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Natural Radiance—Give Your Face a Lift
By Jennifer Winger
When it comes to skin, fighting the signs of aging can feel like an uphill battle. But now those fretting over fine lines and wrinkles have another weapon in their cosmetic arsenal: hyaluronic acid (HA), a little-known molecule that can smooth and soften skin.
This gelatinous material—a component of our connective tissue—is found in almost every cell in the body, where it performs a number of functions including cushioning the joints, protecting the eyes, adding volume to the hair, and lubricating the skin. Fully 50 percent of HA resides in the skin, from the deep dermal to the visible epidermal layers. Some research has linked oral HA supplementation to a 40 percent decrease in the time it takes wounds to heal.
What makes this molecule add suppleness to skin? Its unique rope-like shape increases its surface area, allowing it to retain up to 1,000 times its weight in water. This water-binding property, some believe, makes HA a particularly potent ingredient in any skin care regimen.
In youth, our skin is toned and smooth. But as we age, among other physiological changes, the body loses its ability to maintain sufficient levels of HA. Also collagen—the main protein of connective tissue responsible for skin elasticity—becomes flaccid and weak, allowing fine lines and crow's feet to develop. Hyaluronic acid is one ingredient that may plump sagging skin and restore a dewy complexion.
"Hyaluronic acid pulls water to itself then expands and becomes like a cushion of water molecules, like gelatin," explains Anna Ragaz, MD, a holistic dermatologist and founder of the Anna Ragaz Institute for Anti-Aging in Seattle.
Hyaluronic acid comes in three kinds of products—oral supplements, topical creams, and injections. The first two are readily available on store shelves. The third requires a physician's hand and a product such as Restylane, Hylaform, or Captique, brand names for plumping alternatives to collagen injections.
How HA works is still a bit of a mystery. Researchers think instead of creating new fat to flesh out wrinkles like collagen injections, HA either penetrates deep within the skin scaffolding to moisturize and deliver nutrients to overextended collagen, or when applied topically it sits on the surface, creating a humectant barrier that encourages the skin to snag water molecules, making it appear smoother.
What medium best delivers HA to the skin? That, too, remains open to discussion. According to Ragaz, research supports HA's power as a wrinkle smoother when injected as a "filler." Others champion topical hyaluronic acid. According to Darren Landis, of Hyalogic LLC Co., a manufacturer of HA-boosted serum and lotions, using an HA serum or cream, in combination with healthy habits, can yield results in as little as two weeks.
Finally, the issue may come down to ease of use and cost. The effects of one injection treatment can last for six months and may cost between $500 and $1,000. Makers of topical prod...
Copyright 1999-2009 Natural Solutions: Vibrant Health, Balanced Living/Alternative Medicine/InnoVisi...


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Temporary worker programs and the treatment of migrant workers have gained increased international attention in recent years. In some countries, the temporary worker system acts as a transition to permanent immigration. Other countries have highly regulated temporary worker systems with no pathway to permanent immigration. The research here examines temporary worker programs, policies that bridge from temporary to permanent status, and efforts by sending-country governments to protect their workers overseas.
This book reflects the effort of the Transatlantic Council on Migration to map how profound demographic change is likely to affect the size and character of global migration flows; and how governments can shape immigration policy in a world increasingly attuned to the hunt for talent.
Report looks at E-Verify, the internet-based program operated by the Department of Homeland Security (DHS) in partnership with the Social Security Administration (SSA). The program gives employers a means to electronically verify the work eligibility of newly-hired employees.
The Middle East and Northern Africa (MENA) and Europe appear to be an ideal demographic match: the former has a large supply of young, active workers, and the latter has a shortage of the youthful, skilled or unskilled labor it needs to sustain its economic competitiveness. MENA is the source of 20 million first-generation migrants, half of them now living in another MENA country and most of the rest in Europe. The region also hosts around the same number within its borders. In addition, the size of MENA's working-age population will continue to rise sharply in the next two decades while the corresponding segment of the population in Europe will soon start to decline.
This exploratory study provides an unprecedented assessment of the "brain-waste" phenomenon in the United States—a serious waste of human capital resulting from the unemployment or underemployment of highly skilled college-educated immigrants.
This brief offers an analysis of the Philippine Overseas Employment Administration, the Philippines' highly successful system of managing the overseas employment of temporary Filipino workers. The report examines the structure and mechanism of the system, identifies key areas of improvement, and offers policy recommendations for addressing existing flaws.
This report investigates how migrant-sending countries can protect their migrant workers abroad by examining the policies, functions, and challenges of the Philippine government's membership-driven welfare fund, the Overseas Workers Welfare Administration (OWWA).
This report draws from the existing body of knowledge surrounding circular migration to identify: research gaps, shortcomings of common policy routes, innovative circular migration policies, and critical considerations for policymakers seeking to design and implement positive circular migration schemes.
For an increasing number of scholars, international migration has undergone a transformation particularly in the last decade or so. Although circular migration's impact on development is far from settled, a review of the current literature suggests increasing optimism about its developmental potential.

subset: commoncrawl


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DH and I have decided to start trying for our final chapter after our youngest DD turns 1 (Dec 28th) so 3 more months I get to join you all! I have always been a stalker but I might be in here just a little bit more. I have the fever BAD!
Welcome! You will be in here trying before you know it! Even though it does seem like forever.
Katy - 26, DH - 26, DD - 4
Make a pregnancy ticker
Well glad to see you. I knew it would not be long and you would give in to that fever. LOL
Great to hear, Rach! I'm excited for you!
Super exited for you!
Mariah (35) and DH (40) BFP 8/12/13! Baby Kayla is here! Praying for all the APA girls .
Good luck rachel
Yay! We are trying for our LAST in late Dec. too. Good luck Momma!
~*~Katrina~*~ Momma to Xander, Hayden & Lily (6) and Jericho (3 1/2)
OOO!!! I hope to hear you get your BFP before me but I would love to be in a dd room with you again!
Sammi(me)~DH(Troy)~DS(Kyle)~DD(Rebecca)My Blog


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By Alexis WileyFox 2 NewsDETROIT (WJBK) -- Kwame Kilpatrick is on trial facing federal corruption charges, but Detroit's former mayor says he's actually a crime fighter. The story came to light thanks to a tweet.Kilpatrick says he stopped a would-be burglar near his mother's home on Detroit's west side.Chris Thompson lives nearby."We haven't seen anything or heard anything about break-ins around here lately."He would have heard about one if he followed Kilpatrick on Twitter. Wednesday night, Kilpatrick tweeted, "Dude breaking into a house on Moms street. I yelled 'Hey get out of there.' He said 'Damn, Ok Kwame.' Then asked me for a picture. Wow!"When asked whether he called the police, Kilpatrick tweeted, "No way. The police would book me for sure."I couldn't find anyone on the block who actually saw it or heard any commotion Wednesday, but that certainly doesn't mean it didn't happen. So while there are plenty of questions here, one thing is for sure. Kwame Kilpatrick still knows how to grab our attention, even on Twitter.
WHBQ-TV | Fox 13 485 S. Highland St.Memphis, TN 38111Main Station: (901) 320-1313Newsroom: (901) 320-1340


