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Chemo Regimen Shows No Benefit in Advanced Ovarian Cancer
Adding the chemotherapy drug topotecan to a standard first-line chemotherapy regimen in women with advanced ovarian cancer offers no benefit, according to the final results of an international phase III clinical trial published in the August 2 Journal of the National Cancer Institute. Patients who received topotecan also had higher grade hematological side effects such as low platelet and red blood cell levels.
Combined with similarly disappointing findings in other phase III trials assessing different chemotherapy regimens, these results suggest that standard cytotoxic chemotherapy drugs have run their course in ovarian cancer."Certainly we have pushed the available agents very far," said Dr. Edward Trimble of NCI's Division of Cancer Treatment and Diagnosis. "It's unclear where we go next with chemotherapy." Read more
Focusing on Cancer Stem Cells
Many solid tumors appear to have a small population of stem cells that are partially resistant to chemotherapy and can perpetuate themselves indefinitely. These cancer stem cells thus far have been isolated from breast and brain tumors as well as blood. The exact origin of these cancer stem cells remains to be defined.
With mounting evidence to support the hypothesis that genetic alterations in tissue stem cells may represent the origins of some cancers, the time is right to more vigorously explore the properties, mechanisms, and vulnerabilities of this subset of cells. The presence of such cells, first demonstrated in acute myeloid leukemia patients, provides a different and exciting model with which to further explore cancer biology. Read more
Chemo Regimen Shows No Benefit in Advanced Ovarian Cancer
Adding the chemotherapy drug topotecan to a standard first-line chemotherapy regimen in women with advanced ovarian cancer offers no benefit, according to the final results of an international phase III clinical trial published in the August 2 Journal of the National Cancer Institute. Patients who received topotecan also had higher grade hematological side effects such as low platelet and red blood cell levels.
Combined with similarly disappointing findings in other phase III trials assessing different chemotherapy regimens, these results suggest that standard cytotoxic chemotherapy drugs have run their course in ovarian cancer.
"Certainly we have pushed the available agents very far," said Dr. Edward Trimble of NCI's Division of Cancer Treatment and Diagnosis. "It's unclear where we go next with chemotherapy."
Dr. Trimble did stress that, in the appropriate patients, intraperitoneal delivery of chemotherapy has now proven to have a substantial benefit.
Ovarian cancer continues to be a highly fatal disease. Even patients who respond to initial treatments often have disease recurrence and die. In response, several large phase III trials have tested adding different chemotherapy drugs - including doxorubicin, gemcitabine, and epirubicin - to the currently recommended first-line therapy of paclitaxel and carboplatin. But, explained this most recent study's lead author, Dr. Jacobus Pfisterer of the Universtitatsklinikum Schleswig-Holstein in Kiel, Germany, none have demonstrated improvements in overall or progression-free survival compared with the standard regimen alone.
The current trial, led by French and German clinical trial groups, involved more than 1,300 women with previously untreated advanced ovarian cancer. Participants were randomized to the standard first-line therapy of six cycles of paclitaxel and carboplatin with or without four cycles of topotecan. The overall and progression-free survival rates were effectively the same.
In an accompanying editorial, Dr. William P. McGuire from the Weinberg Cancer Institute in Baltimore, argued that it was time to abandon testing new chemotherapy regimens in clinical trials and, instead, "use all our valuable patient resources to evaluate whether ovarian cancer responds to the targeted therapies as other solid tumors have."
A number of phase II clinical trials, and at least one phase III trial, are testing different targeted therapies in patients with ovarian cancer. Most of these trials involve anti-angiogenic agents.
There also is a randomized phase III trial pitting the trio of carboplatin, paclitaxel, and the anti-angiogenic agent bevacizumab (Avastin) against carboplatin and paclitaxel alone in women with advanced ovarian cancer.
According to Dr. Robert F. Ozols, senior vice president of Fox Chase Cancer Center in Philadelphia, bevacizumab has promise in this setting.
"What's striking is that bevacizumab has had activity as a single agent in ovarian cancer, whereas in other tumor types it has had very little activity [when used alone]," he said.
Although targeted therapies should be aggressively pursued, Dr. Ozols added, some investigational cytotoxic agents may yet have value against ovarian cancer.
"We still don't know whether some of the newer agents may have a benefit," he said. "I wouldn't abandon cytotoxic drugs just yet."
By Carmen Phillips
Focusing on Cancer Stem Cells
Many solid tumors appear to have a small population of stem cells that are partially resistant to chemotherapy and can perpetuate themselves indefinitely. These cancer stem cells thus far have been isolated from breast and brain tumors as well as blood. The exact origin of these cancer stem cells remains to be defined.
With mounting evidence to support the hypothesis that genetic alterations in tissue stem cells may represent the origins of some cancers, the time is right to more vigorously explore the properties, mechanisms, and vulnerabilities of this subset of cells. The presence of such cells, first demonstrated in acute myeloid leukemia patients, provides a different and exciting model with which to further explore cancer biology.
As a result, NCI is establishing a trans-NIH group of scientists interested in embryogenesis and cancer stem cell biology to advance the study of the underlying mechanisms in these processes. Establishing this group will facilitate the sharing of data, reagents, and animal models, and also provide a meaningful scientific interface with similar groups of extramural scientists.
Isolating and studying cancer stem cells should give us new insights into cancer and therapies. A defining characteristic of cancer stem cells is their ability to self-renew while giving rise to a diverse population of cells. In this respect, cancer stem cells are like embryonic stem cells, and the lessons of embryology, in which the role of stem cells are well defined, are crucial to understanding their role in carcinogenesis.
The mechanisms that allow controlled growth and migration of cells during the development of complex organisms from a single cell may be the same genetically programmed signal pathways that, when left unregulated in the adult organism, allow the development of tumors. Tumors are, in essence, complex "organs" complete with neovasculature and phenotypically altered supporting tissues.
Relatively little is known about the mechanisms of self-renewal, but researchers are beginning to identify potential genes and pathways involved. This could eventually lead to targets for intervening in the process, but without disrupting the behavior of normal tissue stem cells.
Some good news in this regard was reported last month. Researchers at the Dana-Farber Cancer Institute found differences between genetic signatures associated with self-renewal in cancer stem cells and in normal blood stem cells in mice. This suggests that it may be possible to target cancer stem cells in humans.
So where do cancer stem cells come from? One theory says they start out as normal stem cells until they become altered and start producing cancer cells. Another says that some more mature, differentiated cells may regain the ability to self-renew through genetic changes - a process of de-differentiation as they become malignant.
There may be evidence for both theories. It's important to remember that these rare cells have only recently been discovered. To answer fundamental questions about them, we need to develop more efficient techniques for isolating the cells and maintaining them in culture, and we need to draw on our knowledge of embryogenesis. Single-cell analyses will likely be needed to distinguish events present in cancer stem cells from the more differentiated cells that make up the majority of the tumor.
I am excited about the formation of this group. We have seen the success of another trans-NIH group in which NCI plays an integral role. The Trans-NIH Angiogenesis Research Program has improved the exchange of information and resources for angiogenesis researchers focused on diverse topics such as macular degeneration, cancer, and heart disease. Likewise, the new group has the potential to advance the science around stem cell biology and bring us closer to new and potentially highly effective therapies in cancer and other diseases.
Dr. John E. Niederhuber
Recommendations Focus on Imaging to Predict Treatment Response
NCI recently published new clinical recommendations on the use of the imaging technique known as FDG-PET in NCI-sponsored clinical trials. The recommendations, developed in collaboration with some of the nation's top researchers and clinicians in nuclear medicine and radiology following an NCI-sponsored workshop in 2005, apply to clinical trials where FDG-PET results are being studied as early indicators, or biomarkers, of response to treatment.
The premise behind the use of FDG-PET relies on the inner workings of tumor cells, which need a lot of energy to survive and proliferate. This need is so great that tumor cells will simultaneously use two different methods of consuming glucose to provide enough energy to fuel their activity.
FDG is a glucose analog with a radioactive tracer (F18) attached to it. Tumor cells, particularly those from especially aggressive tumors, will consume significantly larger amounts of it than normal surrounding tissue. The result is that FDG's presence can be detected by PET imaging in tumors as small as 1 cm.
Currently, FDG-PET is used in everyday clinical practice to help detect the presence of a variety of tumor types and to stage them (at initial diagnosis as well as for restaging after treatment), explained Dr. Lalitha K. Shankar, of the NCI Cancer Imaging Program and the lead author of the clinical recommendations.
More recently, though, researchers have been investigating whether FDG-PET results can predict treatment response early (in the first 2 to 6 weeks) after treatment. In these studies, the levels of "tumor uptake" of FDG are measured before treatment and then again a short time later to see if that uptake has decreased, signaling a decline in the tumor cell population.
For instance, a small clinical trial published last year, of patients with advanced ovarian cancer undergoing presurgical chemotherapy, showed that changes in FDG-PET, even after the first chemotherapy cycle, accurately predicted outcomes and had superior accuracy compared with standard response criteria.
Similar trials involving other tumor types - lymphoma, esophageal and lung cancer - also have had good results, said Dr. Anthony Shields, a medical oncologist at the Karmanos Cancer Institute at Wayne State University, who also develops radiopharmaceuticals for use with PET imaging.
"Now we need to know in detail the sensitivity and specificity of that measurement," Dr. Shields said. "We need to figure out how good it is at predicting response and whether you can change treatment based on the PET results."
What's been missing from the studies and small clinical trials done to date, Dr. Shankar said, is consistency in the technical aspects of how the imaging procedures are performed. This includes measures such as preparing patients for the imaging procedures (varying blood glucose levels, for example, can skew the results); the timing of when the procedures are performed after treatment; and analyzing the resulting images, which can be done in different ways according to a number of different variables.
Ensuring consistency in the clinical trials testing FDG-PET in this fashion will be critical to moving the field ahead, says Dr. Steven M. Larson, of Memorial Sloan-Kettering Cancer Center, who directs the Laurent and Alberta Gerschel Positron Emission Tomography Center there.
"FDG-PET is likely to be the best candidate for a qualified biomarker," Dr. Larson argues. "But it will need to be assessed in large, multicenter trials. That's why standardization of the procedures from site to site is so important - to improve the reproducibility of the test."
Implementing the clinical recommendations, published in the June 2006 issue of The Journal of Nuclear Medicine, in NCI-sponsored trials "gives us a good place to start the next series of evaluations of FDG-PET as a marker of therapeutic response," Dr. Shankar explains. "This way, we can better evaluate, in a more uniform fashion, whether FDG-PET can help as a biomarker for assessing treatment response in a variety of tumors, doing it as a correlative study within the context of a larger therapeutic trial."
Approximately 10 clinical trials approved by the NCI Cancer Therapy Evaluation Program (CTEP) are already working under the auspices of these recommendations, and Dr. Shankar is working with CTEP to ensure that other trials follow suit.
"The imaging and oncology communities have really welcomed this activity," Dr. Shankar says. "And our colleagues in the pharmaceutical industry have as well. They participated in the workshop last year, and they are also using these recommendations in their trials."
Because of the rapid changes in imaging technologies, including PET, the recommendations will be revisited every few years, Dr. Shankar notes. NCI is also interested in consulting with cancer centers and other institutions who wish to work the recommendations into their own single- or multi-institution trials.
By Carmen Phillips
In mice injected with mesothelin-bearing tumors, researchers observed a synergistic antitumor effect by combining the drug paclitaxel (Taxol) and an immunotoxin - a bacterial toxin genetically engineered to target cancer cells. The combination was more effective than either the immunotoxin, SS1P, or the drug alone, and caused long-lasting complete remission in these mice.
"Either treatment alone had a small effect, but together they had an effect that was clearly more than additive," says lead researcher Dr. Ira Pastan of the Laboratory of Molecular Biology in NCI's Center for Cancer Research (CCR). His team previously reported an additive antitumor effect from combining the antibody bevacizumab (Avastin) with SS1P. The new study, in the August 1 Clinical Cancer Research, is the first description of a synergistic effect between a drug and an immunotoxin.
