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Nashville: It Aint Yours to Throw Away
Clip feat. "It Aint Yours To Throw Away" by Sam Palladio & Clare Bowen
Clip feat. "It Aint Yours To Throw Away" by Sam Palladio & Clare Bowen
Nashville clip feat. "Ball and Chain" duet by Connie Britton & Will Chase
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Nashville "Closer to Nowhere" guest performance by Kellie Pickler
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text: I get tired of seeing people post what they are having for lunch and dinner all the time. I thought that was bad enough, but now the new "fad" is posting photos of "sad food"....pictures of half eaten chicken, greasy looking pizza, wilted lettuce...etc...Really? Click here for full story. Okay, here is mine....leftover spicy Indian food.

subset: commoncrawl


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- 1 Hansen: Once again, Miller gets his man
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Oct 08, 2012
SAA CEO Mzimela resignsBack
New South African Airways|Public Enterprises|Embattled Government-owned Airline|Cheryl Carolus|Malusi Gigaba|Mayihlome Tshwete|Siza Mzimela|Tlali Tlali
"Yes we have received the resignation. We have accepted the resignation, but it was not with immediate effect," said Gigaba's spokesman Mayihlome Tshwete.
"She will remain with us for some weeks until we find a suitable person to act in the interim."
Mzimela was appointed CEO in February 2010.
SAA spokesman Tlali Tlali could not confirm the resignation when contacted for comment.
The Business Day website reported on Monday that Mzimela had described her resignation to her staff as "not a random move".
"I have given this decision careful thought and feel that now is the best time to relinquish my position as your CEO and allow somebody else to pilot the company into the future," she was quoted by the website.
Mzimela's resignation comes weeks after SAA's chairwoman Cheryl Carolus and six board members resigned.
Gigaba said he had only learnt about the mass resignation from media reports.
SAA was expected to report a R1.25-billion loss for the year ended March 31, when it holds its annual general meeting next week.
Last week, the airline won support from National Treasury after hard negotiations between it and the public enterprises department to support the airline, which according to the previous board has a debt to equity ratio of -359 percent, the website reported.
Last week, Treasury agreed to a R5-billion guarantee to enable SAA to borrow from financial markets.
Edited by: SapaComment Guidelines (150 word limit)
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Monish Bhola
Dr. Monish Bhola, DDS, MSD, is currently an Associate Professor and the Director of Post-Graduate Periodontics and Implantology at the University of Detroit Mercy School of Dentistry. Dr. Bhola is a Diplomate of the American Board of Periodontology and received his DDS from University of Detroit Mercy School of Dentistry and a MSD in Periodontics and Implantology from Indiana University School of Dentistry. Dr. Bhola has been practicing Periodontics and Implant Dentistry for the past sixteen years. His areas of interest include latest micro-surgical treatment modalities including oral plastic surgery, advance bone and soft tissue grafting for teeth and Implants, treatment of gingival recession and procedures for improving a gummy smile.
Dr. Bhola is currently the Vice-chairman of the postdoctoral directors organization. He lectures extensively at the national and international level and has several publications and abstracts in leading dental journals. Dr. Bhola has won several awards and recognition during his career, and is the recipient of the prestigious Bud and Linda Tarrson Fellowship award given by the American Academy of Periodontology Foundation in 2006.


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From WENN.com
The Grown Ups co-stars reteamed for the new sports comedy, but Hayek admits she had reservations about puckering up with James due to their real-life friendship.
Hayek reveals their children are very close, and she didn't want to risk upsetting the youngsters with the scene.
She tells Britain's OK! magazine, ""I actually did (want a body double) because I'm really good friends with his wife and children. I've been kissing people on the screen all the time, but we're actually good friends and the kids are good friends. It's the kid thing. By the way, it is really weird because he's actually a very good kisser. It was not a real kiss. It was through a fence. Nobody opened their mouth. But he does have good lips.""


