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Discover our weekly selection of scientific and medical publications in the field of myology and of neuromuscular diseases : summary of each publication aimed at the general reader, highlighting the main points of the article and the authors' conclusions
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26/09/2014 - Identification of a novel, inherited neuromuscular disease
Synaptotagmin 2 is a synaptic vesicle protein that functions as a calcium sensor for neurotransmission but has not been previously associated with human disease. Via whole-exome sequencing, heterozygous missense mutations in the C2B calcium-binding domain of the gene encoding Synaptotagmin 2 were identified in two multigenerational families presenting with peripheral motor neuron syndromes. An essential calcium-binding aspartate residue, Asp307Ala, was disrupted by a c.920A>C change in one family that presented with an autosomal-dominant presynaptic neuromuscular junction disorder resembling Lambert-Eaton myasthenic syndrome. A c.923C>T variant affecting an adjacent residue (p.Pro308Leu) produced a presynaptic neuromuscular junction defect and a dominant hereditary motor neuropathy in a second family. Characterization of the mutation homologous to the human c.920A>C variant in Drosophila Synaptotagmin revealed a dominant disruption of synaptic vesicle exocytosis using this transgenic model. These findings indicate that Synaptotagmin 2 regulates neurotransmitter release at human peripheral motor nerve terminals. In addition, mutations in the Synaptotagmin 2 C2B domain represent an important cause of presynaptic congenital myasthenic syndromes and link them with hereditary motor axonopathies.
Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy. Herrmann DN, Horvath R, Sowden JE, et al. Am J Hum Genet. 2014 Sep 4;95(3):332-9.
26/09/2014 - Motor and cognitive delay in DMD
This study examined the relationship between delay in the age of first independent walking and cognitive impairment in boys with Duchenne muscular dystrophy (DMD) to assess how age of diagnosis might be improved. The records of 179 boys with DMD evaluated by the senior author between 1989 and June 2012 were reviewed. Delay in walking was defined as occurring at or greater than 16 months of age. Cognitive impairment was identified by school placement in special education or lower than expected grade level during the elementary school years. Delay in walking and cognitive impairment were highly correlated (P ≤ .0001). If cognitively delayed, boys with DMD were 3 times more likely to have a delay in walking. This association was shown to be independent from the rate of motor degeneration (P = .9) and the age of diagnosis (P = .6, combined average = 5.1 ± 2 years). Delay in the onset of walking in boys with DMD was strongly associated with cognitive delay. The authors suspect that primary care givers overlook DMD as a possible cause of delay in the age of independent walking when early features of cognitive delay are also apparent. DMD should be included among those disorders causing global developmental delay. Recognition of this association could substantially decrease the age of diagnosis for many boys with DMD. The authors suggest that the standard evaluation for boys with global developmental delay include an inexpensive and sensitive serum creatine kinase test.
Motor and Cognitive Delay in Duchenne Muscular Dystrophy: Implication for Early Diagnosis. Mirski KT, Crawford TO. J Pediatr. 2014 Aug 19. pii: S0022-3476(14)00628-3.
26/09/2014 - Inhibition of JAK-STAT signaling stimulates adult satellite cell function
Diminished regenerative capacity of skeletal muscle occurs during adulthood. Here, the authors identified a reduction in the intrinsic capacity of mouse adult satellite cells to contribute to muscle regeneration and repopulation of the niche. Gene expression analysis identified higher expression of JAK-STAT signaling targets in 3-week-old relative to 18-month-old mice. Knockdown of Jak2 or Stat3 significantly stimulated symmetric satellite stem cell divisions on cultured myofibers. Genetic knockdown of Jak2 or Stat3 expression in prospectively isolated satellite cells markedly enhanced their ability to repopulate the satellite cell niche after transplantation into regenerating tibialis anterior muscle. Pharmacological inhibition of Jak2 and Stat3 activity similarly stimulated symmetric expansion of satellite cells in vitro and their engraftment in vivo. Intramuscular injection of these drugs resulted in a marked enhancement of muscle repair and force generation after cardiotoxin injury. Together these results reveal age-related intrinsic properties that functionally distinguish satellite cells and suggest a promising therapeutic avenue for the treatment of muscle-wasting diseases.
Inhibition of JAK-STAT signaling stimulates adult satellite cell function. Price FD, von Maltzahn J, Bentzinger CF, et al. Nat Med. 2014 Sep 7. doi: 10.1038/nm.3655. [Epub ahead of print]
26/09/2014 - Morpholino antisense oligonucleotides: a new molecular target for SMA
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by the loss of Survival Motor Neuron-1 (SMN1). In all SMA patients, a nearly identical copy gene called SMN2 is present, which produces low levels of functional protein owing to an alternative splicing event. To prevent exon-skipping, the authors targeted an intronic repressor, Element1 (E1), located upstream of SMN2 exon 7 using Morpholino-based antisense oligonucleotides (E1(MO)-ASOs). A single intracerebroventricular injection in the relatively severe mouse model of SMA (SMNΔ7 mouse model) elicited a robust induction of SMN protein, and mean life span was extended from an average survival of 13 to 54 days following a single dose, consistent with large weight gains and a correction of the neuronal pathology. Additionally, E1(MO)-ASO treatment in an intermediate SMA mouse (SMN(RT) mouse model) significantly extended life span by ∼700% and weight gain was comparable with the unaffected animals. While a number of experimental therapeutics have targeted the ISS-N1 element of SMN2 pre-mRNA, the development of E1 ASOs provides a new molecular target for SMA therapeutics that dramatically extends survival in two important pre-clinical models of disease.
Morpholino antisense oligonucleotides targeting intronic repressor Element1 improve phenotype in SMA mouse models. Osman EY, Miller MR, Robbins KL, et al. Hum Mol Genet. 2014 Sep 15;23(18):4832-45.
26/09/2014 - Generation of a mouse model containing an X-Linked DUX4 transgene
Facioscapulohumeral muscular dystrophy (FSHD) is an enigmatic disease associated with epigenetic alterations in the subtelomeric heterochromatin of the D4Z4 macrosatellite repeat. Each repeat unit encodes DUX4, a gene that is normally silent in most tissues. Besides muscular loss, most patients suffer retinal vascular telangiectasias. To generate an animal model, a doxycycline-inducible transgene encoding DUX4 and 3' genomic DNA was introduced into a euchromatic region of the mouse X chromosome. Without induction, DUX4 RNA was expressed at low levels in many tissues and animals displayed a variety of unexpected dominant leaky phenotypes, including male-specific lethality. Remarkably, rare live-born males expressed DUX4 RNA in the retina and presented a retinal vascular telangiectasia. By using doxycycline to induce DUX4 expression in satellite cells, impaired myogenesis in vitro and in vivo was observed. This mouse model, which shows pathologies due to FSHD-related D4Z4 sequences, is likely to be useful for testing anti-DUX4 therapies in FSHD.
>Full text
Dominant Lethal Pathologies in Male Mice Engineered to Contain an X-Linked DUX4 Transgene. Dandapat A, Bosnakovski D, Hartweck LM, et al. Cell Rep. 2014 Sep 11;8(5):1484-96
26/09/2014 - Single-molecule imaging identifies altered dynamics of calcium channels
Single-molecule (SM) fluorescence microscopy allows the imaging of biomolecules in cultured cells with a precision of a few nanometres but has yet to be implemented in living adult animals. Here split-GFP (green fluorescent protein) fusions and complementation-activated light microscopy (CALM) were used for subresolution imaging of individual membrane proteins in live Caenorhabditis elegans (C. elegans). In vivo tissue-specific SM tracking of transmembrane CD4 and voltage-dependent Ca2+ channels (VDCC) was achieved with a precision of 30 nm within neuromuscular synapses and at the surface of muscle cells in normal and dystrophin-mutant worms. Through diffusion analyses, the authors reveal that dystrophin is involved in modulating the confinement of VDCC within sarcolemmal membrane nanodomains in response to varying tonus of C. elegans body-wall muscles. CALM expands the applications of SM imaging techniques beyond the petri dish and opens the possibility to explore the molecular basis of homeostatic and pathological cellular processes with subresolution precision, directly in live animals.
>Full text
In vivo single-molecule imaging identifies altered dynamics of calcium channels in dystrophin-mutant C. elegans. Zhan H, Stanciauskas R, Stigloher C, et al. Nat Commun. 2014 Sep 18;5:4974.
