text:
Master Protein Controls Multiple Myeloma Cells
Despite the constellation of abnormal genetic changes that drive multiple myeloma, these cancer cells are controlled by a single protein, researchers reported online in Nature this week.
The study suggests that multiple myeloma cells are dependent upon the cancer-promoting genetic activities controlled by a protein called IRF4. It further suggests that breaking their "addiction" to this protein could possibly treat the disease.
In 10 different laboratory models of multiple myeloma, Dr. Louis M. Staudt of NCI's Center for Cancer Research and his colleagues found that interfering with the production of IRF4 caused the myeloma cells to die. Read more
Outreach Improves Breast Cancer Detection in African Americans
African American women face a greater risk of death from breast cancer, in part because they tend to be diagnosed at later stages of the disease than white women. New findings published online today in Cancer suggest that this disparity in stage of diagnosis can be reduced, using a program that pairs educational outreach to the community with patient navigators who advise and guide diagnosed patients.
Dr. Sheryl G. A. Gabram and colleagues analyzed data from breast cancer patients, 89 percent of whom were African American, treated between 2001 and 2004 at the Avon Foundation Comprehensive Breast Cancer Center at Grady Memorial Hospital in Atlanta. During that period, 125 trained community health advocates (CHAs) conducted more than 1,000 interactive presentations to increase awareness and encourage breast self-examinations and screening mammography at churches, schools, workplaces, and health fairs in the communities from which the hospital draws many of its patients. Twenty CHAs received further training as patient navigators and helped diagnosed patients maximize their use of services and treatments. Read more
Master Protein Controls Multiple Myeloma Cells
Despite the constellation of abnormal genetic changes that drive multiple myeloma, these cancer cells are controlled by a single protein, researchers reported online in Nature this week.
The study suggests that multiple myeloma cells are dependent upon the cancer-promoting genetic activities controlled by a protein called IRF4. It further suggests that breaking their "addiction" to this protein could possibly treat the disease.
In 10 different laboratory models of multiple myeloma, Dr. Louis M. Staudt of NCI's Center for Cancer Research and his colleagues found that interfering with the production of IRF4 caused the myeloma cells to die.
"We were surprised to find that multiple myeloma cells with many different genetic abnormalities were all exquisitely sensitive to IRF4 inhibition," says Dr. Staudt. "This suggests that therapeutic targeting of IRF4 might be broadly effective in this disease."
The IRF4 protein, a transcription factor that regulates the activity of multiple genes, is normal in most myeloma cells. But it acquires an expanded genetic repertoire and directs a broad program of activity, including genes that are active in cell metabolism and other basic functions. The loss of IRF4 in myeloma cells, then, results in widespread disruptions to these essential functions, a process the researchers call "death by a thousand cuts."
Multiple myeloma is a cancer that involves a type of white blood cells called plasma cells, which are antibody-producing cells that develop from the immune system's B cells.
The disease currently has no cure, but patients may benefit from chemotherapy, stem cell transplantation, or newer treatments such as bortezomib (Velcade) or thalidomide.
To discover the role of IRF4, the researchers screened a genetically diverse collection of myeloma cells for "essential" genes using a technique known as RNA interference. They observed the dependence on IRF4 in myeloma cells across genetic subtypes of the disease.
The list of oncogenes regulated by IRF4 in myeloma cells includes MYC, which plays an important role in multiple myeloma and other cancers. In an unexpected finding, IRF4 and MYC form a feedback loop: IRF4 activates MYC, and MYC, in turn, activates IRF4, as well as abnormal gene networks regulated by IRF4.
The study is an example of so-called "non-oncogene addiction." In this situation, cancer cells become dependent on the activity of a gene that does not have mutations or other hallmarks of oncogenes.
Based on studies of mice with a form of IRF4 and laboratory experiments, the researchers are hopeful that a therapeutic window may exist in which treatments directed at the production of IRF4 might kill myeloma cells while sparing normal cells.
Transcription factors are considered challenging molecules to inhibit, but recent success in targeting the transcription factors p53 and BCL-6 "provides hope that IRF4 can be exploited as the Achilles' heel of multiple myeloma," the researchers note.
—Edward R. Winstead
Outreach Improves Breast Cancer Detection in African Americans
African American women face a greater risk of death from breast cancer, in part because they tend to be diagnosed at later stages of the disease than white women. New findings published online today in Cancer suggest that this disparity in stage of diagnosis can be reduced, using a program that pairs educational outreach to the community with patient navigators who advise and guide diagnosed patients.
Three years after the program was launched, a cross-sectional study of all breast cancer patients at the primary community hospital showed that the proportion of women diagnosed with in situ breast cancer doubled, while those diagnosed with stage IV breast cancer fell by more than a third.
The authors believe the results have "implications on prognosis, and ultimately outcome, for these women if recommended treatment guidelines are followed." They note that the cross-sectional study design could not definitively prove that the intervention caused the shift in stage of diagnosis they observed, but they are continuing prospective work to link the effect of CHAs and patient navigators to particular patient outcomes.
Osteopontin Helps Tumors Harness Bone Marrow Cells for Growth
Researchers at the Whitehead Institute for Biomedical Research and their colleagues have shown that the protein osteopontin, released by breast carcinoma cells, can induce the growth of distant, inactive tumors through the recruitment of bone marrow cells (BMCs). Their report appeared June 13 in Cell.
The investigators injected mice with an indolent (slow-growing) breast cancer cell line in one flank, and in the other flank they injected either one of two vigorously growing breast carcinoma lines for the test group or a placebo of matrigel, the liquid vehicle used to support cells for injection, for the control group.
Mice in the test group showed approximately 10 times the tumor growth in the indolent cells as control mice that received the placebo. The cause of the growth was not metastasis of the active cells to the indolent tumor site, but rather the recruitment of BMCs to tumors in both flanks, which in turn encouraged growth of the injected cells.
After analyzing the plasma levels of 80 known human cytokines, the investigators identified osteopontin as a necessary factor for recruitment of BMCs and subsequent tumor growth. Osteopontin is a glycoprotein involved in inflammation, angiogenesis, and metastasis, and has been found in higher levels in cancer patients with metastatic disease. However, when the researchers induced a cell line that does not normally express osteopontin to produce the protein, this alone was not sufficient to trigger tumor growth, indicating the involvement of other cellular factors.
"Our results provide evidence that bone marrow functional activation can be governed on a systemic level by endocrine factors that are released by certain instigating tumors," conclude the authors.
LYN Kinase May Contribute to Imatinib Resistance in CML
Imatinib (Gleevec), the standard treatment for chronic myelogenous leukemia (CML), works by targeting a protein called BCR-ABL, which is expressed only in leukemia or lymphoma cells. Unfortunately, many patients eventually become resistant to treatment with imatinib, and their cancer progresses. Mutations in BCR-ABL that occur over time account for some but not all cases of imatinib resistance, and researchers believe that other proteins may play a role.
In a study published online today in the Journal of the National Cancer Institute, investigators from the University of Texas M.D. Anderson Cancer Center and colleagues showed that persistent activation of a protein called LYN kinase may be one of the factors involved in imatinib resistance, independent of any mutations found in BCR-ABL.
The investigators tested both established, BCR-ABL-mutation-negative CML cell lines and patients with BCR-ABL-mutation-negative CML. In patients and cells sensitive to imatinib treatment, the drug suppressed the overactivation of LYN kinase; however, in imatinib-resistant cells and patients, LYN kinase remained activated after imatinib treatment. When LYN kinase activity was reduced - with gene silencing in the cells or with the drug dasatinib in patients - the cells died and the patients responded to treatment.
Interestingly, in imatinib-sensitive cell lines and cells taken from patients, the activation of LYN kinase appeared to be regulated by BCR-ABL, but not in imatinib-resistant cells.
Although the investigators cautioned that their cell samples were small, thereby restricting their ability to perform repeat analyses, their results "support the presence of…complex mechanisms of targeted drug resistance in CML patients. The association and mechanism of LYN activation in imatinib resistance warrants further study in additional patients," they concluded.
Mortality Risks Highlight the Effect of Smoking
Charts published June 18 in the Journal of the National Cancer Institute compare side-by-side an individual's chances of dying within 10 years from various causes according to age, sex, and smoking status.
Earlier versions of these charts were published 5 years ago by the same NCI-supported researchers, who are affiliated with the U.S. Department of Veterans Affairs and institutions in Vermont and New Hampshire; the new charts include updated mortality data and a revised algorithm to calculate the risks.
For current smokers, former smokers, and those who have never smoked, the researchers calculated age-specific risk of death (number of cases per 1,000 people) from heart disease; stroke; lung, colon, or prostate cancer; pneumonia; flu; AIDS; chronic obstructive pulmonary disease; accidents; and all causes combined. They used data from the National Center for Health Statistics and the U.S. Census Bureau.
Among the most striking trends in the charts are the fact that men of all ages are more likely than women to die in the next 10 years, and that smoking has the detrimental effect of adding about 5 years to the age of a woman and 10 years to the age of a man.
The charts are meant to help clinicians and patients discuss health risks, note the authors. "[They] provide two basic elements that people need if they are to make sense of the health threats they face: the magnitude of the risk and some context…[to] help people understand where to focus risk reduction efforts." The charts may be especially useful in smoking prevention and cessation efforts, they add.
More information from NCI on quitting smoking can be found at http://www.smokefree.gov and from the toll-free tobacco quitline at 1-800-QUITNOW (784-8669).
Guest Update by Dr. Julia H. Rowland
Cancer Survivorship Research Conference Maps New Challenges
It was very exciting and professionally gratifying for me to join the nearly 500 researchers, patient advocates, cancer care specialists, public health officials, and others at this year's fourth biennial cancer survivorship research conference held June 18-20 in Atlanta, GA. I remember attending the first such meeting in 2002, which was co-sponsored by NCI's Office of Cancer Survivorship in collaboration with the American Cancer Society's Behavioral Research Program. In 2006, the Lance Armstrong Foundation became a full partner as the meeting steadily expanded in scope.
I was struck by the dramatic growth and sophistication of the science presented during last week's meeting. It highlighted key topics and critical questions facing those living with a history of cancer and their caregivers and health care providers. It featured forward-looking research focusing on the unique physical, psychosocial, behavioral, and economic outcomes associated with cancer survivorship.
New findings and insights were presented by a growing cadre of investigators who are dedicating their considerable expertise, talent, and time in this still relatively young field of cancer research. This year, we received and considered 220 abstracts for presentation, a new record for the conference. We selected 12 of the top-ranked abstracts for podium presentations, revealing a wealth of new data and directions for future research.
One of the major plenary sessions focused on new directions in biobehavioral research. A chronic inflammation model proposed at this session could explain two of the most troublesome, persistent effects of cancer treatment - fatigue and depression. Another plenary delved into the burgeoning research examining the impact of cancer on family caregivers. We have only recently come to describe empirically the hidden costs (physical, psychological, and economic) of caregiving and the critical need to intervene not just with cancer patients but also with the family members and friends who provide the bulk of patients' long-term care.
The conference also served as a springboard for mapping out future research and clinical directions in this dynamic and fast-growing scientific area. For example, I was privileged to moderate a fascinating symposium on studies of new groups of cancer survivors: those surviving second cancers, recurrence, and advanced disease. As cancer becomes for many a chronic disease, this poses new challenges for us to address.
I was also drawn to the closing session on survivorship research and the media, which featured a lively dialogue with several well-respected print, radio, and TV journalists. I found the discussions and insider perspective very informative and hope the session will stimulate researchers to think about how to connect with the media and how we can promote the science of cancer survivorship, get more visibility for this work, and have our research results disseminated more widely.
The demand for such information is indicated by new data from NCI's Health Information National Trends Survey (HINTS), which show that 63 percent of cancer survivors report looking for cancer information, compared with only 27 percent of people with no personal or family history of cancer. We need to meet that rising demand with evidence-based information and interventions.
It is also clear that survivorship research is of growing interest to scientists, policy leaders, and clinicians around the country. It has been a focus of emphasis in recent years by the Institute of Medicine, the American Society of Clinical Oncology, leaders of the NCI-designated Cancer Centers, and NCI's Community Cancer Centers Program (NCCCP) pilot.
This survivorship research conference has highlighted the gaps in our knowledge base, what it is going to take to address those gaps, and what we need to do to get there. I know we will!
Sparing Patients Treatments They Don't Need
Hippocrates would approve. The early days of personalized medicine are as much about "doing no harm" as about matching patients with the most appropriate therapies.
In cancer, a handful of molecular markers can help guide clinical decisions. For instance, tests can identify candidates for drugs such as imatinib (Gleevec). At the same time, markers are emerging that can identify patients who should not receive a treatment, and as new research suggests, this is valuable information.
"Patients are well served when physicians can forego a particular therapy and avoid the treatment's toxic effects," said Dr. Richard Schilsky of the University of Chicago, who writes about predictive biomarkers in the June Lancet Oncology.
"There really are no highly reliable biomarkers that predict a positive response to a cancer therapy," he continued. "The estrogen receptor for breast cancer is probably the best one going."
The biology of cancer is so complex that biomarker studies are more likely to find, say, a genetic change that causes resistance to a drug than a single biomarker that predicts a positive response.
One such marker of resistance is the gene KRAS in colorectal tumors. Patients with advanced tumors that carry KRAS mutations appear not to benefit from the addition of cetuximab to chemotherapy, as researchers reported this month at the American Society of Clinical Oncology (ASCO) annual meeting.
Patients with these mutations (one-third of those with the disease) should be spared the side effects and cost of cetuximab and a related drug, panitumumab, researchers said at the meeting. In Europe, cetuximab and panitumumab are approved for colorectal cancer only in patients with normal KRAS genes.
The new results, supported by other studies, were a tipping point. Within days, NCI and its Cooperative Group partners stopped enrolling patients on colorectal cancer clinical studies using cetuximab until this new information on KRAS can be appropriately incorporated into the trials.
As new drugs continue to expand treatment options, it will be even more important to know which ones to withhold.
"We are in an exciting era of targeted agents, and there are hundreds more in the pipeline," said Dr. Julie Gralow of the Fred Hutchinson Cancer Research Center at the ASCO meeting. "How are we going to afford these? One answer is that we need to identify patients who are likely to respond and [then] hold the money and hold the toxicity."
A goal for the field is to develop biomarkers in parallel with new drugs, so that the biomarkers can be validated in final-stage clinical trials. Validation and reliable testing is critical, because errors could deprive patients of a valuable treatment or expose them to unnecessary risk.
A decade after the approval of the breast cancer drug trastuzumab (Herceptin), researchers are still exploring the best way to identify candidates for the drug. Dr. Schilsky noted that while the current test is considered a positive predictor, only about 25 percent of advanced HER2-postive tumors respond to the drug. "So, the test may be better at identifying non-responders," he said.
Another biomarker test designed to help patients avoid an unnecessary treatment is Oncotype DX. A clinical trial (TAILORx) is asking whether the genomic test can identify women with ER-positive, early stage breast cancer whose risk of recurrence is sufficiently low that they can safely avoid chemotherapy after surgery.
Beyond what biomarkers can do for individual patients, many researchers believe they could speed the development of new drugs by enrolling patients who are "likely responders" in clinical trials. Fewer patients might then be needed to meet the goal of the study, and this could save money, as well.
Some companies are searching for biomarkers in preclinical studies, but large trials may be needed to find useful markers. The evidence on KRAS and cetuximab, for instance, came from 1,200 patients in many different trials.
Preclinical studies often don't produce biomarker candidates, and "you may only begin to relate a biomarker to efficacy after treating hundreds or thousands of patients," said Dr. Eric K. Rowinsky, the chief medical officer at ImClone Systems, which initially developed cetuximab. The company starts biomarker studies for all of its experimental drugs early in their development, he said.
Many experts believe it is only a matter of time before all patients with colorectal cancer have their tumors tested for KRAS mutations following surgery. It also seems likely that physicians will use combinations of positive and negative predictive markers in the future.
"The KRAS story is tremendous," said Dr. Rowinsky. "We've always known in oncology that most patients won't respond, and we have become accustomed to that. We have kind of shut our eyes to the reasons. This story tells us we should always look for the reasons patients do or do not respond to any therapy."
—Edward R. Winstead
Treatment for Advanced Carcinoid Tumors
Name of the Trial
Principal Investigator
Why This Trial Is Important
Doctors are eager to find new ways to treat advanced carcinoid tumors. One strategy being studied is the inhibition of tumor angiogenesis. Carcinoid tumors tend to produce a lot of blood vessels and may be susceptible to antiangiogenesis therapy.
The monoclonal antibody bevacizumab (Avastin) has been shown to inhibit tumor angiogenesis and is approved by the FDA to treat several different cancer types. In this trial, patients with advanced carcinoid tumors that have spread (metastasized) or that cannot be surgically removed (unresectable) will be randomly assigned to receive the drug octreotide acetate along with either bevacizumab or interferon alfa. The combination of octreotide acetate and interferon alfa is often used for refractory carcinoid syndrome, a collection of symptoms - including flushing, abdominal pain, and diarrhea - caused by hormones secreted by advanced carcinoid tumors.
"In our previous phase II study comparing these combinations, the addition of bevacizumab to octreotide acetate led to rapid and sustained decreases in tumor blood flow, resulting in disease stabilization in most patients and even producing partial responses in some patients," said Dr. Yao. "Additionally, patients receiving bevacizumab were more likely to have stable disease at 18 weeks than patients who received interferon.
"With this phase III trial, we hope to confirm these results and possibly establish bevacizumab as a standard therapy for patients with these difficult to treat tumors."
For More Information
An archive of "Featured Clinical Trial" columns is available at http://www.cancer.gov/clinicaltrials/ft-all-featured-trials.
FDA Warns of Fake Cancer Cures Online
The Internet has provided a mechanism for bogus cancer cures to flourish, according to an FDA press release. Although the products being sold online are not regulated by the FDA, the agency has authority to issue the warnings because the product marketers claim their products "cure, treat, mitigate, or prevent disease" without having undergone testing for safety and effectiveness. Therefore, the agency considers them unapproved new drugs marketed in violation of the Federal Food, Drug, and Cosmetics Act.
"These warning letters are an important step to ensure that consumers do not become the victim of false 'cures' that may cause greater harm to their health," said FDA Associate Commissioner for Regulatory Affairs Margaret Glavin.
More information about the FDA warnings, including a list of the 125 fake cures consumers should avoid, can be found on the FDA Web site.
Following are newly released NCI research funding opportunities:
Pediatric Brain Tumor Consortium
Announcement Number: RFA-CA-08-026
This is a renewal of RFA-CA-04-501 and will use the U01 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3890. Inquiries: Dr. Malcolm Smith - email@example.com.
Millennium Promise Awards:
Announcement Number: PAR-08-175
This funding opportunity will use the D43 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3889. Inquiries: Dr. Aron Primack - email@example.com.
Centers for Innovation in Membrane Protein Production for Structure Determination
Announcement Number: RFA-RM-08-019
This is a renewal of RFA-RM-04-009 and will use the P50 award mechanism. For more information see http://researchportfolio.cancer.gov/initiativedetail.jsp?InitiativeID=3888. Inquiries: Dr. John C. Norvell - email@example.com.
NCAB Hears of Changes to the NIH Roadmap
Dr. Dinah Singer, director of NCI's Division of Cancer Biology, provided a historical overview of the Roadmap mission and vision; the scientific programs that have been funded; and a description of the new "Transformative R01" grants, a 5-year pilot program with funding opportunities to be announced this year.
Six areas of special emphasis for fiscal year 2009 have been identified: new protein-capture technologies, the science of behavior change, functional variation in mitochondrial disease, 3-D tissue models, the transition from acute to chronic pain, and pharmacogenomics.
A videocast of the 2-day meeting can be found at http://videocast.nih.gov/PastEvents.asp.
New HMO Cancer Research Network Booklet Available Online
The CRN provides a framework for leading and working with others to address cancer research challenges in the areas of prevention, early detection, treatment, survivorship, surveillance, and end-of-life care. The CRN is also uniquely positioned to study the quality of cancer care in community-based settings.
The network includes research organizations affiliated with 14 large health care delivery systems covering nearly 11 million individuals and enables access to community-based health care systems data and health informatics, allowing for large, multicenter, multidisciplinary intervention research that addresses the spectrum of cancer control issues.
Abstracts Being Accepted for Cancer Immunology and Immunotherapy Symposium
Sponsored by CCR's Center of Excellence in Immunology, this meeting will host leaders in the field of cancer immunology and immunotherapy, include recent advances in both translational and clinical research, and provide a forum for discussion and debate on promising immunologic approaches to prevent and treat cancer.
Abstracts are being accepted for the poster session. The deadline for submission is July 15. Registration is free, but seating is limited. Online registration and instructions for abstract submission can be found at http://web.ncifcrf.gov/events/CancerImmunology/default.asp.
The full program can be found at http://web.ncifcrf.gov/events/CancerImmunology/program.asp. For conference-related questions, contact Karen Kochersberger at firstname.lastname@example.com or 301-228-4027.
Disparities Summit Scheduled for July 14-16
Summit '08 will share evidence-based prevention, screening, treatment, and survivorship interventions from the Community Networks Program, Minority Institution and Cancer Center Partnerships, and Patient Navigation Research Program.
This year's summit will also showcase scientific efforts in diversifying the cancer health disparities training pipeline and provide grant-writing basics, components to build a successful research career, and a mock review session for the Continuing Umbrella of Research Experiences (CURE) program.
The summit is sponsored by NCI's Center to Reduce Cancer Health Disparities. On-site registration will be available. For more information about this meeting, go to: http://www.cancermeetings.org/CHDSummit08/index.cfm.
Undergrads Try Integrative Science
It's June, the month when college students around the country finish their spring semester and head home to save money from summer jobs, or take summer classes so they can graduate on time. But a select group of 13 has bigger plans.
These students are recipients of Integrative Cancer Biology Program (ICBP) Cancer Research Fellowships, a program in its third year that places sophomores and juniors for 9 weeks in laboratories that study cancer as a complex integrative system, developing mathematical and computational models for diagnosis and treatment of the disease.
"One of the challenges for today's cancer researcher is incorporating large and diverse information about the disease. This increasingly requires multiple expertise and is a fundamental aspect of the ICBP," says Dr. Dan Gallahan, who directs the program and is deputy director in NCI's Division of Cancer Biology. "Through this fellowship, undergraduates are exposed to multiple disciplines addressing real cancer problems."
"The students who we select are exceptionally bright, but they're not sure what a career in research really means," explains Dr. Betty Tarnowski, ICBP education and outreach coordinator. "This program gives them the exposure to determine if research is something they would like to pursue."
Most of the ICBP fellows are biology majors, but many of them study math, engineering, computer science, or physics.
Anastasia Krymkowski, a double major in applied mathematics and computer science at the University of Vermont, with a minor in art, is working this summer with Dr. Thomas Deisboeck, who directs the ICBP Center at Massachusetts General Hospital, and with Dr. Santosh Kesari at the Dana-Farber Cancer Institute. She is using brain cancer stem cells and mathematical analysis to help develop computer models of tumor signaling networks.
"I enjoy thinking spatially, and modeling a virtual tumor seemed like the perfect fit for that," says Ms. Krymkowski, who is still weighing her options after graduation. "I've always known that were I to pursue a career in a medical field, I'd want to study something that has a devastating impact on people, so I'm definitely satisfied to be working on this project."
Arthur Edwards, another ICBP fellow who is studying bioengineering at the University of South Florida, is being mentored by Dr. Paul Spellman at the Lawrence Berkeley National Laboratory. Most of his friends are taking it easy at the beach this summer, he says, while he's using Bayesian models to look at gene expression, gene copies, and methylation patterns in breast cancer.
"I'll be asking a lot of questions, since I don't really have too much training in this field," he says. His career plans include graduate school, but he's not sure yet what area of research will be his focus. "After this summer I'll have a better idea."
Students have much to gain from these fellowships: the chance to try their hands at cancer research with some of the nation's top scientists as mentors, as well as earn a stipend and explore a different city. But they're not the only ones who benefit from the arrangement.
"These eager students bring a refreshing new perspective to our challenging projects," says Dr. Deisboeck, whose mentoring last summer encouraged Christina Birch to begin graduate school this fall studying biological engineering at MIT, which hosts an ICBP Center, so that she can continue the integrative approach to research.
"We are delighted to contribute to the next wave of students who are trained in both the quantitative and quality aspects of cancer research," he says. "They are who this field needs desperately in order to move ahead."
—Brittany Moya del Pino


