text:
Dennii's Q & A
Favorite Sport/Team
Love drifting (motorsport)!!! Don't have a fav team :)
Favorite Movie/Actor
The Beach & Leonardo Dicaprio!
Go-to karaoke song
Gone by Justin Timberlake!
My first job
Cashier @ the Renaissance Festival
Piercings/Tattoos (How many? Where?)
Got one extra set of boobies in a Fafi pin up doll tattoo located on my right rear lower back above my bum ^.^ Have three piercings, my ears and belly button.
Mac or PC?
Totally Mac addict.. Best investment ever!
Nintendo, Xbox 360, PS3, or don't game?
BIG gaming nerd! PS3 love Gran Turismo & I play MMORPG computer games such as World of War Craft :)
What fun fact, talent or superpower of yours should guys know about?
I am a sponsored race car drifter heading toward pro & could probably beat you on the track drifting any day :) Oh yea I also personally know how about cars & to work on them!
What's the most memorable pick up line you've ever heard?
Gosh theres soo many but the most memorable was possibly when guys say I'm an angel and must have hurt falling from heaven....
What's the craziest thing you've ever done?
Started drifting...its such an adrenaline rush but its crazy to think how I am not scared of it, which mind boggles me!
What's the most unusual place you've ever hooked up? How'd it go?
In a secluded area of a club, um very well.... lets just say we hid under the table!
What's in your purse or pocket right now?
Lets see.. money, makeup, credit cards, flash light, comb, business cards and receipts...nothing exciting
What do you feel most comfortable wearing?
Just boy shortie undies from VS I love them :)
Would you rather have boring sex all the time or an amazing romp once a year?
I gotta go with the amazing romp once a year. I like to enjoy sex not act like I'm a old uninterested couple, eek you have to agree!
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
Tequila with Johnny Depp... why the hell not?!?


text:
Doom 3 BFG Edition Walkthroughs for Xbox 360
Also on: PC PlayStation 3
Doom 3 BFG Edition walkthroughs. Please remember to bookmark this page and come back for Doom 3 BFG Edition guides and walkthroughs which will be located here as soon as we get any Doom 3 BFG Edition walkthroughs.
Try our Xbox 360 Index for more cheat codes for other X360 games.
Popular Xbox 360 Games
Grand Theft Auto 4
The Sims 3 Pets
Midnight Club: Los Angeles
Grand Theft Auto 4: The Ballad of Gay Tony
The Elder Scrolls V: Skyrim
Call of Duty: Black Ops 2
Batman: Arkham City
Call of Duty: Black Ops
Saints Row The Third
Grand Theft Auto: Episodes from Liberty City
Forza Motorsport 4
Mafia 2
Call of Duty: Modern Warfare 3
Red Dead Redemption
LEGO Batman 2: DC Super Heroes
The Sims 3
Saints Row 2
Dragon Ball Z: Ultimate Tenkaichi
Saints Row
Lego Star Wars: The Complete Saga
Sleeping Dogs
Also on: PC, PlayStation 3, check out those pages for more help with this game.

subset: commoncrawl


text:
ROOKIE BLUE - "Might Have Been" - Andy and Gail go undercover as cocktail waitresses to clean up a drug-infested club, but get more than they bargained for when their fellow waitress turns out to be involved with a vicious criminal. Meanwhile, Traci wrestles with feelings for her old flame, Detective Barber, Dov tries to weather the storm when a young woman files a complaint against him, and Andy unwittingly opens up to Sam about her commitment to Luke, on "Rookie Blue," THURSDAY, JUNE 30 (10:00-11:00 p.m., ET), on the ABC Television Network. (ABC/ANNABEL REYES) MISSY PEREGRYM
Use a Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook name, photo & other personal information you make public on Facebook will appear with your comment, and may be used on ABC's media platforms. Learn more.


text:
As I mentioned in my last post, having cooked rice, beans and sauces on hand enables me to throw together fast meals. Roasted Garlic Marinara and a bit of stock created a delicious sauce in this dish. I used cooked rice and as you can see, it got a bit mushy. If you like a more al dente grain, you can cook the rice and the dish will still be done in 30 minutes.
Italian Chickpeas, Sweet Potatoes and Greens
- 1 sweet potato, cut into small pieces
- 1 c vegetable broth
- 1.5 c chickpeas (cooked)
- 4 c chopped collards
- 1 c roasted garlic marinara
- 1 T balsamic vinegar
- Chili flakes if deired
- Goat Cheese Crumbles or Lemony Almond Pate
- 2 C cooked Rice
- In a 12 inch skillet over high heat add the potatoes, broth and chickpeas. Cover and cook for 15 minutes
- Next, add the marinara, vinegar and rice. Cook for 15 more minutes. Serve with your favorite nut cheese or nutritional yeast flakes
I'm also going to train my dog Jorda to use the treadmill! She is so sensitive to salt and cold weather. She's going totally stir crazy, but when I take her out for a walk she gets too cold and her feet hurt, so she begs to go back home. Does anyone here have any booties they recommend? We have not had lucky with any of them staying on her feet.
|I miss the nice weather!
I just had the best green smoothie. Organic spinach, banana, chia seeds, chickpeas, cinnamon and ginger. Oh yeah!


text:
GREY'S ANATOMY - In the first hour of part two of the season finale of ABC's "Grey's Anatomy" -- "Deterioration of the Fight or Flight Response" -- Izzie and George attend to Denny as the pressure increases to find him a new heart, Cristina suddenly finds herself in charge of an ER, and Derek grapples with the realization that the life of a friend is in his hands. In the second hour, "Losing My Religion," Richard goes into interrogation mode about a patient's condition, Callie confronts George about his feelings for her, and Meredith and Derek meet about Doc. Part two of the season finale of "Grey's Anatomy" airs MONDAY, MAY 15 (9:00-11:00 p.m., ET) on the ABC Television Network.
Use a Facebook account to add a comment, subject to Facebook's Terms of Service and Privacy Policy. Your Facebook name, photo & other personal information you make public on Facebook will appear with your comment, and may be used on ABC's media platforms. Learn more.


text:
Koolscapes Fountain Jet Pump
by Koolscapes | Item #: 400603 |Model #: FJ-200 |
This pump is ideal for statuary and fountains.
These magnetic driven pumps are designed to operate with minimal energy consumption, resulting in low operating costs. The compact size is ideal for use in statuary, fountains and limited space applications. They are also designed to operate continuously and have a flow control to regulate the output of water. They come with suction cups to anchor the pump firmly.
- Suction base for firm positioning
- Flow control to regulate water output
- Magnetic driven motor
- Energy efficient
- UL and ULC approved
- 200 gallons per hour
Assembled Country
Component Country
Ask & Answer
Warranty Information1 year
There is no additional information available for this item.