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Stock of the Day: McCormick
The spice-maker serves up some bland earnings results
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Stretch Pique Wing Recliner Slipcover
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Stretch Pique Wing Recliner Measuring Guide:
Stretch Wing Chair Recliner Installation Guide
1. Locate the sew-in "Center Front" & "Center Back" labels. Note there are two pieces included. 2. Place mini footrest setting pleats a the four corners. 3. Line up top & back seam and center onto furniture. Put down & secure side and back velcro behind back legs and underneath.
4. Line up the vertical seam of slipcover's wings to match the chair's seams. Smooth from center out, tucking excess. 5. Bring cover forward onto the footrest setting pleats onto all four corners. Use elastic loops to secure underneath hardware. 6. Wrap elastic hem under seat & join velcro strips behind each leg. It's that easy!
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Treatment Options for HER2-Positive Breast Cancer Expand and Evolve
New results from three clinical trials highlight the evolving treatment options for women who have HER2-positive breast cancer. These cancers, which produce too much HER2 receptor protein, are a particularly aggressive form of the disease and account for approximately 20 percent of all breast cancer diagnoses.
In one trial, researchers showed that the investigational drug T-DM1 improved overall survival in women with advanced HER2-positive disease who had been previously treated with the HER2-targeted drug trastuzumab (Herceptin) and taxane chemotherapy. These updated findings from the EMILIA trial appeared October 1 in the New England Journal of Medicine. Read more > >
Adding Chemotherapy to Radiation Improves Survival for Some Patients with Rare Brain CancerCombination treatment substantially improves survival in patients whose tumors have two chromosomal deletions
HIV Linked to Rising Rates of Anal Cancer among U.S. MenHIV infections may explain increase among men but not women
HIV Drug Blocks Growth of HER2-Positive Breast Cancer CellsIn the lab, nelfinavir inhibited the growth of cells resistant to other anti-HER2 drugs
Exercise, Behavioral Therapy Reduce Menopausal Symptoms Caused by Breast Cancer TreatmentBehavioral therapy reduced frequency and perceived burden of hot flashes and night sweats
Also in the Journals: Study Compares Screening Methods for Lynch Syndrome
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Selected articles from past issues of the NCI Cancer Bulletin are available in Spanish.
The NCI Cancer Bulletin is produced by the National Cancer Institute (NCI), which was established in 1937. Through basic, clinical, and population-based biomedical research and training, NCI conducts and supports research that will lead to a future in which we can identify the environmental and genetic causes of cancer, prevent cancer before it starts, identify cancers that do develop at the earliest stage, eliminate cancers through innovative treatment interventions, and biologically control those cancers that we cannot eliminate so they become manageable, chronic diseases.
For more information about cancer, call 1-800-4-CANCER or visit http://www.cancer.gov.
NCI Cancer Bulletin staff can be reached at email@example.com.
Featured Article
Treatment Options for HER2-Positive Breast Cancer Expand and Evolve
New results from three clinical trials highlight the evolving treatment options for women who have HER2-positive breast cancer. These cancers, which produce too much HER2 receptor protein, are a particularly aggressive form of the disease and account for approximately 20 percent of all breast cancer diagnoses.
In one trial, researchers showed that the investigational drug T-DM1 improved overall survival in women with advanced HER2-positive disease who had been previously treated with the HER2-targeted drug trastuzumab (Herceptin) and taxane chemotherapy. These updated findings from the EMILIA trial appeared October 1 in the New England Journal of Medicine.
"Only a few studies in metastatic breast cancer have shown an improvement in overall survival. It's tough to do," said the trial's lead investigator, Dr. Sunil Verma of the Sunnybrook Odette Cancer Centre in Toronto. "The gain that we saw in this trial, an incremental improvement of 5.8 months, is one of the largest seen of any trial reported to date [in this disease]. And we're seeing that gain with less toxicity."
In addition, findings from two other clinical trials, presented at the European Society for Medical Oncology Congress (ESMO), provided more evidence that the existing duration of adjuvant treatment with trastuzumab in women with early-stage breast cancer should remain 1 year.
The trials are part of what has become an increasingly dynamic area of research for HER2-positive breast cancer.
The Food and Drug Administration (FDA), for example, recently approved pertuzumab (Perjeta), which also targets the HER2 receptor, in combination with trastuzumab and docetaxel for women with metastatic HER2-positive breast cancer. And T-DM1 is already being tested in a phase III trial as a first-line therapy for these women.
Researchers are also testing several investigational drugs that disrupt signaling pathways thought to play an important role in tumor resistance to HER2-targeted agents, said Dr. Ingrid Mayer, clinical core director of the Breast Cancer Program at Vanderbilt-Ingram Cancer Center in Tennessee.
"It is possible that, with so many active drugs against HER2-positive disease, we may eventually see some patients with stage IV disease being cured," Dr. Mayer said. But, she cautioned, much more research is needed before this would be possible.
In Advanced Disease, Improving Overall Survival
In the nearly 1,000-patient EMILIA trial, women who received T-DM1 had substantially better overall survival than women treated with the chemotherapy agent capecitabine (Xeloda) and another HER2-targeted drug, lapatinib (Tykerb): 30.9 months versus 25.1 months. (As previously reported, women who received T-DM1 also had better progression-free survival: 9.6 months versus 6.4 months.)
—Dr. Sunil Verma
T-DM1 is an antibody-drug conjugate that combines the monoclonal antibody trastuzumab and the chemotherapy drug DM1.
Trastuzumab has been linked to cardiovascular complications, but the two treatment groups had similar rates of cardiac events. Dr. Verma stressed, however, that clinicians should be cautious in interpreting the safety findings because patients who experienced cardiac toxicity with trastuzumab were not eligible for the trial, so those at increased risk for such complications were "selected out."
"We still need to do more studies, but T-DM1 doesn't appear to be any worse than capecitabine and lapatinib in terms of cardiac toxicity," Dr. Verma said.
Genentech, which markets T-DM1 in the United States, has submitted a biologics license application to the FDA to market the drug for women with locally advanced or metastatic HER2-positive breast cancer that cannot be treated with surgery and who previously received trastuzumab and taxane chemotherapy.
In Early-Stage Disease, Finding the Optimal Treatment Duration
For now, at least, the standard of care for women with early-stage HER2-positive breast cancer should remain 1 year of adjuvant trastuzumab. That was the conclusion reached by the researchers who led the HERA and PHARE trials, which tested different durations of adjuvant treatment. Updated results from both trials were presented at ESMO earlier this month.
The 5,000-patient HERA trial had three treatment groups: 2 years of adjuvant treatment with trastuzumab, 1 year of trastuzumab, or observation. After a median follow-up of more than 8 years, progression-free and overall survival were nearly identical in the 1-year and 2-year treatment groups, Dr. Richard Gelber of the Dana-Farber Cancer Institute reported.
Over time, the difference in progression-free survival between participants who received trastuzumab for 1 year and those who underwent observation narrowed. Even with the longer follow-up, however, women who received 1 year of trastuzumab lived 24 percent longer without their disease progressing.
"We know that this...is an underestimate of the effect of the treatment, because more than half of patients in the placebo arm actually received trastuzumab later on," Dr. Gelber said during a press briefing.
Although the rates of cardiac-related death and congestive heart failure were less than 1 percent in both treatment groups, women who received trastuzumab for 2 years had a statistically significantly higher incidence of reduced heart function (left ventricular ejection fraction), he reported.
The PHARE trial, meanwhile, compared 12 versus 6 months of adjuvant treatment with trastuzumab in the same patient population. The trial was smaller (3,380 patients), and it was a noninferiority trial. Noninferiority trials aim to demonstrate that the effectiveness of one treatment is not less than that of another treatment by more than a predetermined margin, suggesting that they are essentially equivalent.
Based on about 3.5 years of follow-up, the results "are inconclusive for noninferiority" between 6 and 12 months of adjuvant trastuzumab, explained the trial's lead investigator, Dr. Xavier Pivot of Université de Franche-Comté, at an ESMO press briefing. There was, however, "a strong trend in favor of 12 months of treatment," Dr. Pivot said.
The shorter treatment duration appeared to be safer, Dr. Pivot noted, with the percentage of women experiencing cardiac events nearly three times as high in women who received trastuzumab for 1 year (5.7 percent versus 1.9 percent). In the trial, however, "'cardiac event' was a composite variable" encompassing several heart-related problems, he explained, "so interpreting these data is not so easy."
Based on the results thus far, Dr. Mayer agreed, the standard of care for adjuvant treatment with trastuzumab in women with early-stage HER2-positive breast cancer should remain 1 year.
Although he concurred, Dr. Gelber stressed that the follow-up was not long enough to draw any definitive conclusions.
"There are some patients who may do just as well with the shorter duration," Dr. Gelber said.
The most recent analysis of patient subgroups in the PHARE trial will be presented in December at the San Antonio Breast Cancer Symposium. These findings may begin to identify women who need only 6 months of adjuvant trastuzumab, Dr. Pivot said.
Several other international clinical trials are testing shorter durations of adjuvant trastuzumab treatment in women with early-stage HER2-positive breast cancer.
Further reading: "For Some Breast Cancers, New Drug May Be Treatment Option" and "Pertuzumab Approved to Treat Some Metastatic Breast Cancers"
Cancer Research Highlights
Adding Chemotherapy to Radiation Improves Survival for Some Patients with Rare Brain Cancer
Long-term follow-up results from two clinical trials confirm that certain patients with anaplastic oligodendrogliomas, which account for less than 10 percent of brain and central nervous system cancers, live substantially longer if they are treated with a combination of chemotherapy and radiation therapy rather than radiation alone.
In the trials—both of which were launched in the mid-1990s—patients whose tumor cells had missing or deleted parts of chromosomes 1 and 19 and who received the combination treatment lived substantially longer than patients whose tumors had these deletions but who received radiation therapy alone. About half of patients diagnosed with anaplastic oligodendroglioma have these chromosomal co-deletions. The combination treatment did not improve survival for patients whose tumor cells lacked the deletions.
Because of the immediate implications for patients, NCI and the Radiation Therapy Oncology Group (RTOG) announced the results of one of the trials, RTOG 9402, in January before they had been published or presented at a medical conference. Findings from both studies were presented in June at the American Society of Clinical Oncology annual meeting and published online October 15 in the Journal of Clinical Oncology.
"These studies establish a new standard of care for patients with [anaplastic oligodendroglioma] tumors that harbor the 1p19q loss. No longer is radiation considered an adequate treatment for this patient population," wrote Dr. Mark Gilbert of the University of Texas MD Anderson Cancer Center in an accompanying editorial.
In the NCI-funded RTOG trial, participants whose tumors harbored both chromosomal deletions and who received high-dose chemotherapy with procarbazine (Matulane), lomustine (CeeNu), and vincristine (Vincasar), a regimen known as PCV, followed by radiation had a median survival of 14.7 years. Participants with the deletions who received radiation alone had a median survival of 7.3 years.
Median survival for patients whose tumors did not have the chromosomal deletions was less than 3 years, regardless of whether they received the combination therapy or radiation alone.
In the other trial, EORTC 26951, patients received radiation therapy alone or radiation followed by a standard-dose PCV regimen. The median overall survival cannot yet be calculated for patients with the chromosomal co-deletions who received the combination therapy, but there is a strong trend toward improved overall survival.
There is still some uncertainty about the preferred treatment for these patients, cautioned the RTOG trial's principal investigator, Dr. Gregory Cairncross of the University of Calgary and his colleagues. For example, because it can improve survival in glioblastoma, has fewer side effects, and is easier to administer than the PCV regimen, many oncologists appear to prefer using temozolomide (Temodar) to treat anaplastic oligodendroglioma.
In January, enrollment was suspended for a clinical trial called CODEL that was to include only patients with 1p19q deletions and randomly assign them to radiation alone or radiation plus chemotherapy with temozolomide. Because the evidence so strongly supports the combination of chemotherapy and radiation for patients with the chromosomal deletions, a radiation-alone arm would be unethical, trial leaders explained.
According to Dr. Bhupinder Mann of NCI's Division of Cancer Treatment and Diagnosis, the trial is being redesigned, with the hope of finalizing the changes by the end of the year.
RTOG 9402 was supported by grants from the National Institutes of Health (U10 CA21661, U10 CA32115, U10 CA25224, CA17145, CA21115, CA32102, and U10 CA37422).
Further reading: "Genetic Abnormality Predicts Treatment Benefit for Patients with Rare Brain Tumor"
HIV Linked to Rising Rates of Anal Cancer among U.S. Men
An increase in the incidence of anal cancer among men in the United States during recent decades may have been driven in part by the HIV epidemic that occurred during the same period, a new study suggests. The results, published in the Journal of the National Cancer Institute on October 4, provide a framework for understanding the rising rates of anal cancer in men and could help guide efforts to prevent the disease.
Dr. Meredith S. Shiels of NCI's Division of Cancer Epidemiology and Genetics and her colleagues estimated that between 2001 and 2005, more than 28 percent of anal cancer cases among men were associated with HIV infection, whereas only 1.2 percent of anal cancer cases in women were associated with HIV.
Although anal cancer is rare in the United States, the incidence has been increasing since 1940. Between 1980 and 2005, the rate of anal cancer in men in the general population rose 3.4 percent per year. The authors noted that half of this increase was due to cases of anal cancer occurring in men who were infected with HIV.
Men who have sex with men are at high risk of both HIV infection and anal cancer. Human papillomavirus (HPV) infections of anal tissue and anal precancerous lesions, which increase the risk of anal cancer, are common in this group. But the extent to which the incidence of anal cancer among people infected with HIV has affected incidence rates in the general population was not clear.
To explore this question, the study authors used data from the HIV/AIDS Cancer Match Study. They looked at the number of people with anal cancer infected with HIV in 17 U.S. states and metropolitan areas.
"HIV-infected cases have had a substantial impact on trends in anal cancer rates among men in the U.S.," said Dr. Shiels. She noted that rates among women have also increased, but the cause remains unclear. "Efforts to reduce the risk of anal cancer in HIV-infected men could have a sizeable impact on anal cancer rates at the general population level," she concluded.
This research was supported in part by NCI's Intramural Research Program.
Further reading: "HPV Vaccine Study in Costa Rica Yields Insights on Cancer Prevention"
HIV Drug Blocks Growth of HER2-Positive Breast Cancer Cells
Nelfinavir, a drug used to treat people infected with HIV, appears to halt the growth of HER2-positive breast cancer cells. Researchers led by Dr. Joong Sup Shim of the Johns Hopkins School of Medicine showed that, in the laboratory, doses of nelfinavir used to safely treat people infected with HIV inhibited the growth of drug-resistant HER2-positive breast cancer cells. The study appeared October 5 in the Journal of the National Cancer Institute.
Although several drugs are approved to treat HER2-positive breast cancers, tumors often develop resistance to these drugs, and new treatments are needed.
The researchers exposed seven genetically characterized breast cancer cell lines to drugs cataloged in the Johns Hopkins Drug Library, including anticancer drugs and drugs used to treat other diseases. (The protein-coding genes in the cells had been sequenced to determine whether they had mutations known to drive cancer.)
After finding that nelfinavir selectively inhibited HER2-positive breast cancer cells, compared with HER2-negative cells, the researchers teased out how the drug might work in HER2-positive cells. They found that nelfinavir inhibits a protein called heat-shock protein 90 (HSP90). Heat-shock proteins act as "chaperones," helping newly synthesized proteins to fold properly and stabilizing their structures. When the activity of HSP90 is blocked by nelfinavir, the proteins that it normally helps fold and stabilize may not work correctly.
HSP90 helps stabilize the HER2 protein and another protein in its signaling pathway called AKT. Therefore, blocking HSP90 activity may lead to the breakdown of HER2 and AKT or a decrease in their activity, explained the authors. This could slow or stop the growth of cancer cells that cannot function without abnormal HER2 signaling.
When the researchers tested nelfinavir in xenograft models of breast cancer, mice with HER2-positive tumors that were given nelfinavir had tumors less than half the size of those in mice that were not given the drug, and nelfinavir substantially reduced the levels of active HER2 (but not AKT) in the tumors. In cell-culture experiments, nelfinavir inhibited the growth of three HER2-positive cell lines that were resistant to the anti-HER2 drugs trastuzumab (Herceptin) or lapatinib (Tykerb).
The researchers hope that clinical trials will start soon. The rationale for clinical trials of nelfinavir is particularly strong for patients with resistance to the available anti-HER2 treatments, who have a poor prognosis, explained Dr. Jun O. Liu, the study's senior author.
The advantage of using a drug already approved for another disease, he added, is that the drug can likely skip phase I trials and go straight into phase II trials if tested at a dose currently used in the clinic. Another drug the research team found using this screening process, an antifungal/antibiotic called itraconazole, which inhibits tumor blood-vessel formation, leapt directly into phase II testing in cancer patients, he noted. (See the trial details here, here, and here.)
This research was supported by grants from the National Institutes of Health (CA122814, R01AI065983, and UL1 RR 025005).
Exercise, Behavioral Therapy Reduce Menopausal Symptoms Caused by Breast Cancer Treatment
Women with breast cancer who were suffering from treatment-related menopausal symptoms experienced symptom relief with cognitive behavioral therapy, physical exercise, or both, according to a Dutch study. The findings were published October 8 in the Journal of Clinical Oncology.
Dr. Neil K. Aaronson of the Netherlands Cancer Institute and his colleagues randomly assigned 422 patients to behavioral therapy, physical activity, an intervention combining the two, or a control group that received usual care. The purpose of the study was to evaluate the effects of psychosocial interventions and exercise on menopausal symptoms, such as hot flashes and night sweats, as well as on sexual functioning, psychological well-being, and health-related quality of life. The patients reported their symptoms at the start of the study and 12 weeks and 6 months later.
