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LiveRafal Nowak, 31, appears in court over Catherine Wells-Burr death
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- Burnt out car found at 6.30am near A358 at Ashill on Wednesday (September 12) morning
- Body of Catherine Wells-Burr, 23, found in vehicle
- Thousands pay tribute as murder inquiry launched
- Anna Lagwinowicz, 32, of Taunton, appears in court charged with conspiracy to murder Catherine
- Rafal Nowak, 31, also charged with conspiracy to murder
- A 38-year-old man remains in custody
- Family said she was "caring, loving and bubbly"
THIS is the site where the burnt out car was found.
The surface has been re-layed following heat damage.
THE family of Catherine Wells-Burr have released a second statement following her death last week.
Jayne, Phil, Leanne, and all her family have said: "Our beautiful Catherine was inspirational to so many people and touched their hearts.
"We are so shocked, devastated and disappointed by the recent developments.
"Our aim is now to seek justice for Catherine."
A 38-YEAR-OLD man who had been arrested on suspicion of conspiracy to murder Catherine Wells-Burr has been released on bail, detectives said this afternoon.
Two other people - Rafal Nowak, 31, and Anna Julia Lagwinowicz, 32, have been charged with conspiracy to murder and remanded in custody.
YOU can read printed tributes to Catherine Wells-Burr in this week's Chard and Ilminster News - out now - and Somerset County Gazette - out tomorrow (Thursday).
DCI Simon Crisp, who is leading the investigation into Catherine's death, has confirmed detectives believe she was killed in the early hours of Wednesday morning and her body was transported to the A358 at Ashill.
Speaking outside Bristol Magistrates' Court this morning, DCI Crisp said: "We are in possession of information that Catherine died in the early hours of last Wednesday."
RAFAL Nowak has been remanded in custody after a brief appearance at Bristol Magistrates' Court this morning.
Mr Nowak, 31, of Willow Way, Chard, was dressed in a checked shirt and jeans and spoke only to confirm his name and address during the brief hearing.
He is charged with conspiracy to murder his girlfriend Catherine Wells-Burr, who he lived with at the address in Willow Way.
He was remanded in custody and will next appear at Bristol Crown Court on October 9 - the same date as co-accused Anna Julia Lagwinowicz, 32, of South Street, Taunton.
OUR reporter says Catherine's boyfriend Rafal Nowak is expected to appear in the dock at Bristol Magistrates' Court within the next 30 minutes.
Other cases are being dealt with first.
POLICE were stationed by the side of the A358 near Ashill this morning exactly one week after the discovery of Catherine Wells-Burr's body in a Ford Focus.
Officers were hoping motorists driving past the scene may have seen a suspicious vehicle or person at the site seven days earlier.
MOTORISTS driving along the A358 tomorrow morning will be asked to cast their minds back to Wednesday, September 12 when the body of Catherine Wells-Burr was found.
Drivers who have any information are being asked to report it to officers who will be at the location near Ilminster between 5am and 7am.
A community contact vehicle will also be at the location so drivers can leave their details with police.
DCI Simon Crisp, the officer leading the investigation, is keen to hear from anyone who may have been in the area at the time, particularly anyone who saw a red Ford Focus 5 door hatch back with another vehicle.
He said: "I would ask people to think back to last week. Where were you going that morning and does anything from your journey stick in your mind? Did you see anything suspicious or out of the ordinary? Please stop and speak to my team, or leave your details and we will get back in touch."
Two people have been charged with conspiracy to murder in connection with Catherine's murder.
Anyone with any information is asked to contact police on 101 or call Crimestoppers on 0800-555111.
THE boyfriend of Catherine Wells-Burr has been charged with conspiring to murder her.
Rafal Nowak, 31, (above) is due to appear at Bristol Magistrates' Court tomorrow morning (Wednesday).
A 38-year-old man who was also arrested in connection with the incident remains in police custody where he is being questioned.
OFFICIALS at Bath Spa University have spoken of the sorrow at the site following the death of graduate Catherine Wells-Burr.
A spokesman said: "Bath Spa University is deeply saddened about the death of graduate Catherine Wells-Burr.
"Catherine graduated in 2011 with a first class honours degree in Business and Management and will be fondly remembered by all those here who knew her.
"Our heartfelt sympathy and sincere condolences are with Catherine's family at this distressing and difficult time."
A WOMAN has appeared in court charged with conspiring to murder Catherine Wells-Burr.
Polish national Anna Julia Lagwinowicz, of South Street, Taunton, spoke only to confirm her name and address via an interpreter during a 10-minute hearing at Bristol Magistrates Court.
The court heard Ms Lagwinowicz, who appeared in the dock wearing a dark t-shirt and dark trousers, is the former partner of Catherine's boyfriend Rafal Nowak.
Ms Lagwinowicz was remanded in custody and will next appear at Bristol Crown Court on October 9.
ANNA Julia Laqwinowicz, 32, is due to appear at Bristol Magistrates Court (pictured) this morning charged with conspiracy to murder 23-year-old Catherine Wells-Burr.
Catherine's body was found in a burnt-out car in Ashill, between Chard and Taunton, last week.
Our reporter will be in court for the hearing - keep checking back to this story for the latest updates.
A 32-YEAR-OLD woman has been charged with conspiracy to murder in the investigation into the death of Catherine Wells-Burr.
Anna Julia Laqwinowicz was arrested on Thursday in connection with Catherine's death and has remained in police custody since.
She is due to appear at Bristol Magistrates Court tomorrow morning (September 18).
Two men have also been arrested - a 31-year-old and a 38-year-old are in police custody and are still being questioned.
DCI Simon Crisp, who is leading the inquiry, said: "I am still extremely keen to speak to a number of people who have not yet come forward.
"We know that there were many motorists that passed the site of this crime on Wednesday morning, and those people may have information that could help us. I would ask that you come forward and speak with us no matter how small you think your information may be, please let us decide.
"It is also important that we speak with anyone who may have been in the area between 3am and 6am on Wednesday, using the roads between Chard and Ashill (the A358). Did you see a red Ford Focus, 5 door hatch back that may have been in company with another vehicle? If you did, please contact us."
Anyone with information is asked to call police on 101 or call Crimestoppers on 0800-555111.
AN update on the 32-year-old suspect being questioned by detectives is expected later this evening, police have said.
TRIBUTES continue to pour in for Catherine Wells-Burr.
The Facebook group, which can be viewed here , now has more than 7,500 members.
Donna Sell posted: "I give all my thoughts and condolences to all Catherine's family and friends, may you rest in peace you beautiful girl, a star in the night sky will be brighter now with u above, sleep well princess and such a sad and terrible tragedy for anyone, love to all that knew her xxx."
Among the other messages, Jacacia Totterdell said: "RIP cousin xxxxx" and Phil Man posted: "Losing a loves one is hard, but knowing God gained an angel makes the grief a little easier. RIP Catherine x."
DOZENS of floral tributes have been laid at the site where the body of Catherine Wells-Burr was discovered last week.
A TRIBUTE page set up on Facebook in memory of Catherine Wells-Burr now has almost 7,500 members.
Sarah Arnold, who was among the friends leaving floral tributes near the scene on the A358, posted: "We were all united in remembering our Caf. So pleased with who else was there tonight, it was all the right people.. Will remember it always ♥ xxx."
Tracey Whatley added: "R.I.P sweetie taken away so young. My condolences to the family and friends of Catherine. Sweet dreams the angels will take care of you xx."
7:38pm Sat 15 Sep 12
benoverd says
Everyone misses caff so so much....we all love you little angel xx
DETECTIVES have been quizzing a 32-year-old woman over the death of Catherine Wells-Burr all weekend.
They were given extra time to question the suspect on Saturday after the initial arrest a day earlier.
A decision on whether she will be charged or not is expected later today (Monday).
POLICE are still at the scene in Ashill sealing off the road that leads to the scene where the car was found.
Floral tributes to Catherine Wells-Burr have also been laid at the cordon.
There is a police presence along the A358 past the area.
CHARD United Football Club paid tribute to Catherine Wells-Burr with a one minute silence ahead of their game yesterday (Saturday) at Jocelyn Park.
1:08pm Sat 15 Sep 12
benoverd says
I can truely say this is the first time in my whole life that ive felt so lost and upset.Not only is it well beyond upsetting and shocking but a wonderful friend has been lost.Ive known catherine for 6 years and in that time we have shared memories that will never ever be forgotten. I will always remember her 18th birthday where friends and family met to celebrate. Ive never seen a bigger smile on her face.Catherine had a heart of gold. She was an intelligent and bright young woman who had so much going for her. She thrived on doing well and always put her friends and family first.Like all will agree caff will never be forgotten. Gone from out home but not from our hearts.Let the police do their job to find the evil person who took caff away from us all.Id like to send all my love to her family and friends and ask everyone to think of the great times they spent with her.R.I.P Catherine. I love you very much....and you will be missed by all
6:54pm Fri 14 Sep 12
somersetgirl says
I found out this horrible news while I was on holiday. I worked with Catherine at Numatics and will always remember when I was having a bad day she was always there to make me smile. I've known Catherine since she was about 11 and I worked in tescos and she would come in with her dad and sister. I cant believe she has been taken away from us and she will be missed by so many. My thoughts are with her family xx
DETECTIVES have been given a further 36 hours to question the 32-year-old woman arrested on suspicion of murdering Catherine Wells-Burr.
They have also released more details about Wednesday morning.
Police want to speak to the driver of a dark coloured people carrier they think was travelling from Ilminster to Taunton past the scene at around 6.10am.
Officers believe the car braked at the point of the fire.
DCI Simon Crisp said: "I would also like to speak to anyone who saw a white transit or smaller van or was in a white transit or smaller van that was parked in the vicinity of the scene.
"My final appeal is to members of the public who saw anyone in the area wearing a high visibility jackets, these people may have information that is significant to this investigation."
Anybody with information should contact Crimestoppers on 0800-555111.
CATHERINE Wells-Burr's employers Numatic International, based in Chard, have released this statement: "Catherine was a valued employee who worked with us in manufacturing during her university holidays and after graduation as a full time employee.
"She moved to our IS department last year to further her career as Business Analyst.
"We are all shocked and saddened by this tragedy and our thoughts are with Catherine's family and all those affected."
Numatic is best known for making the Henry vacuum cleaners.
If you work at Numatic and would like to leave a tribute to Catherine, add your comments using the form at the bottom of this page and we will aim to publish them in Wednesday's Chard and Ilminster News.
THE family of Catherine have described her as an "amazing and special person."
A statement by mum Jayne, dad Phil, sister Leanne and boyfriend Rafal (pictured above with Catherine), said: "We have lost our beautiful Catherine; she was full of character, she was caring, loving, and had a bubbly personality.
"She had a wonderful sense of humour, and was an amazing, special person.
"Catherine had achieved so much in her short life and had worked so hard to gain her Bachelor of Honours in Business Management, gaining a first class degree from Bath Spa University.
"She was so happy starting her life with Rafal and excited about their future together.
"We would like to express thanks for all the messages of sympathy and support, we have found some comfort in all the kind and thoughtful words that have been said about Catherine and in knowing how well she was loved.
"We have found this hard to understand why someone would have done this to her.
"There are no words to express how we feel about what has happened to her early on Wednesday morning. We desperately need to know why.
"She will be sadly missed."
12:08pm Fri 14 Sep 12
ChrisPowell says
Caf was a very close friend of ours. We will miss her VERY much. A Facebook page has been set up by some of her friends in memory of her. This can be found at http://www.facebook.
com/RIPCatherine.The Twitter hashtag #RIPCatherine is being used for people to pay their respects online also.
THE picture below has been created by friends since Catherine's death.
They asked us to post it on their behalf.
CHARD Mayor Cllr Cathie Morrison, below, said she was "deeply shocked" by Catherine's death.
She added: "All I can say is I was deeply shocked when I heard the news. I feel for Catherine's family and for everybody who knew her.
"Having spoken to the town council we would like to express our sympathy to the family at this difficult time."
MORE than 4,200 people have now joined a Facebook page set up in memory of Catherine Wells-Burr.
Among the messages posted on the site, which can be viewed here , is this poem from Sean Smith:
Words say nothing
Now that you're gone
We fall to the floor.
There's no meaning
To why you are gone
It just hurts to the core.
Thursday morning
...The news opened our eyes
Took our breath away.
At first unnerving
Tears rolled from our eyes
To see you taken away.
We didn't lose a life
We just gained an angel.
You oozed such life
You won't leave a stranger.
Our hearts are aching
As we wait in the cold
The answers lie waiting
Where the truth will unfold.
A brighter star shines from above
All that we ask is you share the love
Stay strong and try to dry those eyes
Catherine wouldn't want to hear us cry.
THE family of Catherine Wells-Burr have released a photograph of her taken at her graduation ceremony.
The body of Catherine, 23, who studied at Bath Spa University, was found in a red Ford Focus on Wednesday morning.
A WOMAN has been arrested in connection with the death of Catherine Wells-Burr, police said today.
A 32-year-old woman was arrested last night (Thursday 13) on suspicion of murder and is now in police custody.
Two men who were also arrested have since been eliminated from the inquiry, police said.
DCI Simon Crisp said: "A post mortem will begin today to try and identify how Catherine died.
"We still need information from members of the public and those people who knew Catherine or knew of her.
"It is imperative we get a full picture of her life and you may have information that could help."
DCI Simon Crisp, who is leading the investigation into the murder of Catherine Wells-Burr, has pledged to catch her killer.
He told reporters: "I can assure you we will find those responsible and bring them to justice."
Heart goes out to catherines family.at this awful time #R.I.P #catherinewellsburr— @BigCowdrey 13 September 2012
Absolutely horrific news can't believe somebody would do that #RIPCatherine #ashill #catherinewellsburr— @Gov_the_gunner 13 September 2012
Officer investigating murder of Catherine Wells-Burr says 'we will catch her killer' - http://t.co/sOph3LUV #catherinewellsburr— @GazetteAMcGill 14 September 2012
CATHERINE Wells-Burr
THOUSANDS of people have taken to social networking site Facebook to leave messages on a tribute page to Catherine.
The group, R.I.P Catherine Wells-Burr, was only set up last night (Thursday) but already has over 3,500 members.
Mo Symons posted: "This is so awful. My thoughts are with all of her family and friends. A young beautiful woman taken. I pray that the person who did this is found and brought to justice. RIP to a lovely young woman."
Steve Clarke said: "Such a waste of a young life. R.I.P Catherine."
Mark Jeffries put simply: "Heaven has got a new angel."
And commenting on the amount of group members, Leanne Michelle said: "She deserves every single one - proves how loved she is x."
OFFICERS continued to search the area around where Catherine's body was found late into Thursday afternoon.
4:51pm Thu 13 Sep 12
Tauntonjams says
I am deeply saddened by a loss of a other person from my home county.
I was lucky enough to meet Catherine's aquaintance once or twice and she was a lovely girl.
What I'm even more shocked about is how Somerset is going down hill. I work away from the area 9/10 months a year and when ever I check back in the news, always some tragedy or death. People these days make me sick.
I'm just glad I'm far away from it all.
RIP Caf, best wishes and condolences to all her family and close friends
3:08pm Thu 13 Sep 12
timmybadger says
I'm in complete shock at this tragic news. Catherine (or Caf as she was known by many) was such a sweet, beautiful person.
I feel so sad for her friends and family. x
THIS is a picture of murder victim Catherine Wells-Burr, whose body was discovered in a burnt-out car in Ashill yesterday (Wednesday) morning.
DCI Simon Crisp speaks to the media at Taunton Police Station on Thursday, September 13.
FULL statement from DCI Simon Crisp: "The person that died in the car yesterday at Ashill was Catherine Wells-Burr. We believe it to be her but formal identification is yet to take place.
"I am making a double appeal today. Firstly for those people that may have witnessed Catherine and her red Ford Focus arriving at the scene which is alongside the A358 near Ilminster.
"Did anybody see that car arrive? Did anybody see suspicious people arrive or leave the scene at about 6am to 6.30am on a busy road? We need you to call us.
"The second part of the appeal is to help us understand Catherine's private and social life.
"Did she know her killer is the question that we're asking ourselves. Did she arrange to meet somebody at the location where she met her death? These are the things we are seriously considering.
"Please don't leave it to others to tell us, call us immediately.
"The post mortem examination is yet to take place so I am unable to confirm whether she died in the fire or beforehand.
"I believe we are still searching for the offenders. At this moment there is not a specific person we are looking for.
"We are working on the theory that she possibly knew the attacker. We do not think this is a random attack but we are not ruling it out."
SPEAKING at Taunton Police Station this afternoon, DCI Simon Crisp, below, said detectives believe Catherine may have known her attacker.
He said: "We are working on the theory that she possibly knew the attacker."
Full statement to follow...
IN a statement, Catherine's former school, the Holyrood Academy in Chard, has said they are 'deeply shocked and saddened' at the news of her death.
It read: "She is warmly remembered as a very friendly young person, gregarious and with a great sense of humour.
"Catherine always had a smile and a positive outlook. Our sincere condolences go to her family and friends at this difficult time."
A MEDIA briefing on the Catherine Wells-Burr murder inquiry is about to get under way.
WRITING on Facebook, former Holyrood School pupil Chris Powell has paid tribute to Catherine.
He wrote: "Catherine Wells-Burr - Can't believe what I'm hearing.
"You always had a smile on your face, always took the time out to talk to and advise people putting them before yourself.
"We were so so close in school... How anyone could do such a thing to someone so harmless and beautiful - inside & out, is something I will never understand.
"R.I.P babe. Thinking of you and your family."
THE scene of the discovery:
THE officer in charge of the investigation - DCI Simon Crisp - is the same policeman who led the inquiry into the murder of Rev John Suddards in Thornbury, near Bristol, earlier this year.
CATHERINE Wells-Burr's body was found in a red Ford Focus, police have said.
LOCATION of body discovery
FULL statement from DCI Simon Crisp:
"This is a tragic and brutal incident in which a young woman has needlessly lost her life.
"We are working to establish what happened in the early hours of yesterday morning that led to this car being set ablaze.
"I would like to appeal to anyone with any information about this incident to get in touch with us no matter how small you think that piece of information may be.
"In particular I'd like to speak to any motorists who were in the area around the time who may have seen anyone acting suspiciously or anyone crossing the A358. It is also very important that we speak to all of Catherine's friends and associates who she may have socialised with, as well as anyone else who may have any knowledge about her social and private life.
"Your information may be crucial so please contact us by calling 101 or Crimestoppers on 0800-555111.
"Finally I would like to thank local residents for their cooperation as we carry out this investigation and also those motorists who have been inconvenienced because of the road closures."
DCI Crisp will further address the media at Taunton Police Station this afternoon.
THE woman has been named as 23-year-old Catherine Wells-Burr.
Detective Ch Insp Simon Crisp said: "This is a tragic and brutal incident in which a young woman has needlessly lost her life.
"We are working to establish what happened in the early hours of yesterday morning that led to this car being set ablaze."
THE discovery of the woman's body is being treated as murder, police have confirmed this morning.
POLICE are treating the discovery of the body in a car this morning in Ashill as suspicious.
Fire crews discovered the woman's body in the car after being called to the incident shortly before 6.30am.
Anyone who was in the area at the time and believes they may have any information is asked to contact police on 101 or Crimestoppers anonymously on 0800-555111.
POLICE were called to reports of a car on fire shortly before 6.30am this morning (September 12) in a field off the A358.
The fire service was called and confirmed that there was a body in the car.
Police enquiries are continuing in the area at the end of Thickthorn Lane, leading to Southtown and Hastings.
Officers have confirmed they are keeping an open mind and treating the death as unexplained until a post mortem is held to determine the cause.
A BURNT out vehicle has been found in Thickthorn Lane off the A358 in Ashill.
A number of police and fire crews have been seen in the area and are currently investigating the incident.

