text:
At Eastern Washington's football practice Tuesday, the Roos Field scoreboard was lit up with a reminder of just how close the Eagles came to a national championship appearance last season.
Eagles 42, Bearkats 45.
"It's something just to kind of remind you," coach Beau Baldwin said. "We're human. I can give you coach talk and tell you, 'We prepare the same for every game.' And it's not like we're going to prepare any harder or different this game compared to games coming up, but you're going to feel it, and if you're a competitor, you're going to know that they came in and beat you on your home turf.
"I give all the credit to them. They did a great job, and they came in and got us and earned it. But, as a competitor, you want a shot back, so that just reminds you of who ended your season last year."
The Eagles fell behind 35-0 at halftime, but then-redshirt freshman quarterback Vernon Adams' six second-half touchdown passes were nearly enough to pull the historic comeback. Adams still has the newspaper article posted in his locker.
"Payback," Adams said when asked what one word he would use to describe Saturday's matchup. "I can't stop thinking about that game. I try not to think about it early in the season when we played other teams, but it was still in the back of my mind.
"We owe these guys."
Adams played scintillatingly well the first two weeks, but struggled in the final three quarters of a 33-21 loss at Toledo Sept. 14.
"I need to relax, keep up my fundamentals, my techniques, and play my game," Adams said. "Kill them with my feet if I have to, stay in the pocket, do whatever I have to do to lead my team to a win. That's my main goal – get the win on Saturday."
Bowers Stadium in Huntsville, Texas, will be the site of Saturday's showdown, "about two hours" from Katy, Texas, junior wide receiver Cory Mitchell's hometown. "I'm excited," Mitchell said. "Can't wait to get to play in front of my family."
The Bearkats boast an offense with explosiveness comparable to the Eagles, scoring an FCS-high 52.3 points per game. "There's a lot of things we need to do to secure this game," defensive back T.J. Lee III said. "We know we need to be fundamental. We've had two weeks to prep, now all we got to do is go out and play when the time comes."
Baldwin sees his players practicing hard coming off the bye week, and is eager to watch his team play on Saturday with revenge on their minds. "I think our guys are hungry. The combination of sitting around with a bye week – they want to get going again. And coming off a loss, and having another week to have to taste that without getting a chance at redemption."


text:
Moderators: Jenise, David M. Bueker, Robin Garr
Joy Lindholm wrote:Luckily there has been a great national backlash to flavorless meat, and there are many great farmers and ranchers committed to humanely raising heritage (ie. flavorful) breeds of stock animals.
Karen/NoCA wrote:We have a lot of ranches in this area, one is llano seco in Chico about 80 minutes from here. Trouble is, I see their cuts of pork in locally owned markets and they look uneven and very small. I like my pork chops, to be an even thickness, and bone-in center cut being my choice. I think I will email them and see if they do custom cutting. I know their pork is very popular and starting to show up in restaurants.
Users browsing this forum: No registered users and 4 guests

subset: commoncrawl


text:
Budget of the United States Government: War Supplement
This supplement to the Budget of the United States Government was published for fiscal years 1944-1947. This publication contains detailed recommendations of appropriations and other authorizations for the major war agencies and some of the war-related agencies, superseding the preliminary estimates already submitted.
The 1946 issue was digitized by Internet Archive.
1944 to 1947
Department of Commerce
Download this page from:
Download this page in groups:


text:
The wireless remote control provides extensive information to the operator (power level, operating time, service period, errors etc), ensuring total control of the sawing process and excellent freedom of movement at the workplace.
Copyright © 2008-2011 Husqvarna AB (publ). All rights reserved. All prices shown are recommended retail prices.
Find your local Husqvarna dealer using the dealer locator.


text:
- Muhammad Aizat Zainal Alam
- Shah Alam, Selangor
- Malaysia
This conversation is closed.
How would you advise a person who would like to explore the world, yet has no money at all?
Apart from trying to obtain some cash, what would you tell these sort of people who would like to learn new cultures and meet people of various backgrounds yet has no financial means to do so? Would love some creative answers. =)
Showing single comment thread. View the full conversation.
Feb 12 2013: https://www.couchsurfing.org/ There you go :o)
Showing single comment thread. View the full conversation.


text:
If you are travelling within the Schengen Area when you arrive in Denmark, you do not need to go through passport control. However, you must be possession of valid travel documents and it is a good idea to have a passport for security reasons.
If you will remain in transit, you only need to go through security control if you are flying overseas or outside of the Schengen Area before you can board your flight. If you are travelling within the Schengen Area or domestically, you can just proceed directly to the gate.
If you have booked a trip with one or several stopovers, you and your baggage are checked in all the way to the final destination. Consequently, it is not necessary to check in again. If you have booked your tickets independently of each other, please be aware that you and your baggage are not checked in all the way to your final destination. It is accordingly necessary that you pick up your baggage and check in at the terminal for your next flight. You must also give yourself more time at the airport.
Welcome to SAS Lounges. Take the opportunity to work, relax, eat good food or enjoy some music or a film.
Read more about SAS lounges
The Ni'mat Hand and Foot Spa opened at Copenhagen Airport in May 2009. The wellness center combines a relaxing time of pampering with the opportunity to board a flight with manicured hands and feet.
Ni'mat is Asian-inspired, which can be seen and felt in both the treatments and products as well as the facility design, and is open every day from 7am-9pm CET.
Read more about Ni'mat Hand and Foot Spa
Scandinavian Airlines © 2014


text:
213 Hansen Blvd,
North Aurora, IL 60542
Home of the Exclusive Lifetime Warranty!
Looking for an affordable used car in the North Aurora area? Our pre-owned vehicle lot is full of like-new certified and used cars, vans, SUVs, and trucks for you to see today. We will help get your used car loan in North Aurora too.
If a used car in North Aurora doesn't fit your needs, consider a new Outback, Forester, XV Crosstrek, Impreza or Legacy. We have a great selection of models in North Aurora for you to test drive today. Visit us at 213 Hansen Blvd to see our new and used car selection today!
* Although every reasonable effort has been made to ensure the accuracy of the information contained on this site, absolute accuracy cannot be guaranteed. This site, and all information and materials appearing on it, are presented to the user "as is" without warranty of any kind, either express or implied, including but not limited to the implied warranties of merchantability, fitness for a particular purpose, title or non-infringement. All vehicles are subject to prior sale. Price does not include applicable tax, title, and license. Not responsible for typographical errors.


text:
Narrow your search
The Magellan SmartGPS bridges a gap between connected navigation apps and car-friendly GPS hardware with its ability to sync with the cloud and connect to the Web via Wi-Fi and Bluetooth, but its busy interface could use fewer moving parts.
Pricing not available
The London-based streaming-music service isn't happy about being booted from iAd but says that it's "flattering" to be seen as such a threat to Apple's iTunes Radio.
Chinese media point to the iPhone's Frequent Locations, a feature in iOS 7 that provides location-aware information.
Two months after the infamous bug was discovered, more than half of vulnerable servers remain unpatched.
Should it be considered a crime or free speech when a person threatens to kill someone on social media?
Some hotels and restaurants say customers are using the power of sites like TripAdvisor to finagle free benefits.
A report on Barron's looks at BMW's long-term commitment to electric vehicles and suggests it represents a market threat to Tesla Motors.
A teen tweets at American Airlines that she's from Afghanistan, a member of al-Qaeda, and is "gonna do something really big." The airline responds forcefully. The teen is frightened, then arrested.
Beyond losing official support from Microsoft, the 13-year-old OS was developed in a simpler time when today's cyberthreats were far in the future.
Oculus VR founder Palmer Luckey has revealed that the company's staff and their families have been receiving death threats after the Facebook acquisition.


text:
$14 for a Set of 5 Mirror Wall Decals – Shipping Included ($39 Value)
Set of 5 Mirror Wall Decals
- Retail $39.00
- You save 64%
- You Pay $14.00
Expires 1 months from date purchased
Limit 25 per customer. These are light weight mirrors made of acrylic material (not glass). High reflective surface as a mirror, but very light acrylic wall decals. A decal is a heavy duty sticker that can be re-used many times, thanks to the special adhesive on the back. Decals can be installed and removed from a surface dozens of times, without damaging the paint job. Click here for product's return policy. This voucher has no cash value. Cannot be combined with other offers. Total voucher value must be used in 1 order. Shipping Included. Valid for shipping within the continental USA only. Cannot ship to Alaska, Hawaii or Puerto Rico. Product will be shipped automatically to address entered at checkout within 2-4 weeks of purchase. No voucher redemption is necessary.


text:
There's a point in the movie "High Noon" when Gary Cooper says to his deputy, "Don't shove me, Harv. I'm tired of being shoved." I was reminded of that line this week when I received a letter from a radical hedge fund billionaire threatening to launch an attack on me if I didn't accede to his demands by "high noon on Friday." Tom Steyer of California is demanding that I either repudiate my support for the Keystone XL oil pipeline, or secure a commitment from TransCanada that all the oil in the pipeline be kept in the United States — a violation of US treaty obligations.
While most people in Massachusetts are worried about whether they can pay their rent or their student loans next month, out-of-state billionaires like Steyer spend tens of millions — more than most working people will earn in their entire lifetime — telling them how to vote. I think most Americans are tired of being shoved.


text:
Supply & Demand Chain Executive's Buyer's Guide features products, services, SaaS and cloud-based solutions and companies that supply the logistics and supply chain management industries.
refine by type:
Companies are invited to add or update their listing within the SDCExec.com Buyer's Guide! If you are unable to access, please call Elliot Maras at 800-547-7377 x1693.
For advertising information, please call Ted Banach at 920-568-8314.