text:
Lake Austin Spa Resort
What are you in the mood for: A relaxing nap in a hammock or an energizing cardio class? How about both? Enjoy it all when you stay at Lake Austin Spa Resort. Just want a world-class massage and a relaxing day by the pool? Visit our extraordinary LakeHouse Spa.
#1 Spa in the US, Celebrated Living
#1 Fitness and Wellness Resort, Fodor's Travel
Gold List Platinum Circle, Condé Nast Traveler
Top Destination Spa, Travel + Leisure
View All Accolades
Lake Austin Spa Resort
1705 S. Quinlan Park Rd. Austin, TX 78732
Map and Directions
Phone: (512) 372-7300
Request a Reservation
Hours of Operation
Property Video
Get an insider's look at our property with this video or view our gallery for more video and photos. From tranquil waters to lush gardens and beautiful guest rooms, picture yourself at Lake Austin Spa Resort.
Lake Austin Spa Resort features 40 casually elegant guest rooms designed by one of the top interior design firms in the world. Each room is finished to…
LakeHouse Spa
We offer over 100 spa services designed by our in-house experts and inspired by our natural setting. These customized spa treatments - including massages, body…


text:
C and C++ Open-Source Projects
C is a lower-level, procedural language, and one of the most commonly used in software, thanks to its power and portability. C++ is an evolution of C with new syntax and support for object-oriented development. Both flavors are still heavily used today.The GNU Coding Standards The Rook's Guide to C++


text:
I read this blog: Rants From Mommyland and this is so true!
On numerous occasions I have found myself brushing off not so cool comments from strangers. Some examples:
At Country Fest (which was held at the end of June) a woman said, "Oh no don't get up you look like you're ready to pop." I was only 6 months pregnant at the time.
At the gas station a gray haired man watched me put creamer in my coffee then said, "You really shouldn't be drinking that it's bad for the baby." It was decaf, but I didn't tell him that.
I have gotten the "You don't even look pregnant" from people I know and I too have wondered, "What exactly does that mean?" Maybe I just look fat today instead.
Please don't touch my belly. If you ask I may say okay, but I'm probably still not comfortable with it unless you're my close friend or my family member. My mother in law doesn't even touch my belly.
Do you have any annoying stranger experiences you'd like to share? I'd love to read them please comment below.
Blog brought to you by:


text:
Yoga, Meditation, Healthy Recipes & Natural Lifestyle Tips
How to Cleanse and Protect Your Liver Naturally
Wai Lana, host of the long-running PBS series Wai Lana Yoga, shares tips on liver health.
Knowing the important role that my liver plays in keeping me healthy, I often share this simple truth with others: "Take care of your liver now, and your liver will take care of you." A healthy liver will cleanse and nourish your blood, regulate your hormones, break down fat and cholesterol, form blood-clotting proteins, and store iron and other essential vitamins throughout your entire life.
Unfortunately, environmental pollution, chemicals and pesticides in our foods, and over-consumption of painkillers and other medical drugs are far too common in today's world. In excess, toxins can overwork your liver. When your liver is weak, instead of purifying the pollutants that enter your body, it sends them into your bloodstream. When this happens, it can make you feel overly tired and sick. A sluggish liver can also lead to allergies, bad skin, mood swings, weight gain, and even obesity.
Mother Nature, as always, provides us with safe remedies in the form of foods and herbs that can help nourish, detoxify, and strengthen our livers. Here are a few healthy ways to make your liver sing. Remember too that regular gentle exercise such as hatha yoga, walking, and swimming will help you assimilate these nutrients and assist with the detoxification process.
Beets have such a vibrant bright red color that it's not hard to imagine they are an excellent blood purifier. Try grating them on top of salads for a colorful and crunchy topping, or make a traditional Russian beet soup called borscht, which can be served hot or cold depending on the season.
Herbs like milk thistle, which is strengthening for the liver, and dandelion, which is detoxifying, have traditionally been used as liver tonics to keep the liver's lifeline flowing and healthy. My Liver Support supplement combines these two potent herbs to gently cleanse and nourish your liver.
Bitter, leafy salad greens like arugula, endive, chicory, and dandelion mixed with regular salad greens are one of my favorite ways to end a meal. Bitter salad greens, when eaten after the main course, help your organs digest the starchier foods from the meal. They also stimulate bile flow from the liver, which helps your liver naturally cleanse itself. With an herbal vinaigrette (or, if you prefer, a creamy ranch-style dressing), bitter greens can feel very soothing and renewing to your liver.
Hot water with a little squeeze of lemon is a good way to start the day. It also helps cleanse and detoxify the liver. I recommend doing this for a few days in a row and then stopping for a few days since lemon juice in excess can be hard on the stomach.
Wai Lana's Soup of the Week: Kabocha Ginger Soup
Wai Lana's Soup of the Week: Lemony Lentil Chard Soup
Wai Lana's Juice of the Week: Power Cleanse
Wai Lana: 5 Tips for an Easy Spa Day at Home
Do you ever want to escape the stress and strain of daily life and just be pampered a little bit? You don't have to spend thousands (or even hundreds) of dollars to enjoy the relaxing, soothing atmosphere of a spa. When you're feeling tense, why not set aside a little time to soothe those jangled nerves with these simple steps for an easy spa day at home …
1. Nourish Your Body with Healthy Snacks and Juice
You don't want to be hungry or thirsty while you're trying to relax. Prepare something light, healthy, and tasty ahead of time, such as a nourishing soup, enlivening salad, or (my personal favorite) fresh juice or a smoothie. For recipe ideas, try Wai Lana's Favorite Juices or Wai Lana's Favorite Soups.
2. Relax with Music
What could be more important? Sound vibration has such a powerful effect on your physical, mental, emotional, and even spiritual well-being. Try soothing soundtracks like Wai Lana's Rest and Relax or Yoga Music of the Heart. The beautiful, uplifting music will help quickly transport your mind away from the stresses and strains of daily life.
3. Take a Scented Bath
Your sense of smell is one of the most powerful senses of your body. The right fragrance will soothe yet invigorate your nervous system, uplift your spirit, and pacify your mind. My personal favorite for relaxation is combined scents such as Wai Lana's lavender and sandalwood bath salts or bath oils. Combine the therapeutic effects of aromatherapy with the healing and soothing power of water by taking a relaxing, scented bath.
4. Soothe Your Nerves with Fragrant Massage Oil
The ancient science of Ayurveda praises the use of healing scented oils for balancing the dosha of vata (wind), which tends to be aggravated in the cooler, drier weather of autumn. Fragrant massage oil will help seal in the moisture of your skin and make you feel cozy and peaceful.
5. Pacify Your Body and Mind with Yoga Nidra
Now that you're totally relaxed and peaceful, this is the perfect time to practice the relaxation pose, Yoga Nidra. Simply lie on your back with your arms slightly away from your sides, palms up, and legs slightly apart, completely relaxed. Breathe slowly and evenly and allow any trace of tension to completely drain away from your body. Try following the guided relaxation on Wai Lana's Rest and Relax. By incorporating the physical benefits of Yoga Nidra with the healing sound vibration of Yoga Sound, you will transport your mind to a place of beauty and inspiration.


