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Today a few thoughts on the importance of framing your photos. We're not talking about picture frames for your photos, but the visual composition of your photographs.
Framing is the technique of drawing attention to your subject by blocking other parts of the image with something in the scene, usually in the foreground. Additional items in the foreground of your shot can also give more depth and perspective to your photos.
In the photo below, Old Prairie Homestead, the framing of the tree branches adds another layer to the photograph. They contribute some intrigue and sense of abandonment to the old farm buildings in the distance. In addition, the branches point directly at the subject in the heart of the photo.
Experiment with framing other objects into your photos to make them more visually interesting!
Greg Belfrage is an amateur photographer in Sioux Falls, SD. You can view more of his artwork at http://www.redbubble.com/people/dakotavistas or follow his photos on Facebook.


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By Taryn AsherFox 2 NewsBRIGHTON, Mich. (WJBK) -- It's been a long time coming and although it wasn't easy getting there, for those hitting the slopes, the season's first big snowfall was worth the wait."I'm very excited. I've been waiting for a really long time," said one person."I'm pretty pumped about this weather. It's a lot better than what we got last year and the year before, so I got out here soon as I could," another said.Mt. Brighton was packed Wednesday evening with skiers and snowboarders who didn't mind the whipping winds and frigid temperatures. They were eager to put their new snow toys to use.Santa brought Natalie Bloomingberg a new GoPro, a camera locked to her helmet to capture her every move."I was really excited to get it because I've wanted this for a long time because I'm a really big snowboarder," she said. "I'm really happy about the snow, too."You probably remember we barely had a winter in metro Detroit last year, so when this snow storm started heading our way, snow lovers headed straight to the store."I would say probably triple as busy," said Fidel Carino.He manages Summit Sports in Brighton. He said it is about time we saw snow like this. Business couldn't be better."For the majority of our customer, if it's not outside our kitchen window, it is so off the radar they're not even thinking about it. But one inch here and there and just seeing it fall gets them all excited, gets everybody coming in," Carino said.Like Mark Duncan and his three sons. He outfitted his kids in new gear to get them ready for the season they have been wishing for."Season was short last year. It was tough and it made it hard, but this year we started out slow, but it looks like it's getting better," said Duncan.From the ski hills to the sledding hills, even as night fell at Shepherd Park's Heritage Hill in Oak Park, nothing was going to stop the kids from enjoying some good old fashioned winter fun. They just hope Old Man Winter sticks around for awhile.
25 FOX DriveDedham, MA 02026
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Ranges in price (i.e. $98-$550) means there are multiple printings and/or sizes available. Click on an item to view a list of printings and prices.
The backstage is a fortress, each inner door demanding a further credential of access. Also known as silkies or satins, backstage passes were the first created insignia of such privilege. Our collection of passes carry the credentials to get one from the fan-club after-show all the way to center-stage.
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ōDo you want to see a movie tonight?ö asked my husband.
It was a perfectly reasonable question. It was a Saturday afternoon. We had no plans. But having been married to this guy for 20 years, I knew this question wasnÆt as innocent as it seemed. There was a hidden meaning. It was actually code for, ōDo you want to see that new action movie with lots of special effects, a huge body count and bad guys with fake foreign accents?ö
ōWhat did you have in mind?ö I asked innocently.
ōThe new James Bond movie,ö he responded.
I snorted to myself. My husband and I have a lot of similar tastes, which is probably one of the reasons we have stayed married so long. But when it comes to movies, we are clearly divided along gender lines. He likes sports-themed films and big action movies, and I like chick flicks. This is not to say that I donÆt like an occasional football film or action movie, too. I was actually sitting in an action movie when I went into labor with my son. Truthfully, itÆs much easier to have contractions when things are blowing up on screen than when two people are discussing their relationship issues. But I like to mix it up and every once in a while see a good rom-com or foreign film or something that does not include zombies, intergalactic battles, Tom Cruise rappelling off a building, or men in tight spandex superhero costumes. Actually scratch that last one. IÆm OK with that.
On the flip side, my husband is not much of a fan of chick flicks. Although he admits that seeing one is a good opportunity for him to catch up on his sleep, most of the time, I have to drag him kicking and screaming with promises of large quantities of Twizzlers to get him to go. Then he will sit in his seat, chewing Twizzlers and looking wistfully at the wall separating the multiplex where sounds of extreme violence and things exploding come from the theater next door.
This being the case, when he asked me to see another action film, he knew that it was going to be a tough sell, so he decided to take a different tack .
ōÆSkyfallÆ is an action movie, but at itÆs heart itÆs really a love story,ö he said.
ōHow do you figure?ö I wondered.
ōThe movie is about the unresolved relationship between Bond and Miss Moneypenny,ö he explained. ōItÆs really a romance with some action thrown in.ö
Having seen a dozen or so other James Bond movies, I was fairly certain this description was about as fitting as calling ōThe Godfatherö a comedy. Although I was impressed that he had obviously put a great deal of effort into this argument, I still wasnÆt biting.
Page 2 of 2 - ōActually, I had something else in mind,ö I replied. ōThereÆs this new baseball movie I think youÆd really like that IÆd be willing to see.ö
ōBaseball? Cool! WhatÆs it called?ö
ōPitch Perfect.ö
TracyÆs new book, ōLost in Suburbia: A Momoir. How I Got Pregnant, Lost Myself, and Got My Cool Back in the New Jersey Suburbsö is now available for PRE-ORDER! To reserve your copy, got to Amazon or any online bookseller.


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Made in Sweden, the FireKnife is a handy tool which you can use to gut and clean a fish, split kindling, and light a campfire.
Swedish FireKnife has received outstanding reviews with outdoors experts. It is tough enough to split wood, yet sharp enough to shave with. The sheath holds the knife securely, and has a built-in FireSteel for lighting fires. Simply twist and pull to release the fire starter.
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- A tree planted for every order with the Trees for the Future Foundation
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This excellent site is put together by the Discovery Channel and is designed to help you figure out how to design and conduct experiments and present your results. It has tips on creating display boards for science fairs, how to deliver a good oral presentation, things that judges might look for, and more.
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Parliament of Australia
House is live
House of Representatives
Senate is live
Parliament of Australia site sections
Current section pages
Page tools
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Aboriginal legal services Compliance audits into aboriginal legal services Special audit of the Victorian Aboriginal Legal Service (VALS), June 1996
Aborigines Aboriginal art A discussion paper and pertinent questions regarding the economics of the Aboriginal art industry of the Northern Territory, September 2000
Aborigines Aboriginal Mining Enterprise Task Force meeting, Nauiyu, 11 July 2000 Education anad employment: The future for Aboriginal people-paper prepared by Miriam-Rose Baumann AM
Aborigines National Sorry Day Letter to the President from the Minister for Aboriginal and Torres Strait Islander Affairs, dated 23 June 1999
Aborigines Northern Territory legislation Letter from the Chief Minister of the Northern Territory, dated 25 July 2001
Aborigines Reconciliation Committees Responses from the Premier of Victoria [Mr Bracks], dated 6 December 2000
Aborigines Traditional medicine Copy of paper by Dr Dayalan Devanesen, Traditional Aboriginal medicine practice in the Northern Territory-Presented at International Symposium on Traditional Medicaine, Awaji Island, Japan, 11-13 September 2000
Access to Justice (Civil Litigation Reforms) Amendment Bill 2009 Explanatory memorandum Addendum
Access to Justice (Civil Litigation Reforms) Amendment Bill 2009 Supplementary explanatory memorandum
Access to Justice (Civil Litigation Reforms) Amendment Bill 2009 Supplementary explanatory memorandum Correction
Documents used in the chambers to facilitate the conduct of business. The documents include the agenda for each sitting day (Senate Order of Business and House of Representatives Daily Program), the business currently before each chamber (the Notice Papers) and the minutes of meeting for each sitting day (Journals of the Senate and Votes and Proceedings for the House of Representatives).
Parliamentary sitting calendar
Go to the full calendar of events
Browse all Senators and Members


