Prevention of Mental Health Disorders Using internet-and Mobile-Based interventions: A Narrative Review and Recommendations for Future Research
August 2017

Yasser Khazaal
Gianluca Castelnuovo
David Daniel Ebert firstname.lastname@example.com
David Daniel Ebert
Clinical Psychology and Psychotherapy
Friedrich-Alexander
University of Erlangen-Nürnberg
ErlangenGermany

Pim Cuijpers
Department of Clinical, Neuro and Developmental Psychology
Vrije Universiteit Amsterdam
AmsterdamNetherlands

Ricardo F Muñoz
Palo Alto University
Palo AltoCAUnited States

University of California
San FranciscoSan FranciscoCAUnited States

Harald Baumeister
Department of Clinical Psychology and Psychotherapy
University of Ulm
UlmGermany

Université de Genève
Switzerland

Università Cattolica del Sacro Cuore
Italy Katarzyna

Université de Genève
Switzerland

Prevention of Mental Health Disorders Using internet-and Mobile-Based interventions: A Narrative Review and Recommendations for Future Research

Article
81August 201710.3389/fpsyt.2017.00116Received: 21 September 2016 Accepted: 15 June 2017Review Frontiers in Psychiatry | www.frontiersin.org Edited by: Reviewed by: *Correspondence: Specialty section: This article was submitted to Public Mental Health, a section of the journal Frontiers in Psychiatry Citation: Ebert DD, Cuijpers P, Muñoz RF and Baumeister H (2017) Prevention of Mental Health Disorders Using Internet-and Mobile-Based Interventions: A Narrative Review and Recommendations for Future Research. Front. Psychiatry 8:116.mental healthself-helpe-healthm-Healthinternet interventionsdepressionanxietyprevention iNTRODUCTiON
Although psychological interventions might have a tremendous potential for the prevention of mental health disorders (MHD), their current impact on the reduction of disease burden is questionable. Possible reasons include that it is not practical to deliver those interventions to the community en masse due to limited health care resources and the limited availability of evidence-based interventions and clinicians in routine practice, especially in rural areas. Therefore, new approaches are needed to maximize the impact of psychological preventive interventions. Limitations of traditional prevention programs could potentially be overcome by providing Internet-and mobile-based interventions (IMIs). This relatively new medium for promoting mental health and preventing MHD introduces a fresh array of possibilities, including the provision of evidence-based psychological interventions that are free from the restraints of travel and time and allow reaching participants for whom traditional opportunities are not an option. This article provides an introduction to the subject and narratively reviews the available evidence for the effectiveness of IMIs with regard to the prevention of MHD onsets. The number of randomized controlled trials that have been conducted to date is very limited and so far it is not possible to draw definite conclusions about the potential of IMIs for the prevention of MHD for specific disorders. Only for the indicated prevention of depression there is consistent evidence across four different randomized trial trials. The only trial on the prevention of general anxiety did not result in positive findings in terms of eating disorders (EDs), effects were only found in post hoc subgroup analyses, indicating that it might be possible to prevent ED onset for subpopulations of people at risk of developing EDs. Future studies need to identify those subpopulations likely to profit from preventive. Disorders not examined so far include substance use disorders, bipolar disorders, stress-related disorders, phobic disorders and panic disorder, obsessive-compulsive disorder, impulse-control disorders, somatic symptom disorder, and insomnia. In summary, 2 Ebert et al. Preventing Mental Disorders Using the Internet Frontiers in Psychiatry | www.frontiersin.org August 2017 | Volume 8 | Article 116there is a need for more rigorously conducted large scale randomized controlled trials using standard clinical diagnostic instruments for the selection of participants without MHD at baseline and the assessment of MHD onset. Subsequently, we discuss future directions for the field in order to fully exploit the potential of IMI for the prevention of MHD.Mental health disorders (MHD) are highly prevalent, with estimated lifetime and 12 month-prevalence rates, ranging across countries between 18.1-36.1 and 9.8-19.1%, respectively (1). MHD are one of the leading causes of disability (2) and associated with an immense disease burden such as poorer quality of life of sufferers and their loved ones, an increased risk of developing chronic physical conditions and related mortality (3-5).The economic burden of these disorders is enormous, including substantial economic costs, reduced workforce participation, occupational impairment, and lost productivity (6-8).In the past decades, a variety of interventions have been developed to treat MHD for which efficacy has been demonstrated in a large number of randomized trials (9, 10). However, even assuming the hypothetical scenario of 100% coverage and compliance to evidence-based treatments, approximately only 28% of the disease burden attributable to MHD could be averted (11). In fact, less than half of the individuals with a MHD are recognized and treated (12). Therefore, attention has increasingly been focused on the prevention of MHD.Preventive interventions can be classified as universal interventions, directed at the whole population; selective interventions, directed at individuals with specific risk factors for the development of a MHD; or as indicated preventive interventions, directed at individuals in the prodromal stage of a disorder, who do not yet fulfill the criteria for a full blown disorder but experience subclinical symptoms (13).Emerging evidence indicates the potential of psychological interventions for the prevention of MHD. For example, in a recent meta-analysis, van Zoonen and colleagues found psychological interventions aiming to prevent major depressive disorders (MDDs) to reduce the incidence by approximately 22% (14). Results from another review found that cognitive behavioral indicated preventive interventions reduced the transition to psychosis with a risk ratio of 0.54 (95%-CI: 0.34-0.86) (15); encouraging evidence from a limited number of randomized controlled trials is also available, for example, for the prevention of eating disorders (EDs) (16) and tobacco use (17), whereas the efficacy for other disorders such as interventions to prevent anxiety(18)is not yet established.Although psychological interventions might have a tremendous potential for the prevention of MHD, their current impact on the reduction of disease burden is questionable. Possible reasons include that it is not practical to deliver those interventions to the community en masse due to limited health care resources and the limited availability of evidence-based interventions and clinicians in routine practice, especially in rural areas. Therefore, new approaches are needed to maximize the impact of psychological preventive interventions.Limitations of traditional prevention programs could potentially be overcome by providing Internet-and mobile-based interventions (IMIs). This relatively new medium for promoting mental health and preventing MHD introduces a fresh array of possibilities, including the provision of evidence-based psychological interventions that are free from the restraints of travel and time and allow reaching participants for whom traditional opportunities are not an option.Internet-and mobile-based interventions have been shown to be effective in clinical populations, including the treatment of depression (19-21), anxiety(20,22,23), alcohol use (24), and sleep disorders (25). However, evidence for their effectiveness in preventing the incidence of MHD is much less documented.This article provides an introduction to the subject and narratively reviews the available evidence for the effectiveness of IMIs with regard to the prevention of MHD onsets. Subsequently, we will offer some suggestions regarding the direction of future research in this field.CHARACTeRiZiNG iMisThe possibilities to use IMIs for the prevention of MHD range from mobile-based apps for the monitoring of health behavior and stand-alone self-help interventions to supplemental elements integrated in conventional on-site psychological interventions (blended concepts). One common element of such interventions is that emotional, cognitive, and behavioral processes are modified and their generalizations to users' daily lives promoted using established psychological techniques (26). IMIs can be categorized in regard to their use of technology, the extent of human support, the theoretical basis, and with respect to their areas of applications and indications(Figure 1).

Although psychological interventions might have a tremendous potential for the prevention of mental health disorders (MHD), their current impact on the reduction of disease burden is questionable. Possible reasons include that it is not practical to deliver those interventions to the community en masse due to limited health care resources and the limited availability of evidence-based interventions and clinicians in routine practice, especially in rural areas. Therefore, new approaches are needed to maximize the impact of psychological preventive interventions. Limitations of traditional prevention programs could potentially be overcome by providing Internet-and mobile-based interventions (IMIs). This relatively new medium for promoting mental health and preventing MHD introduces a fresh array of possibilities, including the provision of evidence-based psychological interventions that are free from the restraints of travel and time and allow reaching participants for whom traditional opportunities are not an option. This article provides an introduction to the subject and narratively reviews the available evidence for the effectiveness of IMIs with regard to the prevention of MHD onsets. The number of randomized controlled trials that have been conducted to date is very limited and so far it is not possible to draw definite conclusions about the potential of IMIs for the prevention of MHD for specific disorders. Only for the indicated prevention of depression there is consistent evidence across four different randomized trial trials. The only trial on the prevention of general anxiety did not result in positive findings in terms of eating disorders (EDs), effects were only found in post hoc subgroup analyses, indicating that it might be possible to prevent ED onset for subpopulations of people at risk of developing EDs. Future studies need to identify those subpopulations likely to profit from preventive. Disorders not examined so far include substance use disorders, bipolar disorders, stress-related disorders, phobic disorders and panic disorder, obsessive-compulsive disorder, impulse-control disorders, somatic symptom disorder, and insomnia. In summary, there is a need for more rigorously conducted large scale randomized controlled trials using standard clinical diagnostic instruments for the selection of participants without MHD at baseline and the assessment of MHD onset. Subsequently, we discuss future directions for the field in order to fully exploit the potential of IMI for the prevention of MHD. Keywords: mental health, self-help, e-health, m-Health, internet interventions, depression, anxiety, prevention iNTRODUCTiON Mental health disorders (MHD) are highly prevalent, with estimated lifetime and 12 month-prevalence rates, ranging across countries between 18.1-36.1 and 9.8-19.1%, respectively (1). MHD are one of the leading causes of disability (2) and associated with an immense disease burden such as poorer quality of life of sufferers and their loved ones, an increased risk of developing chronic physical conditions and related mortality (3)(4)(5). The economic burden of these disorders is enormous, including substantial economic costs, reduced workforce participation, occupational impairment, and lost productivity (6)(7)(8).

In the past decades, a variety of interventions have been developed to treat MHD for which efficacy has been demonstrated in a large number of randomized trials (9,10). However, even assuming the hypothetical scenario of 100% coverage and compliance to evidence-based treatments, approximately only 28% of the disease burden attributable to MHD could be averted (11). In fact, less than half of the individuals with a MHD are recognized and treated (12). Therefore, attention has increasingly been focused on the prevention of MHD.

Preventive interventions can be classified as universal interventions, directed at the whole population; selective interventions, directed at individuals with specific risk factors for the development of a MHD; or as indicated preventive interventions, directed at individuals in the prodromal stage of a disorder, who do not yet fulfill the criteria for a full blown disorder but experience subclinical symptoms (13).

Emerging evidence indicates the potential of psychological interventions for the prevention of MHD. For example, in a recent meta-analysis, van Zoonen and colleagues found psychological interventions aiming to prevent major depressive disorders (MDDs) to reduce the incidence by approximately 22% (14). Results from another review found that cognitive behavioral indicated preventive interventions reduced the transition to psychosis with a risk ratio of 0.54 (95%-CI: 0.34-0.86) (15); encouraging evidence from a limited number of randomized controlled trials is also available, for example, for the prevention of eating disorders (EDs) (16) and tobacco use (17), whereas the efficacy for other disorders such as interventions to prevent anxiety (18) is not yet established.

Although psychological interventions might have a tremendous potential for the prevention of MHD, their current impact on the reduction of disease burden is questionable. Possible reasons include that it is not practical to deliver those interventions to the community en masse due to limited health care resources and the limited availability of evidence-based interventions and clinicians in routine practice, especially in rural areas. Therefore, new approaches are needed to maximize the impact of psychological preventive interventions.

