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Targeted Drugs Delay Growth of Kidney Cancer
The targeted drugs sunitinib (Sutent) and sorafenib (Nexavar) can delay the progression of kidney cancer by 3 to 6 months over existing treatments, according to the results of final-stage clinical trials in the January 11 New England Journal of Medicine (NEJM).
The results also show how a "rational" approach to developing cancer drugs can succeed over the long term. Sunitinib and sorafenib, the first new therapies for kidney cancer since the 1980s, inhibit the growth of new blood vessels (angiogenesis) that feed tumors. Read more
Reflecting on Progress
This week we celebrate the life and legacy of Dr. Martin Luther King, Jr. Although he is often remembered for his work in the area of social justice, he understood very clearly the significance of health equality. "Of all forms of inequity, injustice in health is the most inhumane," Dr. King once stated.
This Thursday, I will have the honor of introducing Dr. LaSalle D. Leffall, Jr., as the keynote speaker at the NIH Commemorative Martin Luther King, Jr., Program. A noted cancer surgeon and the current chair of the President's Cancer Panel, Dr. Leffall has long been a leading voice on health disparities. He has lived the dream that Dr. King envisioned, making immense contributions to society based on the content of his character, not the color of his skin. Read more
Targeted Drugs Delay Growth of Kidney Cancer
The targeted drugs sunitinib (Sutent) and sorafenib (Nexavar) can delay the progression of kidney cancer by 3 to 6 months over existing treatments, according to the results of final-stage clinical trials in the January 11 New England Journal of Medicine (NEJM).
The results also show how a "rational" approach to developing cancer drugs can succeed over the long term. Sunitinib and sorafenib, the first new therapies for kidney cancer since the 1980s, inhibit the growth of new blood vessels (angiogenesis) that feed tumors.
Research at NCI and elsewhere in the 1990s showed that the majority of clear-cell renal cell carcinomas, the most common type of kidney cancer, have mutations in the tumor-suppressor gene VHL. These mutations can lead to the proliferation of blood vessels.
The first antiangiogenic drug tested was bevacizumab (Avastin), which blocks angiogenesis by inhibiting the vascular endothelial growth factor (VEGF). After a small study demonstrated that the concept was correct, sunitinib and sorafenib were tried.
"These trials represent a continuation of the initial approach with Avastin and a validation of the whole concept," says Dr. Ronald Bukowski of the Cleveland Clinic, who co-authored the sorafenib study.
Both sunitinib and sorafenib inhibit the receptors of several angiogenic factors, including the VEGF receptor 2. The drugs are oral medications that patients can take at home.
"The positive results from the two trials together confirm that we're on the right path to targeted therapy for kidney cancer," says Dr. Robert J. Motzer of Memorial Sloan-Kettering Cancer Center, who led the sunitinib trial.
"The sunitinib trial has changed the standard of care, and it's the first change in 20 years," says Dr. Motzer. He presented the data last June at the American Society of Clinical Oncology's annual meeting.
The trial compared sunitinib and interferon as a first-line therapy for the clear-cell type. In the sunitinib group, tumors took 11 months to grow compared with 5 months in the interferon group.
Sorafenib was compared to placebo in patients with the clear-cell type who had failed a previous therapy. The drug doubled the time to progression (5.5 months compared with 2.8 months).
While these drugs are likely to help patients live longer, it will be important to establish whether life expectancy might be affected by drug toxicities, says Dr. James Brugarolas of the University of Texas Southwestern Medical Center, who wrote an accompanying editorial in NEJM.
Both drugs are associated with side effects such as diarrhea, skin rash, and high blood pressure. In some patients the toxicities are severe.
The two trials demonstrate the benefits of rational drug design, notes Dr. Brugarolas. A better understanding of the biology of kidney cancer led to the hypothesis that inhibiting angiogenesis might affect tumor growth, and this turned out to be true.
"As a result we have three new drugs, and that is a remarkable success story," says Dr. Brugarolas, noting that a third drug, temsirolimus, is likely to win FDA approval.
The next challenge will be to learn whether patients might benefit from combinations of these drugs or from taking them in certain sequences.
"These drugs are a major advance for the disease," says Dr. Bukowski. "It is now up to us to learn how best to use them."
By Edward R. Winstead
Reflecting on Progress
This week we celebrate the life and legacy of Dr. Martin Luther King, Jr. Although he is often remembered for his work in the area of social justice, he understood very clearly the significance of health equality. "Of all forms of inequity, injustice in health is the most inhumane," Dr. King once stated.
This Thursday, I will have the honor of introducing Dr. LaSalle D. Leffall, Jr., as the keynote speaker at the NIH Commemorative Martin Luther King, Jr., Program. A noted cancer surgeon and the current chair of the President's Cancer Panel, Dr. Leffall has long been a leading voice on health disparities. He has lived the dream that Dr. King envisioned, making immense contributions to society based on the content of his character, not the color of his skin.
The celebration of Dr. King's legacy, however, is a stark reminder that many of the challenges that existed 3 and 4 decades ago still persist. While disparities in care now are well documented and recognized, we have lagged in our ability to bridge the disparity gap. And while NCI and others in the cancer community are working to change that, the fact is that too many minority and low-income people in the United States still do not have access to or don't receive the care they need and deserve.
To address this access issue, we recently initiated the NCI Community Cancer Centers Program (NCCCP) to study prevention, screening and treatment, and patient education. NCCCP will bring state-of-the-art, multispecialty care and early phase clinical trials to the community setting. Currently, about 85 percent of cancer patients receive care in the community where they live.
My participation in the commemorative program is only part of what we are doing to commemorate Dr. King's life and enact positive change. NCI's Center to Reduce Cancer Health Disparities (CRCHD) is reaching out to minority communities affected by cancer through a coordinated radio campaign designed to introduce more members of special populations to the Center and its work.
Through interviews largely on radio networks that serve Spanish-speaking and African American audiences, CRCHD representatives will discuss the Center's mission and provide listeners with information about cancer prevention, screening, treatment, and disparities-related research.
The campaign began on January 11, with Dr. H. Nelson Aguila of NCI's Comprehensive Minority Biomedical Branch conducting interviews on three major Spanish-speaking radio networks that reach U.S. and Latin American audiences.
Later this week, Acting CRCHD Director Dr. Sanya Springfield, along with other CRCHD staff, will conduct similar interviews with national minority radio networks. Also, today, Dr. Yvonne Vargas from NCI's Division of Cancer Prevention is appearing live on the nationally broadcast Dialogo: Costa a Costa (Dialogue: Coast to Coast) to discuss cervical cancer and Latinas, in conjunction with Cervical Cancer Awareness Month. These interviews will be catalogued soon at http://www.radiospace.com/NewsDirect.html#Health and http://www.radioespacio.net/salud.htm.
While there is much to be done to address cancer care disparities, outreach and education will continue to be an integral component of NCI's efforts. At a time when Dr. King is being celebrated for championing the voices of the unheard, we are proud to be reaching out to those who may benefit from our work the most but may know us the least.
Dr. John E. Niederhuber
Obesity and Weight Gain Linked to Prostate Cancer Mortality
The impact of excess weight on prostate cancer has been studied extensively without consistent findings. Now, a prospective study in the February 15 Cancer shows clearly that obese men are more likely to die from prostate cancer than men of normal weight, though no more likely to actually develop the disease.
Dr. Margaret E. Wright from NCI's Division of Cancer Epidemiology and Genetics (DCEG) and colleagues said their finding confirms earlier reports of an obesity-prostate cancer mortality link, but is the first to show that weight gain after age 18 also increases the risk of dying from prostate cancer.
"This is a large study that shows a convincing dose-response association between obesity and adult weight gain and death from prostate cancer," said Dr. Wright. Nearly 287,000 male AARP members aged 50 to 71 years self-reported their height and weight at enrollment into the NIH-AARP Diet and Health Study, begun in 1995. During the next 5 to 6 years, 9,986 developed prostate cancer and 173 died of the disease.
Compared with men with a body-mass index (BMI) of less than 25 kg/m2, those who were overweight (BMI 25-29.9) had a 25 percent increased risk of death, mildly obese men (BMI 30-34.9) had a 46 percent higher risk, and severely obese men (BMI greater than 35) doubled their risk.
"The growing prevalence of obesity in Western countries is alarming, and reducing the risk of prostate cancer death is only one among many health reasons to maintain a healthy weight through diet and exercise," said Dr. Wright.
Molecular Switch Controls Cancer-Implicated "Chaperone"
NCI researchers have discovered a molecular modification at a specific site on a protein implicated in tumor development that directly affects its activity. The protein, heat shock protein 90 (Hsp90), is called a "chaperone" because it aids other proteins - its so-called clients - in performing essential functions, such as helping them fold properly and escorting them to their proper place in a cell.
Published in the January 12 Molecular Cell, the study demonstrated that the addition of an acetyl group to Hsp90 at a specific site affects its ability to perform its chaperoning activity. When this acetylation was interfered with in both human cell and yeast cultures, Hsp90's ability to bind to its client proteins was strengthened; conversely, when the acetyl group was added to the site, its chaperoning activity was weakened.
Cancer cells use Hsp90 to, among other things, sustain cancer-causing mutations in certain client proteins, allowing the cells to escape growth regulation and develop into tumors. The study leader, Dr. Len Neckers from NCI's Center for Cancer Research (CCR), has been leading the effort to develop and test Hsp90 inhibitors in cancer treatment clinical trials.
In this current study, Dr. Neckers and colleagues also showed that when cells were treated with another class of anticancer drugs under development, inhibitors of the enzyme histone deacetylase (HDAC), which removes acetyl groups from a wide range of proteins, Hsp90 was acetylated and chaperone activity was inhibited.
"These results give us a better understanding of why promoting Hsp90 acetylation, by inhibiting deacetylation, might be a good approach to inhibiting cancer cell growth," said Dr. Neckers. "Now we can start thinking about combining HDAC inhibitors with Hsp90 chemical inhibitors for the treatment of cancer."
New Nanoparticles Form Promising Clots in Tumors
An interdisciplinary team of researchers has developed a nanoparticle system that mimics the clotting action of platelets by sticking to tumor vasculature and connective tissue and then recruiting more clotting elements and nanoparticles to that site. Study results were published online January 8 in the Proceedings of the National Academy of Sciences.
The team targeted its nanoparticles using a short peptide (cys-arg-glu-lys-ala, or CREKA) that binds to clotted plasma proteins in tumor blood vessels and stroma. They attached a fluorescent dye to one end of the CREKA peptide for imaging, and then coupled the peptides to 50 nm superparamagnetic, amino dextran-coated iron oxide particles (SPIO), which have been used as contrast agents for magnetic resonance imaging.
SPIO enhanced the fluorescence of the CREKA peptide conjugates, allowing clear imaging of the plasma protein meshwork in vivo in mouse tumors. By injecting decoy particles that slowed the clearance of CREKA-SPIO, the researchers were able to amplify the intensity and duration of the clotting, and hence the imaging effect.
"Some nanomaterials are capable of triggering system thrombosis," the authors wrote, "but here the thrombosis induced by the CREKA particles was confined to tumor vessels." They noted that the mechanism by which CREKA-SPIO induced clotting requires further study, and that other nanoparticles could be coupled with CREKA for similar imaging effects or other purposes. This indicates that the CREKA nanoparticle system has potential not only for imaging, but also for starving tumors of their blood supply by blocking vessels through local embolism or for slowly releasing drug payloads while blocking blood vessels in tumors.
The team, led by Dr. Erkki Ruoslahti of the Burnham Institute, initiated the research under NCI's Unconventional Innovations Program. They will continue their efforts with support from the NCI Alliance for Nanotechnology in Cancer program.
Availability of Radiation Services May Influence Use
Whether a hospital has onsite radiation services may influence its use in the treatment of pancreatic cancer, according to a new study. Patients undergoing surgery to treat pancreatic cancer at facilities with onsite radiation services were almost twice as likely to receive adjuvant radiotherapy, for which a benefit has not been established, as those treated at a facility without such services (42.9 percent vs. 26.1 percent), the study revealed.
In contrast, whether a hospital had onsite radiation services had no influence on its use for patients being treated for rectal cancer, for which adjuvant radiation therapy is often recommended. The rates of adjuvant radiotherapy were nearly identical in patients being treated for rectal cancer at hospitals with and without onsite radiation services (29.4 percent vs. 29.1 percent). The study was released early online January 8 by the journal Cancer.
"Our findings suggest that adjuvant radiotherapy for pancreatic cancer is either being over-utilized at hospitals with radiation facilities, or under-utilized at centers without them," wrote lead author Dr. Sandra L. Wong, from the University of Michigan Department of Surgery, and colleagues.
The researchers used NCI's SEER-Medicare registry to review records from 10,198 patients who underwent major resection for rectal or pancreatic cancer between 1992 and 1999. Radiation service availability was culled from the American Hospital Association's 2000 survey of U.S. hospitals. The researchers noted a limitation in their ability to definitively confirm the presence or absence of radiation services at 27 percent of the treating hospitals. These hospitals were excluded from the analysis.
Emissions from Household Coal Combustion Cause Cancer
An International Agency for Research on Cancer (IARC) monograph working group has concluded that indoor emissions from household combustion of coal are carcinogenic in the Group 1 category to humans, and are associated primarily with an increased risk of lung cancer. Dr. Qing Lan of NCI's DCEG was a member of the working group and her research in this area, conducted in Xuan Wei county in China, served as the primary evidence of carcinogenesis.
