text: Narcotics Anonymous Website Updates Daily updates from the NA World Services website http://www.na.org/rss 2014-09-30T23:02:35+01:00 Narcotics Anonymous Website http://na.org/ http://na.org/images/logo.jpg text/html 2014-09-25T15:00:00+01:00 http://www.na.org/?ID=wcna-index World Convention of Narcotics Anonymous http://www.na.org/?ID=wcna-index WCNA 36 - June 11-14, 2015 - The Gift is Freedom We understand that many of you are planning to attend WCNA 36 and are waiting for more information to help you with those plans. We have not yet been a text/html 2014-09-23T15:00:00+01:00 http://www.na.org/?ID=NAMeetings-WhatHappensAtAnNAMeeting What happens at an NA Meeting http://www.na.org/?ID=NAMeetings-WhatHappensAtAnNAMeeting "If youâre new to NA or planning to go to a Narcotics Anonymous meeting for the first time, it might be nice to know a little bit about what happens in our meetings. The information here is meant to give text/html 2014-09-19T15:00:00+01:00 http://www.na.org/?ID=naway-current The NA Way Magazine Current Issue http://www.na.org/?ID=naway-current The NA Way Home PageThe NA Way ArchivesSubscribe to The NA WaySubmission GuidelinesSuggested TopicsAuthor Release FormJuly 2014 EnglishFrenchGermanSpanishPortugueseRussianJapaneseAs of the March 2010 the onlin text/html 2014-09-19T15:00:00+01:00 http://www.na.org/?ID=reaching-out-index Welcome to Reaching Out http://www.na.org/?ID=reaching-out-index Welcome to Reaching Out! Whether you are an NA member, a professional who works with recovering addicts, an incarcerated member or a member who provides Hospital and Institution service, this NA Wor text/html 2014-09-12T15:00:00+01:00 http://www.na.org/?ID=legal-bulletins-fipt Fellowship Intellectual Property http://www.na.org/?ID=legal-bulletins-fipt Fellowship Intellectual Property Trust and Related Bulletins September 2014 Bulletin about NA Copyrights and Literature FIPT Bulletin No. 1 (Revised) Internal Use of NA Intellectual Prope text/html 2014-09-12T15:00:00+01:00 http://www.na.org/?ID=reports-nawsnews-nawsmain NA World Services News http://www.na.org/?ID=reports-nawsnews-nawsmain Welcome to the online home of the NA World Services News. You will find all issues of the news since the last meeting of the World Service Conference. The News is translated into French, German text/html 2014-09-02T15:00:00+01:00 http://www.na.org/?ID=catalog-products Products http://www.na.org/?ID=catalog-products We post our catalog and order forms as PDF's. 2014 NAWS Product Catalog Product Updates June 2014 November 2013 August 2013 March 2013 | European Version Order Forms 2014 NAWS Order F text/html 2014-09-02T15:00:00+01:00 http://www.na.org/?ID=conference-index World Service Conference http://www.na.org/?ID=conference-index <img border="0" alt="" width="250" height="284" (This page will be updated periodically as more information becomes available.) Post WSC 2014 WSC 2014 Draft Summary of Decisions Pre W text/html 2014-09-02T15:00:00+01:00 http://www.na.org/?ID=trads_project Traditions Book Project http://www.na.org/?ID=trads_project .auto-style2 { border-width: 0; } Project Background WSC 2010 adopted a motion to create a project plan for a Twelve Traditions working guide, and a 2011 fellowshipwide literature surv


text: The age old kitty debate...SOLVED! (kind of) Wednesday, October 16, 2013 6:07 a.m. by Justin Should you keep your cat inside and safe, or let them wander your neighborhood enjoying nature, which can be perilous but fun. This video lays out the arguments for both, pros and cons and even gets the opinion of our feline friends. By Martin Bahmann (Own work ( Deutsch: fotografiert 2004 )) [GFDL (http://www.gnu.org/copyleft/fdl.html) or CC-BY-SA-3.0 (http://creativecommons.org/licenses/by-sa/3.0/)], via Wikimedia Commons

subset: commoncrawl


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Aliens vs. Predator Trailer Remembers Aliens versus PredatorThe Rebellion gang wax lyrical about their seminal 1999 PC shooter Aliens versus Predator in this new trailer for their 2010 PC, Xbox 360 and PlayStation 3 inter-species rumble Aliens vs. Predator, discussing what has--and hasn't--changed since then.
If you want to join in the reminiscing, Steam is now selling the original for a mere $5.
Aliens vs. Predator is due to arrive in February, with a premium 'Hunter Edition' offering such joys as a replica facehugger, AvP graphic novel and swanky sew-on patch.
You must be logged in to post.


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Welcome to the College of Nursing
The College of Nursing enrolls more than 650 students in our BS, RN-to-BS Online, RN Refresher, MS, and PhD programs of study. Since 1969, our programs have prepared professional nurses for leadership and innovation in health care in Southeastern Massachusetts and beyond.
By providing a dynamic learning environment that promotes analytical thinking, compassion, and creativity, the College of Nursing prepares health care professionals to succeed.
Commission on Collegiate Nursing Education
One Dupont Circle, NW Suite 530
Washington, DC 20036
Phone: (202) 463-6930
Fax: (202) 785-8320
The College of Nursing has received Official Accreditation from the National League for Accrediting Commission.


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By Aly Semigran, Hollywood Staff
When New Girl fans met Nick Miller's mom Bonnie (Emmy-winner Margo Martindale) for the first time (we've overheard plenty of adorable phone calls in which he reassures his ''Ma'' he's alright) in the wonderful, bittersweet episode ''Chicago,'' it wasn't under the happiest of circumstances. Her con artist husband Walt (Dennis Farina) passed away and Nick and his pals went to the crazy Miller household to pay their respects at his Elvis-themed funeral.
At the end of the episode, Bonnie - who ultimately warmed to Jess (Zooey Deschanel) when she saw how much she and her son cared about each other - she pleaded with Nick to come home to Chicago more, if only so that she didn't have to only talk to her dopier son Jamie (Nick Kroll). Well, Bonnie and New Girl fans who want more of that crazy Miller brood may get their wish: Martindale told Hollywood.com that she and the New Girl writers are ''all talking about'' how to bring Bonnie back into the mix. And Walt, too?
Martindale caught up with Hollywood.com on the red carpet at the premiere of her new drama Bluebird at the Tribeca Film Festival on Thursday and revealed, ''We were all talking about it. About maybe Dennis Farina('s character Walt) is not really dead, that he conned his death. And then we could have a meeting of the parents.'' The Millers meeting the Days (Jamie Lee Curtis and Rob Reiner)? We love it already. If only because their meeting would mean Nick and Jess would have a reason for their parents to meet!
Of course, getting to revive her role as Nick's mom on the series (which is already garnering her guest star Emmy buzz) has another pretty sweet incentive: getting to work with Jake Johnson again. ''Isn't he cute? In person he's even cuter,'' Martindale said, adding, ''He's such a wonderful actor. That whole cast is insane talent.'' One big, happy talented New Girl family.
Follow Aly on Twitter @AlySemigran
More: 'New Girl' Recap: Cece's Bachelorette Party and Nick's D**k Pic 'New Girl' Recap: Nick and Jess' Infinite Sexual Tension'New Girl' Recap: A Death in the Family
From Our PartnersStars Pose Naked for 'Allure' (Celebuzz)Which Game of Thrones Actor Looks Least Like His Character? (Vulture)


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Joseph G. Haubrich |
Vice President and Economist
Joseph Haubrich is a vice president and economist at the Federal Reserve Bank of Cleveland, where he is responsible for leading the Research Department's Banking and Financial Institutions Group. He specializes in research related to financial institutions and regulations.
Before joining the Bank in 1990, Dr. Haubrich was assistant professor of finance at the Wharton School of the University of Pennsylvania.
Born in Oak Park, Illinois, Dr. Haubrich earned his bachelor's degree in economics from the University of Chicago and his master's and doctoral degrees from the University of Rochester in New York. He has also been a referee for several professional journals. In his free time, he tends his wildflower garden and his four children.


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Effortless Cotton Elena Shirt
mouse over photo to zoom click for larger image
Effortless Cotton Elena Shirt
The short-sleeve button-up is back, in no-iron cotton and a rainbow of shades—you can never have too many.
- Effortless shirts have been engineered to give an always-pristine, wrinkle-free appearance.
- Neatly welted chest pockets.
- Length: 24" to 27".
- 100% cotton.
- Machine wash. Imported.


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Anthony Stoneware is an American pottery founded in 1966, with the vision and passion to produce functional ceramic ware of high material integrity, excellent design and pleasing aesthetic. We truly enjoy what we do every day as well as feeling good about our work becoming part of the lives of our patrons. From Paul Anthony, "My architectural training and years of professional practice strongly influence my design decisions for the ceramic pieces I make. My forms are generated from designs evolving from functions. Pots have purpose - they are to be used. I work with the hope that in the process of use my ceramic pieces will enrich not only those who use them, but also the purpose for which they are designed."
View Other selections from Anthony Stoneware
For Damaged Items:
Please unpack merchandise carefully and inspect upon receipt. In the event of breakage, please call us immediately (888 362-4789), so that we can go over the procedures for replacing the damaged item(s). Leave everything in the original box, with the packing materials. DO NOT SHIP ANYTHING BACK TO US WITHOUT CONTACTING US FIRST; WE WILL NOT BE ABLE TO ISSUE CREDIT TO YOUR CARD OR STORE CREDIT IF OUR PROCEDURES ARE NOT FOLLOWED, OR IF THERE IS FURTHER DAMAGE TO THE ITEM(S).
For Exchanges:
Items may be exchanged for other items, or for store credit, within a six- month period. Any items sent back to us must reach us in saleable condition. Customer pays return shipping fees.
For Refunds:
We will issue refunds to your credit card if an item(s) reaches you damaged and you do not want a replacement, or if an item has been misrepresented on our website. Misrepresentation must be agreed to by both parties. Refunds for misrepresented items will include shipping fees, and will be issued once the item(s) comes back to us in saleable condition.
No returns or exchanges for personalized or engraved items unless damaged, or received with an error.
No returns for STUDIO DIRECT orders unless damaged; handled at the discretion of the artist.
Lost or incorrectly delivered packages:
You will be given a tracking number when an item is shipped. If the package becomes lost or does not reach you, we will work with you in filing the proper UPS or USPS claim. Refund based on outcome of insurance claim; we are not liable after package has been successfully turned over to the carrier.
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Please ship any (non Studio Direct) returns/exchanges to:
*Gift-wrap is FREE for any Item over $29, OR ALL items in an Order over $99* (* $3.95 otherwise)
*ACG Points cannot be used with any other promotion Like "gift set sale" or "Final Blowout Sale"
*ACG Points are automatically applied at Checkout: Every customer has a "Card", points are accumulative, however, awarded in increments of $25 spent. Points are good for 1 Year Award on the confirmation page, and can be used towards your NEXT order by you or a friend.