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Feedback on provisional specs for OpenMAX AL DTV
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Allows you to choose the data by which the thread list will be sorted.
Order threads in...
Note: when sorting by date, 'descending order' will show the newest results first.
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Seen in the Bike Hugger Urban group on Flickr.
Uploaded by gregraisman | more from the Bike Hugger Photostream.
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ProSport 20+ Generation 2 Onboard Battery Charger, 20amp, 3Bank - ProMariner
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Charge profiles can be programmed and reprogrammed with simplicity. ProSport delivers increased power and performance for faster charge times with its rugged 100% waterproof/shockproof design utilizing Advanced Electronic Technology in a heavy duty compact and lightweight case. The ProSport series still features Distrubuted-On-Demand™ charging--so 100% of the output is always used, distributing total available charging amps to one bank or a combination of all banks as required. Fully automatic, multistage charging with a safe maintenance mode for long- or short-term storage. Dynamic thermal output control gives you the appropriate charging amps while maintaining the proper temperature. Built-in ignition, reverse polarity, overheat, and short-circuit protection. Fully prewired. Manufacturer's two-year warranty.Recreational Sport Fishing & Boating On-Board Marine Battery Chargers
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Flag Blue Perfection Top Side Boat Paint, Quart - Interlux
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"You want to get Detroit straight get Michigan straight. Get Michigan straight and stop having people held up in those Secretary of State [offices] like cattle," said Christal Bonner.
She showed us the bruises on her wrists from being handcuffed. Bonner was arrested for disorderly conduct at the Secretary of State branch in St. Clair Shores on Tuesday shortly before 5:00 p.m. in a packed office where she had been waiting for more than an hour and a half when she demanded to see a supervisor.
"I said, 'Are you the supervisor?' And she said, 'Are you the one that's been yelling you want to see a supervisor?' She said, 'I'm going to call the police on you and have you arrested for disorderly conduct.' I said, 'Madam, I didn't come down here to get threatened by the police. I came here to take care of some business. Can't you see this place is out of control?' she explained.
Bonner said she went back to her seat in the standing room only crowd and called a complaint number she had been given, then two St. Clair Shores police officers arrived.
"I looked around and I said, 'Did anyone call H-19.' And that's when the police officer said, 'That's it.' He grabbed my arms, yanked [them] behind my back and crushed some handcuffs on me. And then he proceeded to jerk me around," she said.
St. Clair Shores police said they will look into Bonner's complaints, but that she refused to listen to the officers and calm down.
A spokesperson with the Secretary of State told us the manager called police after Bonner began swearing and yelling at staff, being abusive and disrupting the operation of the entire office. That spokesperson also admitted the office was extremely crowded that day.
"Is this how they're handling their customer service? If it gets too crowded let's just call the police and have you hauled out of here," said Bonner. "I've never been arrested in my life. I'm a law abiding citizen. I have six children. I'm a teacher, okay. I'm a taxpayer."
Bonner is not the only one complaining. So many Secretary of State branches have closed it seems the ones that are left are just way too crowded.
In the last ten years, branch offices have been consolidated. They are down from around 170 locations to 130, and staff has been cut by 25 percent.
"It's terrible because I live in Algonac and the one that was up in Marine City was wonderful. If you waited two minutes that was it," said Jan Cusmano. "It closed."
"We're like cattle. They can't get away with this. We have to have good customer service in the State of Michigan," Bonner said.
KDFW FOX 4400 N. Griffin StreetDallas, Texas 75202
Main Station Directory:(214) 720-4444News Fax:(214) 720-3263 or (214) 720-3333


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Chava Ceramic Mug
Item# 011024737
Product Info
An elegant yet durable 10 oz. porcelain mug.
Product Details
This beautifully handcrafted 10 oz. mug has been known to hypnotize people with its elegant lines and enduring qualities. Don't be surprised if you find yourself staring at it and then suddenly realizing your tea might be getting cold. No worries. This pure porcelain mug will keep you flavorful Tazo tea hot while giving you a stunning way to enjoy it in style. Dishwasher and microwave safe.
Durable and elegant. Complements the Chava collection
Technical Details


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PhD University of Washington
Dr. Thomas L. Porter brings over thirty years of professional accounting experience into the Hult classroom. After receiving his Ph.D. from the University of Washington, he taught at Boston College then worked at the Financial Accounting Standards Board. Most recently, he was vice president at NERA Economic Consulting where he provided expert witness services on accounting-related matters in commercial litigation.
(Full Time)


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Five Years to FreedomRandom House Publishing Group 2011; US$ 7.99
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The Broken KingdomsLittle, Brown Book Group 2010; Not Available
In the city of Shadow, beneath the World Tree, alleyways shimmer with magic and godlings live hidden among mortalkind. Oree Shoth, a blind artist, takes in a homeless man who glows like a living sun to her strange sight. However, this act of kindness is to engulf Oree in a nightmarish conspiracy. Someone, somehow, is murdering godlings, leaving their... more...
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For two thousand years the Arameri family has ruled the world by enslaving the very gods that created mortalkind. Now the gods are free, and the Arameri's ruthless grip is slipping. Yet they are all that stands between peace and world-spanning, unending war. Shahar, last scion of the family, must choose her loyalties. She yearns to trust Sieh, the... more...
The Killing MoonLittle, Brown Book Group 2012; Not Available
In the ancient city-state of Gujaareh, peace is the only law. Upon its rooftops and amongst the shadows of its cobbled streets wait the Gatherers - the keepers of this peace. Priests of the dream-goddess, their duty is to harvest the magic of the sleeping mind and use it to heal, soothe... and kill those judged corrupt. But when a conspiracy blooms... more...
The Shadowed SunLittle, Brown Book Group 2012; Not Available
Book two in a gripping and beautifully-crafted fantasy duology from the critically acclaimed author of THE HUNDRED THOUSAND KINGDOMS. more...
Tallinn Manual on the International Law Applicable to Cyber WarfareCambridge University Press 2013; US$ 47.00
The result of a three-year project, this manual addresses the entire spectrum of international legal issues raised by cyber warfare. more...
Motion DeblurringCambridge University Press 2014; US$ 96.00
Comprehensive guide to the restoration of images degraded by motion blur, encompassing algorithms and architectures, with novel computational photography methods. more...
Selected DialoguesOxford University Press 2006; US$ 8.99
you'll find another man to harvest, Glycerion: let this one go'The Greek satirist Lucian was a brilliantly entertaining writer who invented the comic dialogue as a vehicle for satiric comment. His influence was immense, not only in the Greek world, but on later European writers such as Rabelais and Swift. His dialogues puncture the pretensions... more...
Methods in Molecular BiophysicsCambridge University Press 2007; US$ 103.00
Advanced textbook describing the key physical methods used in molecular biophysics. more...
The Epilepsy Prescriber's Guide to Antiepileptic DrugsCambridge University Press 2013; US$ 56.00
Helps prescribers to easily and rapidly answer questions that may arise when initiating and monitoring an antiepileptic drug. more...


