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New FDA Guidance Aims to Speed Early Drug Development
Last week, the Food and Drug Administration (FDA) released two new guidance documents and a final rule intended to streamline the early clinical development of new drugs and biologics for cancer and other diseases. The documents represent strategic actions that are part of the agency's Critical Path Initiative. The Critical Path is a blueprint for updating the technologies and tools needed to optimize the process of discovery, development, and delivery of medical products. These specific guidances address major barriers in the early development of new interventions, including testing small quantities of new agents prior to undertaking full-scale clinical trials and evaluating new investigational agents in humans before demonstrating their manufacturability.
The joint NCI-FDA Interagency Oncology Task Force (IOTF), which was established in 2003 to enhance and accelerate the overall process of developing new cancer interventions, has focused extensively on these issues as part of its work to improve the overall cancer drug development process. Read more
NCI Advisors Explore Future Research Investment Strategies
Last week, NCI leadership held an important retreat with members of the institute's primary advisory panels. This was the 3rd annual NCI Joint Boards Retreat, and together we grappled with how NCI programs can continue their pioneering innovative trajectory, given the current fiscal limitations facing biomedical research.
As the discussion at the retreat illustrated, the ongoing budget constraints will require difficult but creative choices. The retreat also reinforced for me, however, the resolve of staff and the community to take the necessary steps to ensure continued progress against cancer by accelerating the pace of discovery, development, and delivery.
The President recently signed the appropriations bill that provides funding for the Department of Health and Human Services (HHS) for fiscal year 2006. The bill includes $4.842 billion for NCI. However, after a government-wide 1 percent reduction, as well as adjustments made for recisions, assessments, and mandatory increases, NCI starts FY 2006 with fewer dollars than FY 2005, an amount that was already lower than the previous year. Read more
New FDA Guidance Aims to Speed Early Drug Development
Last week, the Food and Drug Administration (FDA) released two new guidance documents and a final rule intended to streamline the early clinical development of new drugs and biologics for cancer and other diseases. The documents represent strategic actions that are part of the agency's Critical Path Initiative. The Critical Path is a blueprint for updating the technologies and tools needed to optimize the process of discovery, development, and delivery of medical products. These specific guidances address major barriers in the early development of new interventions, including testing small quantities of new agents prior to undertaking full-scale clinical trials and evaluating new investigational agents in humans before demonstrating their manufacturability.
The joint NCI-FDA Interagency Oncology Task Force (IOTF), which was established in 2003 to enhance and accelerate the overall process of developing new cancer interventions, has focused extensively on these issues as part of its work to improve the overall cancer drug development process.
Today, 9 out of 10 compounds developed in the laboratory fail in human studies. "One problem is that researchers conducting very early studies were required to follow the same manufacturing procedures as those companies that mass-produce products for broad scale distribution," said Dr. Janet Woodcock, FDA deputy commissioner for Operations.
In the first guidance document, Exploratory IND Studies, FDA offers recommendations about safety testing, manufacturing, and clinical approaches that can be used in very early studies, sometimes called exploratory, or phase 0, trials. This guidance will allow researchers to develop a better understanding of parameters such as drug distribution, pharmacokinetics, and target localization of new agents prior to undertaking large-scale trials. INDs - Approaches to Complying with CGMP During Phase I, and an accompanying rule, outlines an approach for compliance with good manufacturing practice (CGMP) requirements for the manufacture of small amounts of drug product for testing prior to undertaking large phase I studies. Requirements for full-scale phase I studies will not change.
"This new guidance will allow investigators to evaluate microdoses of investigational agents in small numbers of patients, which will provide the opportunity to apply new molecular technologies, and answer questions about pharmacokinetics and potential biomarkers of efficacy and toxicity," said Dr. Anna Barker, NCI deputy director for Strategic Scientific Initiatives. "A microdose is less than 1/100th of a typical drug dose that would have a pharmacologic effect. However, it is sufficient for use in areas such as advanced imaging to assess effect at the molecular level, such as whether it is readily metabolized or is hitting its intended molecular target."
Dr. Barker added that through its intramural program, NCI has set up a new unit to do these types of trials on promising candidate drugs with a goal of speeding up safer and more effective cancer interventions to patients.
"This guidance really makes it possible to do those kinds of studies very early on, so we can screen a wider variety of individual drugs in the pipeline to better understand those we should take forward," said Dr. James Doroshow, director of NCI Division of Cancer Treatment and Diagnosis.
Dr. Steven Rosenberg, chief of NCI's Surgery Branch, added, "This will have a major impact on the ability of scientists to evaluate whether their findings will be helpful to patients."
NCI Advisors Explore Future Research Investment Strategies
Last week, NCI leadership held an important retreat with members of the institute's primary advisory panels. This was the 3rd annual NCI Joint Boards Retreat, and together we grappled with how NCI programs can continue their pioneering innovative trajectory, given the current fiscal limitations facing biomedical research.
As the discussion at the retreat illustrated, the ongoing budget constraints will require difficult but creative choices. The retreat also reinforced for me, however, the resolve of staff and the community to take the necessary steps to ensure continued progress against cancer by accelerating the pace of discovery, development, and delivery.
The President recently signed the appropriations bill that provides funding for the Department of Health and Human Services (HHS) for fiscal year 2006. The bill includes $4.842 billion for NCI. However, after a government-wide 1 percent reduction, as well as adjustments made for recisions, assessments, and mandatory increases, NCI starts FY 2006 with fewer dollars than FY 2005, an amount that was already lower than the previous year.
The number of competing Research Project Grants (RPGs) awards for FY 2006 is expected to be approximately the same as last year, with an average cost equal to what it was in FY 2005. That said, paylines and grantee success rates will again decline.
We presented these tough fiscal realities at the retreat, which included the Board of Scientific Advisors, Board of Scientific Counselors, National Cancer Advisory Board, and the chairs of the President's Cancer Panel and the Director's Consumer Liaison Group. Acknowledging that declining budgets are likely for the near future, we sought the participants' guidance on a number of critical questions, and asked for their long-term perspectives on some of the most difficult issues facing NCI and the cancer research community.
We also had the opportunity to model alternative budget scenarios for FY 2007, assessing the inevitable trade-offs that occur at different target levels for RPGs, paylines, and individual program spending. We are being confronted with very difficult choices. So while many excellent initiatives will continue to be supported, others will have to be cut.
As expected, participants offered forthright suggestions for NCI to consider. For example, on the crucial issue of how to mitigate the impact of low RPG paylines, there was consensus on the need to protect and sustain new investigators applying for first-time R01 grants. They urged NCI to continue our practice of setting paylines for first-time grantees at levels above the average R01 grant.
One interesting idea is to require biomedical institutions to provide mentoring components as part of their new investigators' grant applications.
Most importantly, the advisors agreed to aid in a more in-depth analysis of strategies to ensure continued innovation in research, including how to better promote partnerships with industry and other outside groups, support training, and find new mechanisms to measure progress and evaluate programs.
I want to express the institute's deep thanks to these outstanding leaders for taking their valuable time to help ensure that NCI will continue to foster and advance the type of research that will improve and save lives. Because now more than ever, it is imperative that we continue to engage in careful planning, monitoring, and reporting of our efforts. Those relying on us to defeat this disease deserve no less.
Dr. Andrew C. von Eschenbach
A Multipronged Attack on the Cancer Cell
These remarkable survival skills are due in no small part to a family of proteins spurred to action by stress in the cellular environment. These so-called heat shock proteins (HSPs) serve as both molecular mechanics and bodyguards to other proteins. Stressed intracellular proteins that begin to misfold, for instance, are quickly repaired. Mutated proteins that otherwise would be shuttled away by the cell for degradation are somehow aided in carrying out their tasks as transcription factors, hormone receptors, and the like.
One HSP in particular, HSP90, has fascinated researchers because many of its "client" proteins - those that require HSP90's chaperoning skills in both normal and stress-laden environments - also are members of the most-wanted list of proteins that spur cancer development and growth, including mutant p53, Bcr-Abl, HER-2, HIF-1, and many others.
Therein lies HSP90's potentially immense therapeutic value, says Dr. Len Neckers, a senior principal investigator in NCI's Urologic Oncology Branch, who has been a leader in HSP90 research.
"By inhibiting HSP90, you avoid focusing on a specific step in cancer development, which, as we're beginning to see, tends to allow cancers to evade molecularly targeted attacks," he says. "By inhibiting HSP90, we're simultaneously attacking multiple signaling nodes of a cancer cell's survival network."
In 1993, Dr. Neckers and his NCI colleagues discovered that a common, off-patent antibiotic, geldanamycin, could inhibit HSP90's chaperoning function. It was the first such discovery, and it launched an onslaught of research at institutions across the country and the world to delve deeper into HSPs in terms of their functionality and anticancer potential.
Jump ahead more than a decade, and five phase I trials testing a geldanamycin derivative, 17-AAG, developed at NCI in collaboration with the pharmaceutical company Kosan Biosciences, have now been completed in the United States and the United Kingdom. None, Dr. Neckers says, was a "home run," but that's typical for phase I trials, which are principally intended to establish safety measures, such as the maximum dose at which clinical and/or biological activity can be detected without causing life-threatening toxicities.
However, in a phase I trial of 17-AAG conducted in the United Kingdom on patients with a variety of solid tumors, two patients with advanced melanoma had sustained periods of stable disease, one of which lasted for nearly 4 years, says the study's leader, Dr. Ian Judson of the Institute of Cancer Research.
More than 20 phase II trials of 17-AAG - alone, or in combination with chemotherapy or targeted agents - are under way. The trials cover a broad range of indications, including advanced breast cancer, prostate cancer, and an assortment of leukemias.
Dr. Jeff Moley from the Siteman Cancer Center of the Washington University School of Medicine is leading a phase II trial of 17-AAG to treat two different kinds of thyroid cancer, including medullary thyroid cancer (MTC). RET, the protein that fuels MTC, is yet another HSP90 client, and Dr. Moley's research has demonstrated that 17-AAG inhibits RET activity.
"There is no standard of care for MTC patients with distant metastases who are no longer taking up radioactive iodine," Dr. Moley says. With 17-AAG, he adds, "We are plowing new ground."
The drug is also being tested in patients with chronic myelogenous leukemia who have developed resistance to perhaps the most famous and effective targeted drug, imatinib (Gleevec).
As it turns out, says Dr. Luke Whitesell, a pediatric oncologist at the University of Arizona currently on leave at the Whitehead Institute for Biomedical Research in Massachusetts, imatinib-resistant leukemia cells "retain their sensitivity for geldanamycin and, if anything, become more sensitive to it."
Dr. Whitesell, who was part of Dr. Neckers' team that discovered geldanamycin's prowess for inhibiting HSP90, is focusing much of his research on HSP90's role in allowing cancer cells to evolve and develop resistance to a given treatment.
"Acquired resistance is a fundamental barrier to curing many cancers," he says. "Within tumors, you've got a genetically unstable and heterogeneous population of cells with tremendous selective pressures placed on them. Evolution to more malignant, drug-resistant phenotypes over time is an inevitable, but poorly understood consequence."
His theory is that HSP90 not only moderates the impact of potentially lethal mutations in cancer cells, but also can preserve those mutations that confer resistance.
"If you could control cancer cells' ability to evolve, it could make other treatments more effective," he argues. In fact, cell line and animal model studies of cervical and lung cancer have shown that 17-AAG can enhance the effectiveness of what would otherwise be suboptimal radiation therapy.
Work is already under way at NCI and several small biotechnology companies to develop next-generation HSP90 inhibitors. 17-DMAG, an agent developed at NCI in collaboration with Kosan, is now in phase I trials. At least six other companies/laboratories are working on their own novel HSP90 inhibitors.