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Enrolment is now open!
The journey begins again in September 2014!
You can pay for the courses online here.
However, please read the Terms and Conditions first. By paying for the courses you are confirming your full acceptance of the Terms and Conditions, so it is important to make sure you have read them prior to purchase.
Cardiff Met has been running its first two entirely-online courses via the School of Education since October 2010. Click on the course titles to find out more about them:
Frequently Asked Questions, plus the Terms and Conditions, for the two courses can be found here:


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Hi Everyone! I have released a new bundle and thought it would be fun to do a quick page exchange! Here are some previews of the new kit:
If you submit a page using the Expressions kit you will receive all the pages submitted plus these two pages created by my creative team:
If you submit a page using the Expressions Bundle (on sale 40% off), you will receive all of the pages submitted, the two pages above, and also my grab bag #22 which has 4 all new 12x12 templates in it!
Here are the details....
Guidelines: UPLOADING GUIDELINES HAVE CHANGED SO PLEASE READ
* Each participant will submit at least 1, 12x12 page but not more than 2 using this kit or bundle only (but you may include any commercial use supplies as well). Please put all of your pages on 1 preview page to upload to the gallery to prevent any non-participants from using these pages right out of the gallery.
* Sign-ups are requested for this so that we know who is working on pages. Post here to say you are planning on participating.
* Layouts should be created and saved at 12"x12" and 300ppi starting with a transparent background. Your photo areas should be transparent when you are done.
*I have a quick page photo cutting style for Photoshop and Photoshop Elements here.
* If you are unable to create a .png file, please design your quick page by creating your layout and using a white or black area (whichever is of most contrast to your layout) for the photo placements. Save your layout as a flattened .jpg file at full resolution (unless you are submitting a png file already). Please share this file and then post in this thread that you need help poking the holes for the pictures and I will help do those for you.
* Please name your files as follows to help me track these easier. YourForumName_KitName_qp1.png so as an example, mine would be goldscraps_expressions_qp01.png.
* Post your preview of your quick pages at 600x600 and upload it to the Quick Page Exchange gallery for everyone to see!
* I will need the .png or .jpg file at the full 12x12 size for each quick page you submit. Please do not upload the preview to the QP folder below...just the 12x12 png quick page files.
****NEW***: In an effort to get you the albums much quicker after the exchange is over, we're implementing a new way for us to share the files.
* Please upload JUST THE FULL PNG FILES to the Expressions Quick Page Exchange folder.
* Toward the bottom of the screen you will see an "Upload Files" small window. Click the browse button inside there and navigate to your PNG files and choose that to upload.
* Your computer will then upload the file so it may take a minute or two. After the upload is completed, you will not see anything in this folder or even see anything to tell you it was successful but I'll let you know if there's a problem.
* Please post here that you uploaded so I can make sure it came through OK.
* Once the exchange is over, I will figure out who hasn't uploaded or has a problem with their files and when all is good will make it so that you can see all the files that everyone uploads and then you can download them!
* The submission deadline for this round is end of the day on Monday, October 25, 2010. Please have your images posted and uploaded by then so I can get them out to everyone. I will plan on distributing the pages on October 27, 2010.
I'll keep a list below of who is participating and has uploaded their pages ok.
FJchickie -
techie girl - 2 files uploaded ok.
jessrdgs - 2 files uploaded ok.
altimasport - 1 file uploaded ok.
bunnyscrap - 1 file uploaded ok.
donakat - 1 file uploaded ok.
linds_lim - 1 file uploaded ok.
Gem - 1 file uploaded ok.
mmikes - 2 files uploaded ok.
linds_lim - 1 file uploaded ok.
christellevandyk - 1 file uploaded ok.
phardy1945 - 2 files uploaded ok.
myleigh - 2 files uploaded ok.
denisewitch - 1 file uploaded ok.
Total pages for the exchange so far, including bonuses from Andrea: 15


text: The Near North Chicago neighborhood has 25,000 new residents occupying 10,000 new housing units built since 2000. Along with them have come offices, hotels, eateries, clubs, art galleries and shops. The central location makes whatever isn't there an easy walk or cab ride away. Read more about River North, Chicago


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Back To School Baskets
rollover to zoom
- Contents
- Details
Choose from an assortment of 72 or 120 of our Nibblers® bite-sized cookies.
**Due to our dough mixing process, all of our products may have come in contact with nut oils.
- Approximate Weight:
- 60 Nibblers® bite-sized cookies basket: 1.64 lbs.
- 100 Nibblers® bite-sized cookies basket: 2.5 lbs.
- 200 Nibblers® bite-sized cookies basket: 5 lbs
- Cookies taste best when eaten the same day they are received.
- Nibblers® bite-sized cookies come in a selection of our most popular flavors to please a crowd.
- It takes about four Nibblers® bite-sized cookies to make one cookie.
- Nibblers® bite-sized cookies come in packages of six.
- Brownie Bites are wrapped in half dozens in the same special wrapper with a label to identify each flavor.
- Some tips if you have to save some for later: never refrigerate - they dry out, store in an airtight container with a piece of white bread, may be frozen in an airtight bag.
- Thawed cookies can be warmed in the microwave for up to 10 seconds or a 375 degree oven for 1-2 minutes.
- Frozen cookies can be warmed in the microwave for 20-30 seconds or a 375 degree oven for 1-3 minutes.
- All Brownie Bites contain nuts.
IMPORTANT NOTICE: We apologize for the inconvenience but this gift is not currently active.


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Indiana revives program with win over Mizzou
Watch: Dak Prescott stiff-arms defender on 56 yard TD run
TMZ runs down Adam Silver, gets his comments on NFL
Missouri Looks Ahead To South Carolina Next Week… And Lose
Evander Kane: "I know I can score 50″
Vine: Michigan defense scores "fat guy" touchdown
PHOTO: Utah's Clay strikes Desmond Howard's Heisman pose
Watch: Blake Sims throwing bombs
VINE: Iowa's Damond Powell redeems himself with one handed
Video: Bowling Green's Ryan Burbrink Makes Eye-Popping One
VIDEO: UGA Freshman Isaiah McKenzie returns punt for TD
VIDEO: UGA offensive lineman gives Sony Michel assist into e
ESPN: Spurs are the best franchise in sports
…Meanwhile, in Newcastle
Will the NHL's rule changes increase scoring?
Dugout Digest – the Dodgers make it four
How did Josh Lucas go from the next big thing to 'The Myst
Penguins roll out awesome new alternate uniforms
Braves fan catches homer in popcorn bucket
Incredible billboard for the Tampa Bay Lightning
Gunners Need to Show Spirit Against Aston Villa
Seth Curry, shooting for a chance
End of season post-mortem: San Diego Padres
What comes next for Greg Monroe?
Is Devin Hester a Hall of Famer?
The longest homers for the week ending September 18th
Fan Stadium Review- The Good, The Bad, And The Ugly Of 49ers
Jake Locker is really proud of his chicken coop
Dugout Digest – do or die for the Brewers
Charles Barkley throws out first pitch at a Cubs game. Fails
Regardless of how it is reported, poll finds NFL is losing f
Are the Dallas Stars as scary as they look?
Josh Gordon still hasn't sold a car
Who will be the first head coach fired?
End of season post-mortem: Cincinnati Reds
Enjoy "The Ballad of Brian Hoyer"
Peyton Manning subtly connects legal weed to Papa John's b
Take a gander at Tom Brady's pre-NFL résumé
2015′s breakout team: the Cleveland Indians
MLS Changes League Logo in Preparation for 20th Season
End of season post-mortem: Philadelphia Phillies
Darrell Hammond Is The New 'SNL' Announcer
John Oliver Has Become The Most Important Person On TV
Dugout Digest – Athletics finish collapse with a thud
While you were sleeping, the Angels won the AL West
Week 3 NFL Game Watchability Rankings
UEFA Champions League Wednesday Roundup: Matchday 1
NHL players guess their rating in EA's NHL 15
John Henry Offers a Glimpse Into Liverpool's January Trans
VIDEO: Jerome Boateng's Golazo Puts Bayern Munich Past Man
2013 Archives
2012 Archives
2011 Archives
2010 Archives
2009 Archives
NHL Blogs
Fan Attendance: A Look at Game 1
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Trademarks used herein are property of their respective owners.


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Bookcase features 12-1/8" deep shelves that adjust in 1/2" increments, except for the bottom one. Heavy-gauge steel frame has baked enamel finish over rust-inhibiting phosphate pretreatment. Bookcase is certified by SCS to be in compliance with specific indoor air quality emission requirements and meets or exceeds applicable ANSI/BIFMA standards.
Dimensions: 34 1/2" Wide x 12 5/8" Deep x 59" High
Shipping Weight: 77 lbs.


text:
$9 for 3 Wine Aerators - Shipping Included ($59 Value)
3 Wine Aerators
- Retail $59.00
- You save 85%
- You Pay $9.00
Expires 1 months from date purchased
Limit 5 per customer, may purchase 5 additional as gifts. Shipping included within the 48 contiguous states; Does not ship to P.O. Box Addresses, HI or AK. Product will be automatically shipped to address entered at checkout within 3-4 weeks of purchase - no voucher redemption is necessary.. This voucher has no cash value. Cannot be combined with other offers. Total voucher value must be used in 1 order. Tax & gratuity not included. Valid for US Residents only.