SS1P targets the protein mesothelin. This drug is active against both mouse tumors and tumor cells from patients with mesothelioma and ovarian cancer, all of which express mesothelin. Dr. Pastan's team showed that paclitaxel, at a dose that by itself has minimal antitumor effect, greatly increased the antitumor activity of SS1P against the injected tumors. They did not see a synergistic effect when the same tumors were treated in culture.
The researchers are still investigating the mechanism responsible for the different results. "The effect is what is important," says Dr. Pastan. "Even if we don't understand the mechanism, we should be able to design better treatment for patients with mesothelin-bearing tumors."
His team recently completed phase I trials with SS1P for mesothelioma and ovarian cancer, and a phase II trial is being planned. The researchers believe a paclitaxel/SS1P combination would be a good treatment plan for ovarian cancer because paclitaxel alone is effective for ovarian cancer and SS1P showed minor responses to ovarian cancer in the completed phase I trial.
Loss of Cellular Motor Protein Contributes to Tumor Formation
Investigators in NCI's CCR have shown that loss of the cellular motor protein KIF4, which plays a role in mitosis, may contribute to tumor formation, according to a study in the August 8 Current Biology.
The investigators isolated mouse embryonic stem cells lacking KIF4 (KIF4 KO cells), and observed defects in mitosis leading to aneuploidy (abnormal chromosome number) in more than 70 percent of KIF4 KO cells. When KIF4 KO cells were injected into nude mice, they formed significantly more and larger tumors than control cells, likely due to an increase in cellular proliferation.
In further in vitro experiments, the investigators showed that cell-cycle checkpoints were overridden in KIF4 KO cells, and these cells were significantly more likely than control cells to contain aberrant centrosomes, organelles that organize the cellular microtubules during cell division. Loss of KIF4 caused activation of cellular DNA damage-response pathways, which is a sign of cells with potential to form tumor cells.
In a probe of human tumor cell lines, including ovarian, lung, breast, and central nervous system cancers, KIF4 was absent or underexpressed in 35 percent of samples, strongly suggesting a link between loss of function of this protein and human tumor formation. "These results are important for two reasons," says Dr. Tom Misteli, one of the paper's authors. "First, the demonstration of a link between a molecular motor and tumor formation represents a new paradigm in the fields of molecule motors and cancer biology. Second, although the hypothesis that mitotic defects and aneuploidy can be causative in tumor formation has been around for a long time, it has been very difficult to prove experimentally. Our experiments support this idea."
Prenatal DES Exposure Linked to Breast Cancer Risk
Daughters of women who took diethylstilbestrol (DES) during pregnancy have an increased risk of breast cancer after age 40, according to a study in the August Cancer Epidemiology Biomarkers & Prevention.
DES is a synthetic estrogen prescribed to many pregnant women between 1938 and 1971 to prevent spontaneous abortion. It's estimated that one to two million women had prenatal exposure to DES.
The study followed four cohorts of DES-exposed and -unexposed women identified from the National Cooperative Diethylstilbestrol Adenosis Project, a University of Chicago clinical trial, a Massachusetts private infertility clinic, and a study of health effects in mothers who took DES. The women completed questionnaires in 1994, 1997, 2001, and 2003 that gathered information on lifestyle, reproductive and hormonal factors, occurrence of cancer, and frequency of mammographic screening.
Researchers found that DES-exposed women aged 40 and older had 1.9 times the risk of breast cancer of unexposed women of the same ages. Women with the highest cumulative dose of DES also had the highest relative risk of breast cancer.
"These findings support the hypothesis that prenatal hormone levels affect breast cancer risk," said senior author Dr. Robert Hoover of NCI's Division of Cancer Epidemiology and Genetics.
"The study also highlights two important clinical implications: DES-exposed women should rigorously follow breast cancer screening guidelines and should carefully consider whether to take female hormone supplements," added study author Dr. Julie Palmer of Boston University.
CHEK2 Gene Mutation Increases Risk of Breast Cancer
A prospective study of more than 9,000 Danish women found that those who had a specific mutation in the tumor-suppressor gene CHEK2 had a threefold increase in the lifetime risk for breast cancer compared with noncarriers of the mutation, according to a study published online July 31 in the Journal of Clinical Oncology.
Previously, smaller case-control studies suggested an association between the CHEK2*1100delC mutation and cancers of the breast, prostate, and colorectum. Researchers, led by Dr. Borge G. Nordestgaard at Herlev University Hospital in Denmark, decided to study the prevalence of the mutation and its impact on cancer risk in the general population. They randomly selected 9,231 participants from the Copenhagen City Heart Study who had been monitored for an average of 34 years for cancer development.
They found that 0.5 percent carried the CHEK2 mutation. Among the women carriers, 12.5 percent developed breast cancer compared with 5 percent of noncarriers. Adjusting for other risk factors, the scientists found that carriers were 3.2 times more likely to develop breast cancer. However, they found no statistically significant association among CHEK2 mutation carriers for prostate, colorectal, or general cancer risk.
Dr. Nordestgaard commented: "The identification of CHEK2 as a biomarker gives us a better picture of the genetic risk factors, and may help to identify a significant subset of women who would benefit from more vigilant screening for the disease." Additional research is needed to identify if the study's findings apply to other ethnic groups, including blacks and Hispanics.
Synthetic Scorpion Venom Targets Brain Tumor Cells
The giant yellow Israeli scorpion kills its prey with venom that blocks chloride channels, but its bite is not fatal to people. The first human trial testing a synthetic version of the active protein in this venom, known as TM-601, shows that it may be a safe way to improve results in recurrent glioblastoma multiforme (GBM), a deadly brain cancer.
The drug is "simple to deliver, well tolerated, remains highly localized to the treatment site, and preliminarily seems safe for repeated injections," writes Dr. Adam N. Mamelak, of Cedars-Sinai Medical Center in Los Angeles, and colleagues in the August 1 Journal of Clinical Oncology.
The 18 adult patients in this phase I trial underwent surgery for GBM that had relapsed after first-line treatment. After removing all visible tumor tissue, surgeons implanted a small device under the patients' scalps with a tube leading to the surgical site. Two to 4 weeks later, when the patients had recovered from surgery, TM-601 tagged with iodine-131 was injected directly into the tumor cavity, with six patients each getting 0.25, 0.50, and 1.0 mg of the drug.
Patients had very few and only minor adverse effects 3 weeks after receiving the drug. Imaging showed that TM-601 attached almost exclusively to tumor cells, with very little residue elsewhere in the body. Two-thirds of patients achieved stable disease, and two women receiving the 0.50 mg dose had complete responses, no recurrent disease, and were still alive 37 and 39 months, respectively, after surgery.
Following are newly released NCI research funding opportunities:
Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis
This is a renewal of RFA-CA-06-001 and will use the R43/R44 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3517. Inquiries: Dr. Padma Maruvada - firstname.lastname@example.com
Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis
This is a renewal of RFA-CA-06-001 and will use the R41/R42 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3518. Inquiries: Dr. Padma Maruvada - firstname.lastname@example.com
For comprehensive information about NCI funding priorities and opportunities, go to http://www.cancer.gov/researchfunding.
The NIH Roadmap for Medical Research Funding provides a framework of the priorities NIH must address to optimize its research portfolio. It identifies the most compelling opportunities in three main areas: new pathways to discovery, research teams of the future, and re-engineering the clinical research enterprise. For information on additional Roadmap funding opportunities, go to http://nihroadmap.nih.gov.
Extending Immunotherapy for Metastatic Melanoma
Name of the Trial
Principal Investigator
Why This Trial Is Important
In adoptive cell transfer, tumor-infiltrating T lymphocytes, or TILs, are harvested from a patient's tumor(s), and the cancer-fighting properties of these cells are enhanced in the laboratory. The TILs are subsequently expanded (grown) to increase their numbers and then injected back into the patient. Adoptive cell transfer for melanoma focuses on TILs that target an antigen called MART-1, which is found on melanoma cells.
Tumor-reactive TILs cannot be obtained, however, from many patients. Thus, researchers have developed techniques to genetically engineer a patient's T lymphocytes to express the receptor protein that recognizes and binds to MART-1. The modified cells are then grown and infused into the patient.
This study will involve two groups of patients. One group will receive TILs containing transferred genes for the MART-1 receptor; the second group will receive T lymphocytes isolated from blood that also contain added MART-1 receptor genes.
"If these genetically engineered cells prove safe and show antitumor activity," said Dr.Rosenberg, "we plan to create lymphocytes that can target more common malignancies, including breast and colorectal cancers. There is tremendous potential here."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Two NCI Nurses Selected as AAN Fellows
Criteria for selection to the Academy include evidence of significant contributions to nursing and health care, and selection is based, in part, on the extent to which nominees' nursing careers influence health policies for the benefit of all Americans.
President's Cancer Panel Examines Lifestyles
Meetings of the President's Cancer Panel are free, open to the public, and require no registration. For more information on these meetings or the Panel itself, go to http://pcp.cancer.gov or contact Karen Parker at 301-452-9462 or firstname.lastname@example.com.
NIH to Host Conference on Health Disparities
The conference will focus on three broad areas influencing health disparities: policy, prevention, and health care. It will emphasize basic research on the behavioral, social, and biomedical pathways giving rise to disparities in health, as well as applied research on the development, testing, and delivery of interventions to reduce disparities in these three areas.
The agenda and registration information are available at http://obssr.od.nih.gov/HealthDisparities/index.html.
Surgeon General's Term Ends
The report, The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General, found that even brief secondhand smoke exposure can cause immediate harm to people's health. The report noted that the only way to fully protect nonsmokers from the dangerous chemicals in secondhand smoke is to eliminate smoking indoors.
Video Game Educates and Entertains Young Cancer Patients
Swiftly maneuvering through the blood stream, Roxxi, an RX5-E Class nanobot, spots a medulloblastoma cell. Roxxi pulls out a chemoblaster and lets loose with several rounds of green projectiles that seek and destroy the malignant cell before it can multiply.
Although it's a shoot-em-up video game - complete with a "Teen" rating - Re-Mission, the game that features Roxxi, is geared toward a very specific audience: teenagers and young adults being treated for cancer. Roxxi relies on an unconventional combat arsenal to battle bacterial infections, constipation, anxiety, and other treatment-related side effects.
Re-Mission, explained Dr. Steve W. Cole, vice president of research for HopeLab, the nonprofit organization behind the game, was designed to help young cancer patients better understand their cancer "and to do it in a way that helps them understand how their behavior impacts the biology of their disease."
In addition to offering a welcome distraction from treatment and side effects, the game reinforces the importance of things like sticking to a home chemotherapy regimen or taking a stool softener in the event of constipation - something that, left untreated, can be extremely dangerous, even fatal.
And it appears to work.
HopeLab - at the direction of its founder, Pam Omidyar, who worked as a research assistant in an immunology lab while pursuing a master's degree in molecular biology - put the game through the rigors of a randomized, controlled intervention trial. Involving 375 male and female patients aged 13 to 29, the trial demonstrated that, compared with patients who regularly played another popular video game, patients who played Re-Mission had better scores on psychosocial assessments such as quality of life. More important, though, patients who played Re-Mission had significantly higher chemotherapy blood metabolite levels and rates of antibiotic utilization.
"The upshot is that this game works," Dr. Cole said. "It shows that video games can be a powerful tool for behavior change in the real lives of patients."
Re-Mission was carefully developed to ensure that its presentation of different cancers was biologically precise, while at the same time ensuring that it had the elements of fun and challenge of popular video games. HopeLab recruited cancer researchers, doctors, nurses, and psychologists to work with experienced video game developers to craft Re-Mission's 20 stages, and HopeLab solicited feedback from and regularly tested the game with young cancer patients to make sure that it was fun, and above all, spoke to their situations.
"We have heard over and over from kids who played this game that 'This is about me and the issues I'm confronting,'" Dr. Cole says. "It's gratifying to hear them say that we hit the mark."
Re-Mission even has its own Internet community, http://www.re-mission.net, where young cancer patients, clinicians, and caregivers can order the game, free of charge. The Web site also has information about cancer and message boards and blogs.