Limitations of traditional prevention programs could potentially be overcome by providing Internet-and mobile-based interventions (IMIs). This relatively new medium for promoting mental health and preventing MHD introduces a fresh array of possibilities, including the provision of evidence-based psychological interventions that are free from the restraints of travel and time and allow reaching participants for whom traditional opportunities are not an option.

Internet-and mobile-based interventions have been shown to be effective in clinical populations, including the treatment of depression (19)(20)(21), anxiety (20,22,23), alcohol use (24), and sleep disorders (25). However, evidence for their effectiveness in preventing the incidence of MHD is much less documented.

This article provides an introduction to the subject and narratively reviews the available evidence for the effectiveness of IMIs with regard to the prevention of MHD onsets. Subsequently, we will offer some suggestions regarding the direction of future research in this field.

CHARACTeRiZiNG iMis

The possibilities to use IMIs for the prevention of MHD range from mobile-based apps for the monitoring of health behavior and stand-alone self-help interventions to supplemental elements integrated in conventional on-site psychological interventions (blended concepts). One common element of such interventions is that emotional, cognitive, and behavioral processes are modified and their generalizations to users' daily lives promoted using established psychological techniques (26). IMIs can be categorized in regard to their use of technology, the extent of human support, the theoretical basis, and with respect to their areas of applications and indications (Figure 1).

Technical implementation

For the implementation of IMIs, numerous technical possibilities are applicable. These range from (1) the provision of evidencebased strategies as interactive self-help lessons; (2) e-mail, chat, or video-based sessions (27); (3) virtual reality for exposure interventions (28); (4) serious-games, in which psychological strategies are trained in the context of a computer game (29); (5) the use of automated memory, feedback, and reinforcement interventions, for example, through apps, e-mails, text messages, or short prompts, which support the participant in incorporating intervention content into everyday life; to (6) sensors and apps for monitoring health behavior such as physical activity, which can be used to support the learning process (30).

Theoretical Basis

Due to their distinctive structured nature, standardization, and focus on the training of strategies and specific behavior, IMIs are particularly suited for techniques that target changes in thoughts and behaviors (26). These include well-researched cognitive, behavioral, and interpersonal interventions. Approaches such as mindfulness-based methods, acceptance and commitment therapy, or psychodynamic approaches, which are already used within some clinical IMIs (31)(32)(33)(34)(35), also have the potential for application to preventive IMIs.

Human Support

As a basic principle, IMIs can be implemented with varying degrees of human support. The current most commonly used method is the so-called "guided self-help, " in which evidence-based content is usually provided as self-help material so that the participants can perform most tasks independently. An accompanying coach then regularly gives feedback on the completed exercises. Fostering adherence to the content of the intervention is usually the main aim of human support, rather than the delivery of new therapeutic techniques that go beyond the content of the current lesson (36,37). The main task of the coach is to clarify any comprehension questions, provide feedback on solved problems and progress, and to encourage participants to continue to work on themselves. For this to happen, communication can happen either synchronously (per chat or video) or asynchronously (for example, per e-mail), the latter of which is more commonly used, and normally takes a few minutes to a few hours (1-3 h) per participant and intervention. For the participant, the processing of self-help material, execution and repetition of exercises, as well as correspondence with a coach can, however, be very intense and require a much greater time investment than that of the supporting coach (38). The combination of self-help material with minimal human support via the Internet thereby increases empowerment of the participants and the degree of self-directed coping while maximizing the efficiency of the accompanying coach. Irrespective of location, asynchronous contact and timeindependent communication results in increased flexibility and autonomy for both participants and prevention workers.

An "Efficiency Model of Support" (39) has been recently put forward to contribute to the development of a taxonomy of elements involved in guided interventions, such as type, quantity, timing, quality, and cost of human support. A commentary on that article (40) suggests that it may be useful to categorize contemporary interventions into four major types: traditional face-to-face (FTF) interventions, FTF interventions augmented by behavior intervention technologies (BITs), BITs augmented by human support, and BITs that are fully automated.

Areas of Application

Applications of IMIs range from mental health promotion and mental disorder prevention to full treatment of mental disorders and interventions to reduce relapse or recurrence. In the fields of psychological health promotion and prevention, IMIs are considered a promising approach for increasing the accessibility of evidence-based psychological techniques to people on a larger scale due to their low threshold for accessibility, location and time independence, and anonymous usability (41). IMIs can be used in the prevention of mental disorders either as a stand-alone approach, as part of a stepped-care approach or as an integrated element of a preventive intervention consisting of online and conventional on-site sessions (blended).

As a stand-alone measure, IMIs increase the reach of effective psychological interventions. Telehealth interventions (live therapy online) can transcend space. IMIs can transcend space and time. For example, the temporal and spatial independence of IMIs facilitates access to evidence-based interventions for individuals with limited mobility or those who live in areas with low access to preventive interventions. Populations who are not able to attend appointments during usual visiting hours and, therefore, are not able to attend other on-site FTF options, would then also be able to participate in interventions in the evenings or on the weekend at their own pace. Persons who would have not sought to participate in a preventive intervention due to other individual reasons, such as fear of stigma, would also have access to IMIs. Despite increasing social acceptance of psychological interventions, everything that might be associated with mental problems produce for some individuals a sense of shame, which in itself creates a barrier to the actual use of preventive interventions (39,40). Moreover, a general problem with preventive interventions lies in the fact that, by definition, the impairment people appropriate for preventive interventions are experiencing is low or not noticeable to them, diminishing their willingness to "invest" into mental health interventions. Hence, the lower the threshold and effort associated with participating in a preventive intervention, the likelier it is that the target group makes actual use of it.

In the combination of IMIs and personal FTF interventions, the so-called Blended-Concept, IMIs take over areas that need not necessarily be mediated by a prevention worker, allowing more time during the sessions for FTF psychological process work (26). Prevention workers could, for example, delegate time-consuming routine aspects of the intervention, such as the delivery of psychoeducation to digital tools. In principle, IMIs could also be used to improve FTF interventions by providing exercises for the participant to work on in between the intervention sessions, thereby increasing intervention intensity. Another way in which IMIs could be used to improve the outcome of FTF interventions is by supporting the integration of behavior changes or training of techniques into routine life, thus extending the reach of the psychological intervention into the daily lives of participants. This can be achieved through methods, such as smartphone-based behavioral diaries, sending of messages with ultra-short prompts aimed at training-specific strategies in daily life, or smartphone-based coaches that lead patients through potential anxiety-provoking or other difficult situations.

Furthermore, the objective of most psychological interventions is that participants actively try to integrate new behavior into their daily life and maintain these changes in the long term. IMIs emphasize the active role of the person concerned in this process, thus promoting a sense of empowerment through encouraging them to use their own resources to solve problems. IMIs could be used by people much before there is any need to seek FTF mental health services (and hopefully prevent the need to do so), during times when they are receiving treatment, as adjuncts to FTF care, and after treatment ends, to maintain gains, continue to progress in terms of reaching ever sturdier mental health levels, and to reduce relapse and recurrence.

Within stepped-care approaches, the degree of support participants receive are designed according to their actual individual need. In step-up interventions (guided) preventive approaches can be offered, for example, to individuals in the prodromal disease stage (indicated prevention) as a first element in the chain of treatment in order to prevent the transition to the full blown disorder. Further intensive therapeutic support, such as outpatient psychotherapy, then occurs should the patient respond insufficiently to the self-help intervention. Similarly, step-down interventions supplement more intensive therapeutic measures with lower intensity support. For example, IMI-relapse prevention concepts could be offered to patients following an acute treatment in order to stabilize acute treatment effects and thereby prevent relapse and recurrence (42)(43)(44)(45)(46).

eFFeCTiveNeSS OF iMi iN PReveNTiNG THe ONSeT OF MHD

While there are currently well over 100 randomized controlled studies on Internet-and mobile-based concepts fostering mental health, only few studies to date have investigated their potential in preventing the incidence or onset of a MHD. In the following section, we will review these studies and thereby only focus on studies that assessed the effects of an IMI on MHD onset (assessed according to diagnostic and statistical manual of mental disorders/ICD criteria) in a sample of adults, adolescents, or children, who is free from an acute mental disorder at baseline. There are further studies on mental health IMIs evaluated in samples with subthreshold mental health conditions. However, these studies were often planned for other purposes than examining disorder onset and limited in their methodological quality (47). Table 1 gives an overview of the reviewed studies, and Tables 2 and 3 are about the characteristics of the reviewed studies and interventions.

indicated Prevention

Depression Three studies have evaluated the effects of Internet-based approaches with regard to the primary prevention of depression. Buntrock et al. recently published a trial on the effects of an Internet-based indicated prevention stand-alone intervention (41,48,60). They randomized 406 adults with subclinical symptoms of depression who did not fulfill the criteria for MDD in the last 6 months to either a 6-week guided Internet-based cognitive behavioral intervention or to an online passive psychoeducation intervention. The intervention group (IG) included behavioral activation and problem solving as core intervention components; in addition, participants were able to choose among several different optional modules (e.g., sleep hygiene/sleep restriction, progressive muscle relaxation, and rumination techniques). In addition to the Internet-based self-help module, a text message coach sent a set of "tiny tasks" to the participant's mobile phone in order to foster the application of intervention techniques in daily life. In the IG, 32% of the participants experienced a MDD during the 12 months of follow up, whereas 47% in the control group (CG) did. Cox regression analyses controlling for baseline depressive symptom severity showed a hazard ratio (HR) of 0.59 indicating a 41% reduction in the risk for developing a MDD with a number need to treat to avoid one new case of MDD of 5.9. It is important to note that, in this trial, it was not assessed whether participants had a prior history of MDD. Hence, future studies are needed to investigate whether the effects count both for first incidence and subsequent onset of MDD.

In a randomized crossover trial, Thompson and colleagues evaluated an 8-week Internet or telephone-delivered mindfulnessbased stand-alone intervention in 64 adult epilepsy patients with subthreshold depressive symptoms. They found that the incidence of MDD episodes, assessed via self-report from baseline to interim assessment was significantly lower in the intervention condition (0.0%) than in treatment as usual (TAU) (10.7%) condition 8 weeks following randomization. Half of the participants were assigned to receive the intervention via web, half via telephone, but the authors did not find any differences between the two different forms. Although future studies with longer follow-up periods, larger sample sizes and observer-based clinical interviews are clearly needed to determine the potential of the approach for the prevention of depression, this trial is an example of the potential of Internet-based approaches.

Imamura and colleagues (51) evaluated an Internet-based indicated prevention program with workers who self-identified as having depressive symptoms but not fulfilling the diagnostic criteria for MDD. They randomized 822 workers either to a 6-week, Internet-based cognitive behavioral program delivered in a comic-form or to a wait list CG. The CBT components of the program included self-monitoring, cognitive restructuring, assertiveness, problem-solving, and relaxation. Results showed significantly lower incidence of MDE at the 12-month follow-up, with 0.8 and 3.9% of the experimental and control participants, respectively, experiencing a MDE. This corresponds to a HR of 0.22 and a numbers needed to be treated of 32 in order to prevent one case of major depression. However, the results need to be interpreted with caution as the diagnosis of MDD had been established only on the basis of a self-report instrument [World Mental Health Composite International Diagnostic Interview (WHO-CIDI) self-administered] and not using standard clinician/expert-based diagnostic instruments.