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SPORE Study Provides New Guidelines for Tamoxifen Use
Approximately half a million women in the United States alone currently take the drug tamoxifen, either as an adjuvant therapy for preinvasive or invasive breast cancer, or as a chemopreventive agent for those at high risk of the disease.
Now, a new study led by Dr. Matthew Goetz, an investigator for the Breast Cancer Specialized Program of Research Excellence (SPORE) at the Mayo Clinic, has shown that up to 10 percent of women taking the drug may not receive the intended benefit due to genetic differences in the way tamoxifen is metabolized. Additionally, a larger percentage of women may be at increased risk of treatment failure because of drug interactions. Read more
The Power of Numbers: Melding Genomics and Epidemiology
NCI is moving on a number of fronts to harness the power of new genomic technology through epidemiologic studies designed to uncover gene variants that contribute to cancer susceptibility. Findings from NCI's portfolio of family studies have formed the basis for our understanding of many high-penetrant cancer-causing mutations. These rare mutations give unprecedented insights into carcinogenic mechanisms, but are responsible for only a small proportion of all cancer. Most cancer risk is believed to be due to gene-environment interactions involving low-penetrant but common genetic variants or single nucleotide polymorphisms (SNPs). Read more
SPORE Study Provides New Guidelines for Tamoxifen Use
Approximately half a million women in the United States alone currently take the drug tamoxifen, either as an adjuvant therapy for preinvasive or invasive breast cancer, or as a chemopreventive agent for those at high risk of the disease.
Now, a new study led by Dr. Matthew Goetz, an investigator for the Breast Cancer Specialized Program of Research Excellence (SPORE) at the Mayo Clinic, has shown that up to 10 percent of women taking the drug may not receive the intended benefit due to genetic differences in the way tamoxifen is metabolized. Additionally, a larger percentage of women may be at increased risk of treatment failure because of drug interactions.
Both genetic polymorphisms and many commonly administered drugs - such as selective serotonin reuptake inhibitors - can affect the activity of an enzyme called cytochrome (CYP) 2D6. Dr. David Flockhart's group, which is funded by the National Institute of General Medical Science's Pharmacogenetics Research Network, has performed extensive basic science work and early clinical studies demonstrating that CYP2D6 activates tamoxifen, producing a molecule called endoxifen, which is thought to be the metabolite primarily responsible for tamoxifen's therapeutic effect.
"Basic science has told us for the past 30 years that this enzyme is genetically polymorphic, and we expected people with the polymorphisms to make about five times less of the active metabolite," explained Dr. Flockhart, chief of the Division of Clinical Pharmacology at Indiana University and a collaborator on the SPORE project.
The SPORE data used to test this hypothesis came from a prospective randomized trial conducted by the North Central Cancer Treatment Group, in which postmenopausal women were administered 5 years of tamoxifen therapy for estrogen-receptor-positive breast cancer. Both CYP2D6 genotype and medications that interfere with CYP2D6 were known for 180 women randomly assigned to the tamoxifen-only control arm of the trial.
Researchers classified 65 of these women as having decreased metabolism of tamoxifen based on expected genetic or drug-induced inhibition of CYP2D6. The SPORE investigators then compared time to breast cancer recurrence, disease-free survival, and overall survival between those with decreased CYP2D6 metabolism and the 115 patients expected to metabolize tamoxifen normally.
The clinical benefit of tamoxifen was greatly decreased for women with factors that negatively affected CYP2D6 metabolism. These women had significantly shorter time to disease recurrence and significantly worse disease-free survival compared with women able to metabolize the drug normally. Women with the largest decrease in CYP2D6 metabolism (CYP2D6 poor metabolizers or those taking a potent CYP2D6 inhibitor) had a threefold higher risk of breast cancer recurrence while taking tamoxifen. The final results from this study, which was also funded by a K-12 training grant to Dr. Goetz, were published online November 18 in Breast Cancer Research and Treatment.
On October 18, a presentation of this study and related historical data by Dr. Goetz to the Food and Drug Administration led to an advisory committee unanimously recommending a label change for tamoxifen. This change would include information about the increased risk both from genetic factors and drug interactions affecting CYP2D6. The majority of the committee also recommended that the label mention CYP2D6 genotype testing as an option for women before they are prescribed tamoxifen.
"The promise of pharmacogenetics is the ability to individualize therapy for our patients," said Dr. Goetz. "In the case of tamoxifen, CYP2D6 may be a marker which identifies patients who can be successfully treated with sequential tamoxifen followed by an aromatase inhibitor or who should be treated up front with an aromatase inhibitor."However, he explained, prospective clinical trials are needed to identify whether selecting breast cancer patients for tamoxifen therapy based on genetic variability in CYP2D6 will lead to superior clinical outcomes.
By Sharon Reynolds
The Power of Numbers: Melding Genomics and Epidemiology
NCI is moving on a number of fronts to harness the power of new genomic technology through epidemiologic studies designed to uncover gene variants that contribute to cancer susceptibility. Findings from NCI's portfolio of family studies have formed the basis for our understanding of many high-penetrant cancer-causing mutations. These rare mutations give unprecedented insights into carcinogenic mechanisms, but are responsible for only a small proportion of all cancer. Most cancer risk is believed to be due to gene-environment interactions involving low-penetrant but common genetic variants or single nucleotide polymorphisms (SNPs).
As outlined at last week's meeting of the National Cancer Advisory Board, some of the most promising of these studies of susceptibility genes are being led by investigators in NCI's Division of Cancer Epidemiology and Genetics (DCEG). Together with colleagues in the Division of Cancer Control and Population Sciences (DCCPS) and Office of Cancer Genomics, they have joined forces with extramural collaborators to form strategic partnerships that link epidemiologists, genomicists, and other investigators from the clinical, basic, and population sciences. This transdisciplinary team-based approach responds to a growing consensus in the scientific community that realizing the full potential of genomic and other new technologies requires their integration into robust, large-scale epidemiologic studies.
This can be accomplished through consortia that combine resources of several large cohort and/or case-control studies in a coordinated approach that allows rapid replication of positive findings. One such unique partnership is the Cohort Consortium, an international collaboration of intramural and extramural investigators responsible for 23 population cohorts encompassing 1.2 million individuals. The Cohort Consortium provides an integrative framework for nested case-control studies of specific cancers arising within the cohorts to systematically evaluate molecular and biochemical biomarkers of susceptibility and disease.
DCEG investigators are attempting to identify cancer susceptibility genes using the pathway-driven approach and genome-wide association studies (GWAS). The former approach involves studies that investigate risks associated with candidate genes selected on the basis of known function or biologic plausibility. For example, in a case-control study conducted in Spain and published last year in Lancet, DCEG's Dr. Montserrat Garcia-Closas and colleagues at NCI and in Spain showed that SNPs in two candidate genes, NAT2 and GSTM1, were associated with increased risk of bladder cancer and modified the risk due to cigarette smoking. Although the relative risks were modest, these SNPs are common among bladder cancer patients and may contribute to nearly one-third of the cases.
In contrast, GWAS use the latest technologies to "interrogate" the entire genome without targeting any specific gene. Led by a team of DCEG and extramural epidemiologists, statisticians, and genomicists, the Cancer Genetic Markers of Susceptibility (CGEMS) project is using high-throughput technology to identify and validate susceptibility genes for breast and prostate cancer. The potential associations identified will be validated in subsequent studies to eliminate false-positives due to chance. To date, GWAS have been completed on 1,200 prostate cancer cases and controls, and the data have been made available on NCI's cancer Biomedical Informatics Grid™ (caBIG™). It is anticipated that the initial scan for breast cancer will be posted in early 2007, and plans are underway to launch a similar scan for pancreatic cancer.We believe that these highly collaborative strategies currently will provide the scientific community with unprecedented opportunities to understand cancer susceptibility mechanisms, including gene-environment interactions, and thus inform new strategies to accelerate the prevention, early detection, and treatment of cancer.
Dr. John E. Niederhuber
Drug Prevents Mammary Tumors in Mice by Reducing Progesterone Activity
Researchers have found that inhibiting the activity of the hormone progesterone can prevent the development of mammary tumors in mice that carry mutations in a rodent version of the human breast cancer gene BRCA1. Mutant mice treated with the drug RU486, the "morning after" pill (also known as mifepristone and Mifeprex), did not develop mammary tumors by the time they were a year old, while the untreated mice developed tumors by 8 months of age.
Women who inherit BRCA1 gene mutations are at an increased risk of breast and ovarian cancers, and many reduce their risk by having their ovaries or breasts surgically removed. Though the new research was done in mice, the findings raise the possibility that inhibiting progesterone might be an additional strategy for reducing the breast cancer risk among these women.
High progesterone levels have been linked to an increased risk of breast cancer, and this study suggests a mechanism. Dr. Eva Lee of the University of California, Irvine, and her colleagues propose that the normal BRCA1 protein may help protect against breast cancer by helping to degrade the receptor protein that binds to progesterone.
If the progesterone receptor is not broken down, then the hormone's growth-promoting signal persists, and this may lead to excessive cell growth and cancer, the researchers reported in the December 1 Science. To reduce the hormone's signal, they tested mifepristone, which inhibits the progesterone receptor, and found that it prevented mammary tumors from developing.
The results suggest that the progesterone receptor function may be critical to the development of breast cancer in the presence of BRCA1 mutations. "These findings reveal a tissue-specific function for the BRCA1 protein and raise the possibility that antiprogesterone treatment may be useful for cancer prevention in individuals with BRCA1 mutations," the researchers concluded.
Previous research has suggested that the normal BRCA1 protein suppresses tumors by repairing damaged DNA before tumors develop, and the regulation of the progesterone receptor levels would be another role for the protein.
Dr. Lee noted that mifepristone has effects on other hormones in addition to progesterone and therefore might not be ideal for long-term use in cancer prevention among women with BRCA1 mutations. Other progesterone-blocking drugs are in development and may be suitable.
Bacteria, Chemo Combination Shows Potency in Mouse Model
A protein produced by a genetically modified bacterium appears to enhance the tumor-killing ability of common chemotherapy drugs that are encased in fatty capsules called liposomes. Because liposome-encapsulated drugs stay in the body longer, they can more selectively target tumors.
In a study published in the November 24 Science, researchers from the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University showed that combination therapy involving the bacterium C. novyi-NT and Doxil, which is the liposome-encapsulated version of the chemotherapy drug doxorubicin, in a mouse model of colorectal cancer caused a complete disappearance of tumors in all of the mice tested; two-thirds of the mice survived for more than 3 months. Similar results were seen using a liposome-encapsulated version of the chemotherapy drug irinotecan. There was generally no evidence of toxicity from the treatment.
The same research team, from the lab of Dr. Bert Vogelstein and led by Dr. Ian Cheong, had previously shown that C. novyi-NT selectively kills tumor cells in regions of tumors that are receiving little oxygen, while sparing those in the more aerobic tumor "rim." The combination of the modified bacteria and Doxil, they found, delivered higher concentrations of the liposome's contents than could be achieved when Doxil was delivered as a single agent.
After seeing the increased efficacy of the combination therapy, the researchers sought to identify how the bacteria helped achieve this effect. They discovered a previously unidentified protein, which they dubbed liposomase, that seemed to be primarily responsible for efficiently disrupting the liposomes' fatty membrane in the tumor and ensuring that a greater amount of drug was delivered to the tumor cells.
"Because virtually any therapeutic agent can be packaged in liposomes and can thereby act as a 'prodrug,'" they wrote, "liposomase offers a number of possibilities for the specific delivery of drugs to tumors."
Brain Scans Show Structural Effects of Chemotherapy
The cognitive impairments demonstrated by breast cancer patients who undergo chemotherapy - symptoms commonly called "chemobrain" - may be related to structural brain changes, according to Japanese researchers in a study published early online November 27 in Cancer.
The researchers used high-resolution brain magnetic resonance imaging to look at the distribution of gray and white brain matter regions in women who received chemotherapy after surgery and women who did not receive chemotherapy, with a set of healthy controls for comparison.
Fifty-one women who received chemotherapy were scanned in the first year after surgery, and 73 women were scanned 3 years after their surgery; 55 women who didn't receive chemotherapy were scanned in the first year after surgery, and 59 were scanned 3 years after surgery. The women received Wechsler Memory Scale-Revised testing for cognitive indices including attention, concentration, and visual memory.