subset: commoncrawl


text:
By Maurielle LueFox 2 NewsDETROIT (WJBK) -- "He was like, 'Get on the ground,' and we laid down. And they're like, 'What y'all got?' And my cousin, he was like, 'We ain't got nothing.' And that's when they kicked him the eye, then they asked me, 'What y'all got?' and shot my brother twice."18-year-old True Whitsey was killed right in front of his baby brother. The brothers were leaving their sister's house with a friend when they were approached by two men in a red Focus. They were robbed and True was shot in the back and on his side. He died at the hospital."Why my baby? He was just a college kid home visiting from school," said mother Tamika Brown. "He wasn't [a] bad kid."His mother boasts of her son's 4.0 GPA all through high school. He had a full, four year scholarship to Ferris State where he planned to study corporate law -- a bright, young mind with the world at his feet."That was the worse thing I ever [did] in my life, to identify my baby on the screen," Brown said. "They killed both of my sons. They took one life and messed the other one's mind up. He had to witness his brother's death. It don't get [any] worse than that."True's baby brother said there was something that will make the shooter easy to find."He had a tattoo... on the corner of his right eye."True's mother is planning a candlelight vigil on Joy and Stahelin Saturday night at 6:45. She wants the entire community to show up and support her son.
True Whitsey was mentored by Detroit City Council President Charles Pugh. He released a statement Friday saying, "He was a well mannered young man with goals. I am heartbroken, and it makes me want to double my efforts to save our city by helping not just those who are college bound... but to catch those in enough time to stop them from being prison bound."
WFTC-TV11358 Viking DriveEden Prairie, MN 55344Phone: (952) 944-9999Fax: (952) 942-0455


text:
If you love camping or have always been interested in RV travel, there's a great opportunity to see what's new out there this weekend.
The Valley RV and Camping Show started Friday at the Century Center. Seven of Indiana's top dealers will there featuring more than 70 units ranging from small pop-up campers to full motor homes.
It's a great opportunity for first timers trying to figure out what best suits them and to compare prices, whether you're buying your first RV or looking to upgrade.
"They are looking to see what the latest and greatest is," says organizer Matt Rose. "This is their first look at the 2013 models. There's a lot of new things on the market. Units are becoming lighter so they are more energy efficient, saving in fuel costs."
Rose says the dealers are offering special show pricing and many will store the unit you buy until the weather breaks and you can use it. The show runs through Sunday.
WSJV-TV FOX 2858096 County Road 7, SouthElkhart, IN 46517
Switchboard: 574.679.9758News Phone: 574.679.4545Station Fax: 574.294.1267Email: firstname.lastname@example.com


