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Classic Garment Bag
best complemented withPrevious Page
Small Soft Travel Satchel
was: $295
Travel Kit
was: $95
Mobile Power Pack
Hanger Set
Passport Leather Cover
was: $75
- Tumi Accents
- Classic Garment Bag
- Style #: 22134AYT
- Free Shipping! See Details
Our signature garment bag for traveling professionals holds 3-5 suits or garments. Features numerous interior and exterior organizer pockets for folded clothing, shoes and accessories. Made from Tumi's tough ballistic nylon fabric. This item is part of the Tumi Accents program that allows you to add a touch of personal style and striking color to distinguish your selection. Simply choose one of the Tumi Accents colors and we will customize your item with the following embossed leather components: Tumi luggage tag, handle wrap, patch and zipper pull ties. A zip accessory pouch is also included.
- Monogramming Available: Yes
- External Dimensions (wheeled items include handles and wheels) H x W x D: 18" x 23.5" x 5.5"
- Expanded Depth: 41.5"
- Construction Material: Fabric
- External Features:
- Two U-zip pockets
- Flat zip pockets
- Back zip pocket
- Top and bottom carry handles
- Add-a-Bag sleeve
- Removable shoulder strap
- Internal Features:
- Garment curtain with zip pockets
- Removable laundry bag
- Shoulder pockets
- Garment extension/shoe pocket
- Universal hanger bracket
- Tie-down straps
- Hanging hook/pocket
Everyday Free Returns
We want you to be fully satisfied with every product that you purchase from www.tumi.com. If you are not satisfied with a product that you have purchased, you may return the product within 30 days of delivery for a full refund of the purchase price, minus the shipping, handling, gift box, and other charges. Please note, however, that monogrammed and personalized items, including Accent Your Alpha, cannot be returned. Return shipping is free. You will be provided with a pre-paid UPS domestic label to return your purchase. If you cannot find the prepaid shipping label, please call our Customer Service Department at 1-800-299-TUMI (8864) or contact us by email.
We ask that the product be unused, in original boxes (whenever possible), and with all paperwork, parts and accessories in order to ensure credit. Sale merchandise will be issued a credit at the current selling price. Unused items purchased on www.tumi.com can also be returned to a US Tumi full price location. Please make sure to have all paperwork, parts and accessories to ensure credit. Store credit will be issued for items without documentation.
Welcome to the world of Tumi – the finest international brand of travel, business and lifestyle accessories. Since our founding in 1975, Tumi has been dedicated to providing our customers with an outstanding ownership experience.
Specifically, we make three commitments to our customers:
1. You will enjoy using our innovative products that are designed and manufactured to be the best;
2. You will experience world-class, after-sales customer service;
3. For a limited time after you purchase a Tumi product from an authorized Tumi store or dealer, you will be covered by our Limited Warranty.
Tumi's warranty extends to the original owner; it is straightforward and comprehensive, and just part of the total Tumi ownership experience.
Please click here to learn more about the Tumi Warranty.
The Tumi Difference
Add-a-bag system
Quickly and easily add another travel piece or business case using our patented Add-A-Bag hook with secure fastened tab closure that holds in excess of 200 pounds. Also, many Tumi business cases and totes feature a back sleeve that slips over extended luggage handles allowing you to stack and carry heavier bags on your wheeled luggage. Used together, these features allow travelers to effortlessly carry two or three items at the same time with one hand.
Secure Slide® Shoulder Strap Attachment
Our exclusive, patented shoulder strap attachment design features a cover that slides into place to ensure that the clip stays closed securely. This feature eliminates the risk of bags accidentally falling from the shoulder strap and damaging the cases contents. It can only be opened manually when the hook is placed parallel to the strap attachment.
FXT Ballistic Nylon®
Tumi was the first to bring ballistic nylon to the consumer market over 30 years ago. Now we have perfected it with our exclusive FXT ballistic fabric, which combines a unique weave and a special coating to make it ultra-tough and virtually abrasion proof.
Tumi Patented Articulating Shoulder Strap
Move with greater ease with this patented design. The metal loop joints that attach the straps to the shoulder pad helps keep the bag from sliding off your shoulder as you move.
Tumi Tracer®
The Tumi Tracer® is an exclusive, complimentary program that helps reunite Tumi customers with their lost or stolen items. The core of the program is a unique 20-digit individual product number printed on a special metal plate that is permanently affixed to Tumi products. That number, along with the owners contact information, is entered into our Tracer database when a bag is registered with us, and used to help aid in the recovery of lost or stolen items that are reported to us.


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One-year-old Loghan Kaiser is battling a disease most of us have never heard of. "Retinoblastoma," said Erica Hammons, Loghan's mom. "They had to explain it to me because [I had] never heard of anything like that."It's a rare cancer that effects the retina -- the light-sensitive layer of tissue at the back of the inner eye. His mother and father, Sean Kaiser, knew something was wrong with Loghan very early on."You're holding your baby. You want to make the eye contact. He didn't make the eye contact," Hammons explained."He kind of always would look to the side, and as he got from a month closer to two months, his eyes started to jiggle kind of," Kaiser said. "I instinctively thought he was blind."Retinoblastoma can cause blindness, but that's what everyone is trying to prevent.
First doctors tried traditional chemotherapy -- powerful medication pumped into Loghan's body through an IV. For two joy filled months the tumors went away. "Exactly four weeks after the second month eye exam, his third month, they came back aggressive. They came back like really bad," said Hammons.Realizing the chemo wasn't working and radiation was too risky for a baby, Loghan's parents resorted to an experimental treatment that delivers chemotherapy right to the retina."They take the tube through the groin and put it through a main artery all the way up, and then that's when they spray the chemo in ... each eyeball," Hammons told us.It's called intra-arterial chemotherapy. It's risky and controversial, but the payoff could be huge."The doctors told me that this is, they call it a cure. They've got almost a 100-percent success rate with this for not only killing the cancer, but saving the eyes and keeping some sort of vision," said Kaiser.Loghan has to travel to New York for numerous treatments. So far he's had three and doctors are optimistic.
The family does not have to pay for the procedures, but for anyone who wants to help donate to help with the additional medical expenses, there is an Loghan Kaiser fundraising account at Chase Bank. You can also visit www.helpcurelogi.com.
WJBK-TV | Fox 2 16550 West Nine Mile Rd.Southfield, MI 48075Main Station: (248) 557-2000Newsroom: (248) 552-5103

subset: commoncrawl


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A collaborative model of maternity care between UCSF's certified nurse-midwives and obstetricians that began at San Francisco General Hospital almost 40 years ago allows each to learn from one another and practice to their unique strengths.
Latest News
December 26, 2013
September 24, 2013
In her annual State of the University address, Chancellor Susan Desmond-Hellmann highlighted UCSF's investments in its research, education and patient care to meet the challenges ahead.
June 11, 2013
Third-year resident Rhea Boyd, MD, and chief resident Jessica Schumer, MD, created a blog for the Department of Pediatrics to better understand the role social media can play in an academic medical center.
April 01, 2013
By providing scientifically based curriculum at after-school programs, UCSF helps kids learn how to manage their anger while excelling on the field and in the classroom.
March 25, 2013
Culturally sensitive communication is an essential piece of the core communications competency required of UCSF graduates, and Carol A. Miller, MD, works to help residents and medical students build those skills.
December 14, 2012
Following the tragic shooting at an elementary school in Connecticut, UCSF child-trauma expert Patricia Van Horn, JD, PhD, says parents should be honest with their children about what happened.
June 27, 2012
A professional drummer for more than 45 years, Grateful Dead drummer Mickey Hart and his band mates held a special performance for kids and their families at UCSF Benioff Children's Hospital.
May 04, 2012
Physicians at UCSF have access to a vastly expanded array of potential resources in their battle against childhood cancers now that they are part of an elite National Cancer Institute consortium of institutions selected to lead Phase 1 studies of potential cancer drugs.
August 12, 2011
UC scientists explain radiation risks from everyday background radiation, medical imaging and nuclear power plant accidents in the aftermath of meltdowns at the Fukushima Daiichi nuclear power plant in Japan.
June 20, 2011
UCSF family practice nurse Lisa Thompson is calling attention to the dangers of rustic stoves – which use biomass fuels such as wood, coal, animal dung and crop residue – and result in harmful pollutants adversely affecting people in developing countries.


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Size Guide
Sold out
5-pocket trousers in stretch twill with a regular waist and slim legs. (Blue/batik - each pair of trousers has a unique wash and look.)
2% elastane, 98% cotton.
Machine wash at 40˚
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Do you want Colorado stock photography to market your business? We can help you find just the right images for your project.
Hello, my name is Warren Diggles, the photographer behind Northern Colorado Photography. If you have any questions regarding licensing imagery you can send an email by filling out the form below. You can also call me directly at (970)412-0583.
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Contact Information
Warren Diggles
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United States
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Loveland, CO 80538
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If you think of it, please add my son, David, to your prayer list. He called a short while ago to tell me he had gone to the doctor today, and found out he has pneumonia. I feel so bad for him. He's had a rough go with way too many things ever since Christmas.
The last week of December he had terrible abdominal pain that was caused by a massive intestinal infection. They put him in the hospital for a week. It took five weeks for that to heal with strong meds. A colonosopy followed that, which revealed two polups and a cyst - which were removed successfully.
In mid-February he developed respiratory problems from allergies that required more strong meds.
In the last week of February his mom (Carol) was admitted into intensive care, where she died on March 1st. Of course, that entire week and the next week until her memorial service was very stressful for him.
Now, he has pneumonia and will need bed rest until that is gone.
His 43rd birthday dinner this weekend will need to be postponed for a while.