The researchers found that in the first year of chemotherapy treatment, women had smaller right-prefrontal brain regions and smaller parahippocampal gyri - regions that are associated with memory - than women who didn't receive chemotherapy, and these changes correlated with decreased cognitive function. Other areas with similar shrinkage, also associated with memory, included the superior and middle-frontal gyri, the cingulated gyrus, and the precuneus.By contrast, these structural differences were not seen in the group that was analyzed 3 years after surgery and chemotherapy, leading the authors to suggest "that the brain volume change related to adjuvant chemotherapy may well recover over the course of time." They noted that while other studies have shown cognitive effects lasting longer than 3 years, these studies have also demonstrated eventual cognitive recovery.
Smoking Cessation Web Sites' Usage and Quality Studied
The types of smokers who are accessing the Web and the quality of Web-assisted tobacco intervention (WATI) sites were reported in two studies published in the December 1 Nicotine & Tobacco Research. Each study focused on a product developed or study funded by NCI's Tobacco Control Research Branch (TCRB) in DCCPS.
To help developers of smoking cessation programs improve the content and delivery of resources to both groups, the first study compared smokers who use the Internet with those who do not. Using data from the 2003 NCI Health Information National Trends Survey (HINTS), TCRB scientists compared characteristics of 728 Internet-using smokers with 516 non-Internet-using smokers.
"Our results showed that compared with smokers not on the Internet, those on the Internet had higher income and were more likely to be employed, despite having a younger age," noted NCI researchers Drs. Jacqueline L. Stoddard and Erik M. Augustson. "Internet-connected smokers also reported less psychological distress, fewer barriers to health care, and a greater interest in quitting smoking."
For smokers who didn't use the Web, the most common reason cited was a lack of familiarity with the Internet and a concern about the complexity of gaining access. Because this group also reported a high level of trust in information and advice from family and friends, the researchers suggested that campaigns target friends and families of smokers to increase Internet utilization for the purpose of quitting smoking.A second study surveyed current and former smokers who had visited a WATI site to determine which of the Internet smoking cessation sites were most popular and how smokers rated their quality. The 706 U.S. respondents cited 133 different Web sites. "Surprisingly, two of the three most frequently visited Web sites were owned by tobacco companies," noted researcher Dr. Jean-Francois Etter of the University of Geneva, Switzerland. However, these two sites were not perceived as helpful by smokers, the study reported. In contrast, Smokefree.gov, a U.S. Department of Health and Human Services (HHS) Web site, received the highest quality rating of the sites and was the second most frequently recommended site by smokers to their friends.
Following are newly released NCI research funding opportunities:
Limited Competition for Supplements to Clinical and Translational Science Awards to Plan for Pilot Projects to Apply the National Clinical Research Associates Model in Community Engagement Activities (UL1)
This RFA is affiliated with RFA-RM-06-002, which was released on October 12, 2005. This funding opportunity will use the UL1 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3575. Inquiries: Dr. Anthony Hayward - email@example.com
Symptom Clusters in Cancer and Immune Disorders
This is a renewal of PA-05-004. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3567. Inquiries: Dr. Ann O'Mara - firstname.lastname@example.com
Basic and Translational Research in Emotion
This is a renewal of PA-06-380. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3568. Inquiries: Dr. Kevin Quinn - email@example.com
Chronic Illness Self-Management in Children and Adolescents (R01)
This is a renewal of PA-03-159. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3572. Inquiries: Dr. Ann O'Mara - firstname.lastname@example.com
Chronic Illness Self-Management in Children and Adolescents (R03)
This is a renewal of PA-03-159. This funding opportunity will use the R03 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3573. Inquiries: Dr. Ann O'Mara - email@example.com
Chronic Illness Self-Management in Children and Adolescents (R21)
This is a renewal of PA-03-159. This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3574. Inquiries: Dr. Ann O'Mara - firstname.lastname@example.com
Understanding and Promoting Health Literacy
This is a renewal of PAR-04-116. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3569. Inquiries: Dr. Sabra F. Woolley - firstname.lastname@example.com
Dissemination and Implementation Research in Health
This is a renewal of PAR-06-039. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3570. Inquiries: Dr. Jon F. Kerner - firstname.lastname@example.com
Institutional Clinical and Translational Science Award
This is a renewal of RFA-RM-06-002. This funding opportunity will use the U54, K12, and T32 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3571. Inquiries: Dr. Anthony Hayward - firstname.lastname@example.com
Cancer Prevention Stakes Are High for Dietary Intervention Research
The field of prevention is public health's first line of defense against cancer. A key strategy has become short-term clinical nutrition trials linked to rigorous basic nutritional science, says Dr. Peter Greenwald, director of NCI's Division of Cancer Prevention (DCP).
The presence or absence of certain bioactive food components - along with other lifestyle factors such as exercising throughout life - are now thought to significantly affect one's risk for cancer. Identifying these lifestyle factors "has been one of the most important medical contributions for improving the public health in the past half century," says Dr. Greenwald.
In 1981, the idea became concrete after Drs. Richard Doll and Richard Peto from Oxford University used meta-analysis and epidemiologic studies to show that 30 percent of deaths worldwide were attributable to tobacco. Dietary risk factors were roughly estimated to account for even more - as much as 35 percent of cancer deaths. "However," explains Dr. Greenwald, "although obesity is known to increase risk and physical activity to be beneficial, much more basic nutritional research is needed to better understand the role of bioactive food components."
The epidemiologic lens on nutrition confirms the impact of lifestyle. A recent study led by Dr. Eugenia Calle of the American Cancer Society estimated that "the proportion of all deaths from cancer that is attributable to overweight and obesity in U.S. adults 50 years of age or older may be as high as 14 percent in men and 20 percent in women."
The challenge for cancer prevention is to transform the insights from nutritional science and risk numbers from observational epidemiology into cancers averted and lives saved. Producing scientific evidence is only the first step, notes Dr. Greenwald, because cancer prevention requires changing human behavior in a fundamental way. "Working with city planners, school systems, employers, markets, restaurants, and others in our communities would make this much easier for many people," he explains.
A magic molecule in a pill?
Multivitamins and mineral supplements (MVMs) are being used by half of American adults, but may produce different effects than the same ingredients that occur naturally in foods. Adverse effects have been linked to megadoses of these ingredients, although most commonly consumed MVMs don't exceed the U.S. Department of Agriculture's Recommended Dietary Allowance (RDA).
In May, NCI and the NIH Office of Dietary Supplements (ODS) were two of the sponsors of the "NIH State-of-the-Science Conference on Multivitamin/Mineral Supplements and Chronic Disease Prevention," which looked closely at the randomized controlled trials evidence. The expert panel concluded that, although dietary supplements and MVMs "are now used by more than half the population…the present evidence is insufficient to recommend either for or against [their use] by the American public to prevent chronic disease."
"It is also important to remember," points out Dr. Paul M. Coates, director of ODS, "that people who take MVMs tend to be more health conscious than nonusers. For example, they're more likely to eat healthier diets and exercise regularly, which makes it harder to determine if the MVMs themselves are actually responsible for any improvements in health."
Back to the drawing board?
ATBC and CARET were 2 of the 9 large phase III trials that composed the first generation of nutritional interventions in cancer prevention, which together enrolled nearly 150,000 participants.
Lessons learned from these first-generation trials will help to evolve the model, notes Dr. Greenwald, because "there are already more exciting leads of how bioactive food components may reduce cancer risk than there are practical possibilities for phase III trials." Thus, newer trials need to reflect what has been learned so far.
The NCI-sponsored 30,000-participant General Nutrition Trial in China tested a number of different pill formulation and packaging complexities, using a design that allows researchers to look at biological interactions between agents and incorporates multiple primary endpoints, assessing other major conditions such as diabetes and cardiovascular disease. Such multifactorial approaches should become a design of choice, Dr. Greenwald and others believe.
A second promising strategy is the use of biomarkers, which could help to establish eligibility criteria for participants and may be a good way to validate how much of the substances being tested actually arrive in the target tissues.
Other technical issues also are critical for more efficient and productive nutrition trials. Certain interventions take longer to manifest their effects; the duration of the intervention should not be set but instead depend on a number of factors.
"It will be important to carefully consider the doses of each dietary supplement ingredient given to study participants," says Dr. Coates. "Rather than megadoses, they should be in line with RDA levels."
"The beta-carotene/lung cancer link established a new paradigm for how to think about potential side effects," says Dr. Greenwald, which requires careful consideration beyond effects on cancer alone to monitor other major causes of morbidity and mortality.
Careful thinking about how to prepare for and mount such trials was a primary goal of a 2003 workshop at the Fred Hutchison Cancer Center entitled "Research Strategies for the Study of Nutrition, Physical Activity and Chronic Disease."
"We came away with a very cogent, though admittedly ambitious, set of recommendations," says Dr. John Milner, chief of DCP's Nutritional Sciences Research Group. "When an intervention appears biologically plausible and promises substantial potential benefits for the public health, funding should be found to mount a full-scale clinical trial."Dr. Greenwald sees a bright future for nutritional intervention research. He believes short-term phase II trials linked to intensive basic nutrition science studies are a key direction for the future. These will include use of modern research technologies. When enough evidence has been gathered to make the case for a large-scale trial, these generally should have multiple disease endpoints, biorepositories, and long-term follow-up of the participants to document late beneficial or adverse effects.
By Addison Greenwood
Combination Therapy for High-Risk Prostate Cancer
Name of the Trial
Principal Investigators
Why This Trial Is Important
No chemotherapy drug has been approved to treat newly diagnosed high-risk patients, who often get radiation therapy to kill cancer cells in and near the prostate, as well as hormone (antiandrogen) therapy to block the growth and spread of cancer cells that survive radiation.
In this trial, after initial radiation and hormone therapy, men with localized, high-risk, androgen-responsive prostate cancer will be treated with the drugs docetaxel and prednisone. Use of these drugs has improved survival - and was approved by the FDA - for patients with metastatic prostate cancer that is no longer responsive to androgens (androgen-independent disease).
"We hope docetaxel's ability to disrupt microtubule biology will prove effective against micrometastatic prostate disease," said Dr. Sandler. Microtubules are an important part of the machinery cells use to divide and multiply. "The other three major cancers - breast, colon, and lung - all respond to adjuvant chemotherapy, and such a treatment would be widely used by prostate patients."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Drs. Robert Yarchoan and Hiroaki (Mitch) Mitsuya of NCI's HIV and Aids Malignancy Branch in the Center for Cancer Research (CCR) will receive the first NIH World AIDS Day Award in recognition for their outstanding scientific contributions to HIV/AIDS research at NIH.
The announcement was made on December 1 to coincide with World AIDS Day. The award, sponsored by the NIH Office of AIDS Research and the National Institute of Allergy and Infectious Diseases, will be presented at a ceremony on January 11, 2007, at the NIH Institute and Center Directors meeting, where the recipients will also give a brief presentation on their research.
NCI Releases New Tobacco Control Monograph
Intended for health professionals, the monograph explains the conceptual framework and methodological approach used in the evaluation, a paradigm that will be useful in assessing future tobacco-use prevention and control efforts in the United States and around the world.
As one measure of its success, ASSIST interventions were adopted in numerous settings beyond ASSIST states, and tailored to state and local conditions. Aspects of the intervention strategy are now being applied to other public health issues, such as physical inactivity and obesity.
The monograph can be found at http://cancercontrol.cancer.gov/tcrb/monographs/17/. Print copies also are available free of charge.
NCI Introduces New Database
The "NCI-Nature Curated" section of the database currently contains 32 pathways and 1,327 interactions. Each of these pathways is verified by one or more experts in the field. All pathways and interactions are human.
CCR to Sponsor Cancer Prevention Think Tank
The forum aims to identify and prioritize promising opportunities for high-impact cancer prevention research, and to enhance a collaborative response to these opportunities within CCR and with other NCI divisions, including the Division of Cancer Treatment and Diagnosis and DCP.
NCI and non-NCI speakers, plus two panels of experts, will address the following questions during a full-day's agenda: What are the best molecular targets for cancer prevention? Are there biomarkers that reliably predict the likelihood of cancer endpoints? Can molecularly targeted nutritional interventions be designed? What prevention studies should get high priority?
For more information, go to http://web.ncifcrf.gov/events/CancerPreventionThinkTank2006/default.asp.
Geographical Information Systems Inform Cancer Research
NCI can help researchers use GIS by providing tools to analyze spatial patterns and trends, and to evaluate the impact of cancer control interventions, as well as geographic, social, behavioral, genetic, and health care delivery factors on the cancer burden.
For more information on GIS, go to http://gis.cancer.gov. To order a copy of the brochure, go to https://pubs.cancer.gov/ncipl.