text:
Microsoft Certifications
New & Notable
Microsoft Certifications News
January 24, 2014
New Microsoft certs changes that IT pros need to know
The Windows Server 2012 R2, Windows 8.1 and System Center 2012 R2 releases are responsible for the updated MCSA and MCSE cert exams.
April 11, 2012
Microsoft revamps IT certifications for cloud, requires recertification
Get ready to recertify: Microsoft detailed changes to its certification platform, with a focus on the cloud.
November 16, 2009
Setting a career path via Windows 7 certification
The general state of the economy has increased interest in IT certification training across the board.
June 10, 2008
Microsoft updates IT on key product releases
The software company has new beta releases for SQL Server 2008, ILM and a handful of new topic-specific certifications in the pipeline.
Microsoft Certifications Get Started
Bring yourself up to speed with our introductory content
Microsoft Certified Educator improves education and technology ties
This new certification teaches educators how to effectively use the link between learning and Microsoft technology in the classroom. Continue Reading
Microsoft Second Shot gives IT pros free retake of certification exams
The latest Second Shot promotion lets admins retake certain certification exams for free. But the offer only lasts until May 2014. Continue Reading
Microsoft certification exam strategies for different testing formats
In this excerpt from MCSA/MCSE 70-290 Exam Cram by Dan Balter and Patrick Regan, learn about testing strategies that can help raise your Microsoft certification exam scores. Continue Reading
Evaluate Microsoft Certifications Vendors & Products
Weigh the pros and cons of technologies, products and projects you are considering.
What the latest Microsoft Learning program changes mean for IT pros
A revamped design for the MS Learning site gives IT pros a look at some potential changes coming to certs -- new and old. Continue Reading
Should I focus on MOS certification if I wish to teach computer applications?
Expert Ed Tittel discusses Microsoft Office Specialist (MOS) certification training and what can be gained from it. Continue Reading
New tools, APIs spell update for developer credentials
A little research and thinking convinces me that for both the MCAD and the MCSD credentials, changes are in the offing some time next year. Read why here. Continue Reading
Manage Microsoft Certifications
Learn to apply best practices and optimize your operations.
Microsoft Learning certification needs a revamp
One year after Microsoft Learning canceled two top-tier certification programs, Exchange MVPs discuss what it means for IT pros and how industry certs compare. Continue Reading
Microsoft certification changes coming with updated software releases
Here's what you should know about impending Microsoft certification changes after the Windows Server 2012 R2 and Windows 8.1 GA date announcement. Continue Reading
Five MCSA training tips IT pros should read to prep for certification
With MCSA one of the most popular Microsoft certifications to pursue, we compiled the five best tips to help admins with their MCSA training. Continue Reading
Problem Solve Microsoft Certifications Issues
We've gathered up expert advice and tips from professionals like you so that the answers you need are always available.
Combining certifications and college degrees on the IT career path
A college degree or certification -- which is better? Each has its own merits, but having both can put you on a successful IT career path. Continue Reading
How to advance your cloud skills and get ahead of the gap
There may be a growing shortage of IT pros with cloud skills, but you can take action now and become a valuable asset with the right skills. Continue Reading
You can study for MCSA: Windows Server 2012, but not Windows 8 -- yet
Because of the seven week gap between GA dates, there are more materials available for MCSA: Windows Server 2012 than Windows 8. But that will change. Continue Reading