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|OTR Price
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|Combined fuel consumption (mpg)
|Power Output (HP)
|0-62 mph (secs)
|Dick Lovett Swindon
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As an Authorised BMW Dealer we offer the highest levels of service and expertise.
Our dealership showcases the latest new models, plus a wide choice of BMW Approved Used Cars. With highly trained technicians and a friendly, professional service, you can rely on us to maintain your BMW; keeping it in peak condition.
Rushey Park
Wootton Bassett Road


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Playskool Mr Potato Head Tater Tub
- In Stock
5 reviews
- Delivery
- Next day delivery available
With this great Playskool Mr Potato Head Tater Tub your child can have hours of fun creating silly faces and crazy designs!
This tub includes a Mr Potato Head, along with 16 different parts including eyes, mouths, arms, legs and accessories to create fun faces. Once they're done, it's easy to remove the parts and start again for hours of play.
All of the parts can be stored away in the tub to keep everything together, ready for the next playtime.
Useful info:
- Includes a Mr Potato Head body
- 16 parts and pieces
- Age from 2-5 years
- Playskool Mr Potato Head Tater Tub
Playskool Mr Potato Head
- In Stock
17 reviews
- Delivery
- Next day delivery available
This new look Mr Potato Head is perfect for little tots, providing hours of play.
He's sprouted new legs and comes with a range of mouths, eyes and accessories along with glasses and moustache so your child can create lots of different looks. Once they are done they can simply remove them and start again, or store them in the body to keep everything together.
A Mrs Potato Head is also available to keep him company, see item number 26XGV.
Useful info:
- New leg design
- Includes extra accessories
- Suitable for ages 2 and up
- Playskool Mr Potato Head
Playskool Pop 'n' Pick Elefun
- In Stock
2 reviews
- Delivery
- Next day delivery available
This Playskool Pop n Pick Elefun provides hours of unpredictable play as your little one races around collecting the colourful balls.
Your child will squeal with delight when they roll this adorable toy along as the bright coloured balls pop out of the trunk. They can then chase them around to quickly scoop the balls up in the elephant's feet, before starting the game all over again.
A fun way to improve youngster's coordination and teach them cause and effect. With a cute elephant design and bright colours it's sure to catch their eye, while also helping them burn lots of energy.
Once they're all tired out you can store the balls in the handle and the back of the elephant to keep everything together.
Useful info:
- Ball pop out of the trunk
- Roll over the balls to pick them up
- Balls can be stored in the handle
- Comes with 5 balls
- Age from 18 months
- Playskool Pop n Pick Elefun


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Sigma 521306 - 18-50mm - Sigma Lenses For Canon Mount - f/3.5-5.6 DC HSM Lens -Canon- (58mm)
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42nd Street Photo
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42nd Street Photo
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Mail Order Hours: Sunday - Thursday 10:00am -7:00pm I Friday 10:00am- 3:00pm EST. Saturday Closed.
NYC Retail Store Location: 378 5th Avenue Between 35th & 36th Street on 5th Avenue.
Retail Store Hours: Monday - Friday 9:00am - 8:00pm | Saturday - Sunday 10:00am 7:00pm EST. 1-212-594-6565.
Digital Camera Lenses
Sigma Lenses
Sigma Lenses For Canon Mount
Sigma 18-50mm f/3.5-5.6 DC HSM Lens -Canon- (58mm)
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Speck Grabber Cleaning Tool For Your Digital SLR Camera
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Sigma 18-50mm F3.5-5.6 DC zoom lens was exclusively for digital slr cameras
The image circle was designed to match the size of the image sensors of digital SLR cameras.
Sigma 18-50 mm has a variable angle of view of 76.5 degree - 31.7 degree.
Filter size 58mm.
Aspherical lenses provides correction for various aberrations throughout the entire zoom range and produce high level of optical performance.
Sigma 18-50 has a minimum focusing distance of 25cm (9.8 in.) at all focal lengths.
Capable of macro photography with a maximum magnification ratio of 1:3.5.
Equivalent to 27-75mm in 35mm format after 1.5x conversion factor.
Size: DxL 60mmx67.5mm/2.3 x 2.6 inches.
Weighs only 245g (8.6 oz.).
Lens Hood
Front and Rear Lens Caps
Carrying Case
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Tazo® Rococo Mug - Black, 16 fl oz
A 16-fl oz ceramic mug with Rococo-style elegance and a matte black finish.
- Product Details
Tazo® Rococo Mug - Black, 16 fl oz
Have more fun with your tea or coffee with this elegant ceramic mug with a Rococo-inspired vine-leaf handle. Designed exclusively for Tazo, the 16-fl oz mug has a matte black exterior and cream interior. Dishwasher and microwave safe.


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Directions to Hostel Hostel+
- Info
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Map & Directions
From the main railway station and bus arrivals:
By tram:
Take tram no. 2 and get off after six stations. Continue up the street and after 150 meters cross the intersection and switch to turn on the left. Here you enter Dalmatian street and go to number 3.
By Taxi:
Taxi should not cost you more then 400-500 din (�4 - �5). Don't take the taxis waiting in front of the station. Taxi driver must put the meter on.
From the airport:
Take the bus number 72 (ticket in the bus 100rsd/�1), and go to the final stop, Zeleni venac. When you get off the bus, take the stairs that are on the left side of the street. From there take the bus 16 or 95 and get off after two station. On the right side is Dzordza Vasingtona street; continue up to the street and after 250m start Dalmatinska street.


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Take on every day in the lightweight style and streamlined utility with the women's Burton Taylor Pack.
Get on-the-go accessibility from the simple main compartment, in a slimmed down volume that won't add bulk to your kit. A fresh envelope-style opening and fashion-forward fabrications like waxed cotton canvas with full grain leather round out this trim and sophisticated pack.
Scroll To Learn More
Design Features
- Volume: 13L
- Weight: 2.2lbs
- Dimensions: [14in x 13.5in x 2.5in]
- ** All Burton Bags are backed by a LIFETIME WARRANTY
Waxed Cotton Canvas / Full Grain Leather [True Penny Colorway]
600D Polyester x 1200D Polyester / Full Grain Leather [Ikat Stripe Colorway]
Polyester/Wool Blend and Full Grain Leather [Gray Wool Colorway]
Cush Ergonomic Shoulder Harness


