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User Tip: If you're unsure of your vehicle type, you may skip the machine type selection box.
Select type, make, model and year above
"Customer service is priority #1 at Rocky Mountain ATV/MC. We value our customers and strive to be the best shopping experience- when you buy from us, you are buying lifetime service."
-Dan Thomas, CEO and Founder
We take pride in offering no hassle returns. In the event of a return, please call, email or chat with us to receive a solution to the problem. For apparel that doesn't fit quite right, Click here to see our Fit Guaranteed Program.
We will stand behind all products we sell with regards to manufacturing defects in workmanship and material. Most products are limited to the manufacturer's warranty. However, we will do everything in our power to take care of the problem.
Live chat: Click here
(Leave email if after hours)
Call us: 1 800 336-5437
7am-7pm Mon-Fri 8am-4pm Sat (Mountain Standard Time)
Each review submitted enters you into a $100 gift card monthly drawing, and a $500 gift card quarterly drawing!
Comments On Jul 17, 2014:These rims add another level of style to the machine. They look good on any machine that ive seen. Great product and would recommend for everybody looking to add some style to there machine.
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Comments On Dec 01, 2013:I use these as a sand tire so I haven't tested there strength but if you are looking for a great looking wheel these will exceed your expectations!
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Comments On Nov 20, 2013:This makes my bike look a million bucks. The ofset also makes the rear end wider and more stable when riding. Ive had them a while and the paint hasn't faded or blemished, still looks awesome. Glad I bouhgt these, both looks good and functional.
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Comments On Jul 16, 2013:These look beautiful on my Raptor. Havent riden on them much yet but they seem sturdy enough for the way I ride.
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Comments On May 11, 2013:They look great and are holding up well
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Comments On Mar 17, 2013:Can't wait to post pictures, show off my 2002 banshee with this awesome wheel package. Awesome doing buisness with Rocky Mountain again! Shipping was awesome........
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Comments On Feb 25, 2013:Make the stance ride in the rear with the offset I got. I use them for my paddles no problems with jumping ect.
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Comments On Feb 14, 2013:made my 2000 warrior look like a totally different bike looks way more sporty i like them now all i need are some tires to go with them also make sure you get the lugnuts they recomend for them
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Comments On Jan 16, 2013:Looks amazing and not that heavy!
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Comments On Aug 29, 2012:this is a very nice wheel. 660 raptor looks great with these .
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"Red" @ Cotuit Center for the Arts
When: Sat Apr 13th
8:00 pm - 10:00 pm
Where: Cotuit Center for the Arts | 4404 Falmouth Road | Cotuit
"Red," John Logan's award-winning play about the life and art of Mark Rothko, will run at Cotuit Center for the Arts April 11 through April 28. The production will be directed by Mary Arnault.
Performances are Thursday, Friday, and Saturday at 8 PM and Sunday at 2 PM.
"Red," which won the 2010 Tony Award and the Drama Desk Award for best play, is a riveting portrayal of abstract expressionist painter Mark Rothko (1903-1970), one of the foremost artists of the 20th century. Paint and canvas collide as the play explores the purpose of art and the relationship between the artist and his work.
Tickets are $22, $19 for seniors, $17 for members, and $15 for students.
Cotuit Center for the Arts is at 4404 Route 28 in Cotuit. For more information, visit artsonthecape.org or call 508-428-0669.
See more events with tags: cotuit center for the arts theater paint drama red

subset: commoncrawl


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This item is temporarily out of stock. However, we can notify you as soon as this product becomes available.
Thank you
We have received your request and you will be notified as soon as this product becomes available.
Description: Crop In Style NaNavigator is the ideal mid-size tote. This wonderful tote comes with adjustable or removable interior to make packing more convenient and also includes loops and compartments for all your accessories. The tote is made with a rugged hard-case construction and includes a sturdy lid that allows for stacking whenever needed. Interior holds your Paper and Sticker Binders and albums with plenty of room to spare. Also has telescoping pull-up handle and in-line skate wheels to make traveling easier. 20"x 19"x 12" Black
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Rebecca's Q & A
Who's your favorite sports team, and why?
Iowa Hawkeyes- Not only am I from Iowa City, I was a college cheerleader for the Hawks! Born and breed baby!
What's your favorite movie quote?
"You've had two pairs of gloves on this entire time?? Uh, yeah, its the Rocky's??" Dumb and Dumber
What's your favorite video game, and could you kick our butts at it?
I do not play video games!
Piercings/Tattoos (How many? Where?)
Just my ears!
What's the most embarrassing song on your iPod?
Everybody Makes Mistakes - Miley Cyrus
What's your best party trick?
In college I used to do flips in the bar. 1 flip= round for my friends
What's the most memorable pick-up line you've ever heard?
"Can I marry you?"
What's the worst job you've ever had?
I grew up on a farm, definitely shoveling out the horse shed.
What's the most dangerous thing you've ever done?
I was gymnast and I think everything in gymnastics is pretty dangerous!
It's 4AM after a crazy night out – what are we eating?
Papa Johns
What's the naughtiest thing you've ever done in public?
I'm a good girl.
What do you feel sexiest wearing?
Jersey and underwear/ bra and underwear/ swimsuit
Tell us a joke.
I'm terrible at telling jokes... I take too long and by that time they're not funny anymore...


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Choose one of the offers below. Offers are usually short surveys or signup forms.
Fill out the offer with valid information and a working email address. If your information is detected as fake when it is reviewed, you / your IP (188.8.131.52) will be banned from our service.
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text:
Three surgeries later, T.J. still going strong
It's the summer before his first grade year and Tyrone Smith, Jr is not letting a little thing like a hole in his heart slow him down.
He was born Feb. 9, 2006 with a hole in his heart. As a result, one of his heart valves will not remain open. The summer of 2009 doctors discovered that Tyrone was experiencing just 20 percent blood flow to one lung and 80 percent to the other.
Tyrone Smith Sr, said his son – nicknamed T.J. remains full of energy in spite of two heart surgeries and one lung surgery the little boy already has behind him.


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28 U.S. Code § 1406 - Cure or waiver of defects
(a) The district court of a district in which is filed a case laying venue in the wrong division or district shall dismiss, or if it be in the interest of justice, transfer such case to any district or division in which it could have been brought.
(b) Nothing in this chapter shall impair the jurisdiction of a district court of any matter involving a party who does not interpose timely and sufficient objection to the venue.
Source(June 25, 1948, ch. 646, 62 Stat. 937; May 24, 1949, ch. 139, § 81,63 Stat. 101; Pub. L. 86–770, § 1,Sept. 13, 1960, 74 Stat. 912; Pub. L. 87–845, § 10, Oct. 18, 1962, 76A Stat. 699; Pub. L. 97–164, title I, § 132,Apr. 2, 1982, 96 Stat. 39; Pub. L. 104–317, title VI, § 610(b),Oct. 19, 1996, 110 Stat. 3860.)
Historical and Revision Notes
1948 Act
Subsection (a) provides statutory sanction for transfer instead of dismissal, where venue is improperly laid.
Subsection (b) is declaratory of existing law. (See Panama R.R. Co. v. Johnson, 1924, 44 S.Ct. 391, 264 U.S. 375, 68 L.Ed. 748.) It makes clear the intent of Congress that venue provisions are not jurisdictional but may be waived.1949 Act
This section removes an ambiguity in section 1406 (a) of title 28, U.S.C., by substituting "may" for "shall", thus making it clear that the court may decline to transfer a case brought in the wrong district under circumstances where it would not be in the interest of justice to make such transfer. [The amendment to section 1406 (a) of this title described in this note was altered in the bill as enacted. See Cong. Rec., vol. 95, pt. 5, pp. 5826, 5827, 6283, 6284.]
1996—Subsec. (c). Pub. L. 104–317amended subsec. (c) generally. Prior to amendment, subsec. (c) read as follows: "As used in this section, 'district court' includes the United States District Court for the District of the Canal Zone; and 'district' includes the territorial jurisdiction of that court."
1982—Subsecs. (c), (d). Pub. L. 97–164redesignated subsec. (d) as (c). Former subsec. (c), which provided that if a case within the exclusive jurisdiction of the Court of Claims were filed in a district court, the district court, if it were in the interest of justice, was required to transfer the case to the Court of Claims where the case would proceed as if it had been filed in the Court of Claims on the date that it was filed in the district court, was struck out.
1962—Subsec. (d). Pub. L. 87–845added subsec. (d).
1960—Subsec. (c). Pub. L. 86–770added subsec. (c).
1949—Subsec. (a). Act May 24, 1949, inserted "dismiss, or if it be in the interest of justice".
Effective Date of 1996 Amendment
Amendment by Pub. L. 104–317applicable to cases pending on Oct. 19, 1996, and to cases commenced on or after such date, see section 610(c) ofPub. L. 104–317, set out as a note under section 1404 of this title.
Effective Date of 1982 Amendment
Amendment by Pub. L. 97–164effective Oct. 1, 1982, see section 402 ofPub. L. 97–164, set out as a note under section 171 of this title.
Effective Date of 1962 Amendment
Amendment by Pub. L. 87–845effective Jan. 2, 1962, see section 25 ofPub. L. 87–845, set out as a note under section 414 of this title.
Effective Date of 1960 Amendment
Pub. L. 86–770, § 4,Sept. 13, 1960, 74 Stat. 913, provided in part that: "The amendments made by sections 1 and 2 of this Act [adding subsec. (c) of this section and section 1506 of this title] shall apply to any case or proceeding pending on, or brought after, the date of enactment of this Act [Sept. 13, 1960] in the district courts or the Court of Claims."
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
An empty table indicates that we see no relevant changes listed in the classification tables. If you suspect that our system may be missing something, please double-check with the Office of the Law Revision Counsel.
|Description of Change
|Session Year
|Public Law
|Statutes at Large
LII has no control over and does not endorse any external Internet site that contains links to or references LII.