subset: commoncrawl


text:
This weekend in Wallace the streets of downtown were sounding a little blue. That's because the 2nd Annual Historic Wallace Blues Festival was in full swing.
KHQ sent one of our photographers, Reed Schmitt, to Wallace to check it out and not only did he get to hear some amazing music, but he took some cool pictures too! Check them out!


text:
cmCreatePageviewTag( sfcm_makePageId( 'Info', true ), sfcm_makeCategoryId( '548479' ), '', '', '10052-_-Info-_--_--_--_--_-'+ (_sfcm_isVIP ? 'Y' : 'N') +'-_-');
Beer lovers rejoice, you can now enjoy your favourite tipple with cheeses and bread with Greta blond ale spreadable beer. An ingenious collaboration between an Italian chocolate maker and an Italian beer brewer, the result is a sweet and beer-perfumed jelly with a delicate blond ale flavour. The beer spread makes a unique accompaniment for hors d'oeuvres and cheeses, or try spread on toast or even as a stuffing or garnish for tarts and cakes.
cmCreatePageviewTag( sfcm_makePageId( 'Details', true ), sfcm_makeCategoryId( '' ), '', '', '10052-_-Details-_--_--_--_--_-'+ (_sfcm_isVIP ? 'Y' : 'N') +'-_-');
UK icon UK delivery
Standard £4.95
Nominated or next day From £8.00
Same day (order by 4pm for delivery within M25) £16.00
Click & Collect icon Click & Collect
We'll deliver this product to your nearest store Complimentary
International icon International delivery
Delivery within Europe £15.00
Delivery to the rest of the world £25.00
Returns icon Returns
It's okay if you change your mind, we offer a 14 day returns policy.


text:
Here is my 2 in the viewing gallery. Now to try and upload the .png files.
I uploaded my 2 .png files without any problems (I hope)
Last edited by glonet; 04-29-2009 at 03:11 PM. Reason: addition
Ok - getting caught up with things over here. Count me in! I'm so glad that there's another challenge that didn't end on April 30th. I like them staggered a little. I'll be back with some layouts within 4 days. If not tonight, it'll have to be Mon or Tues night. Can't wait, though!!
I would love to sign up.. Hugs Kay
Happy to have you, Kay! I'll add you to our list. Can't wait to see your pages!
love this kit - I hope to have time to join in on this one - the kit is fantastic!
We do not stop playing because we grow old...We grow old because we stop playing.
Lovely kit. I'll do this challenge.
I am working on this. I'm having a bit of trouble punching out the hole for the photo in PSE 3.0. I tried the magic wand after I had saved the page as a .jpg. But the wand selected some of the other white areas. I tried erasing, but that was very complicated because of the objects that are in front of the photo space I need to erase. Any hints? Heeeellllp!