text:
Five things to watch in the Angels-Royals ALDS
Week 5 NFL Game Watchability Rankings
Prince Amukamara is playing better because of…sex?
Larry Donnell shouldn't have benched Larry Donnell on his
When Hunter met Muhammad
Five NFL dynasties that never were
The anatomy of a collapse: story of the 2014 Oakland Athleti
Phillies players love Nebraska football
Take a gander at the Pelicans' new court
Your Conference Rankings: Week 5
How close are the LA Kings to the "dynasty" label?
The top five dynasties in NFL history
Hassan N'Dam N'Jikam Flummoxes Curtis Stevens Over 12
Dirk Nowitzki singing David Hasselhoff? Yes please!
VIDEO: Brandon Crawford hits grand slam in one-game Wild Car
Barry Trotz wants the Capitals to have a 'Äúgang mentality'Ä
Video: 'Interstellar' looks even better in third trailer
UEFA Champions League Roundup: Matchday 2
Nintendo is bringing Super Smash Brothers to a tailgate near
A-Wade-ing Father Time
End of season post-mortem: Oakland Athletics
PHOTO: FSU's newest basketball commit makes Jameis Winston
Air Force will wear new helmets this weekend
VIDEO: Felipe Melo Escapes Red With This Two Footed Challeng
VIDEO: Ludogorets Takes Lead And Saves Ronaldo PK Early
Five things to watch in the NL Wild Card game
Georgia Tech becomes first to accept Bitcoin as payment at s
The Pirates aim to put Sid Bream's slide in the past
NHL 15 predicts the Los Angeles Kings will win the Cup again
USC will wear a shiny helmet this weekend against Arizona St
Alabama @ Ole Miss tickets are most expensive for Week 6 in
College Football Viewer's Guide: Week Six
Cavs unveil new blue-rimmed court
5 things to watch in the Central Division
Despite Royals playoff win, Ned Yost's mistakes can't be
10 interesting stats from September in the NFL
The 2014 all-disappointment team
Matt Bonner cosplays at comic con
What Can Roger Goodell Learn From Charlie Strong?
Video: The Fistic Fix, Featuring Floyd Mayweather, Gennady G
Royals lost for a short while after the game, according to M
TGS weekly NFL MVP tracker
Five Draft Picks Why the Raiders Won't Make the Playoffs
Jarrod Dyson stole third, and then he danced
GIF: Brad Marchand jumps to hit Matt Donovan
Pound-For-Pound Top 20 Boxers Update, 10/14
Kobe Bryant takes Iggy Azalea over Swaggy P
Maple Leafs will give 200 tickets away every home game
Jason Spezza wants to "get comfortable first" before tal
Chris Bosh heads back to the post
2012 Archives
2011 Archives
2010 Archives
2009 Archives
Tag:julian benneteau
Under Way In Paris
Powered by
Tags for Joomla
Legal Information
Privacy Policy
TennisDiary.com is a Professional Tennis fan web site and is in no way affiliated with the Professional Tennis Assocation, or its Members or Properties. This site is for informational and entertainment purposes only. TennisDiary.com is not an official web site for the Professional Tennis Assocation or its Members.
Copyright © 2009 www.TennisDiary.com - All Rights Reserved -
Trademarks used herein are property of their respective owners.


text:
Emergency Stop Labels
- Item #:
- Sign Reads:
- Emergency Shut-Off / Interruptor De Emergencia
- Sign Type:
- Surface Mount
- Packaging:
- Sold individually
- Availability:
- In Stock
|Enter Quantity
|Adhesive Backed & Rigid Signs
|7 x 10''
|Label: Outdoor Durable Vinyl (Adhesive Backed)
|7 x 10''
|.055 Outdoor Durable Plastic
|7 x 10''
|.040 Coated Rust Free Aluminum
|10 x 14''
|Label: Outdoor Durable Vinyl (Adhesive Backed)
|10 x 14''
|.055 Outdoor Durable Plastic
|10 x 14''
|.040 Coated Rust Free Aluminum
Sign Construction:
- Signs are digital or screen printed with UV inks.
- Adhesive backed vinyl film labels are supplied with round corners only.
- Aluminum and Plastic signs are supplied with rounded corners and 4 mounting holes.
- Hole configuration for safety signs is illustrated below.
- Signs have been designed for the following applications: fence, wall or any flat surface mounting.
- These signs are not recommended for post mounting applications.
- Refer to Parking and Traffic if post mounting signs are needed.
- Post mounting signs require 2 center holes (top & bottom) not 4 corner holes.
- Signs do not have any over lamination.
- Image / Text on signs is printed directly onto the sign material.
Safety Sign Configuration
Click on image to Zoom →
Safety Sign Fonts:
Brimar standard fonts for most of our safety signs are: Arial / Arial Bold / Arial Narrow / Arial Black
For our custom signs, we allow our customers to select from a range of custom fonts.
Click on this link to view an illustration of the Arial Font Family →
What do you need to know about Safety Signs:
Environmental & facility safety signs are usually larger because they are observed at further distances. These signs usually contain lesser amounts of information for visual clarity at a distance. Signs should be placed in a clearly visible location and should be protected from damage and obliteration.
- When safety signs are distinguished by their color code (ANSI Z535.2) they become useful tools to help protect the health and safety of personnel at the workplace.
- Safety signs are a supplement to, and NOT a substitute for, the required protective measures for eliminating or reducing the hazards in the workplace.
- Reading and understanding safety signs displayed on machinery or around your facility will help minimize the possibility of accidents and increase hazard awareness.
Safety Sign Functions & Objectives are:
- The objective of safety signs is to draw attention rapidly and precisely to objects and situations capable of causing specific injuries or accidents.
- To alert or warn personnel about workplace hazards of which they may not be aware of.
- To restrict access to areas that present dangerous conditions.
- To inform people of safety requirements.
- Provide general information and directions.
- Remind employees where PPE equipment must be worn.
- Show where emergency equipment or exits are located.
- Indicate where certain actions are prohibited.
Posting Safety Signs:
- Safety signs in the workplace should be mounted for optimum viewing.
- Signs should be placed in a manner so that they are legible, non-distracting, and non-hazardous in themselves.
- Signs must be conspicuously posted for review by workers or any personnel approaching the hazardous area.
- Posting safety signs in multiple languages will help ensure all of your employees are aware of the hazards that may be present.
- Where practical place signs approximately every 40 feet.
- In fenced areas, sign posting is only required at access points.
- Placing too many sign, too close together should be avoided.
- The quantity and placement of signs will depend on the extent of the hazards or the zone to be covered.
- Whenever possible use safety symbols that are simple and easy to learn andrecognize.
- If safety symbols are being used they must be as simple as possible and should contain only essential details.
Safety Sign Recommended Viewing DistancesANSI Z535-2007 standard uses a ratio of 25 ft of viewing distance per inch of text for Favorable Reading Conditions, and a ratio of 12 ft of viewing distance per inch of text for Unfavorable Reading Conditions. Determining the safe viewing distance of a sign depends upon many factors: lighting, background, type font and visual acuity. Other factors to consider in determining sign size include: the complexity of the message, the reaction time necessary and the angle the sign will be seen from. In many situations it is better to use multiple smaller signs that are strategically positioned than one large sign. Many times letter size may need to be larger than the values shown on the graphic for a variety of reasons:
- To make the sign more noticeable from other information displayed in the area.
- To enable legibility under low light, or other poor viewing conditions.
- To alert persons sooner than the minimum safe viewing distance.
- To convey special importance for portions of the message.
- To improve legibility for persons who have vision problems with small text.
Click on the link to view an illustration of the Recommended Text Sizes →
Click on the link to Open & Print PDF with Recommended Sign Size & Viewing Distances →
Links to Industries and Government Institutions Governing Signs:
Rigid Material: Coated Aluminum (.040):
Description & Attributes
- Rust free aluminum signs usually coated white or yellow on both sides.
- Graphics are digital or screen printed with UV inks.
- Aluminum will not chip, crack or rust.
- Aluminum is one of the most durable material options offered, with excellent resistance to harsh weather conditions.
- Printed image will resist fading and mild chemicals.
- Outdoor Durability: 5 to 7 years
- Service Temp Range: -40°F to 212°F
- Ink Features: Printed with UV Inks
- Printing Process: Digital or Screen
- Over laminate: None
Rigid Material: Treated Polyethylene Plastic (.055", .125"):
Description & Attributes
- Polyethylene is a rust free, chip and crack resistant plastic (in white or yellow) treated for digital and screen printing.
- Graphics are either digital or screen printed UV inks.
- Polyethylene signs are an economical alternative to aluminum signs, without significant compromise on durability.
- Printed image will resist fading and mild chemicals.
- .055 thick plastic is typically used for safety signs up to 20 x 14"
- .125 thick plastic is typically used for parking and traffic signs, sizes range from 12 x 18" to 24 x 24"
- Outdoor Durability: 2 to 4 years
- Material Flexibility: .055" thick bends easily without causing material fractures, could be molded to fit certain surfaces.
- Service Temp Range: -40°F to 180°F
- Ink Features: Printed with UV Inks
- Printing Process: Digital or Screen
- Over laminate: None
Label Material: 3.5 Mil Adhesive Backed Vinyl Film:
Description & Attributes
- 3.5 mil thick flexible vinyl film coated with an aggressive permanent acrylic adhesive.
- Graphics are digital or screen printed with UV inks.
- Vinyl signs are the most economical option available. A favorite material for indoor application.
- Printed image will resist fading and mild chemicals.
- Outdoor Durability: 2 to 4 years
- Material Flexibility: Conform to either curved or flat surfaces
- Service Temp Range: -40°F to 180°F
- Min. Application Temp: 50° F
- Surface Preparation: Clean and Dry
- Ink Features: Printed with UV Inks
- Printing Process: Digital or Screen
- Over laminate: None
- Sign Features: 1/4" Round Corners
Label Translation


text:
The Salt Lake Sanitarian: Medical Adviser to the Saints
What avail the largest gifts of Heaven, When drooping health and spirits go amiss?1
In April 1888 Dr. Milford Bard Shipp and two of his four wives, Drs. Maggie C Shipp and Ellis R. Shipp, founded a monthly maga¬ zine "devoted to the prevention and cure of diseases and injuries, and the promulgation of the laws of health and life."2 The Salt Lake Sani¬ tarian was subtitled "A Monthly Journal of Medicine and Surgery." It survived until January 1891, offering advice on subjects ranging from cholera to "coffeeism" and encouraging its readers to educate themselves regarding "the laws of life and sanitation."3
The Sanitarian began at a time when the field of medicine was in transition. During the early part of the nineteenth century most mem¬ bers of the medical establishment practiced what came to be known as heroic medicine after Oliver Wendell Holmes gave it that label in de¬ rision. It included purging, bleeding, and administering large doses of drugs. Diagnosis was rudimentary, and few effective medicines were available. The practice of medicine required neither a medical degree nor a license.
Given the uncertain state of orthodox medicine, many patients lost confidence in it and turned to a proliferation of medical sects. In the words of one historian:
As medical science searched for better methods and procedures, the public wandered amid an endless list of pathies, the claims of which rivaled the eschatological dreams of the era's religious and political
Dr. Bennion is a professor of journalism and program leader of women's studies at Humboldt State University, Areata, California. A version of this paper was presented at the annual meeting ofthe Mormon History Association, May 1986.
lSalt Lake Sanitarian, July 1888, p. 84. 2Ibid., April 1888, p. 14. » Ibid.


