text:
Treatment for Advanced Liver Cancer Increases Survival
The targeted drug sorafenib (Nexavar) has improved the survival of patients with advanced liver cancer, a fatal disease that is becoming more common worldwide.
The final-stage, randomized study found that patients taking sorafenib lived nearly 3 months longer than patients taking a placebo. This was clinically significant, and the trial was stopped early because preliminary results clearly favored sorafenib. Read more
ASCO 2007: Steady Progress Against Cancer
On June 1-5, Chicago played host to this year's American Society of Clinical Oncology (ASCO) meeting. This year set an attendance record with more than 30,000 participants. Throughout the meeting one sensed the excitement of steady, continued progress. There was also anticipation of even greater changes that will occur in the coming years as laboratory science is enabled by new and rapidly evolving technology. The anticipation was clearly about earlier diagnosis, new and reliable biomarkers, highly characterized tumors, and more targeted therapies.
For example, as the lead story in this issue of the NCI Cancer Bulletin discusses in greater detail, a phase III European clinical trial found that, compared with placebo, the multitargeted agent sorafenib (Nexavar) improves survival in advanced hepatocellular carcinoma (HCC). There was a small, but statistically significant, improvement, marking the first time a systemic treatment has proven effective against advanced HCC, a notoriously intractable disease that is increasing in incidence in the U.S. The result clearly sets the stage for further trials testing sorafenib in combination with other targeted agents to treat HCC. Read more
Treatment for Advanced Liver Cancer Increases Survival
The targeted drug sorafenib (Nexavar) has improved the survival of patients with advanced liver cancer, a fatal disease that is becoming more common worldwide.
The final-stage, randomized study found that patients taking sorafenib lived nearly 3 months longer than patients taking a placebo. This was clinically significant, and the trial was stopped early because preliminary results clearly favored sorafenib.
"For the first time we have a drug that works for these patients," said Dr. Joseph Llovet of the Mount Sinai School of Medicine and the University of Barcelona. He presented the results June 4 at the American Society of Clinical Oncology (ASCO) annual meeting.
Sorafenib is a pill that patients can take at home. The drug, which is approved for kidney cancer, was well tolerated by the 602 patients in the international study. The most common side effects included diarrhea and skin reactions in the hands and feet.
Dr. Llovet noted that there have been more than 100 unsuccessful clinical trials for advanced liver cancer in the last 30 years. Surgery and chemotherapy are used to treat patients in the earlier stages of disease, but there has been no successful "systemic" treatment, such as a drug, for advanced cases.
Sorafenib will now become the standard treatment for patients with advanced liver cancer, and having this regimen as a platform will accelerate clinical trial efforts to identify other agents, said Dr. A. William Blackstock of the Wake Forest University School of Medicine at the meeting.
Until now, experimental therapies for liver cancer have been compared with placebos. Many patients, particularly in the U.S., are reluctant to join clinical trials if they have a 50-percent chance of receiving a sugar pill. Participation in trials may now increase, with sorafenib replacing placebos as the standard control.
"We can now move forward in this disease," said Dr. Blackstock.
The next steps include testing sorafenib earlier in the disease and eventually in combination with other targeted therapies. Bevacizumab (Avastin), erlotinib (Tarceva), and sunitinib (Sutent) have all been tested for liver cancer in phase II studies.
Like these drugs, sorafenib interacts with a small number of proteins. The drug inhibits cell growth and the formation of blood vessels that feed tumors (angiogenesis).
Liver cancer is the fifth most common cancer and the third leading cause of cancer death worldwide. The disease is most prevalent in the developing world, but it appears to be increasing in the U.S. and Europe.
In the trial, the sorafenib group lived on average 10.7 months compared with 7.9 months for the placebo group - a more than 40-percent improvement in survival time.
Sorafenib is the "first convincing and rigorously tested treatment" to show a survival benefit for these patients, said Dr. Philip James Johnson of the Institute for Cancer Studies at Birmingham University in the U.K., who discussed the results in a special session at ASCO.
Dr. Johnson cautioned that it is not yet known how the drug might perform in different ethnic groups and in patients with poor liver function. Most participants were European and had relatively good liver function.Nonetheless, he concluded, the study marks "the dawn of a new era" in the treatment of liver cancer.
- Edward R. Winstead
ASCO 2007: Steady Progress Against Cancer
On June 1-5, Chicago played host to this year's American Society of Clinical Oncology (ASCO) meeting. This year set an attendance record with more than 30,000 participants. Throughout the meeting one sensed the excitement of steady, continued progress. There was also anticipation of even greater changes that will occur in the coming years as laboratory science is enabled by new and rapidly evolving technology. The anticipation was clearly about earlier diagnosis, new and reliable biomarkers, highly characterized tumors, and more targeted therapies.
For example, as the lead story in this issue of the NCI Cancer Bulletin discusses in greater detail, a phase III European clinical trial found that, compared with placebo, the multitargeted agent sorafenib (Nexavar) improves survival in advanced hepatocellular carcinoma (HCC). There was a small, but statistically significant, improvement, marking the first time a systemic treatment has proven effective against advanced HCC, a notoriously intractable disease that is increasing in incidence in the U.S. The result clearly sets the stage for further trials testing sorafenib in combination with other targeted agents to treat HCC.
Also impressive was a larger, phase III clinical trial that showed a significant treatment benefit against another difficult to treat disease, small-cell lung cancer (SCLC). Using prophylactic cranial irradiation, or PCI, in patients with extensive SCLC who had responded to chemotherapy, not only was the risk of symptomatic brain metastases reduced compared to those not receiving PCI, but there was a highly significant survival improvement at one year. There seemed to be consensus at the meeting that this finding should immediately change clinical practice.
After demonstrating particularly powerful prognostic prowess in metastatic breast cancer, new data presented at ASCO suggested that levels of circulating tumor cells (CTCs) - tumor cells circulating freely in blood - in men with metastatic, hormone-refractory prostate cancer are predictive of prognosis and response to chemotherapy. This new study also suggests CTC levels may be a better surrogate of treatment efficacy than PSA levels.
During the meeting, preliminary data were presented from the first prospective, multicenter phase II clinical trial in the U.S. testing gefitinib (Iressa) as a first-line therapy in patients with advanced non-small-cell lung cancer with genetic mutations known to correspond with gefitinib response. The initial findings demonstrated strong progression-free survival, and the estimated median overall survival of approximately 21 months would be a significant improvement compared with historical rates. The trial, called iTARGET, represents an important step toward more individualized treatment.
Finally, it is important to touch on the results of a small, but entirely new type of clinical trial being pioneered at NCI that we believe will ensure promising agents get translated to the clinic more quickly and efficiently than in the past. Following new FDA guidance released last year - and developed with the aid of the FDA-NCI Interagency Oncology Task Force - this "early phase I trial" involved only six patients. It tested an inhibitor of an enzyme called PARP that plays a critical role in DNA repair. Assays developed as part of the trial showed that the agent, ABT-888, was hitting its intended target in tumor cells, as well as in white blood cells, suggesting that future early-phase trials of the drug can use white blood cells as biomarkers of the compound's effectiveness.
Just before the ASCO meeting began, NCI's Scientific Director for Clinical Research, Dr. Lee Helman, participated in a meeting with the Sarcoma Alliance for Research through Collaborations to review the findings from phase I clinical trials testing investigational monoclonal antibodies that inhibit IGF-1R, including some extremely promising results seen in patients with Ewing's sarcoma, a cancer rare in adults but common in children. In some cases, there have been complete responses in patients with refractory, progressive disease who had failed multiple therapies. Based on these results, several phase II studies have been planned, at least one of which is scheduled to launch in the fall. I am very hopeful that positive results of these trials may be presented at future ASCO meetings.
This year's ASCO meeting demonstrated the important progress being made against different cancer types through varied approaches. It demonstrates how we are learning to design better trials and take advantage of new technologies. Most important, it confirms that we are improving outcomes for more and more people who receive a cancer diagnosis.
Dr. John E. Niederhuber
Folic Acid Study Shows Surprising Results
A study that set out to test folate for prevention of early-stage colon cancer instead found a higher incidence of colorectal adenomas in the test group. This multi-institutional NCI-funded research, performed by the Polyp Prevention Study Group, appeared in the June 6 Journal of the American Medical Association.
The cohort included 987 people who had a history of colorectal adenomas, precursor lesions for cancer. Half of these people received 1 mg/day of folic acid and the other half received a placebo. The average person gets about 0.2 - 0.4 mg of daily folate in their diet. Participants were monitored with colonoscopies after 3 and 5 years.
With an average follow-up of 3 years, colorectal adenomas occurred in 42.4 percent of participants who received the placebo and in 44.1 percent of those who received folic acid. At the 5-year follow-up, participants in the folic acid group also had higher rates of advanced lesions and greater numbers of lesions than the control group.
An accompanying editorial speculates that the most likely explanation for this increase in advanced lesions (known precursors to colorectal cancer) is that they are promoted by increased folate.
The editorial also notes that a history of colorectal adenomas was a prerequisite for inclusion in the study, and the endpoint was whether additional adenomas formed, not whether cancer was prevented in this high-risk group. "The question of efficacy of folate in cancer prevention is not resolved…Animal experiments showing chemopreventive effects of folate, as well as the strong observational epidemiological evidence, speak to [its] potential…if taken early," the editorialists wrote.
Meta-Analysis Suggests Cisplatin Superior to Carboplatin for Advanced NSCLC
Cisplatin is likely a better option than carboplatin for patients with advanced-stage non-small-cell lung cancer (NSCLC), according to a meta-analysis of nine randomized clinical trials comparing the two drugs.