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Windows 7 Product Guide.pdf
Windows 7 Product Guide XPS.xps
Windows 7, Windows Vista, Windows XP
The Microsoft DirectX® End-User Runtime provides updates to 9.0c and previous versions of DirectX — the core Windows® technology that drives high-speed multimedia and games on the PC.
This tool checks your computer for infection by specific, prevalent malicious software (including Blaster, Sasser, and Mydoom) and helps to remove the infection if it is found. Microsoft will release an updated version of this tool on the second Tuesday of each month.
Download and run the Windows 7 Upgrade Advisor to see if your PC is ready for Windows 7. It scans your hardware, devices, and installed programs for known compatibility issues, gives you guidance on how to resolve potential issues found, and recommends what to do before you upgrade.
This installation package is intended for IT professionals and developers downloading and installing on multiple computers on a network. If you're updating just one computer, please visit Windows Update at http://update.microsoft.com .
Windows 7 and Windows Server 2008 R2 SP1 helps keep your PCs and servers on the latest support level.
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Browse our collection of laptops, tablets, and convertibles perfect for the new Windows.
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Download Summary:
A download manager is recommended for downloading multiple files.
Manage all your internet downloads with this easy-to-use manager. It features a simple interface with many customizable options:
Would you like to install the Microsoft Download Manager?
Generally, a download manager enables downloading of large files or multiples files in one session. Many web browsers, such as Internet Explorer 9, include a download manager. Stand-alone download managers also are available, including the Microsoft Download Manager.
if you do not have a download manager installed, and still want to download the file(s) you've chosen, please note:
The Microsoft Download Manager solves these potential problems. It gives you the ability to download multiple files at one time and download large files quickly and reliably. It also allows you to suspend active downloads and resume downloads that have failed.
Microsoft Download Manager is free and available for download now.


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Tesco Partners directory
- Tesco Partners directory
- Frequently asked questions
- Tesco Partners Guarantee
Avalaya is a fashion and costume jewellery specialist offering thousands of brooches, earrings, bracelets, armlets, necklaces, bangles, pendants, bangles, hair accessories and other related products.
Bigjigs Toys delivers quality, safe and affordable toys, which are responsibly sourced and complement childhood through fun, exploration and learning.
Brantano Footwear stock a huge range of big brand shoes for the whole family, including Clarks, Nike, Hush Puppies and Skechers.
Clearwater Hampers
Clearwater has one of the largest range of food and wine gifts for delivery anywhere in the UK. Originally founded to supply Christmas hampers, we now sell gifts for all seasons and occasions and provide a "create your own" gift hamper feature
Cleverboxes Limited have been supplying a wide range of quality products for over 10 years. Our philosophy is simple - we offer old fashioned customer service utilising new technology to secure great products at great prices.
Whether you are a professional chef, or someone who just loves to bake, Colanders aim is to provide you with all that you could possibly need. From mixers to plates, preserving jars and much, much, more, we hope you will find everything you need to make your time in the kitchen a success.
Cooking Marvellous
Cooking Marvellous is an online Specialist Cookshop. We carry an extensive range of quality specialist cookware to suit all foodies, from enthusiastic home cooks right through to professional chefs.
Buy plants from our online garden nursery. We offer a wide range of plants from perennials, shrubs, climbers, trees, grasses, bamboos, bulbs, seeds, roses and vegetables.
Divine Audio
Divine Audio was set up in 2004 and has always specialised in two channel and cinema systems at affordable prices.
Direct Golf UK
Direct Golf UK - Europe's No.1 award-winning specialist golf retailer.
Early Learning Centre
Early Learning Centre, helps mums and children grow into happy, self-confident people. They create fantastic toys, toys that help develop vital skills, toys that help children get off to the best possible start, and toys that are tremendous fun. All our toys are designed to help children explore the boundaries of their imaginations and creativity, to make learning fun and help children be all they can be.
Euro Car Parts
Euro Car Parts is no longer trading at Tesco direct
Find me a gift
Find Me A Gift is a company selling over 8000 gifts. Set up in 2000 from a spare bedroom, our MD wanted to create a site where people like him could go to find a plethora of gift ideas. As a young man, he struggled to find the perfect gift for friends and family, and he believed there were many people in the same boat.
Fred Aldous
Our story began in Manchester in 1886, with a man called Fred. Fred had two things: a bright idea, and a cracking beard. He'd been working in a cotton mill, like many people in the city at the time, when he noticed that the cotton was being trundled around in baskets. This gave him an idea for a business. Fred wanted to start importing the cane for the baskets from abroad. And so we, Fred Aldous Ltd, were born. Today, we stock over 25,000 arts, craft and hobby supplies.
Fun Collectables
Established in 1999 we are a UK based Toy Retailer born from a collectors passion of TY Beanie Babies. We now supply a wide range of toys and games, all offered with a high level of customer service. Our products range from collectable trading cards to the latest action figures.
GAK is the UK's largest independent musical instrument retailer, trading for over 20 Years. We pride ourselves on offering our customers The Best Price & The Best Service on 1000's of musical instruments, recording studio and live sound equipment
Garden Centre Direct
Garden Centre Direct features the very best brands, convenient delivery and great prices. With one of the largest selections of garden buildings delivered directly to you, Garden Centre Direct makes things easy for you.
Harts of Stur
Hart Of Stur - Award winning specialist in Cookware, Kitchenware & Kitchen Electricals
Heat and Plumb
Heat and Plumb is no longer trading on Tesco Direct
Heritage Gifts
We supply a wide range of products from kitchenware and cleaning through to gardening and DIY. With many top brands including Addis, Brabantia, Croydex, Vileda and many more top household suppliers.
House of Fraser
With over 160 years experience of being on trend every season, House of Fraser is the landmark British department store bringing the world's premium brands together to create a sensational & inspirational shopping experience for our customers
Howleys Toys
Howleys Toy Shop is always up to date with the latest releases and crazes. Their growing online and high street stores have become a goldmine for all the latest toys, collectables, models and outdoor entertainment.
Established in 1921, Hughes is one of the UK's largest electrical retailers. Inspiring customer loyalty through quality service, we provide the latest technology and household appliances, along with a fully tracked delivery service.
Sellers of: Musical Instruments DJ Equipment, Public Address, Studio Equipment.
Jewelco London. The place for quality gold, silver and diamond set jewellery and wedding rings at competitive prices, delivered fast.
Jokers' Masquerade
Jokers' Masquerade has the largest online collection of fancy dress costumes & Halloween costumes in the UK. We stock the latest and greatest costumes and accessories from the world's best suppliers.
Ladders Online
Ladders-Online launched in 1999 and offers the widest range of ladders, loft ladders and step ladders in one place. One of the few early pioneers to sell quality certified ladders direct, we've built up our range with additional sizes, internationally recognised brands and a selection of specialist ladders to suit almost
Lakeland Furniture
Lakeland Furniture specialises in reproductions of modern design classics as well as carrying an extensive range of the UK's best value bar stools, dining chairs, office chairs, tables and furnishing accessories.
Locks Online
LocksOnline is no longer trading on Tesco Direct
Mamas and Papas
Mamas & Papas. Designed by parents, for parents. Being Mums and Dads ourselves informs the design of every pushchair, sleepsuit and highchair. We're here for you at every stage of parenting. Since 1981.
Maplin Electronics is the UK's biggest and best specialist retailer of consumer electronics, offering over 15,000 electronic products, gadgets and components online and across a national network of 205 stores.
We're sorry but this Tesco Partner is not currently selling on Tesco direct, although they are available to support you with any post-order queries you may have
With over 50 years experience Mothercare offers a wide range of maternity and children's clothing, furniture and home furnishings, bedding, feeding and bathing equipment, travel equipment and toys.
Mountain Warehouse
Mountain Warehouse has been developing the very best outdoor gear for all the family since 1997. They design their own top quality products and have them made to their exact standards, this means you get the exact same quality, but at significantly lower prices than you'll find at other shops.
Mr Pets
Mr Pets is dedicated to delivering you genuine pet products cheaply and quickly. We offer the reassurance that our customer service team is backed up by the expertise of fully qualified staff members and fellow pet lovers.
Normans are a leading UK musical instrument specialist. Offering great service, friendly advice and unbeatable prices.
Olive and Finch
Must have jewellery, gifts, cufflinks & accessories for men, women & children including the entire Diamond Kids range of children's jewellery.
Parkers of Bolton
Need something to ride, drive, sail or fly? Parkers of Bolton is a one stop shop for your favourite outdoor pursuits.
The Plasma Centre are the UK's leading specialists in TV Stands, Cabinets and Wall Brackets. We carry huge stocks to enable quick and easy delivery direct to your home or to your nearest Tesco store.
Powerhouse Fitness
Powerhouse Fitness is one of the largest internet retailers of Fitness Equipment, Gym Equipment and Sports Nutrition products in the UK. With over 2000 high quality products, you're sure to find the item that meets your fitness needs at the right price.
Through dedication to outstanding customer service and offering highly competitive prices on our great product range, PreciousLittleOne has grown to be one of the largest independent nursery retailers in the country.
Founded in 2000, Prezzybox is the complete online gift solution. We have gone from strength to strength since then by maintaining a simple ethos - selling a great range of unique and exciting gifts, with a fun and friendly approach, whilst maintaining a strong customer-focused service.
Pure Fitness & Sports
Established in 1995, we offer the finest quality fitness products at competitive prices, backed by the best service anywhere. Like you, we have a real passion for sports & fitness and our goal is to be the No.1 Fitness & Sports Retailer by providing our customers with the best shopping experience.
QP Jewellers
From elegant diamond & amethyst earrings to stunning ruby necklaces, the QP ranges have something to offer for every occasion and special moment life may bring.
Safetots was founded in 2003 to provide a shopping destination for the very best brands in baby and child safety products. We offer the widest choice of child safety products to parents and carer's to enable them to provide a safer environment for their children to grow up in.
Superfi is one of the UK's largest hi-fi and home cinema specialists. We're part of a company that's been trading since 1929, and in this day and age you don't last that long unless you know a thing or two about your products!
The Children's Furniture Company
We design and manufacture stylish and high quality children's bedroom furniture and beds.
The Entertainer
The Entertainer is one of the UK's largest toy retailers with 80 stores nationwide. We were named Online Toy Retailer of the Year in 2012 and 2013.
The Jewel Hut
We're sorry but this Tesco Partner is not currently selling on Tesco direct, although they are available to support you with any post-order queries you may have.
If you're looking for nutritional products, vitamins and minerals, herbal and holistic remedies, sports supplements or beauty products you are in the right place.
The Watch Hut
We're sorry but this Tesco Partner is not currently selling on Tesco direct, although they are available to support you with any post-order queries you may have
Buy mail-order young plants, fruit and vegetables from Thompson & Morgan - renowned for quality, service, innovation, and award-winning breeding.
Totallygadgets offers the very best brands for digital accessories at competitive prices in the UK. As a family run business with over 18 years of experience we pride ourselves on our top quality products and first class service.
UKSoccershop is a leading supplier of football shirts, football clothing and football merchandise. Since 2004, UK Soccer Shop have offered a wide range of club and international football shirts from all the major leagues including Premier League, La Liga, Serie A and Bundesliga.
Urban 33multi-website online retailer, whose passion for providing a trusted and personal online experience has led to rapid growth both in the UK and internationally since its birth in 2007
Watch Warehouse
WatchWarehouse officially launched on-line in 2007, has a long history dating back to 1939 and is still 4th generation family owned. It has fast become the UK's most popular and trusted multi-channel retailer of branded watches.
Watson's on the web
30 years as designers and importers of high quality and innovative Home and Leisure products for high street retail. Primary product categories: Furniture, Storage, bathroom & kitchen accessories, home wares and gifts.
We offer 5000 brands of home furnishings in every style, period, price point, form, function, and finish. From antiquity to modernism, Bali to Berlin, price shopper to prince. We carry it all
Websters Pen Shop
The UK's premier independent retailer of writing instruments, boasting ranges from around the world including Cross, Parker, Stabilo, Visconti and many more.
Willis Judd
We're sorry but this Tesco Partner is not currently selling on Tesco direct, although they are available to support with any post-order queries you may have.
Y Frame Discounts
Y Frame Discounts Ltd is an independent online business providing a range of over 30,000 cycles and cycling accessories.