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Next, you'll be asked to connect with Twitter. Rest assured, we will never send a tweet from your account
without your permission.
We will send you an email with an invite soon.
RT @pitstopsforkids: RT @kdworkin: Top 10 Things to Do w/ Kids Across America via @trekaroo @GoVisitHawaii @enjoyillinois @VisitIndiana...
The biggest hotel in #Indiana is in #Indy. What hotel is it? #hoosiergram
Will you take a 1-minute survey about travel planning on your mobile device for us? #thankyou
Follow @VisitIndiana on Twitter


text:
(skip this header)
Texas 'Goddesses' rally for open-carry
Top Stories in Local
Governor confident ambush suspect will be caught
Top Stories in US & World
Mission Solar in production mode
Top Stories in Business
Cosmic comeback for Cowboys
Top Stories in Sports
Kitchen remodel: A new coat of paint makes huge impact
Top Stories in Food
Meet the villains of "Gotham," the fall's hottest new show
Top Stories in Entertainment
Bathroom design options for a spa-like retreat
Top Stories in Lifestyle
Today's Editorial Cartoon: Sept. 22
Top Stories in Opinion
2014 Subaru XV Crosstrek hybrid — a multi-purpose tool that works.
Top Stories in Cars
German employers struggle to find apprentices
Top Stories in Jobs
Guide to San Antonio and South Texas
Best S.A. neighborhoods for foodies
Top Stories in Homes
The Vikings defeated the Texans on Sunday, Dec. 23, 2012, in Houston.
Photo By Smiley N. Pool/Houston Chronicle
© Copyright


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SKY by Marguerite H. Roberts
by Marguerite H. Roberts
Reception:Thu, Apr 18, 7pm
Iconic images of the West always includes the vast expanse of sky showcasing the openness and largeness of this section of our country. John Ford directed award winning western films shot around Kanab, Utah and Monument Valley adding to the legends and myths of the West. He also captured the incredible landscapes adding to the world's vision of the Western United States.
In the Salt Lake Valley we have the Wasatch Mountains to the east and the Oquirrh Mountains on the west side along with the Great Salt Lake. This combination of mountains, valley and water creates incredible "SKY" images on a daily basis. We are quite fortunate to be blessed with such openness and beauty. Our Salt Lake sunsets and sunrises are spectacular and visitors remember them as well as residents. Over the years I have captured numerous sunset and sunrise photographs as well as clouds during different times in a day. Additionally, when I travel I look for that special time of the day when the light is perfect and the sun's colors illuminate the sky. One image is a gentle reminder of the journey and it stays with me.
This collection of photos deals directly or indirectly with the sky and light in different seasons and all the colors and mystery we can see, even though many of us in Salt Lake City may take our sunsets and sunrises for granted having become accustomed to mother nature's gifts to us. This is a visual smorgasbord of landscapes within our valley and outside our state. I hope you will be drawn into the vivid pinks, oranges and reds, and the muted pastels with the rest of the color spectrum along with the abstract, the imaginary and the actual. Even when the "Sky" is not visible or the main focus of the image, as in the Moose & Wildflower photo, it played a major role in capturing a great image.
Take time to reflect on the expanse and beauty of our sky and be awed by our environment and its creator.
Location: Anderson-Foothill
Contact Information: (801) 594-8611


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Local Weather Cameras
Spilimbergo, Italy
A local camera is not available for this location.
Here is the Featured Daily Camera.
Live weather camera images from:
Stowe Mountain Ski Resort, Stowe, VT 05672
Weather Links for Spilimbergo, Italy
Weather News
Other Top Weather Headlines
Huge California Wildfire Grows Bigger
As an expanding wildfire in Northern California kept nearly 3,000 people from their homes, teams sought to find out how many…More >
Philippine Death Toll Rises To 10 After Storm
The death toll from Tropical Storm Fung-Wong – known locally as Mario - has climbed to ten in the Philippines, as the number…More >
Remembering Hurricane Hugo 25 Years Later
The Category 4 hurricane struck 25 years ago Sunday, claiming 13 lives in South Carolina - out of 49 total killed - and…More >
WeatherBug Featured Content
Green Living
You too can help save our planet and put money back in your wallet. Learn how you can take the first steps to reduce your environmental impact, including driving green, easy ways you can conserve water, and energy saving tips. To learn more and discover the benefits of going green, visit WeatherBug's green living section. More >
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Description:Intel Xeon 2.8GHz 2MB 800MHz BASE ProcessorPart Number(s)Manufacturer Part# 405635-B21
HP Processor Kits:
Manufacturer Part# 405636-B21
This is the full processor option kit. It includes the
Processor(s), Heat-Sink(s), Fan(s), Thermal paste
and VRM (Voltage Regulator Module) where required.
Overview:The platform of choice keeps getting better. Designed for dual-processor server and workstation platforms Intel Xeon processors give you the freedom to focus more on your business and help you gain greater flexibility and lower costs. Put the Intel Xeon processor's latest platform innovations to work to accomplish more than ever before.
CategoryProliant Processor
GenerationDL120 G2
Part Number405636-B21
Products ID458260
Product TypeProcessor Upgrade
Processor TypeIntel Xeon
Clock Speed2.8GHz
L2 Cache Size2MB
Front Side Bus Speed800MHz


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A Cocktail from Colin Field
Colin Field, of The Ritz Paris's Hemingway Bar, was named the best bartender in the world by Forbes in 2001. Today, he shares one of his own recipes with NOWNESS, a champagne cocktail that he describes as "France in a Glass."
"In a tumbler, put one sprig of fresh mint, but don't take off the leaves. The first 2/10 of the glass should be calvados—which is for me an apple cognac, distilled twice, aged in barrels, not a brandy, which is a horrible term for that fantastic product. Then add one small teaspoon of sugar. Now, stir together, but do not muddle—bartenders want to get a great big baton out and bash it about, but we don't want that. Then take some clarified apple juice—think liquid gold, that you can see through—add lots of ice and, finally, top up with champagne. About 5/10 of the cocktail will be champagne."I am Drinking Stars!, a history of Champagne over 400 years, is published Oct 26 by Steidl.


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Chat tonight! I will continue to be on assignment. For those of you who may have forgotten, chat gets started around 9:30 PM for those of us on the east coast, 8:30 PM for those of you in Chicago and 7:30 in other parts of fly over country such as Denver. I guess that means 6:30 PM on the left coast. If my calculations are correct everyone in NZ needs to join us at 1:30 PM Thursday and Australia at 11:30 AM on Thursday for those in Sydney and eastern Oz. It will be an ungodly 3:30 AM in Israel and Helsinki, 2:30 AM in Paris, and Berlin, and 1:30 AM in London. Of course it is all worth the sleep deprivation. Come in early and see who is here. Don't be late!!!!! (I hope I have the time changes down.If not, let me know!)
And a note from our fearless leader:
James referred me to this thread, and basically, as I told him, it seems that our current chat solution has gotten buggy and probably behind the times. Lots of people having problems with it.
There's no need to take up a collection ... I'm happy to pay for the chat room rent from the proceeds of forum adverts (including the dreaded Meebo), but I'm going to invite you folks to form a task force and get on Google in search of an affordable chat solution that's in the same price range of $10/mo or less. You find one that suits you all, I'll get it installed and paid for. I do think it's probably time to jump ship from Parachat, though.
The fun starts HERE!!!!


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Essential Ribbed Turtleneck: You can wear this classic turtleneck sweater anytime, anywhere! Imported.
Buy 2 for $24.99 each
*Buy-2 Deal not available on markdown colors
Read what customers are saying about this product:
Rating: 3.00 out of 2 votes cast
Well Made but TOO SHORT
I have these sweaters in several colors. The other reviewer is correct, shrinkage has not been taken into acct when sized. I would LOVE to have these sweaters be 2 inches longer so I didnt have to pull them down all day.
Chicago, Illinois
Nice, but....
I like this sweater, but it does shrink considerably, even when washed according to the instructions--at least an inch off the sleeves and length. Definitely order up if you're wavering between sizes.
Concord, CA
Click here to read all of this product's reviews