26/09/2014 - STAT3 signalling promotes skeletal muscle repair
The progressive loss of muscle regenerative capacity with age or disease results in part from a decline in the number and function of satellite cells, the direct cellular contributors to muscle repair. However, little is known about the molecular effectors underlying satellite cell impairment and depletion. Elevated levels of inflammatory cytokines, including interleukin-6 (IL-6), are associated with both age-related and muscle-wasting conditions. The levels of STAT3, a downstream effector of IL-6, are also elevated with muscle wasting, and STAT3 has been implicated in the regulation of self-renewal and stem cell fate in several tissues. This study shows that IL-6-activated Stat3 signaling regulates satellite cell behavior, promoting myogenic lineage progression through myogenic differentiation 1 (Myod1) regulation. Conditional ablation of Stat3 in Pax7-expressing satellite cells resulted in their increased expansion during regeneration, but compromised myogenic differentiation prevented the contribution of these cells to regenerating myofibers. In contrast, transient Stat3 inhibition promoted satellite cell expansion and enhanced tissue repair in both aged and dystrophic muscle. The effects of STAT3 inhibition on cell fate and proliferation were conserved in human myoblasts. The results of this study indicate that pharmacological manipulation of STAT3 activity can be used to counteract the functional exhaustion of satellite cells in pathological conditions, thereby maintaining the endogenous regenerative response and ameliorating muscle-wasting diseases.
STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Tierney MT, Aydogdu T, Sala D, et al. Nat Med. 2014 Sep 7. doi: 10.1038/nm.3656. [Epub ahead of print]
26/09/2014 - SUN1 and SUN2 variants in muscle disease pathogenesis
Proteins of the nuclear envelope (NE) are associated with a range of inherited disorders, most commonly involving muscular dystrophy and cardiomyopathy, as exemplified by Emery-Dreifuss muscular dystrophy (EDMD). EDMD is both genetically and phenotypically variable, and some evidence of modifier genes has been reported. Six genes have so far been linked to EDMD, four encoding proteins associated with the LINC complex that connects the nucleus to the cytoskeleton. However, 50% of patients have no identifiable mutations in these genes. Using a candidate approach, the authors of this study have identified putative disease-causing variants in the SUN1 and SUN2 genes, also encoding LINC complex components, in patients with EDMD and related myopathies. The data also suggest that SUN1 and SUN2 can act as disease modifier genes in individuals with co-segregating mutations in other EDMD genes. Five SUN1/SUN2 variants examined impaired rearward nuclear repositioning in fibroblasts, confirming defective LINC complex function in nuclear-cytoskeletal coupling. Furthermore, myotubes from a patient carrying compound heterozygous SUN1 mutations displayed gross defects in myonuclear organization. This was accompanied by loss of recruitment of centrosomal marker, pericentrin, to the NE and impaired microtubule nucleation at the NE, events that are required for correct myonuclear arrangement. These defects were recapitulated in C2C12 myotubes expressing exogenous SUN1 variants, demonstrating a direct link between SUN1 mutation and impairment of nuclear-microtubule coupling and myonuclear positioning. These findings strongly support an important role for SUN1 and SUN2 in muscle disease pathogenesis and support the hypothesis that defects in the LINC complex contribute to disease pathology through disruption of nuclear-microtubule association, resulting in defective myonuclear positioning.
>Full text
Muscular Dystrophy-Associated SUN1 and SUN2 Variants Disrupt Nuclear-Cytoskeletal Connections and Myonuclear Organization. Meinke P, Mattioli E, Haque F, et al. PLoS Genet. 2014 Sep 11;10(9):e1004605
26/09/2014 - The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy
The integrity of the plasma membrane is maintained through an active repair process, especially in skeletal and cardiac muscle cells, in which contraction-induced mechanical damage frequently occurs in vivo. Muscular dystrophies (MDs) are a group of muscle diseases characterized by skeletal muscle wasting and weakness. An important cause of this group of diseases is defective repair of sarcolemmal injuries, which normally requires Ca2+ sensor proteins and Ca2+-dependent delivery of intracellular vesicles to the sites of injury. MCOLN1 (also known as TRPML1, ML1) is an endosomal and lysosomal Ca2+ channel whose human mutations cause mucolipidosis IV (ML4), a neurodegenerative disease with motor disabilities. This study reports that ML1-null mice develop a primary, early-onset MD independent of neural degeneration. Although the dystrophin-glycoprotein complex and the known membrane repair proteins are expressed normally, membrane resealing was defective in ML1-null muscle fibers and also upon acute and pharmacological inhibition of ML1 channel activity or vesicular Ca2+ release. Injury facilitated the trafficking and exocytosis of vesicles by upmodulating ML1 channel activity. In the dystrophic mdx mouse model, overexpression of ML1 decreased muscle pathology. Collectively, these data have identified an intracellular Ca2+ channel that regulates membrane repair in skeletal muscle via Ca2+-dependent vesicle exocytosis.
The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy. Cheng X, Zhang X, Gao Q, Ali Samie M, et al. Nat Med. 2014 Sep 14. doi: 10.1038/nm.3611. [Epub ahead of print]
26/09/2014 - Identification of novel clinical phenotypes and unusual multisystemic presentations in a large cohort of myofibrillar myopathies
Myofibrillar myopathies (MFM) are a group of phenotypically and genetically heterogeneous neuromuscular disorders, which are characterized by protein aggregations in muscle fibres and can be associated with multisystemic involvement. Here, the authors screened a large cohort of 38 index patients with MFM for mutations in the nine thus far known causative genes using Sanger and next generation sequencing (NGS). They studied the clinical and histopathological characteristics in 38 index patients and five additional relatives (n = 43) and particularly focused on the associated multisystemic symptom. They identified 14 heterozygous mutations (diagnostic yield of 37%), among them the novel p.Pro209Gln mutation in the BAG3 gene, which was associated with onset in adulthood, a mild phenotype and an axonal sensorimotor polyneuropathy, in the absence of giant axons at the nerve biopsy. They revealed several novel clinical phenotypes and unusual multisystemic presentations with previously described mutations: hearing impairment with a FLNC mutation, dysphonia with a mutation in DES and the first patient with a FLNC mutation presenting respiratory insufficiency as the initial symptom. Moreover, they described for the first time respiratory insufficiency occurring in a patient with the p.Gly154Ser mutation in CRYAB. Interestingly, a polyneuropathy was detected in 28% of the MFM patients, including a BAG3 and a MYOT case, and hearing impairment in 13%, including one patient with a FLNC mutation and two with mutations in the DES gene. In four index patients with a mutation in one of the MFM genes, typical histological findings were only identified at the ultrastructural level (29%). The authors conclude that extraskeletal symptoms frequently occur in MFM, particularly cardiac and respiratory involvement, polyneuropathy and/or deafness. BAG3 mutations should be considered even in cases with a mild phenotype or an adult onset. A genetic defect in one of the known genes was identified in less than half of the MFM patients, indicating that more causative genes are still to be found. Next generation sequencing techniques should be helpful in achieving this aim.
>Full text
Unusual multisystemic involvement and a novel BAG3 mutation revealed by NGS screening in a large cohort of myofibrillar myopathies. Semmler AL, Sacconi S, Bach J, et al. Orphanet J Rare Dis. 2014 Aug 1;9(1):121.
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(CLOSED)1500 Points Raffle(CLOSED) 1500 Points raffle :iconsealglompplz:How to join just fave this journal The raffle will end in 3 daysgoodluck :iconkissingplz:
[CLOSED+WINNER] Adopt Raffle 09 - MemoriesHi \;///v///;/ Thanks again for the support T////T I receive so many comments ;__; all so kind T////Tnnngh you have so wonderful idea for them ;__;Forgive again for the late Now I have the winner of the raffle \;//v//;/ <3 <3 <3This is :iconAzaikar: waaaah I'm so happy for you T////v////T <3 <3 <3 \;//v//;/Now Azaikar can choose her favorite in the batch and the others will be put on sale \;//v//;/ ( I'll make a poll before sell them ;u; <3 <3 )THANKS A LOT AGAIN TO EVERYONE *cries* ç__ç I feel very happy T////T <3 <3 <3HAVE A WONDERFUL DAY SEE YOU SOON IN THE NEXT RAFFLE Feel free to remove the journal from fav if you wish Waaah such a long time we didn't make a raffle >///v///< We really love doing that so this time we try with our new project "Memories" , Little Owl/penguin ( x°D )We hope you like them \;///v///;/
How to Spot a Fake ApologyDid you know that I know how to spot a fake apology? It's actually kind of like a super power of mine. But more to the point, a lot of people who get blocked on any of my various social media sites want to get around their blocking just to do whatever the hell they did to get them blocked, but some of them are genuinely repentant. How do you spot the difference, because to tell you the truth, it's not always easy. I'm going to go more into detail about this in Brian's a Bad Father because it has some of the worst, most half-assed non apologies that I've ever seen. Well mostly. Reality is stranger than fiction. But I'm going to use that episode as some of these examples, along with things that people have actually tried to say to me to pretty much do the same shit again.How many first person pronouns do they use?This is the rule of thumb. If there's a first person pronoun that doesn't involve "I'm sorry" or "I messed up pretty bad" or something along those lines, it
1000 Points Giveaway! 1000 Raffle How to enter? All you have to do is this journal. Winners? 1st random - 5002nd random - 2503rd random - 250 The random winners will be picked using the random.org sites "True Random Number Generator" to pick the lucky winners from the favourited list.Closes on 21st of September.Good luck to you all!
