The activity may be poor but the quality..." More ›Abhay, Sep 18, 2014 |
Rank 22
"Rooms were too small for a double bed room. Also room smelled kind of moisture. The room service..." More ›Jaisingh, Bangalore, May 14, 2014 |
Rank 23
"They made sure we had a very comfortable and homely stay. I had a good hospitality and felt good..." More ›Kumar, Delhi, Aug 8, 2014 |
Rank 24
Rank 25
Rank 26
Rank 27
Rank 28
Rank 29
Rank 30
1 to 30 of 33 results
Hotels in Bilaspur with Tariff Rates
- There are 28 hotels in Bilaspur reviewed by actual travellers. The top rated Bilaspur hotels are East Park Hotel, The Ananda Imperial, Hotel Deep. The most sought after hotels, based on these reviews are Single stay hotels. The lowest available tariff for Bilaspur hotels stands at Rs.300 and highest hotels rate is approximately Rs.4500. The cheapest Bilaspur hotel deals are available at Rs.410. You can search for Bilaspur B&B/Guest house/Hostel/Lodge(15), Bilaspur Hotel
There are different types of hotels in Bilaspur available for families, lovers, kids, friends and specially for newly married couples who are looking for perfect honeymoon destination.Hotels in Bilaspur by Price
There are 26 Budget hotels in Bilaspur which are priced below Rs. 2500. Tariff for hotels in Bilaspur starts from 300. Cheap hotels in Bilaspur may provide basic amenities like a private bedroom, colour TV, Telephone, AC, 24-hour front desk and housekeeping staff on call. These hotels are affordable and value for money.Hotels near Main Attractions in Bilaspur
The most popular attractions in Bilaspur are Ratanpur, Talagaon, Malhar, Achanakmar Wildlife Sanctuary, Laxmi Narayan Mandir.Hotels near Main Transportation Places
There are 6 railway stations in Bilaspur which are Bilaspur Junction railway station, Korba railway station, Champa railway station, Naila railway station, Akaltara railway station, Bilaspur Road railway station. You can find 5 hotels near Bilaspur Junction railway station.


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24 year old man | Geneva, OH, USA | Seeking women 21-23 within 5 miles
My name is Chevin.. I will be 23 June 6th. I like to ride my quad and just have a good time. Doesn't have to be special.!
I'm just a 22 year old man with a full time job. i love to work hard but play harder. I have 2 little boys i would do anything for. As for a match for me... I don't think i'm to picky she just has to have self respect, at least a little class, (not perfect or conceded) she has to be drama free, and she has to love to have a good time and smile and just go places like dinner, bowling, movies etc. I certainly do not want another woman in my life who doesn't want to do anything with her life except blow my money and lay around on my couch and let the kids destroy my house while i'm at work!
Fishing/Hunting , Movies/Videos , Nightclubs/Dancing
Auto racing / Motorcross, Baseball, Basketball, Football, Swimming, VolleyBall
I exercise 1-2 times per week.
I like Dogs, Fish, Horses
My favorite local spot to relax is walking the trails in the woods at the covered bridge in Geneva, but for a good time i go to down town willoughby and once in a while the flats with friends. Not to big on the cove or any other bars at G.O.T.L.
My dirt bike n quad, love pizza, pasta.. i mean i guess all Italian food... After all i am a Gweedo!
My number 1 favorite thing to do def has to be spending time with my 2 little boys. Wish i could have more time with them. i love to just hang out n have fun
Not really a big reader i haven't a book in a long time.. I guess if i had to pick the most recent thing i read it would be this lap top screen, and a news-paper!
Him | What he is looking for | |
Appearance | ||
Height: | 5'11" (180cms) | 5'0" (152cms) to 5'6" (167cms) |
Body type: | About average | Slender, About average, Curvy, Athletic and toned |
Eyes: | Hazel | No preference |
Hair: | Black | No preference |
Lifestyle | ||
Smoke: | Daily | No preference |
Drink: | Social Drinker | No preference |
Occupation: | Labor / Construction | No preference |
Income: | $25,001 to $35,000 | No preference |
Relationship: | Never Married | No preference |
Have kids: | Yes, and they sometimes live at home (2) | No preference |
Wants kids: | Not sure | No preference |
Background | ||
Ethnicity: | White / Caucasian | No preference |
Faith: | I'll tell you later | No preference |
Languages: | English | English |
Education: | High school | No preference |


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Daytrip Trapeze Henley Tank Top
Item #480902210M
- Southwest print solid trim henley
- Self: 100% Rayon. Contrast: 100% Rayon.
- Machine wash cold. Do not bleach. Line dry. Low iron.
- Made in Mexico.
We changed our page. Tell us what you think.
Daytrip Trapeze Henley Tank Top 1 1
Size run small I tried this on today at my local Buckle in a large, it was so tight on me and normally I can wear a medium to a large, I am a 36"C bust and I don't have that flat tummy anymore but this is so weird that I find I can't fit into many of the tops anymore from Buckle. I always check what size the model is wearing which is always a medium and sometimes they have a 33" bust so I get a large or with a 35" bust I get the medium, but this did not fit me anywhere! So sad because I really love the colors and the pattern and material. May 7, 2013
1-1 of 1


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Beautiful view! voted
Hi, Looking through your Gallery I stumbled upon this Picture.
I like it's interesting framing, gets a vote from me.
Greetings from California Ray
VOTED Great photo!
thanks everyone!
GREAT composition!! VOTED
Beautiful view...Excellent photo...Greetings from Serbia...Djordje...
Thank you - Isabel - Djordje for your comment!
Very good Scenery. Greetings from Turkey.


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About the Book
In this captivating New York Times bestseller, beloved author Gregory Maguire returns to the land of Oz and introduces us to Liir, an adolescent boy last seen hiding in the shadows of the castle after Dorothy did in the Witch. Is he really Elphaba's son? He has her broom and her cape—but what of her powers? In an Oz that, since the Wizard's departure, is under new and dangerous management, can Liir keep his head down long enough to grow up?
Critical Praise
"Maguire is full of storytelling brio . . . his Oz is meticulously drawn." —New York Times
"A tale that adroitly mixes drama, humor, and political satire into a well-knit examination of good and evil." —Library Journal
"Maguire has done it again: Son of a Witch is as wicked as they come. . . . Thoroughly entertaining." —Boston Globe
"Maguire's captivating, fully imagined world of horror and wonder illuminates the links between good and evil, retribution and forgiveness." —People
"As fantastical as a novel set in Oz should be." —Entertainment Weekly
For Wicked:"I fell quickly and totally under the spell of this remarkable, wry, and fully realized story." —Wally Lamb, author of She's Come Undone and I Know This Much is True
"An amazing novel." —John Updike
"Save a place on the shelf between Alice and The Hobbitthat spot is well deserved." —Kirkus Reviews
Product Details
- Imprint: HarperCollins e-books
- On Sale: 03/17/2009
- Pages: 464
- List Price: 7.99 USD
- BISAC1: FICTION / General