text:
Slide 1
Once a Molecular Black Box
Not long ago, a normal cell was like a molecular black box. In 1971, when Congress declared War on Cancer, scientists knew the major parts and functions of a cell, but they did not understand what was happening at the molecular level. Some fundamental questions about what makes a normal cell change into a cancer cell remained unanswered.
Slide 2
Today an Open Box
Using exciting, new advances in the technology of molecular biology, scientists have opened the molecular black box and are making discoveries today that were unthinkable just a generation ago.
Slide 3
Enter CGAP: NCI's Program To Study Molecular Changes in Cancer
Scientists know that cancer arises when a cell undergoes several molecular changes. These changes take place over many years, and only when the cell has accumulated a critical number of these changes does it become a "cancer" cell.
In 1996, the Cancer Genome Anatomy Project (CGAP) began. This program of the National Cancer Institute (NCI) is studying the molecular changes that occur when a normal cell is transformed into a cancer cell.
Slide 4
CGAP Studies Genomes
CGAP studies the molecular changes in genomes. A genome can simply be thought of as the complete set of instructions for making an organism. Each organism has its own unique genome. In a human cell, the genome is found in the nucleus. A human genome has 22 pairs of chromosomes and a pair of sex chromosomes.
Slide 5
DNA Molecules: The Building Blocks of the Genome
A genome is made up of DNA molecules that contain only four chemical bases: Adenine, Thymine, Cytosine, and Guanine--called A, T, G, and C, for short. Each DNA molecule, also known as a chromosome, is made up of two related strands. Since A only likes to match up with T, and C only with G, the order on one strand dictates the order on the other. This is called base pairing and enables the genome to make copies of itself.
The order of the bases spells out a code that will be used to make the organism.
Slide 6
Genes: Functional Regions Within DNA Molecules
Genes are functional regions within the DNA molecules, and their mission is to code the instructions to make specific proteins. The human genome is thought to have approximately 25,000 genes spread across all 23 pairs of human chromosomes.
Slide 7
Genes "Switch On"
When a gene "switches on," it eventually makes a protein, but it does not do so directly. First the gene codes an intermediary molecule called mRNA. To transfer a gene's information from DNA to mRNA, base pairing is used. However, there is one change: an adenine base (A) in the DNA matches with a new base called uracil (U) in the mRNA. This difference helps to distinguish mRNA from DNA.
Slide 8
Gene to mRNA to Protein
mRNA travels from the nucleus into the cytoplasm to cell organelles called ribosomes. There it directs the assembly of amino acids that fold into a unique protein.
Slide 9
Cancer - Genes With Design Problems
In normal tissues, the genes have no design problems, but in cancer, changes occur in the DNA. Some of the genes, and hence the proteins, are not made correctly. For example, a protein may be missing, overproduced, shortened, or assembled with alterations.
Such alterations can eventually contribute to uncontrolled growth and cancer.
Slide 10
Expression Profiles
In any type of tissue, only a limited set of the genes are switched on at any given time. Also, from one tissue type to another, the limited set of genes involved will vary. Thus, each tissue can be identified by its unique pattern of gene expression. This pattern is often called an "expression profile" or a "molecular signature".
Here is an example of a normal breast cell and a normal prostate cell. Although both of these cells have many mRNAs and proteins in common (grey), they also have unique differences.
Slide 11
Expression Profiles in Cancer
It is possible to measure differences between a normal and a cancer tissue of the same type--for example, normal and cancerous prostate. Samples of normal prostate tissue will have identical expression profiles. But when a normal prostate tissue is transformed into cancerous prostate tissue, the expression profile changes.
Any changes in gene expression ultimately cause alterations in protein production. New expression profiles in a cancer cell can dramatically alter the network of proteins that interact. A critical protein may no longer be available, another may be overproduced, yet another may be flawed. And when new genes become activated, entirely new proteins may be introduced.
Many different combinations of gene changes and protein interactions are seen in cancerous tissue.
Slide 12
Measuring Expression Profiles: Step 1. Isolating the mRNA
There are two different ways to capture expression profiles, by measuring either the mRNA or the protein molecules. CGAP measures the mRNA molecules.
First, the mRNA molecules must be separated from all the other cellular molecules. Each mRNA has a unique label attached at one end, a short length of A bases (polyA) strung one after the other. Scientists take clever advantage of this feature. They create a stationary support holding short chains of polyT bases. As the cell's content passes over the support, the polyA ends of the mRNAs base pair with the chains of polyT. This isolates the mRNAs.
Unfortunately, the mRNA molecules are not very stable and may be present in very small amounts. So, having captured the mRNAs, scientists quickly convert them into something more stable and easily measured.
Slide 13
Measuring Expression Profiles: Step 2. Converting mRNA into cDNA
The next step is to convert the mRNA back into a DNA molecule in the test tube. This can be thought of simply as reversing what went on in the cell when the gene DNA was switched on and mRNA was made by base pairing.
This is a two-stage process. First, each mRNA is copied into a new DNA strand using base pairing to form a mRNA-DNA duplex. Next, the mRNA is chopped up and removed, and the DNA strand is used to make a second DNA strand. This double-stranded DNA is called complementary DNA or cDNA.
Thus, each cDNA in the test tube originally came from a specific mRNA in the cell.
Slide 14
Measuring Expression Profiles: Step 3. Converting the cDNA into a cDNA Library
At this stage there are lots of cDNA molecules in the test tube. The goal is to count how many different types there are and how many of each type are present.
To do this, scientists use E. coli bacteria. Each bacterium contains a small circular piece of DNA called a plasmid. Scientists are able to insert a single cDNA molecule into each plasmid. This solution of E. coli, in which every bacterium has one cDNA molecule per plasmid is called a "cDNA library".
Slide 15
Measuring Expression Profiles: Step 4. Isolating Each Bacterium
Each E. coli is isolated from the others and placed in a tiny test tube of its own. It is allowed to divide many times, making identical copies of itself and the inserted DNA. These identical copies are called "clones."
Slide 16
Measuring Expression Profiles: Step 5. Identifying the Clones
The final step in the process of capturing an expression profile is to identify the cDNA molecule in each clone. This is done by determining the order of, or sequencing, the bases in the cDNA. Fortunately, rather than sequence every base, scientists need only sequence about 400 bases at the polyA end to uniquely identify the entire cDNA. This short sequence is called an "expressed sequence tag" or EST, and its sequence information is stored in a public database for everyone to use.
Slide 17
Active Gene to EST
In summary, the EST represents the switched-on gene and its mRNA that was originally present in the cell.
By measuring all the ESTs, scientists can tell which genes were switched on in the cells of the original tissue, either normal or cancerous.
Slide 18
CGAP Helps Cancer Research in the Lab: Gene Analysis and Gene Discovery
CGAP has become the largest contributor of sequences to the EST database, all of which are made available to the public at no cost. In addition, CGAP has developed valuable informatics tools that help researchers to analyze this vast amount of complex data.
Using the EST database and CGAP analysis tools, scientists can find information about a particular gene in a few moments, in contrast to a few years ago, when it would have taken many hours of tedious lab work. CGAP EST data also has allowed scientists to discover genes never before seen.
Slide 19
CGAP Helps Cancer Research in the Lab: Understanding More About Cancer Biology I
CGAP has helped scientists to discover much about normal and cancer cells and their differences in a very short time.
Slide 23
CGAP Helps Cancer Research in the Clinic: Understanding More About Cancer Biology
Researchers use cDNAs to build microarrays.
A microarray consists of a glass slide onto which a large variety of cDNAs are placed in separate spots. Each spot contains many copies of the same cDNA molecules.
Microarrays enable scientists to find which genes are switched on or off in a tissue. To make a prostate-specific microarray, for example, researchers select specific cDNAs from genes that are switched on in prostate tissue of all types: normal, precancerous, or cancerous.
Here is one simplified example in prostate tissue of how a normal cell might differ from a cancerous one.
Slide 24
CGAP Helps Cancer Research in the Clinic: Step 1. Microarrays in Diagnosis
In a very simplified case, two patients suspected of having prostate cancer enter the clinic. The mRNAs from each patient's prostate cells are isolated, labeled with a fluorescent dye, and allowed to base pair with the cDNAS on separate, yet identical, prostate-specific microarrays.
Slide 25
CGAP Helps Cancer Research in the Clinic: Step 2. Microarrays in Diagnosis
When an mRNA molecule finds a cDNA that shares the same gene of origin, base pairing occurs. The fluorescent dye attached to the mRNA allows the clinician to detect and measure this binding.
Slide 26
CGAP Helps Cancer Research in the Clinic: Step 3. Microarrays in Diagnosis
By looking at the pattern of "lit up" spots on the microarray, the clinician can see which genes were originally expressed in the patients' prostate cells and make a rapid and accurate diagnosis.
Slide 27
CGAP Helps Cancer Research in the Clinic: Differentiating Between Cancers with Similar Clinical Symptoms
Microarrays have recently been used to discover that what appeared to be a single type of lymphoma was actually a mixture of two cancer subtypes at the molecular level. CGAP cancer researchers then discovered that only one subtype gave the best overall response. New treatment strategies must be developed to improve response for all subtypes of cancer.
Slide 28
CGAP Helps Scientists, Clinicians, and Patients
CGAP's use of new technologies has generated valuable information for cancer researchers worldwide, empowering the discovery of new genes and speeding up gene analysis.
These advances are providing new insights, helping clinicians to develop a molecular approach to cancer diagnosis and treatment.
The future holds great promise for cancer patients who are already beginning to benefit from these advances.