Anxiety Disorders

The only trial we are aware of that evaluated the effects of an IMI on anxiety disorder onset is an indicated prevention of general anxiety disorder trial conducted by Christensen et al. (50). They evaluated three different versions of iChill, a 10-week Internetbased cognitive behavioral intervention for anxiety symptoms (without any reminders, phone reminders, and e-mail reminders) compared to two attention placebo CG (interactive, attentionmatched, Internet-based placebo control program "Healthwatch" with/without phone reminders) in 558 young adults (age [18][19][20][21][22][23][24][25][26][27][28][29][30] with general anxiety symptoms who did not meet the criteria for an anxiety disorder.

Generalized anxiety disorder onset at 6-month follow up was 6.7% across all IGs, and 4.5% across both CGs, a difference that was not statistically significant.

Selective Prevention

Depression

Christensen and colleagues evaluated the effects of a 6-week unguided fully automated Internet-based intervention for sleeping problems (SHUTi) with regard to the prevention of major depressive episodes (49,61). They randomized 1,149 adults with primary insomnia and depressive complaints who did not fulfill the criteria for a major depression to either SHUTi or to Healthwatch. Although large effects in the SHUTi group on insomnia complaints and a lower depression symptoms on the patient health questionnaire-9 at 6 weeks and 6 months compared with Healthwatch were found, the intervention was not superior with regard to the effect on diagnosis of MDD assessed with the Mini-International Neuropsychiatric Interview. However, only ~4% percent of the total sample developed a major depression during the 6-month follow up, making it difficult to detect any preventive effects, even at such a large sample size. Hence, future studies on the longer term follow-up data of this trial (12/18 months) are needed in order to conclude whether this approach is indeed promising with regard to the prevention of major depressive episodes.

Eating Disorders

At least two randomized trials have been conducted to date that focused on the selective prevention of ED onset. Taylor and colleagues evaluated the effects of an online cognitive behavioral selective preventive intervention (StudentBodies) on ED incidence compared with a wait list control condition over 3 years in a sample of women with a body mass index >24 and any baseline compensatory behaviors (53). Although they found     the intervention to be efficacious in reducing high weight/shape concerns over a period of 24 months and lower ED incidence rates in the intervention (5%) group compared to controls (10%), the difference in ED onset was only significant in a subgroup of individuals, recruited and treated at one particular trial site. However, they identified in subsequent analyses specific risk factors associated with ED onset [i.e., comments/teasing about eating from a teacher, coach, or sibling and lifetime depression (62)]. Based on these findings, they adapted the IMI to target these specific risk factors and subsequently evaluated this intervention (image and mood) in 185 young adult women (age 18-25) with elevated weight/body shape concerns, eating-related teasing, depression and compensatory behavior compared to a wait list-CG. Although ED onset rates within a 24-month follow up was 27% lower in the intervention compared to the CG, this did not reach the level of statistical significance. Significant lower onset rates were, however, found in a subgroup with the highest body shape concerns, onset (20 vs. 42%, number needed to treat = 5), indicating that it is possible to prevent EDs in very high-risk samples. Another study on StudentBodies showed promising effects on subthreshold ED onset, but did not investigate the effects on full blown disorder onset (63).

Universal Prevention

To the best of our knowledge, only one study has been published to date evaluating a universal prevention approach with regard to MHD onset. Lindenberg and Kordy (52) evaluated a universal approach for the prevention of EDs in secondary education students (age [13][14][15][16] with no prior ED diagnosis and not undergoing treatment for any ED. Young E[s]sprit is a stepped program tailored to the individual risk of the participant, with elements ranging from screening and tailored risk feedback plus recommendations for specific self-help modules, through monitoring of risk behavior and symptoms and synchronous group and individual online chats up to individual FTF counseling. Schools including a total of 1,667 adolescents were clusterrandomized in two waves to receive either Young E[s]sprit or an online-psychoeducation intervention. Results showed significantly reduced ED onset rates in the IG compared to control schools in the first wave (intervention: 5.6%, controls: 9.6%) but the second wave (intervention: 5.6%, controls: 4.8%) did not yield significant differences in the overall analyses.

Relapse Prevention

By now, quite a few studies have investigated the effects of IMI as a relapse prevention intervention (42-45, 64, 65), and at least two of these also investigated the effects of an IMI on the prevention of MHD relapse. Holländare and colleagues (55, 56) evaluated a 10-week guided self-help cognitive behavioral intervention for the prevention of relapse in 84 partially remitted depressed adults with at least one previous depressive episode in the past 5 years compared to a no-treatment CG. Six (intervention 5%, controls: 37.8%) and 24 months (intervention: 13.7%, controls: 60.9%) following randomization they found lower rates of relapse in the IG compared to the CG with a HR for time to relapse within 24 months of HR 0.16 in favor of the IG.

Bauer and colleagues (57) investigated the effects of a synchronous transdiagnostic non-manualized Internet-chat group as a stepped-care intervention following inpatient psychotherapy of MHD compared to TAU in 152 adults. They found the chat group to significantly reduce the risk for relapse with 46.5 and 22.2% of the participants experiencing a relapse within 1 year of inpatient discharge in the control and IG, respectively.

FUTURe DiReCTiONS FOR THe FielD

Although significant strides have been made in recent years regarding the development of effective IMIs for the prevention of MHD, there are several important directions for future research.

THe NeeD FOR MORe RiGOROUSlY CONDUCTeD lARGe-SCAle RANDOMiZeD CONTROlleD TRiAlS

First, the number of randomized controlled trials that have been conducted to date is very limited and so far it is not possible to draw definite conclusions about the potential of IMIs for the prevention of MHD for specific disorders. Only for the indicated prevention of depression there is consistent evidence across four different trials (three primary prevention trials aiming to reduce first incidence, one relapse prevention trial). However, only one primary prevention trial (48) and the relapse prevention trial (56) used standard diagnostic procedures, while the other two trials relied only on self-report questionnaires for onset identification. The only trial on the prevention of general anxiety did not result in positive findings. In terms of EDs, effects were only found in post hoc subgroup analyses, indicating that it might be possible to prevent ED onset for subpopulations of people at risk of developing EDs. Future studies need to identify those subpopulations likely to profit from preventive IMIs. It should be noted that two of the five successful prevention trials with positive findings (54,56) were based on very small sample sizes, whereas several much larger trials did not find positive results. Disorders not examined so far include substance use disorders, bipolar disorders, stress-related disorders, phobic disorders and panic disorder, obsessive-compulsive disorder, impulse-control disorders, somatic symptom disorder and insomnia. However, it is of note that there is quite substantial evidence for the effectiveness of health behavior change IMIs regarding the reduction of problematic alcohol consumption (24), improving sleep (66)(67)(68), reducing work-related stress (36,(69)(70)(71), all of which might be useful as MHD prevention IMIs as well. In summary, there is a need for more rigorously conducted large-scale randomized controlled trials using standard clinical diagnostic instruments for the selection of participants without MHD at baseline and the assessment of MHD onset.

ASSeSSiNG DiAGNOSTiC STATUS AT BASeliNe AND FOllOw-UP

Second, one general problem of prevention trials is that one needs very large sample sizes in order to be able to detect existing differences between groups, as transition rates to full blown disorders tend to be low during follow-ups of typical length of controlled studies even in high-risk groups. This problem is (could be) true of many of the studies reviewed above (49-51, 53, 54, 58). Given the low chance of positive findings in a trial that is not primarily designed nor powered to detect such findings, it is understandable that many prevention researchers abstain from assessing diagnostic status. However, even without positive findings such information would be very valuable for the field and we would like to encourage researchers to assess these data. Diagnostic status data could help to obtain the necessary information on the transition rates of the target population and generate hypotheses on the size of the effect on MHD onset, which are both necessary to design and power subsequent trials adequately. Moreover, if several of such smaller trials would be conducted, the data of these trials could be combined using individual participant data meta-analytic techniques (72,73). By collecting and pooling the primary data of individual trials, multiple underpowered trials can contribute to a large enough pooled sample size with sufficient power to examine effects on the incidence of MHD as well as analyzing patient subgroups and other effect modifying variables (74). If conducting observer-based clinical interviews is too expensive, web-based self-administered version of instruments such as the WHO-CIDI could be a low-cost alternative (75).

eXAMiNiNG DiFFeReNT PReveNTiON SeTTiNGS AND APPROACHeS

Provided that preventive IMIs are transferable to clinical praxis, we further need to establish the best way to implement preventive IMIs into our health care systems. Integrating IMIs as a first step of stepped-care approaches might be one promising way. Prevention IMIs for MHDs might also easily be integrated in already existing prevention programs (blended MHD prevention). That this would be worthwhile is supported by recent meta-analytic findings, indicating that traditional FTF interventions profit from providing additional IMI-components (76). Lindhiem and colleagues showed in their systematic review on 10 RCTs that a mobile component as a supplemental element in psychological interventions (e.g., SMS to support behavior changes between therapy sessions) considerably increase the effectiveness of these interventions compared to the respective strictly on-site interventions (SMD = 0.27) (76). IMIs also offer the unique potential of reaching people who would not access preventive mental health care via the established channels delivery, either because they do not utilize the available offers or because they do not feel comfortable discussing their mental health issues with their general practitioners and mental health specialists. Thus, we should also think about implementing preventive MHD-IMIs in a way that allows people to self-refer to IMIs [10]. This might, for example, be achievable by providing preventive IMIs via websites of established associations or as a direct prevention offer from health insurance companies, which would probably make it necessary for several countries to think about alternative financing health care models to integrate preventive IMIs in the best possible way. However, an approach just aimed at the GP and health insurance companies might be too narrow to exploit the potential of preventive services, as the majority of the target population might not use them. Preventive IMIs should be, therefore, I think that preventive interventions should be delivered through multiple channels that have "natural" possibilities to engage people, such as schools (they can reach all students), universities and colleges, pregnant women (because they all receive prenatal care), patients with general medical disorders, but also, for example, companies.