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'Neverwinter' Coming to PC in 2011 from Cryptic Studios and Atari [Updated][Update: 10:30am] According to a GameSpot interview (as spotted by Shack user valcan_s), Neverwinter will "focus on cooperative play, requiring players to log into a server to start a session" encouraging play with others. Players will be able to play the game solo if they prefer but it will be "a much harder way to play." [Original: 9:25am] It looks like Dungeon & Dragons fans will be returning to the city of Neverwinter very soon.Atari has confirmed Cryptic Studios is currently developing Neverwinter, an "online role-playing" adventure based on the Wizard's of the Coast property and inspired by the upcoming book trilogy from author R.A. Salvatore. Previously, rumors had been circulating that Crypic had been working on a Neverwinter Nights-based MMO. Although today's announcement mentions online features, the game is not described as an online-only role-playing title. Shacknews has contacted Atari for clarification. [See update above.] The upcoming adventure allows players to select from one of five "classic D&D classes and team up with friends or computer-controlled allies to form five-person co-op groups." According to the announcement press release, players will also be able to create their own storyline and quests "utilizing an extremely user-friendly content generation system, tentatively codenamed Forge." Neverwinter is set to launch in Q4 2011 on the PC, alongside the aforementioned completed R.A. Salvatore book trilogy and a new tabletop role-playing game from Wizard's of the Coast. The first book in Salvatore's series, titled Gauntlgrym, is set to release on October 5 and will preview "the settings, characters and monsters from the PC game and details the events" that lead to the PC title's story.
Atari and Cryptic Studios Announce Neverwinter Coming in 2011 for PC
Storyline for new Co-Op Roleplaying Game Inspired by R.A. Salvatore's Upcoming Book Trilogy Los Angeles, CA (August 23, 2010) -- Atari, one of the world's most recognized videogame publishers and Cryptic Studios, the acclaimed developers behind City of heroes, City of Villains, Champions Online and Star Trek Online, announced today the development of Neverwinter for PC. Neverwinter is a new online roleplaying game based on Wizards of the Coast's global property Dungeons & Dragons and the beloved city of Neverwinter. Once a bustling location, Neverwinter has faced a great many disasters in the past hundred years. Rule of the city remains unclear following the unfortunate demise of the last Lord of Neverwinter and factions still battle for dominance after the all-consuming Spellplague took a high toll on the population. Even Neverwinter's dead are beginning to rise from their graves and march upon the city they once called home. "We're beyond thrilled to develop a brand new version of Neverwinter. It's been years since the original became a gaming icon and we're honored to work with such a great franchise," said Jack Emmert, COO of Cryptic Studios. "We've been working closely with Wizards of the Coast and R.A. Salvatore to create an authentic D&D adventure filled with compelling fiction and exciting gameplay." In Neverwinter, players choose to become one of five classic D&D classes and team up with friends or computer-controlled allies to form five-person co-op groups. Players also create their own storylines and quests utilizing an extremely user-friendly content generation system, tentatively codenamed Forge. "Wizards of the Coast is excited to invite millions of fans back to Neverwinter with the launch of R.A. Salvatore's Gauntlgrym," said Liz Schuh, Brand Director for Dungeons & Dragons at Wizards of the Coast. "And we're excited about the prospects for great digital gaming experiences based on this epic world." Neverwinter for PC is scheduled to release in Q4 2011 and is part of a multi-platform event, including a book trilogy from New York Times best-selling author R. A. Salvatore and a tabletop roleplaying game from Wizards of the Coast. Book one in Salvatore's Neverwinter trilogy, titled Gauntlgrym, releases on October 5 of this year and lays the groundwork for the Neverwinter storyline. The novel previews the settings, characters and monsters from the PC game and details the events that lead up to this highly anticipated PC gaming experience. To learn more about the game, please visit: www.PlayNeverwinter.com
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(based on 15 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Feels too small
Feels true to size
92% (12 reviews)
(12 reviews)
Feels too large
Most Liked Positive Review
I train in this belt 5 times a week. its got a great core its durable and it feels strong. the color is rich and true not to purple and not baby blue like...Read complete review
I train in this belt 5 times a week. its got a great core its durable and it feels strong. the color is rich and true not to purple and not baby blue like alot of belts ive seen. the only draw is its a little heavier from the center material. and its taking longer to break in then belts made more of pure cotton. but those are things i dont really care about. over all ill buy one of each color along my path in bjj.
Most Liked Negative Review
No thanks
I use this for Gi Jiu Jitsu classes. I got a size A2 gi that fits, but I got an A1 belt that looks like a cartoonishly long thing around my waist.
Reviewed by 15 customers
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Worth every $
By Rocknroller
from El Paso TX
About Me Competitive Athlete
Comments about Gameness Jiu Jitsu Belt:
Great quality material
Bottom Line Yes, I would recommend this to a friend
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Great belt
By Dude
from Cincinnati Ohio
Great Belt
Awesome Belt!
By JTPRIMAL
from Bossier City, LA
About Me Beginner
This is my first jiu jitsu belt and I love it. It works great and I will be ordering Gameness products from here on out (when it comes to jiu jistu).
Great belt.
By Throttle K
from Brookston, IN
High quality belt goes perfect with Gameness Gi. Wouldn't expect any less.
(0 of 1 customers found this review helpful)
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St. Mary\'s Fatheads
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Selenium and Vitamin E Fail to Reduce Prostate Cancer Risk
Participants in the largest-ever prostate cancer prevention trial are receiving letters instructing them to stop taking their study pills, the supplements vitamin E and selenium, after an independent review concluded that the trial will not meet its primary endpoint of reducing prostate cancer risk by 25 percent. The 35,000 participants in the NCI-funded Selenium and Vitamin E Cancer Prevention Trial (SELECT) are being asked to continue in the study for approximately 3 more years.
It is important to keep following SELECT participants for a number of reasons, explained Dr. Eric Klein, director of the Center for Urologic Oncology at the Cleveland Clinic and one of the trial's co-chairs. "There is a small chance of a 'lag effect' of one or both supplements, meaning that their impact on rates of prostate or other cancers may not be apparent for a few more years," he said.
The SELECT executive committee made the decision on the study medications based on the recommendation of the trial's Data Safety Monitoring Committee (DSMC). In its most recent review of the data in mid-September, the DSMC concluded that, with participants having been on their study medications for 5 years on average, there was little chance that one or both supplements would reduce the number of cases of prostate cancer. The review also revealed trends of increased prostate cancer risk with the use of vitamin E and increased adult-onset diabetes risk with the use of selenium, neither of which were statistically significant. Read more
Additional Genes Tied to Lung Cancer
A large-scale survey of genetic changes in lung tumors has identified 26 frequently altered genes in the most common form of the disease, lung adenocarcinoma. The discovery, reported in the October 23 Nature, increases the number of genes associated with lung cancer and expands the base of knowledge about the genetics of this deadly disease.
The Tumor Sequencing Project, a group of academic researchers funded by the National Human Genome Research Institute, analyzed more than 600 genes in 188 lung tumors for noninherited mutations as well as gains and losses of DNA. Their integrated analysis supports the view of cancer as a disease in which core biological pathways may be altered by various types of changes in multiple genes. Read more
Selenium and Vitamin E Fail to Reduce Prostate Cancer Risk
Participants in the largest-ever prostate cancer prevention trial are receiving letters instructing them to stop taking their study pills, the supplements vitamin E and selenium, after an independent review concluded that the trial will not meet its primary endpoint of reducing prostate cancer risk by 25 percent. The 35,000 participants in the NCI-funded Selenium and Vitamin E Cancer Prevention Trial (SELECT) are being asked to continue in the study for approximately 3 more years.
It is important to keep following SELECT participants for a number of reasons, explained Dr. Eric Klein, director of the Center for Urologic Oncology at the Cleveland Clinic and one of the trial's co-chairs. "There is a small chance of a 'lag effect' of one or both supplements, meaning that their impact on rates of prostate or other cancers may not be apparent for a few more years," he said.
The SELECT executive committee made the decision on the study medications based on the recommendation of the trial's Data Safety Monitoring Committee (DSMC). In its most recent review of the data in mid-September, the DSMC concluded that, with participants having been on their study medications for 5 years on average, there was little chance that one or both supplements would reduce the number of cases of prostate cancer. The review also revealed trends of increased prostate cancer risk with the use of vitamin E and increased adult-onset diabetes risk with the use of selenium, neither of which were statistically significant.
Launched in 2001, SELECT enrolled black men aged 50 or older and white men aged 55 or older - black men have a higher incidence of prostate cancer and are typically diagnosed at an earlier age than white men - to be randomized to one of four arms: two placebo pills, selenium and placebo, vitamin E and placebo, or vitamin E and selenium. Although several earlier laboratory and animal model studies suggested selenium and vitamin E had cancer prevention properties, the primary impetus for launching SELECT was the results from two cancer prevention trials in which each supplement alone seemed to significantly decrease prostate cancer risk. Neither of those trials, however, was focused on prostate cancer prevention, noted Dr. Laurence Baker, professor of medicine and pharmacology at the University of Michigan School of Medicine and chair of the Southwest Oncology Group, which coordinated SELECT.
So SELECT was launched, he continued, to definitively answer whether either supplement alone or in combination could reduce prostate cancer risk. At the more than 400 participating sites, participant enrollment was remarkably swift, with all 35,000 patients enrolled within 3 years.
The slight increase in prostate cancer and diabetes seen thus far could be "due to chance," stressed Dr. Scott Lippman, chair of the Department of Clinical Cancer Prevention at the University of Texas M.D. Anderson Cancer Center, and a co-chair of the SELECT scientific steering committee. This is particularly true for the prostate cancer trend. "There is no biologic rationale to suggest that vitamin E causes prostate cancer," he added.
In addition, noted Dr. Klein, the incidence of prostate cancer in the vitamin E/selenium arm was no different than for men taking placebo. "To explain this, one has to postulate that selenium cancels out any deleterious effect of vitamin E," Dr. Klein said. "This seems unlikely, given that selenium alone had no effect on the incidence of prostate cancer."
Ongoing analyses should help to clarify the findings, they said.
The published evidence for any connection between selenium and diabetes is mixed, so continuing to follow SELECT participants should provide some of the strongest evidence yet on the true effect of selenium on diabetes risk, Dr. Klein continued.
—Carmen Phillips
Additional Genes Tied to Lung Cancer
A large-scale survey of genetic changes in lung tumors has identified 26 frequently altered genes in the most common form of the disease, lung adenocarcinoma. The discovery, reported in the October 23 Nature, increases the number of genes associated with lung cancer and expands the base of knowledge about the genetics of this deadly disease.
The Tumor Sequencing Project, a group of academic researchers funded by the National Human Genome Research Institute, analyzed more than 600 genes in 188 lung tumors for noninherited mutations as well as gains and losses of DNA. Their integrated analysis supports the view of cancer as a disease in which core biological pathways may be altered by various types of changes in multiple genes.
For instance, more than two-thirds of the tumors had at least one mutation affecting the MAPK pathway. Lung cancer patients with these changes may benefit from drugs that affect this pathway, the researchers suggest, noting that compounds called MEK inhibitors have produced promising results in mouse models of colon cancer.
The findings complement other large-scale genomic studies, including an analysis of glioblastoma brain tumors by The Cancer Genome Atlas (TCGA) project that appears in the same issue (the findings were published online in September).
In both the lung and brain studies, new mutations were identified in some of the same cancer-causing genes, noted Dr. Matthew Myerson of the Dana-Farber Cancer Institute, who was a leader of both studies. The overlap suggests that despite the diversity of genetic changes in cancer, some targeted therapies will be effective in multiple tumor types, he said in a conference call with reporters. Current examples of such drugs include imatinib (Gleevec) and cetuximab (Erbitux).
Bevacizumab Tested as Imaging Agent
Combining a low dose of the anti-angiogenesis agent bevacizumab (Avastin) with a radioactive tracer may be an effective method for imaging tumors, according to findings presented October 22 at an international conference. In the study, Dr. Zheng Jim Wang and colleagues from University of Texas Health Science Center at San Antonio and MPI Research, Inc., used bevacizumab with the radioactive tracer copper-64 (64Cu) attached to it in mouse models of breast, lung, and pancreatic cancer.
The resulting tumor images, Dr. Wang reported at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Geneva, Switzerland, were superior to those obtained a day before in the same mice using what they said is considered "the gold standard" for tumor imaging - PET scanning with the imaging probe 18FDG. In addition, he noted, by using this combination as an imaging agent, the research team was able to detect tumors that were smaller and of an earlier stage than was possible with 18FDG.
The one-time administration of the compound uses a dose of bevacizumab that is 2.5 to 11.5 times less than the typical therapeutic dose given to patients. "Although we haven't pursued the dose-contrast correlation study yet, we believe there still is some room to decrease the [bevacizumab] dose and still achieve satisfying results for tumor detection," explained Dr. Wang.
Bevacizumab, which is approved in the United States for the treatment of advanced colorectal, breast, and lung cancers, targets vascular endothelial growth factor (VEGF), an important signaling protein that helps tumors develop the blood vessels needed to support their growth.
Stress, Depression Linked to Changes in Ovarian Tumors
Researchers have found that patients with ovarian cancer who experienced symptoms of depression and stress had elevated levels of an enzyme associated with the spread of cancer in macrophages, influential cells in the tumor microenvironment. The enzyme, MMP9, is a matrix metalloproteinase, which can induce cancer cells to invade and metastasize. The study included 56 women, and the findings appeared in the November 1 Clinical Cancer Research.
Dr. Susan K. Lutgendorf of the University of Iowa and her colleagues found that depressive symptoms, chronic stress, and low social support were strongly associated with increased levels of MMP9 in tumor-associated macrophages. Conversely, patients who had higher levels of social support had lower levels of MMP9 and VEGF, a growth factor that promotes the development of tumor blood vessels.
To look more closely at the mechanism by which these signals are elevated, the researchers exposed macrophages in vitro to hormones released during depression and stress, norepinephrine and cortisol, at concentrations similar to those found in vivo when a person is under stress. They found that this exposure increased production of MMP9 in the cells.
"These findings provide a new understanding of biobehavioral influences on the tumor microenvironment and may have implications for patient outcome and targeted pharmacologic and/or behavioral interventions for ovarian cancer patients," the researchers wrote.
Guest Update by Dr. Anna Barker
Oncology and the Physical Sciences Converge
Last week marked the third in a series of NCI-sponsored "think tanks" that I believe hold tremendous promise for advancing cancer research. These landmark meetings, "Physical Sciences-Based Frontiers in Oncology," bring together top scientists from physics, physical chemistry, engineering, mathematics, cancer biology, and clinical oncology to collaboratively identify the most promising research questions and strategies at the intersection of these fields that could enable progress in cancer research.
Over the last three decades, cancer researchers have made significant progress in beginning to identify important molecular alterations in cancer, and some of these alterations are pointing to new approaches that capitalize on advances in areas ranging from specific genetic targets to biomarker-driven diagnostic tests. Cancer research, more than any other area of science, is producing unprecedented quantities of data and pushing back frontiers in areas such as systems biology and the use of nanotechnologies to interrogate and deliver drugs to cancer cells. It is becoming increasingly clear that we must begin to understand the complexity of cancer in terms of the interactive physics, mathematics, chemistry, and engineering of these systems at all scales.
