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Top Apps
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Showing page 9 of 15.
DSP Emulator Test
This project contains some test scripts and software for Analog Devices' DSP chip emulators. This verifies whether a particular emulator is working correctly with a particular PC and target board.0 weekly downloads
Система управления для операторов связи0 weekly downloads
odf-converter-integrator is an easy way to open Microsoft Office 2007 files (also called Office Open XML, .docx, .xlsx, and .pptx) with a high-quality conversion on any Linux or Windows system in any OpenOffice.org.7 weekly downloads
Shared memory arrays for NumPy
Shared memory arrays for multiprocessing with NumPy. import numpy import sharedmem as shm arr = shm.empty(...) arr = shm.zeros(...) arr = shm.ones(...)0 weekly downloads
Cloud Target is a front-end to the python scripts that google uses to create, run and upload projects to its App Server system. This .NET application is based on the OSX front-end provided by Google in the SDK.1 weekly downloads
Icy Inuits
Help Icy the inuit find his lost fish and escape from the furry clutches of the evil polar bear in this small but addictive Python game.1 weekly downloads
CloverSnake - the imageboard /b/rowser
CloverSnake aims to become the browser of choise for users of imageboards. Initially, the browser will be available for Windows XP, and it will work with 4chan's random board; /b/. Ports to other OSes will be made later. Contact: email@example.com weekly downloads
Ball Game
My CS1P free programming project. A simple 2D ball game. Written in Python 2.x1 weekly downloads
katamotz lectura
Programa libre educativo para el tratamiento de la disléxia. Se trata de una herramienta de texto que hace aparecer o desaparecer el texto a la velocidad determinada. El texto también marca ciertas letras para que sean diferenciadas por el disléxi1 weekly downloads
Skyscraper: a small suite of ultilities for dealing with hand histories & account information on skypoker. Amongst them: download your old hhs & convert them to a readable form, graph your tournament perfomance, and even collect hhs whilst you play.1 weekly downloads
HGE Live!
2D game engine based on HGE and suitable for creating small shareware games. Main features: UNICODE, Physics, World Editor, Sripting.0 weekly downloads
ORE Reports
ORE Reports is a tool designed to make mining in the MMORPG 'EVE Online' more efficient through the useful manipulation of Data pulled from the game.0 weekly downloads
Firefix is a small tool written in python that solves the firefox audio issue I detailed here: http://zarindenatrose.wordpress.com/2008/07/31/fixing-sound-firefox-vista/1 weekly downloads
nJES is a complete CPython rewrite of JES (Jython Environment for Students), originally written by Mark Guzdial and Barbara Ericson. The primary objective of the rewrite is to enhance performance while maintaining full forward compatibility with JES.1 weekly downloads
SERVIA - это система распределенных вычислений и анализа данных, предназначенная специально для академических целей.0 weekly downloads
NRClientX is a GUI frontend to make NeoRouter client CLI easy to use on Mac, Linux and Windows. It provides the computer list, add-on commands and more.3 weekly downloads
Cake Build System
Cake is a build system that combines the flexibility of Python build scripts with an incremental build speed that matches build systems written in C/C++. It requires Python 2.4-3.2 and natively supports Windows, Linux, Mac, Cygwin, MSVC and GCC.1 weekly downloads
Hajime! Bullet Chaos
An epic, 2D sidescrolling shooter with five levels, hard bosses, bullets everywhere, made by me with python, GIMP, music from artists at http://8bc.org/ and a bowl of ramen. What more could you ask for?0 weekly downloads
Divx Movie Streamer (DxMs)
An standalone Divx movie streamer implemented using python. Utilising the DivxFest.com website and VLC media player to grab and play the streams.8 weekly downloads
Pyk8055 Python module
A Python module to seamlessly interact with the Velleman K8055 kit via the K8055D.dll for Windows using Python ctypes4 weekly downloads
MV3D is an open source virtual world simulation framework written in Python. It was designed with scalability in mind and aims to be able to distribute a world across as many servers as needed while dynamically balancing the load.1 weekly downloads
URL PyExtractor
Programa que extrai a URL verdadeira de um link de segurança.6 weekly downloads
Lioness (Languages Interop Framework)
Framework for making Windows applications that are one .exe file in AutoHotKey_L,C++,C#, VB.NET,Java,Groovy,Common Lisp,Nemerle,Ruby,Python,PHP,Lua,Tcl,Perl,Jint,S#,WSH VBScript,HTML/JavaScript/CSS,COM, PowerShell without compiling . For .NET 4.1 weekly downloads
H.O.P.E. Integrated Systems
Your friendly neighborhood hackers for hire. We are a group of individuals providing our clients the best support and troubleshooting advice and some of what we believe to be the best open source software and OS. Enjoy!1,224 weekly downloads
teste jogo 3d
testing panda3d engine7 weekly downloads


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Results: Motocross of Nations – Sunday
Results from the 65th annual Motocross of Nations in France at the St. Jean d' Angely circuit. Moto results, team overall results and individual class results.
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Results from the 65th running of the Motocross of Nations from France at St. Jean d' Angely

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- David Toby Homel (Author)
The Speaking Cure. Douglas & McIntyre (purchase at Amazon.ca)
Reviewed by Robert Amussen
For the narrator of his novel, David Homel has imagined Aleksandar Jovic, a Belgrade clinical psychologist. The time is early in the breakup of the former Yugoslavia. Jovic's wife of twenty years is a psychologist as well who teaches at the University. They have a teenage son more devoted to listening to turbo rock than attending to his studies. Since the boy is afflicted with an incurable form of kidney disease, his parents are inclined to indulge him. As a government employee, Jovic is forbidden from having a private practice. However, like many of his colleagues, he gets around the prohibition by seeing his private patients in his apartment. One day, a man he takes to be a new patient turns out instead to be a government emissary. He tells Jovic not only that the government knows of his illegal private practice but that he must now report to work at the hospital treating veterans of the war suffering from post traumatic stress.
Jovic's new job assignment as a metaphor for the plight of the people of the former Yugoslavia makes sense as does the choice to dress him as a jaded east European intellectual with a world view of bemused irony at finding himself a passenger on a ship of fools and knaves. The difficulty with the novel is that neither Jovic nor the other principals emerge from behind their assigned roles to take on lives of their own. Their words and actions seem scripted. The narrative as a result becomes equally predetermined. When the novel ends with Jovic boarding a plane for Canada, it bears the unmistakable signature of the god out of the machine.
The novel's prose is serviceable enough and Homel's impressive understanding of the political and cultural dynamics works in its favor. While his sympathies are clearly on the side of the good guys, his fiction is not equal to the task he has set before it. It may be that in the present circumstances it is best to leave it to writers native to the region to tell us of their land's malaise without necessarily providing a remedy for a cure. One thinks of the likes of Aleksandar Tisma, Imre Kertés, and Danilo Kis.
Robert Amussen is a writer and editor living on Vancouver Island.
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MLA: Amussen, Robert. Shrink-wrapped. canlit.ca. Canadian Literature, 8 Dec. 2011. Web. 30 Sept. 2014.