2500 Point Giveaway [OPEN] #5Hi guys! Just for anyone interested and/or that is really needed points, simply follow info.*and if you want help, please contribute a small or big donation, would be a great value! ♥ Enter in my profile page: ~~Help-donate-points~~ ---------- ----------I would like to thank the support of&
Regarding Recent EventsHey everyone.Unfortunately, today's journal isn't a cheery one. For those of you who are active on tumblr, I'm sure you're already aware. But I'm also sure that there are still some of you who have not yet been informed. Comickit, whom I'm sure you know as the artist of "Pasta Monsters", recently released her statement on the abuse she suffered at the hands of Snuffbomb during their time dating one another.http://comickit.tumblr.com/post/97829561023/why-your-date-with-snuffbomb-was-badThis act of bravery sparked countless others to step forward with accounts of unspeakable abuse ranging from emotional to physical and straight up sexual assault. Due to the overwhelming number of people that have stepped forward, an entire page has been made to document them all.http://snuffbomb-victim-awareness.tumblr.com/Now, as I'm sure you all clearly remember, I personally went through a rough patch with Snuffbomb myself not too long ago. The result was my removing him from the cast of "T
Your character in Missing Halloween! (RESULTS)MISSING HALLOWEENINTRODUCTIONIn August 21, "Your character in Missing Halloween!" mini-contest was announce.In September 1, a total of 313 character designs were submitted. Judging has begun.As the judge, there were 313 submissions, and only 32 to choose from. Trust me, it was haaaarrd! It still pains me that so many great designs didn't get in. (It's just that many) But I still did my best to judge them carefully.So here goes, the results!!!THE TOP 5 CANDY GIVERSAs mentioned, there will be 5 characters who will be featured as candy givers! (And their owners to be in the credits as "Additional Character Design")And here they are!!!:iconAndrea4You: Andrea4You's character: Akai:iconSkunkyfly: Skunkyfly's character: Amber:iconShiroXIX: ShiroXIX's character: Pydur:iconinkstainkat15: :d
[Giveaway] 400 WATCHERS / 14 500 PAGEVIEWSGuys, you're the best.I can't believe this; 400 watchers? AND 14 500 PAGEVIEWS? ...That's a lot of attention for a simple 14-years-old school girl like me. So I decided to make my first Giveaway! GIVEAWAY This is the 400th watcher milestone. The 1st place will win 700 The 2nd place will win 300 The 3nd place will win 150 The winners will be chosen via random. The deadline is the 28th of September 2014, Midnight GMT.
200 Point Giveaway~:iconpumkinplz::iconstardividerplzL::iconstardividerplzM::iconstardividerplzR::iconstardividerplzL::iconstardividerplzM::iconstardividerplzR::iconstardividerplzL::iconstardividerplzM::iconstardividerplzR::iconpumkinplz:There will be Three Winners.First place will get 100 Second will get 50 Third will get 50 You must Favorite this Journal and Watch me to enter.The Date the winners are announced is October 1st:iconpumkinplz::iconstardividerplzL::iconstardividerplzM::iconstardividerplzR::iconstardividerplzL::iconstardividerplzM::iconstardividerplzR::iconstardividerplzL::iconstardividerplzM::iconstardividerplzR::iconpumkinplz:I will be using Random.orgHow does this work? See the thing on the Side that shows a list of who Favorited the Journal? Next to the names there are Numbers.Random.org randomly picks Numbers, So the Person with tha
The SecretCan You Keep A Secret?Well, me too, haha! But seriously, how often did you answer to the question if you can keep a secret with "no"? Probably much less often than with "sure" or "of course!" We don't want to appear being not trustworthy, and of course we are curious as well.But how often do we wish we hadn't heard what was just confessed to us, now we carry the burden of this knowledge with the promise not to share it with anybody else. What have we gotten ourselves into?And how often do we actually hold on to that secret indefinitely? Aren't we glad when we find out a secret is no longer a secret and we can finally talk about it, even feel a sense of bragging rights because we have been "in the know?"So I ask you again, can you keep a secret?IngoPS: thanks again for all the nice comments in last week's journal!
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"When you start a game, how do you get into the mood of concentrating from move 1?"
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As we all know, playing over-the-board chess has its own set of rules and guidelines that must be followed in tournament play. Breac... | Read More
In the first part of this article, we left our Chess Terminator playing countless blitz and bullet games during the last free day of the championship. In the following seventh round, Nakamura had a very tough opponent.
By the way, this is a good... | Read More
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Once the clock started, the Tournament Director (TD) said "in order to claim a Win against a 'No-Show,' your clock must run for (1) hour without him or her ever showing up... and it did..."
Final Game 0F-1F
Final Score 3-3/6
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The Manhattan Applesauce are off to a strong start to the season and remain one of the three perfect teams after two weeks of play. The 'Sauce will look to continue their winning ways against the St. Louis Arch Bishops in our W... | Read More
In the first round of the Chess Masters Final, Viswanathan Anand immediately grabbed the lead. In the clash between ex-World Champions, Anand defeated Ruslan Ponomariov after 61 moves in a King's Indian game. Francisco Vallejo Pons and Levon... | Read More
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Is it a perfect start? Mathematically, yes.
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"... | Read More
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This isn't just any old Death Match conclusion. Watch and see the streak that Meier goes on to even the score and then overtake Balog with only seconds remaining on the match clock. But he won too quickly, allow one last bullet game! Balog converts his opportunity, sending the match into sudden-death overtime! It was a wild final game for all the glory. Watch and you'll also hear how oblivious the players were to the situation - genius and comedy in Death Match 21! | Watch video
Things are getting very interesting in the 3+1 segment, as the underdog Balog simply will not relent. The two are playing almost the same setup every game, and Meier cannot seem to go on a run. Both are showing incredible blitz prowess and fantastic clock management, but someone is still going to trail going into the bullet portion! | Watch video
Grab a snack - we've got a long live session with IM Danny Rensch. Was he in the mood to accept the Smith-Morra Gambit today? And how can you help experts in the line like GM Lenderman and IM Esserman enlighten us more about the opening? Danny will let you know. You'll also see him try to draw blood from a stone. Can he swindle his lower-rated opponent as the clock ticks down? | Watch video
Today you'll see our regular video author GM Khachiyan have to beat a young IM about a half-dozen times. Equally important perhaps is seeing how Black makes life as difficult as possible for the GM. The tenacity leads to a worse, but still imbalanced and highly rare R+N+3P versus Q endgame. Who needs time-delay and increment when this kind of fun ensues with regular clocks? We guarantee you'll learn more than from the t.v. show "The O.C." | Watch video
In Part 6, FM Mike Klein was ahead a pawn and broke through on the opposite flank to create his second weakness. Today, he takes an equal position and attempts to win both sides of the board as well. Don't be afraid to transition into an endgame that you can't possibly lose, even if you're not sure you're winning. It's more technical than tactical, but so is the process of setting your chess clock! | Watch video
In chess, as in other games that promote gamesmanship, "The Stare" is a common tactic used by players to intimidate, annoy, confuse and otherwise put an opponant out of his or her comfort zone. It is generally done when a player is trying to thi...
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Curt von Bardeleben (1861-1924) was a German count and the strongest German player of the late 19th century, an openings expert, and player of Grandmaster strength. He studied law, but never practiced, preferring to play chess. He was German cha...
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Arnold Sheldon Denker (1914-2005 was a onetime boxer and boxing manager (won three successive Golden Gloves bouts by knockouts). He won the New York State championship in 1938 and 1939. He won the Manhattan Chess Club Championsh...
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He was one of the strongest players in the whole world...but little is know about his life. He was born in America (March,9 1943) and he quickly became the first American to win the official World Chess Championship. He was very very young when he...
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Bughouse (also reffered as tagteam and siamese chess) is played with two teams of two, using two sets. Each player on the team plays a different color than their partner. It begans as normal blitz chess, but every piece a player captures, he...
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In Defense of Women (Google eBook)
Arc Manor LLC, 2008 - Psychology - 120 pages
Please visit www.ArcManor.com for other great books.
What people are saying - Write a review
In Defense of WomenUser Review - Not Available - Book Verdict
Mencken's 1922 treatise contends that women are superior. Although told with his usual sarcasm, the book does hit on several real issues, such as employment discrimination, sexual harassment, and other double standards that still plague society. ... Read full review
Selected pages
Common terms and phrases
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Hacked By: selectLOL
Hack Information:
Hackbar: 1 Skip level.
Game Information
Laser beams, spikes, toxic waste and razor blades are just some of the hazards you will need to avoid in this action-packed plat former!
Cheats: Hackbar: Press [1] Toggle health - [2] Fast fire - [3] Fast ...
Hacked By: selectLOL
Cheats: Hackbar: Press [1] Toggle Health - [2] Toggle Gun Heat - [3]...
Hacked By: cilibiudragos
Cheats: Hackbar: Press [G] Toggle health - [H] Toggle energy - [J] T...
Hacked By: selectLOL
Cheats: Keyhacks: Press [1] Toggle godmode - [2]...