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1-3 of 3


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I agree that what we have isn't working. I don't want a placebo, like Kate said, though. I want a real solution and not just the ability to say I tried something.
But like we all agree, there are many different angles and we need to work on all of them to make real change happen.


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NEW YORK (Reuters) - China's largest maker of auto parts won an auction for A123 Systems Inc
Wanxiang Group Corp's bid of $256.6 million topped a joint bid from Johnson Controls Inc
The sale did not include A123's Michigan-based government business that works with the U.S. Defense Department, which was instead sold to Navitas Systems for $2.25 million, A123 said.
Wanxiang's winning bid came only one day after the Canadian government approved a controversial deal allowing China's state-owned oil company CNOOC <0883.HK> to buy energy company Nexen Inc
The sale must be approved by Delaware Bankruptcy Court judge Kevin Carey at a hearing scheduled for Tuesday.
Opposition to the deal will likely focus on the Committee on Foreign Investment in the United States, which would need to approve the sale to Wanxiang.
U.S. politicians and retired military leaders have already pressed the government panel to reject Wanxiang.
(Reporting By Edward McAllister; Editing by Diane Craft)


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$ 150.00
Chic, modern, and elegant, this ring features a sleek spike silhouette. It shines in rose gold PVD metal embellished with sparkling clear crystal pavé. Add matching pieces for extra impact.
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Find an Internship or Volunteer in Acme, Pennsylvania ( PA )
If you're looking for internships or volunteer work in Acme, Pennsylvania or even to get a summer job, you've come to the right place! With over 30,000 around the county, chances are that GrooveJob.com has the right job for you and wants to be your only source for finding internships and volunteer positions in Acme, Pennsylvania.
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|Browse by Employer (Click On Logos)
|Click for Intern or Volunteer at SEAWORLD ADVENTURE PARK
|Click for Intern or Volunteer at INROADS
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Engineering Intern - Summer 2015 (Jeannette, PA)
Elliott offers a variety of paid summer internship opportunities for engineering students to gain hands-on experience in the rotating...
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Pittsburgh, PA
Ticket Sales & Service Internship (Sports Marketing/Sales)
This internship will assist the Ticket Sales Department (Premium, Retention, New Business and Groups) with various season and off-season...
Pittsburgh, PA
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$50 billion: According to EQECAT, a firm that estimates storm damage, that's the total cost of the destruction caused by Hurricane Sandy throughout the country. Originally, they estimated total damage at $30 billion.
620,000: That's the peak amount of power outages in Connecticut. Both United Illuminating and Connecticut Light & Power hope to restore electricity to most by Monday.
738: Connecticut has 738 polling places, and many were left in the dark, prompting concerns about the upcoming Nov. 6 election. Most, if not all, of the polling places are expected to have electricity by the time polls open.
74: Hurricane Sandy was blamed for the death of at least 74 people as of Friday, according to the New York Daily News. Three people were killed in Connecticut.
96 mph: The strongest gust of wind in the northeast was recorded in Eaton's Neck, N.Y. Connecticut saw 85 mph gusts in Madison, according to the National Weather Service. Speeds above 74 mph are considered hurricane strength.
1.1 percent: The Strategic Resource Group, a retail consulting firm, estimates that 1.1 percent of all holiday sales were lost due to the storm.
750: Generators were a valuable commodity this past week. Home Depot stores in the northeast recently received 750 truckloads of generators and other supplies.


