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Zombie-American Chapter One from Ed Helms

Zombie-American Chapter One
Ed Helms
Starring Ed Helms
Published May 04, 2007
430k views
More Info »
Full Credits
Ed Helms
Stats & Data
4,417 Funny Votes
823 Die Votes
430,938 Views
Published May 04, 2007
Web Series
Chapter One
Ed Helms
Funny video
The video opens with a shot of feet moving down a sidewalk. There is
litter being dragged beneath the feet as the move in shuffle, rathe
than a stride.
Ed Helms (voiceover)
: I was mad at first, yeah. I was mad as hell. But, now, I really take pride in it…
The shot pans up to reveal Ed Helms walking down a city street. His
face is in makeup that makes him appear to be one of the walking dead.
Ed Helms (voiceover)
: …and I see I see it as sort of my mission to get the message out there…
The shot cuts to an interior setting with a headshot of Ed Helms.
Ed Helms
: …that we're not, not so bad.
Folksy guitar music begins to play and the shot goes black. The words
–Zombie-American – appears on the screen, fades out, and is replaced by
the words – Chapter 1. The shot cuts back to the interior setting.
Ed Helms
: My name is Glen and I'm a zombie.
The shot cuts back to an exterior shot of Ed Helms walking down the street.
Ed Helms (voiceover)
: I choose to present myself as a zombie who wants to get…
The shot cuts back to the interior setting.
Ed Helms
: an image of zombies out there that's a little different from the conventional zombie stereotype.
The shot cuts to Ed Helms walking down the street again. Two random
strangers coming out of doorway hail Ed Helms in a friendly way.
Ed Helms (voiceover)
: I like to sort of stay away from what a zombie is…
The shot cuts back to the interior setting.
Ed Helms
: …technically, because that sort of makes up seem freakish.
The shot cuts back to Ed Helms walking down the street.
Ed Helms (voiceover)
: The thing that most people know, which is true, is that we are walking dead.
The shot cuts back to the interior setting.
Ed Helms
: What most people don't realize is that we do a lot of things besides just walk.
The shot cuts to Ed Helms reading a book with Bill Clinton's face on the cover.
Ed Helms (voiceover)
: I like to curl up with a good book. (non-voiceover) Ha, ha, ha, ha. What a cad.
The shot cuts back to the interior setting.
Ed Helms
: I like, you know, to do the crossword puzzle.
The shot cuts to Ed Helms doing a crossword.
Ed Helms (voiceover)
: And, I'm not going to lie to you, the only thing
I enjoy more than doing the crossword puzzle, is finishing it.
The shot cuts back to the interior setting.
Ed Helms
: One way that I like to chill out, calm myself down, is to play my guitar.
Ed Helms picks up a guitar and plays briefly.
Ed Helms
: Play a little bit of music.
The shot cuts to Ed Helms walking down a street.
Ed Helms (voiceover)
: I really like helping people. (non-voiceover,
speaking to a passerby) You guys lost. (voiceover) It's something I
like to do, make people feel good about themselves. (non-voiceover,
looking at a map) This way. To the bridge, yeah, it's this way (points).
: Thank you.
Ed Helms
: You're welcome. Take care.
The shot cuts to Ed Helms sitting on the front steps of a building.
Ed Helms (voiceover)
: It's a rough road being a zombie. There's a lot of anti-zombie sentiment out there.
The shot cuts to Ed Helms walking down the street with his arm held out at a bizarre angle.
Ed Helms (voiceover)
: People think that zombies walk funny.
The shot cuts to the interior setting.
Ed Helms
: Well, we do walk a little bit unusual.
The shot cuts back to Ed Helms out on the sidewalk, banging his arm against a fence.
Ed Helms (voiceover)
: It has to do with joint decay, cartilage decay, tendon decay.
The shot cuts back to the interior setting.
Ed Helms
: Another stereotype that's out there is that all we eat are
brains. Ha, ha, you know. Bullshit. I like a ham sandwich now and then.
The shot cuts to Ed Helms in the bathroom brushing his hair.
Ed Helms (voiceover)
: A lot of people just assume that because you're a zombie, you're grotesque looking.
The shot cuts back to the interior setting.
Ed Helms
: I'll admit, I'm not Fabio, but I think I'm pretty put together, a pretty handsome guy.
The shot cuts back to Ed Helms in the bathroom.
Ed Helms
: Gotta look good. Gotta look my best.
Ed Helms cleans some of the sore on his face with a Q-tip. At one point, he passes the Q-tip into one sore and out of another.
Ed Helms
: Oh, there it is. Ha, ha. Can your friend do that? I don't
think so. That's good stuff. That's a great party trick too.
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text:
Are you enjoying the football and basketball seasons?
Kids across the country sure are! You can be an ALL-STAR parent without missing even one of the season's big games! And we don't just mean you'll be playing and watching and cheering, but you'll be reading the best books about sports out there.
PatchReads and ReadKiddoRead want to get you and your kids talking about some great sports books with the Tailgate Book Club. Follow these steps to make the most of pre-game time, halftime, and all the days in between.
Step 1: Pick a book each week based on the ReadKiddoRead Tailgate Book Club List, and have all your friends and their kids read it before game day.
Step 2: Gather everyone together for the game. During half-time, put the TV on mute and dive into your Tailgate Book Club by filling in the blanks on our get-talking sheets. You can find these at ReadKiddoRead.com. Print copies for everyone! (You can also print out trading cards for each book. Print enough so that everyone who has read the book can have one. They'll want to collect them all.)
Here's a recommended list of books to get you started!
Great Picture Books - For ages 2-6
"Spot Loves Sports by Eric Hill" (ages 1-4)
The youngest kids in the family can participate in your halftime book club. Spot, an enduring favorite character of kids who crawl and toddle, goes to the park to race, play soccer, and have an altogether thirsty-making and fun-filled day in his latest board-book adventure.
"Tyrannosaurus Dad" by Liz Rosenberg; illustrated by Matthew Myers (ages 4-6)
Tobias's dad, like so many dads, is always busy, always working. (Unlike most dads though, Tobias's father happens to be a Tyrannosaurus.) Tobias tries everything he can think of to get his father to come to his school's Field Day. Dad finally shows up and steps in as the umpire in a baseball dispute. Now who's going to argue with a dinosaur?
Great Beginner Reads - For ages 6-9
"Teammates" by Peter Golenbock; illustrated by Paul Bacon (ages 6-9)
It took a kind of courage that few of today's kids can imagine for Jackie Robinson to step onto the baseball field as a Brooklyn Dodger in 1947. It also took courage for one of his teammates, Pee Wee Reese, to step up, put his arm around Robinson and talk – right there, in front of the crowd. This event is captured in the simple words, drawings and old photos of this picture book.
"You Never Heard of Willie Mays?" by Jonah Winter; illustrated by Terry Widener (ages 7-9)
Not only does this non-fiction picture book tell all about Willie Mays and his astonishing baseball career, it's as much fun to read as watching a game. As a boy, Willie idolized Joe DiMaggio; as a teen, he copied Joe's style, and as a young man he brought that style and his talent to the New York Giants, which had just been integrated. With play-by-play descriptions and action-filled illustrations, this biography gives new independent readers lots to contribute to sports book talk at halftime.
And check out:
"You Never Heard of Sandy Koufax?!" by Jonah Winter; illustrated by Andrew Carriho (ages 7-10)
"There Goes Ted Williams: The Greatest Hitter Who Ever Lived" by Matt Tavares (ages 7-11)
We know that baseball is more than a game. It is the stuff of legend. This biography focuses on Ted's childhood and his early dedication to practice, practice, practice. And it paid off in his record-breaking career. He is a sports hero we can continue to admire, and with this engaging picture book, a new generation will know his story and profit from his example.
And check out:
"Henry Aaron's Dream" by Matt Tavares (ages 7-10)
Great Pageturners - for ages 9-12
"Baseball Saved Us by Ken Mochizuki"; illustrated by Dom Lee (ages 8 and up)
Shorty and his father build a baseball field and create teams while they are in a Japanese-American internment camp during World War II. The games do more than help pass the time; they lift spirits and self-respect and offer reasons for hope.
"Hey Batta Batta Swing!: The Wild Old Days of Baseball by James Charlton and Sally Cook," Illustrated by Ross MacDonald (ages 8 and up)
What was the game of baseball like when it began more than a century ago? Back then, you could get a runner out by soaking him. Soaking? It was "a very early rule that allowed a runner who was off base to be put out by hitting him with a ball." Ouch. This entertaining array of baseball facts will surprise even the biggest baseball fans.
"Hope Solo: My Story" by Hope Solo (for ages 8 and up)
She's a soccer sensation; the starting goalkeeper for the U.S. women's national soccer team and an Olympic gold medalist. And with this book, adapted from her adult "Memoir of Hope," she will be an inspiration for young athletes.
"The Underdogs" by Mike Lupica (ages 8-12)
From the title and vivid cover, readers may guess that this is a book about a determined team of middle school football players struggling to beat odds stacked high against them. Of course, they're right, but there's a lot more to this story. It is also about their hometown facing a serious recession when the local sneaker factory closes under the pressure of bigger companies. How Will Tyler, captain of the Bulldogs, helps his team, his out-of-work father, and the whole town makes for a novel that is a touchdown!
And check out:
"Game Changers" by Mike Lupica (ages 8-12)
Great Advanced Reads - For ages 12 and up
"True Legend" by Mike Lupica (ages 11-14)
Fifteen-year-old high school basketball star Drew Robinson faces a tough decision: should he take an opportunity to switch schools and play for a ritzy private school (where he's sure to get all sorts of special treatment)? Drew makes the switch and begins to enjoy his new status, but soon his game begins to suffer. Told with the clear voice and honesty of sportswriter Mike Lupica, this novel has plenty of sports choices along with a hard-earned lesson.
"The Final Four" by Paul Volponi (ages 12 up)
Teens get right inside a game in the semifinal round of the NCAA men's basketball championship, as they get to know two players on each of the competing teams: The Michigan Spartans and the Troy Trojans. Newspaper articles, interviews, journals, and flashbacks interspersed with game action, reveal Michael, Malcolm, Roko and Crispin's backstories, motivations and aspirations and show how their different backgrounds and their individual problems shape them. The characters are real, multi-faceted, and set on winning.
And check out:
"Crossing Lines" by Paul Volponi (ages 12 up)
"The Moves Make the Man" by Bruce Brooks (ages 12 and up)
The basketball story—with game scenes wonderfully described— is wrapped around a story of friendship and coming of age. Jerome Foxworthy's got the moves – on the court and off. And he's cool, despite some tough breaks. – he's sure of that. Still, for some reason he doesn't quite understand, he's decided to teach Bix Rivers, a mentally-challenged kid at school, how to play the basketball. Maybe it will help Bix cope with all the troubles he's got. Basketball has always been good for what ails Jerome.
"Game Changer "by Margaret Peterson Haddix (ages 12 up)
In a novel that combines sports story, mystery, and fantasy, KT, a softball star, blacks out during a game and wakes up in a different world. In KT's new reality only academic success is admired – not athletic or other talents. As she struggles to understand this world, KT questions everything, especially the values in the life she led, where kids had to define themselves by predetermined categories: good student? jock? gamer? The lines were clear – and now KT sees, limiting. There is much to think about and talk about in this involving take on sports.
"The Contender" by Robert Lipsyte (ages 13 and up)
This long-lived classic young adult novel, about a 17-year-old high-school dropout from Harlem, is as powerful today as it was when it was first published. Alfred Brooks's dead-end job, the gang of kids who are after him, and his friend's spiral down the road of drug addiction leaves him in need of hope. He finds it at a gym where he discovers not just his talent for boxing, but also lessons about hard work and determination.
Every fan loves to know stats and talk about them. These books will get you started.
- "NFL Record and Fact Book 2012" by Editors at the NFL
- "Great Baseball Feats, Facts and Firsts" by David Nemec, et. al.
- "Sports Illustrated Almanac 2012" by Editors of Sports Illustrated
- "NHL Official Guide and Record Book 2012" by the National Hockey League