By Carmen Phillips
Quality of Postmastectomy Radiation Therapy Affects Survival
The JNCI study, led by Val Gebski from the University of Sydney, Australia, divided 38 comparisons from 36 trials of radiation therapy into 3 categories: optimal radiation therapy, defined by modern treatment guidelines; inadequate or excessive radiation therapy; or incomplete tissue coverage.
Overall, the study found a statistically significant 2.9 percent absolute increase in 5-year survival for all patients receiving optimal radiation therapy. This increase in survival rose to 6.4 percent at 10 years after treatment. In contrast, no significant increase in survival was found in patients receiving inadequate or excessive radiation therapy, or incomplete tissue coverage.
An increase in non-breast cancer death was noticed in the groups receiving any category of radiation therapy, but for optimal therapy, this was overshadowed by the survival benefit. The investigators applied the data on survival after optimal radiation therapy to hypothetical patients with different risks of recurrence and death. They determined that a high-risk patient receiving optimal radiation therapy has an 11 percent absolute reduction in risk of death from any cause.
"Consequently," state the authors, "we recommend that postmastectomy radiation therapy be considered as part of standard care for all women at high risk."
More Data on Prostate Cancer Screening, But No Answers
Two randomized clinical trials now under way in the United States and in Europe are investigating whether screening men for signs of prostate cancer saves lives. Many experts believe that only these large trials can answer the question of whether men should be screened, but the results are not expected until around 2009.
In the meantime, a study published last week found no evidence that screening reduced mortality among men in New England. The case-control study involved 1,002 men and looked at 2 commonly used screening methods, the prostate-specific antigen (PSA) test and a rectal examination. According to findings in the January 9 Archives of Internal Medicine, PSA testing, with or without rectal examinations, did not prevent deaths from prostate cancer among the men.
The researchers, led by Dr. John Concato of the Veteran Affairs Connecticut Healthcare System, acknowledge that more research is needed on the subject, and they urge physicians to obtain informed verbal consent from patients who undergo screening.
"This is a well-done study, but it does not really answer the question" of whether screening saves lives, comments Dr. Howard Parnes of NCI's Division of Cancer Prevention. "Until the results of the randomized trials are known, men should be encouraged to discuss the potential risks and benefits of screening with their physicians."
An editorial accompanying the study agrees with this message and notes that the long-awaited results are "now not that far away." The NCI-sponsored Prostate, Lung, Colorectal and Ovarian Screening Trial and the European Randomized Study of Screening for Prostate Cancer trial should be completed "after the next summer Olympics in Beijing," says Dr. Michael Barry of Massachusetts General Hospital.
New Algorithm Proves Effective for Colorectal Cancer Screening
Screening for colorectal cancer can significantly reduce mortality, particularly because precancerous polyps and adenomas can lead to blood in the stool, which is normally detected by a guaiac fecal occult blood test (FOBT). A study published in the January 6 online edition of Lancet Oncology shows that a more discriminating, immunochemical version of FOBT can be used to better determine which patients should be examined further by colonoscopy.
During an observational screening study in Scotland for colorectal cancer in men and women aged 50 to 69, researchers used the immunochemical FOBT test to collect 2 samples from each of 795 patients, all of whom had previously tested positive with guaiac FOBT. Patients then had clinical colonoscopies, and any disease detected was correlated with the results of the immunochemical FOBT tests. Patients who tested positive on both immunochemical FOBT tests were 7.57 times more likely to have an invasive cancer than were those who had either one or no positive tests. They were also 1.48 times more likely to have large adenomatous polyps and 3.11 times more likely to have more than three polyps of any size.
Dr. Callum G. Fraser, of the Ninewells Hospital and Medical School in Dundee, Scotland, and colleagues recommend that this "reflex" two-tier approach be used to distinguish between patients who would and would not benefit from colonoscopy. By eliminating guaiac FOBT-positive patients who are not double-positive on the immunochemical FOBT test, the need for colonoscopies would be reduced by about 30 percent. As reported, "The implications for national screening programs are important in terms of reducing costs, inconvenience, and associated morbidity, without compromising the effectiveness of screening."
Meta-Analysis Suggests No Cancer Prevention Benefit from Statins
A new meta-analysis indicates that the cholesterol-lowering drugs known as statins have no effect on cancer risk. The analysis was published in the January 4 Journal of the American Medical Association.
To conduct the study, Dr. Krista M. Dale and colleagues from the University of Connecticut School of Pharmacy and Hartford Hospital identified 26 randomized clinical trials of statins for cardiovascular risk reduction that met specific criteria, including the collection of information on cancer diagnosis or cancer death on more than 100 participants with follow-up of at least 1 year.
Statins have a "neutral effect on cancer and cancer death risk," the authors concluded.
The study's conclusion contradicts several recent retrospective, case-control studies, including a study published last May by researchers from Michigan and Israel, which found that people who took a statin for at least 5 years had a significantly lower risk of developing colorectal cancer than those not taking the drug.
The meta-analysis, although well-conducted, is not the final word on statins and cancer prevention, says Dr. Ernie Hawk, director of the NCI Office of Centers, Training, and Resources.
"The prior data from animal models treated with statins, the mechanistic data on possible ways they would fight cancer, and the observational studies suggesting reductions in cancer risk still make the question interesting," he says. "We still lack data from well-conceived phase II clinical trials focused on cancer-related mechanisms. These trials would help either to support or refute statins' potential use for cancer prevention."
NCI is sponsoring two such trials - one in patients at risk for colorectal cancer and the other in patients at risk for melanoma. Both trials are expected to begin early this year.
New Databases Available for Calculating Racial/Ethnic Cancer Risks
New databases will soon be available from NCI that allow calculation of cancer risks among diverse racial/ethnic groups in the United States. Using these databases, with data centered on the 1990 decennial census, NCI researchers report that 48 percent of Japanese American men will develop cancer in their lifetime, the highest risk of the 10 groups studied. White men follow at 47 percent. Among men, American Indians are the least likely to develop cancer, at 24 percent lifetime risk.
Women in all groups, except for Native Alaskans, have a lower lifetime risk than their male counterparts, according to the research published in the December 30, 2005, online edition of Cancer. The authors calculated lifetime and age-conditional cancer risks of 10 racial and ethnic groups; previous estimates provided figures only for whites and blacks. More recent databases with racial/ethnic information are also available, but are limited to broader classifications because of the lack of detailed population estimates needed for the calculations.
The type of risk estimate reported by the authors measures the population burden of cancer because it integrates the chance of developing cancer with the chance of dying of other causes. For example, although black men have significantly higher age-adjusted prostate cancer incidence rates than whites, the lifetime risks of developing cancer in the two groups are more closely comparable because fewer blacks live to older ages when prostate cancer predominantly occurs. The authors conclude that this type of cancer burden estimate can complement routinely reported incidence and mortality statistics.
Breast Cancer Treatment for Premenopausal Women
Name of the Trial
Principal Investigators
Why Is This Trial Important?
In this trial, premenopausal women with endocrine-responsive breast cancer will receive the drug triptorelin to suppress the function of their ovaries (induction of menopause) and long-term antiestrogen therapy with either exemestane (an aromatase inhibitor), to inhibit the production of estrogen outside the ovaries, or tamoxifen, to block the growth-promoting effects of any estrogen that might be produced. Researchers hope to determine which antiestrogen treatment will help premenopausal women, whose ovarian function is being suppressed, survive longer without a recurrence of their cancer.
"We hope to see the same degree of benefit in this younger population that we currently observe in older, postmenopausal women on aromatase inhibitors," said Dr. Walley. "With this trial and others being conducted by breast cancer researchers, we hope also to determine the role of ovarian suppression in premenopausal women with early-stage breast cancer."
Who Can Join This Trial?
Where Is This Trial Taking Place?
Contact Information
An archive of "Featured Clinical Trial" columns is available at http://cancer.gov/clinicaltrials/ft-all-featured-trials.
Improving Diet and Physical Activity Assessment
Letter of Intent Receipt Dates: May 1, 2006; Jan. 1 and Sept. 1, 2007; May 1, 2008; Jan. 1, 2009.
Application Receipt Dates: June 1, 2006; Feb. 1 and Oct. 1, 2007; June 1, 2008; Feb. 1, 2009.
This is a renewal of PAR-03-009. This funding opportunity will use the R01 award mechanism. For more information, see http://cri.nci.nih.gov/4abst.cfm?initiativeparfa_id=3318. Inquiries: Dr. Amy Subar - firstname.lastname@example.com; Dr. Richard Troiano - email@example.com
NCI Holds Its 11th Annual Intramural Scientific Retreat
Highlights of the retreat included the invited award lectures for outstanding contributions in cancer research. Dr. Joan A. Steitz received the 5th annual NCI Rosalind E. Franklin Award for women scientists in cancer research for her seminal work on snRNPs, Dr. Elizabeth H. Blackburn received the 10th annual Alfred G. Knudson Award for her pioneering contributions in cancer genetics, and Dr. Steven A. Rosenberg received the 2nd annual Alan S. Rabson Award for excellence in NCI intramural research.
In addition, several scientists received the 2006 NCI Director's Intramural Innovation Awards, which are designed to support the development of highly innovative approaches and technologies aimed at significant cancer-related problems.
Applications Now Being Accepted for the NCI DCLG
ICRC Candidates Available for Interviews
OMH Conference Energizes Minority Health Leaders
One of the most overlooked aspects of Dr. Martin Luther King, Jr.'s, civil rights agenda was his call to action on health. He once said, "Of all forms of inequity, injustice in health is the most inhumane."
On January 9-11, to perpetuate Dr. King's legacy, HHS brought nearly 2,000 researchers; academicians; faith- and community-based health representatives; and state, local and federal government officials to the nation's capital for a national conference on eliminating health disparities. The 2006 National Leadership Summit on Eliminating Racial and Ethnic Disparities in Health marked the 20th anniversary of the Office of Minority Health (OMH), HHS's lead office on health disparities. NCI, which has identified addressing cancer health disparities as a priority, served as a cosponsor of the conference.
Attendees from around the country spent 3 days building and strengthening partnerships, exchanging ideas, sharing best practices, and advancing policies to improve the health of America's racial and ethnic minority communities.
The 2006 Summit also was an opportunity for broadening the health disparities agenda and discourse from the more traditional disease-focused approach to an issue-based approach.
The conference featured more than 96 workshops and special institutes on current and emerging health issues in the areas of health care access, utilization, and quality; health care and the public workforce; research, data, and evaluation; health information technology; health disparities across the lifespan; and culture, language, and health literacy. Specific issues that were examined included the quality of care provided to racial and ethnic minorities, patient/provider interactions and relationships, developing health technologies in minority communities, and workforce diversity.
The deliberations on these health issues will undoubtedly have far-reaching implications for health policies and programs targeting the elimination of health disparities.
Several NCI staff served as moderators for workshop sessions, and NCI Deputy Director Dr. Mark Clanton presented one of the prestigious Minority Health Community Leadership Awards on January 10 to two-time cancer survivor and African American businessman Robert Samuels, for his efforts to educate black men about prostate cancer as founder of the National Prostate Coalition. Mr. Samuels, who built a career in banking and finance, has survived both prostate and throat cancer.
Created by HHS in response to the landmark 1985 Report of the Secretary's Task Force on Black and Minority Health, OMH works to improve the health of racial and ethnic minority populations by advising on and coordinating HHS minority health promotions, research, policies, and programs to address health disparities. Since its establishment, OMH has collaborated with many HHS divisions; national, local, tribal, and other partner organizations; and individuals in myriad settings across the country.
To view the conference webcast, go to http://www.kaisernetwork.org/health_cast/hcast_index.cfm?display=detail&hc=1616.
More information on OMH can be found at http://www.omhrc.gov. For information on NCI's efforts to reduce cancer health disparities, go to http://crchd.nci.nih.gov.
Dr. Garth Graham