These workshops represent the next logical step in the process of moving toward an understanding of cancer as an emergent and complex biological system. Addressing questions such as: "How do cancers develop and evolve in three-dimensional space over time?" and "What are the mechanics of metastatic disease?" are the domain of the physical sciences. Scientists from these disciplines have a great deal to offer in the ongoing effort to understand how tumors develop, evolve, metastasize, respond, and become resistant to our therapeutic and preventive interventions.
During the first of these workshops, held in February 2008 with approximately 100 attendees, four major themes emerged which represent important focus areas for NCI:
This last area was the subject of last week's think tank. A range of experts in information theory, physics, engineering, and mathematics considered the processes of information management across scales (from the molecular level to the organism) and developed a number of innovative research directions that provide opportunities to view cancer as an emergent information-driven system. Intriguing questions such as "How do cells decide?" created new views of information transfer and cell signaling in cancer.
All of these think tanks have engendered a real sense of excitement among attendees, surpassing anything I have experienced in a long time. I think this excitement derives from looking at cancer through a different prism and perhaps thinking new thoughts about how to attack this complex group of diseases. I doubt that so many experts from these disparate and important fields have ever gathered with a single focus - to enable the development of this new frontier in oncology.
I suspect that when NCI launches a systematic effort to support such work, we will see many transdisciplinary research teams evolve to write a new chapter in cancer research. The convergence of disparate areas of science has often produced true innovation, and I anticipate that the same will be true for these new emerging fields of study focused on understanding and controlling cancer.
We plan on holding more workshops in this series next year, with the hope of making them regular events to bring together individuals interested in pursuing and supporting science in these evolving fields. I am confident that these activities will help us to deconvolute the complexity of cancer in ways that we can only dream about now, and they will lead to new generations of more effective cancer interventions.
Dr. Anna Barker
Colorectal Cancer Trials Support Gene Testing for Two Drugs
A trio of new studies adds to the growing evidence that patients with colorectal cancer should have their tumors tested for genetic mutations prior to starting therapy with cetuximab (Erbitux) or panitumumab (Vectibix). Tumors with certain mutations are unlikely to respond to the drugs, and these patients should be spared the expense and side effects of the medications, the findings suggest.
Cetuximab and panitumumab are monoclonal antibodies that inhibit the epidermal growth factor receptor (EGFR), which plays a role in multiple cancers.
The first new study was a retrospective analysis of the only cetuximab trial to show a survival benefit for patients with advanced colorectal cancer. In the CO.17 trial, the benefits of cetuximab were limited to patients whose tumors carried normal, or unmutated, forms of the KRAS gene.
As the researchers reported last year, the cetuximab group lived, on average, 6 weeks longer than those who received supportive care. But only some patients benefited, and to understand why, the researchers went back and analyzed tumor samples from 394 of the 572 participants.
Some clear patterns emerged: Among patients with normal KRAS genes, survival was nearly double for the cetuximab group compared to the supportive care group (9.5 months versus 4.8 months). The progression-free interval was also superior in the group of patients treated with cetuximab, 3.7 months versus 1.9 months.
Among patients with mutated KRAS genes, however, there was essentially no difference in survival between the two treatment groups, the researchers reported in the October 23 New England Journal of Medicine (NEJM). KRAS mutations were present in 42 percent of the tumors.
"These results represent an exciting transition in the treatment of cancer," said co-author Dr. Derek Jonker of the University of Ottawa. "Whereas in the past - and specifically in the CO.17 trial - we treated a large number of people and had a small effect, we now begin to have the ability to identify the patients who are most likely to benefit and then tailor treatment based on the unique genetic makeup of each person's cancer."
The research to date leads to the "reasonable conclusion" that all patients with advanced colorectal cancer who are being considered for anti-EGFR therapy should undergo KRAS testing, according to an accompanying editorial.
The clinical results are consistent with preclinical research on EGFR in colorectal tumors. The protein sits on the cell surface and controls a number of signaling pathways involved in cell growth. KRAS mutations can constitutively activate signaling pathways (for example, MAPK) normally controlled by EGFR. The researchers believe that because this activation occurs "downstream" of EGFR, drugs that inhibit the receptor will not affect the abnormal signaling.
Mutations in other genes, such as BRAF, may also impair the effectiveness of anti-EGFR therapy, the editorial notes. About 15 percent of colorectal cancers have disease-related mutations in the BRAF gene, which is part of the MAPK pathway.
A day after the NEJM study appeared, Italian researchers shared the results of another trial that showed that metastatic colorectal tumors with BRAF mutations did not respond to cetuximab or panitumumab. None of the patients with the mutations responded to these drugs, whereas all of the responders had normal BRAF genes.
The study included 113 patients, and KRAS mutations accounted for 30 percent of the non-responsive cases. BRAF mutations explained another 14 percent, leaving more than half of the nonresponsive cases unexplained.
Additional molecular markers will be needed to better define patients who are unlikely to benefit from EGFR-targeted treatment, said Dr. Federica Di Nicolantonio of University of Turin. She presented the results at the 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Geneva, Switzerland.
A third new study looked at the KRAS status of 715 patients in four panitumumab trials. None of the patients whose tumors had mutated KRAS genes responded to panitumumab (defined as tumor shrinkage or no tumor growth), compared with almost 14 percent of those with normal KRAS genes who did respond. Dr. Daniel Freeman of Amgen, Inc., the manufacturer of panitumumab, presented the results last week at the second EORTC-NCI-ASCO Annual Meeting on Molecular Markers in Cancer in Hollywood, FL.
During a press briefing, Dr. Bruce Johnson, director of thoracic oncology at the Dana-Farber Cancer Institute, said that the results were timely, important, and "quite
—Edward R. Winstead
Dr. Debra Silverman
Chief, Occupational and Environmental Epidemiology Branch,
When Dr. Debra Silverman caught her first glimpse of cancer research as a high school student in Brooklyn, she says, "It inspired something within me." Her Advanced Placement biology class - a program which was then in its infancy - took a memorable field trip to nearby Memorial Sloan-Kettering Cancer Center. While there, the group visited a lab conducting early animal studies of tumorogenicity of constituents of tobacco smoke.
"Cancer seemed like a great puzzle to me at the time. We understood very little about what caused it. Smoking was very prevalent," she recalls. "Early papers had come out in the 1950s about the connection between smoking and cancer, but the impact of that work hadn't taken effect. I really wanted to do something important in my career, and that trip planted a seed of interest in research that later circumstances allowed to grow."
Dr. Silverman continued to pursue that interest through college and graduate school in biostatistics, culminating with a doctorate in epidemiology at the Harvard School of Public Health, where she was one of the first non-M.D.s to complete the program and among the first women graduates.
Now an internationally recognized expert on bladder cancer, Dr. Silverman has co-authored more than 50 papers on the topic. Her early work provided the first national estimates of the prevalence of occupationally induced bladder cancer. She was also the first to demonstrate that truck drivers have an increased risk of bladder cancer, and she suggested that motor exhaust, particularly exhaust from diesel engines, may play a role in the development of the disease.
She was also a key contributor to research that documented for the first time the pattern of risk of bladder cancer following smoking cessation. Her most recent work suggests that increased urinary frequency and increased water intake have independent protective effects on bladder cancer risk.
Dr. Silverman leads two large studies of bladder cancer that are revealing new insights into environmental determinants, for example, components in drinking water like arsenic and disinfection byproducts.
In the 1990s, her studies of risk factors for pancreatic cancer solidified the evidence that cigarette smoking contributes to this disease. She was also among the first to suggest that elevated body mass index, history of diabetes, and hyperinsulinemia play an etiologic role.
One of her most challenging projects thus far, she says, is a 16-year study of the effects of occupational exposure to diesel exhaust on lung cancer risk in a cohort of more than 12,000 nonmetal miners who, because they work with diesel equipment in confined spaces underground, are exposed to diesel exhaust at levels an order of magnitude or more higher than those of other occupationally exposed groups. The study is expected to clarify the role diesel exhaust plays in lung cancer etiology.
Epidemiologic studies - whether in the occupational setting, such as the Diesel-Exposed Miners Study, or in the general population, such as the New England Bladder Cancer Study - are complex undertakings that often take a decade or more to complete. They involve state-of-the-art retrospective exposure assessment in the workplace and in the environment, in-depth interviews with participants, and the collection of biological samples from thousands of people.
"The methodologic challenges to studying occupational and environmental carcinogens require a huge commitment from the research team," she explains. "This approach exemplifies the complex, long-term studies that are hallmarks of the NIH intramural research program."
As chief of the NCI's Occupational and Environmental Epidemiology Branch, an appointment she received earlier this year, Dr. Silverman says she is excited to be leading the branch at a time when interdisciplinary research is becoming an increasingly important focus. In the era of genomic science, Dr. Silverman is championing the study of interactions between environmental/occupational hazards and genetic susceptibility. Her methodologic rigor in combining epidemiology, genetics, statistical analysis, and emerging technologies is one of the elements that make her so well suited for the job, says Dr. Joseph F. Fraumeni, Jr., director of NCI's Division of Cancer Epidemiology and Genetics (DCEG).
While carving out her reputation as an internationally respected epidemiologist, Dr. Silverman was able to raise two daughters, working part-time for many years. Juggling a scientific career with motherhood was a challenge, she says, and she now mentors many junior scientists who face the same work-life balance issues, a contribution for which she received the DCEG Mentoring Award.
"Cancer research is an extremely demanding career," she says, "but I think it's important for talented young women scientists to know it's possible to successfully balance a scientific career with the demands of raising a family."
—Eleanor Mayfield
Comparing Surgical Treatment for Small NSCLC Tumors
Name of the Trial
Principal Investigators
Why This Trial Is Important
Removing just a portion of the affected lung lobe (sublobar resection) has been shown in some nonrandomized studies to result in similar rates of survival as lobectomy for patients with small tumors (2 centimeters or smaller). However, these studies were not designed to prove definitively that sublobar resection is as good as lobectomy in patients with these small tumors.
In this randomized phase III trial, patients with stage IA NSCLC measuring 2 centimeters or less and located in the outer third of the lung are randomly assigned to sublobar resection (either wedge resection or segmentectomy) or lobectomy. The researchers will follow the patients for 5 years to compare how long they live without their cancer recurring (disease-free survival). They will also compare how long the patients survive overall, their rates of lung cancer recurrence, and their lung function.
"Current practice is based on research conducted in the late 1980s," said Dr. Altorki. "We think that several developments have changed the way we should treat these small tumors. We now have much better staging and can zero in on smaller tumors on the surface of lung segments.
"If the intervention is successful, this trial is likely to change the way lung cancer is managed surgically for years to come, and this will especially benefit patients who have comorbidities such as emphysema," Dr. Altorki added.
For More Information
An archive of "Featured Clinical Trial" columns is available at http://www.cancer.gov/clinicaltrials/ft-all-featured-trials.
Kington Named NIH Acting Director
Dr. Kington earned his undergraduate and medical degrees from the University of Michigan and completed his residency training in internal medicine at Michael Reese Hospital and Medical Center in Chicago. He attended the Wharton School of the University of Pennsylvania as a Robert Wood Johnson Clinical Scholar, earning his M.B.A. and his Ph.D. in health policy and economics.
Dr. Kington's research has focused on the role of social factors, especially socioeconomic status, as determinants of health. His current research includes studies of the health and socioeconomic status of black immigrants, differences in populations in willingness to participate in genetic research, and racial and ethnic differences in infectious disease rates.
SWOG Joins EDRN in Furthering Prostate Cancer Research
According to the proposal, all correlative studies involving biomarkers, at the concept stage, will come to the EDRN for review. This allows an opportunity to explore biomarkers that are not just diagnostic but also prognostic.
EDRN will use its secure Web site to provide online review and inform EDRN members of new concepts. If EDRN discovery and validation laboratories have a marker or technology that could be applied, they can contact the principal investigator of the therapeutic trial directly. The synergism between the two organizations will facilitate early identification of markers, modifications in trial design or study calendars, proper collection of specimens, recognition of any other preliminary data that are necessary to obtain, and, ultimately, a move towards individualized medicine.
Proposals Sought for 2009 NIH Director's Pioneer and New Innovator Awards
Pioneer Awards provide up to $2.5 million in direct costs over 5 years and are open to scientists at any career stage. New Innovator Awards provide up to $1.5 million in direct costs over the same period and are for early career investigators who have not received an NIH regular research (R01) grant or similar funding. NIH expects to make 5 to 10 Pioneer Awards and up to 24 New Innovator Awards in September 2009.
Beginning this year, both award competitions will begin with a pre-application phase. More information about the Pioneer Awards, including application instructions and submission deadlines, can be found at http://nihroadmap.nih.gov/pioneer. Information about the New Innovator Awards, including applications instructions and submission deadlines, can be found at http://nihroadmap.nih.gov/newinnovator.
A Shift in Strategy Needed to Win the Cancer Battle
In 1971 - one year after I became chairman of the Department of Surgery at Howard University - President Richard Nixon declared a national war on cancer. Since that time, the United States has invested billions of dollars in cancer research. The progress achieved in this area is a testament to the hard work and dedication of many researchers and health care professionals. Because of their efforts, many who face the diagnosis of cancer can be offered more hope than in years past.
However, cancer continues to impose a tremendous burden. Each and every day, 4,000 Americans are told they have cancer and an additional 1,500 lose their battle with this cunning enemy. Indeed, each cancer-related death should be viewed as a lost battle, a failure in the war we committed to winning so long ago.
In 2007 and 2008, the President's Cancer Panel heard from experts working in all areas of the National Cancer Program and concluded that a shift in strategy is needed. The Panel's recommendations, summarized below, are detailed in Maximizing Our Nation's Investment in Cancer: Three Crucial Actions for America's Health.
First, preventing and treating cancer must become a national priority. The National Cancer Program requires strong leadership from the highest level, beginning with the President of the United States. Support for cancer-related research must be strong and stable. Importantly, the emphases and design of our research programs must be carefully evaluated to ensure that our investment will translate into real progress in our clinics and our communities.
Third, the scourge of tobacco in America must end. Although the destructive effects of tobacco on health have been known for decades, it continues to be the leading cause of preventable death in the United States. Ridding the nation of tobacco is the single most important action needed to dramatically reduce cancer-related morbidity and mortality. Energetic efforts in this area are particularly critical in order to oppose the massive, unrelenting onslaught of tobacco industry marketing and product development.
Cancer is a complex enemy; however, we cannot allow ourselves to become complacent about the suffering inflicted by this disease. Rather than being content with incremental progress, we must harness the collective will of our leadership and our nation to create a cancer-fighting enterprise capable of achieving significant and rapid reductions in cancer morbidity and mortality.
Dr. LaSalle D. Leffall, Jr.