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By Kelsea Stahler, Hollywood.com Staff
The Manti Te'o story has many sports journalists feeling the irrevocable sting of not double-checking the details. How could so many professionals, whose jobs are to dig up the dirt and check the facts, miss the detail that Te'o's inspiration for his Heisman Trophy-eligible 2012 season was a woman who didn't exist? In hindsight, it seems inconceivable. But the answer is simple. The story in which Te'o lost his girlfriend right after losing his grandmother and right before playing the best football of his Notre Dame career is prime for a movie a la Rudy or Miracle, or, perhaps, a Manti Te'o reality TV show.
Even before the Te'o story began to mimic MTV's reality hit Catfish: The TV Show, it already seemed prime to spark reality fame for the Notre Dame linebacker. How could anyone resist such an inspirational story? We couldn't. We're not wired that way. Throughout the sports and entertainment worlds, it's evident that we've been trained to crave triumph over trouble in every celeb, hero, and role model. Many of our most beloved sports stars are beloved because they succeed after navigating dire straits. Even our favorite celebrities have to have some back story to get us on board. And of course there's one pop culture behemoth that practically subsists on exploiting stories of adversity: American Idol. The problem is, the more success-after-tragedy tales we witness, the more outrageous these success tales need to be. It's no wonder we accepted a tragedy like Te'o's reported double loss; we could practically see the reality TV sob story background reel playing in our heads and it had us salivating.
It's a factor that explains why Idol made headlines following the Season 12 premiere, when New York contestant Evan Ruggiero told his tale of surviving cancer and having his leg amputated only to be sent home by the judges because he wasn't ready to compete on the singing series. This wasn't what we signed up for. We were duped. Where was that gratification of the good feeling after the sad story? Idol always delivers an overdose of that saccharine-soaked hope, giving us multiple contestants a year who defy the odds and restore the American dream; and in some cases these stories produce winners, like Season 11's Phillip Phillips, who overcame his severe health problems despite wanting to quit multiple times during the show. In past years, contestants with great stories didn't even need to be all that good, like Season 10's Chris Medina, who sneaked by without vocal chops thanks to being selfless enough to play nurse to his brain-damaged fiancée. It's hard to accept now that only some people get a ticket to Hollywood after facing periods of great sadness. We cling to the notion that there is always a way to surpass even the greatest roadblock, and it appears we need it now more than ever.
Our favorite stars are greatly comprised of sobs-to-smiles stories. It's nothing new in the sports world, where Te'o is just the cherry on top of a mountain of trying tales: Jackie Robinson defeating the race barrier to join the Brooklyn Dodgers in 1947, Magic Johnson returning to the Lakers after being diagnosed as HIV positive, Ted Williams being a WWII vet and a 19-time MLB All-star, Josh Hamilton besting his years-long drug addiction to become the American League MVP in 2010, to name a few. Heck, the reason we're so obsessed with Lance Armstrong and his doping scandal is because we heralded him as a miracle athlete after her survived cancer and won multiple Tour de France titles. And it's why we're watching Te'o like a hawk.
These triumphant stories have also become integral to the celeb realm, where putting a 17-year-old from Kentwood, La. in a sports bra in the music video for "(Hit Me) Baby One More Time" was once enough to make a girl a superstar, without digging into her past life. Now, we want it up front. Just look at Justin Bieber, who just surpassed Lady Gaga as the most-followed celebrity on Twitter and who's managed to make headlines every day this week simply for having the ability to use a cell phone camera and post images to Instagram. He comes from humble beginnings' he's the child 17-year-old Patti Mallette refused to abort despite being pressured to do so. Years of living in low-income housing later, the Biebs was discovered via Youtube, saving himself and his young mother from further struggle. Then there's the beloved author J.K. Rowling, who added a famous face to her famous name when we learned she overcame crippling poverty with her Harry Potter series and became a celebrity in her own right (you may know Suzanne Collins' name, but few would see her face and know she wrote The Hunger Games). Demi Lovato went from Disney Channel kid to a household name when her she emerged like a healthy new butterfly on the other side of a stint in rehab for drugs and alcohol abuse, self-mutilation, and a subsequent diagnosis of bipolar disorder.
Even Jennifer Lawrence, who's award worthy on her own, has gained momentum in the Best Actress race heading into the Oscar season at least partially due to her "inability" (or refusal, depending on how you look at it) to fit into Hollywood culture as-is. In consistently shirking the prescribed Hollywood ways, like accepting her body even if she's considered "fat" in Tinseltown and refusing to elevate the acting profession above less glamorous ones, she's actually given herself the highest form of Hollywood currency: a little bit of adversity. If she's atypical, she's fighting the odds. And if you've been paying attention, we've learned to love that.
But do we really need these stories right now? Why are they so prevalent? The aforementioned celebs certainly aren't the first ones to overcome something and thus earn a place in our hearts (just ask Oprah Winfrey, who came into our lives in the late '80s after conquering a horrible childhood that included allegations of rape and, later, a miscarriage in her early teens).
Still, it's impossible to deny the relevance of the underdog story right now, especially in the face of the Te'o story. We want it so bad, we were willing to believe it blindly. We shouldn't beat ourselves up too greatly: it makes sense in America right now. The economic climate has been bleak since the housing crisis, unemployment rates have steadily risen for the past 10 years, and the future is more precarious than ever. It's in times like these that entertainment begins to reflect our fears. Looking back at the 1930s, during and after the Great Depression, we saw the emergence of superheroes like Captain America, who overcame his cripplingly tiny stature to become a freedom fighter with a dose of Super Serum, and Batman, an orphan who grew up to own a multi-national corporation and a secret cave of tools for fighting crime. When times are tough, we seek triumph over hardship in entertainment, and that pattern is clearly in effect today. Add to that pattern a hopeless addiction to reality TV and celebs like Kim Kardashian (who lacks any discernible talent, but packs a tawdry back story), and it's not hard to see how we've landed here with a pile of overcomers on a pedestal.
The question that remains is, what will happen next? Now that stories like Te'o's and Armstrong's have shattered the shiny surface of the classic underdog tale, are we growing weary of it? Is that why watching American Idol judges crush a cancer survivor's dreams is a possibility now? Now that the underdog is everywhere, are we moments away from being bored with him?
Follow Kelsea on Twitter @KelseaStahler
[Photo Credit: Getty; WENN]
Why Catfish is the New Jersey Shore (Thanks to Manti Te'o)
'American Idol' Recap: What Made Nicki Minaj Walk Out in Charlotte?
'Argo' Nabs Best Picture Globe, Could Oscar Be Next?
From Our Partners:
Celebs as Kids: Guess Who? (Celebuzz)
Craziest Celebrity Swimsuits Ever (Celebuzz)


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Software Map
Tag cloud | Project Tree | Project List
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Now limiting view to projects in the following categories:
Environment :: No Input/Output (Daemon) [Remove This Filter]
Programming Language :: SQL [Remove This Filter]
Operating System > POSIX > Linux
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3 projects in result set.
|0. Table Audit - PostgreSQL Table Log uses a trigger to log any INSERTs, UPDATEs
and DELETEs on a specific table into another table.
The second part of tablelog is able to restore the state of the
original table or of a specific row for any time in the past.
|Activity Percentile: 81.60
Activity Ranking: 24.00
Registered: 2005-02-20 11:52
|1. PostgreStats - PostgreStats enables DBAs to extract, store, monitor and display online statistics from PostgreSQL's Statistic Collector in timed-cycles in views such as Monthly Snapshot, Daily Individual, Month VS Month comparison, Weekly Trending and Yearly Snapshot.
|Activity Percentile: 42.40
Activity Ranking: 73.00
Registered: 2013-02-08 20:38
|2. Audit Trail II - PostgreSQL Table Auditing module: This loadable module defines a single public function which tracks changes (insert, update, delete) to a table in an audit trail. Tracks column level changes instead of rows to optimize storage.
|Activity Percentile: 39.20
Activity Ranking: 77.00
Registered: 2006-12-13 15:25


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Carpet Cleaning for Up to Three Rooms or an Entire Home from Saddleback Valley Chemdry (Up to 74% Off) $49 at Groupon