This review originally appeared in Canadian Literature #184 (Spring 2005), (Grace, Dolbec, Kirk, Dawson, Appleford). (pg. 142 - 143)
***Please note that the articles and reviews from the Canadian Literature website (www.canlit.ca) may not be the final versions as they are printed in the journal, as additional editing sometimes takes place between the two versions. If you are quoting from the website, please indicate the date accessed when citing the web version of reviews and articles.


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Wednesday, Sept. 24
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Athlete of the Month
Congratulations to Max Warshawsky for winner the Planet Cycles Athlete of the Month.
Congratulations to Max Warshawsky for winner the Planet Cycles Athlete of the Month.
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text:
By Erica Kuschel.
If this doesn't make you want to visit Peru, then you don't deserve to see these pics. Shoo shoo scroll away.
Mostly it makes me want to visit Peru with some sort of llama tour guide
I love how in the last picture the llama's like "Okay. I'm done now."
The Hobbit chapter by chapter: Chapter 5: Riddles in the Dark
on monday a guy walked into the psychology class i'm in and sat next to me. about 30 minutes into class, he leans over and whispers, 'this isn't algebra.' and calmly stands up and walks out of the room. luv college
date a boy with nice cheek bones
date a boy who has a good taste in clothes
date a boy with a great laugh
date a boy who's hoodie you can borrow
date a boy with fantastic collarbones
date a boy who smiles constantly
date a boy with arms like damn
how to improve a skirt: add pockets. how to improve a dress: add pockets. how to improve jeans: add pockets. how to improve a cardigan: add pockets. how to improve your acne: add pockets. how to improve your shattered relationships: add pockets
(Source: rooftoqs)
omfg i did not fucking expect that
(Source: tastefullyoffensive)
when the person you hate tries joking with you
just watch it
(Source: epic-vines)


text:
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Fun fact: in the 1940s there were fabric rationing going on, so most dresses were cut to make the…
This is sheer genius!
I may make it too but shorten it to fit my height!
I may make the double tank top too.
I am planning to use this AS a rash guard pattern you complaining whiner!
I am making the same dress in cotton, but with appliqué motifs added in
And yes it's gonna be aw…
I may make this in cotton, with appliqué added in
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Design your own dresses with the latest special price technique kit.
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Click Here for Articles About GHOST MINE
Photo Flash: First Look at GHOST MINE on Syfy
January 15
7:09 2013
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Check out a first look at Syfy's upcoming new series Ghost Mine - set to air tomorrow night - below!
Forgotten in the remote woods of Oregon is one of the richest gold mines in the United States that was abandoned 80 years ago when a series of tragedies gave it an infamous reputation for being haunted. Now, a new owner has decided to take on the notorious legend and reopen the mine, assembling a rag-tag group of miners - both seasoned and new - to battle the elements in hopes of finding their fortune and teaming them with a pair of experienced paranormal investigators. In each of the six hour-long episodes, this strong-willed and historically superstitious group of miners will face the day-to-day challenges of mining, aided by the paranormal investigators who unravel the mysteries surrounding the mine, including historic Masonic connections and a spirit who has been known to haunt the area for generations. "Ghost Mine" is produced by 51 Minds with Mark Cronin ("Celebrity Paranormal Project," "Flavor of Love," "Rock of Love with Bret Michaels"), Dave Caplan and Jay Bluemke ("Ghost Hunters," "Ghost Hunters Academy") serving as executive producers.
Photos Courtesy of Syfy
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text:
Topic: Card Monsters / Brainstorming Ideas
These are all great ideas and suggestions from bmuell. I like the idea with second story map with live event-like restrictions. It would need to be very well thought out to be challenging enough.
IMO thing that needs change the most is live play. Current ranks (soldier/ninja/master/dragon) don't enable fair competition and prevent people from playing live mode. The problem especially for dragon game is that someone who just achieved minimum requirement to play dragon is matched up with epic-heavy decks. It's obvious that 4k strength deck has no chances against 9k deck. Also for players with 9k+ strength deck crushing easy opponents is not exactly what they expect from live play. Also someone could for example have a good ninja deck but weak master deck and would like to be compared with others who also just started on master level. My idea for live play would be quite big change and requires some work but I think it would take live play to a much higher level. When I enter live play I'd like to see a lobby similar to what can be seen in many simple multiplayer games (like triviador for example), where you can create live game rooms and chat with people. Chat room exclusively for live play would be very good I think, people could talk there to look for a right opponent. When you create game room other people could see your deck strength so they know if they have chance to compete. During events people could have option to choose to play event game or normal game. When creating live game room, there could be options like:
- game type: ranked, not ranked or event
- ranked game type: soldier, ninja, master or dragon game. Maybe some sub-ranks could be added as suggested previously.
- maybe option for ranked game to choose restrictions like no epic, max 1 epic, no level5 monsters, only lvl5 monsters, one color deck only..
- choose opponent deck strength (like 4000-7000). I think this option is the most important for live play to become more interesting for more players.
- options for not ranked and not event game like common only, no epic, yellow only and such
- maybe another ranking for 1 color only decks for each color (+generic maybe, dual color allowed), people could create game: 'blue only deck' and there would be ranking for blue decks, same for other colors. This option could be interesting when more expansions will be released
- maybe options to exclude cards with certain abilities from live play game, like no fear, no deathstrike, no crystal gain, no invincibility, no range, no doom. This maybe could be an interesting option for people with huge collection of cards. There could be created new interesting events based on this idea. New challenge for long time players to create good deck for example with no range and no shield ;)
- maybe even live battle between alliances could be possible. It would last 24 hours and people would be matched up according to deck strengths, alliance1 deck of highest strength would be matched up with highest strength deck from alliance2, second best alliance1 against second best alliance2 and so on. Also with option where leader chooses who will participate. There would be of course separate live ranking for alliances.
Things like 50 tickets per 24h, events, live ranking system, gold &xp rewards could stay the same as they are now. Note that better live play will encourage players to buy live play tickets.


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When I read the very good reviews here, I wonder if we just had their worst room. The location is beautiful: The hotel is spread out over different buildings in a big garden. All of them have a little terasse with a view outside - all of them except for ours. We had a tiny little room with simple furniture... More
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text:
FORT MYERS, Fla. — It wasn't exactly a watershed, but it was a first. On Tuesday morning, for the first time in his career, Xander Bogaerts took groundballs at third base rather than shortstop as part of his preparation to play as a third baseman and designated hitter for Team Netherlands in the World Baseball Classic. He will also take groundballs at third on Wednesday before starting at third base in an exhibition game against Boston College on Thursday.
Sox manager John Farrell suggested that Bogaerts had a favorable first day of work at the position.
"[It was] just an early look today. Typically corner infielders are going to use a one-handed fielding technique, which he naturally went to, just moving to third base," said Farrell. "He's an infielder. He's got a lot of natural ability and instincts there. We'll get two days of work days with him and then get him into a game on Thursday."
The shift is not without its challenges. Will Middlebrooks, for instance, needed months to become comfortable at third base when he moved there just prior to the start of his first professional assignment with the Lowell Spinners in 2008. The different demands on a third baseman are subtle but real.
"There's different angles. A shortstop's got the ability, one, he's further away from the ball so there's more of an internal clock, and fielding the ball at its highest point in that last hop. Here, it's more reactionary," said Farrell. "There's going to be a little bit of different angles to it. he's going to end up playing balls more straight up rather than being able to come around the ball. He'll come through a given play. Hands and feet are the same in terms of the timing of it. There's no real concern. It's just getting comfortable with the angle he'll be seeing a ground ball."
