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Debra Giller bought a 2003 Dodge caravan, only to learn a few days later she had been sold a stolen vehicle.
And now this mother is left without a car to take her three grandchildren to and from school, but also without a car to take herself to and from medical appointments. She is battling stage 4 bone cancer.
She spotted the van on Craigslist. It was listed for $2,500 with 103,000 miles on it. She went with her son to meet the seller, who said her name was Madison, at a gas station to check out the van.
Her son, Adam, took it for a test spin. He was impressed, and thought it was a perfect vehicle for her. He even got the seller to drop the price to $2,400, and the sale was complete.
Madison even wrote a receipt giving a 30-day money back guarantee if anything goes wrong.
But Giller was not expecting this to go wrong. When she went to put insurance on the van, she made the unfortunate discovery.
"It's horrible. It's totally horrible. To take your money, I mean, I'm sick. My money goes for doctors," she told Fox 2's Ron Savage.
The insurance company confirmed with police that the van was stolen. The Livonia Police took her title and towed the van.
Now, she's out $2,400 and has nothing to drive.
UPDATE: On Friday D & D All American Auto saw the story on Fox 2 News. They have decided to give her a van similar to the one she was trying to buy in the first place. They're giving it to to her at no charge.
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


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Welcome to Hodge Hill District
The district is made up of four Wards: Hodge Hill, Shard End, Washwood Heath and Bordesley Green. The district office is Ward End Park House, situated in Ward End Park, on the Washwood Heath Road. See Ward End Park House for a fascinating insight into the history of this well-known district building.
Hodge Hill District Savings Proposals 2014/15 and 2015/16
As part of the savings that Birmingham City council is making, each District Committee has reviewed their service provision to identify future service savings for 2014/15 and 2015/16. The following attachment gives an outline of the District proposals.
Please send any comments to us via e-mail to firstname.lastname@example.com. Alternatively, you can write to us at Hodge Hill District Office, Ward End Park House, Washwood Heath Road, Ward End, Birmingham, B8 2HB.
Neighbourhood Advice and Information
- Saltley Customer Service Centre (formerly known as the Neighbourhood Office).
The following Neighbourhood Offices offer an appointment only system:
Visit our new events website to find out
what's on in Hodge Hill and across the city
- The Shard (Shard End Neighbourhood Office is situated on the first floor)
- Ward End Library
Leisure Centres
Birmingham City Council, in partnership with the NHS, is now offering all Birmingham residents free swimming, group exercise classes and gym sessions during off-peak periods. For full details go to Be Active.
Community Facilities
The Hodge Hill Constituency Office Meeting Room is available for hire. It can hold up to twelve people, has a large free car park and lovely views over the park. However, it is on the 1st floor and there is no lift access. The charge is £15 per hour, and it's available 09:00-16:30 Monday to Friday. Call 0121 303 9282 to book.
Contact Us
Hodge Hill District Team
Ward End Park House
Ward End Park
Washwood Heath Road
Tel: 0121 303 9282
How to get involved and have your say
If you live or work in Hodge Hill, we want you to be involved in running local services, raise issues which concern you and contribute to decision making in a number of ways.
- District Committee
- Ward Committees - meetings are held regularly and provide a mechanism for members of the public to become involved in the decisions that affect their neighbourhood
- Contact or meet your councillors for Bordesley Green, Hodge Hill, Shard End or Washwood Heath
Funding Opportunities
Community Chest
For 2013/14 all wards in the city receive a Community Chest allocation of £50,000. This allocation enables the wards to fund schemes which support ward and neighbourhood working or contribute to extending community engagement, cohesion and empowerment.
Projects supported through this fund must also demonstrate that they support one or more of the outcomes in Birmingham's Council Plan 2008 -2013 and Birmingham's Community Strategy 2026.
Generally, any properly constituted organisation may submit a project proposal. You should first talk with the District Ward Support Officer to find out what outcomes and locally identified priorities the Ward or District Committee is likely to support and the money that it has available. Please contact Tracey Arthurs on 0121 303 9282 or email email@example.com for details of current funding opportunities.
Community First
The Community First Programme is a national programme which runs over four years until 2015. Twenty-seven Wards in Birmingham have funding through Community First. The programme is independent of Birmingham City Council and is managed by a national organisation, appointed by the Government, called Community Development Foundation. Community First funding is distributed by a Community First Panel established in the Ward. A list of Community First Panels along with other information about this programme and how to access funding is available on the Community Development Foundation Website.
There may be a number of other funding opportunities available, such as Big Lottery Funding for example. Your District Ward Support Officer Tracey Arthurs can give you more information on this. Call her on 0121 303 9282 or email her at email@example.com.
Expressions of Interest for a Community Asset Transfer - Hutton Hall
Third sector organisations are invited to make expressions of interest and provide a business case for the Community Asset transfer of Hutton Hall, Herrick Road, Washwood Heath, B8 1NT.
What do you think?
We want to know what you think about the services we deliver to you. You can give us Your Views online.

subset: commoncrawl


text:
Jewelry Travel Case
A Gem Of a Travel Case To Safely Carry Treasures While Traveling
Jewelry Travel Case
A Gem Of a Travel Case To Safely Carry Treasures While Traveling
As seen in O, The Oprah Magazine, this origami-inspired jewelry travel case is fitted with 4 double-side zippered pockets, 2 single-end zippered pockets, and 6 removable pouches, each designed to carry, protect, and organize jewelry, valuables, and personal items while traveling or to store small valuables at home. Compact in design, this soft, satiny fabric case also features a padded ring strap, 2 middle straps to secure the removable pouches, and an expandable bottom. 3½"Hx5½"Wx5"D. Polyester satin. Spot clean.
- 4 double side pockets
- 2 single end pockets
- 6 removable pouches and 1 padded ring strap
- Compact and packable
- As seen in O, The Oprah Magazine
This artful travel organizer keeps jewelry safe and organized at home or on the go.
Jewelry Travel Case
Polyester satin, Clear PVC, Metal.
Wipe clean with a damp cloth.
Manufactured In: China
Material - Country Of Origin: China


text:
SUPERSEDED (see Active link, below)
Active (view current version of standard)
1. Scope
1.1 This specification covers wrought carbon steel and alloy steel fittings of seamless and welded construction, covered by the latest revision of ASME B16.9, ASME B16.11, MSS-SP-79, and MSS SP-95. Fittings differing from these ASME and MSSVF standards shall be furnished in accordance with Supplementary Requirement S58 of Specification A 960/A 960M. These fittings are for use in pressure piping and pressure vessel service at low temperatures.
1.2 Optional supplementary requirements are provided for fittings where a greater degree of examination is desired. When desired, one or more of these supplementary requirements shall be specified in the order.
1.3 This specification is expressed in both inch-pound units and in SI units. However, unless the order specifies the applicable "M" specification designation (SI units), the material shall be furnished to inch-pound units.
1.4 The values stated in either inch-pound units or SI units are to be regarded separately as standard. Within the text, the SI units are shown in brackets. The values stated in each system are not exact equivalents; therefore, each system must be used independently of the other.
2. Referenced Documents (purchase separately) The documents listed below are referenced within the subject standard but are not provided as part of the standard.
ASTM Standards
A960/A960M Specification for Common Requirements for Wrought Steel Piping Fittings
ICS Code
ICS Number Code 23.040.40 (Metal fittings)
UNSPSC Code
UNSPSC Code 40170000(Pipe piping and pipe fittings)
ASTM International is a member of CrossRef.


text:
Wishful Birthday Bear
(1 review)
rollover to zoom
- Contents
- Details
- Reviews
Send a cuddle with your cookies! Our 15" plush bear is dressed for the party, arriving with 4 original cookies and two frosted cookies.
**Due to our dough mixing process, all of our products may have come in contact with nut oils.
- Nibblers® bite-sized cookies come in an assortment of our most popular flavors.
- Nibblers® bite-sized cookies come packaged in half dozens in a special wrapper designed to preserve out-of-the-oven freshness since no preservatives are used.
- Cookies taste best when eaten the same day they are received.
- Brownies are best when refrigerated or frozen.
- Some tips if you have to save some cookies for later: never refrigerate - they dry out, store in an airtight container with a piece of white bread, may be frozen in an airtight bag.
- Thawed cookies can be warmed in the microwave for up to 10 seconds or a 375 degree oven for 1-2 minutes.
- Frozen cookies can be warmed in the microwave for 20-30 seconds or a 375 degree oven for 1-3 minutes.
1 customer review has been submitted for the Wishful Birthday Bear.
Overall Rating:(5.0 of 5)
Granddaughter(05/31/2011)When this was delivered to my 3 year old Granddaughter she grabbed the bear and kissed it and said this is from my NANA and is wrapped with her love. She now carries the bear everywhere, It is just adorable, this is not a small bear it is medium sized.. Very good price for what is recieved.
IMPORTANT NOTICE: We apologize for the inconvenience but this gift is not currently active.
May we suggest another product you may like:
Trick-Or-Treat Treasure Box
Birthday Balloons Big Cookie Cake
Large Give Thanks Tin
($39.99 - $49.99)
Twelve Inch Cookie Cake


text:
Beau Bennett is dealing with a lower-body injury.
Nathan Horton is out indefinitely with a back injury that has bothered him for most of the summer.
Anthony Mantha will be sidelined for six-to-eight weeks due to a fractured right tibia.
Evgeni Malkin has a minor undisclosed injury.
Sidney Crosby will miss the start of training camp due to an undisclosed injury.
Teemu Selanne's new biography revealed that he didn't see eye-to-eye with Ducks coach Bruce Boudreau.
Ryan Johansen, a restricted free agent who led the Blue Jackets in scoring last season, has left Columbus on the eve of training camp, unhappy with the club's contract offer to him - but coach Todd Richards insists he won't let the matter distract his team.
Ilya Bryzgalov has accepted a professional tryout with the Minnesota Wild and he will be at camp.
Minnesota has announced that Josh Harding has a fractured right foot.
According to TSN's Bob McKenzie, Josh Harding's ankle injury is "significant."
Columbus GM Jarmo Kekalainen isn't sure if Nathan Horton (back) will miss the start of the season.
Justin Braun has reached a five-year contract extension with the San Jose Sharks.