text:
Premier League Darts Tickets
Regardless of how many top sports events you have been to we guarantee you will have never experienced the unique atmosphere of live darts. The chance to see some of the biggest names in the sport, including 16 time World Champion Phil 'The Power' Taylor is simply too good an opportunity to miss. Darts tickets are always popular and as more and more people want the chance to see the action don't miss out on the great opportunity.
Premier League Darts
GuaranteedAll tickets covered by the viagogo guarantee
Your Money Is SafeWe don't pay the seller until you've been to the event
Secure DeliveryDelivered via e-ticket or courier
Events in the United Kingdom
International Events
|Price from
|Date & Time to be Confirmed
|Betway Premier League Darts 2015 3 Arena Dublin, Dublin IE
More about Premier League Darts Tickets
Buy or sell your Premier League Darts tickets at viagogo. You can also sign up for Ticket Alerts above to receive ticket offers for upcoming Premier League Darts events. If you have any questions about using viagogo, visit our Frequently Asked Questions page.
viagogo is your online ticket marketplace for concert tickets, sports tickets and theatre tickets.


text: I don't think Adam from Man vs Food could even eat two of the burgers I put on the grill last night! Anyone can melt some cheese on top and call it good. I prefer my burgers stuffed with cheese mushrooms and hot sauce! I also kicked them up a notch by kneading in garlic salt, Italian & Cajun seasoning rub. Make a top and bottom with your hamburger patty and simply put your favorite cheeses, bacon, mushrooms etc..in the middle and form together. These were huge, so be prepared to grill just a little longer. Mine worked out to be about 8 minutes a side.


text:
Software Map
Tag cloud | Project Tree | Project List
Project tree
Now limiting view to projects in the following categories:
Development Status :: 4 - Beta [Remove This Filter]
License :: OSI Approved :: GNU General Public License (GPL) [Remove This Filter]
Intended Audience > Database Designers
Browse By:
5 projects in result set.
|0. Autograph - Autograph is an xsl file, which is used to convert the XmlToDDL XML file into a graphviz "dot" file, which is then processed into a postscript diagram. You can then convert that into a png or a jpeg or whatever you like.
|Activity Percentile: 28.23
Activity Ranking: 90.00
Registered: 2008-03-07 20:58
|1. userlocks - This project provides compatibility between the legacy userlock contrib module and the newer advisory locks feature. As of PostgreSQL 8.2, userlocks are no longer provided as part of the PostgreSQL distribution due to licensing issues.
Registered: 2006-07-10 19:09
|2. Search swish-e from PostgreSQL - Query swish-e index from PostgreSQL. This allows integration of search results from swish-e index and structured data from PostgreSQL.
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2005-02-20 13:53
|3. Hyper Estraier search for PostgreSQL - This package consists of PostgreSQL C function which calls Hyper Estraier API and returns results in user defined format and trigger which maintains consistency of data in full-text index. It also include helper script to easily create full-text index.
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2005-06-26 19:44
|4. knoda - Knoda is a KDE database-frontend for Firebird, Paradox, Postgresql, MS Access, Mysql, ODBC and SQLite. Besides tables,views and queries knoda comprises forms and reports. It is scriptable via Python.
Registered: 2004-05-20 16:21