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Finding your keys is the least of your worries when you can't even remember where you parked the car. But did you know that working memory is also the basis for intellect? Build memory skills (and intellectual clout) with games, software, books and more.
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Don't let the
tattoos and crazy outfits scare you away! Roller Derby is an amazing way to
stay in shape and have fun doing it!
If you live in or near Sioux Falls, SD-see what Derby is all about! Join the FREE Sioux Falls Roller Dollz Boot Camp!
5 Health Benefits to Roller Derby
Roller derby requires athletes to build their strength and stay fit
Roller derby is an intense and demanding sport. Athletes who want to participate in roller derby have to make an effort to build their strength and stay in shape. Roller derby can be a very demanding and fast paced sport. For someone who isn't in shape, roller derby could be brutal. Because of this, athletes need to spend a lot of time stretching and performing strength building exercises in order to improve their performance on the track, as well as to increase their stamina and endurance.
Nearly every sport works out some muscles. Some sports work particular muscles more so than others. Roller derby, however, is a full body workout, using all of the major muscle groups. There aren't many sports that work all of the muscles groups so well, so roller derby is a good one to increase tone and build muscle all throughout the body.
Roller derby burns some serious calories
Roller derby is a very intense sport to participate in. Because of the demanding physical requirements of roller derby, the body burns more calories. This quick calories burning can be great for athletes who are looking to tone up, get rid of fat, or lose some weight. Just an hour of rollerskating can burn 300-500 calories depending on a person's weight. Roller derby is likely to burn even more calories than just typical rollerskating because of the increased physical demands and speed of the sport.
Roller derby is good for mental health
Roller derby, like most physical activity, signals the body to release endorphins. Endorphins could be thought of as the body's own natural anti-depressants or feel-good hormones. These endorphin rushes are often referred to as a "runner's high," but can result from nearly any type of sport or physical activity. Roller derby has an edge on just running or skating though. Roller derby is competitive and can give athletes frequent adrenaline rushes as they compete, something many athletes love.
Roller derby is a good aerobic workout
Participating in roller derby gives athletes a great aerobic workout, improving the strength and condition of the heart and lungs. While working out, roller derby athletes are able to get their heart pumping and their circulation flowing especially well, all of which can promote better overall health and wellness. Better heart and lung function is a benefit every athlete can enjoy.