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Steph in MGM Grand's Crazy Horse Paris
A great time on Saturday May 21st, as MGM Grand's Crazy Horse Paris celebrated their 10th Anniversary and invited Steph to guest star. Steph did great and a fun time was had by all!
Steph and Friends
Photo 3 of 8
Steph and Winner
Steph and Chris
Steph and Friends
Steph Hanging On the Lips
Steph and Jennifer
Steph After Show
Steph Gettin Ready To Hit Stage
Steph Rehearsel


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State of Conservation (SOC)
Old City of Dubrovnik
Old City of Dubrovnik
Date of Inscription: 1979
Category: Cultural
Criteria: (i)(iii)(iv)
Danger List: Yes
- Management systems/ management plan
Inscription on the Danger List
Year: 1991 -1998
Threats to the Site:
Threats to the Site:
Noting the state of exceptional emergency caused by the armed conflict, the Committee decided to inscribe the Old City of Dubrovnik on the List of World Heritage in Danger.
* :
The threats indicated are listed in alphabetical order; their order does not constitute a classification according to the importance of their impact on the property.
Furthermore, they are presented irrespective of the type of threat faced by the property, i.e. with specific and proven imminent danger ("ascertained danger") or with threats which could have deleterious effects on the property's Outstanding Universal Value ("potential danger").
** : All mission reports are not always available electronically.


text:
Thousands of area residents can now look forward to a new source of water, which will also take pressure off a lake that's drying up.
Five area cities and several other communities depend on Lake Greenbelt which continues in a state of emergency.
Greenbelt Water Authority Director Gary Campbell says they've recently finished drilling five new wells and building pipelines to provide more water. The last step before they can start pumping is completing a 14 inch pipeline that will transport water from the wells in Clarendon to the treatment plant.
Campbell says, "The people have really tried to cut back on water usage, and they've done a good job. But people are concerned. I mean, everybody knows that lake is in bad shape." 25,000 people are depending on Lake Greenbelt, but in about three weeks the wells are expected to supply a third of their water by providing about a million gallons a day.
However, the director says on average they need about three and a half million a day. So they're currently working on drilling another four wells and continuing to look at other options to increase supply.
Jessica Abuchaibe, NewsChannel 10.


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Cox Business is the smart choice for hotels who want greater flexibility from their free-to-guest (FTG) television offering, with more dedicated hospitality experience, expansive HD channel lineup and a large room base. Your guests receive an array of viewing options that will heighten their overall hotel experience.
More flexibility and scalability. Whether you're a small property or a big resort, we provide a customized package of TVservices designed with future growth in mind. You also get customizable, branded in-room materials, so you can delight and retain your guests at every level.
First-rate benefits. With superior picture, sound quality and reliability, your guests receive an array of viewing options that will heighten their overall hotel experience.
Customized, flexible options. Whether it's our encrypted HD programming with no equipment or our new in-room (easily hidden) HD receiver solution, Cox Hospitality TV provides options that can work with or without existing Pro:Idiom televisions.
Video on demand (VOD). Our Pro:Idiom encrypted high definition services can be integrated into many of the more commonly used Video On Demand (VOD) entertainment systems to deliver a seamless experience for hotel guests.
The HD channels you need and more HD your guests want. We serve up 10 select companion HD channels from our Cox Business TV Bulk using solutions that won't break your budget.
Offices and Common areas. Our solutions include special options for private offices, lobbies and common areas, and even the restaurants and bars inside your property


text:
Some information is missing or invalid below.
Learn more.
These dazzling Indianapolis Colts earrings from LogoArt are perfect for the die-hard fan.
Earring Details:
- Length: 1.06-in.
- Backings: post
- Metal: silver tone
- Features: dangling logo charms with black enamel
- Model no. COL067ER-CR
Crystal Details:
- Cut: round
- Color: blue
- Setting: bezel
Promotional offers available online at Kohls.com may vary from those offered in Kohl's stores.
Sponsored Links
The links below are ads provided by the Google AdWords™ program. Outside companies pay to advertise via these links when specific phrases and words are searched. These ads are provided by Google and are labeled as sponsored links. Clicking on these links will open a new tab displaying that respective company's own website. The website you link to is not affiliated with or sponsored by Kohls.com