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Local law enforcement agencies aided neighboring departments Friday afternoon after four robbery suspects made a choice to run from the law.
"After receiving a call from Lincoln Parish Sheriffs Office, one of my units spotted the burglars at Exit 69," Bienville Parish Sheriff John Ballance said. "They gave chase until they were apprehended at exit 47."

subset: commoncrawl


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Dinner's done and the only thing more stuffed than the bird is you.
Now the question becomes: What to do with all those leftovers?
While many say simple reheating is all that's necessary to have a "day after" feast, others have elaborate recipes for turning Thanksgiving leftovers into gourmet delights.
From savory turkey soups to sinfully delicious pot pies and mile-high sandwiches, everyone has their own ideas on what to do with what's leftover. The Food Network even has an entire recipe collection dedicated to the topic.
We'd prefer to hear from you!
What are your favorite Thanksgiving leftover recipes? Share them in the comments box below.


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Gary Perlmuter is an attorney with the law firm Asker Perlmuter in Farmington Hills. He joins Fox 2's Murray Feldman in the Job Shop to discuss social media rights.
He provides the following article for the discussion:
The problem: One issue that is hot in the courts is which party owns the employer's Twitter account, the employer or the employee? This dispute arises when an employee creates a Twitter account for the employer and amasses lots of followers, and then the employee quits or is terminated and claims ownership of the Twitter account. Apparently, many employers have an employee create a Twitter account and let the employee handle the tweets. The employer has a strong interest in the Twitter account, but the employee controls it from his/her smart phone. Sometimes the account is even under the employee's name or a name that is not readily identifiable with the employer. These cases end up in court.
How to solve it: The business' Twitter account should be created by the employer/owner of the company and not by a non-owner employee. Further, the account should be controlled by the owner. If the owner gives the employee the duties or rights to maintain the Twitter account and to "tweet" for the employer, then such responsibilities and the limitations that come with it should be set forth in writing with the employee, preferable by an employer policy statement that the employee signs (or as part of the employment contract).
Further: the use of social media by employers to police employees is a hot issue. Employers should be very careful not to invade the privacy of their employees when utilizing social media to check up on employees and even discipline them. Employers should have written employment policies or handbooks addressing this issue and advising employees that they have no expectation of privacy in anything they post online, whether in a blog or in other social media. Further, these policies and handbooks should also advise employees that anything posted via company computer or smart phone is subject to review by the employer and that there is no privacy in anything posted through company devices.


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When he was told about a "surprise" at work, Cameron Pila was ecstatic. His first thought was that the new beds for the ICU (Intensive Care Unit) were being delivered. But to his surprise, he was recognized as the Employee of the Month for October. (And yes, the beds are being delivered this month, too.)
Always thinking of patients first, Cameron's passion for service, caring and excellence stands out in the ICU. His nominator described him as "very knowledgeable about his unit" and one of the "most dedicated employees."
"He sacrifices his own breaks to take care of patients and assist staff," the nominator said. "When my patient gives me a squeeze in the hand or a pat on the back as a sign of gratitude, it feels good," Cameron said. "My whole job is all about seeing a patient at the grocery store or at the beach looking healthy and happy."
Cameron started out in Kuakini as a part-time Certified Nurse Assistant (CNA) in the ICU and the Medical/Surgical department in 2006. He eventually moved to a fulltime position as a Healthcare Technician in the ICU in 2008. In addition to CNA duties such as bathing, cleaning, and fixing beds, he is responsible for setting up and preparing all instruments and supplies for bedside procedures such as arterial or chest tube insertion, or a tracheostomy (a procedure that creates a surgical airway in the trachea) or thoracentesis (a procedure that removes excess fluid from the space between the lungs and the chest wall). When needed, he serves as an assistant to the attending physician.
"In the ICU, doctors and nurses work together. There are no egos, our common denominator is patient care," he said. "Everybody works with everybody else. We are like family."
Cameron found himself at Kuakini after his father's physician, who was on Kuakini's medical staff, "ordered" him to become a CNA and apply at Kuakini, seeing that he took care of his dad very well. Cameron has not looked back since then.
"I'm on the path I'm supposed to take," he said, humbled and pleased at the recognition. "There are other employees that are more deserving, but I'm thankful."
Cameron plays golf at the Ala Wai Golf Course or Makalena Golf Course in Waipahu twice a month, and takes a walk three times a week to keep himself healthy.