Compared with the control group, women who received the interventions had statistically significantly lower levels of endocrine and urinary symptoms, and behavioral therapy and physical activity had a positive effect on physical functioning. The researchers noted, however, that physical activity "affects primarily the frequency with which endocrine symptoms are experienced, but not the frequency of hot flashes and night sweats specifically." Cognitive behavioral therapy, in contrast, "seems to not only affect symptom frequency, but also the perceived burden of hot flashes and night sweats."
In a related editorial, Mayo Clinic researchers Drs. Debra Barton and Charles Loprinzi commented that, despite its limitations, the study demonstrated that "it is not sufficient to consider only biomedical influences [on symptoms]. …For complete symptom resolution, it may be necessary to address both the physiological expression and psychosocial context of the symptom."
Also in the Journals: Study Compares Screening Methods for Lynch Syndrome
A large, population-based, international study found that routine screening of colorectal tumors for DNA mismatch repair (MMR) genes was more sensitive than several other screening methods for identifying patients with Lynch syndrome. The researchers compared tumor MMR testing with three other screening strategies: the Bethesda guidelines, the Jerusalem recommendations, and another strategy based on an analysis of variables associated with Lynch syndrome. Their findings were published in JAMA today.
Although MMR testing offered only a "modest" diagnostic improvement, up to 15 percent of people with Lynch syndrome could remain undiagnosed without routine screening of colorectal tumors. And, identifying those with Lynch syndrome is critical to diagnosing relatives before they develop symptoms, so they can take preventive measures to decrease their risk of disease and death, explained the authors.
This research was supported by grants from the National Institutes of Health (CA67941 and CA16058).
Further reading: "Routine Lynch Syndrome Screening Varies at U.S. Cancer Centers"
Special Report
New Biomarker May Allow Earlier Diagnosis of Mesothelioma
Researchers have shown that the protein fibulin-3 may be able to distinguish patients with mesothelioma from people with similar conditions and from healthy individuals. Although preliminary, the results suggest that this protein may be a promising new biomarker for diagnosing the disease and possibly informing prognosis. The study was published October 11 in the New England Journal of Medicine.
Pleural mesothelioma, a disease of the tissue that lines the chest cavity and covers the lungs (the pleura), is an aggressive cancer often associated with asbestos exposure. Patients diagnosed with this disease have a median survival of 1 year.
Diagnosing mesothelioma early, when treatment may be most effective, is difficult because of its long latency period and the lack of reliable methods to detect the disease in its early stages. A protein called soluble mesothelin-related protein is the best-studied biomarker for mesothelioma, but the test for it has low sensitivity, meaning that it fails to detect mesothelioma in some people who have the disease.
In the study, supported by NCI's Early Detection Research Network (EDRN), Dr. Harvey Pass of the New York University Langone Medical Center and his colleagues identified fibulin-3, a protein important in cell-to-cell and cell-to-extracellular matrix signaling, as a potential mesothelioma marker.
The researchers measured fibulin-3 levels in plasma and pleural effusion samples from 142 patients with mesothelioma, 136 cancer-free individuals exposed to asbestos, and 93 patients with effusions not due to mesothelioma. The researchers also evaluated plasma samples from 91 patients with cancers other than mesothelioma and 43 healthy control subjects. Many of these samples came from EDRN.
Average plasma fibulin-3 levels were higher in patients with mesothelioma than in people without cancer who had been exposed to asbestos. Patients with mesothelioma and those without the disease could be distinguished with a sensitivity of 96.7 percent and a specificity of 95.5 percent at a cutoff level of 52.8ng/ml of plasma fibulin-3.
The researchers used another cohort of plasma samples to validate their findings, though the sensitivity and specificity fell to 72.9 percent and 88.5 percent, respectively.
"This is a totally new marker; something that we have never thought about in mesothelioma," commented Dr. Raffit Hassan of NCI's Center for Cancer Research, who was not involved in the study. "Fibulin-3 appears to be much better than serum mesothelin in terms of sensitivity and specificity."
Plasma fibulin-3 levels may also be helpful in monitoring response to therapy and disease progression. In 18 patients, fibulin-3 levels fell after surgery, and there was a trend toward rising fibulin-3 at the time of disease progression in 6 of these patients.
Fibulin-3 levels were higher in effusion samples than in plasma samples. In the few patients with both plasma and effusion samples, there was no clear relationship between the fibulin-3 levels in the two locations. Effusion fibulin-3 levels, however, were able to distinguish patients with mesothelioma from those with effusions not related to the disease, a welcome finding as it is difficult to distinguish patients with mesothelioma from those with benign effusions or malignant effusions due to other cancer types.
Likewise, effusion fibulin-3 levels were lower in patients with stage I or II mesothelioma than in those with stage III or IV disease. Patients with the highest effusion fibulin-3 levels at the time of surgery had shorter survival times.
The results are promising, though more studies involving a larger number of patients and prospective studies are needed to validate fibulin-3 as a biomarker for mesothelioma, noted Dr. Hassan.
"The other important thing would be to see if the levels of fibulin-3 could be used as a biomarker for response to chemotherapy or other biological therapies," he said. "Since mesothelioma is a very difficult disease to measure radiologically, it would be nice to have a sensitive and specific assay for monitoring response to treatment."
This research was supported by grants from the National Institutes of Health (U01 CA-111295 and U01 CA-113913).
Featured Clinical Trial
Comparing Relaxation Programs for Breast Cancer Patients Receiving Radiotherapy
Name of the Trial
Biobehavioral Effects of Relaxation for Women with Breast Cancer Undergoing Radiotherapy (2009-0976; NCT01202851). See the protocol summary.
Principal Investigator
Dr. Lorenzo Cohen, University of Texas MD Anderson Cancer Center
Why This Trial Is Important
Women with early-stage breast cancer usually have surgery to remove the tumor followed by radiation therapy. Depending on the characteristics of their cancer, they may also receive systemic therapies, including chemotherapy, hormonal therapy, targeted therapy, or a combination of these, before and/or after surgery. This multimodality treatment has helped many women survive breast cancer, but the rigors of treatment can leave women with other problems that may affect their health and sense of well-being.
Breast cancer surgery can result in lingering pain and affect physical functioning and range of body movement. Systemic therapies can cause sleep disruption, reduced ability to concentrate and to remember, fatigue, peripheral neuropathy, and other complications, whereas radiation therapy may cause fatigue, tenderness or swelling in the treated area, and, in some cases, peripheral neuropathy. These side effects can greatly affect a person's quality of life and cause stress, which may exacerbate a negative sense of well-being.
Radiation therapy following breast cancer surgery typically involves daily treatments for 4 to 6 weeks. Some doctors believe that this daily contact with patients may be an opportunity to teach them methods to reduce the severity of cancer symptoms and treatment side effects, as well as associated stress.
In this study, women with breast cancer who have had surgery and are scheduled to undergo radiation therapy will be randomly assigned to one of two different stretching and relaxation programs or to a control group that will receive usual care. Both active arms of the study will include stretching exercises, breathing exercises, and relaxation exercises. Women assigned to either of the relaxation programs will participate in 3 to 5 sessions a week for the duration of their radiation therapy and will then be asked to practice the relaxation techniques on their own every day for the following year.
All participants will complete questionnaires and 7-day sleep diaries before radiation therapy begins, midway through their radiation treatment, and during their last week of therapy, as well as at 3, 6, and 12 months after radiation treatment ends. Additionally, they will submit saliva samples before radiation therapy begins, during the last week of therapy, and at 3, 6, and 12 months after radiation treatment ends. The tests will measure levels of cortisol, a chemical in the body associated with stress, in their saliva at these different time points.
"We've seen from our previous research that women who participate in these types of programs throughout treatment have improvement in aspects of physical functioning and their ability to engage in daily activities," said Dr. Cohen.
"One particularly interesting aspect of the study is that we are measuring cortisol as an indicator of stress. We know that cortisol levels vary throughout the day, usually higher in the morning and tapering off over the course of the day, and there's evidence that a greater slope of this diurnal cortisol change is associated with better survival in patients with metastatic breast cancer. Our research indicates that women who practice mind-body relaxation programs, like yoga, tend to have steeper cortisol slopes.
"Another very important element of the study will be cost/benefit analyses between the women in each arm of the study, particularly in terms of documenting work productivity and functioning," he explained. "We're interested not only in whether women go to work or not, but also the degree to which they are able to focus on and be engaged in their work tasks, either outside or inside the home."
The study is taking place at the University of Texas MD Anderson Cancer Center in Houston.
For More Information
See the lists of eligibility criteria and trial contact information or call the NCI's Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). The toll-free call is confidential.
Community Update
Basser Research Center: Focusing on BRCA-Related Cancers
The recently opened Basser Research Center for BRCA has a unique mission. As the name suggests, the center focuses solely on BRCA-related cancers, from basic research to clinical treatment. Located at the NCI-designated Abramson Cancer Center at the University of Pennsylvania (Penn) in Philadelphia, the center was funded with an initial donation of $25 million from Mindy and Jon Gray in honor of Mindy's sister, Faith Basser, who died of ovarian cancer at the age of 44.
People with BRCA gene mutations are at higher risk than the general population for developing several kinds of cancer, particularly breast and ovarian cancer. (See the box below.) Researchers at the Basser Center aim to develop ways to prevent BRCA-related cancers or detect them early. And investigators at the new center believe much of the research will have broader implications.
"What we will learn about BRCA1/2 in terms of risk, prevention, detection, and therapeutics can be applied not only to other forms of breast and ovarian cancers, but to other cancers as well," said Dr. Susan Domchek, executive director of the center. "This is about understanding how cancers develop in these individuals, and, therefore, how we can target them."
Breadth and Depth
One of the Basser Research Center's strengths is that it draws on Penn's clinical and research resources. For example, women with breast and gynecologic cancers receive treatment at facilities that specialize in those cancers and genetic counseling at a center that specializes in evaluating risk for women's cancers. On the research side, the Basser Center draws on ovarian and breast cancer research programs, a translational research program, a center for personalized diagnostics, and a cell and vaccine production facility.
"The important thing is that this center has breadth and depth," said Dr. Domchek. "The basic biology is as important as how a woman can talk to her 14-year-old about why she is having a bilateral mastectomy."
By bringing together experts in immunotherapy, cancer genetics, molecular imaging, epidemiology, statistics, basic science, and clinical care, the Basser Research Center hopes to spur innovation, according to Dr. Chi Van Dang, director of the Abramson Cancer Center, which is funded in part by NCI.
"We have monthly meetings where all investigators present their work, and it really allows us to feed off each other," explained Dr. Domchek. Especially valuable, she noted, is that clinicians and basic scientists interact regularly, allowing clinicians to bring their questions directly to the scientists.
Many of the researchers have worked together before, Dr. Dang noted, but the creation of the center is really a "superglue" that brings people together.
Delving Deeper
The funding infusion from the Gray family has allowed researchers to dive more deeply into existing research areas. For example, Penn has a tumor tissue and biospecimen bank, and the new funding will help establish a section of the biobank for serum and plasma specimens, which will be used to develop and test biomarkers.
—Dr. Susan Domchek
"Early detection aided by biomarkers or imaging is incredibly important for us," stressed Dr. Domchek. Currently, no effective screening method exists for ovarian cancer, and the most common method of prevention is removal of the ovaries, sometimes at a relatively young age. And many women who have BRCA1/2 mutations also have a bilateral mastectomy to reduce their risk of developing breast cancer.
The funding has also enabled Basser researchers to delve into other new areas, such as new imaging capabilities and immune-based treatment strategies.
"Some of our researchers are studying specific molecular targets that will allow us to develop imaging agents [for] early detection of disease," explained Dr. Dang. "On the flip side, the same [molecules] might be targeted directly with immune cells that we can engineer. Ultimately, we want to develop vaccines and imaging techniques that will allow women [to forgo] those surgeries in the future," he said.
Although the proteins produced by BRCA1/2 are known to play a critical role in repairing damaged DNA, scientists do not yet fully understand how BRCA mutations can cause cancer or why mutations in certain regions of the genes appear to raise the risk of developing ovarian cancer rather than breast cancer, said Dr. Dang. Such an understanding would help researchers find ways to prevent and treat these cancers, noted Dr. Domchek.
When to Test?
The Basser Research Center is also using funds from the Gray's donation to improve outreach, education, and collaboration. This includes partnering with an organization called Facing Our Risk of Cancer Empowered (FORCE), an advocacy and support group for people affected by hereditary breast and ovarian cancer. The center has also created a webpage where people can request clinical or research information about BRCA-related cancers and has hired more genetic counselors who can help people find local resources or join a clinical trial.
Just the process of testing for BRCA mutations is fraught with difficult questions, Dr. Dang noted.
"At what age do you test, when do you inform patients of the results, what is the impact of those results, and how might the results affect the individual's psychological outcome," he said. "This research is not molecularly based, but it's extremely important for the mental and physical health of individuals."
In part because the Basser Center is spurring collaboration and innovation, and allowing researchers to dig more deeply into their projects, he hopes the findings will come more quickly. "Instead of coming out in 3 to 5 years, we'll be seeing information in a shorter timeframe," he predicted.
The funding will allow Basser researchers to do many new things, but "the most important thing that I've seen to date is that [the new center] really brings hope to people with these mutations," said Dr. Dang.
—Virginia Hulme
As an NCI-designated comprehensive cancer center, the Abramson Cancer Center is funded in part by a Cancer Center Support Grant (P30CA016520).
Further reading: "BRCA1 and BRCA2: Cancer Risk and Genetic Testing"
BRCA1 and BRCA2
When BRCA1 and BRCA2 work normally, the proteins they produce suppress tumor formation by helping to prevent uncontrolled cell growth. Sometimes, however, these genes contain harmful mutations that increase the risk of certain cancers. Women with mutations in BRCA1 or BRCA2 have greater risks of breast and ovarian cancers, as well as cervical, uterine, pancreatic, colon, stomach, gallbladder and bile duct cancers, and melanoma. Men with these mutations have a higher risk of breast, pancreatic, prostate, and testicular cancers.
Women with BRCA gene mutations are five times more likely to develop breast cancer than women without a mutation. Hereditary BRCA mutations account for about 5 to 10 percent of all breast cancers and 10 to 15 percent of all ovarian cancers among white women in the United States.
People whose family history suggests that they may have a harmful BRCA gene mutation can undergo genetic testing.
People with a harmful BRCA mutation have several options that may help reduce their risk of developing cancer: screening and other forms of surveillance; surgery to remove at-risk tissue; behavioral changes, such as losing weight and increasing physical activity; and taking drugs that have been shown to reduce the risk of breast cancer.
Director's Consumer Liaison Group to Meet Next Week
The NCI Director's Consumer Liaison Group (DCLG) will meet October 25 and 26 in Bethesda, MD. The meeting will feature presentations and discussions about how research advocates can help research findings make their way into routine clinical practice more quickly. Attendees will also hear an update on NCI activities.
The DCLG provides informed, nonscientific perspectives to the NCI director on promoting research outcomes that are in the best interests of cancer patients. Specifically, DCLG members provide insight into enhancing input, optimizing outreach, and promoting strong collaborations, all with respect to nonscientist stakeholders, in the interest of meeting common institute and community goals.
The meeting is open to the public and the agenda is available online. Please register by e-mailing Frances Young at firstname.lastname@example.com or calling 301-435-7788.
Meet NCI Experts at the American Public Health Association Annual Meeting
NCI will participate in the American Public Health Association (APHA) 140th Annual Meeting, which will be held October 27–31 at the Moscone Center in San Francisco.
APHA attendees can learn more about NCI's funding opportunities, cancer information resources, research, cancer control programs, and fellowships at NCI Exhibit Booth #2425. Attendees can also connect with NCI staff at the exhibit booth during the Meet the Experts Sessions and attend sessions involving NCI staff.
For a list of session with NCI staff and activities at NCI's exhibit booth, visit NCI's APHA 2012 webpage.
NCI Reaches Facebook Milestone
NCI's Facebook page topped 15,000 "likes" this week. Launched in 2010, the platform provides a way for users to interact with NCI, keep up to date with institute activities, and to share their own perspectives. The page includes questions and discussions initiated by group members, as well as links to NCI resources and cancer news.
"We consider this a significant milestone," said Deb Pearson, community manager for NCI's Facebook page who also helps oversee NCI's Cancer Information Service. "It's a great platform for people to request and share information, and it also informs us about the needs and stories of those in the cancer community. For a growing number of people, social media channels are how they choose to reach out. We are happy that we can accommodate them."