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The attached chart shows how the growth of Chinese reserves has decelerated dramatically over the last five years and is now close to zero.
The chart was put together by Russell Napier, a consultant with stockbroker CLSA Asia-Pacific Markets, and the author of a course at Edinburgh Business School called a Practical History of the Financial Markets.
Napier said of the graph: "It is the most important chart in the world. The growth in Chinese reserves has determined all the key developments in financial markets in the last two decades. It printed lots of currency and artificially depressed the US yield curve. It has been the cornerstone of global growth, and now it's over."
The last time the Chinese reserve growth rate was below 10% was at the end of the 1990s, just before the bursting of the technology stock market bubble and a recession. The recovery in the growth rate from 2001 onwards was followed by the economic boom of the last decade. The growth rate turned down decisively in 2007, just before the onset of the financial crisis.
China's reserves have come from a trading surplus, and the Chinese authorities have used the money to buy US Treasury bonds. The finance that China supplied to the US helped fuel economic growth in that country and the rest of the world.


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PUMA's Autumn-Winter 13' sport heritage products serve as a source of inspiration to up-and-coming artists and entertainers. This season, PUMA reveals the Brand's Lifestyle Collection Directors: a collective group of influencers who connect culture, attitude, and style with ambition. Sought out from the streets of Paris, Los Angeles and New York City, PUMA's global group of Collection Directors have been assigned to enhance PUMA's seasonal key products with their creativity, vision and passion under the 'Next Starts Now' platform. The first of the Collection Directors to be introduced this month is Illustrator, Designer and self-proclaimed 'Bun' Queen, Sophia Chang.
NYC-born and bred, Chang's enthusiasm for killer product designs and POP culture was infectious for her first collaboration with PUMA. Tasked to visually reinvigorate the season's Women's Lifestyle Footwear collection, Chang and her dream team of talents, used the city streets of LA and New York as her backdrop for a photo-shoot that was remarkably colourful, spontaneous and empowering just as the collection itself.


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A Southfield woman made an agreement to have some work done at her home. She says a check has been cashed, but nothing has been done.Connie McCabe spoke to Mark Juncaj at a vendor table at the Novi Home and Garden Show at the Suburban Collection Showplace in February. McCabe wanted her Southfield home spruced up. She said Juncaj set up an appointment for an estimate at her home in April."Walked the whole yard with us and said we can do this, we can do that. We'll power wash. We're going to do all the caulking. We can replace these boards. We can power wash this. We can seal it for you because it's a hazard," she said.McCabe's deck needed some TLC, and Juncaj said he was the guy for the job. Home repairs and power washing for a price."He said to me, 'You'll be done by May 15,' but he said, 'I'm going to go ahead and put the 31st, but you'll be done,'" McCabe explained.The check was cashed, but no one came to the house to do the work. Not one board has been replaced on McCabe's deck, no paint, no power washing and no progress."My last communication with him was if you're not at least here or responding to me by the 15th, I want my money back because he insisted on half down, and he couldn't take a credit card. He said He didn't have the equipment for credit cards. It would either be cash or check. The check was cashed immediately. We wrote a check for $1,375."She filed a report with Southfield police. They are investigating. There is also another complaining party in Clawson. Kathy said she paid Juncaj $450 for work on her home, which she says has not been done.The Novi Home and Garden Show told me Juncaj will never be allowed back into another show as a vendor."I was concerned that other people were being taken advantage of. I'm retired and I saved for this project, and I'm really heartsick," McCabe said.Juncaj called me. He would not agree to do an interview. He did offer to pay McCabe her money back, but he asked me to give him her phone number. He said he hasn't been able to reach her.
UPDATE 6/3/13: Ron Savage reports Juncaj has refunded McCabe her deposit in full. McCabe got a bank check from an unidentified woman delivered to her personally outside the Southfield police station the morning of June 3.
FOX 13 / WTVT-TV3213 West Kennedy Blvd.Tampa, Florida 33609Main: (813) 876-1313Newsroom: (813) 870-9630Fax: (813) 871-3135


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Statistical Supplement to the Federal Reserve Bulletin
The Statistical Supplement to the Federal Reserve Bulletin is a continuation of the Financial and Business Statistics section that appeared in each month's issue of the Federal Reserve Bulletin. The Supplement was published monthly, January 2004 through December 2008. The majority of data published in the Statistical Supplement are continued on the Federal Reserve Board's website at www.federalreserve.gov.
2004 to 2008
Reserve Requirements of Depository Institutions
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January 2004-December 2004 (440.0K)


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A while back, I cooked a pound of dried black beans in my pressure cooker. I froze some of the leftovers in 1 cup batches so I could make a quick meal for myself in the future. To make this soup I sauted 1 onion, 1 green pepper, 3 cloves garlic along with some spices in cooking spray, then added the beans, veggie stock, salsa and 1 chipotle pepper. I brought this to a boil for several minutes. Next, I added around 2 c of cilantro and pureed the soup. To finish it off, I juiced an orange and a large lime and topped it with tofu sour cream and 1 t EVOO. Perfect to warm me up in this cold weather!
The veggies were zucchini spiralized, mushrooms, onions and garlic sauted in cooking spray. I added a lot of spices and crushed red pepper flakes. The sauce was silken tofu based. (I only like the silken tofu from Trader Joes. It is not chalky tasting to me like the boxed and other brands)
To the tofu I added some umeboshi vinegar, nutritional yeast, garlic and veggie stock along with just a TINY bit of smoked paprika and salt to taste. I topped each serving with 1 t EVOO.
I've also been eating a lot of salad with my very low fat balsamic flax dressing.
I am STILL waiting for my Vita Mix part. I MISS it sooo much.
I haven't had a green smoothie for over a week! wow... what a treat it will be to actually have one again. Also, many of my cooking projects are on hold.
Come on Vita Mix people! Get me my part!!! I NEED it!!!


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Four Webster Parish teams make the cut
The LHSAA basketball playoff pairing were announced Thursday, and four Webster Parish teams will be taking part.
The Minden High Crimson Tide, the North Webster Knights and both teams from Doyline. The Minden High Lady Tiders just missed the cut as the #34 team in the girls' 4A Power Rankings.