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MODERN FAMILY - "The Big Game" - With a big football game coming up and a record to break, Coach Cam is intensely focused and showing no mercy even when the opposing team is playing with an unexpected disadvantage. Elsewhere, Claire is determined to prove to the staff that she is more than just the boss's daughter, and Phil tries to teach his kids a lesson about optimism, but the universe just isn't cooperating, on "Modern Family," WEDNESDAY, DECEMBER 4 (9:00-9:31 p.m., ET), on the ABC Television Network. (ABC/Peter "Hopper" Stone) RICO RODRIGUEZ, ZACHARY CONNEEN, ERIC STONESTREET
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Duo Eyeshadow Oáhu no 903 from Viva La Diva is a duo eyeshadow with two colourful shades of turquoise and green. The shadows with its intense pigment is for those who dare to have a bit of colour. Shadows do not need to be applied to the entire eyelid. For those who still want great colours but want subtler results can add shadow to a smaller brush and just apply to the lash line.
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More about the brandViva la Diva was founded in Sweden in 2000 by Valtea Cosmetics and immediately became one of the most successful brands on the Swedish market within the mass-market segment. Viva la Diva is one of the major brands on the market in the segment of nail polish, lipstick and eye shadow. Viva la Diva offers high quality makeup products often in vibrant colours, along with a pricing structure that makes the brand extremely competitive and appreciated by both ordinary consumers and professional makeup artists. Products are not tested on animals. The brand appeals often to women who dare to highlight their personalities a little more and go their own ways. The name Viva la Diva calls for an independent creative thinking in both fashion and makeup choices, and of course, in everyday life. Read more
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Study Offers Promise for Detecting Pancreatic Cancer
Using novel protein microarray technology, researchers have identified a panel of 10 protein biomarkers found in blood samples that proved highly accurate at detecting the existence of pancreatic cancer and identifying truly negative samples.
Several biomarker experts called the findings preliminary but promising. But there is still much work to be done before a commercially available test could reach the clinic, acknowledged the study's leader, Dr. Anna E. Lokshin of the University of Pittsburgh School of Medicine. Read more
What's Next for Cancer Stem Cells?
The concept of cancer stem cells has generated great excitement in the research community. These cells - the hallmark of which is resistance to therapy and the ability to self-renew and produce a differentiated population of daughter cells - have been identified in many solid and hematopoietic cancer types.
With the intention of supporting research in this new field, on November 1, we held the first NCI Stem Cell Mini-Retreat, where NCI and NIH researchers and extramural investigators gathered to learn from each other about the latest advances in stem cell research and to identify opportunities for collaboration that could significantly advance the field, expand translational opportunities, and leverage resources. Read more
Study Offers Promise for Detecting Pancreatic Cancer
Using novel protein microarray technology, researchers have identified a panel of 10 protein biomarkers found in blood samples that proved highly accurate at detecting the existence of pancreatic cancer and identifying truly negative samples.
Several biomarker experts called the findings preliminary but promising. But there is still much work to be done before a commercially available test could reach the clinic, acknowledged the study's leader, Dr. Anna E. Lokshin of the University of Pittsburgh School of Medicine.
"We are still looking for more potential biomarkers in order to increase the sensitivity of this screening method to 100 percent," she said. "So far, these preliminary results are very encouraging, but we need to reach 100 percent accuracy before this test can be widely used."
Dr. Lokshin presented the study results on Monday in Boston at the American Association for Cancer Research's (AACR) Frontiers in Cancer Prevention Research meeting. The study was conducted in conjunction with researchers from Harvard and Northwestern Universities.
The research team began with a panel of 44 biomarkers, which, as Dr. Lokshin explained, "represent the dialogue between the tumor and the body" - that is, proteins that are secreted by tumor cells, the vasculature that feeds the tumor, immune system cells, and cells in the tumor microenvironment generated as a result of a tumor's presence.
They then used a protein array system to analyze blood samples from 100 patients with both resectable and nonresectable pancreatic cancer, including some patients with early-stage disease, and a control group of 400 healthy participants. They found marked differences in the expression of many of these proteins in the patient samples compared with those from controls.
Using "our own, quite powerful algorithm," Dr. Lokshin said, they discovered a 10-biomarker panel that correctly identified 97 percent of patient samples. In addition, the panel's sensitivity and specificity - its ability to correctly identify a malignancy and rule out cancer - was 95 percent and 98 percent, respectively.
"Since the completion of this study, we have been able to reproduce these results in a blinded validation set, with strong diagnostic power, and 87 percent sensitivity and 98 percent specificity," Dr. Lokshin said.
Dr. Sudhir Srivastava, head of NCI's Early Detection Research Network (EDRN), which funded the study, lauded the team's work, but cautioned against reading too much into the results.
"We must narrow down the panel so it becomes more organ specific," he explained. While some of the biomarkers used in the study are expressed in pancreatic cancer, he noted, they are also overly expressed in other cancers, so there is a significant risk of "cross reactivity."
The results presented in Boston did show that the 10-biomarker panel specifically recognized patients with pancreatic cancer, but not patients with other cancers, including lung, esophageal, head and neck, ovarian, breast, endometrial, and melanoma.
The diagnostic platform used to test the samples also will need to be standardized, Dr. Srivastava added, and the refined biomarker panel tested in different patient cohorts to ensure that the results are reproducible from one site to the next.
Perhaps most important, he said, "it has to be tested on prospectively collected samples, so we can determine what kind of benefit you get in terms of lead time." In other words, can the test detect the disease early enough in its course that treatment will actually improve survival? The statistical algorithms used to analyze the data must also be validated, he added.
"The validation steps will be crucial to determine whether these initial exciting results hold up," said Dr. Teri Brentnall, a researcher at the University of Washington Medical Center, who also is doing work in this area.
By Carmen Phillips, with additional reporting by Heather Maisey
What's Next for Cancer Stem Cells?
The concept of cancer stem cells has generated great excitement in the research community. These cells - the hallmark of which is resistance to therapy and the ability to self-renew and produce a differentiated population of daughter cells - have been identified in many solid and hematopoietic cancer types.
With the intention of supporting research in this new field, on November 1, we held the first NCI Stem Cell Mini-Retreat, where NCI and NIH researchers and extramural investigators gathered to learn from each other about the latest advances in stem cell research and to identify opportunities for collaboration that could significantly advance the field, expand translational opportunities, and leverage resources.
The implications of these cells for cancer treatment are enormous. Although relatively rare, with only about 1 out of 1,000 to 10,000 cells in any given tumor, their resistance to standard therapies and their proliferative potential make them a likely cause of many recurrences after seemingly curative treatment. Their plasticity and ability to survive a hostile environment through quiescence - the state of being dormant - are also thought to contribute to their metastatic potential.
As I mentioned in a previous column, new insights into the role of these cells in tumorigenesis and metastasis make this an excellent time to accelerate study in this field. One of the primary goals of the November 1 retreat was to identify the immediate impediments to rapid progress in cancer stem cell research.
In the area of basic research, participants highlighted the need to accurately identify these rare cells. Much of this identification will come from elucidating specific cell markers and aberrantly expressed signaling pathways, both of which also have implications for targeted therapy.
Speakers also discussed the current challenges in isolating and growing these cells, which are difficult to maintain in culture, and the pressing need for appropriate models to test therapies both in vitro and in vivo.
In the area of treatment, the crux of the discussion revolved around one major question: By identifying and blocking specific cell-signaling pathways, is it possible to nullify the "stemness" of these cells, leaving them vulnerable to treatment?
This question highlights other challenges. For example, cancer stem cells often cycle into a quiescent state, requiring identification of a stimulus to activate them before treatment. The design of clinical trials in this field will need to identify new methods to evaluate the success of anticancer stem cell therapies. Clearly we have a lot of work ahead of us. The final question posed at the retreat asked what NCI would do next to promote the necessary research in this field.
We have been inspired by the success of the Trans-NIH Angiogenesis Research Program (TARP) in promoting collaborations between investigators from many different disciplines, and hope to soon launch a similar trans-NIH stem cell biology and embryogenesis initiative, to facilitate the exchange of knowledge and technology both intramurally and extramurally.
NCI is now beginning the process of planning a multi-day symposium, hopefully on an annual schedule, to launch this new initiative. This type of symposium has been very helpful for TARP, and will let investigators identify opportunities for funding, resource sharing, and potential for collaborations.
Though the field of cancer stem cells is new, it holds great promise, and NCI is committed to supporting new research in this area.
Dr. John E. Niederhuber
Brain Radiation Linked to Strokes in Childhood Cancer Survivors
Increased risk of stroke must now be added to the list of adverse late effects that are possible in survivors of childhood cancers who received high-dose cranial radiotherapy (CRT), according to new findings from the Childhood Cancer Survivors Study (CCSS) published online November 6 in the Journal of Clinical Oncology.
Lead author Dr. Daniel C. Bowers of the University of Texas Southwestern Medical Center at Dallas and colleagues used the longitudinal CCSS to assess risk of individuals treated as children for leukemia or brain tumors, compared with a control group of 3,846 siblings who did not have cancer as children.
Although strokes occurred in a small percentage of children surviving more than 5 years after treatment, the effect of CRT on this risk was significant. When radiation was directed at particular areas of the brain, the risk of stroke increased as the radiation dose increased. Chemotherapy had little effect on stroke risk in leukemia patients but more than doubled the risk in brain tumor patients who also had CRT.
The study found that childhood leukemia patients who received CRT were 6.4 times more likely to have a stroke than those in the control group, while brain tumor patients treated with CRT had a significantly larger risk of 29, compared with controls.
The authors conclude that this study "identifies a significantly increased incidence of stroke among long-term survivors of childhood leukemia and brain tumors. This study also identifies the use of CRT, in a dose-dependent fashion, as contributing to the increased risk of stroke, and justifies efforts to continue to reduce radiation doses among both leukemia and brain tumor treatment regimens whenever practical."
Public Awareness of HPV Link to Cervical Cancer Is Low
In 2005, before the approval of the human papillomavirus (HPV) vaccine, awareness among American women about HPV and its link to cervical cancer was low, according to an NCI study presented this week at the AACR Frontiers in Cancer Prevention meeting.
NCI scientists analyzed data collected from more than 3,000 women aged 18 to 75 who responded to the 2005 Health Information National Trends Survey (HINTS). The researchers found that only 40 percent had ever heard about HPV and less than half of those were aware of the virus' connection to cervical cancer. Awareness of HPV and cervical cancer was especially low among women who were older, less educated, or less exposed to health information.
Dr. Jasmin A. Tiro, an NCI Cancer Prevention Fellow who led the study, commented, "Our data also suggest that women learn about HPV after experiencing an abnormal Pap or positive HPV test. Clear, consistent information about HPV transmission, prevention, detection, and the link to cervical cancer needs to be provided before a woman becomes infected."
Media coverage and pharmaceutical marketing efforts for the HPV diagnostic test and the HPV vaccine "will likely increase awareness," Dr. Tiro predicted. "NCI is conducting studies to track the diffusion of knowledge to make sure that all women have accurate knowledge about HPV and how to prevent and detect cervical cancer early." Understanding HPV infection and its relationship to cervical cancer is needed to make appropriate, evidence-based health care choices among existing strategies, including the Pap test, HPV DNA test, and HPV vaccine, the researchers concluded.
New Therapeutic Targets Identified in Leukemia
A translocation between chromosomes 9 and 22, known as the Philadelphia chromosome, causes expression of a chimeric and constantly expressed form of the protein BCR-ABL. Aberrant expression of BCR-ABL in bone marrow cells leads to chronic myeloid leukemia (CML) and B cell acute lymphoblastic leukemia (B-ALL). The drug imatinib (Gleevec) inhibits BCR-ABL, and has become the standard of care for chronic-phase, Philadelphia chromosome-positive leukemias. However, imatinib cannot eliminate all leukemia cells expressing BCR-ABL, and many patients eventually develop resistance to the drug.