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Availability: Usually Ships Within 24-48 Hours
Celsius Your Ultimate Fitness Partner Sparkling Orange 4 Pack (4 12-oz Cans)
Celsius is a great tasting drink that helps you get fit and stay fit. Multiple studies show Celsius consumed before moderate exercise will boost metabolism, burn calories, reduce body fat, provide lasting energy and improve endurance.
Get ready for your Ultimate Workout with Celsius! Celsius enhances the benefits of exercise - in the gym, on the court, or walking your dog. Celsius is powered by the unique MetaPlus formula containing good-for-you ingredients, such as Green Tea with EGCG, Ginger, Calcium, Chromium, B vitamins and Vitamin C, all of which work together to raise metabolism, resulting in a sustained calorie burn that keeps you energized through your workout and beyond.
Celsius is a healthier alternative and contains no sugar, no artificial preservatives, no high fructose corn syrup, no aspartame and it is very low in sodium and calories.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose treat, cure or prevent any
**Celsius alone does not produce weight loss in the absence of a healthy diet and moderate exercise. Whether you walk the dog or exercise at the gym make Celsius Your Ultimate Fitness Partner. Visit www.celsius.com to read the clinical studies that show the benefits of drinking Celsius.
Niacin (as Niacinamide)
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Hello Mary Alice Welcome to the OlderWomanGroup
Thank you for joining this awesome group of Rob supports. Please swing by the Welcome to All New Members - Introduce yourself here! which can be found here -> http://thetwilightsaga.com/group/robertpattinsonfanclub/forum/topics/welcome-to-all-new-members and don't forget we need your birthday, not interested in the year, day and month is fine :D
Then join us on the comment wall, there are some very fanatical members here myself included and are always willing to support Rob and talk about pretty much anything else.
Noodles, MelissaO, Caz, Martina, Della and JulieK
Robert Pattinson Fan Club
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A surveillance video shows a guy that appeared to be a handyman handling his business on a sunny Sunday making sure a security door was secure and locked up tight. However, the cops say he is the criminal.
"The locks were broken, and it looked like someone had broken in," said shop owner Clayton Carter. "Someone could've just came in and had a free for all."
A man was caught on camera allegedly stealing parts from a heavy duty roll down door at Can You Picture This T-Shirt shop in Detroit.
So they setup their own sting operation and lured the suspect to a different spot, a bogus job to bust him. He took the bait. Carter called Detroit police in because his crew wanted the cops to watch what was about to go down.
"The police took a report and said that's all they can do for right now," Carter said. "He said, well, I'm completely sorry guy. My boss told me to do it."
The suspect's boss at Pro Line Doors said that is a lie and admitted to us that his employee did steal from the store, but broke the law all by himself.
"Truth is that somebody did steal, the employee did steal, and we're making it right," said the owner of PRO Line Doors. "He's no longer with the company after this."
Detroit police came back to the shop, took a good look at the video, cuffed the suspect and then put him in the back of a cruiser.
"Finally, I feel like justice has been served," said Carter. "They came and arrested the guy and took him to jail for stealing my stuff."
WTTG FOX 5 & myfoxdc5151 Wisconsin Ave. NWWashington, DC 20016Main Number: (202) 244-5151Newsroom: (202) email@example.com


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Our Party
Just link up your etsy and/or family-friendly business on the first link provided, browse other businesses before you and after you. It's a great way to network with other business owners. For the giveaways, same thing. Just link up on the second link provided your giveaways and join the other giveaways that catch your eye. If you have a creative post and you want to increase your followers, the appropriate blog party for that is called Creative Bloggers' Party & Hop.
Link opens every Tuesday, 5:00 pm, PST and ends Saturday, 11:59 pm.
Here's the party button. Displaying the party button on your blog, while optional, is very much appreciated! For one, it will help you to remember to come back here next week. Secondly, we want to spread the word about businesses and giveaways so many can join in. Mentioning it on Twitter and Facebook will also make you totally awesome :)
Friends, network, buy if you must, join the giveaways, and have fun!
PS: I'm not a blog police but in the name of order and organization, you'll be my bloggy BFF if you link up in the appropriate links :D Please note that there are two links. Here's the link for your businesses. There's a second link below specifically for giveaways so how about linking up your giveaways in there? Besides, it's easier to find and join your giveaways if they're in the appropriate link. If you accidentally linked up in the wrong spot, don't fret. Just click the red x before your link to delete it, then link up in the correct spot.
To bring maximum exposure for your giveaways, I'm collaborating with Brynn from MommyDigger so please feel free to link up your giveaways, too, in her party every Wednesday.


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CLAWSON, Mich. (WJBK) -- Three Oakland County teenagers are charged with sexually assaulting a 15-year-old Clawson High School student.Police say the teens recorded the assaults with a cell phone camera and showed the acts to other students at the school. Investigators say one of the teens then tried to erase the video after showing others, but the Oakland County Sheriff's Department was able to retrieve the data. The Macomb Daily says students reported the incident to school officials Oct. 15, 2013, six days after police said the sexual assaults happened.
The suspects, Terry Watts, 18 of Pontiac, and two 17-year-olds, one from Clawson and one from Pontiac, were arrested Friday and charged with three counts of third-degree criminal sexual assault.
One of the suspects was released on bond. The two remaining suspects, including Watts, were being held on $50,000 bond. The pair appeared in court Tuesday where a judge refused to lower bond.All three are scheduled back in court on March 14.
KSAZ-TV & KUTP511 W. Adams St.Phoenix, AZ 85003Phone: (602) 257-1234Fax: (602) 262-0177


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Community of Character
Character, integrity, and responsible citizenship guide life in the Deerfield community. We live the goal of celebrating each student's unique perspective to foster an inclusive educational community. Deerfield's program emphasizes students' roles as leaders in the community and the world. Deerfield students draw strength from the school community and its promise to offer an extraordinary education to a remarkable group of students.
Academic Excellence
We offer small, discussion-based courses in a wide range of academic departments. Advanced research opportunities, Alternate Study electives, and 19 AP courses provide students with exceptional academic opportunity. Our faculty has designed a variety of interdepartmental courses, team-taught by two or more faculty members, to enable students to create new interdisciplinary skill sets. Off-campus study opportunities aim to broaden students' perspectives and deepen their sense of self in the modern world. Deerfield graduates are consistently accepted by highly selective liberal arts colleges. Our college acceptance record is an enviable one, but it's the student, with the assistance of our college advisors, who determines his or her own course.
Spirit and Tradition
The Academy's tradition is held in our sense of place. The historic village of Deerfield in the Connecticut River Valley offers a long and rich American heritage. At Deerfield, our time-honored traditions foster lifelong bonds founded on personal responsibility, citizenship, and compassion. Gatherings such as school meetings, cookies and cocoa, dorm feeds, and spirited rallies draw the Deerfield community together. Deerfield's sit-down meals in the Dining Hall are marked by lively conversation and good food.
Faculty Commitment
Deerfield teachers seek to know every child and use that knowledge to advise each student in how to contribute his or her best self to the community. At Deerfield, teaching extends beyond the classroom to the dining table, the co-curricular activity, and the dormitory. Whether on the playing field or on the stage, our teachers are seen as coaches, and our coaches are seen as teachers.
The Arts play a significant role in the life of the school, both through academic courses and co-curriculars. Deerfield's visual arts department offers courses in studio art, drawing, painting, photography, videography and architecture. Our performing arts department offers courses in acting, directing, music ensembles, choral ensembles, music theory and production, and dance. Theater productions, dance performances, music concerts, and art exhibitions help shape each student's cultural awareness and aesthetic sensitivity.
Student Life
Deerfield is dedicated to creating a warm and supportive environment for our students. Dorm life fosters a sense of community on campus. Dorm proctors, peer counselors, andpeer tutors offer classmates valuable support. Ninety-five percent of Deerfield students choose to stay on campus over the weekends to take part in student-led activities. Clubs and organizations play a major role in life at the Academy. Student hangouts such as the Greer, the Louis Café, and the dorm provide opportunities for students to strengthen friendships and foster community spirit.
Community Service
The Community Service Program is active on campus and in local communities. Students may elect service as a co-curricular activity, participate in weekend projects, or travel during school breaks to help communities in need. Round Square International provides students with the opportunity to extend their commitment to service beyond the school year and across the globe.
Deerfield has a long and proud tradition in athletics. We field over 65 interscholastic teams. Our on-campus athletic facilities include over 90 acres of athletic fields, and our nearby off-campus facilities include a state-of-the-art boathouse, a first-rate golf course, and a downhill skiing site. Athletics at Deerfield are as much about fostering sportsmanship and camaraderie as they are about honing athletic skill. Our intramural teams allow students of any athletic ability to experience being part of a team.