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WIPEOUT - "As Seen on TV" - Contestants include Baby Barber, Mid-Life Crisis, Crazy Rat Lady and Funniest Girl. Wild stunts on the Qualifier include The Tether Beater and The Fail Boxes, where players are licked and stamped by the Postal Opossums. Next on the course, players will need to have fancy footwork on Trippity Skippity Flippity Doo before getting their doughy parts powdered and rolled at the Wipeout Break-ery. Twelve hopefuls will then move on to Octopushy, with only six making it to the obstacle that every Country fan would appreciate -- Wipeout's Greatest Hits: Country Edition. Players will have to giddy up and quickly move along, dodging flying horse shoes, cowboy hats and giant biscuits before line dancing their way to the end through a swinging guitar. No sad tunes for the final three, who will be blazing happy trails on their way to the Wipeout Zone to battle it out for the best time and a cool $50,000. "Wipeout," hosted by John Anderson (ESPN's "SportsCenter"), John Henson (E! Entertainment's "Talk Soup") and co-hosted by Jill Wagner (MTV's "Teen Wolf"), airs THURSDAY, JUNE 27 (8:00-9:00 p.m., ET) on the ABC Television Network. (ABC/MIKE WEAVER) CONTESTANT
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If you eat lousy, you will more than likely sleep lousy. It found that people who reported the healthiest sleep patterns also had the most varied diets. These key nutrients have been shown to play a role in regulating sleep, so aim to eat them often for sounder slumber. I found this really great article at one of my favorite sites ...health.com. Check it out http://www.health.com/health/gallery/0,,20707983,00.html
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UM-Dearborn will host Summer Solstice event as part of the International Year of Astronomy
May 29, 2009
DEARBORN / May 29, 2009---The University of Michigan-Dearborn will host a Summer Solstice event in June as part of the International Year of Astronomy, a celebration of the 400th anniversary of Galileos first astronomical observation through a telescope.
Well spend the longest day of the year exploring the significance of the summer solstice to Neolithic cultures around the Earth as well as the property that was once Henry and Clara Ford's backyard, said Carrie Swift, assistant professor of physics and astronomy, who is coordinating the event.
The event, which is free and open to the public, is titled "A Long Day's Journey into Night" and will be held from 7:30 p.m. to midnight on Friday, June 19. Visitors may attend the entire event or choose select parts.
Beginning at 7:30 p.m., participants will meet at the Environmental Interpretive Center for a guided walk through the UM-Dearborn Natural Areas. Visitors can watch the sunset from the Henry Ford Estate terrace from 9 p.m. to 9:30 p.m. Participants may visit the universitys Observatory for a tour between 9:30 p.m. and 10 p.m. and, weather permitting, take part in astronomical observations from 10 p.m. to midnight.
For more information, visit http://astronomy.umd.umich.edu/ for a schedule of events at UM-Dearborn as well as Henry Ford Community College, or join the observatorys mailing list by e-mailing firstname.lastname@example.com.
CONTACT: Jennifer Thelen
The Office of University Relations
Room 1040, Administration Building
University of Michigan-Dearborn