A new study published online November 7 in the Proceedings of the National Academy of Sciences shows that while imatinib inhibits BCR-ABL, it does not affect downstream proteins in the BCR-ABL signaling pathway called SRC kinases. Using mouse models of CML and B-ALL, investigators from the Jackson Laboratory in Bar Harbor, Maine, determined that these SRC proteins may play an important part in the malignant transformation of cells in the bone marrow, contribute to disease progression, and allow leukemia cells to survive imatinib treatment until resistance develops. Treatment of mice with the drug dasatinib inhibited both BCR-ABL and SRC expression; this dual inhibition suppressed B-ALL and significantly prolonged survival of mice with CML. However, dasatinib was unable to completely kill residual leukemia cells.
The authors next identified sets of leukemia cells with stem-cell-like properties in mice with B-ALL and CML. These cells were not killed by either imatinib or dasatinib, and were capable of inducing leukemia when transplanted to healthy animals. While dasatinib may be effective in producing long-term remission, explained the authors, "identification of unknown pathways in CML stem cells will be critical for developing curative therapies for the disease."
Experimental Melanoma Drug Shows Early Promise
A drug containing parts of the diphtheria toxin may have benefited a small number of patients in the advanced stages of melanoma skin cancer. Five out of seven patients with stage IV disease experienced significant regression or stabilization of their tumors and the spread of cancer while taking the drug, according to preliminary findings from a phase II clinical trial.
The trial is testing the effectiveness of the experimental drug denileukin diftitox, also known as DAB(389)IL2 or ONTAK, for treating the deadly disease. The median life expectancy for patients with stage IV melanoma is normally about 8 months. All of the patients were still alive after 12 months. The two patients in whom the melanoma progressed were on a lower dose of the drug than the others.
The drug is thought to prompt the immune system to attack tumors by depleting a subset of regulatory T cells thought to directly suppress the activation of the antitumor T cells. Research in mice has suggested that if the regulatory T cells are depleted by targeting them with denileukin diftitox, then T cells in the immune system known as CD8+ T lymphocytes would be able to attack and kill melanoma cells.
Lead investigator Dr. Jason Chesney of the University of Louisville's Brown Cancer Center presented the preliminary findings November 9 at the Symposium on Molecular Targets and Cancer Therapeutics in Prague.
Oncolytic Virus Kills Malignant Glioma Cells
Canadian researchers have shown that an "oncolytic virus" they have developed is effective at infecting and killing malignant glioma cells, and targets the main tumor when administered intravenously. Oncolytic viruses are viruses that are engineered to infect and kill only cancer cells.
Dr. Peter Forsyth and colleagues of the University of Calgary tested the effects of recombinant vesicular stomatitis virus (VSVΔM51), a mutant strain of vesicular stomatitis virus, on 14 human glioma cell lines, a glioma mouse model, and human tumor specimens. They also compared the effects of VSVΔM51 with reovirus serotype 3, another oncolytic virus under investigation for the treatment of brain tumors, on human glioma cell lines.
The study, published in the November 1 Journal of the National Cancer Institute, found that all 14 glioma cell lines were susceptible to infection and killing by VSVΔM51, while only 12 of the lines were susceptible to infection and killing by reovirus serotype 3. Neither VSVΔM51 nor reovirus serotype 3 had an effect on the normal cell lines. Mice that received live VSVΔM51 intravenously had improved survival compared with mice that received dead VSVΔM51 intravenously. The virus also infected both multifocal glioma cells and invasive glioma cells.
The ideal oncolytic virus for cancer "should have effective delivery into multiple sites within the tumor, evade innate and acquired immune responses, produce rapid viral replication, spread within the tumor, and infect multifocal tumors," the authors wrote. "This is precisely what we found using the attenuated live virus we constructed (VSVΔM51)."
Following are newly released NCI research funding opportunities:
Understanding and Promoting Health Literacy
This is a renewal of PAR-06-132 and will use the R03 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3551. Inquiries: Dr. Sabra F. Woolley - firstname.lastname@example.com
Image-Guided Cancer Interventions
This is a renewal of PA-06-031 and will use the R41 and R42 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3553. Inquiries: Dr. Keyvan Farahani - email@example.com; Dr. Laurence P. Clark - email@example.com
Image-Guided Cancer Interventions
This is a renewal of PA-06-032 and will use the R43 and R44 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3554. Inquiries: Dr. Keyvan Farahani - email@example.com; Dr. Laurence P. Clarke - email@example.com
Targeting Cancer and Monitoring the Heart
A surprise no one wants during the final stage of a clinical trial is to learn that a cancer drug can cause heart failure. But that is exactly what happened with the breast cancer drug trastuzumab (Herceptin).
The preclinical work and early phase I trials did not turn up any signs of cardiac side effects. Yet, as so often happens, a rare toxicity - in this case congestive heart failure - was discovered when more people took the drug.
Heart failure was first reported in the late 1990s during the definitive trials involving women with metastatic breast cancer, and it occurred most often in women also taking doxorubicin. All subsequent trials have included careful cardiac monitoring.
Today, the risks are measured against the enormous potential benefits. Trastuzumab has helped many women with HER2-positive breast cancer survive their disease and, when used in the adjuvant setting, it reduces the risk of recurrence by half.
"We have to be very cautious in administering the drug, and we have to be very cautious in not administering it, because the benefits for some patients are astonishing," says Dr. Daniel Hayes, director of the Breast Oncology Program at the University of Michigan Comprehensive Cancer Center.
This assessment may apply to other "targeted" cancer therapies as well. Drugs such as bevacizumab (Avastin), sunitinib (Sutent), imatinib (Gleevec), and dasatinib (Sprycel) are effective but may slightly increase the risk of heart failure, and this has raised concerns.
In articles and at scientific meetings, oncologists and cardiologists have called for rigorous evaluations of cardiac side effects early in drug development, and for careful monitoring of cardiac health throughout clinical testing.
"We need to be vigilant for toxicities, and any emerging toxicities need to be balanced with the benefit that's seen for these drugs," says Dr. Walter Stadler of the University of Chicago, who treats prostate and kidney cancers.
The emergence of targeted drugs, he suggests, may force clinicians to relearn treatments for a new set of toxicities, such as hypertension, that previously had not been relevant.
What has changed, of course, are the targets. Unlike traditional chemotherapy drugs, these therapies mainly inhibit proteins involved in angiogenesis - the growth of blood vessels - and proteins that transmit signals within cells called tyrosine kinases.
Virtually all of the proteins are present in both normal cells and cancer cells.
The genetic similarity between normal cells and cancer cells all but guarantees that interventions will have some effects in normal tissues, according to Dr. Gabriel Hortobagyi, who chairs the Department of Breast Medical Oncology at the University of Texas M.D. Anderson Cancer Center.
"None of these targeted agents has a single and absolutely specific activity, and that clarification needs to go out to the public and to our colleagues in medicine," says Dr. Hortobagyi, who is also president of the American Society of Clinical Oncology (ASCO).
"We have been talking about these drugs as though they have no toxicities at all," he continues. "In this exciting time of targeted therapies, we need to be clear that we still don't have free lunches."
People in the field are aware of the problem, and most clinical trials are looking for signs of heart failure, notes Dr. Sandra M. Swain, an investigator in NCI's Medical Oncology Branch who is planning breast cancer clinical trials.
Candidates for the drugs are routinely screened for health conditions that increase the risk of cardiac toxicities, such as diabetes and high blood pressure.
Most cases of heart failure caused by trastuzumab are treatable, but the long-term consequences for patients who experience heart failure are not known. Nor is it known how long patients treated for heart failure will need to take heart medications.
Another common question is whether all tyrosine kinase inhibitors have cardiac toxicities. No one knows the answer, but some experts say that each drug has different targets and will need to be evaluated individually.
"We have to do the studies to understand targeted drugs better so we can treat patients in a safe way," says Dr. Arthur Feldman, a cardiologist and chair of the Department of Medicine at Jefferson Medical College. "Right now we don't have the data."
To get answers, oncologists need to reach out "pretty aggressively" to cardiologists and involve them early in clinical trials as a way to ensure that the right kinds of cardiac evaluations are done in these patients, he says.
In this spirit of cooperation, cardiologists and oncologists recently met in Houston to discuss ways to eliminate cardiovascular disease as a barrier to treatment for cancer. Chemotherapy was the focus, but targeted drugs were discussed.
"We think the future looks really bright for these drugs, but the way we deliver them is going to require teamwork," says co-organizer Dr. Jean-Bernard Durand of the Cardiomyopathy Service at M.D. Anderson.
"Good medical management with drugs already approved by the FDA for heart failure may solve a number of these issues," he adds.
The meeting was the first initiative of CONQUER (Cardiology Oncology International Quest to Educate and Research Heart Failure). The presidents of ASCO and the Heart Failure Society of America both participated.
"The issues of efficacy and toxicity go hand in hand," says Dr. Hortobagyi. "The best we can do is to assume that toxicities are going to occur and take all of the proper precautions without slowing down progress."
By Edward R. Winstead
Treatment Based on Colorectal Tumor Protein Level
Name of the Trial
Principal Investigators
Why This Trial Is Important
The drug fluorouracil (5-FU) is often used to treat colorectal cancer; however, previous clinical studies suggest that tumors with a high level of the protein thymidylate synthase (TS) are more likely to be resistant to 5-FU treatment.
In this trial, researchers will measure the level of TS in the tumors of patients with metastatic colorectal cancer. Patients whose tumors show a low level of TS will be treated with combination chemotherapy consisting of 5-FU, leucovorin calcium, and oxaliplatin (the so-called "FOLFOX" regimen) plus the monoclonal antibody bevacizumab. Patients whose tumors show a high level of TS will be treated either with the same drug combination plus bevacizumab or with an investigational combination of the drugs oxaliplatin and irinotecan plus bevacizumab. Researchers want to determine whether replacing 5-FU and leucovorin calcium with irinotecan will lead to better response rates and survival in these patients.
"As the array of treatments for metastatic colorectal cancer expands, it's important to match specific treatments with those patients who are most likely to benefit from them," said Dr. Meropol. "This is the first national study for patients with metastatic colorectal cancer to prospectively assign treatment based on the molecular characteristics of the tumor."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
The President's Cancer Panel is holding a series of meetings on "Promoting Healthy Lifestyles to Reduce the Risk of Cancer." The second meeting in the series was held October 23 in Lexington, Ky. Panelists presented testimony on the effect of tobacco and environmental tobacco smoke on cancer risk and on effective programs and policies to combat the problem throughout the United States.
The next meeting will take place on December 5 in Portland, Ore., where the Panel will hear testimony on how obesity, physical activity, and nutrition affect cancer risk.
Meetings of the President's Cancer Panel are free, open to the public, and require no registration. More information is available online about the Panel and these meetings at http://pcp.cancer.gov.
Great American Smokeout Promotes Smoking Cessation
An estimated 46 million adults in the United States currently smoke, and about half will die prematurely from smoking. Cigarette smoking causes 87 percent of lung cancer deaths. Information on the Smokeout is available at http://www.cancer.org/docroot/PED/ped_10_4.asp. Information about quitting smoking is available at www.smokefree.gov.
NCI Scientists Recognized for HPV Vaccine Development
Pancreatic Cancer Awareness in November
Innovative e-Health Products Enhance Communication
"When the program started, the products were primarily videos," says Connie Dresser, program director. "Products now include interactive CD-ROMs, Web-based educational and training resources, communication systems, wireless technology products, and radio programs targeted to both consumers and health care professionals.
"The products cover a wide range of topics, with tobacco prevention and cessation products currently taking up a third of the portfolio," Ms. Dresser continues. "All of the products are cancer related, but grantees are encouraged to develop models that can be used for other chronic diseases."
Housed in the Health Communication and Informatics Research Branch in the Division of Cancer Control and Population Sciences (DCCPS), the program has produced about 84 e-health products since 1992, and Ms. Dresser estimates that 60 percent of them have been brought to market. Many products have received awards, including World Wide Web Health Awards, Eddie Awards for Educational Technology, and Technology Games Awards. A video for men diagnosed with prostate cancer aired on PBS-TV and was nominated for an Emmy award.
DCCPS develops categories for SBIR/STTR grant applications annually to address gaps in e-health research. In 2006, the program focused on collaborations with public health professionals to promote positive dietary changes, programs to enhance people's awareness of their responsibility for preventing or managing chronic diseases, systems for capturing family health histories, and wireless technologies for collecting and integrating patient informatics.
"This SBIR program includes requirements designed to offer the best chance for a product's success, including rigorous review and evaluation processes," says Ms. Dresser. "While follow-up of products isn't a requirement, we feel it's important to monitor commercial success after the grant is ended to let grantees and contractors know that NCI expects the companies to succeed."


