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Advisory Committee Recommends Against Approval of Two New Cancer Drugs
An advisory committee to the U.S. Food and Drug Administration (FDA) last week recommended against the approval of two drugs for the treatment of advanced melanoma and brain metastases, respectively. In both cases, the drugs' manufacturers had submitted applications for FDA approval of their products based on the results of a single phase III clinical trial in which the drug did not achieve the trial's primary endpoint.
During its May 3 meeting, the FDA Oncologic Drugs Advisory Committee reviewed data on efaproxiral (RSR13), a "radiation sensitizer" intended to be used as an adjunct to radiation therapy to make it more effective, and oblimersen (Genasense), part of a new class of "antisense" drugs thought to inhibit the production of proteins that protect cancer cells from treatments like radiotherapy and chemotherapy. Read more
Providing Support for Children and Their Families
As we all are painfully aware, cancer can devastate a family. But as many of us have seen, those who have suffered through a bout with cancer or lost a loved one to cancer often respond by trying to help others like them.
Russ Sanford and his family fall into this group. In June 2002, 10-year-old Joe Sanford died after a courageous, 3-year fight with medulloblastoma, a form of brain cancer that typically afflicts children and young adults. The Sanford family underwent the roller-coaster ride that all families do when one member battles cancer - treatment successes and setbacks, periods of calm, and periods of mania. Read more
Advisory Committee Recommends Against Approval of Two New Cancer Drugs
An advisory committee to the U.S. Food and Drug Administration (FDA) last week recommended against the approval of two drugs for the treatment of advanced melanoma and brain metastases, respectively. In both cases, the drugs' manufacturers had submitted applications for FDA approval of their products based on the results of a single phase III clinical trial in which the drug did not achieve the trial's primary endpoint.
During its May 3 meeting, the FDA Oncologic Drugs Advisory Committee reviewed data on efaproxiral (RSR13), a "radiation sensitizer" intended to be used as an adjunct to radiation therapy to make it more effective, and oblimersen (Genasense), part of a new class of "antisense" drugs thought to inhibit the production of proteins that protect cancer cells from treatments like radiotherapy and chemotherapy.
Efaproxiral was being considered as an adjunct to whole brain radiation therapy (WBRT) for brain metastases in patients with breast cancer. Approximately 20-30 percent of breast cancer patients develop brain metastases. In a 538-patient, randomized, open-label trial, the combination of WBRT and efaproxiral failed to improve overall survival compared to WBRT alone. A subgroup analysis not called for in the original trial design, however, found that the WBRT/efaproxiral combination nearly doubled the median survival rate of breast cancer patients with brain metastases compared to WBRT alone (8.67 vs. 4.57 months).
In its own review, the FDA argued that the subgroup analysis was prone to false-positive results. The committee appeared to agree, voting 16-1 that the data presented "did not constitute substantial evidence of efficacy." In February, Allos Therapeutics launched a similar phase III trial, but with breast cancer patients as the intent-to-treat group. The committee agreed that replication of the first trial's results in this subsequent trial would likely smooth the path to FDA approval.
With oblimersen, the committee was again faced with data from a phase III trial that failed to meet its primary endpoint of improvement in overall survival. In a 771-patient trial, patients with advanced metastatic melanoma were treated with dacarbazine (a standard chemotherapy agent) and oblimersen, or dacarbazine alone. New treatments for advanced melanoma have been sparse, yet they are desperately needed. Advanced melanoma is the most lethal form of skin cancer and melanoma incidence has increased more rapidly than any other cancer, more than doubling in the last 30 years.
Although the oblimersen/dacarbazine combination did not improve overall survival compared with dacarbazine alone, it did appear to improve progression-free survival (74 days vs. 49 days) and the antitumor response (11.7 percent vs. 6.8 percent). Based on that and other data, the committee voted 11-5 that the combination had a real effect on response rates.
However, again agreeing with the FDA assessment, committee members felt that the data may not be providing an accurate picture. Committee members questioned the differences in patients' assessment schedules to measure progression-free survival and the process by which tumor response analysis was conducted, both of which could have significantly biased the results. As a result, by a 13-3 margin, the committee voted that the data presented could not be considered substantial evidence of effectiveness.
According to Dr. James Zwiebel, of the National Cancer Institute's Cancer Therapy Evaluation Program, NCI is currently sponsoring 18 studies of oblimersen to treat a variety of both solid and hematologic malignancies. In addition, results from two pivotal phase III trials of oblimersen that Genta has sponsored, in chronic lymphocytic leukemia and multiple myeloma, are anticipated by the end of year. NCI is also sponsoring a phase I/II study of efaproxiral in patients with progressive or recurrent high-grade gliomas.
Providing Support for Children and Their Families
As we all are painfully aware, cancer can devastate a family. But as many of us have seen, those who have suffered through a bout with cancer or lost a loved one to cancer often respond by trying to help others like them.
Russ Sanford and his family fall into this group. In June 2002, 10-year-old Joe Sanford died after a courageous, 3-year fight with medulloblastoma, a form of brain cancer that typically afflicts children and young adults. The Sanford family underwent the roller-coaster ride that all families do when one member battles cancer - treatment successes and setbacks, periods of calm, and periods of mania.
In the last months of his battle with cancer, Joe was enrolled in a clinical trial conducted at the National Institutes of Health. Russ and his wife, Betsy, responded to their son's odyssey by launching the Joseph Patrick Sanford Memorial Foundation, which raises money and donates acts of service and funds to help meet the needs of suffering children and also gives to organizations that touched Joe's life during his battle with cancer.
The proceeds from the Foundation's first annual "Joe's Ride" fundraising event were donated to the Children's Inn on the NIH campus. The Inn is a place where children participating in NIH clinical trials and their families can stay when they need to be on campus for treatments over an extended period. Patients being treated in NCI trials are the largest majority of Inn visitors, accounting for approximately 36 percent of annual visits.
A new wing of the Children's Inn was officially opened during a touching ceremony last week. The new wing, which will house 22 additional families, was desperately needed. In 2003, 400 families' requests to stay at the Inn - instead of at nearby hotels, which is often their only resort - had to be denied. There simply wasn't enough room.
With this new addition, at any one time 59 families can call the Inn their home - for a short while at least. The Inn really is a "home away from home" for patients and their families, providing comfortable accommodations, fun events, and the opportunity for families to interact, commiserate, and lean on one another. The Inn is a model for caring for the whole person - a recognition that quality care extends well beyond the hospital or clinic.
When you're embroiled in the enterprise of cancer research - investigating the genetic and molecular origins of cancer, using advanced technologies to search for biomarkers of disease, performing secondary analysis on large clinical trial results to look for interesting trends - it's easy to lose sight of the patients and families who are affected by this disease. But compassion is and must continue to be as much a part of our culture as intellectual excellence is.
At NCI, we are truly committed to palliative care and quality-of-life issues. We are sponsoring research into a number of supportive care areas, including pain management, depression, nutrition, and stress management, and others. The bottom line is that when somebody is diagnosed with cancer, they don't abdicate their right to a sense of normalcy and comfort.
The second annual Joe's Ride is scheduled for this coming weekend. Proceeds from events like this and foundations like the one established by Joe's family, helped make this new wing possible. And these same patients and families staying at the Inn while participating in a clinical trial are benefiting children now and in the future by helping to advance clinical research. That is a true circle of life.
Dr. Andrew C. von Eschenbach
NCI Boosting Ranks of Minority Cancer Researchers
Last week in a hotel in the suburbs of Washington, D.C., a room of young cancer researchers gathered to learn about some grant opportunities available to them through NCI, receive guidance on keeping their careers moving forward, and network with their peers. Although not an unusual event in any respect, this particular workshop did offer one unique aspect: attendees were all from groups of underrepresented minorities in cancer research. The workshop was sponsored by NCI's Comprehensive Minority Biomedical Branch (CMBB).
"You're going to take us to 2015 and beyond," NCI Director Dr. Andrew C. von Eschenbach told the attendees. "And that's why it's so critically important that we do everything possible now to make certain that your careers are nurtured and that you have the tools and opportunities available to you to flourish."
In 1975, NCI leaders and researchers formed the Comprehensive Minority Biomedical Program to encourage minority individuals to choose and participate in biomedical research careers. Since then, the program has evolved into the CMBB.
CMBB's ambitious goal, says its director, Dr. Sanya Springfield, is to "significantly increase the number of underrepresented minorities participating as competitive NCI/NIH-funded cancer researchers." To this end, CMBB has pursued three main strategies:
One of the CMBB's most successful efforts has been the Continuing Umbrella of Research Experiences (CURE) program. This program directs long-term funding to qualified minority students interested in scientific, cancer research-related careers.
CURE builds on the success of the Research Project Grant Supplement Program, Research Supplements for Underrepresented Minorities, through which minority students can apply for supplements throughout their academic careers and combine these with numerous other programs as they move through college undergraduate, graduate, and post-doctoral programs. In 2003, CMBB, through CURE, allocated $26 million to 304 minority applicants at various stages in their academic careers, under individual grant and supplement programs.
CMBB also supports efforts of NCI Cancer Centers and other institutions to recruit more minorities to cancer research. To raise the research capacity of MSIs, five years ago the CMBB launched the Minority Institution/Cancer Center Partnership (MI/CCP) program to develop and fund partnerships between major cancer research and training institutions and MSIs. Since its inception, 54 projects have been funded under various planning, partnership, and collaboration grants.
One example of a thriving MI/CCP partnership involves New Mexico State University (NMSU) in Las Cruces and the Fred Hutchinson Cancer Research Center in Seattle. Launched in June 2002 with a 5-year, $2.5 million planning grant, Hutchinson researchers developed a set of pilot projects - some focused on cancer in minority populations - and offered paid internships to NMSU minority students. In the fall of 2002, Nina Senutovich, an NMSU undergraduate hoping to pursue a career in immunology, joined the center's virology lab for a 10-week stint. "Initially I was nervous," she admits, "until I discovered that the people at Hutch are friendly and relaxed." At Hutchinson, Ms. Senutovich says, she developed "skills that will be useful for the rest of my career."
Events like last week's annual professional development and peer review workshop serve to bring together minority grant and supplement recipients with NCI and other researchers and CMBB staff. The workshop allows CURE grantees to learn about career development, gather information about funding opportunities, and develop an understanding of the intricacies of the different supplement and grant programs. Other opportunities bring together MI/CCP partners to collaborate on initiatives and develop research networks.
Dr. Springfield and CMBB staff, who include Ms. Bobby Rosenfeld, Dr. Hector Aguila, Dr. Peter Ogunbiyi, Ms. Belinda Locke, and Ms. LaShell Gaskins, are the first to admit that more still needs to be done. But they also note that many underrepresented minority scientists are successfully competing for NIH funding. "In turn," said Dr. Springfield, "these individuals are serving as role models for students from minority populations who, like them, want to dedicate their lives to helping others with a career in cancer research."
For details of all the grant and supplement programs available under CURE, go to http://minorityopportunities.nci.nih.gov/mTraining/index.html.
Familial Chordoma Study
Name of the Trial
Principal Investigators
Why Is This Study Important?
NCI is seeking families with two or more relatives with chordoma to participate in this study. Participants will complete a questionnaire, provide a blood sample, and undergo magnetic resonance imaging (MRI) scans.
"By studying these types of families, we've already mapped a gene to one chromosome that may be responsible for chordoma," said Dr. Parry. "Now we want to recruit more families with multiple cases of chordoma so we can narrow the region on the chromosome where this gene is located and determine whether or not other genes may be involved.
"Who Can Join This Study?
Where Is This Study Taking Place?
Who to Contact
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
NCI invites applications that are focused on research leading to the elucidation of mechanism(s) by which dietary factors influence epigenetic processes as well as increasing the understanding of these processes in cancer prevention. The objective is to encourage collaboration between nutrition and epigenetic experts to study bioactive food components with cancer preventive properties and to examine key epigenetic events in cancer processes so that investigators can begin to establish linkages between epigenetics, methylation pattern, and tumor incidence/behavior.
The PA will use the NIH Investigator-Initiated Research Project Grant (R01), the NIH Exploratory/Developmental Grant (R21), and the NIH Small Grants Program (R03) as award mechanisms.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2063
Inquiries: Dr. Sharon A. Ross, firstname.lastname@example.com
Characterization, Behavior, and Plasticity of Pluripotent Stem Cells
NCI, along with other branches of NIH, invites applications for studies on the characterization, behavior, and plasticity of human and nonhuman stem cells; regulation of their replication, differentiation, integration, and function in the nervous system; and identification and characterization of normal and tumor stem cells.
The PA will use the Exploratory/Developmental Grants (R21) mechanism and the Research Project (R01) grant mechanism.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2062
Inquiries: Dr. Neeraja Sathyamoorthy, firstname.lastname@example.com
Phased Application Awards in Cancer Prognosis and Prediction
This PA replaces PAR-03-098. NCI's Cancer Diagnosis Program invites applications for research projects to evaluate the utility and pilot the application of new strategies for determining prognosis or predicting response to therapy, thus providing tools to improve clinical decision-making in the care of cancer patients. This PA provides support for a first phase (R21) for technical development and a second phase (R33) for application and evaluation of clinical utility.
The PA will use the Exploratory/Developmental Research Grant Phase 2 (R33) and the combined R21/R33 Phased-Innovation Award mechanisms.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2060
Inquiries: Dr. Tracy G. Lugo, email@example.com; Dr. Magdalena Thurin, firstname.lastname@example.com; Dr. James V. Tricoli, email@example.com
Testing Tobacco Products Promoted To Reduce Harm
The purpose of this PA is to stimulate multidisciplinary research on potential reduced-exposure tobacco products, both smoked and smokeless, through the interplay of basic, biological, and behavioral research, surveillance, and epidemiology.
The PA will use the NIH Investigator-Initiated Research Project Grant (R01) and the Exploratory/Developmental Grant (R21) award mechanisms.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2061
Inquiries: Dr. Mirjana V. Djordjevic, email@example.com
Since its debut in January, the NCI Cancer Bulletin has provided its readers with a weekly snapshot of happenings in the cancer community - from research highlights to featured clinical trials and legislative updates. From now through May 27, you'll have the opportunity to tell us how we're doing by completing an online reader survey at http://www.cancerbulletin-survey.org.
By completing this short questionnaire, you'll help us to better meet the needs of our readers. Your feedback is vital in shaping future editions of the NCI Cancer Bulletin, an important tool in NCI's effort to disseminate information to the cancer community.
All survey responses are confidential and respondents can choose to answer or skip any questions in the survey. For more information, please contact Nina Goodman at firstname.lastname@example.com or at (301) 435-7789.
Conference to Address Health Outcomes Assessment
To register for the conference or view the program, go to http://www.Notesdiahome.org/docs/Events/events_search_detail.cfm?EventID=04015. For preliminary content and related information, go to http://www.outcomes.cancer.gov/conference/irt or contact Bryce Reeve at firstname.lastname@example.com.
NCI at ASCO
This is a list of selected scientific meetings sponsored by NCI and other organizations. For locations and times and a more complete list of scientific meetings, including NCI's weekly seminars and presentations open to the public, see the NCI Calendar of Scientific Meetings at http://calendar.cancer.gov.
NCI Exhibits