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Enjoy some of the best online Weather Forecasting Tools by downloading the WeatherBlink™ toolbar! Get instant FREE access to many excellent weather tools including 5 and 10 Day Forecasts, Today's Local Weather, Severe Weather Allerts, Weather News and even Allergy Reports! There are so many great online weather tools - the weather toolbar puts them all in one great place. With the WeatherBlink™ toolbar you will be able to access all these great weather tools with simple one-click access. Best of all - it's FREE!
Free Download - it's Free!
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Slim Fit Short Sleeve Linen/Cotton Yarndye Stripe 2 Pocket Shirt
Item# CFSW0130DS
Color :color
Size & Fit Size :size
Availability :
Find our guayabera's inspiring? So do we. Just check out our Slim Fit Short Sleeve Linen/Cotton Yarndye Stripe 2 Pocket Shirt for a modern spin on a classic style. The plainweave fabrication utilizes a linen/cotton blend for a great feel, while the slim fit, pointed collar, front tucking, double chest pockets and color options like Golden Earth and Scuba Blue combine to great contemporary casual effect.
- 55% Linen/45% Cotton
- Plainweave Fabrication
- Short Sleeve
- Point Collar
- Double Chest Pockets
- Front Tucking
- Slim Fit
- Machine Washable
- Imported
Rated 5 out of 5 by 1 reviewer.
Rated 5 out of 5 by NPT very nice Fits well and the fabric feels great. Haven't washed it yet but very happy with my initial impression. June 5, 2013
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Nike LunarGlide+ 4 Shield Women's Running Shoes
The Nike LunarGlide+ 4 Shield Women's Running Shoes offer the same ride you love but with Flywire for an adaptive, secure fit. Plus it's lighter than before! Flywire on the mesh upper adjusts through the laces and wraps the midfoot and arch for a personalized fit. Plus, shield technology adds a water-resistant layer for protection against wet weather conditions. An inner sleeve wraps around the entire foot for a plush fit, and it makes it easier to get the shoes on and off. Dynamic Support in the midsole adds stability without adding weight, plus a floating heel-support clip moves with you to keep the back of the foot from rolling. Increase your visibility with reflective elements, making it safer to run when light is low. Gain a smoother, more efficient stride with deep flex grooves in the sole of the women's shoes. Nike+ ready.
You may also like
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Men's Nike Air Max Tailwind 6 Running ShoesWas:
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Delivery and returns
Collect in store
- Free next day delivery to store is available on certain products if you place your order by 5pm. Your order will normally be available for collection from 12pm (noon) the next day.
Exclusions apply
- Service terms may be amended during peak periods or sales. Please ask in store at the Customer Order point or see marksandspencer.com for full details.
- NEW Next day home delivery* order by 10pm
- FREE Home delivery (within 5 working days) when you spend over £50
- Home delivery (within 5 working days)
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- More about your delivery options
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- *Products are subject to availability. Please note some of our products may be sent from multiple warehouse locations and therefore some of your order may not be available for next day delivery. If this happens, we will simply hold back your order to the next available day.
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- International delivery to 30+ destinations, from
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- It's free to return your order to most of our UK stores (excluding Outlet, Simply Food and stores at service stations, railway stations and airports).
- Or you can post it back to us for free within the UK using the pre-paid label that came with your order.
- Some items, like bedding, lingerie and swimwear, can't be returned once the original packaging, tags and hygiene seals have been removed. This does not affect your right to return faulty goods.
Size guide
Use our handy measurement charts to find the right size for your perfect style.
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measure around the base of the neck where the collar sits.
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measure the chest at the fullest part, placing the tape close up under the arms.
(c) Waist:
measure the natural waistline.
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measure from the crotch to where your trouser is normally worn on the shoe.
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measure from the centre back of your neck to your hemline. Then length measurement will vary depending on the style of garment.
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For a practical purchase that will remain stylish year after year, choose this parka. Made from luxurious Italian fabric and crafted with the panache typical of Italian designers, this carefully-tailored coat is a long-lasting investment piece.
- Product Shape: Single breasted
- Product Length: Above the knee
- Fit: Regular fit
- Fastening: Button fastening
- Lined
- Neck Shape: Funnel neck
- Number of Pockets: Two
- Lightly padded
- Detachable collar
- Notch lapel
- Long sleeve
- Zip fastening
- Textured finish
Care and composition
- Composition
- 40% cotton, 35% wool, 17% polyester and 8% polyamide
- Body lining- 55% polyester, 45% viscose
- Filling- 100% polyester
- Sleeve lining- 76% polyester, 24% viscose
- Inner jacket- 100% polyester
- Care instructions
- Dry clean


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MADISON, WI (WTAQ) - One Powerball ticket sold in Wisconsin was good for a million dollar prize.
It wasn't the jackpot of $588 million, but Dennis and Mary Retterath came to the Wisconsin Lottery headquarters in Madison Friday to cash in.
After taxes, the West Allis couple received $672,500.
Retterath says she bought the Quick Pick ticket at a Speedway in West Allis.
The ticket matched all five regular winning numbers, but missed on the Powerball.
Retterath and her husband will be at a news conference Monday at City Hall in West Allis.
A Missouri couple has claimed half of the big prize. The other half goes to whoever has the other winning ticket. It was sold in the Phoenix area.


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Each year the Best Global Brands generates increasing amounts of interest from companies and practitioners associated with brands.
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Thinking of moving to Israel? Here's all the information you need for a successful homecoming.
Aliyah Services
For people moving from:
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First Steps Aliyah Benefits Getting Ready In Israel Online Form
The Global Service Center: Aliyah and Israel Experience Hotline
Aliyah Programs
Young Aliyah
18-35 years-old and interested in making Israel your home? We offer specialized aliyah absorption programs designed to help young olim and students take their first steps to a lifetime in Israel.
Ease into your absorption by learning Hebrew at your level while connecting with other olim, enjoying cultural events and trips around Israel.
Absorption Centers
All your needs as a new oleh are taken care of in this unique Israeli housing arrangement, which serves as your first home from which to start the integration process.
First Home in the Homeland
First Home in the Homeland provides your young family with a warm home on a kibbutz for your first 6 or 12 months in Israel.
At Home Together (Babait Beyachad)
The At Home Together program recruits volunteers from the native and immigrant Israeli population to assist the integration of new immigrants from all over the world into Israel.
Global Service Center
The Global Service Center is our one-stop Aliyah and Israel Experience Hotline, open 22/6, in seven languages.
Aliyah of Rescue
For more than 65 years, The Jewish Agency for Israel and its partners have kept an unwavering promise to the Jewish people: to bring any Jew, from anywhere in the world, to safety in Israel.
Ethiopian Aliyah
Since the early 1950s, The Jewish Agency has assisted more than 40,000 Ethiopians with their immigration to Israel.
UlpanYoung AliyahKibbutz Ulpan
Interested in learning Hebrew while living on a kibbutz? Volunteer in a unique collective setting and experience life unlike anywhere else!
South Africa Israel CentreAliyah from South Africa
Are you considering making Aliyah?
Meet Our Staff
- "I myself made Aliyah in the 1980's, and I am full of gratitude for the continued work and commitment of The Jewish Agency" – Vered Achihon, Content Director, Ethiopian ProjectContent Director of "Ethiopian Project", earned her BA in Communications and her MA in Government Management from Haifa University. Vered made Aliyah when she was only 4, on The Agency's Operation Moses, arriving in The Jewish Agency absorption center in Atlit. In her current position, she now oversees for the absorption needs olim various programs, preparing a smooth integration into Israeli society and life.
- "I am currently writing a children's book that I always dreamed of publishing before the age of 35" – Omer Givati, Director of the Kiryat Gat-Lachish-Shafir-Chicago PartnershipOmer holds a BA from the Hebrew University in International Relations and Political Science, and met his wife while an emissary in USA. He won the President's Award for his work with Ethiopian immigrants. As a Partnership Director, Omer is responsible for the connections with the communities, educational projects and supporting local voluntary organizations.
- "After coming to Israel on The Jewish Agency's "Operation Moses", I'm now privileged to make the dream of return to Zion come true for so many others" – Asher Seyom, Emissary to Ethiopia– emissary to Ethiopia, joined The Jewish Agency as an educator at the Ben-Yakir Youth Village and later as Director of the Meron Absorption Center in Sefad. Following the Second Lebanon War, the Center was awarded most outstanding center for its treatment of olim in general and in time of war specifically.
- "My Masa program was a test drive which reinforced my long-time dream – to make Aliyah" – Rina Barats, Graphic Designer, Marketing UnitRina Barats, a graphic designer in The Jewish Agency Marketing Unit, emigrated from Latvia in 2012, and graduated from Hebrew studies in Ulpan Etzion. Rina designs marketing materials for the various content units and programs. She earned her BA from Latvian Academia of Culture, and participated in Taglit in 2009 and Masa, where she interned in graphic design in an Israeli startup company.
- "It's an amazing opportunity to provide young Jewish campers and counselors with the same life-changing experience that I had" – Daniel Mahrer, Shlichim and Camps Coordinator, Summer Shlichim (emissaries) ProgramDanielle Mahrer works as a Shlichim and Camps Coordinator for The Jewish Agency's Summer Shlichim (emissaries) Program, sending shlichim to summer camps in North America. She grew up in Los Angeles and studied History and Jewish Studies at the University of California. She spent summers at URJ Camp Newman, as a camper, counselor, advisor and Unit Head. Her first trip to Israel was on Taglit-Birthright, and she later studied at the Hebrew University in Jerusalem after making Aliyah in 2010.
- "My work is extraordinarily satisfying, enabling me to contribute to Israeli society and the Jewish people" – Yael Toledano, Senior AssistantYael Toledano has been working for The Jewish Agency in various capacities since 2006. Originally from the French village of Saint-Quentin, she grew up in Paris, before her family made Aliyah. Soon, Yael will start a new journey as The Jewish Agency long-term emissary to France, working with and for the Jewish communities to connect them to Israel, its history, culture and the Jewish spirit.
- "My work provides a wonderful opportunity to develop Aliyah programs that serve the interests of both Olim and Israel's economy" – Bilana Sahar, Director, Aliyah and Experience Israel, FSU unitBilana Sahar, Director of Aliyah Unit and Experience Israel programs, was born in Lvov, Ukraine and holds a BA in Social Work and Political Science. She worked in the IDF for 10 years. She has also served The Jewish Agency as an emissary in Uzbekistan and Ukraine. She is currently in charge of her unit's daily work, guiding the different teams and emissaries in the field, initiating projects and partnership building.
- "The challenge enables me have a real impact on society, puting a smile on the faces of youth at risk" – Muhammad Abu Al-Hija, Director, Eastern Jerusalem Youth FuturesMuhammad Abu al-Hija is the Director of Youth Futures in East Jerusalem, working with youth at-risk, and is responsible for meeting the program's educational, organizational and budget goals, guiding the Mentors, alongside welfare and educational staff. Muhammad holds a BA in Special Education, and a MA in Educational System Direction and Organization, and worked five years at the Ministry of Education.