The analysis, which involved data on nearly 3,000 individual patients, revealed a superior response rate in patients with NSCLC treated with a cisplatin-based chemotherapy regimen compared with carboplatin-based regimens, and a small but statistically significant improvement in overall survival in patients with nonsquamous NSCLC and those in whom cisplatin was combined with so-called third-generation chemotherapy drugs, such as gemcitabine, paclitaxel, and docetaxel.
"The superiority of cisplatin over carboplatin was not achieved at the cost of a statistically significant increase in the incidence of severe side effects," wrote lead author Dr. Andrea Ardizzoni, of University Hospital in Parma, Italy, and colleagues in the June 6 Journal of the National Cancer Institute (JNCI). They reported that, while cisplatin-based regimens were associated with a greater incidence of high-grade nausea, vomiting, and kidney problems, carboplatin was associated with more drastic drops in platelet counts (thrombocytopenia).
Based on clinical trial results, the two drugs have been considered to be equally effective in treating advanced NSCLC, and U.S. oncologists have favored carboplatin because it has been associated with fewer side effects and is easier to administer.
In an accompanying editorial in JNCI, Dr. Christopher G. Azzoli, from Memorial Sloan-Kettering Cancer Center, and colleagues noted that more effective antinausea medications could help to decrease cisplatin's toxicity burden. They also cited cisplatin's increased effectiveness in patients with nonsquamous disease, which they argued was particularly important given the success seen in a recent U.S. phase III study in the same patient population treated with a combination of the targeted agent bevacizumab (Avastin) and carboplatin and paclitaxel.
Overall, the editorial states, "the apparent superiority of cisplatin over carboplatin…should not be taken lightly, particularly in patients being treated with a curative intent."Meanwhile, a European phase III trial presented at the ASCO annual meeting found that combining bevacizumab with cisplatin and gemcitabine provides a slight improvement - less than a month - in median progression-free survival compared with chemotherapy alone.
Preventive Radiation Reduces Lung Cancer Brain Metastases
According to results recently presented at the ASCO annual meeting, prophylactic cranial radiation following treatment with chemotherapy doubles survival at 1 year and reduces the risk of developing brain metastases among patients with extensive-disease small-cell lung cancer (SCLC).
About 70 percent of SCLC patients have disease that has already spread extensively at the time of their diagnosis, and a significant number of patients develop brain metastases. Previous studies have shown that prophylactic cranial irradiation (PCI) prevents brain metastases and improves survival in SCLC patients who have local disease and a complete response to initial chemotherapy. New results presented at the ASCO meeting indicate that this strategy remains sound, even when SCLC has spread extensively.
Findings were presented by lead author Dr. Ben Slotman of the VU University Medical Center in Amsterdam. The trial randomized 286 patients who had responded to 4 to 6 cycles of chemotherapy to observation or PCI consisting of 20 to 30 Gy administered in 5 to 12 fractions. At 1 year, symptomatic brain metastases occurred in 14.6 percent of patients treated with cranial radiation compared with 40.4 percent of patients in the observation group. Survival was doubled at 1 year for patients treated with cranial radiation compared with those in the observation group (27.1 versus 13.3 percent, respectively). Radiation was well tolerated and the most common side effects were headache, nausea and vomiting, and fatigue.
Children Survive Neuroblastoma with Less Intensive Treatment
On Sunday, June 3, researchers from the Children's Oncology Group presented results at the ASCO annual meeting from a multinational study showing that a treatment regimen more patient-friendly than the current standard can achieve comparable survival rates among infants and children with intermediate risk neuroblastoma.
Researchers substituted carboplatin for cisplatin, a drug that can cause long-term side effects such as hearing loss, in the multi-agent drug treatments that they administered to study patients. They also reduced the length and number of cycles so that patients received 10 to 18 days of treatment over an 84- to 168-day period, as opposed to the standard 71 days of treatment over 286 days. The researchers compared the survival rate achieved by the new treatment with that observed for prior clinical trials of standard treatments.
After an average follow-up of 3 years, survival among the 467 infants and children was 96 percent, which is comparable to or better than that seen in large trials of standard treatment. Furthermore, less than 2 percent of the patients had major damage to their heart, kidney, liver, or hearing - a better than usual outcome.
"The paradigm we are continually striving for is to cure as many children as possible while reducing the burden of treatment," said the study's lead author, Dr. David Baker of Princess Margaret Hospital for Children in Perth, Australia, in an ASCO press briefing. "This goes a long way toward meeting that goal."
Kidney Cancer Patients Benefit from Avastin
Bevacizumab (Avastin) is the fourth targeted drug in recent years to help patients with advanced kidney cancer, a disease that historically has been difficult to treat. A final-stage, randomized trial presented at the ASCO annual meeting found that the combination of bevacizumab and interferon was more effective than interferon and placebo. Adding bevacizumab nearly doubled the time the disease took to progress - from 5.4 months to 10.2 months - without creating significant new toxicities.
Interferon was the standard treatment for advanced kidney cancer when the trial began. But last year three targeted drugs - sunitinib (Sutent), sorafenib (Nexavar), and temsirolimus (Torisel) - emerged as the first new kidney cancer medicines in two decades, changing the standard of care. The new results demonstrate for the first time that bevacizumab, which is approved for advanced colorectal and non-small-cell lung cancers, is also effective against kidney cancer.
"The benefits of bevacizumab and interferon were greater than we expected," said lead investigator Dr. Bernard Escudier of the Gustave Roussy Institute in France. "We now need studies to compare the different therapies." Bevacizumab will likely be tested as a single agent against the other therapies in the coming years, he said.
The response rate in the trial of 649 patients was 31 percent for the bevacizumab group compared with 13 percent for the placebo group. After an interim analysis showed a clear benefit, all patients were offered the bevacizumab combination. Preliminary data suggest that bevacizumab may prolong survival, but additional studies are needed.
Combinations of targeted therapies may be needed to achieve the maximum benefit for patients. Toward this end, an early-stage clinical trial presented at ASCO showed that some patients tolerated a combination of sunitinib and bevacizumab. As dosage information becomes available, the combination may be appropriate for phase II trials in metastatic renal cell carcinoma as well as other cancers, the researchers said.
Cetuximab Extends Survival in Recurrent Head and Neck Cancer
Cetuximab (Erbitux), a monoclonal antibody targeting the epidermal growth factor receptor, has proven effective in treating several kinds of head and neck cancer. It was approved last year by the FDA for initial treatment of advanced squamous cell carcinoma of the head and neck (SCCHN). Researchers at last week's ASCO meeting reported the results of the European EXTREME trial, and added to accumulating evidence that cetuximab also has a role in treating the disease when it recurs or metastasizes.
Lead author Dr. Jan B. Vermorken from the University of Antwerp in Belgium called the survival benefit - a 21-percent risk reduction with cetuximab patients surviving 10.1 months, 2.7 months longer than those receiving standard care - "among the longest ever seen in a large clinical trial among these patients." For more than two decades, progress in this setting had plateaued. Patients with recurrent or metastatic SCCHN usually receive platinum-based, palliative chemotherapy, sometimes with an intent to cure, but most do not survive beyond 6 to 7 months.
All 442 patients received standard care: up to six cycles of chemotherapy with 5-fluorouracil plus either carboplatin or cisplatin. The experimental group also received cetuximab, until the disease progressed or unacceptable toxicity levels were reached. The most common side effect associated with cetuximab was a controllable rash.
Shark Cartilage Ineffective Against Lung Cancer
A clinical trial to rigorously evaluate shark cartilage as a cancer therapy found no benefits for patients. Lung cancer patients who took AE-941 (Neovastat) along with chemotherapy and radiation lived no longer than patients who did not (about 15 months), researchers reported at the ASCO annual meeting. The final-stage clinical trial was cosponsored by NCI and included 384 patients.
Physicians know that many cancer patients consume natural products that have not been scientifically tested and that may interact with conventional treatments. The cartilage study was designed to see whether a natural product developed as a pharmaceutical and put through standard clinical testing might benefit cancer patients. Unlike the products sold in stores and over the Internet, AE-941 was available only through the trial.Early testing suggested that the drug may block the growth of blood vessels that feed tumors, but in the end the results were negative. "AE-941 is not an effective therapeutic agent for lung cancer," said lead investigator Dr. Charles Lu of the University of Texas M.D. Anderson Cancer Center.
Slowly but Surely, Turning Science into Medicine
The theme of this year's ASCO annual meeting was "Translating Research into Practice." The phrase is open to interpretation, but many would agree that translation is an art, not a science, and that it usually takes a long time.
Consider the example of Met, a gene discovered at NCI in the early 1980s. Two decades later, the gene has emerged as an important player in a variety of cancers, including lung, gastric, and melanoma. Many companies are developing drugs to block signals from the Met protein, which can drive cells to grow and spread.
Whether any of these drugs will be safe and effective is an open question. But studying Met has led to new insights into how cells communicate and what can go wrong in cancer, making it a model for developing targeted therapies.
At the meeting, many researchers got their first look at clinical results for Met inhibitors. The news was positive. Two drugs - one developed by ArQule (called ARQ 197) and another by Exelixis (called XL880) - may have benefited some patients and were well tolerated.
"These are two interesting novel agents and both have encouraging antitumor activity," said Dr. Francisco Esteva of the University of Texas M. D. Anderson Cancer Center, who discussed the presentations at the meeting.
Each drug was tested against multiple cancers, and the drugs themselves were different: ARQ 197 inhibits Met alone, while XL880 inhibits Met and another signaling protein, VEGFR2.
Met plays an important role in early development. But the gene is less active later in life, and this helps make it an attractive therapeutic target.
In one XL880 trial, several patients with papillary renal cell cancer appeared to respond. This disease is difficult to treat and can occur because Met is mutated or amplified (extra copies of the gene are present in a cell).