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BBC Radio Wales joins the BBC World Service for a selection of news and current affairs, science and arts programmes to take you through the night.
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A pair of Florida fishermenhad a day at sea they won't soon forget.Kevin Johnsen from Florida Keys Reel Adventures, and fellow anglerAaron Osters, were fishing for lobster when they spotted a storm of the Floridacoast and decided to head towards it.
"We just happened to be at the right place at the right timein the right circumstances," Johnsen said via Skype.With wind speeds reaching near 70, Johnsen says the spouts caused his deckhatches to completely open and move the boat more than he expected.
"I can't stop shootingvideo. This is so awesome," says Johnsen during the 11-minute video.The pair and their dog were able to venture away unharmed with several minutesof incredible footage.
"I understand that everyone isn't going to comprehend whatwas happening to think this was a dangerous or reckless situation, when reallyit was no more or no different than a large dust devil which you'd encounter onland, but that you'd see on America's funniest home videos," Johnsen said.
While he may have put his own life on the line, Johnsen saysbetter to watch his video, than to try powering through a waterspout yourself.
"There is always an element of risk here. It's a calculatedrisk," Johnsen said. "There's inherentdanger anytime you're doing an activity like that."
Watch the full video here.
Material from myfoxdetroit.com was used in this report


text: Funeral services for Lisa C. Murphy will be held Sunday, Jan. 6, 2013 at 2 p.m. at Calvary Missionary Baptist Church in Minden. Officiating will be Rev. Jim Crain and Rev. Kevin Nobles. Interment will follow at Williamson Cemetery in Sailes under the direction of Rose-Neath Funeral Home in Minden. The family will receive friends from 5 until 8 p.m. today (Thursday, Jan. 3, 2013) at Rose-Neath Funeral Home.Subscribe to Read!