text:
Pleasant this weekend
Walking to work is not only good for your body; it may also benefit your psychological health, a new study from England suggests.
Trail-running inspires fun workouts for newbies, road racers, and the injury-prone.
Tour the world with the power of pedaling on these scenic bike routes.
Diseases, infections and dangers that could ruin your next hike.
California's iconic trees, the giant sequoias, may sail through the state's current extreme drought. The huge trees survived even drier conditions during their long lives, studies show. The oldest sequoias live for more than 3,000 years.
The U.S. National Park Service (NPS) turns 98 years old on Monday (Aug. 25), and to celebrate, the agency is throwing open the doors to all national parks, and inviting people to visit for free.
The most stunning campsites inside our nation's national parks.
Have a long weekend and a trusty bike? Then it's time to make your two-wheeled escape from crowded tourist hubs with these beautiful urban rides.
Dec 5, 2012; 5:00 AM ET Now that it's cold enough to hit the slopes, you may want to look more closely at what materials your winter sports gear is made of. As it turns out, not all waterproofing is created equal.


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|12 minutes
|Anne of Green Gables
|20 minutes
|Golfing (30+ golf courses)
|5 minutes +
|Victoria Park & Ocean Boardwalk
|Walking dist.
|Shops & Restaurants
|Walking dist.
|January - May 31, 2010
|Based upon double occupancy
|June 1 - September , 2010
|Based upon double occupancy
|October 1 - December 31, 2010
|Based upon double occupancy
Obanbrae Farm Bed & Breakfast
Charlottetown, Prince Edward Island Bed & Breakfasts
Enjoy Island hospitality. Central location for touring Island. City close-by, plus beaches, golfing, harness racing, casino, and great dining . Two comfortable guest rooms with shared washroom. Kitchen privileges. Beef cattle and donkey farm....
Starting at 50 Per Night
Be My Guest
Charlottetown, Prince Edward Island Bed & Breakfasts
Pull up a chair and relax in our open area two bedroom home. The bedrooms feature queen size beds, and a large three piece bath. Our rates include breakfast...
Starting at 79 Per Night
Relax at Firedance Country Inn Bed & Breakfast
Charlottetown, Prince Edward Island Bed & Breakfasts
Relax and rejuvenate in our serene country getaway. Romantic weekends, honeymoons, family adventure; Firedance is the place to have them. Centrally located, stay with us and visit all of PEI from one base!...
Starting at 90 Per Night
Ozendyke B&B . . . the place to be
Charlottetown, Prince Edward Island Bed & Breakfasts
Now for S A L E A very old large historic farm house, conveniently situated between the Confederation Bridge, Cavendish and Charlottetown. Canada Select Approved....
Starting at 65 Per Night
Trailside Bed & Breakfast (on Confederation Trail)
Charlottetown, Prince Edward Island Bed & Breakfasts
Trailside is on Route 2, 6k from downtown Charlottetown. 5/15/30 minutes to shopping/beaches/Anne of GG Cavendish. The Confederation Bike Trail borders our property. Bus to downtown at the door. Plenty of parking, Wifi, gardens & breakfast. 2.5 star...
Slumber Westhill
Charlottetown, Prince Edward Island Bed & Breakfasts
Our Bed & Breakfast is strategically located in a quiet subdivision in what was formerly known as West Royalty and is near most ammenities and is only minutes away from most tourist destinations....
Rates from 69 Per Night
Charlotte's Rose Inn
Charlottetown, Prince Edward Island Bed & Breakfasts
This Victorian home constructed in 1884 has been restored and furnished to provide modern amenities yet still reflect its original character. We are located only two blocks from the centre of historic Charlottetown....
Starting at 165 Per Night
Colonial Charm Inn Bed & Breakfast
Charlottetown, Prince Edward Island Bed & Breakfasts
4 Star Bed and Breakfast in historic downtown Charlottetown. Spacious suites with balconies, ensuite bathrooms, business centre, phone lines, wireless high speed connection and a full breakfast each morning. Let us make your stay memorable!...
$125 Per Night
Bird's Eye View B & B
Charlottetown, Prince Edward Island Bed & Breakfasts
Amenities in All Rooms Each room has: * En-suite bathroom with bath and overhead shower * Hairdryer * Queen size bed with posturepedic mattress * Lots of pillows and luxurious duvet * Comfortable seating area for 2 peopl...
109 Per Night
Sunrise & sunset water views at Johnson Shore Inn
Souris, Prince Edward Island Bed & Breakfasts
A four star inn perched on a red cliff overlooking the Gulf of St. Lawrence Full breakfast is included with the room and dinner is available. All rooms have water views and are en-suite. Relax and unwind or explore. You'll be comfortable on the edge!...
Starting at 100 Per Night
MacQueen's Island Tours
Charlottetown, Prince Edward Island Bike Tours
Supported Independent Bicycle tours of PEI includes B&Bs/Inns w/breakfast, quality hybrid bicycle, luggage transfers, maps, route cards, emergency repair service - everything you need for a carefree holiday. PEI's only tour company run by Islanders....
Outside Expeditions - Prince Edward Island
Charlottetown, Prince Edward Island Kayaking & Canoeing
Outside Expeditions has offered kayak and bike tours, as well as canoe, kayak and bike rentals from 2 Island locations since 1993....
Starting at 39 Per Event
Parasailing - The Pier
Cavendish, Prince Edward Island Parasailing
Prince Edward Island Water Sports: Para sailing, Sea-Doo rentals and Kayaking. Restaurant on site. Para sailing features a dry take-off and landing and 3 different rides to choose from. Sea-Doo`s and Kayaks rent by the hour....
Starting at 109 Per Night
The Studio Gallery
Charlottetown, Prince Edward Island Artisan & Trade Workshops
A summer gallery and features the etching studio of Doreen Foster as well as Prince Edward Island fine art by P. John Burden, Sylvia Ridgway, & Henry Dunsmore and the ceramics of Jamie Germaine and Emily Dunsmore....
Experience PEI-unique hands-on learning adventures
Charlottetown, Prince Edward Island Cultural Experience
Prince Edward Island is a wonderful place to spend your vacation but at Experience PEI we believe you're looking for more. That's why we created unique hands on opportunities to go out with oyster/lobsterman, make chocolates, dig clams or sandsculpt...
Experience PEI
Charlottetown, Prince Edward Island Sight-Seeing Tours
We offer experiential activities for tourists so that they can actually experience the true Prince Edward Island experience!...
The Bottle Houses/Maisons de Bouteilles
Summerside, Prince Edward Island Sight-Seeing Tours
3 lifesize structures made of over 25 000 recycled glass bottles surrounded by serene and colourful flower gardens, truly a paradise on earth where nature is at its best, along the shores of beautiful Northumberland Strait. Glassy boutique. Unique....
Bideford Parsonage Museum
West, Prince Edward Island Museums
This Designated Heritage Property was built in 1878 as a private residence. In 1884 it was sold to the Methodist Church as their Parsonage. Author L.M. Montgomery lived here during 1894-95 when she first taught school in the Bideford #6 School....
Affordable Rates from 5 Per Person
Holland Grove House
Charlottetown, Prince Edward Island Hotels & Resorts
Our beautifully restored 1850's home has all the modern convienences with all the charm of an older home. Featuring fourteen unique suites featuring hardwood floor, fireplace, kitchenette, four poster beds and air jet tubs. ...
169 Per Night
The Hotel On Pownal
Charlottetown, Prince Edward Island Hotels & Resorts
The newly renovated Hotel on Pownal offers visitors 45 guest rooms and suites, ranging from traditional rooms with two double beds to two-bedroom suites. We will happily assist you in planning your vacation prior to or during your stay....
Starting at 149 Per Night
|Link Code