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In the spirit of the new year and resolutions galore, we're looking at interesting, healthy lunch box options. Add yours below:
Peanut butter and jelly gets boring. Nutella has been a great backup especially paired with some strawberries, but that gets old too. Regardless, both options will be in my pantry for busy mornings but I need some more interesting solutions.
Do you have any good lunch box ideas?
I asked around and some other moms shared their tips with me.
Elise S., mom of two, told me how she brightens up peanut butter and jelly or tuna sandwiches with a little trick. "I sometimes cut them into different shapes with cookie cutters or use a little gadget that cuts the sandwich into a circle with no crusts."
Kids love the "no crust" sandwiches but did you know that crust may be the healthiest part of the bread? Check this article out.
My sister, Jackie B., saw a tip on television for salad lovers that she shared with me. "Make a salad in a Ziploc bag for ease. Kids dump in dressing, close bag and shake. Open, fold down top, and dig in. The whole thing can be thrown away. That is a mommy time saver (hate to have to clean out dirty lunch bags at night)."
Of course, you can use reusable containers that kids can shake too. That would be better for the environment but moms will endure the "cleaning up" which can be horrific, especially if the containers are left in book bags on a Friday night! Wish there was a green way to avoid the clean up without using plastic bags.
Maryellen R., a mom of teenagers, needs to be creative because her girls don't eat meat. She sends hummus and pita or pretzel chips many days. One of her girls likes "cold roasted veggie wraps with roasted zucchini, yellow squash and roasted red peppers with a little bit of Italian dressing on them." That sounds yummy!
Maryellen's other daughter enjoys "cold quesadillas with salsa to dip." She also sends pasta salads with white beans or chick peas and Italian dressing and includes cut up cucumbers and tomatoes. When her girls were younger, they did eat meat but her youngest, Tess, didn't like sandwiches so Maryellen would pack a couple of cheese sticks and some pepperoni slices. Tess became known as "Tesseroni " with her lunch bunch.
Danielle D., a friend who lives in Florida with two children (already back in school), gave me some great ideas for lunches that make you think a little outside the lunchbox. "My oldest loves burritos and doesn't mind eating them cold, we put heated black beans, rice and chicken in a warmed tortilla and wrap it in foil, sometimes it is warm and sometimes it isn't but she is happy with that. They both like tacos the same way, just heat up the meat and tortilla, wrap it and send lettuce, salsa and sour cream in a small container." Another idea she told me about was a cold chicken wrap with Caesar dressing. She wraps leftover chicken or those Perdue short cuts in a tortilla with hearts of romaine, a little shredded cheese, and Caesar dressing. That sounds delicious, I think I'd like that in my own lunch box.
Bento Boxes
I've been reading about these bento box lunches. Have you heard about them?
They are a Japanese packed lunch that usually includes rice or pasta, some protein, and fruits and vegetables. The bento lunch is becoming increasingly popular in the United States. Basically, they are reusable containers with different sections or smaller containers inside to keep food separate, fresh, and pleasing to the eye.
They make sense.
Food doesn't get thrown around like it does in a traditional styled lunch box when your child runs to the bus stop, hops on the bus, and drags their bag along the floor. Everything stays safe in its own spot. Giggle.com has a Double Decker Mealbox for $10 and you can check out some bento ideas at Parenting.com. Also visit Fit Fresh; Lunch In a Box; and Laptop Lunches for great ways to pack a good bento box lunch.
Thermos Lunches
Several moms mentioned thermos lunches. Some favorite thermos fillers included Spaghettios, various soups, macaroni and cheese, and leftovers. Most moms complained that they are not sure how hot the food stays and I have found that to be a problem as well. My kids have come home with a full thermos telling me the macaroni and cheese was cold and mushed together. So, this year I plan to invest in a good thermos. I'm thinking L.L. Bean or REI may have some well-insulated camping thermoses.
My Tips
Think creatively when planning lunches. Try some wraps, shaken salads or bento boxes. Veggies and dip are always a great hit and they sell individual packs of dip just for this purpose. Apple slices with peanut butter are also a favorite and again, they sell individual packs of peanut butter and even individual packs of apple slices to make our jobs a little easier. Frozen Go-Gurts are a delicious secret. They are yummy when frozen and will defrost a bit before lunch. They can get messy so be sure to send napkins. Grape tomatoes, grapes, bananas, and any kind of fruit or raw vegetable are the perfect addition to a healthy lunch. Cheese sticks and whole grain crackers are a great go to item for the lunch box.
My girls love homemade chicken noodle soup so this year my plan is to buy a rotisserie chicken every couple of weeks, make soup and use the rest of the chicken for sandwiches. I figure this will be healthy, not loads of work, and easy on the pocketbook. I will multitask my rotisserie chicken.
Water is our beverage of choice but 100 percent juice boxes and milk that don't need to be refrigerated provide necessary vitamins and minerals. Follow the USDA's Nutritional Guidelines to pack health into your kid's lunch boxes. They will feel better and perform better when filled with the right kinds of food.
Don't forget about a good night's sleep and a hearty breakfast each day. Breakfast, as we all know, is the most important meal of the day. Start them off right and get them through the day with fun and nutrition filled lunch boxes. Start planning now and pack a lunch with a big punch!
A version of this ran in 2012.