text:
Breast Cancer Test May Aid Patients with Affected Lymph Nodes
A genomic test may help some women with early-stage breast cancer gauge the risk of a recurrence and the potential benefit of additional chemotherapy even when the disease has spread to the lymph nodes, researchers are reporting.
The test, OncotypeDX, profiles the activity of 21 genes in a tumor and quantifies the risk of a recurrence over 10 years, assuming the patient receives 5 years of hormonal therapy such as tamoxifen.
Making Progress in Difficult Times Will Require a Collective Effort
"No individual is alone responsible for a single stepping stone along the path of progress." This remark by Nobel Prize winner Ernest Lawrence comes to mind as we take stock of all that happened during this past year in cancer research.
In 2007, NCI put on full display the teamwork, collaborative effort, and maturation of scientific knowledge that, even in a time of constrained resources, helped ensure steady progress - with one discovery building on another. Certainly the Institute was forced to make some tough choices in order to redirect a less-than-inflation allocation of federal dollars toward our highest priority programs. Even with those limited resources, NCI's scientific accomplishments this past year were, to say the least, impressive. Read more
Breast Cancer Test May Aid Patients with Affected Lymph Nodes
A genomic test may help some women with early-stage breast cancer gauge the risk of a recurrence and the potential benefit of additional chemotherapy even when the disease has spread to the lymph nodes, researchers are reporting.
The test, OncotypeDX, profiles the activity of 21 genes in a tumor and quantifies the risk of a recurrence over 10 years, assuming the patient receives 5 years of hormonal therapy such as tamoxifen.
Many physicians have used the test to help identify women with estrogen receptor (ER)-positive disease that has not spread to the lymph nodes whose risk of a recurrence is so low that they might not benefit from additional chemotherapy after surgery.
Now, researchers say the test could also predict which postmenopausal women with node-positive, ER-positive disease would benefit from adjuvant chemotherapy and define a group for whom chemotherapy does not appear to be beneficial.
"This test allows physicians to discover the biologic profile of an individual cancer and treat the patient accordingly," said Dr. Kathy Albain of the Cardinal Bernardin Cancer Center of Loyola University Chicago, who presented the findings last week at the San Antonio Breast Cancer Symposium. The test could be an aid right now in making treatment decisions for certain patients, but should be used selectively, she said.
The study, led by the Southwest Oncology Group, used tumor samples from 367 women who had been treated either with tamoxifen alone or with anthracycline-based adjuvant chemotherapy followed by tamoxifen. A high "recurrence score" predicted a high risk of recurrence and a large benefit from chemotherapy, while a low recurrence score identified a group of women who did not seem to benefit from the added chemotherapy.
Even though the test identified a group with the lowest risk of recurrence in the study sample, there still was a 40 percent rate of recurrence at 10 years in the subset. "This tells us that these patients with positive nodes and low recurrence scores need a different treatment strategy that will improve the 10-year outcomes," said Dr. Albain.
The results confirm previous studies involving node-negative disease and slightly different chemotherapy regimens. "A general picture is emerging that this test is able to distinguish patients who appear to likely benefit from chemotherapy," said Dr. Peter Ravdin of the University of Texas M.D. Anderson Cancer Center and a coauthor of the abstract. "And that's exciting."
Many in the field have wondered whether all node-positive breast cancers are the same or whether physicians should be trying to individualize treatment. "This study showed that even in node-positive breast cancer, all women do not benefit equally from chemotherapy," said coauthor Dr. Steven Shak of Genomic Health, which makes the test.
The findings support the fact that biology is the most important predictive factor for a benefit from chemotherapy since the recurrence scores are predictive in patients with both node-positive and node-negative disease, said Dr. Sandra Swain of the Washington Cancer Institute at the Washington Hospital Center in the District of Columbia, who attended the presentation.
"It's very exciting to have a test like this," she added. "We are beginning to home in on the true biology of the tumor and think critically about which patients need treatment."
The study was small and needs to be confirmed. More research is also needed to determine whether commonly available biological markers such as the gene HER2/neu and the estrogen receptor could provide essentially the same information about responsiveness to chemotherapy as the gene signature, according to Dr. Ravdin.
Classical biological factors might be a simpler and less expensive way to achieve the same result, said Dr. Ravdin, noting that the test costs approximately $3,500. "We owe it to our patients to explore this question further."
The researchers plan to publish the findings next year, including data on the use of combinations of classical biological markers in these patients.
— Edward R. Winstead
Making Progress in Difficult Times Will Require a Collective Effort
"No individual is alone responsible for a single stepping stone along the path of progress." This remark by Nobel Prize winner Ernest Lawrence comes to mind as we take stock of all that happened during this past year in cancer research.
In 2007, NCI put on full display the teamwork, collaborative effort, and maturation of scientific knowledge that, even in a time of constrained resources, helped ensure steady progress - with one discovery building on another. Certainly the Institute was forced to make some tough choices in order to redirect a less-than-inflation allocation of federal dollars toward our highest priority programs. Even with those limited resources, NCI's scientific accomplishments this past year were, to say the least, impressive.
In 2007, our genome-wide association studies (GWAS) validated and placed a remarkable amount of data into the public domain. GWAS is a truly collective effort that pools data from researchers studying large patient cohorts in order to identify common genes that confer modest amounts of cancer risk. These germline sites in our DNA, which are predictive of increased risk, act collectively, not alone. GWAS studies will help identify new environmental factors and biological mechanisms of disease as we layer onto GWAS data the genetic changes that accumulate during one's life. These genetic data, carefully analyzed and constructed, will be valuable resources in identifying new prevention and treatment strategies. GWAS studies published this year - several sponsored by NCI's Cancer Genetic Markers of Susceptibility project - identified common genetic variants that show increased risk of developing breast, prostate, and colorectal cancers, along with one germline region that appears to be protective against the development of breast cancer.
In another important area of cancer research, cancer biologists this year worked to test the hypothesis that within each tumor there is a small subpopulation of cells with the genetic properties of tissue stem cells. Some refer to this population as "cancer initiator" cells, and evidence supports their potential importance both in the resistance of tumors to therapy and in the process of metastasis. Therapeutic approaches that specifically target this subpopulation of cells are now being combined with standard anticancer regimens. Early clinical trials include a compound called DMAPT that NCI's Rapid Access to Intervention Development program is helping researchers to investigate, through an approach that "awakens" these quiescent cells to make them more sensitive to existing therapies.
Representing a highly leveraged team project was the launch in June of the NCI Community Cancer Centers Program (NCCCP). Focusing on underserved communities and groups that are disproportionately affected by the disease, the NCCCP's pilot phase involves 16 community hospitals working with NCI to identify the best research-driven strategies for delivering state-of- the-art cancer care in the community, where the large majority of cancer patients receive care close to home. The research conducted through NCCCP will help NCI bring early-phase clinical trials to such settings, explore development of electronic medical records, and enhance our ability to practice highly personalized cancer care. The ultimate goal is to ensure that all people, no matter where they live, no matter what their education or economic status, will have equal access to our latest science.
There was no absence of significant clinical advances this year, including the introduction of the phase 0 clinical trial at the NIH Clinical Research Center. Made possible by an extensive NCI-FDA partnership that resulted in the creation of the FDA Exploratory IND Guidance, these early studies use pharmacodynamic measurements or imaging to find the biologically effective dose for first-in-human studies of newly developed therapeutics. This new approach has already demonstrated its ability to significantly shorten the drug discovery process.
Another important clinical trial highlighted the significant contributions of imaging to cancer diagnosis and care, demonstrating that adding MRI to standard mammograms detects virtually all cases of contralateral breast cancer. A separate patient study provided a potentially important clarification about the use of finasteride to prevent prostate cancer in high-risk men.
We continue to make progress against specific forms of cancer. For example, this year began a new era for the treatment of advanced liver cancer, which had previously been impervious to new treatments. In yet another difficult-to-treat cancer type, small-cell lung cancer, researchers demonstrated that prophylactic cranial irradiation not only reduced the risk of symptomatic brain metastases, it also improved survival.
In financially constrained times, such as the NIH has experienced over the past 4 years, we are placing a greater emphasis on collaboration and finding ways to leverage scarce resources through cooperative external investment. None of that would be possible without NCI's senior leadership, who time and again this year worked together to make difficult funding and priorities decisions. These decisions were made with the utmost integrity, based on a belief that, regardless of the challenges or obstacles before us, we must work even harder - certainly with more collaboration and innovation - to support the best science. In 2008, we will continue moving forward one stepping stone at a time as we navigate this path on behalf of our patients.
Dr. John E. Niederhuber
Childhood Cancer Death Rates Decline
Improvements in the treatment of childhood leukemias have contributed to a decline in cancer death rates among U.S. children and adolescents from 1990 to 2004, researchers from the U.S. Centers for Disease Control and Prevention reported in the December 7 Morbidity and Mortality Weekly Report.
"The good news is that the overall cancer death rates decreased significantly during this period in boys and girls, children and adolescents, most racial and ethnic groups, and all U.S. Census regions," said co-author Dr. Jun Li.
Using data from the National Vital Statistics System, the researchers identified 2,223 cancer deaths among children and adolescents in 2004, compared with 2,457 in 1990. Adjusted for population growth, this translates into 27.3 cancer deaths per million in 2004 versus 34.2 deaths per million in 1990. In 2004, leukemia was the leading cause of childhood cancer deaths, followed by brain and other cancers of the nervous system. Together, these accounted for more than 50 percent of the deaths.