text:
An alligator hunter took home a near record-setting reptile from Lake Maggiore in St. Petersburg: a 13-foot, 9-inch gator that weighed 770 pounds.
Jovan Johannessen of Clearwater said he spotted the alligator in the residential lake nearly three months ago and was waiting until hunting season to try to track it down.
"I got out of work early [Wednesday], drove down to the lake and found him sitting right there next to the shore," said Johannessen, who has been hunting alligators for 10 years and said it was a struggle to catch the biggest one he's seen in the wild. "It was just an endurance battle, a tug-of-war back and forth."
Johannessen and his father eventually won the fight after 45 minutes.
According to the Fish and Wildlife Conservation Commission, the gator caught by Johannessen is the second largest on record in the Bay area and eighth biggest in the state. The one topping the list was captured in Brevard County in 2010 and measured 14 feet, 3 inches.
Alligator hunting season in Florida started in mid-August and has already produced some big reptiles. Two Lakeland men, Harris Woodsby and Matt Fellows, took home one from the Kissimmee River earlier this month that was 12 and a half feet long.
"We think that we might not ever be able to beat it," Woodsby said. "We love that we got one that big because it's so rare that a lot people just don't ever get gators that big."
Gary Morse, an FWC spokesman, said finding gators this big doesn't happen often and catching one in a residential body of water like Lake Maggiore is also uncommon.
"Of the alligators caught during alligator-hunting season, anything 12-feet and above is somewhat rare," he said.
Johannessen said he doubts he'll ever catch another one as big as the one he caught Wednesday, but that won't stop him from trying.
"That's the whole goal of it is bigger is better," he said. "I hope I can get that number one spot one year."
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text:
I'm glad everyone was okay through the storms! We got a severe thunderstorm last night and we're supposed to get more today.
I may be screwed out of another semester... 2 more years to finish my degree instead of just a year-year1/2.
I just took a placement test, since my college goes by ACT scores and I took SATs..
The scores are based out of 100... I got a 98 in reading, 93 in writing....
To be in my bio class this fall I needed a 45 in the math section, and I got a 28...
Ash that sucks.
I had to take a refresher math course when I re-entered college. It didn't delay my degree though because I had so many other courses that I had to take as prerequisites for my degree program anyway.
Ash: http://www.satfreepractice.com/. I sure do wish there was such a thing as the internet when I was prepping for exams. It looks like that site is full of Math tutorials.
Bridget, I'm sorry that you had that moment with Savana last night. It does sound to me like the two of you have a wonderful chemistry, and she says such insightful things that it makes me want to follow her story as she blossoms into a young woman. Perhaps there are kiddie meditation techniques you could teach her to focus her on happy things. Molly (Abbeysmom) would be the expert there, I'm sure.
Mandy, thank you for the compliment on the photos. I feel like they're getting outdated already, because they were from October. The avatar pic has been my FB profile pic for ages, and I feel like I really should change it now, but I am still attached to it. So I decided to use it on APA for just a little while. BTW, me changing my siggy & avatar was done within an hour of finding out I might be losing my contract ... on company time. LOL. It's kind of funny. That was like my one act of defiance for them deciding to let me go.
kate, I'm gonna be in Boston next week for my FIL/MIL's 50th anniversary. I actually looked up the dates of the NKOTBSB concert to see if I'd even be there at the same time, but the dates don't coincide. If it were affordable and while I were going to be there, I would have tried to go with you, even if I don't know any of their songs. Do they sing "The Right Stuff"? I know that song.
I did talk to DH last night about my thoughts on his work inefficiencies. I told him we need to reduce the number of hours that Bodhi is in his preschool to save money. I think it really drove the point home when I pointed out the number of hours Bodhi is at school vs. the number of hours DH actually bills. At first he tried to make a case for how he "needed" those extra hours. Then I pointed out to him if he genuinely needed that type of overhead - even 1 extra hour for every hour he bills, and typically more - then he'll never reach the capacity he needs to make the kind of income that could really help us out as a family. I ended the talk positively by telling him I didn't think it was hopeless, and that I actually thought he could find greater efficiencies AND more work was going to come in.
He tried to point out that all these guys were going to hire him on all these different jobs (which he's been saying for months now). And I said, OK, let's scale back and manage to the worse case scenario, not the best case scenario. We can always adjust when the work comes in because Bodhi's school is that flexible.
He agreed with me, but he said it kept him up at night for the 2nd time in a row. He requested that I not bring heavy stuff up before going to bed because he stays up thinking about it at night.
One other thought...if he's devoting that time to work he's actually doing, can't he bill for more hours?
Ashley, you can practice enough at home to retake the test. When I took the GRE it had been about 12 years since I'd taken a math class. I got one of those practice books with a CD rom of practice tests to take on the computer. When I first took the practice tests, I got something like a 350 (GRE is scored like the SAT with 800 being the top score). I worked myself through the workbook and practiced and practiced, and when I took the actual test I got a 650. So you can definitely bring your skills up yourself at home. Although I think the practice tests were harder than the actual test in the case of the GRE, but that was still a big difference. Definitely try the site Myles linked to.
Me (40) DH (47) & furbabies * m/c 7/08 4/12 11/12
kate, it had totally occurred to me that we would be in the same state. I thought you lived somewhere 2 hours West of Boston for some reason, so I figured I could only meet up with you if you would come into the city for the concert. We usually stay in Framingham with SIL, but this time, it'll be Methuen with BIL.
Both DH & I just read this article about New Bedford, MA and were interested enough by it to want to take a day trip there. Are you anywhere near there? A meetup would be fun, and probably a nice break from DH's 7 siblings, 17 nephews/nieces, etc.
I just ran into an old acquaintance from high school. I'm sorta ashamed to admit I hung out with her simply because she had access to alcohol. I never liked her, and she didn't turn out to much. Honestly, I thought she looked like a meth addict, and she was trying to tell me all about what was going on in people's lives. People that were friends of hers and I could barely remember their names, but couldn't place their faces. I was embarrassed to be talking to her, and my girls were looking at me strangely. As soon as she walked away Bobbie asked me, "So, you're a gossip girl now?" They know that's not me. They couldn't believe I hung with her at all.
It's just so weird. We're 35 and she's talking about her friends, and not in a good way. It made me terribly uncomfortable.
heehee, here I am talking about her, so I guess it doesn't make me any better. My only excuse is that I really do put things here that I wouldn't share with anyone else. And you guys don't know her...so somehow that makes it better.
DBF and I went to a "concert" friday night. It was an all day thing, and each band got an hour set. We showed up at 8:20, and listened to three bands. The last band was actually a rap group, and one of the guys in it is his manager at work.
One of their songs was talking about riding through the streets of the town we live in. I was laughing my butt off so hard. Then everytime they yelled out "307!" (wyoming area code) I felt the urge to yell out "907!!" (alaska's area code)
anyways, I am listening to their cd right now, and they sounded a million times better in person. Which is pretty surprising.


text:
PCB New Product Introduction (NPI)
Achieve first-time-right designs that meet the most demanding manufacturing process rule-sets
Valor NPI products combine capabilities of design for manufacture (DFM) and new product introduction (NPI) to ensure smooth transition from PCB design to fabrication, assembly and test from any PCB design environment.
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- Automatic DFM analysis for new design versions with pinpointed manufacturing problems directly in the layout environment
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ODB++ Intelligent Data Format
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New product introduction (NPI) platform for DFM validation and manufacturing data preparation
Fabrication Preparation
Integrated fabrication preparation environment


text:
Product Recall: We are voluntarily recalling fewer than 8,000 cases of regular Kraft American Singles Pasteurized Prepared Cheese Productlimited to 4 SKUs on two "Best When Used By" dates of February 20, 2015 and February 21, 2015. Click Here.
HEAT oven to 350°F.
LINE 13x9-inch pan with foil, with ends of foil extending over sides. Spray foil with cooking spray.
MICROWAVE unsweetened chocolate and butter in large microwaveable bowl on HIGH 2 min. or until butter is melted; stir until chocolate is completely melted. Stir in sugar. Blend in eggs and vanilla. Add flour and flavored instant coffee; stir until well blended. Spread into prepared pan.
BAKE 30 to 35 min. or until toothpick inserted in center comes out with fudgy crumbs. (Do not overbake.) Cool completely. Use foil handles to remove brownie from pan; cut into shapes with 1-1/2-inch heart-shaped cookie cutter. (Reserve scraps for snacking or another use.) Melt semi-sweet chocolate as directed on package. Dip tops of brownie hearts in chocolate. Refrigerate until chocolate is firm.


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I know there's a frozen yogurt craze happening right now, but the original sweet treat to beat the heat (say that 5 times fast) is ice cream.
Those who haven't yet caught up to the fro-yo frenzy, will likely keep to their traditional two to three scoops of dairy, sugar and flavorings.
But like any other industry, there are new releases. The 10 best from the Huffington Post are listed hither.
Here are a couple of comments regarding the list.
1) Steve's Bklyn Blackout sounds AWESOME. Beer (especially stouts) can work extremely well in ice cream. (In fact, the photo above is of a Guinness Milk Chocolate Ice Cream).
2) Gelato is always great for both simple and innovative flavors. The pistachio one is simple, but the thing about gelato is that it's usually made extremely well.
3) Don't worry...there IS a Ben and Jerry's on the list.
4) Anything from Ohio I tend to be skeptical about, especially if it's named "The Buckeye State". But it actually sounds pretty good.
Go and search out some of these exciting, trendy flavors to mix up the monotony of your regular ice cream consumption.


text:
You are visiting our UK site. Click here to view our US site
Straight Ear Probe (BN5101)
Long octagonal shaped handle.
Size: 15cm x 2mm.
Weight (including packaging): 175g
Tax is not applicable to those living outside the European Economic Community. For more info click here.
99 in stock
Now: £4.95 (£5.94 inc. tax)
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Evening Reading: A Night Without the NetLast night I get home from work, flick on the TV, and get a "searching for satellite" message on the screen. "Hrmm" I think, "Well, no big deal. I'll just get on the Net, maybe stream the next episode of BSG on Netflix..." Uh, no, my Internet was out too. Suddenly, I felt like I'd entered the dark ages. Pretty amazing how completely I take these conveniences for granted now--and how dumbfounded their absence left me. Don't tell me those freaky sci-fi movies fueled by paranoid futurists are right!
Ah, who cares if they are so long as I've got more than thirteen channels of shit on the TV to choose from.
Here are the highlights from the Shack's feed today for you to chose from:
- BlizzCon 2010 Event Schedule
- Dragon Age: Origins Save File Imports 'The World' Into Dragon Age 2
- Deathspank Coming to PC Pct. 26; Mac OSX in the Works
- U.S. Military Stores Won't Sell Medal of Honor Despite 'Taliban' Name Change
- Drunk Hulk celebrates one year anniversary on twitter
- Flyer campaign at New Mexico State calls for "Sex Strike" against football players until they win a game
- Jersey Shore: the RPG
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About OpenBSD
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The OpenBSD project produces a FREE, multi-platform 4.4BSD-based UNIX-like operating system. Our efforts emphasize portability, standardization, correctness, proactive security and integrated cryptography. As an example of the effect OpenBSD has, the popular OpenSSH software comes from OpenBSD.
OpenBSD is freely available from our FTP/HTTP sites or as a 3 CD set.
The current release is OpenBSD 5.5 which was released May 1, 2014.
OpenBSD is developed entirely by volunteers. The project's development environment and developer events are funded through contributions collected by The OpenBSD Foundation. Contributions ensure that OpenBSD will remain a vibrant and free operating system.