Hacked By: selectLOL
awsome starting music
This is pretty lame. This game is so tedious, it brings nothing new to the table and the design is really poor. Feels like someone pumped this out in a night
who here like the not doppler song!
Wth!!! when he dies its like he farts so hard he explodes. da sound makes it sound like it 2.
we should just be happy we have people to ack 4 us otherwise we would get very discouraged if we cant beat games. beating dem raises our self esteem . i saw this game on notdoppler
Registered Users: 423175
Hacks Played Today: 79392
Total Hacks Played: 619468576
There are 1643 users online
18 Members, 1625 Guests


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- »
Star-Spangled Spectacular (Sailabration)
September 10th - 16th
The commemoration of the War of 1812 Bicentennial concludes in 2014 with live entertainment, international tall ships and grey hulls, the Blue Angels, fireworks and other festive activities. More info can be found at www.starspangled200.com
Baltimore Book Festival
September 26th - 28th
The Baltimore Book Festival, the mid-Atlantic's premier celebration of the literary arts, features more than 200 authors, from award-winning children's writers and illustrators to celebrity chefs and bestselling novelists, as well as regional talent on several stages, book signings, comics, book arts, nearly 100 exhibitors and booksellers, children's activities, cooking demos, exhibitors, panel discussions, poetry readings, live music and an assortment of food, beer & wine. For more info www.baltimorebookfestival.org.


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3 ways to rock glittery makeup for Homecoming
What to do if you and your friend have the same crush
My boarding school roommate is driving me nuts
The 20 best teen books of all time
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The nail color were choosing all fall
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Ford Escape Questions Any type
- Newest
- Recently Active
- Unanswered
Rear Shock Towers And Rusted Inner Quarter Panels
just found this when went to do out of province insp /don't see//hear of any recalls but this is an ISSUE thats dangerous who else in Can/US been there
How Do I Turn On The 4 Wheel Drive In A 2009 Escape Xlt
I don't know how to turn on my four wheel drive in my 2009 escape xlt 4 wheel drive I don't have a drivers manual
05 Ford Escape Transmission Issues
My 05 Escape XLT 2WD will only move in drive 1 and reverse but this happened all of a sudden I can crank it and let it run to charge the battery and all and I move it around once in a while; but, no...
Why Won't. My Gearshift Not Engage Out Of Park.i Must Use A Screwdriver And...
2004 Escape, Both Headlights Went Out At The Same Time. High Break Works. T...
The Max Air Switch Does Not Change Any Thing When I Turn It On Except The I...
fan moter speed switch works fine for all 4 speeds
Transmission Just Like Stopped Working While I Was Driving Would Not Go Ove...
was driving out of no where it just revved up(the engine) but would not go then jumped and was going extreemly slow there is clean trans fluid does not look or smell burnt checked fluel filter and i...
I Have A 2011 Ford Escape The Transmission Seems To Hesitate Shifting Gears...
When It's Raining Hard, The Abs Light On The Instrument Panel Goes On. Als...
The ABS/AdvanceTrac lights go on when it's raining hard. The ABS light tends to stay on, the AdvanceTrac light may or may not stay on. Had trouble turning once, vehicle stuttered when trying to acce...
Why Wont My 2003 Ford Escape Back Up When It Is In Reverse And The Gas Peda...
I Have A 2002 Ford Escape That Keeps Looseing Power
it has a new battery the truck looses power only when u try to turn the key over then u have to disconnect the battery and re hook it back up to get power again the u loose it again when u turn the ke...
How To Use 4wd On 2014 Ford Escape
Can I Tow A 2009 Escape On A Truck Dolly If It Is In Neutral Behind A Rv
Towing behind a RV its a 2009 escape AWD 4X4 ON A Truck Dolly
How Can I Remove Gluey Mess Left After Fabric Door Inserts Have Fallen Off?...
All four fabric inserts fell off driver and passenger doors last summer. The plastic liner underneath isn't unattractive, but I'm having a difficult time removing the foam that was underneath. It had ...
Only My Rear Interior Dome Light Works When Doors Are Open ,switch Is In "d...
won't work with any door open ( back works fine ) ..front dome won't work with the dash switch either - but rear dome does work properly from dash switch
Where Are The Horns Located On A 2011 Ford Escape
Where are the horns located on my 2011 escape I have to replace them and I can't find them
How Do You Start A 2014 Escape If The Keyless Battery Is Dead
I've asked this question at two ford dealers, they cant seam to give me an answer. The keyless remote does have a key so that the door can be opened but how would you start the car?
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The #1 source for fashion inspiration from real people around the world.
HYPE the looks you like to make them hot —or post your own! learn more or sign up now!
by Elena M. · Mar 10, 2013
by Elena M. · Jan 9, 2013
girl from Austria
Fashion Blogger from Rio Branco - Brazil


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NASA image: Silver Fire, New Mexico
The Silver Fire in southern New Mexico continues to generate a lot of smoke, as seen recently on imagery from NASA's Terra satellite.
The Silver Fire in southern New Mexico continues to generate a lot of smoke, as seen recently on imagery from NASA's Terra satellite.
(Phys.org) —Data harvested from the sky may give researchers a view into the future of food production while opening insights to the implications of climate change.
NASA has delayed the launch of a sun-observing satellite by a day so that technicians can restore power to launch range equipment.
On June 19, 2013, the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Aqua satellite captured this image of smoke from wildfires burning in western Alaska.
On June 12, 2013, the Moderate Resolution Imaging Spectroradiometer (MODIS) on NASA's Aqua satellite captured this image of the Silver fire burning east of Silver City, New Mexico. In addition to producing ...
System 91W appears ripe to become Tropical Depression 4 in the next couple of days as it continues moving north and parallels the east coast of the Philippines. NASA's Aqua satellite captured a visible image ...
Tropical Storm Yagi is not expected to make landfall in Japan, but NASA satellite imagery showed that the storm was just south of the big island.
(Phys.org) —A NASA team delivered in May a sophisticated microwave radiometer specifically designed to overcome the pitfalls that have plagued similar Earth-observing instruments in the past.
From its orbit around the Earth, the NASA-NOAA Suomi National Polar-orbiting Partnership satellite or Suomi NPP satellite, captured a night-time image of California's Powerhouse Fire.
NASA's Aqua satellite captured an image of a large light-brown colored plumes of smoke from two large fires burning in New Mexico: the Thompson Ridge Fire (left) and the Tres Lagunas Fire (right).
NASA transferred operational control Thursday of the Landsat 8 satellite to the U.S. Geological Survey (USGS) in a ceremony in Sioux Falls, S.D.
Tropical Storm Barbara strengthened into a hurricane just before it made landfall late on May 29, and after landfall it weakened into a tropical depression. NASA satellite imagery showed that cloud tops warmed ...
(Phys.org) —Nanosatellites now have their own mass transit to catch rides to space and perform experiments in microgravity. A new NASA-designed and developed satellite deployer, dubbed the Nano Launch Adapter ...
NASA's Tropical Rainfall Measuring Mission satellite known as TRMM measured Cyclone Mahasen's rainfall rates from space as it made landfall on May 16. Mahasen has since dissipated over eastern India.


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BRAZIL: AmBev posts strong EBITDA gain in Q3
The Brazilian drinks group, AmBev, has posted a 59.7% increase in EBITDA for the third quarter of the current fiscal year to R$622.3m. The company said its EBITDA margin was up 11.1 percentage points to 36.9%.
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- Treasury Wine Estates pulls plug on takeover talks
- Anheuser-Busch InBev shuts fourth Russian brewery
- Mallya stays chairman at Diageo's United Spirits
Market research


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McFadden runs all over Jets in Raiders' 34-24 win
The Tailback racked up 171 yards and two TDs as Oakland shredded Rex Ryan's defense and handed New York its first loss of season.
The Tailback racked up 171 yards and two TDs as Oakland shredded Rex Ryan's defense and handed New York its first loss of season.
USA TODAY NFL writer Jarrett Bell serves up big story lines and key matchups of Week 3.
Julius Peppers was ranked as the game's best defensive end by USA TODAY Sports Weekly's panel of NFL writers and editors.
For perhaps the first time since the lockout was imposed on March 12, a glimmer of NFL competition took place on a football field on Wednesday.
Richard Seymour is leading 33 of his Oakland teammates in workouts in suburban Atlanta
The Oakland Raiders promoted assistant Chuck Bresnahan to defensive coordinator Monday, just weeks after bringing him back for a second stint with the organization.
The Oakland Raiders, fresh off their first non-losing season since winning the AFC in 2002, are often criticized for their free-spending ways, especially when they seem to overpay their own players. They could care less about outside perception. "These are moves that protect our franchise and protect our team and put us in a position to move on," says senior executive John Herrera.
Keeping one All-Pro could mean losing another for the Raiders.
It appears Oakland could be taking a risk by potentially making Richard Seymour one of the NFL's highest-paid defensive players.