text:
Sarah's Q & A
Favorite Sport/Team
Favorite Movie/Actor
Mark Wahlburg
Go-to karaoke song
You Give Love A Bad Name
My first job
Aunt Annies Pretzels
Piercings/Tattoos (How many? Where?)
No tatts Have my nipples pierced ; )
Mac or PC?
Definitely Mac
Nintendo, Xbox 360, PS3, or don't game?
PS3 I'm not much of a gamer but like to play
What fun fact, talent or superpower of yours should guys know about?
I guess because I am shy and quite when I first meet people they are shocked that I have my nipples pierced.
What's the most memorable pick up line you've ever heard?
Does your head hurt, that must of been a long fall from heaven
What's the craziest thing you've ever done?
My husband was suppose to have his bachelor party, but due to bad weather and work schedules none of his friends could make it in. So I took him to the strip club and here is was amateur night. So I had a few shoots (for liquid courage) told him I had to go to the bathroom and snuck back stage when he wasn't looking. The look on his face when I came walking down the stage was priceless.
What's the most unusual place you've ever hooked up? How'd it go?
On vacation in a steam room. The front wall was all glass so lets just say the people walking by got one hell of a show.
What's in your purse or pocket right now?
Pocket is always my chapstick/lip gloss, purse lets not go there its a mess
What do you feel most comfortable wearing?
Booty shorts and a tank top
Would you rather have boring sex all the time or an amazing romp once a year?
Thats a tuff one. I guess boring sex because just to romp once a year that makes for really boring 364 days
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
Ben Franklin


text:
Far Cry, Prince of Persia Free DownloadsA few games for you to play over the holiday weekend, as Ubisoft has released free, full versions of four of their games. These are ad-supported though, so hopefully you dont mind seeing a few McDonalds ads. Head over to FileShack and download:
- Far Cry full game
- Rayman Raving Rabids full game
- Prince of Persia: Sands of Time full game
- Ghost Recon full game
While you are at it, you should check out the Command & Conquer Gold full game ISOs released by EA.
You must be logged in to post.


