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Targeted Therapy for Imatinib-Resistant GI Cancer Approved
On January 26, the Food and Drug Administration (FDA) approved the experimental drug sunitinib (Sutent) for treating an uncommon gastrointestinal cancer in patients who are resistant to or unable to take the primary treatment, imatinib (Gleevec).
Many patients with this cancer, gastrointestinal stromal tumor (GIST), become resistant to imatinib within 2 years.
Sunitinib is a targeted therapy that inhibits multiple proteins involved in the growth of cancer cells and the formation of blood vessels that supply tumors with nutrients, a process called angiogenesis. Read more
Guest Update by Dr. John E. Niederhuber
NCI's Intramural Program: A Cornerstone for Success
To the public, NCI is often thought of in terms of being the largest supporter of cancer research in the world. That is clearly one of NCI's most important functions. Perhaps the untold story, however, is the outstanding research being carried out by the talented scientists and clinicians in the institute's intramural program, the foundation of which entails the Center for Cancer Research (CCR) and the Division of Cancer Epidemiology and Genetics (DCEG).
NCI's intramural researchers perform essential basic, clinical, and epidemiologic research, upon which a great deal of extramural research is eventually based. Much of this work is rooted in multidisciplinary, collaborative science that takes advantage of the breadth and depth of the National Institutes of Health (NIH) research environment. In many cases, the research conducted by the intramural program is both high risk and high impact, involving complex investigations that offer tremendous promise conducted in the most thoughtful, rigorous fashion to ensure meaningful results. The intramural program also serves as the training ground for thousands of investigators launching their careers in science. Read more
Targeted Therapy for Imatinib-Resistant GI Cancer Approved
On January 26, the Food and Drug Administration (FDA) approved the experimental drug sunitinib (Sutent) for treating an uncommon gastrointestinal cancer in patients who are resistant to or unable to take the primary treatment, imatinib (Gleevec).
Many patients with this cancer, gastrointestinal stromal tumor (GIST), become resistant to imatinib within 2 years.
Sunitinib is a targeted therapy that inhibits multiple proteins involved in the growth of cancer cells and the formation of blood vessels that supply tumors with nutrients, a process called angiogenesis.
The drug was also approved for treating advanced renal cell carcinoma, a form of kidney cancer.
In granting approval for GIST, the FDA cited results from a randomized phase III clinical trial comparing sunitinib and placebo in more than 300 patients who had failed imatinib therapy.
The findings had been presented earlier that day at the 2006 Gastrointestinal Cancers Symposium in San Francisco.
The results show that the relative risk of death was reduced by half in the sunitinib group compared with the placebo group, and the time for cancers to progress was more than four times longer in the sunitinib group than in the placebo group.
Median overall survival has not yet been reached in this ongoing research study. The independent committee monitoring data during the trial made sunitinib available to all participants after interim results clearly favored the drug.
A small group of patients who could not take imatinib took sunitinib as a first-line treatment and had "excellent" responses, the researchers said. The drug, a capsule taken once daily, was generally well tolerated by patients.
Sunitinib, which was previously referred to by the code name SU11248, will be marketed by Pfizer. The drug is the first targeted therapy proven to be effective in a randomized trial after another targeted therapy failed, but others are being evaluated.
"We expect to see a lot more of these targeted therapies appearing in rapid succession," said Dr. George Demetri of the Dana-Farber Cancer Institute, who presented the findings in San Francisco.
He calls sunitinib a "multitargeted" therapy because in addition to blocking the KIT and PDGFRA proteins, which are targeted by imatinib, the new drug also inhibits multiple signaling proteins involved in angiogenesis and tumor growth.
To illustrate the drug's effectiveness, Dr. Demetri described a GIST patient who began taking sunitinib after imatinib failed. The patient's pain was relieved and the tumor stopped growing within a week, but it took 8 months of therapy for the tumor to shrink.
"The drug was shutting down the disease, but it did not shrink the tumor initially," Dr. Demetri said. Targeted therapies, he suggested, may increasingly help patients live longer "by controlling the disease even if they do not change the size of tumors."
The effects of these new therapies on tumors, he adds, can be seen with imaging technologies that are now used to develop targeted agents.
The development of sunitinib has been rapid. The drug was first taken by a patient with GIST in 2002 - just 4 years before FDA approval was announced.
By Edward R. Winstead
Guest Update by Dr. John E. Niederhuber
NCI's Intramural Program: A Cornerstone for Success
To the public, NCI is often thought of in terms of being the largest supporter of cancer research in the world. That is clearly one of NCI's most important functions. Perhaps the untold story, however, is the outstanding research being carried out by the talented scientists and clinicians in the institute's intramural program, the foundation of which entails the Center for Cancer Research (CCR) and the Division of Cancer Epidemiology and Genetics (DCEG).
NCI's intramural researchers perform essential basic, clinical, and epidemiologic research, upon which a great deal of extramural research is eventually based. Much of this work is rooted in multidisciplinary, collaborative science that takes advantage of the breadth and depth of the National Institutes of Health (NIH) research environment. In many cases, the research conducted by the intramural program is both high risk and high impact, involving complex investigations that offer tremendous promise conducted in the most thoughtful, rigorous fashion to ensure meaningful results. The intramural program also serves as the training ground for thousands of investigators launching their careers in science.
The history of the intramural program is marked by some of the seminal moments in cancer research history: the discovery of Li-Fraumeni syndrome, a genetic disorder found to predispose family members to multiple forms of cancer; the discovery of interleukin-2, which spearheaded the burgeoning field of immunotherapy; the early development of paclitaxel, the first natural product-based cancer drug; and the discoveries that clearly defined the central role of human papillomavirus (HPV) infection in cervical cancer, as well as the development of the underlying technology for the HPV vaccine that has demonstrated tremendous success in recent clinical trials, and the development of Highly Active Antiretroviral Therapy for HIV/AIDS. There are many others.
The important work of the intramural program continues. For example, as recently highlighted in the NCI Cancer Bulletin, CCR researchers have led the development of agents that inhibit a target called heat shock protein 90 (HSP90), which aids other proteins that play a critical role in the development and progression of many cancers. This work was based on the discovery that an off-patent antibiotic inhibited HSP90. It is unlikely that the commercial sector would have pursued this research because it was based on a nonproprietary compound. Now that HSP90 inhibition is showing promise, however, six other companies are developing their own proprietary agents.
CCR investigators also are on the cutting edge of imaging technology development to diagnose, monitor, and treat disease, and some are involved in conducting early-phase clinical trials in the NIH Clinical Center, where they often test promising agents or treatment approaches developed in their own laboratories.
DCEG researchers have joined forces with extramural investigators in the formation of cohort, case-control, and family-based consortia in a cost-efficient and coordinated effort to accelerate progress in the discovery of cancer susceptibility genes and their interaction with environmental factors. As part of this effort, DCEG has guided the Cancer Genetic Markers of Susceptibility study, or CGEMS, which is using the latest genetic technologies to perform dense whole genome scans with the initial goal of identifying and validating susceptibility genes for breast and prostate cancers.
The NCI intramural research program is an invaluable and unique asset of the cancer research community. NCI Cancer Bulletin readers can expect to learn more about the research being done in the intramural program over the next year. As cancer researchers continue to delve even deeper into the complex mechanisms of cancer initiation, development, and progression, and begin to develop intervention strategies, I believe the intramural program will only accelerate its role as a catalyst for progress.
Striking Discrepancies Seen in Smoking-Related Lung Cancer Risk
In one of the largest prospective studies of its kind, researchers from the University of Southern California (USC) Keck School of Medicine report significant racial and ethnic differences in smoking-related lung cancer risk.
In addition to the large size of the cohort, this new study, published in the January 26 New England Journal of Medicine, included far broader ethnic and racial representation than previous studies. It found that both African Americans and Native Hawaiians had significantly greater risks of lung cancer related to smoking compared with whites, Hispanics, and Japanese Americans.
National statistics have long documented significant differences in lung cancer incidence rates across populations, explains the study's principal investigator, Dr. Christopher Haiman, of the Keck Department of Preventive Medicine. And, he adds, it's well established that smoking behaviors also vary widely among these groups.
"In our study, among smokers we found quite striking racial and ethnic differences in the effect of smoking on lung cancer risk," he says, "and that these racial and ethnic differences were found to be modified by the number of cigarettes smoked per day."
To conduct the study, Dr. Haiman and colleagues from USC and the Cancer Research Center of Hawaii analyzed data on nearly 184,000 African American, Japanese American, Hispanic, Native Hawaiian, and white men and women in the Multiethnic Cohort Study (MCS). The NCI-funded MCS was established in Hawaii and Los Angeles beginning in 1993 to explore the relationship of diet and other lifestyle factors to cancer.