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DESPERATE HOUSEWIVES - "Opening Doors" - Bob stands by his man, on "Desperate Housewives," SUNDAY, MAY 4 (9:00-10:02 p.m., ET) on the ABC Television Network. (ABC/DANNY FELD) TUC WATKINS, KEVIN RAHM
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Does your wine taste like onions cooked in a beef stew? The answer is mevushal. Read on:
http://www.lodiwine.com/blog/flash-of-n ... -lodi-wine
Gabriel Geller wrote:How is it different from the way Hagafen (and I guess Herzog with the special reserve) 'mevushalize" their wines?
Isaac Chavel wrote:And I thought, from the discussions last spring/summer, that their (Hagafen & Herzog) secret was flash-heating before pasteurization. My memory faulty?
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Pope resigns in bombshell announcement, sending troubled church scrambling to replace him
VATICAN CITY (AP) -- With a few words in Latin, Pope Benedict XVI did what no pope has done in more than half a millennium, stunning the world by announcing his resignation Monday and leaving the already troubled Catholic Church to replace the leader of its 1 billion followers by Easter.
Not even his closest associates had advance word of the news, a bombshell that he dropped during a routine meeting of Vatican cardinals. And with no clear favorites to succeed him, another surprise likely awaits when the cardinals elect Benedict's successor next month.
"Without doubt this is a historic moment," said Cardinal Christoph Schoenborn, a protege and former theology student of Benedict's who is considered a papal contender. "Right now, 1.2 billion Catholics the world over are holding their breath."
The Feb. 28 resignation allows for a fast-track conclave to elect a new pope, since the traditional nine days of mourning that would follow a pope's death doesn't have to be observed. It also gives the 85-year-old Benedict great sway over the choice of his successor. Though he will not himself vote, he has hand-picked the bulk of the College of Cardinals -- the princes of the church who will elect his successor -- to guarantee his conservative legacy and ensure an orthodox future for the church.
The resignation may mean that age will become less of a factor when electing a new pope, since candidates may no longer feel compelled to stay for life.
Inheriting a troubled church, Pope Benedict XVI stumbled trying to fulfill ambitious agenda
Pope Benedict XVI set clear and ambitious goals for his papacy quickly after he was elected: He hoped to re-evangelize the increasingly secular West. He would show that religious faith and reason could co-exist in the modern world. He would reach out to traditionalists who had split from the church and shore up Catholic identity.
He came into the papacy with the reputation of a brilliant theologian; nearly eight years later, he leaves the Holy See with that reputation intact. But because of burdens he inherited and ongoing problems in his own pontificate, Benedict fell short of the mark he set for himself on unifying the church, building relationships with other religions and restoring the church's influence in broader society.
A look at some aspects of his legacy:
CHRISTIAN HERITAGE: Benedict dedicated his pontificate to stemming the spread of secularism, especially in Europe, where church attendance has dwindled. He condemned same-sex marriage, argued that gender had become something chosen instead of given from God, and said lack of belief was dangerous, pointing to violence that resulted when past atheist governments "tried to stamp out the light of God to instead turn on illusory and misleading glows." Yet even as he made his arguments, acceptance of same-sex relationships grew throughout Europe and the United States.
RESTORING TRADITION: Benedict wanted to restore Catholic traditions largely abandoned during the modernizing changes of the Second Vatican Council. The pope relaxed restrictions on celebrating the old Latin Mass. He streamlined the process for traditional Anglicans who, objecting to ordaining women and gays in their own church, wanted to become Catholic. He even donned pontifical hats and other clothing that hadn't been worn in decades. Many younger Catholics responded to his emphasis on orthodoxy and a stronger sense of Catholic identity. But many others were alienated. In the United States alone, studies have found Catholics dropping out of the church in large numbers.
10 Things to Know for Tuesday
Your daily look at late-breaking news, upcoming events and the stories that will be talked about Tuesday:
In many ways, the pope's nearly eight-year tenure fell far short, says AP Religion Writer Rachel Zoll.
With world's largest Catholic population, Latin America wants a Latin pope, but odds are slim
MEXICO CITY (AP) -- Latin America is home to the world's largest Roman Catholic population, but hopes that the next pope will come from the region appear faint, experts said Monday.
The predominance of Europeans on the College of Cardinals means that the odds are stacked against a Latin American pope, even though the names of a number of high-ranking churchmen from the region have been bandied about, analysts said. The 118-member college, with 62 European members and only 19 from Latin America, will elect a successor for Pope Benedict XVI, who announced Monday he will resign due to age.
Still, hope springs eternal.
"Since Latin America is a fortress for Christianity during these rough times, it would be healthy for us to get a Latin American pope," said Fernando Reyes, 57, a professional violinist, who prays daily at the La Merced church in Santiago, Chile.
Crossing himself before leaving the church, Reyes noted, "I would be proud. We've had Italian, Polish, German. It's time for a Latin American."
Obama to revive populist economic message in State of the Union, call for more tax revenue
WASHINGTON (AP) -- Reviving his populist re-election message, President Barack Obama will press a politically-divided Congress to approve more tax increases and fewer spending cuts during a State of the Union address focused on stabilizing the middle class and repairing the still-wobbly economy.
The agenda Obama will outline Tuesday before a joint session of Congress will include more money for infrastructure, clean energy technologies and manufacturing jobs, as well as expanding access to early childhood education.
White House spokesman Jay Carney said Obama would outline "his plan to create jobs and grow the middle class" as the nation struggles with persistently high unemployment.
Some of Obama's job ideas will be repackaged versions of proposals he made during his first term, though aides say there will be some new initiatives, too. All of the economic proposals are expected to echo themes from Obama's re-election campaign, which focused on using increased spending to generate jobs, protecting programs to help the middle class, and bringing down the deficit in part by culling more tax revenue from the wealthiest Americans.
Obama has called for raising more revenue through closing tax breaks and loopholes, but he has not detailed a list of targets. He and his aides often mention as examples of unnecessary tax breaks a benefit for owners of private jets and tax subsidies for oil and gas companies. Such measures are modest, however. Ending the corporate plane and oil and gas breaks would generate about $43 billion in revenue over 10 years.
Earthquake detected in North Korea near nuclear test site; no word on if it's from nuke test
SEOUL, South Korea (AP) -- An earthquake was detected Tuesday in North Korea just north of a site where the country has conducted nuclear tests. Neither Pyongyang nor Seoul confirmed whether the tremor resulted from a widely anticipated third nuclear test, though an analyst in Seoul said a nuclear detonation was a "high possibility."
The South Korean Defense Ministry, which raised its military alert level after the quake, said it was trying to determine whether it was a test. Nuclear blasts can create tremors but they are distinct from those caused by natural earthquakes.
A U.N. nuclear test monitoring organization detected what it called an "unusual seismic event" in North Korea.
The U.S. Geological Survey as well as earthquake monitoring stations in South Korea detected an earthquake just north of a site where North Korea conducted its second nuclear test in 2009, according to the government-funded Korea Institute of Geoscience and Mineral Resources.
"There is a high possibility that North Korea has conducted a nuclear test," said Chi Heoncheol, an earthquake specialist at the institute. Chi said a magnitude 3.9 magnitude earthquake and a magnitude 4.5 earthquake were detected in the North's 2006 and 2009 nuclear tests.
Military weighs cutbacks, shifts in drone programs to save money, face evolving threats
LANGLEY AIR FORCE BASE, Va. (AP) -- The Pentagon for the first time is considering scaling back the massive buildup of drones it has overseen in the past few years, both to save money and to adapt to changing security threats and an increased focus on Asia as the Afghanistan war winds down.
Air Force leaders are saying the military may already have enough unmanned aircraft systems to wage the wars of the future. And the Pentagon's shift to Asia will require a new mix of drones and other aircraft because countries in that region are better able to detect unmanned versions and shoot them down.
If the Pentagon does slow the huge building and deployment program, which was ordered several years ago by then-Defense Secretary Robert Gates, it won't affect the CIA drone strikes in Pakistan, Yemen and elsewhere against terror suspects. Those strikes were brought center stage last week during the confirmation hearing for White House counterterror chief John Brennan, President Barack Obama's pick to lead the CIA.
Gen. Mike Hostage, commander of Air Combat Command, said senior leaders are analyzing the military's drone needs and discussions are beginning. But he said the current number patrolling the skies overseas may already be more than the service can afford to maintain.
Overall, Pentagon spending on unmanned aircraft has jumped from $284 million in 2000 to nearly $4 billion in the past fiscal year, while the number of drones owned by the Pentagon has rocketed from less than 200 in 2002 to at least 7,500 now. The bulk of those drones are small, shoulder-launched Ravens owned by the Army.
Woman charged in Arizona killing of lover recalls beating, shows jurors injured finger
PHOENIX (AP) -- A woman charged with killing her lover broke down in tears Monday as she described for jurors how her relationship with the victim included satisfying his "deviant" sexual urges and how he once beat her, kicked her in the ribs and broke her finger.
Jodi Arias, 32, has spent four days on the witness stand recounting her troubled childhood marred by abuse at the hands of her parents, a string of bad relationships, and how Travis Alexander belittled her, cheated on her, call her derogatory names and used her to fulfill his sexual fantasies.
Arias will return to the stand Tuesday for a fifth day of testimony. She faces the death penalty if convicted of first-degree murder in Alexander's 2008 killing.
Prosecutors claim she killed Alexander in a jealous rage, stabbing and slashing him 27 times, slitting his throat and shooting him in the head.
Arias says it was self-defense after initially telling authorities she wasn't there. She then blamed it on masked intruders. She now claims Alexander attacked her, forcing her to fight for her life.
Adventurers re-enact Shackleton's epic Antarctic voyage, eating salami rather than penguins
WELLINGTON, New Zealand (AP) -- It's been lauded as one of the greatest survival stories of all-time.
Nearly 100 years later, a group of British and Australian adventurers have discovered why. They re-enacted Ernest Shackleton's journey to save his crew when their ship got stuck and sank in Antarctica's icy waters.
Tim Jarvis and Barry "Baz" Gray reached an old whaling station on remote South Georgia island Monday, 19 days after leaving Elephant Island. Just as Shackleton did in 1916, Jarvis and his team sailed 800 nautical miles (1,300 kilometers) across the Southern Ocean in a small lifeboat and then climbed over crevasse-filled mountains in South Georgia.
The modern-day team of six used similar equipment and clothes. But the harsh conditions forced several of them to abandon their attempt along the way.
"It was epic, really epic, and we've arrived here against the odds," Jarvis told his project manager Kim McKay after reaching the station, adding that "we had more than 20 crevasse falls up to our knees and Baz fell into a crevasse up to his armpits."
The do's and don'ts of Westminster: Primping pooches without PEDs (performance-enhanced dogs)
NEW YORK (AP) -- Scissors, blow dryers, bobby pins -- they're as much a part of the Westminster dog show as commands, crates and treats.
Take Sophie, for example. With perfectly trimmed pompoms and fluffed out fur, she's the very essence of poodle pulchritude.
What Westminster won't tolerate, though, are PEDs -- performance-enhanced dogs.
That means no tattooing a boxer's nose to make it more black, no braces for a pointer to straighten its teeth, no removing a basset hound's inner eyelid to improve its appearance.
"It goes against the spirit of showing dogs in their appropriate state," Westminster President Sean McCarthy said Monday, the opening of the two-day show.


