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Last Thursday I received some 233 requests to accept some program at 3:00 a.m. I deleted all, but since that time I cannot get online with Outlook 2003. I can neither send nor receive emails from outlook; however, all other programs can access the internet and I can send email from yahoo without problem. Anyone else with this issue or with a solution?
Solved! Go to Solution.
I just chatted with a tech support person and tehy had me change my "personal Firewall Profile" to "home network"
1. Right click on the Trend icon on the system tray
2. Choose Switch Firewall Profile
3. Select Home Network
Thanks for your information. I made the change, but it did not solve the problem.
How about totally "temporarily" disabling your firewall just to check and isolate that it is not a firewall problem? From there maybe the other folks here can give more suggestions on how to solve the problem.
Hi. Was browsing through the posts here. It could be that you are still using an older version of Trend Micro. If you can post the program version here I might be able to help you out.
Here's how to do it. Open the Main Console then hit Help & Support. Then click Product Information and note down the Program Version. Post it here and I'll see what I can do.
Most of cant/ send recieve email problems are caused by:
A TM pop-up at the lower right side of your screen saying suspicious activity.... Outlook.exe (Allow/ Block)
User does not read through the message and Blocks the program > resulting to a blocked Outlook
Easy Work-Around: Change to a new profile
A new profile would not have Outlook blocked on it yet
1. Right-click on the red T-Ball icon near the clock.
2. Change Firewall profile > preferably to Home Network
Easy Solution
Reset to Default Profile. This erases all customizations for all profiles. Make sure you take the time to read the warnings before allowing/ blocking.
1. Open the Trend Micro.
2. Go to Personal Firewall Controls > Personal Firewall > Settings
3. Click on Reset to Default Settings (Depending on version, you might need to click on Change Profile first.)
4. Make sure you change to the appropriate Firewall Profile afterwards.
Best Solution
Go to Program Controls and allow Outlook.
1. Open the Trend Micro.
2. Go to Personal Firewall Controls > Personal Firewall > Settings > Advanced Settings > Program Controls
3. Double click on your email program
4. Set to simple and allow
I've tried all of the suggestions above and still can't send. Was on chat with a verizon rep for over an hour last night. When he finished I could send and receive for about a minute and then it froze up again. Now I can receive but have to send from the Verizon site. What is safe to disable in Trend Micro?
07-19-2010 08:27 AM - last edited on 07-20-2010 09:14 AM by JSMO
How do you know its related to a trend product? Maybe the program that was attacking did somethign to the outlook registry items?
and what di the verizon guy have you change?
After talking with tech support at work, I de-installed Trend Micro and tested sending/receiving email. I WAS able to do so which let me know it was Trend (V 12) so I upgraded to 16 and installed it. Can now send and receive. Thanks


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Two vibrant round Kentucky blue sapphires, at approximately .15 carat TW, and one round ice blue sapphire, at approximately .07 carat, add color and pizzazz to this pendant. Crafted in quality sterling silver with unique milgrain detailing, the total gem weight is approximately .22 carat. The colorful pendant hangs from a matching 18-inch box chain with a two inch chain extender.
Order now for delivery on or before
Tuesday, September 30, 2014
using FedEx 2nd Day.

subset: commoncrawl


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Software Map
Tag cloud | Project Tree | Project List
Project tree
Now limiting view to projects in the following categories:
Development Status :: 5 - Production/Stable [Remove This Filter]
Intended Audience :: IT Staff [Remove This Filter]
Environment :: No Input/Output (Daemon) [Remove This Filter]
Development Status > 5 - Production/Stable
Browse By:
2 projects in result set.
|0. NSS and PAM Modules - PAM and NSS modules for linux and BSD
|Activity Percentile: 49.21
Activity Ranking: 65.00
Registered: 2004-09-14 06:12
|1. Clear xlog tail - A stand-alone executable filter to zero the unused portion (if any) at the tail of a WAL (xlog) file. Its primary usage is to allow better compression of WAL files before transfer and/or storage. Useful in an archive_command statement or script.
|Activity Percentile: 0.00
Activity Ranking: 0.00
Registered: 2007-10-30 18:17


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Tuesday, 16 Apr 2013 02:51 PM
By Newsmax Wires
© 2014 Newsmax. All rights reserved.
Monday, 29 Sep 2014 23:12 PM
The American Federation of Teachers is on track to spend $20 million on midterm elections this year – more than ever bef . . .
Monday, 29 Sep 2014 19:31 PM
Conservatives in Colorado are organizing an all-volunteer "Election Protection Squad" to videotape voters as they drop o . . .
Monday, 29 Sep 2014 19:13 PM
Sen. Ted Cruz may be getting ready to announce a presidential run at the end of the year, and is concentrating on foreig . . .
No liberal radio show has ever made it, because they are stupid. People love...
Long overdue, can't say I wish him well....
Just another example of the lawless obongo regime. Lois Lerner goes free.
Your perpetual state of socialist bliss is possible due to the
Ohhhhh but of course allow a man whose whole career has been hatred, race...
Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.


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Your style will bloom year-round with these classic sterling silver earrings. A sterling silver flower at the post extends down the earrings in a vine-like design. These earrings will brighten your day with their floral cheer and the left and right design will frame your face perfectly. Earrings measure 1-1/4" long x 1" wide with post and clutch closure. Made in America with gemstones from around the world.
Like all fine jewelry, Carolyn Pollack Sterling Silver Jewelry should be handled carefully. Store jewelry in a plastic bag, dry and wrapped in tissue paper, when not being worn or displayed. Clean sterling silver with a silver polishing cloth when necessary, but never subject to chlorine, silver dips, chemical solutions or ultrasonic cleaners, as these substances can cause the genuine gemstones to discolor. Never wear jewelry in a swimming pool.


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Work-Related Lung Disease Surveillance System (eWoRLD)
Occupational Respiratory Conditions Due to Toxic Agents: Morbidity (Archive)
Occupational respiratory conditions due to toxic agents: Estimated rate (based on cases reported by employers, per 10,000 full-time workers) by industry division, U.S. private sector, 1973-2000
- indicates no data reported or data that do not meet BLS publication guidelines.
Note: Respiratory conditions due to toxic agents include pneumonitis, pharyngitis, rhinitis or acute congestions due to chemicals, dusts, gases or fumes. The sum of industry divisions may not equal the total due to rounding. See appendices for source description.
Source: Bureau of Labor Statistics annual reports of occupational injuries and illnesses.
Reference Number: 2002T11-02
Date Posted: May 2003
Contact Us:
- Centers for Disease Control and Prevention
- National Institute for Occupational Safety and Health (NIOSH)
24 Hours/Every Day
- email@example.com


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Epidemiological Studies Underway
Performing epidemiological studies of cancer risk from diagnostic imaging requires researchers to follow hundreds of thousands of patients for decades. That is why, to date, estimates on cancer risk from diagnostic imaging have relied on modeling studies.
Researchers are now performing the first epidemiological studies of this kind. One study, being led by Dr. Elaine Ron of NCI's Radiation Epidemiology Branch (REB) in collaboration with Dr. Mark Pearce from Newcastle University in the United Kingdom, is following over 250,000 people who were less than 22 years old at the time of their first CT scan. The researchers are tracking cancer incidence and mortality in this population and expect to have preliminary data available in approximately 2 years.
A second REB study is following a similar population in Israel (50,000 people who were less than 18 years old at the time of their first CT scan), in collaboration with Dr. Gabriel Chodick of Maccabi Healthcare Services. There are plans to pool the data from these two studies with data from additional studies planned in Europe, Australia, and Canada "to provide a reasonable picture of the risk from childhood CT scans," said Dr. Berrington de González.


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UniBond Easy Smooth Sealant is the ultimate tool for easy-to-use sealing. The Easy Smooth blend is the perfect partner to this easy application system. The patented silicone is easy to clean, smooth and correct ensuring you get a perfect seal first time. Suitable for use in most situations around your home.
*Free delivery over £50 refers to home delivery orders placed on diy.com only. Charges refer to the value of goods being delivered and excludes delivery from stores or services. Excludes bulk delivery.
B&Q accepts the above cards and also offers a range of in-store financial services. Learn more
Buy online, return in store. Terms and conditions apply
Have a question or a problem, chat to our support team now.contact B&Q
© B&Q 2014 - Terms & Conditions


text:
Use the Entire Site search box on the top of the page to return results across all our sites.
Rolling Stone magazine, founded in San Francisco in 1967, is the most famous music periodical in the world. Initially reporting on the hippie counterculture, by the 1970s, Rolling Stone made its mark for political coverage as well with the likes of "gonzo" journalist Hunter S. Thompson's submissions and many other prominent writers.