The analysis included 1,979 new cases of lung cancer diagnosed over an 8-year period. Among those who smoked 10 cigarettes or less a day, whites had a 55-percent lower risk of lung cancer than African Americans, and among those who smoked 11 to 20 cigarettes a day, a 43-percent lower risk. For Hispanics and Japanese Americans, the percentages were lower still. However, once smoking rates reached 30 cigarettes a day - the equivalent of a pack and a half - or more, the risk difference was minimal.
According to Dr. Mukesh Verma, acting chief of the NCI Analytic Epidemiology Research Branch (AERB), Epidemiology and Genetics Research Program, this latter finding could be because biologic or genetic mechanisms that modulate risk may have modest effects compared with the significant carcinogenic effect of heavy smoking.
The analysis ruled out differences in diet, occupation, and level of education as underlying factors to explain the risk disparities. Differences in education levels were related to risk but, the researchers argued, "Education is very likely a surrogate variable for other important exposures, but what these are and whether they are distributed disproportionately in the observed high-risk groups of African Americans and Native Hawaiians are not clear."
Research into the environmental factors that influence lung cancer risk across populations clearly is still necessary, says Dr. Verma. But, he adds, ongoing research as well as whole genome scans, such as those NCI has planned for breast and prostate cancer through the CGEMS study, may eventually pinpoint smoking-related lung cancer susceptibility genes that may help explain these ethnic differences.
The study's findings don't change the public health message on smoking, stresses Dr. Virginia Hartmuller, the AERB program director for the grant that funds MCS. "The bottom line is health care professionals should still tell their patients that they are far more likely to get lung cancer if they smoke, and they can reduce their risks by quitting."
By Carmen Phillips
Two companion studies, published in the February 1 Journal of the National Cancer Institute, examined whether outcomes after ovarian cancer surgery were influenced by the specialty training of the surgeon, or the number of procedures performed either by the surgeon or in the individual hospital. These NCI-sponsored studies were led by Drs. Deborah Schrag at Memorial Sloan-Kettering Cancer Center and Craig Earle at Dana-Farber Cancer Center, in collaboration with investigators at NCI and the Society of Gynecologic Oncologists. This study was stimulated by prior research indicating that some women with ovarian cancer are not receiving optimal care.
Both studies included women aged 65 or older with ovarian cancer who were reported to NCI's Surveillance, Epidemiology, and End Results registries between 1992 and 1999, and had available corresponding Medicare claims. One study focused on surgical specialty and utilized data on patients' sociodemographic characteristics, stage of disease, and comorbidities to assess whether evidenced-based care was received. Other outcomes assessed included surgical complications, short-term surgical mortality, and overall survival.
Patients were significantly more likely to receive evidenced-based care when treated by a gynecologic oncologist than by a gynecologist or general surgeon. Survival rates were higher among patients treated by a gynecologic oncologist or general gynecologist than by a general surgeon. The authors state, "Ovarian cancer patients treated by gynecologic oncologists had marginally better outcomes than those treated by general gynecologists and clearly superior outcomes compared with patients treated by general surgeons."
The second study examined whether the procedure volume of the surgeon or the associated hospital influenced outcomes. Measurements of outcomes included 60-day and 2-year postoperative mortality and overall survival.
Neither surgeon nor hospital procedure volume significantly influenced 60-day mortality although hospitals that performed higher volumes of procedures did have significantly lower 2-year mortality. The investigators concluded that neither hospital nor surgeon procedure volume was strongly associated with overall survival. These findings suggest that specialized training, more than surgeon volume, improved patient outcomes. The authors conclude that data from these two studies support that it is preferable for patients with ovarian cancer to be operated on by gynecologic oncologists when possible.
Methylation and Silencing of a Tumor-Suppressor Gene
While it is common knowledge that genetic mutations can lead to cancer, the importance of epigenetic events - chemical changes that affect gene expression - is now coming to the forefront of cancer research. DNA methylation is an epigenetic mechanism commonly involved in the control of gene expression and chromosome stability. Abnormal methylation of a gene can silence tumor suppressor genes or activate oncogenes, leading to tumor formation.
A study published in the January 24 Proceedings of the National Academy of Sciences identifies a probable tumor suppressor gene that is silenced when overmethylated, leading to aggressive cellular behavior. The investigators isolated this gene, TCF21, from patients with lung cancer, or with head and neck cancer. The gene is a transcription factor that plays an important role during embryogenesis, helping immature mesenchymal cells differentiate into mature epithelial cells. Investigators found a statistically significant difference in methylation of this gene between tumor and normal cells, both in samples taken from patients and in established cell lines.
When TCF21 was silenced, cells reverted to less differentiated behavior, including an increased ability for migration and increased cell division. Treatment of cell lines in which TCF21 was methylated and silenced with decitabine, a drug that can demethylate genes, reactivated TCF21. "Because this gene is silenced by DNA methylation," says first author Dr. Laura Smith, of Ohio State University, in an accompanying press release, "it might be possible to reactivate it using drugs that reverse the methylation process. This could provide a new strategy for treating these cancers."
Omega-3 Fatty Acids Unlikely to Prevent Cancer
An analysis of numerous, large population cohort studies did not detect evidence of a significant link between dietary intake of omega-3 fatty acids (found in fish) and the incidence of several major cancer types, according to a review study published in the January 25 Journal of the American Medical Association.
The reviewers analyzed 38 articles covering 20 population cohorts that included more than 700,000 individuals. The participants were studied for the effects of consuming omega-3 - either in fish, dietary supplements, or both - on the incidence of 11 different types of cancer, although more than half of the reports were for either breast, colorectal, or prostate cancers.
The combined studies provided 65 estimates of associations between omega-3 and cancer incidence, but "only 10 were statistically significant," reported the researchers led by Dr. Catherine H. MacLean with RAND Health. Significant associations between omega-3 fatty acid consumption and cancer risk were reported for breast, colorectal, lung, prostate, and skin cancers. "However, for breast, lung, and prostate cancer, there were significant associations for both increased risk and decreased risk and far more estimates that did not demonstrate any association," the researchers noted.
Across the cohorts, no trend was found linking omega-3 fatty acids with a reduced overall cancer risk. "Likewise, there is little to suggest that omega-3 fatty acids reduce the risk of any single type of cancer," the authors wrote.
Nasopharyngeal Meta-Analysis Shows Chemotherapy Works
Nasopharyngeal cancer (NPC) is rare in the United States and Western Europe, but endemic in many areas of the world (including China, Southeast Asia, North Africa and the Middle East), where it is strongly associated with the Epstein-Barr virus. Standard treatment for locally advanced disease is radiation therapy. While chemotherapy is often used as well, 11 large international trials failed to produce definitive evidence of additional benefit.
A meta-analysis using updated individual data from 1,753 patients in 8 of the trials confirmed that adding chemotherapy, especially during the course of radiation therapy, improved overall survival by 18 percent compared with those receiving radiation alone. Event-free survival improved by 24 percent.
Writing in the January 1 International Journal of Radiation Oncology·Biology· Physics, Dr. Bertrand Baujat, of the Institut Gustave-Roussy in Villejuif, France, and colleagues say the treatment effect is "small, but significant."
Cisplatin plus 5-fluouracil proved to be the best chemotherapy regimen, though the data demonstrating this were not uniform across all trials, nor as consistently strong for overall survival as for event-free survival. Subgroup analyses of those patients receiving chemotherapy before and after radiation therapy showed no significant advantage.
Treatment for Recurrent Head and Neck Cancer
Name of the Trial
Principal Investigator
Why is This Trial Important?
In this trial, researchers are randomly assigning patients with inoperable, recurrent head and neck cancer who were treated initially with radiotherapy to one of two types of treatment. One group will be treated with concurrent radiotherapy and chemotherapy, and the second group will be treated with chemotherapy alone.
"Chemotherapy is the current standard of care for locally recurrent, previously irradiated head and neck cancer, but such treatment is usually only palliative, not curative," said Dr. Wong. "Results from previous studies have suggested that better local control, and even long-term survival, may be achieved for some patients treated with both chemotherapy and re-irradiation.
"With this trial, we hope to establish the superiority of concurrent re-irradiation and chemotherapy for patients with recurrent head and neck cancer."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Interdisciplinary Research Consortium
Application Receipt Date: Dec. 19, 2006.