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Madeline's Q & A
Favorite Sport/Team
Favorite Movie/Actor
Leonardo Dicaprio
Go-to karaoke song
I will Survive
My first job
Jamba Juice
Piercings/Tattoos (How many? Where?)
Mac or PC?
Nintendo, Xbox 360, PS3, or don't game?
Nintendo - I
What fun fact, talent or superpower of yours should guys know about?
I'm athletic, i'll kick your booty
What's the most memorable pick up line you've ever heard?
I want to be on you
What's the craziest thing you've ever done?
Broke into a club and partied
What's the most unusual place you've ever hooked up? How'd it go?
Rooftop of my apt complex, mid-day . . . HOT
What's in your purse or pocket right now?
Cell, lip gloss, ID, ca$h
What do you feel most comfortable wearing?
Daisy dukes and a tank top
Would you rather have boring sex all the time or an amazing romp once a year?
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
Jersey Shore Cast


text:
By Amy Lange
OAK PARK, Mich. (WJBK)
A special thank you going out for one of the heroes of last week's deadly pileup on I-75. The Windsor father who lost two of his children in the accident says he is forever indebted to a Michigan state trooper because that first responder helped save one of his daughters.
Trooper Seth Swanson was first on scene at the deadly pile up on I-75 at Springwells. In that car he discovered two children he couldn't save, but a third had a chance.
"She wasn't breathing, she was unconscious but she had a very faint pulse" Swanson said. He cleared her airway started rescue breaths. A first, a second and then a third. Finally she took a deep breath and she was awake, he said.
Awake and hurt, her seven-year-old brother, Aidan Hicks, and nine-year-old sister, Gabrielle Greenwood, beside her in the car, both gone. But 10-year-old Hannah had made it. Their parents were also hospitalized and on Tuesday, Trooper Seth Swanson paid them all a visit, meeting Hannah again.
"From what I understand she's her old self, which is great. She didn't recognize me which is okay. But she's okay," Swanson said.
And her family will never forget him. Glen Greenwood hadn't realized Trooper Swanson saved his daughter's life. "He shook my hand and he actually he gave me a hug so he was very, very happy" Swanson said.
And so grateful he posted a message to Facebook after he and Hannah were released from the hospital. It read, "I would like for all to know Officer Seth Swanson of the Michigan State Police. That young man is my hero and saved my little girl's life. I am in eternal debt to that officer. Thank you!"
Swanson said on Wednesday, "it's nice to hear - I'm just glad we're able to help out."
Trooper Swanson has been with the Michigan State Police for four years. He says he's never seen a crash this bad and it's the first time he's had to use his CPR training on a child in a situation like this.
He's quick to thank all of the other first responders who made a such difference on that terrible day. Like Glen Greenwood said, they're all heroes.
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The Knights claimed the title Saturday night, Dec. 29, at Tracy High with an 82-34 win over the Patterson Tigers.
Saturday night's game capped four days of basketball for 16 girls teams playing at Tracy and West high schools.
Also Saturday, the Gregori High girls basketball team took third place with a 45-41 win over Tracy.
Consolation trophies went to Foothill High of Palo Cedro, which beat Manteca 50-33 on Saturday at West High, and Napa High, which beat Mission San Jose of Fremont 37-31 at Tracy High.
Brookside Christian 82, Patterson 34
The Knights allowed Patterson just one field goal for the entire first quarter to take a 31-2 lead.
The Tigers matched Brookside's pace in the second quarter as they fought for rebounds and passed well enough to break through Brookside's press.
But the Knights (11-2) continued their aggressive game in the second half to keep Patterson (11-2) in check.
Brookside junior Tiara Tucker led all scorers with 28 points and hit six of the Knights' 15 3-point shots. Brookside sophomore Ariana Vaughn scored 17 points, including four 3-pointers.
Patterson junior center Mele Topouata led her team's offense with 14 points. She and junior guard Jovanna Arrington were named to the all-tournament team.
Brookside sophomore Ra'kyra Gabriel was named the tournament's most valuable player, and freshman Mi'cole Cayton was an all-tournament selection.
Gregori 45, Tracy 41
The Bulldogs and Jaguars were tied at 15-15 three minutes into the second quarter, but Gregori senior guard Marissa McDuffy gave her team a spark by fighting for turnovers and rebounds going into the half.
Tracy (8-7) got close again at the start of the third with shots from senior center Shelby Perry and senior guard Taylor Juarez, and Karsi Fyfe hit a 3-point shot at the end of the third to cut Gregori's lead to 36-35.
But Gregori (12-1) extended its lead early in the fourth and answered each of Tracy's shots to hang on for the win.
Tracy coach Derek Solano said his team put up an admirable effort against a strong opponent.
"I just told the girls that we had a similar situation last year when we played really well and lost the game," he said. "It was one of our more well-played games, so we hope that's something we carry forward to West (at home Thursday, Jan. 3) and then into league."
Leading Tracy's offense were senior guards Tammy Serrato and Emily Anchartechahar with nine each. Perry scored eight, and Fyfe, Tracy's all-tournament selection, contributed seven.
Gregori's McDuffy led all scorers with 27 points, including 11 of 15 free throws, and was her team's all-tournament pick.
West 45, Tokay 26
The Wolf Pack got off to a strong start Saturday against Tokay and kept up the pace through the second and third quarter to build 41-20 lead going into the fourth.
West (9-7) stayed in control through the second half and limited Tokay (1-12) with an effective full-court press and strong rebounding from junior Nini Woodward and freshman Gabrielle Keane.
West sophomore Kate Bell said that even though her team went 1-3 for the week, the games were close and the team can see where it needs to improve.
"I definitely saw us improving, and I'm definitely looking forward to league starting up in a few weeks," she said.
Leading the offense for West on Saturday were sophomore Sandy Barbosa and senior Emma Bell with 11 points each, and Woodward and Kate Bell had eight points each.
Other Saturday scores
Lathrop 53, Modesto 33
East Union 43, Turlock 37
El Camino 60, Mills 54
• Contact Bob Brownne at 830-4227 or firstname.lastname@example.com.