text:
Call Us At 1.800.377.0617
Argosy University Online Programs builds on our heritage of academic excellence and individual attention in a format that can fit your busy lifestyle.
It's not too late to get started. Classes begin October 27th.
Argosy University offers a variety of degree programs in flexible learning formats including blended or campus learning.
Argosy University Programs
Related Links
College of Education
Teaching and Learning
Program Information | Admissions Requirements | Course List
The Doctor of Education (EdD) in Teaching and Learning degree program at Argosy University, Hawai'i is designed to prepare educators as change agents and leaders in the P-12 setting who engage actively in their communities, using appropriate pedagogy and technology to foster the development of global citizens.
This degree program is also offered at other Argosy University Locations
Only the MAED in Educational Administration, the EdS in Initial Educational Administration, and the EdD in Initial Educational Administration programs offered through Argosy University, Hawaii College of Education meet all California Tier 1 Principal Licensure requirements. Upon program completion and the passage of all required California state exams, students are eligible to apply for California Tier 1 Principal licensure.
This program DOES NOT lead to teacher or administrator certification, licensure, or endorsement in any state in the United States. These programs are designed to enhance the skills and knowledge of students who are already certified, licensed or endorsed and for students who are interested in pursuing these degrees for reasons other than obtaining teacher or administrator certification, licensure, or endorsement. Additionally, the credits earned through participating in these programs offered by Argosy University are unlikely to be transferable to any other similar program that is approved for teacher or administrator certification, licensure or endorsement in any State.
Any other program offered through Argosy University, Hawaii College of Education DO NOT lead to teacher or administrator certification, licensure, or endorsement in any State in theUnited States.
The programs offered through Argosy University, Online Programs DO NOT lead to teacher or administrator certification, licensure, or endorsement in any State in the United States regardless of the State in which the student resides.
All fields required
Step 1 of 2


text:
Party Supplies
Cheap Prom Favors
Personalized Prom Candy
Personalized Chocolate Lollipops
Under the Sea Ocean Floor Personalized Milk Chocolate Lollipops
Design: RC264
Under the Sea Ocean Floor Personalized Milk Chocolate Lollipops
Personalized Milk Chocolate Lollipop
Made to Order - 1 business day processing+shipping
That's an item we create especially for you. When you place an order, please allow for the stated production time. Unfortunately, we are not able to rush our production times or ship dates. Even if you choose not to personalize the item, production times remain the same.
Your Price: $1.99 each
Minimum Order Quantity: 36
Qty. of 36 - 71 price $1.99 each
Qty. of 72 - 143 price $1.79 each
Qty. of 144 - 287 price $1.69 each
Qty. of 288 - 431 price $1.59 each
Qty. of 432 + price $1.49 each
Personalize »
More Details
WARNING: FOOD ALLERGY: Made in a facility that uses peanuts, nuts and coconut.
Dare to Compare!
As low as $1.49 each!
Delicious milk chocolate flavor!
Choose the design that fits your style, upload your photo or logo, select your font color and style, and add your text!
The most up-to-date styles and designs available anywhere online!
The more you buy, the more you save!
Personalized Chocolate Lollipops
2.5 ounces of chocolate.
Each chocolate lollipop measures 3 inches in diameter x 7 1/2 inches long.
Assembly required.
Candy Bar Ordering Instructions
We want your chocolate to arrive in the best condition. We only ship our chocolate on Monday, Tuesday or Wednesday.
Please provide a ship-to address where someone will be able to care for your chocolate immediately upon arrival. If you will not be home, possibly your workplace, a friend or neighbor.
When necessary, we will use insulated cooler packaging at no additional cost to you.
When purchasing candy bar wrappers we recommend using our permanent adhesive tape or some other kind of two-sided tape for easy assembly.
Nutrition Facts
Serving Size 1.2 oz (34g)
Servings Per Container 2
Amount Per Serving
Calories 180 Calories from Fat 100
% Daily Value*
Total Fat 11g 17%
Saturated Fat 6g 32%
Trans Fat 0g
Cholesterol 5mg 2%
Sodium 25mg 1%
Total Carbohydrate 20g 7%
Dietary Fiber less than 1g 3%
Sugars 19g
Protein 2g
Vitamin A 2% • Vitamin C 0%
Calcium 6% • Iron 2%
*Percent Daily Values are based on a 2,000
calorie diet. Your daily values may be higher
or lower depending on your calorie needs:
Calories: 2,000 2,500
Total Fat Less than 65g 80g
Saturated Fat Less than 20g 25g
Cholesterol Less than 300mg 300mg
Sodium Less than 2,400mg 2,400mg
Total Carbohydrate 300g 375g
Dietary Fiber 25g 30g
Calories per gram:
Fat 9 • Carbohydrate 4 • Protein 4
Milk Chocolate (Sugar, Cocoa Butter, Milk, Chocolate Liquor, Soy lecithin, and Vanilla).
Recommended Items
Top Picks
Product Reviews
Questions & Answers
Recommended Products
People who viewed "Under the Sea Ocean Floor Personalized Milk Chocolate Lollipops" also viewed
My Account
Sign In to Your Account
Forget your password?
Not a Member Yet?
Track My Order
Customer Service
Prom Favors
8 Ways to Make Your Prom More Affordable
After-Prom Dos and Don'ts
Get in Shape for Prom in 60 Days
Prom Dress Charities Share the Glamour
Prom Mistakes and How to Avoid
Prom Skin Care & Make Up Tips
Prom Tips for Parents
Top 10 Prom Movie Scenes
Which Prom Dress Is Right For You?
Prom Dress Marketplace
Prom Jewelry Marketplace
Prom Makeup Marketplace
Prom Shoes Marketplace
American Prom
American Prom Coupons
American Prom Rewards
About Us
Prom Central
Prom Ideas
Prom News
Online Catalog
Customer Care
Order Status
Retrieve a Quote
Contact Us
Privacy Statement
Contact Us
Site Map
American Prom Blog
Product Safety
Canadian Orders
Copyright © 2014 American Prom


text:
- 866-699-7367
- Customer Service
- My Account
- Store Locator
Triton Three-Eye
Named after the messenger of the sea, the Triton Three-Eye communicates true nautical style. Available in premium full grain leather, its leather quarter lining and fabric vamp lining provide sockless comfort. Flexible Strobel constuction is coupled with smart details, like a padded tongue, functional lacing, and corrosive-resistant Sebago® eyelets. Comfort features include a nylon shank for support, as well as a lightweight EVA midsole. Sebago® Triton™ rubber cups sole provides non-marking slip resistance.
- Flexible Strobel Construction
- Premium Full Grain Leather
- Leather Quarter Lining and Fabric Vamp Lining
- Padded Tongue
- Functional Lacing System
- Corrosive-resistant Sebago® Eyelets
- Nylon Shank
- Removable, Anatomical Sebago® Footbed
- Lightweight EVA Midsole
- Sebago® Triton™ Non-marking, Slip-resistant Rubber Cup Sole
Overall Rating
This is my third pair. Most comfortable shoe I ever wore. I wish the Schooner had the same lining and shape.
Product Size Rating:Sized as Expected
Great shoe
It took a couple of tries to get the right size, since they are large, but once I got it right what a shoe! Very comfortable, fits like a glove and great support. Plus removable insole so you can wash it. I use it all around, boating, grocery etc. Looks better than the picture.
We appreciate the updated review. We are thrilled you were able to wash the removable footbeds so they are looking and smelling like new. Also, thank you for your helpful tip on sizing and the true color of the Triton Three-Eye.
Product Size Rating:Larger than Expected
How do you most use this product?:All around shoe
i so this shoes at the mall. at first didnt like the look much. my wife said they were really ugly but when i traid than i realize that they were the most comfortable shoes i ever tried in my life. they are very comfortable shoes. the best
We are so glad you found a style that is super comfortable for you. Hopefully its look as grown on you!
Product Size Rating:Sized as Expected


text:
Monday, 26 Apr 2010 08:01 AM
© Copyright 2014 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
Friday, 04 Jan 2013 13:06 PM
Tens of thousands of Fatah supporters rallied in the Hamas stronghold of Gaza on Friday for the first time since they we . . .
Tuesday, 17 Jul 2012 18:11 PM
. . .
Friday, 13 Jul 2012 12:27 PM
So will Obama be known in history as the man responsible for World War 3?
Poor old Democrats; shaking in their boots over the midterm elections. Just...
This has to be the funniest story I've seen in a while!!!!!! First, the King...
Obama will ask for $5 billion from Congress, but a good chunk of that will...
And still Catholics vote for Democrats. Dem imposed taxes pay for abortions....
Newsmax, Moneynews, and Independent. American. are registered trademarks of Newsmax Media, Inc. Newsmax TV, NewsmaxWorld, NewsmaxHealth, are trademarks of Newsmax Media, Inc.


text:
Today, I have two movies. They're offered together as one rental from Netflix. Gems from the early 60s, both "capitalizing on our fears of apocalyptic destruction." Each reminds me quite a bit of one of my very FAVORITE films, Night of the Living Dead.
Panic in Year Zero! (1962)
A family on a fishing trip learns that nuclear war has broken out, and tries to hide deep in the woods or a cave.
Who would have thought a film so campy as to include an exclamation point in its title would be this compelling? Ray Milland plays your average 1950s-style family man with a plan to take the wife and kids on a trip to the mountains. They've got one of them fancy newfangled camper-trailer deals hooked up to the family roadster and everything!
Well, not long after the crew gets out of Los Angeles, the Big One hits. Yeah -- a full-blown nuclear war. They see mushroom clouds on the horizon and know its time to really shove off. As general chaos descends on the country, our heroes rob a hardware store, shoot a few people, and set up a little camp in a remote cave as they wait for law and order to return.
What an excellent movie. For the full 90 minutes, I was waiting for some disappointing, ironic revelation to come -- like, say, that there wasn't really a nuclear war taking place, and all of this panic was for nothing. You know, that kind of thing. It's what usually happens in these sorts of movies. But, no; not this time. Instead, the Big One really HAS come, and people have started to act like animals. Mr. Baldwin must get his family across a panic-stricken California to safety. I really liked this guy. He's the old-fashioned, Take Charge kind of American family man. Maybe some of his decisions are wrong, but by God, at least he makes them.
Of course, Baldwin's behavior raises a variety of moral questions. He rationalizes setting fire to another traveler's car, punching out a gas station attendant, and shoving a gun in a store owner's face on the grounds that HIS kind of people will be needed to rebuild the world "when civility returns to civilization". Isn't he just another part of the problem, even if well-meaning?
In the end, Baldwin DOES get his family through the nightmare, and he DOES help some others along the way. Frankie Avalon plays the teenage son eager to do right, despite nearly getting a lust for blood after shooting a marauding beatnik at one point. It was interesting to see that side of him. I also loved the snappy, retro dialogue and kitschy jazz score. The only downside to Panic in Year Zero! is that I probably wouldn't want to watch it again. Panic is the kind of movie that would probably drag a bit on a second or third viewing. Still, I recommend this film highly.
4 out of 5.
The Last Man On Earth (1964)
A scientist is the last person left alive after a horrible virus outbreak. Everyone else has turned into zombie/vampire-like creatures. They torment the main character while he cowers in his home at night, while he hunts and kills them during the day.
The Last Man on Earth is classic Vincent Price in all his weird, dark glory. Price plays Doctor Robert Morgan, a guy who is apparently the only survivor of a pandemic that has turned the rest of the world's population into vampires. Each day, he carries out the same routine of picking up supplies, searching for vampire nests, and burning the bodies of undead that he finds lying in the streets. At night, he barricades himself in a house while ghouls surround the building and taunt him. We're also given information on how this whole situation unfolded through multiple flashbacks.
A horror movie quite like this would never be made today. In fact, they TRIED just a few years ago, with Will Smith's crummy remake of The Last Man on Earth, called I Am Legend (both, incidentally, are based off the same book). Part of the reason why the more recent version wasn't as effective, I suspect, was that it didn't star Vincent Price, who puts his creepy, tortured stamp on every frame of the 1964 film. While I usually look down on voice-overs as a narrative device, in the case of Last Man on Earth, I'll make an exception, since the VOs are provided by Price.
Price's descriptions of the grim tasks Doctor Morgan must carry out each day, along with long scenes of him stalking the streets of a totally empty city, make for a truly eerie experience. And the nighttime vampire attacks are effective in a simmering sort of way that today's horror filmmakers don't seem to understand (the vamps in this movie actually act a lot like Romero's zombies in Night of the Living Dead). Eventually, Doctor Morgan meets a woman who has also apparently survived the outbreak (or, HAS SHE?), and things get a little convoluted from that point on. Regardless, The Last Man on Earth is undoubtedly a horror classic worth checking out. Considering that it can be rented along with Panic in Year Zero! from Netflix for the price of one, there's no reason not to see this picture. Enjoy!
3 out of 5.