subset: commoncrawl


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November 2013 – February 2014
When: Monday, March 4th, 2013
Where: New Haven County Credit Union
450 Universal Drive
North Haven, Ct 06473
Agenda: 5:30 – Pizza and soft drinks available
5:45 – Brief Meeting and Election of Officers
(There will be no program, and the meeting should not run more
than 30 minutes.)
**** If anyone is interested in a position, please let Jim know. ****
Cost: No Cost to attend!
Please call Jim Howard to let him know you will attend
@ 203-234-8773 x 109, or email him at email@example.com,
so that he knows how many pizzas to order!
He will be ordering the pizza at four, so please
make sure you call beforehand!
Credit unions promote the economic well being of their members, especially those of modest means, through a system that is member-owned, volunteer-directed and not-for-profit.
The credit union mission has always been to ensure secure financial choices at lower costs for their members. That's why credit unions offer financial products that provide better returns on savings, reduced rates on loans and lower or no fees on services.
While credit unions are regulated by the federal and state governments, they are also governed by volunteer boards elected by their membership. Credit unions don't answer to stockholders, but to each of their 96 million members.
Credit unions invest in people by helping those who have been traditionally underserved by banks. Groups like seniors on fixed incomes, single working moms, minority communities needing greater community investment, and small business owners struggling to raise capital all rely on credit unions for important financial services at reasonable costs.
While the big banks have abandoned small businesses in droves because they just can't make enough money, credit unions promote their small business members in a struggling economy by providing low cost credit alternatives. This credit union investment means millions of jobs across America.
Unfortunately, the big banks and some in Congress want to raise taxes and impose new fees on 96 million credit union members who represent 40% of all Americans, yet represent only 6% of the assets in financial institutions. And, they want to do this despite the fact that credit unions are not-for-profit and meeting their core mission every day.
That's wrong and will imperil the credit union movement that so many have come to depend on for real financial choice.
Don't let Congress raise taxes on 96 million credit union members. Don't let Congress eliminate real financial choice. Don't let Congress destroy our credit unions.
To learn even more about credit unions in your community, or join a credit union please visit http://www.asmarterchoice.org/.
Annual Holiday Meeting! POSTPONED DUE TO WEATHER- NEW DATE AND TIME!
Please let us know if you can make it to the event tomorrow by emailing Barbara Thorpe, firstname.lastname@example.com with your meal plan and confirmation of the new date and time! Thanks


text:
The Centers for Disease Control and Prevention are warning Massachusetts residents of potentially contaminated ricotta salata cheesesold in the state.
Forever Cheese Inc. voluntarily recalled one lot of Frescolina brand ricotta salata cheese because of Listeria monocytogenes contamination.
The recall affects more than a dozen states, including Massachusetts. The recalled cheese was sold to distributors for retailers and restaurants between June 20 and Aug. 9. The CDC has not reported the exact locations of the sales or companies that may have sold the cheese.
"The recall affects lot number T9425 and/or production code 441202. Products were sold to supermarkets, restaurants and wholesale distributors," according to the CDC.
The CDC offered the following information to consumers:
Contaminated ricotta salata cheese has made people sick.
- CDC recommends that consumers not eat imported Frescolina brand ricotta salata cheese. This is especially important for pregnant women, persons with weakened immune systems, and older adults.
- Even if some of the cheese has been eaten without anyone becoming ill, the rest of the cheese should be disposed of immediately.
- When in doubt, throw it out. (See disposal recommendations below)
How do I recognize the contaminated cheese?
- The recalled cheese is labeled Frescolina brand ricotta salata cheese. It is a product of Italy. Consumers should consult with their retailer if they have questions about the origin of cheese.
- Be aware that the recalled cheese has a 4 month shelf life, so contaminated cheese may still be in consumer's refrigerators and may still be for sale in stores.
- Ricotta salata cheese is often served crumbled or grated as an ingredient in some dishes.
- Ricotta salata is a salty white cheese made from pasteurized sheep's milk. Note: It is not the same as ricotta cheese, which is a very soft cheese often sold in plastic tubs.
Contaminated cheese may still be in consumers' homes.
Listeria can grow in cut cheese at room and refrigerator temperatures. Listeria can also spread to other cheeses cut and served on the same cutting board or stored in the same area.
- Follow these simple steps if recalled cheese is or was in your home:
- Dispose of cheese in a closed plastic bag placed in a sealed trash can. This will prevent people and animals from eating it.
- Wash the cheese drawer and other areas where the cheese was stored in the refrigerator with hot water and soap. Sanitize the area with a solution of one tablespoon of chlorine bleach to one gallon of hot water.
- Wash cutting boards, surfaces, and utensils used to cut, serve, or store cheese. If possible, use a dishwasher; otherwise, use hot water and soap, followed by sanitizing with a dilute bleach solution described above.
- Wash hands with warm water and soap following the cleaning and sanitation process.
Who is most at risk?
- Listeriosis primarily affects pregnant women and their newborn infants, persons with weakened immune systems, and older adults.
- Persons who think they might have become ill from eating contaminated cheese should consult their doctor immediately. People can sometimes develop listeriosis even up to two months after eating contaminated food.