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Publication: theday.com
After a 69 win season and shedding 250 million dollars in salaries I, like the rest of you, are interested to see what the Boston Red Sox are planning to do this offseason.
Signing David Ortiz to the 2 year, 26 million dollar I'm good with. Hopefully after the 2 years the Red Sox will have paid Big Papi 30 million dollars due to him reaching the incentives placed in the new contract.
Besides that, the names I'm hearing are just not that exciting.
Mike Napoli? Adam LaRoche? Hiroki Kuroda? I'd take a look potentially for a one year deal which none of them want.
I also don't get this fascination in the media with Mike Napoli. I know that his numbers are very good at Fenway…but that's against Red Sox pitching which, over the past 3 years, hasn't been that great. For me, with the resources available, he would not be the answer for the everyday first baseman. There has to be a better option.
Speaking of fascination, can we stop with Justin Masterson and Shin Shoo Choo for Jacoby Ellsbury. I'm not even going to go into this because this couldn't make less sense.
The signing of David Ross as a back-up catcher makes sense if they are going to try and package Salty or Lavarnway in a trade but for me 2 years, 6.2 million dollars seems a little much for a player that might play 60 games.
All eyes are on Ben Cherington and the Red Sox front office. Hopefully these initial names are just that and there's some more creativity being discussed behind closed doors.
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NIH Research Festival Features Chromosome Biology Dr. Francis Collins kicked off the annual NIH Research Festival last month with a story about a man who loses his keys on the way into a bar. The man is searching under the only lit lamppost outside the bar when his friends find him and ask why he has limited his search to under the lamppost. The man replies, "Well, that's the only place I could see."
Dr. Collins, who directs the National Human Genome Research Institute, told the story to illustrate what life was like for gene hunters before the human genome sequence became available a few years ago. Researchers looked for gene variants involved in common diseases in only a fraction of the genome - because that's all they could see.
Advancing Cancer Control Science to Improve Public Health
This issue of the NCI Cancer Bulletin highlights and celebrates the research, actions, and partnerships of NCI's Division of Cancer Control and Population Sciences (DCCPS), which this month is celebrating the 10th anniversary of its founding.
Since its creation in 1997, DCCPS has spearheaded NCI's efforts to understand the causes and distribution of cancer in different populations, supported the development and delivery of effective behavioral interventions, and monitored and explained cancer trends in all segments of the population.
NIH Research Festival Features Chromosome Biology
Dr. Francis Collins kicked off the annual NIH Research Festival last month with a story about a man who loses his keys on the way into a bar. The man is searching under the only lit lamppost outside the bar when his friends find him and ask why he has limited his search to under the lamppost. The man replies, "Well, that's the only place I could see."
Dr. Collins, who directs the National Human Genome Research Institute, told the story to illustrate what life was like for gene hunters before the human genome sequence became available a few years ago. Researchers looked for gene variants involved in common diseases in only a fraction of the genome - because that's all they could see.
The human genome has now been "lit up" and researchers can search for genetic factors in a long list of human diseases without having to have a good guess or hunch about where to look, noted Dr. Collins.
"There are consequences of this revolution for your own research," he told a capacity crowd during the festival's opening plenary session on September 25 in Masur Auditorium on the NIH campus. Many in the audience would present their research in dozens of lectures and hundreds of poster presentations over the next 4 days.
The agenda covered the range of biomedical research and diseases being studied at the 27 NIH institutes and centers. Many talks and posters discussed the mechanics of genomes and chromosomes in health and disease. RNA was a popular topic, and so was cancer.
The plenary session, "Chromosomes in Modern Biology and Medicine," featured two speakers from NCI's Center for Cancer Research (CCR). Dr. Shiv Grewal discussed heterochromatin, a chromosome structure that packages DNA, and its role in regulating a variety of activities in the genome. Dr. Thomas Ried talked about cancer as a disease of the chromosomes.
A videocast of "Chromosomes in Modern Biology and Medicine" is available.
One of the lighter moments of the meeting came when Dr. Ried described an embarrassing period in the history of chromosome research. In the 1950s, after researchers could finally see that humans have 46 chromosomes rather than 48, as was the accepted belief, it took another 4 years before the truth was accepted.
The reason, Dr. Ried told his audience of mostly young researchers, was that 48 chromosomes had been established as dogma by individuals who were now department chairs and university presidents. The young cytogeneticists were reluctant to challenge the dogma, even though they had counted the 46 chromosomes for themselves.
"There's a lesson to be learned here," Dr. Ried added. "You should believe what you see and challenge your mentor."
Later that day, in a symposium on genetic variation and common diseases, Dr. Stephen Chanock of NCI's Division of Cancer Epidemiology and Genetics (DCEG) related some lessons from the Cancer Genetic Markers of Susceptibility (CGEMS) program.
"Replication, replication, replication," Dr. Chanock said, referring to the need to validate initial results from genome-wide association studies and avoid false positives. He also stressed that very large studies will be needed to detect variants involved in diseases such as breast and prostate cancers.
In the world of doing genome-wide association studies, bigger is always preferred in order to maximize the power to detect variants, according to Dr. Chanock, who directs the NCI Core Genotyping Facility and heads the newly formed Laboratory of Translational Genomics in DCEG.
In conjunction with the research festival, the NIH Office of Intramural Training and Education and the Office of Research on Women's Health sponsored an annual job fair for NIH postdoctoral, research, and clinical fellows. A list of exhibitors and more information, including a virtual job fair, is available here.
On the first day, Dr. Michael Gottesman, deputy director for intramural research at NIH, reviewed the history of the NIH festival, which was celebrating its 20th anniversary (the festival began in 1986, but it was not held the following year).
The festival was in part the vision of Dr. Abner L. Notkins of the National Institute of Dental and Craniofacial Research. Dr. Notkins and others had recognized that scientists from across the NIH would benefit from coming together and sharing ideas. The organizers also wanted the festival to be a place where young investigators and mid-career scientists could present research.
NIH has changed considerably since 1986, but it remains "the best place to do long-term, high-risk biomedical research in the laboratory or the clinic," Dr. Gottesman said. "We still need to do more to enhance research across the institutes," he added.
—Edward R. Winstead
Advancing Cancer Control Science to Improve Public Health
This issue of the NCI Cancer Bulletin highlights and celebrates the research, actions, and partnerships of NCI's Division of Cancer Control and Population Sciences (DCCPS), which this month is celebrating the 10th anniversary of its founding.
Since its creation in 1997, DCCPS has spearheaded NCI's efforts to understand the causes and distribution of cancer in different populations, supported the development and delivery of effective behavioral interventions, and monitored and explained cancer trends in all segments of the population.
Created as a result of a recommendation by a special Cancer Control Program Review Group, DCCPS is truly unique. Thanks to the breadth of the research it conducts and supports, and the transdisciplinary nature of that work - which encompasses genetic, epidemiological, behavioral, social, applied, and surveillance cancer research - over the past decade it has generated important new insights and helped to ensure that the products of cancer control research are effectively applied in communities across the country.
In its 10-year history, DCCPS has funded a large and expanding portfolio of grants and contracts. The current portfolio includes more than 900 grants valued at almost $400 million. This issue of the NCI Cancer Bulletin includes articles on just a handful of DCCPS programs, providing a glimpse of the diverse, integral research the division conducts and supports.
Among the most well-known of DCCPS' programs is the Surveillance, Epidemiology, and End Results (SEER) program, the most comprehensive, population-based cancer registry in the world, covering 26 percent of the U.S. population. SEER data provide the foundation for numerous important studies each year, studies that are helping to guide diagnosis and treatment of cancer. Last fall, for example, University of Michigan researchers, using SEER data, closely assessed renal cell carcinoma rates and treatment patterns and found a rise in mortality rates despite increased detection and treatment of smaller tumors, raising the question of effectiveness of the current treatment paradigm.
The DCCPS-supported Cancer Research Network (CRN), a consortium of managed care organizations, leverages its participants' strong data collection systems to identify important trends on the delivery of care in the community setting. Over the last several years, for example, CRN studies have produced important details about mammography, prophylactic mastectomy, and cervical cancer screening.
DCCPS is also home to the Tobacco Control Research Branch, a leader in our nation's battle to continue to reduce rates of tobacco use, and to NCI's Office of Cancer Survivorship, which is supporting the critical efforts to more fully detail the long-term impact of treatment on survivors and develop interventions to help survivors cope with the unique challenges they face. And DCCPS' programs focused on energy balance, molecular epidemiology, and dissemination have also been and will continue to be tremendously valuable.
Importantly, DCCPS has been at the forefront of NCI's efforts to leverage the expertise and resources of other NIH institutes, federal health agencies, and nongovernmental organizations.
DCCPS has come to stand as the nation's model for cancer control science. As NCI plans for the next decade, DCCPS will continue to play a critical role in addressing the Institute's strategic scientific priorities.
Dr. John E. Niederhuber
New Guidelines on Cervical Cancer Screening Released
Experts convened the 2006 conference to incorporate new evidence on the natural history of cervical precancer and of HPV infection, the major cause of cervical cancer worldwide, into the previous guidelines issued in 2001. For example, explains Dr. Diane Solomon, medical officer in NCI's Division of Cancer Prevention and one of the authors of the new guidelines, "there is [now] recognition that young adolescent women are at high risk of being infected with HPV, but it's also very likely that HPV and any associated cellular changes will clear over time. In addition, these young women are at exceedingly low risk of cervical cancer. Therefore, one major change in these guidelines is to manage adolescent women who have an abnormality very conservatively, and follow them, unless they have evidence of severe precancer."
An accompanying clinical opinion article puts the new guidelines in the context of risk management, in which the results of any given test are not used alone to decide the next step for a woman diagnosed with a cervical abnormality, but integrated with additional information to gain a more accurate estimate of the likelihood that a cervical precancer or cancer is present. "I think these guidelines represent a significant step towards the concept of management according to risk strata," says Dr. Mark Schiffman, epidemiologist with NCI's Division of Cancer Epidemiology and Genetics (DCEG) and co-author of the clinical opinion article led by Dr. Philip Castle, also of DCEG.
Stem Cells, miRNA Influence Breast Cancer Metastasis in Mice
Two studies led by investigators from the Massachusetts Institute of Technology have identified mechanisms by which breast cancer cells in mice gain the ability to metastasize.
One study, published in the October 4 issue of Nature, found that mesenchymal stem cells (MSCs), which normally reside mainly in the bone marrow, can migrate to breast tumors in mice, likely in response to signaling from the cancer cells that is similar to that from injured normal tissue. Once in the tumor microenvironment, the MSCs release a protein called CCL5, which appears to influence the later steps of metastasis, including the movement of cancer cells from the bloodstream to adjacent tissue.
The influence of the CCL5 protein required the MSCs to be in close proximity to the cancer cells before they metastasized. When the investigators injected mice with a mixture of MSCs and human breast cancer cells, the mice developed tumors that spread to the lungs and other tissue sites. However, the MSCs did not metastasize along with the cancer cells, and cancer cells taken from the lung nodules failed to form tumors with elevated metastatic potential compared with cells taken from the original primary tumors.
The second study, published online September 26 by Nature, suggests a role for microRNAs (miRNAs) in breast cancer metastasis. The investigators focused on a specific miRNA, called miR-10b, which was found by microarray analysis to be expressed only in metastatic cancer cells.
When the investigators forced the expression of this miRNA in otherwise nonmetastatic human breast cancer cells injected into mice, the cancer cells formed tumors that were both highly locally invasive and metastatic. In contrast, control cancer cells not forced to express miR-10b did not invade local tissue or enter the bloodstream.
"I started looking at how the stromal microenvironment of a tumor regulates cancer cell metastasis, and Dr. Ma [author of the miRNA paper] started looking at the genetic material within the cancer cell itself that drives metastasis," explains Dr. Antoine Karnoub, lead author of the stem cell study. "Metastasis doesn't have to be [driven by only] one or the other - it could very well be a combination of both."
New Targeted Agent Shows Efficacy in Advanced Kidney Cancer
An experimental multitargeted antiangiogenesis agent has demonstrated promising activity in patients with advanced kidney cancer for whom a similar targeted drug failed to work. Speaking late last month at a large European cancer research conference, ECCO 14, Dr. Brian Rini from the Cleveland Clinic Taussig Cancer Center reported that, in a phase II clinical trial, the experimental tyrosine kinase inhibitor axitinib shrunk tumors in more than half of the 62 trial participants.
"Preliminary analysis shows that progression-free survival was on average more than 7.7 months," Dr. Rini said in a news release. "We think these results are impressive because these patients were heavily pretreated with drugs thought to be similar to axitinib."
All of the patients in the trial had metastatic renal cell carcinoma (RCC) and had not responded to sorafenib (Nexavar), which received FDA approval in December 2005 for the treatment of metastatic RCC. Of the 14 patients in the trial who had also been treated with another tyrosine kinase inhibitor approved by the FDA for the treatment of advanced RCC, sunitinib (Sutent), only 1 had a partial response, Dr. Rini reported.
Axitinib - which inhibits vascular endothelial growth factors 1, 2, and 3 in an intracellular signaling pathway regulated by a gene known as VHL - has also shown encouraging activity in patients with advanced pancreatic, lung, and thyroid cancer. (Clinical Trials for axitinib now enrolling patients.)
"These results of a novel agent targeting the VHL pathway in clear cell renal carcinoma are certainly interesting," says Dr. Marston Linehan, chief of the Urologic Oncology Branch in NCI's CCR, who, along with Dr. Berton Zbar, discovered the VHL gene. "Since there is currently no clear choice for second-line therapy in advanced clear cell renal carcinoma, this agent has the potential to fill that role."