"We really have made a lot of strides in treating leukemias, and this is reflected in the improvements we are seeing," said co-author Dr. Loria Pollack. She noted, however, that children are still dying from these devastating diseases and more progress is needed.
Between 1990 and 2004, death rates for leukemias declined by 3 percent per year, for brain and other nervous system cancers by 1 percent per year, and for all other cancers combined by 1.3 percent per year. Meanwhile, incidence rates for all childhood cancers increased by 0.6 percent per year from 1975 to 2002. Cancer is the fourth-leading cause of death among children and adolescents, after accidents, homicides, and suicides.
The analysis revealed some disparities. Hispanics and non-Hispanics had similar childhood cancer death rates in 1990, but these rates declined more rapidly for non-Hispanics than Hispanics between 1990 and 2004. Lack of health insurance and access to health care may be factors, but differences in tumor aggressiveness, cancer stage at diagnosis, and response to treatment also should be considered, the researchers said.
Mediterranean Diet and Physical Activity Associated with Lower Death Rates
Separate analyses from the NIH-AARP Diet and Health Study indicated significant reductions in the overall death risk for people who adhere to the so-called "Mediterranean diet" as well as among those who engaged in physical activity levels suggested by national exercise guidelines, according to two studies published in the December 10/24 Archives of Internal Medicine.
The NIH-AARP study was developed by an NCI research team that is now part of the Division of Cancer Epidemiology and Genetics (DCEG). The study monitored the health status of more than 500,000 AARP members in the U.S. aged 50-71 from 1995 to 2005 using mailed questionnaires, death records, and tumor registry data.
In the first study, researchers used a 9-point scale to assess adherence among 380,296 healthy AARP members to the Mediterranean dietary pattern, which includes high intake of vegetables, legumes, fruits, nuts, whole grains, fish, higher intake of monounsaturated than saturated fat, moderate alcohol consumption, and low red meat intake. The dietary pattern was associated with a 21-percent decreased risk of all-cause mortality (17 percent for cancer deaths and 22 percent for cardiovascular deaths) in men, and a 20-percent decreased risk of all-cause mortality (12 percent for cancer deaths and 19 percent for cardiovascular deaths) in women. The beneficial effect of the Mediterranean dietary pattern was more pronounced in smokers, especially those with a healthy body mass index.
In the second study, researchers examined the effect of adherence to national guidelines for both "moderate" and "vigorous" physical activity among 252,925 AARP members. Compared with inactive, sedentary respondents, people who engaged in moderate exercise (at least 30 minutes, most days of the week) had a 27-percent decrease in overall mortality, and those who exercised vigorously (at least 20 minutes, three times a week) reduced their death risk by 32 percent.
"Our findings strongly confirm the importance of these national physical activity guidelines," noted study leader Dr. Michael Leitzmann of DCEG's Nutritional Epidemiology Branch. A secondary finding showed that even those individuals who engaged in physical activity at less than the guideline recommendations had a reduced mortality risk.
DCEG is pursuing additional research on physical activity, Dr. Leitzmann added. "We're now drilling down to the effect of exercise on specific forms of cancer. Those impacts may differ from that on total mortality," he said.
Allogeneic Transplant Does Not Increase Survival in High-Risk ALL
In a collaborative clinical trial from the UK Medical Research Council and the U.S. Eastern Cooperative Oncology Group, adult patients with standard-risk Philadelphia-chromosome-negative acute lymphoblastic leukemia (ALL) had significantly increased overall survival after high-dose, chemotherapy-induced first remission followed by allogeneic stem cell transplantation. However, while patients with high-risk ALL had a decrease in the risk of relapse with allogeneic transplantation, their overall survival did not significantly increase, due to the high rate of transplant-related mortality.
"Surprising though it might appear, the high-risk patients benefit less from having a donor than the standard-risk patients in terms of overall survival," state the authors in their paper published online November 29 in Blood. "This is an important finding since there is often a view that high-risk patients should go immediately to allogeneic transplant."
The trial also tested autologous (self) transplantation versus maintenance chemotherapy for patients who did not have a matched sibling donor available for allogeneic transplantation. Unmatched patients who went into remission after the initial high-dose chemotherapy were randomly assigned to receive either autologous transplantation or 2.5 years of maintenance chemotherapy.
Those patients receiving chemotherapy had significantly improved overall survival compared with patients undergoing autologous transplantation, and there was no significant difference in nonrelapse (i.e., treatment-related) mortality between the two groups. However, in an analysis comparing all patients with a donor versus those without a donor, those with a donor had better overall survival rates.
"Sibling donor allogeneic transplant is the treatment of choice for adults with standard-risk ALL in remission providing the greatest chance for a long-term survival. Autologous transplant has a less favorable outcome than consolidation/maintenance chemotherapy for those without a donor," conclude the authors.
Trials Demonstrate Investigational Compound's Chemoprevention Potential
A combination of the investigational compound DFMO with low doses of the anti-inflammatory agent sulindac may be a powerful chemopreventive approach in people at high risk of developing colorectal polyps, researchers reported last week.
The combination of the two drugs significantly decreased the formation of new colon polyps, including advanced polyps, compared with placebo. The 375 participants in the phase III, double-blind, randomized trial all had previously had colon polyps removed.
The results were presented during a session on cancer prevention clinical trials at the American Association for Cancer Research's (AACR) fourth annual Frontiers in Cancer Prevention Research meeting in Philadelphia.
The trial was stopped early, following a recommendation of its Data Safety Monitoring Board, because its primary goals had been met, explained lead investigator Dr. Frank L. Meyskens from the University of California, Irvine. Toxicities - including audiologic toxicities, a concern raised in earlier studies of DFMO - were minimal and similar between the two trial arms.
Results from a subgroup analysis of a different phase III trial investigating DFMO for the prevention of nonmelanoma skin cancer were also presented at the same AACR meeting session, demonstrating a significant protective effect against basal cell carcinoma.
Bortezomib Tested as First-Line Treatment for Multiple Myeloma
At last week's annual meeting of the American Society of Hematology, researchers announced results of several phase III European clinical trials testing the drug bortezomib (Velcade) as a first-line treatment for multiple myeloma. Bortezomib is currently approved in the U.S. as a second-line treatment for the disease.
One multicenter study involved 482 patients who were randomized to receive either a combination of bortezomib and dexamethasone or a combination of vincristine, doxorubicin, and dexamethasone, followed by transplantation with allogeneic stem cells. The results showed that 21 percent of patients who received the bortezomib regimen went into complete disease remission before transplantation, whereas only 8 percent did so in the control group. Of the 404 patients who went on to receive stem cell transplantation, 41 percent in the bortezomib group were in complete remission, compared with 29 percent in the control group.
Another study included 256 patients who were randomized to receive bortezomib, thalidomide, and dexamethasone, or thalidomide and dexamethasone alone. Patients in the test group showed 36 percent complete remission before stem cell transplantation, whereas 9 percent of patients had complete remission in the control group. After stem cell transplantation, the complete remission rates were 57 percent versus 28 percent, respectively.
A third study, named VISTA, involved 682 patients who were ineligible for allogeneic stem cell transplantation. In the test group, which received bortezomib, melphalan, and prednisone, 35 percent of patients went into complete remission, compared with 5 percent in the control group who received melphalan and prednisone alone. The bortezomib group also saw a 40-percent lower risk of death compared with the control group.
Cervical Cancer Screening Approach Slowly Shifting
Ask Dr. Mark Schiffman about the strategy behind screening for cervical cancer and he'll tell you it boils down to one thing.
"It all comes back to an underlying knowledge of persistence," explains Dr. Schiffman, from NCI's Division of Cancer Epidemiology and Genetics, and one of the world's foremost experts on cervical cancer and its cause, the human papillomavirus (HPV). "We only want to catch persistent infections."
The reason is simple: It's the persistent infections with 1 of approximately 15 "oncogenic" types of HPV that are responsible for virtually all cases of cervical cancer worldwide. In the vast majority of cases, however, HPV infections, and any associated cervical lesions, make only a cameo appearance before being suppressed or dispatched by the immune system. This is particularly true in women under 30, who are typically more sexually active and thus at higher risk than older women for new and multiple HPV infections (brief HPV infections are the most common sexually transmitted infections).
With this knowledge and the results of a number of studies over the past several years, experts on cervical cancer and HPV have begun to shift their thinking about the best way to weed out persistent infections via screening. The studies - including three published in October - have suggested that testing women 30 or older every few years for the presence of HPV using a DNA test may be a more clinically effective option than what has almost become a ritual for many American women, an annual Pap test.
But, when the time comes - and consensus is mounting that eventually it will - the switch, says Dr. Schiffman, will have to be done very carefully.
"We're not talking about abandoning a poor strategy for a good one," he says. "We're talking about moving from a very good strategy to an even better one."
Taking Advantage of Persistence
The persistence factor also lies at the root of the Pap's success. For any single test, the Pap is not particularly sensitive in detecting underlying, persistent HPV infection or precancer. But when performed annually, typically as part of a routine gynecologic check-up, the Pap test eventually catches most precancerous lesions before they become life threatening.
The need for such regular testing, however, has been criticized.
"Compensating for the poor sensitivity of cytology through frequent screening makes it difficult to assure that all women at risk are properly screened," wrote Dr. Thomas C. Wright of Columbia University in a recent commentary. Of the 10,000 cervical cancer diagnoses each year, he noted, half are in women who have not had a recent Pap test. The cost-effectiveness of such frequent testing also has been challenged.
Studies have consistently demonstrated that the HPV DNA test - of which only one is currently approved by the FDA - has a very high sensitivity, meaning a negative result provides great assurance that no dangerous infection is present.