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Deputies say they found around two pounds of cocaine in a car after a driver refused to pull over and sparked a high-speed chase through Beaumont Thursday morning. The chase ended in Vidor after the driver jumped out of the car near Highway 12.
Jefferson County Sheriff's Deputy Rod Carroll spoke with 12News just after the chase ended. He said the Sheriff's Office tried to pull over a car around 9:40 a.m. near Walden Road in Beaumont after the driver committed a traffic violation. The driver refused to stop and a chase began.
The chase went eastbound as the driver headed the wrong way in the westbound service road. The driver eventually crossed over and got into the eastbound lanes of Interstate 10. The chase went through Beaumont and into Orange County.
The driver got onto the service road near Highway 12 in Vidor, tried to make a U-turn and the car smashed into a concrete pillar of the overpass. Deputies say the driver jumped out of the car and tried to flee on foot.
A passenger in the car broke his right thigh bone in the accident and immediately taken into custody.
The driver was quickly caught after a short foot chase and was also taken into custody.
Officers say they found just over 2 pounds of cocaine inside the car.
Carroll told 12News that the two men are brothers from Florida. They are both being treated for minor injuries at Christus Hospital Saint Elizabeth at this time. Their names will be released as soon as they are arraigned, and Carroll says they will be booked in the Jefferson County Jail as soon as they are released from the hospital.
Both face felony charges for drug possession and evading arrest.
Newsroom: (409) 838-1212
Front Desk: (409) 833-7512
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Police in Denmark are being taken to court after accidentally chasing each other around in unmarked cars. According to "The Copenhagen Post," the incident took place back in January. One of the officers mistook the other for a speeding civilian, and started chasing after him. The other felt he was being pursued out of harassment. The mix-up only came to an end when the chasing officer rammed the other's car, causing them both to hit a third vehicle. No injuries were reported, but the cops are now facing charges of seriously endangering traffic safety.
Story courtesy of Metrosource News


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Bright Futures — The fine-jewelry craze is at a fever pitch. Here's what to invest in now.
CIRCA featured in the June/July 2014 issue of Harper's Bazaar
It's an exciting moment for aficionados of fine jewelry. Business is booming, auction houses are smashing sales records, and museums and luxury brands are curating blockbuster exhibitions. (The Denver Art Museum gets into the act this fall with "Brilliant: Cartier in the 20th Century.") So it stands to reason that the secondary market is picking up steam. "Mid-century modern—that's where the real heat is," says Jeffrey Singer, a cofounder of Circa, a New York–based company that buys and sells previously owned jewelry internationally. "I call it the 'cool and groovy'…


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(RNN) – It takes some people most of their lives to achieve something noteworthy, but college basketball players can do it during a 40-minute span by the time they reach 22.
An entire month – or career – can come down to single moments, and the memories last for decades.
That's why people who weren't even born while those moments happened can vividly recall every second like they were sitting courtside.
In no particular order, some of the greatest championship games in the history of the NCAA tournament are relived.
There were so many great things about this game, the commercial highlights showing that last-second lob do it injustice.
With 4 minutes left in the game, CBS flashed this graphic: Frontline scoring in the second half – NC State 0, Houston 15. Lorenzo Charles - who stuffed in Dereck Whittenberg's last-second heave - picked a fine time to end the Wolfpack's slump in the paint.
The three previous shots NC State made were well into 3-point range – except the NCAA didn't officially adopt the 3-point shot until 1987, so they held the last possession tied at 52 instead of ahead by 3.
The Cougars had two chances to pick off bad passes before the ball got into Whittenberg's hands, and in any other game they would have.
The Wolfpack somehow beat a team with Akeem Olajuwon and Clyde Drexler.
Olajuwon and Drexler finally got their title together – 12 years later with the Houston Rockets, playing down the street from their alma mater.
You can't make this stuff up.
Not to pick on Houston, but if you believe in the opportunities for redemption that sports offer, this is a game you have to love.
Georgetown lost to North Carolina two years earlier. Everyone remembers Michael Jordan's game-winning shot in that 1982 title game, but not many people remember what happened next.
The Hoyas took over with 14 seconds left – the basketball equivalent of eternity. Fred Brown didn't have a soul standing around him and for some reason threw the ball right into the hands of UNC's James Worthy. Game over.
Two years later, Brown was the first person Georgetown coach John Thompson hugged and the first person to hoist the winner's trophy. Thompson also became the first black head coach to win an NCAA men's basketball championship.
Everybody remembers Duke's first championship (1991), but does anyone remember its first Final Four appearance? Things turned out better for Louisville that night.
Milt Wagner stroked a pair of clinching free throws like no one else was in the building, and freshman forward Pervis Ellison bullied the more heralded Jay Bilas and Mark Alarie.
If the NCAA Tournament means anything at all to you, this is a game you should tell your kids and grandkids about.
The first nationally televised final in tournament history showed the racially divided country Loyola's starting lineup featuring four black players. That broke the unwritten rule of putting no more than three black players on the floor at one time. It also preceded the more well-known Texas Western team that inspired the movie Glory Road.
Beyond the social statement, it was just plain good basketball. The Ramblers' starting five never left the floor.
Loyola only made it to one tournament final, but that's OK. They did enough that one game to last a lifetime.
It's difficult to finish on top, and it's even harder to beat every team on the way there.
Indiana was the last team to do that, going 32-0 and winning it all in 1976 under Bob Knight.
Knight told his team before the season their goal was not to win the conference or the NCAA Tournament. Their goal was to go undefeated.
If only everything could be that simple.
Game of inches? You can say that again. If he had just rolled his fingers a hair differently, Gordon Hayward might have supplanted Christian Laettner as the player with the greatest shot in tournament history.
But that missed shot didn't make the game any less great, probably one of the greatest in history.
"The Wizard of Westwood," John Wooden, went out the way all champions wish. He won his 10th and final championship, ending the greatest run in college basketball history.
You know you've done something great when your accomplishments aren't even up for argument.
This was Georgetown's game. They had gone to the title game three of the last four years, and this guy named Patrick Ewing was playing center. Done deal, right?
Not so much. The Wildcats were nearly perfect shooting in the last two minutes, and they overcame a mountain of talent – with a little help from their opponents' poor execution in the last two minutes.
You could argue that Georgetown gave this game away, or you could argue Villanova deserved it more.
But no one can argue it should always have a spot as one of the greatest title games in history.
Copyright 2013 Raycom News Network. All rights reserved.


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TEAMS: Oakland Raiders, Cleveland Browns, New York Giants, Arizona Cardinals, Philadelphia Eagles, New York Jets, Baltimore Ravens
The NFL is a brutal sports league. Not just in the sense that players being able to hit and tackle each other at will, and resulting to some horrific injuries. No, it's the most brutal league because of roster cuts too. Dreams are made on the days after the draft when undrafted free agents are snapped up. They are then crushed like a bug in August when teams start trimming their rosters down to the required 53. But it's not all undrafted free agents who get cut during this time. Many veterans are also shown the door for various reasons, usually injury related. The difference is that veterans usually have a better chance of being resigned by another team. This week marks the start of the major roster cuts. Teams have until 4pm ET on Tuesday to cut their rosters down to at least 75 players. Already, some big names have been released. KR/PR Josh Cribbs – Oakland Raiders Josh Cribbs is probably the biggest name released so far. Cribbs was once an elite kick return specialist for the Cleveland Browns But his knee injury never fully healed. As a result he's lost some of his speed. LB Aaron Curry – New York Giants Aaron Curry was the fourth overall pick in the 2009 draft. Dubbed the "safest pick in the draft" he failed to live up to his expectations making only 39 starts and notching 5.5 sacks in five years in the NFL. This is partly because he's not very good and partly because he has bad knees. K Dan Carpenter – Arizona Cardinals. Dan Carpenter was signed by the Arizona Cardinals last week. One practice and one preseason game later, he was shown the door. Carpenter was signed to give some competition to beleaguered kicker Jay Feely. The competition obviously didn't work out. S Kenny Phillips – Philadelphia Eagles Kenny Phillips is another player to suffer the curse of having knee issues. Phillips started 41 games for the New York Giants and was a Pro Bowl-caliber safety. RB Joe McKnight – New York Jets The New York Jets don't have a very stable running back corps but they clear;y felt that they could o without 2010 fourth round pick Joe McKnight. McKnight has disappointed since entering the league and has had questions about his commitment to football. Photo: Matthew Emmons / US PRESSWIRE TE Visanthe Shiancoe – Baltimore Ravens The Ravens have lost Dennis Pitta for the season. So it makes sense that they would add some depth to their tight end corps. That depth came in the shape of Visanthe Shiancoe. Shiancoe was signed a mere month ago. He has now been released. Follow us on Twitter! @DownAndDistance @Praetorian_SK The post Who are the biggest cuts so far? appeared first on DOWN & DISTANCE - Presented by Sports-Kings.
Oakland cuts ties with kick return specialist Josh Cribbs
The Oakland Raiders Release WR/KR Josh Cribbs
NFL News: Josh Cribbs cut by Raiders
Raiders cut Josh Cribbs
Raiders give up on Josh Cribbs
Raiders Release WR/KR Josh Cribbs
Report: Raiders release WR/KR Josh Cribbs
Raiders Cut Josh Cribbs
Raiders Down to 75: Murray and Hanson to IR, Burris to PUP
Raiders release KR specialist Cribbs
Scott Raab talks about Brandon Weeden, Mark Sanchez, Josh Cribbs and the Indians – WFNY Podcast – 2013-08-26
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Take a tour of our Auburn Hills, MI Hotel
Featured Special/Package
Michigan Renaissance Festival Package
Book your Michigan Renaissance Festival Package and receive two tickets to the festival and breakfast at our Auburn Hills, MI hotel!More info...
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Showing 1 - 3 of 3 Products
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Featuring Traffic FlowSignal Rejection (TFSR), the CR75 Laser Radar Detector by Whistler helps elimi...
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Catalog #: 55044645
The SWRA-36 provides additional detection from the rear when integrated with your PRO-3600.
Online prices and product selection may vary from our retail stores. All prices and offers are subject to change. Copyright RadioShack Corporation 2014. All rights reserved.