text:
Brain, Lung, and Ovarian Cancers Selected to Initiate The Cancer Genome Atlas
The cancers to be studied first in the pilot phase of The Cancer Genome Atlas (TCGA) project will be brain, lung, and ovarian, officials from NCI and the National Human Genome Research Institute (NHGRI) announced on September 13.
The Institutes launched the pilot phase of TCGA in December 2005 to assess the feasibility of systematically identifying the significant genomic changes involved in cancer using contemporary genomic analysis technologies, including resequencing of selected genes. Read more
A Vision of Progress
Now that it is official, let me emphasize once again what a special honor it is to lead the world's preeminent cancer research organization, especially at a time when our opportunities for progress are without precedent.
There is broad agreement among NCI leaders about how best to seize these opportunities. First, we must continue to address NCI's strategic priorities, through appropriately aligned new initiatives. Second, we are committed to striving to maintain the number of competing awards near the level achieved during the period when the NIH budget doubled. In addition, we are firmly committed to funding new investigators and devising incentives that will attract the best minds to a field so vital to the health of our citizens - and to our country's future development in a changing world market.
Sound fiscal planning, especially in today's difficult budgetary environment, will be required to achieve these goals. Read more
Brain, Lung, and Ovarian Cancers Selected to Initiate The Cancer Genome Atlas
The cancers to be studied first in the pilot phase of The Cancer Genome Atlas (TCGA) project will be brain, lung, and ovarian, officials from NCI and the National Human Genome Research Institute (NHGRI) announced on September 13.
The Institutes launched the pilot phase of TCGA in December 2005 to assess the feasibility of systematically identifying the significant genomic changes involved in cancer using contemporary genomic analysis technologies, including resequencing of selected genes.
The selection of brain, lung, and ovarian cancers, which collectively account for more than 210,000 cases annually in the U. S., followed a rigorous assessment of tumor collections that began over a year ago.
"The three cancer types were selected based on specific scientific, technical, and bioethical criteria," said NCI Deputy Director Dr. Anna Barker. "The biospecimen collections representing brain, lung, and ovary met or exceeded these criteria and represent high-mortality diseases that present significant challenges to the cancer research community."
For example, each collection had to exceed a certain number of samples to achieve statistical power; contain a defined percentage of tumor cells; and have matched normal tissue, outcomes data on patients, and appropriate informed patient consent, to name a few of the criteria.
"We were looking for biospecimen sets of the highest possible quality so that we could have confidence in the results," said Dr. Carolyn Compton, director of NCI's Office of Biorepositories and Biospecimen Research.
Three institutions are donating the biospecimens for the TCGA Pilot Project.
The lung cancer samples are from the Lung Cancer Tissue Bank of the Cancer and Leukemia Group B clinical trials group, housed at Brigham and Women's Hospital; the brain cancer samples (glioblastoma multiforme grade 4) are from the University of Texas M.D. Anderson Cancer Center; and the ovarian cancer samples are from the Gynecologic Oncology Group tissue bank at the Children's Hospital of Ohio State University.
The tissue samples will be stored and processed at the TCGA Biospecimen Core Resource (BCR) facility. The International Genomics Consortium, in collaboration with the Translational Genomics Research Institute, of Phoenix, Ariz., will establish and manage the BCR.
When fully operational, the TCGA Pilot Project will have two groups of centers doing different types of genomic analyses on tissue samples provided by the BCR.
The Cancer Genome Characterization Centers, funded by NCI, will identify changes such as chromosomal rearrangements and the presence of extra copies of genes. Genes of interest will then be resequenced at Genome Sequencing Centers, funded by NHGRI.
The information generated by the centers will be integrated and managed by a Principal Bioinformatics Resource (PBR) and made available to researchers over the Internet. Data are expected to be accessible through this TCGA database by mid-2007.
"The variety of data will provide a view of the cancer problem that we have never had before," noted NHGRI Director Dr. Francis Collins.
During the pilot project, tumor samples will be assessed for alterations in DNA expression, gene regulation (including epigenetic changes that alter gene activity but not DNA sequence), gene copy numbers, and other changes. These data, along with patient outcomes and other clinical data, will be accessed through specific portals that are currently being defined.
"The revolutionary aspect of TCGA is the integration of all of these different types of genomic, biologic, and clinical data," said Dr. Barker. "TCGA promises to open up a whole world of cancer genomics that will reach far beyond these three cancers."
A Vision of Progress
There is broad agreement among NCI leaders about how best to seize these opportunities. First, we must continue to address NCI's strategic priorities, through appropriately aligned new initiatives. Second, we are committed to striving to maintain the number of competing awards near the level achieved during the period when the NIH budget doubled. In addition, we are firmly committed to funding new investigators and devising incentives that will attract the best minds to a field so vital to the health of our citizens - and to our country's future development in a changing world market.
Sound fiscal planning, especially in today's difficult budgetary environment, will be required to achieve these goals. It will fall on the leadership of NCI to make difficult decisions among competing priorities. Scientific consensus in this process will be critical. I will rely on the NCI Executive Committee to discuss operational and scientific issues, guide the decision-making process, and help find the necessary resources, through redeployment, to maintain scientific momentum.
As NCI Director, I take it as my responsibility to find new ways to leverage resources. We will continue our collaborations with other NIH Institutes and Centers, nonprofit organizations, and Federal agencies. We will maintain our support of partnerships with academia that have been so successfully developed within each of the Divisions and Centers at NCI. Such programs stretch across the oncology research spectrum and include opportunities in behavioral science, clinical research, epidemiology, genetics, molecular biology, proteomics, and nanotechnology.
One of the biggest scientific challenges we will face as an Institute will be integrating our diverse research, in order to most effectively utilize new knowledge to generate better outcomes for cancer patients. I like to think of three "spaces": a chemical space, in which we develop the capacity to understand and re-engineer molecules; a biologic space that comprehends the genetic defects that comprise this disease, the signal pathways that become abnormal, the tumor stem cells, and the tissue microenvironment; and a translational space that brings new discoveries to the point where targets and markers inform drug development. Integrating these spaces is dependant on technology and technology development, which bring together the physical and biological sciences. Driving this entire continuum will be computational biology, which adds the rigors of applied mathematics and the capacity to manage, analyze, and utilize large databases. Integrating the chemical, biologic, and translational spaces - with informatics as a common thread - will make the process of interventional discovery much faster, and as we make this continuum faster, we will make it less costly.
One element of our research - from which informatics will be inseparable - will be to study how we can improve the delivery of cancer care to patients in the communities where they live. In an era of highly targeted cancer treatments, I believe that access to care could potentially be the greatest determinant of cancer mortality. NCI will work to extend its clinical trials infrastructure and its science into the community. We will research how to bring the best science to patients - with electronic medical records and interconnected informatics systems helping create a national cohort of cancer patients. This cohort will help us address the translational space and will be a significant factor in reducing the cost of drug discovery.
We live in a time of unparalleled scientific opportunity. NCI will face the challenges that come its way, with a clear vision of how to exploit scientific advances and lessen the burden of cancer.
Dr. John E. Niederhuber
Autoimmune Disorders Linked to Elevated Risk of Hodgkin Lymphoma
Personal and family histories of autoimmune conditions are associated with an increased risk of Hodgkin lymphoma (HL), according to study results in the September 20 Journal of the National Cancer Institute.
Dr. Ola Landgren of NCI's Division of Cancer Epidemiology and Genetics and colleagues conducted a population-based case control study using data from the Swedish and Danish Cancer Registries, Swedish Multi-Generational Registry, and Danish Central Population Registry. Researchers identified 7,476 case subjects with a first-time HL diagnosis and matched them to 18,573 control subjects by sex, year of birth (within 5 years), and county of residence. More than 86,000 first-degree relatives of case and control subjects also were identified. Subjects were further linked to the Swedish and Danish Inpatient Registries to collect information on discharge diagnoses and 32 autoimmune conditions. All autoimmune conditions were analyzed both individually and by grouping into categories that incorporated knowledge about similar biologic characteristics of autoimmune conditions.
Individuals with a personal history of specific systemic autoimmune conditions - in particular, rheumatoid arthritis and systemic lupus erythematosus - had a significantly increased risk of HL. The associations of both personal and family histories of sarcoidosis with increased risk of HL suggest shared susceptibility that may be important in HL pathogenesis.
These results have implications for future research. According to Dr. Landgren, "This study provides important clues to the role of immune dysregulation and inflammation in the etiology of HL. Future epidemiological and preclinical studies are needed to explain underlying mechanisms of the observed associations. We need to better understand whether they are due to systemic immune stimulation or inflammation, immune-modulating treatments for autoimmune disorders, shared susceptibility, or a combination of these factors."
NCI Study Details Celecoxib's Proteomic Impact
A new study from NCI researchers has unveiled a host of proteins not previously known to be influenced by the COX-2 inhibitor celecoxib, a drug that has shown significant potential as a chemopreventive agent for colorectal cancer. The study was published in the September 12 Cancer Epidemiology, Biomarkers, and Prevention.
Celecoxib's influence on these proteins was not a by-product of its inhibition of the COX-2 enzyme, lead author Dr. Iqbal Ali and colleagues from NCI's Division of Cancer Prevention reported, because the colorectal cancer cell line in which they studied its effects did not express COX-2.
"Many of these potential molecular targets of celecoxib...are of considerable significance in cancer biology, and celecoxib-mediated upregulation or downregulation of these proteins is generally consistent with the relevance of their known cellular functions to the process of carcinogenesis," they wrote.
Proteins that were modulated by celecoxib included those involved in functions such as cell cycle arrest and cell death, DNA synthesis, molecular "chaperoning," glycolysis (converting glucose into energy), and many others.
Using advanced proteomic profiling technologies, the research team conducted the first-ever effort to globally profile the proteins affected by celecoxib in a cancer cell line. Profiling was performed before celecoxib treatment and then afterward, using two doses of celecoxib - one small and one significantly larger. Although celecoxib had different effects depending on the dose administered, at either dose there was approximately 30 percent overlap in the proteins with altered expression.
"Detailed analysis of the functional role of novel candidate molecular targets identified in this study," Dr. Ali and co-authors concluded, "would extend our understanding of the chemopreventive effects of celecoxib" and can help lead to "more effective chemoprevention."
Chemotherapy Fails to Improve Survival in Rectal Cancer
Advanced rectal cancer patients benefit from radiotherapy before surgery to remove their tumors, but there is no clear consensus on whether chemotherapy should be given before or after that surgery. Results from a large European study published in the September 14 New England Journal of Medicine suggest that fluorouracil chemotherapy will reduce local recurrence regardless of when it is given, but does not have an effect on progression-free and overall survival.
Using those who received only preoperative radiotherapy as a standard, the researchers evaluated three different ways to add fluorouracil chemotherapy to the treatment: before surgery, after surgery, or both. They found no statistically significant survival differences among any of these groups, yet "regardless of timing, chemotherapy provides a significant benefit with respect to local control," said the study's lead author, Dr. Jean-François Bosset, from the University of Franche-Comté in Besançon, France, a member of the EORTC (European Organization for Research and Treatment of Cancer) Radiotherapy Group.
The 1,011 patients were followed for a median of 5.4 years; 17.1 percent of those who received radiotherapy alone before their surgery had local recurrence, compared with 8.6 percent who had some form of chemotherapy. Fluorouracil was shown to facilitate surgery by shrinking rectal tumors and reducing pathology, though local recurrence was still significantly reduced even when the drug was given only after surgery.
The results suggest that "future trials should focus on eradicating micrometastases," said Dr. Bosset, because distant recurrence was found to be three times more likely than local recurrence.
Response to Antiangiogenic Drugs for Kidney Cancer Linked to Mutations
Researchers have identified an association between certain mutations in the Von Hippel-Lindau (VHL) gene and the response to drugs that inhibit the growth of tumor blood vessels (angiogenesis) in patients with metastatic clear cell renal cell carcinoma (cRCC), an aggressive form of kidney cancer.
Antiangiogenic therapies are more effective than traditional treatments for some patients with metastatic cRCC, but physicians need ways to identify responders. Mutations in VHL, a tumor-suppressor gene, could potentially be used to help predict response if the association can be confirmed in larger studies.
In this study, the cancer took longer to progress in patients who took antiangiogenic agents such as bevacizumab (Avastin) and had mutations that severely altered the VHL protein. Twenty-five of 43 tumors had a VHL mutation. The median time to disease progression was 13.7 months for patients with mutations that extensively altered the structure of the VHL protein, compared with 7.4 months for patients with less extensive alterations, and 5.5 months for patients with no VHL mutation.
Mutations in the VHL gene are responsible for half of noninherited cases of cRCC. The mutations result in greater expression of the vascular endothelial growth factor (VEGF) and its receptor. VEGF, a regulator of angiogenesis, is a target of drugs such as bevacizumab.
The researchers concluded that the response to therapies targeting the VEGF pathway in patients with metastatic cRCC may be associated with VHL mutations that extensively alter the structure of the VHL protein. The findings were presented by Dr. Erich Jaeger of the University of California, San Francisco, on September 13 at the first meeting on Molecular Diagnostics in Cancer Therapeutic Development, organized by the American Association for Cancer Research.
Afterbirth No Longer an Afterthought: Cord Blood for Cancer Patients
A gentle smack on the bottom, a quick whisk to the warming table for cleanup, and sighs of relief fill the room. A baby is born. New life has come into the world. But the potential for life doesn't rest only with the infant. In the umbilical cord and placenta, leftover blood capable of regenerating tissue is helping doctors to treat cancer patients.
Months before birth, stem cells travel from the fetal yolk sac to the baby's bone marrow where they are ready to replace red blood cells, immune cells, and platelets after birth. In the fetus, the stem cells circulate until the time of birth. After the umbilical cord is cut, cells remaining in the placenta may be collected and frozen for later use.
Like the stem cells that patients receive in bone marrow transplants, these cord blood stem cells can be injected into another person to repair damage caused by radiation or chemotherapy, migrating to the recipient's bone marrow in a process called engraftment.
"The limits of cord blood have yet to be defined," says Dr. Ron Gress, who heads the Transplantation Therapy Section of the Experimental Transplantation and Immunology Branch in NCI's Center for Cancer Research, "but the field has moved far enough forward that we know cord blood as a source of stem cells for transplantation is a viable treatment possibility."
The immune system attacks transplanted tissues when antigens on the new cells' surfaces are too different from those of native tissue. In turn, transplanted immune cells can attack a recipient's body in a condition known as graft-versus-host-disease (GVHD). This is why finding a matched donor is so important in transplantation.
Less than a third of patients who need bone marrow transplants are able to find an ideal match - a blood relative with the same human leukocyte antigens (HLAs) - in time to have the procedure. The next best option is an unrelated matched donor. For African Americans, Asians, and people from other minority groups, this process is particularly restricted because the pool of donors from similar ethnic backgrounds is so small. But there's data to indicate that cord blood could solve many of these problems.
Unlike bone marrow, cord blood is easy to get and poses no harm to the donor. Cord blood is also almost always free of viruses or bacteria, and appears to be more "recipient friendly" because units only need to match in four out of six HLA categories. In additon, there's lower incidence of GVHD than in bone marrow recipients.
The clinical potential is so great that, after receiving recommendations in a report from the Institute of Medicine, Congress passed legislation to increase the nation's inventory of cord blood for use in transplantation. The first contracts for blood banks to begin implementing the plan will be announced by the Health Resources and Services Administration before the end of this fiscal year.
"Cord blood transplants are already the standard practice in Japan, and in Europe and the U.S., the approach is steadily being adopted," says Dr. John Wagner, a pioneer in the field of cord blood transplantation at the University of Minnesota. "Once we begin receiving reports from the U.S. and Europe that document results similar to ours, I think that use of cord blood will dramatically change for adults as well as children."
Much of Dr. Wagner's results come from studies in adults with leukemia. Beyond showing that cord blood transplants can work, researchers have found that HLA-mismatched cord blood units actually attack the cancer, decreasing the chance of relapse. While HLA-mismatching carries a higher risk of transplant-related mortality, new information suggests that this can be minimized by increasing the number of transplanted cord blood cells. "While survival after HLA-mismatched cord blood parallels that of HLA-matched marrow, we continue to look for ways to make it better," says Dr. Wagner.
Then why aren't cord blood transplants standard practice in the United States today for adults? The principal limiting factor is cell dose - the number of cells given to a patient based on body weight. Cord blood is a rich source of stem cells, but the number of cells in the collection is often small. Adults need at least 25 million nucleated cells per kilogram of weight for successful engraftment, and very few of the cord blood units available today through blood banks meet this criterion. As a result, most of the 8,000 transplants conducted during the past 16 years have been in children, whose body weight is generally lower than that of adults.
To overcome this barrier, researchers are combining two individual cord blood units to increase the number of transplanted cells. "For patients who have received a double cord-blood transplant, we have observed a greater chance of survival compared with single-unit transplants," Dr. Wagner says. "While we expected to see less transplant-related mortality with the higher cell dose, we were surprised to see a markedly lower risk of relapse in patients transplanted with two cord blood units."
Dr. Wagner's team has performed nearly 300 double cord-blood transplants in adults and children so far, with 76 percent mismatched at 2 HLA antigens. The next step is to determine how results compare in patients transplanted with two cord blood units versus HLA-matched marrow.
Beyond testing double cord-blood transplants, Dr. Wagner's group is also looking into cord blood-derived natural killer cells in patients with refractory leukemia, cord blood-derived regulatory T cells to enhance engraftment and reduce GVHD, and injection of cord blood right into the bone marrow space to speed marrow recovery.
By Brittany Moya del Pino
Monoclonal Antibodies for Metastatic Colorectal Cancer
Name of the Trial
Principal Investigators
Why This Trial Is Important
In this trial, patients will receive one of two targeted agents, or a combination of the two, that were recently approved by the U.S. Food and Drug Administration for use with combination chemotherapy in the treatment of metastatic colorectal cancer.
The two targeted agents, bevacizumab (Avastin) and cetuximab (Erbitux), are monoclonal antibodies that seek out and block the activity of different proteins important for tumor cell growth and spread. These proteins, vascular endothelial growth factor (VEGF) and epidermal growth factor receptor (EGFR), respectively, are often found in much greater abundance on cancer cells than on normal cells.
"We want to see if combining these agents along with standard chemotherapy can help these patients live longer and possibly shrink their tumors enough to allow potentially curative surgical treatment," said Dr. Venook.
Who Can Join This Trial
Researchers will enroll 2,300 patients with metastatic colorectal cancer who have not received prior treatment. See the list of eligibility criteria at http://cancer.gov/clinicaltrials/CALGB-C80405. This clinical trial is eligible for special Medicare coverage.
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Following are newly released NCI research funding opportunities:
Solicitation of Assays for High Throughput Screening (HTS) in the Molecular Libraries Screening Centers Network
This is a renewal of PAR-05-060 and will use the R03 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3535. Inquiries: Dr. Ingrid Li - firstname.lastname@example.com
Cancer Education Grants Program
This is a renewal of PAR-05-065 and will use the R25 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3530. Inquiries: Dr. Lester S. Gorelic - email@example.com
Mechanisms, Models, Measurement & Management in Pain Research
This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3531. Inquiries: Dr. Ann O'Mara - email@example.com
Mechanisms, Models, Measurement & Management in Pain Research
This funding opportunity will use the R03 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3532. Inquiries: Dr. Ann O'Mara - email@example.com
Mechanisms, Models, Measurement & Management in Pain Research
This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3533. Inquiries: Dr. Ann O'Mara - email@example.com
Genome-Wide Association Studies in the Genes and Environment Initiative - Genotyping Facilities
This funding opportunity will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3538. Inquiries: Dr. Emily L. Harris - email@example.com
Genome-Wide Association Studies in the Genes and Environment Initiative - Coordinating Center
This funding opportunity will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3539. Inquiries: Dr. Emily L. Harris - email@example.com
Genome-Wide Association Studies in the Genes and Environment Initiative - Study Investigators
This funding opportunity will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3540. Inquiries: Dr. Emily L. Harris - firstname.lastname@example.com
Bioengineering Approaches to Energy Balance and Obesity
This is a renewal of RFA-HL-04-022 and will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3527. Inquiries: Dr. Sharon Ross - email@example.com
Pediatric Phase 1/Pilot Consortium
This is a renewal of RFA-CA-01-015 and will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3537. Inquiries: Dr. Malcolm Smith - email@example.com
Gallahan Appointed Deputy Director of DCB
Prior to his appointment, Dr. Gallahan had been serving as DCB's associate director and chief of its Structural Biology and Molecular Applications Branch. He played a major role in developing and managing NCI's IMAT program, which has led to the development of new technologies for cancer research.Dr. Gallahan trained as a cancer biologist and had a distinguished career as a bench scientist within NCI's intramural program. His postdoctoral training included molecular biology, proteomics, bioinformatics, and cancer biology.
Current, Former NCI Grantees Win Lasker Awards
Dr. Elizabeth Blackburn of the University of California, San Francisco; Dr. Carol Greider of Johns Hopkins University School of Medicine; and Dr. Jack Szostak of Harvard Medical School were recognized for their work in predicting and discovering telomerase, an RNA-containing enzyme that synthesizes the ends of chromosomes, protecting them and maintaining the integrity of the genome. Their work laid the foundation for studies that have connected telomerase and telomeres to human cancer and age-related conditions. Drs. Blackburn and Greider currently hold NCI grants; Dr. Szostak is a former NCI grantee.The awards will be presented on September 29 in New York City. Additional information about the Lasker Awards and the other award winners for 2006 is available at http://www.laskerfoundation.org.
eHealth Conference Focuses on Patient-Centered Care
Dr. Jon Kerner, deputy director for research dissemination and diffusion in NCI's Division of Cancer Control and Population Sciences, summarized a number of trends that are driving the field, including the shift to paperless health records in the electronic domain. Referring to the interface between electronic and interpersonal activities, he said, "We have to realize that at the end of the day, all of the electronic data represent real people and patients."Joining NCI as meeting sponsors were the National Institute on Drug Abuse, the National Library of Medicine, the NIH's Office of Behavioral and Social Sciences Research and Office of Disease Prevention, the Agency for Healthcare Quality and Research, the Office of Disease Prevention and Health Promotion, the American Medical Informatics Association, and the Health e-Technologies Initiative, a national program office of the Robert Wood Johnson Foundation.
Dr. Anna Barker is Deputy Director of NCI and Deputy Director for Advanced Technologies and Strategic Partnerships. Doug Ulman is Chair of the NCI Director's Consumer Liaison Group, Chief Mission Officer of the Lance Armstrong Foundation, and a three-time cancer survivor. They spoke with the NCI Cancer Bulletin aboutThe Cancer Genome Atlas Pilot Project.
Why were these three tumor types chosen?
Dr. Barker: We selected cancer types that were scientifically and technically appropriate to build TCGA and prepare the teams to analyze other tumors in the future. We also needed to locate and qualify existing biospecimen collections that were of high quality and sufficient quantity to meet the needs of the project. To accomplish these complex goals, we developed a rigorous, three-part selection process that allowed us to make the final selections.
Mr. Ulman: I think it's important for cancer patients to know that, while the cancers to be studied by this project come from existing biorepositories, samples to be studied will eventually be prospectively collected in clinical trials. Participating in clinical trials that meet TCGA criteria will be an excellent way to support the expansion of TCGA.
How will studying these cancers help patients with other cancers?
Dr. Barker: This pilot phase has been designed to study a few cancer types that hold the most promise for helping researchers understand how to design and conduct future studies on a wide range of tumors. TCGA will support the development of new technologies aimed at overcoming the current limitations in genomic analysis and bioinformatics technologies. Another goal is to develop data analysis tools that will allow clinicians to use this new molecular information to better understand subtle differences between subtypes of certain cancer, how tumors develop and progress, and why some cancers respond to certain treatments and not others.
Mr. Ulman: By focusing first on the cancers that will be studied in the pilot phase of TCGA, we expect that researchers will begin to understand how genomic changes at the molecular level may impact all types of cancer. These findings will eventually help to find new ways to target therapies and improve outcomes for all cancer patients.
How will TCGA affect diagnosis and treatment of cancer patients?
Dr. Barker: Achieving the long-term goal of TCGA will benefit patients by enabling the discovery and development of the molecular biomarkers needed to develop targeted interventions to stratify patients for clinical trials, monitor patients on therapy, and define and develop new molecular targets. Discoveries in cancer genomics already have helped identify several new treatments that target cancer-related molecules. For example, Gleevec effectively treats chronic myelogenous leukemia, gastrointestinal stromal tumors, and several other cancers. Another product of cancer genomics research, Herceptin, effectively treats about 20 percent of breast cancers that capitalize on a specific genetic anomaly.
Mr. Ulman: Understanding the genetic changes that cause the uncontrolled cell growth that characterizes cancer will enable researchers and clinicians to develop new diagnostic techniques and targeted therapies, leading to improved outcomes for all cancer patients and, eventually, cancer prevention.