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I just got the proofs through from our photo shoot; would any of y'all want to look through them and tell me which ones that you think are best? There are only 39 pictures to look through....if you do, I can send the sign on and password on a PM....
Printable View
I just got the proofs through from our photo shoot; would any of y'all want to look through them and tell me which ones that you think are best? There are only 39 pictures to look through....if you do, I can send the sign on and password on a PM....
I'd love to see!
Me too!
Erin, the first block of soap I got (that Christina got a piece of) is as you described. I loved that it left me feeling clean without any perfumes or cover-ups. But. POKEY. I didn't realize and man, it scratched the heck out of me. That's why I decided to try the Dudu. The scent it leaves on the skin isn't strong, so I'm okay with it, but once the 3 bars are over, I'll go back to the other black soap.
I think G would love it even if he doesn't know who they are! Do it!
Bobbie's at her 5-hour course. I didn't even think about it, but it goes till 9:30 and it's about a half hour away. That's a really late night for me to be out! Especially during the week.
Called the RE's office today and spoke with the receptionist. She said she'd ask the doctor what he wanted to do, either come in for testing or wait it out for a while. Took down my phone number and said she'd call me back, and never did. :headbang:
Oh man how frustrating!
You'd think that a RE's office of all places would know not to do that. How frustrating for you, Mandy!
Ashley, yes I want to see the pictures. I forgot to say how your Travis story was. I think the Whose Line questions would be funny, I say do it.
Maybe I will talk dh to taking me to the Muppet movie for our Anniversary this month, heh. I doubt that will happen. We usually do dinner and movie for our dates. I am not even sure what is playing. He always wants to see a action movie. Oh I know, he wants to see Tin Tin. Never heard of that movie, but he is excited, he read the books when he was a kid.
mandy, that is so frustrating! I wish people would return phone calls before they go home.
Bobbie's 5-hour course was essentially a waste of time. I mean, she got her certificate so she can schedule her road test, but the guy was a conspiracy theorist and talked mostly about how the government put RF chips in all our clothing and tracks where we go. On one hand it's funny, but then I think about all the 16-year-old city kids he was blathering to and I don't find that funny at all. The scary thing is he's been 'teaching' at this driver school for 16 years. Bobbie said he only talked about driving about 5% of the time...the rest was how the government was watching us.
Wow Chrissy :shocker:
Jeez that is crazy sounding. They should find someone else for that course!
Yeah it's Friday! Going to do a bunch of errands tonight that normally would have waited until tomorrow but we are supposed to get a winter storm. I have heard anything from 4-8 inches.
Talked to DH and MIL last night. Sounds like it's definitely an option on the table. Right now she's not making any moves until she is 62 so it would be a little over another year. The little more ideal thing would be her own apartment BUT not sure if the money will be there for that. Also it would change things if she found a job by us or in Milwaukee. Health insurance is a biggie and not sure how the new laws coming up might affect that. She's older, smoker, a bit overweight and has a history of cancer so definitely not easy to get insurance privately...and the state high risk plan isn't cheap. She would definitely need privacy because she said much as she loves DH, he can really irritate her sometimes. Not me though. :) I'm a perfect daughter in law. And than she says we have to really think about it and if we want to give up Saturday afternoon sex on the living room floor. OMG. Usually we ignore her when she get TMI on us. And she said she would really like to be able to do some plants and garden. I would LOVE that. She's great at that and our yard is pretty much a blank slate....I just didn't want too much outdoor work too quickly.
The other thing floating around out there is her dad. Grandpa is alone now with grandma gone and he's 90 and still pretty healthy. She would love to move up here with him and than they could either rent or buy a little condo maybe.
Seriously, what century are we living in? http://www.cbsnews.com/8301-201_162-...acial-couples/
Wow, Suja. That is pretty messed up. Some people are so blatantly ignorant. I'm glad I live in such a liberal area and don't have to deal with that attitude.
Sounds like there are some options on the table Jennifer. Thats great!
Seriously, WTF is wrong with people??
Um... your banning interracial couples that makes you a racist you twit! :pokey:Quote:
"I am not racist. I will tell you that. I am not prejudiced against any race of people, have never in my lifetime spoke evil" about a race, said Thompson, the church's former pastor who stepped down earlier this year. "That's what this is being portrayed as, but it is not."
And in other bigotry news, http://content.usatoday.com/communit...army-boycott/1
Aelith hi!
Um, yeah if it walks like a racist duck and quacks like a racist duck, it's a racist duck.
Yeah!!!! Saw that Dexter was renewed for 2 more seasons!!!! :)
They have turned down homosexual couples seeking services for refusing to break up with each other.
They have lobbied to be exempt from the equal employment clause so they do not have to treat their LGBT employees (if any) the same as they would the others.
They have threatened to close up shop and provide no services to anyone when NYC required charities that do business with them to offer domestic partner benefits to everyone.
They tried to lobby the Bush administration into not providing funding for local governments that had active laws against discrimination on the basis of sexual orientation.
When New Zealand tried to repeal their sodomy laws to make it okay for adults of the same gender to engage in consensual sex, they tried to get that blocked.
Und so weiter.
Another huge problem for me is that they raise funds privately, accept funds from the government ("our money"), yet provide no disclosure on what they're spending this money on. They do not have to file financial disclosure forms because they are a religious organization, and therefore exempt. Anyway, I know they do a lot of good, but there are lots of organizations that do a lot of good and do not discriminate. IMO, if you replace the term 'LGBT' with something else - women, African Americans, Hispanics, Jews - and it's not okay to do that to them, it's not okay to do it to anyone else either.
I've know several people who belonged to the Salvation Army in my life (my mother's cousin, some people I with whom I went to high school). That being said, every single one of them were/are a bit on the bizarre side and were definitely homophobic (and lots of other kinds of phobic too). I stopped donating to SA a long time ago.
Hey Aelith! It's good to see you back here!
Yeah I don't drop into the red buckets either. I mean doing good is great BUT it doesn't have to come at the expense of others.
I haven't seen the last Dexter yet but I basically know the big spoiler I think....and actually saw it coming 2 episodes ago. But I love the show anyway. And all I can think of when I see Gellar is that Admiral Bill Adama is not supposed to be a nasty freaky person. LOL Probably a fun role for Edward James Olmos to play though after BSG.
I just love Michael C Hall....he's so great at acting.


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February – October 2014
CUNA Governmental Affairs Conference
One Cause. One Voice.
Plan to attend the nation's capital for the 2014 CUNA Governmental Affairs Conference (GAC) to Unite for Good.
Rally for the powerful credit union cause and connect with leaders from across the United States.
CUNA GAC is the biggest week of the year for credit unions. More than 4,000 credit union people come together to:
• Hear from influential legislators, policymakers and credit union experts on the political landscape and its effect on credit unions
• Identify new strategies for building and maintaining America's awareness and trust
• Network with credit union leaders
• Attend breakout sessions on the hottest issues in the movement
• Tour the largest vendor showcase in the financial services industry
• Tell Congress our story at state Hike the Hill visits
Please wait for word from Kelly Fuhlbrigge for registration information!
This past year, CUNA and the leagues launched a shared strategic vision for credit unions nationwide: Americans choose credit unions as their best financial partner.
To make our vision a reality, we must come together to remove barriers – like the threat to the credit union tax status - create awareness and foster service excellence. We all need to Unite for Good.
We have an opportunity to accomplish a lot for the movement this year, and need your involvement to make it happen. Come to Washington, D.C. to tell our shared story and protect the credit union difference.
Click here for the flyer!
Follow this link to learn more and register.
Click here to download or print the flyer!
Plan to join peers in Saratoga New York for the 2014 Leadership Conference. The program is being expanded this year to provide additional education but there will still be plenty of time to enjoy the beautiful scenery, shopping and, if you are in the mood, spend the evening at the Saratoga Casino and Raceway. Review the links below for program information and to register for the Conference. The registration page also identifies the contact number for the hotel – be sure to register quickly since the special discounted space is limited. We continue to work on some value added extras for the event so check back for more information.
Ten scholarships for full registration are available to credit unions under $50 Million in assets and a discounted registration fee of $299 is available for young professionals (under the age of 35). Alloya Corporate Credit Union is also offering one scholarship that will provide an all-expense paid conference experience to one individual. The Christine M. Gross Memorial Scholarship, is offered to a member of Alloya, either as a capitalized member or an associate member in the $20 million and
under asset size. Details on the program can be found here.
Click below for more information:
2014 Leadership Agenda
2014 Leadership Brochure
2014 Leadership Registration Information
Leadership Conference Scholarship Application for Small CUs
Carie Schelfhaudt, Director of Digital Marketing, McDougall & Duval Advertising
An active player since the inception of social media, Carie directs all social and digital marketing strategies for McDougall & Duval's clients, a majority being in financial services. She is a sought after speaker and writer, presenting at conferences and regularly writing columns to educate others on the best practices for online and social media marketing at backs and credit unions.
I. Writing a Social Media Policy
Writing a social media policy that satisfies the needs of human resources, marketing and compliance can be an intimidating task. But have no fear! Knowing what not to do when making a policy can make the process so much easier.
II. Social Media Training 101 for Credit Union Employees
New guidelines from regulators say financial institutions need to train employees on official, work-related use of social media. Learn the key components of developing an employee education program for your financial institution.
III. Content Tips for Financial Marketers
Expecting the unexpected and planning ahead for quick responses are critical to your new online marketing strategy. Now is the time to develop a plan.
Click here for the Registration Flyer.
Premier Wine Tasting Event!
Date: Friday, October 17th
Time: 6:30 p.m. to 9:00 p.m.
Place: Mohegan Sun
Dress: Black Tie/Cocktail Party
Click here to download the flyer!


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I am guessing this is one of the world's happiest dogs! I have a dog that LOVES to chase balls. That was him on the picture you clicked to get to this story. He would do it until he literally can't walk any longer. I have played fetch with until I thought my arm was going to fall off and he was still ready for more. I am thinking I need to build something like this. However, I think my dog would do this until it killed him! How long do you think this pooch does this, I am betting its about ALL DAY!
Rush Limbaugh 11:00 AM - 2:00 PM
On Air Now.


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Villa 11570, Bangtao
- Bangtao, North Phuket
- 3
- 6
- 4
- Ref No. 11570
THB 370 - 650/day
This villa combines simple elegance of Thai and Balinese design. You'll be captivated the moment you enter Villa. Let your gaze wander over the luxuriously appointed living area toward the sparkling pool enveloped by lush tropical greenery. The large living space extends seamlessly outside to an open terrace perfect for cocktails and small party. Surrounded by gardens full of color and beauty,
This villa offers 3-luxury bedroom in terms of space, high ceilings, Air- conditioning through out the villa, fully equipped kitchen, A Smart TV with online interactive media, Satellite Box, DVD player, Internet Wi-Fi through out the villa, Maid's quarters, Large pool, BBQ, Gated estate entrance, Car Parking, 25 minutes to Phuket Airport.
Main bedroom come with a walk in closet and private bathroom. The two guest bedrooms are situated just a few steps away and are separated from the main building.
Guestrooms both have private bathrooms with toilet, vanity and romantic outdoor waterfall shower.
Just 500 meters to the wonderful Bangtao Beach, restaurants, and Laguna area, Villa is easy access to internationally renowned hotels like the Angsana, Dusit Thani and The Banyan Tree.
View full map
Property Details
- Bedrooms3
- Sleeps6
- Bathrooms4
- ViewGarden View
- TypeHoliday Villa
- Swimming PoolPrivate Pool
- Bedrooms Description2 King Size-bed and 2 Single beds
- Dining Room1
- Living Room1
- KitchenFully equipped kitchen
- EntertainmentLCD TV , DVD player and Cable TV
- InternetWifi internet
- Distance BeachWalking distance
- Distance Airport20-30 minutes drive
- Distance Phuket City30-40 minutes drive
- Distance Golf Course10-20 minutes drive
- FeaturesChildren Allowed, Fully-furnished, No Pets, No Smoking
Interested in this property?
- Office:
- +66 (0)76 325 915
- Mobile:
- +66 (0)82 423 0203
- Email:
- [email protected]
Holiday Rental Rates
- Period Rates
- Low - -
- Mid - -
- High - -
- Peak - -
Holiday rental minimum stay: 7.
Rates are inclusive of 10% service charge and 7% VAT.
Please note: These rates are subject to change. Final rate will be confirmed prior to payment of deposit.


text:
Map It
Map City Services
Metro Newsroom
LouisvilleKY.gov Links
Tuesday September 4, 2007
An Air Quality Alert has been declared for Tuesday, September 4, 2007 for the Louisville area.
Forecast for Tuesday, September 4: Fine Particle Pollution - 107 Ozone - 104
At this level, the air is expected to be Unhealthy for Sensitive Groups. Sensitive groups include active children and adults, and people with lung diseases, such as asthma. These groups should reduce prolonged or heavy exertion outdoors.
The Air Quality Index (AQI) is an index for reporting daily air quality. It tells you how polluted your outdoor air is, and what associated health effects might be a concern for you.
Local air quality affects how we live and breathe. Like the weather, it can change from day to day.
See current and forecasted air quality, or call (502) 574-3319.
Learn about the health effects of poor air quality.
Learn clean air tips that can make a difference.