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There is no size 14 stock. So i would like to know can size 14 woman wear size 12 for this design/cut ?.
London Times Pebble Crepe Dress
This lovely London Times Pebble Crepe Dress features a fold over drape front sheath and center back zipper.
- Details
- Shipping & Returns
- Reviews
This lovely London Times Pebble Crepe Dress features a fold over drape front sheath and center back zipper.- Color options: Royal
- Solid color
- Short sleeve
- Banded waist
- V-neck
- No lining
- Pullover
- Pleated skirt back
- Knotted bodice
The approximate length from the top center back to the hem is 34 inches. The measurement was taken from a size 4.
Measurement Guide
Maggy London sizing guide
- 95-percent polyester/ 5-percent spandex
- Machine washable
- Model: L3606M
Model stands 5'7 tall and has a 34-inch bust, 26.5-inch waist and 36-inch hips. Model is pictured wearing a size 4.
Features | |
Style | Sheath |
Material | Spandex |
Neck Style | Cowl Neck V-Neck |
Dress Length | Mid-Length |
Fabric Care | Machine Wash |
Dimensions | See description |
Materials | See description |
Model Number | L3606M |
Customer Reviews
- Disclosures & Guidelines
- Filter By:
- Most Helpful
- Most Recent
beautiful color and good fit Love the dress, have not worn it yet, but the fit is perfect. I love the color.
Read Morebones31 Nov 29, 2012 - Helpful 0
- Not Helpful 0
- Flag as Inappropriate
Pretty dress but wrong shape for my body. This is a really pretty dress and I loved the color, it was just the wrong shape for my body type. I am 5'4" with a short torso and this dress made me look very bulky around the midsection. It would look better on a taller person with a longer torso.
Read Morepattiathome Nov 14, 2012 - Helpful 0
- Not Helpful 0
- Flag as Inappropriate
Excellent fit and color is awesome! I bought this dress for an engagement photo shoot, it fit really well and was comfortable for the shoot. The color was exactly the same as the picture. I got the small and let me tell you for a person like me who is 5' 1" its hard to find a dress that doesn't need the length altered. Great buy!
Read Morecar2012 Nov 9, 2012 - Helpful 0
- Not Helpful 0
- Flag as Inappropriate
Neat Dress Love this dress! Color is stunning and the cut is very flattering.
Read Morebkk10110 Jul 25, 2012 - Helpful 0
- Not Helpful 0
- Flag as Inappropriate
stunning attended a festival with the dress, the bright color was an eye-catcher and the fit was perfect it enhanced the curves. dress is simple, you can wear it casually or formally depending on what accessories you wear it with. i had it with a jeweled scarf/necklace, it made the outfit stunning.
Read Morebelena Aug 30, 2012 - Helpful 1
- Not Helpful 0
- Flag as Inappropriate
Adorable and Flattering A keeper. I am pretty picky about dresses on my aging body! This dress is very flattering and the color is gorgeous.
Read Morejaninairene Aug 14, 2012 - Helpful 1
- Not Helpful 0
- Flag as Inappropriate
Questions & Answers
For this particular dress, the sizes for a large state it is sized 12-14. So this should not be a problem.
Shopping Guides
How to Dress for a Casual Wedding
When a wedding invitation asks for guests to come in casual dress, the hosts are typically asking you to show up in fancy business attire. For women, that means skipping the elaborate dresses in favor of more relaxed separates or more casual dresses. There are several simple clothing options that allow women to be comfortable yet stylish for an important occasion like a wedding. Here are a few suggestions for finding the perfect outfit.
Tips on Buying Casual Dresses
Whether you're looking for a dress to wear around town or just to the workplace, casual dresses will keep you comfortable and still look polished enough for an evening with friends or a business meeting. Finding flattering casual dresses can be simplified with just a few shopping steps. Read on for tips on buying casual dresses that fit well and look great.
How to Accessorize Casual Dresses
Have you hit a style slump with your casual dresses, or you are just looking for ways to dress them up a bit? Changing your jewelry and accessories adds variety to your wardrobe. With just a few swaps, you can change your style.
How to Dress for a Casual Office
More and more workplaces are relaxing their dress codes, and casual is no longer exclusively for the weekends. Casual doesn't mean that anything goes, however, which can make it hard to determine exactly what you can and can't wear to work. If your office allows employees to dress down, read the following tips about dressing casually at work.
Top 5 Sweater Dresses
You want to stay cozy during chilly seasons, and a stylish sweater dress is a chic way to look great while still keeping warm. With a simple knit sweater dress, classic turtleneck sweater dresses and other casual dresses, you'll be set for the fall, winter and even spring. Read on for the top five sweater dresses.
How To Wear Empire Waist Dresses
Empire waist dresses have a waistline directly under the bust which creates a flowing appearance that is universally flattering. The cut of empire waist dresses is extremely forgiving and hides trouble spots while accentuating the positives of the female physique. An empire waist dress is extremely versatile, and the dress can go from casual to formal with a few simple changes.
Tips on Purchasing Women's Dresses
Whether you're attending a wedding or fancy party or want something simple to wear to work and around town, you need women's dresses for many various occasions. With so many dresses to choose from, including designer dresses, casual dresses and evening dresses, finding the perfect style for your event and everyday wear can be fun. Read on for tips on purchasing women's dresses for many different occasions.
How To Wear a Shirtdress
Shirt dresses are versatile, comfortable and universally flattering. They easily go from casual to office- or date-ready with the addition of some simple accessories and a change of shoes. You'll be able to wear these dresses often, thanks to this versatility. They are not only a fashionable choice; they're also economical.
Best Jewelry to Wear With a Little Black Dress
The little black dress is a standard, but you don't want to be average when you're wearing one. Black cocktail dresses come in many styles, yet the best way to set yourself apart from the sophisticated party crowd is with interesting jewelry. Just like you dress up jeans and T-shirts with gold charm bracelets and chunky beaded necklaces, you can enhance your little black dress with stylish and eye-catching baubles. Consider some of these fabulous pieces the next time you dress up in your best black mini-dress.
Dress for Success - How to Dress for a Job Interview
Job interviews are never easy, and it's true that the first impression is the most important. Your interviewer will likely begin to make assumptions about you the moment you walk in the door. Luckily, you can make the best impression possible by following these tips about how to dress for your interview.
Best Sweater Dress Styles for Your Shape
They're quickly becoming a fashion staple, but finding the right sweater dress for your cool weather wardrobe can be a bit tricky. The cozy knits of these casual dresses tend to hug your shape more than other fabrics might, making it harder to find the right style of sweater dress for your body type. Read the following tips to help you discover the best sweater dress styles for your shape.
How to Buy a Men's Dress Shirt
Whether you are looking for a shirt to wear to the office or just something to dress up your weekend style, this men's dress shirt guide will walk you through the features to look for. Knowing how to buy the right dress shirt for the right occasion will help you achieve the look you're after, no matter how professional or casual. Learn about dress shirts and find the tips you need to polish your own style.
Top 5 Little Black Dress Styles
The little black dress is a timeless classic and wardrobe staple. When all else fails, a little black dress is there to save your look. This favorite has gone through a lot of makeovers in recent years, with plenty of dresses available in both formal and casual styles. With all the options available, it's becoming easier and easier to find the right dress for you. Start by reading about the top five styles.
Tips on Choosing Men's Sportcoats
When it comes to men's fashion, sportcoats have become accepted as both casual and formal wear. If you need to dress up and are unsure how to dress, the following information can help you find a look that is appropriate. Whether you have a meeting, party or date, you can be presentable and find a timeless sportcoat that complements any wardrobe.
Tips on Buying Men's Shirts
Whether you're looking for stylish men's dress shirts for the office or men's polo shirts for a casual weekend with friends, you need shirts that fit you well and also fit your personal style. Read on for tips on buying men's shirts for every occasion.
How To Care For and Iron Dress Pants
Proper care of dress pants can extend wear time and maximize the investment you've made in your clothing. Knowing how to care for and iron both women's dress pants will keep them looking their best and ensure that every pair of pants in your closet is ready to wear at any time. Caring for your dress pants takes only a few extra minutes every day and can reduce the amount of money you spend on repairs or special cleaning.
Best Reasons to Buy Gold Earrings
Gold jewelry has been coveted since the precious metal was first discovered. Ancient cultures all around the world have incorporated gold into their fashion trends, religious ceremonies and burial supplies. Gold jewelry has remained popular into modern times for many reasons, and gold earrings are one of the best ways to wear the shimmery substance. Gold earrings come in many different styles, from gold hoops and dangling chandelier earrings to pretty studs and elegant teardrop earrings. You can wear yellow gold earrings with your favorite black dress or choose white gold earrings for a casual workday. If you still need to be convinced, check out our reasons for buying gold earrings and then test some gold jewelry for yourself.
Top 5 Styles of Blouses
There are many styles and functions of blouses. From career shirts to more casual looks, having a few blouses in your closet gives you plenty of options for your wardrobe. Dress up a blouse with a skirt and heels or go for cool and casual with a blouse and jeans. Read on to learn all about the top five styles of blouses to have in your closet.
How to Dress Your Baby for Bedtime
Dressing your baby for bedtime is more than just a clean diaper and a lullaby. A baby's skin is extremely sensitive to temperature, especially heat. Dressing your baby too warmly is not only uncomfortable for your baby; it can also be dangerous. Did you know that overheating is a major factor of Sudden Infant Death Syndrome (SIDS)? Although the exact cause of SIDS is unknown, it is a fact that keeping a baby's sleep temperature within the proper range can significantly reduces the risk of SIDS. Choose baby clothing that will keep your child safe and comfortable all night long. Follow our tips to help your baby will sleep better.
How to Dress for a Beach Wedding
Beach weddings are usually less formal than indoor events. As a guest, you'll want to dress appropriately for the setting. The time of day, climate, wind, sand, and saltwater can all affect your wardrobe choice for the occasion. These tips will help you pick out the best men's clothing and women's clothing for a beach wedding.
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News: What You Should Know Before Getting a Haircut; 3 Fixes for Dark Circles Plus, the face cream to beat all face creams.
Holiday Hair: How to Fake a French Twist on Short Hair First the faux bob, now the faux French twist.
Going Short? Why You Need to Change Your Hair Color, Too We asked the colorist behind Coco Rocha's copper pixie to steer us toward the most flattering hues for short cuts.
Short Hair Ideas: Pulled Forward Vs. Slicked Back Play up your short haircut with these red carpet styles.
The Makeover Poll: Alicia Keys Gets A Bob Alicia Keys recently cut her hair. What do you think of the new look?