Experimental Agent Improves HRPC Survival in Early-Phase Trial
In a secondary analysis of a recently completed phase II trial, an experimental agent for the treatment of men with a difficult-to-treat type of prostate cancer improved overall survival compared with placebo, even though there was no improvement in progression-free survival, the trial's primary endpoint.
"It is usual to use [progression-free survival] as an endpoint in phase II studies; however it can be difficult to measure accurately in patients with metastatic hormone-resistant prostate cancer (HRPC)," said the trial's principal investigator, Dr. Nick James from the U.K.-based Institute for Cancer Studies. "Overall survival is an unambiguous endpoint and clearly an important outcome for patients."
Patients in the randomized, double-blind trial - the results of which were presented late last month at the ECCO 14 conference in Barcelona - had metastatic HRPC, a disease for which only one chemotherapy agent, docetaxel, is currently approved. The drug used in this trial, ZD4054, is an endothelin A receptor antagonist. Studies have suggested that the endothelin A receptor molecule plays important roles in the inhibition of apoptosis, promotion of angiogenesis, and cancer cell invasion and metastasis.
Patients in the trial who received the 10 mg dose of ZD4054 fared best, with a median overall survival of 24.5 months, while patients who received the 15 mg dose of ZD4054 or placebo had a median overall survival of 23.5 and 17.3 months, respectively.
"The results look promising," said Dr. Boris Freidlin, division of NCI's Division Cancer Treatment and Diagnosis, noting the consistent overall survival improvements.
Based on the results, AstraZeneca, the drug's manufacturer, is launching three phase III trials using ZD4054 in men with HRPC. NCI is sponsoring a phase III trial, being led by the Southwest Oncology Group, of a different endothelin A receptor antagonist in a similar patient population.
October 1 marked the start of fiscal year (FY) 2008; however NCI and NIH must wait for Congress and the White House to negotiate spending priorities before the year's appropriations bills are finalized. The federal government is currently operating under a Continuing Resolution, which will maintain federal funding at FY07 levels through November 16, when either the FY08 appropriations bills will be enacted into law or a second Continuing Resolution will be needed. At issue is the fact that Congress has put together discretionary spending bills which total $23 billion more than the $933 billion budget request that the President sent to Congress in February. The White House has issued Statements of Administration Policy on 7 of the 12 appropriations bills, including Labor-HHS-Education, which state that the bills would appropriate funds in excess of the President's budget request and therefore would be vetoed.
The Labor-HHS-Education appropriations bill, HR 3043, that the House passed in July provides $151.7 billion, $10.8 billion more than the $140.9 billion requested by the President for the programs covered under this bill. Under the House-passed bill, NIH would receive $29.4 billion for FY08, of which NCI would receive $4.87 billion. The Senate has stated that it would take up its version of the Labor-HHS-Education appropriations bill (S 1710) during the week of October 15. The Senate bill contains $149.9 billion in spending and would provide NIH with $29.6 billion, including $4.91 billion for NCI. Under the President's budget request, NIH would receive $28.6 billion and NCI would receive $4.78 billion for FY08.
As of October 1, the House had passed each of the 12 appropriations bills, while the Senate had passed 4 of the 12 (Homeland Security, Military Construction-VA, State-Foreign Operations, and Transportation-HUD).
In addition to appropriations, there are other legislative activities of interest to NCI in Congress. NCI's Office of Government and Congressional Relations is closely tracking the Family Smoking Prevention and Tobacco Control Act (S 625/HR 1108) along with two bills that would affect the Small Business Innovation Research (SBIR) Program - The Small Business Act Amendment (S 1932) and The Small Business Investment Expansion Act of 2007 (HR 3567). HR 3567 was passed by the House on September 27. Each of the small business bills could potentially affect the pool of grant applicants being supported by NCI. The small business legislation would impact both the pool of available funds set aside for small businesses and the eligibility criteria for small business grant applicants.
Survival & Mortality: Measuring the Burden of Cancer
Survival statistics and mortality statistics may seem like opposite sides of the same coin, but they provide distinct types of information. One is tied to death, and the other to a diagnosis of cancer. Mortality is a count of cancer deaths in the population during a given calendar period. Survival measures how long a person is alive after diagnosis.
Clinicians and patients tend to be interested in survival statistics because they contain information relevant to prognosis and treatment. NCI's Surveillance, Epidemiology, and End Results (SEER) program has collected data on survival by cancer type and extent of disease for decades. Today, the information can guide both clinicians and patients.
"Survival statistics are being used to help inform patients about their disease," says Dr. Brenda K. Edwards, associate director of the Surveillance Research Program in NCI's DCCPS.
"We know more today about identifying, diagnosing, and characterizing cancer, and this complicates our comparisons of survival statistics for some cancers over time," she continues. "But knowing more about the disease and how to treat it will lead to better outcomes for patients."
For instance, a diagnosis of early-stage breast cancer today may not be the same as one a decade ago because of advances such as the discovery of the HER2 gene's role in some breast cancers and the development of trastuzumab to treat HER2-positive disease.
Clinical trials often use survival to measure the effects of an intervention on individuals randomly assigned to one group or the other.
"Survival is a metric we use in treatment studies because everyone is the same at the beginning of the study, and then you give them drug A or drug B," says Dr. Peter Bach of Memorial Sloan-Kettering Cancer Center. "This is reasonable because you assume no biases at the beginning."
While survival data have many applications, they have to be considered carefully. Survival is keyed to the year of diagnosis, and anything that advances the time of diagnosis, such as screening programs and improved access to care, may make survival look better than it really is.
Detecting cancers that would never have caused any harm, known as overdiagnosis, can inflate survival rates. For example, the widespread introduction of prostate-specific antigen testing for prostate cancer has likely led to overdiagnosis and artificially boosted prostate cancer survival rates.
"Survival statistics have limitations and should be used with caution," notes Dr. Edwards. "You need to know what survival tells us and what it doesn't."
Some experts caution against using survival as a measure of progress. Comparing survival across time or between geographic locations can be problematic because patterns of diagnosis are likely to differ.
These differences change the timing of diagnosis and may make the comparisons invalid, notes Dr. Steven Woloshin of the Dartmouth Medical School, who has written about survival and mortality rates.
"Five-year survival rates can provide useful information about prognosis," says Dr. Woloshin. "But 5-five-year survival is not a reliable metric for showing whether there has been progress against cancer."
As a panel of experts convened by NCI concluded in 1990, mortality rates are the most important measure of progress against cancer. But like survival rates, they can be problematic. The accuracy of mortality rates depends on how death is determined, and this may be complicated if a patient has other health conditions such as diabetes or dies from another cause.
Nonetheless, says Dr. Woloshin, "there's no question that of all the measures we have of measuring success in cancer, mortality is the one to hang your hat on."
—Edward R. Winstead
Much has changed in DCCPS over the past decade. Here, Dr. Barbara Rimer, the division's first director, currently the dean of the University of North Carolina School of Public Health, and Dr. Bob Croyle, the current division director, talk about the past and future of DCCPS.
The formation of DCCPS brought together a broad array of research interests. What was the biggest challenge in pulling it all together?
Was there a specific focus of the division or certain areas that were higher priorities than others?
What things from the division's early years are you particularly proud of?
We hear a lot about the rapid changes in cancer research. Is that true for the population sciences and is it influencing how DCCPS is preparing for the future?
Are there specific areas of research that DCCPS is funding that could have profound implications for treatment, early detection, etc.?
Looking ahead, what do you believe are the trends that will drive DCCPS' future work and priorities?
Regional Chemotherapy for Inoperable Liver Metastases
Name of the Trial
Principal Investigator
Why This Trial Is Important
In IHP, the flow of blood into and out of the liver is temporarily isolated from the body's circulatory system and high doses of anticancer drugs, such as melphalan, are infused directly into the liver through the hepatic artery. This technique allows the delivery of high doses of chemotherapy to liver metastases while sparing the rest of the body from drug exposure.
In this trial, doctors are testing a type of IHP called percutaneous isolated hepatic arterial perfusion (PHP) in patients with liver metastases from ocular (eye) or cutaneous (skin) melanoma. In PHP, catheters inserted through the skin are used to deliver drugs to the liver, block the flow of blood from the liver, and then remove the drugs. In contrast with IHP, this technique avoids the complications of major surgery and can be repeated if necessary.
"With this study, we're comparing treatment with systemic chemotherapy versus a minimally invasive method of delivering chemotherapy regionally to the affected organ," said Dr. Pingpank. "We hope to establish regional chemotherapy as a standard of care for patients with metastatic ocular melanoma, a disease for which no standard therapy currently exists."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Following are newly released NCI research funding opportunities:
Research on Research Integrity
This is a renewal of RFA-NR-07-001 and will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3775. Inquiries: Dr. Ann O'Mara - email@example.com
Research on Research Integrity
Researchers Drs. Douglas Lowy and John Schiller in NCI's CCR recently received the Federal Employee of the Year award from the Partnership for Public Service. At a Washington, DC, gala held in their honor, the Partnership for Public Service presented nine Service to America Medals to outstanding civil servants for their high-impact contributions critical to the safety, health, and well-being of Americans. The top medal went to the NCI scientists for their contributions to the development of the first human papillomavirus vaccine. In accepting the Service to America Medals, the researchers said they hope to continue to try to develop improved and less expensive second-generation versions of the vaccine.
Egorin Receives First Michaele Christian Lectureship
If Memory Serves...
Early on, some members of the National Advisory Cancer Council had reservations about placing NCI within the administrative structure of the Public Health Service (PHS); they thought that the Veterans Administration was a better fit. But U.S. Surgeon General Thomas Parran prevailed in his choice of the PHS partly because two cancer-focused research programs already existed within this governance: a group in Boston and another in Washington, DC. (Read more)
For more information about the birth of NCI, go to http://www.cancer.gov/
New SEER Monograph Details Cancer Survival among Adults
NCI recently released SEER Survival Monograph: Cancer Survival Among Adults: U.S. SEER Program, 1988-2001, Patient and Tumor Characteristics, which examines cancer survival by patient and tumor characteristics for more than 1.6 million adult cancers diagnosed during 1988-2001. Survival data are from NCI's Surveillance, Epidemiology, and End Results (SEER) Program and represent cancer in approximately one-fourth of the U.S. population. The tumor characteristics may include subsite, size of tumor, extension of the tumor, positive lymph nodes, distant metastases, and histologic type. The patient characteristics are age, race, and sex.
The monograph is available online at http://www.seer.cancer.gov/publications/survival/, where instructions for ordering print copies can be found.
OIA Director Recognized for Middle East Work
Weights and Measures: How DCCPS is Improving Behavior Observation
On the outskirts of a rural Midwestern town, a man steps through the door of a trailer, which, along with three other connected trailers, forms a large, mobile medical facility. Earlier in his home, researchers had asked him about his medical history and lifestyle; now in the trailers, they analyze his blood, measure his height and weight, and assess his cardiovascular fitness on a treadmill, among other tests.
A few hours later, he walks out with a special device attached to a belt under his shirt that records how much he is moving, including the acceleration of his motion, so researchers can tell the difference between activities like walking and running. He wears it when he's awake for 1 week, then slips the device into a padded envelope and drops it in the mail. The trailers are gone, on their way to another city.
Welcome to just one person's experience participating in the National Health and Nutrition Examination Survey (NHANES), a Centers for Disease Control and Prevention program that is cosponsored by NCI's DCCPS. DCCPS supplied the measurement device, called an accelerometer, one of a host of new tools the division is using to improve the data collected from behavioral research studies.
"Technology such as this can be used in 1, 10, or thousands of people to understand more comprehensively the variety of factors that impact cancer incidence," explains DCCPS Director Dr. Robert Croyle. "It can also be used to monitor the quality of cancer care, and to improve communication between patients and their health care providers."
The concept of remote devices to record health information is not new, notes Dr. Audie Atienza, a program director in the DCCPS Health Promotion Research Branch and co-editor of a new book on the subject, The Science of Real-Time Data Capture. "In the 1970s, cardiovascular medicine researchers assessed the ambulatory heart rates of patients in real-time using remote technology," he says, "but now it's extending into other domains, such as cancer, and the technology is becoming much more powerful and portable. As a result, multiple aspects of health and disease can now be measured in real time and in the real world."
The benefit of these tools is that they improve accuracy by reducing human error. And that's extremely important, says Dr. Richard Troiano, an epidemiologist in the DCCPS Applied Research Program who works on the project, because accurate measurement of peoples' behaviors and other risk factors is essential to understanding what really causes cancer and how it can be prevented.
In the physical activity component of the NHANES project, for example, "we found a striking difference between what people said that they were doing and what we were able to measure them doing with the accelerometers," Dr. Troiano explains. "Survey participants reported much more physical activity than we measured during the time they wore the accelerometer."
Meanwhile, as part of the recently launched NIH-wide Genes, Environment and Health Initiative, grantees are developing a cell phone equipped with camera, image processor, and voice recognition to assess diet; a cell phone integrated with a miniaturized accelerometer, heart rate monitor, and GPS device to assess physical activity; and a cell phone coupled with an e-watch that allows for real-time assessment of psychosocial stress, explains Dr. Jill Reedy, who oversees the division's participation in the initiative.
Clearly, Dr. Croyle says, technology is changing the whole field.
—Brittany Moya del Pino