But the concern with the HPV DNA test, which is more expensive than the Pap test, is exactly how to address positive results on a single test - results that usually represent a transient, and thus harmless, infection.
"It might mean a single HPV test doesn't refer to colposcopy," says Dr. Diane Solomon, from NCI's Division of Cancer Prevention, a co-author of a recently released risk-assessment guide for cervical cancer. During colposcopy, clinicians can more closely examine the cervix for lesions and, if necessary, take a biopsy. "Two positive HPV DNA tests a certain length of time apart might be required before triggering colposcopy. Such a strategy would capitalize on the increased sensitivity provided by HPV testing while targeting persistence."
The Interval Is the Thing
"It hasn't been published how long this 'protection' [from risk of a positive result] lasts," says Dr. Carolyn Runowicz, director of the Carole and Ray Neag Comprehensive Cancer Center in Connecticut and a gynecologic oncologist. "Can you go 3 years or 5 years? We need to work that out. We need to wait for the data from serial and longer follow-up periods."
The Kaiser Permanente's Northern California Region has spearheaded the movement toward longer screening intervals using HPV testing. In 2004, the region became the first health plan in the nation to offer - but not require - the HPV DNA test as front-line screening to all women 30 and older, but only in combination with the Pap test, which is consistent with its FDA-approved indication. It's also approved for use as a triage test after an "equivocal" Pap result.
Women who are negative on both tests do not undergo cervical cancer screening again for 3 years. A Pap-negative/HPV-positive result, on the other hand, elicits a recommendation for retesting 12 months later. If they get the same result, colposcopy is recommended.
Expanding the testing intervals for women who are negative on both screens has worked well, says Dr. Walter Kinney. "More than 90 percent of our members opt for both tests at 3-year intervals instead of annual Pap smears," he says.
It's too soon after initiating the dual-test approach to know if it has affected the Kaiser region's incidence rates. And Dr. Kinney and his colleagues have not reviewed the number of advanced cervical lesions detected using the combination approach since 2005. However, he says, they hope to receive approval from Kaiser's Institutional Review Board to do so next year.
"We have been very pleased with this approach," Dr. Kinney says, "and at no point have we contemplated moving away from it."
— Carmen Phillips
Treating Hereditary Thyroid Cancer in Children
Name of the Trial
Principal Investigators
Why This Trial Is Important
Surgery is the only curative therapy for patients with hereditary MTC. Patients whose tumors cannot be surgically removed (unresectable) or that recur following surgery need new treatment options.
In this trial, doctors are testing a new drug called vandetanib (Zactima) in young patients with advanced hereditary MTC. Vandetanib blocks the activity of the protein produced by the RET gene. Researchers believe that inhibiting the activity of the RET protein may cause tumors to shrink and reduce the levels of tumor biomarkers in patients with MTC. Besides looking for these treatment effects, doctors will assess the safety and the pharmacokinetics of vandetanib in these patients.
"MTC is the most common cause of death in patients with these genetic disorders, and the disease is relatively unresponsive to radiation therapy and standard or novel chemotherapeutic regimens," said Dr. Balis. "Vandetanib, unlike standard chemotherapy or radiation, specifically targets the genetic defect responsible for the development of these tumors."
Who Can Join This Trial
Study Site and Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Following are newly released NCI research funding opportunities:
Solicitation of Assays for High Throughput Screening in the Molecular Libraries Probe Production Centers Network
Letter of Intent Receipt Dates: Dec. 30, 2007; April 23, Aug. 26, and Dec. 23, 2008; April 22, Aug. 24, and Dec. 26, 2009; April 26, and Aug. 24, 2010.
This is a renewal of PAR-06-259 and PAR-06-545 and will use the X01 and R03 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3813. Inquiries: Dr. Ingrid Li - email@example.com; Dr. Christine Colvis - firstname.lastname@example.com
A Data Analysis and Coordination Center for the Human Microbiome Project
Letter of Intent Receipt Date: Jan. 15, 2008.
This funding opportunity will use the U01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3816. Inquiries: Dr. Vivien Bonazzi - firstname.lastname@example.com or email@example.com
Development of New Tools for Computational Analysis of Human Microbiome Project Data
Letter of Intent Receipt Date: Jan. 16, 2008.
This funding opportunity will use the R01 and R21 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3817. Inquiries: Dr. Vivien Bonazzi - firstname.lastname@example.com or email@example.com
Development of New Technologies Needed for Studying the Human Microbiome
Letter of Intent Receipt Date: Jan. 16, 2008.
This funding opportunity will use the R01 and R21 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3818. Inquiries: Dr. Jeffery A. Schloss - email@example.com
Thyroid in Aging
Application Receipt Dates: Non-AIDS Applications (new): Feb. 5, June 5, and Oct. 5, 2008; Feb. 5, June 5, and Oct. 5, 2009; Feb. 5, June 5, and Oct. 5, 2010.
This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3811. Inquiries: Dr. Nancy J. Emenaker - firstname.lastname@example.com
Thyroid in Aging
Application Receipt Dates: Non-AIDS Applications (new): Non-AIDS Applications (new): Feb. 16, June 16, and Oct. 16, 2008; Feb. 16, June 16, and Oct. 16, 2009; Feb. 16, June 16, and Oct. 16, 2010.
This funding opportunity will use the R03 and R21 award mechanisms. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3812. Inquiries: Dr. Nancy J. Emenaker - firstname.lastname@example.com
Human Microbiome Demonstration Projects
Letter of Intent Receipt Date: April 22, 2008.
This funding opportunity will use the UH2/UH3 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3814. Inquiries: Dr. Jane L. Peterson - email@example.com
Outcomes, Cost-Effectiveness, and the Decision Making Process to Use Complementary and Alternative Medicine
Application Receipt Dates: May 19, 2008; May 19, 2009; May 19, 2010.
This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3819. Inquiries: Dr. Wendy Nelson - firstname.lastname@example.com
NCI Issues Web-Based Resources for Tracking Cancer Trends
The CTPR is available online at http://progressreport.cancer.gov/. Questions about the report can be directed to firstname.lastname@example.com. The Colorectal Cancer Mortality Projections Web site can be viewed at http://cisnet.cancer.gov/projections/colorectal. Questions about the Web site can be directed to firstname.lastname@example.com.
Tumor Microenvironment Web Site Launched
NCI Cancer Bulletin Wins Award
The MarCom Awards is an international creative competition that recognizes outstanding achievement in marketing and communications. It is administered and judged by industry experts from the Association of Marketing and Communication Professionals. This year there were more than 5,000 entries from across the nation and several foreign countries.
The MarCom Award marks the second award received by the newsletter this year. In the summer, the Bulletin was recognized with a Gold Hermes Award for Communications.
If Memory Serves...
In the decade after the National Cancer Institute Act was passed in 1937, Public Health Service laws were rewritten to include more authority for research, grants, and training at NIH, as well as a clinical center. (Read more)
For more information about the birth of NCI, go to http://www.cancer.gov/
NCI Personnel Changes Announced
In the Division of Cancer Control and Population Sciences, there are four new branch chiefs. In the Behavioral Research Program, Dr. Cathy Backinger has been named chief of the Tobacco Control Research Branch, and Dr. Paige McDonald has been named chief of the Basic and Biobehavioral Research Branch. In the Epidemiology and Genetics Research Program, Dr. Mukesh Verma is the new chief of the Methods and Technologies Branch, and Dr. Britt Reid is the new chief of the Modifiable Risk Factors Branch.
Raising Breast Cancer Awareness in the Middle East
This October, I spent a week in the Middle East to promote breast cancer awareness and early detection. My travels took me to the United Arab Emirates (UAE), Saudi Arabia, Kuwait, and Jordan, where I met with government officials, leaders of medical and educational institutions, and prominent women's-rights activists.
The trip was an opportunity to bring the United States and the countries of the Middle East closer together by addressing the shared challenges facing women. Twenty-five years ago in the United States, breast cancer was a taboo subject. Because women didn't talk about the disease, they didn't benefit from early detection, which is the closest thing we have to a cure. Today, the situation facing women in the Middle East is similar. And through the U.S.-Middle East Partnership for Breast Cancer Awareness and Research, American women and Middle Eastern women are sharing their experiences and expertise to save the lives of women everywhere.
The U.S.-Middle East Partnership joins medical communities in Saudi Arabia, Jordan, and the UAE with the medical expertise of the University of Texas M.D. Anderson Cancer Center. This partnership will benefit from the educational resources of Susan G. Komen for the Cure and the commitment of the U.S. State Department.
Breast cancer is personal for me. Both my grandmother and my mother had breast cancer. Thankfully, they both survived their illnesses, and my mother is alive and healthy today because she detected her cancer early. Like many American women, she benefited from improved screening programs and increased public awareness. Today, 70 percent of breast cancer cases in the United States are diagnosed early, when they are much easier to treat. But in the Middle East, 70 percent of breast cancer cases are not detected until they reach stages 3 or 4.
In the Middle East, breast cancer comes with a heavy cultural stigma. Women are sometimes abandoned by their husbands when the disease is diagnosed. Such stories are discouraging, but on my trip, I was inspired by many more stories of hope. I met one woman whose husband and sons shaved their heads in solidarity with her while she underwent treatment. Other women who have been treated successfully are now involved in outreach and education campaigns to change the social norms in their communities.
In Abu Dhabi I visited the Pink Majlis, a forum for important discussions where breast cancer patients at Sheikh Khalifa Medical City are educated about the disease. And in Dubai, I helped launch the "Making It Our Business: Breast Cancer Awareness" program. Eleven companies, both American and Emirati, signed on as charter members, pledging to educate their employees, families, and customers about breast cancer.
In Riyadh, Saudi Arabia, I visited the Abdul-Latif Cancer Screening Center, which has just installed state-of-the-art facilities. And at the King Hussein Cancer Center in Amman, Jordan, I announced that the U.S.-Middle East Partnership will expand to Morocco, the Palestinian territories, and Egypt next year.
Through this historic partnership, these countries and medical institutions will share discoveries and data that can lead to world-class cancer research. New and better treatment options for breast cancer can come from a researcher in Washington, a biologist in Amman, or a young doctor in Riyadh. Wherever these options are discovered, they will help women in the Middle East, the United States, and countries around the world live long and healthy lives.