STUDieS iN CHilDReN, ADOleSCeNTS, AND YOUNG ADUlTS

Most of the trials that have been conducted up to this point have included only adults as participants. Although the general potential of IMIs to foster mental health in children and adolescents has been documented (20), only one study has investigated the effects of a prevention IMI, delivered as a universal preventive approach, on MHD onset (52). Given that ~75% of all MHD have their onset before the age of 25 (77), future studies should explore the potential of IMIs for preventing the first incidence in children, adolescents and young adults. That this is possible using a psychological intervention has been shown, for example, for depression (78). An interesting development in this field is a shift away from traditional computerized and browser-based interventions to mobile-based smart phones interventions. Using the most up-to-date technology and/or access paths for providing mental health prevention might increase the interventions attractiveness and user-friendliness in this modern technology oriented age group. However, evidence from mobile-based interventions and other mode of deliveries is yet scarce and future studies are needed to explore their potential. One of these other possibilities are serious games or even augmented reality interventions, that go beyond what can be done in typically "talking" interventions likely to attract children and adolescents. The potential of serious games to foster mental health has been shown, for example, in the field of depression (29,79), but yet there is no evidence regarding the prevention of MHD onset, with one trial currently being conducted (80). The use of augmented reality has to the best of our knowledge not yet been explored. One general problem with psychological interventions for the prevention of MHD in children and adolescents is that one needs parental consent, which is difficult to obtain online in a reliable manner, and which can be seen as barrier to reach these high-risk groups. Although many MHD already have their initial incidence before college matriculation (81), college entry might nevertheless be a very promising point in time to deliver preventive psychological interventions. College entry allows screening of the whole college student population, identification of those at risk for development of mental health problems, and subsequent offers of targeted preventive interventions. These might be disorder-specific prevention IMIs or trainings focusing on missing skills and competencies (e.g., procrastination, limited social competencies, and low self-efficacy) as well as other known risk factors for developing mental disorders. Similarly, entering vocational schools and the working environment might be a possibility to establish mental health screening and subsequent mental health trainings. In this context, where freshmen might be anxious about disclosing mental health issues, the possibility of IMIs being provided anonymously can be regarded as one substantial advantage over other occupational and college mental health management programs.

evAlUATiNG THe ROle OF HUMAN SUPPORT iN PReveNTive iNTeRveNTiONS

After development of an IMI, ongoing costs are directly related to guidance time. Hence, evaluating and comparing the effectiveness of interventions with different guidance formats is of particular importance. In the present review, only three of ten trials examined an unguided intervention, of which only one found significant, but very small effects on disorder onset. This is in line with previous findings from the clinical field that indicate that IMIs with human support have a significantly greater success than IMIs without therapeutic support (82)(83)(84). However, unguided IMIs might still produce larger effects at population level with regard to the reduction of disease burden, as more individuals could be reached at a given budget (85). A recent review on the cost-effectiveness of IMIs for improving mental health problems suggested that guided IMIs might be more costeffective than unguided IMIs despite their higher intervention costs per participants (86). Hence, there is a need for studies that compare not only the cost-effectiveness of guidance vs. no guidance in randomized trials but also different intensities and forms of guidance [e.g., guidance concept with individual feedback on the completed exercises, i.e., content feedback, vs. feedback aiming only to increase the adherence to the intervention (37)]. Moreover, the type of human support might not only have an impact on the effectiveness of interventions but also on the willingness to use such interventions. Given that the effects of interventions on a population level also depend on the acceptance and the reach of the target population, studies should address both effectiveness and reach of IMIs with different forms of guidance.

COST-eFFeCTiveNeSS STUDieS

Implementing preventive IMIs into our health care system might be a promising strategy regarding the cost-effectiveness of the health care system as has been recently estimated on the basis of a Markov-model study (87). However, evidence from randomized controlled trials is still scarce when it comes to IMIs for the prevention of MHD Studies indicated that guided Internet interventions for depression, anxiety, sleeping problems, smoking cessation, and alcohol consumption have favorable probabilities of being more cost-effective when compared to controls (86,88). However, these studies were mainly directed at the treatment of mental health problems, and only one study has to the best of our knowledge been published so far, that investigated the cost-effectiveness of an IMI with regard to the prevention of MHD onset (59). Two ongoing studies might provide first results in the near future (41,46).

POSSiBle ADveRSe eFFeCTS OF MHD PReveNTiON iMis

As with any other method, it is important to take into account the limitations and risks are involved with IMIs alongside all of the potential benefits of the procedure. At this stage, however, reliable empirical information showing negative effects of preventive IMIs has been very limited (89) and also in the present review, none of the identified studies reported results on potential negative effects.

Potential risks and negative effects include, depending on the concept, the following points, among others: (1) limited ability to timely identify patients prone to self-injury, for example, in relapse prevention interventions; (2) the development of reduced health-related self-efficacy if participants are not successful with a stand-alone IMI; and (3) the development of negative attitudes of non-responders toward psychological interventions in general and as a result a reduced willingness to utilize mental health care in case of MHD onset. Possible negative effects of such interventions cannot be ruled out at present, which counts to a similar degree also to classical FTF psychological interventions. There is an urgent need for further research.

One "cautionary tale" that has been published involves a secondary analysis of the impact of a mood management intervention embedded in an online smoking cessation randomized control trial. Participants came to the online site in order to stop smoking. Half of the sample was randomly assigned to a cognitive behavioral mood management intervention. The authors wondered if smokers at risk for major depressive episodes (defined as having subthreshold levels of major depression symptoms at baseline) who had been randomly assigned to receive the mood management intervention had lower incidence of major depressive episodes at follow up, thus showing a preventive effect. The results showed that the incidence was actually significantly greater for the group assigned to the mood management condition (90). The authors speculate that being assigned to a mood management intervention when one is not looking for such might make a participant more aware of depressive symptoms, thus increasing their self-report scores at follow-up assessments. They then examined a subsequent study in which participants in a similar online smoking cessation trial could freely choose (rather than being randomly assigned to) the elements of the interventions provided, including the same mood management intervention. In this study, participants screening positive for major depression were more likely to choose the mood management intervention, and, if they did so, were more likely to quit smoking (91).

These studies suggest that providing participants with a choice of interventions may be preferable to assigning them interventions that they did not choose and that participants are likely to choose appropriate interventions for themselves.

MAKe USe OF THe TeCHNOlOGiCAl POTeNTiAl OF iMis

All of investigated interventions were delivered over the Internet, only one study additionally used the mobile phone to facilitate the transfer of learned skills in daily life routine (48). None of the studies were delivered mobile only and none of the interventions' used smartphone sensors, wearables, or artificial intelligence algorithms. It seems that the field so far focused mainly on delivering psychological intervention as a (guided) self-help format through the Internet, without making full use of the technological potential of such approaches. Artificial intelligence algorithms based on user behavior might bare a great potential for supporting participants to change behavior, for example, in form of just-in-time adaptive intervention (92). However, their potential with regard to preventing MHD onset still needs to be proven and should be investigated in future studies.

DevelOPMeNT OF MUlTivARiATe PReDiCTiON AlGORiTHMS TO iDeNTiFY PeOPle AT RiSK AND MATCH PARTiCiPANTS TO iNTeRveNTiONS

One general problem in the field of prevention is identifying the right people to target with specific preventive interventions. Many, if not most, individuals displaying single risk factors stay disease free without intervening, which has also occurred in most of the trials reviewed above. The combination of several specific risk factors might be a promising strategy toward overcoming this problem (93), and has been utilized in some first trials (58). Recent advantages in the field of precision medicine and machine-learning techniques might further help to identify the people at highest risk who might profit from a preventive intervention. There have been first studies in the mental health field predicting MDD onset (94,95) in the general population, general anxiety and panic onset in general practice attendees (96) panic recurrence (97), or recurrence of suicidal ideation (97). A next necessary step in the field is to develop and validate such algorithms further for different populations and then, subsequently, test whether applying these risk prediction algorithms with subsequent preventive interventions is effective in reducing incidence of MHD in these high-risk groups.

The use of supervised machine-learning methods could also be used to explain the heterogeneity in intervention response (98,99) in order to finally match individual to specific interventions. The necessary large sample sizes to develop such prediction equations are feasible to obtain with scalable IMIs.

A high-risk group that has been noticeably absent from preventive IMI trials is the group of individuals with genetic markers associated with mental disorders. A recent study (100) suggests a method that could combine genetic research with IMI depression prevention research. A massive sample collected by the genetic screening company was used to identify 15 genetic loci associated with risk of major depression: 75,607 individuals reporting clinical diagnosis of depression were compared to 231,747 individuals reporting no history of depression. A replication data set (45,773 cases and 106,354 controls) was then used to confirm the findings.

This very large sample could be the basis for an interesting set of depression prevention studies. Subgroups of individuals who have no history of depression but have the genetic markers associated with risk could be recruited for randomized trials testing promising IMIs. Such studies could contribute to prevention science in several ways by helping to confirm whether individuals with the markers actually have higher risk for developing major depressive episodes, particularly when confronted with stressful life events. They could also determine prospectively which of the 15 loci yield the greatest risk and help determine whether interventions that can be conducted online can reduce incidence in individuals with genetic loading for depression.

TARGeTiNG UNDeRlYiNG RiSK AND PROTeCTive FACTORS iN iNDiviDUAllY TAilOReD iNTeRveNTiONS

The use of IMIs allows the provision of tailored interventions on large scale to a degree unlikely ever to be implementable using traditional FTF approaches. So far, most studies evaluated standardized interventions based on CBT, including standard packages (e.g., cognitive restructuring, behavioral activation, relaxation in a depression prevention intervention, etc.) for all participants regardless of the individual specific risk or protective factors, as well as intervention preferences. One potential next step for the field would be to develop and provide intervention modules that target specific underlying risk or protective factors (e.g., rumination, emotion regulation, social skills, experiential avoidance, compensatory behavior anxiety sensitivity, and physical activity) and tailor the combination of these modules based on the individual risk and need profiles of the participant. However, whether such an approach is superior to far more simple to develop and maintain standardized interventions that provide non-tailored to all participants is an empirical question that has yet to be adequately addressed.

STRATeGieS TO iNCReASe ReACH AND UTiliZATiON OF AvAilABle iNTeRveNTiONS

The impact of evidence-based preventive intervention on population level incidence heavily depends on the acceptance and use of such interventions in the target population (101). As the field of MHD prevention continues to make progress in identifying programs that yield positive effects, it will be important to develop and evaluate effective and cost-effective strategies to disseminate evidence-based programs. Hence, there is a need for studies that investigate potential obstacles in order to subsequently develop and evaluate strategies for overcoming them. For example, Ebert, Baumeister, and colleagues evaluated acceptance-facilitating interventions that address potential barriers for acceptance of IMIs in different target populations in a series of randomized controlled trials (102)(103)(104). Moessner and colleagues evaluated the effectiveness and cost-effectiveness of different school-based dissemination strategies for the prevention and early intervention in EDs (105). However, such experimentally examined strategies to increase the reach of preventive interventions are scarce and need to be conducted more often in order to fully exploit the potential of preventive interventions on the population level.

CONClUSiON

Internet-and mobile-based interventions are flexible, technically diverse methods which lend themselves to a variety of application areas. Such approaches have an ability to reach target groups in a way not yet achieved by classical FTF activities. A number of studies have shown that such interventions can be effective in preventing mental disorders. But clearly much more research is needed in order to fully determine the potential of IMIs for substantially reducing the immense disease burden of MHD at the population level.

AUTHOR CONTRiBUTiONS

DE drafted the first draft of the manuscript, all authors contributed to the further writing of the manuscript.

FiGURe 1 |
1Characteristics of Internet-and mobile-based interventions (IMIs).