There can be benefit to even a brief introduction to third base. For instance, a year ago, the Orioles were able to move Manny Machado from short to third in the big leagues despite the fact that he'd played only two games at the position in the minor leagues thanks in part to the spring training instruction the phenom received at the position.
For now, with Will Middlebrooks in line to be the Sox' everyday third baseman, the Sox do not foresee a big league need for Bogaerts at third base.
"The major difference between [Machado's situation last year and Bogaerts' this year] is there's a pressing need there. Certainly, provided Will stays healthy, that need doesn't exist here," said Farrell. "At the same time, it's an opportunity to expose [Bogaerts] to the position and see where things go as he and [Jose Iglesias] and others get deeper in their careers and where they ultimately end up. As a young guy, you don't know how that body type is going to continue to mature physically, but by all indications, it seems like he can stay at shortstop."
That, certainly, is the case for now. But if Middlebrooks should get injured, or if down the line Iglesias establishes himself as an everyday shortstop, the fact that Bogaerts is getting some exposure to a new position has the potential to carry with it a positive impact.
We check in with Full Tilt, Full Time Tedy Bruschi for his take on the poor play of the New England Patriots, and where they go from here.\
The big nose tackle joins Dale and Holley the day after one of the worst losses in recent Patriots history.
Jackie Mac joins the guys to discuss her thoughts on a possible mid-season tournament in the NBA, LeBron's return to Cleveland, trade rumors with the Celtics and Red Sox, and Darrelle Revis' contract situation.
Jackie MacMullan of ESPN Boston to talk about the Lebron James Saga, the possibility of Rajon Rondo being traded, and the future of Marcus Smart.
Former coach of Celtics 1st-round pick Marcus Smart, Travis Ford joins MFB to talk about what Celtics fans should expect from the strong point guard. Among other things, Coach Ford says Smart will be a hard worker, and will improve his shooting ability.
Joe Castiglione does his annual wrap-up of the season by reading the poem by Bart Giamatti.
Mut and Rob discuss the "kids" and the variety of young bodies the Red Sox called upon this season. Specifically, they look at Bogaerts and Bradley, Jr. and where things went wrong. They give their opinions on which one will right the ship next season.
Description: Red Sox farm director Ben Crockett looks back at the 2014 Red Sox prospect season by answering listener questions about a number of Red Sox prospects as well as broader issues and themes in the farm system.
DJ Bean, WEEI.com, joined the guys to talk about the Bruins signing two young stars to 1-year contracts.
Rob Bradford is joined by WEEI.com Bruins beat writer DJ Bean, as well as Boston sports fan/blogger Turtleboy to talk all things Bruins free agency. With the B's recent moves, the conversation turns to where the Bruins might next turn and what kind of dent losing Jarome Iginla and Shawn Thornton might make.
DJ discusses Shawn Thornton's new deal, and the on going negotiations with Jerome Iginla
The top stories of the day as recounted by Kirk Minihane.
The guys opened the show discussing the Pats brutal Monday night loss.
John Dennis left the show mid segment.
Christian's nephew twisted his ankle and missed Sunday's game because he (supposedly) slipped while rushing down the stairs to stop his puppy from peeing on the floor. Lou addresses the Unsportsmanlike Conduct penalty from last night's game, in which a Chiefs player was flagged for dropping to his knees during a TD celebration. And Christian is dubious of some photos of LaRon Landry.
A familiar sentiment has arisen regarding the Patriots offense. Tom Brady is locking in on 2 guys (Edelman and Gronk) and no one else seems to be getting a look. A 37 year old, future Hall of Fame QB, has little to no weapons in 2014.
Lou, Christian and Tim break down last night's embarrassing loss on national television. They wonder just how much progress has been made towards building a championship team.
A less than chipper Bill Belichick joins Dale, Michael and Steve DeOssie the day after the Patriots got blown out on Monday Night in KC.
The big nose tackle joins Dale and Holley the day after one of the worst losses in recent Patriots history.
We check in with Full Tilt, Full Time Tedy Bruschi for his take on the poor play of the New England Patriots, and where they go from here.
Mut and Chris Villani are talking about the issues the Patriots defense faced against the Kansas City Chiefs, particularly in the running game.
The Patriots seemed to have no answer for the Kansas City Chiefs. Mut and Price talk about how the Patriots were exposed in all aspects of the game.
Mut is in for Mikey and Chris Price of WEEI.com is in with him. The guys talk about the Patriots defense, inability of the offense to stay on the field, and coaching adjustments or lack thereof.
Ben and Russ break down some rumors surrounding Real Madrid and Manchester United. Also on the docket is the MLS and your New England Revolution.
Dino, Gerry and Kirk talk about Gerry's passionate defense of Tom Brady, going to lunch and clock issues in the third edition of Breaking Balls.
Red Sox farm director Ben Crockett looks back at the 2014 Red Sox prospect season by answering listener questions about a number of Red Sox prospects as well as broader issues and themes in the farm system.
Dino, Gerry and Kirk talk about Gerry's passionate defense of Tom Brady, going to lunch and clock issues in the third edition of Breaking Balls.More from this show
Tim Hasselbeck on tonight's game at Arrowhead.More from this show
John Dennis left the show mid segment.More from this show
The guys opened the show discussing the Pats brutal Monday night loss.More from this show
The top stories of the day as recounted by Kirk Minihane.More from this show


text:
Celebrity Style: Vanessa Minnillo
by POPSUGAR Fashion 46 Reactions 0 Shares Print
Former MTV veejay Vanessa Minnillo recently celebrated her new limited edition line of FLIRT! cosmetics and her July cover for Lucky Magazine. I like the Laila Azhar dress she chose for the event, as it looks comfortable and dressy at the same time. (That seems to be the common theme throughout her wardrobe). Though, like many of her other fashion decisions, Vanessa played it safe, and she still makes it work. I just wish she had accessorized a bit more.
Celebrity Style
Vanessa Minnillo
cittypark 6 years
i liked her up until she started dating nick.
Michaelrcks 6 years
hansman17 7 years
hahah..no knives! Good one Coffee_bean! I think she looks great in her dress, she has a great body!
coffee_bean 7 years
no knives?
fashion-addict 7 years
the dress is cute .. loving the color .. but it just doesn't particularly work for her...