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Get up close and personal with big game in Tanzania's wildlife-packed National Parks or climb Africa's highest peak - snow-capped Mount Kilimanjaro. Laze on a white sand beach fringed with palm trees and dive and snorkel in the warm, turquoise Indian Ocean waters. Stop at a village to try mbege (home-brewed beer made with bananas). If you prefer urban exploration visit Dar es Salaam or the new capital, Dodoma. The magic of historic Zanzibar and the other spice islands' is just a short hop away.
Dominated by 19,335-foot Mount Kilimanjaro, Tanzania's mountainous north-east contrasts with a large plateau in the country's centre. To the west are dense forests and the vast lakes of Victoria, Tanganyika and Nyasa; to the east, the turquoise waters of the Indian Ocean. In the 1990s, Tanzania's National Assembly moved to central Dodoma, and declared it Tanzania's new capital. Bustling Dar es Salaam remains the commercial capital, and is still home to several government offices.
Start off in Dar es Salaam, the international gateway and commercial hub, or visit Dodoma in central Tanzania, the country's new capital. In the west, see the town of Kigoma, one of the busiest ports on vast Lake Tanganyika. Vibrant Mwanza is Tanzania's major city on Lake Victoria in the north-west. Going on safari? With a lively music scene, Arusha, in the north near the Kenyan border, is a good base. Along with Moshi, it's also a starting point for an ascent of Mount Kilimanjaro.
Watch lions stalk wildebeest on the plains of the Serengeti and photograph zebra and elephants in the Ngorongoro Crater. Chimpanzees are in the forests of Gombe Stream National Park, but you'll have to look hard to spot them. Feel proud and humble at the same time looking out over the endless plains after conquering the highest mountain in Africa, Mount Kilimanjaro. Seek out spices in their natural forms on Zanzibar, and after all that dive, snorkel or just laze under a coconut palm on a white sand beach.