The results are "exciting," said Dr. George Vande Woude, whose laboratory at NCI discovered Met and led the early work on the gene. "This is some of the first evidence that the strategy of inhibiting Met is working in the clinic."
Dr. Vande Woude now directs the Van Andel Research Institute in Grand Rapids, MI, which maintains an online database of studies on Met (technically called c-Met) and cancer. Collectively, the studies tell the story of Met research and provide an indication of how much time and money may be required to take a discovery from the laboratory to the clinic.
"Translation takes time, and there is no shortcut," commented Dr. Vande Woude. He noted that work on trastuzumab (Herceptin), one of the successful new targeted drugs, began shortly before Met was discovered.
For many years, drug developers thought that inhibiting Met might affect the liver or other organs, but research eventually allayed these concerns. "Various groups then moved forward aggressively with Met inhibitors," said Dr. Bart Lutterbach of Merck, who studies Met in lung and gastric cancers.
Mutations and amplifications of Met may be relatively rare in many cancers, noted Dr. Lutterbach. But for patients whose tumors depend on Met signaling, blocking these signals will be necessary to treat the disease.
The Met protein, which sits on the surface of cells, is a tyrosine kinase receptor. Other members of this family include the targets of gefitinib (Iressa) and imatinib (Gleevec).
Over the last 20 years Met has been a tool for understanding how kinase receptors can be deregulated, said Dr. Morag Park of McGill University, who discovered the gene while working with Dr. Vande Woude at NCI.
"Met has led us to a much deeper understanding of signaling pathways involved in cancer," she added. "The important question to ask about Met now is whether it works in a synergistic way with other signals involved in cancer."
Dr. Park predicted that considerable "crosstalk" among signaling pathways will be found in cancer cells when the studies are possible.
A striking example of this phenomenon may have been discovered recently in lung cancer. When the signaling protein EGFR was blocked by a drug, lung cancer cells simply amplified Met to take its place and rendered the drug useless, researchers reported in the April 26 Science.
In light of this cooperation, a comprehensive understanding of how signals are transmitted in cells may be required to treat some cancers. And patients may one day take multiple drugs, as HIV patients do, in an effort to prevent resistance.
"By using combinations of targeted therapies, it should be possible to reduce the likelihood that tumors can escape the control of individual drugs," said Dr. Vande Woude.
At the same time, Met inhibitors may work synergistically with other inhibitors. Dr. Ravi Salgia of the University of Chicago and his colleagues have tested a Met inhibitor that cooperated with the drug rapamycin in some tumors.
Dr. Salgia is now focusing on how to identify lung cancer patients who may benefit from anti-Met therapy. These patients would have increased Met activity as a result of mutations, amplifications, or perhaps drug resistance.
"There are a lot of unanswered questions we need to figure out," said Dr. Salgia. "But working to understand pathways such as Met may open windows of opportunity for other therapies."
Phase II trials are underway for XL880, and positive results have been reported. Many other experimental agents are waiting in the wings.
"We need to move forward with these agents because they are the next generation of cancer therapies," said Dr. Patricia LoRusso of the Barbara Ann Karmanos Cancer Institute in Detroit, who presented results on XL880 at ASCO."We are finally starting to turn science into medicine, and it's exciting," she added.
- Edward R. Winstead
Dietary and Herbal Therapy for Brain Cancer
Name of the Trial
Principal Investigator
Why This Trial Is Important
Resin from the Boswellia serrata tree (frankincense) has been shown in animal and human studies to reduce inflammation, which is a primary cause of brain edema. Additionally, laboratory studies suggest that B. serrata resin may also cause human brain cancer cells to undergo programmed cell death (apoptosis).
In this trial, patients will be randomly assigned to take an herbal preparation of B. serrata orally four times a day and eat a low-fat vegan diet for 6 months or to eat a normal low-fat diet for 6 months. Vegan diets lack arachidonic acid, a chemical found in meat that is converted in the brain to signaling molecules called eicosanoids that may promote inflammation and tumor growth. Doctors want to see if B. serrata and a vegan diet can help reduce brain edema, tumor growth, and levels of 5-lipoxygenase, an enzyme that helps convert arachidonic acid to eicosanoids, in these patients.
"Some small studies have suggested that frankincense extract may help limit brain edema and even have an anti-tumor effect," said Dr. Stevens. "We hope that dietary changes in conjunction with use of this herbal preparation will help improve patient outcomes and act in a complementary fashion with standard treatments for high-grade gliomas."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
CCR Intern Wins Intel Foundation Award
Mr. Li, under the guidance of Dr. David D. Roberts, worked with cells from the inside of human umbilical veins to examine the effects of thrombospondin-1 (TSP1) and nitric oxide (NO) on angiogenesis. His objective was to determine how to inhibit this process, which is essential to tumor growth and metastasis. He found that when TSP1 was combined with NO, the reaction switched from inhibitory to stimulatory.
The Intel event is the world's largest precollege celebration of science. Held annually in May, the Intel ISEF brings together nearly 1,500 students from more than 40 nations.
Free Telephone Workshop for Cancer Survivors
This free series offers cancer survivors, their families, friends, and health care professionals practical information to help them cope with concerns and issues that arise after treatment ends. Parts I and II of the series are available as podcasts on the CancerCare Web site.
If Memory Serves...
With the encouragement of NCI representatives, in 1939, seven U.S. states began to include cancer control in their health departments' missions; three states established cancer commissions. NCI also began to distribute information on cancer for public education, and produced a movie for this purpose with the help of the American Society for Control of Cancer that was designed for nonscientific viewers. Eventually, the Institute published "What to Know, What to Do about Cancer" - a prelude to NCI's "What You Need to Know About..." series - and distributed 48,000 copies for free. Read more)
For more information about the birth of NCI, go to http://www. cancer.gov/aboutnci/ncia.
NCI Helps Create Radiation Emergencies Management Web Site After months of development by an interagency team that included two NCI experts, a unique Web site was unveiled on March 8 by the Department of Health and Human Services (HHS). The Radiation Event Medical Management (REMM) site was established to provide just-in-time information for diagnosis and treatment guidance to health care providers - primarily physicians - who do not have formal radiation medicine expertise. In the event of mass casualties during a radiological and/or nuclear event, REMM is a one-stop, algorithm-based response, backed by an exhaustive catalog of information and links to relevant Web sites. The Web-based system can be downloaded in advance of such an emergency where Internet access might be compromised. The information has been vetted by some 45 subject experts in the fields involved.
The site emerged from work at the Office of Preparedness and Emergency Operations in the Office of the Assistant Secretary for Preparedness and Response at HHS. Dr. Norman Coleman of NCI's Division of Cancer Treatment and Diagnosis was the team leader; Dr. Judith L. Bader, Captain, USPHS, of NCI's Office of Communications and Education is the managing editor of REMM.
NCI Releases New Tobacco Control Monograph
Salk Institute for Biological Studies Cancer Center
Director: Dr. Walter Eckhart • 10010 North Torrey Pines Road, La Jolla, CA 92037 • Phone: 858-453-4100 ext. 1386 • Web site: http://www.salk.edu
Today, Cancer Center investigations comprise approximately half of the research conducted by the Salk Institute and occupy more than 60,000 square feet of laboratory space within the original campus. This research supports 22 faculty members, 150 postdoctoral researchers, 45 graduate students, and 80 research assistants.
Research Activities
The Salk Institute Cancer Center currently focuses on three research areas: molecular biology and genetics, growth control, and cell and developmental biology. Within these areas, scientists are studying signal transduction pathways using phosphorylation and ubiquitination that regulate cell size and cell proliferation in normal cells, cancer cells, and animal models; the functions of tumor suppressor proteins, including p53, LKB1, and APC; the response of cells to DNA damage and how this is perturbed in cancer cells; the involvement of telomere dysfunction in cancer; the connections between aging and cancer; and the role of stem cells in cancer.
Other Notable Programs
Research underway in the Cancer Center is supported by competitively awarded grants of approximately $16 million. In addition, Cancer Center members have been working with The Genomics Institute of the Novartis Research Foundation to carry out genome-wide screens, and the Salk Institute is part of the San Diego Consortium for Regenerative Medicine, which has plans to establish a facility that will serve the La Jolla mesa area, funded in part by the California Institute for Regenerative Medicine (CIRM). Most recently, the Salk Institute received a $2.3 million facilities grant from CIRM to fund the development of shared laboratory space where investigators will conduct scientific research on human embryonic stem cells.
NCI recently designated two new Cancer Centers: Stanford Comprehensive Cancer Center and the Dan L. Duncan Cancer Center at Baylor College of Medicine.
Following are newly released NCI research funding opportunities:
Community Clinical Oncology Program
This is a renewal of RFA-CA-07-025 and will use the U10 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3730. Inquiries: Dr. Lori Minasian - email@example.com
Minority-Based Community Clinical Oncology Program
This is a renewal of RFA-CA-07-025 and will use the U10 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3731. Inquiries: Dr. Worta McCaskill-Stevens - email@example.com
A Data Resource for Analyzing Blood and Marrow Transplants
This funding opportunity will use the U24 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3732. Inquiries: Dr. Roy S. Wu - firstname.lastname@example.com
NCMHD Community-Based Participatory Research Initiative in Reducing and Eliminating Health Disparities: Intervention Research Phase
This funding opportunity will use the U24 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3733. Inquiries: Dr. Kenneth Chu - email@example.com
Omics and Variable Responses to CAM: Secondary Analysis of CAM Clinical Trials
This funding opportunity will use the R01 (PAR-07-377) and R21 (PAR-07-378) award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3735. Inquiries: Dr. Nancy Emenaker - firstname.lastname@example.com
Behavioral and Social Science Research on Understanding and Reducing Health Disparities
This funding opportunity will use the R01 (PAR-07-379) and R21 (PAR-07-380) award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3736. Inquiries: Dr. Shobha Srinivasan - firstname.lastname@example.com
Biology of Breast Pre-Malignancies
This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3729. Inquiries: Anne S. Tatem - firstname.lastname@example.com