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Suzu Wakana is a hot and horny Asian teen! She is in her tennis clothes when her guy comes into the room and they are making out. She gets her nice tits felt up and squeezed before he attends to her white panties and fingers her pussy underneath them. Soon the crotch is ripped and he is inserting his cock in to her wet pussy and giving her a hard fucking before she goes off to play her game!
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Round tit and horny babe Yuria Satomi making out and hardcore fucked. She tease and makes out with her hung lover and strips down on her sexy dress. She get her boobies squuezed and wet pussy licked. She humps on his cock, grinds on it ti..
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Sensual Asian beauty Yuki Kami enjoys stimulating her horny guy while in the bath with a naughty and deep oral session. She gently grabs his cock after letting the guy play with her pussy and kneels, starting to suck it like crazy and have intense pleasure while moaning. Hot Asian models gives amazing cum swallowing scene
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Take a look at our excited and hot MILF Saki Kouzai, who is about to start stunning and non-stop toy insertion session. It seems like our filthy babe knows how to use a vibrator in her hot milf pussy with deep strokes while being watched in this cosplay action.
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Hot MILF Karou Natsuki invites her naughty girlfriend Maki Hokujo to get involved together in a really nasty group action inside the bath, where they can enjoy cock sucking and pussy licking with their might and passionate lesbian partner till they cum.
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Superb Japanese beauty amazes with her sexy solo show by gently rubbing her fatty pussy while bouncing and pinching those fine boobs. Adorable babe loves rubbing it hard and moaning in pleasure in one nasty hardcore solo masturbation scene ending in orgasm!
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Enjoy this naughty Japanese angel having her hairy twat ravaged in a staggering hardcore action. It all started with a big of finger fucking, cutie moaning pretty hard while feeling his fingers up the hole, begging him to slam his dick all over her cunt until she reaches orgasm
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The Cuyahoga County Jail has suspected serial killer Michael Madison under a special watch 24/7.
It's the same way the jail is holding Ariel Castro - the man accused of holding three women hostage for years.
Jailers are holding Madison in the same kind of cell as Castro, and under many of the same conditions.
Madison is under 24/7 surveillance. The jail says there is no indication Madison might try to kill himself, but guards want to look out for any problems. They are also concerned about his safety and the safety of other inmates.
19 Action News has seen this go on for months with Castro. And the jail says it did the same thing with convicted serial killer Anthony Sowell.
Madison also has other restrictions. For instance, no visitors.
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Fun ways to stay active this fall
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Chat with Peyton List (and win a signed issue) this Thursday!
Disney Channel's Make Your Mark: Mallory Kievman
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GL Tweets !
1 HOURS AGO Setting the alarm to wake up for school tomorrow *crying a little inside*
2 HOURS AGO BTS shopping already done? We know a true fashionista is never REALLY done shopping, especially for fall!: http://t.co/aoMznFbTBq
3 HOURS AGO Favorite if you put off your homework until last minute on sunday! #Procrastinator #AndIllDoItAgain
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Anna Chlumsky, Whitney Port, Valorie Curry, Sammi Hanratty and Viva Luxury's Annabelle Fleur and other Celebrities Attend the Cynthia Rowley Spring 2015 Presentation
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If your toilet grosses you out...you may want to not read this article...it's amazing how many everyday things are dirtier than the throne!
Your Handbag A new study has proven that your handbag accumulates more bacteria than your average toilet seat. That's probably because you throw it on the floor no matter where you are.
Your Cell Phone Yup, that thing that you touch every other minute and constantly put against your cheek holds a TON of bacteria. Like, a lot. Gross.
Ice Cubes You might think that frozen water is relatively safe from bacteria, but think again - a study found that more than 70 percent of the ice used in restaurants was dirtier than the toilet water. This stuff goes in YOUR MOUTH. Gross.
Your Computer Keyboard You touch your keyboard every single day, but have you ever thought about how it could maybe be making you sick? Probably not. One expert says that keyboards have 5 times more germs than toilets.
A Remote Control Who knows whose hands have been on this thing? All I know is, you might want to start washing your hands after a good TV sesh.
A Door Handle This one might seem pretty obvious, but still. It's tough to stop yourself from touching a door handle. It's also tough to remember to clean your hands every time after you touch one.
The Kitchen Sink You would think a sink, where things go to get clean, would be relatively free of bacteria, right? Nope. This report says they're dirtier than your entire bathroom.
The Kitchen Counter Think twice before you eat your food over there.


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Many of you expressed disgust when you found out that fish and eggs were added to microwave popcorn. The brand I bought was Act Movie Theater Popcorn. My kids wanted it, so that's what I got. It's kind of funny, because whenever their friends come over, they push popcorn on them so we can use it up.
Tuesday, February 27, 2007
Freshly Baked Seeded Light Rye Bread
Many of you expressed disgust when you found out that fish and eggs were added to microwave popcorn. The brand I bought was Act Movie Theater Popcorn. My kids wanted it, so that's what I got. It's kind of funny, because whenever their friends come over, they push popcorn on them so we can use it up.
18 comments:
Yum, your rye bread looks delicious! I've never tried putting wheat gluten in my bread but it sounds like a good idea, because sometimes it is hard to slice as thin as I would like it. How much do you use in proportion with the other flour?ReplyDelete
Lovin' the rye bread. A Jewish staple... soooooooooooooo nice to see it sans the other usuals (corned beef, tongue, Reuben stuff). (YIKES!) Fresh bread can't be beat, Melody. I swoon at the scent! Thanks for the head's up on the popcorn. Frightening. Can you imagine "the old days" when manufacturer's didn't put ingredients on their labels? Knowledge = power.ReplyDelete
that just looks heavenly...can you post the recipe?ReplyDelete
Your bread looks wonderful. If you can share your recipe that would be great. When I read your post on the popcorn I was sickened. I don't use the microwaive often, if fact it is in our garage, so I make popcorn with an airpopper or the old fashioned way. Before I was vegan I bet I tried that brand. Sick!!!!ReplyDelete
I am NOT a fan of Dark rye bread either.. I definitely like mine light .. yours looks awesome..ReplyDelete
We pop our own microwave popcorn around here.. a brown lunch bag and about a 1/3 cup kernels then some earth balance and nutritional yeast flakes = yummo!
Melody bread looks delicious!ReplyDelete
Respose to the comment you left on my blog:(Not related to this post)
I have never tried cooking with stevia but if you have already used it and were successful with preparing syrup I would think you should be able to substitute sugar with stevia in the halwa recipe.
i came to know of your site today thro megan the vegan
you write wonderfully!!!!
there is lots of warmth in your writing.
In india we do not practise vegan there is a lot of vegeterianism but not vegan as such products are not available here.
i read a lot of vegan thro blogs and like what i read
so keep up your good work
Home made bread, yum! I haven't made any in awhile. Perhaps I will do so in a few weeks when I am done traveling.ReplyDelete
That pasta picture from a few weeks back is really beautiful.
I stopped buying store bought popcorn when I found out that the butter flavor often causes the workers in the factory to have breathing problems.
Fish and eggs as an additive is yet another reason I will pop my own. That is just odd!
- Heather5:59 AM
Hello all! The bread looks wonderful!! I am a long time homemade bread baker but have recently hit a snag. I think I came to this blog a lttle late, but perhaps you all will have some ideas for me anyway....ReplyDelete
I recently found out that all of my lovely bread is making me sick! Turns out I am allergic to wheat and wheat gluten. I like my bread soft and yummy (kind of a comfort food, you know?), so the alternatives are not cutting it. Any ideas or suggestions for me?
Thank you in advance and I am really looking forward to digging further into your site! I love what I've seen so far!!