Michael Bush rushed for 137 yards and a touchdown and the short-handed Oakland Raiders beat playoff-bound Kansas City 31-10 Sunday to gain a unique NFL distinction.
Michael Vick marked another milestone during his NFL resurrection Tuesday.
Peyton Manning made sure the Indianapolis Colts came out ahead in a game it turned out they didn't need to win to stay in control of the AFC South race.
Jason Campbell threw a 73-yard touchdown pass to Marcel Reece and Jacoby Ford scored on a 71-yard run to help the Oakland Raiders overcome Tim Tebow's two long touchdowns in his first career start and beat the Denver Broncos 39-23 Sunday.
David Garrard threw three touchdown passes, Maurice Jones-Drew and Rashad Jennings each topped 100 yards rushing and the Jacksonville Jaguars beat the Oakland Raiders 38-31 Sunday in a game filled with big plays.
Look who's in first place? The St. Louis Rams. By withstanding a late Denver Broncos rally, coupled with a Seattle Seahawks loss, the Rams technically lead the NFC West.
On Tuesday night, Ward said on his WDVE radio show in Pittsburgh that Seymour would have been suspended if he had punched Colts QB Peyton Manning or Patriots QB Tom Brady.
Fines and flags, punches and puzzlement. The Pittsburgh Steelers have faced a number of potential distractions since linebacker James Harrison's helmet-to-helmet hit on Browns receiver Mohamed Massaquoi last month helped trigger the NFL's stricter stance against dangerous play. They've been fined multiple times, and flagged for a record amount of penalty yardage.
Pittsburgh Steelers coach Mike Tomlin chose to stay out of the fray when asked about the fine levied on Oakland Raiders DL Richard Seymour on Monday.
Next man up. That's the mantra that everyone can relate to in the NFL. "It sounds like a broken record," Indianapolis Colts safety Antoine Bethea said after Sunday's loss at New England. "But everyone here is capable of playing at a high level. So if somebody goes down, the next man up has to come in and play ball."
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Interactive insider: University of Arizona vs. Oklahoma State University (Alamo Bowl)
Check out who will take the field in the 2010 Valero Alamo Bowl in San Antonio on Wednesday.
December 27, 2010 4:22 pm • Kori Rumore / Arizona Daily Star
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The Santa M.D. Circus Trolley attraction, which recently celebrated its operational anniversary
Wedged comfortably into one of Santa M.D. Circus Trolley's clearly human-hostile animal transports, you'll go on a magical trip through Storybook Garden and get an overhead view of diminutive kit-based cartoon locations.
Ruin everything with Princess Mode
© copyright 2011–2014
A Pants Aflame production


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More Videos...
Royal Marine driver gets stuck
Ever tried driving a 50 ton truck up a muddy slope? This Bootneck did, and
needed rescuing.
Några korta klipp från Maskinskyddarnas nya film om Torvmaskiner. Läs
mer och köpr den på www.maskinskyddarna.nu
Russian Kamaz trucks in action at IDEX
Russian Kamaz trucks at Idex-2003 in the UAE. These trucks, along with
Czech Tatras are the best in the world.
6x6 wall climb weismannmarine
6x6 offroad vehicle diesel climb up a wall. 42hp Smart diesel. Weismann
differential with back to back tripod joints.
Lasso is the name of the Vehicle. It was a vehicle designed to fit into the
v-22 Osprey and carry a 2500lb payload. It has a 42hp Smart diesel engine
and 3 of our Locking differentials.
L.A.S.S.O "Land-Air-Sea-Special-Operations". It is managed by VSECORP.
A really awesome 12-wheeled train-like machine
Truck Truoble
some big cool truck , in big and kool truoble.
F250 Turbo Diesel with Monster Hooks rescues sinking Hummer with driver still in the car!
A Ford F250 turbo diesel rescues a
sinking Hummer from a mud pool with driver still inside.The F250 owner
pulls out a huge tow hook from Monster Hooks, a recovery strap, and get the
Hummer out. This video is DEFINITELY entertaining!
Torrelavega Truck festival 2011
70ton dumper stuck in mud pulled by D10 dozer
This CAT777 dumper got stuck in a soft muddy spot and it took a D10 dozer
as well as a big loader to get it out.
We loaded this dumper with single wheels at the rear because owner was
waiting for new tyres to be delivered.
To get to the offloading point we have to cross under a bridge which is too
low for us to pass under. We then offload before the bridge and the dumper
drives under the bridge by its own where we load it again further to
offloading point.
After passing under the bridge we got stuck in a soft muddy spot. Probably
would not have; if we had duals on the rear of the dumper.
Dumper is working on Coal mine in South Africa near Johannesburg.
driving out of a watery skid
driving out a watery skid Aaron is the cameraman
UAZ in deep snow.
It's not a usual car, it's not a truck, it's not a hummer - it's russian
four by four civillian multi pourpose vehicle. Great car for great
RÁBA H18 Military truck (Hungarian Army)
RÁBA H18 Military truck (Hungarian Army)
scammell constructor (old engine start) part 1
1958 scammell needing some serious work but check it out she's a runner.
холодный пуск К-700А /Cold start К-700А .wmv
-17 ни кокого прогрева, да-же воду залили
AEC Militant wheelying
AEC Militant Mk3 Recovery towing two Scammell Constructors. About 55 tons
all up.
The second Scammell has got his brakes on.
Lamborghini Huracan Driving Event and 60-130 MPH Testing
Ford GT McLaren MP4-12C Lamborghini Gallardo Super Trofeo Stradale Photo Gallery
GoPro Winner for August 2014 is Steve with a 2002 Dodge Dakota
Lamborghini Huracan vs Porsche 911 Turbo S PDK Racing
Which car is faster?
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2008 Infiniti G37 Sport - 5AT: 11.130 @ 123.930
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1973 Toyota Carina : 11.744 @ 114.790
Nick Martinez, Engine: 93 22RE, Turbos: T68
1973 Toyota Carina : 11.752 @ 116.980
Nick Martinez, Engine: toyota 22rte, Turbos: T-68 Tires: Micky
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John K, Engine: stock, Turbos: GTM stg2
2008 Infiniti G37 S GT28RS Turbo: 12.539 @ 116.710
Christian Guerrero, Engine: Stock 3.7 VVEL, Turbos: GT28RS .86 Tires: Stock
2000 BMW 328i Sedan Supercharged: 12.922 @ 108.970
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2013 Infiniti G37 : 13.090 @ 106.380
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2010 Infiniti G37 Base: 13.157 @ 105.700
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Kul S, Engine: 3.7L, Tires: Michelin Pilot Sport A/S Plus
2011 Infiniti G37 Sport: 13.660 @ 102.610
Terry, Engine: 3.7,
2008 Infiniti G37 non sport: 13.700 @ 101.290
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text:
CPU performance - PIII
Last response: in CPUs
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Stick or treat! Cute and creepy crafts for a haute Halloween
Do guys like girls that wear makeup?
Fem-men-ism: 'HeForShe' invites boys to fight like a girl
Check out these Disney stars' big girls day out (that included dress up and Star Wars)
Your weekly horoscope!
The shoe were loving for fall: loafers!
Your ultimate fall nail polish guide
5 fierce apps to help you get your fit on
What type of Halloween costume should you try this year?
Ever feel a little jealous? Spill for an upcoming issue of the mag!
Disney Channel "Choose Kindness" Campaign
More Friends = More Fun
GL Tweets !
AN HOUR AGO Do guys like girls who wear makeup? http://t.co/6KjYr0Sxnk
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I don't get it.
He says I don't have to
I should just tell him it's okay
I told him I didn't want to lie.
He stood up and put his hands on his hips
He walked in slow circles
Frustration showing in his tense fingers
He looked older than seventeen
I told him that.
He laughed
I love when he laughs
I'll miss that
He sat back down on the bed
And put his head in his hands
I couldn't help asking why
He said 'cause it wasn't fair
They shouldn't be able to get away with what they did
And he thought he would look nice in uniform
That made me laugh
I wish it hadn't.
'Cause he thought that made it okay
He hit my shoulder like he always did
I'd miss that too
I just didn't know why it had to be him
Why he had to fight for everyone here
When most of them didn't even know
The sacrifice he was making
The sacrifice I was making
Maybe that's why I was so pissed
'Cause he got to go off and do something great for our
And I was stuck here missing him.
Sorta worried for his life
Scared I might not see him again
Well alive anyway
Then I remembered he was there
Watching me
I hadn't cried about it yet
And I didn't plan on him seeing me finally start
But I guess I didn't plan on him joining the army either
And maybe that's why I just couldn't hold it in any longer
I looked down when my eyes started to water
He lifted my chin with one finger
And the tears spilled over
I think that spoke louder than any words I could say
So I got up
Went to my room
And sat with my back to the door
Until I heard him come sit on the other side
I don't know if he heard me whisper thanks
But he asked if he had told me yet
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Andrew Colley
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Andrew Colley LATEST
Student may have survived car crash if he was wearing seatbelt, inquest hears
8:00am Tuesday 16th September 2014
A STUDENT may have survived a car crash earlier this year had he been wearing a seatbelt, with Bucks drivers now being warned to buckle up.