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Since 1930, Butler Specialty Company has furnished America's homes with fine lines of occasional and accent furniture. Founded by two men during one of the bleakest eras in our nation's history, the Great Depression, Butler not only survived but thrived because of its commitment to producing quality furniture and staying in touch with home fashion trends.
That commitment lives on today. A family-owned company, Butler is operated by second and third generations. The Chicago-based corporation scours the globe to find the most efficient sources of production and finest materials for its world-class designs. When it began importing in the late 1970s, Butler became a leader in pursuing a global approach to the highest quality and value - a tradition that continues into the 21st century.
Butler uses only the finest-quality woods, veneers, and hand-carved craftsmanship in its collections. The Heritage Collection, Butler's flagship line, fuses enduring design, exquisite carving, and carefully selected solid mahogany and fossil stone into a classic line of home accent pieces.
All Butler collections are design-driven, immaculately crafted, and sharply priced resulting in exceptional value for North American consumers. Browsing through the bombe chests, hand-painted consoles, distinctive secretaries, decorative tables, popular British-inspired game tables, and other fine occasional furniture featured in this catalog underscores why Butler is recognized as a leader in occasional and accent furniture.
Product WarrantyA 1-year warranty from ship date is provided against material & workmanship defects. If you have specific questions about this product's guarantee, please contact our Customer Service department.
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The European Commission is further strengthening the Enterprise Europe Network with new contact points in Asia and Africa. The growing reach of the Network was evident at its annual conference, which welcomed more than 900 participants from 50 countries. The event featured awards to companies which have successfully used the Network to find opportunities abroad or to develop their business and research activities.


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Launch of the Redesigned WISENET
July 9, 2012
Launching the Broadband Partnership of the Americas
April 17, 2012
Second Annual Wireless World Travel Week
July 19, 2011
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Sightseeing: Vancouver; Capilano Suspension Bridge / Grouse Mountain / Victoria & Butchart Gardens; Whistler (Host Mountain Resort, 2010 Winter Games); local Fraser Valley Wineries.
Arts & Cultural Excursion: Explore the vibrant & dynamic cultural scene in Vancouver. Steveston Tour: Walk the boardwalk & visit the historic Georgia Cannery or go whale watching.
Seattle, WA. Transportation: Ski transfers to & from Whistler (Host Mountain Resort, 2010 Winter Games) & other resorts in BC as well as regular transfers within BC & to Seattle, WA.
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The National Weather Service has issued a hazardous weather outlook for the New Jersey-New York-New England region for later this week.
According to noaa.gov: "There is the potential for a coastal storm to impact the tri-state region Wednesday and Thursday. This storm has the potential to bring strong gusty winds, rain/wintry precipitation, coastal flooding and additional beach erosion to the tri-state area."
According to NBC.com, "The system wouldn't be another Sandy, but it could build off North Carolina next Tuesday, then move up the coast and affect New Jersey, Long Island and other hard-hit areas by Wednesday."
"The possible storm next week is not of the same make up as Sandy," prediction center forecaster Jim Cisco told NBC News, "though any more rain, snow or wind would certainly pose exacerbating effects on the impacted regions."
Says WXEdge.com, "Heavy rain and strong winds are possible and if the nor'easter does track along the coast, a strong easterly wind could cause moderate to major coastal flooding. With areas along the coastline already hit hard last week, any kind of storm could prove problematic. … Although there could be some snow in Connecticut, heavy snow is not likely. Any snow would likely be confined to the inland higher terrain and especially at the beginning of the storm."
In addition, temperatures are dropping, and overnight temps are predicted to fall into the 20s this week.


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An employee at the mobile phone store, 2114 W. Grant Line Road, was opening the business just after 9:30 a.m. Thursday, Jan. 3, when she heard the display alarms go off inside the store.
She then spotted "a large hole in the wall," the log states.
The employee told police that she noticed phones were missing from the displays as she left the store.
When officers arrived, they found the employee waiting at a next-door business, because the T-Mobile store was still unsecure.
A police report is expected.
Tracy police received 182 calls for service Thursday, Jan. 3. The following is a sample of those reports.
7:54 a.m.: A woman reportedly thought her purse was stolen at the Safeway gas station, 1987 11th St. She told officers that she left the purse inside an unlocked vehicle when she went inside the store to pay. She realized it was missing about an hour later.
9:56 a.m.: Police arrested a 31-year-old man who allegedly took a car from a residence on the 100 block of Hawthorne Drive. The victim told police that she was visiting her father at the residence, and the car was gone when she woke up from sleeping the night before. Police located the suspect and the vehicle about an hour after the initial report by the victim. It's unclear how they were located, but the police log noted the car was equipped with OnStar.
6:09 p.m.: Officers arrested a 24-year-old woman during a traffic stop in the area of Buthmann Avenue and Grant Line Road for possession of a controlled substance.
• This column includes a sample of items as reported in the Tracy Police Department dispatcher's daily log. Additional information is based on reports from officers and other law enforcement agencies. To report information anonymously about a crime: Crime Stoppers, 831-6847.


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FAIRHOPE, Ala. (AP) -- Most people think of New Orleans when they hear the words "Mardi Gras." But the Southern tradition is celebrated in plenty of other places along the Gulf Coast.
And it means big business.
Tourism leaders estimate more than 1 million visitors pour into the Mobile, Ala., area each season to watch the festivities. They spend money at hotels, restaurants and stores during the month-long celebration.
In Florida, Pensacola Beach's Mardi Gras schedule has 16 events, including a Moon Pie party, red beans and rice lunch and a shoe box float contest.


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Did you know that Inkgrabber.com accepts Open Billing for Schools & Government offices. Not only will we start you out on Net 30 terms, you'll also be assigned a personal Account Representative to handle all your ordering questions. We'll provide you with a unique login… making future purchases a snap. You'll even earn "InkPoints" with every purchase, redeemable for the gift card of your choice. What are you waiting for? Sign up as an Inkgrabber.com Corporate Account Today! Fax your purchase orders to: 800-742-7480 to get started.
Printer Ink & Toner – Net 30 terms available for Schools & Gov't OfficesPublished March 25, 2009 Corporate Accounts Leave a Comment
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THIS is why I get excited for E3 every single year. You get better looks at the games coming out in the fall. The trailer for the new Batman game was released a month ago and it didn't have much to offer. This one from E3 though? A LOT better!
You can see more about this game via IGN.
This looks like it's going to be awesome and I always love seeing how a character and game series is progressed from the original game.
What do you think? Like it? Hate it? Comment below.
Just Plain Joe is a video game and movie junkie who claims to have dressed up as Wolverine four times for Halloween and a TMNT at lease three. He hosts "The Joe Show" weeknights on 100.7 MixFM from 6p-11p in Terre Haute, IN.


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- 1 charm pack (I used Love U by Deb Strain)
- 1/2 yard of two different coordinating fabrics (one for each bag)
- 1 magnetic snap
- small piece of medium weight interfacing (4 inches by 15 inches is plenty)
- very small piece of heavyweight interfacing (2 x 4)
There are lots of good ways to dress up these bags: buttons, ricrac, ribbon, lace, felt appliques, etc. However, this fabric is so cute, I felt no embellishment was needed.
- 2 - 14 x 14 inch pieces for the bag lining
- 1 - 5 x 5 for inside pocket
- 1 - 5 x 9.5 for outside pocket
- 1- 5.75 x 15 for crayon pocket
- 2 - 4 x 14 for bag handles
- It works best to start at the bottom seam that you already made and work up to the top of the pocket.
- Make your lines as straight and as evenly spaced as possible, but don't worry if you get off. Once the crayons are in the pockets, they cover many mistakes.
- Make sure to snip all your threads.
You did it! Fill your bag with goodies: games, little toys, crayons and coloring books. Make your child's day with something bright to fill those winter hours. Then come visit me at Lilac Lane for even more great ideas!