The working group also concluded that indoor emissions from household combustion of biomass fuel (mostly wood) and from high-temperature frying are probably carcinogenic (Group 2A category) to humans. DCEG scientists contributed to the research leading to these conclusions.
Exposure to environmental carcinogens varies widely around the world, but the use of solid fuels for cooking and heating is most common in low- and medium-resource countries, where about half of the world's population lives. "This provides a warning that exposure to indoor combustion products of coal and other biomass is hazardous, and that steps need to be taken to reduce exposure, such as improving indoor ventilation," said Dr. Lan, who pointed out that many millions of people are at increased risk from such indoor air pollution around the world. In fact, a study by Dr. Lan showed that improved venting of indoor combustion products resulted in a drop in lung cancer rates.
The working group was convened by the IARC Monographs Programme, the cancer research agency of the World Health Organization. A summary of the IARC evaluation was published in the December 2006 issue of The Lancet Oncology.
Robotic Prostate Surgery: Too Much Too Fast?
In the console - the command center of a robotic surgery unit - the surgeons have a super-magnified, three-dimensional image of the patient's interior. The camera providing those images perches on the end of one of four long robotic arms inserted into the lower abdomen via small "keyhole" incisions only a few centimeters wide. The other three arms hold the tiny instruments the surgeons use to perform what is, in effect, laparoscopic surgery.
According to Intuitive Surgical, which manufactures the da Vinci, the only surgical robot cleared by the Food and Drug Administration (FDA), 390 facilities in North America now have a robotic surgical device. The FDA only cleared the device for radical prostatectomy in 2001, yet, according to Intuitive, it is now used in more than one in every three such procedures performed in the United States. In some facilities, the device is used far more often.
"We have decided that 90 percent of what we do with open surgery we can do better with the robot," says Dr. Mani Menon, director of the Henry Ford Health System's Vattikuti Urology Institute, and one of the earliest adopters of robotic prostatectomy.
The expanding popularity of robotic prostatectomy - as well as robotic gastric bypass, mitral valve repair, and hysterectomy to treat cervical and endometrial cancer, among other procedures - has been fueled largely by patient demand, says Dr. David Lee, a urologic surgeon at the University of Pennsylvania Medical Center, which has five robots.
Because it's minimally invasive and, so far, appears to offer "the same level of outcomes for important parameters," he says, "I think it's appealing for everybody."
Even with such rapid proliferation, some urologists and urologic surgeons note that a true benefit of robotic prostatectomy compared with open surgery has yet to be shown. That's a significant piece of missing data, they argue, particularly in the face of the da Vinci's cost: approximately $1.5 million, which includes annual maintenance fees and disposable equipment costs (but excludes the time and resources needed to train surgeons on its use). That combination, they say, suggests that it could be premature to widely embrace robotic surgery as the standard of care for radical prostatectomy.
Waiting on the Data
"You can really do a precise dissection around the prostate because of the built-in advantages the robot has," Dr. Lee says.
The benefits of robotic radical prostatectomy, explains Dr. Peter Pinto, a surgeon in NCI's Urologic Oncology Branch in the Center for Cancer Research (CCR), appear to be less postoperative pain, less blood loss, and faster return to regular activities and work.
And based on short-term results from published surgical "series," he continues, robotic radical prostatectomy may yield equivalent cancer control outcomes compared with open surgery. Generally speaking, that means the removal of the prostate without leaving any cancerous cells at the surgical "margin." However, because of the short time that surgical robots have been in use, reliable data on biochemical recurrence - life without the return of prostate cancer - another important oncologic measure, aren't available.
So-called functional outcomes, mainly return to continence without the need for protection from urinary leakage and the ability to gain an erection and have sexual intercourse, also appear to be equivalent in robotic procedures compared with open surgery, Dr. Pinto adds.
Because of his advanced training in minimally invasive surgery, Dr. Pinto tells his prostatectomy patients that, in his hands, they are likely to have the best outcome with a robotic procedure. Even so, he cautions, overall, "there are not enough long-term data to support that this approach is superior to open surgery. It's still too new to say that."
Drs. Lee and Menon believe the oncologic and urinary function outcomes data - much of which are still unpublished - are trending in favor of the surgical robot.
For sexual function, says Dr. Lee, "That may be an area where we do a little bit better with the robot."
Dr. Menon says he is still pulling together data on a large series of patients - more than 1,600 with 5 years of follow-up - that is looking especially promising in terms of biochemical recurrence rates.
"Normally, it would take 10 years to accumulate so many patients," he says. "But robotics has been so well accepted by patients that we've been able to get the series."
In terms of oncologic outcomes, comparing the robotic procedure with open surgery is complicated by the slow-developing nature of prostate cancer, which can take up to two decades to develop into full-blown disease. So the ultimate measure, survival rates, will not be available for some time.
Even then, says Dr. Yair Lotan, a urologist the University of Texas Southwestern Medical Center, there may not be much to see.
"The bottom line is that it's difficult to improve on what Patrick Walsh did," he says, referring to the Johns Hopkins researcher famous for pioneering the "nerve-sparing" radical prostatectomy, an open surgery approach that offers good oncologic outcomes while also limiting damage to the nerves that ride along the prostate and control urinary and erectile function. "A survival benefit will be difficult to demonstrate."
Dr. Lee argues, however, that robotic surgeons only need to demonstrate that the less-invasive robotic procedure generates equivalent, not superior, outcomes to justify its use.
Even if the robot does turn out to have equivalent or superior outcomes compared to open surgery, Dr. Pinto is concerned about two things: the burgeoning popularity of robotic surgery, particularly among younger surgeons, and the reliance on a computer system running the robot that can "crash" during a procedure, which has happened once to Dr. Pinto. In that case, he subsequently completed the surgery by hand, with laparoscopic techniques.
"Today, surgeons still learn the open approach during training. However, if the current trend toward robotic surgery continues, there may come a time when young surgeons never see an open case," he says. "Although a rare occurrence, what happens when the robot stops working during the surgery? Will they have the skill set to complete the procedure safely?
By Carmen Phillips
Treating Colorectal Cancer Liver Metastases
Name of the Trial
Principal Investigator
Why This Trial Is Important
In this trial, colorectal cancer patients with six or fewer hepatic metastases will undergo primary surgery and/or ablation and then be treated with oxaliplatin and capecitabine. Half of the patients will receive additional chemotherapy consisting of floxuridine pumped directly into their livers through an arterial catheter and pump. This treatment, known as hepatic arterial infusion, delivers a very high concentration of chemotherapy directly to the site of the tumors. Because floxuridine is readily metabolized by the liver, side effects in other parts of the body are rare.
"The addition of hepatic infusion chemotherapy to standard systemic chemotherapy has helped prolong the lives of patients with liver metastases that could not be removed," said Dr. Wagman. "With this trial, we want to extend this treatment to patients with tumors that can be removed and see if it will help those patients live longer without recurrence of their cancer, and possibly result in a cure for some of them."
Who Can Join This Trial
Study Sites and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
NCI Remembers Christopher Michejda
Dr. Michejda was a professor of chemistry at the University of Nebraska in Lincoln before coming to NCI-Frederick in 1978. He received his Ph.D. in physical-organic chemistry at the University of Rochester and then went on to a postdoctoral fellowship at Harvard University. At CCR, his initial focus on chemical carcinogenesis evolved into drug development; he used his talent in chemistry to find new drugs against cancer and viral diseases.
"Chris was a valuable collaborator who provided unselfish and thoughtful leadership for numerous intramural initiatives, including the Director's Innovation Award review panel, the Chemistry and Structural Biology Faculty, and several other faculties and committees," said Dr. Bob Wiltrout, CCR director. "Our thoughts and prayers are with his family, friends, and colleagues."
DCLG Applications Now Being Accepted
Application instructions can be found at http://deainfo.nci.nih.gov/advisory/dclg/applications/2007DCLGapplication.pdf. Information about DCLG is available at http://dclg.cancer.gov/. Applications must be postmarked by March 30. DCLG members can serve up to 4 years and terms of office will begin in July.
Cancer Survivorship Publications Available
The Institute of Medicine recently published proceedings from a workshop held in May 2006: Implementing Cancer Survivorship Care Planning: Workshop Summary. Information about the report is available at http://www.iom.edu/CMS/26765/39416.aspx.
New Cancer Information Pages Added to Web Site
Following are newly released NCI research funding opportunities:
Understanding and Treating Ataxia-Telangiectasia
This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3646. Inquiries: Dr. Richard Pelroy - firstname.lastname@example.com
Understanding and Treating Ataxia-Telangiectasia
This funding opportunity will use the R21 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3647. Inquiries: Dr. Richard Pelroy - firstname.lastname@example.com
Understanding and Treating Ataxia-Telangiectasia
This funding opportunity will use the R03 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3648. Inquiries: Dr. Richard Pelroy - email@example.com
Research on Ethical Issues in Human Subjects Research
This is a renewal of PA-06-369 and will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3649. Inquiries: Kim Witherspoon - email@example.com
The Secretory Pattern of Senescent Cells
This is a renewal of PA-05-155 and will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3650. Inquiries: Dr. Suresh Mohla - firstname.lastname@example.com
Mechanisms, Models, Measurement, and Management in Pain Research
This is a renewal of PA-06-544 and will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3651. Inquiries: Dr. Ann O'Mara - email@example.com
Community Participation in Research
This is a renewal of PAR-05-026 and will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3652. Inquiries: Dr. Sabra Woolley - firstname.lastname@example.com
Innovative Technologies for Molecular Analysis of Cancer
This is a renewal of RFA-CA-07-007 and will use the R41/R42 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3653. Inquiries: Dr. Henry Rodriguez - email@example.com
Application of Emerging Technology For Cancer Research
This is a renewal of RFA-CA-07-008 and will use the R43/R44 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3654. Inquiries: Dr. Henry Rodriguez - email@example.com
Application of Emerging Technology For Cancer Research
This is a renewal of RFA-CA-07-009 and will use the R41/R42 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3655. Inquiries: Dr. Henry Rodriguez - email@example.com
Innovations In Cancer Sample Preparation
This is a renewal of RFA-CA-07-010 and will use the R43/R44 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3656. Inquiries: Dr. Henry Rodriguez - firstname.lastname@example.com
Innovations In Cancer Sample Preparation
This is a renewal of RFA-CA-07-011 and will use the R41/R42 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3657. Inquiries: Dr. Henry Rodriguez - firstname.lastname@example.com
Preserving NCI's Authority to Lead the National Cancer Program
The external advisory boards of NCI, including the Board of Scientific Advisors (BSA) which I am privileged to chair, met jointly last week to address the many critical issues now facing the cancer community. One concern widely felt by all of NCI's advisory committees is the need to preserve NCI's flexibility to manage the National Cancer Program during the current era of growing fiscal constraints on the entire biomedical research budget. Many unique programs and research initiatives have been created by NCI as a result of the special authorities and mission it was given by the National Cancer Act of 1971, which were so well described in the recent special issue of the NCI Cancer Bulletin.
The members of NCI's advisory boards believe strongly that NCI's senior leadership must retain the Institute's full responsibility and accountability along with its ability to redeploy resources and revise programs as they deem appropriate. Only a small portion (approximately 5 percent) of NCI's annual budget can be considered flexible and available to the Director to support or redeploy resources into novel areas of high-priority science. In this era of shrinking budgets, this 5 percent provides the principal support for this flexibility and creativity.
The boards' members recognized that the NIH Reauthorization Act is an important step in improving the efficiency and coordination of the federal government's overall agenda for biomedical research. It is important to recognize that this new legislation reaffirms the special authorities previously granted to NCI.
The NCI advisory boards stressed the urgent need to protect the limited funds available for NCI's discretionary deployment and believe that NCI's ability to respond to its mandated mission should not be compromised.
NCI's advisory boards' members believe that NCI's accountability to the American public and the cancer community to alleviate the burden of cancer requires that the Institute retain its full authority to act in accordance with that vital mission. We reiterated our full confidence in the NCI Director and Executive Committee to make the necessary and best decisions to redeploy fiscal resources and revise programmatic goals and policies in light of budgetary constraints. This is particularly true of NCI's unique research programs that differ from the traditional individual investigators awards.
The boards also expressed concern about the challenges of NCI absorbing substantial increases in the yearly contributions to support the NIH Roadmap Common Fund during a period of current and future budgetary challenges.
The new NIH Reauthorization Act establishes new structures for accelerating the pace of biomedical research in the country and more clearly defines NIH's leadership in that process. The NCI advisory boards are fully committed to working productively to facilitate this process. However, we are determined that the changes not inadvertently endanger the mission of NCI.
Dr. Robert C. Young