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1 prepared round sponge cake
1 batch prepared icing
1 bag jelly beans
Black licorice
1 large packet desiccated coconut
4 drops green food coloring
- 1.Cut prepared round cake in half.
- 2.Place frosting on one half of the cake.
- 3.Put the two pieces together.
- 4.Stand flat edge of cake on cake plate, and cut a notch out. This will form the neck of the bunny.
- 5.Place the cake and frosting that you cut out onto the back of the cake. This forms the bunny tail.
- 6.Frost the entire cake.
- 7.Cover the cake with desiccated coconut.
- 8.Add jelly beans for eyes and nose.
- 9.Add licorice for whiskers
- 10.Cut ears out of pink heavy-weight paper and fold in the middle. Push into cake.
- 11.Take approximately 1 cupful of coconut, and add 4 drops of green food coloring.
- 12.Mix coconut and green food coloring until the coconut is well covered.
- 13.Place the green coconut on the plate around the bunny. Add jelly beans to the grass.
Enjoy your Easter Bunny Cake and Happy Easter!
Get your recipes from http://929wlmi.com/shows/show/smokin-joe/
By Danaimge (Own work) [CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0)], via Wikimedia Commons


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Dandelion Puff Pillow
Nothing captivates the imagination quite like the perfect circular shape and wonderful puffiness of a real dandelion, although our appliquéd pillows – with their buoyant, ruffled pom-poms – come close.
- 100% cotton with polyester fill
- Features a ruffled pom-pom designed to replicate the ethereal puffiness of a real dandelion
- Imported
- Spot clean
- In petal, grey, white, lilac or pool
- View bedding dimensions
Dandelion Puff Pillow
- 12" diam.
Dandelion Puff Pillow


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OK, here are my 2 pages, and they should be uploaded to 4shared. Let me know if problems. Thanks.
Last edited by kcsimpson99; 02-06-2009 at 03:34 PM.
Here is my page for the exchange.
Hey girls... I just checked all the beautiful quick pages you created and love them! All are great, I just fixed little details and now I'm uploading the zips to make it easier for you to download. Since it's done I'll PM you to download your whole albums and bonus. I had a great time and loved our exchange Hope to have another exchange soon!
Hey... take a look at the first post to see a preview of the album!
Thanks Dani, for hosting the QP exchange. I loved working with Guga's Brother kit, and the Add-on is so cute!! Thanks to you and the other ladies for the great pages!!


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Ph.D. in EE and Systems Sciences, Columbia University; M.A. in EE and Computer Science, Columbia University; Diplôme d'Ingénieur de l'Ecole Supérieure d'Electricité de Paris
Dr. Courtin has extensive experience as the CEO for a series of successful high-tech, Boston-based companies. As CEO, he negotiated alliances, joint ventures, and partnership agreements in more than 30 countries. Dr. Courtin currently serves on the boards of directors of Kashya Inc. and OpenNetwork.
(Part Time)


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Sol e Luna
Sol e Luna Hotel is situated 10 minutes from Essaouira's Medina, the old city. It is a part of a real Moroccan village with small local shops, petits taxis, donkieys, sheep and local buses offering fast and exotic rides to the city of Essaouira.
Sol e Luna offers six welcoming rooms, each guest will find her favorite color as well as a spacious bathroom and toilette - which is not the case in many local hotels!
Sol e Luna has also a secret weapon, Halima, a local farmer's wife, who cooks wonderful meals from spicy to sweet. Families with kids can also easily put together their own pizza or order a tasty French meal.
The owners of Sol e Luna, Emilie and Christophe, make you feel at home as soon as you open the door. The cat comes to say hello too, as well as some turtles and budgericar - Sol e Luna also welcomes and takes care of children of all age; Babysitting service available.
Terrace and garden open for everybody, safe and free parking for cars.
Sol e Luna also organises all the trips you want from kite surfing and riding to guided tours in Essaouira. To relax you Sol e Luna works together with the best hammam of the town.
Availability & RatesTo view availability and prices please select dates and click 'Update Dates'
Hotel Facilities & Policies
- Airport transfers
- Bar
- Breakfast Included
- Breakfast not included
- Direct dial telephone
- Fax Service
- Free Parking
- Internet Access
- Laundry Facilities
- Restaurant
- Tours/Travel Desk
Cancellation PolicyThis property has a 3 day cancellation policy. Failure to cancel within this time will result in a cancellation charge equal to the first night of your stay.
Must-Read Hotel InfoThis property has specific Terms & Conditions.
Please note:
Check in: to check with the property
Check out: after 16.00 pm
Cancellation Policy: 3 days
Credit cards not accepted
Breakfast is not included
Groups accepted
DirectionsShow MapHide Map
From Essaouira
Take the direction of Agadir, to 7 km, the hotel is on your right before the crossroads
Km 8 before and called the new city of Ghazoua. By bus: take line 4 of the Lima Bus Company. Off at Sol e Luna (Ex Belle de Mai).
From Marrakech
After the village Ounagha to 5 kms then at the roundabout turn left towards Agadir,
to 25 kms. Cross the new city of Ghazoua towards Essaouira, the hotel is
on your left.
From Agadir
Head toward Casablanca. 3 km after the turnoff to the airport of Essaouira
you will find a crossroads (Directions Essaouira, Casablanca / Marrakech). Cross
the new city of Ghazoua towards Essaouira, the hotel is on your left.
Located Near
Located at the gates of Essaouira, 'Sol E Luna' has the temperate climate of the land. The Riad is located 5 minutes from beaches and 10 minutes from the Medina. The sun is present all throughout the year and pleasant temperatures all year round.
Only 8 minutes from Essaouira.
golf, beach (surf, kite surf) Essaouira Medina


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The Glenbrook Apaches will advance to their third straight appearance in the MAIS AA State Championship Series after beating River Oaks in the North State Finals, 7-0, on Friday.
The Apaches were the State Champs two years ago and runners-up last year.
"I was real proud of the way we played," Glenbrook coach Jonathan Hardy said. "We had a really good performance defensively and on the mound. We had no errors and no walks."
Glenbrook scored all seven runs in the first two innings and held River Oaks scoreless behind the outstanding pitching of Logan Clark.


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Request a quote now online with Connell Nissan.
Submit our trade-in form and we'll get back to you quickly with an appraised value.
Schedule a service appointment for vehicle maintenance, repair or inspection.
Looking for a specific part or accessory? Submit your inquiry and we'll track it down.
See the latest finance specials and incentives, designed to maximize your savings!
There's a reason why Connell Nissan is a premier new Nissan and certified used Nissan dealer for Costa Mesa. It's because we provide quality automobiles at prices our customers can afford. Our knowledgeable staff will answer your questions, help you find the right new car, and can assist with financing. So if you're looking for a new or used Nissan in Irvine, Huntington Beach or Tustin, stop in to Connell Nissan and we'll get you into the car of your dreams! Have questions to ask first? Give us a call.
At Connell Nissan we strive to maintain a complete inventory of new Nissan vehicles. Select from all of the latest Nissan models including the new 2013 and 2014 Nissan Pathfinder, Altima, LEAF, Versa, Sentra, 370Z, Cube, Murano in Costa Mesa and more. We are the Costa Mesa area Nissan car dealership that will make the car buying experience as simple as possible. Take a test drive with one of our Nissan experts and see what makes these some of the best selling vehicles in America.
Connell Nissan's used vehicles are carefully inspected by our technicians to guarantee quality for our Costa Mesa customers. We are continually receiving vehicles for our used car inventory, so check back often. Visit our inventory page to browse through the Costa Mesa used cars we currently have in stock. If you see something you like, give us a call or stop in and see us at 2850 Harbor Blvd..
For a low interest rate car loan in Costa Mesa, visit the experts at Connell Nissan. We've helped people get the car loans that fit their budget so that they could drive away with a new or used car quickly. Regardless of your credit status we can help. No credit or bad credit? No problem. Come down to 2850 Harbor Blvd. and speak to a financial professional. An affordable car loan or lease is within reach at Connell Nissan.
At Connell Nissan we want you to get the most miles out of your new or used car which is why we offer services to keep your vehicle in top condition. Our greater Costa Mesa Nissan car repair center features some of the area's most skilled mechanics. Sign up for a service appointment online and our auto technicians will get your Nissan repaired as quickly as possible. Connell Nissan also stocks a comprehensive inventory of Nissan car parts in Costa Mesa so that you can repair or customize your automobile. Our parts specialist are standing by to help locate the component you need to get your vehicle back on the road.
As you can see from the above, Connell Nissan is a full-service Costa Mesa new and used car dealership. We're dedicated to providing the best service possible, and will assist you through the purchasing process any way we can. Visit us at 2850 Harbor Blvd., and read more about us.
Best Nissan Dealer Servicing All Of Orange County, California