text:
Pharmacogenomic Study of Neoadjuvant Eribulin for HER2 Non-overexpressing Breast Cancer (NeoEribulin)
This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2013 by SOLTI Breast Cancer Research Group
SOLTI Breast Cancer Research Group
Eisai Inc.
Information provided by (Responsible Party):
SOLTI Breast Cancer Research Group
ClinicalTrials.gov Identifier:
First received: August 9, 2012
Last updated: February 11, 2013
Last verified: February 2013
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
No Study Results Posted on ClinicalTrials.gov for this Study
|Study Status:
|This study is currently recruiting participants.
|Estimated Study Completion Date:
|August 2017
|Estimated Primary Completion Date:
|August 2014 (Final data collection date for primary outcome measure)

subset: commoncrawl


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Motel Suri Floral Print Playsuit
This gorgeous playsuit by Motel is perfect for partying this summer with it's rich colour and stunning fit.
Featuring an all-over floral print, this playsuit shows off your flirty side, while the full sleeves keep your look elegant. Getting you ready for the weekend is the wrap style front with a deep plunge neckline and short shorts that show off your polished pins. The elasticated waist cinches your middle, while two side pockets add a little laid back cool to your look.
Wear this playsuit with a pair of barely there sandals, bling accessories and smoky eyes for a sultry finish.
Dressing to impress is part of the Motel girl's fashion M.O so go for your usual size for a figure-hugging fit that showcases your curves or a size up for a fit that skims your silhouette gorgeously.
Useful info:
- Playsuit by Motel
- All-over floral print
- Full sleeves
- Wrap front
- Elasticated waist
Motel Virgo Metallic Dress
- In Stock
1 review
- Delivery
- Next day delivery available
Motel Virgo Metallic Dress
This cute retro dress by Motel is a perfect pick for adding a little casual-glam to your party wardrobe.
The straight cut gives this dress a super laid back appeal, while the side pockets play up this relaxed angle. In a futuristic silver metallic hue, this frock makes an impact on your party wardrobe this season.
Wear this metallic dress with a pair of colour pop barely there sandals, matching clutch and silver bangles.
Useful info:
- Metallic dress by Motel
- Short sleeves
- Side pockets
Motel Leah Floral Print Dress
This gorgeous day dress by Motel is a stunning piece for your lovely daytime wardrobe this season.
Covering you in pretty florals this frock works in a cute colourway of yellows and greens to brighten up your look. The scoop neckline adds a sultry appeal, while quarter sleeves keep it cute.
Wear this dress with barely there sandals and a mini tote for effortless daytime style this season.
Useful info:
- Printed dress by Motel
- All-over floral print
- Scoop neckline
- Short sleeves
Motel Amy Cut Out Back Playsuit
- In Stock
0 review
- Delivery
- Next day delivery available
Motel Playsuit with Cut-Out Back
This gorgeous playsuit by Motel is all about showing off that cute figure of your this season!
With a super nipped in style this playsuit emphasises your tiny waist, while the short shorts show off your super skinny, toned pins. Looking sleek and sophisticated to the front, this piece wows as you turn around and show off the cut-out back.
Wear this playsuit with a pair of neon barely there sandals and matching clutch for a summer-inspired colour pop.
Please note: This playsuit is an extremely neat fit and we recommend ordering a size above your usual for a look that's more comfortable and flattering.
Dressing to impress is part of the Motel girl's fashion M.O so go for your usual size for a figure-hugging fit that showcases your curves or a size up for a fit that skims your silhouette gorgeously.
Useful info:
- Playsuit by Motel
- Cut-out back
- Zip detail to back
- Capped sleeves
Motel Leigh Shirt
This Leigh shirt by Motel mixes classic touches with a contemporary shape for a look that's smart yet casual.
This shirt pulls your laid back looks together transforming them into effortlessly chic styles. With a boxy, almost cropped cut it squares your hips, while elbow-length sleeves are bang in the middle of classic smart lengths.
Wear this shirt with the floral print trousers by Motel and barely there sandals for a chic off-duty outfit this season.
Useful info:
- Leigh shirt by Motel
- Boxy shape
- Elbow-length sleeves
- Concealed button placket
- Pocket detail to front
Motel Blackbird Striped Midi Dress
- Low stock, selling fast
12 reviews
- Delivery
Motel Blackbird Midi Dress
Round neck. 3/4 sleeves. All over striped detail. Lined. Stretchy fabric for ease of fit. Approx 40 inch from shoulder to hem.
Dressing to impress is part of the Motel girl's fashion M.O so go for your usual size for a figure-hugging fit that showcases your curves or a size up for a fit that skims your silhouette gorgeously.Colour: Black. Shell: Polyester. Lining: Polyester. Hand wash cold separately. Do not bleach. Dry flat. Iron low. Do not dry clean. Do not tumble dry. Do not twist.
Motel Begonia Fluffy Knit Dress
- Low stock, selling fast
4 reviews
- Delivery
Motel Begonia Fluffy Knit Dress
Short sleeved. Round neck. Bodycon fit. Approx 32 inch long.Colour: Soft Pink. 54% polyamide, 46% acrylic. Hand wash cold. Do not bleach. Dry flat. Do not tumble dry.
Motel Lolly Swimsuit
- Low stock, selling fast
4 reviews
- Delivery
Motel Lolly Sunflower Print Swimsuit
Summer, sun and sunflowers just make sense together, so dotting them in a ditsy print all-over this swimsuit by Motel makes it the perfect pick to pack in your suitcase!
Working a little yellow into your holiday wardrobe, this swimsuit shows off your summer glow to perfection, while sunflower florals make a flirty change from standard flower prints. The delicate halter neck straps allow to you create as much lift as you want, while the cut-outs to the front and back are a sultry finish.
Wear this swimsuit with nothing other than a spritz of SPF and your favourite oversized sunnies.
Please hand wash me only to keep my floral print looking fresh.
Motel swimsuits are a super neat fit that hug your curves. For a more flattering fit, we recommend ordering a size above your usual.
Useful info:
- Swimsuit by Motel
- Sunflower print
- Halter neck straps
- Cut-out detail to back
- Small cut-out to front
Motel Amaya Flower Print Trousers
- Low stock, selling fast
7 reviews
- Delivery
Motel Amaya Floral Printed Trousers
Casual laid back trousers are the look of the season and this pair by Motel are perfect for your holiday, shopping and lunching with the girls wardrobes.
In a burgundy hue these pants channel the season's love of dark and rich palettes perfectly, while the contrast floral print adds detail and interest to your look. Their loose slim leg fit makes them super versatile, while side pockets add to their relaxed charm.
Wear these trousers with the Motel white shirt and barely there sandals for a look that says "Oh this? I just threw it on" delivering maximum impact this season.
Useful info:
- Printed cotton trousers by Motel
- All-over floral print
- Side pockets
Motel Lilah Morris Flower Jumpsuit
- Low stock, selling fast
13 reviews
- Delivery
Motel Jumpsuit with Flower Print
This floral print jumpsuit by Motel livens up the classic just in time for spring!
On a powder blue background the floral print blossoms across the fabric for a vintage inspired spring day. The leg is straight but not super skinny emphasising the cinched waist and creating a gorgeous silhouette. Quarter sleeves keep this piece transitional before we move into summer, while the zip fastening to the back of the neck perfects the fit.
Wear this jumpsuit with a pair of barely there sandals, minimal make up and a PU tote draped across your wrist for a natural beauty finish.
Please note: This jumpsuit must be hand washed only, dried flat and ironed on a low heat.
Useful info:
- Jumpsuit by Motel
- All-over flower print
- Cinched in waist
- Short sleeves
- Zip to back
Motel Flux Floral Print Bikini Set
This printed bikini by Motel is given a flirty flourish in florals adding colour and girly charm to your poolside looks this summer.
Going for a touch of fifties inspiration and mixing it with contemporary chic, this bikini features a crop top and high waist briefs giving you a little extra coverage with lashings of style. The crop is given cut-out details for a little sultry sass that's a key look in this summer's collection.
Wear this bikini under a cute Motel dress and flat sandals as you head down to the pool this season.
Please hand wash me only to keep me looking my best.
Motel swimsuits are a super neat fit that hug your curves. For a more flattering fit, we recommend ordering a size above your usual.
Useful info:
- Flux bikini by Motel
- All-over floral print
- Cut-out crop top
- High waist briefs


text:
Ammo shopping today. Reloading equipment, components also..
Evil thrives when good men do nothing!
Join us in the political kitchen to mix it up!
Discovering the Gift
Fast opinions come and go. Here are the slow facts.
Reasonable Christianity, inspiration, apologetics, and The Gospel of Jesus Christ
Christians and Patriots spreading the truth
food, stories, glimpses, life
"Strength Through Honor"
A Sovereign Opinion on the State of the Republic
He is ready to separate the chaff from the wheat with his winnowing fork
A Daily Ritual of Writing
Nothing in Life ever turns out how we expect it too and thus Life is always going to remain Undiscovered Realms..
Si vis pacem, para bellum. Molon Labe. Ita omnes pendeant tyrannis. WARNING & DISCLAIMER: All Info here is used SOLELY at the Reader's Discretion and all Readers indemnify me.
"The heart of the wise inclines to the right, but the heart of the fool to the left." Ecclesiastes 10:2
An American Church Mission in the Orthodox Faith Tradition
Second Amendment, Twenty-First Century
Institute of Theology
US Politics is personal
Your source for insights and information about Godinterest.com


text: Ocean waves are one of the most awe-inspiring natural forces. Combining energy, power, ferocity, and beauty, waves have captivated artist for centuries. The Waves collection is inspired by the wood-block paintings of Japanese artist Hokusai and by carvings on the tsubas (hand guards) of 18th century Samurai swords. The contrasting pattern of the fluid waves and the geometric sky create a compelling, textured motif.