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A body was found in a Riverview landfill. Investigators say the death of 29-year-old Derek Golden of Grosse Pointe Park appears suspicious, although they still don't know how he died."Mr. Golden's body was recovered amongst demolition debris from home demolition," said Riverview Police Deputy Chief Clifford Rosebohm.An excavator moving debris from one part of the landfill to another made the gruesome discovery.Police say the troubled young man with a history of drug-related arrests was last seen on December 9. The family car, a 2006 black Subaru Tribeca, was discovered at Warren and Conner in the DHS parking lot there on Detroit's east side. He had told his parole officer he was checking into the Salvation Army for substance abuse, then last week, more than three months after his family last saw him, his body was discovered."At this point in time, we're also looking into his phone records to kind of give us some more clues as to what happened from December 9th moving forward to the 26th of March," Rosebohm explained.Police say they have been receiving tips, but they need more information, and Crime Stoppers is now offering a generous reward. You can remain anonymous. If you have any information on the death of Derek Golden, contact Crime Stoppers at 1-800-SPEAK-UP."If the tip that leads to an arrest is received by midnight tonight, there is an additional $1,000 reward for a total reward of $3,500," said John Broad with Crime Stoppers. "We cannot bring a murdered family member home, but we can bring justice to a community and closure to the family."
WHBQ-TV | Fox 13 485 S. Highland St.Memphis, TN 38111Main Station: (901) 320-1313Newsroom: (901) 320-1340