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We have record or near record low levels of vaccine preventable childhood diseases in the United States, but that does not mean these have disappeared. Many of the viruses and bacteria are still circulating in this country or are only a plane ride away. That's why it's important that children, especially infants and young children, receive recommended immunizations on time. In our mobile society, over a million people each day people travel to and from other countries, including countries where many vaccine preventable diseases remain relatively common. Without vaccines, epidemics of many preventable diseases could return, resulting in increased– and unnecessary– illness, disability, and death among children.
[Vaccination schedule for children]
The following vaccine-preventable diseases, not long ago, disabled and killed millions of American children. Thanks to our country's high childhood immunization coverage levels, these diseases are now very uncommon.
A respiratory disease caused by bacteria
Gradual onset of a sore throat and low-grade fever
Airway obstruction, coma, and death if not treated
Spread by coughing and sneezing
Diphtheria toxoid (contained in DTP, DTaP, DT or Td vaccines) can prevent this disease.
A severe bacterial infection, occurring primarily in infants
Skin and throat infections, meningitis, pneumonia, sepsis, and arthritis
(Can be serious in children under age 1, but there is little risk of getting the disease after age 5)
Hib meningitis (death in one out of 20 children, and permanent brain damage in 10% - 30% of the survivors)
Hib vaccine can prevent this disease.
Hepatitis A
A disease of the liver caused by hepatitis A virus
Potentially none (likelihood of symptoms increases with the person's age)
If present: yellow skin or eyes, tiredness, stomach ache, loss of appetite, or nausea
Because young children might not have symptoms, the disease is often not recognized until the child's caregiver becomes ill with hepatitis A.
Most often: spread by the fecal-oral route (An object contaminated with the stool of a person with hepatitis A is put into another person's mouth.)
Less often: spread by swallowing food or water that contains the virus
Hepatitis A vaccine will prevent this disease.
Hepatitis B
A disease of the liver caused by hepatitis B virus
Potentially none when first infected (likelihood of early symptoms increases with the person's age)
If present: yellow skin or eyes, tiredness, stomach ache, loss of appetite, nausea, or joint pain
The younger the person, the greater the likelihood of staying infected and having life-long liver problems, such as scarring of the liver and liver cancer
Spread through contact with the blood of an infected person or by having sex with an infected person
Hepatitis B vaccine is will prevent this disease.
A respiratory disease caused by a virus
Measles virus causes rash, high fever, cough, runny nose, and red, watery eyes, lasting about a week.
Diarrhea, ear infections, pneumonia, encephalitis, seizures, and death
Spread by coughing and sneezing (highly contagious)
Measles vaccine (contained in MMR, MR and measles vaccines) can prevent this disease.
A disease of the lymph nodes caused by a virus
Fever, headache, muscle ache, and swelling of the lymph nodes close to the jaw
Meningitis, inflammation of the testicles or ovaries, inflammation of the pancreas and deafness (usually permanent)
Mumps vaccine (contained in MMR) can prevent this disease.
Pertussis (whooping cough)
Severe spasms of coughing that can interfere with eating, drinking, and breathing
Pneumonia, encephalitis (due to lack of oxygen), and death, especially in infants.
Pertussis vaccine (contained in DTP and DTaP) can prevent this disease.
A disease of the lymphatic and nervous systems
Fever, sore throat, nausea, headaches, stomach aches, and stiffness in the neck, back, and legs
Paralysis that can lead to permanent disability and death
Contact with an infected person
Polio vaccine (IPV) can prevent this disease.
Rubella (German measles)
Rash and fever for two to three days ( mild disease in children and young adults)
Birth defects if acquired by a pregnant woman: deafness, cataracts, heart defects, mental retardation, and liver and spleen damage (at least a 20% chance of damage to the fetus if a woman is infected early in pregnancy)
Rubella vaccine (contained in MMR vaccine) can prevent this disease.
Tetanus (lockjaw)
Varicella (chickenpox)
(Information provided by the Centers for Disease Control and Prevention.)


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Encore Airings: Thursdays at 11 PM ET/PT
SACRED COWS GET SLAUGHTERED HERE No one is safe with Penn & Teller on the beat. With their trademark wit and wiles, this irreverent duo takes on the people who take America for a ride.
WATCH ALL EPISODES ON SHOWTIME ANYTIME Watch Penn & Teller anytime, anywhere on your computer, tablet, phone or TV streaming device -- FREE with your SHOWTIME subscription.
WATCH ON DEMAND Catch up on Penn & Teller on Showtime On Demand.
Order Showtime, Get $50 Get unlimited access to hit series, movies, sports & more. Plus, watch wherever and whenever on Showtime Anytime, free with your Showtime subscription.
Inside Comedy
Watch this comedy documentary series from veteran funny-man David Steinberg and Steve Carell as they reveal the inspirations, influences and idols of some of the greatest comics of our time.
Season 8 on DVD
Bring home Season 8 of Penn & Teller today.
Reality on Showtime
Check out other great reality series and documentaries on Showtime.
About the Series
This daring original series stars postmodern bad boys of magic Penn & Teller as they question many of our culture's most cherished and widely held beliefs. From the truth about palm readings and TV psychics to the reality behind Feng Shui and Ouija boards, the archly comic masters of misdirection host this eye-opening analysis of the middle-ground between perception and reality.


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Prairie Spirit Trail State Park
419 S. Oak
Garnett, KS 66032
Garnett Area Chamber Of Commerce - (785) 448-6767
The trail is built upon a railroad Right-of Way which was the first north -south rail line in Kansas. The rail line was constructed in the1860's.
The only rail-trail in the Kansas State Park system, Prairie Spirit Trail is a unique linear park through three counties in eastern Kansas with eight pocket parks along the way. It is a greenway and travel corridor open to pedestrians and bicyclists traversing diverse ecosystems including tallgrass prairie, riparian areas, agricultural lands, and communities.
The trail is a hard packed limestone screening surface in rural areas. Portions of the trail are asphalted through Garnett and Ottawa. The trail averages a minimum of 8 feet wide. The grades are moderate and follow original railroad grades.
Camping is not allowed along the trail, but is available nearby in the City of Garnett.


text:
Base Layer Tops
Mountain Hardwear
Priceless than $25
$25 - $49.99
$50 - $99.99
$100 - $199.99
$200 - $299.99
$300 and above
Recent Base Layer Top Reviews
First Lite Chama Hoody
My First Lite merino clothing keeps me comfortable in the cold mountain mornings and when I am hiking during the warmer parts of the day. Great for layering or for sleeping in on those cold nights. Pull the hood up, cinch it down for added warmth. The Chama Hoody is a versatile top. It can be used as a base layer on those cold hikes through the woods, or as a stand-alone sweater on those days where a jacket is too much. The hood, with its cinch string, is useful in a cool environment, but you will… Full review
SmartWool Men's Microweight Crew
A well-made, Merino wool baselayer that has gotten me through the insane cold of January 2014. It's a bit short in the torso for this 6'2" guy. The regular price is a bit higher than I think the product is worth. While I agree SmartWool makes good products, I also believe the price is driven by the name. For that reason, I seldom buy SW products unless I find them deeply discounted. Such was the case with the SmartWool Microweight Crew shirt, which I picked up for $36. While I am satisfied with… Full review
SmartWool Women's Midweight Crew
Great wicking wool top! I've used this as a base layer this winter for daily walks in the ever changing New England weather, on runs and while cross country skiing. Would recommend this top for anyone looking to stay warm and dry while being active. I love this top! The sleeves are long enough to pull down over my fingers when cold and loose enough to fold back when I've warmed up. The length is perfect, long enough to tuck in or leave out with no gap at the waist. I've used this as a base layer… Full review
Wild Country Lightweight Base Layer Top
A mediocre base layer that probably won't last long in the market, as it doesn't fit well. I picked up this item on sale for $6 at Sierra Trading Post. I have not seen it sold elsewhere. I wore it nearly every day during the month of December, both indoors and outdoors. Had I paid the suggested retail price of $20, I would have felt this was a waste of money. The shirt arrived in its own stuff sack. This struck me as a bit odd and unnecessary. I appreciated the shirt's tagless design. Care for the… Full review
Stoic Men's Alpine Merino 150 Crew - Long-Sleeve
Great baselayer! Bought a couple of these on steepandcheap.com for about $30! What a great price for a merino wool baselayer. I've been out with them twice now in the Colorado winter and was impressed on how they regulated body temperature. The sleeves have thumb holes which come in handy to keep your hands warm. They are barely noticeable when not in use. I'm happy with this shirt so far and can't wait to wear them in the backcountry for a couple of days! Full review
Icebreaker Men's Bodyfit 150 Long Sleeve Crewe
Well worth the money. I always hang dry mine. It will keep you reasonably warm when it's wet or dry and I love to switch into it when I soaked a different undershirt on the hike up. Fits really nice, breathable, and very good construction. Full review
Icebreaker Women's Bodyfit 150 Long Sleeve Crewe
Women's version, really lives up to the hype. Definitely worth the money. Merino wool keeps sheep warm in winter and cool in summer. Period. It will do the same for you. Once you go wool you're never going back to synthetic for base layer comfort. I always smelled like a barn animal after hiking and camping in a synthetic base layer. No problem anymore. Not only does the merino shirt do better it actually inhibits bacterial growth, the difference is overwhelming. This material is not the scratchy… Full review
Patagonia Men's Merino 2 Lightweight T-Shirt
Nice fit, no itch, use as base in cooler temps or alone in warm temps. I put off buying due to cost, but wish I saved up and got one sooner. I use this as a base in cooler temps and alone when it's warmer. It's nice because it dries quick so when you slow down on a hike or cool breeze comes up I remain comfortable. No seam on your shoulder, requires more care when washing. Full review
Icebreaker Men's Oasis Long Sleeve Crewe
Wonderfully smooth to the touch, no itch, and good looking base layer shirt. Ideal for everyday wear, hiking, outdoor sports, hunting/shooting, etc as it has great freedom of movement across the shoulders and no binding. I have 1 of these in blue with contrasting white stitching and its a very nice base layer shirt that comes at an outrageous price. Despite being sold by a discount outlet, and further reduced on their close-out page, this is a glorified undershirt that costs $50. Not sure what the… Full review
Top-Rated Base Layer Tops
Sort by: name | rating | price | availability | recently reviewed
Capilene 2 Lightweight Zip-Neck
Rho LT Zip
Lightweight Crew LS
Merino 2 Lightweight Crew
Capilene 4 Expedition Weight Zip-Neck
Midweight Zip T
Alpine Merino 150 Crew - Long-Sleeve
260 Midweight LS Crewe
Microweight Crew
Microweight Tee
260 Midweight Tech Top
Oasis Long Sleeve Crewe
Capilene 2 Lightweight Crew
Power Stretch Zip T
Tech Silk Crew
Midweight Crew
Capilene 1 Silkweight Scoop
Midweight Hoody
Midweight Crew LS
Lightweight Zip T
150 Ultralite LS Atlas
Capilene 2 Lightweight T-Shirt
Midweight Funnel Zip
Merino 3 Midweight Crew
GT 200 L/S Chase Zip
Midweight Zip LS
Zepher Zip T-Neck
Merino 2 Lightweight T-Shirt
Thermawool Merino Crew Top
Tech Long Sleeve Crewe
BodyFit 200 Oasis Printed
Oasis Long Sleeve Crewe Slopes
Anatomica Crewe
Quick Draw Crew Top
Silk Underwear, Crewneck
Integral Zip Tee
Micro Power Stretch Zip T
Base 3.0 1/4 Zip
Lightweight Long-Sleeve Crew Top
Phase SV Crew LS
Capilene 3 Midweight Crew
Warm Long-Sleeve Zip Neck
Polarskins Long Underwear Shirt - Lightweight
Lightweight Polartec Power Dry MTS Long-Sleeve Crew
Go Warm Longsleeve
Merino 3 Midweight V-Neck
Lightweight Asymmetrical Zip
Merino 1 Silkweight Tank
Capilene 3 Midweight Zip Neck
Tech T Lite Long Sleeve Roots