text:
Molly's Q & A
Who's your favorite sports team, and why?
Greenbay Because It is Owned and Operated by Fans and they have great standings. I also Love the Cincinnati Bengals. have always been a Bengals fan Hometown Pride!
What's your favorite movie quote?
Never lie, steal, cheat, or drink. But if you must lie, lie in the arms of the one you love. If you must steal, steal away from bad company. If you must cheat, cheat death. And if you must drink, drink in the moments that take your breath away- hitch
What's your favorite video game, and could you kick our butts at it?
Im a nerd Honesty I play call of duty black ops 1 & 2 and Skyrim occasionally. I love to play mma and nfl also. I could kick any ones butt ;)
Piercings/Tattoos (How many? Where?)
i have 3 tattoos. a sun and moon on my back, lilies on my side and forever love on my foot. I have 3 piercings in each ear my nose and belly button are pierced.
What's the most embarrassing song on your iPod?
probably the weird al songs from when i was in like 7th grade lol
What's your best party trick?
I am the best at party games. how ever i love to Host them and make the drinks. im the bomb at triple flavored jello shots :P
What's the most memorable pick-up line you've ever heard?
do you know cpr because you took my breath away.
What's the worst job you've ever had?
honestly i wouldnt say any of my jobs have been bad
What's the most dangerous thing you've ever done?
sky diving or cliff jumping
It's 4AM after a crazy night out – what are we eating?
some sort of pasta
What's the strangest thing in your fridge right now?
chocolate. i cant eat chocolate unless its cold. i would say thats weird
What's the naughtiest thing you've ever done in public?
;) naughtiest thing I've done in public where people have seen would probably naked Chinese fire dirlls
What do you feel sexiest wearing?
form fitting dresses or bathing suit
Tell us a joke.
This is a story about a couple who had been happily married for years. The only friction in their marriage was the husband's habit of farting loudly every morning when he awoke. The noise would wake his wife and the smell would make her eyes water and make her gasp for air. Every morning she would plead with him to stop ripping them off because it was making her sick. He told her he couldn't stop and that it was perfectly natural. She told him to see a doctor. She was concerned that one day he would blow his guts out. The years went by and he continued to rip them out! Then one Thanksgiving morning as she was preparing the turkey for dinner and he was upstairs sound asleep, she looked at the bowl where she had put the turkey innards and neck, gizzard, liver and all the spare parts and a malicious thought came to her. She took the bowl and went upstairs where her husband was sound asleep and, gently pulling back the bed covers, she pulled back the elastic waistband of his underpants and emptied