text:
Survey of Tumors Reveals Second Gene "Signature"
New research suggests that a recently discovered class of genes called microRNAs could potentially be used broadly to diagnose and classify tumors, including those of unknown origin.
During the last 5 years, researchers have found more than 200 microRNAs in humans. These small molecules - about 25 units of genetic code in length - are thought to regulate the activity of genes during development and may do the same for some genes involved in cancer.
To determine whether profiling microRNA gene activity would yield useful information, researchers in Boston surveyed the activity of 217 microRNA genes in a diverse collection of human tumors. The microRNA genes were "surprisingly informative," and the researchers found signature patterns of activity associated with different tumors, they report in the June 8 Nature. Read more
Prostate Cancer Research:
A Model for Success
Men's Health Week, June 13-19, is a good time to celebrate the tremendous progress we've made against prostate cancer - the second leading cause of cancer death among men after lung cancer. Remarkably, more than 85 percent of all prostate cancer diagnoses now occur before the disease has spread. As a result, the relative 5- and 10-year survival rates for men diagnosed at this stage are 98 and 86 percent, respectively.
But a prostate cancer diagnosis offers a vexing choice for many men, because only 1 in 10 prostate cancers poses a mortal threat. In the absence of symptoms, prostate-specific antigen (PSA) levels and biopsy results yield limited information about how aggressive the disease is. As a result, for many men, whether to undergo treatments such as surgical removal of the entire prostate, radiation, or engage in watchful waiting, is disturbingly ambiguous. Read more
Survey of Tumors Reveals Second Gene "Signature"
New research suggests that a recently discovered class of genes called microRNAs could potentially be used broadly to diagnose and classify tumors, including those of unknown origin.
During the last 5 years, researchers have found more than 200 microRNAs in humans. These small molecules - about 25 units of genetic code in length - are thought to regulate the activity of genes during development and may do the same for some genes involved in cancer.
To determine whether profiling microRNA gene activity would yield useful information, researchers in Boston surveyed the activity of 217 microRNA genes in a diverse collection of human tumors. The microRNA genes were "surprisingly informative," and the researchers found signature patterns of activity associated with different tumors, they report in the June 8 Nature.
"In terms of classifying cancers, these microRNA genes appear to pack a lot of punch," says Dr. Todd Golub of the Dana-Farber Cancer Institute and the Broad Institute of Massachusetts Institute of Technology and Harvard University.
The microRNA genes were particularly useful in diagnosing tumors that no longer resembled the tissues that originally gave rise to them. In fact, just 200 microRNA genes were more informative than 16,000 conventional genes that were profiled for comparison. If a proposed Human Cancer Genome Project goes forward, Dr. Golub notes, it would make sense to include information about microRNA genes "because the profiling can be done at low cost and may be informative."
Some researchers are already using microRNA gene signatures experimentally to distinguish between patients who have very different forms of the same cancer. "We have a microRNA gene signature for chronic lymphocytic leukemia that tells us whether a patient will likely need aggressive treatment or not," says Dr. Carlo Croce of the Ohio State University Comprehensive Cancer Center, who is preparing a paper on the subject.
Dr. Croce and his colleagues reported last year that 50 percent of the known microRNA genes reside in chromosomal regions that are either unstable or associated with cancer. The challenge now is to identify the genes that are regulated by microRNAs - and to figure out how microRNA genes themselves are regulated.
Two other studies in the same issue of Nature explore these questions with regard to the gene Myc, which is implicated in many cancers and activates a cluster of microRNA genes on chromosome 13.
In one study, led by Dr. Gregory Hannon of Cold Spring Harbor Laboratory, this cluster of microRNAs accelerated the growth of tumors when transplanted into mice with overactive Myc genes. In the other study, two microRNAs from the same cluster were shown to alter levels of a protein called E2F1 that interacts with Myc. "We have just begun to scratch the surface," says Dr. Joshua Mendell of Johns Hopkins University School of Medicine, who led the E2F1 research. "Hundreds of genes are probably regulated by this cluster of microRNAs, and we need to characterize those relationships."
One such relationship involves the cancer-promoting gene RAS and a microRNA called let-7 that was recently found to regulate RAS. As it turns out, some lung tumors are missing let-7 and this loss may allow RAS to be overactive, researchers from Yale University reported in March. "We believe let-7 is a tumor suppressor gene in lung cancer, and that the loss of let-7 in some people contributes to the cancer," says Dr. Frank Slack, who led the study.
Dr. Slack predicts that more than 1,000 human microRNAs will eventually be found. "This is turning out to be a large class of molecules, and people are starting to appreciate them for the important regulators that they are," he says.
By Edward R. Winstead
Prostate Cancer Research:
A Model for Success
Men's Health Week, June 13-19, is a good time to celebrate the tremendous progress we've made against prostate cancer - the second leading cause of cancer death among men after lung cancer. Remarkably, more than 85 percent of all prostate cancer diagnoses now occur before the disease has spread. As a result, the relative 5- and 10-year survival rates for men diagnosed at this stage are 98 and 86 percent, respectively.
But a prostate cancer diagnosis offers a vexing choice for many men, because only 1 in 10 prostate cancers poses a mortal threat. In the absence of symptoms, prostate-specific antigen (PSA) levels and biopsy results yield limited information about how aggressive the disease is. As a result, for many men, whether to undergo treatments such as surgical removal of the entire prostate, radiation, or engage in watchful waiting, is disturbingly ambiguous.
As a prostate cancer survivor and urologic oncologist, I have been greatly encouraged by the research being done to help patients and clinicians make more informed decisions. In most cancers, we are endeavoring to identify biomarkers that will signal the early presence of the disease, but prostate cancer presents the challenge of developing markers that will define the virulence of the disease.
In a study of 400 men with prostate cancer published this month in Cancer Epidemiology, Biomarkers, and Prevention, researchers from the NCI Specialized Program of Research Excellence (SPORE) at Dana-Farber Cancer Institute in Boston showed that low levels of a specific protein, AMACR, may be a powerful biomarker for aggressive disease and may yield some specific data. A 1,300-patient confirmatory study conducted in conjunction with Swedish researchers is already underway.
For those with cancer, numerous treatment advances have been made. Prostate cancer surgery can now be performed less invasively with laparoscopic techniques, and a number of facilities now offer robotic laparoscopic surgery, which may provide additional safety advantages. Radiation therapy also has improved, with new technologies allowing for more precisely targeted radiation, resulting in lower radiation doses.
And potentially new treatments may come in the form of vaccine therapy. Encouraging results have been reported in early clinical trials with a recombinant viral vector-based vaccine containing the genes for PSA and three immunostimulatory molecules developed by NCI. A cooperative group phase III trial is in the late planning stages that would test the vaccine in asymptomatic patients who have been treated with hormone therapy and whose only evidence of prostate cancer is a rising PSA. The trial may be launched later this year.
Prostate cancer research offers a model of how we're attacking cancer in the 21st century: conducting well-designed clinical trials and combining our expanded understanding of this disease's molecular underpinnings with the advantages offered by advanced technologies to improve our diagnostic, prognostic, and treatment armamentarium. We've made tremendous inroads against prostate cancer, and I have high expectations of many more to come.
Dr. Andrew C. von Eschenbach
Testicular Cancer Update: Building on Success
It's hard to find a more potent symbol of victory over cancer than world champion cyclist Lance Armstrong as he gears up for his final Tour de France race next month. Through his recovery from testicular cancer in 1996 - and his incredible athletic achievement on the Tour - Armstrong has given hope and determination to countless cancer patients, clinicians, and researchers.
Equally incredible are the tremendous strides in treatment of testicular cancer, the most common cancer to strike young men between 15 and 35 years of age, which was uniformly fatal. In recent years the rate of cure for early-stage disease approaches 95 percent. Key to that dramatic turnaround was the introduction during the 1970s of cisplatin (Platinol) into standard treatment regimens, through the pioneering work of Dr. Lawrence Einhorn and his colleagues at the Indiana University Cancer Center. Armstrong received his successful cancer treatment from Dr. Einhorn.
"The chemotherapy treatment for this disease is so successful, it's almost a miracle," notes Dr. Marston Linehan, chief of NCI's Urologic Oncology Branch.
Dr. Einhorn and others have also developed and refined highly effective surgical techniques, which, in many cases, are able to cure the disease without chemo or radiation. These include orchiectomy (surgery to remove one or both testicles) and removal of lymph nodes in the abdomen, called retroperitoneal lymph node dissection or RPLND. (The lymph nodes act as the primary route for metastases in testicular cancer.)
Despite these huge successes, researchers and clinicians are seeking further improvements in treating testicular cancer, including finding ways to minimize long-term side effects of the treatments themselves.
At last year's annual meeting of the American Society of Clinical Oncology, Dr. Timothy Oliver of St. Bartholomew's Hospital in London presented findings from 1,400 patients showing that after 4 years of follow-up, one course of carboplatin medication appeared as effective as radiation therapy in treating early seminoma - a common form of testicular cancer. Most important, the drug also appeared to reduce the risk of second cancers, compared with radiation.
"There are also some interesting questions being developed about the potential role of minimally invasive surgical approaches to treatment of testicular cancer," Dr. Linehan says.
For example, attention is being focused on whether laparoscopic surgery for RPLND is as effective as the current "open" surgery approach. Dr. Joel Sheinfeld, vice chairman of Urology at Memorial Sloan-Kettering Cancer Center, observes that this new approach remains subject to debate: "It's unclear what is the therapeutic efficacy of laparoscopic surgery as compared with open RPLND, where the therapeutic efficacy is well established," he says.
Memorial Sloan-Kettering plans to initiate a study of the less invasive RPLND technique, Dr. Sheinfeld continues. "We're going to do a study of the laparoscopic operation so that it exactly mimics the open operation. This will be for patients with low-stage, seminoma stem cell tumors. Patients with low-volume disease will not get chemotherapy."
Dr. Sheinfeld and colleagues also recently published a study in the Journal of Clinical Oncology assessing the impact of Memorial Sloan-Kettering's stringent selection guidelines for RPLND candidates. "We've learned over the years to exclude from surgery certain patients with elevated markers after orchiectomy because the likelihood of failure is so high." Since 1999, the institution has limited the procedure to only patients with low-volume disease in the retroperitoneum who are less likely to relapse. "If you look at the old data, the relapse rates were 20 to 30 percent; now it's fewer than 10 percent," Dr. Sheinfeld adds.
NCI scientists are also studying hereditary forms of testicular cancer. This is a follow-up to the discovery of a familial testicular cancer susceptibility gene on the X-chromosome (the chromosome that men inherit from their mothers), named the Testicular Germ Cell Tumor-1 (TGCT1) gene.
Dr. Mark H. Greene, chief of the Clinical Genetics Branch, is leading the Institute's Familial Testicular Cancer study, which seeks to "find the gene or genes that cause this type of cancer to occur in families." The study seeks to enroll 750 individuals from families with a history of testicular cancer. Some of the participants will be invited to the NIH Clinical Center for more detailed clinical/genetic/laboratory studies designed to identify other factors that may contribute to the development of familial testicular cancer.
NCI is also conducting a case-control study of testicular cancer among members of the U.S. Armed Forces. Dr. Katherine McGlynn, principal investigator in the Hormonal and Reproductive Epidemiology Branch of DCEG, is investigating environmental and genetic determinants of risk among approximately 800 testicular cancer cases and 800 controls, along with information from approximately 1,000 mothers of study participants.
"It is hoped that by increasing knowledge about the causes of testicular cancer, prevention and surveillance strategies will be developed which will be beneficial to future families with an increased risk of developing this cancer," Dr. Greene comments. For more information on NCI's clinical genetics testicular cancer study, go to http://familial-testicular-cancer.cancer.gov/index.html.
By Bill Robinson
Overall, long-term survival rates for men who underwent radical prostatectomy for prostate cancer were superior to survival rates among prostate cancer patients who engaged in "watchful waiting," according to a study published in the May 12 New England Journal of Medicine.
After a median of 8.2 years follow-up of 695 men, 10-year estimates show the surgery to be superior in all endpoints investigated, according to researchers led by Dr. Anna Bill-Axelson of Sweden's Uppsala University Hospital. Within the two study arms, the difference in overall survival was significant: 106 of the 348 men in the watchful waiting arm died of all causes, compared with 83 of the 347 men in the surgery arm, the researchers report.