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Small $16.99A penny saved is a penny earned... - This timeless classic is our #1 gift! Adorable ceramic piggy bank is available in three sizes. All have coin slots on top and rubber plugs on the bottom. We customize with your choice of name and design. Sorry, birth information and full names on Jumbo Banks with full designs only. Up to two names on large bank, and first name only on small bank. Don't forget to check out all our piggy bank styles and colors. All Paint Certified Lead Free!! Small 4 1/2" x 4 x 3 1/2" Large 8" x 7¾" x 6" Jumbo 10" x 9" x 7". Design prices may vary.
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Personalized Piggy Bank
I ordered the ladybugs & daisies design. My daughters room theme is purple ladybugs so I requested lavender ladybugs instead of red or pink and they were very accommodating said no problem. I received it and it's gorgeous!! It is so much more than I expected. I LOVE IT!! I would recommend it to anyone. I know why they are so popular as gifts, because they are so beautiful! I know some people had problems with it being broken when they received it but mine wasn't. I also read some complaints about the sticker placement but I didn't think it was that bad it was down almost in between the legs, I didn't think it was a big deal, some reviews made it sound like it was right under the tail, but it's not. Highly recommend this product :)
Personalized Piggy Bank
I bought 3 banks for my girls at Christmas and was worried how they would turn out, just because you know how ordering online can be ( not always what you think). However I was so excited when I opened them The paint job was beautiful. I examined them thinking they were too perfect and had to be stickers. The ladybugs, butterflies and flowers hot were the best! I also ordered the poodle and was so cute my only complaint was I wish they had used a brighter pink because its hard to see. I do agree the "my bambino" sticker they place on the bank is in a VERY bad place, and glad I didnt try the goo gone. I would have left the sticker had it been on the bottom out of site for the kids.
Personalized Piggy Bank
gift giver10/29/2010
Nice piggy bank....painting looks great. Wish they would not put their My Bambino logo sticker on the piggy banks backside (just under the tail). I realized they are promoting their product, but it should not be on this bank. And be very careful if you try to take if off. The "gum" from the sticker is very sticky and don't try to use GooGone, you WILL take off the painting design and ruin the entire bank, which I did on one of mine. Great customer service. UPS not great shippers and bank arrived smashed. They shipped another right out.
Personalized Piggy Bank
Repeat Customer12/24/2012
I purchased a Large piggy bank for our first son's 2nd birthday back in 2010 and absolutely LOVED the design and quality. It has since then become a family tradition to purchase a customized Large piggy bank for each of our children's 2nd birthdays. We will soon be purchasing piggy bank number three in 2013 and piggy bank number four in 2015. It is definitely worth paying the price for these piggy banks. You will not be disappointed with the quality of customized work. Thank you for such a great product!
Personalized Piggy Bank
best gift ever12/09/2010
I discovered My Bambino, a few years back when throwing a surprise baby shower for a friend of mine. Your website was the only shop that carried the blue and green dragonfly motif she had chosen for her nursery. Every since then, I have given personalized piggy banks to friends as gifts for their first child. I have 2 little boys of my own now and I am about to purchase my youngest son his own piggy bank. Love this item and will continue to purchase it as a unique gift for friends and family.
Featured negative reviews:
Personalized Piggy Bank
I ordered the pink piggy bank with the "Monkey Girl" design. No where on the website did I see that I should explain that I wanted the monkey and my daughters name on the same side. The picture on the design page led me to believe they would be on the same side of the pig. When I received the pig, the monkey was on one side, and my daughters name was on the other with some flowers and a palm tree. When I called customer service they said they would not change it and send me another pig and said I should've known this could happen after watching the Youtube video on their site. I didn't see the video, because it doesn't appear when you click to order the pink pig, but only if you click the picture with the three pigs. They did offer to paint a smaller monkey on the name side if I send the pig back and pay for shipping both ways. The shipping both ways will cost almost as much as it did to order it in the first place. No thanks! You would think if the design was "Monkey girl" th