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Shock Doctor Ultra Boxer Brief with Ultra Carbon Flex Cup
The Shock Doctor Ultra Boxer Brief is packed with the comfort and protection you need to stay focused on training and competing! Constructed of four-way stretch material with a slip-resistant comfort waistband and the Shock Doctor X-STATIC® anti-microbial lining to fight against bacteria growth and odor, this boxer and cup set has every angle of your protection covered! The included Ultra Carbon Flex Cup is the most advanced multi-stage impact protection that transfers shock away from vital areas while the flex-curve and gel pad maximize comfort and fit!
(based on 4 reviews)
Ratings Distribution
5 Stars
4 Stars
3 Stars
2 Stars
1 Stars
of respondents would recommend this to a friend.
Best Uses
Feels too small
Feels true to size
75% (3 reviews)
(3 reviews)
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Reviewed by 4 customers
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Good protection, weird fitting
By Falck
from Norway
About Me Gym Rat
Comments about Shock Doctor Ultra Compression Short with Ultra Carbon Flex Cup:
The cup itself seems to be top notch, but the fitting is too loose for me (and others as I've seen lately on forums).
Bottom Line No, I would not recommend this to a friend
Was this review helpful? Yes / No
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Comment on this review
Great Shorts
By DM
from Vancouver
About Me Casual/ Recreational
Great shorts.. really comfortable, better than the older Shock Doctor shorts.
Bottom Line Yes, I would recommend this to a friend
Comfort and protection at a low price
By Linda
from melbourne
Use this for martial arts and it feels great and comfortable, it sits well and does not move around.
(0 of 1 customers found this review helpful)
great shorts!
By just plain jerry
from Ohio
About Me Competitive Athlete
great all around fit, comfortable, I really like these shorts I'm writing review as I'm ordering another pair. very strongly recommend! The cup is excellent as well. I will say the cup sleeve isnt as tight as I'd like it to be. But if your looking for good shorts..buy these!
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We offer a huge variety of bags from diaper bags for parents to backpacks for children. All Lässig styles are designed to be both functional and stylish. When creating our products we incorporate the needs of our customers, fashion and our own innovation.
Our Philosophy from our employees to our products is that of living with spirit and style. We offer a diverse line of bags which are an ideal blend of versatility and fashion, with convenient features and stylish designs. They are easy to care for, durable and comfortable regardless of which style you are going for.
You do not have to give up your own style to be a Mum.
Find us on Facebook: Lassig Nappy Bags Australia. Be the first to knowabout new ranges, hot promotion and discounts offered on our website.
Each Nappy Bag comes with a matching change mat, bottle bag, utilities pouch, hooks to hang from strollers, wet pocket for dirty clothes and lots more.
By popular demand we have added a backpack to our range!
The Lassig Casual Backpack is perfect for any outing with bub and best of all allows you to have your hands free for shopping, pushing a stroller or chasing your little one.
Available in Multimix Black.
This amazing backpack has just been added to the Lassig website and can be order NOW.
Measurements – 12.6 x 6.3 x 15.8
Material - 100% polyester (sustainable materials)
Weight - 940g
- Well-organised compartments
- Water-repellent change mat
- Insulated, removable bottle holder
- Zip pouch
- Microbial wet-pocket
- Removable compartment for jars
- Stroller hooks
Parents and kids will love the 4Kids Wildlife Range, with their bright and colourful animals designs. Kids are going to go WILD for them.
The Mini Backpack is perfect for childcare, school or a family outing offering chest straps, pocket, name badge and adjustable straps. RRP $39.95
Travelling with kids can sometimes be difficult and stressful, not with Lassig, they can now travel in style bringing along their favourite toys and books to keep them entertained on that long flight. The Lassig Trolley offers a large main compartment, lashing strap, zip pockets in the front, net pockets and name badge. RRP $69.95
The Mini Washbag matches their trolley and has plenty of space for all their toiletry needs. Offering main compartment and net pockets. RRP $24.95
The only difficult part for kids now is too choose their favourite animal design, Elephant, Tiger, Turtle, Giraffe, Rhino and Bird.
To find out your local stockist or more information please email us email@example.com or visit the website www.lassig.com.au
END OF MONTH SALE: Our next end of month sale will be on Friday 25th July 2014 at our Melbourne Head Office 11 Maurice Court, Nunawading VIC.
The last Friday of every month The Amazing Baby Company Head office located in Nunawading, Melbourne runs an end of month sale. The sale is held to clear out our ex-demo, ex-sample and discontinued stock. Everything is in great working order and all purchases come with a warranty. Some things are new and have never been used. There will be lots of great products which can be used for birthdays, baby showers or gifts. Where: The Amazing Baby Company (Formerly Baby Jogger) Address: 11 Maurice Court, Nunawading Vic 3131 (Off Rooks Road) Time: 9.30am-2.30pm. We accept cash, Eftpos and most credit cards (no AMEX). We also now except interstate customers, freight costs will vary depending on items.
Please note that we will not discuss stock or prices over the phone.
Contact: 03 8872 6772
User reviewsAdd a Business Listing FREE
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Baby jogger city elite and mini doubleBy corinne.devidas on 2/12/2011 6:15:32 AM
I've had this pram for two years and it has been fantastic! I particularly love the big canopy and the ease to fold. I have done a lot of km's and it has lasted well - still looks brand new. I've also just upgraded (expanded) to the city mini double now that number 2 child has arrived - for a double it's still very light and so far I have fitted through every door way. My (...) Read more
baby jogger city miniBy becj2 on 1/12/2011 4:12:29 PM
I have had 5 prams before i purchased the city mini. wish that i had bought it at the start. love how light and compact it is. My son looks so comfy in it and has no trouble falling asleep while we are out shopping.. I Iove the large canopy it provides so much protection from the sun and not to mention when you get caught in the rain it keeps bubs nice and dry. Would be lo (...) Read more
baby jogger city eliteBy fluff1 on 1/12/2011 11:57:27 AM
I'm an active person and went looking for a pram that suited my needs- something that was comfortable for my baby, suitable for walking and could "4 wheel drive". I have horses and needed a pram that could cover boggy sand, rough ground and smooth footpaths. My BJCE does this easily and has great suspension and pneumatic (no punctures) tyres to give my baby a smooth ride. (...) Read more
Baby Jogger City SelectBy Sarah on 29/11/2011 1:44:54 PM
We did a lot of research before buying this pram and it seemed to be the most versatile on the market for transporting baby and toddler together. So far it has lived up to our expectations. It has so many options, like bassinet and toddler seat, or capsule and toddler seat and we love that you can have any of the seats in any position, facing either way. It is also very st (...) Read more
Baby Jogger City Mini & Glider BoardBy plbartlett on 29/11/2011 1:19:26 AM
I bought this pram when my youngest was 17months old and my eldest 3 1/2 yrs old. I love how light weight the City Mini is, great for your back getting it in and out of the car. It is also so compact when folded, lots more room in my car boot than with my old pram. It is really easy to push and manouvre. I don't mind that it didn't come with other accessories, I didn't nee (...) Read more
Baby Jogger City SelectBy Eboni on 28/11/2011 5:33:11 PM
This is by far the best purchase we made for bubs. And with a second coming up it's so. Easy only having to buy an extra seat and not a whole new pram. Love it! I get soo many comments and enquiries on it while I'm out.
Baby Jogger City SelectBy Kathryn on 28/11/2011 1:27:36 PM
I currently have 2 children (aged 2 and 1) and have been using the city select for around 12 months now. We upgraded from our city elite as I had trouble with the toddler seat stability (previous Maclaren owner too). This pram is a dream to fold, is light enough for me to move around at the shops with one hand and comfortably takes the 2 kids with lots of different configu (...) Read more
Baby Jogger City Mini doubleBy SarahKimbo on 28/11/2011 1:11:29 PM
Hi there mums and dads. I have the BJ City Mini Double. The first thing that caught my eye with this pram was the great hood coverage. It fits through standard doorways, is easy to manoeuvre and my twins only complain when they are hungry! LOL! I have the rain cover for it too, which is easy to attach. My four year old loves the glider( which is also quick to attach) to st (...) Read more
Baby jogger city eliteBy Natalie on 28/11/2011 12:18:23 PM
Love this pram! My partner and I fight over who will push it. Great quality components and love how easy it is to fold up. Our only issue is that we now have to upgrade to a city select as bubs number 2 is on the way. Have looked at all the other brands but we can't go past the components that make the baby jogger prams so great so it will be a worthwhile investment
city mini singleBy champerelli on 28/11/2011 12:06:22 PM
i have a city mini single and it is so good 2 use plus it folds up so tiny and flat i love it


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Find out about The Winesleuth
Who is The Winesleuth?I'm an American ex-pat who is fascinated by wine. Previous to my arrival in London, I had done a sommelier course in Buenos Aires, Argentina so I knew I wanted to be in the wine trade but where to start? I started where so many people in the UK wine trade start, Oddbins. I was fortunate in that Oddbins back then had a great wine education partnership with the Wine and Spirit Educational Trust and I was able take the WSET courses. I currently have the WSET Advanced Certificate as well as holding a UK personal alcohol license.
Another advantage to working at Oddbins was that I had access to all the wine trade shows. Imagine, being able to go and try as many wines as you could in one day! Whew! I have to admit, I didn't do much spitting back then and the next day, I was wishing I had at least taken better notes. I started looking around on the web for blogs that covered the London wine scene and found there were none. Well, none that appealed to me. None that were a mix of trade and consumer views and opinions. And none that really talked about what a great centre of wine this fabulous city of London is. So I rolled up my sleeves, bought a domain name and the rest, as they say, is The Winesleuth history…
9 Comments
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Preston recently posted…Preston
Hi Denise, I work for Hallgarten Druitt as well as running my own website http://www.wineman.co.uk if you would like any samples of our wines please let me know
You have a great blog here. I'd really like to request a wine review on behalf of a wine client of mine. I've emailed you with the details. Keep the great posts coming.
Hi there!
Do you feature South African Wines? We have some really stunning International Award Winning wines but somehow these do not get the attention they deserve. Some of our lesser know boutique Wineries are also producing some really stunning wines.
Hi, please drop me an email with more details and I will get back to you. thanks!
Great to meet you today, looks a great blog as well
Dear Denise,
I'd like to exchange links on our blogs. I feel that many of your readers would appreciate what my blog has to offer. Readers can use my site to find Wineries, wine bars etc. throughout North America. They can also follow my daily Video Vocabulary of Wine where we interview a winemaker or winery owner about a specific term used in the world of wine. The videos are being compiled to create the first ever video wine dictionary! Just for fun I'm also producing a new web series called "Just A Taste." Each week we review one wine and give updates from the world of wine in a humorous format. You can watch a webisode here: http://www.winetrippingtv.com/index.php?option=com_content&view=category&layout=blog&id=36&Itemid=50
I sincerely believe that my blog is offering something new and unique in the world of wine!
If you would like to exchange links, please send me an email and I'll get yours up on my blog roll right away.
Thank you,
Dan Ganshirt
Hi Denise,
We met briefly at the Wine Bloggers Conference. I've just bee checking out your site. May I suggest that you enable an RSS feed on the blog, so that people may subscribe? I think you will find that you get more readers that way.
Dear Denise,
Greetings from Mutineer Magazine. I see you will be attending the Wine Bloggers Conference in Sonoma, and I wanted to touch base with you as I'll be attending and covering the event for a feature story in an upcoming issue of Mutineer Magazine. We are doing a feature story on wine blogs, and will be doing interviews at the Conference to try and put faces and stories to burgeoning wine blogosphere. Here is a link to a PDF of the recently released second issue:
If you are into the magazine, please share our efforts with your blog readers. Feel free to share the PDF link with anyone or even post it on your site.
We are fully committed to being a resource to the blogosphere and doing our part to help develop it into the most relevant format it can be, and I am excited to meet you in person at the conference.
Alan Kropf
Mutineer Magazine
7510 Sunset Blvd.
Los Angeles, CA 90046
"Most promising up and comer" -1winedude
"It is time to embrace the revolution that is Mutineer Magazine" – Arete Wines
"…Mutineer Magazine is 'aimed at a younger generation of wine drinker', and based on the first issue, he is spot on." – Corked
"Take a bit of Maxim, add some A.D.D., throw in some comic book stylings, then get drunk. Now you know how they came up with Mutineer Magazine" – Martini Groove