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Some pet lovers swear they can. While there's no scientific evidence to back it up, many people say their pets definitely know when they're pregnant – or at least can tell that something's up.
Anecdotal evidence includes dogs following more closely than usual and barking or growling in protection and cats rubbing against – or sitting on – a pregnant mom's belly. Even wild animals, like snakes, have been reported to sense pregnancies – and either chase the pregnant woman or flee from her!
One expectant BabyCenter mom says that whenever she lies down, her cat lies right next to her and puts one paw on her belly. Many suggest that their pets knew they were pregnant before they did.
Your pet may be sensitive to changes in your mood, behavior, body language (you may be a bit slower and more awkward), or body chemistry (all those raging hormones!)," explains animal behaviorist Nikole Gipps.
You'll want to make sure to give your pet at least as much attention as usual, because a pet that starts to feel neglected may act out in ways that are less than endearing, says Gipps.
Nikole Gipps has more to say about how animals behave when someone in the house is pregnant. Read her expert opinion.
Post your questions in Mom Answers.


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Women's Mush Frio Ballerina Mesh
Item# 4331
Everyone who wears flip flops knows the feeling. It comes once a year, and it's one of the saddest days we have to go through. I'm talking about the first day after summer when we realize that it's too cold to wear flips. Sorry to bring up any bad memories, but we think we can help with the Mush Flyweights Collection. Our Mush Frio Ballerina Mesh brings all of the things you love about our Mush flip flops into a stylish package you can wear all year long. That's right, I'm talking about the super lightweight, foot–conforming Mushiness that you thought you had to put away at the end of summer. Well…not anymore. Flip Flop lovers rejoice.
Product Actions
Additional Information
- Our incredibly light EVA sole makes it feel just like you're wearing a flip flop... just without all the flipping and flopping.
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- Lightweight mesh upper.
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- Its light weight and collapsible design make it ideal for all kinds of traveling where luggage space is at a premium.
Product Reviews
Reviewed by 1 customer
- Fast drying
- Feminine
- Lightweight
- Choice of colours
Best Uses
- Beachwear
very light and great to pop on for a beachwalk or for swimming pool


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Piles of eviction and foreclosure notices are tucked away in a yellow folder. Sean Kelley, his wife and four-month-old son could be homeless after May eighth. The bills started to pile up in January when Kelley was shot in the head in an attempted robbery."He squinted his eyes up, and he had this gapped tooth in his mouth, and he just shot the gun," Kelley explained. "I felt something rattling in my mouth, and it was the bullet in my mouth, and that was the last time I saw something."It is a miracle Kelley survived, but he has been completely blind ever since. He can't smell or taste anything. The shooting happened just eight days after the birth of his son. When the story aired last week on Fox 2, the newsroom was flooded with phone calls and emails from people looking to help, but when your life has been turned upside down, even getting help takes planning."We do have to prioritize how we spend the money and how far we got to go and the distance and make sure that we [are] utilizing the money, utilizing the gas for the right purposes," Kelley said.Which is why the Kelleys had to wait until Monday to set up a fund. The Sean Kelley Support Team Fund is now open at Flagstar Bank. Kelley left his job just before the shooting. The Kellyes were already behind on their mortgage, and now the medical bills just keep coming.We forwarded some of your messages of encouragement. Kelley couldn't believe it."I can't believe that [there are] still good people out there," he remarked. "I want to say thank you from the depths and the bottom of our heart.""This is something I don't wish on my worst enemy for me to wake up and... ultimately look at all this darkness."But there could be a light at the end of the tunnel. Kelley was told he would never see again. However, doctors now say he could regain sight in one eye. Kelley said that is all he needs to see his family again. "I miss seeing life, but most often I miss seeing my wife and my children," he said.
25 FOX DriveDedham, MA 02026
Phone (781) 467-2525