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Start your day with a roundup of top defense news.
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text: It's great how early on in this video, Dikembe is saying how Jordan has never dunked on him. Well of course that was enough motivation to get him. Being a Bulls fan I really miss these days, it's not fun watching the Heat put a beat down on your favorite team.


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Threaded Thoughts by Judith Dierkes
Threaded Thoughts
by Judith Dierkes
Reception:Tue, Jun 25, 6:30-8pm
Threaded Thoughts of Judith Dierkes is an exhibit of works tied together by medium. Her work is best described as "quilted paintings" and fits in the current art movement called Studio Art Quilts. She has a BFA and MS from the University of Tennessee in Knoxville. Quilting of the canvas came after much experimenting with drawing, painting and screen printing. Both her grandmothers were traditional quliters and perhaps influenced her in that direction. Many art historians and critics consider all fiber work to be a feminist statement because the medium was traditionally "women's work". However, this is not your grandmother's quilt. Dierkes uses contemporary techniques like computer images printed on fabric, fabric markers, and screen printing on fabric to allude to traditional ways of piecing fabrics together.
Judith Dierkes is originally from Tennessee. She has a BFA and MS from the University of Tennessee in Knoxville. Her work is permanently installed in public places like the Knoxville Airport and Vanderbilt Children's Hospital in Nashville. Her work traveled in Edge to Edge: Selections from Studio Art Quilt Associates with the Museum of American Folk Art and Roots of Racism: Ignorance and Fear with the Art in Embassies. She has participated in many solo and juried shows throughout the United States. Judith is an artist in residence with the Tennessee Arts Commission, Nevada Arts Council, and the Arkansas Arts Council where her primary residency is making quilts with kids. She teaches online art appreciation classes for a few colleges in Tennessee. She is considering offering quilting classes in her Rockwood Studio in Salt Lake City this summer.
Location: Sprague Branch
Contact Information: (801) 594-8640


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Search Results for: omnichannel
August 11, 2013
Pure-Play vs. Omnichannel: Which do Consumers Prefer?
Amazon.com made waves in July when its stock price topped $300 a share for the first time – but the e-commerce giant is not the only game in town. Omnichannel retailers such as Walmart, Target, and Best Buy are taking aim …More...
August 7, 2013
Lids Makes Omnichannel Deal With Macy's
Macy's Inc. and LIDS Sports Group, a subsidiary of Genesco Inc., announced each have signed an agreement to open a licensed team merchandise department in Macy's stores and online, according to a press release.
Both companies plan to …More...
In News
August 1, 2013
Omnichannel Fulfillment Is Here To Stay
When it comes to various shipping options for the larger merchant, ship-from-store is not just a passing trend, according to Manish Chowdhary, founder and CEO of GoECart.
These larger merchants, because of the heavy footprint they have with physical stores …More...
July 31, 2013
Delivering the Omnichannel Promise This Holiday Season
What is the best way to reach and secure the anytime, anywhere consumer this holiday season? According to Branden Jenkins, general manager of etail and retail for NetSuite, the answer is omnichannel.
During a recent one-on-one interview with Multichannel Merchant, …More...
July 26, 2013
Merchants See Increased Satisfication with Omnichannel Fulfillment
Ecommerce has now become synonymous with omnichannel. While merchants are focusing their retail efforts on social, mobile and email, the real effort should be on a variety of fulfillment options, according to a new whitepaper by Innotrac.
A quick Google …More...
July 18, 2013
Why Omnichannel Fulfillment Matters
Shopping habits, shopping devices, and shopping locations are interchangeable in the customer's eyes, which is why it's more important than ever for merchants to offer a wide variety of omnichannel fulfillment options, according to Bill Toney, senior vice …More...
October 30, 2013
Big Data Brings Omnichannel to Life [LP]
Click the image below to download
"Big Data Brings Omnichannel to Life"
In Landing Page
October 30, 2013
Big Data Brings Omnichannel to Life
Big data has become quite the buzzword in all facets of omnichannel selling. It's being used in both the front- and back-end of operations, in the marketing department, and site design all in the name of boosting customer engagement …More...
September 28, 2013
Preparing Your Warehouse for Omnichannel Fulfillment
With U.S. ecommerce sales surpassing the $200 billion mark it is increasingly important that merchants develop a process to integrate sales channels and manage fulfillment efficiently and effectively. In this executive summary from Multichannel Merchant, you will learn how to …More...
November 18, 2013
Omnichannel Advantage Helps Retailers Gain on Etailers
A year ago, it seemed inevitable Amazon would take over the world. Industry watchers predicted retailers like Best Buy and Target, with their overhead of physical stores, would soon lose the ecommerce battle. After all, consumers increasingly visit big-box retailers …More...


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Raquel's Q & A
Favorite Sport/Team
Miami Heat...woop! woop!
Favorite Movie/Actor
Sam Jackson in anything
Go-to karaoke song
I'm sexy and I know it...I WORK OOOOUT!
My first job
Hostess with the mostest
Piercings/Tattoos (How many? Where?)
Four tattoos and if I tell you where I'll have to kill you
Mac or PC?
I love my apples baby!
Nintendo, Xbox 360, PS3, or don't game?
Does "words with friends" count?
What fun fact, talent or superpower of yours should guys know about?
I have x-ray vision and I can make it clap (wink wink, son!)
What's the most memorable pick up line you've ever heard?
A homeless man once asked me "Can you spare some change?" "No? Ok, Can you spare some pussy?"
What's the craziest thing you've ever done?
Cage dive with sharks...nude of course
What's the most unusual place you've ever hooked up? How'd it go?
The summit of Mt. Kilamanjaro, jk! The sauna in my ex boyfriend's building, totally hot a steamy
What's in your purse or pocket right now?
I think I'm supposed to say something sexy like lace panties and KY Jelly but I only have lace panties and KY Jelly in my pocket.
What do you feel most comfortable wearing?
A smile ;) and my assless chaps
Would you rather have boring sex all the time or an amazing romp once a year?
This is the hardest decision of my life....I'd say one mind-blowing, life-altering f*** annually but my only stipulation is that I get to record it for the other 364 boring days.
If you could do a shot of Jose Cuervo with anyone -- dead or alive -- who would it be?
I choose Charlie Sheen!


text:
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Prices and availability are subject to change from the time and date that you print this page.
10/2/2014 10:41:12 AM. For Customer Service, please call 800.933.9904
Use these mod metal numbers to write out everything from a kid's birthday to somebody's age to your bank routing number. Although, we don't really recommend that last one.
8 Magnificent Metal Number 12"H
- Nod exclusive
- Large metal numbers
- Inspired by vintage marquee lights
- Each number has a depth of 2.75" allowing a flat surface to double as a shelf
- Ampersand and Hashtag/Pound Metal Symbols also available
- Features hooks on back for easy hanging
- Hanging hardware not included
- Can be hung on the wall or set on any shelf or bookcase
Details, details
Show 'em what you're made of
Style options
Extras! Extras!
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Who's there?
Amos who?
A mosquito bit me!