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without your permission.
We will send you an email with an invite soon.
I need a revamp Twitter Mac App.
Just started playing the iPhone version of Street Fighter X Tekken! #SFXTKi
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Moderators: Jenise, David M. Bueker, Robin Garr
Bruce Hayes wrote:But, have you ever noticed that a wine is slightly corked and decided to drink it anyway?
Paul Winalski wrote:At the Yakima Valley barrel tasting many years back, I encountered a winery employee who was one of those persons blessed (I can't really call it a curse, except perhaps in his job) with the total inability to sense TCA. He poured me a glass that was positively reeking of mouldy cardboard and stale water in a toilet. When I said, "Phew! This wine is badly corked," he said in perfect honesty that he didn't smell or taste anything wrong with it. I asked him to call over a co-worker, who took one sniff, let out an exclamation of disgust, took the bottle away, and replaced it with another one (perfectly OK), with profuse apologies to us.
Bill Spohn wrote:To my way of thinking, a corked wine, even a mildly corked one, either goes back to the store or into the stew pot to tenderise some cut of meat.
Bill Spohn wrote:To the original poster - many of Jackson Triggs wines are bottled under plastic cork - was this one a real cork?
Michael Pronay wrote:Graeme, I personally know someone who has a total inability to smell/taste TCA. It's Dorli Muhr, Austrian wife of Dirk van der Niepoort. Of course she realizes the difference when she tastes both samples alongside — the corked sample showing less fruit —, but she not able to identify a corked bottle right away.
Users browsing this forum: Google Adsense [Bot], Robin Garr and 7 guests


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The rescue operation successfully completed today on the mountain peak Tetnuldi (4852m) situated on the main ridge of the Caucasus, in the regions of Svaneti. Representatives of the emergency management department of the interior ministry were able to save the Russian alpinists trapped on the Tetnuldi.
The Christian Democratic Movement of Georgia commemorated the heroes fallen in the war for Georgia`s independence and lit candles in honor of the killed soldiers in teh village of Shindisi of Gori district today.
Representatives of the Public Service Hall of Georgia`s second largest city of Kutaisi joined the Week of Memory for the heroes fallen in the war for Georgia`s independence.
The chairman of the Georgian parliament visited today the Ergneti checkpoint in the outskirts of Tskhinvali at the fourth anniversary of the Georgia-Russia war which took place in August 2008.
Different positions in one studio
Analytical progarm covering top weekly events
Georgia President Mikheil Saakashvili and Defence Minister Dimitri Shashkini attended the funeral ceremony of Georgian soldier Gela Tigishvili fallen during the Russian aggression in 2008. The funeral was held in the village of Kodistskaro, Kaspi region.
Bondo Shalikyan was killed in Minsk, Belarus, local media report. With the crime boss, reportedly, the person accompanying him was also killed. Bondo Shalikyan before Georgia`s Rose Revolution in 2003 owned oil business and Kutaisi local TV-company in Imereti Region of Western Georgia.
Within the Memory Week for heroes fallen in war foe Georgia`s independence, representatives of the youth wing of the United National Movement gathered letters by schoolchildren and students and took them to the family of Georgian hero Leri Lagurashvili, who died in the August war in 2008.
National flags were lowered at the Tbilisi City Hall today at the fourth anniversary of the Georgia-Russia war, which took place in August 2008. The mayor commemorated the heroes killed in the war for Georgia`s independence.
© 1994-2014 Rustavi 2 Broadcasting Company


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About 1858 a water powered saw mill was set
up at the site of the recently publicized old rock
Mill at Millville. The town was probably named
after this mill. The owners were Esaih Edwards
and Ray Kent. This mill was operated by Hyrum
Hayball. Later in the late sixtys a lath and shingle
mill was added.
About 1870 a mill was set up in Millville
Canyon at a location known as the "Flat". It was an
overshot wheel mill powered from water stored in a
pond nearby. The owners and operators were Frank
Catwell, John Hunt (also known as John Cook), Thomas
and Richard Jessop and the Garr brothers. This mill
was later changed to a steam powered mill and moved
to a location three miles farther up the canyon
at what is known as the "Elboe". This about 1880.
Jake Jeppeson, known as the best horseman in
Cache Valley, pulled the boiler up to this site with a
six horse team. The timber depleted at this site,
the mill was moved out of the canyon about 1898.
John Jensen of Millville remembers this mill passing
in front of his home.


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Fall is headed our way! Along with hayrides, crisp air and S'MORES! That time of the year is just.... wonderful. Check out Oh Happy Day and find out how to make a fun S'mores Kit that even includes a DIY Toasting Fork. It's clever and easy to do.
Are you a big fan of S'mores? Head over to Pinterest and you will find every thing from S'mores pie, cupcakes and brownies.
Are you following the Queen on Pinterest? If you are not... you are missing out on everything that's frugal, clever and chic!
{Related Posts}
DIY: How to Make Anthropologie Knock Off Letters
DIY: How to Decoupage a KitchenAid Mixer
DIY: How to Make a Candy Necklace


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The woman accused of impersonating a police officer has been arrested and is currently being transported from the Tyler Police Department to the Smith County Jail.
Police say Jennifer Louise Cowser, who was reportedly impersonating a police officer committed the same crime twice in one week.
Sunday night, October 15, a man was robbed at a car wash off West Front Street in Tyler when a woman presented a false police badge and demanded to search his car. Monday, police said a similar thing had happened in downtown Tyler at D & N Grocery last week.
Police say she offered sex to all of the victims, and then claimed to be an officer when they took her up on her proposition. Cowser has an extensive criminal record. She is also accused in a case back in June where three Hispanic men reported the same type of incident that had happened to them.
She has been charged with two counts of impersonation, with bonds of $150,000 each, totaling $300,000.
Related stories:
Copyright 2012 KLTV. All rights reserved.
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text:
GE 45115 Wireless Door / Window Security Alarm (2 Pack)ITEM #59328Trigger an alarm when a door or window is opened. The Wireless Door / Window Security Alarm includes two sensors that can be attached to windows, doors, sheds, cabinets, gates, and much more.
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Dakota Alert WMA-3000 Wireless Motion AlertITEM #7312This weatherproof transmitter uses a passive infrared (PIR) beam to detect people or vehicles to a distance of up to 80 feet, then sends a radio signal back to the receiver, which can be placed in your home up to 600 feet away.
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I/O Linc - INSTEON 50810 Remote Chime Alert KitITEM #50810Enhances your INSTEON network by generating a chime to alert you that there is something happening in or around your home.
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Microsystems Development CHIME-1 iChime Customizable DoorbellITEM #5069ICThis iChime Doorbell replaces your current chime and gives you the choice of sounds to announce your visitors. Choose from the pre-programmed selections, record your own tune with the built-in microphone, download using iPod, CD Player, PC, or MP3.
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Dakota Alert DCPA-2500 Wireless Driveway Probe AlertITEM #73157The Dakota Alert DCPA-2500 Wireless Driveway Probe Alert is a driveway alarm kit that is used to detect vehicles only.
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Mace 80201 95dB Entrance AlertITEM #79918This magnetic door alarm emits a 95dB alarm when the door is opened, sounding the alarm for 45 seconds before resetting automatically.
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I/O Linc - INSTEON 70414 Indoor/Outdoor Photobeam Entry Alert KitITEM #70414Add access notification to your home using an invisible photobeam and an INSTEON I/O Linc to trigger lights or appliances when a visitor arrives at or enters your property.
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Interlogix TX-6010-01-1 Supervised Wireless Smoke AlarmITEM #79515Reliable, simple to use wireless smoke alarm features self-diagnostic functions. Automatic drift compensation reduces chance of niusance alarm.
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Stating At $110.00
Mini Split HVAC
Super Blowout
The 28-C Series is the tankless solution for the high-end Paloma House that luxuriates its owners in an abundance of hot water. There is a 28-C solution for the water needs of any and every home.Very simply, the 28-C is a hot water server that can be installed as a multi-unit system to give you twice, thrice, even four times the volume of hot water of a single 28-R Paloma... on up to a colossal system consisting of 20 Palomas acting in concert as a single system.The brains for this system reside in a special multi-unit digital controller.
Do you need the abundance offered by the 28-C Series? Perhaps, if...You are afraid that a single 28-R Paloma will not keep up with the simultaneous hot water demand during the daily shower-time rush... orYou need a solution for the holidays, when who knows how many showers will be called into action... orYou need a hot water solution that will keep up with the hot water wonderworld you are building into your new home... orYou simply want to take advantage of the fast-fill capability of your new whirlpool tub, at rates of 8 or 10 gallons per minute.
Click here to download the product manual.
Note: These units are designed to meet or exceed ANSI (American National Standards Institute) requirements and have been tested according to D.O.E. test procedures and meed or exceed the energy efficiency requirements of NAECA, ASHRAE standard 90, BOCA Code and all state energy efficiency performance criteria for energy consuming appliances.