KhanAali 7 years
I love that dress, but pretty sure I could find that in Arden B for less than half the price and in a hotter color! Worried! :|
c0rkie 7 years
loving the dress!
f0o0fo0o0 7 years
sorry but i hate every thing about her
sea7marie 7 years
The dress would be cuter if it didn't have the hanging/draping in the front that kind of makes her look like she's trying to hide something. Although, I could just be influenced by my inherent dislike of her...
demeter 7 years
Love her.
potterlove 7 years
Cute dress. Just not my kind of color.
haute77 7 years
mall rat. too.much.makeup.
jusleah 7 years
I totaly agree w/ indie- her hair looks the same in every pic- she looks like lke she's afraid to do somethin new w/ her hair or is that the only style she can pull off? she def look blehhh...
indielove 7 years
she makes cute stuff look so boring. it's like she doesn't even try. her hair is always so meh.
lanuchan 7 years
i like her, and the dress!
teeniewahine 7 years
she's the wal-mart version of jessica alba. i think she's totally tacky, and prob should hire a new stylist!!!
lady-woods-03 7 years
I don't like the dress and I don't like her bc I still miss Nick and Jessica
FemmeFatale7 7 years
Her breasts look floppy because the dress slims up as it reaches her neck, leaving the twins exposed on the side. Not very flattering but she's young enough to pull it off. Right arm is looking lonely...A big, bold ring would've done the job.
azmarina 7 years
i think the color makes the dress look like curtains. if it had print or some other non-curtain color then maybe....
msshellokitty 7 years
I don't like the dress.
daniemre 7 years
She totally can use it :) She has a great body & she is so exotic an exocitic beauty♥
JaimeLeah526 7 years
I don't really know too much about her but I'd have to say that this look is pretty cute. I love the shoes and dress combo. I don't think her boobs look saggy or floppy. Who has ever heard of having your boobs up to your neck naturally?
sibalc 7 years
she bores me...
uacosj 7 years
I dont like the dress. It looks like something someone would wear at a club.
ticklezmepink 7 years
this dress looks kinda nice... it's not all that bad... i don't like it on her though... lol... not a big fan of her... but the dress is not that bad...
Link Love
- The model just scored a recurring role on Fox's new show Empire — Fashionista
- Here's 1 more way for you to keep up with the Kardashians — HuffPost Style
- We woke up and suddenly it was scarf season . . . — InStyle
- Here's a tattoo sleeve we can totally get behind — Style.com
- Why one-size-fits-all isn't always the worst of policies — The Cut
- You've already got the shoes to wear with your leather miniskirt — Who What Wear
- Escape into Kate Spade's on-the-road style — Racked
- Tips on tomboy style from a true master — Lucky
- The 1 closet space-saver you haven't tried yet — Stylelist


text:
Are you Robert Deans?Claim your profile
Publications (50)173.48 Total impact
- Nature Biotechnology 08/2014; · 32.44 Impact Factor
Article: Human adult bone marrow-derived stem cells decrease severity of lipopolysaccharide-induced acute respiratory distress syndrome in sheep.[Show abstract] [Hide abstract]
ABSTRACT: Acute respiratory distress syndrome (ARDS) is the most common cause of respiratory failure among critically ill subjects, sepsis and severe bacterial pneumonia being its most common causes. The only interventions that have proven beneficial are protective ventilation strategies and fluid conservation approaches. New therapies are needed to address this common clinical problem. Others and we have previously shown the beneficial effect of infusion of exogenous adult stem cells in different pre-clinical models of ARDS. In the present study endotoxin was infused intravenously into 14 sheep from which 6 received different doses of adult stem cells by intrabronchial delivery to evaluate the effect of stem cell therapy. After administration of endotoxin, there was a rapid decline in oxygenation to hypoxemic values, indicative of severe-to-moderate ARDS. None of the animals treated with saline solution recovered to normal baseline values during the 6 hours that the animals were followed. In contrast, sheep treated with a dose of 40 million adult stem cells returned their levels of oxygen in their blood to baseline two hours after the cells were infused. Similarly, improvements in carbon dioxide (CO2) clearance, pulmonary vascular pressures and inflammation were observed and confirmed by histology and by the decrease in lung edema. We concluded that instillation of adult non-hematopoietic stem cells can diminish the impact of endotoxin and accelerate recovery of oxygenation, CO2 removal and inflammation in the ovine model, making the use of adult stem cells a real alternative for future therapies for ARDS.Stem Cell Research & Therapy 03/2014; 5(2):42. · 3.65 Impact Factor
- [Show abstract] [Hide abstract]
ABSTRACT: Introduction: Early reports demonstrated the safety of adherent mesenchymal stromal cell (MSC) infusions in the hematopoietic stem cell transplantation (HCT) setting, as well as clinical efficacy for treatment of steroid refractory acute graft-versus-host disease (GVHD); however, two large, Phase III randomized, placebo-controlled trials of MSC for initial therapy or steroid refractory GVHD failed to meet their primary endpoints of durable complete response. Subset analyses demonstrated efficacy in selected patient populations, contributing to recent approvals of MSC for pediatric patients in Canada and New Zealand. Areas covered: In this review, we discuss the biologic and immunomodulatory properties of MSC and potential mechanisms involved. We review the results of prior clinical trials incorporating MSC for GVHD treatment or prophylaxis, the recent approvals in Canada and New Zealand, as well as future directions in the field. Expert opinion: The role of MSC infusions, in the prophylaxis and/or treatment of GVHD after HCT, continues to be under active investigation. Whether, and how, to incorporate MSC infusions is unclear, and ongoing questions include the source tissue type and culture methods, the timing and dosage of MSC product infusions, as well as the optimal clinical trial design and endpoints for assessment of clinical response.Expert opinion on biological therapy 02/2014; 14(2):231-46. · 3.22 Impact Factor
Article: Soliciting Strategies for Developing Cell-Based Reference Materials to Advance MSC Research and Clinical Translation.[Show abstract] [Hide abstract]
ABSTRACT: The mesenchymal stromal cell (MSC) field continues to rapidly progress with a number of clinical trials initiated and completed, with some reported successes in multiple clinical indications, and a growing number of companies established. The field nevertheless faces several challenges. Persistent issues include the definition of a MSC and comparability between MSC cell preparations. This is because of inherent cell heterogeneity, absence of markers unique to MSCs, and the difficulty in precisely defining them by developmental origin. Differences in the properties of MSCs also depend on the site of tissue harvest, phenotypic and genotypic characteristics of the donor and the isolation, storage and expansion methods used. These differences may be sufficient to ensure that attributes of the final MSC product could differ in potentially significant ways. As there are currently no gold standards, we propose using a reference material to establish methods of comparability amongst MSC preparations. We suggest four possible "ruler scenarios" and a method for global distribution. We further suggest that critical to establishing a reference material is the need to define protocols for comparing cells. The main purpose of this manuscript is to solicit input in establishing a consensus-based comparison. A comparative approach will be critical to all stages of translation to better clarify mechanisms of MSC actions, define optimal cell manufacturing process, ensure best practice clinical investigations, extend the use of a MSC product for new indications, protect a MSC product from imitators, and develop uniform reimbursement policies. Importantly, a reference material may enable a consensus on a practical definition of MSCs.Stem cells and development 01/2014; · 4.15 Impact Factor
Article: Human multipotent adult progenitor cells transcriptionally regulate fucosyltransferase VII.[Show abstract] [Hide abstract]