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Inside Llewyn Davis is written and directed by the Coen brothers. It won the Cannes Grand Prix and is set during the 1961 Greenwich Village folk music scene. If you aren't excited for this one, you might be dead inside.
The song featured in the trailer is "Fare Thee Well", a folk classic, covered by Marcus Mumford of Mumford and Sons.
Inside Llewyn Davis is set for a Dec. 20th release.


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Green Leaves wrote:Guess I will be one who has to avoid contact with Don tomorrow, but here it is vomiting and diarrhea.
So I guess I'll send my Happy Birthday early...,.
Uff da!!!
That kind of "under the weather" is not wanted here either. Stay at least 500 miles away. Wait! You already are, so that's good.
Thanks for the early BD wishes!
Funniest thing...I was napping a little while ago in the recliner when the phone rang. I picked up the TV remote and tried to answer it. Then, the answering machine came on while I was still pushing remote buttons. Couldn't figure out why I couldn't get the phone to work. See what aging does to ya? The mind goes ka-put first, then everything else falls apart.


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Police tell Fox 2's Andrea Isom a 45-year-old man was riding across the intersection of Freeland and Fenkell Wednesday night when he was hit by a car and killed. Apparently several witnesses were standing around, and tell Isom the victim didn't even stand a chance.
VIDEO: Fox 2's Andrea Isom talks to witnesses
One witness says the driver was probably going 45mph. Fox 2 is told people speed at this intersection all the time, and the fact that the street lights are out make matters worse.
The 67-year-old suspected driver was arrested, police say for driving while impaired. He is in jail tonight.