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Elisa's Q & A
Who's your favorite sports team, and why?
I don't even know a name of a sports team.
What's your favorite movie quote?
Miss Piggy "I spy because I care!!!!"
What's your favorite video game, and could you kick our butts at it?
What's the most embarrassing song on your iPod?
I am not embarrassed of my love for Justin Bieber.
What's your best party trick?
I wear a chicken suit and start stripping it off slowly.
What's the worst job you've ever had?
I've never had a job.
It's 4AM after a crazy night out – what are we eating?
What's the strangest thing in your fridge right now?
Things that are green and growing in different forms.
What's the naughtiest thing you've ever done in public?
Stolen a car.
What do you feel sexiest wearing?
A dildo.
Tell us a joke.
That I think I can actually win this contest hahah lol


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I was at the Washtenaw County Courthouse in Ann Arbor on Thursday to hear some pretrial motions in connection with the dismissal case against disgraced Wayne County Circuit Court Judge Wade McCree.The hearing was kind of weird. The first thing you got to know is Judge McCree didn't even bother to show up. That surprised even the judge."I guess it should also be noted on the record that Mr. McCree is not here and evidentially he's not going to come," said Judge Charles A. Nelson. "He didn't have to be here. I just thought he'd have some interest."Now the second weird thing was Judge McCree seems to be taking a page out of Kwame Kilpatrick's book. His lawyer admitted that he was sleeping with a young woman that had a case before him, but those text messages can't be confirmed and, at best, they are irrelevant."They haven't authenticated these messages at all. These have nothing to do with anything other than some titillation over some, I hate to say it, 56-year-old guy who's carrying on a relationship with a very attractive apparently, I've never seen her, 30-year-old woman," said attorney Brian Einhorn."We are not dealing with an extramarital affair by just anyone. We are dealing with an extramarital affair by a judge, who had met his mistress during a court proceeding on a case that was pending before him, a case that he had exchanged text messages discussing, communicating, talking about the sentencing of the defendant in the case in which Ms. Mott was a complaining witness," said Margaret N. Rynier, attorney for the Judicial Tenure Commission.The judge ruled the text messages are admissible. Although he sealed them, we will be able to hear them come May 20 when the trial kicks off for real.
WTXF-TV330 Market StreetPhiladelphia, PA 19106-2796Phone: (215) 925-2929Fax: (215) 982-5494


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- SBI MLS Save of the Week: Bill Hamid
- Soccer Tuesday: Your Running Commentary
- Reports: NYC FC turns attention towards Queens after Bronx deal falls through
- CCL Preview: D.C. United and Portland face tough tests in quest to reach knockout round
- MLS Ticker: Red Bulls steer away from USL Pro team plans, Orlando City announces MLS roster moves, and more
- Road to the US Open Cup final: A Look Back
- UCL Preview: Liverpool makes return as group stage begins
Key Soccer Sites
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SBI Soccer Blog Roll
MLS Team blogs


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Even a fire hydrant is feeling the Blackhawks spirit, especially after Chicago's midnight victory over the Boston Bruins at the United Center in triple overtime.
FOX 32 News viewer Karen Karges sent in photos of a very festive Villa Park fire hydrant.
The village of Villa Park has a special program where residents can "adopt" hydrants. The benefits help the Villa Park Fire Department buy new equipment as they need to be replaced.
Karen's family "adopted" the fire hydrant on their block, and her daughter Michelle painted it as Tommy Hawk.
Michelle is a junior at Iowa State University, where she's working toward a degree in graphic design. Karen said her daughter loves to paint and decorate.
That's a unique way to show Hawks pride!
Follow @fox32news


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New Adobe mobile apps are here. So you can create anywhere.
Sketch is a drawing and sketching app for the iPad that gives designers a connected creative process, bringing inspiration, sketching, and community together in one place. Learn more
Adobe Line recreates the art of drafting for the iPad, combining organic drawing with beautiful straight lines and perfect shapes that can be drawn in plan and elevation views or in perspective. Learn more
Edit on the go with powerful Photoshop editing features, including Upright, Content-Aware Fill, and Camera Shake Reduction. Apply different looks to your images, make selections, create masks, and more. Refine your work in Photoshop CC. Learn more
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Edit and organize images on your iPad and iPhone. Seamlessly sync the changes to your desktop. Enhance everything from smartphone photos to raw images from DSLRs. Learn more
Capture and explore your design ideas on the go using vectors, layers, and color themes in the perfect tablet companion to Illustrator. Sync files to Creative Cloud to keep working on the desktop. Learn more
Find color inspiration anywhere. Make color themes using an iPhone or your favorite browser. Sync themes to Illustrator and apply those colors to your design immediately. Learn more


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iStockup is an exciting new website that offers professionally shot, royalty-free stock photographs and illustrations at no cost to you.
Everyone can benefit from our services; From web developers and graphic designers to video editors - for personal or commercial use. Our entire catalog of high quality photos and illustrations is there to help you get the job done.


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When framing your photos, look for natural lines that draw attention to your subject. In the photo below, Trestle at Twilight, you can see how the rails and tracks draw attention to the trestle in the distance.
Normally, I avoid power lines in my photos. However, in this photo, the power lines on the left also draw your attention down toward the trestle. The power lines also provide balance to the photo since there are trees and buildings on the right side of the tracks.
This photo was taken at a time photographers call, "the blue hour". The blue hour is the hour before sunrise and the hour after the sun sets. More on blue hour photography next week!
Greg Belfrage is an amateur photographer in Sioux Falls, SD. You can view more of his artwork at http://www.redbubble.com/people/dakotavistas or follow his photos on Facebook.


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EVERY SATURDAY & SUNDAY: High Line Field Station
EVERY SATURDAY & SUNDAY: High Line Field Station
Make the most of your visit and stop by the High Line Field Station to chat with High Line Greeters. These dedicated volunteers can answer your questions and provide information about the park's unique design, history, horticulture, art, and more.
Chelsea Market Passage
On the High Line at West 16th Street
The High Line Field Station is open every Thursday and Friday afternoon between 3:00 and 7:00 PM, and every Saturday and Sunday between 11:00 AM and 7:00 PM.
The High Line Greeter Program is generously supported by REI and, in part, by public funds from the New York City Department of Cultural Affairs in partnership with the City Council.


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Customer Reviews for Solar Screen Office 14% Openness Window Shades
"Great Look"
By Ike from Las Vegas
This was very easy to install if you read the simple directions. They look really nice and block enough sun to keep the heat out yet leave a sufficient amount of light to come through. I would recommend this to anyone.View this product
"super satisfied"
By the "can do most any from St. Paul, MN
We had existing solar screen roller shades from a different company and needed more. I think this other company prefers larger projects than our small office because they never called back with a quote. Finally I looked online for other options, found Blindsgalore, got some samples, placed my order, installed the shades. We couldn't be happier! They look great! Since they are in different rooms than the other roller shades, no one notices that they are not the same manufacturer. These were very easy to install. My only complaint... that I waited so long to look for other options.View this product


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Customer Data Management and Marketing Analytics
What would you do if you knew how your customers' social connections influenced their purchasing behavior?