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We want to ensure that making a return is as easy and hassle-free as possible! If for any reason you decide that your purchase just isn't for you, simply return the item within 30 days of receipt and we'll cover the return shipping when you choose our FREE Pre-Paid Return Shipping Label. Learn more about our return policy.
Shop now and get Free Value Shipping on most orders over $29.95 to contiguous 48 states, DC and to all U.S. Military APO/FPO/DPO addresses.
Unfortunately Earhugger Safety Inline Push To Talk 50inch Cord is no longer carried by OpticsPlanet.
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Inline Push To Talk 50" Cord 0010046
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[Skip to content]
This area is aimed at staff and trustees in our member hospices and aims to provide a range of resources, news and information.
We have updated our systems and some passwords need to be reset. If your password is not working, you can reset your password by email.
We apologise for the inconvenience.


text: Oh, and I think that Wizard of Oz is an American thing. Because I just do not get what's so great about it, never have. I've talked with friends, and it kind of seems like this is one of those things one needs to grow up with, in order to properly enjoy.


text:
VIRGINIA BEACH— Expected storms could put a damper on events at the Oceanfront Saturday night.
"It was hot, but it started to cool down a bit," tourist Lisa Bridegam said.
Nearly ten thousand people will come to enjoy the Monster Truck show at the Oceanfront. "One thing we did during our noon show is we adjusted our intermission to be right when it was raining. At that point, we were able to come right out and finish the show," Mike Hilton show organizer said.
Hilton explained they've been closely watching the radar to plan out their events. "Our policy is we try to go rain or shine. If there is dangerous weather, we will make adjustments and stop the show,"


text:
Table of Contents
Collection Overview
Collection Inventory+/-
Content Description
Collection Use
Administrative Information
Collection Overview +/-
Collection Inventory +/-
Box 1:
Fd 1 From Mrs. Joseph McDermott
Fd 2 To J.H. Olsen from J.F. Crouch
Fd 3 To Sarah Langsdon from James H. Olsen Jr.
Fd 4 To Y.F. Jones from D.W. Robertson
Allen-Warner Valley
Fd 5 Allen-Warner Valley Energy System Presentation
Alton Coal Project
Fd 6 Alton Coal Project –Mine Plan and Financial Analysis
Cedar City Operations
Fd 7 Cedar City Operations –Location Map
Fd 8 Cedar City Operations –Mining Sequence Ten Year Forecast, 1975
Fd 9 Cedar City Operations –Monthly Alluvium Report
Gas Hill District
Fd 10 Gas Hill District, Wyoming –Contributions to Geology
Gonyella, Australia
Fd 11 Goonyella, Australia –Long Term Planning Document
Iron Mountain
Fd 12 Iron Mountain –Alluvium Ore Value Calculation
Fd 13 Iron Mountain –Bucket Drilling
Fd 14 Iron Mountain –Geologic Sections
Iron Springs
Fd 15 Iron Springs
Fd 16 Iron Springs –Alluvium Mining and Field Processing Report
Fd 17 Iron Springs –Concentration of Low-grade Iron Ore with a Mobile Magnetic Plant
Fd 18 Iron Springs –Crushing and Stockpiling Facilities
Fd 19 Iron Springs –Crushing, Sizing and Blending Installation
Fd 20 Iron Springs –Development of Production Rates
Fd 21 Iron Springs –Direct Mining Costs
Fd 22 Iron Springs –Direct Plant Costs
Fd 23 Iron Springs –Indirect Costs
Fd 24 Iron Springs –McCahill-Thompson Alluvium Dry Land Dredge
Fd 25 Iron Springs –Mining Area
Fd 26 Iron Springs –Value of One Ton of Ore Mined
Fd 27 Iron Springs –"Welcome to Utah Construction and Mining Co. Iron Springs Operation"
Kaiparowits Project
Fd 28 Kaiparowits Project –Iron County Record Newspaper Letter to the Editor
Fd 29 Kaiparowits Project –Iron County Record Newspaper Letter to the Editor news clipping
Lucky Mc Mine
Fd 30 Lucky Mc Mine
Public Service Coal Co.
Fd 31 Public Service Coal Co. –Contract Mining Proposal
Box 2:
Navajo Mine
Fd 1 Navajo Mine 1960-1983 –CD of Photos
CD also contains: Correspondence to Sarah Langsdon, Associate Curator of Special Collections (Printed copy available in Correspondence), 2 deed of gifts, and an inventory by James H. Olsen Jr.
Fd 2 Navajo Mine News Paper –Navajo Nation Fair 1975 Edition
Pinto-Iron Springs Mining District
Fd 3 Pinto-Iron Springs Mining District Property Map
San Juan
Fd 4 San Juan Coal Sales Pricing –Revised Analyses June 10, 1975
Fd 5 "Cedar City's Mobile Concentrator" –Utah Report –Nov/Dec 1964
Fd 6 Dames & More Engineering Bulletin #41
Fd 7 First Aid for the Mineral and Allied Industries
Fd 8 HP-45 Surveying Routines
Fd 9 "How Utah Construction Recovers Iron Ore from Alluvial Deposits" –World Mining
Fd 10 "Iron Mining: A Southern Utah Industry"
Fd 11 "Iron Ore Mining in Utah" –January 15, 1959
Fd 12 The Mine Development Process
Fd 13 Mining Congress Journal: Concentrating Iron Ore –Oct 1965
Fd 14 Mining Engineering Magazine –SME Membership Directory July 1983
Fd 15 "Mobile Magnetic Iron Ore Concentrator"
Fd 16 Power Handbook: Basic Power Facts Made Easy
Fd 17 Tunnels & Tunnelling (sic)
Fd 18 Universal Producers Fact Book
Fd 19 Utah Directory –Nov 1975
Fd 20 Utah International 1976 Report
Fd 21 Utah Report –May/June 1975
Fd 22 Alluvium Plant Data
Fd 23 Bumper Sticker "Utah Mining for America"
Fd 24 Department of the Interior, Mining Enforcement and Safety Administration Certificate of Completion –First Aid
Fd 25 Engineering Data
Fd 26 Method Used to Estimate Ore Reserves
Fd 27 Minerals and their Characteristics
Fd 28 Page's Pages –Math and Engineering Data
Fd 29 Radio "10-Codes"
Fd 30 Traverse Procedure
Fd 31 Utah International Inc. Vacation or Leave Application
Fd 32 Wind Chill Factor
Content Description +/-
James Olsen Sr. and James Olsen Jr. worked as Engineers for the Utah Construction and Mining Company. The mines they worked in were primarily in the Western United States. James Olsen Jr. donated this collection to WSU in May 2009. The collection is arranged by subject headings alphabetically with a miscellaneous section placed at the end of the collection.
Collection Use +/-
Restrictions on Access:
Open to public research.
Administrative Information +/-
This collection is arrranged by subject group. This collection is unprocessed.
Acquisition Information:
donated by James Olsen, 2007
Processing Note:
This collection was processed by a Special Collections processor.
Olsen, James
Collection materials are in English.
Library Services and Technology Act (LSTA) grant, 2007-2008
2 boxes
Language of the Finding Aid:
Finding guide is in English in Latin script.
Author of the Finding Aid:
Finding aid created by Sarah Langsdon.
EAD Creation Date:
Finding aid based on DACS (Describing Archives: A Content Standard).
Subjects +/-
Corporate Names:
Utah Construction Company
Subject Terms:
Mines and mineral resources
Personal Names:
Olsen, James
Geographical Names:
Ogden, Utah


text:
This is a slight amendment to jimmyxx at gmail dot com function
I tried using the regex displayed in his code, and php threw up a couple of errors
Below is the correct regular expression that works
(Please note that I had to split the regex into strings because php.net was complaining about the line being to long)
"|<meta[^>]+name=\"([^\"]*)\"[^>]" . "+content=\"([^\"]*)\"[^>]+>|i",
$html, $out,PREG_PATTERN_ORDER);
The problem was due to the quotes being incorrectly escaped.
I hope this helps anyone who has been having problems with his code


text:
The Homi Adajania directed quirky comedy, 'Finding Fanny' is slated to release in September but the makers have released the trailer already, on July 8th. Within 2 days the trailer has received more than 1 million hit, clearly proving that the audience is interested in watching the film. I
Rola Pe Gaya - Remix [Full Song] Patiala House
dimple kapadia
When Bollywood celebs tie the knot, it becomes a much hyped event with fans and media persons following their every move. But what begins well does not end well always. Some Bollywood marriages that looked like a fairytale ended when harsh reality came crashing down. After the recent divorce betw
Producer Ekta Kapoor has organized a grand Iftar party on 6th August to celebrate the holy month of Ramadan and to mark the release of her forthcoming film, 'Once Upon A Time In Mumbai Dobara' on August 15th. When asked, she said, "It's true and I also keep roza (fast) some tim


text:
New England Patriots tight end Rob Gronkowski joins the crew of Whose Line Is It Anyway for a couple of hilarious skits.
First, Gronkowski jams out with Wayne Brady and Jonathan Mangum.
Then looks for some "protein."
I wonder what Patriots owner Robert Kraft has to say about this?
Thumbnail photo by Jack Newton [Public domain], via Wikimedia Commons


text:
DETROIT, MI (WTVB) - A decision on the eligibility of former Detroit Medical Center CEO Mike Duggan in his run for Mayor of Detroit may be issued today by the Michigan Court of Appeals. The court agreed Friday to give expedited consideration to Duggan's appeal of a lower court's ruling to remove his name from the ballot.
Rival candidate Tom Barrow is trying to knock Duggan out of the race saying Duggan violated the terms of the City Charter and was not a city resident for one year before the deadline to file election petitions. Barrow also has asked the Michigan Supreme Court to rule on the matter.