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812 Wharf Street,
Lower Causeway Level, Victoria,
British Columbia,
From Victoria, tours range from 3-hour Zodiac and Ocean Magic Adventures to longer guided day tours with drop-off at Butchart Gardens private marine cove. Join us from May through September as we embark on an afternoon adventure across Georgia Straight on route to Vancouver. Enjoy comfort and convenience, as well as spectacular views, as we travel through the Gulf Islands behind Salt Spring Island.
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Louisville Merchandise
CollegeSports-Fans.com is a rapidly growing network of independent sports fansites covering Louisville and all Division I-A programs. Be sure to check out the College Sports Fans growing College Football & Basketball message boards and forums directory for all of the top fan sites to talk about Louisville football & basketball or to go debate with your school's rivals. Also, don't forget to come back to CollegeSports-fans.com whenever you are looking for any College Sports information or Louisville merchandise!
Dash Fans Network Home | About the DFN | Sports Writing Positions | College Sports Fan Sites | College Sports Articles
College Football Preview | College Bowl Previews | College Basketball Preview | NCAA Tournament | College World Series | Frozen Four | Wood Bat Leagues
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College apparel including clothing, hats, jerseys, gear, snuggies, tickets, Fathead sports murals and other sports merchandise has arrived!
Copyright 2005-2011, CollegeSports-fans.com and the Dash Fans Network of Independent College Sports Fan Sites.


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Have full contact with the water and bird life outside. Do not be surprised if they come asking for some food. Multi coloured walls and ceiling combined with Australian Aboriginal Art adds to the Dreamtime experience. At night the many little dimmed lights give it a luminous colourful atmosphere with reflections of the water coming inside. The extra large TV is packed with a hundred movies to see. Classical English style kitchen with high quality equipment.
The bathroom is tiled in Italian natural stone and floor heated Venetian mosaic. Extra large bath and separate shower. The entire boat is floor heated with classical mosaic wooden flooring and more Italian natural stone which gives a very comfortable climate through the whole boat. Have your breakfast or a BBQ on the big 35 m2 terrace next to the boat. Free wifi
Please note:
Check-in from 11.30
Check-out 10.30
Cancellation policy is 2 days in advance
We accept payment by cash
Minimum stay at weekends is 2 nights
- Walk through the Ten Katestraat towards our canal. (80 meters).
- After 40 meters you pass a playground on your left hand side. Continue walking.
- You can see our canal with a white bridge in the distance when in Ten Catestraat.
- In front of the white bridge turn right on the Jacob van Lennep canal and we are the third houseboat opposite house number 170.
Please call me when you arrive at the airport.
Preferably an hour before you arrive so I can be at the houseboat in time to welcome you.
Amsterdam Canal Apartments
Amsterdam, Netherlands Vacation Rentals
Two stylish and comfortable canal side apartments The "Canal View" and the "Delft Blue" apartment in the historic city centre of Amsterdam with everything of interest within walking distance.Fully equipped for two with everything you can think of!...
Starting at 150 Per Night
The Craft Apartment
Amsterdam, Netherlands Vacation Rentals
The Craft Apartment is a charming two bedroom Amsterdam apartment that can accommodate six guests, located in the Central Canal Belt in the heart of the city. Whites and earth tones dominate the space creating a welcoming home away from home....
150 Per Night
Royal House on Dam Square 18th century
Amsterdam, Netherlands Vacation Rentals
Luxurious single family house near Dam Square. 1st floor - bedroom, bathroom - Jacuzzi, shower and wc 2nd floor - bedroom, kitchen and dining room 3rd floor - bedroom, wc, terrace...
500 Per Night
Amsterdam Apartments
Amsterdam, Netherlands Vacation Rentals
Amsterdam Stay offer a selection of some amazing vacation rental apartments in all areas of the city and catering for groups of all sizes. Also budget hotels, hostels, bed and breakfasts, last minute rates and Amsterdam tours....
$125 Per Night
Amsterdam Vacation Rental Apartments
Amsterdam, Netherlands Vacation Rentals
Amsterdam Escape offer a selection of some amazing Amsterdam rentals all ideal for your next vacation in Amsterdam. Live like a real Amsterdammer during your stay wih the keys to your own Amsterdam vacation rental....
$125 Per Night
Korenbloemen studio apartment
Amsterdam, Netherlands Vacation Rentals
Canal apartment in the historic centre of Amsterdam near Nieuwmarkt and Rembrandtplein with everything of interest within a one mile radius. Fully equipped for two with everything you can think of for a comfortable and relaxed stay....
Special Discounted Rates from 110 Per Night
Simply Amsterdam Apartments
Amsterdam, Netherlands Vacation Rentals
Simply Amsterdam Apartments offers unique quality apartments and canal houses (and also a houseboat) in Amsterdam for daily, weekly or monthly rental. Stay in a historic house in the Amsterdam canal area....
$122 - 250
Contrast Deluxe
Amsterdam, Netherlands Vacation Rentals
Contrast Deluxe is a comfortable apartment capable of accommodating 14 people within way access of Amsterdam city centre....
$56 Per Night
Riverview Bed & Breakfast
Amsterdam, Netherlands Vacation Rentals
Riverview Bed & Breakfast, Amsterdam offers comfortable accommodation for up to 2 persons close to Centraal station. Ideal for exploring the sights of Amsterdam....
$285 Per Night
North Church Prinsengracht Living
Amsterdam, Netherlands Vacation Rentals
North Church Prinsengracht Living is waiting for you with a warm welcome....
$56 Per Night
Drijfpaleis Bed & Breakfast
Arnhem, Netherlands Bed & Breakfasts
Welcome to our floating palace ! A self-built romantic water villa in Tuscan style, situated on the famous river Rhine in the bustling heart of Arnhem. Please visit our website for more pictures, availability and booking....
From 75 Per Night/Room
DBs B&B in the heart of the Jordaan
Amsterdam, Netherlands Bed & Breakfasts
Located in the heart of the Jordaan, in a quiet street around the corner from famous markets, restaurants and friendly cafes. Our one-bedroom apartment is a home-away-from-home, modern, renovated interior, all comforts, and a sunny roof terrace....
Starting at 118 Per Night
charming bed & breakfast rooms centre Amsterdam
Amsterdam, Netherlands Bed & Breakfasts
marks amsterdam offers a number of convenient double rooms / bed & breakfast basis- in the centre of Amsterdam. nicely priced and very comfortable. All main tourist attractions and centre areas nearby and on walking distance....
85 Per Night
Eric B&B
Amsterdam, Netherlands Bed & Breakfasts
Bed and breakfast in your own studio apartment. Two convenient locations- Prinsengracht and Govert Flinckstraat. Both within walking distance to museums, shopping, clubs....
At Home Away From Home, guest house in city centre
Amsterdam, Netherlands Bed & Breakfasts
Offers a luxerious guestroom, where a guest feels 'home away from home'. Our guesthouse is located in the city centre! Once you've closed the door you're right in the middle of this buzzing city - feel the spirit!...
Special Discounted Rates from 75 Per Night
Amsterdam MaesB&B
Amsterdam, Netherlands Bed & Breakfasts
Cosy home ambience...Maes Bed and Breakfast. In the city center, canal area, near the Jordaan district only minutes away from the central station, museums, Dam Square, walking distance to all major sights, Cafes, and in a quiet residential area:...
Rates from 105 Per Night
Marcel's Creative Exchange - Leidseplein Amsterdam
Amsterdam, Netherlands Bed & Breakfasts
Designer and graphic artist Marcel van Woerkom rents out rooms in his lovingly restored and self-designed home in the old center of Amsterdam, Leidseplein canal ring. marcelamsterdam.nl...
Starting at 150 Per Night
Amsterdam Heren bed and breakfast
Amsterdam, Netherlands Bed & Breakfasts
'Home away from home' as most of our guests say. This Amsterdam city center B&B in canal area, near Dam square, Museums and central station is truly a quiet retreat. Yet near all tourist attractions, All the home comforts as well as many extra's....
Rates from 105 Per Night
Hotel Verdi
Amsterdam, Netherlands Hotels & Resorts
Hotel Verdi is 2-star hotel located in heart of Amsterdam. It is in close proximity to all the main tourist attractions within the city centre including the Heineken Brewery and Leidseplein, the museums ( Van Gogh Museum, Rijks Museum )....
$50 Per Night
Barangay, Award-Winning Tropical B&B in Amsterdam
Amsterdam, Netherlands Bed & Breakfasts
Multi-Award Winning Friendly Tropical B&B in the Heart of Amsterdam Center Just 3-min Walk from Central Station. The BEST LOCATION to Explore the City as Most Tourist Attractions are Literally Just Around the Corner. More at barangay.nl Thank you !...
Starting at 88 Per Night
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