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Perfect Travel Jacket 2 2
Lovely Jacket This jacket is a lovely crepe material in a navy blue. Although it is styled as a safari jacket, it is not a safari jacket. It is more elegant and thinner fabric due to the crepe material. It just did not look good on me. I don't know if it's the boxy cut. I wish it came in a slightly smaller size (I ordered the size 6) It seemed to just hang on me. It has great potential, but I will not be keeping it. I do like crepe since it is a fabric that sheds wrinkles and looks elegant, but it does not seem to work too well with this style of jacket. March 22, 2014
Disappointed I was not happy with the fabric. It was shiny and cheap looking, and the jacket was cut small. In the past I ordered the khaki safari type jacket made beautifully, same style but cotton khaki material that has withstood the travel test many times over. I love that jacket! I was expecting the same quality in this jacket but it isn't even close. I am keeping the jacket just because I needed it to travel, and had no time to reorder before my trip so I have worn it. Doubt I will wear it again, however. May 17, 2013
1-2 of 2
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Morning DiscussionToday sees the North American release of Mass Effect 2 and, more importantly, the revival of an old favourite Shacknews tradition--the launch day discussion post. So please, keep your Mass Effect 2 out of Morning Discussion because people are avoiding spoilers, or perhaps live in Europe and the thought of anyone playing ME2 before Friday fills them with a furious rage.
So. Something else, then. Read any good books lately? It's not quite a book but I've been enjoying Judge Anderson: The Psi Files Volume 1, a phonebook sized collection of stories from celebrated British sci-fi comic 2000AD starring Judge Dredd's splendid psychic chum Judge Cassandra Anderson. There's a small exhibition of frequent Anderson artist Arthur Ranson's comic art at Orbital Comics near Leicester Square in London, if you're in the area and fancy seeing some rockin' pictures.
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finn cashmere pullover
by DEMYLEE
After graduating from Parsons School of Design, New York-based designer Demy Lee wanted to design what she appreciated most in her own closet, something she reached for just about every day...sweaters. Her line Demylee is a collection of understated basics and cashmere sweaters designed to be both current and classic. Cashmere is the foundation of her collection, to which she uses luxurious ultra fine yarns sourced from goats in Inner Mongolia. Back To Product View All From This Designer
Men's Size Chart
Product Details
Two tone, super soft cashmere sweater in a relaxed fit, with contrasting cuffs, collar and back body. Length hits just below hip.
• long raglan sleeves
• 100% cashmere
• dry clean only
• imported


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Getting dinner on the table just got a whole lot easier.
Get ready to throw the ultimate parking lot party.
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on June 23, 2009
I halved the recipe since I was only making it for a family of 4. I found the dough easier to work with by making smaller discs to cook. I did think the olive oil was a little much but that may be just my personal preference. Made for Photo Tagpeople found this review Helpful. You can only vote others' reviews helpful or not helpful... Was this review helpful to you? Yes | No We don't know who you are. Sign in or create an account
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yep.. it is all good.. easy fix..
I uploaded one tonight :)
love it... and I love your siggy even more
thank you to all who participated.. I think they all turned out fantastic.. I will go thru them all today and get them all zipped up and send you all a link and a coupon to get my set for free.. thank you all again so much!!
Thanks Heather - I loved this! And as a bonus we get some awesome quick pages, it doesn't get any sweeter than that!
My Blog: Randje's World
"You live and learn. At any rate, you live"
Douglas Adams
thanks for hosting the QP exchange
i have had so much fun with the kit
the pages are great!
I think i was confused thought this was a April Challenge so any way here is mine! in April!