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Spellsword Cheats for iPhone - iPodHome / iPhone - iPod /
This page contains Cheats for Spellsword organized by sections for iPhone - iPod. Spellsword is a Role-Playing General game, made by Everplay, released on Apr 26, 2012 and published by Everplay. If you can't find a hint or secret in our list, then please check this page periodically for the latest updates.
- Developer:
Spellsword iPhone - iPod CheatsEverplay
- Publisher: Everplay
- Genre: Role-Playing General
- Release Date: Apr 26, 2012
- ESRB: Not Set
Stuck on this game? Set a specific, clearly defined question and let others answer your question or view answers to previously asked questions. If you think you are an Spellsword expert then please try to help others with their questions.
After finishing the game and max out a couple of card I realize I was lvl 74 is there a point in the level up system?...
Posted on: 01-05-2013
Don't forget to Bookmark this page for the latest Spellsword Cheats. At this moment there are no cheats or walkthroughs available for Spellsword. If you know cheats, secrets, hints or glitches for this game then please Submit them.Submit Cheats
Otto Matic - Gameplay Review Trailer
- Sep 26, 2014, Views: 0
Cursed Treasure 2 - Gameplay Video
- Sep 26, 2014, Views: 0
Puzzle Warriors Adventure - Gameplay Video
- Sep 26, 2014, Views: 1
Angry Birds Transformers - Gameplay Video
- Sep 26, 2014, Views: 1
- Airheads Jump - Gameplay Video, (iPhone-iPod)
- SkyBound (2014) - Gameplay Video, (iPhone-iPod)
- Welcome To The Dungeon - Gameplay Review Trailer, (iPhone-iPod)
- School Driving 3D - Gameplay Review Trailer, (iPhone-iPod)
- Run Run 3D - Gameplay Review Trailer, (iPhone-iPod)
- Puzzle Guild: The Dragon War - Gameplay Video, (iPhone-iPod)
- Goat Simulator - Gameplay Video, (iPhone-iPod)
- Robot Rundown - Gameplay Review Trailer, (iPhone-iPod)
- A Big Vegas Party Casino - Top Slots And Gambling Games, (iPhone-iPod)
- Quad Math, (iPhone-iPod)
- Art Drawing With Creative, (iPhone-iPod)
- Absolute Las Vegas Casino Classic Slots, (iPhone-iPod)
- Zet Fighter Shooter Plane, (iPhone-iPod)
- Yin And Yang Swipe, (iPhone-iPod)
- World War II IO, (iPhone-iPod)
- Wild Life IO, (iPhone-iPod)
- Ultra Sonic Dash Mania - Jumpy Little Girl Rush, (iPhone-iPod)
- Toy Balls Tap: Impossible Fast Popper Smash, (iPhone-iPod)
- Kim Kardashian: Hollywood - Gameplay, (iPhone-iPod)
- Episode: Choose Your Story - Gameplay, (iPhone-iPod)
- How To Train Your Dragon 2 - Ready To Fly Trailer, (Wii)
- The Settlers - Kingdoms Of Anteria - Announcement Trailer, (PC)
- Entwined - Quick Look Trailer, (PS3)
- Blue Estate - Official Launch Trailer, (PS4)
- Goat Commando 3D Simulator - Gameplay, (iPhone-iPod)
- Munin - Official Launch Trailer, (iPad)


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That link isn't working either for me
Did you test again today?
I *think* I can see something on both tests from yesterday but I'm not positive. FX for you!
todays afternoon test... its darker than this am. This morning I used a first response and its still so light that the reflective cover makes it very hard to take photos! Hoping tomorrow is a visible difference! Last month I got my first clear + on 13dpo! Here is to hoping right!!!
*Definitely* seeing a line on that one, especially the invert...wooohooooo, looking good !!! I can't wait to see tomorrow's test...eek !
This was this morning's test... I use the dip method and think I may be over-dipping lol! I also tested in the middle of the night and was half asleep so I didn't "dip" as long and the result seems more readable to me... My obsession with POAS deffinitely overtakes me at some point... Kay you are a very strong woman to resist the urge but I deffinitely know why! I know my boring tests probably arent that fun for you guys to look at but hopefully tomorrow will be!
I saw a line on the invert with the dollar store test! Still no seeing anything on FRER Can't wait to see some darker lines!
Me too! Thanks for checking my test!
I can see it slightly on the frer invert if I zoom in...woot!!
I can see it on the dollar store test! Still having a hard time with FRER, which is weird. I can't wait to see tomorrow morning's test! I'm so excited for you!! Your tests are NOT boring! I love trying to line spot and watching the lines get darker!!!
Also, don't think I'm strong for not testing. I'm only not testing because I'm a complete baby and can't face a BFN. I envy those who can test so many times, see a neg, and keep going. I lay in bed for hours, and it's just not good for me.
I'll be stalking tomorrow morning!
Thanks kay! I'm looking forward to seeing your test when your ready!!!
This morning's test with fmu! I think its deffinitely getting darker but after my chemical last month, I am nervous that it is gonna happen again... Tomorrow is my beta though so hopefully I will have a brighter outlook then!
I see it!! fingers crossed for you cookie!
I see it!! Good luck tomorrow! I will be stalking!
Cait[24] & Gene-Paul[28] Dx with PCOS & Left Tube Blocked Dec. '12
Sean Patrick born 3/11/14, 7lbs 13oz
I see a pink line!!! Yay!!
I see it Cookie! Really hoping you get great numbers back tomorrow!!!!
Mel (39) DH (37) Finally, a baby boy after 12 months of TTC!
April 2013 http://www.saferpills.org/
Thanks ladies! I'm hoping for some darker lines tomorrow!
I've never wished weekends would go so fast until TTC lol
I see a line
Karen (28), DF (28), DD (3), DS (2 months)
Beanpop's Fluffy Butt Diapers *GRAND RE-OPENING 3/13*
I see something on that last one. Though at 13DPO I would expect a much darker line, are you sure of your 'O'? Good luck!!!
~*~Katrina~*~ Momma to Xander, Hayden & Lily (6) and Jericho (3 1/2)
I triggered two weeks ago tonight. I have done a few cycles of injections. The first cycle I had to cancel because I over stimulated and last month I had a chemical!
I had a stabbing pain in my uterus on 11dpo... Do you think that I implanted that day and now 2days later I would have a faint line? I'm slowly losing hope today.... If I don't have a darker test tomorrow I'm gonna feel like this cycle is lost!
Well they say an egg is only viable for 24 hours, then the travel and implant process can take 7-10 days. So if you triggered on the 7th, you would have likely ovulated 24-36 hours later...so you could have implanted the 17th-19th. Fingers crossed!
~*~Katrina~*~ Momma to Xander, Hayden & Lily (6) and Jericho (3 1/2)
I am becoming a nervous wreck... Hopefully I am pregnant and its hormones making me this crazy! I took this picture about two hours after the test this afternoon. It got darker after I looked at it but its still much darker, in my opinion, than the ones I took this morning with the same brand test! I need it to be tomorrow already!
I think todays tests looks much darker! I couldn't see it when I looked at yesterday's test but it looks really obvious today!!!! So I am VERY optimistic for you if that helps!!! But I totally understand the worry after having a loss. I hope this a your THB!!! I am sending you truckloads of sticky vibes!!!!
Thanks lizamay! That makes me feel better!


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What would you like us to do with the funds you've selected
This shows the number of portfolios you hold. Portfolios can be constructed from Unit Trusts & OEICs,IMA Unit Trusts & OEICs,Investment Trusts,Pension Funds,Life Funds,Offshore Funds,Exchange Traded Funds and cash. Holdings and acquisition costs can be recorded so that profits/losses can be calculated. These can be calculated in terms of a number of base currencies. Overall portfolio values, as well as portfolio constituents, can be made the subject of alerts.
You have one watchlist, and this shows you the number of items currently stored in the watchlist. Items stored here do not have holdings records, so this list simply monitors the price of items held, which can also be subject to alerts
Funds Basket:
This is designed to be a temporary collection of items selected by you for further analysis in the tools section. Items can be subsequently transferred from the Basket to the Watchlist or Portfolio.
If there is a yes vote in the upcoming Scottish referendum, will you look to move cash out of investments with exposure to Scotland?
The performance of offshore funds on FE Trustnet is set to default in their own native currency, however if you want
to compare the performance of funds which are denominated in more than one currency you may wish to rebase
performance into UK sterling – so you can see what these funds have really produced in returns after the effects
of currency fluctuations and exchange rates have been taken into account.
13:00 | Monday, January 20, 2014


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Widget and Gadgets Support
West Milford, NJ 07480
Welcome to the WeatherBug Frequently Asked Questions (FAQ) and product support page for the WeatherBug family of weather widgets and gadgets. If you have a product question or issue that is not addressed here, you may want to visit the WeatherBug Forum to search related topics for posted feedback and discussion threads from users and WeatherBug representatives. Otherwise, please fill out a Support Request Form.
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