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United States & Canada Customers: Call 1-800-813-6897
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Get the Tour Edge Bazooka HT Max-D Iron Set, and add the ultimate set of weapons to your bag. The new and improved head design combined with variable progression throughout the entire set make the Bazooka a remarkable set of irons. The set's progressive design can be seen in each iron's different blade length, face height, top line, offset, bounce, and MOI (Moment Of Inertia). This optimizes the club's performance in distance, trajectory, spin, bounce, forgiveness, and accuracy. The long irons (4-5) feature a wider, hybrid-like blade length, thicker sole, and progressive undercut cavity for greater forgiveness and higher-flying shots. The irons' larger top line, offset club head and minimal bounce inspire confidence even from the most difficult lie. The mid irons (6-7) feature a shorter blade length, less offset, more bounce and a smaller top line and sole for greater workability and shot-making. Finally, the scoring irons (8-PW) feature a smaller undercut cavity, the least offset, the most bounce and a slightly larger sole than the mid irons for shots that get up quickly and stick close to the pin. Advance your game with the progressive engineering of the Bazooka HT Max-D irons.
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follow the signs for the city centre and make your way towards the Roman theatre. We are situated 10 metres exactly from the Car Park entrance to the Roman Amphitheatre opposite the Tourist Police Information Office and the Philadelphia Police Headquarters.
Farah Hotel
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Sumer Promotion /Dead sea/ Petra
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Dead Sea- Petra 3 days- 2 nights ( 290$ ) Summer Promotion- (15.5-15.9.2011) Day 1: Meet & Assist at queen Alia Airport, transfer to Dead sea hotel , overnight. Day 2: After breakfast, transfer to the south of Jordan, Petra visit , then back ...
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A decent warm welcome from Nefertiti hotel.our hotel location situated between the old city of Amman an...
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Art Garfunkel Calls Relationship With Paul Simon 'Difficult'
Saturday, September 22, 2012
Art Garfunkel says that although there's still a strong bond with Paul Simon, their relationship isn't among the easiest. Garfunkel, who's playing a string of dates this fall in support of his new career-spanning compilation, The Singer, was asked by The Los Angeles Times about his relationship with Simon: "It's distant. I respect Paul as a wonderful, grounded papa, wonderful guitar player, old friend of mine who knows me better than anyone on Earth. Very funny man, and he's been cracking me up since junior high school. These are very valuable people in your life, but it's as if he's so special and so interesting that if I dial his number, I have to come with my A stuff just to call a friend."
He went on to say, "When we worked together, it wasn't that way. We had so much of the job at hand to keep us going. As time goes by, when I see Paul, there are wings in both of our spirits. He turns me on, I turn him on. There's a real Simon & Garfunkel third person that emerges. This is great fun, great fun. But he lives in Connecticut, he's raising his family; I'm in New York with my family. I don't know. It's probably my fault. I'm reclusive."
Although Simon has toured with Garfunkel several times since 1982, he adamantly refuses to record new music as Simon & Garfunkel. Garfunkel admitted, "That's a vision of a very, very exciting project that should be doable. This man has never stopped growing as a musician, nor have I. He's never stopped growing as an aware man, nor have I. We should be able to get it on with those facts, and yet it takes two to tango. You have to have two people who see it that way."
Art Garfunkel, like Paul Simon, has continued performing the duo's legendary hits during his solo shows. He says that he's yet to lose his passion for performing his signature tune, "Bridge Over Troubled Water" live in concert: "I do 'Bridge Over Troubled Water' in the same key I always did, and when I'm pumped and really in the mood, I kinda wanna take it higher than I ever used to. So, I'm here to say, as long as the fires are going inside; fire's fire, the life force is the life force. It does not age, it's a constant."
UPDATED: Art Garfunkel U.S. tour dates (subject to change):
October 5 - Morristown, NJ - Mayo Performing Arts Center
October 6 - Hazleton, PA - Alice Wiltsie Center For the Arts
October 11 - Tarrytown, NY - The Tarrytown Music Hall
October 12 - New Bedford, MA - Zeiterion Performing Arts Center
October 26 - Milwaukee, WI - Pabst Theater
October 27 - Minneapolis, MN - Pantages Theatre
November 2 - Catoosa, OK - The Joint at Hard Rock Casino / Tulsa
November 3 - Wichita, KS - Orpheum Theatre
November 24 - Englewood, NJ - Bergen Performing Arts Center
November 30 - Fort Worth, TX - Bass Performance Hall
December 1 - Skokie, IL - North Shore Center For The Performing Arts
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|Amount Per Serving
|% Daily Value
|Total Carbohydrates
|6 g
|0 g
|Vitamin B6 (as Pyridoxine HCL)
|20 mg
|Folate (Folic Acid)
|300 mcg
|Vitamin B12 (as Cyanocobalamin)
|120 mcg
|75 mg
|200 mg
|60 mg
|300 mg
|75 mg
|NO-XPLODE™'s Proprietary Blend
|19.6 g
|Advanced Strength & Performance Matrix
Modified Glucose Polymers (Maltodextrin), Beta-Alanine (CarnoSyn®), Di-Creatine-Malic Acid Interfusion, Betaine HCL, Sodium Bicarbonate, Creatine-Sodium Phosphate Matrix, Creatinol-O-Phosphate-Malic Acid Interfusion, Glycocyamine, Creatine Ethyl Ester HCL, Guanidino Propionic Acid, Cinnamon Extract (Bark) (Cinnulin PF®), Ketoisocaproate Potassium, Creatine-Alpha-Aminobutyric Acid Matrix (Creatine AAB™)
|Ener-Tropic Xplosion
L-Tyrosine, Taurine, Glucuronolactone, Methylxanthine (Caffeine), L-Tyrosine-Alpha Ketoglutaric Acid, MCT's (Medium Chain Triglycerides), Lesser Periwinkle (95% Vinpocetine, 98% Vinburnine [Whole Plant])
|NO Meta-Fusion
L-Arginine-Alpha Ketoglutaric Acid, L-Citrulline-Malic Acid Interfusion, L-Citrulline-Alpha Ketoglutaric Acid, L-Histidine-Alpha Ketoglutaric Acid, NAD (Nicotinamide Adenine Dinucleotide), Gynostemma (90% Gypenosides) (Leaves & Stem)
|Phospho-Electrolyte Composite
Di-Calcium Phosphate, Di-Potassium Phosphate, Di-Sodium Phosphate
|Glycerol Polymer Complex
Potassium Glycerophosphate, Magnesium Glycerophosphate, Glycerol Stearate
Allergen Information: Contains milk, coconut and soy (lecithin) ingredients.
NO-XPLODE™ is an extreme energy & performance igniter. Use caution when using with any other caffeinated products of if you are caffeine-sensitive. Always begin use with 1 scoop or less and assess your tolerance. It is not recommended that you consume more than 3 scoops per day. To avoid sleeplessness, do not consume within 4 hours of bedtime.
Before consuming NO-XPLODE, seek advice from a health care practitioner if you are unaware of your current health condition or have any pre-existing medical condition or if you are taking an MAO inhibitor or any other medication. Do not use if you are contemplating pregnancy, pregnant, nursing, prone to dehydration, or exposed to excessive heat. Reduce or discontinue use if sleeplessness, tremors, dizziness, nervousness, headaches, or heart palpitations occur. Please be aware this product contains the naturally occurring amino acid Beta-Alanine, which may cause a tingling skin sensation in some individuals similar to niacin flush. This effect should diminish after a few hours and should ultimately subside after days of continuous use. Although rare, individuals with the genetic disorder Hyper Beta-Alaninemia should not use this product. NO-XPLODE™ is only intended to be consumed by healthy adults 18-50 years of age. Too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat. Total caffeine from all sources is approximately 200mg per serving, which is equivalent to two cups of coffee.
Consumer is responsible for ensuring that his/her use of this product complies with the rules and regulations of all governing bodies or other entities having jurisdiction over any sport or athletic activity in which he/she participates as well as any career regulations. User assumes all risks, liabilities, and consequences related to any and all non-compliance issues that may arise by these entities.