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Graduate Education with a Purpose
The purpose of graduate education at the University of Mississippi was first articulated by the Aims and Ends statement associated with the organization of the Graduate School in 1927. The statement is as follows: "The student who undertakes graduate study should understand at the outset that work of this character implies more than the acquisition of knowledge under competent instruction. He or she should aspire to a degree of knowledge of a given subject in order to make a contribution that is of original and independent value. This does not imply that much of the student's energies are not still to be applied in the acquisition of facts universally accepted, a process that should continue through life, but in graduate study these facts are to be weighed, coordinated, and supplemented by the student's own contributions."
News & Events
Congrats to our own Dean Kiss!
Dr. Kiss Selected Head of Conference of Southern Graduate Schools
Track Your Application – To check the application status, log back into your online application and click the link under the Status column.
Graduate Assistants Health Insurance Program:UM requires graduate assistants to have health insurance or to participate in a University sponsored Aetna plan. For more information, click here.
3MT® Winners Announced! • 3MT® Winners' Videos.
Check out our spring 2014 Graduate School Newsletter!
Congrats to our new 2013 Phi Kappa Phi Initiates!
Effective October 1, 2013 – the Graduate School application fee is now $50.
ATTENTION Doctoral Students! The Survey of Earned Doctorates will only be accepted via online as we are no longer accepting the paper version. The link can be found HERE.
Electronic Submission of Thesis and Dissertations is now Available!
Click HERE for Instructions!
ProQuest Log In-Click HERE.


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The North Webster/Springhill Narcotics Task Force spent Tuesday in an arrest blitz in the northern part of the parish.
Lt. Shawn Baker, with Webster Parish Sheriff's Office, Springhill Police Chief Will Lynd, Springhill Det. Ronald Wedgeworth, Springhill Sgt. Sal Gonzalez, Springhill Det. Bryan Montgomery and Cullen Police Lt. Leon Thirdgill arrested four persons in the Springhill/Sarepta/Cullen area and served a warrant to one already incarcerated at Bayou Dorcheat Correctional Center (BDCC) for distribution of various drugs.


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Now, I understand it's ridiculous to put seitan on gluten free pizza dough, but I did. (and then I picked a good portion of the seitan off of my pizza)..
The other day, I made some Chipotle Garlic Seitan Sausages. They were a total clean out the fridge deal. For the liquid portion, I used some leftover Very Lowfat Balsamic Vinaigrette and chickpea cooking liquid. I added nutritional yeast, sage, chipolte, tons of garlic, fennel and cajun seasoning to the vital wheat gluten and pressure cooked them for 20 minutes.
I topped my pizza some Tangy White Cheese Sauce (I'm still tweaking this recipe.. ), caramelized onions, sauerkraut, seitan and my special sauce . I did add in some caraway seeds to the special sauce for a more traditional reuben flavor. Yum!


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A FREE service that allows you to get in touch with other fans who are interested in sharing a season ticket plan.
I have been a Yankees season ticket licensee for a number of years. When I mentioned to my Yankees representative that I needed someone to share in my ticket plan for this season, he directed me to the yankees.com Season Ticket Partner Zone. It was extremely easy to create the post about my tickets and it had all of the information and terms I was looking to include. Shortly thereafter, I started receiving inquiries about my listing, and it didnt take long before I was successfully matched with a season partner. Overall, the process was quick and easy, and I strongly recommend the yankees.com Season Ticket Partner Zone for anyone who is looking to share, or share in, a season plan.
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Thanks Kelly and Cait! I've needed the words of encouragement. I've just been so down. I hope you both are doing okay! You ladies really are so lovely and supportive!
I went to the doctor again today and spoke with an actual surgeon to get a referral for a surgeon in New York. He was SOOOOOOOO nice, I wish he'd be the one doing my surgery! He actually listened to me when I told them the dose and amount of pain killers was insufficient. He gave me 40 10mg percocets to get me through the 25 hour drive up north and the wait til I see the other surgeon. He actually showed me my MRI's and pointed out where things were supposed to be and where they weren't. He also shared with me that I have severe bone bruising on the bottom of my femur and top of my tibia and fibula, which the other doctor did not. I also came to find out that the other doctor NEVER LOOKED AT MY MRI?!?!?! He just told me what the MRI radiologist wrote in the report. UGH! He also pushed me to get a new brace from them that would have cost me $684 up front, out of pocket, and got real pissed off when I told him I'd look else where. I found the exact brace he wanted me to get from brace shop (dunno if I can link drop or I'd post it) and I got it for $160!! What a steal! I recommend if you need any sort of brace at all, go there! We even got it overnighted for like $40 which isn't all that bad.
He shared with me the troubling news that with part of my meniscus being ejected from my knee joint and the damage done to what was left in place that after surgery it might not ever heal, and that to replace my ACL I'll have to have part of the hamstrings in my thigh removed and be used as the replacement and I'll have a 10% chance of tearing the replacement ACL after surgery. That percentage I can live with though.
I'm kind of down in the dumps still, but feeling better, the pain is under much better control but I'm still kind of depressed.
We'll be leaving Florida Friday morning and starting our long trek to New York, the long drive comes with lots of pain, I think I'll manage but it still makes me panic stricken. Although with all the downtime here I've gotten at least another 4 inches of width done on my Afghan (that doesn't sound like much but the afghan is 9 feet long)


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Tin Cloth Hood
A hood compatible with select Tin Cloth Coats
To order by phone, please call 1-866-860-8906
A water-repellent hood specially designed to work with and Tin Cloth Coat or Jacket. this hood buttons over the upturned collar of your Filson coat or jacket. 2 snaps in front. Draw string cinch cord to tighten fit. Roomy enough to be worn over a cap. Cut away sides allow wide range of vision. Does not fit Tin Cloth Packer Coat or Double Logger Coat. Made in USA.
- Water Repellent.
- Formerly style #635H
Workwear, Field
Product Care
Wipe or brush clean only.
Made in USA of imported fabric.


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Rated 4.8 out of 5Â by 43 reviewers.
Men Casual Shoes
Classic Leather
White/White/Grey (9771)
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Rated 5 out of 5Â by Aric A classic. A backbone shoe for Reebok. This shoes is great. My dad when I was young never wore anything different. I didn't like the shoes at the time. I just bought a pair for their retro look. They are great. They will never go out of style, and the comfort and durability is insane. I hope Reebok never changes this shoe, nor stops producing it. A lot of people love this shoe. ! 1/16/13
Rated 5 out of 5Â by texasron I currently have both white a black versions of the Classic Leather shoe. I have to have a wide show, the regular style is way too narrow. It appears that the Classic no longer is available in a wide width and I find that distressing. I like the wide sole of the shoe because it gives stability when walking on loose surfaces. 5/7/13
Rated 5 out of 5Â by beckie60 This product has was what I thought it would be The product was great and looked very nice on my boyfriends feet. I was a product I ordered for my boyfriend and he liked them very much. 11/18/13
Rated 1 out of 5Â by Jim39 They quit making this design! These shoes were the best shoe I've ever worn and I wore them for many, many years. I hate to see that they quit making them. Towards the end of their run on this shoe I was buying them 3 to 4 pair at a time so that I could extend the time I had to be wearing this shoe. I currently have one new pair left and I'm wearing other versions that I bought as in an all white nurses version. I'm really sorry to have seen them go. I still look around stores that I visit when I'm out of town hoping to find a pair in my size that they haven't sold. I checked all of the worst ratings so as to get someone to read this. It can't have a good rating if you can't buy the shoe! 8/12/13
Rated 4 out of 5Â by null Truely Classic Husband has been wearing these for years. So glad I found the Reebok website because they are getting harder and harder to find. Fit well, although they are starting to run a bit smaller than they have in the past. Also, they don't wear as well as they used to. We go through them much more quickly. They are still a great value for the price. 12/12/11
Rated 5 out of 5Â by Arvid Ultimate Classic Back in the 70's I managed a sporting goods store. We sold these like they were going out of style. Of course they never did and never will. Quality with superb fit, great look and comfort never goes out of style. NEVER discontinue this shoe!!! 6/28/12
Rated 5 out of 5Â by null Love this classic style and brand I have used this style and brand for a long time but can't find it anymore in the regular department stores. 6/27/12
Rated 4 out of 5Â by Stewart Where are the black Classics for men? I've been wearing the black Classics for years, but now they are nowhere to be found for men. They are available for women, so why not for men? What gives? They work well particularly for daily urban walking, so please bring them back. 11/28/11
Rated 5 out of 5Â by JOEL Just What I Like I've worn Reebok for years. I have worn 3 different kinds that are all very similar. They seem to last on my feet longer then any shoe I have worn in the past. I tried many different shoes from other companies that just didn't feel or fit as well. Also if you are looking for a grown ups shoe that seems to form to you feet. Stays comfortable even after months of everyday wear. It doesn't look like a kids, flashy, overpriced shoe that has someone elses name on them. When I wear these, they are mine. They look good, and that's exactly what I want!! 3/1/12
Rated 5 out of 5Â by Howard Love these shoes I have been wearing Reebok Classics for years. I have a narrow foot and I can lace them without coming near overlapping. I can order them over the internet and I always know they will be comfortable right out of the box. 8/8/11


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By studying Swedish men who provided blood samples at age 60 and were followed for 25 years, researchers have found that the concentration of prostate-specific antigen (PSA) in the blood at that age was associated with the risk of developing life-threatening prostate cancer later in life. Although men with a concentration below the median (≤1 ng/mL) might harbor prostate cancer, the cancer was unlikely to be fatal. "These men could be exempted from further screening, which should focus on men with higher concentrations," Dr. Hans Lilja of Memorial Sloan-Kettering Cancer Center and his colleagues reported online September 15 in the British Medical Journal (BMJ).
A second report, also online in BMJ, analyzed data from six randomized trials, involving more than 380,000 men, to assess the benefits and harms of prostate cancer screening. The analysis did not support the routine use of PSA testing with or without digital rectal exam. "Screening leads to an increase in the diagnosis of early-stage prostate cancer that does not seem to translate into a benefit in overall survival and survival specific to prostate cancer," concluded Dr. Philipp Dahm of the University of Florida College of Medicine in Gainesville, FL, and his colleagues.
Together with the observational study in Cancer by van Leeuwen and colleagues showing a low risk of prostate cancer mortality among men ages 55 to 74 with a PSA level of 0.0-1.9ng/mL, there is accumulating evidence that it may be possible to identify a group at very low risk for prostate cancer death, experts in NCI's Division of Cancer Control and Population Sciences said.