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On Wednesday, the State of Texas presented its first witnesses in a federal court hearing concerning the latest legal challenge to HB 2, the state's omnibus anti-abortion law.
On Monday, U.S. District Court Judge Myron Thompson didn't just block an Alabama admitting privileges requirement. He also made a powerful case for how targeted regulations of abortion providers further stigmatize abortion providers and patients.
The closure leaves the state with just three clinics that provide abortion care.
A new law in South Dakota bans the practice of so-called sex-selection abortion, while in Indiana two new laws went into effect, banning private insurance coverage of abortion care and mandating that abortion providers obtain admitting privileges at a nearby hospital.
The Pennsylvania Department of Health recently asked Planned Parenthood facilities in the state to submit transfer agreement and admitting privileges information, even though the state currently does not require clinics to have admitting privileges at a nearby hospital. A spokesperson said a department employee was acting on his or her own.
A Dallas hospital tried to revoke two doctors' admitting privileges because they provide legal abortion care, but the two parties have now settled out of court.
Oklahoma Gov. Mary Fallin signed a bill into law Wednesday that requires abortion providers to have admitting privileges at a nearby hospital, among other medically unnecessary requirements for clinics in the state.
One bill would ban abortion providers from teaching sex education in public schools, while the other would require women seeking an abortion to receive information written by the state about the alleged mental health risks associated with the procedure.
The road ahead for abortion providers and their allies to not only preserve George Tiller's specialized service, but simply to stay open, is hardly an easy one. But many of those who knew Dr. Tiller as a colleague and friend are no doubt fortified by remembering one of his favorite sayings: "Attitude is everything."
On Thursday, a state judge heard arguments in a case challenging a 2012 law that severely restricts medication abortion and exposes doctors to felony prosecution for failure to comply.


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Page Showing 1-10 of 30 Results
Avg. Customer Rating (Based on 30 Reviews)
Write a Review | Back to Product Page
Modest suit
By Likes to swim from Sandy, Utah on 3/2/2012
Elastic around waist rides up when swimming. Not enough support in inside bra.
not for the pool
By Eleanor from DE on 2/8/2012
The fabric supporting the bra disintegrated aftwer 3x in the pool
good coverage, runs big
By mommyj from minnesota on 8/14/2011
This suit seems like it would have really good coverage. High neck and arms are good with kids tugging at your suit. The 'built in bra' did not have the support I was looking for and the size ran pretty big. I am returning it and think I would almost need 2 sizes smaller than I measured for the proper bust fit, but then I am concerned the waist and hips will be too snug.
Nice Size
By Stephanie from Toledo,Ohio on 2/2/2015
It is good material and what I needed
didn't like it
By JAK from Detroit, MI on 1/22/2015
The top rides up when swimming. The straps are not elastic, so it's tough to get out of the suit. It's just uncomfortable.
not a good one for me
By LLL from Canada on 1/18/2015
too big - did not fit well
Balloon Breast Design
By day1appraisal from Las Vegas, NV on 12/15/2014
I need to alter this top. It is designed for balloon breasts and wide shoulders. I am not small, but the gaping area under the arm's eye on each side and straps that slip off my shoulders are common when I find something that goes around my middle. I do like the Tuffy suits because they hold up in pool water for water aerobics, but I have to wear a sports bra underneath for support. as I am not enough of a seamstress to alter the bra and bring it down to reasonable size. For size - around the middle and elastic at the bottom is true to size. Top: bust and shoulders is way too big. If I was that big across the top, I'd fall over in the pool.
Did not like
By Daby from Crestview, FL on 7/7/2014
The elastic is way too tight.
Fabric feels stiff.
By Susan in Jupiter from Jupiter, FL on 6/11/2014
Fabric feels like plastic. Not enough support in the bra.
Hard to Take Off
By Nancy from Florida on 6/6/2014
Run small for size. Color does not match bottoms. Top very hard to take off, the arm holes are tight, which looks good but does not give you much room to remove.


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Apologies, but no results were found. Perhaps searching will help find a related post.
Every 3 seconds a pet is killed in shelters everywhere. We are the front line response and only hope they might have for survival. We can't win this war alone. They need our help. Won't you help us to help them?


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Heritage Hotel
Heritage Hotel in Manila
Heritage Hotel
Hotel Guest Reviews of the Heritage Hotel
Our hotel ratings and reviews are from real hotel guests. Priceline.com ensures that its reviews are guests-only by proactively sending hotel surveys to customers after they've completed their hotel stays. In the post-stay surveys, priceline.com hotel customers are asked a number of questions about their stay and the hotel. On a scale of 1-10 with 10 being the best, the survey asks guests to rate their overall experience and specifically rate the hotel's cleanliness, staff and location. Priceline.com does not allow site visitors to post unsolicited hotel reviews.January 2, 2015
Family Traveling with Young Children
April 8, 2014
January 25, 2014
Solo Traveler
Accessible to most interesting shops in town, it is very convenient.
January 3, 2014
Family Traveling with Teens
August 23, 2013
Family Traveling with Teens
clean and friendly. best location going to the mall and airports.
June 4, 2013
The food and drink in the frig cost a lot. So don't use it. There are stores close by. And there nice places to eat . The mall of Asia also close by and the hotel has a shuttle that will take there and back . Hotel has a list of time also the hotel had a nice pool.
February 11, 2012
Solo Traveler
I would recommend this hotel for a short stay 1-2 nights,It is reasonably clean and comfortable!The view from my bedroom was a treat. Awesome! Shuttle to airport should be part of the stay, payment is a ripped off, tipping should be discouraged!
April 24, 2011
Solo Traveler
Over priced rip-off for foreigners Do not use their phone. This is a scam against foreigners also rooms were hot and stuffy not a very good air conditioner system would never stay here again.
October 20, 2010
Family Traveling with Young Children
Nice hotel, convenient to airport and Mall of Asia.
September 19, 2010
Business Traveler
(1 - 10 of 10 reviews)


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24 hours of Le Mans is the ultimate race in the motorsport race.
The 20 year-old third generation driver was picked from over 100 applicants to make the final squad of 24 drivers hailing from 17 countries worldwide.
The team will field two Honda Performance Development (HPD) ARX-04b coupe prototypes.
Team SARD-Morand is in the process of selecting their final drivers for Le Mans.
Surprise announcement that veteran ACO official is to step down from role he's held since 2001.
This is an incomplete list of drivers who we know will take part in the 24 Hours of Le Mans.
Onroak Automotive had the lion's share when the official lists of entries for the Le Mans 24 Hours, the FIA World Endurance Championship and the European Le Mans Series were announced yesterday.
Two Corvette C7.Rs for Corvette Racing's 16th straight appearance.
Super GT Champion, Tsugio Matsuda, to race Nissan GT-R LM NISMO at Le Mans 24 Hours.
The team has remained faithful to French constructor Onroak Automotive.
Tom Kristensen appointed as Grand Marshal at Le Mans 24 Hours
The drivers have chosen the Ligier JS P2 for its performance...
Porsche Team Manthey has reshuffled its factory driver lineup in its two Porsche 911 RSR entries in the Sports Car World Endurance Championship WEC and at the 24 Hours of Le Mans.
Here it is, the complete list of teams entered for the greatest sports car spectacle on Earth.
Despite Daytona 24 dramas for both, they get seal of approval for LMP1 debuts.
Motorsport.com understands that SMP will shift their focus away from WEC this year.
Last night Nissan gave its new LM P1 contender a very special launch at the famous Super Bowl.
After many teasers and spy shots, here it is.
Marc Gene previously worked as a driver for the rival Audi team.
What rivals will Audi have to fend off on 14-15 June to defend its crown?
Above is the first official Nissan LMP1 photo.
The ORECA 05 will roll out at the end of February/beginning of March ahead of its competition debut scheduled for Silverstone.
The Thiriet by TDS Racing team is honoured to once again rely on its technical partners...
The car will also be put to the ultimate test at Le Mans in June.
The 2015 Le Mans endurance season will see the introduction of the new category of cars created by the ACO: the LM P3s (Le Mans prototype 3).
The car was testing at COTA and did not escape the camera.
Jean-Eric Vergne is determined to remain one of the world's top racing drivers.
We have our first glimpse of the 2015 Porsche 919 LMP1 hybrid.
Will Stevens has turned his eye to Le Mans in the event his F1 career stumbles at the first hurdle.
We now know the reason why Franck Montagny was unable to compete in the Formula E Putrajaya ePrix.
Scuderia Corsa will have a busy 2015 including TUSC, Le Mans, and PWC.
The FIA Endurance Commission has officially released sporting regulations for the 2015 WEC season.
Autoweek.com reports Ganassi Racing to field Le Mans effort, and two-car TUDOR Championship team.
Audi has announced their official 2015 driver lineup
The 2015 24 Hours of Le Mans will be held on June 13-14.
Wayne Taylor has confirmed to Motorsport.com his team's intention to compete in the iconic event next year.