subset: commoncrawl


text:
Kimmel does this every year and it's awesome! Can't believe the way some of these kids talk to there parents. And some of them seem like such sweet kids. The little girl who is going to finish eating her cereal is my favorite. The beauty of this is I can enjoy this video without having kids myself!
But here's an even better reason not to have kids>>


text:
Christmas Wreath Wall Hanging
Two sisters whom help us out a great deal at The Calico Horse designed this pattern. They love working with Moda Charms and are always creating new and fun designs. The sisters had such fun with this wreath we wanted to share it. This is the first time our shop The Calico Horse has been on Moda Bake Shop and we feel quite honored.
2 charm packs of Makin" New Friends by Moda
1/3 yard for binding
3/4 yard for backing
Rotary Cutter, and Ruler
Separate charms into 3 piles: blues and greens, reds, and lights.
Cut 27 light charms into 108 - 2" squares
Cut 33 blue and green charms into a total of 132 - 2" squares.
Choose 2 red charms for bow and trim into 3 1/2" squares.
Choose 4 red charms for corners and trim into 3 1/2" squares.
Cut remaining red charms into 14 - 2" squares.
To make bow choose two light 2" squares and two dark 2" squares and trim them down to 1 1/2" squares.
Draw a diagonal line on the wrong side of each. Place 1 1/2" blocks on 3 1/2" red square as shown and sew on diagonal line. Press to corner and trim back to 1/4" seam allowance.
Piece quilt as shown in diagram. Quilt and bind using your favorite method.
Finished Size 24 X 24, Perfect Christmas Wall Hanging
The Calico Horse Shop
The Calico Horse Blog
16 comments:
- Sipiweske Quilts said...
What a great Christmas project! I know I have some fabric that will work perfectly for this - never too soon to start thinking about Christmas gifts/projects. Thanks a bunch!
- May 25, 2010 at 11:21 AM
- traceyjay said...
I like these kinds of Christmas quilts... with the trees and wreaths. Very cute. :)
- May 25, 2010 at 1:01 PM
- Michelle said...
- May 25, 2010 at 1:53 PM
- caknitter said...
Wow, that is beautiful christmas wreath quilt.
- May 25, 2010 at 4:00 PM
- Connie said...
WOW! This is a beauty using squares. Love it.
- May 26, 2010 at 12:34 AM
- Maria said...
Just love it.
- May 26, 2010 at 3:42 AM
- mainer said...
Great project!
- May 26, 2010 at 10:29 AM
- joan said...
Absolutely gorgeous! Now I know what I will be working on this week-end I just finished the Garden Charm table topper by Marlene Biles and I love it!
- May 26, 2010 at 7:24 PM
- Joanna said...
I love this quilt. This may sound nutty, but I have been looking for a Christmas project using Christmas fabric, and I think this may be it.
- May 30, 2010 at 9:49 PM
- cindy said...
As a first time quilter I am quite impressed.
Do you have tips that could help me out. I'm having trouble taking my time. I always rush!
- June 2, 2010 at 7:45 PM
- Trisha said...
for sure this really takes time to make! amazing! really nice! :D
- June 13, 2010 at 2:36 PM
- Pauline M said...
I'm the one that's nutty. Don't like waste and don't like wasting time. Why not just cut the charms in half each way, making 2 1/2" unfinished postage stamp pieces?
The quilt will come out to 30" which is still a nice sized, easy to handle, WH.
- December 22, 2010 at 12:03 PM
- Simplesmente Silvinha said...
Beautiful , I love .
- December 6, 2011 at 6:46 AM
- Karen said...
I had fun making this wreath. Thank you for the great idea.
Here is a link to my wreath.
Wreath Quilt
- January 20, 2012 at 10:13 PM
- Karen McCorkle said...
So cute. Thanks for sharing!
- November 3, 2012 at 9:45 PM
- Lin said...
I'm with Pauline - it would be so much easier,faster and a lot less waste.
- February 1, 2014 at 8:59 PM


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29 U.S. Code § 1506 - Transferred
Section, Pub. L. 101–649, title VIII, § 801,Nov. 29, 1990, 104 Stat. 5087, which related to educational assistance and training, was transferred to section 2920 of this title.
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
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text:
Electronic music, marble tile floor, black and white stenciled walls and table tennis -- a new club dedicated to the sport of ping pong is open for business in downtown Detroit.
"We kind of infuse the game of table tennis, ping pong as some might say, with the social dynamics of music, fun, entertainment, design, elegance and put all that together. What you have is Drive Table Tennis Social Club," explained owner Diallo Smith.
Smith and his wife opened up Drive with a hope to change the way people think about ping pong.
"We wanted to wrap the game of ping pong around some glamour, some elegance, kind of take it out of the rec rooms," said Smith.
It's fun. It's flashy. It's somewhere to hang with your friends. It's also a place the best of the best come to play.
Paul and Danny play in tournaments across the country and hone their skills during league night at Drive.
"I've been playing ever since they opened. I was at the grand opening, and me and my friend Paul have been coming here and playing league nights every Wednesday," said Danny Dulkin. "There's good competition. You get to come play and get good exercise."
The best part about Drive is you don't have to be good.
"We have all kinds of people. We have the serious, Forrest Gump players that come and they're battling out, expert players. We have leagues. We have tournaments. But we accommodate the people who want to learn. We offer training sessions," Smith said.
So whether you're looking to train or just hang out, you can find more information about Drive at www.drive-detroit.com.
KTTV FOX 111999 S. Bundy Dr.Los Angeles CA 90025Main: (310) 584-2000News Tips? (310) 584-2025


text: Hayground School Farm Stand Comment | August 1, 2012 | By Brian Halweil Hungry for More Edible?SIGN UP FOR OUR NEWSLETTER TO KEEP UP WITH STORIES, EVENTS & MORE* About Brian Halweil Brian is the editor of Edible East End, and co-publisher of Edible Long Island, Edible Manhattan, and Edible Brooklyn. He writes from his home in Sag Harbor, New York, where he and his family tend a home garden and orchard, and keep ducks and oysters. All Posts By Brian Halweil Follow Brian Halweil on: twitter, instagram Categories