text:
Is the Guardian Campaign Losing Steam?
Does it matter?
Please note comments are moderated. After being approved your comment will appear below.
I am my pet's "parent." And that sounds goofy enough; "guardian" sounds too New Age and to me. Just PETA silliness.
Submitted by Shannon | February 17 2012 | Permalink
I'm a dog owner. In no way does that minimize the importance of the relationship I have with my dog. The trouble with "guardian" is that it limits our control over our pets. Anyone can accuse me of not training, grooming, feeding, etc. the way they think is 'best' and take my dog away if I'm only a 'guardian.' I'm far better able to protect and be responsible for my pets if I'm their owner.
Submitted by DC | February 17 2012 | Permalink
One of the problems with guardianship is that it means the state owns your dog. This gives third parties a standing in court to sue you if you don't care for your dog. It also means they can sue you if they BELIEVE you don't care for your dog. This is what the animal rights agenda is all about. Spaying and neutering all dogs and cats until there are no more. Until then, controlling who can have a dog or cat and how they can be housed. I know it sounds crazy but Guardianship is the first step toward taking away your ability to defend and keep your dog legally. If you are unsure if this could be true, check out any animal rights abolitionist web site or look up the quotes from Ingrid Newkirk about eliminating domesticated animals. This is not my personal belief but it is widespread and it is what animal "rights" is all about.
Submitted by Anonymous | February 17 2012 | Permalink
I'm also a doggy "mom" - and I refer to my border collie as my son. On his license application I refer to myself as his guardian.
Submitted by Debra | February 23 2012 | Permalink
DC and Shannon are correct. "Guardians," of pets or people, are appointed and can be challenged for pretty much any reason, and subsequently un-appointed (thought that's not the legal term, I'm sure). The best way to protect our pets remains being their legal owners.
Submitted by Maureen - Washi... | February 23 2012 | Permalink
I didn't realize until reading this that this was an actual campaign, and yes, it does seem ridiculously frivolous to me. And incorrect, for reasons already stated by others commenting here.
I own my dogs, and through that legal relationship, I am also their guardian, protecting them (as they sometimes protect me) and caring (as they sometimes care for me) for them. I did not give birth to them and I am not their parent (as in "pet parent"), though I often refer to myself as Momdog it's for their understanding only. As long as they are considered "property" by the state/legal, I will own them.
Owning something does not mean you're enslaving it, though technically that is what we do when we own another sentient being, but that debate could go on forever. They are vulnerable and as we have created them, are unable to care for themselves (loose dogs die). I am their owner first, by law. Then their caretaker, guardian, companion, and, very rarely, their master (mistress). Mostly, though, they master me. And I wouldn't have it any other way.
Submitted by Star | February 23 2012 | Permalink
I think people place too much importance on words... Words, on their own, mean nothing and give nothing. They only mean what the person behind the word intends for it to mean. Whether I'm my dog's owner, guardian, mommy, or whatever else - I love my dog and she is a member of the family. I think the push for recognition in the human's role in providing and protecting their animals is fantastic. I don't think that's done by changing some words around.
I disagree about the importance of words. What is that quote that says that the pen is mightier than the sword?
I don't see how the word "guardian" means that the state owns your dog. Parents are their children's guardian, not their owners. The state does not take away that ownership unless cruelty or neglect is proven (and often not even then).
Things are "owned." My dogs and cat and cats and chickens are not "things." Therefore, I do not own them, like I own my car.
By the way, the state can take away things you own as well--don't pay your property tax, the state can take away your property. Commit a crime, or don't pay you income tax, the state can take away your property for that as well.
Words have huge psychological impact. Resistance to NOT being called the owner of one's dog is proof of that.
Submitted by Anonymous | February 24 2012 | Permalink
terminology may seem frivolous but i am concerned that this is the gateway to a disturbing trend. one where my neighbor dictates whether or not my choices for the care of my dog is adequate. and i don't mean issues that have already been mandated, and rightly so, against dogs being tethered all day or dogs riding in the back of a pick-up. i mean medical decisions. and i refer again to the case where a neighbor questioned a "guardian's" decision to manage her dogs chronic medical issue with pain medication rather than surgery. the dog was removed from the home and subsequently died in municipal-mandated surgery. had he lived he would have been adopted out to someone the local pound deemed a "better" "guardian." this woman, and her vet, decided that medication-management was adequate given the risks. apparently they were right. i oppose anything that gives anyone the right to take a dog - except in clear abuse cases. these dog-rights activists have gone too far. and i am concerned that it all begins with terminology.
Submitted by Lindsay | February 25 2012 | Permalink
Guardian in no way indicates that the state owns your dog. Children who are cared for by "legal guardians" are not "owned" by the state - they are "owned" by the guardian. Being a guardain by definition is a person who guards, protects, or preserves; a person who looks after and is legally responsible for someone who is unable to manage their own affairs. Now since dogs are unable to manage their own affairs (they cannot drive to the store or the vet to provide for themselves) they fall under this category. The wording turns ownership into something with feeling. You can own an object, and it's just that, you don't have to have sentimental attachment to it. Animals are not objects - they are living beings. This makes the letter of the law more tactile, holding owners responsible for caring for their dogs, not like a car that they occassionally wash and park in the garage for safe keeping. Dogs require basics like food, water and shelter, but it's more than that. They require attention and affection. You can't choose to not educate your children, the same standards are now being held for our canine companions, as they should be. All problem behaviors from nuissance barking to aggression, stem from something they experience or a lack of experience. That's what sets them aside from being objects. Objects cam be left alone. Animals can't. Regardless of wording, it's ignorant to assume your dog can only be taken away if you are reffered to as a guardian vs an owner. If you neglect to care for your dog in any aspect of his life, people will question your ability as a care giver. But it doesn't immediately mean the state will step in to remove that animal or bring charges against you.
Submitted by Barbara Saunders | March 12 2012 | Permalink
Dogs don't care what words we use about them. I like the old-fashioned "master." "Master" has a connotation that is positive and responsible: that the person has undertaken a comprehensive learning process to understand and properly handle and train the dog. As much as it might feel icky, a dog does not have agency and is "subject" to the owner. There are also other examples of this. "Master-apprentice" is not considered degrading, and students refer to a senior martial artist as "master."
More From The Bark
More in Guest Posts:
Copyright © 1997-2014 The Bark, Inc. Dog Is My Co-Pilot® is a registered trademark of The Bark, Inc


text:
The Nappy Change Organiser by Munchkin keeps nappies, wipes and accessories organised and handy. It easily attaches to cots, dressers, changing tables walls or doors.
A handy nappy dispenser provides easy access without nappies falling out and a total of 8 convenient storage areas are provided.
Useful info:
- Easily attaches to doors, changing tables, doors or walls
- 8 handy storage areas
- Dimensions: 26x29x8.5 cm
- Nappy dispenser
- Munchkin Nappy Change Organiser
The Travel Booster Seat by Munchkin is a stylish travel bag which transforms easily into a booster seat. There is a convenient and protective storage section for on the go essentials. The Booster seat adjusts to two height positions, is easy to clean and includes a 3-point harness.
This stylish and functional drying rack can be a useful addition to any kitchen. It features little sprouts that can hold up to 12 bottles and accessories and spins for easy access. Brighten up your kitchen with this adorable drying rack.
Munchkin Steam Guard Electric Steriliser
- In Stock
1 review
- Delivery
The Munchkin Steam Guard Rapid Electric Steriliser has been designed to give a large capacity for bottles and other feeding accessories and will form an essential part of you baby equipment. It provides a quick and natural way to destroy bacteria with a fast sterilisation cycle of only 6 minutes. Steam Guard safety reassurance means the steriliser will safely disinfect bottles, soothers, accessories and more.
A heat sensitive handle dispalys a symbol to show if the lid is too hot to touch, and an automatic shut off indiciates that sterlisation is complete. Side latches open upwards which secures lid and prevents accidental opening. Its large capacity holds up to 9 standard ro 6 wide neck bottles and accessories at a time. Compatible with all bottle types.
Munchkin Munchkin Steam Guard Microwave Steriliser
- In Stock
1 review
- Delivery
The power of steam cleaning with the safety of Munchkin. Nothing cleans and sterilizes like steam. And microwave steaming is the most convenient of all. To help prevent burns, our microwave sterilizer has tabs that lock upward to prevent accidental opening and a one-way latch as a reminder to always open the lid away from you. Both the handle and tongs are made of heat resistant material for your safety. With a free Deluxe Bottle Brush included to pre-clean bottles, this is one hot item for superb sterilization! Holds almost any bottle brand and sizes. Fits up to 4 bottles and 2 breast pump shields. This microwave sterilizer is lightweight and compact to fit all standard microwaves.


text:
Weekend Forecast
Summit Hill, PA 18250
Partly cloudy this evening...then becoming mostly cloudy. Lows in the mid 50s. South winds 5 to 10 mph.
Partly sunny. A chance of showers...mainly in the afternoon. Highs in the mid 70s. Southwest winds 5 to 10 mph. Chance of rain 50 percent.
Mostly cloudy. A chance of showers in the evening. Lows in the mid 50s. Southwest winds 5 to 10 mph... Becoming northwest after midnight. Chance of rain 50 percent.
Sunny. Highs in the lower 70s.
Mostly clear. Lows in the lower 50s.
Weather News
Other Top Weather Headlines
Severe Storms Target The Midwest Today
The last weekend of summer will start off a bit stormy across the northern tier thanks to some dangerous…More >
Downpours Raise The Flooding Threat In Texas
Odile's remnant moisture will continue to slowly advance across Texas. This will lead to flash flooding problems through the…More >
T.S. Polo Brings Glancing Blow Of Rain to Baja California
Tropical Storm Polo will have only minor impact on the Baja California this…More >
WeatherBug Featured Content
Green Living
You too can help save our planet and put money back in your wallet. Learn how you can take the first steps to reduce your environmental impact, including driving green, easy ways you can conserve water, and energy saving tips. To learn more and discover the benefits of going green, visit WeatherBug's green living section. More >
Sponsored Content
Be Prepared, Know Before
Get faster alerts and better forecasts from the exclusive neighborhood-level WeatherBug network.Learn More


text:
Making sure to put just the right presents under the tree for kids can be a trick even for Santa. If you're hoping to find out what's hot before you head out to shop we've put together a few suggestions.
Retailers themselves are generally the best judges of what's in. Here are what some of the biggest toy retailers in the area and beyond are saying:
Toys 'R' Us
This retailer has a Top 15 list of toys for boys and girls. Some of its suggestions include:
- Doc McStuffins Time for Your Checkup doll
- Lalaloopsy Silly Hair Star Doll
- Furby
- LeapPad2 Explorer
- Wii U
- Hot Wheels R/C Terrain Twister
To see the full list, visit Toys 'R' Us online.
This store agrees with Toys 'R' Us on a few counts, but has its own suggestions, as well. They include:
- Easy Bake Ultimate Oven
- Disney Bounce Bounce Tigger
- Beyblade Destroyer Dome Set
- LEGO Super Heroes Batwing Battle Over Gotham City
- NERF N-Strike Elite Hail-Fire Blaster
To see the full list of suggestions, visit Target online.
This retailer has an extensive list of hot toys for the holidays. It's also running an online contest where customers can vote for what toy they think is the "hottest" of the season. To see all Walmart's suggestions, visit the store online.
This online retailer has a number of suggestions on its "hot" list. It also includes some suggestions for pre-teens and teens. Just Dance 4 anyone?
To see all of Amazon's hot toy suggestions, visit the store online.
What toys are in demand in your house this season? Share your suggestions in the comments section.