text:
PORTAGE (WKZO) -- EPIC Crew, a local running group, held an event on Tuesday evening to show their support for victims of the Boston Marathon bombings.
Brett Beier, representative from EPIC Crew, said the run was intended to show the sympathy local area runners have for those hurt in Boston. Watch above for an interview from Beier.
Hundreds turned out for the event, read more here.
VIDEO: Solidarity Run a chance for Kalamazoo to rise together


text:
Detroit ditto heads rejoice. Your leader is interested in news in Detroit, at least enough to qualify a report on a large Powerball jackpot as more proof that 'low-information outreach' is working. The national conservative radio host on the Excellent in Broadcasting (EIB) network refers to a report by Fox 2's Roop Raj in this way: "Our outreach to the low-information voters is showing signs of success." (More information on how Limbaugh defines a 'low-information voter' is posted further down in this article.)On Wednesday, during a report on Wednesday's Fox 2 News Morning show, Raj made reference to Limbaugh as a way to help viewers relate to wining a large sum of money if they should happen to win the Powerball drawing. (Play the video in the player to hear it.)HERE IS WHAT RAJ SAID: It's one of the largest jackpots in the history. If you took the cash option, it would be 292 million, a lot of money. But you spread that over the course of maybe 30 years, and it ends up being 12 million a year. Reed Hastings, the CEO of Netflix, he actually makes $300 million a year. Rush Limbaugh, the talk show host, his net worth is $350 million a year. And so he actually makes closer to, you know, $30 million a year. So, you know, these are just some comparison, some numbers out there for you to think about.After hearing Raj's clip, Limbaugh posted an article on his web site wondering why of all the people Raj could have used to relate to the size of the drawing, why did he choose him? Not Brad Pitt. Not Snoop Lion (formerly Snoop Dog). Limbaugh surmises that Raj picked him because 'low information outreach' is a success.So what are 'low-information voters?' ACCORDING TO A MARCH 25TH POST ON LIMBAUGH'S WEB SITE, 'LOW INFORMATION VOTERS' ARE DEFINED AS THE FOLLOWING: Prisoners to the media, which has dumbed them down. Low-information voters can be doctors. Low-information voters can be scientists. They can be among all walks of life. It has nothing to do with IQ. It has to do with what they don't know because of their media sources. Low-information voters are clearly people that don't have all the information available to make a voting choice. That's all they are. And they're all over the place. And most of them do vote Democrat.An e-mail was sent to Limbaugh requesting further clarification of on the term 'low-information voter.' We'll post his response if it is received.Why did Roop Raj pick Limbaugh as a way to relate to winning a large Powerball jackpot? RAJ: I've done dozens of stories on large lottery jackpots over the years. This time the jackpot is worth more than $300 million, so I 'Googled' people "who are worth' more than $300-million. The CEO of Netflix, Reed Hastings, was on the list, along with several baseball players and Rush Limbaugh. The easy reference is always baseball players, so I went with Hastings and Limbaugh. I just thought it was interesting. It's a fun story Rush, relax."
KDFW FOX 4400 N. Griffin StreetDallas, Texas 75202
Main Station Directory:(214) 720-4444News Fax:(214) 720-3263 or (214) 720-3333


text:
Raw Lavender Honey has some unique properties that set it apart as a gourmet varietal honey.
Lavender Honey ranges from very light to mid dark depending on the time of year it was harvested. Our Lavender Honey comes from a lavender farm in Mona, UT. We take great pride in our raw lavender honey because of the many inherenthealth benefits of lavender. Our lavender honey is not infused or blended with anything else. It is as pure as the day the bees produced it.
Sort By:
Raw Lavender Honey - Pint (1lb 6oz)
Showing 1 to 2 of 2 (1 Pages)


text:
Jon Huntsman Jr.
Douglas C. Pizac/Associated Press
News about Jon Huntsman Jr., including commentary and archival articles published in The New York Times.
Featured Articles
Envoy to China to Resign, Weighing '12 G.O.P. Bid
The United States ambassador to China, Jon M. Huntsman Jr., intends to leave his position on April 30, clearing the way for him to explore a potential 2012 Republican presidential bid.February 1, 2011 usNews
Utah Governor Chosen as Ambassador to China
President Obama has scored a political coup in attracting Gov. Jon Huntsman Jr., who had been considered a possible presidential contender in 2012.May 17, 2009 worldNews
One Mother, 7 Dead Newborns and a Stunned Community in Utah
The tale of a profoundly troubled woman and her dead children has again cast a national glare on the most intimate and inexplicable kind of crime.
April 27, 2014, Sunday
MORE ON JON M. HUNTSMAN JR. AND: Child Abuse and Neglect , Huntsman, Megan , Pleasant Grove (Utah) , Murders and Attempted Murders , West, Darren Brad
Lives of the After-Party
The drugs and alcohol may not be as free-flowing, but the cast of "Saturday Night Live" continues to star in one of the longest-running soirees in the city.
February 2, 2014, Sunday
MORE ON JON M. HUNTSMAN JR. AND: Saturday Night Live (TV Program) , Michaels, Lorne , Parties (Social) , Television
Peter Lynch Once Managed Money. Now He Gives It Away.
A look at how Mr. Lynch and his wife handle their substantial philanthropy in an attempt to divine lessons for the rest of us.
November 9, 2013, Saturday
MORE ON JON M. HUNTSMAN JR. AND: Asset Allocation (Personal Finances) , Philanthropy , Lynch, Peter , High Net Worth Individuals
Jon Huntsman Sr.'s Early Calling to Philanthropy
The billionaire businessman is among the few people who have given away more than $1 billion. His focus is on cancer research, but he has supported many causes.
November 2, 2013, Saturday
MORE ON JON M. HUNTSMAN JR. AND: High Net Worth Individuals , Philanthropy , Huntsman, Jon M Sr , Huntsman Cancer Institute
Book Details Obama Aides' Talks About Replacing Biden on 2012 Ticket
Aides concluded that despite Hillary Rodham Clinton's popularity, the move would not offer a significant enough boost to President Obama, according to the book, "Double Down."
November 1, 2013, Friday
MORE ON JON M. HUNTSMAN JR. AND: Books and Literature , Heilemann, John , Clinton, Hillary Rodham , Biden, Joseph R Jr , Halperin, Mark , Presidential Election of 2012 , Vice Presidents and Vice Presidency (US) , Obama, Barack
10 Questions for Jon Huntsman
The former Republican presidential candidate and ambassador to China spoke with John Harwood about the United States-China meeting, the future of the Republican Party and the 2016 presidential race.
June 7, 2013, Friday
MORE ON JON M. HUNTSMAN JR. AND: Xi Jinping , China , United States , Republican Party , Computers and the Internet , International Trade and World Market , Presidential Election of 2016
As Chinese Leader's Visit Nears, U.S. Is Urged to Allow Counterattacks on Hackers
As President Obama prepares to meet with President Xi Jinping of China, a commission is recommending steps that could raise the cost of the theft of American industrial secrets.
May 22, 2013, Wednesday
MORE ON JON M. HUNTSMAN JR. AND: United States , China , Obama, Barack , Cyberwarfare , Xi Jinping , Chinese People's Liberation Army , United States International Relations , Huntsman, Jon M Jr , Blair, Dennis C
Filling a Fed Vacuum in Bank Supervision
The Federal Reserve must stop its internal wrangling and impose more effective control over the biggest banks, and Sheila Bair is the kind of strong regulator to lead the effort.
March 7, 2013, Thursday
MORE ON JON M. HUNTSMAN JR. AND: Bair, Sheila C , Federal Reserve System , Regulation and Deregulation of Industry , Dodd-Frank Wall Street Reform and Consumer Protection Act (2010) , Banking and Financial Institutions
Republicans Sign Brief in Support of Gay Marriage
Dozens of prominent Republicans signed an amicus brief that will be submitted to the Supreme Court ahead of arguments in two cases next month.
February 26, 2013, Tuesday
MORE ON JON M. HUNTSMAN JR. AND: Same-Sex Marriage, Civil Unions and Domestic Partnerships , Supreme Court , Defense of Marriage Act (1996) , Republican Party , United States Politics and Government , Republican National Committee , States (US) , Boehner, John A
Group From Congress Asks, Why Does America Hate Us? (Answer: See Congress)
About a dozen members of Congress gathered in a Manhattan hotel as part of an effort by No Labels, a bipartisan citizens' group, to find ways to make Washington more effective and even civil.
January 15, 2013, Tuesday
MORE ON JON M. HUNTSMAN JR. AND: United States Politics and Government , House of Representatives , No Labels , Manhattan (NYC) , United States
The Republican Presidential Field
A look at the Republicans who are seeking their party's presidential nomination.
Rss Feeds On Jon Huntsman Jr.
Subscribe to an RSS feed on this topic. What is RSS?


text:
Steve Gorman Sports! 2:00 PM - 5:00 PM
On Air Now.
On Air Now.
A view of sports that goes beyond scores and statistics to the things that make us laugh, cry, think or just want to throw things at the TV.All Posts »
All of the latest news about the Green Bay Packers.
Golf tips & how-tos and equipment reviews. We'll also keep you up to date on the pro golf tour.


text:
X-Hose Pro®
Reversible Bedspread
Singing Bird Clock & Thermometer
Set/2 Drawer Dividers
RFID Armored Wallets
Hot Air Balloon Spinner
Ribbon Braid Hat
Magnetic Board
No Video
These tiered shelves expand to fit any space! Their design gives you a full view of all your cans, spices and whatever else is hiding in your cupboards. Ideal for organizing kitchen cabinets, pantries and bathroom closets. Heavy-duty polystyrene won't sag or dent. Medium 3-tier is 4"H x 7¾"D, expands 14"-26". Large 3-tier is 6"H x 11½"D, expands from 14"-27".
Follow Fresh Finds!
Copyright 2014. Fresh Finds, LLC /
All Rights Reserved. Privacy Policy
Message from Fresh Finds
Fresh Finds
We are now accepting PayPal as a form of payment. For those of you unfamiliar
with PayPal, it is a Web-based service that enables you to pay an online
merchant without revealing your financial information. We've added this payment
option to better meet your expressed needs for confidence, control, convenience
and choice in your payment methods.
Learn more
about PayPal and decide if you would like to set up a PayPal account.
Thanks for visiting our Web site - come back soon!
Close Window


text:
Stating At $110.00
Mini Split HVAC
Super Blowout
WhisperCeiling fans feature a totally enclosed condenser motor and a large blower wheel to quietly move air. A small wheel turning very fast will create more noise than a large wheel turning more slowly for a given airflow. Our fan uses a wide blower wheel that moves a large amount of air at reduced RPMs, so it is quiet enough that you might not even know it's on.
This fan is designed to give you continuous, trouble-free operation for many years thanks in part to its high-quality components and permanently lubricated motors which wear at a slower pace. Also, since heat is always detrimental to motor life (the cooler the environment, the longer the motor will last), we designed the electrical configuration of this model's condenser motor to allow it to operate at lower temperatures, increasing the life of the motor and bearings. And, the fan housing is made of heavy-gauge zinc galvanized steel and painted to protect it from rust.