ABSTRACT: Targeted recruitment of leukocytes to sites of inflammation is a crucial event in normal host defense against pathogens, and attachment to and rolling on activated endothelial cells is a prerequisite first step for eventual leukocyte extravasation into sites of inflammation. These key events are mediated by interactions between glycosylated ligands expressed on leukocytes and selectins expressed on activated endothelium. Cell surface expression of selectin ligands on leukocytes is regulated by the rate-limiting enzyme fucosyltransferase VII (Fut7), and in its absence extravasation of leukocytes is severely inhibited. Multipotent adult progenitor cells (MAPCs) are an adherent cell population isolated from adult bone marrow. Intravenous administration of MAPCs provided functional improvement in multiple pre-clinical models of injury or disease, but the mechanisms by which these outcomes were achieved remain poorly understood. In vitro cell analysis studies including fluorescence-activated cell sorting, messenger RNA analysis, T-cell proliferation assays and endothelial cell binding assays were performed. The in vitro cell analysis studies characterized the ability of MAPCs to secrete factors that transcriptionally attenuate expression of Fut7 in T cells, blocking the terminal fucosylation event in the biosynthesis of selectin ligands and reducing T-cell binding to endothelial cells. This study presents the first example of a distinct regulatory mechanism involving transcriptional down-regulation of Fut7 by MAPCs that could modulate the trafficking behavior of T cells in vivo.Cytotherapy 10/2013; · 3.06 Impact Factor
Dataset: Movie S3
Dataset: Supplemental Material
Dataset: Movie S2
Dataset: Movie S1
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ABSTRACT: Multipotent adult progenitor cells (MAPCs) are adult adherent stromal stem cells currently being assessed in acute graft versus host disease clinical trials with demonstrated immunomodulatory capabilities and the potential to ameliorate detrimental autoimmune and inflammation-related processes. Our previous studies documented that MAPCs secrete factors that play a role in regulating T-cell activity. Here we expand our studies using a proteomics approach to characterize and quantify MAPC secretome components secreted over 72 hours in vitro under steady-state conditions and in the presence of the inflammatory triggers interferon-γ and lipopolysaccharide, or a tolerogenic CD74 ligand, RTL1000. MAPCs differentially responded to each of the tested stimuli, secreting molecules that regulate the biological activity of the extracellular matrix (ECM), including proteins that make up the ECM itself, proteins that regulate its construction/deconstruction, and proteins that serve to attach and detach growth factors from ECM components for redistribution upon appropriate stimulation. MAPCs secreted a wide array of proteases, some detectable in their zymogen forms. MAPCs also secreted protease inhibitors that would regulate protease activity. MAPCs secreted chemokines and cytokines that could provide molecular guidance cues to various cell types, including neutrophils, macrophages, and T cells. In addition, MAPCs secreted factors involved in maintenance of a homeostatic environment, regulating such diverse programs as innate immunity, angiogenesis/angiostasis, targeted delivery of growth factors, and the matrix-metalloprotease cascade.Stem cells translational medicine. 08/2013;
Article: Heart Grafts Tolerized Through Third-Party Multipotent Adult Progenitor Cells Can Be Retransplanted to Secondary Hosts With No Immunosuppression.[Show abstract] [Hide abstract]
ABSTRACT: Multipotent adult progenitor cells (MAPCs) are an adherent stem cell population that belongs to the mesenchymal-type progenitor cell family. Although MAPCs are emerging as candidate agents for immunomodulation after solid organ transplantation, their value requires further validation in a clinically relevant cell therapy model using an organ donor- and organ recipient-independent, third-party cell product. We report that stable allograft survival can be achieved following third-party MAPC infusion in a rat model of fully allogeneic, heterotopic heart transplantation. Furthermore, long-term accepted heart grafts recovered from MAPC-treated animals can be successfully retransplanted to naïve animals without additional immunosuppression. This prolongation of MAPC-mediated allograft acceptance depends upon a myeloid cell population since depletion of macrophages by clodronate abrogates the tolerogenic MAPC effect. We also show that MAPC-mediated allograft acceptance differs mechanistically from drug-induced tolerance regarding marker gene expression, T regulatory cell induction, retransplantability, and macrophage dependence. MAPC-based immunomodulation represents a promising pathway for clinical immunotherapy that has led us to initiate a phase I clinical trial for testing safety and feasibility of third-party MAPC therapy after liver transplantation.Stem cells translational medicine. 07/2013;
Article: Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting: Lessons Learned from First Clinical Trials.[Show abstract] [Hide abstract]
ABSTRACT: The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.Transplantation 06/2013; · 3.78 Impact Factor
Article: Interview: The commercialization of regenerative medicine into a routine healthcare offering.[Show abstract] [Hide abstract]
ABSTRACT: Robert Deans speaks to Alexandra Hemsley, Commissioning Editor Robert Deans has led Athersys Inc.'s (OH, USA) regenerative medicine research and development activities since February 2003 and has served as Vice President of Regenerative Medicine since October 2003. He was named Executive Vice President of Regenerative Medicine in April 2011. Deans is highly regarded as an expert in stem cell therapeutics, with over 20 years of experience in this field. From 2001 to 2003, Deans worked for early-stage biotechnology companies. Deans was formerly the Vice President of Research at Osiris Therapeutics, Inc. (MD, USA), a biotechnology company, from 1998 to 2001 and Director of Research and Development with the Immunotherapy Division of Baxter International, Inc. (IL, USA), a global healthcare company, from 1992 to 1998. Deans was also previously on the faculty at University of Southern California Medical School in Los Angeles (CA, USA) between 1981 and 1998, in the departments of microbiology and neurology at the Norris Comprehensive Cancer Center. Deans was an undergraduate at Massachusetts Institute of Technology, received his PhD at the University of Michigan and did his post-doctoral work at University of California in Los Angeles, CA, USA. Aside from his Athersys responsibilities, Deans has a very active role within the International Society for Cellular therapy, specifically in Chairing the Commercialization Committee, and the Alliance for Regenerative Medicine, where he is co-chair of the Science and Technology committee.Regenerative Medicine 05/2013; 8(3):251-6. · 3.87 Impact Factor
Article: Clinical-Grade Multipotent Adult Progenitor Cells Durably Control Pathogenic T Cell Responses in Human Models of Transplantation and Autoimmunity.[Show abstract] [Hide abstract]
ABSTRACT: A major goal of immunotherapy remains the control of pathogenic T cell responses that drive autoimmunity and allograft rejection. Adherent progenitor cells, including mesenchymal stromal cells (MSCs) and multipotent adult progenitor cells (MAPCs), represent attractive immunomodulatory cell therapy candidates currently active in clinical trials. MAPCs can be distinguished from MSCs on the basis of cellular phenotype, size, transcriptional profile, and expansion capacity. However, despite their ongoing evaluation in autoimmune and allogeneic solid organ transplantation settings, data supporting the immune regulatory potential of clinical-grade MAPCs are limited. In this study, we used allogeneic islet transplantation as a model indication to assess the ability of clinical-grade MAPCs to control T cell responses that drive immunopathology in human autoimmune disease and allograft rejection. MAPCs suppressed T cell proliferation and Th1 and Th17 cytokine production while increasing secretion of IL-10 and were able to suppress effector functions of bona fide autoreactive T cells from individuals with type 1 diabetes mellitus, including killing of human islets. Furthermore, MAPCs favored the proliferation of regulatory T cells during homeostatic expansion driven by γ-chain cytokines and exerted a durable, yet reversible, control of T cell function. MAPC suppression required licensing and proceeded via IDO-mediated tryptophan catabolism. Therefore, the common immune modulatory characteristics of clinical-grade MAPCs shown in this study suggest that they can be regarded as an alternative source of adult progenitor cells with similar clinical usefulness to MSCs. Taken collectively, these findings may guide the successful deployment of both MSCs and MAPCs for the amelioration of human autoimmunity and allograft rejection.The Journal of Immunology 04/2013; · 5.52 Impact Factor