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We offer two Open Sitting sessions weekly; the second is on Sunday mornings, 9 AM-Noon. Tuesday night sessions are more informal than Sundays and are recommended for beginners who may need meditation instruction. Come and enjoy the energy of a shared meditation session.
Shambhala Online Teleclasses
Intro Meditation Programs
Find a Meditation Centre
Quick View of Programs by Center


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We are committed to the success of active and former military members. Our mission is to provide the resources for you to reach your goals.
Gain a new skill or learn a new hobby with our non-credit classes! Get the details or find a class.
Connect with a career counselor, gain job-seeking skills, study the labor market, see what jobs are hot, and more here.


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Moderators: Jenise, David M. Bueker, Robin Garr
Cynthia Wenslow wrote:AB, there are plenty of good wines in NM. You just didn't pick one of them!
Robert J. wrote:When is the YT tasting? I would love to join in if I haven't missed it.
A.B. Drury wrote:Robert J. wrote:When is the YT tasting? I would love to join in if I haven't missed it.
Tomorrow evening-ish; be glad to have ya!
Randy R wrote:Robert J. wrote:A"Wow, that smells like the dust I sweep from under my bed" to "An earthy, complex wine exhibiting aromas of fungi, earth, decaying leaves on the seventh layer of forest floor, wet hay on a foggy morning in a dew-laden barnyard, and an ever-so-subtle hint of salted leather".
Well said, Robert! Except, you shouldn't salt your leather.
A.B. Drury wrote:Legs? Flabby? WOTM? I need a translator
Users browsing this forum: Google [Bot] and 4 guests


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Annie the eight-year-old miniature pinscher wasn't herself Tuesday morning barking and starring out the window of her Waterford home. Scratching at the door, her owners knew something was wrong, but what?
"She acted like she had to hurry up and get outside right away," said Sue Miller.
So Miller let her out and Annie headed over toward her next door neighbor's car. Their neighbor is 80 years old. He has a bad back and bad knee and walks with a cane. Miller didn't see or hear him out there, but evidently Annie did."She went over there behind the car," Sue explained. "She looked underneath and then she started barking like crazy."Miller grabbed her coat, called for her husband and went outside.Annie led Miller to her neighbor. He was on the side of the car. He had gone out to pick up his paper and slipped on the ice coming back to the house.
They helped him up and inside. He had hurt his knees, but is okay. He was taking a nap when we stopped by, but his wife gave Annie a treat for her good deed.
"She's the star," said Lois Marshall.
Her owners think so, too, just glad Annie was so observant and persistent. Fortunately, they were all in the right place at the right time to help a neighbor in need.
"He said, 'I just went out to get the newspaper,' and he said, 'It's really icy out here,'" Miller recounted. "He said, 'Thanks so much. I appreciate it,' and he said, 'Tell Annie thank you, too.'"
"She's like a little hero," she added.
KTBC FOX 7119 East 10th StreetAustin, TX 78701Phone: (512) 476-7777Fax: (512) 495-7001


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Hopefully you don't have a weak stomach! This is Cole's thumb, which got pinched in the "hinge-side" of our playhouse door. OUCH! I got a call from my wife at about 4pm and all I could hear was him SCREAMING in the background and my wife's trembling voice saying "I'm taking Cole to the ER..."
Something that makes every parent's heart skip instantly.
After he got to the ER he (and Mom) settled down, it turned out to be only a SMALL fracture and some pretty chewed-up skin, but overall he was okay. No cast or splint...just some ointment and band-aids. The swelling has gone down and he's back to normal now.
I told my wife: "...well, this will be the first of many trips here..." Although, as no mother would, she didn't want to hear any of that :) But with twin boys only 19 months...I'm sure we'll be back...hopefully not anytime soon!


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26 U.S. Code § 6316 - Payment by foreign currency
Source(Aug. 16, 1954, ch. 736, 68A Stat. 778; Pub. L. 94–455, title XIX, § 1906(b)(13)(A),Oct. 4, 1976, 90 Stat. 1834.)
1976—Pub. L. 94–455struck out "or his delegate" after "Secretary" in two places.
The table below lists the classification updates, since Jan. 3, 2012, for this section. Updates to a broader range of sections may be found at the update page for containing chapter, title, etc.
The most recent Classification Table update that we have noticed was Tuesday, August 13, 2013
An empty table indicates that we see no relevant changes listed in the classification tables. If you suspect that our system may be missing something, please double-check with the Office of the Law Revision Counsel.
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Product Description
Total Hydration Drink for Dogs! K9 Go DOG, canine hydration drink is more than just water and carbs and it's not a human sports drink reconfigured for dogs. Its designed specifically for the canine metabolism and features a proprietary blend of electrolytes, short-burst and long-range energy fuels, plus vital buffering agents. These buffers help neutralize performance-robbing, potentially-lethal metabolic acid (H+) buildup.
The explosive muscular power that propels your dog into the air after a Frisbee or over an agility obstacle comes at a cost, heat. The more power generated, the more heat produced. This heat builds up and limits performance. In some instances it can even kill. There's never been much you could do but surrender to the endothermic (heat generating) effect. Except wait it out, hope for the best. Now that human sports drinks have proved themselves, we believe it's time that dogs benefit. That's why we developed K9 Go Dog.
Nothing does more to keep your dog in the performance and safety zone than Go DOG. Dogs operate within a narrow core temperature range. Their power zone is 100 - 104°F. Your dog's performance declines above this range and heat stroke becomes a real danger. Use K9 Go DOG, and see the longer-stronger-happier-healthier difference it makes in your dog!
Feed Your Head! Download Your Free 32 Page Booklet 'The Complete Guide to K9 Sports Drinks'. This is a MUST read for anyone with a competition, working or active dog.
Animal Naturals K9 GoDog provides the following powerful benefits:
• Promotes Rehydration & Recovery
• Aids Oxygen Transport
• Any Dog in Warm Weather
• Safety & Fun
• Helps Endurance
• Helps Build Stamina
• Helps Reduce Muscle Soreness
• Increase Oxygen Delivery
• Hydration
• Lactic Acid Buffering
• Exercise Comfort
• Mental Focus
• Trans Fat Free!
• K9 Athletes: Agility, Shows, Fly Ball, Hunting, Herding, IPO, Coursing & More
• Available in Single Serving Pouches and 1.25lb size
• Also in Combo Packs to Save You Even More!
K9 Go DOG strengthens all metabolic links to total peak performance.
• Improve Physical Performance - K9 Go Dog Increases energy production in slow and fast twitch muscle fibers; maintain higher output longer. Rapid & slow release fuels generate higher muscle ATP, boosting strength and power. Enhanced lactic acid & ammonia clearance reduces fatigue & the burn, extending endurance. Finally, enhanced oxygen delivery increases air (more V02 max remaining) & raises anaerobic threshold.
• Improve Mental Performance - K9 Go Dog raises oxygen and glucose delivery to the brain, plus neurotransmitter & hydration support, maintains mental focus even under the most grueling conditions.
Technical Information
Container Size: 1¼ lbs
Serving Size: 20g -1 scoop
Servings Per Container: 28
Guaranteed Analysis:
Protein 6%
Fat 9%
Carbohydrates 75%
Moisture 7%
Ash 3%
NO! sucrose, fructose, trans fat, corn syrup or by products.
K9 GoDog Human Grade Ingredients: GoDog Performance Factors™ Glucose polymers (long chain complex carbohydrates), Resistant starch, Mediumchain triglycerides, Protein-free tallow, Potassium L-lactate, Sodium L-lactate, O2Boost™ (L-Citrulline, L-Citrulline Malate, D-Ribose, Potassium ascorbate), Magnesium orotate, GoDog Recovery Factors™ Cooked chicken, L-Glutamine, L-Leucine,L-Valine, L-Isoleucine, L-Taurine, L-Carnosine, ALA (alpha lipoic acid), L-Alanine, L-Glycine, Phosphatidylserine, GoDog HydrationFactors™ USP Glycerol, Sodium citrate, Potassium citrate, Potassium succinate, GoDog Antioxidant Factors™ Vitamin E(alpha-tocopherol), Calcium ascorbate (non-acidic source of vitamin C), GoDog Joint Factors™ TMG (trimethylglycine),Chondroitin sulfate, MSM (S-Adenosyl Methionine), Sodium hylauronate (glucuronic acid N-acetyl glucosamine), Cholinebitartrate, Calcium Lactate, Pyridoxine HCL, Inositol, Dicalcium phosphate, Zinc L-Aspartate, Folic acid, ManganeseL-Aspartate, Thiamin monohydrate, Cyanocobalamin (B12), PABA.
Feeding Directions: Pour recommended number of scoops into a standard 21 oz. water bottle almost filled with clean water. Shake and start improving your dog's performance, fun and safety!
Before Exercise - Feed 25% of bottle 15 minutes prior to exerciseDuring Exercise - Take short break every 15–45 minutes – feed 25% of bottle at each breakAfter Exercise - Feed remainder within 30 minutes after workout
Dog shows and prolonged events - Keep energy and focus at peak during traveling, before, during, and after long shows. Feed 25%-50% of bottle every 30-60 minutes.
Important to keep in mind...Goal is to maintain GoDog's energy, hydration and oxygen boosting nutrients at effective levels throughout activity period. This is accomplished by feedings at regular intervals. Modification of the above recommendations is appropriate as long as the goal of regular intake is met.
After exercise, throw away unused portion. Do not retain. Thoroughly wash and disinfect water bottle. Using dishwasher is strongly advised. Always keep clean, fresh water available.