Video: Crowds gather for Tour of Britain
11:00am Saturday 13th September 2014
CROWDS gathered in their hundreds in Princes Risborough yesterday as the Tour of Britain raced through Bucks.
Tour of Britain races through Bucks
11:52am Friday 12th September 2014
Follow our live coverage from 1pm as people line the streets in South Bucks ahead of the arrival of the Tour of Britain.
Family lead tributes to tragic teenager
10:00am Saturday 13th September 2014
THE family of a teenage motorcyclist who died in High Wycombe on Wednesday have led the tributes to him.
Details emerge after teen dies in motorbike collision
11:10am Friday 12th September 2014
A TEENAGER who died in High Wycombe this week was travelling home from work on a motorbike he had only recently started riding, when he was in collision with a car.
Tributes pour in for tragic teenager
5:20pm Thursday 11th September 2014
TRIBUTES have been paid to an 18-year-old motorcyclist who died in a car collision yesterday.
Teenager who died in motorbike collision named locally
3:37pm Thursday 11th September 2014
AN 18-year-old motorcyclist who died following a car collision in High Wycombe has been named locally.
Teenage motorcyclist killed in car collision
4:06pm Wednesday 10th September 2014
A TEENAGE motorcycle driver has died following a collision with a car in High Wycombe this morning.
Police confirm collision fatality
2:45pm Wednesday 10th September 2014
A PERSON has died following a collision in High Wycombe, police have said.
School plans to cut two year groups
3:40pm Wednesday 10th September 2014
A SCHOOL in Gerrards Cross will gradually phase out Year 7 and 8 over the next few years to enhance the education of children from the age of four to 11.
German culture growing in Bucks town
11:00am Wednesday 10th September 2014
A GERMAN enthused talk and coffee morning will be held this month to celebrate the two year anniversary of a social group of retired residents from Beaconsfield.
War heroes to be remembered in special talk
2:20pm Sunday 14th September 2014
WAR heroes from Beaconsfield will be remembered during a poignant talk open to the public, this month.
Lorry driver injured in M40 crash
1:00pm Tuesday 9th September 2014
A MALE lorry driver had to be released from his vehicle after an accident on the M40 this afternoon.
Pub in the spotlight after starting own TV channel
2:20pm Wednesday 10th September 2014
A PUB in Beaconsfield is in the spotlight as the landlady attempts to capture a new audience by starting their own television channel.
Supermarket applies to open 24 hours a day
8:00am Wednesday 10th September 2014
A SUPERMARKET in Beaconsfield has applied to open its doors to the public for 24 hours a day, throughout the week.
Residents take to the stage for charity festival
11:00am Friday 12th September 2014
A POPULAR charity music festival will return to Beaconsfield this evening with a sporting husband and wife set to open the three-day event.
Community race returns to village
4:00pm Tuesday 9th September 2014
A COMMUNITY race, which has helped develop sports facilities in Wooburn Green by raising more than £15,000 since it began, will return to the village this weekend.
Pensioner felt threatened after housing benefit suspension
6:00am Wednesday 10th September 2014
A PENSIONER said he felt threatened after he received a letter from Wycombe District Council stating his housing benefit of over £115 a week could be suspended after a change in his circumstances.
Child suffers minor burns in kitchen fire
10:07am Tuesday 9th September 2014
A CHILD suffered minor burns after a kitchen fire in High Wycombe, yesterday.
Rescue dog becomes show winner
10:00am Tuesday 9th September 2014
A PET dog, which was rescued by the RSPCA as a puppy, has been nurtured and trained into a show winner, after his owners gave him a home, after seeing an advert in the Bucks Free Press.
Mum to have hair shaved in memory of teenage son
1:00pm Thursday 4th September 2014
A MUM, who has helped raise more than £175,000 for charity after her teenage son died of a rare tumour seven years ago, will shave her hair off today, on the anniversary of his death.
Charity raises £6,000 in memory of 'inspirational' boy
4:00pm Thursday 4th September 2014
AN 'inspirational' young boy who died earlier this year after being diagnosed with a brain tumour, always wanted to help others, his family said after they started a charity in his honour.
Award winning volunteers celebrate new minibus
11:30am Wednesday 3rd September 2014
AWARD-WINNING volunteers will celebrate the arrival of a new community minibus next week, and they hope their purchase will continue to support residents in the Wye Valley.
Injured soldier looks to future after two years of rehabilitation
4:00pm Wednesday 3rd September 2014
A BRITISH troop who was severely injured by a bomb while in action in Afghanistan, has set-up a new fitness group in south Bucks after recovering from his injuries.
Event for all the family in Gerrards Cross
3:50pm Tuesday 2nd September 2014
A BABY, toddler and family fair will be held in Gerrards Cross this month.
WWI hero to be honoured with second commemoration event
4:20pm Tuesday 2nd September 2014
A WAR hero, who lived in Beaconsfield from a young age, will be honoured in a special ceremony later this year, after the town's mayor visited his birthplace.
Craft show for youngsters at village library
10:00am Wednesday 3rd September 2014
A CRAFT show for children and teenagers will give youngsters a chance to win arty prizes, next month.
Bell ringers celebrate landmark anniversary
2:00pm Wednesday 3rd September 2014
FOR almost 200 years the sound of music could be heard across the Wye Valley, with bell ringing still proving popular today.
Sensory learning shop to raise money for charity
3:00pm Tuesday 2nd September 2014
A SENSORY learning shop in Flackwell Heath will host a charity ball next month to help raise money for charity.
More money needed to complete playground work
10:00am Tuesday 2nd September 2014
A FURTHER £40,000 is needed to be raised for Chepping Wycombe Parish Council to complete work on new playground equipment in Flackwell Heath.
Singing stars are gearing up for Knotfest
1:00pm Wednesday 3rd September 2014
KNOTFEST charity music festival, in Beaconsfield, will see a whole host of south Bucks singing stars take to the microphone.
The Bat and Ball, Holmer Green
10:00am Friday 5th September 2014
Family shop sparkles in Beaconsfield
4:05pm Monday 1st September 2014
A FAMILY-run business in Beaconsfield, hopes to sparkle for years to come after they opened a new jewellery shop just feet away from their other store.
Video: Gravity Grand Prix rolls back into town
6:00am Monday 1st September 2014
CARS and drivers of all different shapes and sizes roared down the quiet roads of Cookham Dean yesterday as the annual Gravity Grand Prix returned.
Heroes help injured troop start fitness group
8:00am Monday 1st September 2014
A BRITISH troop who was injured by a road side bomb while in action, has set –up a new fitness group in Gerrards Cross and Beaconsfield.
Sporting couple to open charity festival
4:47pm Saturday 30th August 2014
SPORTING husband and wife team Gabby and Kenny Logan will open this year's Knotfest Charity Music Festival.
Distraught family of teenager killed abroad 'had no support'
9:00am Sunday 31st August 2014
DISTRAUGHT relatives and friends of a teenager, who was killed on his first holiday abroad without his parents, have set up a witness appeal after they said the authorities offered no support.
Dispute over Hazlemere pavilion rumbles on
2:40pm Saturday 30th August 2014
A DISPUTE between Hazlemere Parish Council and a volunteer group has erupted after the council chairman suggested the group had been creaming off the profits of the village pavilion.
Residents challenge council over playground refurbishment
8:00am Saturday 30th August 2014
ANGRY residents say they intend to fight a parish council if rumoured plans to move a children's playground and build a new skate park are approved.
Council accused of being 'mean spirited' after toilets closed for fayre
3:00pm Friday 29th August 2014
A TOWN council has been accused of being 'mean spirited' after it was decided public toilets in Beaconsfield Old Town should be kept closed during the Country Fayre.
Mixed reaction to Terriers Farm development
5:00pm Saturday 30th August 2014
A POTENTIAL development of 400 homes on a farm in High Wycombe has received mixed reactions from residents who fought the last threat to the land seven year ago.
Councillors concerned about junction 3a plans
12:00pm Friday 29th August 2014
CONCERNED councillors have spoken out about a proposal to build a motorway junction in Flackwell Heath, and they now hope to put the brakes on any future development.
MP misses out on Ice Bucket Challenge
4:40pm Wednesday 27th August 2014
THE MP for Wycombe missed out on the Ice Bucket Challenge last week after a Bucks Free Press reporter sent a nomination his way.
Campaigners want consideration over strong development opinions
4:10pm Wednesday 27th August 2014
A CAMPAIGN group who have attempted to stop the Slate Meadow reserve site being released for development hope the strength of feeling against plans will be taken into account.
Family Announcement: Baby Sofia Torti
3:00pm Sunday 31st August 2014
THE first baby of a new family often brings surprises, but for the Torti family their baby girl was expected to be a baby boy.
New addition to Bourne End Marina
10:06am Wednesday 27th August 2014
A NEW restaurant and wine bar will be added to the landscape of the Bourne End Marina this year.