This funding opportunity will use the U54, R01, R21, competitive supplements, T90/R90, K01, R25, and P30 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3320. Inquiries: Dr. Greg Farber - email@example.com; Dr. Michael F. Huerta - firstname.lastname@example.com
Structural Biology of Membrane Proteins
Application Receipt Dates: Feb. 1, June 1, and Oct. 1, 2006; Feb. 1, June 1, and Oct. 1, 2007; Feb. 1, June 1, and Oct. 1, 2008; Feb. 1, 2009.
This is a renewal of PA-02-060. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3321. Inquiries: Dr. Peter C. Preusch - firstname.lastname@example.com; Dr. Jean Chin - firstname.lastname@example.com
PHS 2006-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications
Application Receipt Dates: April 1, Aug. 1, and Dec. 1, 2006.
This funding opportunity will use the R43 and R44 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3322. Inquiries: Michael Weingarten - firstname.lastname@example.com
PHS 2006-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications
Application Receipt Dates: April 1, Aug. 1, and Dec. 1, 2006.
This funding opportunity will use the R41 and R42 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3323. Inquiries: Michael Weingarten - firstname.lastname@example.com
Preapplication for Interdisciplinary Research Consortium
Letter of Intent Receipt Date: Mar. 21, 2006.
This funding opportunity will use the X02 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3324. Inquiries: Dr. Greg Farber - email@example.com; Dr. Michael Huerta - email@example.com
A large randomized trial of women who had completed treatment for early-stage breast cancer found that primary care physicians and cancer specialists provide follow-up care of equal quality, according to a study in an early online edition of the Journal of Clinical Oncology. The findings suggest that, in general, women who prefer to see their family physicians for follow-up care do not have to worry about decreased quality of life or an increased risk of a serious clinical event due to an undetected recurrence.
After treatment for early-stage breast cancer, women need regular follow-up visits to monitor their health and check for a recurrence. Follow-up care in most Western countries has traditionally been provided by cancer specialists (oncologists).
However, preliminary studies have suggested that patient satisfaction increases when follow-up care is handled by a primary care physician, with no reduction in quality of life or increase in time to diagnosis of recurrence. The authors designed the current study to address this question more definitively.
Nine hundred sixty-eight women who had completed chemotherapy or radiation therapy after surgery for early-stage breast cancer participated in the study at six regional cancer centers in Ontario, Canada. The women were randomly assigned to receive follow-up care from either a cancer center doctor or from their own family physician.
Participating family physicians received one-page guidelines that recommended the timing for follow-up visits and required tests. The investigators measured the incidence of recurrence-related serious clinical events in both groups and assessed health-related quality of life.
The study's lead author is Dr. Eva Grunfeld of the Dalhousie University Division of Medical Oncology in Halifax, Nova Scotia, Canada.
Participating women were followed for a median of 4.5 years after diagnosis, the period in which most relapses occur. No statistically significant differences were found between the two groups in either quality of life issues or the number of serious clinical events (for example, uncontrolled local recurrence or spinal cord compression).
In an accompanying editorial, Drs. James Khatcheressian and Thomas Smith, of the Massey Cancer Center of Virginia Commonwealth University in Richmond, write that the study "shows conclusively that the health outcomes for women after primary treatment of breast cancer are the same if they are followed by their family physicians or cancer center specialists."
The study's authors note that reliance on family physicians for follow-up breast cancer care is "likely to be more convenient…and potentially less costly" to the patient. However, they emphasize that if family physicians do assume more responsibility for follow-up care, the oncology community must make an effort to keep them informed about the most up-to-date standards of treatment.
Dr. Jo Anne Zujewski, a medical oncologist and breast cancer specialist with NCI's Cancer Therapy Evaluation Program, agrees with this sentiment: "If changes in practice do occur, the information needs to go out to primary physicians."
By Sharon Reynolds
World Cancer Day Focuses on Childhood Cancers
A new report on childhood cancers summarizes the progress that has been made in treating these diseases in recent decades, while also documenting the disparities that exist in cancer care for children around the world. The authors emphasize the need for parents to recognize signs of the disease and to seek medical treatment from trained professionals whenever possible.
The report, Childhood Cancer: Rising to the Challenge, will be released on February 4, which has been designated World Cancer Day. The International Union Against Cancer (UICC), a nongovernmental organization based in Geneva, produced the report and will make it available on their Web site.
On World Cancer Day, the UICC and its collaborators will focus attention on access to cancer care for children in developing countries and the critical importance of a proper diagnosis early in the disease.
"Knowing the common signs and symptoms of childhood cancer is one of the most important steps in fighting this disease and saving thousands of children's lives each year," says Isabel Mortara, executive director of the UICC. "Too many children are unnecessarily dying each year because they are not diagnosed or are diagnosed too late."
In the United States and Western Europe, the treatment of childhood cancers is a success story of modern medicine. Advances made since the 1960s, when there was little expectation that children with cancer would survive, have led to cure rates of 80 percent for many childhood tumors.
But the progress has exposed a huge divide between countries that are rich in resources and those that lack resources, notes Dr. Tim Eden of the International Society of Pediatric Oncology in the report's introduction.
"Of the children who develop leukemia and cancer, 80 percent live in poor or developing countries where in the face of other huge challenges - including starvation, drought, natural disasters, and infection - cancer is not yet considered a priority," Dr. Eden writes.
To address this issue, the UICC initiated a project last year entitled "My Child Matters." Money has been allocated to 14 projects in 10 low- and middle-income countries to increase awareness and improve the coordination of care and the training for professionals working with cancer in children. Sanofi-Aventis is funding about three-quarters of the projects, with the remainder funded by NCI.
"These projects will help communicate the message that childhood cancer can be treated and is often curable," says Dr. Franco Cavalli, Chair of the UICC Childhood Cancer Campaign Advisory Committee. The projects will occur in Bangladesh, Egypt, Honduras, Morocco, Philippines, Senegal, Tanzania, Ukraine, Venezuela, and Vietnam.
The report also discusses the social and cultural beliefs that determine how some parents in developing countries view cancer. For instance, families who feel they are being punished by their child's illness may not seek timely medical care or even follow prescribed medication.
"It is not enough to introduce Western-style medicine into a community while ignoring the social and cultural beliefs underlying attitudes towards the disease," the authors write. Acknowledging these beliefs will be critical to making advances in childhood cancer treatment more widely available around the world, they conclude.


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Morning DiscussionGood morning everyone, hope this Friday finds you well. Many people are still home with their families and such, so to call news slow is an understatement. Instead, you've pretty much just got me. So sorry. :( Results for the holiday contest should be up in a couple hours. My computer decided that maybe a dying hard drive would make things more fun, which I admit is pretty awesome!
So what are you guys playing this weekend? I'll give a Call of Duty 4 t-shirt randomly to someone who posts in the thread. Oh, and this gallery should populate itself with some good shacker creations over the next couple hours if you would like to take that in.
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subset: commoncrawl


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By Roop RajFOX 2 News
ANN ARBOR, Mich. (WJBK) -- A University of Michigan professor has put on his thinking cap to debunk a popular winter myth."I've done the research and I know that I don't need to wear a hat," says professor Andrew Maynard.Maynard, who works at Michigan's Risk Science Center, says the body does not lose a disproportionate amount of heat from the head. He created a YouTube video to highlight his point; hats aren't as necessary as you think."You look at the scientific literature and you realize that it's just not true," says Maynard. "You lose as much heat through your head as you do through any other exposed part of your body."Maynard says the 'hat myth' started in the military when a manual gave credence to the cap."The other part of this myth is this idea that if you're bald you've really got to wear a hat as well because your hair actually keeps some of the heat in. Actually, it doesn't do that much. You'd need a heck of a lot of hair to keep all that heat in," says Maynard.
1551 Briarcliff Rd., NEAtlanta, GA 30306Main Number: (404) 875-5555News Tips: (404) 898-0100


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Theories - Origin of LifeDiscussion of everything related to the Theory of Evolution.
Moderator: BioTeam
Re: Theories - Origin of Life
Didn't Luxorien say that mutagens facilitate the appearance of resistance? If that could be shown for various cases with various mutagens, I would take it to be strong evidence.
It depends on whether you're talking about mutations to the genotype or mutations to the phenotype.
Speciation is related to hybridization. According to the biological species concept, separate species cannot produce viable hybrids. Why does this definition work? I'll give the best explanation with my current understanding.
An hybrid is kind of like a junk-yard car with incompatible parts. If you're combining Toyota parts, you might get something that works. If you're combining Toyota and Nissan parts, you're less likely to get a working car.