In addition, among the surgery group, death due to prostate cancer was reduced by 44 percent compared with the watchful waiting group. Similarly, in the surgery group, the risk of distant metastasis decreased by 40 percent and the risk of local progression decreased by 67 percent. Preliminary data reported in 2002 indicated advantages for the surgical group. The authors predict "that the benefits of this surgery will increase during longer periods of follow-up."
The men in the study were newly diagnosed with prostate cancer between 1989 and 1999. Their tumors were generally more advanced than would be found in men newly diagnosed in the United States, where watchful waiting is more often recommended.
Bone Pain and Radiation: 1 Dose Equals 10
A single dose of radiation alleviates bone pain as well as 10 multiple doses over 2 weeks, with fewer adverse effects, concludes a study in the June 1 Journal of the National Cancer Institute.
Many patients with breast, prostate, lung, and other solid tumors develop metastases in the bones of the pelvis, spine, or extremities, which can cause excruciating pain. For decades, many of these patients have received a standard radiation regimen: a 3-gray dose of radiation is delivered to the painful bones in 10 treatment sessions over 2 weeks. Some 50 to 80 percent of patients report significant pain reduction with this regimen.
To help resolve a long-running debate over the time- and cost-effectiveness of this regimen, Dr. William Hartsell and colleagues at the Lutheran General Cancer Care Center in Park Ridge, Ill., recruited 900 patients with breast or prostate cancer and 1 to 3 sites of painful bone metastases. Half received the standard 10-day regimen while the other half received a single 8-gray dose.
Three months after treatment, two-thirds of patients in each group reported significant pain relief, including 15 percent in the single-dose group and 18 percent in the 10-dose group that reported complete pain relief. A third of the patients in each group no longer required narcotics. While the single-dose group returned for retreatment more often, they reported fewer adverse side effects such as nausea.
The work of Dr. Hartsell and colleagues parallels findings from two recent large trials, the Dutch Bone Metastasis Study and the Bone Pain Trial Working Party Study.
While the 10-session schedule is most common in the United States, radiologists in Great Britain are inclined to use the single 8-gray regimen, write Drs. Lisa Kachnic and Lawrence Berk in an accompanying editorial. They encouraged U.S. radiologists to adopt the single-session regimen.
Working Groups Discuss Graft-Versus-Host Disease
Researchers studying chronic graft-versus-host disease (GvHD) met on June 6 in Bethesda, Md., to share information and recommendations related to developing future clinical trials for the disease.
The meeting, co-chaired by Dr. Steven Pavletic of NCI's Center for Cancer Research and Dr. Georgia Vogelsang of the Johns Hopkins School of Medicine, marked the first anniversary of the NIH Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-Versus-Host Disease. The project aims to develop definitions and tools for conducting clinical trials, outline standards of clinical care, and guide future research.
At the meeting, six working groups reported findings from investigations into the design of clinical trials, diagnosis and staging, biomarkers, histopathology, response criteria, and ancillary therapy and supportive care. One of the main topics of discussion was the critical need to establish a common language for communicating about chronic GvHD and to develop standards for diagnosing and evaluating the disease in patients.
GvHD is a devastating disease that can occur following bone marrow transplantation if the donor's immune cells in the transplanted marrow mount an attack against the patient's tissues and vital organs. About 6,000 cancer patients in the United States are treated by allogeneic hematopoietic stem cells each year, and chronic GvHD is reported in about half of them.
The project is scheduled to publish the final findings and recommendation of the working groups starting in the fall. "In just 1 year we have laid the foundation for a new cycle of research in chronic GvHD," said Dr. Pavletic at the meeting.
Pooled Data Suggest that Alcohol Reduces Risk of non-Hodgkins Lymphoma
By pooling the original results of 9 studies involving more than 15,000 people, researchers found that participants who drank alcohol had a lower risk of developing non-Hodgkins lymphoma (NHL) compared with nondrinkers.
The overall reduction in risk was modest - about 25 percent - for current drinkers, and the source of the reduced risk is not yet clear, the researchers say. It might be due to drinking alcohol or it might be due to other lifestyle factors that distinguish drinkers from nondrinkers.
"We found a slight and consistent lower risk in current drinkers and in people who recently quit, regardless of the type of alcohol or the amount they consumed," says Dr. Lindsay Morton, a research follow in NCI's Division of Cancer Epidemiology and Genetics (DCEG) and first author of the paper.
For unknown reasons, the greatest reduction in risk was associated with Burkitt's lymphoma, one of the many NHL subtypes that involve lymph cells.
The study, published online in the June 7 Lancet Oncology, is the second in a planned series by the International Lymphoma Epidemiology Consortium (InterLymph), which includes researchers in the United States, Europe, Canada, Australia, and Asia. Future studies will follow drinkers and nondrinkers prospectively to determine whether the result is actually a biological effect of consuming ethanol. They may also focus on genetic variants associated with the metabolism of alcohol.
"We would have an important clue about the biology of the disease if we can show that drinking alcohol is found to lower the risk of NHL," says Dr. Patricia Hartge of DCEG, the study's senior author. "The current results have no implications for people's drinking habits."
eHealth Conference Discusses Research and Evaluation Issues
At last week's "Critical Issues in eHealth Research" conference in Bethesda, Md., more than 400 participants discussed the latest behavioral research concerning the use and impact of the Internet and other new communication technologies. The 2-day conference convened government scientists, academic researchers from a variety of disciplines, survey research scientists and practitioners from the private and public sectors, and students to discuss the state of the science of eHealth research theory, design, methodology, ethics, and evaluation.
Organizers of the meeting hope to jump-start a move toward scientific coherence, said Dr. Robert Croyle, director of NCI's Division of Cancer Control and Population Sciences. "Research on the basic methods and processes that underlie communication and information processing - cognition, decision making, how to utilize the technology - is scattered across 400-odd different journals, fields, and departments, where excellent science has been done. But we think it's time to assemble the theory and methodology underlying the field." Looking for efficiencies and synergy, the National Institutes of Health (NIH) wants to help organize the field to "build on the strength of the foundational, empirical research on strategies and methodology to inform our applications and interventions," Dr. Croyle said.
The conference was sponsored by NCI, the National Institute of Mental Health, the National Institute on Drug Abuse, the National Library of Medicine, the Office of Behavioral and Social Sciences Research of the Department of Health and Human Services, the Office of Disease Prevention of NIH, and the Health e-Technologies Initiative of the Robert Wood Johnson Foundation.
Targeting Progressive Chronic Lymphocytic Leukemia
Name of the Trial
Principal Investigator
Why Is This Trial Important?
Some patients with CLL, however, develop a more rapidly progressive form of the disease that often proves resistant to standard treatment. The average survival of these individuals is less than 24 months following diagnosis.
In this study, researchers are testing the effectiveness of an immunotoxin called LMB-2 in selectively killing CLL cells. LMB-2 is a laboratory-created monoclonal antibody fragment attached to a bacterial toxin. LMB-2 binds to a protein called CD25, which is found on the surface of many human lymphocytes. CD25 is more abundant on CLL cells than on normal lymphocytes, thereby allowing malignant cells to be targeted with great specificity. Once LMB-2 binds to CD25 on the cell surface, the toxin is taken up by the lymphocytes, causing them to die.
Patients enrolled in the study will receive up to 6 courses of LMB-2 over approximately 6 months, providing their disease does not worsen. If and when patients respond completely to LMB-2 (CLL is undetected), they will be given 2 additional courses of treatment.
Who Can Join This Trial?
Where Is This Trial Taking Place?
Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
The American Stop Smoking Intervention Study for Cancer Prevention (ASSIST) was an 8-year nonrandomized demonstration project for tobacco control, conducted from 1991-1999 by NCI, the American Cancer Society, and 17 state health departments. The monograph, ASSIST: Shaping the Future of Tobacco Control, documents models and lessons learned, describes case studies on ASSIST interventions, and provides concrete examples for building long-term capacity and positive behavioral health changes by applying these policy and media approaches. It is intended for program planners, public health practitioners, researchers, advocates, and state and local health department staffs to promote positive behavioral change.
ASSIST: Shaping the Future of Tobacco Control can be ordered at www.cancer.gov/publications or by calling 1-800-4-CANCER. It is available online at http://dccps.cancer.gov/tcrb/monographs/
NCI Fellow Selected for Tour of Hope
The Tour of Hope team comprises cancer researchers, nurses, physicians, caregivers, and cancer survivors. Almost 1,200 people applied for the 3,300-mile trip from San Diego to Washington, D.C., to inspire and inform the public about the importance of cancer research and clinical trials. The Tour begins on September 29th and ends on October 8, with team members relay-riding in 100-mile segments around the clock.
NCI Reaches Out to Minority Cancer Survivors
The interview reaching the widest audience took place on Monday, June 6, on the national Spanish-language morning talk show, Despierta America (Wake Up America!). The show is the Latino community's version of the Today Show and is broadcast every weekday morning on the Univision network. NCI's Dr. Jorge Gomez, head of the Organ Systems Branch and the Special Programs of Research Excellence (SPOREs) program, was interviewed during a live 4-minute segment. Dr. Gomez appeared on the show with Carolina Hinestrosa, a two-time breast cancer survivor who is also an advocate with the National Breast Cancer Coalition and an organization called Nueva Dia (New Day), for Latina cancer patients.
Also on June 6, Dr. Harold Freeman, head of the Center to Reduce Cancer Health Disparities, taped an interview on cancer survivorship as it relates to the African American community for the American Urban Radio Networks. That interview was broadcast throughout the day as part of the network's news package. American Urban serves 475 stations and about 25 million listeners across the U.S.
NCI's Dr. J. Fernando Arena, program director in the Epidemiology and Genetics Research Program in the Division of Cancer Control and Population Sciences, kicked off the Survivors Day interviews on Saturday, June 4, with a live 15-minute segment with Dr. Elmer Huerta on the Prevenir es Salud radio show, which is heard on 44 radio stations nationwide.
Men's Group Supports Prostate Cancer Patients
At each weekly meeting of the prostate cancer patient support group in Greenbrae, Calif., group co-facilitator Stan Rosenfeld always looks for the newcomers.
The new guys are easy to recognize, he says: "Most are men who are newly diagnosed. They've got the shock of having cancer in an area of their body that a lot of guys don't know much about, which is an additional puzzlement to them." Mr. Rosenfeld and other long-time members of the group remember what it was like for them years before - the confusion, the hunger for information, and the welcome empathy from other people who had gone through the same experience.
They start each meeting by "focusing on any newcomers," he notes. "They get special treatment, including a big packet of information. We can easily spend an hour talking with one new guy," answering his questions and reviewing his pathology report and other information to hone in on his diagnosis and treatment options. "They see all these guys at the meeting, most of whom have survived many years after diagnosis and treatment," Mr. Rosenfeld adds. "That can be very encouraging."
Stan Rosenfeld joined the group in 1998 shortly after his diagnosis with prostate cancer. It was one of the first men's support groups for prostate cancer and is affiliated with the University of California, San Francisco Comprehensive Cancer Center.
"When the group got started, doctors were reluctant to send patients to support groups for fear the patients would get some advice contrary to what the physicians were offering," Mr. Rosenfeld recalls. "That's all changed. Now when a patient asks 'What do I do? How can I get more information?' the first thing doctors and their nurses will tell them is to join a support group."
Rosenfeld credits this change to the quality and up-to-date information provided by group leaders and the careful training most of them receive from the American Cancer Society's Man to Man program (www.cancer.org) and the Us Too organization for prostate cancer (www.ustoo.org).
The group Mr. Rosenfeld helps lead draws between 20 and 25 people to each meeting. They include mostly men, but the group is also open to spouses, family members, and friends. "About half of the attendees are guys who are trying to make their treatment decisions," he adds. "Often a guy has many good treatment options to choose from, including surgery, radiation, and hormone therapy. That can be very confusing. We can tell him what all of these things are actually like and help him make the best choice."
Most men continue coming to the group's meetings until their treatment is completed. Some come back if their cancer recurs. Some come back because they're committed to helping other men.
Mr. Rosenfeld adds, "I'm always very happy and pleased when guys come back to a meeting after they've had their treatments and thank the group. I've seen a few guys in tears as they expressed their gratitude for the information and support they received from the group."