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You're Supposed to Be Quiet in Libraries...But for THIS I'll Make an Exception! - @luvgospel
00:04:45 2960 views
Press the button below if you liked this video! Thank you! =D
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Posted By luvgospel 2011-05-06T11:49:33
To all the mutha's out there! Christian comedian Anita Renfroe is back with a new salute to moms -- in Tha Muthahood! Slightly updated from William Tell Overture. Share this with a mom you love to remind them how much you appreciate them!
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text:
Cafe Sevilla- Long Beach
Online Reservations
Our mezzanine is upstairs, a more intimate setting than our tapas bar, keeping the lively energy from our tapas bar entertainment!
This is our larger, semi private room that can still feed off of the energy from the bar and tapas entertainment.
This is our fully private, large venue space for parties of 200 seated. We can provide, lighting, equipment, DJ, flamenco dancers, live entertainment.


text:
Personalized Initial Favor Boxes Pack of 50 Style DBK61MP
Lowest Price Per Unit: $0.60
Final sale. This item cannot be exchanged or returned.
This item is available online only. *
Create personal wedding favors with classic style by packaging treats in these favor boxes. Personalize with a single script initial and two lines of personalization in your choice of foil color. For example, bride and groom's names on one line and wedding date on second line. Personalization will allow for up to 25 characters per line including spaces. Enter your event date in the following format - date spelled out (month, day, year).
Note: Candy not included
Wrapped candies or liners are recommended when placing food in favor boxes.
customers bought with this dress
Personalized Initial Favor Boxes Pack of 50 Style DBK61MP 0 2
1-2 of 2
*Color & Style representation may vary by monitor. Not responsible for typographical or pictorial errors. Product availability varies by store and online. Some in-store purchases require special order and markdown styles cannot be special ordered. Contact your local store for details.


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text:
Angel Governing Jan 16th to 20th
Angel number 60 - ANGEL MITZRAEL - Energy: DIVINE RESTORATION
Qualities: Rectification - Facilitates psychology and psychiatry - Cures mental illness - Mastery of emotions and passions - Understanding of obedience and authority - Fidelity to Divine Self - High moral standards - Repairs damage caused by wrong desires - Restoration through awareness - Unites qualities of the soul and the body - Simplicity - Good for exams .
Distortions - Insubordinate - Persecution - Infighting - Everyone for himself - Revolt - Mental illness, madness, schizophrenia - Vindictive, critical, complicated - Disobedient.
I would like to share with you the following.
Standing, sitting or lying down, breathe in the name MITZRAEL by inhaling through the nose, and hold your breath a few seconds. Then, exhale slowly and progressively through the nose. Repeat the exercise as long as needed to create a state of calm. Then you can continue by breathing freely while continuing to invoke MITZRAEL keeping the eyes closed.
By invoking or repeating the Sacred Formula represented by the Angel's name, we create a passage between the conscious, the subconscious and the different layers of the unconscious, thus reprogramming the different Angelic states of consciousness within, and allowing ourselves to reconnect with our celestial origin. The objective of this work is to purify our soul and become totally conscious in order to rediscover the Knowledge that lies within.
MITZRAEL is your Angel number 1 (Physical) if your Birthday is Jan 16th to 20th
MITZRAEL is your Angel number 2 (Emotional) if your Birthday is: May 20th in the afteroon and May 21st , Aug 4th, Oct 17th, Dec 27th (with Angel Harahel duriing the day), March 8th.
MITZRAEL is your Angel number 3 (Intellectual) if you are born: 19h40 to 19h59 p.m.
In the picture of the Tree of Life, this Angel resides: HOD/ Specificity GUEBOURAH
This information is taken from The Book of Angels, and Les Ailes de la Vie (Wings of Life, 2nd Edition)and Traditional Angelology and Angelica Yoga written by Kaya and Christiane Muller, Univers/Cité Mikaël. www.72angels.ca
Pema Norpal
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For a complete list of Raffle Winners winners [click here]
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are accurate; however, no valid claim may be based on information contained herein.
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official winning numbers, the official winning numbers as certified by the Multi-State
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Get a free comparative market analysis of your home's value sent to you with no obligations.
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ORIGINS Automagically eye lining pencil
- £15.00
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Nothing could be finer than an automatic eye liner. Now lining and defining is Automagically easy to do with this eye lining pencil by Origins. The uniquely designed precise pencil point package gives super smooth zoom-along lids accuracy. The most up-to-the-minute soft, creamy formula delivers hours of lasting wear. And this new, user-friendly package conveniently allows you to see how much product is left, taking the guesswork out of eye lining.
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The demand for new and innovating low vision products like electronic magnifier continues to grow because the number of people with vision loss is increasing quickly. This is mainly due to the fact that the senior population is growing. Many forms of low vision are age related such as age-related macular degeneration (AMD), cataracts, glaucoma, diabetic retinopathy, or optic nerve disease. These optical related diseases are common among senior citizens. Age related macular degeneration accounts for almost 45 percent of all cases of low vision in the US.
A video magnifier is a low vision aid and is one of the most popular and effective devices for making things easier to see. This electronic magnification device is used for reading tiny font as found on prescription labels, restaurant menus and store receipts. A video magnifier is enlarges images of text and objects on a monitor or screen. An image of the material to be magnified is captured by a digital video camera, sometimes called a CCD (charge-coupled device) camera. The digital video camera is connected to a monitor or screen on which magnified images are displayed. These video magnifiers come in two varieties on is handheld and portable. The other type of magnifier is a "table" like device and items are placed under the camera and viewed on a screen.
Best Selling Video Magnifiers on Activeforever.com
inSite Portable Video Magnifier is a convenient and portable digital magnification tool to help those with low vision read small text, maps, medication labels, and more. Designed to help people who suffer from macular degeneration or other vision an extremely lightweight digital magnifier (4.5oz), the inSite boasts a top of the line super bright 3.5" TFT LCD screen. The inSite also incorporates a unique freeze-frame feature that allows the user to temporarily save the image on the screen for easier viewing. A truly innovative and affordable device, buy your inSite Portable Video Magnifier from ActiveForever.com today!
The Enhanced Vision Pebble Portable Video Magnifier is a lightweight, affordable video magnifier that is an ideal magnification tool for those that may be suffering from poor vision, macular degeneration, glaucoma and other visual impairments. The high resolution LCD display with adjustable brightness is perfect for home or travel use and its compact size can fit in your purse or pocket. Buy your Enhanced Vision Pebble Portable Video Magnifier from ActiveForever.com!
Lightweight and designed for travel, the Traveller+ Portable Flat Screen Video Magnifier helps those with macular degeneration and impaired vision by magnifying images up to 16 times on its high quality video screen. Whether you are reading magazines, writing checks, taking notes, or reading maps, this compact low vision device will suit your individual vision needs at home or on the go. An automatic shut-off feature helps conserve battery power, and the integrated rechargeable battery offers up to 2 hours of continuous, crystal clear viewing. For extra magnification, the Traveller+ Portable Flat Screen Video Magnifier can be plugged into the video input of any standard television using the provided cable.
The Bierley MPD-12-Mono Desktop Video Magnifier is an innovative low vision magnification device designed to provide a compact and convenient multi-use magnifier, photo display and digital clock, all in one unit. The integrated 12" digital LCD screen can be set to continually display a large-print digital clock, or change modes and the MPD-12 crisply and clearly displays anything you point the unique handheld camera system. Change modes again, and with the included 1GB Bierley USB flash drive, you can display up to 1000 of your favorite and most treasured images all on a continuous loop.
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Phase II Trial of Intermediate-Dose Cytarabine to Modulate EWS/FLI for Children and Young Adults With Recurrent or Refractory Ewing Sarcoma
Drugs used in chemotherapy, such as cytarabine, work in different ways to stop
the growth of tumor cells, either by killing the cells or by stopping them from dividing.
This phase II trial is studying how well cytarabine works in treating young
patients with recurrent or refractory Ewing`s sarcoma.
Study Status: Completed
Verified by
Children`s Oncology Group
August, 2013
Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Cleveland Clinic Taussig Cancer CenterCleveland, Ohio 44195United States
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Cheap ski holidays in hundreds of ski resorts worldwide.
Everybody likes a bargain, ourselves included! That's why we offer ski deals to over 100 ski resorts in 20 countries, exclusive offers and great savings to chalets, hotels and apartments, providing you with a constant stream of great offers, including ski chalet deals. As we update our cheap ski holidays on a daily basis you can be sure that the prices you are looking at are the very latest available. There are also some great group deals that can often be combined with the deals below.
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Starbucks is doing it again! Take advantage of a buy one, get one FREE holiday beverage at Starbucks now through December 16th from 2-5pm. You have a choice of a Peppermint Mocha, Caramel Brulée Latte or Gingerbread Latte. Grab a friend and enjoy a chat over a latte!
Please check if your local Starbucks is participating in this offer.
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Comprehensive immigration reform, a policy concept that first gained currency in 2001 in the U.S. political world, would marry increased border enforcement with legalization for unauthorized immigrants and the ability to bring in future workers needed by the U.S. labor market. Debated in the U.S. Senate in 2006, 2007, and 2013, comprehensive immigration reform (CIR) would touch virtually every facet of the U.S. immigration system. The policies and many effects that would flow from CIR legislation are analyzed here.
Slightly more than 2.1 million unauthorized immigrant youth and young adults could be eligible to apply for legal status under the 2010 DREAM Act, though historical trends indicate that perhaps fewer than 40 percent would obtain legal status because of a variety of limitations. This policy brief offers detailed estimates of potential DREAM Act beneficiaries.
The conference, co-sponsored by Georgetown Law, Catholic Legal Immigration Network, Inc., and the Migration Policy Institute, focused immigration and refugee law and policy.
A discussion on possible reforms to the immigration adjudication system and the recent report on the topic by the American Bar Association's Commission on Immigration.
For MPI's Leadership Visions Speakers Series, John Morton, DHS Assistant Secretary, candidly spoke about his pespective on ICE, its mission, and its future.
Voters' brains connect words, phrases, images, values, and emotions, and these connections — known as networks of association — influence their receptiveness to political messages, often far more strongly than facts and rational arguments. This report shows that to reach those who have not yet made up their mind on a particular issue, advocates and leaders need to understand the associations a term such as "immigrant" spark in the mind of the electorate and strengthen positive associations while weakening negative ones.
Recent developments in the United States (including the 2008 elections and shifts in organized labor's stance on immigration) have created new openings for comprehensive immigration reform, possibly including a path to legal residence and citizenship for illegal immigrants. But the author argues that the extent of this opening may be overstated by some advocates.
In this memo, a veteran immigrant-rights strategist, Frank Sharry, offers his views on the politics and policy of achieving immigration reform.
This conference offers law and policy analysis and discussion on cutting-edge immigration issues.