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Local Weather Cameras
Habikino, Japan
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Stowe Mountain Ski Resort, Stowe, VT 05672
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Educational Resources
Many thanks to Bob Hatcher, Retired Coordinator (2001); Nongame and
Endangered Wildlife Tennessee Wildlife Resources Agency, for compiling
this comprehensive list of Eagle Resources for the American Eagle
Foundation. In addition, Bob answers all eagle-related questions which are generated by people visiting our website.
American Eagle Foundation, Tennessee
Decorah, Iowa - Spectacular Wild Bald Eagle Nest (posted April 3, 2011)
Alaska Webcams
National Conservation Training Center (USFW)
USFW Eagle Cam in Shepherdstown, WA
Northeast Utilities
Back to top
Golden Eagle Feather Use by Native Americans
U.S. Fish and Wildlife Service, National Eagle Repository
Possession of Migratory Bird Parts
Eagle Parts Repository Newspaper Article
American Bald Eagle Information
Bald Facts About Bald Eagles In Tennessee (pdf)
American Eagle Foundation
Eagle Scout Ceremony
Back to top
Endangered Species Unit on The Bald Eagle
Originally developed by Vanderbilt University's Learning Technology Center
Updated and Revised by Bob Hatcher, AEF
The Bald EagleAn elementary school unit developed by Sally Moorer
American Eagle Foundation
President Clinton Delisting Proposal, USFWS
Bald Eagle Delisting and Legalities
Back to top
Laws Related to Eagles
Laws that Protect Bald Eagles
Bald and Golden Eagle Protection Act
Endangered Species Act of 1973, USFWS
Lacey Act, USFWS
Migratory Bird Treat Act, USFWS
National Bald Eagle Management Guidelines
Bald and Golden Eagle Permits
Watching Eagles Grow
Bent's Bald Eagle Life History
General Life History, USFWS
Life Histories of Familiar North American Birds
Back to top
Life History of Golden Eagles
Life Histories of Familiar North American Birds
American Bald Eagle Information
Flag Display Code
Flag Display Protocol
Great Seal of the U.S.
Great Seal of the U.S. (Blazon)
Photos of Eagles
Webcrawler Images of Eagles
Google Images of Challenger, the Bald Eagle
Eagles in the Wild, Woodrow Dawson
Eagles and Birds of Prey, Ashley Hockenberry
Google Eagle Images
Eagle Photos on Flickr
Photos of Eagles Species of the World
Eagle Stock Images, John Herron
Eagle and Nature Photography, Rolf Hicker
U.S.Fish and Wildlife Service
Eagle Themed Merchandise, AEF
Bald Eagle Photo Gallery, AEF
Poems, Videos, & Songs About Eagles
Poems About Eagles
The Bald Eagles of Ancloteby Andrea Pico Estrada of Pinellas County, FL
When Challenger Flies
James Rogers
Save the Eagle Song, AEF
YouTube AEF Videos
National Geographic: Bald Eagles Come Back From the Brink
Bird Diseases
Raptors and Other Species
Ethics, Guidelines, Cascades Raptor Center
Coot and Eagle Brain Lesion Syndrome
Field Manual of Wildlife Diseases
Lead Poisoning of Eagles and Other Species
Flight Enclosures for Eagles
The Raptor Center, Univ. of Minnesota
National Wildlife Rehabilitators Association
Rehab Rules for Eagles, USFWS
Vet Tech Resources
American Eagle Foundation (The Great Seal)
The Great Seal
Viewing Eagles in Alaska
Viewing Eagles in Alaska (another site)
Viewing Eagles in Illinois, Illinois River
Viewing Eagles in Iowa, Red Rock Lake
Viewing Eagles in Kentucky/Tennessee Dale Hollow Lake
Viewing Eagles in Minnesota
Viewing Eagles on the Mississippi River
Viewing Eagles in Nebraska
Viewing Eagles in New York, Hudson River
Viewing Eagles on Reelfoot Lake, TN
U.S. & Worldwide Eagles
Crowned Eagles
General, AEBI
General, AEF
Harpy Eagle 1
Harpy Eagle 2
Philippine Eagle
Miscellaneous Birds, Endangered Species, Nature, Environment
Opportunities in Forestry
Global, WCMC
(World Conservation Monitoring Centre)
(U.S.Fish & Wildlife Service)
U.S. & Global, EE
(Environmental Education)
Children's Eagle Crafts
EE Organizations and Projects about Eagles
EE Organization Directory
Eagle Environmental Contaminants
Lead Poisoning
Concerns Arise Over Lead Impacts - National Wildlife Health Center
Helping America's Bird - Universiy of Minnesota Raptor Center
Get the Lead Out - Cornell Labs of Ornithology
Get the Lead Out - Center for Biological Diversity
Lead Toxicity in Bald Eagles - WHSV TV Interview with Wildlife Center of Virginia
How We Needlessly Poison Ourselves and Wildlife - Multiple Sources
Lead vs. Copper Bullets - National Park Service
Copper Bullet Testing 2011 - Institute for Biological Studies & National Park Service
Species Ingesting or Poisoned by Lead - Literature Review by Save Our American Raptors
Bad Shot - Audubon Magazine
Hunting Lead Free & Saving Wildlife - (Links to 14 Lead Impact References), Save Our American Raptors
DDT Impacts
American Bald Eagle - U.S. Fish & Wildlife Service
DDT and Birds - Stanford University
DDT - Journey North
Birds of Prey, AEF
Flight Enclosures for Raptors
Nest Box Designs and Backyard Birds
Raptor Species Links
Birds of Prey, OK
Raptor Facts, TRC
Birds of Prey Foundation
Raptor Research Foundation
AEF - American Eagle Foundation
BPF - Birds of Prey Foundation
INHS - Illinois Natural History Survey
LHFNAB - Electronic Book, "Life Histories of Familiar N. American Birds"
NFL - National Football League
NWF - National Wildlife Federation
NWRA - National Wildlife Rehabilitators Assoc.
NYSDEC - New York State Dept. of Environmental Conservation Endangered Species
PIF - Partners in Flight
RCAU - Raptor Center of Auburn University
RRF - Raptor Research Foundation
TRC - The Raptor Center, University of Minnesota
USFWS - U.S. Fish & Wildlife Service
USGS/NWHC - U.S. Geological Survey/National Wildlife Health Center
National Eagle Speakers Bureau
National Eagle Speakers Bureau
Eagle Exhibits in the United States and Canada
List of Eagle Exhibit Locations
Eagle Festivals & Events (U.S. & Canada)
Scout Patch (PDF)


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For most of us, it is so easy to get wrapped up in the business of everyday life.
We are all spread too thin, try to cram too much into a day, are too connected with our various technologies, and often are just too busy to stop and say "thank you" to those who mean so much to us.
During this Thanksgiving season, we should all stop and take a minute to reflect on all of the blessings that we have been given and to remind others just how important they are in our lives.Subscribe to Read!


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Promotional Holiday Music greeting cards are a great way for your company to join in on the holiday season festivities and show your clients that you care. Not only can you help customers bring in the mood of the holiday season, but you can also have your company name or logo imprinted on the CD casing and have a personalized message imprinted on the interior of the greeting card to improve your company's brand recognition.
The holiday season is an excellent time to make a huge impact on your clients. With a promotional holiday music gift your customers, clients and employees will know that you care about them and their business. A holiday music CD from your company will be a prized possession that they will listen to every year and fondly remember who originally gave it to them. Now that's high impact brand messaging!
These promotional holiday music greeting cards are a great way to say "thanks" during the holiday season. These cards are guaranteed to stand out from all the rest because they come with a holiday music CD and are custom printed with your business's logo and personal message. These greeting cards make a perfect gift on their own or in addition to another corporate promotional gift.
Choosing the right holiday gifts for your clients, staff and customers has never been easier. At ePromos we are passionate about promotional holiday music cards and gifts! We love helping our customers succeed by delivering great merchandise - at a great price. Whether you prefer to self-serve and find and order online or you want to chat with our Brand Consultants, we're here to help you. Just call us at 877-377-6667, chat, or email us.
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Text Me Cookie Gift Set
OMG! Send a sweet text message to your BFF!
Cookie Count: 7 hand-iced sugar cookies
Box Size: Single Layer Small Gift Box
Here at Eleni's New York, our custom cookies are delicious, adorable, Nut Free and Kosher! These decorative hand-iced cookies are gift packaged in our signature brown and pink Eleni's gift box, making it the perfect gift for any occasion.


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A classic cross design with blooming petals and sinuous arms, each extending out from a brilliant centered gemstone. See Details
Gemvara jewelry is truly personal: you design it, choosing gems and metals to celebrate your story, and we craft it just for you. We'd love to help you find your perfect piece! (more)What quality are your gemstones?
They are all-natural and hand selected fine quality. (more)


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LEGO Shop Home Themes Ninjago LEGO® Ninjago Key Chain Snake
- Exclusive
LEGO® Ninjago Key Chain Snake
- Item: 850443
- Ages:6+
- VIP Points: 2
- Sold Out
Sink your teeth into traffic with an authentic Venomari Warrior minifigure attached to a sturdy metal ring and chain!Price 6,90 SFr Sale Price 3,45 SFr
Bite into building with a Venomari Warrior!
Keep the venomous power of the Venomari tribe by your side with an acid green Venomari Warrior minifigure! Bring the epic LEGO® Ninjago battles with you everywhere. Includes an authentic LEGO Ninjago Venomari Warrior minifigure with accessories attached to a sturdy metal ring and chain.
• Features authentic LEGO® Ninjago Venomari Warrior minifigure with accessories attached to a sturdy metal ring and chain
• Attach to your keys or backpack!
• Minifigures are not detachable from metal chain
• Makes a great gift for fans of LEGO Ninjago building sets!
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We want to ensure that making a return is as easy and hassle-free as possible! If for any reason you decide that your purchase just isn't for you, simply return the item within 30 days of receipt and we'll cover the return shipping when you choose our FREE Pre-Paid Return Shipping Label. Learn more about our return policy.
Shop now and get Free Value Shipping on most orders over $29.95 to contiguous 48 states, DC and to all U.S. Military APO/FPO/DPO addresses.
If any of the information does not apply, do not fill out the corresponding fields of the form. Please contact us if you need help understanding or entering your prescription. Prescription eyewear guide.
Segment Height and Pupil Distance (PD) are required and must be measured specifically for the frame you are ordering if you desire perfect fit for your prescription eyewear. Contact us if you have not had these measurements taken.
Just Cavalli eyeglasses with your bi-focal prescription lenses make this pair of eyeglasses superior to many others because of its' extraordinary ability to give you a great feel and look. Different materials are blended into different colors so they may be suitable to a male and female public who want to be in line with the fashion trend. Just Cavalli Eyeglasses not only make you look great but offer a durable construction for your lifestyle in the fashion world.
See our Guide To Rx Glasses for information on how to order the Just Cavalli Rx JC 0461 with bifocals from our store. Contact Us if our eyewear experts may provide assistance with the Just Cavalli JC0461 lined multifocal glasses.
We, at OpticsPlanet, try to make it easy to order Bifocal Glasses on line by providing as much information as we can. See our detailed Rx information page that explains How to Read Your Eyeglass Prescription.
Available Just Cavalli JC0461 Rx Lens Styles:
These Just Cavalli Prescription Eyeglasses are also available as Just Cavalli Eyeglass Frames without prescription lenses:
Just Cavalli JC 0461 Eyeglasses frames without prescription lenses
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The Person Behind the Veil - Ministry Videos
Press the button below if you liked this video! Thank you! =D
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Posted By bethisraelwayne 2013-09-30T20:34:04
1844 The Person Behind the Veil.The ultimate treasure of the Holy of Holies, the ultimate point, purpose, and point of Yom Kippur -- and your life.
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UNIVERSITY OF WISCONSIN River Falls
At River Falls, our mathematics instruction is dedicated to nurturing and developing students' creative mathematical talents as problem-solvers. The River Falls mathematics faculty has diverse backgrounds and research interests, including combinatorics, differential equations, number theory, functional analysis, mathematics education, numerical analysis, probability, and statistics.
Students who major in mathematics at UWRF follow many satisfying careers. The UWRF mathematics minor is a excellent choice for students majoring in sciences, social sciences, business and education.
The Mathematics Department is arranged so that many faculty have study spaces directly outside their offices providing an environment of easy accessibility to professors. The department supports a Math Study Room where students work and informally interact with one another, and a Math Help Center which is staffed with upper level students who can provide help and insights to students studying mathematics in their first two years.
Professor Robert Coffman, Chair
Department of Mathematics
207 North Hall
Mail: 410 S. Third Street
River Falls, WI 54022-5001
Fax: 715-425-32O3