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Learn to speak another language while traveling! Our language classes in India will teach you the skills you need to learn another language. Learning another language abroad at our language courses is a great experience. Our language institutes make it easy to learn another language because you are completely consumed by new culture everywhere you go. You can take what you learned at our language centers to the streets and practice in public while doing every day tasks. Our language lessons in India will teach you a valuable skill that will enhance your professional and social life. Learning a new language is fun if you do it while traveling at our language programs. Browse our language schools in India and plan your study abroad trip today!
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Language Schools Amritsar, India - This institute offers foreign languages like French, German, Italian, Spanish, Russian, Dutch, Norwegian, Portuguese, English, Chinese, Japanese etc. Ajanta Foreign Language books through the medium of Hindi-English are available
Language Schools Amritsar, India - Services offered : * Best coaching for IELTS * Spoken English * Study Abroad * TOEFL * IELTS Teacher Training Course * Computer Courses * Personality Development Course
Language Schools India, India - Learn International Languages with Linguaphone Language Laboratory at your own pace place and time by following Linguaphone proven methodology of Listen, Understand and Speak.
Summer Camps & Programs Mussoorie, India - Himalayan Adventure Institute India's foremost outdoor education center, setup in beautiful Himalayan surroundings offering people of all ages and walks of life a feast of adventures. With some of the most talented and professional staff
Volunteer Vacations Pondicherry, India - Almond Shades is a Serene Villa situated 9 Km from Pondichery. It is situated away from the hectic noise and air pollution of the City .It provides a peaceful atmosphere with dense trees,Coconut groove,greenery & a swimming pool .
Photography Tours & Workshops North, India - If you are a photographer and want to improve your photography skills, or a foodie fascinated with street food and exotic places, this tour is for you. Tag along with Street Food of India author-photographer, Sephi Bergerson, on a tour of India
Summer Camps & Programs Mumbai, India - Embarking on a School trip is a great learning adventure for many students and educators have a heavy responsibility to ensure that the trip is well planned and the learning opportunities optimised.
Cooking Schools Kochi, India - conducts Traditional Kerala Indian Cookery classes for visiting guests, food writers, chefs and others involved with culinary
Summer Camps & Programs Bangalore, India - Evolve's Fun Personality Development summer camp in various locations: Locations: Girinagar, Banashankari, basvangudi, JP Nagar, Jaynagar, Kanakapura Main road, Seshadripuram Dear Friends The best gift you can give a child is a great futu
Summer Camps & Programs Bangalore, India - Young Champions summer camp in Bangalore is for Teens who want to develop Leadership & Entrepreneurial skills. It's aim is to make a difference by providing training programs which develops leadership skills to make your teenage kid a True Champion.


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7^/ iC^Ack^Jx,
—i— i
A brief history of the Town from pioneer days
until the time of 1912.
Before these fields were shorn and till'd
Full to the brim our rivers flowed,
The melody of waters filled
The fresh and boundless wood;
And torrents dashed and rivulets played
And fountains spouted in the shade.
--Byron --
Situated in the heart of the beautiful Cache Valley
surrounded on all sides by majestic mountains, stands in all its
beauty, the enterprising and growing City of Smithfield. A living
throbbing monument to the brave men and women of fifty years ago,
who toiled and labored in the face of seemingly insurmountable
barriers to build for themselves and future off-spring a place to
be called home. And proud, indeed, may the remainder of those
gallant pioneers who still survive, be, when they walk the streets
of this hustling little city and gaze upon the great results of
their labors of by-gone days.
From a desolate wilderness a trackless desert, the hauntof
the red men and wild beast, has srisen, through the indefatagable
energy and perseverance of the white man, a valley beautiful,
yeilding an abundance of good things in the way of luscious fruits
and rich, plentiful crops, and dotted here and there with thriving
growing towns.
It was in the year 1859 that there came to the banks of
Summit Creek, a beautiful stream of clear mountain water, shaded
by large cottonwood trees, a band of brave pioneers, who had
faced privation and the dangers of the desert, and chose thie
beautiful spot as a goodly place to settle. This party of home-


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Travel Set Cookie Gift Set
Cell phone, lipstick, handbag, heels and sunglasses - life's essentials in sweet sugar cookies. This gift set is perfect for traveling, without all the hassle!
Cookie Count: 6 hand-iced sugar cookies
Box Size: Single Layer Small Gift Box (5.75"x5.75")
Here at Eleni's New York, our custom Travel Set Sugar Cookies are delicious, adorable, Nut Free and Kosher! These decorative hand-iced cookies are gift packaged in our signature brown and pink Eleni's gift box, making it the perfect gift for any occasion.


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My video game playing days go back to the original NES console. Way back when I figured out what happened when you stayed in all day in hopes of conquering Super Mario Brothers. Never did figure out. (thank you Game Genie!) But I got the sore thumbs and pale skin from sitting cross-legged in front of my dad's old Sears brand 19" TV in the basement.
By David Arango from Oviedo, Spain (NES) [CC-BY-2.0 (http://creativecommons.org/licenses/by/2.0)], via Wikimedia Commons
Now that I have kids I'm immersed in video games again! I wonder if my son will want this console? I'm excited--analog connections, top loader... yup, very excited


text:
By Fox Broadcasting Company [Public domain], via Wikimedia Commons
Gillian Anderson, Agent Dana Scully, and David Duchovny, Agent Fox Mulder, are open to reprising their roles as FBI agents chasing alien conspiracies to government cover ups, in a third X Files movie. Now it's just a matter of getting the studio behind it.
I was a huge The X-Files fan back in the 90s and early 2000s. I watched both movies and enjoyed them even though the first was significantly better than the second. I am the person who is excited to see a 3rd movie, however, so many people were let down by the 2nd that I'm not sure it would be a box office hit.
What are your thoughts on an X-Files 3 movie?


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1940 1
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1940 Bonneville Dam - As construction at Hoover Dam drew to a close, the focus of dam-building activities shifted to the Columbia River, 40 miles east of Portland, Oregon. Here Bonneville Dam was built for the Army Corps of Engineers by Columbia Construction Company, The powerhouse was built by another association of contractors. Though by no means equal to Hoover in magnitude, Bonneville posed many problems, At the dam site the river is divided into two channels -- the north, or main channel, where the dam was built, and the south channel, which now contains the powerhouse. The broad river, equal in volume to the Colorado at flood, was 60 feet deep, with velocities up to 12 feet a second. Floods swept through the Columbian Valley in the spring and early summer months as melting snow in the hinterlands swelled the river out of its banks. The stream was so swift and deep that some had doubts that dam foundations could be anchored safely. Taming the river to dewater the dam site required an unparalleled coffer- damming operation. The river was diverted by sinking wooden cribs to the bottom, and filling them with river silt by Clamshells mounted on barges. The cribs were then firmly anchored and sealed by sheet piling and the area unwatered with pumps. As the river bed was dried in sections, 6,000,000 cubic yards of earth and rock were removed to make way for the foundations. One of the chief functions of Bonneville is to maintain the desired level of water upstream for the powerhouse supply. Eighteen spillway gates are used to adjust the water level as required, to allow excess water to pass. In addition to diverting water for power production, the dam maintains a steady water level for navigation. Its power plant became the central con- trol point for distribution of electricity generated by all Federal Government plants forming the so-called northwest power pool. Bonneville, a slab-and-butress structure, 197 feet high and 1,450 feet long, was built by Columbia Construction Company, which was a joint venture group composed of Henry J. Kaiser Company (sponsor), Kaiser Company, MacDonald & Kahn, Inc., W. A. Bechtel Company, Morrison-Knudsen and Utah. The approximate cost of the project was $17,000,000. Broadwater-Missouri Dam - Located near the city of Toston on the Missouri River in Montana, this project was completed in 1940. It is a gravity type structure with a height of 40 feet and a crest length of 705 feet. The volume content of the dam is 14,047 cubic yards. The capacity of the reservoir is 42, 000 acre -feet. The purpose of the dam is irrigation. The owner of this project is the Montana Water Company and it was engineered by them also. Approximate cost of this project was $692,000.
Object Description
|Stewart Library, Weber State University
|Earl R. Lubbers
|This is a five volume set documenting the history of Utah Construction Company from 1900 to 1964. It is a yearly account of the projects completed, bids won, and bids lost. Many times this contains the only record of some small projects.
|Date Original
|1962; 1963; 1964
|Physical Description
|5 Volumes Bound 8 1/2 x 11 in.
Utah Construction Company--History
Construction contracts
Construction projects--Management
|Digital Format
|Publisher Digital
|Stewart Library, Weber State University
|Date Digital
|MS 100 Box 50
|Conversion Specifications
|Archived TIFF images were scanned at 400 dpi with an Epson Expression 10000XL scanner and a Brother MFC-8860DN. JPG and PDF files were then created for general use.
|Digital Identifier
|Rights Management
|Materials may be used for non-profit and educational purposes; please credit Special Collections Department, Stewart Library, Weber State University.
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For the perfect way to celebrate anniversaries big or small, you can count on Helzberg Diamonds' anniversary rings to add extra sparkle to your special day. From stunning complementary pieces to showstopping diamond anniversary rings, you'll find the right one to surprise your favorite gal. Our gorgeous collection of anniversary rings includes a variety of breathtaking cuts to suit any taste.
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