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AW Janeen! I love that he keeps a journal of all the cool stuff! He's so sweet.
AW Janeen! I love that he keeps a journal of all the cool stuff! He's so sweet.
Ashley - 25, Chris - 27, Elizabeth - 9-22-04, Alexis - 12-19-08
Just the fact that he did it is what blows my mind. I mean the majority of stuff in there isn't mushy or whatever but the fact that he kept up on it all and typed it so he could remember it is to me. I asked him today "Where did you come from? Most guys just don't do this kind of stuff!"
Naw, most of what he wrote wasn't mushy, but it's the thought that is mushy. If that makes sense. lol
Ashley - 25, Chris - 27, Elizabeth - 9-22-04, Alexis - 12-19-08
Awesome diary. Thanks for sharing.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
I confess that I feel like an unsympathetic shlup. Dbf came home, again, yesterday around 5:30 with a good buzz on and continued to drink throught the evening. As the night went on he was wallowing deeper and deeper in self pity. Oh, and course most of his problems are my fault because I don't have sex with him enough, and I'm not "helping" him with what he's going through. Well #1 is that I don't know what he's going through because he's been telling me all the counseling is for his short term memory function. #2 is that I don't have time to take care of him. I have 2 children and a full time business and I am 100% responsible for all of it. #3 is quite simply that his attitude and lack of helping me out is a total and complete turn off for me.
I just really believe that self improvement has to come from within. No one can help you with that. I muddle through things on my own all of the time.
This post probably barely makes sense and it's because last night didn't make much sense to me either. The only time he opens up to me is when he's drunk and then he just spews bitterness and blame. I can't bring myself to feel sorry for him. I just can't.
I confess I now know someone with confirmed H1N1. Flutterbudget's son Luke was diagnosed earlier this week. And both she and her DH are sick with the exact same symptoms as Luke, so I'm sure they all have it.
I confess I can't imagine me, DH, and Liam all having a flu together. How miserable would that be?
He's telling me today that he didn't mean any of the crap he said last night. So goes my life. Forever wondering if the things coming out of his mouth are genuine or BS.
Bridget, am I understanding correctly that your dbf got drunk and unhappy about you not meeting all of his needs, in the bedroom and out of it? I don't even know what to say about that, except he seems to live in his own world, without a lot of self-awareness or reflection, and only occasionally has a shining moment of generosity to make all the bad times seem a little less miserable. I am glad he's going to a counselor (and I really doubt he's sleeping with her, since they are in a professional relationship with overt ethical guidelines) and I would try to ask him more about what his issues are. Probably not in the same way I said it, though. Maybe you could go together sometime? If he's having difficulties, it wouldn't hurt to insert yourself in a session and provide some input and give some context to his situation, and hopefully learn a little bit more in the process.
My mom has stayed with my dad for more than 20 years after his affairs, long-term mistresses (sometimes people call him "the man with two wives"), and his disregard, avoidance, and disrespect. She's living out here near me, now, but she doesn't think it's permanent and she still goes home 4-6 times a year. She ends up cleaning the house while he goes somewhere else for the weekend so he doesn't have to talk to her.
I have asked her why she has stayed with him for so long when he's not very nice to her, and she tells me that when he IS nice, he's so wonderful, and she hopes to be able to see that again. In the meantime, she can see him being charming around his friends, if she's in the vicinity.
I will support my mom no matter what she decides to do. I have no business telling her what to do with her relationship. It makes me a little sad, sometimes, thinking that if she'd left him 20-30 years ago, when he first started having significant affairs (and yes, I was aware of it even at the age of 7), she might have found a nice man and been happier this whole time. Or she might have been lonely and unfulfilled, too, but she is anyway.
I just want you to be treated with courtesy and respect. That doesn't seem like too much to ask, but it can be so hard to achieve.
I'm sorry if this seemed preachy. It really wasn't meant to be, and I have no more business giving you relationship advice than I have giving my mom advice.
That's really sweet.
I feel so wanted at work. I'm currently doing a maternity cover which is up soon, so I went for an interview outside my department. I've progressed to the second stage of interviews. And now, my current boss says she wants me to stay when the girl I'm doing maternity cover comes back! So, choices choices. I'm pretty sure I'll stay where I am.
Ashley - 25, Chris - 27, Elizabeth - 9-22-04, Alexis - 12-19-08


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I have to be honest, I gave this movie an advantage by accident. See, I showed up for it a half hour early because I had the wrong start time. I hate waiting so I walked over to Applebee's, sat at the bar and had a drink. Well, that turned into three or four drinks and before I knew it, I was drunk. I staggered over to the theater, bought a popcorn that was too big for me and plopped down for the movie. When you think about it though, that's a perfect metaphor for The Expendables franchise; you know it's not good for you but you just can't stop yourself from enjoying it. Sure, you may not feel too well when it's all done but you'll have a pretty good time while you're in it.
This film series that prides itself on being nothing but mindless shoot-em-ups is now in its third installment and it's more of the same. The only difference is that along with the returning cast members of Sylvester Stallone, Arnold Swarzenegger, Jason Statham (Transporter, Snatch), and Dolph Lundgren (Rocky IV, Masters of the Universe) are joined by a lot of new faces. The old timers that were added are inspired and brilliant; we have Wesley Snipes (the Blade trilogy, To Wong Foo), Kelsey Grammar (X-Men 2, Fraiser), Antonio Banderas (Desperado, the Shrek films), Harrison Ford and Mel Gibson.
All these A-listers showing up in the series for the first time is excellent and elevates the film to a new level. Banderas especially is hilarious as an out-of-work mercenary who is thrilled that he's just part of a team again. His character is stupid and silly but Banderas' commitment to it is pretty awesome. I also love seeing Gibson in a film again. I know he's an a-hole in real life but the man is a talented actor and even more talented director; I hate that Hollywood has turned its back on him. He's the villain in The Expendables 3 and he seems like he hasn't missed a beat during his hiatis. Like all the characters in this series, it's cliche and paper-thin but Gibson plays it perfectly.
Where the movie is pretty off-putting is the painfully obvious addition of new, younger characters. I don't mind it when a film franchise is reset with new characters. If you're a huge fan of the series it's exciting to know that a new team will carry the torch onward. The first problem with these new characters is that they're played by Kellan Lutz (the Twilight series), Glen Powell (The Dark Knight Rises), professional boxer Victor Ortiz and super sexy MMA fighter Ronda Rousey. You might be thinking to yourself, "WTF?" Yeah, that's exactly right. If these are the people that Stallone has invested his retirement fund in, he's in trouble. The other problem with it is that, even if they were good actors, which they're not, that's not what makes The Expendables fun. You watch these movies to see an all-star cast of ghosts of action film past dust off their fists, do some deep stretches and get back out there doing things you thought you'd never see them do again. Without that, it's just another sh**ty action movie.
It's common that people get disgusted by a franchise that feels like it's squeezing blood from a Stallone...I mean stone. This film doesn't feel like it yet. In fact, I think it's the best in the series but that's like being the skinniest kid at Fat Camp. They're bad films that are fun to watch. Again, that's why it's appropriate that I watched this with a brain falsely wired on alcohol, salt, sugar and fat. When I sobered up halfway through, I did feel a little gross enjoying the film as much as I did. But if you're considering going to see The Expendables 3, you know exactly what you're getting into and you know whether or not you want to see way before you read this sentence.
Screenwriting 101 teaches that films are divided up into three acts; there's the set-up, the conflict and the resolution. The most common problem that comedies have is that the first act is killer and then it gets progressively less funny as the film goes on. In my opinion, The Hangover was the best example of this. The ending of that movie has me barely smiling, let alone not laughing. Sex Tape is interesting because it's almost the exact opposite. It's a comedy that starts off horrendously unfunny, has a spectacular middle and a final act that certainly doesn't finish strong but it is way better than how it starts.
Jason Segel will always hold a special place in my heart for being someone who fought hard to bring The Muppets back into the spotlight. I want to give him a pass for every bad performance he has and this is no exception. Segel is paired up with Cameron Diaz again (the last time was in Bad Teacher) as a couple who has fallen into the quagmire of marriage that centers around routine, low energy, children's needs and, of course, no sex. The fact that Diaz shares almost every frame with Segel highlights the fact that these are two actors that aren't really that great. They are very apt and have made a fortune at playing themselves in movies and that's all we can expect from them.
The premise of the movie is funny and somewhat relatable for anyone in a similar situation. The couple decides to make a sex tape (it's not just a clever title) in an effort to spice up their love life. Predictably, Segel forgets to delete it and it's sent out to everyone in a very effective advertisment for how great Apple is at backing up files. It's a one-joke movie that never really goes anywhere beyond exactly where you think it will. There are no twists. There are no turns. If you have even half of a brain you can see every joke and situations happening before they happen.
The best moment in Sex Tape and perhaps one of the funniest sequences in any comedy this summer is a 15-minute-long scene that takes place at Diaz's perspective boss' house, who's played wonderfully by Rob Lowe. Jake Kasdan is Sex Tape's director. Despite the fact that he directed the dud Bad Teacher, he's also responsible for Walk Hard and Orange County, two HIGHLY underrated comedies of the last 15 years. That scene at Lowe's house is as funny as anything in those films. It's almost worth the cost of admission alone...almost. The problem is that it's a totally different tone than the rest of it. It's frustrating because it's so bizarre, crazy and well done that you wonder why Kasdan didn't execute the rest of the film in the same way.
Sex Tape is being billed as the ultimate date movie. I don't know if that's necessarily true but it does do a good job of not leaning too girlie or too much for bros. Sure, Diaz gets naked and she's still smoking hot but Segel lost a lot of weight to make him somewhat better looking for the women in the audience too. Both sexes have their perspective and emotions expressed in equal amounts of time too. The balance they strive for is impressive but it's not enough. Not sure if any of you have ever made a sex tape but the movie is a lot like them; seemed like a great idea but once you're in it and forced to watch it, you're filled with regret because it's awkward and makes you wish you never did it in the first place.