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Slide 1
What Are Estrogens?
Estrogens are a family of related molecules that stimulate the development and maintenance of female characteristics and sexual reproduction.
The natural estrogens produced by women are steroid molecules, which means that they are derived from a particular type of molecular skeleton containing four rings of carbon atoms, giving the shape shown here. The most prevalent forms of human estrogen are estradiol and estrone. Both are produced and secreted by the ovaries, although estrone is also made in the adrenal glands and other organs.
Slide 2
Estrogen Targets Tissue
Estrogens are hormones, which means that they function as signaling molecules. A signaling molecule exerts its effects by traveling through the bloodstream and interacting with cells in a variety of target tissues.
The breast and the uterus, which play central roles in sexual reproduction, are two of the main targets of estrogen. In addition, estrogen molecules act on the brain, bone, liver, and heart.
Slide 3
Estrogen Receptors
Estrogens act on target tissues by binding to parts of cells called estrogen receptors.
An estrogen receptor is a protein molecule found inside those cells that are targets for estrogen action. Estrogen receptors contain a specific site to which only estrogens (or closely related molecules) can bind.
The target tissues affected by estrogen molecules all contain estrogen receptors; other organs and tissues in the body do not. Therefore, when estrogen molecules circulate in the bloodstream and move throughout the body, they exert effects only on cells that contain estrogen receptors.
Slide 4
Estrogen Receptors Trigger Gene Activation
Estrogen receptors normally reside in the cell's nucleus, along with DNA molecules.
In the absence of estrogen molecules, these estrogen receptors are inactive and have no influence on DNA (which contains the cell's genes). But when an estrogen molecule enters a cell and passes into the nucleus, the estrogen binds to its receptor, thereby causing the shape of the receptor to change. This estrogen-receptor complex then binds to specific DNA sites, called estrogen response elements, which are located near genes that are controlled by estrogen.
After it has become attached to estrogen response elements in DNA, this estrogen-receptor complex binds to coactivator proteins and more nearby genes become active. The active genes produce molecules of messenger RNA, which guide the synthesis of specific proteins. These proteins can then influence cell behavior in different ways, depending on the cell type involved.
Slide 5
Estrogen-Induced Changes in Cell Behavior
In liver cells, for example, estrogen alters the production of proteins that influence cholesterol levels in the blood.
Cholesterol does not readily dissolve in blood, so before it can be transported through the body, it first becomes bound to special cholesterol-carrying proteins called lipoproteins. The liver produces two such lipoproteins, called low-density lipoprotein (LDL) and high-density lipoprotein (HDL). LDL-cholesterol is considered to be the "bad" form of cholesterol because it tends to release cholesterol directly onto the inner wall of arteries, creating the "plaque" that can lead to heart disease. In contrast, HDL is considered to be the "good" form of cholesterol because it inhibits the formation of plaque and carries cholesterol away from the arteries and back to the liver.
The net effect of estrogen's action on liver cells is to increase the amount of HDL cholesterol and to decrease the amount of LDL cholesterol. By increasing HDL and decreasing LDL, estrogen helps to lower the risk of heart disease.
Slide 6
Estrogen-Induced Stimulation of Cell Proliferation
In some target tissues, the main effect of estrogen is to cause cells to grow and divide, a process called cell proliferation.
In breast tissue, for example, estrogen triggers the proliferation of cells lining the milk glands, thereby preparing the breast to produce milk if the woman should become pregnant.
Estrogen also promotes proliferation of the cells that form the inner lining, or endometrium, of the uterus, thereby preparing the uterus for possible implantation of an embryo. During a normal menstrual cycle, estrogen levels fall dramatically at the end of each cycle if pregnancy does not occur. As a result, the endometrium disintegrates and is shed from the uterus and vagina in a bleeding process called menstruation.
Slide 7
Estrogen and Cancer
Paradoxically, estrogen can be both a beneficial and a harmful molecule.
The main beneficial effects of estrogen include its roles in
- programming the breast and uterus for sexual reproduction,
- controlling cholesterol production in ways that limit the buildup of plaque in the coronary arteries, and
- preserving bone strength by helping to maintain the proper balance between bone buildup and breakdown.
Unfortunately, in addition to these important beneficial effects, estrogen can also be harmful. The most serious problem arises from the ability of estrogen to promote the proliferation of cells in the breast and uterus. Although this ability to stimulate cell proliferation is one of estrogen's normal roles, it can also increase a woman's chance of developing breast or uterine cancer.
Slide 8
Estrogen and Breast Cancer
During each menstrual cycle, estrogen normally triggers the proliferation of cells that form the inner lining of the milk glands in the breast.
If pregnancy does not occur, estrogen levels fall dramatically at the end of each monthly menstrual cycle. In the absence of high estrogen levels, those milk gland cells that have proliferated in any given month will deteriorate and die, followed by a similar cycle of cell proliferation and cell death the following month. For the average woman, this means hundreds of cycles of breast cell division and cell death repeated over a span of roughly 40 years, from puberty to menopause.
But how do these estrogen-induced cycles of breast cell proliferation increase the risk of developing cancer?
Slide 9
Cancer Arises from DNA Mutations in Cells
Cancer is caused by DNA damage (i.e., mutations) in genes that regulate cell growth and division.
Some mutations are inherited, while others are caused by exposure to radiation or to mutation-inducing chemicals such as those found in cigarette smoke. Mutations also can occur spontaneously as a result of mistakes that are made when a cell duplicates its DNA molecules prior to cell division.
When cells acquire mutations in specific genes that control proliferation, such as proto-oncogenes or tumor suppressor genes, these changes are copied with each new generation of cells. Later, more mutations in these altered cells can lead to uncontrolled proliferation and the onset of cancer. (For more information on how gene mutations cause cancer, see Understanding Cancer.)
Slide 10
Estrogen-Induced Proliferation of Existing Mutant Cells
Although estrogen does not appear to directly cause the DNA mutations that trigger the development of human cancer, estrogen does stimulate cell proliferation.
Therefore, if breast cells already possess a DNA mutation that increases the risk of developing cancer, these cells will proliferate (along with normal breast cells) in response to estrogen stimulation. The result will be an increase in the total number of mutant cells, any of which might thereafter acquire the additional mutations that lead to uncontrolled proliferation and the onset of cancer.
In other words, estrogen-induced cell production leads to an increase in the total number of mutant cells that exist. These cells are at increased risk of becoming cancerous, so the chances that cancer may actually develop are increased.
Slide 11
Estrogen-Induced Proliferation and Spontaneous New Mutations
Even in women who do not have any mutant breast cells, estrogen-induced proliferation of normal breast cells may still increase the risk of developing cancer.
The reason involves DNA. A cell must duplicate its DNA molecules prior to each cell division, thereby ensuring that the two new cells resulting from the process of cell division each receive one complete set of DNA molecules. But the process of DNA duplication occasionally makes mistakes, so the resulting DNA copies may contain a small number of errors (i.e., mutations). If one of these spontaneous mutations occurs in a gene that controls cell growth and division, it could lead to the development of cancer.
Proliferation of normal cells from exposure to estrogen creates a vulnerability to spontaneous mutations, some of which might represent a first step on the pathway to cancer.
Slide 12
Estrogen and Uterine Cancer
In the uterus, estrogen triggers the proliferation of endometrial-lining cells during each month of the menstrual cycle, followed by death of these cells during menstruation. Over a span of 40 years, from puberty to menopause, hundreds of cycles of cell division and cell death will occur.
These repeated cycles of estrogen-induced cell division tend to increase the risk of developing cancer in the same two ways as in the breast: Estrogen can stimulate the division of uterine cells that already have DNA mutations, and it also increases the chances of developing new, spontaneous mutations when estrogen stimulates cell proliferation. Whether the mutations are inherited or spontaneous, estrogen-driven proliferation will increase the number of these altered cells that can ultimately lead to the development of uterine cancer.
Slide 13
Since estrogen can promote the development of cancer in the breast and uterus, it seems logical to postulate that substances that block the action of estrogen might be helpful in preventing or treating these two types of cancer.
This rationale has led scientists to work on the development of "antiestrogen" drugs that can block the action of estrogens and thereby interfere with, or even prevent, the proliferation of breast and uterine cancer cells. Antiestrogens work by binding to estrogen receptors so that the estrogen molecules themselves cannot bind to those receptors. This also blocks estrogen from activating genes for specific growth-promoting proteins.
Slide 14
In working on the development of antiestrogens, scientists have made a somewhat surprising discovery. Some drugs that block the action of estrogen in certain tissues actually can mimic the action of estrogen in other tissues.
Such selectivity is made possible by the fact that the estrogen receptors of different target tissues vary in chemical structure. These differences allow estrogen-like drugs to interact in different ways with the estrogen receptors of different tissues. Such drugs are called selective estrogen receptor modulators, or SERMs, because they selectively stimulate or inhibit the estrogen receptors of different target tissues. For example, a SERM might inhibit the estrogen receptor found in breast cells but activate the estrogen receptor present in uterine endometrial cells. A SERM of this type would inhibit cell proliferation in breast cells, but stimulate the proliferation of uterine endometrial cells.