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BURNCO is proud to announce the acquisition of Gateway Concrete's assets in Texas. We are committed to bringing our values and sense of community to this growing market.
Business Divisions
Career Opportunities
We have a wide range of current job openings throughout BURNCO. Find the perfect fit for your BURNCO career here. View available positions
We produce and sell sand and gravel from properties in Alberta & British Columbia.
Ready Mix
25 concrete plants throughout Western Canada provide ready mix services.
We produce and supply a full range of hot and cold mix asphalt to contractors.
Landscape Centres
We provide retail customers with a "One Stop Shop" for all landscape supplies.


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Female Acupuncture Model - Small
Both Chinese and English coded points illustration.
A wooden base for display mounting and a point location booklet.
Height: 50cm.
Weight (including packaging): 1400g
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For the third year in a row, the Phillies and ARAMARK are partnering with the Pennsylvania Horticultural Society on its effort to Plant One Million.
Plant One Million is an ambitious multi-state tree-planting campaign, encompassing 13 counties in southeastern Pennsylvania and parts of New Jersey and Delaware. For each home run hit by a Phillies player this season, a tree will be planted as part of the program. We will once again plant the trees in the fall.
Watch Video | Utley Video
The goal is to increase the "tree canopy cover" - the area of land shaded by trees - in the tri-state area to 30 percent, the greatest coverage in more than a century, by planting one million trees by 2020. Learn more at plantonemillion.org
Trees can increase property values and retail sales, reduce energy costs, flooding, and crime rates, improve air and water quality, and enhance the overall health and quality of life for local residents.