Anti-evolutionists think that successive mutations can't result in new adaptations. In other words, the populations can't evolve new parts. I have never heard the following concepts from an anti-evolutionist, but I'm presuming this to be what follows. When a population is separated geographically, the separated populations shouldn't evolve their own unique sets of parts (assuming the anti-evo viewpoint). That is, even though they may diverge genetically, the blue-print for optimal functioning shouldn't change. Thus genetic divergence shouldn't result in reduced hybrid viability, and the populations should always have the potential to merge back together.
Again, this is just what is IMO what we should expect to see if the anti-evolutionists are right. We could easily test this by separating an insect population for some time, then observing hybrid viability.
I'm sorry for moving your post to the second-to-last page, especially since it is more on the topic.
Re: Theories - Origin of Life
Considering my metaphor further, I suppose the "∅ beneficial" viewpoint would still be compatible with the idea that the original population contained Toyota parts, Nissan parts, and an intermediate group of Niss-yota parts that were lost during speciation.
In that case, the initial population should show a wide range of hybrid viability, and the separated populations should not produce hyrbids that consistently fall below that range of viability. Of course, hybrid viability would have to be measured with respect to non-hybrid viability to control for any increase/decrease in harmful mutations.
Re: Theories - Origin of Life
Genotype. Change in phenotype is the result of the mutation. There can be no "mutations to the phenotype" by definition...
Re: Theories - Origin of Life
If you have hours of time to waste going back through this ridiculously long thread, I started out saying most mutations were neutral. Then he brought up studies on bacteria that talked about most mutations being harmful. Toward the end, I was attempting to argue that most random errors do cause problems, but cellular mechanisms correct those errors (or cause the resulting piece of DNA to be so broken that it isn't viable) so that by the time you are looking at phenotypes, most mutations are neutral because many of the most harmful ones have been weeded out.
If arguing with people on the internet helps me understand science, then I will do it. FOR THE CHILDREN.
crazy idea but, if u remember the miller and Urey experiment for origin of life, inorganic substances form the proteins. Does this mean that inorganic substances changed in form as time advanced in the young Earth???
Re: Theories - Origin of Life
The answer to the question of the meaning of life and the Universe and everything is 67: the number of unique phylogenetic types that exist in the Universe. See "An Introduction to the future of Science with the Paradigm of Types", which is located at http://home.spin.net.au/paradigm/ts.pdf
Later revelations showed that the Miller-Urey experiment didn't simulate early Earth correctly.
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Art Exhibits/Openings
Saturday TIME: 10:00 am to 5:00 pm
the original artwork of James Gurney, the author and illustrator of Dinotopia, an illustrated book series that tells the story of an island where humans and sentient dinosaurs live together in harmony.
On view through February 2, the exhibition brings together paintings from Gurney�s well-loved books A Land Apart From Time, The World Beneath, Journey to Chandara, and First Flight, along with sketches and maquettes from Gurney�s studio. Dinosaur specimens from the Yale Peabody Museum of Natural History, including a Deinonychus skull and a Tyrannosaurus tooth, will complement the paintings and illuminate the science behind Gurney�s art. Related events throughout the months
Lyman Allyn Art Museum
625 Williams Street
New London, CT
Members, free; 12 & under, free; adults, $8; seniors and students, $7
(860) 443-2545


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I had the please of being cared for by Jeff R. at you Scottsdale store. He gave me all the information needed to purchase a Laser Touch One unit which my wife and I are using with great relief. Thank you. Regards,
Jim L.
Just a quick note to let you know that Damien did a great job assisting our family in getting a hip high chair for our mother. He was polite, helpful and got the information that we needed. We finalized the order this morning with his assistance. Thanks
Xandis and Paris
Thank you very much. You are a superb example of what customer service should be. I appreciate your help and my sister is very happy.
David W.
Dear Ms. Stephens, last year about this time I purchased a Bella Vita bathtub lift for my parents. The lift is amazing and they have thoroughly enjoyed being able to bathe again, however, it broke. I called and got Josh, who promptly reported it to Drive Medical. Drive Medical contacted me the following day and within a few days, I had the replacement part. A couple days later, Josh called to make sure that Drive had contacted me, and assured me that I could probably change the back of the unit myself without having to resort to a repair person. Josh was right, the lift is fixed. Then I called Damien to see if I needed to return the old parts. Damien was so polite and looked up my file, then let me know I could discard the parts. These two young men are a credit to your company. I am impressed with the customer service that Active Forever provides, and wouldn't hesitate to recommend it to anyone looking for medical equipment. Additionally, I am impressed that Drive stands by their product with prompt replacement. You can be pleased with your vendor, but most of all with Josh and Damien. I commend them, and your company for hiring them.
Nancy O.
I wanted to give a special thanks to Damien Logan. I sent an email to the customer service address over the weekend. Damien responded early on Monday and has followed up wonderfully. I have an issue with my C2 vertebrae and the pillow helps me sleep without pain. The package arrived today. I couldn't be happier and am very thankful for Damien's help.
Mary T.
Thanks very much. I appreciate the way you guys took care of this. I'm sure we'll do business again. JD
I really appreciate your response and your honesty regarding your personal feelings re: your product and my intended use for it, although it lost you a sale. Thank you. I guess that I'll just keep using the straps as I have been, with a door. The company does sell wall anchors but my wife isn't too thrilled about holes in the walls. Plus, esthetically, they wouldn't look too good. Thanks again. Unfortunately it's rare nowadays to deal with honest people who would be willing to lose a sale in favor of their customer's safety. You can bet that I'll keep your address on file and purchase other products from you should the need arise. Have a great holiday. Michael K.
Really liked the service at @activeforever today, helping me buy my new shoulder pulley
Linda V.
Thank you very much Dorsey. You people are very good to work with. A typycal Amazon arm. Thanks again, warm regards
Gary T.
Thank you very much for all your help, Dorsey. You've been great. May you enjoy the weekend also.
All the best,
Sharron A.
Hello Victoria! You are fantastic!!!! You have definitely gone above and beyond. Thank you so much for all your help. Have a great day!
Best Regards,
Victoria, Thank you for your assistance. When I first inquired regarding the leaking cylinder, I was just hoping to get your advice regarding locating a suitable replacement and/or repair. I really appreciate you doing the research and expediting the warranty replacement so long after the sale. This is far beyond what I expected. Not only did I get the lift for a very reasonable cost, I got better after-sale service and support than had I purchased it locally. You have done both Ebay and the mobility equipment industry proud with your service and follow-though. Thank you.
Thank you, Victoria.
Nice to finally speak with you; you are so sweet, helpful and great at what you do. Tell your boss I believe you deserve a raise.
Just want you to know how much I appreciate you helping to solve this problem. The product was delivered successfully. Again, thank you.
Thanks for your help and the exceptional customer service, a rare thing in today's world.
Louise H.
Patricka, thank you so much, I really appreciate the stellar customer service!
Once again thank you for the great communication and fast replies. Hope to business with you in the future.
Have a nice day
Thank You Patricka!
You are awesome. First, for your professionalism, and secondly for your dedication to seeing this through. I'm impressed because this seems to be a lost art. Having someone competent and caring is a breathe of fresh air.
Bless your heart!
Dave E.
Just wanted to say thanks to Nathan @ ext. 173 for helping me with my order. I'm confident I'm gonna' really enjoy my new eWheels EW36 Electric Mobility Trike. The sooner it gets here the happier I'll be!!!
Michael Dohany
I ordered the Drive AGF-602 for my brother in law for Christmas and didn't think that it would be here in time for Christmas and it came today 12-21-2012 and I want to Thank you for getting it here on time to give to him for Christmas this is my third order with Active forever and I plan to make more purchases with you in the future and I will recommend your company to all of my friends Thanks again and have a Merry Christmas and a happy new year.
James Black
Dear Josh, I just wanted to drop you a quick note to thank you for totally handling a problem with a "Short Shipped PO" of mine. So often customer service is exactly the opposite and the customer has to keep following up on a problem that should be handled correctly the first time by the stores Customer Service Department. I can't tell you how wonderful it was to talk to someone as knowledgeable as yourself (without having to repeat my situation over and over) and have my order issue taken care of promptly and correctly.
I figured I probably wouldn't get my item prior to Christmas (which you promised) but I did, just as you said! Everything was perfect and it came exactly when you said it would. I just wanted to thank you for that and to wish you a very Merry Christmas and even better 2013. You are definitely an asset to Active Forever! I just wish I had your supervisors email address so I could send it to he/she. Since I don't, would you please forward a copy for me? Again, have a wonderful holiday season and thank you again!