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To not want a minute by minute account of Kate's pregnancy and little sympathy for her.
(512 Posts)She's rich, she has all the support in the world and will have no cooking, cleaning, vocational work or responsibilities. I really really really do not want to have daily updates on her condition or her pregnancy for the next nine months! It's so typical of everything she stands for that they have already announced she will have to be on rest for the foreseeable future. As opposed to doing what exactly??!
My best friend had HG and lost a stone in 8 days. She went to hospital and was told to pull her herself together as most women had morning sickness. No time off work, no help whatsoever.
Going off at a bit of a tangent, was hg the reason women were prescribed thalidomide back in the sixties?
I had bog standard ms which was tedious, so I can only sympathise. Is the treatment just symptom control? I guess there must be huge reluctance to take any drug that could possibly be managed without during pregnancy.
However, it is pretty damn obvious that the duchess is going to have an easier time than an ordinary mum, one with children already, or was coping as a single mum, or in poverty, even if their condition is otherwise identical. Possibly balanced out by press intrusion?
She does not have a lot of surplus weight to lose though, she is going to become very thin pretty quickly. Do they just hydrate or try to provide nutrition as well?
Hardly a dimwit with a degree from St. Andrews.
Hope she feels better soon - and although I know it won't happen, that she gets some peace to enjoy her pregnancy and new baby.
Yes Pink you're right.
I covet the life of a woman whose every move/outfit/strand of hair is public property and up for scrutiny.
Who is obsessed over by little flag waving saddos who think they know her.
Who is essentially a walking womb with a naice hairdo.
Who has to live by the rules of an outdated world and has no real freedom.
Jealous of her clothing budget. That's about it.
'I do wonder where she will get support from to share how she's feeling.' Lets hope she doesn't see some of the comments on here
She isn't better educated than me.
And if everything I understand about HG is even halfway true, she's not happier than me either.
I do feel sorry for her. Not least because she is bound to have wanted to keep it to herself till after her first scan.
BUNNY, "she is basically a womb with naice hair" you could say that about any wife then. She wants a child herself I'd say. does that make any mother to be a womb? or just a rich famous titled mother /wife
she isn't more educated than me, and I doubt she's happier... and "married better" doesn't mean anything outside Catherine Cookson novels
she is prettier than me though
I can't stand any of them. They're not an irrelevance to me, they're an actively bad thing and I would welcome their immediate removal.
I wouldn't wish hyperemesis or any other kind of bad pregnancy on her. But I don't care any more about her than the woman next door to me who has SPD and is on crutches with 3 boys with ASD and no money. And I find the sycophantic comments about "carrying the heir to the throne" fascinating in a sort of "wow are there still people who worship the sun" way.
I don't really understand the bitterness towards this woman.
She hasn't done anything actually offensive has she?
I have no idea what she is like, never met her, she doesn't appear to do anything wrong and she still seems to rile people.
There isn't enough money in the world that would see me famous, I like money a lot but fame just looks like a royal (see what I did there) PITA.
What do people actually want from her? All she has done is marry the man she (I assume) loves, why is that such a problem?
Like most people I know, I have very little interest in the royals, but I wish them well.
I have a friend that spent 3 pregnancies in hospital with HG, it was a dreadful time for her.
She's definitely prettier than me though!
Wow, OP, bitter much?
I dunno, Morloth. I am as befuddled as you. I have been on these threads talking about HG, because it made me hideously isolated in my experience at the time and it's cathartic to talk to other sufferers. I have immense sympathy for anyone having their pregnancy overshadowed by illness.
I don't give a shiny shit who she is or how much money she has. She's suffering with a horrible condition, under intense media scrutiny AND trying to enjoy her first pregnancy. For that she has my absolute sympathy.
YABU, and really nasty to boot.
See - I think she would get some really good advice on here about things. But she couldn't post. Somehow it would leak out and then what she writes would get out.
How the hell do you live a life where most things you do are scrutinised and you have little privacy? Who do you trust to get support? Who can you just complain or whinge to?
Morloth, good queston, what do people want from her!?
Gosh, some of this is just vile. Poor woman, she feels like shit, is probably terrified, has had to announce her pregnancy much earlier than she might have chosen to, and if all goes well will spend the next 30 weeks with papparazzi waiting for her to throw up left right and centre.
I really hope she gets the best medical treatment (as should any other woman in the same condition) and a bit of peace and quiet.
Well you better get your head around it because it will be in the news everyday.
Shoot me. I like the royal family.
I feel sorry for anyone with HG. Its not normal morning sickness.
Kate is in hospital because HG is a life threatening condition. She is probably on a drip and feeling wretched.
"My best friend had HG and lost a stone in 8 days. She went to hospital and was told to pull her herself together as most women had morning sickness. No time off work, no help whatsoever."
In the politest way possible, I might suggest that your best friend just had normal morning sickness rather than HG. Perhaps the reason the hospital sent her home was that her life was not at risk. People with HG problems with excessive ketones in the blood and they get very underweight. It really is a serious condition. It is not just puking up four times a day.
There is no way that a woman with proper HG would be able to go work.
I had the same thing, and was meant to be a minor witness in court (was outside a cafe when a girl was attacked by her ex). I had moved from Kent to Berkshire (2+ hours by train) and had no car. I couldnt move to pee without having to be violently sick.
I had to get a sicknote from my GP for the court to be satisfied I really couldnt get there.
GP refused to just speak on the phone to me, insisted I come to her which I did while puking the whole way and wobbling.
Anyway, I got there, and after all that she refused to give me a note for the court, told me I was hardly the first to feel "peaky" and went on about how if I associated with nicer people I wouldnt be in court (no idea why she thought that, I was outside waiting for a friend, didnt know who the victim or attacker were, and wasn't the star witness).
Luckily, dsil rang the court and explained, who warned I could get myself arrested, it was up to the presiding Judge, but thankfully he was fine.
So, no, not everyone has the same attention as Kate, but I bet most private patients have that experience. I wish her better as it was awful, and going from a pregnancy with no sickness with dd 11 months before, it was horrific, and marked the beginning of an awful 6 months where ds ended up being born at 28 weeks. I wouldn't wish it on anyone, however their pregnancy developes, or whoever they are.
Cor - when I chat to my dd about what to avoid in BF material, remind me to mention that they must never be in line to the English throne....as that way madness lies....
Morloth i belive it is down to people being jealous of her.
What's not to like?
She is priviliged beyond belief so there is no doubt that every thing will be at her beck and call. "Carrying the heir to the throne". So fucking what!!
It is only by birth that the Windsors are where they are. And all their hangers on.
"She's prettier than you
She's better educated than you
She's married better than you (the fact shes married is a bonus TBH)
She's happier than you"
unless you actually know the person you're directing it to (and if you do I'd advise the purchase of some armoured clothing) that's a very strange post. Better educated is a bit odd in particular - there will be tons of people here much better educated than Kate Middleton.
I don't quite get how she wolfed down roast beef and rice krispie pud a couple of days ago at her old prep. We don't actually know this isn't yet another fading royalty pr stunt.
And yes, I've been there, done that btw. I just find her utterly pointless, 'carrying the heir' or not. Uninteresting and rather rodentine.
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BrightEdge, a startup that offers tools for large companies to manage their search engine rankings, has raised $12.6 million in a Series C round of funding.
The round was led by new investor Intel Capital, with participation from existing backers Battery Ventures, Altos Ventures, and Illuminate Ventures. CEO Jim Yu says that brings BrightEdge's total funding to a little more than $21 million, of which it has only spent $3 million.
read more
Chute, a startup that offers tools for collecting and displaying photos, has raised $7 million in Series A Funding. The round was led by Foundry Group, with participation from existing investors Freestyle Capital and US Venture Part... Read Post
SEO company Conductor has just raised a $20 million Series C. The round was led by Investor Growth Capital, with participation from previous investors FirstMark Capital and Matrix Partners. Conductor's Searchlight product helps comp... Read Post
BrightEdge, a company that offers tools for search engine optimization and content marketing, is announcing that it has raised a big $42.8 million Series D. The round was led by Insight Venture Partners, with participation from exis... Read Post