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A dramatic police chase ended after 18-year-old Gabriel Stevenson,
behind-the-wheel of a red Ford Ranger pickup truck, lost control on an
icy roadway and crashed into Kevin McGraw's home near Six Mile and
Dixboro Road.
"I threw on my shoes and jacket and came out to see
if I could help whoever crashed in here, and the cops were on the PA
telling me to get back in my house," said McGraw.
The early
morning drama started several miles away at Six Mile and Napier Road.
Northville Township police officers in the area on patrol came across
the red truck. It was unoccupied. A short time later a call came in
that a car was on fire in the same location as two arson fires reported
in early December. That's when the officers spotted the suspect driving
"At that point a traffic stop was initiated by Northville
Township officers. After a brief discussion with the suspect, the
suspect pulled a revolver and shot one round at the officers and
Northville Township officers returned fire," said Public Safety Director
John Werth.
The suspect's bullets just missed the officer
and shattered a mirror on the police cruiser. Michigan State Police
joined in. They followed Stevenson for several miles before he crashed
his truck into McGraw's house. He tried to break into the home through a
window, but failed. That's when we're told the teenager turned his
attention to the police officers.
"A knife was seen by the
suspect. Northville Township officers used the less lethal force, which
is a bean bag weapon, and shot him four times with that weapon," Werth
said. "That did not stop him. What ensued after that is the suspect
came at one of the officers and he was fatally shot and he was
pronounced dead at the scene."
It was a Michigan State Police
trooper that fired the fatal shot. He has been put on administrative
leave pending the outcome of the investigation, which is standard
protocol. We're told dash cam video will show that the shooting was
We did reach out to Stevenson's family. They declined to comment at this time.
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


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Results 1 to 5 of 13
April 16th, 2013 11:04 PM #1
Names that fit my whimsical naming style!
My naming style usually fits into these categories (Whimsical, Medieval, Elegant, French, Vintage, or Nature) but one single name does not have to fit into more than one category, if that makes sense.... I'm wanting discover some names I haven't already, and wanted to get some pointers from all of you . Sorry if my style is kind of all over the place, haha. Use your imagination!
Thank you in advance!
Juliet, Arabella, Willow, Camilla, Genevieve, Lorelai, Clarice, Emmeline, Isla, Giselle, Eloise, Amelia, Mabel, Eliora, Aurelia, Emalina, Maëlys, Lumina, Lavender, Seraphina
Jeremy, Declan, Camden, Leo, Luca, Oliver, Rhys, Griffin, Milo, Micah, Yves, Rémy, Theo, Jasper, Gavin, Anders, Samson, Félix, Ollivander, Maxim
April 16th, 2013 11:17 PM #3Senior Member
- Join Date
- Jul 2012
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April 16th, 2013 11:19 PM #5Senior Member
- Join Date
- Jul 2012
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April 16th, 2013 11:24 PM #7Senior Member
- Join Date
- May 2012
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April 16th, 2013 11:26 PM #9Senior Member
- Join Date
- May 2011
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Over in the United Kingdom for a Bit
I have been in England for a couple of days now. I flew into Heathrow the other morning and spent a whole day doing meetings and trying to get acclimated. Of course it was a pretty tough trip, because I have been in Seattle and on the West Coast for the past few weeks. So I flew about as far as I could to get to London from the United States. I had a couple of problems finding a Bristol taxi yesterday and nearly missed my train. I was down there to look at the real estate for this project and there was a storm in off of the Atlantic which disrupted the schedule of the engineers and architects I was supposed to be meeting with. Of course the entire thing is about money. My job is to listen to them and make a report based on what they tell me about the costs and whether or not I think they can actually do things at the cost that they provide.
It is not going to be a short trip. It is going to be at least two months and probably three, but I am going to have some down time to go see things. I figure that Ella is going to come over before I leave. We have been to England before, about sixteen years ago. That was a rather short and rushed trip though and we did not think too much of the way that we did it. We did a whole lot of places, but basically rushed around from one tourist site to the next without getting much enjoyment out of it. We figure that this time we will target a couple of the best sites for us, but then spend a lot of time in them.Please Click Here


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Re: gray bar
manuelg wrote:figured it out
hint2: (i * 7, 43)
Does anyone agree that this hint should be taken out? I didn't know where to start and then I saw this and I figured it out without any python (or any coding) whatsoever. I would have liked to have had to dwell on this for a while. This hint made this level by far the easiest...


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© Jostens, Inc. NHL, the NHL Shield, and the word mark and image of the Stanley Cup are registered trademarks of the National Hockey League. All NHL logos and marks and NHL team logos and marks depicted herein are the property of the NHL and the respective teams and may not be reproduced without the prior written consent of NHL Enterprises, L.P. © NHL 2013.
All Rights Reserved.
Questions? Call 1-800-839-7125 or visit our FAQs.
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Could this be the next chapter in the Mission Impossible movie franchise?
For full effect, I recommend cuing up the cat & dog video to the (1:00) mark, push play on the Mission Impossible Theme Song video, and then hit play on the cat & dog video. You'll thank me later. :)
YouTube Description: Dexter and Gizmo escaping the kitchen - Couldn't figure out how the animals were letting themselves into the house while at work. Had to find out.


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Ether Crew LS Men's
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Select your size and colour to buy direct from Arc'teryx or from authorized online dealers.
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ACTIVITY/ MOBILITY;active;activity;aerobic;anatomical;aroebic;articulated;articulation;athletic;comfort;dynamic;endurance;ergonomic;fast moving activity;gardening;mobility;motion;movement;performance;range of motion;stretch mobilityARC; all products;arc teryx;arcteryx;arc'teryx;B.C.;bc;british columbia;canada;equipment;gear;innovation;innovative;outdoor;outdoor gear;performance;quality;sports equipment;technical;vancouver;CLOTHING;aparel;apparel;articles of clothing;attire;bekleidung;clothes;clothing;equipment;garment;gear;kleidung;sportswear;vêtements;vetements;wear;MOISTURE WICKING/ BREATHABLE;breathability;breathable;breathible;eliminating;moisture repelling;moisture removing;moisture wicking;quick drying;quick-drying;venting;wicking;wicks moisture;WARM CONDITIONS;climate;hot;spring;springtime;summer;summertime;temperature;temperatures;warm;warm weather activities;dry climate;CASUAL;urban;urban play;city life;lifestyle;stylish;CLIMBING;abseil;abseiling;adventure climbing;aid climbing;alpine climbing;apparel;ascent;belay;bouldering;climber;climbers;climbing;climbing equipment;climbing gear;climbing gym;climbing route;climbing routes;climbing wall;clothing;crag;cragging;equipment;face;free climbing;gear;holds;ice;ice climb;ice climbing;indoor rock climbing;lead climbing;mountain climbing;mountaineering;Rappel;rappelling;rock;rock climbing;rock climbing wall;scaling;scrambling;sport;sport climbing;summit;trad climbing;T-SHIRT;t shirt;t-shirt;tee;tank top;HIKING;adventure hiking;alpine;alpinist;alpinists;apparel;backcountry;backpacker;backpacking;equipment;gear;high alpine;hike;hiker;hikers;hiking;hiking climbing;hiking equipment;hiking route;hiking trip;hiking trips;mountain;mountain hiking;mountain top;mountaineering;mountains;outdoor adventures;peak;rambling;road hiking;scenic hiking;scramble;scrambling;trail;trail walking;trailhead;trailhead hiking;trails;walking;walking trails;wilderness;Randonnée;Randonnee;Randonée;Randonee;TREKKING/ BACKPACKING;adventure trekking;alpinist;alpinists;apparel;backcountry backpacking;backcountry trekking;backpacker;backpacking;backpacking trails;backpacking trip;backpacking trips;equipment;gear;high alpine;mountain;ski backpacking;travel;traveling;travelling;treking;trekker;trekking;trekking trails;trekking trips;trekking trips;Wandern;CASUAL;24;casual ;office wear;traverse;twenty four;twenty-four;urban;ALL PRODUCTS;all;everything;entire;collection;
150 g / 5.3 oz
Athletic Fit
Sizing Chart:
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Technical crew with mesh underarm and side panels to aid venting. Helius™ body is hard wearing for extended use; mesh fabric has an antimicrobial finish to reduce odour. Efficient at wicking moisture, this lightweight and breathable base layer draws sweat away from the body to keep you warm and dry. The silky feeling knit fabric is comfortable next to the skin, quick-drying, and hard wearing.
Learn More About This Product
Arc'teryx Fit Guide - Athletic Fit
Standing in as our "Arc'teryx Standard" fit, the complex patterns used utilize anatomical shaping and gussets to enhance motion and eliminate excess bulk. Trimmer than the Relaxed fit with room for a base layer, a light fleece mid-layer and a synthetic or down filled mid-layer.
To find out how to calculate your body measurements, view our Sizing Charts:
› Men's Tops | Men's Bottoms
› Women's Tops | Women's Bottoms
Full Feature List
Technical Features
- Moisture-wicking
- Breathable
- Lightweight
- Durable
- Quick-drying
- Flatlocked seams lie flat for added comfort
- Breathable, moisture-wicking panels under arms to aid moisture management
- Crew neck
Cuff & Sleeves Configuration
- Long sleeves
- 50+
- Helius™—100% polyester 112 g/m². A lightweight, breathable, stretchy, plain knit textile with a moisture wicking finish to promote evaporation.
- Viente™—100% polyester 140 g/m². Lightweight, highly air permeable knit mesh textile that has wicking properties for moisture management. An anti-microbial treatment controls odours.
- Machine wash in cold water.
- Hang to dry.
- Do not use fabric softener.
- Do not iron.
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Harry C. Sigman's gift will be invested in three endowment funds.Read more »
Read more »
The Y&S Nazarian Center's annual "one-day university" on Israel featured lively panel discussions of the Israeli high-tech sector, contemporary arts and the Jewish Renewal movement. In his keynote speech, U.S. Ambassador Dennis Ross urged the Israelis and Palestinians to each take steps to assure the other of their commitment to the peace process.Read more »
Panel Descriptions Read more »
SUNDAY, MAY 4, 9:00 a.m. - 4:00 p.m.
Read more »
Ari Shavit called on Israel to return to the imaginative and determined spirit of early Zionism at a Y&S Nazarian Center event on February 12, 2014.Read more »
Links to Israel news sources on the web.
UCLA Younes & Soraya Nazarian Center for Israel Studies • 11361 Bunche Hall • Los Angeles, CA 90095-1487 • Campus Mail Code: 148703
Tel: 310-825-9646 • Fax: 310-206-3555 • Email: email@example.com