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Genome Scans Find Clues to Childhood Cancer
In the first genome-wide association study of a rare cancer, researchers have identified common genetic variants that may increase the risk of neuroblastoma, a childhood cancer of the nervous system.
Risk factors for the more aggressive forms of neuroblastoma may reside on a region of chromosome 6, according to a report published online last week in the New England Journal of Medicine (NEJM). The region was not previously linked to the disease.
Little has been known about susceptibility to neuroblastoma. The disease often begins in early childhood (or before birth) and initially affects the nerve tissue of the adrenal glands. Many researchers have thought that mutations in several major genes would largely determine the inherited component of the disease. Read more
Mammography Plus Breast Ultrasound Yields Mixed Results
First-year screening data from a study comparing ultrasound with or in addition to mammography in women who have increased breast cancer risk indicate that combining the two tests has benefits and drawbacks.
Adding a screening ultrasound to routine mammography revealed 28 percent more cancers than mammography alone. However, the addition of ultrasound to mammography also resulted in a fourfold increase in false-positive findings - that is, screening results leading to a biopsy that revealed no cancer. Read more
Genome Scans Find Clues to Childhood Cancer
In the first genome-wide association study of a rare cancer, researchers have identified common genetic variants that may increase the risk of neuroblastoma, a childhood cancer of the nervous system.
Risk factors for the more aggressive forms of neuroblastoma may reside on a region of chromosome 6, according to a report published online last week in the New England Journal of Medicine (NEJM). The region was not previously linked to the disease.
Little has been known about susceptibility to neuroblastoma. The disease often begins in early childhood (or before birth) and initially affects the nerve tissue of the adrenal glands. Many researchers have thought that mutations in several major genes would largely determine the inherited component of the disease.
The new results suggest that different types of genetic changes, including some common variations, contribute to susceptibility. The findings also suggest that it should be possible to identify the common risk factors using genome scans, according to the researchers.
"This study is an important proof of concept," said lead investigator Dr. John Maris of the Children's Hospital of Philadelphia. "There was a real possibility before we began that we might not find any common variants, but the results clearly show that common genetic variants contribute to the risk of neuroblastoma."
Neuroblastoma remains one of the most challenging childhood cancers. More than 90 percent of patients with localized neuroblastomas survive, even when regional lymph nodes are affected. But more than half of all patients have a more aggressive form of the disease that is often fatal.
There are approximately 700 cases in the United States each year, yet despite these small numbers, the study was large. DNA came from 1,700 neuroblastoma patients and twice as many children without the disease. The patient samples had been collected over a decade by the NCI-sponsored Children's Oncology Group.
The researchers plan to analyze up to 5,000 neuroblastoma patients in the coming years. They are also investigating other types of genetic variation, such as changes in the number of copies of genes. Preliminary results suggest that these also play a role.
"There clearly are other variants that we have not found yet," said Dr. Hakon Hakonarson of Children's Hospital of Philadelphia and the report's senior author. "This is an ongoing study, and our hope is to identify the bulk of the underlying genetic factors that predispose to neuroblastoma."
The chromosome 6 variants - which include three single nucleotide polymorphisms (SNPs), or single-letter changes in genetic code - occur in two overlapping genes. The researchers are "re-sequencing" the entire region to identify the precise source of the risk.
The absolute risk conferred by the chromosome 6 variants is extremely small, and therefore these SNPs, on their own, would be of little value in screening.
"This is a terrific study," said Dr. Stephen Chanock of NCI's Division of Cancer Epidemiology and Genetics, who was not an author. "Many have thought that the genetics of rare childhood diseases would be explained by a couple of rare mutations, but this study tells us that the genomic architecture is complex and that different types of genetic variation play a role."
Neuroblastoma could offer researchers a rare opportunity to study the interactions of genes and environmental factors in a complex disease, Dr. Chanock added, noting the relatively short time between conception and the development of the cancer.
—Edward R. Winstead
Mammography Plus Breast Ultrasound Yields Mixed Results
First-year screening data from a study comparing ultrasound with or in addition to mammography in women who have increased breast cancer risk indicate that combining the two tests has benefits and drawbacks.
Adding a screening ultrasound to routine mammography revealed 28 percent more cancers than mammography alone. However, the addition of ultrasound to mammography also resulted in a fourfold increase in false-positive findings - that is, screening results leading to a biopsy that revealed no cancer.
The results, published in the May 14 Journal of the American Medical Association, come from a 3-year study of approximately 2,800 women led by the American College of Radiology Imaging Network (ACRIN). The study, ACRIN 6666, was co-funded by NCI and the Avon Foundation, and included participants from 21 different sites.
Of the 40 total cancers diagnosed within 12 months of initial screening, 8 were not detected by either modality alone or the combination of the two, but were discovered later during the 12-month period, for a rate of 3 cancers missed per 1,000 women screened. Overall, mammography alone showed 20 cancers (50 percent of all cancers detected) for a cancer detection rate of 7.6 per 1,000 women screened, while the combination of mammography and ultrasound revealed 31 cancers (78 percent of all cancers detected) for a cancer detection rate of 11.8 cancers per 1,000 women screened.
"Adding a single screening ultra- sound to mammography will yield an additional 1.1 to 7.2 cancers per 1,000 high risk women, but will also substantially increase the number of false positives," wrote the study's principal investigator, Dr. Wendie Berg, and colleagues.
The results raise a number of issues, said Dr. Christiane K. Kuhl, from the University of Bonn in Germany, in an accompanying editorial. They include whether the high false-positive rate associated with adding ultrasound to mammography is worth the benefit of the additional cancers found, and whether MRI may end up being a superior option given the strong results seen with it in a recent study. "Individualized screening schemes tailored to the individual risk and to the personal preferences of a woman may be the way to consider how to screen for breast cancer," Dr. Kuhl concluded.
Follow-up continues in ACRIN 6666 and will include another screening round with mammography and ultrasound at 24 months from study entry, as well as an MRI within 8 weeks of that screening. Reporting of the final results is anticipated in 2009.
Sugar and Signals: EGFR's Dual Role in Cancer
The epidermal growth factor receptor (EGFR), a surface protein found on many cancer cells and an established drug target, is best known for relaying signals into cells that spur their growth. But researchers have now discovered another role for EGFR. The protein helps a cell maintain an adequate supply of the essential nutrient, glucose, according to research in the May 6 Cancer Cell.
Dr. Isaiah Fidler of the University of Texas M.D. Anderson Cancer Center and his colleagues found that EGFR stabilizes another protein on the cell surface, called sodium/glucose cotransporter 1 (SGLT1). This protein channels a constant supply of glucose to cancer cells. A prolonged period without the sugar can cause a cell to destroy itself through a process of self-cannibalization known as autophagy.
The discovery of a second important cellular function of EGFR could help explain why drugs such as erlotinib (Tarceva) and gefitinib (Iressa), which target EGFR signaling, are effective against only a small minority of cancers that express high levels of this protein, the researchers say.
By maintaining proper glucose levels and preventing starvation, EGFR may help tumor cells survive chemotherapy and drugs that inhibit cell signaling. To eradicate these tumor cells, it may be necessary to inhibit both EGFR's glucose-related activities and growth-promoting signals, the researchers conclude.
In an experiment, the researchers blocked the EGFR protein itself, rather than its signals, in prostate cancer cells, and the cells died through autophagy. An accompanying editorial predicts that "this exciting new study" will broaden efforts to target EGFR both as a growth promoter and "as a sweetener."
Two Proteins Interact to Turn Moles Cancerous
Researchers at the Pennsylvania State University College of Medicine have found that two proteins, B-Raf and Akt3, cooperate to change the cell-signal pathways that transform benign moles into melanomas. Their report appears in the May 1 issue of Cancer Research.
Moles (or nevi) are tight clusters of pigment-producing skin cells called melanocytes. These cells are normally distributed evenly between the top two layers of skin, the epidermis and the dermis. The average person has between 10 and 40 moles on their body, usually benign. However, with genetic changes that are still being discovered, nevi can transform into melanoma, which represents fewer than 10 percent of all skin cancers but accounts for 75 percent of skin cancer deaths.
The study team examined a mutation that is found in about 90 percent of moles and approximately 60 percent of melanomas: a single nucleotide change in the B-Raf gene that causes expression of a mutated form of B-Raf protein. Previous research had shown that this mutation alone was insufficient to produce melanoma, so the team tested it in mice with modified levels of another protein, Akt3, that shows deregulated expression in the disease and is known to interact with B-Raf in cell signaling.
They found that the cell-signal pathways associated with Akt3 and normal B-Raf (PI3k and MAPK, respectively) do not inhibit one another in melanocytes, but in melanoma cells where B-Raf is mutated and Akt3 is active, cross-regulation is evident, resulting in decreased MAPK activity and significantly higher activity of PI3k - both signatures of melanoma. Together, the B-Raf mutation and normal Akt3 levels encouraged cells to grow without regard for attachments to surrounding tissues, marking the transformation of melanocytes into melanoma.
When the two proteins were inhibited in melanoma cells, tumor development slowed and apoptosis increased, prompting the researchers to suggest that "therapies for human patients should simultaneously target these signaling pathways for maximal clinical efficacy."
Nutlin-3a Induces Senescence through p53
Although the tumor-suppressor gene p53 is mutated or deleted in about half of all cancers, it remains functional in the other half and could potentially be harnessed to suppress cancer's growth. Recent studies showed that the small molecule nutlin-3a can induce apoptosis in cancer cells by inhibiting the protein MDM2 from binding to and breaking down the p53 protein, but the effects of nutlin-3a on normal cells were not completely understood.
Now, researchers from NCI's Center for Cancer Research (CCR) and their Japanese colleagues report in the May 1 Cancer Research that nutlin-3a induces cell senescence (the inability to grow or divide) in normal cells by the activation of p53 and its associated cell-signaling pathways.
When the researchers treated normal human skin and lung fibroblast (connective tissue) cells with nutlin-3a, almost 100 percent of the cells underwent senescence, but in p53-deficient cell lines, nutlin-3a could neither increase p53 activity nor cause senescence. The investigators confirmed that a set of microRNAs involved in cell senescence were upregulated after the treatment: mir-34a, mir-34b, and mir-34c. In addition, many genes involved in DNA replication, chromatin remodeling, and gene expression, including ING2, were downregulated.
"We need to note the difference in effects of [nutlin-3a] between normal and cancer cells," explained CCR co-author Dr. Izumi Horikawa. "We knew nutlin-3 induced apoptosis in cancer cells. In this research, in normal cells, the major response to nutlin-3a was senescence. Apoptosis is an irreversible death, but cells in senescence are still alive and can be functional." Further preclinical studies are needed to see if nutlin-3a's ability to induce apoptosis in cancer cells and senescence in normal cells is therapeutically relevant and applicable to cancer, he concluded.
Long-Term Smoking Cessation Cuts Cancer, Mortality Risk
New data from the Nurses' Health Study confirm the lethal effect of long-term smoking and indicate that starting smoking at an earlier age increases the risk of death from cancers caused by smoking. However, the study also confirms that the risk of death from diseases caused by smoking, including lung cancer, heart disease, stroke, and respiratory disease, drops dramatically after sustained periods of cessation.
Overall, the analysis, published in the May 7 Journal of the American Medical Association, found that nearly two-thirds of deaths among current smokers were caused by cigarette smoking, compared with only 28 percent among former smokers.
The new data come from more than 20 years of follow up on approximately 104,000 women participating in this long-running observational study. A similar report in 1993 was based on 12 years of follow up. The new report includes an expanded array of disease endpoints. Current smokers had a 63 percent increased risk of colorectal cancer compared with people who had never smoked, but no significant increased risk of ovarian cancer.
"Smoking cessation was beneficial for each cause-specific mortality outcome examined," wrote the study's lead author, Dr. Stacey A. Kenfield, and her colleagues from the Harvard School of Public Health. For example, within 5 years of quitting, the risk of death from lung cancer decreased by 21 percent, while the risk of death from coronary heart disease decreased by 50 percent when compared with people who continued smoking.
Breast Cancer Stem Cells May Resist Chemotherapy