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In another attempt to debunk widespread belief that the world is coming to an end on Dec. 21, 2012, NASA has released a video intended to be aired on Dec. 22 -- confirming that life on Earth continues on.
The four-minute video titled "Why the World Didn't End Yesterday," labels the Dec. 21 Mayan apocalypse as a hoax and explains how the rumors began.
Earlier this month, the U.S. Government responded to apocalyptic fears by posting a blog on the USA.gov website to help dispel the rumors. The post touches on how many have been left frightened, especially children, some of whom have contemplated committing suicide because of the doomsday predictions.
NASA has also published a section on its site that provides answers for commonly asked questions and concerns about the rumored end of the world.
"The world will not end in 2012," NASA writes. "Our planet has been getting along just fine for more than 4 billion years, and credible scientists worldwide know of no threat associated with 2012."
For those who've wondered about the Mayan calendars abrupt end, NASA addresses that too.
"Just as the calendar you have on your kitchen wall does not cease to exist after December 31, the Mayan calendar does not cease to exist on December 21, 2012," NASA writes. "This date is the end of the Mayan long-count period but then—just as your calendar begins again on January 1—another long-count period begins for the Mayan calendar."
Click here to read more about NASA's response to all the doomsday rumors and why the world will continue on beyond 2012.
Stay Patched in, get the Peachtree Corners Patch free newsletter here.


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Labs at NIBIB
The Intramural Research Program plays a key role in fulfilling the Institute's mission, particularly to advance knowledge in imaging and bioengineering research using a combination of basic, translational, and clinical science and to develop effective training programs in related fields.
Scientific Program Areas
The NIBIB brings together the research communities of biomedical imaging, bioengineering, the physical sciences and the life sciences to advance human health by improving quality of life and reducing the burden of disease.
Learn more about the areas of research supported by the NIBIB
Featured Programs
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) supports a large network of Biomedical Technology Resource (P41) Centers. Scientists at these Centers ensure that biomedical investigators who have NIH-supported projects may gain access to the newest and most advanced technologies, techniques, and methodologies.
The purpose of the IMAG is to provide an open forum for communication among government representatives to share updates on individual programs from the various IMAG agencies, and to plan trans-agency activities that will have a broad impact on the communities served by IMAG.
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) created the Point-of-Care Technologies Research Network (POCTRN) in 2007. POCTRN's purpose is to drive the development of appropriate point-of-care diagnostic technologies through collaborative efforts that merge scientific and technological capabilities with clinical need.
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) established the Quantum Grants Program to make a profound (quantum) impact on the prevention, diagnosis, or treatment of a major disease or national public health problem through the development and implementation of biomedical technologies, within 10 years.


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- Make sure that you first cut your pubic hair with scissors to about a quarter inch. This will make the waxing much easier and less painful. By doing this you should not cut it to much because in that case the hair will be too short to stick to the wax.
- You have to soften the hair by using some moisturizer or lotion. It is similar to shaving and it will be much easier when the hair is soft. You can use any product which will fulfill this purpose.
- Make sure the wax is hot before applying. Of course, it should not be to hot because in that case you could burn your skin. You can heat it in your microwave. Different brands of wax can demand different ways of heating, but if you are not sure, first read instructions on the package. Also make sure that the temperature is adequate during the whole session.
- Apply the wax on the skin. This is the most important part and it is important to pull your skin as tightly as possible, spread the wax carefully in a thin layer. Then wait for about 10 seconds before you do the next step.
- The next step is to rip the wax off. It will be easier when you do this in the direction of your hear growth and when you rip small areas at a time. In that way you will get better results and it will be less painful.
- Use a mirror when waxing spots you can not see.
- After repeating these steps in order to wax the whole zone which you want to be clean of the hair, you can use some oil to moisture the skin and to remove any remains of the wax.
- Perfect your technique
Read more [...]


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Quick Links
Shop All Jewelry
Animal lovers and pet lovers, you'll simply adore our collection of Oriana animal beads! With frogs, pigs, dogs, ducks, and a farm's worth more of animals, you're bound to find at least one new companion for your bead collection!
For the animal lover in us all, these animal beads are the perfect way to create a unique piece of jewelry! From an elephant bead, to a penguin bead, to a turtle bead, to a golden fish bead- you'll be hard pressed to not fall in love with at least one of these animal charm beads!
Whether you're looking to celebrate a new pet, or just want a bead for your favorite animal, you'll love our animal beads. We have dog beads, cat beads, we even have monkey beads - our selection will drive you hog wild! So, whether you're looking to add some animal beads to your Pandora bead collection, or you want to start a new charm bead bracelet you won't believe the selection of animal beads that we have.
Fully compatible with Pandora beads, Chamilia beads, Biagi beads, Troll beads, and Pugster beads, you can create a bracelet all your own. Accent these lovely animal beads with some inanimate object beads, for a style that's truly you.