text:
Plan your trip to Oceania
Select a region below to explore Resorts & Lodges in that destination.
Resorts and Lodges in Oceania
Oceania Top List Picks
Top 10 Queensland Beach Resorts
Welcome to the Sunshine State – and we're not talking Florida. No, our search for sun, surf and golden rays has taken us far from mainland America and straight into the beloved Australian region... more
Top 10 Sydney Luxury Hotels
Australia may be best known for untamed landscapes teeming with the likes of koalas, kookaburras and kangaroos. So who would have guessed that Sydney, Australia's famed Harbour City, would be the... more


text:
Collector's Editions
Pre-Order Now
An extensive array of digital and physical content, designed to prepare you for a new era of combat.
Pre-order Call of Duty®: Advanced Warfare and get access to the Advanced Arsenal, featuring a custom bullet brass themed exoskeleton and the EM1 Quantum, an all-new directed energy weapon, for use in multiplayer gameplay. Be ready for combat on day one in Call of Duty: Advanced Warfare with the Advanced Arsenal.


text:
Exterminate It!
Exterminate It! is a highly efficient and convenient antimalware program that is only activated when needed thus economizing your operating system's space not overburdening your computer with extra processes day by day. This anti spyware solution features a long list of advantages and bonuses.
Full features list and screenshots
Adware BHO Backdoor Dialer DoS Downloader Hacker Tool Hijacker Hoax Hostile Code
Malware Popups RAT Ransomware Rootkit Spyware Toolbar Tracking Cookie Trojan Virus Worm
2009 © Adware Removal.us


text:
You are visiting our UK site. Click here to view our US site
Il Hwa Korean Ginseng Capsules 500mg x 100 (HWA021)
Each capsule contains 500mg of fine ginseng powder. Each box contains 100 capsules.
Directions of use:
Take two or more capsules with water when desired.
Weight (including packaging): 250g
4 in stock
Now: £21.99 (zero tax)
Was: £25.54
Save: £3.55
Saved: 13.90%!
Save: £3.55
Saved: 13.90%!
Customer Reviews
There are currently no reviews for this product. Be the first!Review this product...
Subscribe To CMT
Shopping Basket
Your basket is empty!
Change Language
Change Currency
Events Calendar
Korean Hand Therapy with Jong Baik in London 04/09/2014-09/09/2014
Korean Hand Therapy (KHT) is unique when compared to other hand reflexology... [more]
Master Tung Acupuncture Parts 1&2 with Philip Weeks - Novemeber 7th/8th
A very practical 2 day workshop with lots of practise!. Tung Acupuncture is well known for its quick and spontaneous results... [more]


text:
Its been 31 years since William Shatner first screamed "KHHHHHHHAAAAANNNNN" in movie theaters across the country. Star Trek II: The Wrath of Khan premiered on June 4, 1982. The current popularity of J.J. Abrams' Star Trek Into Darkness is a tribute to the impact and longevity of Nicholas Meyer's original film.
Here's a quick trip down Wrath of Khan's Memory Lane...
Wrath of Khan Theatrical Trailer
Wrath of Khan TV commercials
Wrath of Khan on ABC's Sunday Night Movie (1985 )
Wrath of Khan Blu-Ray Trailer (AWESOME!)
Wrath of Khan meets Monty Python
Photo credits: Official Paramount movie posters for Star Trek II: The Wrath of Khan
Greg Belfrage is an avid Star Trek fan, serious Batman toy collector and hopeless geek. He hosts the morning show on KELO Newstalk 1320 AM / 107.9 FM.