text: Rockford Fosgate R2D4-10 Prime R2 Series 10" subwoofer with dual 4-ohm voice coils Zoom Front Back Photos Videos My vehicle's homepage We don't check this item for fit or compatibility. Item #: 575R2D410 Review Summary 6 people say In Stock $74.99 Was: -$5.00 : Price Break Free Crutchfield lifetime tech support Free Shipping Your price $69.99 Add to cart + Add to wishlist Email me alerts for this product Buy this item and earn up to 70 Rewards points See more offers and ways to save Special Financing Available x By buying this product you'll earn up to 70 Rewards points. When you sign up for a Crutchfield account, you'll be enrolled in Crutchfield Rewards. You'll earn one point for every dollar you spend on gear from us. You can turn your points into Rewards Cards that you can use toward future purchases. You can sign up for an account now, or after you complete your purchase (you'll get credit for the points either way). Sign up for a Crutchfield account Overview Details Customer Reviews Q&A Articles & Videos Accessories Our take on the Rockford Fosgate R2D4-10 by Jo Greene What's a component sub and why would I want one? A component sub is simply a speaker that's designed to reproduce bass once it's installed in a compatible enclosure. Think about the impact of a movie soundtrack in a big theater or even in your own home HDTV setup. A component sub can add the same kind of power to the music in your car. And a car sub is not all about the boom that you hear on a street corner (although that's cool too) - you can pair a component sub with your choice of enclosure to get bass just the way you like it, from tight and punchy to fat and loose. And once you experience music in your car with a well-tuned subwoofer, you'll never go back. Rockford Fosgate's Prime R2 subs deliver strong bass in your car, and they are definitely built to last. The R2D4-10 sub features a 10" mica-injected polypropylene cone that works with a high-density poly-foam surround to punch out fat, deep notes. Rockford Fosgate stitches the tinsel leads that carry the signal to the voice coils directly into the cone — they'll hang tough through heavy use so you get consistent, reliable performance. The stamped solid-steel frame offers venting usually found in high-end subs that keeps this sub running cool. Dual 4-ohm voice coils allow you to wire this sub for 2- or 8-ohm impedance, giving you more flexibility in setting up your system. Rockford Fosgate optimizes this Prime sub for both sealed and ported enclosures so you can choose the type of bass you want in your ride. To drive this single subwoofer, we recommend a mono amplifier rated between 200 and 375 watts RMS at 2 ohms. For more information, please refer to our article on How to Match Subwoofers and Amplifiers. See more info on this item Highlights:10" subwoofer with dual 4-ohm voice coilsmica-injected polypropylene woofer cone with poly-foam surroundstamped solid-steel framepower range: 50-250 watts RMS (500 watts peak power)frequency response: 45-250sensitivity: 87 dBtop-mount depth: 4-3/8"sealed box volume: 0.59 cubic feetported box volume: 1.4 cubic feetwarranty: 1 yearOur 60-day money-back guarantee Hands-on research from the Crutchfield Labs (what are the Labs?) Features and specs chart | What's in the box? | In-depth notes Features and Specs Size Loading... 10 -inch Impedance Loading... 4 ohms Cone Material Loading... Mica injected poly Surround Material Loading... Poly-foam Ideal Sealed Box Volume (cubic feet) Loading... 0.59 Ideal Ported Box Volume (cubic feet) Loading... 1.4 Port diameter (inches) Loading... 4 Port length (inches) Loading... 13 Free-Air Loading... No Dual Voice Coil Loading... Yes Sensitivity Loading... 87 dB at 1 watt Frequency Response Loading... 45 - 250 Hz RMS Power Range (Watts) Loading... 50-250 Peak Power Handling (Watts) Loading... 500 Top Mount Depth (inches) Loading... 4 7/16 Bottom Mount Depth (inches) Loading... N/A Cutout Diameter or Length (inches) Loading... 9 1/16 Vas (liters) Loading... 39 Fs (Hz) Loading... 35 Qts Loading... 0.53 Xmax (millimeters) Loading... 6.5 Parts Warranty Loading... 1 Year Labor Warranty Loading... 1 Year Product Research What's in the box? Download owner's manual 10" Dual 4-ohm voice coil subwoofer Eight 1-1/8" Allen head screws 4mm Allen head bit Installation/Operation manual (English/ French/ Spanish/ German) Our Product Research Team At Crutchfield, you'll get detailed, accurate information that's hard to find elsewhere. That's because we have our own in-house Product Research team — they open the box, verify contents, check the owner's manual, and record dimensions, features and specs. We stay on top of new products and technologies to help people make informed choices. Features Enclosure Compatibility Features Overview: The Rockford Fosgate Prime R2D4-10 is a 10-inch subwoofer with dual 4Ω voice coils. The sub features a StampCast steel frame, quick-release compression terminals, and a mica injected polypropylene cone. An anodized aluminum voice coil former and spider venting help keep the subwoofer cool. Steel Basket: The R2D4-10 subwoofer features a StampCast steel basket for added rigidity. Compression Terminals: The Prime R2D4-10 features spring post terminals which accommodate speaker wire up to 12 gauge. CEA-2031 Compliant: Power handling on the Rockford Fosgate Prime R2D4-10 subwoofer conforms to CEA-2031 industry standards. This means the subwoofer has the capacity to handle power under continuous demand, not instantaneous power handling, that over time, can damage voice coils. Enclosure Compatibility Sealed Box: Rockford recommends a sealed enclosure with an optimum internal volume of 0.59 cubic feet (from 0.5 to 0.75 cubic feet is acceptable). Sealed enclosures provide the most control over a woofer, will handle a lot of power, and provide accurate sonic reproduction, making them suitable to all types of music. Ported Box: Rockford recommends a ported enclosure with an internal volume of 1.4 cubic feet using one 4" diameter x 13" long port; this yields a tuning frequency of 43 Hz. Ported (or vented) enclosures typically provide better overall efficiency than sealed so they are suitable for use with smaller amplifiers, giving you more bass output from less power. However, this efficiency comes at the expense of very low frequency output (below 40Hz). Review this product Submit a review and then enter to win a $500 rewards card Rockford Fosgate R2D4-10 Reviews Average Customer Review: 6 people say: Review this product: Thanks for taking the time to share your experiences about this product. Please be sure to focus your comments on the product itself. Read our Review Guidelines for more information. Review title * Email Your email won't be visible. Please use the email address that is associated with your order. Display name (e.g., JohnD) Your review will be signed using the display name and location * Your location (e.g., Charlottesville, VA) * Your rating Click on a star to rate the overall product on a scale of 1-5 Rate the following specific attributes Value Sound Quality Ease of Use "Coolness Factor" Build Quality 1500 characters left * Your review Attach a YouTube Review Crutchfield Video Review Guidelines Only submit videos that you made or are authorized to use. Do not submit videos that contain music, video or visuals that are copyrighted and belong to someone else. Please see our Review Guidelines for more information. Submit the URL of your YouTube™ video review or product demonstration. e.g., "http://www.youtube.com/v/o79TWHh598U" 500 characters left Pros 500 characters left Cons * Agree to Terms By checking this box you agree your review becomes the property of Crutchfield, that you are over 18 years of age, that you own or have owned this product, and that you are located within the United States or its territories. Please see our Review Guidelines for more information. We reserve the right (but are not obligated to) review all submissions and edit or remove any review in any manner which we deem necessary. Your review should be posted within seven days. Filter by rating: 5 Star: (0) 4 Star: (0) 3 Star: (0) 2 Star: (0) 1 Star: (0) 5 out of 5 Great little sub Written By Anonymous, Elkview wv on Friday, September 19, 2014 Sounds Very well with a punch 300.1 behind it. Mostly listen to rock now. Does really well Was this review helpful? Yes | No "Coolness Factor" Build Quality Ease of Use Sound Quality Value 4 out of 5 Rockford Fosgate R2D4-10 Written By Anonymous, Windsor, On on Friday, April 04, 2014 Crutchfield Customer Review (What's this?) Good bang for your buck Was this review helpful? Yes | No "Coolness Factor" Build Quality Ease of Use Sound Quality Value 5 out of 5 Rockford Fosgate R@D$-10 Written By Stacy, Anna, IL on Wednesday, March 05, 2014 Crutchfield Customer Review (What's this?) Whats to say? You can't go wrong with Fosgate subs, wheither you buy inexpensive ones or the high dollar ones you can't beat them. 2 10"s in a 4 door jeep are plenty loud!!! Pros: Works perfectly with my old Fosgate punch 100 Amp! Cons: Thow in free grill covers, not everyone installs in a trunk of a car! Was this review helpful? Yes | No "Coolness Factor" Build Quality Ease of Use Sound Quality Value 4 out of 5 rockford fosgate r2d4-10 Written By fob, zuni new mexico on Tuesday, July 30, 2013 Crutchfield Customer Review (What's this?) ths subwoofer rocks Pros: like the contruction Cons: none Was this review helpful? Yes | No "Coolness Factor" Build Quality Ease of Use Sound Quality Value 5 out of 5 pleased Written By KR, Brigham City,UT on Wednesday, June 19, 2013 Crutchfield Customer Review (What's this?) I have been impressed with its sound and versatile independence Pros: sounds great even at low volume Cons: haven't found any yet Was this review helpful? Yes | No "Coolness Factor" Build Quality Ease of Use Sound Quality Value 5 out of 5 rockford sub Written By rick, mason, ohio on Thursday, February 02, 2012 Crutchfield Customer Review (What's this?) great little sub for the price ..... Pros: great bass, good looks Cons: speaker grill does not fit, 3 out of 4 people found this helpful Was this review helpful? Yes | No "Coolness Factor" Build Quality Ease of Use Sound Quality Value 1 question already asked How to set up 2 of these subs with an alpine m500 amp. Wiring ? [ Eric Oram Jul 03, 2014 ] 2 answers try this link. http://www.crutchfield.com/S-I6MUq4yYgxX/learn/learningcenter/car/subwoofers_wiring.html [ PATRICK Jul 06, 2014 ] Each speaker has two four ohm coils in it, so you need to wire each speaker in series (positive to negative) then the two speakers in parallel from the amp (positive to positive : negative to negative) The math works out to a 4 ohm load. [ TIMOTHY Jul 03, 2014 ] Add accessories for the Rockford Fosgate R2D4-10 Add Accessories Add a Warranty We've verified that these enclosures are a good match for this subwoofer. See all categories & accessories We've verified that these enclosures are a good match for this subwoofer. Empty Enclosures It's critical to have good wire, and none is included with the sub. Speaker Wire Reduce ambient road noise and your vehicle's "rattles," for better sound inside your car. Sound Deadening Add a grille and keep your sub safe. Subwoofer Grilles These can be useful if you are building a custom box. Build Your Own Subwoofer Box Other Car Stereo Accessories Sound Ordnance Bass Bunker Sealed single 10" subwoofer enclosure (Model BB10-50S) 16 people say Your Price: $59.99 Add to Cart Sound Ordnance Bass Bunker Ported single 10" subwoofer enclosure (Model BB10-125V) 9 people say Your Price: $79.99 Add to Cart Sound Ordnance Bass Bunker Ported dual 10" subwoofer enclosure (Model BB102-125V) 28 people say Your Price: $79.99 Add to Cart T-Spec 16-gauge Speaker Wire Black/white jacket priced per foot 12 people say Your Price: $0.69 Add to Cart T-Spec 12-gauge Speaker Wire Black/white jacket priced per foot 27 people say Your Price: $1.99 Add to Cart Stinger PRO Series 16-gauge Speaker Wire Black jacket priced per foot 46 people say Your Price: $0.39 Add to Cart Dynamat Xtreme Wedge Pack 1 sheet, 4 square feet 6 people say Your Price: $39.99 Add to Cart Dynamat SuperLite Tri-Pak Triple package 3 sheets, 12 square feet (Model #10612) 17 people say Your Price: $69.99 Add to Cart Dynamat 19100 License Frame Kit 15 people say Your Price: $14.99 Add to Cart Dynamat Xtreme Trunk Kit 5 sheets, 20 square feet 12 people say Your Price: $169.99 Add to Cart Dynamat Dynaliner One 54" x 32" sheet (1/8" thick) 6 people say Your Price: $69.99 Add to Cart Speaker Grilles (10" waffle style) 42 people say Your Price: $9.99 Add to Cart Metra Box Carpet Carpet roll (54" x 5 yards) available in 3 colors (Black) Options Black-$39.99 Charcoal-$39.99 Silver-$39.99 Carpet roll (54" x 5 yards) available in 3 colors (Black) Carpet roll (54" x 5 yards) available in 3 colors (Charcoal) Carpet roll (54" x 5 yards) available in 3 colors (Silver) 24 people say Your Price: $39.99 Add to Cart Polyester Fiber Stuffing Make your subwoofer think it's in a bigger box (1-pound pack) 34 people say Your Price: $12.99 Add to Cart Metra Speaker Terminal Round terminal cup with binding post connectors (for do-it-yourself box builders) 13 people say Your Price: $9.99 Add to Cart Corner Protectors 5 people say Your Price: $9.99 Add to Cart Rubber Feet 4 people say Your Price: $5.99 Add to Cart Metra Speaker Terminal Round terminal cup with spring clip connectors (for do-it-yourself box builders) 6 people say Your Price: $3.99 Add to Cart Metra Speaker Terminal Square terminal cup with binding post connectors (for do-it-yourself box builders) 7 people say Your Price: $9.99 Add to Cart Grille Clamps (Front/top mount clamps) 15 people say Your Price: $3.99 Add to Cart Metra Speaker Terminal Square terminal cup with spring clip connectors (for do-it-yourself box builders) 7 people say Your Price: $3.99 Add to Cart Springback Handle 2 people say Your Price: $9.99 Add to Cart Port Tube 4" diameter, 4-1/2" long 1 person says Your Price: $5.99 Add to Cart Autosound 2000 CD Set 5 Test CDs Your Price: $69.95After $10.00 Price Break Add to Cart Why choose SquareTrade? The #1-Rated Protection Plan Thousands of people have reviewed SquareTrade Protection Plans — and made us #1. 5-Day Service Guarantee & Free Shipping We'll repair or replace your item in five business days or less after we've received it, or your plan is free. And, as always, we pay for all shipping. Protection from Normal, Everyday Use Repairing your average mechanical or electrical failure can cost as much as buying a new device. With SquareTrade, you're covered — including parts and labor. 3 Year Protection Plan Your Price: $10.99 Add to Cart For a more in-depth review and enhanced detailed information on the Rockford Fosgate R2D4-10, please visit the Crutchfield website product page (/ISEO-rccbcspd/p_575R2D410/Rockford-Fosgate-R2D4-10.html ). × Front Back Searches related to the Rockford Fosgate R2D4-10 Prime R2 Series 10" subwoofer with dual 4-ohm voice coils Rockford Fosgate Rockford Fosgate Component Subwoofers Rockford Fosgate sale Component Subwoofers sale Rockford Fosgate R2D4-10 reviews Rockford Fosgate R2D4-10 vs JL Audio 10W0v3-4 Rockford Fosgate R2D4-10 vs Kicker 10C104 Rockford Fosgate R2D4-10 vs Kicker 40CWRT672