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Test Predicts Breast Cancer Recurrence Risk and Chemotherapy Benefit
Results from several studies presented last week at a major research conference validate that a new test can predict the risk of breast cancer recurrence in a sizable group of patients; the studies also appear to identify which of those patients will benefit most from chemotherapy. The studies were heralded by researchers as an important moment in the move toward individualized cancer care. Central to the investigations is a test, Oncotype DX, that analyzes the expression of a 21-gene panel in biopsy samples from women with estrogen-dependent, lymph-node negative breast cancer, which accounts for more than 50,000 breast cancer cases in the United States each year.
The results, presented at the San Antonio Breast Cancer Symposium, "are some of the most striking I have seen in breast cancer," said Dr. Jo Anne Zujewski, a senior investigator in the NCI Cancer Therapy Evaluation Program, during a news conference. Read more
A Year to Remember
We launched the NCI Cancer Bulletin this past January to better communicate the myriad activities that constitute the cancer research enterprise at NCI and beyond. Of course, no single publication can adequately capture the enormity of the work being done to defeat the malignancies that we collectively call cancer. Rather, our intention was to provide an authoritative voice that helps those who are committed to defeating cancer stay abreast of some of the most important NCI-supported activities that affect them or their loved ones.
And 2004 was the perfect time to introduce the Bulletin. We saw significant advances that spanned the discovery-development-delivery continuum of cancer research. New findings in the area of cancer imaging, for example, suggest that we are moving toward a time when we can use advanced imaging technologies to monitor cancer at the molecular level, measuring treatment effects before they are clinically apparent, thus making more timely treatment decisions. New insights into the metastasis process were also gained this year, with researchers elucidating critical activity in the tumor microenvironment that enables metastasis to occur. With the launch in October of the NCI Integrative Cancer Biology Program, we will move more quickly toward unraveling the complex processes that underlie tumor growth and metastasis. Read more
Test Predicts Breast Cancer Recurrence Risk and Chemotherapy Benefit
Results from several studies presented last week at a major research conference validate that a new test can predict the risk of breast cancer recurrence in a sizable group of patients; the studies also appear to identify which of those patients will benefit most from chemotherapy. The studies were heralded by researchers as an important moment in the move toward individualized cancer care. Central to the investigations is a test, Oncotype DX, that analyzes the expression of a 21-gene panel in biopsy samples from women with estrogen-dependent, lymph-node negative breast cancer, which accounts for more than 50,000 breast cancer cases in the United States each year.
The results, presented at the San Antonio Breast Cancer Symposium, "are some of the most striking I have seen in breast cancer," said Dr. Jo Anne Zujewski, a senior investigator in the NCI Cancer Therapy Evaluation Program, during a news conference.
Confirmation of earlier data on the ability of the assay - developed by Genomic Health Inc., which, along with NCI, funded some of the studies - to accurately predict recurrence risk was needed. What was lacking, some breast cancer researchers had argued,was data on whether the assay could forecast chemotherapy benefit, which would help guide treatment decisions.
An analysis of biopsy samples from patients in the tamoxifen plus chemotherapy arm of the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-20 study using the assay, Oncotype DX, appears to answer that question. According to the lead investigator, Dr. Soonmyung Paik, patients with high "recurrence scores" on the assay (31 or higher on a 0 to 100 scale) had a significant benefit from chemotherapy (27.6 percent absolute increase in distant relapse-free-survival at 10 years). Patients with low recurrence scores (18 or lower), on the other hand, essentially received no benefit from chemotherapy. According to these results, about one-quarter of patients with node-negative, receptor-positive breast cancer are at high risk for recurrence and would benefit from chemotherapy in addition to tamoxifen, while about half of patients are at low risk and would not.
"I think the data indicated clearly that the benefit of chemotherapy is not uniform," said NSABP Chair Dr. Norman Wolmark.
The presentation of these data coincided with the New England Journal of Medicine's online publication last week of results from the first large-scale study using Oncotype DX on archival samples from NSABP. These data were initially presented last year and showed that the actual breast cancer recurrence rate was 6.8 percent at 10 years in patients with low recurrence scores, 14.3 percent in the intermediate score group, and 30 percent in the high score group.
The Oncotype DX assay is considered a breakthrough because it can be used on tumor specimens that are fixed and embedded in paraffin. This has been technically difficult to do because RNA is altered when stored in this fashion. Researchers at Genomic Health Inc., however, developed a method for performing genetic analyses that allows them to use the altered RNA, making testing of patient samples readily accessible to clinicians in all settings. Currently, Genomic Health's California-based headquarters is the only facility licensed to perform the test.
NCI will conduct a randomized, prospective clinical trial involving all the clinical trials groups that study breast cancer. The trial will use Oncotype DX to identify patients with recurrence scores in the intermediate range to determine whether they benefit from chemotherapy. "That's the group for whom we really don't know how well this test will perform," Dr. Zujewski said.
A Year to Remember
And 2004 was the perfect time to introduce the Bulletin. We saw significant advances that spanned the discovery-development-delivery continuum of cancer research. New findings in the area of cancer imaging, for example, suggest that we are moving toward a time when we can use advanced imaging technologies to monitor cancer at the molecular level, measuring treatment effects before they are clinically apparent, thus making more timely treatment decisions. New insights into the metastasis process were also gained this year, with researchers elucidating critical activity in the tumor microenvironment that enables metastasis to occur. With the launch in October of the NCI Integrative Cancer Biology Program, we will move more quickly toward unraveling the complex processes that underlie tumor growth and metastasis.
Some of the most highly praised studies published this year highlighted how genetic mutations influence the efficacy of new targeted agents - findings that should aid the movement toward more individualized care and development of other targeted agents. Combined with improvements in the use of more standard therapies, such findings presage a cancer care revolution.
With the launch of the cancer Bio-medical Informatics Grid (caBIG) and the NCI Alliance for Nanotechnology in Cancer, we hope to rapidly accelerate the cancer research technology revolution. I am confident these initiatives will transform how we conduct research, allowing scientists to perform their work more quickly and develop more effective diagnostic tests and therapies. Such technological advances clearly will affect our clinical trial system, a fact being considered by the NCI Clinical Trials Working Group formed this year. The group is rapidly moving toward providing recommendations for the NCI-supported clinical trials program to ensure that it yields more efficient, informative trials that quickly translate into new interventions.
New reports released this year also shed more light on the factors that influence cancer care disparities and the problems encountered by and the needs of cancer survivors. More importantly, through the NCI Center to Reduce Cancer Health Disparities and Office of Cancer Survivorship, we are addressing these issues. NCI, for example, is funding radiation oncology clinical trials at institutions that care for a large number of medically underserved patients. NCI is also firmly committed to preventing cancer and recently launched, with HHS, a national network of smoking cessation quitlines.
All of these efforts will lead us to an era of personalized oncology in which we prevent more people from developing cancer, detect the disease very early, and successfully eliminate or control their malignancy. I hope these representative examples give you a sense of the work being done in the cancer research community and of where we are going as an institute.
I'd like to extend my most sincere thanks to all of you who participate in helping advance cancer prevention, detection, diagnosis, and care. Your efforts are important and inspiring. Have a safe and happy holiday season and my warmest wishes for a new year filled with health, success, and joy.
Dr. Andrew C. von Eschenbach
The Promise of Molecular Medicine Pushes U.S. Biorepositories to Network
"The tissue is the issue" say the experts, meaning that in order to conduct the discovery research fundamental to molecular medicine, it will be essential to have access to large numbers of high-quality, clinically annotated biospecimens. Around the globe, several countries are advancing toward large, networked systems to ensure that researchers have such access.
Advanced technologies such as genomics, proteomics, molecular imaging, and nanotechnology hold great promise for understanding disease at the molecular level. But experts note that progress in using these technologies to deliver new preventive, diagnostic, and therapeutic agents to cancer patients is hampered by a lack of cooperative infrastructure among institutions that collect, store, and distribute human biospecimens for research. "The need to align and optimize biospecimen resources in the United States is among the most critical scientific issues we face in the cancer research community," said Dr. Anna Barker, NCI deputy director for advanced technologies and strategic partnerships.
Human biospecimens - tissue, blood, urine, or other bodily materials - are critical for translating basic discoveries into new cancer interventions.
Biospecimens are collected for diagnostic procedures; however, material not used for patient diagnosis and care can be stored for research use with appropriate patient consent. Biospecimens are most valuable for research when they are annotated with detailed demographic, clinical, and longitudinal information that can be analyzed in combination with research results derived from analyses at the molecular level. Collections of biospecimens and associated data are called biobanks or biorepositories.
According to a report by the RAND Corporation, more than 300 million human biospecimens are currently stored in U.S. biorepositories. However, these biorepositories do not share common biospecimen standards and policies for quality control, data collection, ethical clearance, and access by the scientific community. "Given the variability in current procedures to collect, annotate, process, and store biospecimens, it is difficult for researchers to compare data derived from biospecimens collected at different institutions," said Dr. Julie Schneider, of NCI's Office of Technology and Industrial Relations. "Moreover, variations in informed consent processes hinder researchers' efforts to aggregate the large numbers of biospecimens typically required for high-throughput analyses."
NCI has been gathering input from its advisory boards on this complex issue. In addition, the future direction of biorepositories was discussed by representatives from the nonprofit, private, and government sectors, and by several international representatives at November's 2004 IBM Biobank Summit. Dr. Barker delivered the plenary lecture at the meeting, calling for participation, commitment, and leadership from the entire biomedical research community. "If we can solve this problem in a timely fashion," said Dr. Barker, "I think it will be a great advance for biomedical research and for the patients, who will be the ultimate beneficiaries."
The biospecimen networking concept is gathering momentum internationally, with several recently announced biobanking initiatives; NCI is planning to test several key biobanking principles within its integrated network of prostate cancer Specialized Programs of Research Excellence. In addition, NCI and the Foundation for NIH, which raises private sector funds for NIH biomedical research initiatives, are planning a demonstration project for a national effort that would collect, process, store, and distribute high-quality biospecimens from many cancer types.
"NCI has an opportunity to provide needed leadership in the area of biobanks and biospecimens and will continue to collaborate with all sectors and obtain grassroots input from the scientific community," said Dr. Barker.
Anastrozole Beats Tamoxifen as First-Line, Adjuvant Treatment