text: The founders of Rhino Shield started as home improvement contractors in the Florida Panhandle, which is known for its extreme heat and humidity, frosty cold, torrential rain, and of course, hurricanes. Over the years, they sold and applied many different paints and coatings, including national brand paints, and even proprietary coatings with long term warranties. More>>


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Louisiana has suffered a long, hot, humid summer. Anything reminding us of cooler fall weather was needed, so here came the idea of creating a Fall Quilt Garden from the Moda designs of Sandy Gervais, called "Awesome". This quilt uses every one of the 42 swatches from the Layer Cake and provides a variety of fall flowers scattered in field of soft white.
Hi, my name is Jamie with L' Fair Quilts, and I hail from the most southern part of Louisiana --- further south than New Orleans! I am a baby boomer closing in on retirement age (although no plans to leave a 36 year career in finance -- yet) and very excited to expand my quilting hobby. I have been watching the internet quilt world from afar and decided it was time to jump in head first. I started a blog this past January, and created a "hobby" pattern/quilt line under the name L'Fair Quilts (a play on my last name).
I hope you enjoy my first Moda Bake Shop submission and look forward to coming back again every so often to share my love of quilting.
- 1 Layer Cake, "Awesome" by Sandy Gervais (contains 42 - 10" x 10" swatches)
- 2 1/4 yards solid background, Moda Bella Snow (#9900-11)
- 1 1/4 yards orange solid by Sandy Gervais for inner border and binding
- 1 3/4 yards large print by Sandy Gervais for outside border (#17541)
- 4 1/2 yards backing
From Layer Cake:
- Cut each 10" x 10" fabric swatch into four 5" x 5" squares, yielding 42 sets of flower petals.
From Background Fabric:
- Cut 9 - 2" strips, subcut to 168 - 2" squares
- Draw a diagonal line on each of the 2" squares
- Cut 15 - 3 1/2" strips, subcut to 168 - 3 1/2" squares
- Draw a diagonal line on each of the 3 1/2 squares, and another line 1/2" apart (for snacks later in another project).
From Orange Solid:
- Cut 14 - 2 1/2" strips for inner border and binding, pieced diagonally to make inner border and binding:
- Subcut to 2 - 2 1/2" x 63 1/2" for sides
- Subcut to 2 - 2 1/2" x 58 1/2" for top and bottom
- Use remaining for binding
From Large Print:
- Cut 8 - 6 1/2" strips, pieced diagonnally to make outside borders
- Subcut to 2 - 6 1/2" x 67 1/2" for sides
- Subcut to 2 - 6 1/2" x 70 1/2" for top and bottom
Sew a 2" background square to the top right hand corner of each 5" square.
Trim each corner as pictured below and press open the background square.
Sew a 3 1/2" background square to the top left hand corner of each 5" square, then run a second stitch along the other drawn line.
Cut between the lines, press open (and don't forget to save those trimmed leftovers for snacks in future projects). If you have a chance to visit my blog later on, you may even find the quilt top I made with my leftovers!
Assemble each of the 42 flowers, sewing the top two petals, then the bottom two -- helpful hint: don't cut the thread between the top and bottom. When you sew the top and bottom together, the thread keeps the intersection in tact for a perfect matching of seams.
Open the center intersection (clip the little thread first) and press counter-clockwise.
- For the top, layout is 6 flower blocks across and 7 rows down.
- Add side inner borders, then add top and bottom inner borders.
- Add side outside borders, then add top and bottom inner borders.
- Layer top, batting, and backing .... quilt as desired!
A finished quilt measuring 70" x 79", with each finished flower measuring 9".
Jamie in Louisiana


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The page or resource you are looking for has either been moved or is no longer available on BeadStyleMag.com.
Use our site search to try and locate the requested page or follow one of our helpful links below.
Many flowers, like the chrysanthemum, bloom in the fall, bringing a bit of summer into the cooler autumn months. Carry that transitional beauty into your jewelry creations with these earrings. Design by Lori Anderson.


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Welcome to the used car and used BMW inventory page of Beverly Hills BMW. You'll see from our selection below that we have one of the best Los Angeles area used car inventories in the area, and we know that we have a used car, luxury car or SUV for you! If you're looking for pre owned luxury cars in Los Angeles, you need to come by. Take a look, and then call us with any questions; or stop by 5070 Wilshire Blvd. for a test drive.
Still looking for that perfect well-maintained pre-owned car? We will get you the used car in Los Angeles that you have been searching for. Just complete our no-obligation CarFinder form and we will alert you when a matching vehicle arrives at our dealership. Our Los Angeles car dealership also has a complete selection of new BMW cars to choose from. We are confident we can find the vehicle that satisfies all of your requirements.
Vehicle prices do not include additional fees and costs of closing, including government fees and taxes, any finance charges, any dealer documentation fees, any emissions testing fees or other fees. All prices, specifications and availability subject to change without notice. Images are representative of various models but may not be of any specific vehicle. Contact dealer for most current information. Protection Plan, backed by BMW, provides coverage for 2 years or 50,000 miles (whichever comes first) from the date of the expiration of the 4-year/50,000-mile BMW New Vehicle Limited Warranty. For more information, call 1-800-334-4BMW. ©2009 BMW of North America, LLC. The BMW name, model names and logo are registered trademarks.
Although we do our best to present the most accurate information available, we are not responsible for typographical errors that may occasionally occur.
Prices do not include government fees and taxes, any finance charge, any dealer document processing charge ($80), any electronic filing charge and any emission testing charge.


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Seattle's Best Blend Coffee (2 oz., 18 ct.)
by Seattle's Best | Item #: 882402 | (2) |
Designed to make a perfect pot of coffee, and premeasured for consistent full-flavor every time.
Seattle's Best Coffee portion packs feature a carefully crafted balance of 100% Arabica beans. They take pride in their ability to create coffees with the same bold flavor and smooth taste in every cup. The aroma and "nutty sweet" flavor of this coffee will entice all coffee drinkers. They are designed to make a perfect pot of coffee, premeasured for consistent full-flavor every time. The perfect solution for office coffee commercial makers.
- Requires filter (not included)
- 2.0 oz. per pack
- Makes 10-12 cups per pot of coffee
- Kosher certified
- 18 packs make 18 pots
- For commercial makers
- Labor saving, no mess
Assembled Country
Component Country
Ask & Answer
Warranty InformationThis product is covered by the Sam's Club Member Satisfaction Guarantee.
There is no additional information available for this item.


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Last Sunday was my first adventure into the world of Petapalooza and there were many expected sights and sounds, along with some that were much more unexpected.
I am a dog owner/dog lover. I have a just-over-two-years-old Scottish Terrier named Duffmahn. The only time he's needed to be rescued is in the presence of a larger, much more ferocious dog.
The dogs and cats at Holland's Petapalooza came in all shapes, sizes and ages, but they were all looking for the same outcome: a home to call their own. Some of them were rescued. Many were not.
Obviously there are many reasons someone can create to avoid pet ownership and many of those are valid. That being said, the pet mill business is also booming. This means people are still getting cats and dogs.
Petapalooza is a great way to thwart this. Shelters from across the southwest Michigan area set up booths at the event and brought many great dogs, one of which I nicknamed Chewbacca.
You can also contribute to the cause without actually buying an animal. Email Petapalooza at firstname.lastname@example.com or visit their Facebook page HERE.