Early Christmas present for south Bucks shoppers
2:00pm Wednesday 27th August 2014
SHOPPERS will be given an early Christmas present this year with two free days parking being allowed in South Bucks this December.
Anger over plans for 22 homes to be built on old railway line
8:00am Wednesday 27th August 2014
CONCERNED residents have reacted angrily to plans which could see 22 homes built on the former railway line linking Bourne End to High Wycombe.
New youth club could stop anti-social behaviour in village
4:10pm Tuesday 26th August 2014
A FACILITY for children and teenagers in Flackwell Heath has been proposed to villagers.
Comedian: Stalking Danny Dyer resulted in new stand up tour
3:00pm Tuesday 26th August 2014
AFTER confessing his love for Danny Dyer and British crime culture during a train journey, a comedian who used to live in High Wycombe will not be pulling any punches with his new action packed stand up tour.


text:
Sri Lanka to establish 25 University Colleges for vocational technology
Sat, Jan 26, 2013, 12:15 pm SL Time, ColomboPage News Desk, Sri Lanka.
Jan 26, Colombo: Sri Lanka's Ministry of Youth Affairs and Skills Development plans to set up 25 university colleges affiliated to the University of Vocational Technology (UNIVOTEC) to create alternate learning pathways up to the degree level for students who are leaving formal education.
The government will set up 20 university colleges by upgrading the existing training centers falling under the purview of the Ministry. The government has allocated Rs. 1.6 billion in the 2013 Budget for the project.
Another 5 university colleges will be established in collaboration with the private sector.
The Cabinet approved the proposal made by Minister of Youth Affairs and Skills Development Dullas Alahapperuma to set up the university colleges.
The UNIVOTEC, established in 2009, provides a career path to obtain a degree for the students in the Technical Education and Vocational Training System, based on their aptitudes and abilities, to acquire University Education.
ColomboPage - Recent 10 Stories
Major Tamil party affirms self-rule within a unitary state in Sri Lanka-- [2 hours ago]
Sri Lanka expresses concern about the increasing use of armed drones in counterterrorism -- [2 hours ago]
Supporters of Sri Lanka opposition parties clash in Uva, journalist among injured-- [4 hours ago]
Sri Lanka's main opposition party to appoint Sajith Premadasa to Deputy Leader post tomorrow-- [5 hours ago]
Sri Lanka's Yal Devi train runs to Jaffna after 24 years-- [5 hours ago]
Sri Lanka to provide medical specialists to Maldives-- [6 hours ago]
UNP General Secretary Tissa Attanayake resigns from leadership council
US Trade Show 2014 to begin in Sri Lanka from September 29
Sri Lankan President is now electorally vulnerable - UNP
Sri Lanka Marxist party says it has come out of electoral 'recession'


text:
Gov. Bobby Jindal has held up Texas and Florida, states that do not levy income taxes, as models for luring investment and new businesses as he's made his preliminary case for abolishing Louisiana's own personal and corporate income taxes and making up the shortfall by upping the state sales tax. But as New Orleans non-profit journalism site The Lens points out, the two states are a poor model for emulation because they levy relatively high property and business taxes at the local level:
Citing LSU economist Jim Richardson, who was on the Public Affairs Research Council of Louisiana committee that studied the ramifications of Jindal's tax swap — Jindal has so far offered few details about his proposal — Louisiana under Jindal's plan doesn't have enough legs to stand on:
"Most states have a three-legged stool for raising revenue," said Jim Richardson, a Louisiana State University economist who co-chaired PAR's tax study. "Texas and Florida have two legs – sales and property – since they don't have an income tax." Under the Jindal plan, "Louisiana would have a one-and-a-half-legged stool – sales taxes and some local property taxes."
Read the full story here.
OCT 1 Bobby Jindal is sure doing his best to court the far right; this post on TIME magazine says he'll be over in Oklahoma today to stand beside the billionaires who own Hobby Lobby while they announce a Bible "museum." In Washington D.C. (Wonder if there will be an exhibit on Matthew 19:24?)
OCT 1 Blogger Ian McGibboney is taking a look at the penalty call that is causing a stir. During a Monday NFL game, a player for the Chiefs executed a Muslim prayer gesture following a touchdown. The NFL has announced that the call was wrong, but Ian's not so sure.
OCT 1 Here's a post on the Picayune's website that boils down the Saints' problems this season. It's an easy way for bandwagon jumpers to justify their fairweather support of the team.
OCT 1 Looks like hoards of whining college students and (extremely unflattering) satire can make a difference: The Advocate reports here that lease talks have reopened for Highland Coffees, a coffee shop near the north gates of LSU. Earlier this week, dismay was unleashed when the paper reported that the shop would be closing because its landlord had other plans for the space.
OCT 1 Blogger Mike Deshotels is outlining the flaws he sees in the so-called "Value Added Model" of teacher evaluation. It basically seeks to pay teachers according to how their students do on tests. (Sure hope they don't start using that model for doctors!) He's got a lot of information here, not just about the plan but about the people involved - and their history.
OCT 1 Columnist Jim Beam breaks down the difference between ISIS and ISIL, along with origins of each group and what has been reported about them over the years. It's a good clear primer if you're one of those continually confused by the names being thrown around.
OCT 1 Blogger Tom Aswell brings us up to date on the latest mess surrounding the Office of Group Benefits, which handles health insurance for state employees. It ain't pretty, and it has left Tom pleading for anyone who might be remotely competent in the Division of Administration to get in touch with him.
OCT 1 Look out! Some enterprising individual, who knows how to register a domain, has pulled off a stunning bit of hilarity here. Not long ago, blogger Lamar White Jr. gave us a post on Louisiana Family Forum, and how it is not a charity but is instead a tax shelter for a lobby. If you go to the interwebs and type in "louisianafamilyforum.com" you will find Lamar's story. Heh.
SEP 30 Here's another story that makes Louisiana look backward; blogger Manny Schewitz writes about a church that won't allow AA to use its facilities because those boozers might track in some gay. Every time he sees one of these, as he calls them "Whiskey Tango Foxtrot" type of stories, he always starts wishing: "Please don't let it be Louisiana... Please don't let it be Louisiana..."
SEP 30 This post on PoliticusUSA, an extremely liberal blog, takes aim at Bobby Jindal's disingenuous attempts to play both sides against the middle on the evolution/creationism issue. Jindal is "dutifully serving his Koch masters" on the climate change issue as well, blogger Rmuse writes.
SEP 30 Ever wonder what goes on in a football locker room following a game like Sunday's embarrassment? Here's a post on ESPN about the "reality check" the Saints had. Among the comments: "Right now we're not a very good football team."


text:
Hot Now
You can translate the lyrics into various languages.
User Panel
|Song Title
Public Enemy - They Call Me Flava Lyrics
Public Enemy – They Call Me Flava Lyrics
[Flavor Flav]
That's what I got everybody up in the Bronx sayin
(Get the fuck outta here)
Everybody up in the Bronx is sayin yooooooooooooooooooooo!
That's Flav shit nigga
[Chorus: x2]
They call me Flavor, Flavoristic majestic Flavor
Don't you know that I'm the Flavor that you gave-ah
I'm in the life that you live when you..
Ahh do it again [laughing]
[Flavor Flav]
Now they call me Flavor
I'm in the shot that you shoot when you swishin
I'm in your dip and your dive when you dippin
I'm the aroma in your motherfuckin kitchen (Now that shit's hot!)
Now they call me Flavor
I'm in your mouth when you wake up in the mornin (DAMN!)
I'm the stink on your breath when you yawnin (WHAT!)
I'm in the milk in the cows of the corn an'
Flavor Flav is the Flav, a mack
Flavor Flav will never stick you in your back
Flavor Flav is on the reel to reel
Flavor Flav is in what you feel, BOYEEE!
Now they call me Flavor
Flav will never stick you in your back
Flavor Flav is on the reel to reel, oh noooo!
Aiyyo {?} I don't know what the fuck I'm sayin
[Flavor Flav]
Get up get up get up and get down
Rock to the beat of a funky sound
Beat so sweet won't never go sour
Day by day every minute of the hour
The mornin hard eggs and tell me what's new
Got nuttin else to do but drink brew
Tryin to feel the flow, gettin so low
Standin there drinkin a quart of Old Gold
That's right, that's the way we gonna do it
And that's the way we gonna get through it
That's why I put my mind to it
And that's the way we gonna get through it [laughing]
South Freeport, break down
That's, where my families frown
After dark, Centennial Park
Go to Jones Beach, get on the back of a shark
[Flavor Flav: over Chorus]
But I ain't playin, you know what I mean?
Ohhh shit, one more time
[Flavor Flav]
If you really want it put I can put a nigga's light out
On the strength but I don't go that length
Cause, Flavor Flav don't live on that tip G
But don't get sleep on me
I get lurky boy
When you eat a beef jerky boy
Suey sauce and soy boy
I did it to 'em with Roy boy, whaaaaaaaaat?