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Once during your turn (before your attack), you may put Marill from your hand onto Azurill (this counts as evolving Azurill) and remove all damage counters from Azurill.
The Pokémon Company International is not responsible for the content of any linked website that is not operated by The Pokémon Company International. Please note that these websites' privacy policies and security practices may differ from the Pokémon Company International's standards.


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Welcome to Miles Jesu
Miles Jesu participates in the Church's mission principally through the new evangelization: led by the spirit of the Gospel for the sanctification of the world from within as leaven. Our goal is to provide a specific means for the laity to recognize and live out the call to become saints, not only by work but by family and social commitment, and to help others become saints. This calls for leaders in seeking the Kingdom of God by engaging in temporal affairs and by ordering them according to the plan of God.
|Copyright 2013 Miles Jesu. All rights reserved. Sitemap.


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Continuing Education
Prospective Students
Central Penn College prepares graduates for career success by providing an affordable, hands-on education, in three convenient locations and online. We offer associate, bachelor's and master's degrees in fields hiring today, and growing tomorrow.
Central Penn offers hands-on education from real-world experts at three convenient locations to help you finish your degree sooner. With our campus in Summerdale and centers in Lancaster and the Lehigh Valley, you can find a classroom near your home or work. We also offer online courses to fit your studies into your busy life.
Want to learn more about earning your degree at Central Penn? Use our 'Request Information' box to the right — you'll hear from us soon! To hear what others have to say, we encourage you to like us on Facebook, or connect with us on Twitter. We love to answer questions and provide additional information in a format that works for you.
To learn more about our continuing education locations, explore the tabs below.


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A pair of Mariners made a meaningful stop in Spokane Wednesday, visiting sick kids at Sacred Heart Children's Hospital.
Pitcher Charlie Furbush and outfielder Casper Wells were on hand, as were the Mariner Moose and Mike Blowers, for the get well tour. The players spend the afternoon meeting and talking with kids, taking pictures and signing autographs.
The players had an obvious impact on the children, but the Mariners see it the other way around.
"Just a part of making these kids smile and laugh a little bit, it's so important and they really need that," said Wells.
"Just to take their mind off some of the troubles they're going through, just for a few minutes, it makes it worth it," added now-broadcaster Mike Blowers. "It was a lot of fun to come visit the hospital."
Perhaps nothing, though, was better than watching Mariner Moos light up the children's faces.
"When the Moose came and busted through the door they seemed to just glow, and it's really something special to see how excited those kids are, how much excitement you can bring to them."
The Mariners Caravan continues its tour through Washington through the month of January. They are in Walla Walla on Thursday and in Tri-Cities on Friday. They wrap up the tour in Tukwila on January 25.
*Mobile users can see video of the Mariners' visit here: http://bit.ly/UTdrwV


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- Beacon Hill
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We ask that the product be unused, in original boxes (whenever possible), and with all paperwork, parts and accessories in order to ensure credit. Sale merchandise will be issued a credit at the current selling price. Unused items purchased on www.tumi.com can also be returned to a US Tumi full price location. Please make sure to have all paperwork, parts and accessories to ensure credit. Store credit will be issued for items without documentation.
Welcome to the world of Tumi – the finest international brand of travel, business and lifestyle accessories. Since our founding in 1975, Tumi has been dedicated to providing our customers with an outstanding ownership experience.
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Please click here to learn more about the Tumi Warranty.


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Lottery fever is sweeping across Long Island, with Wednesday's Powerball jackpot now above $500 million.
But while locals are rushing to get their tickets before the 10:59 p.m. drawing, we're wondering what any of you would do will all that money.
Share your ideas in the comment stream below.
And for a little extra perspective, check out this Associated Press report published Wednesday about past winners and what cautions they have for the next crop of lotto millionaires.


text: My body is so frustrating. I'm spotting at 6-7 dpo. Our timing this month sucked but I've never had spotting this early. The earliest I've had is 11 dpo. It's a weird pinkish tint which is all new to me too. Not sure what to think and figured I would vent here. Any thoughts why I'm spotting so early?


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Shop for Coffee Makers, French Press and Pour Overs
Coffee makers magically mix hot water and fresh coffee grounds, but many variables effect how your cup of coffee ultimately turns out. We post real reviews and information to help you select the right preparation to satisfy your coffee cravings.
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Bluetooth Engine API for 3rd Edition Feature Pack 2
From Nokia Developer Wiki
Article Metadata
Created: kiran.mudiyam (06 Jun 2008)
Last edited: hamishwillee (19 Jul 2012)
Describe what is the purpose of this SDK, what can and cannot be achieved using it.
Use cases
|Describe here the main use cases for which this API would be useful.
This API can be used to asynchronously ...
Example code
|Use this section to exemplify with small pieces of relevant source code how the API is to be used for implementing API's main use cases.
The following sample code shows how to ...
Example project
|The following project demonstrates the use of the API. It has been tested successfully on ...
Known issues
|Use this section to specify if the API has any known limitations, device specific behavior or if the API is known to be broken on a given device/firmware.


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Apar-T-otel Porta Westfalica Asuncion
Asuncion, Paraguay Hotels & Resorts
Welcome to Asuncion Paraguay. Your comfortable TOP Apartment is waiting for you in the heart of south america to feel just like home....
$3,000 - 90,00
Bristol Hotel
Asuncion, Paraguay Hotels & Resorts
Este Hotel, Con Un Total De 19 Habitaciones, También Ofrece Un Excelente Servicio 24 Horas. ...
$74 Per Night
Hotel Las Margaritas
Asuncion, Paraguay Hotels & Resorts
The Air-Conditioned Hotel Offers 60 Comfortable and Spacious Rooms and Welcomes Guests in a Lobby With 24-Hour Reception and Check-Out Services, a Hotel ...
$360,000 Per Night
Presidente Hotel
Asuncion, Paraguay Hotels & Resorts
With 57 Rooms This Hotel is Designed and Intended For All Those Away from Home Want To Feel At Home. It Has a Constant Monitoring and Control To Improve ...
$102 Per Night
San Diego Hotel
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This Establishment Was Built in 2010. This 40-Room City Hotel'S Work Focuses On Providing a Well Deserved Break and Wide Selection of Entertainment Options. ...
$74 Per Night
Terrazas Del Sol Apart Hotel
Asuncion, Paraguay Hotels & Resorts
The Hotel is located in a quiet, secure and exclusive neighbourhood. We have only 19 rooms, full equipped, that ensure a personal service to our guests. ...
$62 Per Night
Guarani Esplendor
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Meet exclusive luxury and divine comfort at the Guarani Esplendor.. and take pleasure in unparalleled.. attentive service blended with sophisticated interiors ...
$154 Per Night
Internacional Asuncion Hotel
Asuncion, Paraguay Hotels & Resorts
The International Asuncion Hotel and Suites is nine miles from the Asuncion Silvio Pettirossi International airport (ASU) and is less than a mile from ...
$80 Per Night
La Mision Hotel Boutique
Asuncion, Paraguay Hotels & Resorts
The La Mision Hotel Boutique is located 15 minutes away from the airport and close to new downtown city. ...
$180 Per Night
Granados Park Hotel
Asuncion, Paraguay Hotels & Resorts
Granados Park Hotel is a unique 5-star hotel located in downtown Asuncion, Paraguay. The hotel is ideally located in the city center of Asuncion, Paraguay...
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Romantic Weekend Getaways At Hotel San Rafael
Ciudad del Este, Paraguay Hotels & Resorts
It is Hotel with friendly people.Has parking area and patio with some plants.The reception is quite confortable. with a flat-tv screen and some pictures on the wall made by original and traditional woods.The restaurant has woods and glass by the wall...
$35 Per Night/Room
Black Cat Hostel
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Near to the hostel you can find the most important touristic places like the Government Palace, the Congress Building, the Cabildo, the South America's first train station...
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In the heart of downtown Asuncion rises one of the most traditional hotels and best service in the Republic of Paraguay...
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Located in the historic center of the city of Asunción, with easy access to major points, public service...
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Asuncion Hostel
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Asuncion Hostel, a new option to stay at the capital of Paraguay. rnWe are located at 988 Mcal. Estigarr...
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Hotel Maison Suisse
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Hotel Maison is a Suisse-style chalet in Asuncion, in the centre of scenic Villa Morra town....
El Jardin Hostal
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Very well located in the perfect spot to enjoy your holidays....
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Arandu Hostal
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Arandu Hostel is situated in a beautiful house remodeled in the 60's and refurbished...
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Circo Hostel
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Circo Hostel is waiting for you with a warm welcome!...
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El Nomada
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We have rooms with a/c and ensuite bathroom. Hot water 24 hours.Our facilities include free breakfast....
$11 Per Night
|Link Code