TABle 1 |
1Summary of included randomized controlled trials that assessed MHD onset using categorical ICD/DSM diagnostic criteria.Study
Prevention
type

Disorder
Target group
Program
type

Program
Conditions
N
Follow-up instrument Results

Buntrock
et al. (48)

Indicated
Depression
Adults, subthreshold depression
(CES-D > 16)
No MDD

Stand-
alone

GET.ON mood enhancer
6 weeks CBT, guided self-help
for subthreshold depressive
symptoms

IG: intervention
CG: online-
psychoeducation

406
12 months SCID
MDD onset within
12 months

IG: 32%

CG: 47%

RRR = 39%

HR = 0.59

(p = 0.002)

NNT = 5.9

Christensen
et al. (49)

Selective
Depression
Adults, primary insomnia (MINI)
and depressive symptoms
(PHQ > 3 < 20)

No MDD

Stand-
alone

SHUTi
6 weeks unguided self-help for
insomnia symptoms

IG: intervention
CG: attention
control

1,149 6 months
MINI
MDD onset within 6 months
IG: 0.78%
CG: 1.13%
ns

Christensen
et al. (50)

Indicated
GAD
Adults 18-30, GAD symptoms
(GAD-7 > 5)

No PD, SP, BDP, schizophrenia,
psychosis

Not undergoing psychiatric
treatment

Stand-
alone

iChill
10 weeks unguided iCBT for
anxiety symptoms

IG1: unguided iChill

IG2: iCHill + phone
reminders

IG3: iChill + e-mail
reminders

CG1: attention
control website

CG2: attention
control
website + phone
reminders

558
6 months
MINI
GAD onset within 6 months

Across all IG: 6.7%

Across all CG: 4.5%

ns

Imamura
et al. (51)

Indicated
Depression
Adult workers with self-identified
subthreshold depressive symptoms
(WHO-CIDI 3.0, self-administered)

No MDD

Stand-
alone

6 weeks unguided iCBT,
manga comic-based
intervention for depression,
feedback on demand

IG: unguided iCBT
CG: e-mail with
non-CBT stress-
management tips

822
12 months WHO-CIDI
3.0 self-
administered

MDD onset within 6 months

IG: 0.8%

CG: 3.9%

HR = 0.22

RRR = 0.20

(p = 0.009)

NNT = 32

Lindenberg
and Kordy
(52)

Universal
EDs
Secondary education students
(13-16)

No ED diagnosis

Not undergoing treatment (ED)

Stepped
care

Young E[s]sprit stepped guided
intervention (ranging from
unguided feedback and self-
help, though peer support to
individual counseling)

IG: intervention
CG: online-
psychoeducation

1,667

a

12 months LIFE
Any ED onset within
12 months, IG1: 5.9%

CG1: 9.6%

(p = 0.038)

HR = 1.67

IG2: 5.6%

CG2: 4.8%

ns

(Continued)

TABle 1 |
1Continued

TABle 3 |
3Characteristics of studies and interventions that investigated the effectiveness of Internet-and mobile-based interventions on mental health disorders onset.Study
Target group
Prevention type
Media type
Program features
Cost-
effectiveness
evaluated

Reported
potential
negative
effects

Type of human
support

Children Adolescent Adults Universal Selective indicated internet Mobile Sensors wearables Algorithms
Guided Unguided
X

Taylor et al. (58)
X
X
X
X

Total number of studies
0
1
9
1
4
5
10
1
0
0
0
1
0
7
3

TABle 2 |
2Target conditions addressed by studies investigating the effectiveness of Internet-and mobile-based interventions on mental health disorders onset.Study
Unipolar
depression

Bipolar
eating
disorders

Psychosis Addiction
Stress-
related
disorders

Phobic
disorders

Panic
disorders

Obsessive-
compulsive
disorders

Generalized
anxiety

impulse
control
disorders

insomnia Transdiagnostic

Preventing Mental Disorders Using the Internet Frontiers in Psychiatry | www.frontiersin.org August 2017 | Volume 8 | Article 116
Conflict of Interest Statement:The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.The reviewer KW and handling editor declared their shared affiliation, and the handling editor states that the process met the standards of a fair and objective review.Copyright © 2017 Ebert, Cuijpers, Muñoz and Baumeister. This is an open-access article distributed under the terms of the Creative Commons Attribution License(CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys. R C Kessler, S Aguilar-Gaxiola, Alonso J Chatterji, S Lee, S Ormel, J , 10.1017/S1121189X00001421Epidemiol Psichiatr Soc. 18Kessler RC, Aguilar-Gaxiola S, Alonso J, Chatterji S, Lee S, Ormel J, et al. The global burden of mental disorders: an update from the WHO World Mental Health (WMH) surveys. Epidemiol Psichiatr Soc (2009) 18:23-33. doi:10.1017/S1121189X00001421

Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study. H A Whiteford, L Degenhardt, J Rehm, A J Baxter, A J Ferrari, H E Erskine, 10.1016/S0140-6736(13)61611-6Lancet. 382Whiteford HA, Degenhardt L, Rehm J, Baxter AJ, Ferrari AJ, Erskine HE, et al. Global burden of disease attributable to mental and substance use disorders: findings from the Global Burden of Disease Study 2010. Lancet (2013) 382:1575-86. doi:10.1016/S0140-6736(13)

Global burden of depressive disorders in the year 2000. T B Ustün, J L Ayuso-Mateos, S Chatterji, C Mathers, Cjl Murray, 10.1192/bjp.184.5.386Br J Psychiatry. 184Ustün TB, Ayuso-Mateos JL, Chatterji S, Mathers C, Murray CJL. Global burden of depressive disorders in the year 2000. Br J Psychiatry (2004) 184:386-92. doi:10.1192/bjp.184.5.386

Impact of psychiatric disorders on health-related quality of life: general population survey. S I Saarni, J Suvisaari, H Sintonen, S Pirkola, S Koskinen, A Aromaa, 10.1192/bjp.bp.106.025106Br J Psychiatry. 190Saarni SI, Suvisaari J, Sintonen H, Pirkola S, Koskinen S, Aromaa A, et al. Impact of psychiatric disorders on health-related quality of life: general population survey. Br J Psychiatry (2007) 190:326-32. doi:10.1192/bjp. bp.106.025106

Excess mortality in depression: a meta-analysis of community studies. P Cuijpers, F Smit, 10.1016/S0165-0327(01)00413-Xdoi:10.1016/ S0165-0327(01J Affect Disord. 72413Cuijpers P, Smit F. Excess mortality in depression: a meta-analysis of community studies. J Affect Disord (2002) 72:227-36. doi:10.1016/ S0165-0327(01)00413-X

Costs of nine common mental disorders: implications for curative and preventive psychiatry. F Smit, P Cuijpers, J Oostenbrink, N Batelaan, R De Graaf, A Beekman, J Ment Health Policy Econ. 9Smit F, Cuijpers P, Oostenbrink J, Batelaan N, de Graaf R, Beekman A. Costs of nine common mental disorders: implications for curative and preventive psychiatry. J Ment Health Policy Econ (2006) 9:193-200.

Depression: cost-of-illness studies in the international literature, a review. P Berto, D 'ilario, D Ruffo, P , Di Virgilio, R Rizzo, F , 10.1002/1099-176X(200003)3:1<3::AID-MHP68>3.0.CO;2-HJ Ment Health Policy Econ. 3Berto P, D'Ilario D, Ruffo P, Di Virgilio R, Rizzo F. Depression: cost-of-illness studies in the international literature, a review. J Ment Health Policy Econ (2000) 3:3-10. doi:10.1002/1099-176X(200003)3:1<3::AID-MHP68>3.0. CO;2-H

The economic burden of depression in the US: societal and patient perspectives. P E Greenberg, H G Birnbaum, 10.1517/146565220.127.116.119Expert Opin Pharmacother. 6Greenberg PE, Birnbaum HG. The economic burden of depression in the US: societal and patient perspectives. Expert Opin Pharmacother (2005) 6:369-76. doi:10.1517/14656522.214.171.1249

Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. S G Hofmann, Jaj Smits, 10.4088/JCP.v69n0415J Clin Psychiatry. 69Hofmann SG, Smits JAJ. Cognitive-behavioral therapy for adult anxiety disorders: a meta-analysis of randomized placebo-controlled trials. J Clin Psychiatry (2008) 69:621-32. doi:10.4088/JCP.v69n0415

Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. P Cuijpers, A Van Straten, G Andersson, P Van Oppen, 10.1037/a0013075J Consult Clin Psychol. 76Cuijpers P, van Straten A, Andersson G, van Oppen P. Psychotherapy for depression in adults: a meta-analysis of comparative outcome studies. J Consult Clin Psychol (2008) 76:909-22. doi:10.1037/a0013075

Utilising survey data to inform public policy: comparison of the cost-effectiveness of treatment of ten mental disorders. G Andrews, C Issakidis, K Sanderson, J Corry, H Lapsley, 10.1192/bjp.184.6.526doi:10.1192/ bjp.184.6.526Br J Psychiatry. 184Andrews G, Issakidis C, Sanderson K, Corry J, Lapsley H. Utilising survey data to inform public policy: comparison of the cost-effectiveness of treat- ment of ten mental disorders. Br J Psychiatry (2004) 184:526-33. doi:10.1192/ bjp.184.6.526

The treatment gap in mental health care. R Kohn, S Saxena, I Levav, B Saraceno, Bull World Health Organ. 82Kohn R, Saxena S, Levav I, Saraceno B. The treatment gap in mental health care. Bull World Health Organ (2004) 82:858-66.

Institute of medicine report on prevention of mental disorders. Summary and commentary. R F Muñoz, P J Mrazek, R J Haggerty, 10.1037/0003-066X.51.11.1116Am Psychol. 51Muñoz RF, Mrazek PJ, Haggerty RJ. Institute of medicine report on preven- tion of mental disorders. Summary and commentary. Am Psychol (1996) 51:1116-22. doi:10.1037/0003-066X.51.11.1116

Preventing the onset of major depressive disorder: a meta-analytic review of psychological interventions. K Van Zoonen, C Buntrock, D D Ebert, F Smit, C F Reynolds, A T Beekman, 10.1093/ije/dyt175Int J Epidemiol. 43van Zoonen K, Buntrock C, Ebert DD, Smit F, Reynolds CF, Beekman AT, et al. Preventing the onset of major depressive disorder: a meta-analytic review of psychological interventions. Int J Epidemiol (2014) 43:318-29. doi:10.1093/ije/dyt175

Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis. P Hutton, P J Taylor, 10.1017/S0033291713000354Psychol Med. 44Hutton P, Taylor PJ. Cognitive behavioural therapy for psychosis prevention: a systematic review and meta-analysis. Psychol Med (2013) 44:449-68. doi:10.1017/S0033291713000354

A meta-analytic review of eating disorder prevention programs: encouraging findings. E Stice, H Shaw, C N Marti, 10.1146/annurev.clinpsy.3.022806.091447Annu Rev Clin Psychol. 3Stice E, Shaw H, Marti CN. A meta-analytic review of eating disorder prevention programs: encouraging findings. Annu Rev Clin Psychol (2007) 3:207-31. doi:10.1146/annurev.clinpsy.3.022806.091447

A meta-analysis of adolescent psychosocial smoking prevention programs published between 1978 and 1997 in the United States. M S Hwang, K L Yeagley, R Petosa, doi:10.1177/ 1090198104263361Health Educ Behav. 31Hwang MS, Yeagley KL, Petosa R. A meta-analysis of adolescent psycho- social smoking prevention programs published between 1978 and 1997 in the United States. Health Educ Behav (2004) 31:702-19. doi:10.1177/ 1090198104263361

A meta-analysis of anxiety symptom prevention with cognitivebehavioral interventions. A K Zalta, 10.1016/j.janxdis.2011.02.007doi:10.1016/j. janxdis.2011.02.007J Anxiety Disord. 25Zalta AK. A meta-analysis of anxiety symptom prevention with cognitive- behavioral interventions. J Anxiety Disord (2011) 25:749-60. doi:10.1016/j. janxdis.2011.02.007