text:
Toaster oven pizza. This was on a homemade whole wheat cruts with lots of veggies, homemade sauce and some cheddar style "cheez".
Hopefully, I'll be able to post pics of all the food, but I have to get permission first.
wow... what a post! it seems like you've been busy cooking :)ReplyDelete
DROOL-fest, as always, Mel. I really love the 'cheddar-y" soup the best. Your photos are always practically scratch and sniff.
This post reminds me I need to raid my freezer [and my pantry, too].
Beautiful food as usual! Love the soup, it looks so smooth and creamy! And the raosted cherry tomatoes look divine!ReplyDelete
I love my freezer, too--it feels great to pull out a home-cooked meal on a busy night!
As for the pressure cooker, I'm beginning to think I ought to get one. Most everyone seems to love theirs, but... I'm nervous something bad will happen! They sound like they could be dangerous. Do you feel like they're perfectly safe?
I think pressure cookers used to explode and do all sorts of scary things. I was intimidated too by the thought of one, but the new ones have a lot of safety features and are perfectly safe.
Here is the link to the one I have:
Wow, Mel, all the food looks fabulous! My freezer never treats me this well! Best of luck with the party - hope they let you share some photos with us! :)ReplyDelete
Wow - everything looks great but I'm intrigued by the spinach pesto. Pesto is one of my fave foods but I've never tried anything but basil. That brussel sprout soup looks pretty inviting too....and the pizza...it all looks good, as always.ReplyDelete
Mmm it all looks great!ReplyDelete
Mel, your dishes are always spectacular; and hey, that wrap looks gorgeous to me!! I too love using ingredients that are in my freezer, begging to be used in a completely different way than it was used previously (if that makes sense, haha). I look forward to seeing more food photos, if permission is granted! :0)ReplyDelete
My freezer has good stuff in it, but not like that. Holy vegan cannoli!
The ribs and the white bean soup are my favorites I think.
Ah, pressure cooker...on my list of items I want to buy.
My freezer is jam packed with food. I told myself a while back I wouldn't make anything if it didn't involve using up something already in the pantry. Well, that led to a very full freezer! It's hard getting through so much food when it's just the 2 of us.
I noticed your new masthead! Way to go Melody. I really hope that your restaurant materializes. You are such a wonderful chef. I know you would do well.
I've got your teriyaki tempeh marinating in my fridge right now. I was going to cook them for dinner but I forgot I had leftovers so I decided to let the tempeh marinate overnight and cook tomorrow. I'll let you know how it turns out.
wow. that's amazing. see...i wish i knew what half that stuff WAS, let alone if i like it or not. lol i have such a hard time branching out with what i cook because i don't know what ANYTHING tastes like and i hate wasting tons of food to cook this huge meal and none of us like it.ReplyDelete
Yep, freezers are fabulous. I love the roasted fennel and tomato dish....ReplyDelete
Holy cooking! Can I come live at your house! Absolutely amazing!ReplyDelete
Hi! I'm just dropping by to let you know about a food blogging event I'm hosting, called "A Vegetarian Feast." The first round is thanksgiving themed, but broadly it can include any vegetarian dishes that use fall ingredients or make you think of Thanksgiving. If you're interested in participating or mentioning the event on your blog, you can find details here. Thanks!ReplyDelete
That pizza is amazing! I was thinking I might make the chickpea noodle soup from Veganomican tonight but now I'm not so sure. My pizza would have FYH "cheese" too, I don't know how to make good "cheese" for pizza.
I love roasted brussels too, but I tried fresh for the first time and DF said he liked the frozen ones better! I think I might have undercooked them? Who knows...
Another beautiful post :x


text:
Wisconsin Governor Scott Walker has signed a bill making making a crossbow hunting season available to Wisconsin residents. The crossbow season will coincide with the regular whitetail archery season that runs from mid September to November before the gun season gets underway. Crossbow season will also be available for smaller game including rabbits, coyotes, etc.
Prior to the bill, crossbow hunting was only available to residents over the age of 65 and those with disabilities.
Some opposition has been brought forward from traditional bow and arrow hunters thinking that it will change the atmosphere in the woods.
Governor Walker signed the bill on Tuesday .
Photo Credit: http://www.ForestWander.com [CC-BY-SA-3.0-us (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en)], via Wikimedia Commons


text:
If you don't have money or time to go to a Yoga studio. You can find a ton of videos on YouTube. One of my favorite videos and trainers is Jillian Michaels.
Here is her Yoga Meltdown Video:
This is a great workout! It reminds me of my yoga class at Midwest Power Yoga! But like I said before, I can't always make it to my class. This way I can practice my Yoga and stay fit.


text:
Centrally Located Green & Quiet
Jerusalem, Israel Vacation Rentals
Centrally Located In the charming & historical area of Musrara. A short walk to the Old City & Jerusalem center. Three independent units, fully equipped, with a shared courtyard & garden. Suitable for families, friends & solo travelers....
Starting at 60 Per Night/Room
Sunshine Suites--2BR-2BR-Sleep6-Free Parking-WiFi
Tel Aviv, Israel Vacation Rentals
4 apartments (75m²) of 2 bedrooms. Sleeps 6. Free Parking. Free WiFi. 1 minute walk to Tel-Aviv beach. Central Tel-Aviv city. Balcony (8m²) with side sea view. New building (from 2010) + Elevator....
$875 Per Week
Israel Vacation Homes
Aba Hillel, Israel Vacation Rentals
Fully furnished, one and two bedroom duplex apartments. Our luxury apartments are located in Hertzlia, in a 24 hour doorman building just one minute walk from the beach. Contact us for additional rates today!...
Starting at $215 Per Night
Caesarea, Israel Vacation Rentals
Vacation suite apartment at Neot-Golf resort, Caesarea, Israel. Perfect family holiday ,free use of sauna, swimming pool, fitness room, squash, tennis, mini-golf. Also nearby beach, golf, horse riding, spa....
$675 Per Week
Stylish Vacation Apartments in Jerusalem
Jerusalem, Israel Vacation Rentals
Stylish, serviced vacation apartments in the fashionable German colony. Facilities include: equipped kitchen, A/C, Cable TV, DVD, washing machine, free wireless internet, safe, fresh linen and towels. Managed by owner, no agents fee,friendly service...
Starting at $910 Per Week
Stella- Maris Hosting: Vacation Rental
Mediterranean Coast, Israel Vacation Rentals
This short term accomodation apartment , situated on ground floor at the top of a green slope of .Mount Carmel. This apartment is located between walk distance attractions: the Carmelite Church and it's amazing veiws and the Bahai Garde & Temple....
Starting at $65 Per Night
Spacious 2.5BR apt for Passover in Tel Aviv
Mediterranean Coast, Israel Vacation Rentals
Beautiful vacation apt 22 March - 6 April on Ben Yehuda, 2 min walk to beach. Large bedroom with double bed , living room with 3 seater sofa (can be used as a bed) Fully equipped, with washing machine and espresso maker, close to bars and restaurants...
100 Per Night
Jordan valley Vacation Apartment
Tiberias, Israel Vacation Rentals
A beautiful apartment suitable for families or a few couples. Two sleeping rooms, an ample living room and a large private yard with B.B.Q facilities. All new refurbished apartment With new LED TV with Cables, WIFI, and a kitchen suitable for cookin...
Special Discounted Rates from $114 Per Couple
Vacation property rental on the Red Sea Israel
Eilat, Israel Vacation Rentals
Three brand new completely equipped situated only 800 meters from the beach and 100 meters from a Supermarket. Apartment consists of one bedroom with double bed, kitchen, bathroom with shower and Wc, a little garden with furniture. Eilat the southe...
Starting at 450 Per Week
Vivation Rentals
Beit She'arim, Israel Vacation Rentals
The apartment is completely furnished and meet your needs perfectly The apartment located in the center of tel- Aviv short distance from the beach Shopping malls and night life areas are nearby-great location Our apartment includes: � Fully e...
$100 Per Night
Romantic Weekend Getaway aboard a Luxury Yacht
Eilat, Israel Sailing & Yacht Charters
We offer Daily or Weekly luxury charter aboard a beautiful and comfortable Princess 23 m. situated in the magic world of the Red Sea....
Affordable Rates from 3,000 Per Group
Israel: Jerusalem to Eilat Bike - Freewheeling Adv
Jerusalem, Israel Bike Tours
Eight days: Cycling on paved roads and occasional hard pack desert tracks. Chosen one of the world's best trips by Bicycling, Outside, and Men's Journal...
Starting at 3,995 Per Person
Cycle Galilee and the Golan Heights - Freewheeling
Galilee, Israel Bike Tours
A wonderful way to visit some of the best sites Israel has to offer, by bike and on foot. You will cycle paved and unpaved roads, with short forays by foot throughout the vast and lush landscapes of north....
Starting at 3,995 Per Person
Detox Dead Sea-theUltimate Weight Lose Juice Detox
Dead Sea, Israel Detox Retreats
Press the reset button on your life in the magical Dead Sea spa. The Ultimate weight lose juice detox. Fantastic results. pick your Detox program here today! Juice fasting, Yoga, Meditation, 7 days Total reset. for women only....
Starting at $1,560 Per Event
ISRAEL FAMILY TOURS with the Israel Travel Company
Jerusalem, Israel Sight-Seeing Tours
Israel private & personal tours ,Can include 4 x 4 Jeep excursions in Israel. Licensed guide. Israel tours, tours in Israel ,adventure trips by camel & hiking tours. Safari to Eilat, Negev, Dead Sea, Judean desert, Jerusalem, Masada, Galilee, Golan...
Starting at $395 Per Group
ISRAEL TRAVEL COMPANY 4 X 4 Desert Jeep tours
Mitzpe Ramon, Israel Sight-Seeing Tours
Private tour with licensed guide to Israel , Petra -Wadi Rum in Jordan ,Negev Israel tours, Jordan tours, private desert jeep tours and 4X4 safaris in Eilat, Sinai, Jordan, Negev, Israel, ...
$550 Per Family
4 X 4 JEEP TOURS IN ISRAEL Off the Beaten Track
Mitzpe Ramon, Israel Sight-Seeing Tours
Jeep tours in Israel ,4 x 4 Jeep excursions in Israel. Licensed driver -guide or 4 x 4 self drive. Israel tours, tours in Israel by jeep 4x4, camel & hiking tours. Safari to Eilat, Negev, Dead Sea, Judean desert, Jerusalem, Masada, Galilee, Golan...
$550 Per Group
Marom Haifa Hotel
Haifa, Israel Hotels & Resorts
Picturesquely set on top of Mount Carmel, the Haifa Marom Hotel is a hotel you will not be able to resist, combining the latest in modern conveniences with the warmest of family hospitality. ...
350 Per Night
The Best Yachts Choice of Eilat-Red Sea
Eilat, Israel Luxury Cruises
Since 1996, Red Sea Luxury Yachts has offered the very best in yachting to customers and has built a favored reputation for intimate attention to detail and unparalleled personal service. Red Sea Luxury Yachts offers a multilingual team...
Rates from $2,000 Per Night
Beautiful Old Jerusalem Vacation Home
Jerusalem, Israel Bed & Breakfasts
An old Jerusalem Home with 2 Vacation units. 1 Double room sleeps 2, and 1 family room,sleeps 4, located in the neighborhood of Baka , very close to most of Jerusalems' attractions, on the street there are many shops, cafes, and public transport....
$120 Per Night
|Link Code