text:
Kristen's Q & A
Favorite Sport/Team
Auburn Tigers Football
Favorite Movie/Actor
Crispin Glover
Go-to karaoke song
Touch Myself
My first job
Intern for Sports Illustrated On Campus Magazine
Piercings/Tattoos (How many? Where?)
Only a hole each ear..And no tattoos, I have virgin skin.
Mac or PC?
Nintendo, Xbox 360, PS3, or don't game?
I don't have time for that..
What fun fact, talent or superpower of yours should guys know about?
I am a professional competitive runner so I can out run most men in a 10k any day.
What's the most memorable pick up line you've ever heard?
" If hotness were spare change, I would be picking you up off the streets and stuffing you into my pants"...I use that one like ALL the time.
What's the craziest thing you've ever done?
I once swam across a glacier lake at the top Estes Park in Colorado to go on a date with a dude to Ruth Chris. I may have been borderline hypothermic but I warmed up fast when he came over and hugged me.
What's the most unusual place you've ever hooked up? How'd it go?
The grand stairway at the Arena at a New Year's Eve concert. It must have went well since we went back for seconds.
What's in your purse or pocket right now?
Just money, honey.
What do you feel most comfortable wearing?
a sheet
Would you rather have boring sex all the time or an amazing romp once a year?
I think I'm a bit to optimistic for this question, and have a high bar for my metaphysical needs, so I would only have amazing sex all the time.
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
Yoko Ono, she is such a badass!


text:
A main break sent water rushing in an area along Hurricane Road Saturday night.
There's a relatively new virus in the U.S., and it's getting a lot of notice from researchers at the Centers for Disease Control and Prevention (CDC).
According to the CDC, norovirus causes your stomach and intestines to become inflamed, giving you stomach pain, nausea, diarrhea, and vomiting. This can, in turn, lead to dehydration and, possibly, the need for hospitalization. In fact, each year, noroviruses cause about 70,000 hospitalizations and 800 deaths, mostly in young children and the elderly, according to Dr. Aron Hall, an epidemiologist at the CDC specializing in norovirus.
A new strain of norovirus is called GII.4 Sydney norovirus; it was identified in March 2012 in Australia. It is especially easily spread, as the majority of Americans don't yet have an immunity to it, and it takes fewer particles of this virus to make you very sick. According to ABC medical contributor Dr. Richard Besser, it takes 1,000 particles of flu virus to make a person sick; however, it only takes 18 particles of the Sydney strain of norovirus to infect a person. Besser also said that this strain can cause you to become ill within just a few hours of exposure, leading researchers and doctors to nickname it the "Ferrari of viruses."
In the U.S, it is now accounting for about 60 percent of all norovirus outbreaks, according to the CDC. As with most viruses, it is most severe in older adults and children, and others with compromised immune systems.
The Sydney strain of norovirus is like other viruses in that it can be spread via food that is not cooked properly or that is handled by an infected person, as well as by physical contact with a surface touched by an infected person who did not wash his hands well enough or at all. However, the CDC says that the newer Sydney strain can also be spread through the air by droplets sprayed when a sick person vomits. The droplets carries particles that can cause illness for several hours.
Since it is a quick-spreading virus, in close quarters like daycare centers, nursing homes, restaurants, malls or schools, it can spread from person to person quickly through the air, by touching a person's hand, touching a surface that was touched by an infected person's hand (even hours after he touched that surface), eating food prepared by someone with the virus or drinking from the cup of someone who has the virus.
It is important to note that the CDC says that hand sanitizers are not enough to kill the Sydney strain of norovirus. It appears to need the friction of thorough handwashing with soap and water, then rinsing the virus off with the water, to be removed. This does not occur with hand sanitizer.
It is also important to note that you can still spread the virus up to three days after you feel well again, according to the CDC website.
The CDC offers the following tips to help prevent and control the spread of norovirus:
Follow these procedures carefully to avoid getting the virus or to avoid spreading the virus after it has been contracted. If you do feel that you are sick, call your doctor or health clinic immediately, drink plenty of fluids, and get as much rest as possible.
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text:
Ashley's Q & A
Who's your favorite sports team, and why?
I have to rep New England and go with the Patriots.
What's your favorite movie quote?
"I'm pretty sure there's a lot more to life than being really, really, ridiculously good looking. And I plan on finding out what that is." Zoolander
What's your favorite video game, and could you kick our butts at it?
One game that I am really good at is Mario Kart and I would definitely run you guys off the road.
Piercings/Tattoos (How many? Where?)
I have my belly pierced.
What's the most embarrassing song on your iPod?
Becky smdh I know I know....but I love that song....hahahahaha
What's your best party trick?
Well my aunt says I dance like a stripper.lol
What's the most memorable pick-up line you've ever heard?
Excuse me miss, you must be a ticket because you fine!
What's the worst job you've ever had?
The worst job I ever had was working in my college campus cafe. They made us wear this ugly purple snapback.
What's the most dangerous thing you've ever done?
I went parasailing in the Bermuda triangle
It's 4AM after a crazy night out – what are we eating?
Dark Salted Chocolate with Almonds! Yum!
What's the strangest thing in your fridge right now?
3 different types of hot sauce. I love hot sauce! Mild, Hot, and Nuclear.
What's the naughtiest thing you've ever done in public?
I would have to let my ex answer that question.
What do you feel sexiest wearing?
I feel most sexiest in my birthday suit and it's not even my birthday!
Tell us a joke.
Two nuts were walking down the road, one was a salted.


text:
Search Results: "54213"
Unfortunately we don't appear to have any products that match your search criteria. Some of our more popular searches are shown below:
Dear all I don't usually make a habit of emailing companies after I have received goods that I have ordered BUT on this occasion I am. This is because I would like to say "thank you" not only for the well packed and promptly delivered dog beds I ordered but because the quality of the said dog beds is outstanding! AND better still they were half price! Just wanted to give you a big thanks from me!
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Wedding Caterers near erickson,bc
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Cocktails and Canapes Catering + Events1 Review
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Say goodbye to rubber chicken dinners! Your guests arrive; anticipation of the celebration is building. They indulge in fine foods, scintillating...(more)
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This is the Cocktails & Canapes experience: Get Three Delicious Courses for your Wedding and save $5 off our menu price! Choose 3 Canape Options. Choose 2 First Course Options. Choose 2 Second Course Options. Get the Dessert Trio for your Third Course. What This Offer Includes: 3 Courses + Canapes. Service Staff. Tax & 18% Gratuity NOT included. Can not be combined with any other offer or promotion. Cancel anytime within 30 days.
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text:
Poem written by G. Pocock
To view other similar items in the archive click on the hyper-linked words below.
|Pockock, G.
|Poem written by G. Pocock
|My late father and his four brtohers all went through the first world war, my father being recruited from Landguard fort, Suffolk, and sent to Scotland. He was in dugouts under the Forth rail bridge on the Leith (south) side of the river. There he took turns in manning the guns, one on Inchcolm, one on Inchkeith, and one on Inchmickery, and had to take turns in driving out to each island with supplies for the men. He wrote this poem during he service in Inchkeith. Afterwards, he was sent to Africa, being stationed in Freetown in the Orange Free State. He was later invalided back to England and spent some time in the spa waters of Bath, which were a daily routine until his joints were working again. He was later sent to Gorleston-on-Sea, Norfolk, and had lodgings in Springfield Road and 2, Victoria Road. He took turns in manning the anti-aircraft gun on the cliffes at Gorleston seafront, and was on duty the morning the Armistice was signed. The gun was sited on what is now a patch of grass in front of the Gables nursing home.
Editor's Comment:
Poem written by Gunner Pocock while stationed in the Firth of Fourth forts, defending the naval habour of Rosyth. Transcribed by his daughter, Miss Jean Pocock.
Gunner G. Pocock served for a time in No. 1 Coy., Essex and Suffolk (Territorial Force) Royal Garrison Artillery, when stationed in Landguard Fort, Harwich.
|Item Date
|1914 - 1918
|Creation place
|File type
|Item source
|Item medium
|Richard Marshall
|The Great War Archive, University of Oxford / Primary Contributor
|Digital repository
|The Great War Archive, University of Oxford
|Contributor Name
|Richard Marshall (Norwich and Norfolk Millennium Library Submission Day 8th April 2008)
|Contributed on the behalf of
|Miss Jean Pocock
|Reference URL