text:
Its just nice theory about future, cryptoalgorithms and politics.
[politics on]
Someone ask good question.
@anonymous at 7 June 2011 02:17
> why you release files now?
So, time to talk about politics and my try to effort a little support to "Navalny".
Please, start read carefully at first post.
And try draw you own conclusion.
Hint tags: dissident, security, politics, eavesdropping, belarus, egypt freedom.
I don't want to Russia FSB (Fima Sergeevich Bushmanov, haha) to stop process of Liberty. And to allow overtake it by Putin regime.
I don't want another one-political-party-for-all like 'KPSS' to be present here for ages. 'Edinaya Rossia' should take away from political scene for next years.
See http://navalny.livejournal.com/ blog for details. If there is no political competitions, there is no freedom. This is way to hell and Stalinism(Putinism).
I like two political parties at least, like in USA or EUROPE.
So, i want provide info about strong VOIP encryption way for all dissidents. Now, only skype software provide unbreakable strong level of voice encryption and widely used. Skype owned by MS, i bet, will not provide that, because of money and political engagement.
Only 'individual' vs 'big corporations' can do this.
My aim is to overtake political regime in Russia(Ha-ha!), if it will probably take in stagnation, because of Putin or Medvedev indirect corruption support.
Check http://russian-untouchables.com/ site. For get a alternative political view of Russia today.
In worst cases scenario, we can change skype RSA 'main' public and secret Certification Authority (learn PKI) key, and use our own secure network 'based on skype binary' for allow rebellion flashmobs. We just need change ip addresses of login server, and change CA public key certificate in binary.
Take a look on "Strategy 31" group in Russia.
Yes, they a morons, but they are try to make freedom for all of us.
Regional elections was already illegally(but they claims it was legal, of course) overtaken by current 'Edinaya Rossia' and Putin administration regim.
So, regional politics people will count, like "Pi == 10 in war times".
In 2011 December.
We should not admit or allow it.
Have the true securely private communication is one most important point to overtake regime. Egypt proof of it.
So, take very, *very* care about FSB trojans and viruses. But still use Skype for securely communication. Even, if someone claim that it insecure. It is secure. Until someone hack in your or your's peer computer. Or until someone break AES - American Encryption Standard(and until Skype CA trusted). And it will be even more secure, when we will have open-source Skype protocol specification.
Yes, i am talk like crazy-russian-bear.
But it was like i thinking.
[politics off]


text:
Narrow your search
The brand new Voicemail+ app, launching for the iPhone in the UK today and in the US later this year brings text transcription, e-mailed voicemail receipts, push notifications, and it matches your messages to your contacts.
Pricing not available
More than just a news app, Yahoo stands out for its customization and search tools.
Pricing not available
More than just a news app, Yahoo stands out for its customization and search tools.
Pricing not available
Mike Newman was born blind, but that hasn't stopped him pursuing his passion for speed. He recently became the first blind person to drive over 200mph -- XCAR finds out how he does it.
While it's great-looking, Stache is too much of a hassle to make it a good replacement for managing bookmarks in Safari.
Pricing not available
It's a shame early visual-effects pioneers aren't alive today to see what they started, but you can. Take three minutes out for one dizzying ride through the evolution of VFX.
What are the masses discussing on Facebook, Twitter, or other social networks today, this week, or this month? BuzzSumo provides a simple dashboard to keep you informed.
The tech giant buys another company, this time a startup that lets people create infographics and videos out of social data.
The Web giant continues to amp up its low-cost streaming media dongle with various small features.
Compilation shows the magic from every Academy Award for Best Visual Effects in film since 1977.


text:
California Licensed Drugstore. Our pharmacy is in business for over 25 years. Our website services our clients for more than 18 years.
Home | Day Dew | Disclaimer | Medication GuidesQ&A | Buying Drugs from Internet. | FDA Med Watch Program. | Notice to Consumers | Ryan Haight Act DisclosureHow to Dispose off Unused Medicines? | How to Dispose off used Insulin Needles? | Quit Smoking | VIPPS Program | Daily DealsWeekly Special | Monthly Specials


text:
After his awesome performance at the MTV VMA's we get even more Justin TImberlake! Oh yeah and Jay-Z! Here is the music video for Holy Grail!
Aww doesn't being alone in a HUGE mansion stink! Well actually those "ghost women" would make me move!
What do you think of the new video?


text: Funeral services will be held for Fannie Sue Dean Merritt, 76, at the Chapel of Rose-Neath Funeral Home in Homer on Tuesday, Dec. 11, 2012 at 11 a.m. with Rev. Bill Mills, officiating. Interment will follow at Tulip Cemetery. The family will receive friends at the funeral home on Monday from 5-8 p.m.Subscribe to Read!


text:
First Female Rap Artist to Go Platinum in Eight Years
Pink Friday remained at the top of the charts for several months after its release, and in January 2011, the project was officially certified platinum. Nicki became the first female rap artist to reach this milestone in eight years, when her rap rival Lil Kim's La Bella Mafia LP went platinum in 2003.
(Photo: Gregg DeGuire/PictureGroup)
On 106 Tonight: 'The Maze Runner' Cast09/19/2014
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Exclusive Access: Chris Brown & Jada Pinkett-Smith09/16/2014
Exclusive Access: August Alsina World Premieres of 'No Love'09/16/2014
The Buzz: French Montana Speaks Post Khloe K Breakup09/16/2014
Exclusive Access: U.D.L. Semi-Finals Yellow vs. Red09/15/2014
Jada Pinkett-Smiths Five Toughest TV/Film Roles09/15/2014
The Buzz: Soulja Boy Talks Fatherhood, Reality TV09/15/2014
Five Things We Liked About Chris Brown's X09/12/2014
The Buzz: Tahiry Speaks About Fashion Week Fight09/12/2014
The Buzz: Nicki Minaj and Beyoncé's Flawless Photo09/11/2014
Exclusive Access: Taraji P. Henson & Russell Westbrook09/10/2014
The Buzz: Ray Rice Speaks Out, Tahiry Gets Attacked During09/10/2014
The Buzz: Tyga Denies Kylie Jenner Rumors09/09/2014
Exclusive Access: U.D.L. Green vs. Gray09/08/2014
The Buzz: Momma Dee's Teeth Fall Out During Set09/08/2014
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text:
0 Members and 1 Guest are viewing this topic.
Everybody is Green....The Beatles - You Can Do That [HD]
I have always loved and been fascinated by the way John 's facial expressions and vocal timbre seem disjointed as he's singing. He's got this awesome raspiness to his voice when he's hitting the high notes and you'd think t these points in the song his face would look like he's really straining to achieve that effect. And yet when you see him in this video and elsewhere his face is completely relaxed, and there is no apparent effort exerted on his part as he achieves his "signature sound" --- efortlessly This is part of the magic of John Lennon.Thanks for the vid, bobby.John K
Roy was bad ass....as was Mr. Lennon
This was George's last public performance...how fittinghttp://youtu.be/6-l1y0gnSnI
How? And Why?I will ask those questions about these songs and these musicians until the day I die. The Bach(s) of modern music😀John K
I believe it ain't no secret here that Georgie is my fav of the fab
Mine too Bob...BTW, in case you haven't seen it, here is the full broadcast of the show on VH-1 that that clip was from:http://youtu.be/Fpf8TstFNEc
Sorry Slow Hand.....