Thank you very much! The Rollator arrived one day sooner than anticipated; and I needed it quickly for a doctor's appointment. It was exactly as advertised, and I just wanted to say how much I appreciated the excellent and FAST service. 5 Stars on all counts! Just a little note to let you know how we appreciate your excellence service!! Many blessings to you!!! Here's a pic of my Dad and I… he will be coming home on the 14th!! Yeah!! Victoria answered all of my questions and even gave me advice about my pop-up blocker, etc. My order is now in and paid!! -Paula Price via chat Dear activeforever,
You have given me great follow up and I appreciate it.
- favoritegeneral
Jenna, Thanks so much for your help. I now have you in my favorites list. I can't believe how many items you have. My interest is peaked especially since I'm a caregiver. Thanks again.Tammy P.
It want to thank you for the excellent service I received this week. First of all, it was WONDERFUL to be able to speak to a live person!!!!! Josh (I believe that is who took my call) was VERY helpful and efficient. I truly believe it is largely due to him that the product I ordered on Tuesday morning was delivered yesterday and is on its way tonight to Costa Rica, where a young man (21 yrs. old) desperately needs it to allay the effects of a tumor on the brain stem. THANK YOU!Lydia L.
Brad, This is such a great product. I am really enjoying myself. I can't believe how easy it was to set up and use. My husband and I are both retired and we intend to take it on the road with us in the RV. Right now we are using it in our backyard and it is wonderful. Even in the high winds we get here in the desert it maintains a temp of 102. I am sure if we put a gazebo or some other shelter around the spa or at least near it, it would maintain 104. What a good job. May you and your business prosper in this glorious New Year. God Bless America. And a Happy and Glorious to you, Brad, and your family.
P.S. the service was phenomenal. I ordered it on Monday and was sitting in it on Sunday. AWESOME! THANK YOU. THANK YOU. THANK YOU.From me and my family - Dayle
How can we ever thank you enough for your amazing response to our plea for help in getting the brace sooner? My e-mail was sent at 11:45am from Fayetteville, Ga., and imagine my surprise when a UPS truck arrived at our home at 4:45pm with the brace!! The extraordinary effort on the part of ActiveForever has touched our hearts. This kindness to our family is a testimonial to corporate values that are rare in today's marketplace. Please accept our heartfelt thanks. You made Veteran's day extra special for our family!Betty F.
Dear Erika,
Many times getting a repair for any piece of equipment is a harrowing experience. Thanks to the quality of your employee, Barry, that was not true this time.
In January of 2011, I found out I was to have my fifth hip replacement. I had been using the same single position lift chair for 10 years. It was worn out. I searched for a wall hugger due to the amount of room I had. Your company seemed to have what I needed. I had my surgery 2 weeks later, and to my surprise, I woke up without a hip because of infection. I lived in my chair day and night. It was not long before a spring poked a hole through the back of the chair. When my son checked the problem, he found that a spring had never been connected to the frame from the factory.
Thinking that I would have to give up my chair for a while and it would be an unpleasant experience to deal with, along with all the physical pain I was having, I waited. I have been a registered nurse for 40 years, and have, as I said, had many medical problems of my own. I was not looking forward to handling this situation.
To my surprise, it was not a bad experience at all. Barry was so kind and understanding. He helped me get the repair I needed for the chair, and followed up to make certain it was complete. I was to be out of town when the new back was to be delivered, it was held until my return, and Barry again followed up. Because of Barry's consideration, I will not be afraid to use your company again and will gladly recommend it.
Thank you for employing the kind of people that care!Sincrely Yours - B. Davis
I would just like to let you know that I had been experiencing problems with an over-bed table I had ordered and had been dealing with Dorsey Dollar in your Customer Service Dept. I would like to say she has been WONDERFUL!!!! Very caring and kept in touch and helped me with the problem. She is a wonderful asset to your company and great to deal with! :)Nadine K
I enjoyed the good customer service of your employee Mike this morning. Originally I wanted very much to order a Hydrohose, which is out of stock until October, and I told Mike when I did order the item it would be closer to spring, I'd have the money then and I would get two of them. He noted on my order today that I want to be notified when they are back on the sheles.
The rest of my order was small compared to bigger ticket items, but he stayed with me as I browsed support stockings and pill minders. He was surprised to learn that the two pill minders I bought today cost $20 apiece at a local drugstore.
Mike is the perfect man to have helping people place orders. "May I suggest this...?" he asked. Or, "Go to number XXXX. Is that what you mean?"
People do not usually take time to thank a n order clerk publicly, but I want to say "Thank You" to Mike and congratulations to ActiveForever on having such a fine representative.E. Brown - Whidbey Island, WA
Hi Tom,
The purpose of this email is to confirm my conversation with you regarding EVA, a customer service employee with your company. I had ordered a hernia truss that came thru in the wrong size on the confirmation and had paid for expedited shipping, due to the need to use it this Friday morning - a very recent muscle weakness. Eva listened completely to my story, made sure she had all the information of what happened and what was desired to correct the situation. She doubled checked to be sure the information was accurate. I was then informed she would work to do all she could to resolve the situation and would call me as soon as possible. This Eva accomplished and resolved the situation completely to my satisfaction.
I accept a certain range of positive and negative responses to me by todays business people. I respond when I experience excellent service by personnel and believe that they should be recognized for being exceptionally responsible. Eva was sincere, personal and professional. Her manner of working with me was very mature and came across as being very seasoned as a professional. However, her voice appeared quite young, thus I concluded that Eva has learned as well as intuitively understood a very successful approach with people.
I highly commend Eva for being an exceptional representative of your company. I will without hesitation continue to do business with ActiveForever as well as recommend your company and products to others. I believe employees need to be recognized and rewarded when their service goes beyond what I experience as a "norm." Eva responded to me and performed a service for me that did go well beyond this "norm."
Congratulations for having such an employee as Eva.
I also appreciate whatever part you had in this situation. A supervisor's position includes many skills.
Thank you.
Sincerely,J. Grant - Southbury, CT
To whom it may concern
I would like to thank you for outstanding customer service. I had been hunting around on the inter net trying to find a product that might help me with night sweats and hot flushes that have been making my life miserable. My apartment A/C does not cool my room enough and I have not had a decent nights sleep in ages, I found one of your products on line and I decided to call the customer service number to learn more about it. I was delighted with the way I was treated by Patricka Fletcher, not only did she give me more information on the product I called about, but she emailed me several other suggestions with the links to examine other items as well.
Patricka also helped me by explaining my Flex Spending could be used to pay for those items with my Dr approval. I contacted my Flex account and my physician and then came back today to order the items. While placing my order I told her about some issues with my back and legs and she suggested yet another of your products that will do exactly what I wanted, so I bought that too.
This has been an extremely easy and effortless transaction. Please pass on the highest compliments to her, she is an asset to your company and I will be a repeat customer because she was willing to listen to my needs and knew the exact products that would benefit me the most. Knowledgeable, caring, competent personal service makes all the difference. I do hope you will recognize her Customer Service skills and product awareness. I am really looking forward to receiving the items I have ordered with the help and information I received from Patricka.
Sincere ThanksR. Walker
I would like to let you know how great Patrika is (not sure how to spell her name). Extremely courteous and very friendly (she has a smile in her tone).
I received my product yesterday and unfortunately it was defective. I called to let your company know and Patrika was fabulous! She really took care of me and made sure that another one was sent right out to me.
I have been in the retail industry for 30 years so I know what great customer service is.
Thank you for a great experience. I will shop with your company again.
Best Regards,K. Ogden
I am a new customer. I found an item thru the internet to your site. I wasn't sure if the item would work for me. I contacted your customer service department and with in minutes they answered all my questions. You have the BEST customer service department that I have ever seen. I have contacted several other sites and still no response from them. I will be back for more items later. Please keep up the good work.K. Motes - Smyrna, GA
I just wanted to write and tell you that the service I received from Aaron Serbu and all the other individuals that I spoke with, were some of the most polite, helpful people I have done business with. I wish I would have wrote each persons name down so that they could receive credit, but I want to thank each one of them for their help.T. Earls - Avenal, CA
Please send me as many catalogs as you can. I work primarily with Parkinson's patients, but also oversee the resource center at the Covenant NeuroScience Institute. We house neuro rehab for the hospital as well as housing the following nonprofit organizations: National MS Association, Epilepsy Association, Parkinson's disease Assoc., Alzheimers Association and soon will be adding the ALS Assoc. We all service large areas in West Texas and Eastern New Mexico, with support groups, etc. Having resources where patients can order medical equipment at discounted prices would be wonderful!J. Bidwell - Lubbock, TX
Just to let you know, my mother loves her Gel Pro Chef's Mats! She is 80 years old, Italian and loves to cook!She said, "You should get one" then she said, "Wait, you don't like to cook !" She knows me as well as I know her !