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Dr. Rajiv Shah serves as the 16th Administrator of USAID and leads the efforts of more than 8,000 professionals in 80 missions around the world.
Margaret Sullivan serves as USAID's Acting Chief Operating Officer as well as Chief of Staff, having joined the Agency in 2011.
Stephen O'Connell was appointed as the USAID's Chief Economist in early 2014.
Mark Feierstein is serving as the associate administrator at the U.S. Agency for International Development.
Carla Koppell is the United States Agency for International Development (USAID) Chief Strategy Officer (CSO).
Last updated: June 06, 2012


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The Spring Show 2014 photo gallery is coming soon!
As we countdown, take a look back at student work from our Spring Show archives.
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posted on 08/25/14 in: Athletics, Event News
The 5th annual Academy of Art Golf Classic is set for Oct. 24 at The Course at Wente Vineyards. Sponsor, donate, participate!


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Page Last Modified: August 7, 2008


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Changing Time
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2,671 reviewer rep
343 forum posts
joined Feb 16, 2012
31-year-old female backpacker
Columbia, SC
Email: private
Gear Reviews (23)
|Sea to Summit Aeros Premium Pillow
|Mountain Hardwear Optic 2.5
|Snow Peak Mola Headlamp
|Sierra Designs Women's Mobile Mummy 800 3-Season
|Sierra Designs Women's Mobile Mummy 800 2-Season
|Bergans Rondane 6L
|Sierra Designs Women's Stretch DriDown Hoody
|Bergans Compact Light 2
|Big Agnes Q-Core
|Patagonia Women's R1 Pullover
Forum Posts (343)
|Re: Oregon Coast Day-Hikes
|September 15, 2014
|Re: Guadalupe Mountains National Park
|September 15, 2014
|Re: Scotland - Ben Nevis overnighter
|September 15, 2014
|Re: Rendezvous Mountain
|September 15, 2014
|Re: Kathleen Wins $100 Backcountry Gift Card, One to Go
|September 1, 2014
Trip Reports (21)
|Our Great Northeastern Adventure: The White Mountains - Crawford Notch State Park and Franconia Notch State Park
|July 11, 2014
|Jackson Hole, Yellowstone National Park, and Grand Teton National Park
|March 14, 2014
|Pisgah National Forest, NC Fall Foilage
|October 2, 2013
|Sequoia National Park
|July 25, 2013
|The Half Dome Experience
|July 9, 2013
I am from the Midlands of South Carolina. I love being outside! I enjoy hiking, backpacking, golfing, disc golfing, kayaking, wakeboarding, snowboarding, playing tennis and softball, running, and working out at the gym. I try to go hiking at least once a month, but sometimes I go more often. The closest mountains are 2.5 hours from me, so I am not able to go as often as I'd like. I have been backpacking for about four years now. I primarily hike in Western NC, but I also venture to North Georgia, East Tennessee, Southwest and Central Virginia, and Upstate SC. My husband and I got married in 2011 in Yosemite National Park. We spent our honeymoon in YNP and in Mammoth Lakes. That was the best trip of my life!
Favorite Backcountry Spots:
Yosemite National Park and the Ansel Adams Wilderness are my top overall favorites, but my favorite East Coast spots are Max Patch Bald and Black Balsam Knob in NC, Grayson Highlands State Park in VA, Roan Highlands and Great Smoky Mountains National Park in TN, and Jones Gap State Park in SC.
Trip Reports:
http://www.trailspace.com/forums/trip-reports/topics/144529.html#144529 Hot Springs, NC to Rich Mountain
http://www.trailspace.com/forums/trip-reports/topics/136978.html Chimney Tops, GSMNP
http://www.trailspace.com/forums/trip-reports/topics/130708.html Mt LeConte, GSMNP
http://www.trailspace.com/forums/trip-reports/topics/130697.html Clingman's Dome to Andrews Bald, GSMNP
http://www.trailspace.com/forums/trip-reports/topics/126027.html Smokemont to Cosby, GSMNP
http://www.trailspace.com/forums/trip-reports/topics/134764.html Max Patch Bald, NC
http://www.trailspace.com/forums/trip-reports/topics/128359.html Another Max Patch Bald trip
http://www.trailspace.com/forums/trip-reports/topics/126002.html Roan Highlands, TN
http://www.trailspace.com/forums/trip-reports/topics/125169.html The Mist Trail, Yosemite NP
http://www.trailspace.com/forums/trip-reports/topics/125506.html My Wedding at Glacier Point, Yosemite National Park
http://www.trailspace.com/forums/trip-reports/topics/135970.html Central VA
http://www.trailspace.com/forums/trip-reports/topics/134709.html Pisgah National Forest, NC
http://www.trailspace.com/forums/trip-reports/topics/131431.html Grayson Highlands State Park, VA
Tent - MSR Carbon Reflex 2, REI Half Dome 2
Pack- Gregory Deva 60L, Osprey Aura 50, Gregory Cirque 30L
Sleeping bag - Montbell U.L. Spiral Down Hugger #1, Montbell U.L. Spiral Down Hugger #3
Compression Sack - Sea to Summit eVent (M)
Liner- Sea to Summit Reactor
Camp Seat/Chair - Big Agnes SL Cyclone, Thermarest Trail Lite Seat
Pad - Big Agnes Insulated Q-Core, Big Agnes Insulated Air Core
Pillow - Exped Comfort Foam
Stove - Jetboil PCS
Poles - Black Diamond Distance Z-poles (100 cm)
Filter - Katadyn Vario, Sawyer Squeeze
Light - Petzl Tikka 2, Black Diamond Orbit, ENO Twilights
Multi-tool - Gerber Steady, Gerber Crucial
Boots/shoes - Merrell Moab Mid GTX, Asolo FSN 70 GTX, Salomon XA Pro 3D Ultra GTX, Kahtoola Microspikes
Puffy - Montbell Alpine Light Jacket, Patagonia Nano Puff, Arc'teryx Atom LT, Patagonia Hi-Loft Down Sweater, Patagonia U.L. Down Jacket, Patagonia Down Sweater Vest, The North Face Zephyrus
Rain shell - Mountain Hardwear Typhoon, Patagonia Torrentshell, Patagonia Nano Storm, Mountain Hardwear Xenon
Baselayers: Smartwool Midweight Pattern 1/4 zip and pants, Patagonia R1 pullover and pants, Patagonia Capilene 2 &3 tops, Patagonia Merino 2 1/4 Zip, Outdoor Research Essence 1/4 Zip, Smartwool PHD Mini socks
Gaiters: Outdoor Research Rocky Mountain Low
Bear Canister - Bearvault BV450
Hammock - ENO Double Nest with Slap Straps Pro and Dry Fly Tarp
Beverage Container - GSI Outdoors Infinity Insulated Mug, 32 oz Nalgene, 32 oz Platypus bottle, .5 liter Platypus bottle
Bladder - 2L Camelbak, 3L Platypus Big Zip
Here is a link to my Reviewer of the Month story, done by Seth Levy:
|Torso Length
|Boot/Shoe Size
|Jacket/Shirt Size
|Pant Size