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Melissa's Q & A
Who's your favorite sports team, and why?
The San Francisco Giants are my favorite sports team! They're from one of my all-time favorite cities. I make sure to go to several of their games every season. Go Giants!
What's your favorite movie quote?
"I always tell the truth, even when I lie." -Scarface. That movie is sick.
What's your favorite video game, and could you kick our butts at it?
My favorite video game is Aladdin from Super Nintendo. lol. that's probably the last game i played.
Piercings/Tattoos (How many? Where?)
Belly button piercing. Tattoo on my right wrist, Tatt on my right buttcheek, and a tattoo on my upper inner arm
What's the most embarrassing song on your iPod?
Selena Gomez's "Love you like a love song" I have to be in the mood to play it though ;)
What's your best party trick?
Showing off my double jointed thumbs
What's the most memorable pick-up line you've ever heard?
That im their "future ex-girlfriend" it made me laugh
What's the worst job you've ever had?
A hostess at an upscale restaurant. My boss was an arrogant jerk!
What's the most dangerous thing you've ever done?
Climbing up a 12 story building that was built in the 1930s and im pretty sure that ladder was that old because some spots were unbolted and i didnt know it until i climbed up it.
It's 4AM after a crazy night out – what are we eating?
Breakfast fooooood!
What's the strangest thing in your fridge right now?
my NuvaRing hah
What's the naughtiest thing you've ever done in public?
Got frisky and went all the way
What do you feel sexiest wearing?
Lingerie and stilettos
Tell us a joke.
God, im soo bad at jokes.Okay, A woman gets on a bus with her baby. The bus driver says: "that's the ugliest baby i've ever seen! ugh!" The woman goes to the rear of the bus and sits down, fuming. She says to a man next to her: "The driver just insulted me!" The man says: "You go right up there and tell him off-go ahead, ill hold your monkey for you."


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A febrile seizure is a convulsion (shaking, twitching, muscle tightness) or fainting associated with a fever. It occurs in infants or small children. This seizure is not associated with any other illness or medical condition except the fever.
There are two types of febrile seizures called simple and complex. They are determined by the length of seizure, how often they recur and recovery characteristics:
Simple febrile seizures:
- Convulsions last between a few seconds to 15 minutes
- Seizures are followed by a period of confusion and sleepiness which slowly goes away
Complex febrile seizures:
- Last longer than 15 minutes
- Occur more than once within 24 hours
- Convulsions which affect only part the body
High body temperature due to a fever is believed to trigger the seizure. The fever is most often caused by common viral infections. Some febrile seizures may be caused by fever after routine immunizations .
Risk Factors
Age is the greatest risk factor. Febrile seizures occur between the ages of three months to five years. Most febrile seizures occur in children between 6 months to 3 years of age. In general, the younger the age that the first febrile seizure occurs, the more likely it is that a child will have another seizure.
There is some evidence that a tendency for febrile seizures may run in families.
Signs of a febrile seizure include:
- A fever, usually above 102°F (38.9ºC)
- Convulsion (jerking or stiffening muscles)
- Abnormal eye movements
- Coarse breathing sounds during the convulsion
- Loss of consciousness
- Loss of bladder or bowel control
- Vomiting
- Brief period of drowsiness or confusion following a seizure
If you suspect your child is having a febrile seizure, stay calm and follow these steps:
- Unless the doctor has told you otherwise, call 911.
- Protect from physical injury. Place your child on the floor or bed away from any hard or sharp objects.
- Protect the airway. Do not place anything in the mouth during the convulsion. Turn the child's head or body to the side. This will allow saliva or vomit to drain from the mouth.
- Watch the time. The length of the convulsions should be less than five minutes.
Your doctor will diagnose febrile seizure based on information of the seizure and your child's health. The doctor will also look for other medical conditions that can cause a seizure and fever. They include meningitis , encephalitis , or any other intracranial disease. Your doctor will rule these out before diagnosing a febrile seizure.
To determine the source of the fever or rule out other conditions your doctor may order:
- Blood tests
- Urine tests
- Lumbar puncture —procedure to remove a sample of spinal fluid to look for meningitis or encephalitis
Additional evaluations of the brain may be needed after complex febrile seizures. This is done to look for any injuries due to prolonged or severe seizures. Tests may include:
- CT scan —a type of x-ray that uses a computer to make pictures of structures inside the head
- MRI scan —a test that uses magnetic waves to make pictures of structures inside the head
- Electroencephalogram (EEG)—a test used to evaluate brain function or disorders
Children will eventually outgrow febrile seizures. The treatment goal is to manage fevers that may cause seizures. This may be done by addressing the underlying infection. The treatments may include medication.
To address the underlying cause of fever your doctor may recommend:
- Antibiotics or antiviral medications
- Acetaminophen or ibuprofen to fight the fever
Your doctor may recommend a rectal valium gel. This gel can interrupt seizures. It may be recommended if your child has frequent seizures and the seizure lasts more than 4-5 minutes.
About 30% of children will suffer another febrile seizure when they have a fever. Unfortunately, a fever can happen suddenly. The seizure can be the first sign. Simple febrile seizures can be scary but do not harm the brain. As a result preventative treatment is often not recommended.
Daily antiseizure medicine may prevent seizures in children with prolonged or frequent seizures. Examples of these medicines are phenobarbital and valproic acid . These medicines do have significant side effects. Talk to your doctor about preventative medication.
Follow up with your doctor as recommended. Very few will develop long term problems like adult- epilepsy . There is less than 1% risk for of developing adult epilepsy in a child with a simple febrile seizure. This risk is higher for children with:
- A complex febrile seizure
- Problems in development before the febrile seizure
- A family history of a seizure disorder
Revision Information
- Reviewer: Kari Kassir, MD
- Review Date: 09/2013 -
- Update Date: 09/30/2013 -


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Time is money, the old adage goes, but so is a well-winterized house. Stopping air leakages can take as much as 30 percent off your heating bill, according to the U.S. Department of Energy.
Check out these three tips for closing up air leaks around your home:
- First, do an energy audit of your house, keeping an eye out for the trouble spots. Windows and doors are obvious places to check, but also look at things like wall outlets and switches, plumbing vents and the attic hatch for leakage. Swaying curtains and light under your doors are sure signs, but you can find less obvious air leaks by using an infrared thermometer to check for temperature variations. Or use a lighted candle (carefully). If the flame moves, air is coming in.
- Seal the outside of windows with a good quality silicone caulk; use rope caulk on the inside (it can be removed in the spring). Or cover windows with a transparent film, using a hair dryer for adhesion. Other air leaks can be sealed with caulk or self-adhesive weather stripping.
- Installing insulation yourself is not easy, but if you have an older home, chances are you need to add more. If the insulation is level with or below the floor joists, you should add more, according to Energy Star, a joint program of the Environmental Protection Agency and the Department of Energy.
How do you save energy around the house? Share your tips in the comments section below.