text:
Mass Effect 3 Listed on EA Store, Quickly YankedAlthough we knew it was in the works, it appears that someone at the EA Store was unable to contain their excitement as Mass Effect 3 has appeared on the site earlier today.
Listed for the PC, Xbox 360, and PS3, Mass Effect 3 will continue the planet-hopping adventures of Commander Shepard and his (or her) ragtag crew of helpful heroes--or maniacal miscreants, depending on your choices.
A brief description of the third adventure from EA's listing can be found after the break. Warning: if you don't want to know anything about the next installment, you should avoid the description.
No release information was added to the listing. The appearance of the game on the site--with platforms and price revealed--is perhaps placeholder data, but it's heavily rumored that this is the game BioWare is set to reveal during the 2010 Spike VGAs. It is also rumored to include multiplayer.
The listing offered the following summary for the adventure (warning, could contain spoilers):
Earth is burning. Striking from beyond known space, a race of terrifying machines have begun their destruction of the human race. As Commander Shepard, an Alliance Marine, your only hope for saving mankind is to rally the civilizations of the galaxy and launch one final mission to take back the Earth.
Since this post was put in our editorial hopper, ready to go live, EA has pulled the listing. Thankfully, we've captured a screenshot of the PC version's game page. Now, the above link redirects to a page with a game title listed as: TBD (to be determined). We're determined to play some more Mass Effect, so EA might as well just hurry up and tell us it's already happening. They've already been talking about it anyway, you know.
[Thanks for the tip, Jeff]
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text:
Vic Steamboat (ICW)
Ricky Landell
King Kaluha - OWW
Upcoming Indy Wrestling Events August 30 - September 7, 2014. This listing is sent weekly by Nate Stein.
Squandering A Mega Star: The WWE Blew It With Ryback
Wahoo McDaniel vs. NWA champion Ric Flair
Does WWE have a legends problem?
Nick Bockwinkel steps down as CAC president
Nicole Matthews is looking to end Cheerleader Melissa's SHIMMER reign early, will she be successful?
Upcoming events August 30 – September 7, 2014
Copyright © 2014 Black Pants, Inc.


text:
May 24, 2013 by Editor
May 24, 2013 by Editor
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text:
Monday, December 12, 2011
Project Life Week 31
This is another big week with lots of extra pages. Me and the kids were in Utah for our family reunion. Also I took the kids in for a photo shoot. I had won a free photo shoot and hadn't had time to use it before we moved out of state.
The first page.
The pictures from the first page Our view from the back deck at the condo. At the family reunion.
Maddie and Katelyn on the dock at the lake
The girls and I on my parents waverunners. The brush is from Ali Edwards Summer rocks set.
The journaling cards. Letter stickers from October Afternoon. Talking about the condo we stayed in.
Relatives is from Ali Edwards family words set. Just a few things that I wanted to remember from the reunion.
This is the card featured in the tutorial. Circle tag and yellow tag from Jillibean soup.
I have three extra pages this week. The first one is an 8x8 page from the kids photo shoot. Love these 3. Sorry for the bad pictures. The sun was setting, I guess I should have waited till tomorrow.
The other side.
Here are some close ups of the pictures from the photo shoot.
Here are some more pictures from the photo shoot. I used the design G from Becky Higgins page protector and I am convinced they are going to be my favorite.
The other side was filled with extra pictures I had from our reunion.
Close ups
I added in a 6x12 divided page protector for some more pictures from our reunion at the lake.
Close ups
The other side
Close ups
Brush from Ali Edwards go outside set
The last page. Katelyn swimming. Playgroup. Tomatoes. Water fight.
The word play if from Ali Edwards playing handdrawn words set.
The brush is from Ali Edwards summer rock set.
The journaling cards
Can't remember where this card came from but the happy circle is from the Turquoise extra digital elements.
This is the card featured in the first tutorial.
Also another card featured in the tutorial.
Kraft tag from Maya Road. Butterfly and circle from Jillibean soup.
So that was week 31 August 1-August 7. I have a lot to catch up on I know. But I will get there. How is your album coming along ?
Has anyone been printing on their journaling cards ? Hope everything is well and you all have a great Christmas.
12 comments:
- thoughtsalonglifeshighway.com said...
Those are beautiful pages and inspire me to do a little more with my PL project next year! LOVE them.
- December 12, 2011 at 12:09 PM
- LauraLee said...
Thanks for sharing again! I am getting really excited about starting my project life! Just have the page protectors to get and then I am set!! ....On my bigger wish list is a typewriter.
- December 12, 2011 at 12:27 PM
I love the idea of printing on the journaling cards!!! Any suggestions or tricks of ways you did that, thru the printer?
Love your layouts!!
- December 12, 2011 at 1:09 PM
Just saw your tutorials on printing on the journaling cards! So I just posted the above comment, so my question is answered :) Thanks for posting the directions!!
- December 12, 2011 at 1:13 PM
Great spread as usual! I was wondering what version of photoshop elements you have? I don't currently have any and was wondering which you suggest? There are so many on Amazon and I'm hoping for one for Christmas:) I just love the look of printed journaling cards and hope to do that with my project life next year as well as using some other digital elements.
- December 12, 2011 at 2:05 PM
- Mindi said...
Thanks so much for all your wonderful comments.
Eileen - I don't know much about the different versions of photoshop. I have photoshop elements 8 and does more than enough stuff. I don't even know half of the things it can do. Sorry I couldn't be more help to you. But I would just buy Photoshop Elements 10. I think that is the latest version.
Merry Christmas everyone.
- December 12, 2011 at 2:15 PM
- jengaither said...
Thank you so much! I will be stealing your ideas for my project life! How do you write on your photos? Like when you wrote "learning the virginia reel" or the line about the cousins? Thanks!
- December 12, 2011 at 3:54 PM
- Jenny Meyerson said...
Absolute gorgeous photography. Just learning to add digital elements to my December Daily journal. I think I need to branch them out to my pictures this next year. Gorgeous, gorgeous work.
- December 12, 2011 at 4:05 PM
You once again did a great job. Your PL is one of my favorites. Thanks for posting.
- December 12, 2011 at 4:28 PM
- Mindi said...
Jengaither - Thank you for your comments. All my writing and digital stuff is done in photoshop.
- December 12, 2011 at 8:38 PM
- Marcia said...
How do you print on your photo? Do you do this before printing it at home? Or can you add this to a photo that is already printed? I haven't ventured out in this way yet. Thanks. Your pages look great.
- December 15, 2011 at 11:15 AM
- Mindi said...
Marcia - I journal (write) on my photos using photoshop and then print them here at home.
- December 15, 2011 at 1:25 PM