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Commentary & Feedback on Draft II of the Next Generation Science Standards
Paul Gross
Douglas Buttrey
Ursula Goodenough
Noretta Koertge
Lawrence S. Lerner
Martha Schwartz
Richard Schwartz
William H. Schmidt
W. Stephen Wilson
February 04, 2013
The Thomas B. Fordham Institute has provided big-picture feedback and detailed, standard-specific commentary for the second draft of the Next Generation Science Standards—standards that done right, set a firm foundation upon which the rest of science education across the states will be constructed...
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2011-12 Ohio Report Card Analysis
Aaron Churchill
December 19, 2012
Fordham's annual analysis of school academic performance relies on the Ohio Department of Education's 2011-12 preliminary Report Card data as well as other ODE data sources. Our analysis of Ohio's public schools (district and charter) answers the following questions (among others): How many...
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Commentary & Feedback on Draft I of the Next Generation Science Standards
Paul Gross
Lawrence S. Lerner
John Lynch
Martha Schwartz
Richard Schwartz
W. Stephen Wilson
June 20, 2012
In May, Achieve unveiled and solicited comments on the first draft of the Next Generation Science Standards, the product of months of work by a team of writers on behalf of twenty-six states. This review by Fordham provides commentary, feedback, and constructive advice that we hope the NGSS authors...
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Putting a Price Tag on the Common Core: How Much Will Smart Implementation Cost?
Patrick J. Murphy
Elliot Regenstein
May 24, 2012
The Common Core State Standards (CCSS) for English language arts and mathematics represent a sea change in standards-based reform and their implementation is the movement's next—and greatest—challenge. Yet, while most states have now set forth implementation plans, these tomes seldom address the...
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Future Shock: Early Common Core implementation lessons from Ohio
May 18, 2012
The Thomas B. Fordham Institute has long advocated for high quality academic content standards nationally- and in our home state of Ohio. The Buckeye State committed itself to adopting more rigorous academic content standards in 2010: Ohio is one of 45 states and the District of Columbia that has...
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Review of Draft Texas Mathematics Standards 2012
W. Stephen Wilson
April 17, 2012
In April 2012, Texas adopted new math standards. Fordham reviewed the draft standards and found them to be a modest improvement. But not by much, and they remain inferior to the Common Core math standards. This review, by W. Stephen Wilson, supplements our 2010 report, The State of State Standards—...
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Defining Strong State Accountability Systems: How Can Better Standards Gain Greater Traction?
Eileen Reed
Janie Scull
Gerilyn Slicker
Amber M. Northern, Ph.D.
April 02, 2012
Rigorous standards and aligned assessments are vital tools for boosting education outcomes but they have little traction without strong accountability systems that attach consequences to performance. In this pilot study, Eileen Reed, Janie Scull, Gerilyn Slicker, and Amber Winkler lay out the...
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The State of State Science Standards 2012
January 30, 2012
American science performance is lagging as the economy becomes increasingly high tech, but our current science standards are doing little to solve the problem. Reviewers evaluated science standards for every state for this report and their findings were deeply troubling: The majority of states...
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The Accountability Plateau
Mark Schneider
December 28, 2011
After more than ten years under NCLB, that law's legacy continues to be fiercely contested. This analysis of NAEP scores—focusing on Texas and on the entire nation—by former NCES commissioner Mark Schneider finds that solid gains in math achievement coincided with the advent of "consequential...
The World's Least Efficient Schools
Chester E. Finn, Jr.
Herbert J. Walberg
December 07, 2011
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Series: Evolution Basics (48 entries)
Written by BioLogos Fellow of Biology Dennis Venema, this series of posts is intended as a basic introduction to the science of evolution for non-specialists.
Origins News Roundup for August 6, 2014
News about the Ebola outbreak and initiatives in genomic medicine lead our news roundup this week, with a collection of research and learning opportunities in biology and at the science/faith border to follow.
Origins News Round-Up for May 28, 2014
This weeks in Origins news: studies of a skeleton uncovered in 2007 provide clues about rapid human evolution in the Americas, our climate and Christian stewardship, a few BioLogos folks give interviews, and some cool links to miscellaneous finds.
Human Evolution: Genes, Genealogies and Phylogenies
When read in this way, the Genesis stories may be seen as one of the greatest-ever revolutions in human understanding. Genesis used the literary forms of the day to introduce its readers to a rational God who cares for people – and whose faithfulness made science possible. Genesis is expressly about theology, not science.
Origins News Roundup for May 14, 2014
This week in our Origins News Roundup: News of new nucleobases, the future of synthetic biology, and some healthy dialogue and critique of certain aspects of modern science.
Series: Intelligent Design and Common Ancestry (4 entries)
Would those genuinely interested in learning about evolution benefit from a careful explanation of why these common objections don't hold water? Here the answer seemed to me to be "yes."
"The Language of God" Book Club–Chapter 5
Does Collins show that Evangelicals have turned the corner on the scandal Noll brought to light, or does the continued resistance of the majority of Evangelicals to Collins's work (about 75% reject human evolution) show that we as a collective group still do not take the life of the mind seriously?
Origins News Round-up for January 17, 2014
Today's Origins News Roundup features challenging and exciting new ideas about evolutionary theory, fossil finds that add to our understanding of how carnivores and humans developed, some interesting science history from England, and more on American views of evolution.
Origins News Round-up for December 6, 2013
This week's Origins News Roundup features highlights from a recent conference of evangelical theologians, exciting human fossil finds, tell-tale lice, and a few words from the Pope.
Origins News Roundup for November 1, 2013
Where is human evolution going? Where has human evolution been? A roundup of stories from the past few weeks.
Series: The Evolutionary Origins of Genetic Information (4 entries)
Join astrobiologist Stephen Freeland for a look into the nature of information and the origins of life on earth. (These posts were originally published as a paper in the ASAs academic journal, PSCF, and are reprinted here with permission.)
Biological Evolution: What Makes it Good Science? Part 2
The Galápagos Islands were not a distinct "center of creation," but a workshop for evolution in which an ancestral species made it to the yet uncolonized island and underwent a massive degree of speciation to adapt to the environment of the island. This is precisely what one would expect if the species of islands had arisen by evolution.
Meet Jimmy Lin, "Medical and Scientific Doxologist"
In our current culture, we're defined by our jobs. It's having a vocation. I wanted to shift away from that. I didn't want to be a doctor first and foremost, or a scientist, but one who praises God.
Series: Genes, Cells, and the Changing Face of Technology (2 entries)
BioLogos interim web editor Emily Ruppel recently traveled to Boston for the American Association for the Advancement of Science (AAAS) conference, where she took an afternoon off from lecture-going to catch up with Doug Lauffenburger, head of the biological engineering department at MIT and a member of the American Scientific Affiliation.
A Scientific Commentary on Genesis 7:11
Although committed to the principle of sola Scriptura, Calvin recognized that the Bible would have been written in terms its original recipients would have understood. Calvin inherited the medieval cosmology of his time, a way of viewing the world heavily influenced by Greek thought and one which was about to receive shocks from astronomers such as Copernicus and Galileo. But not just yet.
Series: Made in the Image of God: The Theological Implications of Human Genomics (4 entries)
This series by Denis Alexander reflects on advancements in genomics as well as their theological implications. He focuses on the relatedness of hominin genomes, arguing that this does not interfere with the image of God in humans. The image of God depends more on the capacity for relationship and covenant, not on a list of particular physical qualities. He then discusses why the recent studies of genomics provide "no grounds for genetic determinism."
Series: Behe, Lenski and the "Edge" of Evolution (5 entries)
In this series, we reexamine the claim made by Intelligent Design proponent Michael Behe to have found a limit to "Darwinian" evolution in light of recent results from the laboratory of Richard Lenski.
Series: Decoding ENCODE (8 entries)
The BioLogos Foundation explains to the findings of the Encyclopedia of DNA Elements (ENCODE) project and responds to the claims that its discoveries challenge the theory of evolution, especially regarding so-called "junk DNA".
Series: Biblical and Scientific Shortcomings of Flood Geology (6 entries)
Gregg Davidson and Ken Wolgemuth seek to remove the stumbling block of the Genesis flood in this four part series. Though many believe in an ancient world-wide flood, the evidence given does not hold up to geological scrutiny, but points rather to something regional instead. It is their hope that Christians will not walk away from faith in Christ simply because a global flood is not supported by science. Looking at natural phenomena like the Grand Canyon, salt beds, and fossil deposits, they reveal reasons for these deposits and structures while showing that their origin did not stem from a violent flood that covered the planet.