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|Product Type: Executive and managerial chairs
|Upholstery Material: Polyester/Polyester blend
|Arm Type: Open loop
|Assembly Required: No
|Product Warranty: Limited lifetime
|Style: Contemporary
|Passive or Active: Passive
|Hooded Casters: Yes
|Arm Finish: Black
|Double Wheel Casters: Yes
|Base Finish: Black
|Cushion or Upholstery Fill Material: Foam
|Compatible Flooring: Carpet
|Foam Density: 1.8
|GSA Approved: Yes
|Number of Items Included: 1
|Fade Resistant: Yes
|Upholstered: Yes
|Mechanism: Pneumatic
|Swivel: Yes
|Back Height: High-back
|Back Type: Upholstered; Cushioned
|Headrest Included: No
|Footrest Included: No
|Big and Tall: No
|Twenty-Four Hour Chair: No
|Adjustable Height: Yes
|Tilt Control: Yes
|Waterfall Edge: Yes
|Lumbar Support: Yes
|Life Stage: Adult
|Quality Rating: Good
|Casters: Yes
|Heated Seat: No
|Heated Back: No
|Leg Type: Five-point rolling
|Armed: Yes
|Weight Capacity: 250 Pounds
|Commercial Use: Yes
|Eco-Friendly: Yes
|Country of Manufacture: United States
Questions & Answers
High Point Furniture Mid-Back Executive Chair with Arms
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Many of High Point Furniture's models include features like surface-height power/data plug-ins, extensive wire management and steel legs with wire management acess panels. Privacy screens that are available for most workstations provide visual privacy for enhanced productivity. High Point Furniture also offers and extensive range of mobile storage/filing units as well as laminate credenzas for compact work areas.


text:
What's constitutes generous giving? - Ministry Videos
Press the button below if you liked this video! Thank you! =D
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Toledo is a funky range of vibrant yellow coloured linear striped tiles which can be used horizontally or vertically to create an impressive feature. This pack covers 1.02m².
*Free delivery over £50 refers to home delivery orders placed on diy.com only. Charges refer to the value of goods being delivered and excludes delivery from stores or services. Excludes bulk delivery.
B&Q accepts the above cards and also offers a range of in-store financial services. Learn more
Buy online, return in store. Terms and conditions apply
Have a question or a problem, chat to our support team now.contact B&Q
© B&Q 2014 - Terms & Conditions


text:
42 U.S. Code § 2286b - Powers of Board
(a) Hearings
(1) The Board or a member authorized by the Board may, for the purpose of carrying out this subchapter, hold such hearings and sit and act at such times and places, and require, by subpoena or otherwise, the attendance and testimony of such witnesses and the production of such evidence as the Board or an authorized member may find advisable.
(A) Subpoenas may be issued only under the signature of the Chairman or any member of the Board designated by him and shall be served by any person designated by the Chairman, any member, or any person as otherwise provided by law. The attendance of witnesses and the production of evidence may be required from any place in the United States at any designated place of hearing in the United States.
(B) Any member of the Board may administer oaths or affirmations to witnesses appearing before the Board.
(C) If a person issued a subpoena under paragraph (1) refuses to obey such subpoena or is guilty of contumacy, any court of the United States within the judicial district within which the hearing is conducted or within the judicial district within which such person is found or resides or transacts business may (upon application by the Board) order such person to appear before the Board to produce evidence or to give testimony relating to the matter under investigation. Any failure to obey such order of the court may be punished by such court as a contempt of the court.
(D) The subpoenas of the Board shall be served in the manner provided for subpoenas issued by a United States district court under the Federal Rules of Civil Procedure for the United States district courts.
(b) Staff
(1) The Board may, for the purpose of performing its responsibilities under this subchapter—
(A) hire such staff as it considers necessary to perform the functions of the Board, including such scientific and technical personnel as the Board may determine necessary, but not more than the equivalent of 150 full-time employees; and
(c) Regulations
The Board may prescribe regulations to carry out the responsibilities of the Board under this subchapter.
(d) Reporting requirements
The Board may establish reporting requirements for the Secretary of Energy which shall be binding upon the Secretary. The information which the Board may require the Secretary of Energy to report under this subsection may include any information designated as classified information, or any information designated as safeguards information and protected from disclosure under section 2167 or 2168 of this title.
(e) Use of Government facilities, etc.
The Board may, for the purpose of carrying out its responsibilities under this subchapter, use any facility, contractor, or employee of any other department or agency of the Federal Government with the consent of and under appropriate support arrangements with the head of such department or agency and, in the case of a contractor, with the consent of the contractor.
(f) Assistance from certain agencies of Federal Government
With the consent of and under appropriate support arrangements with the Nuclear Regulatory Commission, the Board may obtain the advice and recommendations of the staff of the Commission on matters relating to the Board's responsibilities and may obtain the advice and recommendations of the Advisory Committee on Reactor Safeguards on such matters.
(g) Assistance from organizations outside Federal Government
Notwithstanding any other provision of law relating to the use of competitive procedures, the Board may enter into an agreement with the National Research Council of the National Academy of Sciences or any other appropriate group or organization of experts outside the Federal Government chosen by the Board to assist the Board in carrying out its responsibilities under this subchapter.
(h) Resident inspectors
The Board may assign staff to be stationed at any Department of Energy defense nuclear facility to carry out the functions of the Board.
(i) Special studies
The Board may conduct special studies pertaining to adequate protection of public health and safety at any Department of Energy defense nuclear facility.
(j) Evaluation of information
The Board may evaluate information received from the scientific and industrial communities, and from the interested public, with respect to—
Source(Aug. 1, 1946, ch. 724, title I, § 313, as added Pub. L. 100–456, div. A, title XIV, § 1441(a)(1),Sept. 29, 1988, 102 Stat. 2079; amended Pub. L. 101–510, div. C, title XXXII, § 3202,Nov. 5, 1990, 104 Stat. 1844; Pub. L. 102–190, div. C, title XXXII, § 3202(a),Dec. 5, 1991, 105 Stat. 1582; renumbered title I, Pub. L. 102–486, title IX, § 902(a)(8),Oct. 24, 1992, 106 Stat. 2944; Pub. L. 112–239, div. C, title XXXII, § 3202(g),Jan. 2, 2013, 126 Stat. 2220.)
References in Text
The Federal Rules of Civil Procedure, referred to in subsec. (a)(2)(D), are set out in the Appendix to Title 28, Judiciary and Judicial Procedure.
2013—Subsec. (j)(2). Pub. L. 112–239substituted "section 2286a (b)(1) of this title, the implementation" for "section 2286a (1) of this title, the implementation".
1991—Subsec. (b)(1)(A). Pub. L. 102–190, § 3202(a)(1), substituted "150" for "100".
Subsec. (g). Pub. L. 102–190, § 3202(a)(2), substituted "Notwithstanding any other provision of law relating to the use of competitive procedures, the Board may" for "The Board may".
1990—Subsec. (b). Pub. L. 101–510designated existing provisions as par. (1), redesignated former pars. (1) and (2) as subpars. (A) and (B), respectively, inserted "including such scientific and technical personnel as the Board may determine necessary," after "Board," in subpar. (A), and added par. (2).
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
An empty table indicates that we see no relevant changes listed in the classification tables. If you suspect that our system may be missing something, please double-check with the Office of the Law Revision Counsel.
|Description of Change
|Session Year
|Public Law
|Statutes at Large
|§ 2286b
|112-239 [Sec.] 3202(g)
|126 Stat. 2220
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


text:
Used Cars & Pre-Owned Nissan Cars in Kalamazoo, Michigan
Welcome to the used car inventory page of Cole Nissan. You'll see from our selection below that we have one of the best selections of used cars in Kalamazoo and the greater Portage, MI area, and we know that we have a used car, truck, mini-van or SUV near Portage for you! Take a look, and then call us at (866) 216-4931 with any questions; or stop by 3003 Stadium Dr. Kalamazoo, MI. 49008 for a test drive. Get driving directions from Grand Rapids.
Call Today For Special Internet Pricing