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Ok. I am keeping this light and trying to make it work. It has pros and cons. Let me tell you the truth and you can decide if this is the light for you. WHAT IS THIS LIGHT MADE OF? This light is not ALL iron. The orb is. The chandelier parts are steel or tube metal or something. The light comes almost fully assembled. WHAT ABOUT THE CYRSTALS? The crystals are pretty, have a few with scratches, bubbles or other defects but are still pretty. I have plenty left over crystals to choose the best ones since you have one terrible diagram to look at to try to figure out placement of all the crystals. Still not a terriblle situation- I used my creative license and the crystal set up looks really good (and I have plenty of left overs for replacements). The attachments between crystals are the gold color. WHAT IS THE COLOR OF THIS LIGHT? Ok- this is where I am pretty disgusted. The light claimes it is "iron". I (wrongly) assumed an iron finish meant black wrought iron. Maybe it was a little rusty (that would have been great!). But no. The paint is a glossy black paint with glossy bright red speckles. Even the "candles". It is so tacky, so dollar store, so so ugly. (PS I love dollar stores too, so no offense). I tried my best to fix this situation by buying spray paint in rust color and textured. Sprayed the whole light. Only problem is the one glass piece on the light isn't removable. I can see through the glass and notice the horror show paint behind it. I am hoping it isn't too noticable to anyone else. Time will tell if this is a livable situation. OTHERWISE, now that it is a rusty looking light, it looks great, very very basically exact to a light on my favorite "restoration" site. That light cost over $2000.! So this is quite a savings (as long as the terrible original paint doesn't show through the glass). It's a mixed bag- good deal if you want to do the work and you compare the price to that other site, but 250 bucks is an aweful lot of money to spend on a light that you have to fix to make pretty
there is a lot of assembly, but it was worth it for the price. the crystals aren't actual crystal and the little hooks that hold them in place seem flimsy, but they hold fine and you can't tell when it's up in the ceiling space. there are a TON of extra parts, and the instructions could be better, I just went by the picture and made up some of the design.
I love the style of this chandelier BUT I was hoping I would have the option to keep the crystals off for a more rustic look. I knew they required some assembly so I figured if I left them off, it would have the look I was going for. Well, the crystals themselves are detachable, but the crystal/glass collar at the top of the fixture is not... nor are the small crystal buttons on the ends of the chandelier arms. I was so bummed- I really wanted to love this fixture but I returned it without even hanging it. If you like the crystal look, this chandelier is a great option for the price point!!!!!
I drooled over this light for months before I bought it. It kept going in and out of stock. When I would go to buy it, it would be sold out again! Finally I was able to buy it with only four remaining! This light shipped extremely fast and came in very big, well packaged box. I guess I didn't read the dimensions closely because the size of the light surprised me a bit. It was bigger than I expected, but still worked well. You might want to get a tape measure out and double check! : ) I have nine foot ceilings and we just shortened the chain so it looked good in our sitting room. This light is in a room right off my entry way and it gets a lot of attention. The light is bronze with very small reddish flecks. I didn't think it distracted from the beauty. Once its up, its a stunner! The crystals are attached with gold clips. I love gold and bronze, so this worked well for what I had planned. I am very happy with this light and the price. I can't afford the original designer one at almost ten times the price, so this is a great substitute!
I was drawn to this light immediately due to the unique design for my entry foyer. The iron is strong, but not super heavy. Color of the light is closer to black than antique bronze. Beware that there is a lot of assembly with the crystals and there are confusing directions on how to string the crystals. In the end, I winged it and used my own design. The crystals are NOT Swarworski and the wire holding crystals together is gold and pretty flimsy, but when the light is hanging is it beautiful and no one is the wiser. Many. many compliments and 90% cheaper than the original "Foucault's orb" at a major design retailer. Great job again Overstock!
As other reviewers have mentioned, the color is strange. It was a black finish with red splotches all over it. I needed an oil rubbed bronze fixture for our kitchen, so I taped off all the glass, hung it from a tree, and spray painted the entire thing ORB. The instructions are not great, so you'll need to use the photo and a little of your own creativity to come up with a design that you like. In spite of the extra work to make it exactly the color I needed, I have to say that it's a large fixture for the money, the crystals sparkle nicely, and they give you a decent amount of extra crystals. Overall, a lot less money than it's famous high end counterpart, and not bad looking to boot.
This light is an extremely good value compared to the original light at RH, which is more than six times the price of this one. No - this light is not the same quality as the real version, but it's good enough - and once hung, no one will be able to tell it's a lesser quality copy. The color is, as others have pointed out is black with red/rust colored metallic paint splotches. Looking up close, it looks really cheap - but from a distance, it looks more like iron. The crystals are not real crystal - I'm not 100% sure if they are glass or plastic, and a few of them were broken - but they did provide extra crystals. Again, once hung, the light looks very very good, and not cheap at all (but up close, you can tell the quality isn't the greatest). The added bonus of this light compared to the real one, is that it is much lighter in weight, which made it easier to hang. Depending on how high your ceilings are, you may need a longer chain and cord. We were hanging this in a vaulted spaces (2 floors high), so the chain was way too short (we needed about 6 ft of chain, instead of the shorter chain that was provided). Also, there are really no real directions on how to hang the crystals - just print out a copy of the light pictured online, and use that as a guide to figure it out. I'm really happy with this light. It was a pain to assemble, but well worth it to have the look of a RH chandelier at a fraction of the cost. From the ground it looks wonderful!
So pretty! What a great value for the price! We looked at others that were anywhere from $500 to $1000 and were so happy with the overall product for what we paid. The finish is actually black with burnt red metallic flecks. It is actually a little larger than we imagined as well, but looks absolutely stunning when hung and lit.
Looks like something from restoration hardware for a fraction of the price. Great for an office, entryway, living room, or smaller dining room.
This chandelier is stunning over my dining table. Everyone who walks in asks if it's from that really expensive retailers that makes the original version of this light. Look - As pictured. The metal is painted black with tiny red speckles. From a distance you don't notice them, but it gives the metal some dimension. Assembly - I have no idea if my crystals are arranged correctly. The diagram and the online photo provide no detail...so I winged it. I'm happy with how it turned out. Size - Perfect above a rectangular rustic dining table. I did not make any adjustments to the chain length. Quality - Seems pretty excellent. The crystals are glass, not plastic. The frame is sturdy. I would have liked better assembly instructions, but otherwise the quality it great.
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The Putnam County Fair is a month away. Flyer attached but registration will be August 2nd. I have taken charge of the Boy Scout booth at the fair for the past 15 years. This will …Read the full story »
Our MT-61 Wood Badge Course to be held 1st weekend September 5-7 and 2nd Weekend September 26-28th. 27 Participants are signed up and NONE are from the Upper Cumberland.We can do better than this! If …
Boy Scout troop 234
And Mr. and Mrs. Rodgers
Cordially Invite You to Attend Eagle Scout Court of Honor
Alex Rodgers
Saturday April 26th 2014 7:00 PM
Peachtree Learning Center
402 N Walnut Ave, Cookeville, TN 38501
Dear Scouting Friend,
We need your help!
Scouting costs money to keep going. You probably already know that your registration fees go straight to National, and that the modest fees we charge for summer/winter camp don't even …
Your unit should be 100% Youth Protection Trained they are not!
Come to this training opportunity and we will have access to 30 computers to take care of Youth protection and Committee basic training. Other training …
Here is a neat event going on up in Celina July 10th. Sounds like a great outdoor activity that can help you continue your program through the summer months and also help you earn …
The District webelos crossover
Will be April 12 @ 2pm at Walnut park. If your webelos are attending the cross over please let me know how many boys will be crossing over and what troop they are …
The Upper Cumberland District Banquet is Tuesday March 18 2014 at Collegeside Church of Christ 6:30 PM
The Upper Cumberland District Banquet is March 18 2014
Collegeside Church of Christ CLC room
252 E 9th St Cookeville, TN
6:30 pm Cost $14.00 …
Nashville International Airport, TN
Last Updated on Oct 2 2014, 7:53 am CDT
Weather by NOAA
Current Conditions: Mostly Cloudy
Temp: 68°F
Wind: South at 5mph
Humidity: 78%
Dewpoint: 61.0°F


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Rated 4.2 out of 5Â by 167 reviewers.
Men's adidas Swim Shoes
adissage Slides
New Navy/New Navy (078261)
Size Chart
+ Save To Wishlist
Rated 2 out of 5Â by Jonc not sure about these yet I like the look and the size is right on for my feet, width is perfect. Everyone says they are painful to wear because the nubs, they are right, these things, if you wear them barefoot will kill your feet, alot of people say they wear socks with them, I was under the impression that that was a total fashion no-no, wearing socks with sandals is supposedly horrible, but its the only way to wear these for sure, the material that the nubs is made of is way too stiff, after an hour barefoot in them i took them off and went barefoot for real to ease the pain. Too bad because they are the best looking slides they make in my opinion. June 19, 2012
Rated 5 out of 5 All Day i Dream About Sports.. Adidas adidas are by far the best slides you can buy. the nike slides will rip after time, and slip off your feet. Adidas slides are tight, comfortable and will very much message your feet :) . i wear them after soccer games when my feet are just killing me. (i play diffrent clubs all the time so i am always playing soccer). And within fifteen-twenty minutes my feet feel amazing! i have had mine for about a year and they still look great. You can honostly wear them anywhere and they look GREAT WITH ANY OUTFIT. i hope my review will help you buy them if you are still second guessing them. If i ever make it to premier league. i will be advertising these for sure. December 21, 2012
Rated 5 out of 5Â by kamikazmik May Take Time Received a pair many years ago as a gift. At first, they stung my feet like no other! But i was determined to wear these since the gift was from a dear loved one... after a week or two they increasingly felt better until they felt GREAT! Wearing basic sandals won't cut it anymore. I continue to buy these exclusively and wear them often! If your feet hurt at first, that means they are working! The bottom of your feet are in worse shape than you thought! They NEED to be constantly massaged! Keep wearing them and soon they will feel amazing, take my word for it! A++ 5-STAR Sandals! July 13, 2011
Rated 5 out of 5Â by ADi daAhs Feet Feel Fantastique! I'm not a doctor but I have Plantar Fasciitis and it has wreaked havoc on my productivity and overall health because I didn't feel like doing much of anything which involved mobility except for what I had to do, like work. These slides have helped my feet tremendously on the road to recovery, they hurt at first but after a few days your feet will become completely satisfied wearing them. Sandals, especially flip-flops are terrible for ailing feet but these are a different animal, I wouldn't suggest somebody wear them all over but they're great for little trip to the store or a house shoe. Get 'em, you'll love 'em! September 16, 2011
Rated 4 out of 5Â by Nou :) Must have I originally bought these shoes because I noticed that everyone had them and I like to stay on top of trends. It turns out that these shoes aren't only fashionable and popular, but they are extremely comfortable. In terms of size, they seemed to fit just fine. I am very happy with my decision to buy these. The frills are very soothing, especially when you are standing for a while...a lot of people complain about how it hurts and it's uncomfortable, but honestly, like any new pair of shoes you just have to grow into them. I wear them around my dorm room, sometimes I take it outside and I also use them as shower shoes. I love how they literally take the shape of your foot...definitely the best pair of slippers I've bought. December 11, 2010
Rated 5 out of 5Â by Railroader The best sandals I've purchased. You guys out did yourselves. By far the best footwear that I have purchased. Can't say enough of these sandals. My feet feel great after wearing these sandals. Thanks people. I'm thinking of buying a second pair. September 19, 2011
Rated 5 out of 5Â by honey girl AMAZING!! I have had my Adidas Slides for two years now! they are by far my favorite shoes I have ever owned. I wear them shopping, to school, after sports practices, all the time. Everyone is say you're supposed to wear them without socks, but I have always worn mine with them. I honestly don't think they look awful with socks, especially since everyone I know wears Slides with them. I wear these 5+ days a week, so they've had rough wear. They have just began to tear towards the top, again, I've had them two years, and some of the little nubs are falling off, but considering how often I wear them, and that I am out-growing them, it isn't awful. I would never hesitate to buy these shoes. March 30, 2014
Rated 4 out of 5Â by marksr Adissage First time I put these on they hurt my feet . Now I want them on all the time. A quick shake and the beds are dry these are great shower shoes at a great price May 8, 2011
Rated 1 out of 5Â by Yeti Great for a month... I got these about 40 days ago, after the first week the nubs got soft enough to wear in long durations. The problm i have and why i gave these a poor rating is because the left foot, 70% of the nubs have come off. I can probably shake the shoe and watch the other 30% of them come off. The right foot is fine, all the nubs are still intact. For 30 bucks id rather pay to get punched in the junk. I have purchased Addidas products from shoes, jumpers, shirts, jackets, hats for almost 20 years and these are no where near the quality the Addidas brand is, or was? August 10, 2012
Rated 5 out of 5Â by pachi adidas there just great to me,my dad and mom always told me its the way to go.what i think is that im always feeling great and cumfy.they last a while but i like to say they look good. fabric is awesome and i recommend them. if you have some money spend it on adidas.you'll feel excited.im likeing them right now typing this review. January 5, 2014