Article: Human Multipotent Adult Progenitor Cells Are Nonimmunogenic and Exert Potent Immunomodulatory Effects on Alloreactive T-Cell Responses[Show abstract] [Hide abstract]
ABSTRACT: Multipotent adult progenitor cells (MAPCs) are bone marrow-derived nonhematopoietic stem cells with a broad differentiation potential and extensive expansion capacity. A comparative study between human mesenchymal stem cells (hMSCs) and human MAPCs (hMAPCs) has shown that hMAPCs have clearly distinct phenotypical and functional characteristics from hMSCs. In particular, hMAPCs express lower levels of MHC class I than hMSCs and cannot only differentiate into typical mesenchymal cell types but can also differentiate in vitro and in vivo into functional endothelial cells. The use of hMSCs as cellular immunomodulatory stem cell products gained much interest since their immunomodulatory capacities in vitro became evident over the last decade. Currently, the clinical grade stem cell product of hMAPCs is already used in clinical trials to prevent graft-versus-host disease (GVHD), as well as for the treatment of acute myocardial infarct, ischemic stroke, and Crohn's disease. Therefore, we studied the immune phenotype, immunogenicity, and immunosuppressive effect of hMAPCs in vitro. We demonstrated that hMAPCs are nonimmunogenic for T-cell proliferation and cytokine production. In addition, hMAPCs exert strong immunosuppressive effects on T-cell alloreactivity and on T-cell proliferation induced by mitogens and recall antigens. This immunomodulatory effect was not MHC restricted, which makes off-the-shelf use promising. The immunosuppressive effect of hMAPCs is partially mediated via soluble factors and dependent on indoleamine 2,3-dioxygenase (IDO) activity. At last, we isolated hMAPCs, the clinical grade stem cell product of hMAPCs, named MultiStem, and hMSCs from one single donor and observed that both the immunogenicity and the immunosuppressive capacities of all three stem cell products are comparable in vitro. In conclusion, hMAPCs have potent immunomodulatory properties in vitro and can serve as a valuable cell source for the clinical use of immunomodulatory cellular stem cell product.Cell Transplantation 01/2013; 22(10). · 4.42 Impact Factor
Article: Treatment-emergent adverse events after infusion of adherent stem cells: the MiSOT-I score for solid organ transplantation.[Show abstract] [Hide abstract]
ABSTRACT: BACKGROUND: Cellular therapy after organ transplantation is emerging as an intriguing strategy to achieve dose reduction of classical immunosuppressive pharmacotherapy. Here, we introduce a new scoring system to assess treatment-emergent adverse events (TEAEs) of adherent stem cell therapies in the clinical setting of allogeneic liver transplantation (for example, the MiSOT-I trial Eudract CT: 200901779525). METHODS: The score consists of three independent modalities (set of parameters) that focus on clinically relevant events early after intravenous or intraportal stem cell infusion: pulmonary toxicity, intraportal-infusional toxicity, and systemic toxicity. For each modality, values between 0 (no TEAE) and 3 (severe TEAE) were defined. The score was validated retrospectively on a cohort of n=187 recipients of liver allografts not receiving investigational cell therapy between July 2004 and December 2010. These patients represent a control population for further trials. Score values were calculated for days 1, 4, and 10 after liver transplantation. RESULTS: Grade 3 events were most commonly related to the pulmonary system (3.5% of study cohort on day 4). Almost no systemic-related TEAEs were observed during the study period. The relative frequency of grade 3 events never exceeded 5% over all modalities and time points. A subgroup analysis for grade 3 patients provided no descriptors associated with severe TEAEs. CONCLUSION: The MiSOT-I score provides an assessment tool to score specific adverse events that may occur after adherent stem cell therapy in the clinical setting of organ transplantation and is thus a helpful tool to conduct a safety study.Trials 11/2012; 13(1):211. · 2.21 Impact Factor
Article: Development of a surrogate angiogenic potency assay for clinical-grade stem cell production.[Show abstract] [Hide abstract]
ABSTRACT: Clinical results from acute myocardial infarction (AMI) patients treated with MultiStem®, a large-scale expanded adherent multipotent progenitor cell population (MAPC), have demonstrated a strong safety and benefit profile for these cells. The mechanism of benefit with MAPC treatment is a result, in part, of its ability to induce neovascularization through trophic support. Production of clinical-grade stem cell products requires the development of lot-release criteria based on potency assays that directly reflect the fundamental mechanistic pathway underlying the therapeutic response to verify manufacturing process consistency and product potency. Using an in vitro endothelial tube formation assay, a potency assay has been developed that reflects MAPC pro-angiogenic activity. Serum-free conditioned media collected from MAPC culture induced endothelial tube formation. A proteomic survey of angiogenic factors produced by the cells in vitro revealed candidate factors linked to angiogenic potency. Three cytokines, chemokine (C-X-C motif) ligand 5 (CXCL5), interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF), were required for this angiogenic activity. Depletion of any of these factors from the media prevented tube formation, while adding back increasing amounts of these cytokines into the depleted serum-free conditioned media established the lower limits of each of the cytokines required to induce angiogenesis. A necessary threshold of angiogenic factor expression was established using an in vitro angiogenesis assay. By correlating the levels of the cytokines required to induce tube formation in vitro with levels of the factors found in the spent media from manufacturing production runs, detection of these factors was identified as a surrogate potency assay with defined pass/fail criteria.Cytotherapy 06/2012; 14(8):994-1004. · 3.06 Impact Factor
Article: The potential of mesenchymal stromal cells as a novel cellular therapy for multiple sclerosis.[Show abstract] [Hide abstract]
ABSTRACT: Multiple sclerosis (MS) is an inflammatory neurodegenerative disease of the CNS for which only partially effective therapies exist. Intense research defining the underlying immune pathophysiology is advancing both the understanding of MS as well as revealing potential targets for disease intervention. Mesenchymal stromal cell (MSC) therapy has the potential to modulate aberrant immune responses causing demyelination and axonal injury associated with MS, as well as to repair and restore damaged CNS tissue and cells. This article reviews the pathophysiology underlying MS, as well as providing a cutting-edge perspective into the field of MSC therapy based upon the experience of authors intrinsically involved in MS and MSC basic and translational science research.Immunotherapy 05/2012; 4(5):529-47. · 2.39 Impact Factor
Article: Intra-cerebroventricular transplantation of human bone marrow-derived multipotent progenitor cells in an immunodeficient mouse model of Mucopolysaccharidosis type I (MPS-I).[Show abstract] [Hide abstract]