text:
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Cache, Studies.
October 27, 1910.
District Forester,
Ogden, Utah.
Dear Cir:
I am sending you a report on ray ecological studies
on the Cache National Forest, also*-grazing reconnaissance report which is accompanied by map of the area covered.
I am also sending 65 specimens of plants, in three
registered packages, through the District Office to be forwarded to Vashington for identification.
Very truly yours,
3 Enclosures.
Q //CC^Cv--^^


text:
Surgery: What to Expect
Topic Overview
Surgery is done for many reasons. Often it is done to repair an injury, such as a broken bone, or to relieve symptoms, such as numbness caused by a herniated disc. Sometimes it is done to diagnose a condition (biopsy) or to cure a condition, such as appendicitis.
Many minor surgeries can be done in your doctor's office or at a same-day surgery center. Preparing for minor surgery may take only a few hours. Major surgery is usually done in a hospital operating room. Except in an emergency, major surgery may require days or even weeks of testing and preparation.
Before surgery, your surgeon may ask you to see your regular doctor for an exam and possibly tests. A surgeon may ask this to make sure that surgery is not likely to be too hard on you.
You will also have an appointment with your surgeon before your surgery. For this appointment, take along a surgery question form(What is a PDF document?) to help you understand your treatment. Your surgeon will explain why your surgery is needed, what it will involve, what its risks and expected outcome are, and how long it will take you to recover. Talk to your surgeon about any concerns you have about the surgery. You may also want to ask about treatments you might try other than surgery.
Your surgeon or a nurse will give you a list of instructions to help you prepare for your surgery. Most surgery centers and hospitals have a before-surgery (preoperative) form and a surgery consent form for you to fill out. You may also need to sign a form that identifies the correct body area for surgery. This information helps the surgical team prepare for your surgery.
After surgery, you will be taken to a recovery (postoperative) area where nurses will care for and observe you for 1 to 4 hours. Then you will either be moved to a hospital room or go home. If you go home, the recovery nurse usually gives you written instructions to follow. Your surgeon may also give you special instructions.
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This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


text:
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text:
Level 7
Hints for the challenges will be asked and given in here.
Moderators: UncleTimmy, mjpieters
Enjoying the challenge? Need a hint?
Make a donation and help keep the site running! -thesamet
Make a donation and help keep the site running! -thesamet
I've tried downloading the library at effbot, but I can't get it to work. The Windows binary can't find the registry entry, so I ran the register tool provided, but that couldn't find the python package it needed to manipulate the registry. I tried compiling from source, but it crashed, illegal operation-style. I'm running Python 2.4 under Cygwin under Windows 98.
On the right track?
I'm pretty sure that this is not a spoiler because it didn't help me. Does 'smart guy, you mad' mean anything to you? Is it important? Am I on the right track, or have I been misled?
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text:
Some information is missing or invalid below.
Learn more.
For the ultimate fan. Gear up for game time wearing this men's Texas Longhorns stainless steel digital schedule watch.
- Digital display with EL backlight and team logo makes reading easy.
- Mineral-crystal face cover prevents scratching.
- Scroll feature shows upcoming games, locations and times.
- Specially designed USB connector allows you to update your team's schedule.
- School fight song plays at the start of each game to ensure you don't miss start time.
- Day display, alarm and hourly chime keep you on track.
- Stainless steel case promises lasting shine.
- Adjustable black strap offers a custom fit.
- Details:
- Online exclusive
- Stainless steel back
- Battery operated
- Manufacturer's 1-year limited warranty
- Model no. COL-SW-TEX
- Promotional offers available online at Kohls.com may vary from those offered in Kohl's stores.
Sponsored Links
The links below are ads provided by the Google AdWords™ program. Outside companies pay to advertise via these links when specific phrases and words are searched. These ads are provided by Google and are labeled as sponsored links. Clicking on these links will open a new tab displaying that respective company's own website. The website you link to is not affiliated with or sponsored by Kohls.com


text:
Clarithromycin; Erythromycin; Telithromycin/Slt QT Agents
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your antibiotic can affect your heart's rhythm. Other drugs can have the same effect.
What might happen:
Taking your antibiotic with other agents that can affect your heart rhythm may increase your risk of irregular heartbeat, which may be life-threatening.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to perform an electrocardiogram (ECG) on you to check your heart's rhythm. Let your doctor know right away if you notice an irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
2.Uroxatral (alfuzosin hydrochloride) US prescribing information. Sanofi-Synthelabo, Inc. May, 2013.
3.Apokyn (apomorphine hydrochloride) US prescribing information. Tercica, Inc. July, 2010.
4.Foradil Aerolizer (formoterol fumarate) US prescribing information. Schering Corporation September, 2012.
5.Tequin (gatifloxacin) US prescribing information. Bristol-Myers Squibb Company January, 2006.
6.Factive (gemifloxacin mesylate) US prescribing information. Oscient Pharmaceuticals August, 2013.
7.NegGram (nalidixic acid) US prescribing information. Sanofi-Synthelabo, Inc. November, 2012.
8.Noroxin (norfloxacin) US prescribing information. Merck & Co., Inc. August, 2013.
9.Votrient (pazopanib) US prescribing information. GlaxoSmithKline November, 2013.
10.Noxafil (posaconazole) UK summary of product characteristics. Schering-Plough Ltd. February 2, 2006.
11.Edurant (rilpivirine) US prescribing information. Tibotec Pharmaceuticals June, 2013.
12.Gilenya (fingolimod) US prescribing information. Novartis Pharmaceuticals Corporation May, 2012.
13.MHRA United Kingdom. Fingolimod (Gilenya): transient bradycardias and heart block after first dose - strengthened cardiovascular monitoring. Drug Safety Update Feb 2012;5(7):A1.
14.Cipro (ciprofloxacin hydrochloride) US prescribing information. Bayer Corporation August, 2013.
15.Ciproxin (ciprofloxacin hydrochloride) UK summary of product characteristics. Bayer plc April 13, 2010.
16.Primovist (gadoxetate disodium) Australian prescribing information. Schering-Plough Corporation November 1, 2005.
17.Primovist (gadoxetic acid) UK summary of product characteristics. Bayer plc May 1, 2008.
18.Istodax (romidepsin) US prescribing information. Celgene Corporation June, 2013.
19.The University of Arizona Center for Education and Research of Therapeutics. Drugs with Risk of Torsades de Pointes and Drugs with Possible Risk of Torsades de Pointes. Available at:http://www.crediblemeds.org/. Updated March 14, 2013.
20.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.