text:
It's tradition. It gives a sense of pride. And when 50,000 people do the Tomahawk Chop at Atlanta Braves games, it can be spectacular.Most people believe that the tradition began in the early 1990's, when Deion Sanders played for the Braves. Legend has it, the chop followed him from Florida State, where he went to college.Now it's part of the Braves identity. At Turner Field, several signs welcome fans to "Choptober.""It's electric. It's amazing. They had it for a game last year where everybody got ones that were lit up with lights and stuff like that," said Devin Bosarge. Fans believe the chant to be haunting to the visiting team. At the very least, they hope it's unnerving."I find it so funny that so many people are jealous of the chop, they hate it. But obviously they hate it, because it dominates games," said one fan.
And just maybe, the chop -- which some fans say is a million times better than any wave or song pumped through another stadium's PA -- actually helps the Braves on the field.
KDFW FOX 4400 N. Griffin StreetDallas, Texas 75202
Main Station Directory:(214) 720-4444News Fax:(214) 720-3263 or (214) 720-3333


text:
Quick Links
Shop All Jewelry
Nameplate necklaces are a must-have, and now you can not only get your name beautifully crafted into a necklace charm, but you can get your sorority letters as a nameplate as well! Eve's Addiction is proud to add the Greek alphabet to our nameplate necklace repertoire, as we offer custom Greek letter nameplate necklaces. Turn a classic initial necklace into a meaningful, custom designed piece that celebrates your sorority. Get your full sorority name or just your sorority letters hand-crafted in sterling silver, gold vermeil, or rose gold vermeil nameplate necklace styles.


text:
Milan is Italy`s window on Europe, its most sophisticated and high-tech metropolis. La Scala, its landmark, is one of Europe's most prestigious opera houses. In addition, it's the site of several world-renowned annual trade fairs. Milan is one of Europe's top shopping cities, with an incredible concentration of sophisticated, high style boutiques - and that's only fitting because Milan is the dynamo of the Italian fashion industry. Dolce & Gabbana, Ferrķ, Krizia, Moschino, Prada, Armani, and Versace have all catapulted to international stardom from design studios based here. Inevitably, shopping is of almost religious significance.
Recommended Stay: 2 nights
Must See`s:
The Last Supper by Michelangelo, The Duomo, Pinacoteca di Brera, Quadrilatero d'Oro, Galleria Vittorio Emanuele II, Scala museum and theatre, Piazza Fontana. Arco della Pace, the churches of Santa Maria delle Grazie and San Lorenzo, Corso Venezia and Piazza San Babila and Sforzesco Castle.


text:
FOX 32's Darlene Hill has exclusively learned that the two suspects arrested in the shooting death of 15-year-old Hadiya Pendleton are the alleged gunman and driver, and police say the gunman has confessed.
Chicago police zeroed in on the persons of interest thanks to a tip. The two men, believed to be 18 and 20 years old, were pulled over at a light near 67th Street and South Chicago Avenue. They were brought into the police station at 51st and Wentworth just after midnight.
Police sources told FOX 32 exclusively that said a third party identified the alleged driver, the driver in turn gave up the alleged gunman.
That alleged gunman confessed to pulling the trigger, but said he did not intend to shoot or kill Hadiya Pendleton. The alleged gunman told police that he thought he was shooting at rival gang members, thought to be threatening their turf. He said it was all a mistake, according to exclusive information from FOX 32 police sources.
Chicago police also said that the community demonstrated great strength and unity in carrying out the "if you see something, say something" practice.
There is a $40,000 reward for the information leading to Hadiya Pendleton's murderer. Officers received a generous amount of tips and possible leads from residents, leading to these arrests. They have been working around the clock to solve Hadiya's murder, and wanted to thank the community for their assistance.
Chicago police are questioning the two suspects, and expect charges to be filed soon.
Hadiya Pendleton's family is cautiously optimistic but waiting until charges are filed.
"None of us will get our hopes up until as stated, there are charges, that is the only time we will get our hopes up… Per Cleopatra and Anthony, my cousins, the parents of Hadiya Pendleton, they have said that at this point, they have no statement to make, they will definitely make a statement as soon as there have been charges made for any individual that has caused this devastation to our family," said Pendleton's cousin, Shatira Wilks
The development comes less than 24 hours after Pendleton's funeral garnered global attention, with dignitaries and First Lady Michelle Obama in attendance.
FOX 32 News has confirmed Pendleton's mother received a phone call from Mayor Rahm Emanuel Sunday morning to inform the family of the case=breaking developments.
"The mayor has been very comforting to our family and I would not be surprised at anything when it comes to the mayor's level of comfort so him keeping Cleo posted on anything, there could be a lot of certainty to that," Wilks said.
Family spokesperson and cousin Shatira Wilks said there will never be closure.
"There's no closure when you lose a family member, a child, a parent losing a child, they never have closure. She will still cry the same tears that she cried at the funeral, 20 years from now," Wilks said.
Just blocks away from where the 15 year old lost her life, long time Hyde Park residents reacted to the developments in the case.
"When you do something like that, how can you live with yourself, you know what I'm saying and I know whoever they got, they have families too and it's actually hurting everybody, not only the family, the victim, everybody is being hurt by it so you know, crime doesn't pay," Dorothy Coleman said.
Michelle Obama to attend Hadiya Pendleton funeral
Hadiya Pendleton: Murdered teen becomes symbol of Chicago violence
Quinn visits family of murdered student Hadiya Pendleton
FOX 32 Sunday: Reporter's Notebook: Reporting on Hadiya Pendleton
Petition drawn up for Obama to attend slain teen`s funeral
Friends recall Hadiya Pendleton's final moments: EXCLUSIVE
Hadiya Pendleton tragedy: $40K reward in teen girl`s shooting death
Hadiya Pendleton: Community asks witnesses to come forward
Nation reacts to death of slain teen performer
PHOTOS: Teen killed 1 week after performing at inaugural events
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


text:
- Product Features
- Applications
- Specifications
- Documentation
- Photos & Videos
- Review
G40mm bulb shape.
- Dimmable LED Christmas Light Bulb.
- Warm White.
- E12 (Candelabra) Base.
- 2.5 inches long.
- 1.57 inch diameter.
- 3 LEDs per bulb.
- Very energy-efficient—only 0.96 Watt per bulb!
- 120 Volts AC.
- Dimmable, on the dimmers we list as compatible parts.
- 400 bulbs per plug recommended maximum.
- Up to 100,000 hour bulb life.
- Made by Minleon, a leader in LED Christmas light products.
- Lead was not used in the making of this product; however, the product you receive will not be labeled RoHS (Reduction of Hazardous Substances) because it was manufactured before we began labeling our Christmas lights RoHS. We will not accept returns of this product merely because of the lack of a RoHS label. If you require a RoHS designation, we have many products so labeled, either on the packaging or the product itself.
- Suitable for outdoor or indoor use.
- 1 year seasonal use limited warranty.
Retrofit LED bulbs are great for making your own custom strings or putting energy-efficient LED light bulbs into light strings that would be inconvenient to re-install as integrated LED light/strings. Use outdoors to enhance buildings, walkways, patios and foliage. Use indoors to decorate in bars, restaurants, nightclubs, malls and much more. Dress up just about anything with these energy-efficient LED light bulbs!
- Trees and bushes;
- Gutters and building trim;
- Trade show fixtures;
- Retail displays;
- Holiday decorations.
Light Color Warm White Bulb Shape G40mm Base E12 (Candelabra) Power (Watts) 0.96 Incandescent Equivalent 7 Watts Input Voltage 120 AC Input Current 8 mA Number of LEDs 3 Diameter (English) 1.57 in Diameter (Metric) 40 mm Max. Overall Length (English) 2.5 in Max. Overall Length (Metric) 63.5 mm Average Lifetime 100,000 hours Rating RoHS, UL, CSA Year Savings $1.76/year Lifetime Savings $121 Carbon Reduction 827 pounds Manufacturer Minleon Warranty 1 year seasonal use limited
Write Your Own Review


text:
- My Account
- Tell a Friend and Save
- Order Toll Free 1.800.727.9077
High Capacity Sweeper Bin, BlackItem Number: 81008
Holds three times more debris then the vacuuming bin.
In-Stock, usually ships in 1 - 2 full bus. days (Details)
In-Stock, usually ships in 1 - 2 full bus. days (Details)
Order Toll Free: 1.800.727.9077
You may also be interested in:
Advanced Power System (APS) 3000 mAh NiMH BatteryReplacement battery for all iRobot Roomba® 500, 600 and 700 S...Price: $69.99
High Capacity Sweeper Bin, Black Full Specifications
Oversized sweeping bin that holds three times more debris than the vacuuming bin and is ideal for use in larger spaces and dirtier, high-traffic areas. Compatible with all Roomba 500 Series models.
The iRobot limited warranty shall not apply to failures or problems which are caused by products or equipment not authorized by iRobot Corporation.
Country of Origin:China
Customer Reviews(Powered by PowerReviews.com)
Reviewed by 2 customers
Sort by
- Easy To Install
- Easy To Use
- Extends Functionality
- Inconspicuous Design
- Increases Performance
- Way more then above
- Not at all
Best Uses
- Commercial Use
- Larger Rooms
- Maintenance
- Upgrade
Comments about iRobot High Capacity Sweeper Bin, Black:
wow had wanted to make our 532 black and then we got the bin and it's way better then the one with the vac (since it drains the battery). we use this bin wednesdays and saturdays (when its scheduled to go) and in our dirty porch because theres alot of dirt, dust major amounts of pet hair there but otherwise its NOT ALLOWED THERE.
No filters to get
No extra battery power that roomba has to give off
easy to use/insert - remove
use everyday
- Easy To Install
- Easy To Use
- Extends battery life
- Extends Functionality
- Inconspicuous Design
- Quiet
- More dust than vac bins
Best Uses
- Basements
- Commercial Use
- Garages
- Larger Rooms
- Smaller Rooms
- Upgrade
- Workshops
Comments about iRobot High Capacity Sweeper Bin, Black:
I mainly use the High capacity sweeper bin in my garage where I unleash my Roomba 560 every few days to keep the floor relatively clean.
Things that are great are that it basically turns your exsisting Roomba into a shop vac. Also, as there is no vacuum in it, there is no vacuum motor to cause noise and use up battery power. Consequently, the Roomba will run a little longer on this bin (all other things being equal) than with a bin with a vacuum motor. It is also substantially more quiet without the vacuum motor. Last, it will also hold substantially more debris than other bins.
That said, it is what it is. Great for messes in areas where you don't mind more dust in the air that you would in, say, your living room. As there is no vacuum and filter actively sucking and filtering out dust particles kicked up by the action of the roomba's brush, there is bound to be more dust in the air.
My favorite, does-everything-great, bin attachment for the 500-series Roombas is still the AeroVac bin--which works WAY better than the stock vac bin with the squeegee-like vacuum nozzle, and can hold more debris than the stock bin (though not quite as much as this bin). That said, this bin is great for workshop type use and fairly clean households (probably pet-free ones) where there is probably not too much dust on the floor already. The High Capacity Sweeper bin is also substantially more quiet than both the stock bin and the AeroVac bin, so that might be an improtant factor for some people, too.