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Physicians' Health Study
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
To assess the effect on cardiovascular mortality of alternate-day consumption of 325 milligrams of aspirin and, secondarily, the effect on cancer incidence of alternate-day consumption of 50 milligrams of beta-carotene.
Cardiovascular Diseases
Coronary Disease
Heart Diseases
Myocardial Ischemia
Drug: aspirin
Drug: carotene
Phase 3
|Study Type:
|Study Design:
|Allocation: Randomized
Masking: Double-Blind
Primary Purpose: Prevention
|Study Start Date:
|September 1981
|Study Completion Date:
|December 1996
|Primary Completion Date:
|December 1995 (Final data collection date for primary outcome measure)
Thrombosis plays a major role in the late stages of coronary occlusion. Platelet aggregation is a large component in the formation of arterial thrombi. In pharmacologic studies, aspirin has been shown to inhibit platelet aggregation and, therefore, might be expected to prevent coronary occlusion. These effects are apparent in the dose range of l00-l000 mg/day, and may be most evident at l60 milligrams daily. Higher doses seem to be no more effective in either inhibition of platelet agreeability or prolonged bleeding time.
Although an early case-control study by Jick and Miettinen showed a large benefit, most observational studies had shown a cardiovascular benefit of about 20 percent. Conclusive data could only result from a randomized trial with a large sample size.
Randomized, double-blind, fixed sample. Participants were randomized into one of four treatment groups: one 325 milligram aspirin tablet every other day, alternating with one 30 milligram capsule of beta-carotene; one aspirin every other day, alternating with one capsule of beta-carotene placebo; one aspirin placebo tablet every other day, alternating with one capsule of beta-carotene; and one aspirin placebo tablet every other day, alternating with one capsule of beta-carotene placebo. Major endpoints for the cardiovascular component of the study were cardiovascular mortality, total mortality, and coronary events.
|Ages Eligible for Study:
|40 Years to 84 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Male physicians, ages 40 to 84. No history of stroke, myocardial infarction, cancer, or renal disease. No contraindications to aspirin or beta-carotene. No current usage of aspirin or Vitamin A tables greater than once per week.
No Contacts or Locations Provided
Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:
|John Michael Gaziano, MD, Chief, Division of Aging, Brigham and Women's Hospital
|ClinicalTrials.gov Identifier:
|NCT00000500 History of Changes
|Other Study ID Numbers:
|Study First Received:
|October 27, 1999
|Last Updated:
|January 24, 2014
|Health Authority:
|United States: Federal Government
Additional relevant MeSH terms:
Cardiovascular Diseases
Myocardial Ischemia
Coronary Artery Disease
Coronary Disease
Heart Diseases
Vascular Diseases
Arterial Occlusive Diseases
Pathologic Processes
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Anti-Inflammatory Agents
Therapeutic Uses
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Cardiovascular Agents
Hematologic Agents
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
ClinicalTrials.gov processed this record on September 15, 2014


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Provincial Testing
Statement from Education Minister Jeff Johnson on the results of Provincial Achievement Tests and Diploma Exams
As we continue our work in building Alberta and realizing the vision of Inspiring Education, provincial assessments remain an integral part of our assurance to Albertans that our education system is performing well and supporting student learning. Provincial Achievement Tests (PATs) and diploma exams are one way of enabling Alberta Education—as well as parents, school authorities, superintendents, principals and teachers—to assess how well students are meeting provincial standards.
As part of this commitment, I am pleased to release the results of PATs and diploma exams for the 2012/2013 school year. The results of the tests remain steady, indicating that the majority of our students are continuing to perform strongly and developing a solid educational foundation to prepare them for their future world—whether that is in post-secondary studies or the workplace.
I know Albertans across the province are proud of our education system and its reputation for excellence. This excellence is based on our shared vision for continuously evaluating and working to improve our system. It's why we're moving forward with Curriculum Redesign, which involves a focus on literacy, numeracy, and competencies such as critical thinking and problem solving. It also includes changing assessment to better enable parents and teachers to understand student strengths or areas for improvement.
To this end, Alberta Education will begin phasing out PATs and piloting new Student Learning Assessments (SLAs) for Grade 3 students in September 2014. The new SLAs will better inform student learning by collecting valuable information at the beginning of the school year, while also including interactive approaches to help educators and parents understand how well students can apply what they have learned.
As you know, this past June, thousands of Alberta kids had to deal with some extraordinary challenges resulting from the devastation and evacuations caused by the southern Alberta floods, and our first priority was to ensure their safety and well-being. While we must be cautious about interpreting school and district results from flood-affected areas, individual results remain valid, and participation remained high enough that the province-wide information provides a valuable snapshot of how well our students are performing.
Once again, thank you to our education partners and to all Albertans committed to ensuring our kids have every opportunity to reach their full potential. We are proud to continue working with you in preparing a new generation of Albertans to become engaged thinkers and ethical citizens with an entrepreneurial spirit.
Jeff Johnson
Minister of Education
Highlights of provincial assessment results for 2012 - 2013
- Performance across English Language Arts 3, 6, 9, 30-1 and 30-2 remains steady at the acceptable level but is declining at the excellence level.
- Overall performance is consistent across French Language Arts 3, 6, 9, and 30-1.
- Results for Français 3, 6, 9, and 30-1 are consistent with those of previous years.
- Performance in Social Studies 6, 9, 30-1 and 30-2 remains consistent.
- Performance in Science 30, Chemistry 30, and Biology 30 continues to rise, while performance in Science 6, 9, and Physics 30 are consistent with last year after rising for four years.
- Trends in Math 3, 6, 9, 30-1 and 30-2 cannot be determined because five years of data based on the current program of studies does not yet exist.
- Participation in Grade 9 Provincial Achievement Tests was significantly impacted by the June 2013 flooding in Southern Alberta. Caution should be used when interpreting trends for specific groups or school boards affected by flooding.
- Participation in Math, Chemistry, Physics, and Science diploma exams was significantly impacted by the June 2013 flooding in southern Alberta. Caution should be used when interpreting trends for specific groups or school boards affected by flooding.
- Participation in English and Social Studies diploma exams was not affected by the floods.
- To ensure the safety of students, teachers, and staff, Alberta Education granted exemptions from diploma exams to students in flood-affected areas. More than 9,000 students received a total of more than 11,000 individual diploma exam exemptions. Roughly 20 per cent of exemption eligible students chose to write diploma exams despite the exemption.
- For students within affected areas who received an exemption from their diploma exam and chose not to write the exam, the student's school-awarded mark for June was considered final.
- Grade 9 Provincial Achievement Tests were cancelled in affected areas.
- School authorities affected by the exemptions were located primarily in southern and central Alberta.
Annual reports are provided province-wide for Diploma Examination Results for the entire school year; that is, for the November, January, April, June and August examinations combined. Additionally, these reports provide summaries of multiyear results as well as results by gender and for subgroups.
This section contains the Achievement Testing Results. Alberta Education and school authority personnel are responsible for ensuring that high-quality education is provided to all students in the province. Information about achievement is provided to schools and school authorities, parents, and the public, so that they may know how well students in their schools are meeting local targets and provincial expectations.
School and School Authority Results
This section contains a searchable database where you can get the multiyear reports for schools and jurisdictions that have had students write diploma examinations or achievement tests. You can search by school or school authority and by subject name.
Data Files (Microsoft Excel Format)
This section contains summary Excel files which contain results for diploma and achievement exams for all schools and authorities.
- Diploma Exam Results (Authority) (464 kb)
- Diploma Exam Results (School) (1,809 kb)
- Diploma Exam Results (Province) (11 kb)
- Diploma Exam Participation (Authority) (275 kb)
- Diploma Exam Participation (School) (1,221 kb)
- Diploma Exam Participation (Province) (7 kb)
- Achievement Exam Results (Authority) (5,000 kb)
- Achievement Exam Results (School) (29,869kb)
- Achievement Exam Results (Province) (118 kb)