Slide 15
Tamoxifen and Cancer
The first SERM to be investigated extensively for its anticancer properties is a drug called tamoxifen (Nolvadex®).
Tamoxifen blocks the action of estrogen in breast tissue by binding to the estrogen receptors of breast cells, thereby preventing estrogen molecules from binding to these receptors. But unlike what occurs when estrogen binds to its receptor, tamoxifen binds but does not change the receptor's shape, so coactivators are unable to bind. As a result, the genes that stimulate cell proliferation cannot be activated.
By interfering with estrogen receptors in this way, tamoxifen blocks the ability of estrogen to stimulate the proliferation of breast cells.
Slide 16
Tamoxifen and Breast Cancer Treatment
In women who have breast cancer, proliferation of the breast cancer cells is often driven by estrogen, just as in the case of normal breast cells.
Since tamoxifen (Nolvadex®) can block the effects of estrogen on breast cells, scientists predicted that breast cancer could be treated by using tamoxifen to interfere with estrogen-induced cell proliferation. Based on encouraging results obtained in experimental trials, tamoxifen was first approved for such use in breast cancer treatment in the 1970s.
The first step in treating women with breast cancer is to surgically remove the cancer from the breast. It is difficult to be certain that every cancer cell has been removed at the time of surgery because some breast cancer cells could have spread to surrounding tissues or other organs prior to the operation. Therefore, women often receive some type of treatment after surgery (adjuvant therapy) to prevent the growth of any cancer cells that might remain in the body. Studies show that when tamoxifen is used for this purpose, the risk of cancer recurrence is reduced.
Slide 17
Aromatase Inhibitors
Many breast tumors are "estrogen sensitive," meaning the hormone estrogen helps them to grow. Aromatase inhibitors (AIs) can help block the growth of these tumors by lowering the amount of estrogen in the body.
Using a substance called aromatase, the ovaries and other tissues of the body produce estrogen. AIs do not block estrogen production by the ovaries, but they can block other tissues from making this hormone. That's why AIs are used mostly in women who have reached menopause, when the ovaries are no longer producing estrogen.
Tamoxifen (Nolvadex®), also helps to prevent the growth of estrogen-sensitive breast tumors, but it works differently from AIs. Whereas AIs reduce the amount of estrogen in the body, tamoxifen blocks a tumor's ability to use estrogen.
Currently, three AIs are approved by the U.S. Food and Drug Administration: anastrazole (Arimidex®), exemestane (Aromasin®), and letrozole (Femara®).
Slide 18
Estrogen Receptor-Negative Breast Cancer
Unlike normal breast cells, cancer cells arising in the breast do not always have receptors for estrogen.
Breast cancers that DO have estrogen receptors are said to be "estrogen receptor-positive," while those breast cancers that DO NOT possess estrogen receptors are "estrogen receptor-negative." In women with estrogen receptor-positive cancers, cancer cell growth is under the control of estrogen. Therefore, such cancers are often susceptible to treatment with tamoxifen (Nolvadex®), because tamoxifen works by blocking the interaction between estrogen and the estrogen receptor.
In contrast, the growth of estrogen receptor-negative cancer cells is not governed by estrogen and is not treated with tamoxifen.
Slide 19
Tamoxifen and Breast Cancer Prevention
Once tamoxifen (Nolvadex®) had been shown to reduce the risk of cancer reappearing after breast cancer surgery (in women with estrogen receptor-positive cancers), the question arose whether tamoxifen might also be helpful in preventing breast cancer in women at high risk of developing the disease.
The rationale for using tamoxifen to try to prevent breast cancer is similar to the rationale for using tamoxifen in breast cancer treatment. Estrogen-induced cycles of breast cell proliferation increase a woman's risk of developing breast cancer. Therefore, using tamoxifen to block the action of estrogen in the breast in healthy women might be expected to decrease a woman's chances of developing cancer in the future.
In 1992, the National Cancer Institute opened a study involving more than 13,000 healthy women considered to be at high risk for breast cancer based on their family or medical history. Half the women were given tamoxifen, while the other half were given a placebo. After 5 years, the group receiving tamoxifen had a lower rate of breast cancer.
Slide 20
Tamoxifen as a Cause of Uterine Cancer
Although tamoxifen (Nolvadex®) has been useful both in treating breast cancer patients and in decreasing the risk of getting breast cancer in women at high risk, it also has some serious side effects.
These side effects arise from the fact that while tamoxifen acts as an antiestrogen that blocks the effects of estrogen on breast cells, it mimics the actions of estrogen in other tissues such as the uterus. Its estrogen-like effects on the uterus stimulate proliferation of the uterine endometrium and increase the risk of uterine cancer.
Slide 21
The Need for Better SERMs
The fact that tamoxifen (Nolvadex®) blocks the action of estrogen in breast tissue while mimicking the action of estrogen in the uterus means that it functions as a SERM, selectively blocking or stimulating the estrogen receptors of different target tissues.
In addition to acting like estrogen in the uterus, tamoxifen resembles estrogen in its ability to lower LDL cholesterol levels. And in postmenopausal women, tamoxifen also resembles estrogen in its ability to preserve or increase bone density. Thus, aside from its tendency to increase the risk of uterine cancer, tamoxifen has a number of potentially beneficial properties.
As a result, scientists have been actively working on the development of other SERMs that might exhibit some of the beneficial properties of tamoxifen without sharing its potentially harmful effects.
Slide 22
Estrogen Replacement in Menopause
In addition to their relevance for cancer treatment and prevention, SERMs may also be potentially important for women who have passed through menopause and therefore produce little estrogen.
The lack of estrogen in postmenopausal women is linked to several health problems. For example, estrogen has positive effects on blood vessels and on bones. After menopause, though, women are at increased risk for heart disease and for osteoporosis, a weakening of the bones that causes them to become more vulnerable to fractures.
To counteract these potential problems, some postmenopausal women take hormone pills containing estrogen to strengthen bones and help control other menopausal symptoms. But, as a consequence, such women are subjecting themselves to the harmful effects of estrogen--namely, an increased risk for invasive breast cancer and uterine cancer.
Slide 23
Estrogen Plus Progestin Replacement
Studies carried out in the 1980s suggested that adding the hormone progesterone to estrogen could offset the increased risk of uterine cancer linked to the use of estrogen by itself. For this reason, hormone replacement therapy using estrogen plus progestin (a synthetic form of progesterone) became a common way of treating women with menopausal symptoms.
However, a study of 16,000 menopausal women carried out by the Women's Health Initiative was prematurely halted in 2002 when preliminary results indicated that the harm associated with this type of treatment outweighs the potential benefits. The major risks detected were an increased chance of developing invasive breast cancer, as well as an increased risk of strokes, heart attacks, and blood clots. While the data also revealed that hormone replacement with estrogen plus progestin lowered the risk of osteoporosis and colon cancer, these benefits were not considered to be sufficient to outweigh the other risks.
Slide 24
Searches for the Perfect SERM
Because of the potential cancer and cardiovascular risks inherent in hormone pills containing estrogen and progestin, scientists are working on the development of SERMs for postmenopausal women that can mimic the beneficial effects of estrogen without exerting any of its harmful effects.
The ideal drug, of course, would be a SERM exhibiting the positive effects of estrogen on bones, heart, and blood vessels without exhibiting the potentially harmful effects of estrogen on the breast and uterus.
Slide 25
Raloxifene and the Prevention of Osteoporosis
One SERM that may exhibit some of these properties is raloxifene (Evista®), a drug approved by the FDA in 1997 for preventing osteoporosis in postmenopausal women.
Raloxifene appears to function like estrogen in bone, acting to maintain bone strength and increase bone density. In addition, raloxifene also resembles estrogen in its ability to lower LDL cholesterol levels, thereby decreasing the risk of heart disease.
Although information on the long-term risks and benefits of raloxifene is limited compared to tamoxifen, preliminary evidence suggests that raloxifene may exert these beneficial effects on bones, heart, and blood vessels without increasing a woman's risk of developing cancer.
Slide 26
Raloxifene and Risk of Invasive Breast Cancer
In animal studies, raloxifene (Evista®) reduced the incidence of both breast and uterine cancer. And in preliminary human trials, raloxifene reduced the risk of breast cancer without the unwanted stimulation of uterine cell division that is exhibited by tamoxifen (Nolvadex®). As a result of these findings, the National Cancer Institute sponsored a human clinical study to directly compare the effects of tamoxifen and raloxifene in postmenopausal women at higher than average risk for this disease. The trial, named STAR (Study of Tamoxifen and Raloxifene), was begun in 1999 and is following more than 19,000 women for a period of 5 to 10 years.
Early STAR trial results show that raloxifene works as well as tamoxifen in reducing risk by about 50 percent for invasive breast cancer in postmenopausal women. And raloxifene has fewer side effects. Participants in STAR who were assigned to take raloxifene had 36 percent fewer uterine cancers and 29 percent fewer blood clots from that drug than did the women assigned to take tamoxifen.
On the other hand, tamoxifen reduces the incidence of lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) by half, while raloxifene did not have an effect on these diagnoses. (LCIS and DCIS are sometimes called noninvasive or stage 0 breast cancers.)
A woman can go to http://www.cancer.gov/bcrisktool/ to determine if her individual risk for invasive breast cancer is above average.