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Paul Stanley Blames 'East Coast Mafia' For Kiss Rock Hall Snub
Thursday, October 11, 2012
Kiss is back with it's 20th album, Monster, which was co-produced by Paul Stanley. Stanley spoke to Rolling Stone about the new set and also touched upon the fact that Kiss has once again failed to make the shortlist for the Rock and Roll Hall of Fame. When asked if it bothered him, Stanley said, "No, because I think it's so transparent. You have the East Coast music Mafia -- they are clearly more motivated by each other than reality. Filling their criteria is leaving them at this point some pretty slim pickings. Would we accept? Of course, because it matters to our fans. So, I would be gracious. But honestly, it means nothing to me. My life is far beyond anything I could have anticipated and will continue to be so without a new doorstop."
The latest lineup of Kiss features drummer Eric Singer and lead guitarist Tommy Thayer dressed as original members Peter Criss and Ace Frehley, respectively. Stanley was asked if he has any contact with the Kiss co-founders: "No. It's not out of animosity. It just has no point in my life today. Safe to say, the band wouldn't be here without those guys having been in it. The band also wouldn't be here today if those guys were still in it. I respect and love what we created together, but that was a long time ago."
Stanley spoke about how his early influences helped inform the sound of Monster: "I wanted to make an album that really hearkened back to why I got into this in the first place. I was lucky enough as a kid to spend most of my weekends at the Fillmore East. On a great night, that was like a Holy Roller evangelical church. When rock n' roll is done with that fervor, it's close to gospel. That's what I wanted to go for with this album -- passion as opposed to perfection. James Brown wasn't perfect. Motown, the Beatles, the (Rolling) Stones, (Led) Zeppelin, early Elvis (Presley) -- I wanted to maintain the essence of it, getting a first, second or, if you really had to push it, a third take and record on analog tape and capture the intensity of what you're doing, and not compromise it."
Paul Stanley told us that he wanted Monster to contain everything that he loved and admired about his favorite records growing up: "I'd like to think that the bands that you are influenced and inspired by doesn't necessarily mean that you mimic them. It means that their passion, or their approach is inspirational. So, whether its gospel, or Motown -- it all is music of passion. And that's what I think we wanted to and I wanted to see us channel was the passion and the fervor that all the music I loved had. Y'know, its not about perfection -- it's about passion."
On October 31st, Kiss kicks off its "Kiss Kruise" in Miami aboard the Norwegian Cruise Line, Norwegian Pearl.
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New Studies May Aid Movement Toward Targeted
Cancer Treatment
Three new studies highlight advancements being made toward individualized molecular classification of specific cancers and the potential for more targeted therapy. Two studies released in advance online publications of Science and the New England Journal of Medicine (NEJM) identified mutations of the epidermal growth factor receptor (EGFR) gene in certain non-small-cell lung cancer (NSCLC) patients that render their tumors sensitive to the drug gefitinib (Iressa). In the third study, published in the April 29 NEJM, investigators reported that they had identified a six-gene "signature" using microarray analysis that can be used to predict the response of diffuse large-B-cell lymphoma patients to standard chemotherapy.
Gefitinib was approved by the U.S. Food and Drug Administration last May as a third-line therapy for NSCLC, which accounts for 85 percent of lung cancer cases. However, previous clinical trials testing gefitinib have shown significant variability in response rates. For example, 10 percent of patients responded to gefitinib in a clinical trial with mostly patients of European ancestry, whereas a 27.5 percent response rate was demonstrated in a clinical trial with solely Japanese patients. Read more
Conference Affirms Priorities, Strategies for 2015
"An investment in knowledge," said Benjamin Franklin, "always pays the best interest." Perhaps without officially proclaiming it, this has been the cancer community's mantra. We have made a tremendous investment in learning as much as we can about cancer and it has paid untold returns. We have amassed enough knowledge that I believe we now have the edge on this disease: We have a distinct understanding of the process by which it develops and becomes lethal and, more importantly, we have learned its vulnerabilities. And every day that store of knowledge grows, amassing more power.
This was part of the message I delivered during an intriguing and exciting meeting last week, the Milken Institute Global Conference. Nearly 2,000 leaders from the worlds of business, public and foreign policy, academia, and other arenas participated. Along with some of America's most brilliant medical minds, including Nobel Laureates Drs. David Baltimore and Lee Hartwell, I had the honor of participating in five panels that all shared a common theme: identifying the steps that must be taken to make important, needed advances in medical care. Cancer was the focus of several of these sessions. Read more
New Studies May Aid Movement Toward Targeted
Cancer Treatment
Three new studies highlight advancements being made toward individualized molecular classification of specific cancers and the potential for more targeted therapy. Two studies released in advance online publications of Science and the New England Journal of Medicine (NEJM) identified mutations of the epidermal growth factor receptor (EGFR) gene in certain non-small-cell lung cancer (NSCLC) patients that render their tumors sensitive to the drug gefitinib (Iressa). In the third study, published in the April 29 NEJM, investigators reported that they had identified a six-gene "signature" using microarray analysis that can be used to predict the response of diffuse large-B-cell lymphoma patients to standard chemotherapy.
Gefitinib was approved by the U.S. Food and Drug Administration last May as a third-line therapy for NSCLC, which accounts for 85 percent of lung cancer cases. However, previous clinical trials testing gefitinib have shown significant variability in response rates. For example, 10 percent of patients responded to gefitinib in a clinical trial with mostly patients of European ancestry, whereas a 27.5 percent response rate was demonstrated in a clinical trial with solely Japanese patients.
Though a minority of patients responds to treatment with gefitinib, confirmed Dr. Frederic J. Kaye of the NCI Clinical Genetics Branch, a coauthor of the Science report, these new findings will allow physicians to identify the subset of patients who are most likely to benefit from the drug.
The EGFR protein, the cellular target of gefitinib, is a member of the tyrosine kinase family of proteins - a class of enzymes involved in cellular signaling that is commonly mutated in a number of different cancers. These mutations are believed to disrupt EGFR's ability to regulate itself, thus triggering its signaling pathway to induce uncontrolled cell growth. However, these mutations also render "the mutant EGFR proteins much more sensitive to gefitinib," added Dr. Kaye.
In both the Science and NEJM studies, the presence of EGFR mutations correlated with clinical response to gefitinib. The mutations were more prevalent in Japanese patients than in Caucasian patients. Tumors from 25 new Caucasian patients were also examined: 14 that responded to gefitinib and 11 whose cancer progressed during treatment. Thirteen of the 14 tumors from responders were found to have EGFR mutations, whereas no EGFR mutations were detected in the 11 tumors from patients that progressed.
These findings should improve the outcome for many patients with NSCLC and may lead to the development of other molecularly targeted drugs to treat patients with other cancers that have known EGFR mutations, such as glioblastoma. "This data powerfully validates and reenergizes the approach of targeted therapy and should impact the design of future clinical trials," said Dr. Kaye.
In the NEJM study on diffuse large-B-cell lymphoma, instead of identifying genetic mutations that predict treatment response, researchers were able to identify six genes that, when present in patients, predicted their response to standard chemotherapy.
The goal of the study, explained authors Dr. Izidore S. Lossos and colleagues from Stanford University, the University of Miami, and Applied Biosystems, was to validate previous findings that identified genes and gene signatures for predicting treatment response and to formulate these into "a model that was technically simple and applicable for routine clinical use." Their model uses the molecular characteristics of lymphoma to divide patients into three pools of risk that reflect overall patient survival and can help determine the most appropriate treatment for individual patients.
"Lossos and coworkers have passed a milestone in the development of clinical diagnostic tests for cancer," wrote Dr. Sridhar Ramaswamy in an NEJM editorial. Their findings translate diagnostics, he continued, "from unbiased, genome scale surveys of gene expression in human tumors to the creation and initial validation of a novel diagnostic tool that should fit easily into clinical practice and might refine the currently available measures used for risk stratification."
Conference Affirms Priorities, Strategies for 2015
"An investment in knowledge," said Benjamin Franklin, "always pays the best interest." Perhaps without officially proclaiming it, this has been the cancer community's mantra. We have made a tremendous investment in learning as much as we can about cancer and it has paid untold returns. We have amassed enough knowledge that I believe we now have the edge on this disease: We have a distinct understanding of the process by which it develops and becomes lethal and, more importantly, we have learned its vulnerabilities. And every day that store of knowledge grows, amassing more power.
This was part of the message I delivered during an intriguing and exciting meeting last week, the Milken Institute Global Conference. Nearly 2,000 leaders from the worlds of business, public and foreign policy, academia, and other arenas participated. Along with some of America's most brilliant medical minds, including Nobel Laureates Drs. David Baltimore and Lee Hartwell, I had the honor of participating in five panels that all shared a common theme: identifying the steps that must be taken to make important, needed advances in medical care. Cancer was the focus of several of these sessions.
It was immensely encouraging to witness the participants' almost uniformly positive feelings about our ability to defeat cancer. Beyond that, however, was the agreement about the roles technology and communication must play in this process. At NCI, we have embraced these same conclusions and have launched initiatives to make them a reality.
Take the cancer Biomedical Informatics Grid, or caBIG. With this initiative, we are using technology to connect all cancer researchers and provide unprecedented access to data and tools that will improve research efficiency. Then there is the National Advanced Technologies Initiative for Cancer, with which we are creating a coordinated national infrastructure to improve the availability of and access to key technologies. We also have made important investments in fields such as nanotechnology and proteomics, and are driving advances in areas like imaging.
On several occasions, panel members bemoaned the expense and time now required to bring a new drug to market: approximately $800 million and more than 15 years. Greg Simon, president of the Center for Accelerating Medical Solutions, put it bluntly when he called the latter figure an "awful number." I agree. And I believe that technological advances can and will dramatically shorten this time.
But technology is only part of the solution. Again and again, conference participants talked about the necessity of collaboration and communication - not just between one or two segments of the medical establishment, but among all those with a stake in preventing illnesses from taking more lives. That means researchers, clinicians, advocacy groups, patients, technology companies, pharmaceutical companies, regulators, and others.
Again, NCI is leading the way. Through our partnership with the U.S. Food and Drug Administration, for example, we are developing processes to ensure that clinical trials are more efficient and effective, and that positive results are more quickly translated into new diagnostic or treatment options for patients. With caBIG, we are creating an entirely new portal to connect researchers, clinicians, advocates, patients, and others.
Overall, I returned to NCI late last week with a strong affirmation that we are indeed on the right track - on the path to 2015. And if the conference participants' attitude is any indication, I think we can count on a lot of help.
Dr. Andrew C. von Eschenbach
The Health Care Provider's Role in Helping Smokers Quit
Tobacco use is the leading preventable cause of death in the United States. Cigarette smoking is responsible for the vast majority of lung cancer deaths, and it is a major contributor to deaths from coronary artery disease, chronic obstructive pulmonary disease, and stroke. In 2004, approximately 160,440 people will die from lung cancer - the leading cause of cancer mortality. Cigarette smoking also causes cancers of the larynx, mouth, esophagus, pharynx, and bladder. In addition, it plays a role in cancers of the pancreas, kidney, and cervix. Seventy percent of smokers say they would like to quit, but the interaction of nicotine addiction and behavioral and social factors makes quitting very difficult.
The good news is that current evidence serves to remind us that health care providers can play a key role in helping smokers quit. As reported in the April 21 Journal of the National Cancer Institute, Katz et al. found that providers who used a brief intervention to help their patients quit smoking significantly increased abstinence rates six months later, especially among heavy smokers. The authors noted that for the 70 percent of American smokers who visit their physicians at least once a year, exposure to an intervention could lead to smoking cessation for approximately 2 million patients annually.
The study highlights both the effectiveness of interventions and barriers to implementing behavioral risk- reduction strategies in health care settings. It was based on the 1996 Agency for Healthcare Research and Quality (AHRQ) Smoking Cessation Clinical Practice Guideline, which has since been updated and expanded in the 2000 U.S. Public Health Service publication, Treating Tobacco Use and Dependence (http://www.surgeongeneral.gov/tobacco/