text:
The feds said 48-year-old Dr. Farid Fata misdiagnosed patients with cancer to justify unnecessary treatments and gave chemotherapy to end of life patients who couldn't benefit from the treatment.
Tuesday, federal agents raided Fata's Oakland Township mansion where paperwork and personal belongings were boxed up.
The FBI also raided Fata's offices across metro Detroit. The doctor owns and operates Michigan Hematology and Oncology Centers, which has offices in Clarkston, Bloomfield Hills, Lapeer, Sterling Heights, Troy and Oak Park.
The feds said a patient who fell at one of Fata's offices later died from a head injury. At the doctor's insistence, we're told he was given chemotherapy before being transported to the emergency room for treatment.
He is also accused of submitting fraudulent claims to Medicare, raking in $35 million in a two-year period.
Fata was arrested Tuesday morning.
The U.S. Attorney's Office has setup a hotline for Dr. Fata's patients to get their questions answered. That number is 888-702-0553.
KSAZ-TV & KUTP511 W. Adams St.Phoenix, AZ 85003Phone: (602) 257-1234Fax: (602) 262-0177


text:
Heart Failure
Heart failure means that your heart muscle does not pump as much blood as your body needs. Failure does not mean that your heart has stopped. It means that your heart is not pumping as well as it should.
Ongoing (chronic) heart failure is a lifelong, progressive condition that may require many lifestyle changes. Symptoms may include:
Over time, symptoms may get worse (be progressive) until they are always present.
Heart failure can also develop suddenly. This is called acute or sudden heart failure. Sudden heart failure is a medical emergency that causes rapid and severe shortness of breath, a sudden irregular or rapid heartbeat, and a cough that brings up foamy, pink mucus.
Treatment for heart failure usually involves managing the causes of heart failure and relieving symptoms. Effective treatment may reduce the need for hospital stays and the risk of premature death. Diet and lifestyle changes along with medicines may help to manage symptoms. In some cases, surgery may help treat underlying causes, such as coronary artery disease or heart valve problems.
eMedicineHealth Medical Reference from Healthwise
This information does not replace the advice of a doctor. Healthwise disclaims any warranty or liability for your use of this information. Your use of this information means that you agree to the Terms of Use. How this information was developed to help you make better health decisions.
To learn more visit Healthwise.org
© 1995-2012 Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.


text:
See your colors on these designs right now!
Enter your colors here, then click the icon below any design to preview it in your colors.
Recommended Just For You
Customer Raves & Reviews
Adorable tags!
Mustache You to Wed Wedding Favor Tags These tags arrived promptly and were packages well to avoid any damage. They are so cute to go with my Vintage carnival theme! I plan on attaching these to rock candy sticks as favors and cannot wait for people to see them!!
Mustache You to Wed Foldover Pockets I love my invitations! I got my save the dates through Magnet Street and I was able to use my saved colors and keep the same theme for my invitations!
Great invitations
Mustache You to Wed Rectangle Invitations Ordering was easy and even better with the discount code we found in a postcard sent to our house. Proofing was done before checkout and the invitations were delivered in a very sturdy box with all the cardstock neatly packaged. Definitely will use Magnet Street for our wedding programs and welcome packages for our guests. maybe even the table numbers!
Program Fans
Mustache You to Wed Wedding Program Fans These came in record time and were awesome quality!
Absolutely wonderful
Mustache You to Wed Save the Date Magnets Loved the different designs that you could chose from. Wonderful assortment of sizes, and I loved that you could then further customize the fonts and colors of the design you chose. Quick production and delivery time. Couldn't ask for better!


text:
Today I would like to tell you about one of my very favorite films. It's a film so hilarious that I once had a date end prematurely when I insisted that we watch it, and then proceeded to crack up when when were supposed to be cuddling.
I regret nothing!
Netflix description:
"Television executive R.J. Fletcher (Kevin McCarthy) tries to sabotage the wild success of a rival low-rent, wacky station run by slovenly dreamer George Newman (Weird Al Yankovic) and Bob (David Bowe) -- leading to a telethon showdown. Only George's on-air local misfits can help save the day. Jay Levey directs and Victoria Jackson, Stanley Brock and Michael Richards co-star in this daring, out-there, over-the-top comedy."
Along with Monty Python and the Holy Grail and Mel Brooks' Spaceballs, I rank UHF as one of the funniest movies ever made. It is over-the-top goofy in a way that only something written by Weird Al could be. He plays a loser named George Newman who somehow becomes the manager of a crappy, hole in the wall, TV station. At first, things don't go so well...but once George starts using his overactive imagination to produce original programming, the station -- Channel 62 -- quickly becomes top dog in its market. Can George handle the pressure that comes with being number one?
The TV station concept is perfect for Weird Al, since it allows for a variety of random gags to be thrown out in rapid fire. We see promos for shows like "Bowling for Burgers", "Strip Solitaire", and "Conan the Librarian", while meeting a variety of ridiculous and lovable characters. Our villain, RJ Fletcher, is the perfect cliche of an evil businessman...and George Newman's own staff consists of a young Michael Richards (as the dim-witted children's show host Stanley Spedowski), as well as a pre-Nanny Fran Drescher (as an annoying secretary).
UHF figures into many of my childhood memories. I remember laughing uncontrollably with my best friend the first time we saw the scene in which Weird Al hits a clown in the face with a frying pan (we must have rewound the tape 30 times to watch that moment over and over again -- even in slow motion); I remember being teased by a teenage Harmony House employee when I bought the UHF soundtrack (my first compact disk!); and I remember making out with my first girlfriend while watching the movie, and trying in vain not to crack up. I have seen UHF so many times over the years that I can recite most of it line for line by memory. One of my favorites: "Broads don't belong in broadcasting!" (I'd love to hang a poster with that quote on the wall at work, but some people just don't have a sense of humor, so I probably shouldn't do it).
What else can I say? There's no political message in UHF, nor any deep commentary on the human condition. Doctor Strangelove this is not. Rather, it is just pure stupidity, and I love it. There is an offbeat innocence to UHF which even hardened comedy junkies should find charming, and I recommend it to everyone who has a soul.
5 out of 5.


text: Hint: Level 2: Easy completion Wii code Go up the two ladders. When the flame goes up the ladder, go down the ladder slightly (it will go down), then jump onto the moving platform. Then, jump onto the non-moving platform to the right. After this, jump onto the other moving platform. Be careful -- if you jump too late, Mario will die. Next, jump onto the non-moving platform to the right. Repeat the process with the flame. Then, jump onto the little platform and go up the ladder to Pauline.


text:
Local agencies welcome the state's new commitment in helping to solve rape cases. Each rape case presents challenges unlike any other crime."Any type of criminal sexual conduct case in and of itself is a challenge for law enforcement," said Ferndale Police Chief Tim Collins.When you have a bank robbery, you go to the bank, but when you are dealing with a rape case, it is so much more complex.The news that the state is making a new commitment to solving rape cases is welcome to Michigan police agencies.Collins has worked more criminal investigations than most police officers in Michigan. A veteran of 37 years in law enforcement, the chief outlined for us the challenges in working any rape case."The sensitivity of the victim is always first and foremost in our mind," he said.Collins realizes some rape victims initially will not come forward."The victims themselves in some cases because of the trauma of the incident and just the individual involved may or may not report it in a timely manner, and that's certainly not a criticism. Every individual is different," he explained.Once a rape case is opened, there are many more investigative spokes to the wheel than almost any other crime."That individual will be transported to a hospital in many cases for a rape kit. The hospital has a role to play with the evidence that is taken at the hospital, and then the crime lab plays a role because that has to be analyzed in a specific way," Collins said.The challenges make each case unique, and the rape victim may experience mental terror and continue to be haunted until there is an arrest and conviction in the case.Everyone is hoping the state's new commitment will help close some of these unsolved rape cases.
25 FOX DriveDedham, MA 02026
Phone (781) 467-2525


text:
Enhance your well-being with wraps, masques, and body treatments. Select from a variety of services to refresh your body and soul. The perfect antidote for the stresses of modern life. Body treatments are designed not only to encourage rejuvenation and longevity but to cleanse, detoxify and nourish the skin. Our wide selection of treatments will meet your most specific needs.
Seasonal Body Ritual
Summer Ritual | $260 Mon-Thu, $270 Fri-Sun
Summery silkiness is in full swing! Dry skin soaks up vitamins and antioxidants in a nourishing Clementine oil bath. A squeeze of sweet and juicy Grapefruit extract begins this full body treatment as sea salts and rice bran oil combine to invigorate skin, exfoliating away all your rough areas. Next, a warming Nopal Cactus wrap tones, tightens and gives that skinny girl look without the diet! Walk out crisp and deliciously sweetened after a light massage using a hydrating body milk scented with Green Melon and natural Cucumber extract.
With the lingering scrumptiousness, you'll be the Summer breeze that floats out the door!
|Signature Treatment:
The Château Winery Ritual
Grapeseeds — Very few items in skin care can boast such an impressive array of benefits! Experience a wine bath that infuses the body with the anti-oxident power of grapeseeds, a Crush Body Scrub which exfoliates your skin leaving it feeling like silk and a De-Vine Mudwrap which provides exceptional re-hydration for the entire body.
|110 min $260
|110 min $270
De-Vine Mud Body Wrap
Enhance this treatment with a therapeutic Vichy shower which provides ultimate relaxation using a rain bar with independent showerheads above.
|80 min $140
With Vichy $150
|80 min $155
With Vichy $165
Château Winery Harvest Crush
Enhance this treatment with a therapeutic Vichy shower which provides ultimate relaxation using a rain bar with independent showerheads above.
|50 min $90
With Vichy $105
|50 min $100
With Vichy $115
Herbal Linen Wrap With Hydrating Hair Mask
|50 min $110
|50 min $120


text:
After a weekend of jet skiing in Palm Springs with his family, Tiger is lined up to take his sixth win this weekend at the Memorial tournament .
He took home the prize money last year from Muirfield Village and has 5 wins there.
No wonder, Tiger says on his website that he looks forward to playing this tournament. That's why the sweet bet is on him, coming off a Players Championship win and a strong season. He's moving into the house Jack built in Dublin, Ohio this Thursday, driving from Tee 1 at 1:16pm.
photo courtesy-Brian Wacker-pgatour.com,en.wikipedia.org/wiki/memorial tournament, tmz, bleecherreport.com, web.tigerwoods.com/index .