For postmenopausal women who develop hormone-receptor-positive, localized breast cancer, the standard adjuvant hormone treatment has been 5 years of tamoxifen. But new findings from the Arimidex, Tamoxifen, Alone or in Combination (ATAC) clinical trial have confirmed that the aromatase inhibitor Arimidex (anastrozole, developed by AstraZeneca, the sponsor of this study) provides these women with prolonged disease-free survival and a longer time to recurrence, as well as fewer treatment side effects. "Five years of anastrozole should now be considered as the preferred initial adjuvant endocrine treatment," the authors wrote in the December 8 Lancet.
After a median 68 months of follow-up, the data show that women who received anastrozole had a 26 percent risk reduction over tamoxifen in time to recurrence, and a 42 percent reduced incidence of contralateral breast cancer. The researchers noted that because their patients had a relatively good prognosis at the outset, it is too early to expect a difference in survival between the treatment arms, but with the additional finding that there were fewer participant withdrawals among those receiving anastrozole - perhaps due to the fact that patients receiving it had reduced incidence of endometrial cancer, blood clots, stroke, vaginal bleeding, hot flashes, and vaginal discharge - compared with those who received tamoxifen. "It is reasonable to switch patients currently on tamoxifen to an aromatase inhibitor," the authors wrote, and "the present data suggest that it is not appropriate to wait 5 years" before making the switch.
New Agent Proves Effective against Imatinib-Resistant CML
Patients with chronic myelogenous leukemia (CML) who had developed resistance to or were intolerant of imatinib (Gleevec) responded very well to a new investigational agent, BMS-354825, researchers reported last week at the American Society of Hematology (ASH) annual meeting. In the phase I study, partially supported by NCI, 86 percent of the 36 patients with imatinib-resistant, stable CML treated with the investigational drug BMS-354825 had a complete hematologic response, meaning that their white blood cell count returned to normal, for up to 9 months, with just a few patients experiencing minor side effects. Of the 29 chronic CML patients for whom the appropriate data were available, 28 percent had a major cytogenetic response, meaning the cancer-causing cells were eliminated. Positive results were also seen for study participants in the accelerated or blast phases of CML.
Although BMS-354825 and imatinib are targeted agents, the former is less selective. Both agents bind to the BCR-ABL tyrosine kinase, a mutated form of which initiates the overproliferation of white blood cells that eventually wreaks physiologic havoc. But BMS-354825 also inhibits another kinase that may be involved in imatinib resistance, SRC, and because it is less selective, can bind to other mutated forms of BCR-ABL that are at the root of imatinib resistance. In a study published in July in Science - led by Dr. Charles Sawyers from UCLA's Jonsson Comprehensive Cancer Center, one of the co-principal investigators of the study presented at ASH - BMS-354825 was effective against 14 of the 15 imatinib-resistant CML mutations tested (see July 27 NCI Cancer Bulletin).
Both Dr. Sawyers and co-principal investigator Dr. Moshe Talpaz of M.D. Anderson Cancer Center cautioned that these were preliminary results and that larger studies are needed to confirm the safety and effectiveness of this new agent. The drug's manufacturer, Bristol-Myers Squibb, announced during the ASH meeting that the company is moving rapidly to get the agent into phase II trials.Report Shows States Again Fail to Adequately Fund Tobacco Prevention
A Broken Promise to Our Children: The 1998 State Tobacco Settlement Six Years Later, finds that nearly every state is failing to provide adequate funding for tobacco control programs. The report, prepared by the Campaign for Tobacco-Free Kids, finds that in the current budget year only four states - Maine, Delaware, Mississippi, and Arkansas - are funding their tobacco prevention programs at or close to the levels recommended by the Centers for Disease Control and Prevention (CDC). While an additional 10 states fund tobacco prevention programs at about half the minimum the CDC recommends, the remaining 36 states and the District of Columbia provide less than half the CDC minimum, or provide no state funding whatsoever. All told, states spend $1 on tobacco prevention for every $23 spent by the tobacco industry to market tobacco products, despite receiving record levels of tobacco-generated revenue from the tobacco settlement and tobacco taxes. The Campaign for Tobacco-Free Kids is a coalition of more than 130 organizations committed to reducing tobacco use among both children and adults. Reflecting on the new report, Dr. John Seffrin, CEO of the American Cancer Society, stated, "This report shows a missed opportunity for states to save money and, more importantly, lives." The report can be viewed at http://www.tobaccofreekids.org/reports/settlements/.
Variations in state tobacco control funding and use of evidence-based interventions affect smoking prevalence and ultimately, smoking-caused disease. See the November 23 Director's Update in the NCI Cancer Bulletin for more information on a study of state-specific prevalence of cigarette smoking among adults.
Fifteen Contract Awardees Selected for Information Service
On December 7, NCI announced the selection of 15 organizations to operate its Cancer Information Service (CIS). The 5-year contract awards are anticipated to become effective Jan. 15, 2005, with a combined value projected to reach $20.9 million in the first year.
Located at medical centers across the country, these 15 regional offices will serve the United States, Puerto Rico, the U.S. Virgin Islands, and the U.S.-associated Pacific Territories. A complete list of awardees is available at http://www.cancer.gov/newscenter/pressreleases/CISAwardsRecompete2004.
The contracts involve three program areas: the CIS Partnership Program, CIS Contact Centers, and the CIS Research Program.
CIS Partnership Program
NCI will award 15 contracts to operate a regionalized CIS Partnership Program. Working together, CIS and its partners will reach those most in need of cancer information and services.
CIS Contact Centers
Four of the 15 organizations will operate CIS Contact Centers to provide information to the public by telephone and through LiveHelp, the instant messaging service accessible through NCI's Web site, www.cancer.gov.
CIS Research Program
All 15 organizations will participate in the CIS Research Program and will engage in cancer control, behavioral, and health communications research that supports NCI's priorities and programs. Four of the organizations were selected as coordinators of the Research Program.
"Advances in technology have enabled us to reduce the number of Contact Centers from 14 offices in 2004 to 4 offices in 2005," said Mary Anne Bright, CIS director. "This new configuration of 15 regional Partnership Program offices with 4 Contact Centers maximizes NCI's potential for preserving and enhancing trusted, long-standing regional partnerships."
Additional information about CIS can be found at http://cis.nci.nih.gov.
Community Participation in Research
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2464. Inquiries: Dr. Sabra Woolley - email@example.com.
Innovative Technologies for Molecular Analysis of Cancer
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2480. Inquiries: Dr. Gregory J. Downing - email@example.com.
Application of Emerging Technologies for Cancer Research
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2481. Inquiries: Dr. Gregory J. Downing - firstname.lastname@example.com.
Innovations in Cancer Sample Preparation
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2482. Inquiries: Dr. Gregory J. Downing - firstname.lastname@example.com.
Treating Mouth Sores in Pediatric Chemotherapy Patients
Name of the Trial
Principal Investigators
Why Is This Trial Important?
Mucositis (sores and ulcers in the lining of the mouth) is a common side effect of chemotherapy. This trial is testing a homeopathic preparation, called Traumeel S, as a treatment for mucositis in young patients undergoing chemotherapy in preparation for stem cell transplantation. High-dose chemotherapy and stem cell transplantation are frequently used in treating pediatric patients with leukemia or solid tumors. Traumeel S is a homeopathic remedy containing certain minerals and extracts from 12 different types of plants.
"An earlier study of Traumeel S conducted in Israel showed a significant reduction in mucositis among young patients undergoing stem cell transplantation," said Dr. Sencer. "With this trial, we hope to confirm those findings and therefore determine whether Traumeel S is an effective treatment for chemotherapy-related mucositis.
"There is a great deal of interest in complementary and alternative medicines among the public and studies have shown that our patients are using them," added Dr. Sencer. "We feel we have a responsibility to test these methods as rigorously as we would test any other intervention."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
NCI Announces Awards to Speed Cancer Biomarker Discovery
NCI announced last week that SAIC-Frederick, Inc., has made 2-year awards under a competitive solicitation totaling $13.4 million to 2 research teams from 10 cancer research institutions. The awards reflect a new collaborative approach to develop the standard tools and resources needed to accelerate protein biomarker discovery to provide new and highly specific approaches to the early detection and diagnosis of cancer. SAIC-Frederick is NCI's operations and technical support contractor in Frederick, Md.
The research teams will use transgenic mouse models of human cancers to study current proteomic technologies, compare results, and provide reference data sets and biological resources for widespread research use. This will enable comparability of results among laboratories currently using different proteomic technologies. The common data sets and resources will also make it easier to develop and test the next generation of biomarker discovery technologies. This framework will provide direction for the development of specific strategies to target biomarkers that signal the earliest stages of cancer in humans.
This 2-year effort will result in the first reliable and broad-based technological platform for the discovery and clinical validation of protein biomarkers for cancer. Information will be closely integrated and distributed through caBIG, an open-source, open-access, information network linking teams of cancer and biomedical researchers.
"Proteomics holds enormous potential for the early detection of cancer, but researchers must have standard reagents and reproducible technologies to accelerate the discovery and development of these biomarkers into clinical use," said NCI Deputy Director Dr. Anna Barker. "We believe that this unique network - with its teams of experts - will speed up the development of effective proteomic technologies for the benefit of cancer patients and their families."
One of the proteomics research teams is headed by Dr. Samir Hanash of the University of Michigan. Other researchers on the team are from Harvard-Partners Center for Genetics and Genomics, Massachusetts Institute of Technology, Dana-Farber Cancer Institute, Van Andel Research Institute, and Memorial Sloan-Kettering Cancer Center.
Drs. Martin McIntosh and Amanda Paulovich of Fred Hutchinson Cancer Research Center are leading the other proteomics research team, whose members include researchers from the Institute for Systems Biology, Pacific Northwest National Laboratory, and Plasma Proteome Institute.
Draft NIH Public Access Policy Elicits Comments
The draft policy requests, but does not require, that NIH-funded investigators submit electronically to NIH the final, peer-reviewed author's copy of their scientific manuscripts. The copy would be embargoed from release by NIH for 6 months after the publisher's date of publication. The copy would be publicly available in the National Library of Medicine's PubMed Central.
NIH developed the proposed policy and published it in the NIH Guide to Grants and Contracts and the Federal Register for public comment this fall. NIH received more than 6,000 comments and is in the process of reviewing them; a final policy is expected in the coming weeks. More specific information can be found at http://www.nih.gov/about/publicaccess/index.htm.
Input Needed on Future of Clinical Trials
President Nominates Leavitt to Lead HHS
On December 9, President Bush signed the Omnibus Appropriations Bill for fiscal year 2005. The FY 2005 amount for NCI is $4.866 billion, $141 million above the FY2004 obligations. However, one of the provisions within the Act is a 0.8 percent across-the-board reduction. The Labor/HHS portion of the bill is also subject to an $18 million reduction for administrative costs. Hence, the initial increase identified for NCI will be decreased. In addition, there are nondiscretionary obligations of the Institute that include the NIH policy to fund noncompeting Research Project Grants with an average 3 percent committed Cost-of-Living-Adjustment (COLA), a requirement for NCI to contribute to the NIH Roadmap Initiatives, and the mandated federal salary adjustment.
Therefore, to be able to continue our investments in strategic opportunities for the National Cancer Program, NCI leadership wants to discuss with the NCI community leadership the implication of budget allocations, including redeployment of existing resources to fund new opportunities. This will be discussed with the National Cancer Advisory Board, the Board of Scientific Advisors, the Board of Scientific Counselors, and the Advisory Committee to the Director at a retreat on January 11, 2005.


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