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For a lone wolf, the Water Bearer sure likes to have a lot of people around. Aquarians are humanitarians above all else, idealistic in their beliefs and ardent pursuers of causes. Non-profit organizations and trade unions would be a natural for them -- anything that will help the greater good. This unconventional rebel-with-a-cause cares so deeply about his fellow man that the quest for knowledge and answers is never-ending.
The mentally-quick Water Bearer enjoys a challenge and anything at a rapid-fire pace, whether it's a team meeting or a battle of bantering wits. Aquarians are firm in their beliefs -- they've spent plenty of time thinking about them -- and are bound to get the job done. Their inquisitive nature always has them considering what's new, different and mysterious and how these things can help people in the future. Is the Water Bearer a pioneer or a renegade? Perhaps a bit of both, but there's no doubting that they see the world in their own unique way!
The old 'company man' mold is given a firm boot by Aquarians. To them, that world is inconceivable, a total waste of resources. The Water Bearer wants no boundaries and to be able to continually push the envelope -- now that's living! And working, since it's part of the plan. Aquarians will spend countless hours mulling over the possibilities for a project and may even come up with some startling conclusions, but it's all in a day's work. And it's never boring! A dull day is a nightmare for the energetic Water Bearer.
The Aquarius office is probably Zen-like in character, with a low working table and cushions all around for its occupant and guests (remember, everyone is an equal member of the team). That futuristic clock in the corner was probably made by the Water Bearer. An electric car or the newest Beetle would provide loads of fun and make for a handy-dandy way to get to lunch at an avant garde spot with stunning world food and delectable Rainforest Crunch.
Aquarians are well-suited as inventors, politicians, writers, scientists, astronauts, artists and, you guessed it, astrologers!
Get moving fast on the path to success with a free sample Career Path Reading from Astrology.com.
*DISCLAIMER*: The information contained in or provided through this site section is intended for general consumer understanding and education only and is not intended to be and is not a substitute for professional advice. Use of this site section and any information contained on or provided through this site section is at your own risk and any information contained on or provided through this site section is provided on an "as is" basis without any representations or warranties.


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Browse the latest stories and reports on MSF from various media outlets.
- Advocacy Work Remove Advocacy Work filter (-)
MSF's Leena Menghaney explains that the Trans-Pacific Partnership trade agreement would limit access to medicine by preventing the manufacture of affordable generic drugs.More >
U.S. proposals in the Trans-Pacific Partnership trade talks will make lifesaving medicines unaffordable for many people who need them, MSF warns.More >
India's Supreme Court is expected to rule on a case with major implications for the global supply of generic medications. MSF's Leena Menghaney and Petros Isaakidis warn about the potential consequences for patients.More >


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Seating Tax at the Strategy Table
July, 2014
Tax professionals should have more input into strategic decisions, say finance chiefs.
The New Word on ERP
July, 2014
The cloud, compliance, and consumerization are just three of the trends changing today's midmarket enterprise resource planning systems.
Rethinking Buybacks
July, 2014
To earn a "return" on stock buybacks, you need a more sophisticated message and better execution.
Running in Place
July, 2014
The working capital performance of America's largest companies is flat for the third straight year, according to the 2014 CFO/REL Scorecard.
Once More Unto the Fiduciary Breach
July, 2014
A class-action suit highlights potential fiduciary risks for 401(k) plan sponsors.
A Split Decision on Cash
July, 2014
The Duke/CFO Magazine Global Business Outlook Survey shows finance chiefs in some regions deciding that they can afford to invest again in growth.
Some Vacation
July, 2014
In July, thoughts turn to vacation — or the lack thereof.
Road Show
June, 2014
A web site and data company for automobile buyers seeks to raise capital from the public markets.
Predictive Analytics: How Clear Is the ROI?
June, 2014
Companies claim that predictive analytics has earned them rich returns on their investments, but the numbers may not be as solid as they appear.
Reinventing Innovation
June, 2014
To gain an edge in a reviving economy, companies are looking for little ideas that can create big value.
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Porter in NV
So far these replacements for my tubes work great and don't even have a problem with them at 90mph on my WR450. However the install was very difficult and required me and a buddy to do it because the trick is to keep the whole tire in the center of the rim (used clamps to do this). The instructions were not very clear, however if you can manage to get them on the rim it is a great product, but make sure that your local shop will install them before ordering. As far as traction, it is noticeably better and absorbs more rocks than I thought it would. Great for desert riding.Read All Reviews


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Daniel Hartley |
Research Economist
Daniel Hartley is a research economist in the Research Department of the Federal Reserve Bank of Cleveland. He is primarily interested in urban/regional economics and labor economics. His current work focuses on crime, public housing, and neighborhood housing market dynamics.
He completed his PhD at the University of California, Berkeley. He has an M.B.A. in economics and finance from the University of Chicago and an M.Eng. and a B.S. in electrical engineering from the Massachusetts Institute of Technology.


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I wasn't sure how to put the back-of-the-throat sound required for the Welsh pronunciation into text.I just didn't want people pronouncing it "Cotch"."Cosh" is close enough
Haven't held a
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this journalAlthough
appreciated, it i...
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Dear, deviantart
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(check also the 1st
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me and I hope that
these resources
might be helpful for
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channel by Will
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is a cartoonist and
his vi...
Hey everyone~!
:la:First of all,
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because it's my
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hello dear
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Slow and steady pretty much sums up a Taurean on the road. The Bull is a careful planner, knowing full-well what is needed to make a trip both successful and worth their time. Taking a trip is no small task for these folks, which means they wouldn't think twice about spending a year planning the perfect excursion, poring through a stack of travel books while they're at it.
Does this mean a trip with the Bull will wind up being 'my way or the highway?' Hey, they don't call them bull-headed for nothing! That said, pampered (and pampering) Taureans are likely to set an agenda which is rife with sensual pleasures - top hotels, great meals and a night at the opera are all to be expected. Even the luggage will be top-of-the-line, whether it's a Louis Vuitton trunk or a sturdy Eastpak bag.
The Bull will also spend a pretty penny while on the road, although probably not more than the bank account can handle. Is it likely that Taureans will wait a lifetime for that six-month whirl through Europe? Maybe. But for these folks, the trip will be everything they want (and need) when they finally get there!
Discover Daily Illumination -- a great tarot reading to start or end each day. Click here for a free sample from Astrology.com.
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- News
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To many fans, European professional cycling is broken down and defined by seasons, most centered on an important event or series. May has the Tour of Italy. July means it must be time for the Tour de France. And August brings the Tour of Spain.
While many of us spend the winter months dreaming of longer days, sunshine, smooth roads, and warm temperatures, a special breed of cyclist yearns for gray skies, rough roads, and, yes, cold. These riders spend their winters targeting the first few months of the season and a series of legendary races, many with hard-to-pronounce names, known as the Spring Classics.
So with spring so close, there's no better time to tell you everything you need to know about these fantastic, dramatic, keep-you-on-the-edge-of-your-seat races.—Whit Yost