Cognitive behavior therapy via the Internet: a systematic review of applications, clinical efficacy and costeffectiveness. E Hedman, B Ljótsson, N Lindefors, 10.1586/erp.12.67Expert Rev Pharmacoecon Outcomes Res. 12Hedman E, Ljótsson B, Lindefors N. Cognitive behavior therapy via the Internet: a systematic review of applications, clinical efficacy and cost- effectiveness. Expert Rev Pharmacoecon Outcomes Res (2012) 12:745-64. doi:10.1586/erp.12.67

Internet and computer-based cognitive behavioral therapy for anxiety and depression in youth: a meta-analysis of randomized controlled outcome trials. D D Ebert, A-C Zarski, H Christensen, Y Stikkelbroek, P Cuijpers, M Berking, 10.1371/journal.pone.0119895PLoS One. 10119895Ebert DD, Zarski A-C, Christensen H, Stikkelbroek Y, Cuijpers P, Berking M, et al. Internet and computer-based cognitive behavioral therapy for anxiety and depression in youth: a meta-analysis of randomized controlled outcome trials. PLoS One (2015) 10:e0119895. doi:10.1371/journal.pone. 0119895

Computer-based psychological treatments for depression: a systematic review and meta-analysis. D Richards, T Richardson, 10.1016/j.cpr.2012.02.004Clin Psychol Rev. 32Richards D, Richardson T. Computer-based psychological treatments for depression: a systematic review and meta-analysis. Clin Psychol Rev (2012) 32:329-42. doi:10.1016/j.cpr.2012.02.004

Computer-aided psychotherapy for anxiety disorders: a meta-analytic review. P Cuijpers, I M Marks, A Van Straten, K Cavanagh, L Gega, G Andersson, 10.1080/16506070802694776Cogn Behav Ther. 38Cuijpers P, Marks IM, van Straten A, Cavanagh K, Gega L, Andersson G. Computer-aided psychotherapy for anxiety disorders: a meta-analytic review. Cogn Behav Ther (2009) 38:66-82. doi:10.1080/16506070802694776

Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults. E Mayo-Wilson, P Montgomery, 10.1002/14651858.CD005330.pub4Cochrane Database Syst Rev. 95330Mayo-Wilson E, Montgomery P. Media-delivered cognitive behavioural therapy and behavioural therapy (self-help) for anxiety disorders in adults. Cochrane Database Syst Rev (2013) 9:CD005330. doi:10.1002/14651858. CD005330.pub4

Effectiveness of guided and unguided low-intensity internet interventions for adult alcohol misuse: a meta-analysis. H Riper, M Blankers, H Hadiwijaya, J Cunningham, S Clarke, R Wiers, 10.1371/journal.pone.0099912PLoS One. 999912Riper H, Blankers M, Hadiwijaya H, Cunningham J, Clarke S, Wiers R, et al. Effectiveness of guided and unguided low-intensity internet interventions for adult alcohol misuse: a meta-analysis. PLoS One (2014) 9:e99912. doi:10.1371/journal.pone.0099912

Computerised cognitive behavioural therapy for insomnia: a systematic review and meta-analysis. S K Cheng, J Dizon, 10.1159/000335379Psychother Psychosom. 81Cheng SK, Dizon J. Computerised cognitive behavioural therapy for insom- nia: a systematic review and meta-analysis. Psychother Psychosom (2012) 81:206-16. doi:10.1159/000335379

Klinische Psychologie und Psychotherapie für Bachelor. D D Ebert, D Erbe, Berking M, Rief WSpringer-LehrbuchBerlin, Heidelberg; Berlin HeidelbergInternet-basierte psychologische interventionenEbert DD, Erbe D. Internet-basierte psychologische interventionen. In: Berking M, Rief W, editors. Klinische Psychologie und Psychotherapie für Bachelor. Berlin, Heidelberg: Springer Berlin Heidelberg; Springer-Lehrbuch (2012). p. 131-40.

Therapist-delivered internet psychotherapy for depression in primary care: a randomised controlled trial. D Kessler, G Lewis, S Kaur, N Wiles, M King, S Weich, 10.1016/S0140-6736(09)61257-5Lancet. 374Kessler D, Lewis G, Kaur S, Wiles N, King M, Weich S, et al. Therapist-delivered internet psychotherapy for depression in primary care: a randomised controlled trial. Lancet (2009) 374:628-34. doi:10.1016/S0140-6736(09) 61257-5

Virtual reality in the treatment of spider phobia: a controlled study. A Garcia-Palacios, H Hoffman, A Carlin, T A Furness, C Botella, 10.1016/S0005-7967(01)00068-7Behav Res Ther. 40Garcia-Palacios A, Hoffman H, Carlin A, Furness TA, Botella C. Virtual reality in the treatment of spider phobia: a controlled study. Behav Res Ther (2002) 40:983-93. doi:10.1016/S0005-7967(01)00068-7

The effectiveness of SPARX, a computerised self help intervention for adolescents seeking help for depression: randomised controlled non-inferiority trial. S N Merry, K Stasiak, M Shepherd, C Frampton, T Fleming, Mfg Lucassen, 10.1136/bmj.e2598BMJ. 3442598Merry SN, Stasiak K, Shepherd M, Frampton C, Fleming T, Lucassen MFG. The effectiveness of SPARX, a computerised self help intervention for ado- lescents seeking help for depression: randomised controlled non-inferiority trial. BMJ (2012) 344:e2598. doi:10.1136/bmj.e2598

. J Lin, D D Ebert, D Lehr, M Berking, H Baumeister, Internet based cognitive behavioral interventions: state of the art and implementation possibilities in rehabilitationLin J, Ebert DD, Lehr D, Berking M, Baumeister H. [Internet based cognitive behavioral interventions: state of the art and implementation possibilities in rehabilitation].

. 10.1055/s-0033-1343491doi:10.1055/ s-0033-1343491Rehabilitation (Stuttg). 52Rehabilitation (Stuttg) (2013) 52:155-63. doi:10.1055/ s-0033-1343491

Internet-based psychodynamic versus cognitive behavioral guided self-help for generalized anxiety disorder: a randomized controlled trial. G Andersson, B Paxling, P Roch-Norlund, G Ostman, A Norgren, J Almlöv, 10.1159/000339371Psychother Psychosom. 81Andersson G, Paxling B, Roch-Norlund P, Ostman G, Norgren A, Almlöv J, et al. Internet-based psychodynamic versus cognitive behavioral guided self-help for generalized anxiety disorder: a randomized controlled trial. Psychother Psychosom (2012) 81:344-55. doi:10.1159/000339371

Transdiagnostic, affect-focused, psychodynamic, guided self-help for depression and anxiety through the Internet: study protocol for a randomised controlled trial. R Johansson, H Hesser, B Ljótsson, R J Frederick, G Andersson, 10.1136/bmjopen-2012-002167BMJ Open. 22167Johansson R, Hesser H, Ljótsson B, Frederick RJ, Andersson G. Transdiagnostic, affect-focused, psychodynamic, guided self-help for depression and anxiety through the Internet: study protocol for a randomised controlled trial. BMJ Open (2012) 2:e002167. doi:10.1136/bmjopen-2012-002167

Predictors and moderators of response to Internet-delivered interpersonal psychotherapy and cognitive behavior therapy for depression. T Donker, P J Batterham, L Warmerdam, K Bennett, A Bennett, P Cuijpers, 10.1016/j.jad.2013.06.020J Affect Disord. 151Donker T, Batterham PJ, Warmerdam L, Bennett K, Bennett A, Cuijpers P, et al. Predictors and moderators of response to Internet-delivered interper- sonal psychotherapy and cognitive behavior therapy for depression. J Affect Disord (2013) 151:343-51. doi:10.1016/j.jad.2013.06.020

Enhancing webbased mindfulness training for mental health promotion with the health action process approach: randomized controlled trial. Wws Mak, Aty Chan, Eyl Cheung, Cly Lin, Kcs Ngai, 10.2196/jmir.3746J Med Internet Res. 178Mak WWS, Chan ATY, Cheung EYL, Lin CLY, Ngai KCS. Enhancing web- based mindfulness training for mental health promotion with the health action process approach: randomized controlled trial. J Med Internet Res (2015) 17:e8. doi:10.2196/jmir.3746

Effectiveness and cost-effectiveness of a guided and unguided Internetbased acceptance and commitment therapy for chronic pain: study protocol for a three-armed randomised controlled trial. J Lin, M Lüking, D D Ebert, M Buhrman, G Andersson, H Baumeister, 10.1016/j.invent.2014.11.005Internet Interv. 2Lin J, Lüking M, Ebert DD, Buhrman M, Andersson G, Baumeister H. Effectiveness and cost-effectiveness of a guided and unguided Internet- based acceptance and commitment therapy for chronic pain: study protocol for a three-armed randomised controlled trial. Internet Interv (2015) 2:7-16. doi:10.1016/j.invent.2014.11.005

Internet-and mobile-based stress management for employees with adherence-focused guidance: efficacy and mechanism of change. D D Ebert, D Lehr, E Heber, H Riper, P Cuijpers, M Berking, 10.5271/sjweh.3573Scand J Work Environ Health. 42Ebert DD, Lehr D, Heber E, Riper H, Cuijpers P, Berking M. Internet-and mobile-based stress management for employees with adherence-focused guidance: efficacy and mechanism of change. Scand J Work Environ Health (2016) 42:382-94. doi:10.5271/sjweh.3573

Adherence to Internet-based mobile-supported stress management: a pooled analysis of individual participant data from three randomized controlled trials. A-C Zarski, D Lehr, M Berking, H Riper, P Cuijpers, D D Ebert, 10.2196/jmir.4493J Med Internet Res. 18146Zarski A-C, Lehr D, Berking M, Riper H, Cuijpers P, Ebert DD. Adherence to Internet-based mobile-supported stress management: a pooled analysis of individual participant data from three randomized controlled trials. J Med Internet Res (2016) 18:e146. doi:10.2196/jmir.4493

Internetbasierte psychotherapien: besonderheiten und empirische evidenz. T Berger, G Andersson, 10.1055/s-0028-1090162doi:10.1055/ s-0028-1090162Psychother Psych Med. 59Berger T, Andersson G. Internetbasierte psychotherapien: besonderheiten und empirische evidenz. Psychother Psych Med (2009) 59:159-70. doi:10.1055/ s-0028-1090162

What is the impact of mental health-related stigma on help-seeking? A systematic review of quantitative and qualitative studies. S Clement, O Schauman, T Graham, F Maggioni, S Evans-Lacko, N Bezborodovs, 10.1017/S0033291714000129Psychol Med. 45Clement S, Schauman O, Graham T, Maggioni F, Evans-Lacko S, Bezborodovs N, et al. What is the impact of mental health-related stigma on help-seeking? A systematic review of quantitative and qualitative studies. Psychol Med (2015) 45:11-27. doi:10.1017/S0033291714000129

Mental illness stigma, help seeking, and public health programs. C Henderson, S Evans-Lacko, G Thornicroft, 10.2105/AJPH.2012.301056Am J Public Health. 103Henderson C, Evans-Lacko S, Thornicroft G. Mental illness stigma, help seeking, and public health programs. Am J Public Health (2013) 103:777-80. doi:10.2105/AJPH.2012.301056