text:
By Aly Semigran, Hollywood.com Staff
One of the biggest gripes many have against the cast of the Jersey Shore, much like the argument regarding most reality television stars, is that they are famous for no good reason. That they make buckets of money for often deplorable behavior and are causing the downfall of civilization. But even if you are of the variety that doesn't find the antics of The Situation amusing, not even the most hardened cynic or reality TV detractor could have a bad thing to say about the good deed that the cast of the Jersey Shore did on Thursday night.
Cast members Vinny Guadagnino, Nicole 'Snooki' Polizzi, Sammi 'Sweetheart' Giancola, Deena Cortese, Jenni 'JWOWW' Farley, Pauly D, and Ronnie Ortiz Magro (Mike 'The Situation' Sorrentino was MIA for the broadcast) all took part in Restore the Shore, a one-hour special devoted to raising money for the devastated Jersey coastline, which was ravaged late last month when Hurricane Sandy hit. To date, the storm has killed 110 people in the northeast region, and has left countless others with lost or damaged property. While the beach house that the Jersey Shore cast has called home for six seasons was not impacted by the hurricane, the gang still did their part to help those who were effected by Sandy.
Hosted by MTV personality Sway, the program which also featured musical performances from Phillip Phillips and Gym Class Heroes and special appearances by Pink, Christina Aguilera, Simon Cowell, Kelly Clarkson, Jay Leno, and Kim Kardashian, among others was as touching and important as the telecast that NBC Universal held two weeks ago to raise money and awareness.
The cast who looked understandably shocked, saddened, and humbled by the devastation they witnessed firsthand when they visited the region talked to Seaside Heights locals who lost everything, helped their boss Danny clean out his ruined business, and did whatever they could to help. ""I wanna do everything I can to help rebuild Seaside...it breaks my heart,"" an emotional Snooki, who also joked that if their unscathed house could survive them, it could take on that ""bitch Sandy,"" declared. Vinny shared that he was helping not only at the Jersey Shore, but the ravaged Staten Island, his home town.
While it's difficult to wrap one's mind around the chief of police rightly calling the Jersey Shore cast ""good kids"" for returning to the place that made them famous to lend a helping hand, that's nothing compared to the footage they're seeing or imaging the pain and loss those along the shore are suffering. Even the most fervent fans of Jersey Shore have cried that they are bored with the turn the cast and the show has taken lately, but if this is the new Jersey Shore, one that helps make a new Jersey Shore, this terribly bittersweet ending should make a fan out of all of us.
Watch some of the heartbreaking clips from Restore the Shore below, including a visit with Seaside Heights' mayor Bill Akers:
Get More: Restore The Shore, Full Episode
Get More: Restore The Shore, Full Episodes
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Did you pick up your duck phone and donate? Were you inspired to see the Jersey Shore doing their part to help the town that gave them so much? Are you a new fan or renewed fan of the show thanks to the Restore the Shore telethon? Share in the comments section below and don't forget, you can still donate to relief efforts here.
[Photo credit: MTV]
More: Jersey Shore House Miraculously Survives Hurricane SandyCelebrities Tweet Their Hurricane #Sandy SupportBruce Springsteen, Christina Aguilera, Jon Stewart, and More Shine On Hurricane Sandy Telethon


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Issue 3 of the @JOFL4D is now out. JL4D is a continuous publication journal.
UNESCO to host online Oxford Union Debate on mLearning | United Nations Educational, Scientific and Cultural Organization
Starting on 18 September, UNESCO will be holding a 9-day online Oxford Union debate on the topic of mobile learning (mLearning). Moderated by Barbara Reynolds (Guyana), the debate will feature Steve Vosloo (South Africa) as the Idealist and Osama Manzar (India) as the Realist. This Oxford Union debate will be held on the WSIS Community platform, allowing the public to actively participate and influence the outcome of the debate.
Welcome to a MOOC (Massive Open Online Course) on the use of Open Educational Resources in the classroom. This four week course is free and open to all registe…
Via Ramesh Sharma
"The handbook offers an introduction to various open education topics including open education data, open education resources, learning and teaching practice, open source tools and open accreditation. It is currently available in Booktype, an open source book authoring tool, and can be edited by anyone."
From icde
The LangOER project has released a report with the findings of its first study of Open Educational Resources (OER) in less used languages.It includes a separate
sofipapadi's curator insight, August 13, 3:09 AM
a report with the findings of its first study of Open Educational Resources (OER) in less used languages
From karisma
"The report commissioned by the UNESCO Regional Bureau for Science in Latin America and the Caribbean, "Public Spending in Latin America: Does It Fulfill the Declaration of Paris' Suggestions for Open Educational Resources?" is now available in English."
From vipsi
From www
The International Review of Research in Open and Distance Learning (www.irrodl.org) is a refereed e-journal that aims to advance research, theory and best practice in open and distance education research.
Alberto Cardoso's curator insight, July 10, 4:38 AM
" This issue features several pieces that highlight the business of successful teaching, faculty-learner and learner-learner interaction. From Serbia, Raspopovic, Jankulovic, Runic, and Lucic examine, in a case study, success factors in e-learning, from the perspective of a developing country in transition from traditional modes of learning to technology-enhanced modes of learning."
From oersys
"National OER policies determine the framework within which other OER actors can develop. By doing so they form a mighty leverage to shape the OER ecosystem of a country. Though we are still at the beginning, initial achievements are promising. Approaches like the OER policy registry by Creative Commons provide the possibilities to follow and speed up the development. Supportive will also be, that openness and sharing are among the core values of the OER movement. If we manage to obtain this also for the field of policy by sharing our experiences and lessons learned, fast progression should be possible."
Jude Barback considers the debates around open access and open educational resources.
New Chrome Extension from Net Texts Helps Teachers Access Standards-Aligned, Ready-to-Use Courses Created from OER
Faced with rigorous academic standards and an influx of technology in the classroom, teachers are seeking more efficient, innovative and flexible ways to access and create course materials for their students. To help teachers make the most of their time — inside and outside the classroom — Net Texts today announces the release of a new Chrome extension. Click to Tweet .
Open Badges MOOC - Live session on Monday, June 23, 2-3:00 ET: The Role of Badges in Alternative Credentialing
In response to specific employer/industry requirements and the particular needs of the adult learner, interest in new approaches to credentialing is on the rise. In December, 2013, the U.S. Dept. of Education issued a notice inviting suggestions for new experiments for the Experimental Sites Initiative. The notice expressed particular interest in competency-based education programs and prior learning assessment for postsecondary education. This session will investigate various ways that open badges provide the basis for alternative credentialing programs.
To access the Open Badges MOOC, go to badges.coursesites.com
Mor, Yishay, Mellar, Harvey & Warburton, Steven (eds.) - Practical Design Patterns for Teaching and Learning with Technology - 2014
"Education aspires to bring about change; whether to change individuals and societies, or to change knowledge, attitudes, and practices. The act of devising plans of activities, resources, and tools to achieve such change is an act of learning design. This book sets out to share design knowledge about the use of technology in teaching and learning, and to explore how we might best share this design knowledge amongst educators, but also between educators, researchers, and technology developers."
John Bostock's curator insight, June 17, 8:57 AM
This looks a very interesting collection of papers and open access too!
"During the last 4 years and with a little help of my friends (mostly @leohavemann& @ernestopriego) I collected a large (very large) list of references on OER, Open Education, Open Educational Practices, repositories, open access and related themes which I used to write my PhD and all the papers / columns / presentations we have written, and, basically this lists has been stored in my ref management system for a while, quietly, but suddenly this week I beed asked to share my list of references by few of my fellow OER researchers, so here it is… but before, please read the notes below."
with Download ...
Ebner, Martin et al. (2014). How open content servers can be made beneficial for learning and teaching
From de
Ebner, Martin; Scerbakov, Nicolai & Schön, Sandra (2014). How open content servers can be made beneficial for learning and teaching. In: Transactions on Internet Research, vol.10, no.2 , pp. 26-30, http://vipsi.org/ipsi/journals/
Is the relationship between Open Educational Resources (OER) advocates and traditional educational publishing companies like a playground dominated by bullies? Or more like two groups of kids, ignoring each other as much as possible as they play?
If current activity is any indication, it's a little of both--and neither. The industry is ready to play nicely with OER. But it doesn't appear to know how."
Leigh-Anne Perryman et al.: The role of OER localisation in building a knowledge partnership for development: insights from the TESSA and TESS-India teacher education projects
"OER continue to support the needs of educators and learners globally. However, it is clear that to maximise their potential more focus is needed on reuse and repurposing. Accordingly, adapting OER for local contexts remains one of the greatest challenges of the open education movement, with little written about how to support communities of users to adapt materials.
This paper emerges from the ongoing debate around education quality in low income countries (LICs), taking as its focus two OER projects led by the Open University –TESSA and TESS-India. These projects have collaboratively developed core banks of OERs for teacher education that respond to regional and national priorities and pedagogies. In this paper we explore how the projects have supported localisation of the OERs and how processes of OER localisation can contribute to more equal knowledge partnerships in the pursuit of education quality."
Javiera Atenas & Leo Havemann - Questions of quality in repositories of open educational resources: a literature review
"Open educational resources (OER) are teaching and learning materials which are freely available and openly licensed. Repositories of OER (ROER) are platforms that host and facilitate access to these resources. ROER should not just be designed to store this content – in keeping with the aims of the OER movement, they should support educators in embracing open educational practices (OEP) such as searching for and retrieving content that they will reuse, adapt or modify as needed, without economic barriers or copyright restrictions. This paper reviews key literature on OER and ROER, in order to understand the roles ROER are said or supposed to fulfil in relation to furthering the aims of the OER movement."
From opencontent
"Despite thoughtful disagreement about the term "infrastructure" from people I greatly respect, I continue to find the term extraordinarily useful in my own thinking about how we improve education. As interest in competency-based education continues to grow, we have an incredible opportunity to expand and to open the core pieces of the education infrastructure."
"I'm pretty sure I'm the first person to ever use the iceberg analogy...
From linkis
"Der interdisziplinär ausgerichtete Sammelband befasst sich mit gegenwärtigen Dynamiken und transformativen Prozessen an der Schnittstelle sogenannter Freier Bildungsmedien und Fragen der digitalen Archivierung."
"At the event I worked with a break-out group to map the OER Digital Ecosystem. The following infographic is the QIP visualization of the "ecosystem" derived from a picture of the whiteboard and Felix Tscheulin's gliffy diagram of the same... "
GO-GN stands for Global OER Graduate Network which is a worldwide network of OER PhD researchers and their supervisors. It has been initiated in 2012 and is coordinated by the UNESCO Chair in OER at the Open Universiteit in the Netherlands. Currently GO-GN embraces more than 20 OER PhD researchers from different parts of the world.
"Open source, open science, open data, open access, open education, open learning -- this course provides an introduction to the important concept of openness from a variety of perspectives, including education, publishing, librarianship, economics, politics, and more, and asks you to discover what it means to you. Open Knowledge is international and multi-institutional, bringing together instructors and students from Canada, Ghana, Mexico, the United States, and the rest of the world. It will challenge you take control of your own education, to determine your own personal learning objectives, to contribute to the development of the curriculum, to reflect on your progress, to learn new digital skills, and to take a leadership role in the virtual classroom. It will also provide you with the opportunity to connect with colleagues from different countries and professions, and to better understand areas where your interests overlap and where unexpected distincts exist. We hope you'll consider taking this journey with us."
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Our unique posters and photos will look fantastic in your home, office, hotel, restaurant, etc. Find interior design inspiration from our décor page.
Promoters often created postcard versions of many of their concert posters and used them as promotional mailings. Our postcards are unique, small-format pieces of art that make a fascinating addition to any collection.
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PORTLAND -- Rare shoes from first-time designers had people lining up in downtown Portland Friday—Nike shoes designed by young patients to support Doernbecher Children's Hospital.
Six kids who have been patients at the hospital designed the shoes. Fifth-grader Finn Mooney obviously put his heart into his work.
"I chose red because that is the heart color," he said. "And I chose gold because it gives it a little pizzazz."
"The left side of his heart never grew, so he's had 13 different surgeries to correct that and right now he's doing awesome," said his mother Amy Mooney.
"Finn goes to sleep thinking about his shoe," she added. "He wakes up thinking about his shoe, asking, 'What do you think they're doing with my shoe right now?'"
"These are the stitches on my heart," Finn explained as he admired his design.
All profits from the designs go to Doernbecher.
"It raises money so children can get healthier," said Finn.
Every year Nike relies on doctor recommendations to pick the shoe designers.
"They tell their story through the footwear and sometimes it's their journey at Doernbecher," Nike Creative Director Michael Doherty said.
In nine years of the freestyle design program, the hospital has made more than $5 million and more than 50 once-hurting kids have become celebrities.
"We see kids kind of blossom through this program because they've had an opportunity to talk about what it was like to go through cancer treatment or have heart surgery," said Ashley Schmidt with Doernbecher Children's Hospital.
The Doernbecher freestyle designs range in price from $75 to $175. Finn's creation and one other design released Friday were instantly extremely hard to find.
KGW Reporter Cathy Marshall contributed to this report.