ABSTRACT: Mucopolysaccharidosis type I (MPS-I; Hurler syndrome) is an inborn error of metabolism caused by lack of the functional lysosomal glycosaminoglycan (GAG)-degrading enzyme α-L-iduronidase (IDUA). Without treatment, the resulting GAG accumulation causes multisystem dysfunction and death within the first decade. Current treatments include allogeneic hematopoietic stem cell transplantation (HSCT) and enzyme replacement therapy. HSCT ameliorates clinical features and extends life but is not available to all patients, and inadequately corrects the most devastating features of the disease including mental retardation and skeletal deformities. Recent developments suggest that stem cells can be used to deliver needed enzymes to the central nervous system. To test this concept, we transplanted bone marrow derived normal adult human MultiStem® cells into the cerebral lateral ventricles of immunodeficient MPS-I neonatal mice. Transplanted cells and human-specific DNA were detected in the hippocampal formation, striatum, and other areas of the central nervous system. Brain tissue assays revealed significant long-term decrease in GAG levels in the hippocampus and striatum. Sensorimotor testing 6 months after transplantation demonstrated significantly improved Rotarod performance of transplanted mice in comparison to nontransplanted and sham-transplanted control animals. These results suggest that a single injection of MultiStem cells into the cerebral ventricles of neonatal MPS-I mice induces sustained reduction in GAG accumulation within the brain, and modest long-term improvement in sensorimotor function.Cell Transplantation 04/2012; · 4.42 Impact Factor
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ABSTRACT: Multipotent, bone marrow-derived stromal cells (BMSCs, also known as mesenchymal stem cells [MSCs]), are culture-expanded, nonhematopoietic cells with immunomodulatory effects currently being investigated as novel cellular therapy to prevent and to treat clinical disease associated with aberrant immune response. Emerging preclinical studies suggest that BMSCs may protect against infectious challenge either by direct effects on the pathogen or through indirect effects on the host. BMSCs may reduce pathogen burden by inhibiting growth through soluble factors or by enhancing immune cell antimicrobial function. In the host, BMSCs may attenuate pro-inflammatory cytokine and chemokine induction, reduce pro-inflammatory cell migration into sites of injury and infection, and induce immunoregulatory soluble and cellular factors to preserve organ function. These preclinical studies provide provocative hints into the direction MSC therapeutics may take in the future. Notably, BMSCs appear to function as a critical fulcrum, providing balance by promoting pathogen clearance during the initial inflammatory response while suppressing inflammation to preserve host integrity and facilitate tissue repair. Such exquisite balance in BMSC function appears intrinsically linked to Toll-like receptor signaling and immune crosstalk.Blood 02/2012; 119(8):1801-9. · 9.78 Impact Factor
Top Journals
- Cytotherapy (4)
- Transplantation (3)
- Cell Transplantation (2)
- Cytotherapy (2)
- Cell Transplantation (2)
University Hospital Regensburg
Regensburg, Bavaria, Germany
- Klinik für Chirurgie
Case Western Reserve University
Cleveland, OH, United States
- Department of Neurosciences
Athersys Inc.Cleveland, Ohio, United States
Erasmus MC
Rotterdam, South Holland, Netherlands
- Department of Internal Medicine
Peninsula Cancer InstituteWilliamsburg, Virginia, United States
Georgia Health Sciences University
Augusta, GA, United States
- Department of Neurology


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A Victorian living room is revived through the use of gold and bronze painting techniques.
Create a textured metallic finish using this elegant technique.
Jeff Devlin turns a repulsive green & gold bathroom into a beautiful space.
Matt and homeowner Erin gut her gold bathroom and give it a total redo.
A rich coat of paint and gold-leaf accents add a dash of panache to the Victorian-era fireplace.
Matt turns a badly outdated '70s bathroom into a simple, classy retreat.
This gold-leaf finish for an embossed wall or ceiling is made affordable with the use of composition-metal gold leaf.
Created a gilded finishes in your home using this gold-leafing technique.


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Member StoriesDiscussion
Why is there even a 9/11 memorial in Bremerton?!
British member of the PACE Mike Hancock on Wednesday accused the EU of manufacturing the humanitarian crisis in Ukraine, which it then blamed on Russia.
HONOLULU — Queen's Medical Center is currently treating a patient who may be infected with the deadly Ebola virus. The patient checked in Wednesday morning after experiencing symptoms.
The Argentine president slammed the United States saying they are sending "financial and speculative attacks" and wanting a "return to the past, when Argentina was on its knees," in her address to the nation Tuesday evening.
In his speech to the United Nations General Assembly last week, Obama sounded less statesman and more salesman, with the usual pitch that American leadership is all benevolent and virtuous. America is pursuing, America is committed, America is prepared… and so on and on went the tiresome egocentric rhetoric.
Prisoner swaps in Ukraine are in danger of stalling as rebels say they will no longer tolerate Kiev's practice of producing random people for exchange instead of actual members of militia and political prisoners.
The 10-day NATO exercise code named «BREEZE 2014» has ended in Black Sea. The exercise, which included the use of electronic warfare and electronic intelligence aircraft such as the Boeing EA-18G Growler and the Boeing E3 Sentry Airborne Warning and Control System (AWACS), coincided with the shootdown of Malaysian Airlines Flight 17 in eastern Ukraine, some 40 miles from the Russian border. NATO ships and aircraft had the Donetsk and Luhansk regions under total radar and electronic surveillance.
Whatever is occurring in Hong Kong, it bears no relation to what is being reported about it in the Western print and TV media. These reports spin the protests as a conflict between the demand for democracy and a tyrannical Chinese government
The United States supports full investigation into the mass graves discovered in eastern Ukraine's Donetsk region, US State Department Spokesperson Jen Psaki has said during a press briefing .
The shocking revelation from a large government supplier specializing in "high risk events" suggests that not only did someone know that the Ebola virus would be reaching America, but that they knew exactly when it would happen.
*hyperlinks live at source*
Between right now and victory over a psychopathically evil .01%, a critical mass of human beings must accomplish two tasks:
Recognize this evil clearly.
Recognize real leadership.
Among ~100 areas of crucial concern, perhaps the easiest-to-prove "Big Lie" crimes of the .01% are:
Unlawful Wars of Aggression based on lies known to be false as they are told (here, here, here, here),
Bankster-looting economics (here, here, here, here),
Lying sacks of spin corporate media that attempt to "cover" the crimes from public recognition.
The terms evil and psychopath are academically accurate given the easily documented and proved crimes in just the above three areas that annually kill millions, harm billions, and loot trillions.
A Coup In Camelot is a documentary that shines a fresh light on the forensic 'fingerprints' surrounding that fateful day in November of 1963, when President John F. Kennedy was assassinated. The film features compelling analysis by the top medical, forensic and research experts in the country.
A Coup In Camelot provides an in-depth study of how Secret Service protocols were not followed, and offers analysis of the famous Zapruder film with stunning 6k digital scans to show a clarity 10 times greater than High Definition. Modern day forensics and wound ballistic techniques are applied to determine where the fatal head shot came from. Details of a casket shell game and shocking medical alterations done to the President's body are revealed, to uncover a chilling story of conspiracy.
Link to trailer: http://vimeo.com/107215297
105 minutes, filmed and presented in 1080p HD.
At a meeting with Russia's Security Council, President Vladimir Putin has said the problem of the country's 'informational space' security is of top priority, but assured the state has no intentions of limiting access to the web.
Young people who torture and kill animals are prone to violence against people later in life if it goes unchecked, studies have shown. A new federal category for animal cruelty crimes will help root out those pet abusers before their behavior worsens and give a boost to prosecutions, an animal welfare group says.
Prospective students in the United States who can't afford to pay for college or don't want to rack up tens of thousands in student debt should try their luck in Germany. Higher education is now free throughout the country, even for international students. Yesterday, Lower Saxony became the last of seven German states to abolish tuition fees, which were already extremely low compared to those paid in the United States.