Thanks again!T. Kutch
There's a reason why y'all get such high ratings! Thanks for the great customer service, Krista. That's a rarity, especially around Christmas. Appreciate it! We did get the items just as you promised.
Merry Christmas!Susan
Dear Erika,
I just wanted to dash off a quick email to compliment you on your customer service.
i retired from the practice of law in the public sector and now work full time in a floor heating company. most of what i do now is related to marketing and i have done a ton of research on what it means to be customer centric. and i must say, from what i have observed regarding the handling of this issue, your company is the epitome of customer centricity.
thank you for all of your email correspondence and i look forward to trying this product.
Warmly yours,vickie
You ladies are great. I have told Patricka this in the past, but I mean it, it is a pleasure to do business with professionals who take care of business, but also take time to make it fun. I look forward to the next visit.
Best always.John
I want to pay my compliments to your company for the excellent customer service that my wife received to day when she called to track an order. She was amazed that she was able to conduct her business in a timely and efficient manner with a young man by the name of Mike. He was able to help her with her problem in a matter of minutes.
Please do not ever outsource you customer service. Because when you have to deal with companies that outsource their customer service it leaves a very bad taste in your mouth.
We have had bad experiences with HP and Charter communications when conducting business. Because of their outsourcing Customer service. Therefore we will not look to purchases HP products in the future. With Charter Communications I have no choice.
Because of you excellent customer service. I will use your company again in the future and also refer other people to your siite.Thank you James C.
Dear Erika,
Duncan and I can't begin to adequately thank you and your incredible team for all the recent assistance provided to us with regard to his malfunctioning scooter.
Certainly we agree with you that Mary Jo gets special credit - she made it happen - but each of you went so far above and beyond that we are more grateful than you might imagine. And the house is nice and quiet, too!
Active Forever is all it deserves to be, in that you're well-known and highly-regarded throughout the area with good reason: you personify the service ethic...the 'customer always comes first' ethic. Further, there must be a reason we nearly never leave the shop without buying something: there's always some item that we've not yet thought about that we suddenly realize can make Duncan's life easier in small and big ways.
Thank you, thank you, thank you - for running a business you should be immensely proud of, with a staff you should be immensely proud of. We are the very lucky beneficiaries of that.
Warmest regards,Elaine & Duncan
Thank you, it's nice to deal with a company that responds so promptly...makes the customer's job much easier.KMyers - Chico, CA
Much appreciation
Dear Ms. Feinberg:
I am writing to tell you of an experience that I had with your company, and in particular, Ms. Householder, within the last 24 hours, that completely changed my view of internet shopping. My mother had an unfortunate accident in her home late Wednesday evening, and broke her arm. Clearly, we were in need of some help in order for her to adequately cope with day to day tasks as simple as getting out of a chair, due to the inability to use her arm. After returning with her from the doctor late Thursday afternoon, I decided to get her some help, and noticed a device, the UpEasy Chair Cushion, that I thought could be of assistance. After reviewing a number of websites, it seemed like your pricing was quite reasonable. I placed my order, and due to the urgency of the need for it, I ordered it via next day shipping. When I called customer service at shop.com, I was told that it was too late to receive it tomorrow. The significant cost of this shipping was never the issue - - it was the immediate need of the item that was of paramount importance. This is when I had the wonderful fortune of dealing with Ms. Householder.
I left a voicemail for her, which she promptly returned. With great sincerity, a true willingness to help, and most importantly - - - the utmost compassion for my mother's situation, she swung into action. She contacted the manufacturer directly, arranged for alternate shipping instructions, called me back, and lo and behold, my mother was in receipt of the device by 10:30 the next morning!!!! All this, simply put, because someone took the time to do something that is so often overlooked - - - - she simply cared. Although we have never met, and our contact was limited to a couple of short phone conversations and e-mails, it is quite reassuring to know that there are Stacy Householders out there. So in the end, some anonymous points and clicks of the mouse turned out to be a true human interest story - - by that I mean one terrific young woman took the time to have some basic human interest in someone that she has never met, that is old enough to be her grandmother. Ms. Feinberg, please be aware of what a great asset Ms. Householder is to your organization. For one family in New Jersey, she redefined what the term "customer service" is all about. For those in need of products you sell, I will never hesitate to recommend www.activeforever.com, and if they run into some trouble, I'll tell them to "just ask for Stacy."Marshall K.
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At EZSolution our website development staff knows that just about anyone can offer web design services. All you need is a few basic tools and just enough knowledge to be dangerous. But the truth is that successful website design is about much more than putting some words and pictures together on a page. There are many local website design companies in Lancaster, Harrisburg and York that are great at the design part of web design. They'll blow you away with their fancy graphics, video presentations and color schemes. But when it comes to tapping into the true marketing potential of your website, they just don't get it.
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STAFF DIRECTORYThe Office of Co-op and Career Services is comprised of people who are very focused on providing quality service to students, employers, parents, faculty, and prospective students.
Program coordinators, assistant, and associate directors are aligned with particular academic programs. (If you are interested in contacting someone who supports a particular major, select one of the program areas on the left).
Results by Major:
Lisa Vasaturo
Career Services Coordinator
(585) 475-5460
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Career Services Coordinator
(585) 475-5460
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Bridget, I am SO happy for you! The urologist at least seems caring and concerned, and I'm sure will help you get to the bottom of this.
I've done so much public speaking that I've become completely used to it. As long as I am well informed, I tend to do well.


text:
Show that someone special how much you care with these super sweet ideas for homemade Valentine's Day cards, crafts, and gifts. Find a lovely idea for a classroom activity or a unique gift for a one-of-a-kind person.
These arrows from Cupid's quiver may not have any supernatural effects, but that doesn't make them any less fun to share.
Your kid will be a hero when he hands out these supertreats.
This bit of treat trickery starts with a photo shoot.
Go ahead: give a diamond ring to every kid in class!
Go wild with these jungle-toy cards.
Mad Libs, with their elements of nonsense and the occasional (and purely accidental, we're sure) off-color joke, are a perennial hit with kids.
Your preschooler can say, "I'm sew glad we're friends!" with a card that doubles as a sweet lacing toy for your child's valentine.
These whimsical white chocolate confections -- perfect for Valentine's Day gifts or party favors -- can be eaten right off the spoon or stirred into cups of hot cocoa.
Sweet valentines that are a cinch to make with this great Valentine's craft from Spoonful.com.
When the urge to wax romantic strikes, these melted-crayon valentines really fit the bill.
Sometimes, simplicity really is best, as these crowd-pleasing valentines demonstrate with their perfect pairings of message and treat.
These adorable little robots are programmed to transmit Valentine's Day messages -- and treats.
Make the perfect Valentine to give to pint-size suckers
Surprise your honey with a lollipop-toting bumblebee.
All Aquiver
Caped Cute-sader
Ginormous Lollipop
Let Friendship Ring
Animal Attractions
Mad Love
Lace-y Valentine
Lovin' Spoonfuls
Gnome Sweet Gnome Valentine
Stained Glass Heart Valentine
Perfect Pairings
Treat Transmitters
Valentine Mice
Bee Mine Valentine
You might also like


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I think having another child after HELLP syndrome is a difficult issue for anyone who's been through it. I am lucky in that I didn't notice any symptoms with my first pregnancy until after my c-section, and I made it to 38 weeks. My son was small (5 lbs. 8 oz.) because of IUGR related to HELLP, but otherwise healthy. Like you've experienced with your daughter, my son is truly the love of my life. My husband and I also have different views about whether to have another child. I would really like to have one. I am an only child, and I always wanted a sibling when I was little, so I never wanted to have just one kid in part because of that. My husband and I had both agreed before we got married that we wanted to have two kids, and I would still like to have two. My DH is more hesitant. He is not much of a risktaker, particularly when it comes to health issues. But it is very difficult for me to think we might be "one and done." It is not an easy decision. I wish you luck and peace with whatever choice you make.
Also, I know celiac can be difficult to deal with, too. My DH has celiac and there is a strong history of it in his family. Luckily, our DS does not have the genetic markers for celiac. But still, we are a gluten-free family. It is not easy, especially when you're newly diagnosed.


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One of the robbery suspects involved in a Wednesday morning armed robbery at an east Tyler gas station is in custody.
Around 4:40 a.m., the Exxon/ Food Fast gas station at University Boulevard and Old Omen road was held up, according to police.