[Flavor Flav: over Chorus]
C'mon, WHAT! Daaamn
C'mon, the rap Superman, CHAAAAAAAAAAARGE
[Flavor Flav]
Bring that beat back (hehehehe)
Bring that beat back (brrrrrrrr)
Bring that beat back [snickering]
Bring that beat back
Do you know what I ain't got time to waste on this shit all night
Fuck that, fuck that you know cause I got other shit to do
We gone!
[Public Enemy - They Call Me Flava Lyrics]
Lyrics powered by www.musiXmatch.com
Correct these Lyrics (if needed)
Listen To The Music Videos Of These Lyrics:
Lyrics Information
|Public Enemy Lyrics
|"Rebirth Of A Nation" (2006)
|Public Enemy Biography
Album Cover
Watch The Official Video
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text:
June 12, 2012
A coalition of higher education association presidents affirms the importance of undergraduate science, technology, engineering, and mathematics (STEM) education, particularly in the first two years of college.
The letter outlines a series of priorities and an action plan to promote broader alignment and deeper engagement among business, higher education, and government to increase overall STEM literacy and to improve undergraduate success in STEM fields; demonstrate the value of STEM academic study to many rewarding career pathways; and convey to students the skills and competencies required for the 21st century STEM workforce.
Supporting STEM Education
September 30, 2014
In today's headlines, University of California President Janet Napolitano writes about her freshman year at the helm in an Inside Higher Ed piece. In other news, Diverse: Issues in Higher Education carries the news that Wilberforce University has named veteran educator Algeania Warren Freeman as its president and Bloomberg reports that a top Treasury Department official says student-loan debt growth may slow as the economy strengthens. See these and more stories below.
September 29, 2014
Hundreds of senior higher education leaders will be on hand for ACE's 97th Annual Meeting, scheduled for March 14-17, 2015, in Washington, DC, to discuss the changing landscape of higher education today.
September 24, 2014
The results will inform a new study to examine how legal challenges to race-conscious admissions have changed contemporary admissions practices.
ACE and four other higher education associations have submitted comments on updating a 2011 Obama administration policy document, A Strategy for American Innovation.
Four-year historically black colleges and universities, minority-serving institutions and Hispanic-serving institutions can apply now to participate in a second round of the Change and Innovation Lab.


text:
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Cybernetics News
Underwater robot for port security (9/30/2014)
Football-size robot can skim discreetly along a ship's hull to seek hollow compartments concealing contraband. ...> Full Article
Soft robotics 'toolkit' features everything a robot-maker needs (9/29/2014)
Biologist awarded NSF grant to study spinal cord circuits controlling limb movements (9/29/2014)
A University of Oklahoma biology professor will study multifunctional and specialized spinal cord nerve cells that control leg movements with a National Science Foundation grant in the amount of $680,000 for the four-year project. ...> Full Article
Can cartoons be used to teach machines to understand the visual world? (9/29/2014)
Blood-cleansing biospleen device developed for sepsis therapy (9/17/2014)
Cutting the cord on soft robots (9/14/2014)
Engineers at Harvard's School for Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering have developed the world's first untethered soft robot -- and demonstrated that the quadruped, which can literally stand up and walk away from its designers, can walk through snow, fire and even be run over by a car. The hope is that such robots might one day serve as a search and rescue tool following disasters. ...> Full Article
Artificial membranes on silicon (9/13/2014)
Researchers advance artificial intelligence for player goal prediction in gaming (9/12/2014)
Researchers from North Carolina State University have developed artificial intelligence software that is significantly better than any previous technology at predicting what goal a player is trying to achieve in a video game. The advance holds promise for helping game developers design new ways of improving the gameplay experience for players. ...> Full Article
Soft robot squirms over fire, ice, and withstands crushing force (9/11/2014)
Engineers have created a shape-changing 'soft' robot that can tread over a variety of adverse environmental conditions including snow, puddles of water, flames and the crushing force of being run over by an automobile. The pneumatically powered, fully untethered robot was enabled by the careful selection of materials and composites, including silicone elastomer. It can carry its own weight and the authors say the robot demonstrates surprising resilience with implications for search and rescue missions. ...> Full Article
Researchers develop untethered, autonomous soft robot (9/6/2014)
Researchers demonstrate direct brain-to-brain communication in human subjects (9/5/2014)
In a first-of-its-kind study, an international team of neuroscientists and robotics engineers have demonstrated the viability of direct brain-to-brain communication in humans. ...> Full Article
Batteryless cardiac pacemaker is based on automatic wristwatch (9/4/2014)
A new batteryless cardiac pacemaker based on an automatic wristwatch and powered by heart motion was presented at ESC Congress 2014 today by Adrian Zurbuchen from Switzerland. The prototype device does not require battery replacement. ...> Full Article
Cellphone addiction 'an increasingly realistic possibility,' study finds (9/3/2014)
Women college students average 10 hours a day on their cellphones and men students spend nearly eight. Excessive use poses potential risks for academic performance, according to a Baylor University study on cellphone activity. ...> Full Article
Electric current to brain boosts memory (9/2/2014)
Stimulating a region in the brain via non-invasive delivery of electrical current using magnetic pulses, called Transcranial Magnetic Stimulation, improves memory. The discovery opens a new field of possibilities for treating memory impairments caused by conditions such as stroke, early-stage Alzheimer's disease, traumatic brain injury, cardiac arrest and the memory problems that occur in healthy aging. ...> Full Article
Sciatic nerve repair using adhesive bonding and a modified conduit (9/1/2014)
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receptionist jobs
Front Office Receptionist
Favorite Healthcare Staffing- Eugene, OR
Staffing is a Full Time Front Office Receptionist for one of our Lane County Medical Society member in Salem OR Temp to Perm M F Days 8am 5pm Skills and knowledge required:...20 days ago from CareerVitals.com Healthcare Job Board
Administrative Assistant/Receptionist
Search Group Partners- Salt Lake City, UT
is looking for an Administrative Assistant/Receptionist for our office in Salt Lake City, UT. Here are a few things you will likely find yourself doing in this role:...7 days ago from ZipRecruiter
Temp-To-Perm - Receptionist - Top NYC Financial Firm - 35K+B
Hunter Search Group- New York City, NY
Top NYC Financial Firm is seeking a Receptionist to support a small and rapidly growing office - This is an addition to staff - welcome all guests - answer all phone lines -...7 days ago from ZipRecruiter
Office Specialist 2 - (Receptionist)
State of Oregon- Salem, OR
DHS14-1248, JOB-SHARE DHS is about people. We help Oregonians be independent, healthy, and safe. We protect children who are abused or neglected. We provide treatment services to...5 days ago from GovernmentJobs.com
Receptionist / Data Entry
Clayton Services- Houston, TX
salary and full benefits. Job Description: Receptionist/Data Entry A major Manufacturing ... located in NW Houston is in need of a Receptionist/Data Entry Clerk (fluent in...13 days ago from ZipRecruiter
Receptionist/Administrative Assistant $55K
Green Key Resources- New York City, NY
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Temp Receptionist-Leading financial services provider-To $14/hrNEW
Beacon Hill Staffing Group- Boston, MA
Boston, is searching for a temporary receptionist. This person will maintain the front desk, handle phones, greet visitors, direct calls, receive & send packages and mail,...3 days ago from CareerBuilder
Medical Receptionist
Gnm- Santa Fe, NM
medicine office seeks an experienced Medical Receptionist with proven competency and success. Duties include: Day-to-day coordination of our clinical work. specifically: Welcoming...12 days ago from ZipRecruiter
Part Time Receptionist - Tallahasee
American International Group- Tallahassee, FL
close leads promptly. Act as a back-up receptionist for the Gainesville and Jacksonville, FL district offices. Perform other duties as assigned by management. High school diploma...5 days ago from IHispano
Temporary ReceptionistNEW
Spherion Staffing- Fargo, ND
resources can make! Job Description: Temp receptionist for the 2015 tax season (early December-April 15th) Job Duties: Answering phones Greet customers and walk-in traffic...5 hours ago from ZipRecruiter
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text:
So. I had a thought while reading Shatterglass today.
- Tris is described as having curly red hair that she braids and pins to her skull.
- At one point Keth notices that Tris did a good job with brushing Glaki's curls, better than Yali did (Though that was because Yali didn't have much time to spare on them).
- When Niko asks about Keth being Glaki's father, Tris says Glaki is "Tharian through and through". Tharians are described as having skintones all along the brown spectrum, and black curly hair.
Now, I always through it was odd that Tris wore her hair in braids along her head, almost like cornrows. I mean, it makes sense in context, but I thought it was interesting that those braids held. HOWEVER, with the mention of Tris attending to Glaki's hair well, and the general description of Tharians making them read as black to me, I've come to the conclusion that Tris is black.
So instead of headcanoning Tris as looking a bit like this:
I've started headcanoning her as looking more like this:
And will be drawing her accordingly.
(via minionier)