text:
Narrow your search
Reflective service that organized user content from social networks into a timeline announces it is joining another company and will delete accounts tomorrow.
Thirst is one of the best iOS apps I've seen yet for catching up on hot news topics by category, with a smart search algorithm that uses the power of the Web to bring stories to you.
Pricing not available
Threadsy, a company that runs analysis on your social graph, will soon be owned by Facebook.
Having a hard time keep track of your Groupon, Living Social, RetailMeNot, retailer, and manufacturer deals? ChoozOn wraps them all up for you.
From SXSW, two very different proposals to handle content aggregators and attribution of articles and other work across the Web.
Twitter purchases Summify and its social-media news aggregator, but it's not clear as to how Twitter will be making use of the new product just yet.
What's a news producer going to do with an aggregation service? Do the business models mesh?
Retrevo's main function, to date, has been to provide tech buying advice to consumers. Its new service climbs over the ethical wall separating content from commerce.
One of the interesting things about cloud computing as a disruption to "traditional IT" is the experimentation and innovation it encourages. Take the new cloud aggregators.
Bing now scours a handful of deals sites to look for special offers users can find on their desktop, or their phones. The tool makes use of location as well, for finding deals on the go.


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The Vaults
The Vaults is an incredible venue located in the buzzin Cardiff Bay area. It is a real bank vault underneath an old large bank and is split into a main Techno room, a Funky House room and in the old bank itself above the vaults a new huge cartoon cinema chill out room. The sound system rocks, the lasers give the most intense visual element and most important of all, the people that attend are amazing fun friendly party people! Everyone is welcome....
The Vaults, 113-116 Bute Street, Cardiff, CF10 5EQ
Clubbing / Nightclub


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Order Line 0330 123 4123
Order Line 0330 123 4123
Product Code: 166369
Premium joinery-quality square-planed pine timber is ideal for interior joinery where a smooth finish is required
£2.48 per M
Premium joinery-quality square-planed pine timber is ideal for interior joinery where a smooth finish is required
"I ordered 3 packs. 2 of the packs were in their original packing however one were lose planks. These were obviously product that no one wanted as they were unusable. Makes the order expensive and I did not have enough timber to complete the job. Very inconvenient."
Our 'Big & Bulky 7-day' products have a delivery lead time of 7 working days. Big & Bulky deliveries are scheduled to be delivered between 7am and 8pm.
Wickes delivers 'Big & Bulky' products to mainland UK (Great Britain) addresses, we are unable to deliver to Northern Ireland or remote and offshore locations including the Isle of Wight.
If you have ordered a combination of 'Big & Bulky' products and non 'Big & Bulky' products with different lead times they will usually be delivered together, but where products are being sent from one of our partner suppliers this will not be possible.
This delivery information applies to 'Big & Bulky' products ordered online or by telephone. Go to our Delivery Information page for full delivery details of all our products and delivery methods.
(including 'Big & Bulky' 7-day delivery lead time products)
Up to £300
Next Day Delivery: £25
Saturday Delivery: £30
£300 and over
Next Day Delivery: FREE
Saturday Delivery: £5
Important: Delivery will be on the Saturday following the end of the delivery lead time
Set out below is a summary of our Returns & Refunds policies, for full details see our Cancellations, Returns and Refunds policy
You can return any unused product to us in its original condition for a refund within 30 days of delivery to you. Please note that we may be unable to accept the return of made-to-measure products unless they are faulty or have been damaged in transit.
You can cancel any online order and receive a full refund (including standard delivery charges) at any time before the product is dispatched or within 14 days starting on the day after delivery.
Please note that if you cancel an order after the product has been delivered, you will be responsible for returning the Product to us at your cost within 14 days of the cancellation of your order. You can arrange for the product to be collected, by us or our nominated carrier, or return the product to your local Wickes store for free, with proof of purchase.
In the unlikely event that a delivered product is faulty or damaged, we will exchange it or provide you with a refund, as long as we are notified of the product's fault within 30 days of it being delivered to you.


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Your Local Satellite
Singur, India
5 Day forecast for Singur, India
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Odile Soaks Baja Calif.; Edouard Weakens In The Atlantic
Tropical Storm Odile is soaking the Baja California with Polo likely to sideswipe Mexico. Edouard weakens in the Eastern…More >
Odile's Downpours Drench The Southwest This Week
Heavy rain will drench the Southwest this week from Tropical Storm…More >
Racing Wildfire Engulfs Homes In California Town
A fire driven by fierce winds raced through a small town near the Oregon border on Monday, burning a church to the ground,…More >
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You too can help save our planet and put money back in your wallet. Learn how you can take the first steps to reduce your environmental impact, including driving green, easy ways you can conserve water, and energy saving tips. To learn more and discover the benefits of going green, visit WeatherBug's green living section. More >
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Customer Testimonial
Afghans & Pillows department
Find personalized blankets & afghans embroidered with names or monograms. Great as gifts for mothers & grandmothers!
Afghans & Blankets for WomenFind personalized afghans and blankets for women embroidered with names or monograms. Personalized afghans and blankets make great gifts for mothers & grandmothers, or even the entire family, and are a perfect way to tell them how special they are. You can even choose a pillow in a variety of designs and have it personalized. No matter who your recipient is – mother, grandmother, sister, a special friend, or your daughter – a personalized gift just makes it more personal. Browse and find more meaningful gifts today!


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woohoo for the massage (and the little joke, that was funny!)
I confess that I fell asleep putting Mia to bed. Now it's 3.18am and I'm wide awake.
I confess that unemployment is starting to mess with my mental health. I need to be doing something useful or I get depressed.
Ashley - 25, Chris - 27, Elizabeth - 9-22-04, Alexis - 12-19-08
Ashley - 25, Chris - 27, Elizabeth - 9-22-04, Alexis - 12-19-08
Hi Ashley!!
Hey Cass! I haven't seen you on much lately - been busy?
Ashley - 25, Chris - 27, Elizabeth - 9-22-04, Alexis - 12-19-08
I confess that I add things to my "to do" list after I've already done them, just so that I can cross them off.
I confess I feel great apprehension at sending this email I've written to my mother about our conflicting religious beliefs. I've not gone on the attack and kept it peaceful and "loving", but I'm scared it will build a wall between us. And I don't want that.
I'm obsessed with the computer too. It's especially hard in the new house now that the computer aren't in the living room. I kind of miss the apartment for that reason LOL
I asked DH to get me a laptop so that if Josh is watching a tv show or entertaining himself I can hang out with him and go online at the same time...
She said she wasn't trying to save me or push it on my, but wanted me to keep an open mind . . . which I think is really funny considering the vast array of religions of the friends I keep. Mind open. Check.