text:
Hong Kong Monetary Authority Investment Portfolio
|Hong Kong (China)
|US$ 326.7 Billion
|Established: 1993
Transparency Rating: 8
View Sovereign Fund Transaction Data
View Asset Allocation
|Origin: Non-Commodity
Firm Investment Style: Mixed
Entity Structure: Fund
Pop Est.: 7.18 million – 2013 HK
Wealth Per Capita Est.: $45,495
Part 1: Backing Portfolio
Part 2: Investment Portfolio
Part 3: Strategic Portfolio
|Strategy & Objectives
Main Office
Other Offices[ Content protected for Sovereign Wealth Fund Institute Standard subscribers only. Please subscribe to view content. ]
Sovereign Wealth Enterprises
Real Gate Investment Company
Real Gate Investment Company (RGIC) is a wholly-owned company that has made investments into two undisclosed real estate joint venture companies. These companies are incorporated outside of Hong Kong and have themselves made overseas investments. In one of the companies, RGIC owns a 74 percent stake, the other a 51 percent stake.
Eight Finance Investment Company
Formed in 2009, Eight Finance Investment Company pursues alternative investments for the HKMA.
- Drawbridge Investment
- Debt Capital Solutions Company


text:
Black Tea Roanoke Rapids NC
Roanoke Rapids, NC
Roanoke Rapids, NC
Halifax Medical Specialists
Internal Medicine
Insurance Plans Accepted: Most insurance plans accepted. Call office about your medical plan acceptance information.
Medicare Accepted: Yes
Workmens Comp Accepted: Yes
Accepts Uninsured Patients: Yes
Emergency Care: No
Doctor Information
Primary Hospital: Halifax Medical Center
Additional Information
Member Organizations: Board Certified, American Board of Internal Medicine.
Languages Spoken: English,North Ndebele
Roanoke Rapids, NC
Family Practice
Roanoke Rapids, NC
Cardiology, Internal Medicine, Cardiovascular Disease
Roanoke Rapids, NC
Internal Medicine
Roanoke Rapids, NC
Roanoke Rapids, NC
Cardiology, Internal Medicine, Cardiovascular Disease
Roanoke Rapids, NC
Family Practice
Roanoke Rapids, NC
Internal Medicine, Pulmonary Disease, Critical Care (Intensivists)
Roanoke Rapids, NC
Cardiology, Internal Medicine, Cardiovascular Disease
Heal Thyself - Spotlight on Immunity
By Julia Van Tine
If you're reading this now, in midwinter, chances are your most immediate need is to find ways to ease the burden of the season's colds and flus. This year's shortage of flu vaccine, which raises everyone's risk of getting sick, only makes the task more urgent.
But there are plenty of other reasons to pay attention to your immune system. It does much more than protect you from the occasional cold or virus—it's the backbone of your defense against a world of invisible perils. When it's healthy, its T cells, B cells, and natural killer cells work quickly, decisively, and in harmony to ambush rogue microorganisms, environmental toxins, and cells gone awry. You might liken its workings to expert dancers who can anticipate their partners' every move. All of them are supported by other cells, tissues, and organs that search out and destroy marauding microbes.
And the payoff for tending to your immune system on a daily basis, giving it the same care and consideration you give, say, a beloved pet, is considerable. You can lessen the risk of all sorts of ailments: environmental allergies, asthma, autoimmune diseases like rheumatoid arthritis, and even cancer.
What's the best way to bolster this protective armor? You already know about giving your immune system the basics it requires to function: a diet rich in vegetables, fruits, and whole grains; adequate rest and exercise; and a stress level that doesn't get out of hand.
But these days, supplement aisles are packed with products that claim to boost your immunity even further. Some really deliver, and some don't. Here are the ones that can keep you healthy—not just during the cold season, but all year round. All have a good track record, so you can pretty much pick the one or ones that appeal to you. (The more the merrier.)
• Fight flu with elderberry
In the 18th century, Europeans drank hot wine made from the berries of the elderberry tree to ease cold and flu symptoms. Modern herbalists still recommend elderberry for viral infections, especially the flu.
"The extract inhibits replication of several strains of influenza A and B," says Oklahoma City physician Larry Altshuler, author of Balanced Healing: Combining Modern Medicine with Safe and Effective Therapies. In a study of 60
Norwegian men and women with early-stage flu, those who got elderberry extract recovered more quickly and used less medicine than those who took a placebo extract. User's tip: While elderberry is available in various forms, Altshuler says the best research has been done on the syrup. Follow label directions.
• Sip a soothing cuppa
Tea drinkers rejoice: Your favorite beverage may help you fight off colds and flu. Harvard University researchers found that people who drank five cups of black tea a day for two weeks had stronger T cell responses to bacteria than those who drank coffee. Green, white, and red teas can also offer immune benefits.
User's tip: Can't drink five cups a day? Fewer ...
Copyright 1999-2009 Natural Solutions: Vibrant Health, Balanced Living/Alternative Medicine/InnoVisi...


text:
Ultra Facial Moisturizer Sample
Rollover to enlarge
Makes my skin feel moist again. Jan 21, 2013
It works Nov 21, 2012
Kiehl's Since 1851 Rewards earns you
points for your everyday purchases and the
chance to be a VIP.
More Kiehl's to love,
more points to earn
One Dollar Spent = One Point
Kiehl's Since 1851 Rewards
And much, much more!
Rollover to enlarge


text:
Publication: theday.com
I got this idea from my bloggy friend Suzanne, but wasn't quite sure Little Man could have handled it a few months ago. To be quite honest, I wasn't quite sure what he would say now, but we gave it a go. I think it would be fun to do this every six months or so....
Here goes nothing...
1. What is something Mommy always says to you?
No yellin'
2. What makes you happy?
You (points at Mommy)
3. What makes you sad?
The Guy
[Little Man had his first bad dream that he remembers just last night. The Guy was tiny and sitting in his bed trying to take his things and Little Man's friend Cooper was telling him No. It must have been traumatic enough to wake him up because I had a tiny person inches from my face at 1:15 this morning]
4. What makes you laugh?
You (points at Mommy)
5. How old are you?
LM: Two.
M: Are you sure?
LM: Four. Are ya three? Are ya four?
M: Buddy, you just had a birthday, how old are you?
6. How old is Mommy?
7. How old is Daddy?
Two. He's Three.
8. What is your favorite thing to do?
9. Who is your best friend?
[Points at Mommy]
[Be still my heart]
10. What do you want to be when you grow up?
You. (points at Mommy)
11. What are you really good at?
Puttin' stuff away
[I really beg to differ on this answer]
12. What are you not very good at?
This. (points at computer screen)
13. What did you do today?
LM: This right here (points at computer screen).
M: What else?
LM: Idunnknow.
14. What is your favorite food?
15. What is your favorite song?
Fresh Beats
16. What do you want for your birthday this year? [A somewhat confusing question, as his birthday was two days ago]
Ummm...Idunnknow...maybe Gigantasaurus?
[He already got Gigantasaurus, which it turns out, when I looked up the spelling of it, is not called Gigantasaurus. Its called Giganotosaurus. Good luck to me trying to tell that to Little Man]
[It is at this point in the interview that the toddler begins licking my arm]
17. What is your favorite animal?
M: Anything else?
18. What is love?
Yoouuuuuu! (points at Mommy)
19. What does Daddy do for work?
20. Where do you live?
[blankedy] Lane!
[I took the liberty of not telling you our street. But he got it right, for the record]
21. Where is your favorite place to go?
The playground.
Day Photo Staff | On Assignment
David Collins | Today, in The Day
Karen Florin | On The Docket
Day staff | Taste Buds (Dining)
Jenna Cho | Salt to Taste
Jill Blanchette | Healthy Cooking
Kristina Dorsey | Reel Life
Marisa Nadolny | Pop Blog
Rick Koster | Aging Rock Dude
Sunday Night TV | Mad Men Monday
Just Listen | The Day's music writers share their playlists
Steve Fagin | The Great Outdoors
Vickie Fulkerson | High School Sports
Richard Cooke | Yawkey Way
Ned Griffen | High School Football
Gavin Keefe | UConn Men's Hoops
Clint L. Bramlett | The Real Mister Fantasy


text:
James C. Moore, Co-Author of Bush's Brain," The Political History of Karl Rove, explains why people would ever suspectthat this leak traces back to Rove.
Daniel Drezner's most recent post and the comments following will give you a real feel for the way the Right is struggling with this story.
Two stories by my colleagues at Open Source Politics are not to be missed. Mark A. R. Kleiman helped keep this story alive through the late summer. He provides the overview here. Lilith Devlin explains why this story is important.
Ted at Crooked Timber dissects Scott McClellan's press conference yesterday and comes to the conclusion that he doesn't really deny any involvement on the part of Rove.