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Posts tagged Just
Huawei Just Made The Best-Looking Android Wear Watch Yet
The slickest, watch-iest Android Wear device so far made its appearance Sunday yesterday at Mobile World Congress. Made by the Chinese company Huawei and set for a June release in 20 countries around the world, the simply named Huawei Watch (say that 10 times fast) might be Android's best Apple Watch competitor yet.
If, that is, it weren't for one small problem.
Powerful Shortcomings
The Huawei Watch's specifications aren't that different from those of other Android watches. But a few of its features could make a big impact in the watch's overall performance:
- 1.4-inch AMOLED sapphire crystal display with 400 x 400 pixel resolution at 286 ppi
- 4GB of internal storage
- 512MB of RAM
- Qualcomm APQ8026 1.2GHz processor
- Heart rate monitor, 6-axis motion sensor, and barometer
- 300mAh battery
The main difference here lies in the higher resolution screen—which Huawei says makes it the "highest resolution Android Wear watch"—the heart rate monitor, and the 300mAh battery. That's one of the smallest batteries featured in any Android watch so far—and it's paired with some power-hungry features.
For comparison, the Moto 360—which has taken grief for its underwhelming battery life since its release last September—has a slightly larger display, heart rate monitor, and a 300mAh battery (despite a spec sheet that lists 320mAh). The G Watch R has a slightly smaller display, heart rate monitor, and a 410mAh battery.
Style Over Substance
What the Huawei Watch might lack in terms of battery, it could redeem with pure style. A sapphire crystal display means it will resist the scratches that come with everyday wear and tear. There have been more than a few regretful bumps on my Asus ZenWatch as I reach into the fridge to grab the milk, so the Huawei Watch's tougher display could be one of its best features. It doesn't hurt that the Huawei Watch's round design simply looks great, and will come in gold, silver, or black style choices.
There are still a few months between now and the supposed June release window, so maybe Huawei could swap in a more powerful battery. That's not terribly likely, of course.
More important, until we actually try one out, we won't know how well the battery holds up under normal use. I'm hopeful that Huawei manages to squeeze every ounce of efficiency out of this watch. It'd be a shame for something this good looking to go dark just past lunch.
Images courtesy of Huawei; MWC photo by Adriana Lee for ReadWrite
View full post on ReadWrite
Don't Look Now, But Deep Linking Just Got Hot
Suppose the only way to get to this article—yes, the one you're reading—was to first visit readwrite.com and then trust that you could locate it using the site's navigation tools. Odds are good that you'd be somewhere else right now.
Instead, you probably followed a link shared on Twitter, passed along in email or even displayed here on ReadWrite. That "deep link" made it possible for you to zip right to this page, the same way you can visit just about anywhere on the Web with a single click. Deep links make the Web what it is; they're so deeply ingrained in our online understanding that we take them for granted.
At least on the desktop, that is. Mobile is a different story. Most mobile apps live in their own silos, and offer no way to directly access photos, stories, messages and other information to which they control access. Instead of letting you tap through to a relevant page, mobile links generally direct you to the app's own home page—leaving you to search around the app, often in vain, for whatever you're really looking for.
See also: Facebook Still Thinks It Can Make Apps Work More Like The Web
It's a problem that leads to increased user effort and frustration, and mobile app developers consider solving it a high priority. Suddenly, deep links in mobile are a hot topic.
Button Me Up
Right now, Button SDK is the development world's most prominent open source solution to the mobile deep linking problem.
Out of hundreds of thousands of iOS repositories on code storage community GitHub, Button has trended in the top five most popular for weeks. That means a huge number of users are watching it, downloading it, and using it to integrate deep linking into their mobile apps. Recently, Button added ridesharing service Uber as one of those companies.
Chris Maddern, cofounder at Button, said the company built the SDK as a tool for its own app integration needs, but made it open source when they realized so many other developers were experiencing the same problem.
"From app to app, it's all about taking a user's intent and most closely matching it to the user's action," he said. "If I'm looking at an item and want to buy it in an app, why would you throw me on the home screen? I want to land on the item page so I can buy it."
Why We Need Deep Links On Mobile
It's hard to see the impact that deep linking has on our Internet browsing behaviors until it's no longer there. Users expect to be able to tap from link to link between apps as easily as they do in their browsers. Deep linking is the one technology that lets them.
See also: Google Has New Targeted Ads That Encourage You Dive Into Apps
URX is another company that helps marketers implement deep linking. Mike Fyall, the company's head of marketing, told me that until Android and iOS enable HTTP links on their end, mobile apps will need to use deep links to mimic Web browsing.
"Mobile web browsers support HTTP links just fine—it's apps that are the problem," he said. "They aren't built to respond to HTTP links in the same way, so deep links are used to create similar functionality."
URX takes the technology a step further with a type of deep linking it calls URX Links, previously known as omnilinks. Even deep links have their limits, and URX Links prevent a user's app ownership from curbing his or her browsing experience.
"If a user clicks on a deep link but doesn't have the app installed, they will get an error message," said Fyall. "URX Links route users to the right place whether or not the user has the app installed. If the user has the app installed, the deep link is used and the user is taken inside the app. If the user doesn't have the app installed, they are taken to the mobile website."
The Future Of Mobile Deep Linking
Deep linking is becoming a big asset for marketers who want to drive mobile traffic seamlessly from mobile browsers to mobile apps. The next step for URX, Button, and other companies in the deep linking space is to foster deep linking between different apps. For example, if a user makes a table reservation on partner Rezy, Button wants there to be a link within the Rezy app to order an Uber car to the restaurant.
"We want to build a more connected app ecosystem," said Maddern. "To create the fluid world of users moving around on the Web, and a standardized way of moving users between apps."
Right now, the process of deep linking is wildly different between Apple and Google. URX supports both Android and iOS with separate SDKs, and Button supports just iOS for now, (but is working on Android support). Both companies agree that the possibilities for deep linking could change dramatically depending on what Apple and Google do next.
"For the best user experience possible, we will always need to be able to link directly to a specific place in an app," said Fyall. "Deep links will be the answer for the foreseeable future. However, if the industry agreed on a deep linking standard that worked across platforms and operating systems, they would be easier to implement and use."
Photo by Yandle
View full post on ReadWrite
Group Direct Messaging Is Just Twitter's Latest Flip-Flop
Twitter direct messages just got more talkative. Now you can have a private conversation with a group, the social network announced Tuesday.
Until now, Twitter's direct messaging feature has been reserved for conversations between no more than two participants. Now, you can create groups of up to 20 Twitter users at the same time, and they do not have to be following one another to join. Group direct messages will support "text, photos, links, emoji and Tweets," according to Twitter.
The feature is expected to roll out over the next couple of days to all users.
As Twitter has gotten noisier—and while messaging competitors like Snapchat and WhatsApp grew more significant—users have demanded improvements to its lightweight direct messaging feature, the only way to speak privately on the service. But Twitter has shown anything but a steady hand on the issue. Over the past two years it has lurched back and forth between opening up and restricting new features for direct message.
Here's a quick timeline.
October 2013: You Can Receive Direct Messages From People You Don't Follow
Prior to October 2013, two Twitter users had follow one another to exchange direct messages. Then Twitter inserted a new option where users could explicitly opt to receive direct messages from any of their followers, whether they followed them back or not. The Verge speculated the change allowed brands to have better access to consumers.
October 2013: Twitter Removes Link Sharing From Direct Messaging
That same month, Twitter users learned that they were unable to send links inside direct messages. This might have been a side effect of opening up DMs to a wider range of users, since it would have opened the door to spammy link-based advertising.
November 2013: Twitter Direct Messages Get A Makeover
Direct messages got a new look, one similar to iMessages. The feature began suggesting followers with whom users could begin a private conversation. The move was seen as part of a larger overhaul of direct messaging in order to compete with WhatsApp.
November 2013: Twitter Shuts Down Direct Messages From People You Don't Follow
One short month later, Twitter decided fostering conversations between unverified users who don't follow one another was a bad idea. The company does not respond to requests for comments, but reminds reporters it is "constantly experimenting."
December 2013: Direct Messages Allow Private Photo Sharing
In a possible response to Snapchat's visual success, Twitter began allowing people to share photos in privately in direct messages. Simultaneously, Twitter moved the direct messaging icon to a more prominent position on the top navigation bar of the homepage.
May 2014: Twitter Direct Messaging Still Has A Learning Curve
A few months after Twitter's experimentation craze, ReadWrite reporter Selena Larson reflected on several embarrassing direct message mishaps, known colloquially as "DM fails," in which users blasted messages to the world that they incorrectly thought would remain private. In a world where messaging services like Snapchat and WhatsApp were king, Twitter still lacked quality messaging.
November 2014: Tweet And Link Sharing Return To Direct Messaging
One year later, Twitter revived the ability to include links in direct messages. The social network described it as a secondary feature to the much acclaimed tweet sharing function, where users could take tweets from their timeline and share them privately.
January 2015: Group Messaging Supports Up To 20 Participants
Fast forward to the present, where Twitter is doubling down on direct messaging support. Users can share links, tweets, and emojis with up to 20 other users who may or may not be following one another. The feature includes elements Twitter has backtracked on in the past.
The real question is how long it'll stick around before Twitter does its usual about face.
Illustration by Nigel Sussman for ReadWrite
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Just Give Me Coffee No One Gets Hurt Tin Sign 12 X 8 Home/Office Decor
$22.95 (0 Bids) End Date: Friday Jan-23-2015 18:45:00 PST Bid now | Add to watch list |
Apple Supports Charlie Hebdo And Free Speech, Just Not In Its App Store
In what is likely the fastest App Store approval in iOS history, Apple took only one hour to greenlight an app that promotes a free speech campaign for Charlie Hebdo. Of course, Apple would never have approved an actual Charlie Hebdo app had the caustic—even scabrous—French magazine ever submitted one. (Which it apparently considered back in 2010 before learning of Apple's restrictions and telling the company to "get lost.") Like much of Silicon Valley, Apple is far more committed to the idea of free speech than it is to its actual practice.
The "Je suis Charlie!" app supports the Je Suis Charlie free speech campaign and Charlie Hebdo, which lost 10 staffers in a terrorist attack at its Paris office last week. The order to expedite review of "Je suis Charlie!" came courtesy of Apple CEO Tim Cook, 9 to 5 Mac reports. Cook's assistant responded to an email from Nice-Matin, the French news agency that submitted the app, 10 minutes after it was sent.
Free Speech For Me But Not For Thee
No one should begrudge "Je suis Charlie!" its fast-tracking, even though typical app review takes 10 days or longer. Prospective iOS apps connected to tragedy and the support of free speech are rare events, fortunately.
Pulitzer Prize-winning political cartoonist Mark Fiore, for instance—whose own app was famously rejected by Apple in 2009—has no problem with the speedy approval of "Je suis Charlie!" He does, however, see some tension in the fact that Apple fast-tracked an app intended to express support of cartoonists whose work would never have cleared App Store guidelines.
"I'm glad they approved this app so quickly," Fiore told ReadWrite. "What makes my skin crawl is that most of the stuff Charlie Hebdo does, Apple wouldn't approve."
Fiore, whose work is comparatively tame to the majority of Charlie Hebdo's catalog, ran up against Apple's licensing agreement in 2009. At that time, Apple guidelines stated it would reject apps apps which "may be found objectionable, for example, materials that may be considered obscene, pornographic or defamatory."
According to his Apple rejection letter, the offending content on Fiore's app included political cartoons that referenced torture and White House party crashers. It wasn't until Fiore became the first online-only political cartoonist to win the Pulitzer in 2010 that the Apple App Store had a change of heart. In the ultimate Apple mea culpa, then-CEO Steve Jobs reportedly responded to one of the many customer complaint about Fiore's App Store rejection. "This was a mistake that's being fixed," Jobs wrote from his own email account.
In the wake of his Pulitzer win, Fiore said, "I received this Deep Throat-sort of phone call from Apple." The voice the other side of the phone told him, "you might want to reconsider resubmitting this app and give us a call when you do." Which he did.
Speed When It Counts (For Apple)
The speediness with which Fiore's second submission hit the App Store illustrates how quickly a giant company can make things happen once publicity is involved. Fiore made the call to let Apple know. Within two keystrokes Fiore overheard on the phone, his app hit the App Store. "It was pretty much an instantaneous thing," he said.
The bad PR led to an update of Apple's rules, which now allow for political content and lampooning public figures, but still reflect some subjective sensitivity concerning satire. Time reported in 2013 that Apple yanked the iOS game Sweatshop from the App Store. The developer describes as "lighthearted" but also "based upon very present realities that many workers around the world contend with each day."
"It's the idea that a game intended both as educational and intelligently satirical could wind up banned that's dangerous," Time's Matt Peckham wrote.
Apple isn't the only Silicon Valley behemoth to embrace Charlie Hebdo in the abstract. Twitter's French unit displayed a #JeSuisCharlie banner on its Twitter profile, while Facebook CEO Mark Zuckerberg wrote in a tribute post that "different voices—even if they're sometimes offensive—can make the world a better and more interesting place." Both social networks, of course, have a documented history of censorship. It's the price of building a business in countries where free speech is not a priority.
Google, too, is getting headlines for contributing $300,000 toward 1 million copies of Tuesday's Charlie Hebdo edition. But that cash isn't coming from the goodness of Google's heart, or even its couch cushions. It's part of a $70 million fund Google agreed to set up for French publishers two years ago as part of a settlement with the government over advertising loss. "It's good that (Charlie Hebdo) got the money, but it's good PR for Google, too," Fiore says.
As for Apple, Fiore says, "They show their support, 'We're all for free speech!' But would you run these cartoons? Uh, no."
Apple did not return ReadWrite's request for comment.
View full post on ReadWrite
Bing's New Best-Sellers Carousel Helps Readers Find Just The Right Book
Microsoft's search engine now displays carousel of New York Times best-selling books when searching for specific book genres.
The post Bing's New Best-Sellers Carousel Helps Readers Find Just The Right Book appeared first on Search Engine Land.
Please visit Search Engine Land for the full article.
View full post on Search Engine Land: News & Info About SEO, PPC, SEM, Search Engines & Search Marketing
Tool Overview: LinkRisk — Not Just For Detoxing Anymore
Link Week columnist Julie Joyce reviews the LinkRisk tool suite, which has added some useful capabilities you may not be aware of.
The post Tool Overview: LinkRisk — Not Just For Detoxing Anymore appeared first on Search Engine Land.
Please visit Search Engine Land for the full article.
View full post on Search Engine Land: News & Info About SEO, PPC, SEM, Search Engines & Search Marketing
Content Marketing Without Marketing Is Just Content
Content marketing without the actual act of marketing is just creating content – it's simply contributing more noise to the Web. How can you use SEO techniques to market your content?
View full post on Home – SearchEngineWatch
Mobile Search: Not Just on the Go
A new study from Yahoo shows that more and more mobile searches are happening in the home, where PCs or laptops are also available. How can marketers take advantage of this?
View full post on Home – SearchEngineWatch
HBO Go Cord-Cutting Is Coming, Just In Time For 'Game Of Thrones'
You won't need a cable package (or your parent's HBO Go login) to watch the next season of HBO's most popular original series. The cable channel plans to launch its long-anticipated streaming only service in April, according to an internal memo published by Fortune, the same month Game of Thrones returns for its fifth season.
CEO Richard Plepler said in October that HBO is finally ready to take the money of the 10-million broadband-only homes that don't subscribe to cable, but he didn't mention a cost or time frame. Now, because of a memo explaining HBO's decision move to an outside contractor for streaming service, we know to expect the cord cutting in April, though cost is still up in the air. If you remember those HBO Go streaming outages during Game of Thrones and True Detective episodes, or saw the Twitter meltdowns as they were happening, you get a pretty good idea of why.
See also: Why The CBS Strike Against Dish's Auto Hop May Actually Be A Win For Dish
For viewers however, the big news isn't that HBO is likely contracting MLB Advanced, which provides streaming for the WWE Network, according to Fortune. It's that there's a date on the calendar when HBO Go will be free of its cable package. For entertainment junkies, this is the biggest news since earlier this year, when some of HBO's original programing became available through Amazon's streaming service.
Plepler said in October that the stand-alone HBO Go offering will appeal to viewers who aren't interested in the full cable package, or even a TV connection at all. CBS All Access currently offers 6,500 episodes on demand as well as live TV for $6 a month. As viewership on mobile devices increases and Netflix and Amazon continue to produce popular programming, more legacy TV outlets feel the pressure to finally cut the cord.
View full post on ReadWrite