Officers said two unidentified black men with handguns entered the store, but realized the clerk was outside smoking. The worker was forced back into the store and the men got away with cash from the register and fled into a wooded area behind the store, according to investigators.
The worker and another store customer were unharmed in the robbery.
Upon searching the area behind the store with a police K-9 they located one of the suspects lying in the wooded area who had been shot in the lower right leg. Officers located a gun and other evidence linking him to the robbery.
The suspect was identified as Jaqun Jamel Dawson, 18, of Dallas, Texas. Dawson was transported to a local hospital and was treated for his injury. Investigators will be seeking an arrest warrant for Aggravated Robbery on Dawson today.
Officers set up a perimeter, but were not able to locate the second suspect after several hours of searching.
The University of Texas at Tyler has issued an advisory for students, faculty, and staff. The email said there is no indication the suspect is on campus. According to a University news release, "The only description of the subject at this time is a black male, approximately 5 wearing dark clothing and some type of black hat."
Wednesday morning classes will not be affected by the incident.
At 7:40 a.m. UT Tyler issued a "Patriot Alert" text message to students, stating that the active manhunt had ended but law enforcement were still pursuing the second suspect.
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A large helicopter crashed last month near Norfolk, Va., and not only wasn't the National Transportation Safety Board mobilized; it probably even had advance warning. The planned wreck was part of a continuing series of rotorcraft crash tests sponsored by NASA in partnership with the FAA, the U.S. Navy and the U.S. Army, dating back to 2009.
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When my wife and I recently dropped off our son for his freshman year at Bard College, we had the pleasure of listening to a talk by the school's extraordinary longtime president, Leon Botstein. He noted that universities have been around since the 11th century and have endured through everything from the development of movable type to the invention of electric lights and the moon landing. They'll survive the Internet, too, he said.
FAA enforcement cases tend to focus on the front-line employees, usually pilots or mechanics, who allegedly violate federal aviation regulations. Occasionally other certified airmen, such as aircraft dispatchers, parachute riggers or air traffic controllers at contract towers, face enforcement action.
A year ago, Laminar Research, the maker of the popular X-Plane flight simulator software, was sued by a company called Uniloc, which accused Laminar Research of infringing a Uniloc patent entitled "System and method for preventing unauthorized access to electronic data." Uniloc is seeking a jury trial and wants agreement that its patent has been infringed, payment for damages and costs, post-judgment royalties and pre- and post-judgment interest.
A little over a decade ago, my wife and I had at least some small chance of becoming rich beyond belief. We were among the first investors in a technology startup that had the potential to be as revolutionary and widely adopted as the iPhone or iPad, and with even greater revenue. Unfortunately, the company's digital-wallet concept was ahead of its time and the founders, despite diligent efforts, lacked the muscle to make it a reality.
Whistleblowers have been in the news a lot lately: Edward Snowden, the NSA leaker who some call a whistleblower; Avantair's whistleblower-initiated shutdown; and the latest TWA 800 conspiracy theorists (who also style themselves as whistleblowers, although 13 years after the NTSB's probable-cause report was issued seems more like a whistle-whisperer than -blower)–the
I was reminded of the wonderfulness of the Paris Air Show on my last day at Le Bourget Airport on June 20. My job at most shows that we cover is tied up with producing AIN's daily issues, and for two or three days before the show until the night before our last issue is printed I'm heads-down in the constant struggle to stay ahead of the relentless deadlines involved in producing a daily print magazine.
I've always been one to deliberate carefully before spending money, but I might not have labeled myself an obsessive shopper until the day, several years ago, when I went looking for a new kitchen faucet.
For a time in the 1970s and 1980s, Wisconsin Sen. William Proxmire gave out his Golden Fleece Awards. But they had nothing to do with Jason and Argonauts.
I remember well that night 17 years ago when TWA Flight 800 exploded and crashed off the coast of Long Island, killing all aboard. I was settling down with some friends at my brother's Manhattan apartment to watch a game between the Red Sox and their arch-rival Yankees when the game broadcast was interrupted by news that an airliner had crashed soon after takeoff from JFK International.


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NEW YORK Rare earth metals are likely to see a major boost in demand as a result of increasing applications in the automotive sector, according to Quest Rare Minerals Ltd.s top executive.
"Every motor you can think ofwindshield washer, power window operator, motors that open up your trunkthose are all inputs of rare earths. Now, consumers expect these gadgets and those luxuries that are standard in vehicles as consumers expect them as commonplace," Peter Cashin, president and chief executive officer of the Montreal-based rare earths exploration company, told AMM.....
NEW YORK Rare earth metals are likely to see a major boost in demand as a result of increasing applications in the automotive sector, according to Quest Rare Minerals Ltd.s top executive.
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Are you stocking more inventory today than 18 months ago?
We actually don't know who his investors are. At the point when we are ready, we will investigate further. There are just so many things to handle and there are a lot of items to be considered with the project."
-- Charles C. Mitchell, Barstow city manager


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Oh Bridget That makes perfect sense to me why it would feel like losing her again. Maybe he was just talking out loud but doesn't really have any solid plan right now.
Hi, Bridget! Missed you! I totally understand about the smell of the house.
Lydia, that is the sweetest thing about the twins. This is a tangent, but I remember trying to explain to my niece that I was their mommy's sister and their grandma's daughter. My niece didn't like that - grandma was HER grandma and mom was HER mom. She didn't like other people having different relationships.
I know I must say this constantly, but I forsee doom at work next year. They are playing stupid, stupid games that don't even save them money. They are cutting the people in my position in half by eliminating the outside contractors, while increasing our caseloads (well, firing 50 people will save them money). We were informed today that they were extending the hours we were expected to work and eliminating paid lunches. We're on salary - we're not paid by the hour. And we all work WAY more than 40 hours per week including paperwork time. The children are in school 6 hours per day regardless of when we work, so increasing our hours won't increase direct service time. And all the teachers have the same contract hours district wide (37.5 hours with .5 hour lunch included). Everyone takes home work, it's part of being a professional. They are going to take us off the union contract hours while we remain subject to the union concensus agreement? And my DH says he has never heard of a salaried employee not getting "paid" through lunch time. It makes no sense. I can't even see how it would save them money - we're already working those hours and more and will have no more time in which to provide services to the students! One coworker suggested that if we are being expected to work 40 hours, than we'll work 40 hours. And cut our working time by 1/3! I think that's the plan. If they want hourly employees, that's what they'll get. It's just insulting.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
Oh Mandy, I hate that they're doing that. How awful! Even being an outside person looking in, I can't see how this is going to help anyone. The kids won't be served, the workers won't be served, and as employers they're not going to be served. It's going to cause a lot of stress and negative vibe at work for a lot of people.
Exactly! What does it get them other than to piss us all off?
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
No, I don't think they will. They'll find they'll lose a lot more than the 50 contractors they planned to let go. And they won't able to hire those people to replace the employees that quit because the contractors all have noncompete agreements.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
That doesn't make sense at all. Sometimes you wonder how people got into management.
Check the labor laws in your state....I don't know how you can call someone salaried and do unpaid lunches. It doesn't make sense at all. I don't see why they would hourly instead....you get so much more work out of someone that is salaried....no overtime.
I think that is a symptom of the economic plummet we just had...many businesses and now public sector jobs are cutting and slashing all over the place. KimJ worked the same place for 3 or maybe even 4 years without a raise. Teachers and unions and anything associated with children services are being cut. It's truly frustrating. I don't know how they cannot see that this is going to have a snowball effect. Those we don't take care of now will have larger challenges and be a bigger 'burden' on society as they become adults.
I've read a few articles that claim things are looking up, and the trend will now be that workers will look elsewhere if their current employer doesn't reward them properly. It's not all about the money, either. When they pull stuff like this, it creates stress and negative workplace energy. The days of being grateful you have a job are going to end, and people will start looking to see what's out there.
Since we are on the topic of jobs...
Mine is getting ridiculous. People are taking things WAY too seriously, and it is NOT a positive environment. No one wants to be there, and you can feel the tension the second you walk in the door. No respect is given to any of the employees, and I have to remind myself, and a few others daily that "Its just a retail job"
So I talked to my mom and dad about taking the summer off, especially since I am taking that CNA class that will be mon-fri 8-5. I would have to work 5:30 - Close, and weekends which would give me NO study time. I am also taking a US History class online.
They kinda laughed at me and said "We told you to quit a LONG time ago!!"
So looks like I just get to be a student/mommy this summer, and I am SO excited!
That's awesome, Ash! I'm glad you have supportive parents; that helps so much.