Evaluating the efficacy and cost-effectiveness of web-based indicated prevention of major depression: design of a randomised controlled trial. C Buntrock, D D Ebert, D Lehr, P Cuijpers, H Riper, F Smit, 10.1186/1471-244X-14-25BMC Psychiatry. 1425Buntrock C, Ebert DD, Lehr D, Cuijpers P, Riper H, Smit F, et al. Evaluating the efficacy and cost-effectiveness of web-based indicated prevention of major depression: design of a randomised controlled trial. BMC Psychiatry (2014) 14:25. doi:10.1186/1471-244X-14-25

For whom does it work? Moderators of outcome on the effect of a transdiagnostic Internet-based maintenance treatment after inpatient psychotherapy: randomized controlled trial. D D Ebert, M Gollwitzer, H Riper, P Cuijpers, H Baumeister, M Berking, 10.2196/jmir.2511doi:10.2196/ jmir.2511J Med Internet Res. 15191Ebert DD, Gollwitzer M, Riper H, Cuijpers P, Baumeister H, Berking M. For whom does it work? Moderators of outcome on the effect of a transdiag- nostic Internet-based maintenance treatment after inpatient psychotherapy: randomized controlled trial. J Med Internet Res (2013) 15:e191. doi:10.2196/ jmir.2511

A transdiagnostic Internet-based maintenance treatment enhances the stability of outcome after inpatient cognitive behavioral therapy: a randomized controlled trial. D D Ebert, T Tarnowski, M Gollwitzer, B Sieland, M Berking, 10.1159/000345967Psychother Psychosom. 82Ebert DD, Tarnowski T, Gollwitzer M, Sieland B, Berking M. A transdiagnos- tic Internet-based maintenance treatment enhances the stability of outcome after inpatient cognitive behavioral therapy: a randomized controlled trial. Psychother Psychosom (2013) 82:246-56. doi:10.1159/000345967

The exploration of the effectiveness of group therapy through an Internet chat as aftercare: a controlled naturalistic study. V Golkaramnay, S Bauer, S Haug, M Wolf, H Kordy, 10.1159/000101500Psychother Psychosom. 76Golkaramnay V, Bauer S, Haug S, Wolf M, Kordy H. The exploration of the effectiveness of group therapy through an Internet chat as aftercare: a controlled naturalistic study. Psychother Psychosom (2007) 76:219-25. doi:10.1159/000101500

Mobile cognitive therapy: adherence and acceptability of an online intervention in remitted recurrently depressed patients. G Kok, C Bockting, H Burger, F Smit, H Riper, 10.1016/j.invent.2014.05.002doi:10.1016/j. invent.2014.05.002Internet Interv. 1Kok G, Bockting C, Burger H, Smit F, Riper H. Mobile cognitive therapy: adherence and acceptability of an online intervention in remitted recur- rently depressed patients. Internet Interv (2014) 1:65-73. doi:10.1016/j. invent.2014.05.002

Disrupting the rhythm of depression using mobile cognitive therapy for recurrent depression: randomized controlled trial design and protocol. Clh Bockting, G D Kok, L Van Der Kamp, F Smit, E Van Valen, R Schoevers, 10.1186/1471-244X-11-12BMC Psychiatry. Bockting CLH, Kok GD, van der Kamp L, Smit F, van Valen E, Schoevers R, et al. Disrupting the rhythm of depression using mobile cognitive therapy for recurrent depression: randomized controlled trial design and protocol. BMC Psychiatry (2011) 11:12. doi:10.1186/1471-244X-11-12

Effectiveness of Internet-based interventions for the prevention of mental disorders: a systematic review and meta-analysis. L Sander, L Rausch, H Baumeister, 10.2196/mental.6061JMIR Ment Heal. 338Sander L, Rausch L, Baumeister H. Effectiveness of Internet-based inter- ventions for the prevention of mental disorders: a systematic review and meta-analysis. JMIR Ment Heal (2016) 3:e38. doi:10.2196/mental.6061

Effect of a web-based guided self-help intervention for prevention of major depression in adults with subthreshold depression: a randomized clinical trial. C Buntrock, D D Ebert, D Lehr, F Smit, H Riper, M Berking, 10.1001/jama.2016.4326J Am Med Assoc. 315Buntrock C, Ebert DD, Lehr D, Smit F, Riper H, Berking M, et al. Effect of a web-based guided self-help intervention for prevention of major depression in adults with subthreshold depression: a randomized clinical trial. J Am Med Assoc (2016) 315:1854-63. doi:10.1001/jama.2016.4326

Effectiveness of an online insomnia program (SHUTi) for prevention of depressive episodes (the GoodNight Study): a randomised controlled trial. H Christensen, P J Batterham, J A Gosling, L M Ritterband, K M Griffiths, F P Thorndike, 10.1016/S2215-0366(15)00536-2doi:10.1016/ S2215-0366Lancet Psychiatry. 315Christensen H, Batterham PJ, Gosling JA, Ritterband LM, Griffiths KM, Thorndike FP, et al. Effectiveness of an online insomnia program (SHUTi) for prevention of depressive episodes (the GoodNight Study): a ran- domised controlled trial. Lancet Psychiatry (2016) 3:333-41. doi:10.1016/ S2215-0366(15)00536-2

Prevention of generalized anxiety disorder using a web intervention, iChill: randomized controlled trial. H Christensen, P Batterham, A Mackinnon, K M Griffiths, Kalia Hehir, K Kenardy, J , 10.2196/jmir.3507J Med Internet Res. 16199Christensen H, Batterham P, Mackinnon A, Griffiths KM, Kalia Hehir K, Kenardy J, et al. Prevention of generalized anxiety disorder using a web intervention, iChill: randomized controlled trial. J Med Internet Res (2014) 16:e199. doi:10.2196/jmir.3507

Does Internet-based cognitive behavioral therapy (iCBT) prevent major depressive episode for workers? A 12-month follow-up of a randomized controlled trial. K Imamura, N Kawakami, T A Furukawa, Y Matsuyama, A Shimazu, R Umanodan, 10.1017/S0033291714003006doi:10.1017/ S0033291714003006Psychol Med. 45Imamura K, Kawakami N, Furukawa TA, Matsuyama Y, Shimazu A, Umanodan R, et al. Does Internet-based cognitive behavioral therapy (iCBT) prevent major depressive episode for workers? A 12-month follow-up of a randomized controlled trial. Psychol Med (2015) 45:1907-17. doi:10.1017/ S0033291714003006

Wirksamkeit eines gestuften, Internetvermittelten Ansatzes zur Prävention von Essstörungen bei Schülern der 7. bis 10. K Lindenberg, H Kordy, 10.1026/0942-5403/a000152Klasse. Kindheit Entwicklung. 24Lindenberg K, Kordy H. Wirksamkeit eines gestuften, Internetvermittelten Ansatzes zur Prävention von Essstörungen bei Schülern der 7. bis 10. Klasse. Kindheit Entwicklung (2015) 24:55-63. doi:10.1026/0942-5403/a000152

Prevention of eating disorders in at-risk college-age women. C B Taylor, S Bryson, K H Luce, D Cunning, A C Doyle, L B Abascal, 10.1001/archpsyc.63.8.881Arch Gen Psychiatry. 63Taylor CB, Bryson S, Luce KH, Cunning D, Doyle AC, Abascal LB, et al. Prevention of eating disorders in at-risk college-age women. Arch Gen Psychiatry (2006) 63:881-8. doi:10.1001/archpsyc.63.8.881

Expanding the efficacy of project UPLIFT: distance delivery of mindfulness-based depression prevention to people with epilepsy. N J Thompson, A H Patel, L M Selwa, S C Stoll, C E Begley, E K Johnson, 10.1037/a0038404J Consult Clin Psychol. 83Thompson NJ, Patel AH, Selwa LM, Stoll SC, Begley CE, Johnson EK, et al. Expanding the efficacy of project UPLIFT: distance delivery of mindful- ness-based depression prevention to people with epilepsy. J Consult Clin Psychol (2015) 83:304-13. doi:10.1037/a0038404

Two-year outcome of Internet-based relapse prevention for partially remitted depression. F Holländare, S A Anthony, M Randestad, M Tillfors, P Carlbring, G Andersson, 10.1016/j.brat.2013.08.002Behav Res Ther. 5111Holländare F, Anthony SA, Randestad M, Tillfors M, Carlbring P, Andersson G, et al. Two-year outcome of Internet-based relapse prevention for partially remitted depression. Behav Res Ther (2013) 51(11):719-22. doi:10.1016/j.brat.2013.08.002

Randomized trial of Internet-based relapse prevention for partially remitted depression. F Holländare, S Johnsson, M Randestad, M Tillfors, P Carlbring, G Andersson, 10.1111/j.1600-0447.2011.01698.xActa Psychiatr Scand. 124Holländare F, Johnsson S, Randestad M, Tillfors M, Carlbring P, Andersson G, et al. Randomized trial of Internet-based relapse prevention for partially remitted depression. Acta Psychiatr Scand (2011) 124:285-94. doi:10.1111/j.1600-0447.2011.01698.x

The effectiveness of Internet chat groups in relapse prevention after inpatient psychotherapy. S Bauer, M Wolf, S Haug, H Kordy, 10.1080/10503307.2010.547530Psychother Res. 21Bauer S, Wolf M, Haug S, Kordy H. The effectiveness of Internet chat groups in relapse prevention after inpatient psychotherapy. Psychother Res (2011) 21:219-26. doi:10.1080/10503307.2010.547530

Reducing eating disorder onset in a very high risk sample with significant comorbid depression: a randomized controlled trial. C B Taylor, A E Kass, M Trockel, D Cunning, H Weisman, J Bailey, 10.1037/ccp0000077J Consult Clin Psychol. 84Taylor CB, Kass AE, Trockel M, Cunning D, Weisman H, Bailey J, et al. Reducing eating disorder onset in a very high risk sample with significant comorbid depression: a randomized controlled trial. J Consult Clin Psychol (2016) 84:402-14. doi:10.1037/ccp0000077

Preventing depression in adults with subthreshold depression: health-economic evaluation alongside a pragmatic randomized controlled trial of a web-based intervention. C Buntrock, M Berking, F Smit, D Lehr, S Nobis, H Riper, 10.2196/jmir.6587J Med Internet Res. 195Buntrock C, Berking M, Smit F, Lehr D, Nobis S, Riper H, et al. Preventing depression in adults with subthreshold depression: health-economic eval- uation alongside a pragmatic randomized controlled trial of a web-based intervention. J Med Internet Res (2017) 19:e5. doi:10.2196/jmir.6587

Effectiveness of a web-based cognitive behavioural intervention for subthreshold depression: pragmatic randomised controlled trial. C Buntrock, D D Ebert, D Lehr, H Riper, F Smit, P Cuijpers, 10.1159/000438673Psychother Psychosom. 84Buntrock C, Ebert DD, Lehr D, Riper H, Smit F, Cuijpers P, et al. Effectiveness of a web-based cognitive behavioural intervention for subthreshold depres- sion: pragmatic randomised controlled trial. Psychother Psychosom (2015) 84:348-58. doi:10.1159/000438673

The GoodNight study -online CBT for insomnia for the indicated prevention of depression: study protocol for a randomised controlled trial. J A Gosling, N Glozier, K Griffiths, L M Ritterband, Thorndike F Mackinnon, A , 10.1186/1745-6215-15-56Trials. 1556Gosling JA, Glozier N, Griffiths K, Ritterband LM, Thorndike F, Mackinnon A, et al. The GoodNight study -online CBT for insomnia for the indicated prevention of depression: study protocol for a randomised controlled trial. Trials (2014) 15:56. doi:10.1186/1745-6215-15-56