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Film & Tv Archive
Play Doctor Who: Legacy this week for some special surprises from Titan Comics! Or just read this article. That too.
With the cast of the spell in AXIS #7, Marvel Comics might have just erased questions regarding Magneto's relationship to Wanda and Pietro in the M...
Hey, we figured out who SPOILER is! But wait, who is SPOILER then, really?
Yes, Marvel and Sony talked about sharing Spidey for films, but it looks like those talks are over.
Mark Millar and David Gibbon's comic book comes to theaters February 13, 2015 with lots of blood and swear words, as this new red band trailer sugg...
What the heck just happened on Marvel's Agents of S.H.I.E.L.D.? We have all your answers (and questions too) right here.
Marvel'a Agents of S.H.I.E.L.D. has an historic fall finale tonight, so we're liveblogging the East Coast feed.
Frantically Googling those names revealed on Tuesday's mid-season finale. We've got your back.
Here's as complete a list as we could compile for all TV shows on the air or in development based on comic book properties.
The Screen Junkies make an honest trailer of Guardians of the Galaxy, and it's predictably hilarious.
Bill and Ted's Triumphant Return's creative team tells us all about the new series.
There are more than a couple covers for Star Wars #1 - here are all the ones revealed.
Plus Al Pacino in the Marvel Cinematic Universe? Apparently he's taken a meeting.
MAN OF STEEL's David S. Goyer is staying in the El family developing a series set in the past of Superman's home planet.
30,000 Fans of The Walking Dead want the writers of the show to reverse a mid-season finale death, despite acknowledging that it's impossible to do...
It seems like all the movies Momoa is signed on to play Aquaman in are already on the schedule, according to a report.
Plus George Lucas may be the last man on Earth NOT to have seen the STAR WARS: THE FORCE AWAKENS trailer ... yet.
Mark Hamill is all about role reprisal in 2015, returning as the original Trickster on The CW's hit The Flash.
SNL gets in on the Star Wars: The Force Awakens trailer parody game, and Jeremy Irons talks about Alfred's role in the new film.
According to Deadline, the former producer who was to make his directorial debut on the third Star Trek has exited the director's chair.
Star Wars #1 may be selling one million copies in its big "Welcome Home" at Marvel Comics.
The CW is extending the final episode of 2014 of their new superhero hit The Flash, but for what?
The former 'B---- in Apartment 23' joins the MCU has star of Marvel's second DEFENDERS series with Netflix - Marvel's A.K.A. Jessica Jones.
No, not starring Brigette Nielsen. Over an hour of footage from a proposed SHE-HULK fan film.