Some breast tumors may contain a subset of cells that not only drive the disease but also resist conventional chemotherapy, new research suggests. These cells, often called cancer stem cells, are defined in part by their ability to self-renew. To eradicate them, it may be necessary to combine chemotherapy with drugs that target pathways involved in self-renewal, according to results in the May 7 JNCI.
One such drug is lapatinib (Tykerb). This drug targets the HER2 and epidermal growth factor receptor proteins, which may contribute to self-renewal. Dr. Jenny Chang of Baylor College of Medicine and her colleagues found that cancer stem cells in breast tumors were unaffected by chemotherapy but may be sensitive to lapatinib.
Previous studies have reported that some breast cancer stem cells express the surface protein CD44 (but little or no CD24 protein), so the researchers examined this population of cells in tumor biopsies before, during, and after treatment. The study included 31 women who received chemotherapy and 21 who received chemotherapy plus lapatinib.
In the chemotherapy group, the proportion of cancer stem cells to other cells in the tumor increased, suggesting that chemotherapy had eradicated the bulk of tumor cells without affecting cancer stem cells. By contrast, in the lapatinib group, the proportion of cancer stem cells to other cells in the tumor remained basically the same. This indicates that the different cell types may have been eradicated with roughly the same frequency.
"The results are encouraging and suggest that inhibition of key regulatory pathways responsible for self-renewal could augment the effects of conventional therapy and improve clinical outcome," the researchers concluded.
The Future of Cancer Research: What's at Stake
When we speak about the future of cancer research, it's important to understand what's at stake, particularly given everything we have achieved over the past several decades.
When interacting with members of Congress, I often relay stories about individual cancer patients. One recent story is of a woman in her late 20s, with two young children, whose body and life had been dismantled by cutaneous T-cell lymphoma. Seemingly out of options, she came to NCI and the NIH Clinical Center. There she found "hope," in the form of the skill and dedication of NCI's Dr. Martin Gutierrez and an experimental drug being developed by NCI's Rapid Access to Intervention Development program, which has, for a year now, given her optimism for a longer, productive life.
That is what's at stake - individuals, sick patients, families.
As NCI's leadership continually assesses and attempts to manage a challenging budgetary scenario, we recognize that the extent of our progress is inextricably linked to our available resources. Yet we know that progress can and will continue. It will continue by supporting the young investigators who will build on today's remarkable discoveries; by ensuring that those discoveries can and do benefit all cancer patients, regardless of where they live or their socioeconomic status; by maintaining a vigorous intramural and extramural research program and helping to forge collaboration between academia, industry, government, and the nonprofit sector; and by driving the development of new technologies, tools, and resources that can hasten improvements while enhancing efficiency and cost effectiveness.
I always stress to legislators that, despite the challenges, our nation's investment in cancer research is paying great dividends - in lives saved, in a better quality of life, and in cancers prevented. I also emphasize the progress being made toward personalized therapy, and that a continued substantial investment in cancer research is necessary if we are going to realize our vision of therapies specifically designed to treat each individual's cancer in highly targeted ways. This investment - approximately $275 per person over the last 30 years - not only benefits cancer patients, but the advances cancer researchers are making in molecular biology, immunology, and genomics are impacting every disease.
And that's why we continue to push forward, despite the resource constraints we currently face. Because the cost of being content with the current state of affairs - as favorable as they have become for certain cancer types - is unacceptable.
And that cost extends beyond the many lives lost to cancer. According to the American Cancer Society's most recent estimate, the annual personal and financial cost of cancer in the United States is $206 billion. But our population is aging rapidly, and cancer is largely a disease of aging. As a result, NCI estimates that by 2017 - less than a decade from now - the total economic burden of cancer in the United States will be $1.82 trillion.
That's why we are working so diligently to place more emphasis on carefully reviewing and more aggressively funding new applications from young investigators; pursuing genome-wide association studies to identify small genetic and environmental factors that contribute to cancer risk; investing in subcellular imaging, in finding markers of disease before the disease is even measurable; investigating through the NCI Community Cancer Centers Program how best to educate, screen, and prevent cancer to make our discoveries readily accessible to people where they live. It's why we have pioneered phase 0 clinical trials to help make smarter decisions about which experimental agents to move into phase I and II trials, and why we have developed a program to help small businesses with promising new cancer interventions traverse the so-called "valley of death" to get those interventions into advanced clinical studies and to market.
What's at stake is clear. We have made tremendous gains and we must sustain and build upon them. Our future success depends upon a sustained commitment to research, so we can deliver on the promise of a world where stories about successful battles against cancer are the only ones to tell. Like the case of our patient with T-cell lymphoma, we need to be able to deliver hope and successful outcomes.
Dr. John E. Niederhuber
New Treatment Bubbles Up from Old Imaging Technology
Ultrasound has been a cancer-diagnosis workhorse for decades, bouncing high-frequency sound waves off of internal tissues and creating echoes that form pictures called sonograms. In the 1990s, researchers began studying the use of ultrasound for tumor ablation, harnessing the ability of sound waves to produce focused heat within the body. Now, they are combining advances in ultrasound technology with nanotechnology in a new category of experimental cancer therapies: microbubbles to facilitate drug delivery.
Microbubble-mediated ultrasound therapies are based on ultrasound contrast agents, which were developed to make it easier to differentiate target structure from surrounding tissue during imaging. Ultrasound contrast agents consist of a gas enclosed in a nanoscale lipid coating, called a microbubble, which is about 10 times smaller than the average human vascular cell.
When microbubbles are exposed to doses of ultrasound slightly longer than those used in imaging, the bubbles oscillate in a state called stable cavitation, expanding and contracting and exerting small forces on the tissue around them. With longer exposures, the bubbles collapse (called inertial cavitation), generating high shear stress, temperature, pressure, and shock waves in adjacent cells.
The therapeutic potential of cavitation quickly caught the eye of researchers working on ways to bypass the blood-brain barrier so chemotherapy drugs and other treatments can reach primary and metastatic brain tumors. The blood-brain barrier, a collection of tightly packed epithelial cells within the blood vessels leading to the brain, prevents most larger molecules - including therapeutic drugs - from passing from the bloodstream into the brain.
Researchers had tried to use ultrasound to temporarily open small portions of the blood-brain barrier, but obtained inconsistent results. They realized that microbubbles could be used to concentrate focused ultrasound energy on a precise tissue volume, sparing the surrounding brain tissue from exposure and minimizing damage to healthy cells.
"When we started to use the microbubbles [with ultrasound], we were able to get a reliable window…a blood-brain barrier 'opening' that was large enough to allow drugs through, and could be opened repeatedly," says Dr. Nathan McDannold, research director of the Therapeutic Ultrasound Laboratory at Brigham and Women's Hospital.
Interestingly, it's not clear how microbubble-mediated ultrasound actually causes the blood-brain barrier to open. "We don't think it's just a physical modification of the microvessels - we're not just poking holes in the blood vessels or stretching out the tight junctions," explains Dr. McDannold.
"It's probably related to the stable cavitation of the microbubbles," he continues.
Using electron microscopy, researchers have observed an increase in active transport of drugs across the blood-brain barrier after microbubble-mediated ultrasound, as if in response to physical stimulation from the oscillation.
So far, in animal models, this strategy has successfully delivered chemotherapy and trastuzumab (Herceptin) through small, temporary disruptions in the blood-brain barrier. These disruptions are self-healing, closing most of the way in several hours and completely in less than a week.
In a related area, researchers are looking at the use of inertial cavitation for targeted drug delivery. By loading drugs into the microbubbles or attaching them to their surface, researchers create delivery vehicles that can be injected into the bloodstream and triggered to release their cargo when they are hit by focused ultrasound at precisely the right time and in the correct location.
"Some drugs might have positive effects in one location, and harmful effects in others. If you localize them precisely, you might be able to maximize the dose and avoid the harmful effects," says Dr. Kullervo Hynynen, director of imaging research at Sunnybrook Health Sciences Centre and professor of medical biophysics at the University of Toronto.
An added benefit of this technique, explains Dr. Chrit Moonen, director of the Laboratory for Molecular and Functional Imaging at the Université Victor Segalen Bordeaux 2, is that when the microbubbles collapse and release their payload, the adjacent blood vessels and cell membranes become more permeable from the forces of cavitation, enhancing absorption of the drug.
Before it can be tested in humans, microbubble-mediated ultrasound therapy requires additional safety data. Of particular concern are the consequences of multiple rounds of treatment, whether potential damage to local tissue could be prevented by real-time MRI monitoring, and the effects of high initial concentrations of drugs delivered to a small area of tissue. In vivo studies to address these concerns are currently underway at academic centers around the world.
—Sharon Reynolds
These projects and other ultrasound research were presented at the first annual NIH-sponsored Image-Guided Interventions Workshop, held March 10 and 11 of 2008 in Rockville, Maryland.
Senate Hearing Focuses on Cancer Research Challenges
On May 8, a panel of cancer survivors, advocates, and researchers testified before the U.S. Senate Committee on Health, Education, Labor, and Pensions at a hearing on cancer. The topics discussed included prevention, access to health care, insurance coverage, and cancer research.
The legislators and panelists called for greater emphasis on prevention and early detection and increased access to health care. Mr. Case stressed the need for greater innovation in cancer research and more interagency and public-private collaborations. He also suggested that a computer industry-like approach may reinvigorate current biomedical research strategies that have stalled. Ms. Moddelmog and several other panelists urged the committee to mandate health insurance coverage for clinical trials to increase participation.
Committee Chairman Senator Edward Kennedy (D-MA) announced his intention to introduce legislation, co-sponsored by Senator Kay Bailey Hutchison (R-TX), encouraging a comprehensive approach to cancer research, rather than placing an emphasis on one or more types of cancer. Dr. Benz concurred, saying he favors studying molecular signatures and other biological identifiers of cancers rather than continuing to focus on cancers in specific organ sites.
An archived webcast of the hearing can be found at http://help.senate.gov/Hearings/2008_05_08/2008_05_08.html.
Progression-free Survival: Patient Benefit or Lower Standard?
The U.S. Food and Drug Administration (FDA) recently granted bevacizumab (Avastin) accelerated approval for use in combination with paclitaxel (Taxol) to treat some patients with metastatic breast cancer. The decision cast a spotlight on a somewhat controversial clinical trial endpoint that the agency used to support its decision. Though the combined therapy improved progression-free survival (PFS) by 5 months compared with the control group, which received only paclitaxel, there was no significant improvement in patients' overall survival (OS).
The difference between PFS and OS is that PFS measures the time from a patient's random assignment to one treatment arm or another until the patient's cancer begins to grow again or the patient dies from their cancer; whereas OS measures the time from randomization until death from any cause.
Central to the controversy over the use of PFS as an endpoint in cancer clinical trials is whether delaying disease progression matters if a cancer treatment doesn't also lengthen patients' lives. Put another way, which matters more: longer life or better quality of life?
FDA considers OS the most reliable cancer endpoint. It is a universally accepted direct measure of the benefit of an experimental drug or other treatment, and it is unequivocal and easy to measure. Demonstrating in a clinical trial that a drug improves OS, however, is no easy feat. It often requires trials with hundreds of patients that take years to complete.
Furthermore, with multiple treatment options now available for many types of cancer, patients can switch to other therapies if the treatment they are receiving in a clinical trial stops working. That's good for patients, but it creates a conundrum for those who must interpret trial results: If a patient's OS improved, how much of that improvement was due to the study drug and how much was due to subsequent treatments?
In this respect, explains Dr. Daniel J. Sargent, a biostatistician with the North Central Cancer Treatment Group (an NCI-sponsored clinical trials cooperative group) who has authored numerous articles about endpoints in cancer clinical trials, PFS offers an advantage over OS because it requires patients to be followed only until their disease progresses. PFS, therefore, measures only the effect of the study drug and is not diluted by subsequent treatments patients receive, as OS may be.