text:
A stunning cushion-cut gem of impressive proportions crowns an airy setting. You'll find yourself talking with your hands. See Details
Gemvara jewelry is truly personal: you design it, choosing gems and metals to celebrate your story, and we craft it just for you. We'd love to help you find your perfect piece! (more)What quality are your gemstones?
They are all-natural and hand selected fine quality. (more)


text:
Port Arthur fire dispatch tells 12News a man was taken to Christus Hospital St. Elizabeth in Beaumont Tuesday morning after his car rolled into a ditch.
The accident happened around 2:30 a.m. on Highway-73 near the Bob Bowers Civic Center.
The man was trapped inside the car when police and firefighters arrived. The jaws of life was used to free him.
Officials on the scene did not say the condition of the driver.


text:
David Ramsey
Gazette sports columnist David Ramsey offers opinions, views and thoughts on the world of sports
Ramsey: Too bad Phelps failed to learn from mistakeSep 30, 2014
Michael Phelps always says the right thing when he gets in trouble....Read More
Ramsey: Air Force defense silences critics, for nowSep 30, 2014
Last week, I wondered if Air Force's defense would finally stand up...Read More
Ramsey: Broncos face an enormous burden: Their 2013 seasonSep 9, 2014
The Denver Broncos have problem, and it's not going away. The problem...Read More
BYU's Max Hall, despised Air Force opponent, hits the skids in ArizonaSep 3, 2014
Former BYU quarterback Max Hall repeatedly shredded Air Force's...Read More
Ramsey: How much will Broncos miss Wes Welker?Sep 3, 2014
Easy answer to the Welker question: Not much. Welker's four-game...Read More
BYU's Max Hall, a despised Air Force opponent, on the skids in ArizonaSep 3, 2014
Former BYU quarterback Max Hall repeatedly shredded Air Force's...Read More
McElwain's lame sales pitch to his CSU football teamAug 29, 2014
Jim McElwain has been trying to tell his CSU Rams that they are...Read More
Ramsey: My phone conversation with Lance ArmstrongAug 27, 2014
When I went to my Twitter account on Wednesday morning, I encountered a...Read More
Ramsey: Peyton Manning sheds light on his true characterAug 24, 2014
Peyton Manning has sold himself to America as gentle, polite,kind,...Read More
Ramsey: Matt Carpenter has new routine for Pikes Peak MarathonAug 18, 2014
Matt Carpenter won the Pikes Peak Marathon 12 times and the Ascent six...Read More
No team on Air Force football schedule makes preseason top 25Aug 1, 2014
We're going to hear, as we always do, about the toughness of Air...Read More
Fisher DeBerry's intelligent, defiant attitude toward college football titansJul 30, 2014
Fisher DeBerry had a simple approach to every football game. The...Read More
Ramsey: LeBron James should not wear Jordan's No. 23Jul 29, 2014
LeBron James should not wear No. 23, a number that will forever be...Read More
Fisher DeBerry talks about New York City, America's GothamJul 28, 2014
Fisher DeBerry arrived in New York City in 2011 for an extended visit....Read More
Manchester United's van Gaal isn't fan of Colorado's heat and 'height'Jul 27, 2014
Louis van Gaal was not exactly the cheeriest guy after his team,...Read More
Bowlen's secret to success: He stayed out of the wayJul 23, 2014
Pat Bowlen is being celebrated today as he departs his day-to-day...Read More
Manning's 18 a surprising fourth in NFL jersey salesJul 21, 2014
Was surprised to see Broncos quarterback Peyton Manning in the fourth...Read More
Cowboys release Kyle Orton. Is he retiring? Or looking for a new gig?Jul 17, 2014
ORTON, back when he was an average QB for the Broncos SomeRead More
Ramsey: World Cup final proves soccer critics correct in one regardJul 14, 2014
Yes, Sunday's battle between Argentina and Germany could have used a...Read More
Cleveland Cavaliers have backup plan if LeBron spurns them, once againJul 10, 2014
From Yahoo's Adrian Wojnarowski, the premier source for NBA news:Read More
Ramsey: Is Ann Coulter funny? Is soccer boring? We wrestle with these vital questionsJul 7, 2014
First, let me say I almost always enjoy and appreciate and read and...Read More
Ramsey: Happy birthday to the Springs own Goose GossageJul 5, 2014
Richard "Goose" Gossage offers a lesson for all of us today, his...Read More
Ramsey: Happy birthday to Floyd Little, who made the Broncos legitJul 4, 2014
Happy birthday to Floyd Little. His arrival in Denver began the...Read More
Ramsey: The NBA's all-time top 22. Has LeBron climbed into the top 10?Jul 3, 2014
LeBron James is on the verge of invading the NBA's all-time top 10, but...Read More
Ramsey: Landon Donovan luches word raid on KlinsmannJul 3, 2014
The great soccer American soccer debate of 2014 was this: Should...Read More
What a great idea: The Luis Saurez – the bite king – bottle openerJul 1, 2014
A Chinese company has a fantastic idea. The company is selling Luis...Read More
What a great idea: The Luis Saurez - the bite king - bottle openerJul 1, 2014
A Chinese company has a fantastic idea. The company is selling Luis...Read More
Colorado great Chauncey Billups looks ready to exit NBAJun 30, 2014
Chauncey Billups, once one of the greatest high school players in...Read More
Football magazine predicts dire seasons for Air Force, CUJun 26, 2014
Athlon Magazine predicts Air Force will finish with a 4-8 overall record...Read More
Ramsey: Carmelo unpopular despite impressive season with KnicksJun 24, 2014
The biggest current mystery in American sport? Here's my...Read More
Ramsey: Ronaldo, Portugal earn tie with United States in fantastic soccer gameJun 23, 2014
RONALDO AND FRIEND I realize several million American soccer fans are...Read More
Ramsey: Former Air Force QB Jaleel Awini a strong Ghana soccer fanJun 17, 2014
Drove to Denver on Monday to watch the U.S. vs. Ghana World Cup game...Read More
Let's applaud U.S. senators for standing up to Redskins racist monikerMay 23, 2014
Thrilled to see United States senators standing up for what's...Read More
Knicks interested in Nuggets Brian Shaw for coaching vacancy. Why?May 21, 2014
Keep hearing the New York Knicks are looking at the Nuggets Brian Shaw...Read More
Air Force great Fisher DeBerry talks about the downside of textingMay 20, 2014
Fisher DeBerry talked a couple years ago about his philosophy of...Read More
Haviland, CC's new hockey coach, hopes to reach 20 wins ... next seasonMay 15, 2014
Mike Haviland is not a patient man., He looks at the Colorado College...Read More
Seahawks Richard Sherman sees need to change Redskins racist monikerMay 7, 2014
Sean Gregory of Time Magazine sat down with Seahawks cornerback Richard...Read More
Dan Reeves: Broncos underappreciated coaching heroMay 6, 2014
Dan Reeves is now best remembered as the Man Who Refused to Set John...Read More
Here's the most impressive statistic from John Elway's careerMay 3, 2014
John Elway earned five wins with only one loss in AFC title games. He...Read More
Mitchell High's Terry Miller belongs in CS Sports Hall of FameApr 25, 2014
TERRY MILLER in an undated photo Terry Miller should have been a member...Read More
To Redskins owner Danny Boy Snyder: Your racist nickname IS an issueApr 23, 2014
Danny Boy Snyder is such a riot. He's a rich guy who believes he...Read More
Wild's Nate Prosser, a former CC star, reacts to Scott Owens departureApr 19, 2014
Nate Prosser of the Minnesota Wild was asked for his reaction to Scott...Read More
What does Michael Phelps have left to prove in the pool?Apr 17, 2014
What does Michael Phelps have left to prove in the pool? Yes, you had...Read More
Eric Decker and the peril of purchasing Broncos jerseysApr 11, 2014
ERIC DECKER, who has departed our state In November, I spent a day...Read More
Air Force's Serratore not interested in vacant Colorado College jobApr 7, 2014
Air Force coach Frank Serratore said he is not interested in...Read More
Ruins and Colorado College hockey and Air Force footballApr 2, 2014
Last week, I described the Colorado College hockey program as...Read More
Broncos make big mistake, allow Moreno to run away to MiamiMar 27, 2014
Anyone who catches passes or runs with the football on the...Read More
Reggie Jackson, former Palmer High superstar, flirts with NBA stardomMar 25, 2014
One thing stands between Reggie Jackson and NBA stardom. His shooting...Read More
Want to watch the birth of Eric Decker's daughter?Mar 18, 2014
ERIC DECKER, father Neither do I. But we might get the...Read More
Is Champ Bailey the Broncos all-time greatest defensive player?Mar 7, 2014
THE CHAMP RICH "TOMBSTONE" JACKSON ...Read More
Meet the Princess of Wales who makes ridiculous ice skating accusationFeb 19, 2014
Virtue and Moir, silver medalists Meet Canadian journalist Rosie...Read More
Big (Smelly) Euro Dude and other not-so-fun slices of the Olympic rideFeb 18, 2014
Friends and people I've just met often ask about my Olympic...Read More
A visit to a typical, down-home Russian dinerFeb 15, 2014
Many of my sports writing friends seek to recreate home when they travel...Read More
Russians dislike the word "cold." I'm not sure whyFeb 14, 2014
Have talked with a few dozen Russians during my time here in Sochi....Read More
A moment of silence for the fallen BroncosFeb 12, 2014
Sat down last Monday on a flight from Baltimore to Denver. The flight...Read More
Most Russian cyclists don't even bother to lock their bikes. Why?Feb 11, 2014
I'm a devoted cyclist. When walking past a bike rack, I always...Read More
Putin's love life slightly more interesting than the lives of our recent leadersFeb 10, 2014
MR. PUTIN AND HIS LADY FRIEND In America, we're on a two-president...Read More
Thoughts on stray dogs in SochiFeb 6, 2014
SOCHI, Russia – When a few thousand journalists descend on any...Read More
Redskins honor Native Americans? How can this sorry franchise honor anyone?Feb 1, 2014
NEW YORK -NFL commissioner Roger Goodell is taking...Read More
Moreno should be Broncos top free-agent priorityJan 31, 2014
NEW YORK – When looking for the top priority...Read More
Broncos Welker fires back at Patriots Belichick, AKA The Evil GeniusJan 30, 2014
BILL BELICHICK. He's always grumpy. Wes Welker spoke...Read More
Broncos playoff wins: Manning 2, Tebow 1Jan 28, 2014
For several months, I heard often from the most fanatic fan base...Read More
The Seahawks Richard Sherman and the value of American public conversationJan 25, 2014
RICHARD SHERMAN OFFERS ENCOURAGING WORDS (I'm sure) TO TOM BRADY...Read More
Broncos 38, Patriots 35. That's my prediction. What's yours?Jan 18, 2014
ERIC DECKER Sunday will not be a defensive classic. Two of the finest...Read More
The truth about Peyton Manning and Bud LightJan 15, 2014
Peyton Manning recently scandalized those in Our Great...Read More
Patriots win, but is there celebrating in the streets? Ah, noJan 12, 2014
BOSTON – The Patriots defeated the Colts on Saturday night. It was...Read More
A star is born? Gracie Gold dazzles at skating championshipsJan 10, 2014
GRACIE GOLD BOSTON – The crowd at TD Garden on the edge of...Read More
Broncos extremely fortunate to miss Andrew Luck and his blazing ColtsJan 6, 2014
PHILIP RIVERS Denver faces a complicated challenge Sunday against the...Read More
Bears make big mistake, place their future in Jay Cutler's erratic handsJan 2, 2014
The Chicago Bears have placed their future in the shaky hands of...Read More
What's the point of 'hating' the Oakland Raiders?Dec 30, 2013
TED HENDRICKS AND GEORGE BLANDA PLAYED FOR RAIDERS TEAMS THAT ACTUALLY...Read More
Offense dominates current NFL: Just look at difference between '77 Broncos and '13 BroncosDec 26, 2013
In 1977, the Denver Broncos marched to the Super Bowl while averaging...Read More
Army searches, most likely in vain, for a coach to revive its fallen football programDec 19, 2013
Army boasts a sensational football past, but we all know the most...Read More
Palmer's Reggie Jackson can win NBA title in Oklahoma; In Colorado?Dec 18, 2013
Strong column in today's Gazette by my colleague Paul Klee about...Read More
What? Broncos crawl to 18 yards rushing against ChargersDec 13, 2013
As the Broncos crash back to earth after Thursday's 27-20 loss to...Read More
Former Broncos great Floyd Little praises current great Peyton ManningDec 11, 2013
Floyd Little was, for a brief time, the Denver Broncos. In the early...Read More
Hans Mueh speaks forcefully in support of embattled Troy CalhounDec 6, 2013
Troy Calhoun just lost 10 games. He has not lost the support of athletic...Read More
Carmelo Anthony is no Kobe BryantDec 2, 2013
Watched Carmelo Anthony and the New York Knicks find a way to lose on...Read More
Carmelo Anthony is no Kobe BryantDec 2, 2013
Watched Carmelo Anthony and the New York Knicks find a way to lose on...Read More
Air Force's Troy Calhoun gets emotional, but this is emotion Troy Calhoun-styleNov 22, 2013
News flash: Air Force's Troy Calhoun showed emotion during his...Read More
How many Air Force fans will brave Thursday's brutal weather?Nov 21, 2013
As the weather forecast worsens, the sports question of the week becomes...Read More
Air Force's favorite sports team? Torf says it's hockey, hands downNov 20, 2013
A few minutes after stifling Colorado College, goalie Jason Torf told me...Read More
Air Force football fans should expect rugged battle Friday in New MexicoNov 8, 2013
Yes, Air Force has dominated New Mexico in recent seasons. In four...Read More
Cycling's disgraced legend Lance Armstrong and his creepy supportersNov 4, 2013
Lance Armstrong has lived one of those strange American lives. Once he...Read More
Will new coach Brian Shaw find success this season with Nuggets? (No.)Nov 1, 2013
Brian Shaw is preaching a tougher, slower philosophy with the Denver...Read More
Wait a minute: Words of caution for joyful Avs hockey fansOct 31, 2013
Suddenly, the Colorado Avalanche is relevant again after spending the...Read More
Farewell to Allen Iverson. Former Denver Nugget revolutionized basketball, for better and for worseOct 30, 2013
Allen Iverson is both overrated and underrated. He is overrated as a...Read More
Bronco Ronnie Hillman's career now in severe jeopardy because of fumblesOct 21, 2013
It's been lonely. For months, I've been one of the three of...Read More
Irsay's remarks about Manning aren't 'cheap.' Irsay's remarks are the truthOct 16, 2013
Colts owner Jim Irsay wishes he owned more than one Super Bowl ring,...Read More
What exactly did Weiss do to keep his job with the Rockies?Oct 15, 2013
If you want to keep your job, get hired by the Colorado Rockies. Walt...Read More
Expect Navy-Air Force game to be close. Here's whyOct 4, 2013
Navy is a 14-point favorite to defeat Air Force in Saturday's...Read More
Does Air Force's football team stand a chance in Saturday's clash with Navy?Oct 4, 2013
What kind of chance does Air Force have to grab a victory in...Read More
Karson Roberts faces a big test ... if Air Force plays Navy on SaturdayOct 2, 2013
Karson Roberts delivered a superlative debut as Air Force's...Read More
There's hope - really, there is - for Air Force's embattled football teamSep 27, 2013
Air Force's football team is taking the concept of struggling...Read More
There's hope for Air Force's football team. I'm seriousSep 26, 2013
Air Force's football team is taking the concept of struggling...Read More
Imagine a college football world where a coach leaves LSU for ArmySep 26, 2013
Paul Dietzel, American hero and football vagabond, died this week, a day...Read More
Ramos, the 80-year-old busted for doping, says ESPN will soon tell his storySep 24, 2013
Don Ramos, a long-time Colorado Springs resident, is the oldest athlete...Read More
Air Force's Calhoun voices confidence in Charlton Warren, his embattled defensive coordinatorSep 24, 2013
This has been a brutal month for Air Force defensive coordinator...Read More
Talk about weird: An experience with Oakland Raiders message boardSep 23, 2013
Seven or eight years ago, I visited the official Oakland Raiders message...Read More
Broncos Knowshon emerges as whole new No. 27Sep 20, 2013
When friends and family and enemies and strangers mentioned Knowshon...Read More
Broncos can make big statement against Giants in New JerseySep 14, 2013
No Von Miller. No Champ Bailey. If the Broncos can topple the New York...Read More
Blogger Bio
David Ramsey has written sports columns for The Gazette for 10 years. He's visited all 50 states, and he's wise enough to realize Colorado is the best of those 50.
He's a graduate of Denver South High School, Abilene Christian University and Syracuse University, where he earned a master's degree in American History in 2003. He's placed nine times in the national Asssociated Press Sports Editors (APSE) contest, including two first-place finishes. He's covered the Athens, Beijing and London Olympics for The Gazette. He's the father of Ruth, a Rampart High grad, and Luke and Caleb, both grads of Pikes Peak Christian. He's an avid cyclist. He hopes to climb Mount Massive this summer, but he says that every year.
Gazette sports columnist David Ramsey brings you the personal side of sports along with his personal analysis.
Twitter: @davidramz