National data suggest that many smokers are not advised to stop smoking or offered assistance with smoking cessation during a given visit with a health care provider. Providers are encouraged to review and use Treating Tobacco Use and Dependence. It contains evidence-based information about effective behavioral counseling, first-line pharmacologic therapies (bupropion SR, nicotine gum, patches, inhalers, and nasal sprays) and second-line pharmacologic therapies (clonidine and nortriptyline). It also recommends a simple five-step approach to cessation counseling: ASK about smoking; ADVISE smokers to quit; ASSESS willingness to quit; ASSIST the patient in trying to quit; and ARRANGE follow-up. This approach can save lives. And it is important to note that an intervention need not be delivered by a physician to be effective. Katz et al. utilized intake staff: nurse practitioners and physician's assistants.
In this week's guest commentary, Dr. Carolyn Clancy, director of AHRQ, offers insights on the clinical practice guidelines and the importance of provider-patient interaction in achieving smoking cessation success. One of NCI's many collaborations with AHRQ was the partnership effort on the National Blueprint for Disseminating and Implementing Evidence-Based Clinical and Community Strategies to Promote Tobacco Use Cessation (http://www.ctcinfo.org/upload/blueprint_adult.pdf). NCI continues to work with AHRQ, NIH colleagues, and many other partners to ensure that providers have the resources they need to learn about and implement effective cessation strategies in clinical settings.
NCI has long supported tobacco use and treatment research. Studies range from transdisciplinary approaches to understanding the complex interactive determinants of tobacco use initiation, maintenance, and cessation to the development of more effective behavioral and pharmacologic approaches to tobacco use cessation. NCI's clinical trials include several smoking cessation trials (http://clinicaltrials.gov/ct/search?term=smoking+cessation) to which we encourage health care providers to refer patients. Through state-of-the-art research efforts, the opportunity exists to improve health directly while identifying clinical applications, successful interventions, and knowledge that can be used in health care settings around the world.
NCI offers several options for smokers who are trying to quit. The information and professional assistance available at http://www.smokefree.gov helps support smokers as they become - and remain - nonsmokers. The site provides immediate assistance in the form of an online step-by-step cessation guide; access to local and state telephone quitlines; NCI's personalized telephone-based service (1-877-44U-QUIT) and instant messaging; and targeted publications, which may be downloaded, printed, or ordered. In addition, providers will find a section with evidence-based resources they can use to help patients quit.
Clearly, NCI cannot achieve its goal to eliminate suffering and death due to cancer without dramatically reducing and treating tobacco use and tobacco-related cancers. Health care providers must be full and active partners in these efforts to take the steps necessary to reduce tobacco use in the United States.
House Hearings Focus on NIH Appropriations
The House Appropriations Subcommittee on Labor, Health and Human Services, Education and Related Agencies held hearings relating to the NIH on April 21 and 22. The first day focused on NIH scientific research, and the second day highlighted NIH management. The principal witness for both hearings was NIH Director Dr. Elias Zerhouni.
In his opening testimony, Dr. Zerhouni spoke about the public health challenges facing the nation in the 21st century, which will drive NIH research priorities. He discussed the NIH roadmap initiatives and his plans for developing a national electronic clinical trials and research network that would eventually link community-based clinical systems with academic health centers throughout the country.
In addition to questions about topics that reflected members' individual interests - Duchenne muscular dystrophy, transient ischemic attacks, strokes, estrogen therapy, pancreatic cancer, and stem cell research - the hearing was characterized by questions and discussion about obesity and the need for a sound public health policy to promote healthy lifestyles. NCI's National 5 A Day for Better Health Program was cited as an example of a good public health initiative.
Rep. Nita Lowey (D-N.Y.) requested an update on the early detection and treatment of breast cancer. Dr. von Eschenbach described the latest methods to detect breast cancer, using nipple aspirants coupled with proteomics analysis to identify molecular signatures that will lead to the development of targeted therapies.
On the second day of hearings, Dr. Zerhouni, Dr. Allen Spiegel, director of the National Institute of Diabetes and Digestive and Kidney Diseases, and Dr. Story Landis, director of the National Institute of Neurological Disorders and Stroke, described the rationale and streamlining of decision making at NIH and how science is managed within NIH's institutes and centers.
Several subcommittee members asked questions about cancer. Rep. Rosa DeLauro (D-Conn.) expressed concern about the current level of funding for ovarian cancer research and SPOREs. Rep. Roger Wicker (R-Miss.) mentioned long-term cancer survivors and praised the work of Dr. Julia Rowland, director of NCI's Office of Cancer Survivorship. Rep. Jesse Jackson, Jr. (D-Ill.) inquired about the amount of money NIH spends on projects that address health disparities and minority health issues and expressed interest in how much NCI is spending in these areas. NIH is currently working on responding to Rep. Jackson's request.
Community Clinical Oncology Program
NCI invites domestic institutions to apply for cooperative agreements in response to this Community Clinical Oncology Program (CCOP) RFA. Applicants for new and currently funded CCOPs and research bases may respond. This reissuance of RFA-CA-04-008 seeks to build on the strength and success of the network over the past 20 years by continuing to support community participation in cancer treatment, prevention, and control clinical trials through research bases; expanding and strengthening the cancer prevention and control research effort; utilizing the CCOP network for conducting NCI-assisted cancer prevention and control research; and evaluating CCOP performance and impact in the community.
The RFA will use the NIH U10 award mechanism.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2040
Inquiries: Dr. Lori Minasian, email@example.com
Minority-Based Community Clinical Oncology Program
NCI is continuing the established cancer control effort involving oncologists who serve large minority populations in the NCI clinical trials program, providing a network of support for clinical research in cancer centers, major university centers, and community programs. Domestic institutions with the capability and intent to serve new cancer patients largely from minority populations are invited to apply for cooperative agreements in response to this Minority-Based Community Clinical Oncology Program (CCOP) Request for Applications (RFA). Currently funded Minority-Based CCOPs are also invited to respond.
This RFA will use the NIH U10 award mechanism.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2041
Inquiries: Dr. Worta McCaskill-Stevens, email@example.com
Support for Human Specimen Banking in NCI-Supported Cancer Clinical Trials
The purpose of this initiative is to support the infrastructure needed to ensure the collection of, storage of, and access to high-quality, well-annotated human specimens collected from and representative of the patient populations entered into NCI-funded, phase III clinical treatment trials.
The RFA will use the NIH U24 Cooperative Agreement award mechanism for Resource-Related Research Projects.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2043
Inquiries: Dr. Roger L. Aamodt, firstname.lastname@example.com
Community Networks to Reduce Cancer Health Disparities
NCI, through its Center to Reduce Cancer Health Disparities (CRCHD), invites cooperative agreement grant applications for Community Networks to Reduce Cancer Health Disparities Through Education, Research, and Training (Community Networks Program, CNP). The purpose of the CNP is to reduce cancer health disparities by conducting community-based participatory education, training, and research among racial/ethnic minorities and underserved populations. The overall goals of this program are to significantly improve access to and utilization of beneficial cancer interventions in communities with cancer health disparities, thereby reducing these disparities. This RFA is a reissue of RFA-CA-99-003.
The RFA will use the NIH cooperative agreement U01 award mechanism.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2042
Inquiries: Dr. Kenneth C. Chu, email@example.com
Paul Calabresi Award for Clinical Oncology (K12)
The purpose of the Paul Calabresi Award for Clinical Oncology is to increase the number of medical doctors and doctorally degreed nurses and basic scientists who are highly motivated and trained to: (1) perform clinical oncology therapeutic research; (2) design and test hypothesis-based, clinical therapeutic protocols; and (3) conduct cancer therapeutic research in team research settings to expedite the translation of basic research discoveries into patient-oriented therapeutic cancer research. This Program Announcement replaces PAR-03-083.
The PA will use the NIH Mentored Clinical Scientist Development K12 Program Award.
For more information see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=2020
Inquiries: Dr. Lester S. Gorelic, firstname.lastname@example.com
Workshop Results in Research Framework
NCI and NHGRI Host Tumor Sequencing Workshop
Participants highlighted recent discoveries such as work correlating EGFR somatic mutations with response to Iressa by Dr. Matt Meyerson's group at Dana-Farber (published in Science this week; see lead story), and research identifying mutational patterns that could help characterize new oncogenes from Dr. Victor Velculescu's laboratory at Johns Hopkins (Science 304:554). Attendees further emphasized the potential for tumor sequencing initiatives to stimulate new approaches for early cancer detection. Said Dr. Maynard Olson, University of Washington, "The enthusiastic dialogue at the workshop illustrates that we are transitioning to the next generation of genomic resources that will inform the development of novel cancer interventions."
Putting Science into Practice
In their article in the April 21 issue of the Journal of the National Cancer Institute, Dr. David A. Katz and his colleagues present the findings of the first randomized controlled trial to test the feasibility of implementing the smoking cessation guideline in primary care clinics and the effective behavioral counseling strategies in the guideline. The bottom line: It is feasible to use this guideline in primary care practice and its implementation leads to increased abstinence from smoking.
The Agency for Healthcare Research and Quality (AHRQ) is proud to have supported the development of the Smoking Cessation Clinical Practice Guideline in 1996 and, in 2000, to have been part of the consortium that developed its successor, the U.S. Public Health Service (PHS) Clinical Practice Guideline: Treating Tobacco Use and Dependence. However, we recognize that synthesizing the evidence is only the first step; we need to put this evidence into the hands of people who can use it immediately to change health and health care.
AHRQ's mission is "to improve the quality, safety, efficiency and effectiveness of health care for all Americans." We are working with public and private sector partners to translate the Guideline into improved health care practice. We also have developed a successful series of products and publications targeted to health care systems, clinicians, and consumers.
Our current partners include the American Cancer Society, Blue Cross and Blue Shield of California, the American Legacy Foundation, the Oregon State Health Division, and the Oklahoma Association of Optometric Physicians. As part of the National Partnership to Help Pregnant Smokers Quit, AHRQ has supported the implementation of the PHS guideline by prenatal care providers, resulting in quit rates of at least 30 percent among pregnant women.
AHRQ is building new partnerships with a variety of clinicians and organizations that directly influence care delivery. For example, AHRQ recently convened "Building Nursing Leadership in Tobacco Control," a historic meeting of 21 nursing organizations, representing almost a half million nurses. Nurses play a critical role in patient counseling and education, and we hope this will be the start of a broad-based effort by the nursing profession to support the implementation of cessation of tobacco use in clinical practice.
An essential component of strategies to promote smoking cessation is the identification of likely targets of opportunity. One AHRQ-supported study is evaluating rural emergency departments as an access point for teen smoking intervention, and another is studying smoking cessation interventions in maternal and child health clinics. Still other studies are examining physician profiling to increase smoking cessation, tailored outpatient nicotine replacement therapy, and evaluation of strategies to reduce smoking among Native American elders.
While effective smoking cessation efforts are, by definition, multipronged, primary care clinicians have important "teachable moments" with their patients. Moreover, patients who trust their primary care clinicians are far more likely to attempt lifestyle changes, including smoking cessation. Thus we are excited about our collaboration with the Robert Wood Johnson Foundation to help AHRQ-funded practice-based research networks (PBRNs) to develop creative, practical strategies for promoting healthy behaviors among patients that can be easily adopted by other primary care practices. The PBRN projects target the four health risk behaviors that represent the nation's leading causes of preventable disease, disability, health care burden, and premature death: tobacco use, sedentary lifestyle, unhealthy diet, and risky drinking.
Finally, in 2003, AHRQ's U.S. Preventive Services Task Force released a recommendation on counseling to prevent initial tobacco use that is consistent with the evidence in the PHS Clinical Practice Guideline. The Task Force's companion program, Put Prevention Into Practice, helps clinicians determine which services their patients should receive and makes it easier for patients to understand and keep track of their preventive care.
The PHS Clinical Practice Guideline on cessation of tobacco use provides evidence of what works, and with the Katz study we know that it can be implemented and lead to positive results. The imperative now is to identify effective incentives to sustain what works and spread successes across the nation to increase the number of Americans who successfully stop using tobacco. Please visit AHRQ's tobacco pathfinder Web site at www.ahrq.gov/path/tobacco.htm for a full menu of guideline tools.
Dr. Carolyn M. Clancy, Director, Agency