"Most patients stop taking the study drug when their disease begins to progress," he says, "so the PFS clock stops at that point." This also means that trials using PFS as an endpoint can be completed more quickly than trials using OS, and they generally require fewer patients.
A key advantage of PFS as a clinical trial endpoint, says Dr. Sargent, is that "it captures both a tumor-shrinkage and a tumor-stabilization effect." This is important because, unlike conventional chemotherapeutic drugs that kill cancer cells, causing tumors to shrink, many new targeted drugs (including bevacizumab) work by other mechanisms, which may stop tumors from growing but don't always cause them to shrink.
A concern with using PFS as a trial endpoint, says Dr. Sargent, is that it's more subjective than OS and can be influenced by outside factors, including how disease progression is defined and measured, which may vary from one trial to another. For example, because progression is measured by X-rays or computerized tomography (CT) scans, measures of PFS can differ depending on how frequently those assessments are performed.
Other questions surrounding PFS include: What magnitude of improvement in PFS is clinically meaningful? And is an improvement in PFS beneficial to patients in and of itself, regardless of whether OS is also improved?
Dr. Jo Anne Zujewski, head of Breast Cancer Therapeutics in NCI's Division of Cancer Treatment and Diagnosis, is emphatic that, at least in advanced breast cancer, an improvement in PFS is beneficial to patients in and of itself. "In advanced breast cancer, disease progression is often symptomatic and uncomfortable, so if we can delay that, it's a benefit to the patient," she says.
However, Dr. Zujewski adds two caveats: "The magnitude of the benefit must be sufficient to be confident that it's not biased. An increase of a month or two would not provide that confidence and would probably not be clinically meaningful. Second, patients must not endure a lot of toxicity as a price for keeping their disease in control longer. If an oral agent had very few side effects and delayed progression for 4 months, most patients with advanced breast cancer would take it."
Dr. Richard Pazdur, director of the FDA Office of Oncology Drug Products, agrees. "I have no problem accepting that, in a lethal disease such as metastatic cancer, delaying progression is a clinical benefit in itself, provided that the magnitude of the benefit is sufficient and the side-effect profile acceptable."
FDA has recently approved several other new anticancer drugs based on an improvement in PFS, notes Dr. Pazdur, including sorafenib (Nexavar) for renal cell cancer, gemcitabine (Gemzar) for ovarian cancer, and ixabepilone (Ixempra) for breast cancer.
The agency still asks clinical trial sponsors to enroll a sufficient number of patients to detect an effect on OS, adds Dr. Pazdur. "We always want to be sure a drug isn't reducing OS," he explains. "But a dogmatic approach that we will accept only an improvement in OS for drug approval doesn't serve anyone well, certainly not patients. I know there are people who think granting approvals based on an improvement in PFS amounts to lowering the standard, but I view it as having greater flexibility."
—Eleanor Mayfield
Adjuvant Aromatase Inhibitor Therapy for Breast Cancer
Name of the Trial
Principal Investigators
Why This Trial Is Important
Anastrozole (Arimidex) and exemestane (Aromasin) are two AIs approved by the FDA to treat early-stage, hormone receptor-positive breast cancer. Anastrozole is a reversible inhibitor that competes with estrogen precursor molecules for binding to aromatase; exemestane attaches permanently to aromatase, preventing estrogen precursors from binding to the enzyme at all (making it an irreversible "suicide" inhibitor). Exemestane also exerts androgenic (male hormone-like) effects in women, and this may contribute to its anticancer efficacy while possibly causing fewer side effects.
In this clinical trial, postmenopausal women with hormone receptor-positive breast cancer that has been surgically removed will be randomly assigned to receive either anastrozole or exemestane for 5 years. Doctors will monitor breast cancer recurrence and the side effects of these drugs. Separate companion studies will examine whether there is a difference in how the drugs affect bone mineral density and breast density in these patients; only those locations enrolling patients in the breast density companion study (NCCTG-N0434) are currently accepting patients for the AI study.
"While anastrozole and exemestane have not been compared previously in a clinical trial, evidence from preclinical studies and other clinical trials comparing each agent to tamoxifen support the idea that exemestane may be a more potent inhibitor of aromatase and have androgenic effects that may be important in enhancing efficacy and affording a better side effect profile," Dr. Goss said.
For More Information
An archive of "Featured Clinical Trial" columns is available at http://www.cancer.gov/clinicaltrials/ft-all-featured-trials.
Oberholtzer and Mackall Named CCR Chiefs
Dr. Crystal Mackall has been appointed the chief of CCR's Pediatric Oncology Branch. She has served as acting chief since August 2005. Dr. Mackall is an international leader in pediatric oncology translational research, with a primary focus on development of effective immune response therapies for pediatric cancer and immune reconstitution.
NIH has issued a Request for Information (RFI) seeking input from the scientific community, health professionals, patient advocates, and the general public on innovative and cross-cutting initiatives to be supported through the Common Fund as part of the NIH Roadmap for Medical Research. Responses will be accepted through June 2, 2008.
The Common Fund/NIH Roadmap supports trans-NIH programs that address gaps in fundamental knowledge, develop transformative tools and technologies, and foster innovative approaches to complex problems. The Roadmap programs are expected to have exceptionally high impact and transform the way research is conducted. This collection of ideas is an initial step in the process of identifying a new cohort of NIH Roadmap programs for fiscal year 2011.
PLCO EEMS Seeks Applicants
PLCO data and biospecimens are available to qualified researchers through a peer review process. The EEMS program accepts proposals for access to PLCO biospecimens twice a year in June and December. Proposals will be accepted for the EEMS summer review cycle starting June 1, 2008. Applications will be accepted until June 30, 2008, at 5:00 p.m. ET. Details of the review process and application materials are available at http://www.parplco.org. Questions may be directed to firstname.lastname@example.com or 240-314-5896.
PHS Releases New Tobacco Cessation Guidelines
The resource, co-authored by Dr. Glen Morgan of NCI's Tobacco Control Research Branch, includes information about new medications, advances in counseling methods, and treatments that are proven to be effective for adolescent smokers. Of particular note are findings that counseling significantly improves the effectiveness of tobacco cessation medications, that quitline counseling is effective and broad reaching, and that counseling increases abstinence from smoking among adolescents.
The updated resource can be accessed online at http://www.surgeongeneral.gov/tobacco/default.htm and copies can be ordered through the national tobacco quitline, 1-800-QUIT-NOW (1-800-784-8669), which connects people with their local, state-based quitline service.
Following are newly released NCI research funding opportunities:
Transdisciplinary Research on Fatigue and Fatigability in Aging
Application Receipt Date/Dates: Non-AIDS Applications (new): June 5, Oct. 5, 2008; Feb. 5, June 5, and Oct. 5, 2009; Feb. 5, June 5, and Oct. 5, 2010; Feb. 5, 2011
This funding opportunity will use the R01 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3881. Inquiries: Dr. Ann M. O'Mara - email@example.com.
Community Clinical Oncology Program
Letter of Intent Receipt Date: June 10, 2008
This is a renewal of RFA-CA-07-048 and will use the U10 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3879. Inquiries: Dr. Lori Minasian - email@example.com.
Minority-Based Community Clinical Oncology Program
Letter of Intent Receipt Date: June 10, 2008
This is a renewal of RFA-CA-07-049 and will use the U10 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3880. Inquiries: Dr. Worta McCaskill-Stevens - firstname.lastname@example.com.
Transdisciplinary Research on Fatigue and Fatigability in Aging
Application Receipt Dates: Non-AIDS Applications (new): June 16, Oct. 16, 2008; Feb. 16, June 16, and Oct. 16, 2009; Feb. 16, June 16, and Oct. 16, 2010; Feb. 16, 2011
This funding opportunity will use the R21 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3881. Inquiries: Dr. Ann M. O'Mara - firstname.lastname@example.com.
Stem Cells and Cancer
Application Receipt Date/Dates: Non-AIDS Applications (new): June 16, Oct. 16, 2008; Feb. 16, June 16, and Oct. 16, 2009; Feb. 16, June 16, and Oct. 16, 2010; Feb. 16, 2011
This is a renewal of PA-06-282 and will use the R21 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3883. Inquiries: R. Allan Mufson - firstname.lastname@example.com.
CECCRs Share Results and Lessons
Every week, new information about cancer is published in scientific journals. But the impact of that research falls short without methods of sharing it in a way that actually changes behavior to reduce risk, improve screening, and create access to treatments.
This is why NCI funded the Centers of Excellence in Cancer Communications Research (CECCR) in 2003. The initiative provided four university-based research centers with $10 million each over 5 years to test effective strategies for cancer communications and translate them into tools for practice.
The key to the centers, explains Dr. Bradford Hesse, who oversees the initiative and is chief of the Health Communications and Informatics Research Branch in NCI's Division of Cancer Control and Population Sciences, has been a transdisciplinary approach.
"The CECCRs brought communication scientists, often for the first time, into direct contact with oncologists; they put computer scientists in touch with health educators; and they allowed statisticians to work in tandem with health behavior theorists," Dr. Hesse says. "The whole purpose was to create a synergistic environment for innovation."
At the end of last month, CECCR grantees came together in Atlanta to showcase their research results to stakeholders in cancer communications from within the government and the advocacy community.
Attendees learned about tools developed by the CECCR at the University of Michigan, led by Dr. Victor Strecher, which focused on three main research studies. One project, for example, analyzed Web-based smoking cessation programs.
The University of Pennsylvania CECCR, led by Dr. Robert Hornik, focused on ways to improve public information campaigns in three projects, including one that looked at ways in which people search for cancer information.
Under Dr. Matthew Kreuter, Saint Louis University's CECCR focused three projects on cancer communications for African Americans. One of these projects tested 80 videotaped "Living Proof" testimonies from African American breast cancer survivors as a way to encourage women to get mammograms.
And at the University of Wisconsin, Dr. David Gustafson has led a center that developed computer tools to help with all aspects of a cancer diagnosis. One of these three projects evaluated whether CHESS, an interactive communication system, improved palliative care and communication between patients and their clinicians.
The CECCR initiative has not only produced new tools and peer-reviewed literature; it has sparked institutional changes. At the University of Pennsylvania, for example, 34 graduate and 14 post-graduate scholars have trained or are being trained at the CECCR and 19 have already gone on to obtain positions in the fields of public health and communications research. The center has also stimulated a shift toward research on cancer among several leading scholars at the university's Annenberg School for Communication.
The University of Wisconsin's CECCR has created very exciting opportunities for cross-departmental collaboration, says Dr. Gustafson, pointing to partnerships between the School of Pharmacy and the departments of Radiology and Computer Science as examples. "We are working much more closely than ever before with the Transdisciplinary Tobacco Use Research Center here and the Department of Psychology in particular," he adds.
There have been similar changes at the University of Michigan, notes Dr. Strecher. "An important legacy of the initiative is our open-source Michigan Tailoring System software and the weeklong Michigan Tailoring Workshop, which provides tools and training that will prepare the next generation of health communications researchers," he says.
These are exactly the kind of changes that were hoped for when the CECCR initiative began, says Dr. Hesse. Even so, "We need to solve the 'last mile problem' - that is, getting our evidence-based communications applications out of the laboratory and into the public domain."
The recent meeting in Atlanta was one step toward this goal; the next will come later this year through a second round of CECCR funding, which will have greater emphasis on projects with clinical relevance for patients across the cancer care continuum.
—Brittany Moya del Pino


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24/7 Wall Street insists that the BlackBerry brand is at death's door. However, it predicted the same thing in 2012.
The FutureBrand Top 100 Index asks "informed consumers" to rate brands. Google comes first. Apple is beaten even by Microsoft.
A study of 5,804 brand Facebook pages and 1,578,006 total posts offers some fascinating conclusions. Sixty-seven percent of posts are at a 5th grade reading level or below.
Apple's brand value fell by 20 percent, according to a survey by Millward Brown research company.
The telecom giant re-introduces the new Cricket service with some competitive offers.
Former Nokia CEO Stephen Elop, now head of Microsoft's devices group, shares his thoughts on the future of smartphones and the promise of a transcendent "colorful personality."
An icy object causing a commotion in Saturn's rings may give astronomers insight into how Saturn's moons form.
The airline says a pornographic image sent to a customer from its Twitter account was actually sent to it by someone else. Is this entirely believable?
The Samsung Galaxy S5 hits shops Friday, and Samsung has opened more branded stores today to celebrate the new phone.
Jamie Hewlett and Alan Martin have taken to Kickstarter for a brand-new, 100-page Tank Girl hardcover also featuring the work of six other brilliant indie artists.


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