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Moderators: Jenise, David M. Bueker, Robin Garr
Jenise wrote:Bob Ross wrote:I like the tomato paste in a tube -- just like toothpaste.
Food should not come in squeeze tubes. Personal hygiene products come in squeeze tubes. Tomato paste is a food, not a pesonal hygiene product. Therefore, it should come in a can. [she said, making fun of one of her pet phobias]
Can't put my finger on it, but it creeps me out.
I am just revolted by tubes. You can guess, of course, that I use anchovies in cans only. And mustard out of jars. No squeeze bottles--too close to a tube.
Mustard out of squeeze bottles seems to me to be automatically of lesser quality, as if they put their old dregs or machine disfunctional batches in there.
Jenise wrote: It even annoys me to touch a tube of toothpaste when it's not full.
Bill Spohn wrote:I assume that your aversion to food in tubes was why you washed out of the astronaut program.....
Bill Spohn wrote:I'll tell them you are the toothpaste lady....
tube, or not tube, that is the question!
Jenise wrote:Yes, that was one reason. Didn't like the wardrobe much, either.
Users browsing this forum: No registered users and 4 guests


text:
Rated 4.6 out of 5Â by 25 reviewers.
Men's adidas Basketball Accessories
Padded Elbow Graphic Sleeve
Black/Lead (O25464)
Size Chart
+ Save To Wishlist
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Rated 4 out of 5Â by Iddy Padded Elbow Sleeve Review My sleeve is great and almost perfect. The only reason why it's not perfect is because I order mines too big. January 27, 2013
Rated 5 out of 5Â by MALEC Compression with protection I use this alternately with the PowerWeb Techfit sleeve. The pad protects my swollen elbow and the sleeve overall provides the compression I need to keep playing. I've ordered a couple more of this sleeve for the future, that's how much I like using it. Print has not faded after multiple washes, no sagging, still fits great after 3 months of use 3-4 times a week. May 18, 2014
Rated 2 out of 5Â by Adidas Official Reviewer 1 problem After using the shooter sleeve in action everything felt fine except for 1 thing the top of the shooter sleeve kept Slipping of and start sagging of with all other shooter sleeves in large size my arm fit perfectly but not with this one. December 27, 2013
Rated 4 out of 5Â by OregonDucks21 Good Sleeve but need tighter fit Overall, it is a very good arm sleeve, the only thing i didn't like was,I ordered a medium and it is still a little big. Just around the wrist area, everything else about the sleeve is perfect. January 15, 2014
Rated 3 out of 5Â by Scottie C. Padded, but decent fitment I like the padded elbow for extra protection, however the fitment/compression is not as good as the power web elbow sleeves. However still a very well made and stylish accessory. January 25, 2013


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With the wedding of Prince William and Catherine Middleton fast approaching, royal wedding swag is all over London! From newspapers to books and flags to condoms, their faces are plastered everywhere. Here's a sampling of what's to be found. -- Lisa Spodak
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Interchange News
Perl::Dancer Conference 2014
Posted on 22-Aug-2014 by Jon Jensen
Building on the success of last year's Ecommerce Innovations conference, another conference is being held this year from October 6-9 at West Branch Resort in Hancock, New York. The focus has been broa...
Read more...
Interchange 5.8.2 stable release
Posted on 07-Jul-2014 by David Christensen
We're pleased to announce the immediate release of Interchange 5.8.2, the latest stable version of Interchange. It includes all known bug and security fixes, as well as feature enhancements including ...
Read more...
About Interchange
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What Interchange users are saying:
"2 years ago we needed an e-commerce application which could provide us a multi-lingual solution and flexibility to extend the site in the future with connections to our backoffice. Interchange showed to be the best for the job, and it has helped us become the leading resource for diecast models in Greece, while maintaining a competitive position worldwide."
Manos Papanikos, CEO at allcarmodels.com.
Manos Papanikos, CEO at allcarmodels.com.
Users & Developers
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