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Choose from a huge selection of T-shirts from Sportsman's Guide. These Men's Shirts come in a variety of styles and fabrics to ensure you get exactly what you are looking for. Choose from styles like Pocket T-shirts, Work T-shirts, Crew Neck T-shirts, Camo T-shirts, Hunting Shirts, and more!
A T-shirt is really great for any occasion, can you ever really have too many? Check out some of our popular brands like Carhartt, Jerzees, Guide Gear, and Jack Daniels to mention a few.


text:
Melissa's Q & A
Who's your favorite sports team, and why?
Minnesota Wild, Gotta show love and support to Minnesota :)
What's your favorite video game, and could you kick our butts at it?
I am still stuck on Super Nintendo! Gotta love Mario Allstars. I could definitely kick some ass at that game. I also like racing games like ATV Offroad.
Piercings/Tattoos (How many? Where?)
1 tattoo on my lower back, ear piercings and belly button piercings
What's the most memorable pick-up line you've ever heard?
Guy: What's your jacket made out of? Me: I dont know? Cotton? Guy: It looks like girlfriend material to me.
It's 4AM after a crazy night out – what are we eating?
Chips and top the tator!
What's the strangest thing in your fridge right now?
My fridge usually has a lot of very strange foods in it. I have weird tastes buds as some would say. I like eating exotic foods, the more exotic and strange, the more I will like it!
What do you feel sexiest wearing?
My go-to outfit when I want to feel sexy is a little black dress. Every woman should have one ;) When I am relaxing around the house, I feel sexiest and the most comfortable wearing yoga pants and a tank top.


text:
September 21, 2014
Back to Your Favorite TV Shows Celebrate Halloween
TV Squad Hot Topics
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From Our Partners
- Meet The Master of 'The Strain': Robin Atkin Downes on How He Came Up with the Distinct Voice
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- Outlander Post Mortem: Sam Heughan Bares All About the Wedding Night
- Outlander Recap: Virgin Territory
- More From TVLine


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The tornado that struck Oklahoma last Monday took a devastating toll in the number of lives lost and property destroyed. But amidst the anguish and destruction there is another "heart-wrenching" tragedy - displaced pets.
About 75 dogs from Oklahoma City went up for adoption on Monday, at PAWS Chicago. The homeless dogs were rescued from shelters this weekend, as tornado victims' pets flooded the limited space.
"We saw her online and we saw her get out of the van this morning, and I thought, 'Oh, I wonder if she's the one,'" said Lori Gentile, who adopted a dog, Lettie, on Monday. "She's perfect."
PAWS medical and intake teams left for Oklahoma City on Thursday afternoon, while volunteers in several vans left Friday afternoon. The vans returned late Saturday night to the Rescue & Recovery Center at 3516 W. 26th St. in Lawndale with the homeless dogs.
The dogs were bathed and fed, then get vaccinations, microchips and spay/neuter surgeries on Sunday. Sick or injured animals received medical treatment and will be placed in foster homes until they recover.
The healthiest of the pets were put up for placement at PAWS' Adoption Center at 1997 N. Clybourn in Lincoln Park on Memorial Day.
Oklahoma City Animal Care & Control took in 150 displaced pets right after the storm and will hold those animals for at least 30 days, to give owners time to find them.
"These are dogs that we know have an owner, but we can't find them right away," PAWS Chicago Executive Director Rochelle Michalek said. "In sheltering there is not infinite space, so that means other dogs must be euthanized to make room for the disaster dogs."
Michalek said that is not a pleasant thought, but the tornado dogs come first.
"We were all touched in some way by what happened down there. Imagine leaving for work in the morning and coming home at night to find your life destroyed," she said. "Pets are a big part of our lives, and to lose your pet along with everything else is just heart-wrenching.
"But it's also sad that the influx of displaced dogs will mean others lose their lives," Michalek said. "So that is why we are going."
"We don't want them to have to euthanize to make room for the storm dogs," PAWS spokeswoman Sarah Ahlberg said. "The goal is to free space in Oklahoma shelters, enabling them to assist animals displaced by the tornado."
PAWS, as it has in other disasters, made an emergency response mission to Oklahoma, sending medical teams and volunteers to bring pets back to Chicago.
"We brought back about 240 Katrina dogs," Michalek said, "as well as dogs from the Iowa floods. During the flooding in Marseilles, we set up an emergency food bank for families with pets and little else."
About 75 dogs, some in need of medical care, were brought back from Oklahoma and placed into PAWS' adoption program.
The mission required a mammoth volunteer effort. Michalek said the community response has been "wonderful" so far, with more than 225 volunteers already scheduled and more welcome.
Due to the size and short timeframe, PAWS accepted untrained volunteers to do some of the work that does not involve handling animals.
"We will do some quicky training sessions for people as needed, and the people who have not been trained can do other things such as cleaning and preparing shelter space, and feeding."
Michalek said this is just the first trip to Oklahoma.
In about 30 days, when families have had time to find lost pets, "we will go back down to get more," she said -- this time, storm orphans who were not reunited with families.
Anyone wishing to volunteer can email email@example.com. To provide a foster home, email firstname.lastname@example.com or call (773) 475-9464. Or to donate to the effort, visit the PAWS website or visit its Facebook page.
Follow @fox32news
205 N. Michigan AvenueGround FloorChicago, IL 60601Station Operator: (312) 565-5532Newsroom: (312)565-5533


text:
Pretty awesome events transpired during the Men's Sprint Free Final.
Unfortunately Russian cross-country skier Anton Gafarov wiped out mid-race.
Even though he knew he was out of medal contention, he decided to try to reach the finish line anyway.
After falling multiple times while attempting to basically ski one-legged, Canadian ski coach Justin Wadsworth literally sprinted onto the course with a replacement.
Anton was able to eventually finish the race, and even though he was a few minutes off of the leader, the crowd erupted, cheering him on for never giving up.
He returned the admiration by applauding the audience as he crossed the finish line.
That's what the Olympics are all about, Charlie Brown.
I can't embed the video on this page, but you can watch it HERE!


text:
When to Stop, When to Go, When to Slow Down
The college I attended was situated in a small western Pennsylvania town in an area heavily populated by one of the largest gatherings of Amish people found in the United States. The Amish are a delightful group totally committed to …Read More
When Towers Fall
When a catastrophe happens in our world, it is virtually certain that a question will come up: "Where was God?" People always seem to question how a good God could allow a terrible thing to happen.
The same question …Read More
When Wright Is Wrong
If you are a reader of contemporary theological works and you have not already encountered the name "N.T. Wright," you will. Wright is the Anglican Bishop of Durham, and he is one of the most prolific biblical scholars of our …Read More
Where and How Do We Draw the Line?
"In essentials, unity. In non-essentials, liberty. In all things, charity." Sounds nice, but which are which? Everyone wants to be unified in what really matters, to agree to disagree on what isn't as important, and to exercise love in all …Read More
Where East Meets West
I cannot count the number of times I've heard, "I believe there's a little bad in all that's good and a little good in all that's bad." The problem is not the number of times I've heard this but that …Read More
Where Is the Glory Found?
As birthdays go, it's a big one. It is fitting and appropriate that we would mark the five-hundredth anniversary of the birth of John Calvin. Trouble is, that occasion is being marked in at least two different ways. First, those …Read More
Where is Your Faith?
Living by faith is a multi-faceted endeavor. Trusting in the all-sufficient redeeming work of Christ is where we begin a life of faith. From there, the brilliance of this glorious reality is reflected and displayed in every area of our …Read More
Where Is Your Hope?
The story is told that a financially comfortable North American went to visit a mission church that was located in the village dump in a city in Africa. Wondering, he shadowed the pastor for much of the day until he …Read More
Where Is Your Treasure?
As I was flipping through the television channels recently, I was overwhelmed to see how secularism is influencing our culture today, particularly through advertising. In the teaching series Christian Worldview, Dr. Sproul describes secularism as that which looks at reality …Read More
Whitewashed Tombs
On March 10, 2008, the New York Times revealed that New York Governor Elliot Spitzer had been caught patronizing a prostitution ring. Two days later, Governor Spitzer appeared chastened before the public as he resigned from office. The story was …Read More
ArticlesBrowse select Tabletalk articles and columns exploring themes and topics across a spectrum of relevant issues.
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