text:
Hi Mom with Preemies
I was talking to bunch of moms in one of my moms group and we figured out something that we have in common, that we live with cats. I wonder how many of you have cats and had preemies while caring for cats?
I know that kitty litter is supposed to be bad in general for pregnant women, but has anybody heard if it causes prematurity? And now that I am pregnant, DH has taken over that part.
Don't get me wrong, I love my two animals and would never consider giving them up, but there were a lot of similarities with other moms and having preemies. We were just curious if this topic has been talked about before?
Deborah 35
Natan almost 3 years(preeclampsia baby)
{Peeps 14yrs}
{Phreddie 4yrs}


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Style: Wavy
Material: Synthetic
Length: Mid-Length
Hair Length: 5".
Weight: 4 oz.
Length: Mid-LengthHair Length: 5".
There are several ways to contact us:
Phone: 1-800-689-2587
Fax: 1-508-238-1965
Email: email@example.com
(based on 23 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Most Liked Positive Review
Don't judge a book by it's cover!
I immediately throw away the headbands!! In my situation, my hair is extremely fine and thinning in the front. This piece has two combs attached, one in the front and one in...Read complete review
I immediately throw away the headbands!! In my situation, my hair is extremely fine and thinning in the front. This piece has two combs attached, one in the front and one in the bottom back. I gather some of my hair in the front into a pincurl and twist the back with a clip. I attach the front comb to the pincurl and wear a wide cloth headband that covers the velcro on hairpiece and comes down a bit on my forehead for a great look and overall coverage. I LOVE THIS PIECE AND HAVE SEVERAL!!!!
Most Liked Negative Review
too tight, too curly
This was just too curly for my taste. I thought it could be styled a bit "looser" but (not). I also thought I might be able to pull my own...Read complete review
This was just too curly for my taste. I thought it could be styled a bit "looser" but (not). I also thought I might be able to pull my own hair over the piece and then place the headband so the color would blend. This wasn't possible because of the velcro. Can't say I wouldn't recommend this for someone that prefers the curly look. It just was not a good look for me. Returned the product. I think P.Y. should have more alternate views of all hairpieces and maybe a bit more info on descriptions.
Reviewed by 23 customers
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(2 of 3 customers found this review helpful)
Beautiful and natural
By Jennifer
from Indiana
Comments about Wispy Waves Changeable Headbands by Paula Young®:
I was diagnosed with Alopecia and have now lost 60% of my hair. I was feeling terrible about the way I looked, trying to fill in all the holes. Decided to try this and see if it would help. I just wish I would have ordered it sooner! I've had so many compliments on it, great color match and looks natural. I feel so much better! Hopefully my hair grows back but if not I have options!
Bottom Line Yes, I would recommend this to a friend
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(3 of 4 customers found this review helpful)
Fun & quirky
By Louise
from Michigan
About Me Beauty Conscious
I have looking at this often & was disappointed to discover it does not fit well over hair that is short in the back. I'm really bummed because I expected to have a different look every day with the headbands you can switch out. I have returned it & am awaiting a replacement, hoping for the best.
(9 of 9 customers found this review helpful)
By Just me
from Massachusetts
About Me Minimalist
(1 of 1 customers found this review helpful)
best wig ever
By qtowngirl
from Phila pa
Love this...looks amazing
My Miracle Hair!!!
By HONORABLE GOOD MOTHER
from Wilmington, Delaware
This is my main go to style. No one knows that its not mine. Its just like my own hair, the difference is that this piece is always dependable. I wear it for casual and dressy. It's perfect!
(12 of 12 customers found this review helpful)
Perfect Hair
By Tuesday
from Brook Park, OH
Wear it for work, much less time than styling my own. Looks natural, everyone (including a beautician) thinks it is my own hair.The only change I would make is to maybe give the band a little padding by the ears. It is a little bit hard.
Adorable & lots of compliments
By HMJRN
from Tampa, Florida
I am an RN in a busy Nicu and wore this to work and received numerous positive results from my co-workers. The color was a perfect match to my hair so I simply left my bangs out and everyone was surprised it was a wig/hairpiece. The band and the 2 combs keep it snug on your head even with all the bending and head turning that I do in a 12 hour shift. Actually, almost too snug as I had to glue a small piece of sponge on the ends of hairband to make it more comfortable.The service was excellent as usual.
You can fix the headbands.
By DannyJane
from Houston, Tx
The headbands are nearly perfect circles, which means they are too tight for most heads. You can fix this with your flatiron. Turn it to its highest heat and run it over the plastic until the plastic softens. It can then be reshaped to suit you. Remember the plastic will be hot so you have to wait for it to cool slightly, but you can do this over and over until you get what you like. Or you can throw the plastic headbands out and buy/make cloth ones. Remember to use the kind that have elastic on the back. They work best. The wiglet is wonderful, comfortable and looks great on. The hair match is nearly perfect.
Great Wiglet--Terrible Headband
The wiglet itself is very nice although much curlier than the photo.The headband is badly shaped. It's much too round for a human head and digs in over the ears. However, there's a fix for the problem. Take your flatiron, set it to the highest temperature and run it over the headband until the plastic softens. Then reshape it until it fits. I also use cloth headbands. I recommend they be at least 2" wide and are sewn onto narrow pieces of elastic.
Like it but...
from Texas
I used to wear wigs and hairpieces in the 60s and 70s but I started dying my hair a lighter color and could never find hairpieces to match. Now that I'm going darker I wanted to have them again. This demiwig is very comfortable to wear. I advise you to toss the headbands which were apparently sized and shaped to fit a softball. Buy yourself some pretty scarves and stretch bands. The wiglet becomes a lot more flexible and comfortable. I love that there are two colors that vanish into my own. The wave can be brushed or allowed to become a riot of curls. My waist-length hair disappears under and suddenly I have short, bouncy looks that are cute and easy to do. Please, Paula, make more demiwigs.


text:
Kim's Q & A
Who's your favorite sports team, and why?
My favorite sports team is the NY Yankees! because I am loyal to my city and the Yankees are the best baby!
What's your favorite movie quote?
"Gentlemen you had my curiosity. But now you have my attention" Django Unchained
What's your favorite video game, and could you kick our butts at it?
My favorite video game is the WWF bras and panties wrestling match for play station 2. SUPER OLD! I can kick anyone's butt at it.
Piercings/Tattoos (How many? Where?)
3 tattoos one on my left forearm, right hand and chest. Also have 3 piercings, belly ring and ears.
What's the most embarrassing song on your iPod?
Aqua- Barbie Girl aha gotta love it!
What's your best party trick?
I really don't party much however I am pretty amazing at dance offs!
What's the most memorable pick-up line you've ever heard?
"Do you believe in love at first sight? or should I walk by again?"
What's the worst job you've ever had?
Catering a wedding, cleaning up after people definitely isn't my thing! it was incredibly gross.
What's the most dangerous thing you've ever done?
Definitely sneaking into a pool when it was closed and getting chased by the cops in my underwear when I was 17. I was such a dare devil.
It's 4AM after a crazy night out – what are we eating?
Spanish food at Empanada Mama in hells kitchen!
What's the strangest thing in your fridge right now?
uh batteries? aha makes them last longer.. I think..
What's the naughtiest thing you've ever done in public?
I can't say =X
What do you feel sexiest wearing?
I feel the sexiest in my pink silk robe.
Tell us a joke.
Yo mama is so stupid that she tried to call Dr pepper to discuss her health concerns. hahaa!


text:
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Ray-Ban RX7016 Prescription Progressive Eyeglasses with custom-made no-line progressive lenses are distinct for trend-setting styling that is available only from the world's best-known eyewear brand. As an authorized dealer of Ray Ban Rx Prescription Optical Glasses, and as the leading online retailer of Prescription Eyeglasses and Prescription Designer Sunglasses, OpticsPlanet is proud to offer genuine Ray Ban RX7016 with no line multifocal lenses at our lowest sale price, and Free Shipping is Included!
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Construction of Presidio Parkway is moving full speed ahead! Much of the work can be seen from the Presidio and Doyle Drive, including the new High Viaduct, three new tunnels, and now the low viaducts rising out of the ground at the East End. Check out the June Construction Update and our latest additions to the photo gallery.
A new temporary alignment is in place at the Highway 1/101 interchange. View the simulation video and Look Ahead slideshow for details. (Photo: Karl Nielsen/MTC)
Select features and icons on the map to explore areas under construction, Webcams and current construction advisories.