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Publications (12)51.42 Total impact
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ABSTRACT: Notch activity regulates tumor biology in a context-dependent and complex manner. Notch may act as an oncogene or a tumor-suppressor gene even within the same tumor type. Recently, Notch signaling has been implicated in cellular senescence. Yet, it remains unclear as to how cellular senescence checkpoint functions may interact with Notch-mediated oncogenic and tumor-suppressor activities. Herein, we used genetically engineered human esophageal keratinocytes and esophageal squamous cell carcinoma cells to delineate the functional consequences of Notch activation and inhibition along with pharmacological intervention and RNA interference experiments. When expressed in a tetracycline-inducible manner, the ectopically expressed activated form of Notch1 (ICN1) displayed oncogene-like characteristics inducing cellular senescence corroborated by the induction of G0/G1 cell-cycle arrest, Rb dephosphorylation, flat and enlarged cell morphology and senescence-associated β-galactosidase activity. Notch-induced senescence involves canonical CSL/RBPJ-dependent transcriptional activity and the p16(INK4A)-Rb pathway. Loss of p16(INK4A) or the presence of human papilloma virus (HPV) E6/E7 oncogene products not only prevented ICN1 from inducing senescence but permitted ICN1 to facilitate anchorage-independent colony formation and xenograft tumor growth with increased cell proliferation and reduced squamous-cell differentiation. Moreover, Notch1 appears to mediate replicative senescence as well as transforming growth factor-β-induced cellular senescence in non-transformed cells and that HPV E6/E7 targets Notch1 for inactivation to prevent senescence, revealing a tumor-suppressor attribute of endogenous Notch1. In aggregate, cellular senescence checkpoint functions may influence dichotomous Notch activities in the neoplastic context.Oncogene advance online publication, 16 June 2014; doi:10.1038/onc.2014.169.Oncogene 06/2014; · 8.56 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Insulin-like growth factor binding protein 3 (IGFBP3), a hypoxia-inducible gene, regulates a variety of cellular processes including cell proliferation, senescence, apoptosis and epithelial-mesenchymal transition (EMT). IGFBP3 has been linked to the pathogenesis of cancers. Most previous studies focus upon proapoptotic tumor suppressor activities of IGFBP3. Nevertheless, IGFBP3 is overexpressed in certain cancers including esophageal squamous cell carcinoma (ESCC), one of the most aggressive forms of squamous cell carcinomas (SCCs). The tumor-promoting activities of IGFBP3 remain poorly understood in part due to a lack of understanding as to how the tumor microenvironment may influence IGFBP3 expression and how IGFBP3 may in turn influence heterogeneous intratumoral cell populations. Here, we show that IGFBP3 overexpression is associated with poor postsurgical prognosis in ESCC patients. In xenograft transplantation models with genetically engineered ESCC cells, IGFBP3 contributes to tumor progression with a concurrent induction of a subset of tumor cells showing high expression of CD44 (CD44H), a major cell surface receptor for hyaluronic acid, implicated in invasion, metastasis and drug resistance. Our gain-of-function and loss-of-function experiments reveal that IGFBP3 mediates the induction of intratumoral CD44H cells. IGFBP3 cooperates with hypoxia to mediate the induction of CD44H cells by suppressing reactive oxygen species (ROS) in an insulin-like growth factor-independent fashion. Thus, our study sheds light on the growth stimulatory functions of IGFPB3 in cancer, gaining a novel mechanistic insight into the functional interplay between the tumor microenvironment and IGFBP3.American Journal of Cancer Research 01/2014; 4(1):29-41. · 3.97 Impact Factor -
Dataset: Dr Ito Susuki et al 2011
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ABSTRACT: BACKGROUND: Expression profiles of some microRNAs (miRNAs) were associated with clinicopathological findings in human prostate cancer (PC), but the relative expression of miRNAs among Gleason patterns (GPs) remains unclear. In this study, we investigated the expression of several known microRNAs in each GP of PC. METHODS: Formalin-fixed, paraffin embedded (FFPE) tissue samples were obtained from radical prostatectomy (RP) (patient set 1, n = 43, including (GP 3) n = 22, (GP 4) n = 35, and (GP 5) n = 12) and needle biopsy (patient set 2, n = 10, (GP 4) n = 10). Cancer tissues from each GP and adjacent normal counterparts were separately collected using laser-captured microdissection (LCM). Real-time RT-PCR was performed to determine the relative expression of miRNAs, including miR-31-5p, -34c-5p, -96-5p, -182-5p, -183-5p, -205-5p, -221-3p, and -222-3p, which were currently reported to be involved in PC progression. RESULTS: In radical prostatectomy samples, relative expression of miR-31-5p, miR-34c-5p, and miR-205-5p in any GP was significantly decreased compared to normal counterpart. However, no significant difference was detected among GP 3, GP 4, and GP 5. Meanwhile, in the same GP4, expression of miR-31-5p miR-182-5p, and miR-205-5p in cancer tissues obtained from high grade cancer was significantly higher than those obtained from intermediate grade cancer. Validation study using biopsy samples revealed that the relative expression of miR-182-5p was statistically higher in high grade cancer even in same GP4. CONCLUSIONS: We confirmed the expression of miR-182-5p depended on the cancer grade even in same GP 4. Expression of miRNA associated with Gleason grading system may contribute to more accurate preoperative cancer risk evaluation. Prostate © 2012 Wiley Periodicals, Inc.The Prostate 11/2012; · 3.57 Impact Factor - Cancer Research 06/2012; 72(8 Supplement):70-70. · 9.28 Impact Factor
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ABSTRACT: Insulin-like growth factor binding protein (IGFBP)-3 regulates cell proliferation and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. We have investigated how the hypoxic tumor microenvironment in ESCC fosters the induction of IGFBP3. RNA interference experiments revealed that hypoxia-inducible factor (HIF)-1α, but not HIF-2α, regulates IGFBP3 mRNA induction. By chromatin immunoprecipitation and transfection assays, HIF-1α was found to transactivate IGFBP3 through a novel hypoxia responsive element (HRE) located at 57 kb upstream from the transcription start site. Metabolic labeling experiments demonstrated hypoxia-mediated inhibition of global protein synthesis. 7-Methyl GTP-cap binding assays suggested that hypoxia suppresses cap-dependent translation. Experiments using pharmacological inhibitors for mammalian target of rapamycin (mTOR) suggested that a relatively weak mTOR activity may be sufficient for cap-dependent translation of IGFBP3 under hypoxic conditions. Bicistronic RNA reporter transfection assays did not validate the possibility of an internal ribosome entry site as a potential mechanism for cap-independent translation for IGFBP3 mRNA. Finally, IGFBP3 mRNA was found enriched to the polysomes. In aggregate, our study establishes IGFBP3 as a direct HIF-1α target gene and that polysome enrichment of IGFBP3 mRNA may permit continuous translation under hypoxic conditions.The FASEB Journal 03/2012; 26(6):2620-30. · 5.48 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive forms of squamous cell carcinomas. Common genetic lesions in ESCC include p53 mutations and EGFR overexpression, both of which have been implicated in negative regulation of Notch signaling. In addition, cyclin D1 is overexpressed in ESCC and can be activated via EGFR, Notch and Wnt signaling. To elucidate how these genetic lesions may interact during the development and progression of ESCC, we tested a panel of genetically engineered human esophageal cells (keratinocytes) in organotypic 3D culture (OTC), a form of human tissue engineering. Notch signaling was suppressed in culture and mice by dominant negative Mastermind-like1 (DNMAML1), a genetic pan-Notch inhibitor. DNMAML1 mice were subjected to 4-Nitroquinoline 1-oxide-induced oral-esophageal carcinogenesis. Highly invasive characteristics of primary human ESCC were recapitulated in OTC as well as DNMAML1 mice. In OTC, cyclin D1 overexpression induced squamous hyperplasia. Concurrent EGFR overexpression and mutant p53 resulted in transformation and invasive growth. Interestingly, cell proliferation appeared to be regulated differentially between those committed to squamous-cell differentiation and those invading into the stroma. Invasive cells exhibited Notch-independent activation of cyclin D1 and Wnt signaling. Within the oral-esophageal squamous epithelia, Notch signaling regulated squamous-cell differentiation to maintain epithelial integrity, and thus may act as a tumor suppressor by preventing the development of a tumor-promoting inflammatory microenvironment.American Journal of Cancer Research 01/2012; 2(4):459-75. · 3.97 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Hepatocyte growth factor (HGF) is a multifunctional molecule that acts as mitogen, motogen, and/or morphogen in a variety of cells. MET, a specific receptor tyrosine kinase for HGF, is upregulated in various tumors including squamous cell carcinoma of the human