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COLUMBUS, Ohio (AP) -- Ohio House Democrats said Monday that key public promises made by Gov. John Kasich are absent from a bill authorizing the sale of $1.5 billion in Ohio Turnpike bonds to fund state highway projects, and they are taking steps to get them in writing.
The lawmakers said a bill released last week excluded a guarantee to keep 90 percent of the bond deal's proceeds in northern Ohio. The legislation also failed to mention Kasich's pledge to freeze toll rates for a decade for motorists making trips of 30 miles or less on the 241-mile toll road, which cuts across northern Ohio.
Democratic members of the budget-writing House Finance Committee said they have introduced amendments to place both provisions in the bill, for fear the administration could back out of the commitments otherwise. A hearing is scheduled Tuesday, with a committee vote possible Wednesday.
"You can't tell the people of Ohio one thing and then do something else, and think that members of the Legislature are going to be supportive of deceiving the public," said state Rep. John Carney of Columbus.
Ohio Department of Transportation spokesman Steve Faulkner says Kasich intends to keep his promises, but mandating an exact percentage of project dollars to go to one region or a certain toll policy could jeopardize flexibility.
"At the end of the day, those motorists and communities in northern Ohio are going to be so satisfied at getting those projects done," he said. "They're not going to care about a couple politicians in Columbus squabbling over a dollar figure or a percentage."
When Kasich rolled out his money-making plan for the turnpike in December, he said northern Ohio road projects would get priority treatment -- with almost all the money being directed to projects north of U.S. 30.
Going back to 2011, when the administration was exploring a private lease of the toll road, Kasich was expressing the same intention.
A 2011 administration fact sheet said "it is only fair that more than a majority of it go to the regions whose residents have supported the road the most over the years."
Beyond any fairness issue, the pledge was also viewed as necessary to securing political buy-in from communities along the turnpike that pay more tolls and rely on the roadway for jobs.
Many local government and business leaders who initially backed Kasich's plan made specific mention of either the money flowing back to northern Ohio or the toll freeze for local travelers in lending their support.
State Rep. Alicia Reece, the Finance Committee's ranking Democrat, said all Ohioans could see toll hikes under the bill's current language -- and northern Ohioans would feel the brunt of any increase.
State Rep. Kathleen Clyde said Monday that she expected debate to center on what constituted "northern Ohio," what percentage of revenue went to that area, and how communities neighboring the turnpike would establish the nexus needed to secure dollars for their projects.
Instead, she said, "When the bill was rolled out, there was no mention of the money being spent in northern Ohio."
Some House Democrats critical of Kasich's plan supported a 2008 proposal by then-Democratic Gov. Ted Strickland that would have diverted about $20 million a year in turnpike revenue to fund a $1.6 billion economic stimulus package. The plan, which ultimately failed, required the money to be used in transportation districts that surrounded the Turnpike.
State Rep. Matt Lundy, a critic of the Kasich plan who voted in favor of the 2008 package, cited significant differences in the two proposals.
"This is not the same thing,' he said.


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Donald in AZ
Not a matter if they will break but when they will break. I've been changing tires for a long time and followed stubby instructions and still broke them.Read All Reviews
Scott in UT
Trying to save the finish on my wheels and these help out a lot when swapping tires! No need to dish the extra cash for grips on them, they do fine. GOt gloves on anyway. lolRead All Reviews