text:
Hi! My name is Jen, owner/designer of ReannaLily Designs, and this is my first recipe here at the Moda Bake Shop. I had a blast in the kitchen whippin' up a batch of Wine Gift Bags. The bags fit a standard 750mL wine bottle, but might be great for a bubble bath gift basket, as well.
This project uses just a few supplies and makes up 4 Gift Bags. They are each unique, scrappy, and original. These would make wonderful garden party centerpieces.
1 Charm Pack (Fresh Flowers By Deb Strain)
7/8 yard coordinating solid (30's Yellow)
Rotary cutting supplies
Hand sewing needle and thread
20" length of assorted ribbons
Open and sort the charm pack into 4 stacks of 9 charm squares each. Fresh Flowers has 4 colorways, so this project is sorted by color. You will have 6 charm squares left over.
NOTE: This tutorial will yield 4 gift bags. For photo reasons, we are working on only one.
Cut the 9 squares in half. You will then have 18" rectangles measuring 2 1/2" x 5 for each bag.
Cut the Bella Solid lining into 4 rectangles measuring each, 12 1/2" x 14".
Step 2: Build the Wine Gift Bag Exterior
Arrange the rectangles into 3 rows with 6 rectangles each. The project should look scrappy and random. You'll want to make sure that no two like fabrics are touching. Pay attention because when the bag is complete, the fabrics on the right hand side will be joined to the left hand side.
Use a 1/4" seam allowance to join pairs of rectangles to form rows.
Step 3: Press and Join the Rows
Join the rows to complete the exterior of the wine gift bag. The finished exterior should measure 12 1/2" x 14".
Step 4: Apply the Lining
Lay the right side of the lining onto the right side of the wine bag exterior. Match the 12 1/2" sides along the top edge. Join the two pieces using a 1/4" seam allowance along this edge.
Open the seam and press the seam allowances towards the solid. Edge-stitch along the solid lining fabric.
Fold the long rectangle in half lengthwise, matching the exterior side seams.
Sew around the bag, skipping the opening, using a 1/4" seam allowance. Sew completely across the short exterior fabric end.
Step 5: Create the Bag Shaping Darts in the Lining
Match the bag bottom seam with the side seam to form a triangle. Pin the triangle in place. Measure from the tip of the triangle along the stitched line 1 1/4". Make a mark.
Draw a line perpendicular to the seam line, along the mark. Stitch on the line. Repeat this for the remaining corner of the bag lining.
This will create the bag shaping darts. Remove the excess triangle fabric 1/4" past the stitching line.
Step 6: Turn the Bag Right Side Out
Turn the bag right side out through the narrow opening in the bag lining.
Push the corners of the exterior fabric to a nice crisp point.
Tuck the seam allowances of the lining opening into the opening and pin. You may either stitch this by hand to give a more invisible look, or edge stitch the opening closed as shown. (below)
Step 7: Finishing the Bag Exterior
Similar to the lining bag shaping dart, lay the side seam on the lower edge seam to form a triangle at each exterior corner. Pin this triangle shape.
Consider the three decorative options pictured (below)
1. {red} Leave the triangle as it is.
2. {orange} Fold the triangle up and hold it in place with a decorative button.
3. {green} Fold the triangle up and stitch it in place with a small, hand-sewn tack stitch.
Once the sides are finished, the bag is complete. Fill it with the bottled gift of your choice, fold the lining down to form a cuff and secure it with decorative ribbon.
4 Wine Gift Bags
Jen Eskridge
{ReannaLily Designs}


text:
It's a thrift shop and then some. The 20,000 square foot retail store doesn't sell clothes, but the ReUse Center on Industrial Highway in Ann Arbor sells just about everything else."It's things that people are donating that they don't have a use for anymore, but some of these items really still are in very good condition and someone else might have a use for them," said Recycling Coordinator Kendra Pyle.From glasses and mugs to clocks, books, cooking utensils, furniture and even the kitchen sink, we also saw children's bikes, exercise equipment and backyard grills all at bargain prices."I like the concept of things being reused," said Nancy Hummel. "I just don't like to see things go to waste."Hummel is a frequent shopper and has also donated truckloads of merchandise to the ReUse Center.Along with everything else they sell, they're known for their building supplies such as "Urbanwood," which can be made into beautiful furniture."If you're buying all this new stuff... there's an environmental cost to that, but if you're able to instead buy stuff that's used, not only is that stuff being prevented from going to a landfill, but you're also saving the environmental resources to go into new products," Pyle said.The ReUse Center is run by Recycle Ann Arbor, a nonprofit group that started the first curbside recycling program in the state in 1977. All of the money from sales goes back to the store and other programs. They're open seven days a week. Donations are accepted Monday through Saturday from 10:00 a.m. to 4:00 p.m. and Sunday from 10:00 a.m. to 1:00 p.m., and they're tax deductible."I think a lot of people do come here and they get ideas about really neat things to make from the things that they see here," said Pyle.The ReUse Center is encouraging people to think creatively. They want people to take old items and turn them into works of art as part of their Reuse Competition for Earth Day. The deadline is April 12. For more information, visit www.recycleannarbor.org.
WHBQ-TV | Fox 13 485 S. Highland St.Memphis, TN 38111Main Station: (901) 320-1313Newsroom: (901) 320-1340


text:
Back to Dressing up, Dressing down
For over a century from the 1660s to the late eighteenth century, fashionable men chose to shave their natural hair and to wear a wig instead. Over this long period, styles changed, but the procedure remained similar, necessitating the regular services of a barber for shaving, and to powder the wig, and a wig-maker or perukier to provide new wigs, maybe once a year, and to restyle used wigs. At first, large "full-bottomed" wigs were the fashion, like those worn by judges today, but as the eighteenth century wore on, smaller neater wigs were used, like those of barristers. New wigs were expensive to buy, costing perhaps £2 or £3 in the early eighteenth century, so poorer urban aritisans often bought second-hand wigs at about 8 shillings instead.
To make up their wigs, perukiers used different hairs, including horse or goat, or for the most costly wigs, human hair. Payments are recorded in household accounts to female tenants from male estate owners for lengths of cut hair which could be used for the long full wigs of the early eighteenth century. This very rare survival is made of white horsehair and was worn by Thomas Carill-Worsley who lived at Platt Hall from the 1760s. The prints below show a range of wigs being worn in mid to late eighteenth century life.
Full item descriptions:
"wig & bag" [1954.979/3]
Related Themes:
18th Century Men's Fashion
Collections search powered by KE EMu software


text:
Erna's Q & A
Who's your favorite sports team, and why?
Boise State Broncos is my favorite sports team because it's home team and also because they've made national headlines due to their impressive consistent successes.
What's your favorite movie quote?
"Sometimes you just have to say what the fuck" Risky Business
What's your favorite video game, and could you kick our butts at it?
Mario Kart....I used to play that game a lot when I was younger.
Piercings/Tattoos (How many? Where?)
I don't have any tattoos, I just have my ears pierced.
What's the most embarrassing song on your iPod?
Barbie Girl by Aqua! It never gets old.
What's the most memorable pick-up line you've ever heard?
None of them! haha
What's the most dangerous thing you've ever done?
The most dangerous thing I've ever done was going skydiving. There is nothing more scary that jumping out of a perfectly working airplane from 9000 ft.
It's 4AM after a crazy night out – what are we eating?
Ben & Jerry's ice cream.
What's the strangest thing in your fridge right now?
Baby food! I have it for when my little niece comes over.
What's the naughtiest thing you've ever done in public?
If I told you it wouldn't be naughty anymore ;)
What do you feel sexiest wearing?
Stilettos and skinny jeans.
Tell us a joke.
Why did the girl throw the butter out the window? She wanted to see a butterfly.


text:
I think the toughest thing to do in sports is to put a round bat to a round ball and hit it in a straight line. Oh, and you've got about ½ a second to pull the trigger on that bat. Oh, and that ball has some crazy a*s movement on it.
So…a dude, who fails over 70% of the time when he does pull that trigger, makes contact to the tune of 400 foot bomb, and he can't take a peeksy for a little bit? A pitcher can pump his fist, yell into his glove, point to the sky, go all K-Rod crazy on the hill if he secures a big one, but that's cool…you know, because he's not "showing up the hitter." When you watch the ball too long, trot too slowly, jaw back at a guy who first turns loose his tongue on you, then OH MY GOODNESS! How dare you?!
Carlos Gomez of the Milwaukee Brewers was one of 3 players tossed after this incident on Wednesday night:
I love that Gomez was chucked and not the Braves catcher (Brian McCann) who met him 10 feet up the 3rd base line to confront him for showing up his pitcher…a pitcher who, by the way, gave Gomez a nice heater to the knee back in June when these two teams met. Good work umping crew. Let's just permit players to dole out their own brand of wild west justice between the basepaths without any consequence. And then the crew allowed McCann into the huddle while they were sorting out the mess. Are you kidding me?
Baseball subscribes to more unwritten rules than any other sport, and each is subject to a unique contextual analysis. In this case, there is no incident if McCann just lets it go. And that's what a grown man on a playoff bound team should do when a punk on the 16 games under .500 opposition violates one of the unwritten rules of the game you play for a laughably comfortable living. McCann's inability to act like an adult put himself and his teammates in a potential suspension or injury scenario that is irresponsible for a squad that is gearing up for a pennant run.
Grow up, McCann. Get over yourself.
And baseball…maybe it's time we start writing down all of these unwritten rules.