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"Empire World Quilt Kit"
Product Rating:
Posted By:
Susan Pugh
Date Posted:
2012-07-17 16:23:26
I really like this quilt. In fact, I have ordered another kit to do. The only thing I found difficult about it was the fabrics were so close in color that I had to have a magnifying glass to make sure I had the correct fabric where it belonged. And of course, I did make a mistake with matching the fabrics, but found it in time to correct it. A small sample of each fabric with a corresponding letter would be a great help.
No-Sew Sisterly Love Fleece Blanket Kit
No-Sew Olaf Fleece Blanket Kit
Sisterly Love Quilt Kit
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A finger dislocation is when the a finger bone is knocked out of place. A dislocation also often involves stretching or damage to the ligaments. Ligaments are strong bands of fiber that help hold bones in place. Dislocation can happen in any of the finger joints.
A dislocated finger is usually caused by:
- A jamming force applied to the end of the finger
- Finger being forcefully twisted or bent
- Finger being overextended (bent backward)
Risk Factors
Factors that increase your risk of dislocation include:
- Contact sports
- Previous finger dislocation or sprain
- Medical conditions or disease that make ligaments weak or loose such as Ehlers-Danlos or Marfan syndrome
A dislocated finger may have:
- Severe pain
- Crooked or awkwardly bent shape
- Swelling and bruising in the injured area
- Numbness and/or tingling
- Inability to bend or straighten
The doctor will ask about your symptoms and how the injury occurred. The injured finger will also be examined.
Your doctor may order an x-ray . This can help rule out broken bones. It may also be used to make sure the bone is back in the correct place.
Emergency Care
Seek medical care right away. Do not try to put your finger bones back into place. If you wait for treatment, you could cause permanent damage.
The doctor will move the finger bones back into place. A local anesthesia may be used to help reduce pain. Your finger may then be placed in a splint or taped to the healthy finger. For severe injuries or ones that can not be moved back in to place by hand, a cast or surgery may be needed.
Home Care
You may still have swelling and discomfort after the doctor adjusts your finger. To help reduce swelling and pain try:
- Ice—Apply ice or a cold pack to your finger for 15-20 minutes, 3-4 times a day for several days. This helps reduce pain and swelling. Wrap the ice or cold pack in a towel. Do not apply the ice directly to your skin.
- Elevate—Try to hold the injured hand above the level of your heart. This is to help the swelling go down. For example, place your hand up on a pillow. Using a sling for a few days keeps the hand somewhat elevated.
- Over-the-counter medication—such as ibuprofen, naproxen, or acetaminophen
Once the pain is reduced, begin exercises to restore function and strength in your finger.
To help prevent a finger dislocation wear proper padding and safety equipment when participating in sports. Work with a coach or other professional to learn proper techniques and safety steps.
Revision Information
- Reviewer: Michael Woods, MD
- Review Date: 09/2013 -
- Update Date: 09/30/2013 -


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Funeral services for John Randall "Randy" Burrows, 59, will be held at 3 p.m. Saturday, April 6, 2013 at Rockett Funeral Home Chapel in Ringgold. Interment will follow at Providence Cemetery in Ringgold. Officiating the services will be Bro. Chuck Woodard.
Visitation is from 5 until 8 p.m. today (Friday, April 5, 2013) at Rockett Funeral Home.Subscribe to Read!


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The Competitiveness and Innovation Programme (CIP) promotes actions that address the challenges European industry is facing, with a special focus on the needs of small and medium-sized enterprises. The programme has been successful in meeting its main objectives according to a recent report, which highlights several of its achievements. Building on CIP's results, its funding successor – the new Programme for the Competitiveness of Enterprises and SMEs (COSME) - is expected to further strengthen and streamline actions in this field from 2014 onwards.


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Check your reservation, flight class details and so on; change your seat number.
Check in online or by phone within 24 hours of your departure
Track flight online or via SMS
Order an invoice for ticket purchased on lot.com or in Call Center.
Place an order
Enter Your e-mail address to get access to special offers and promotions not available anywhere else.


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Make our bed and breakfast / cabins your "base camp".
Sundance Bear Lodge is a country style bed and breakfast only 10 miles from the entrance to Mesa Verde National Park and 4 miles north of Mancos, Colorado. Bring your family, your dog and horse to enjoy 86 acres of mesa, forest and canyon just north of town, between Durango and Cortez. In addition to being so near Mesa Verde, we are 30 miles from Durango, CO and the Durango-Silverton railroad.
Absolutely, visit the cliff dwellings of Mesa Verde and learn the history of these Ancestral Puebloans that built 4 story "apartment buildings" in the 1200s. Marvel at how they accomplished this civilization without metal, the wheel or a written language.
Then return to Sundance Bear Lodge and escape everything neutral. Find peace for your soul while astride a quarter horse in a high mountain meadow. Absorb the vibrant colors in southwest Colorado! Listen to a thunderstorm; see the blue sky by day turning to pink, purple and flame red at sunset, then the stars of night! Southwest Colorado casts a spell!
Walk in the shoes of the Anasazi at Mesa Verde - there WAS history before Columbus! Imagine the outlaw days of Butch Cassidy and the Sundance Kid & the life of mountain miners. Mancos, CO was the breadbasket for the workers in the area in the late 1800s. Today, ride horseback in the gorgeous La Plata mountains and spend a day on the Durango-Silverton narrow gauge railroad. Shop our galleries in Mancos. Then save time for stunning sunsets – pull up a chair on the deck or hop in the hot tub.


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Chto Delat? Poster Timeline
Here we collected a series of (mostly) retrospectively made posters which reflect different aspect of our activity with a focus on less visible parts of it.
Chto Delat? / What is to be Done?
The collective Chto Delat (What is to be done?) was founded in early 2003 in Petersburg by a workgroup of artists, critics, philosophers, and writers from St. Petersburg, Moscow, and Nizhny Novgorod with the goal of merging political theory, art, and activism.
The group was constituted in May 2003 in St. Petersburg in an action called "The Refoundation of Petersburg." Shortly afterwards, the original, as yet nameless core group began publishing an international newspaper called Chto Delat?. The name of the group derives from a novel by the Russian 19th century writer Nikolai Chernyshevsky, and immediately brings to mind the first socialist worker's self-organizations in Russia, which Lenin actualized in his own publication, "What is to be done?" (1902). Chto Delat? sees itself as a self-organized platform for a variety of cultural activities intent on politicizing "knowledge production" through redefinitions of an engaged autonomy for cultural practice today.
The array of activities is coordinated by a core group including following members:
Tsaplya Olga Egorova (artist, Petersburg), Artiom Magun (philosopher, Petersburg), Nikolay Oleynikov (artist, Moscow), Natalia Pershina/Glucklya (artist, Petersburg), Alexey Penzin (philosopher, Moscow), David Riff (art critic, Moscow), Alexander Skidan (poet, critic, Petersburg), Oxana Timofeeva (philosopher, Moscow), and Dmitry Vilensky (artist, Petersburg). In 2012 the choreographer Nina Gasteva has joined a collective after few years of intense collaboration. Since then many Russian and international artist and researchers has participated in different projects realized under the collective name Chto Delat? (see descriptions of each projects on this web site)
new issue of the Bulletin of the School for Engaged Art is on-line
works as a reader to the public programm of our school in a days of the opening of Manifesta
see all programm here https://www.facebook.com/events/798442093513033/?ref_newsfeed_story_type=regular
Border Musical – full on-line version of the new film
border musical (web version) – a film by Chto Delat from chto delat on Vimeo.
Ola from Finnmark meets Tanja from Kola. They fall in love, Tanja abandons her past and moves with her son to her new husband. Through joys and challenges of their mixed marriage we get a glimpse into today's Russia-Norwegian borderland across cultural and social norms and values. How our behaviour and worldview are influenced by culturally laden relations between individual, family and society? To what degree we are responsible for our actions and to what degree we leave it to the state? Who defines areas of responsibility? The Norwegian state and Ola's best friend help the couple to build up a family based on thesound Norwegian values.
BORDER MUSICAL is not a description of the reality; it is a reality served in a spicy manner: through polished language and sharp definitions, exaggerated images and multifaceted characters, bizarre movements and eccentric scenes. Why cheer a mutual understanding when we learn from our differences?
Director: Tsaplya Olga Egoraova
Idea, Screenplay, Set and Edit: Tsaplya Olga Egoraova and Dmitry Vilensky in cooperation with Jesper Alvær.
Composer: Mikhail Krutik.
Director of Photography: Artyom Ignatov.
Cast: Anna Bulavina, Haldor Lægreid, Ketil Høegh, Maryon Eilertsen, Kristine Henriksen, Camilla Wiig Revholt, Ann Christin Elverum, Egor Semenkov, Nikolay Kurbatov, Mikhail Baranov, Andrey Molodchinin.
Choreographer: Nina Gasteva.
Producer: Pikene på Broen in cooperation with KORO, Bergen Assembly, FilmCamp, Filmgården and many others.
Run time: 48:30 min.
created by the collective Chto Delat for Barents Spektakel 2013.