head and neck (HNSCC), but how HGF affects the expression of downstream functional genes has not yet been elucidated in detail. In the present study, we examined the expression of microRNA (miRNA), non-coding small RNA that regulate cell proliferation and functions by interfering with the translation of target mRNA, with or without HGF stimulation in HNSCC cell line HSC3. Among several miRNAs, in which the expression was altered after HGF stimulation, we focused on miR-200c and miR-27b, both of which were drastically downregulated after HGF stimulation. Expression of ZEB1, a target mRNA for miR-200c, was upregulated 3 and 6 h after HGF stimulation, and that of E-cadherin, a downstream molecule of ZEB1, was downregulated 12 h after HGF stimulation. Expression of ST14/matriptase, an enzyme for extracellular matrix (ECM) degradation and HGF activation and a target mRNA for miR-27b, was drastically upregulated in the protein level after HGF stimulation, although it was not statistically altered in the mRNA level. These results suggest that miR-200c and miR-27b downregulated by HGF might play an important role in epithelial-mesenchymal transition mediated by ZEB1/E-cadherin and ECM degradation and HGF autoactivation mediated by ST14/matriptase, respectively. Altered expression of miRNA directly regulated by HGF might contribute enhanced progressive and invasive characteristics of HNSCC by regulating the translation of HGF-induced functional molecules.Cancer Science 09/2011; 102(12):2164-71. · 3.53 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Zinc finger E-box-binding (ZEB) proteins ZEB1 and ZEB2 are transcription factors essential in TGF-β-mediated senescence, epithelial-to-mesenchymal transition (EMT), and cancer stem cell functions. ZEBs are negatively regulated by members of the miR-200 microRNA family, but precisely how tumor cells expressing ZEBs emerge during invasive growth remains unknown. Here, we report that NOTCH3-mediated signaling prevents expansion of a unique subset of ZEB-expressing cells. ZEB expression was associated with the lack of cellular capability of undergoing NOTCH3-mediated squamous differentiation in human esophageal cells. Genetic inhibition of the Notch-mediated transcriptional activity by dominant-negative Mastermind-like 1 (DNMAML1) prevented squamous differentiation and induction of Notch target genes including NOTCH3. Moreover, DNMAML1-enriched EMT-competent cells exhibited robust upregulation of ZEBs, downregulation of the miR-200 family, and enhanced anchorage-independent growth and tumor formation in nude mice. RNA interference experiments suggested the involvement of ZEBs in anchorage-independent colony formation, invasion, and TGF-β-mediated EMT. Invasive growth and impaired squamous differentiation were recapitulated upon Notch inhibition by DNMAML1 in organotypic three-dimensional culture, a form of human tissue engineering. Together, our findings indicate that NOTCH3 is a key factor limiting the expansion of ZEB-expressing cells, providing novel mechanistic insights into the role of Notch signaling in the cell fate regulation and disease progression of esophageal squamous cancers.Cancer Research 09/2011; 71(21):6836-47. · 9.28 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: Mucinous cystic neoplasm (MCN) of the pancreas is characterized by mucin-producing columnar epithelium and an ovarian-type stroma. It occurs almost exclusively in women and is almost always located in the pancreatic body or tail. Here, we report a case of large MCN located in the pancreatic head but not in the body nor tail in a 32-year-old pregnant woman, which was thought to have grown rapidly during pregnancy. It was ruptured at 34 weeks of gestation and the patient was admitted to the emergency department of the University of Fukui Hospital with an acute abdomen. Emergency cesarean section followed by pancreaticoduodenectomy was performed. The tumor consisted of many small cysts lined by a single-layer of mucinous epithelium with papillary growth and partial solid parts showing invasive growth and sarcomatoid changes, indicating mucinous cystic neoplasm with an associated invasive carcinoma (previously referred as mucinous cystadenocarcinoma). Thickened septa revealed ovarian-type stroma strongly positive for α-inhibin and partly positive for progesterone receptor immunohistochemically. We also review and discuss previous reports of MCNs including those with an associated invasive carcinoma in pregnant patients.Pathology International 01/2011; 61(1):28-33. · 1.59 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: MicroRNAs (miRNAs) are non-coding small RNAs that regulate cell proliferation and functions by interfering with the translation of target mRNAs. Altered expression of miRNA is known to induce various human malignancies. We examined the expression of miRNAs in squamous cell carcinoma of human head and neck (HNSCC) and esophagus (ESCC), compared to that in normal squamous epithelia as well as malignancies of other organs. Microarray analysis showed up-regulation of miR-21, miR-16 and miR-30a-5p in HNSCC and ESCC cell lines compared to normal squamous epithelial cell lines, and consistent high expression of miR-205 and let-7a in both normal and malignant squamous epithelial cell lines. Validation study using real-time quantitative RT-PCR in formalin-fixed paraffin-embedded cancer tissues and paired normal epithelia obtained by Laser-captured microdissection revealed that miR-205 showed highest expression in both malignant and benign squamous epithelia, although it was less expressed in cell lines and tissues other than squamous epithelia. MiR-21, which is an oncogenic miRNA in various malignancies, was also up-regulated in HNSCC and ESCC compared to paired normal squamous epithelia. These results suggest that miR-205 might be a specific marker miRNA of both normal and malignant squamous epithelia, while miR-21 might be a putative oncogenic miRNA in HNSCC and ESCC.Oncology Reports 06/2010; 23(6):1625-33. · 2.19 Impact Factor - [Show abstract] [Hide abstract]
ABSTRACT: We report 2 patients showing invasion of aspergillosis into the central nerve system (CNS). Patient 1, an 81-year-old woman, underwent surgery for sphenoidal sinusitis. She developed cerebral infarction with unconsciousness on 12th postoperative day. CSF examination demonstrated pleocytosis with increased protein and aspergillus antigen. She was diagnosed as having invasion of aspergillosis into the CNS, and was treated with voriconazole. Her clinical manifestations and CSF findings markedly improved. However, the effects of voriconazole gradually attenuated and she demonstrated recurrence of the cerebral infarction. After 2 months, she died of systemic aspergillosis and sepsis. Autopsy studies. Severe atherosclerotic changes with calcification were demonstrated in the bilateral carotid and basilar arteries, and many aspergillus were clustered in the vessel walls. Granulomatous inflammatory lesions with aspergillus were also demonstrated in the area surrounding the chiasm. There were no massive infarcts or bleeding in the brain, but multiple small infarcts were present. Patinet 2, a 64-year-old man, showing bilateral visual loss, was receiving treatment with corticosteroids under a diagnosis of optic neuritis. Two weeks later, he developed cerebral infarction. CSF examination showed pleocytosis with increased protein and aspergillus antigen. He was diagnosed as having invasive aspergillosis from the sphenoidal sinusitis into the CNS. He was treated with voriconazole, and unconsciousness and CSF findings improved transiently. However, he developed a recurrence of the brain infarction and pneumonia and finally died 6 months later. Treatment by voriconazole was definitely effective in both patients, but both patients died of recurrent cerebral infarction, possibly due to resistance for voriconazole, or developing multicellular filamentous biofilms. Voriconazole is recommended as the first choice of antifungal agents for aspergillosis. Aspergillus infection is strongly invasive into arterial vessels. It is important to consider the possible occurrence of cerebrovascular disease when treating invasion of aspergillosis into the CNS.Rinsho shinkeigaku = Clinical neurology 08/2009; 49(8):468-73.
Publication Stats
100 | Citations | |
51.42 | Total Impact Points | |
Top Journals
University of Fukui
- Division of Tumor Pathology
Hukui, Fukui, Japan


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Hoaxes Throughout History
Middle Ages
Early Modern
1900s • 1910s • 1920s • 1930s • 1940s • 1950s • 1960s • 1970s • 1980s • 1990s • 21st Century • 2014
1900s • 1910s • 1920s • 1930s • 1940s • 1950s • 1960s • 1970s • 1980s • 1990s • 21st Century • 2014
Featured Topic:
Hoaxes of 2014
Hoaxes of 2014
Plain Layne (and other fake bloggers) —
The big news in the blogosphere last week was the revelation that a blogger named 'Plain Layne' wasn't who she said she was. Of course if you, like me, had never heard of Plain Layne before, then the news didn't mean a whole lot. But the people who thought they knew her seemed genuinely shocked.
Plain Layne wrote about her life, and her life happened to be far more exciting and racy than the lives of most people, which is why she had a fairly large following. Jason Kottke has…
Posted: Tue Jun 22, 2004. Comments (10)
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