text:
By Matt Patches, Hollywood Staff
After building momentum with Natalie Portman and director David O. Russell in 2009, the adaptation of writer Seth Grahame-Smith's popular mash-up novel Pride and Prejudice and Zombies slowly sunk back down into the grave. Over the past few years, the project has had a rotating ensemble of potential leads, from Scarlett Johansson to Mia Wasikowska to Anne Hathaway. The project looked as good as dead - that is until today, when Pride and Prejudice and Zombies with Mortal Instruments star Lily Collins joined the Jane Austen-inspired horror flick.
According to The Hollywood Reporter, Collins is attached to star in the long-gestating hybrid under the direction of Burr Steers (17 Again, Charlie St. Cloud). With Walking Dead topping TV ratings charts and smaller genre movies like Warm Bodies making bank at the box office, zombies are still a hot topic in Hollywood. Pairing rising star Collins with the brain-eating beasts is a no brainer.
Seeing as the book cover of Pride and Prejudice and Zombiesis even more famous than the text inside, we had to wonder: does Collins have the right look for rotting flesh? Judge for yourself:
Follow Matt Patches on Twitter @misterpatches
More: We Talk to Lily Collins on the 'Mortal Instruments' SetA Lesson in Zombie Cock BlocksWould Lily Collins Have Made a Good Katniss Everdeen?
From Our Partners:Miley Strips Down in Raunchy Shoot (Celebuzz)Actresses Without Teeth Tumblr Is Creepy, Amazing (vh1)


text:
A sign on front of a Chipotle restaurant in Manhattan read "outage," but it doesn't say what it was out of. Disappointed customers couldn't believe it: a day without black beans how would they ever survive.
The mystery of the missing black beans was all over Twitter. One Tweet says "Chipotle is out of black beans. I'm bout to cry."
This one complained "how in the heck do you run out of black beans," accompanied by a picture of an empty container.
There were complaints about locations in New York and New Jersey not having their beloved black beans.
We contacted Chipotle, which says "We received a delivery of black beans in some of our restaurants that did not meet our quality standards, and we've chosen not to serve those. Those restaurants will have new black beans tomorrow."
When customers got that good news all was right with the world again.
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


text:
October is Energy Awareness Month. It's also the perfect time to get a home energy audit. An assessment typically costs $350, but now through the end of the year, Southeast Michigan residents can sign up to get it done for $100."What we offer is a very in depth assessment of your home that finds out where it's leaking air, which is the biggest energy drain on most homes," said Jacob Corbidae with the Southeast Michigan Regional Energy Office.The program is funded by a $30 million federal grant. More than 30 communities from the City of Detroit to Washtenaw County are eligible to participate."Everyone knows this is a good idea, but it's not clear who can you trust, what should you actually be doing, how are you going to afford it," Corbidae said.The BetterBuildings for Michigan program takes all of that guesswork out of it. They'll also install energy efficient light bulbs, shower heads and faucets and a programmable thermostat.Homeowner get a full report about trouble spots and rebates and incentives to make improvements.The best part? Making energy saving changes will save you money on your utility bills."The potential's pretty high. Depends on what you want to do," said Corbidae. "We've got some homeowners who have been saving as much as $800 a year. That's almost half of most homes' annual energy cost."So far, about 4,000 Michigan homeowners have taken advantage of this program, but it only runs through December. If you would like to sign up, visit www.MIHomeEnergy.org or call (313) 566-4801.
Aggressive wasps have forced an entire neighborhood in Detroit to come to a standstill.
KSAZ-TV & KUTP511 W. Adams St.Phoenix, AZ 85003Phone: (602) 257-1234Fax: (602) 262-0177


text:
Replacement handle, including foam grip and height adjustment joints.
This handle can be replaced using a standard screwdriver. It does not come with handle screws included, these will need to ordered separately. This handle is compatible with the following stroller models:
Want to receive updates about new products and promotions?
© 2014 philandteds.com


text:
Drug Notes
UPMC Patient Education Materials
Calculators and Assessment Tools
Anatomy Navigator
Conditions Navigator
Aortic insufficiency is a heart valve disease in which the aortic valve does not close tightly. This leads to the backward flow of blood from the aorta (the largest blood vessel) into the left ventricle (a chamber of the heart).
Aortic valve prolapse; Aortic regurgitation
Aortic insufficiency can result from any condition that keeps the aortic valve from closing all the way. A small amount of blood comes back each time the heart beats.
The condition causes widening (dilation) of the left lower chamber of the heart. Larger amounts of blood leave the heart with each squeeze or contraction. This leads to a strong and forceful pulse (bounding pulse
). Over time, the heart becomes less able to pump blood to the body.
In the past, rheumatic fever
was the main cause of aortic insufficiency. Now that antibiotics are used to treat rheumatic fever, other causes are more commonly seen.
Causes of aortic insufficiency may include:
Aortic insufficiency is most common in men between the ages of 30 and 60.
Aortic insufficiency often has no symptoms for many years. Symptoms may occur slowly or suddenly.
Signs may include:
Aortic insufficiency may be seen on:
A chest x-ray
may show swelling of the left lower heart chamber.
Lab tests cannot diagnose aortic insufficiency, but they may be used to rule out other disorders or causes.
If there are no symptoms or if symptoms are mild, you may only need to get an echocardiogram from time to time and be monitored by a health care provider.
If your blood pressure is high, then treatment with certain blood pressure medications may help slow the worsening of aortic regurgitation.
ACE inhibitor drugs and diuretics (water pills) may be prescribed for more moderate or severe symptoms.
In the past, most patients with heart valve problems were given antibiotics before dental work or an invasive procedure, such as colonoscopy. The antibiotics were given to prevent an infection of the damaged heart. However, antibiotics are now used much less often before dental work and other procedures.
You may need to limit activity that requires more work from your heart. Talk to your health care provider.
Surgery to repair or replace the aortic valve corrects aortic insufficiency. The decision to have aortic valve replacement depends on your symptoms and the condition and function of your heart.
You may also need surgery to repair the aorta if it is widened.
Aortic insufficiency is curable with surgical repair. This can completely relieve symptoms, unless severe heart failure is present or other complications develop. Without treatment, patients with angina or congestive heart failure due to aortic insufficiency do poorly.
Call your health care provider if:
Blood pressure control is very important if you are at risk for aortic regurgitation.
Bonow RO, Carabello BA, Chatterjee K, de Leon AC Jr, Faxon DP, Freed MD, et al; 2006 Writing Committee Members; American College of Cardiology/American Heart Association Task Force. 2008 Focused update incorporated into the ACC/AHA 2006 guidelines for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1998 Guidelines for the Management of Patients With Valvular Heart Disease): endorsed by the Sosciety of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. Circulation. 2008;118:e523-e661.
Carabellow BA. Valvular heart disease. In: Goldman L, Schafer AI, eds. Cecil Medicine. 24th ed. Philadelphia, Pa: Saunders Elsevier; 2011:chap 75.
Nishimura RA, Carabello BA, Faxon DP, et al. ACC/AHA 2008 Guideline update on valvular heart disease: focused update on infective endocarditis: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines endorced by the Society of Cardiovascular Anesthesiologists. Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2008;52:676-685.
Otto CM, Bonow RO. Valvular heart disease. In: Bonow RO, Mann DL, Zipes DP, Libby P, Braunwald E, eds. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 9th ed. St. Louis, Mo: WB Saunders; 2011:chap 66.
David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; and Michael A. Chen, MD, PhD, Assistant Professor of Medicine, Division of Cardiology, Harborview Medical Center, University of Washington Medical School, Seattle, Washington. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M. Health Solutions, Ebix, Inc.
Affiliated with the University of Pittsburgh Schools of the Health Sciences
Supplemental content provided by
A.D.A.M. Health Solutions. All rights reserved.
For help in finding a doctor or health service that suits your needs, call the UPMC Referral Service at 412-647-UPMC (8762) or 1-800-533-UPMC (8762). Select option 1.
UPMC is an equal opportunity employer. UPMC policy prohibits discrimination or harassment on the basis of race, color, religion, ancestry, national origin, age, sex, genetics, sexual orientation, marital status, familial status, disability, veteran status, or any other legally protected group status. Further, UPMC will continue to support and promote equal employment opportunity, human dignity, and racial, ethnic, and cultural diversity. This policy applies to admissions, employment, and access to and treatment in UPMC programs and activities. This commitment is made by UPMC in accordance with federal, state, and/or local laws and regulations.
Medical information made available on UPMC.com is not intended to be used as a substitute for professional medical advice, diagnosis, or treatment. You should not rely entirely on this information for your health care needs. Ask your own doctor or health care provider any specific medical questions that you have. Further, UPMC.com is not a tool to be used in the case of an emergency. If an emergency arises, you should seek appropriate emergency medical services.
For UPMC Mercy Patients: As a Catholic hospital, UPMC Mercy abides by the Ethical and Religious Directives for Catholic Health Care Services, as determined by the United States Conference of Catholic Bishops. As such, UPMC Mercy neither endorses nor provides medical practices and/or procedures that contradict the moral teachings of the Roman Catholic Church.
Pittsburgh, PA, USA UPMC.com


text:
Surfer Style Under $100
Make budget-friendly waves in shadowy palm-tree prints and psychedelic sun-soaked accessories.April 3, 2012 12:00 PM
Back Next
Richard Majchrzak/Studio D
Hang 10
Sunglasses, $29.90, Express; express.com.
No thanks, continue without linking accounts.Continue
Your information has been saved and an account has been created for you giving you full access to everything marieclaire.com and Hearst Digital Media Network have to offer. To change your username and/or password or complete your profile, click here.Continue
You now have full access to everything Marie Claire and Hearst Digital Media Network have to offer. To change your settings or profile, click here.Continue