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Car flooding with Water
"The best thing about dreams is that fleeting moment, when you are between asleep and awake, when you don't know the difference between reality and fantasy, when for just that one moment you feel with your entire soul that the dream is reality, and it really happened." - Oprah
Dear Lauri,
I had a dream my fiancé was taking me to the ocean and on the way we went over a bridge and our boys flew out of the car and so did my fiancé I was stuck while the car filled up and the next thing I knew I was right there flying next to them. – Sheri 28, Marshall, MI
Lauri: Is there anything going on that you fear is going to pull you away from your fiancé and children? Like a new job or some new responsibility? The bridge is your ability to get through some sort of transition in your life. The rising water suggests you are becoming increasingly overwhelmed and perhaps fearful you're not going to make it through this transition. However, your dream seems to be encouraging you at the end by showing you flying next to your family, as if to say, "Just stick this through and then you'll see that things will really start looking up for you."
Lorie replies: Actually yes. My stress level is through the roof and my boyfriend has been looking for a job or possibly going back to school. But if he went back to school he would have to live in a dorm and not be with us. We are also about to lose our apartment actually and we are trying to find a place to move. With him considering school, I guess I am feeling like I would be left behind in a sense.
Go to www.thedreamzone.com
Join Me on Facebook
Follow Me on Twitter
Read My Blog


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All Beds, All Baths, All Prices, Apartment Apartments Near Harborview in San Diego, CA
More Info
The Harborview neighborhood is a part of San Diego, CA. ForRent.com, an apartment finder service, makes your Harborview rental search easy. Let us guide your search for rentals from the apartments for rent listings provided. To narrow down your All Beds, All Baths, All Prices, Apartment search, select from the Harborview's beds, baths, price, type and amenity links below.
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Broadstone Little Italy
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- Work 1-866-696-0906
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Broadstone Little Italy features Studio, 1 bedroom, 1 bedroom plus den, 2 bedroom, 2 bedroom plus den, & Loft apartments. Perched above San Diego Bay with spectacular seaside views, this styled new residence is at the center of a truly beautiful life. A coastal resort feel influenced by the Amalfi coast. Sparkling bay views from the sun-drenched pool. Outdoor family-style dining with Pacific Breezes. Designer amenities and open-air gathering space.
Other Apartment Search Options
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(888) 999-9999
Thank You! Your email has been sent. We appreciate your interest.


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One day after announcing Sparks Police would not release a name, the City of Sparks has now decided to identify the Sparks Middle School shooter.
It has released this statement:
Earlier today, during an interview covering the legality of withholding the name of the Sparks Middle School shooter, the Sparks City Attorney acknowledged the existence of an online news story by Univision.
The City Attorney's acknowledgement of the Univision news story was misinterpreted as an acknowledgment that the name of the Sparks Middle School shooter mentioned in Univision's report was correct.
Due to the widespread release of the Univision news story, and in order to be fair to the families involved and all news media, the City of Sparks confirms that the name of the Sparks Middle School shooter is: Jose Reyes.
Police say Reyes shot 45-year-old math teacher Michael Landsberry in the chest as he tried to intervene. Two other students were also shot and are both recovering from their wounds.
One of those victims, 12-year-old Mason, spoke to CNN Thursday about his experience.
To help the community heal, several vigils, community prayers and fundraisers are being held in the coming week.
The Sparks Nazarene Church will hold a community prayer Thursday night at 6:30 pm at 2200 El Rancho Drive.
The City of Sparks along with the Washoe County School District will hold a public candlelight vigil at 6pm at the Sparks Marina at the peninsula on the west side. The lighting of floating and handheld candles will begin around sunset. There is a limited supply of candles. Participants are encouraged to bring their own. Parking is also limited around the Marina. As an alternative, parking is available at the Legends at Sparks Marina.
Sparks Christian Fellowship is holding a service called 'Dealing with Tragedy and Where God Is In the Midst of it' at its 510 Greenbrae Drive location Sunday at 9am and 11am. The church will also accept donations for the victims' families.
Landsberry was a member of the Nevada Air National Guard and a Marine. McQueen High School and some military members will salute Landsberry Thursday at the 7pm McQueen home football game. The tribute and salute will happen at halftime.
An all-ages Hip Hop Halloween fundraiser party will be held Friday at Candela Nightclub at 1126 E. 4th Street in Reno. Proceeds benefit the victims of the shooting. Tickets are $10 without a costume and $5 with a costume. It's all-ages until 11pm, then 18+ after 11pm.
A fundraiser for Landsberry will be at Dad's Quick Mart at 5212 Sparks Blvd. Saturday at 10am. There will be a bake sale, car wash and a $5 raffle for $100 worth of gas. Proceeds will benefit the Compassion Fund.
The Heroes Memorial Foundation has created a Facebook Memorial Page for Michael Landsberry at https://www.facebook.com/pages/Remembering-Mr-Michael-Landsberry/767495089932653
They also have a webpage set up at http://heroesmemorial.org/content/master-sergeant-michael-landsberry
The Community Foundation of Western Nevada is hosting a fund to provide financial support to the victims, students, staff, families, and Sparks Middle School in the wake of yesterday's shooting. This fund, The SMS Compassion Fund, is accepting tax-deductible monetary donations. Disbursements will be advised by representatives of the Washoe County School District and the City of Sparks under the oversight of the Community Foundation of Western Nevada, to assure the funds are distributed to meet the needs of the school community as they are identified.
For more information, call the Community Foundation of Western Nevada at 775-333-5499. Thefoundation's website is located at www.nevadafund.org. Donations may be mailed to:Community Foundation of Western Nevada1885 South Arlington AvenueSuite 103Reno, NV 89509Please reference "SMS Compassion Fund"
KTVN-TVPhone: (775) 858-2222Fax: (775) 861-4298
Mailing Address:4925 Energy WayReno, NV 89502


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Nightline anchor and Colby College Alumni Dan Harris opens up about his on-air panic attack on Good Morning American and reveals what he did to help
reduce the stress in his life in
10% Happier: How I Tamed the Voice in My Head, Reduced Stress Without Losing My Edge, and Found Self-Help That Actually Works--A True Story.
National Bestselling author Jennifer Boylan chronicles her journey of changing genders and her experience raising her children in
She's Not There and
Stuck in the Middle with You: A Memoir of Parenting in Three Genders. In
I'm Looking Through You: Growing Up Haunted: A Memoir, Boylan explores what it means to be haunted.
New York Times Best Selling Author and Colby College Clara C. Piper Associate Professor of English Tilar Mazzeo explores the history of
Hotel Ritz on the Place Vendome. Set against the backdrop of 1940s Nazi occupied Paris,
The Hotel on Place Vendome: Life, Death, and Betrayal at the Hotel Ritz in Paris
reveals forbidden affairs and acts of defiance and treachery at one of the most luxurious hotels in the world.
Assistant Professor of History Daniel J. Tortora explores the rich history of a local military outpost in
Fort Halifax: Winslow's Historic Outpost. Learn about the Fort's evolution from a war garrison to a local community gathering spot in this
engaging narrative.
Step back into a rich American history. Acclaimed author and Colby College Alumni Doris Kearns Goodwin, Class of '64, explores America's exciting power dynamics and searches for the true American dream in her books
Lyndon Johnson and the American Dream,
Team of Rivals, and
Wait Till Next Year
By exploring the NYPD's role post 9/11, Colby alumni and Pulitzer Prize-winning journalists Matt Apuzzo and Adam Goldman seek to understand the the measures that Americans take to protect
themselves from real and perceived threats in
Enemies Within: Inside the NYPD's Secret Spying Unit and bin Laden's Final Plot Against America.
Explore the story of the last great march of the King era and the first great showdown of the turbulent years that followed in Colby College Class of '94 alumni
Aram Goudsouzian's Down to the Crossroads: Civil Rights, Black Power, and the Meredith March Against Fear.
Get your groove on with music from the Colby Eight. From old time classics Lullaby of Broadway: A Cappella from The Colby Eight of 1963
and Try to Remember: A Cappella from The Colby Eight, 1955-1963 to modern hits Seven What?: A Cappella from The Colby Eight.
Get lost in the drama of New York City's Upper East Side with Blair, Serena, Nate, and Dan in an autographed copy of your favorite Gossip Girl novel.
Colby College Class of '92 alumni Cecily Von Ziegesar signed several copies of her
Gossip Girl novels at reunion weekend!