Law enforcement agencies have been buying and distributing Computercop, advising citizens that the software is the "first step" for protecting their kids; one sheriff bought copies for every family in the county.
But Computercop isn't security software -- quite the opposite; it's classic malware. The software, made in New York by a company that markets to law enforcement, is a badly designed keylogger that stores thingstyped into the keyboard -- potentially everything typed on the family PC -- passwords, sensitive communications, banking logins, and more, all stored on the hard drive, either in the clear, or with weak, easily broken encryption. And Computercop users are encouraged to configure the software to email dumps from the keylogger to their accounts (to spy on their children's activity), so that all those keystrokes are vulnerable to interception by anyone between your computer and your email server.
Share trades worth more than the size of Sweden's economy had to be cancelled in Tokyo after what is believed to be the biggest "fat finger" error on record.
It is thought to be the most extreme example of a trader in financial markets inputting hopelessly wrong figures while working under intense pressure. The identity of the trader is not yet known.
Mistaken orders for shares in 42 major Japanese companies, including household names such as Toyota, Honda, Canon and Sony, totalling ¥67.78trn (£381bn) were overturned, according to data from the Japan Securities Dealers Association.
The biggest single order was for 1.96 billion shares of Toyota, the world's biggest car maker, worth ¥12.68trn.
Health experts all over the United States are promising us that we do not need to be worried about Ebola whatsoever. Even though one case has already been confirmed in Dallas, Texas and another potential case is being monitored, health authorities assure us that we have the greatest health system in the history of the planet and that we will be able to handle any isolated cases very easily. And all over the mainstream media on Wednesday, there were headlines declaring that the arrival of Ebola in America is a non-event. One example is this headline from Bloomberg: "Ebola in America? Don't Worry About It". So are they right?
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Starbucks Name Mystery Solved?
Testing an Electric Harley Without the Vroom (VIDEO)
State Fair a Bonanza for Scientific Research
Where are the Women Sports Pundits?
"Fish Fraud" Common Problem in US
Written by Pat's Papers | Friday, 17 June 2011 12:30 PM
Next time you order fish, look at your plate carefully, as you could be the victim of a bait-and-switch scam. The Sun Sentinel says "fish fraud" is more common than you think. According to a new study, fish sold in the US as red snapper, wild salmon and Atlantic cod is falsely labeled 25 to 70 percent of the time. Be wary of lower-than-normal fish prices—it could be a sign that you're buying something that's been falsely labeled. Buying whole fish is another way to ensure you get what you are paying for.
Download the study: Bait and Switch: How Seafood Fraud Hurts Our Oceans, Our Wallets and Our Health
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The Press Newspaper
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Air Force Airman Brandon M. Sharples graduated from basic military training at Lackland Air Force Base, San Antonio, Tex.
He is the son of Kimberly Sharples of Bowling Green, and the brother of Antony Sharples, of Genoa. He graduated from Oak Harbor High School in 2004.
$15 Hourly wage
The "Fight for $15" campaign proposes a $15/hour wage for fast food workers. Do you agree?
Yes (6 Votes)
No (24 Votes)
1457510002 [{"id":"18","title":"Yes","votes":"6","pct":20,"type":"x","order":"1","resources":[]},{"id":"19","title":"No","votes":"24","pct":80,"type":"x","order":"2","resources":[]}] ["#194e84","#3b6b9c","#1f242a","#37414a","#60bb22","#f2babb"] sbar 160 160 /component/communitypolls/vote/8-15-hourly-wage No answer selected. Please try again. Thank you for your vote. Answers Votes


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- Alpha Invitations Going Out for Bloodborne
- Gone Home Map Created for Counterstrike: Global Offensive
- Goat Simulator Out for iOS and Android Today
- Destiny Has Grossed Over $325 Million in Sales Worldwide
- WoW Character Name Reclamation Coming
- Final Fantasy Type-0 Release Date Leaked
- Sega Talks Alien Isolation 'Survivor' Mode
- Fresh The Evil Within Gameplay Trailer
- Far Cry 4 PAX Prime Arena Trailer
- Mornin '14
- Bungie Could Lose $2.5 Million Due to Review Scores
- New Assassin's Creed Unity Co-Op Gameplay Trailer
- Mortal Kombat X Controller Spotted in the Wild
- September Xbox Games with Gold
- The Order: 1886 Dev Defends Destiny Against Low Review Scores
- Super Smash Bros. for 3DS Breaks 1 Million Sales
- Divinity: Original Sin Enriched With Free DLC
- Borderlands Getting Steamworks Multiplayer Support
- REVIEW: Destiny
- Mornin '14
- The Evil Within
TGS 2014 Trailer
- Far Cry 4
PAX Prime Arena Trailer
- Alien: Isolation
Survivor Mode Trailer
- Assassin's Creed Unity
CoOp Gameplay Trailer
- Borderlands: The Pre-Sequel
Developer's Diary Episode 3
- Far Cry 4
The Mighty Elephants of Kyrat Trailer
- Forza Horizon 2
Launch Trailer
- Far Cry 3
Patch 1.05
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Patch v1.02 to v1.03
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Patch 1.04
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Patch 1.02
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Patch 1.4 to 1.5
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Patch v18.104.22.168
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Patch v126.96.36.199
Capcom has confirmed that their upcoming action adventure, DmC: Devil May Cry, is going to be on sale come January 15, 2013, while the PC edition will become available later during that same year. Here's the official word from Capcom (as posted on Capcom Unity Blog):
Okay Unity, let's talk DmC. We've got two big announcements regarding Ninja Theory's unique take on the Devil May Cry brand.
First, we've got an update on the release timing. The game is now set to release on Playstation 3 and Xbox 360 on January 15th, 2013 in both North America and Europe. While I wish it was coming out tomorrow, this does contribute further evidence to the theory that January is a great month for Capcom. In the past, January has seen the release of such titles as Resident Evil 4, Devil May Cry 3: Special Edition, Lost Planet: Extreme Condition, and Resident Evil Revelations (well, in Europe, anyway ^^;;)
Second is that a PC version of the game is also coming later in 2013, and that its development is already well underway.
Additionally, we've got some new info and assets on the game's supporting character, Kat. I've seen a lot of speculation and inquiry about this character, who has appeared in a number of previous video assets, so hit the jump for some text and images on this new addition to the Devil May Cry lore compendium (lorependium).
|May 22 2012, 06:14 pm EDT
|May 22 2012, 07:11 pm EDT


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DC Universe Online beta will be glad to read that a new trio of free games awaits them in the coming calendar year. PSN multiplayer game Lead & Gold: Gangs of the Wild West, PlayStation classic Spyro the Dragon, and PSN Mini Pipe Madness will unlock for free to all PS Plus members as of January 4, 2011. A handful of discounts will also become available, as well as a duo of featured themes and avatars.
For those of you not yet enjoying December's PS Plus spoils, you've got until the aforementioned January date to snag 'em -- Dead Nation for $12 instead of $15? Yes, please! That said, at this point, you'll likely be the third or fourth person queuing up to speak with Superman in DCUO, but hopefully it'll be worth the wait.
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