I have job related news, too! I'm not going back to my old job after my 1 year maternity leave is up in August. I'm going to be volunteering at a local elementary school and applying to do a graduate course to get back in to elementary school teaching! I'm so excited! (And of course, I'll be spending time with my boys while not volunteering so it's a win-win situation!)
For me, I'm leaving tomorrow for the Medical Library Association's annual conference....the national meeting is in Minneapolis this year so my boss and I are going. (last year it was in Hawaii which was NOT in our budget and next year is Seattle which probably won't be either). I hope to have internet in my room but that is uncertain if it's going to be free. I will be back home later on Tuesday. It should be pretty good. Last one I went to was in Chicago four years ago and I learned so much at that one.
I got some groceries last night and tonight I'm making a lasagna and tomorrow morning probably a mac and cheese. That should give DH some food for him and Cosmo for most of the time I'm gone and they can eat out if needed.
I was a bit surprised....but again I wasn't. At this point all left have talent and it comes down to personal taste and country is so big in this country. I liked him but I have to admit that I didn't like all he did and often (especially this week) seemed out of tune a bit. Like the journey song was alright....but not compared to Glee's version.
My top choice is Haley....going to have to start voting.
And I love Gaga (now there is some talent!)....and Scotty needing to kiss his cross
I Lady Gaga. Scotty cracked me up...I sometimes forget how sheltered some people can be, and I think his reaction to Lady Gaga is just a symptom of that. I like Scotty's singing, but I loved James a helluva lot more.
Here's to hoping your gopher sticks work!!
Lydia, your story about Claire telling a stranger about her sister made me so teary for some reason. She has such a sweet, beautiful mind. I imagine she is going to have a piece of Esme living inside her all throughout her life.
Ash, lucky you for getting to be a student/mommy this summer. And your girls are lucky too for getting more of you.
Jennifer, safe travels to your conference!
Mandy, I am so sorry that your work is heaping all that worry on you. Are you thinking at all about alternative work? It seems as though there are 2 gaps to fill - the smart and talented people on your job are left feeling very dissatisfied, and the children are left with a lower quality of care. I wonder if there's anything that you and your colleagues who feel the same way can do on your own to fill both of those gaps. Hang in there, girl!
As for me, my boss told me that the project I've worked to design the last couple months is underfunded, and they're going to try to "slow it down". It didn't hit me until I was folding laundry last night that it could mean my position going away as well. No boss has ever shared so much about her budget with me, so yesterday I learned that my pay is roughly 5% of her budget the rest of the year. I won't have as much to do if there's no money to build as big a feature as the one I designed. And the rest of the full-time team will have less to do because of the slow-down as well, so they could probably take over where I leave off. I usually have a good intuition about when my contract is on the chopping block. So I'm going to update my resume today and shop it around a bit.
I have my eye on just one company - Virgin America. I live pretty near the offices, and I've always wanted to work in the airline industry (travel benefits!). This is going to sound really hokey, but in the past, I've set my sights on different workplaces I liked and sort of visualized working there/meditated on them/sent them my vibes of intent. It worked to get me a contract at Toyota that lasted 2 years. So who knows? It could be really, really cool, anyway.
Bridget, I hope that there's some way you can preserve a piece of your mother from your childhood home even if your father sells it. Perhaps the sale of that house is another step on your journey to finding peace with your mother's passing. I think sometimes that the perception of grief is that is has to happen on some sort of a timeline - like it's some sort of visitor that comes and then has to go away by such and such a deadline. I think, instead, that perhaps the loss of a loved one is a "visitor" that stays forever and becomes a part of ourselves. And it could take years for you to become comfortable and welcoming towards your guest. Everything you're feeling is perfectly valid and makes you the lovable soul you are. I hope you do find your version of peace with your mother's passing in good and perfect time.
I feel stuck in my job. Not many appear that I'm qualified to do in the IT field, and there have been (and continue to be) cuts, so there's real competition for the slim ones that come along. There are very few places in the area that offer the pay and benefits Cornell offers, so looking elsewhere is practically a waste of time (although I do look).
I also feel like I should be expanding my expertise, but I'm really struggling with what direction to go in.
Ashley, yay for being a student/mommy for the summer!
Ashley, yay for back to school and volunteering!
As Idol goes, not happy at all. Although I agree he was off key this week, still not happy.
Second, since my employer is letting go 50 employees there will be a glut of people with similar qualifications who are looking for work. Still, I'm in a high-demand field and I love the idea of working for myself, but taking on the issues of finding clients, getting reimbursed by insurance companies etc with my husband out of work is just too much of a risk. Another aspect is that currently I'm in the business of providing services that are federally mandated and free to my client. Taking on providing those services for pay means my client base narrows right away, even if it's covered by insurance. Not everyone has insurance as we all sadly realize, and in this economy it's even worse.
It's sad though, because as Chrissy said, if we don't pay for supporting the kids now we'll pay for it later (and more) through welfare or the jail system. I'd much rather support preschoolers than prisoners but seems like no one in the government "gets" that.
I told DH I think we should move now if he's thinking about moving. But we don't have all the information yet about that Georgia job.
And Myles, I hope your visualization strategy works for you. Of course, I hope you don't need it, but you might be ready for a change anyway.
Last edited by Gwenn; 05-13-2011 at 06:14 PM.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
If I visualize well behaved teens, do you think I'd have them? I'm only 1/2 kidding...Jesi pulled her "i'm not coming home tonight" crap again. I called her unapproved-of bf right up and laid the law down. He met me with her at a bank parking lot in less than an hour.
Again, I told her that she can't go anywhere because she keeps getting in trouble like this. If she wants to go spend the night with her friends, then she has to follow the rules. I had just been thinking about inviting the unapproved-of bf over for bbq's and bon fires this summer...at least as a way of keeping her happy, but also keeping an eye on him at the same time. Trust is earned & all that.
I feel like I'm winning the most unpopular mother of the year award right now. Poor Sydney was itching to go to Owego (about 30 minutes away) and just walk in downtown like we used to. Of course we couldn't because Jesi wasn't home and we were preoccupied with that. So Sydney gets irritable and I can totally understand why.
I hate that she keeps putting you through all this, Chrissy. It's hard to give her the positives when she keeps ignoring the rules.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
What a crap night I had. I dpn't know if it is because dbf was having some drinks or what but he was being so unreasonable! After we got the kids to bed he put in a movie. I was reading my book and he went off on me for reading because A) It's horrible to watch a movie with the light on B)I never pay any attention to him and it's just so terrible that I won't put my book down and watch a movie with him. Oh, and he's angry that I fall asleep almost every time we watch a movie. Then when I responded in anger and disbelief that he was speaking to me that wat he said that I'm mean for not apologizing to him for making him feel ignored.
Okay. I do not respond well to over dramatized accusations like "you never" nor do I respond well to being told how I am supposed to react to his rantings. I get very defensive and offended.
And I am sorry but I am effing tired and would rather get a few hours of sleep than force myself to watch and pretend to be interested in movies every night of the week. It's 5:30am on a saturday and I'm up feeding Sawyer for the 4th time since I fell asleep around 10pm.
I just wish he could be a mature enough man to approach me calm and sober if he has issues with me. He ruined my whole night.


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Thursday: Not a whole lot of change in the forecast. Fog and Freezing fog possible this morning, with partly cloudy skies this afternoon. Likely see a few light showers across the northern counties. High: 33°
Thursday Night: Again expecting mostly clear skies overnight, but as it clears, temps cool down and the fog starts to set back in again. Low: 22°
Friday: More fog to start the morning (as to be expected with inversions in place). Increasing clouds into the afternoon and by the evening a weak cold front expected to cross over us and bring a slight chance of anything from rain, freezing rain, rain/snow mix or light snow depending on temperatures and elevation. High: 34°


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Loving my Accord - I bought my EX-L 4 cyl. CVT 3 months ago. The more time I spend with it the more I love it. Everything about it is effortless -- it drives well, it's ...Read Full Review
Sport Manual Rocks! - I bought a 2013 Accord with the 6 speed manual and it's fantastic. It drives with precision, yet isn't twitchy. the manual is just one of the best I'v...Read Full Review
instrument display problems - Picked up my ex-l on Monday,everything was as good as Honda advertized, EXCEPT for the instrument display daytime brightness.the dealer salesman and t...Read Full Review
Horrible milage - The car itself is a fun car to drive. Looks and drives great. My complaint is that it come nowhere close to the mileage they claim in the city, at lea...Read Full Review
Glad I selected the Sport model - I purchased my first Honda after trading in my 2003 Mazda6s and so far I have been pleased. It lacks the performance of my old V6 mazda, but still per...Read Full Review


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