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Driftwood + Starfish Mobile
No longer available
- Overview
Invite the feel of a seaside paradise into your space with this handmade mobile. We collected bright sand dollars and pieces of natural driftwood to create a beach-inspired design that dangles from threads of twine.
- 18" diameter, 36" high
- Frame made of driftwood.
- D-ring at top for hanging.
- Dimensions + Care
- Wipe with a soft, dry cloth.
- Shipping Info
- Please allow 5-7 business days for delivery. Delivery estimate includes monogrammed and gift-wrapped items.
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Final-sale items, identified by a price ending in $0.99, cannot be returned. Once placed, your order for any final sale items cannot be canceled.


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A helicopter contracted for service by the Metropolitan Mosquito Control District crashed into a garage in a Maplewood, Minn., neighborhood Wednesday morning, killing the pilot.
FOX 9 News confirmed 44-year-old Michael Kramer, of St. Charles, was piloting the helicopter owned by Scott's Helicopter Service when it crashed at 8:13 a.m. on the 2700 block of 7th street. He was killed instantly.
"People that do mosquito control, it's a pretty small industry. So, this is a very, very sad day for us," said Jim Stark, of MMCD.
Maplewood Acting Police Chief Dave Kvam said Kramer was the only person inside the helicopter. No other injuries were reported and the owners of the property were not home at the time of the crash.
Police said the helicopter went down in a spiral before hitting the detached garage, but investigators say it is too early to tell what led up to the crash.
Kramer had loaded up and taken off shortly before the crash, and while residents who live near the wetlands where mosquitos often breed are used to seeing the low-flying choppers make their maneuvers, they knew something was different this time.
PHONE VIDEO: http://bit.ly/12KvvSn
MORE PHOTOS: http://bit.ly/13Tcr25
A witness told FOX 9 she heard what initially sounded like a plane flying over her home before she heard a boom and saw smoke and flames coming from her neighbor's garage.
"I thought he was doing some kind of aerial trick or something, then he looked like he was going to do a motion to do a circle in the air, but he didn't pull up," Kristine Pfaff told FOX 9 News. "He just went straight down and he wasn't that high off the trees before that happened."
She immediately called 911 as other neighbors tried to put out the fire with garden hoses.
Other witnesses also told FOX 9 News the aircraft appeared to have problems prior to the crash.
"When I noticed it was struggling to go upwards, I ran to my window and then, all of a sudden, it just kind of turned a little and then ... hit the ground," Tambra Thomas, who captured video of the crash, told FOX 9.
WITNESS INTERVIEW: http://bit.ly/17YbCJO
"I was shaking," said Christine Stenger. "I immediately called 911, not thinking that I would be the first one, but I think I was."
The National Transportation Safety Board is investigating the cause of the crash.
MMCD has operates a fleet of seven helicopters, and they have already treated about 100,000 acres this year. Stark told FOX 9 News accidents like these are extremely rare.
"They've got an exemplary safety record. We've had four incidents that I'm aware of over the last 25 years -- the previous ones I would describe as more of a forced landing," he said. "This is certainly the most significant of the ones I'm aware of."
The Bell 47 has been the workhorse of aerial applications, with pilots using sophisticated GPS technology to track precisely where they've applied chemicals.
"They do fly at relatively lower altitudes, lower air speeds, and they are over a residential community, as you can see," Aaron Sauer, of the NTSB, told FOX 9 News.
While NTSB investigators were at the site within hours of the crash, it could be 6 months or more before they release their findings on what caused the crash. The wreckage of the chopper has been hauled to a secure garage near the company's headquarters in Le Seur. The NTSB will begin to inspect the maintenance records and the aircraft on Thursday.
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"I [have] never seen [any] police around here with [any] guns like that," a neighbor said. "It just didn't seem right." Neighbors say early Friday afternoon two men, one identified as Ezra Gray, a volunteer for the Detroit 300, tried to raid a house to get back what they thought was stolen property. Allegedly they claimed to be police officers and one of them had an antique rifle. "All I heard was, 'I don't have [a] problem with you searching my house, but how you came, I don't who you [are], so you don't have [a] warrant. You're not getting in.'" "It's his house. He's got the right to protect his house," another neighbor said. Neighbors told investigators that the man who lives there was taking care of another neighbor, who recently passed away and that the dying man left few of his belongings as a token of thanks, but his family wanted the stuff back and asked for the Detroit 300 for help. In a statement, the Detroit 300 says, "We do not know all of the facts. Mr. Ezra Gray is a citizen volunteer with The Detroit 300. We do not have a membership. Nevertheless, ALL volunteers with The Detroit 300 must sign a volunteer registration form that clearly states that volunteers must act in accordance with the laws of the State of Michigan and The Detroit 300 By-laws and resolutions. Any volunteer that act contrary to said laws are acting on behalf of themselves and NOT The Detroit 300. The Detroit 300 is organized like volunteers on Angel's Night in the City of Detroit. We ask people to come and help us walk neighborhoods to gather information that will lead to the arrest and conviction of people who commit violent crimes against seniors, women and children. People see us on the street and walk out of their homes and join us. Whosoever will -- let him or her come and help -- and we pray his or heart is in the right place."
On his volunteer registration form, 47-year-old Ezra Gray says he has a concealed pistol license and describes himself as an expert in martial arts, bomb handling and army and firearm tactics.
Neighbors say this could have ended much differently. "It would've been an all out shootout for real because you [come to] somebody's door with a gun talking about you [are] the police when you're really not, you don't know what that man [has] got in his house."
Both men are facing several felony charges, including felony possession of a firearm, felony home invasion and impersonating a police officer, which is also a felony.
WTTG FOX 5 & myfoxdc5151 Wisconsin Ave. NWWashington, DC 20016Main Number: (202) 244-5151Newsroom: (202) email@example.com


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