text:
Just thought I'd share these with you.
Happy fractaling!
|Deviant Login
|Join deviantART for FREE
|Take the Tour
1500 Points Raffle 1500 Points raffle
How to join
just fave this journal
The raffle will end in 3 days
[CLOSED+WINNER] Adopt Raffle 09 - MemoriesHi \;///v///;/ Thanks again for the support T////T I receive so many comments ;__; all so kind T////T
nnngh you have so wonderful idea for them ;__;
Forgive again for the late Now I have the winner of the raffle \;//v//;/ <3 <3 <3
This is :iconAzaikar: waaaah I'm so happy for you T////v////T <3 <3 <3 \;//v//;/
Now Azaikar can choose her favorite in the batch and the others will be put on sale \;//v//;/ ( I'll make a poll before sell them ;u; <3 <3 )
THANKS A LOT AGAIN TO EVERYONE *cries* ç__ç I feel very happy T////T <3 <3 <3
Feel free to remove the journal from fav if you wish
Waaah such a long time we didn't make a raffle >///v///<
We really love doing that so this time we try with our new project "Memories" , Little Owl/penguin ( x°D )
We hope you like them \;///v///;/
7 tips for the 21 year old me
7 TIPS FOR THE 21-YEAR-OLD ME by Bobby Chiu
When I was a student in college working on my skills as a character designer, I'd had periods where I would sit at my desk working as hard as I could but having little to show for my efforts at the end of the day. I remember sitting there surrounded by blank pieces of paper, trying to come up with an amazing style that nobody had ever seen before. I would do one drawing and not be satisfied, so I would lay a new piece of paper over it, re-draw it with slight changes to features here and there. This would still not be good enough so I would put another piece of paper over my revision, make more minor adjustments trying to perfect this new style I was searching for.
I did this for weeks on end, tweaking and polishing over and over, working hard every day. But in the end, did I come up with a brand new style, something amazing that
2500 Point Giveaway [OPEN] #5
Hi guys!
Just for anyone interested and/or that is really needed points, simply follow info.
*and if you want help, please contribute a small or big donation, would be a great value! ♥
Enter in my profile page: ~~Help-donate-points~~
---------- ----------
I would like to thank the support of&
RAFFLE - TWO WINNERS. 2 DAYS LEFT!!Hello~ /O/
First, sorry for the inactivity. _(:'3_
I haven't been at my house these months and I had trouble getting internet.
But now I'm back and I hope that everything returns to normal.
So I wanted to make a raffle to celebrate it. xD
- Only watchers. u/v/u
- Fav this journal to get a number.
- Make a new journal entry linking to this raffle or make a poll about it!
- Leave a comment here linking me to your journal entry/poll.
THE RAFFLE ENDS SEPTEMBER 20th.
Winners will be selected with ramdon.org.
Thigh-up or Chibi.
Your character in Missing Halloween! (RESULTS)MISSING HALLOWEEN
In August 21, "Your character in Missing Halloween!" mini-contest was announce.
In September 1, a total of 313 character designs were submitted. Judging has begun.
As the judge, there were 313 submissions, and only 32 to choose from. Trust me, it was haaaarrd! It still pains me that so many great designs didn't get in. (It's just that many) But I still did my best to judge them carefully.
So here goes, the results!!!
As mentioned, there will be 5 characters who will be featured as candy givers! (And their owners to be in the credits as "Additional Character Design")
And here they are!!!
:iconAndrea4You: Andrea4You's character: Akai
:iconSkunkyfly: Skunkyfly's character: Amber
:iconShiroXIX: ShiroXIX's character: Pydur
:iconinkstainkat15: :d
Art RaffleWhee, I survived my exams!
And to celebrate that I'm going to do the long overdue art raffle:
Prizes will look like this:
Rules will be the same as last time:
1. You have to comment on this journal (I will give you your number then)
2. You have to fave this journal
3. You have to watch me
You can get one extra number if you promote the Raffle in your own journal and give others the chance to join, too.
Also, please be fair and don't use second accounts to get better chances. I will take a look at each account to be sure of it's activity.
I will use RANDOM.ORG to generate the winners on the 20 September.
.tell me anything, give me a poem -
let me walk through the night with light
in palms outstretched and melt the dark,
pour salt and time and swim
right through the net, fresh water
brimming diamonds in the sun, i hit the ice
and rise as steam, a shepherd of the air, a gentle ghost
that hears the scrubbing of her grave -
and i am still afraid of needles in my skin
from mother death, she said she birthed too soon
a life that kept its eyes shut to the world, the best,
she told me, i had skin of bark, so thick and strong,
my veins like branches, they'll feel holy
to the birds, got roots that go straight down to hell, when will i learn
that there is no grace to be found in hanging
from a tree, my neck is twice as strong as mary's, but in my body
way down deep,
there's something turning fitfully
in sleep
(and it knows more than i do)
My Anniversary Raffle!Hello Pups!!
The title says it all~!! i will be ooooopening a big (well not really) raffle for the people who watched me and has supported me for this first year of mine in deviantart!!! i seriously didnt really plan to stay here that long.. i thought that no one would even take notice of me and support me when i was new here.... and leave like 2 months later~ XD seriously! QWQ but now, its like im part of an amazing community and i want to thank u all for sticking with me.. QWQ thnak u!!
so as a thank u~ i will be opening a raffle here!! >w< there will be 3 pups and all of them will win different art and a few other pups who will win points from meeeeeeee! XDDD so to join in the raffle, U MUST...
-be a watcher!! (cause this iss a thank u for my watchers)
-fave this journal (cause y not!! XD)
-make a journal or poll for this raffle and comment it below!!! (cause i see that they do that whenever there is a raffle~)
pretty much thats it to join this weird raffle~ QWQ
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scheinbar is a much-loved and well-known deviant. Just one look at her gallery, filled with enchanting photography, will have you mesmerized. A deviant for over 7 years, Christiane can always be found posting inspirational features as well as regularly commenting on other deviations and encouraging and empowering her fellow deviants. We are inspired and insist that you too stop by and congratulate ... Read More
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Check out what our Members are up to
I am thrilled to announce that we now have a…
New "Theme of the Month" for September
There are some good ideas for TOTM in the suggestion box already but if anyone has some more, add them there.Read more…
Unidentified Cissy Doll
Hello All, Once again I'm hoping to get some information on a doll that was owned by my wife who is no longer with us. This is one of several Madame Alexander 21" DSC08497.JPGCissy dolls she had, but this one is nude and orphaned from her box and…Read more…
New Members: What do You Want to Get From This Community?
I thought it might be fun for new members to let us know what they hope to get out of being a member of our community. Is it meet other fashion doll collectors? Is it to share photos and get tips? Is it something entirely different?? There is no…Read more…
Comparison of Fashion Doll Lines - Looking for Recommendations
Can anyone recommend a website or other resource that provides reviews/discussions of fashion doll lines? I've found some good blogs that discuss new dolls as they become available (The Doll Observer, Collecting Fashion Dolls, Dolldom, Dolly Daily,…Read more…
Calling all Fashion Doll Hairstyle Experts
Haute Doll Magazine are looking for members of the site who have a penchant for styling their fashion doll's hair. I know there are lots of you out there! They also want to see how this can be translated into a tutorial with photography. Can you…Read more…
IFDC VIDEO PRESENTATION VIDEO of DEMI COUTURE DOLLS
JAMIEshow IFDC 2014 from George G. on Vimeo.Read more…
Theme of the Month163 Themers
Sew Much Fun99 Members
Fashion Doll OOAK - Repainting and Customization42 Members
Monster High Dolls49 Ghouls
Paper Doll Love6 Members
Once Upon a Time...16 Members
dabbling in the dark, goth dolls and fashions24 Members
Superdoll Collectables Dolls - The sYbarites70 sYbaholics
Kelly Dolls and Friends Group13 Members
Buy & Sell Fashion Dolls106 Collectors
Shoot Tips and Tricks27 Doll Photographers
Barbie77 Members
"The BEST doll site on the web" – Mark, USA
DollObservers.com is an online community for fashion doll lovers and collectors. Whether your passion is Barbie, Tonner, Sybarite, Fashion Royalty or all of the above! Or whether you prefer your dolls Vintage or New, then this is the site for you.
Once you sign up you will be able to enjoy and join in with the following activities and features:
- Have your own personal 'My Page'
- See a member you like? Add them as a friend! The more you engage with other members the more friends you will make. Invite your non-member friends to join you too!
- Active members stand the chance of being nominated as a Superstar Member!
- Upload your Doll Photos, tag them and add them to Groups too. Other members can comment and socially engage with them
- Join in and engage with the fashion doll discussions in the Forum
- Join a specific Doll Groups such as 'Barbie", 'Buy & Sell', 'Tonner Dolls', 'Sybarites' and more. Don't see a group for you? Then create and maintain your own!
- Follow all the action in the Activity Feed on the front page in order to keep up with members' posts. You can also add Status Updates, Links and YouTube videos right there in the feed!
- We have a regular Theme of the Month photo contest. Previous themes have included 'Science Fiction', 'In The Sun', 'Love' and lots more.
- Look out for occasional offers and competitions to win cool Fashion Doll prizes!
We are a true community of doll lovers and together we can discover a whole world of Fashion Dolls!