Who is really at risk? Identifying risk factors for subthreshold and full syndrome eating disorders in a high-risk sample. C Jacobi, E Fittig, S W Bryson, D Wilfley, H C Kraemer, C B Taylor, 10.1017/S0033291710002631Psychol Med. 41Jacobi C, Fittig E, Bryson SW, Wilfley D, Kraemer HC, Taylor CB. Who is really at risk? Identifying risk factors for subthreshold and full syndrome eating disorders in a high-risk sample. Psychol Med (2011) 41:1939-49. doi:10.1017/S0033291710002631

Effects of an Internet-based intervention for subthreshold eating disorders: a randomized controlled trial. C Jacobi, U Völker, M T Trockel, C B Taylor, 10.1016/j.brat.2011.09.013Behav Res Ther. 50Jacobi C, Völker U, Trockel MT, Taylor CB. Effects of an Internet-based intervention for subthreshold eating disorders: a randomized controlled trial. Behav Res Ther (2012) 50:93-9. doi:10.1016/j.brat.2011.09.013

Developing an online psychoeducation package for bipolar disorder. E Barnes, S Simpson, E Griffiths, K Hood, N Craddock, D J Smith, 10.3109/09638237.2010.525565J Ment Health. 20Barnes E, Simpson S, Griffiths E, Hood K, Craddock N, Smith DJ. Developing an online psychoeducation package for bipolar disorder. J Ment Health (2011) 20:21-31. doi:10.3109/09638237.2010.525565

A web-based preventive intervention program for bipolar disorder: outcome of a 12-months randomized controlled trial. C W Barnes, D Hadzi-Pavlovic, K Wilhelm, P B Mitchell, J Angst, C Barnes, 10.1016/j.jad.2014.11.038J Affect Disord. 174Barnes CW, Hadzi-Pavlovic D, Wilhelm K, Mitchell PB, Angst J, Barnes C, et al. A web-based preventive intervention program for bipolar disorder: outcome of a 12-months randomized controlled trial. J Affect Disord (2015) 174:485-92. doi:10.1016/j.jad.2014.11.038

Restoring depleted resources: efficacy and mechanisms of change of an Internetbased unguided recovery training for better sleep and psychological detachment from work. D D Ebert, M Berking, H Thiart, H Riper, J Laferton, D Lehr, doi:10.1037/ hea0000277Heal Psychol. 34Ebert DD, Berking M, Thiart H, Riper H, Laferton J, Lehr D. Restoring depleted resources: efficacy and mechanisms of change of an Internet- based unguided recovery training for better sleep and psychological detachment from work. Heal Psychol (2015) 34S:1240-51. doi:10.1037/ hea0000277

Log in and breathe out: Internet-based recovery training for sleepless employees with work-related strain -results of a randomized controlled trial. H Thiart, D Lehr, D D Ebert, M Berking, H Riper, 10.5271/sjweh.3478Scand J Work Environ Health. 412Thiart H, Lehr D, Ebert DD, Berking M, Riper H. Log in and breathe out: Internet-based recovery training for sleepless employees with work-related strain -results of a randomized controlled trial. Scand J Work Environ Health (2015) 41(2):164-74. doi:10.5271/sjweh.3478

Efficacy of Internetdelivered cognitive-behavioral therapy for insomnia -a systematic review and meta-analysis of randomized controlled trials. R Zachariae, M S Lyby, L Ritterband, O 'toole, M S , 10.1016/j.smrv.2015.10.004Sleep Med Rev. 30Zachariae R, Lyby MS, Ritterband L, O'Toole MS. Efficacy of Internet- delivered cognitive-behavioral therapy for insomnia -a systematic review and meta-analysis of randomized controlled trials. Sleep Med Rev (2015) 30:1-10. doi:10.1016/j.smrv.2015.10.004

Occupational eMental Health" in der Lehrergesundheit: Ein metaanalytisches Review zur Wirksamkeit von Online-Gesundheitstrainings bei Lehrkräften. D Lehr, E Heber, B Sieland, A Hillert, B Funk, D D Ebert, 10.1007/s11553-016-0541-6Prav Gesundheitsf. 11Lehr D, Heber E, Sieland B, Hillert A, Funk B, Ebert DD. "Occupational eMental Health" in der Lehrergesundheit: Ein metaanalytisches Review zur Wirksamkeit von Online-Gesundheitstrainings bei Lehrkräften. Prav Gesundheitsf (2016) 11:182-92. doi:10.1007/s11553-016-0541-6

Web-based and mobile stress management intervention for employees: results of a randomised controlled trial. E Heber, D Lehr, D D Ebert, M Berking, H Riper, 10.2196/jmir.5112J Med Internet Res. 1821Heber E, Lehr D, Ebert DD, Berking M, Riper H. Web-based and mobile stress management intervention for employees: results of a randomised controlled trial. J Med Internet Res (2016) 18:e21. doi:10.2196/jmir.5112

Self-guided Internet-based and mobile-based stress management for employees: results of a randomised controlled trial. D D Ebert, E Heber, M Berking, H Riper, P Cuijpers, B Funk, 10.1136/oemed-2015-103269Occup Environ Med. 73Ebert DD, Heber E, Berking M, Riper H, Cuijpers P, Funk B, et al. Self-guided Internet-based and mobile-based stress management for employees: results of a randomised controlled trial. Occup Environ Med (2016) 73:315-23. doi:10.1136/oemed-2015-103269

Individual patient data meta-analyses. M J Clarke, 10.1016/j.bpobgyn.2004.10.011Best Pract Res Clin Obstet Gynaecol. 19Clarke MJ. Individual patient data meta-analyses. Best Pract Res Clin Obstet Gynaecol (2005) 19:47-55. doi:10.1016/j.bpobgyn.2004.10.011

Meta-analysis of individual participant data: rationale, conduct, and reporting. R D Riley, P C Lambert, G Abo-Zaid, 10.1136/bmj.c221doi:10.1136/ bmj.c221BMJ. 340221Riley RD, Lambert PC, Abo-Zaid G. Meta-analysis of individual participant data: rationale, conduct, and reporting. BMJ (2010) 340:c221. doi:10.1136/ bmj.c221

The relative benefits of meta-analysis conducted with individual participant data versus aggregated data. H Cooper, E A Patall, 10.1037/a0015565Psychol Methods. 14Cooper H, Patall EA. The relative benefits of meta-analysis conducted with individual participant data versus aggregated data. Psychol Methods (2009) 14:165-76. doi:10.1037/a0015565

Are computerized interviews equivalent to human interviewers? CIDI-auto versus CIDI in anxiety and depressive disorders. L Peters, D Clark, F Carroll, 10.1017/S0033291798006655doi:10.1017/ S0033291798006655Psychol Med. 28Peters L, Clark D, Carroll F. Are computerized interviews equiva- lent to human interviewers? CIDI-auto versus CIDI in anxiety and depressive disorders. Psychol Med (1998) 28:893-901. doi:10.1017/ S0033291798006655

Mobile technology boosts the effectiveness of psychotherapy and behavioral interventions: a meta-analysis. O Lindhiem, C B Bennett, D Rosen, J Silk, 10.1177/0145445515595198Behav Modif. 39Lindhiem O, Bennett CB, Rosen D, Silk J. Mobile technology boosts the effectiveness of psychotherapy and behavioral interventions: a meta-analysis. Behav Modif (2015) 39:785-804. doi:10.1177/0145445515595198

Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. R C Kessler, P Berglund, O Demler, Jin R Merikangas, K R Walters, E E , 10.1001/archpsyc.62.6.593Arch Gen Psychiatry. 62593Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry (2005) 62:593. doi:10.1001/archpsyc.62.6.593

Psychological and educational interventions for preventing depression in children and adolescents. S N Merry, S E Hetrick, G R Cox, T Brudevold-Iversen, J J Bir, H Mcdowell, 10.1002/14651858.CD003380.pub3Cochrane Database Syst Rev. 123380Merry SN, Hetrick SE, Cox GR, Brudevold-Iversen T, Bir JJ, McDowell H. Psychological and educational interventions for preventing depression in children and adolescents. Cochrane Database Syst Rev (2011) (12):CD003380. doi:10.1002/14651858.CD003380.pub3

A pragmatic randomized controlled trial of computerized CBT (SPARX) for symptoms of depression among adolescents excluded from mainstream education. T Fleming, R Dixon, C Frampton, S Merry, 10.1017/S1352465811000695Behav Cogn Psychother. 40Fleming T, Dixon R, Frampton C, Merry S. A pragmatic randomized controlled trial of computerized CBT (SPARX) for symptoms of depression among adolescents excluded from mainstream education. Behav Cogn Psychother (2012) 40:529-41. doi:10.1017/S1352465811000695

Trial for the prevention of depression (TriPoD) in final-year secondary students: study protocol for a cluster randomised controlled trial. Y Perry, A L Calear, A Mackinnon, P J Batterham, J Licinio, C King, 10.1186/s13063-015-0929-1Trials. 16451Perry Y, Calear AL, Mackinnon A, Batterham PJ, Licinio J, King C, et al. Trial for the prevention of depression (TriPoD) in final-year secondary students: study protocol for a cluster randomised controlled trial. Trials (2015) 16:451. doi:10.1186/s13063-015-0929-1

Mental disorders among college students in the World Health Organization World Mental Health Surveys. R P Auerbach, J Alonso, W G Axinn, P Cuijpers, D D Ebert, J G Green, 10.1017/S0033291716001665doi:10.1017/ S0033291716001665Psychol Med. 46Auerbach RP, Alonso J, Axinn WG, Cuijpers P, Ebert DD, Green JG, et al. Mental disorders among college students in the World Health Organization World Mental Health Surveys. Psychol Med (2016) 46:2955-70. doi:10.1017/ S0033291716001665

The impact of guidance on Internet-based mental health interventions-a systematic review. H Baumeister, L Reichler, M Munzinger, J Lin, 10.1016/j.invent.2014.08.003Internet Interv. 1Baumeister H, Reichler L, Munzinger M, Lin J. The impact of guidance on Internet-based mental health interventions-a systematic review. Internet Interv (2014) 1:205-15. doi:10.1016/j.invent.2014.08.003

Internet-delivered treatments with or without therapist input: does the therapist factor have implications for efficacy and cost?. B Palmqvist, P Carlbring, G Andersson, 10.1586/14737126.96.36.1991Expert Rev Pharmacoecon Outcomes Res. 7Palmqvist B, Carlbring P, Andersson G. Internet-delivered treatments with or without therapist input: does the therapist factor have implications for efficacy and cost? Expert Rev Pharmacoecon Outcomes Res (2007) 7:291-7. doi:10.1586/14737126.96.36.1991

J P Klein, T Berger, 10.1159/000354046Internetbasierte psychologische Behandlung bei Depressionen. Verhaltenstherapie. 23Klein JP, Berger T. Internetbasierte psychologische Behandlung bei Depressionen. Verhaltenstherapie (2013) 23:149-59. doi:10.1159/000354046

Efficacy and cost-effectiveness of minimal guided and unguided Internet-based mobile supported stress-management in employees with occupational stress: a three-armed randomised controlled trial. D D Ebert, D Lehr, F Smit, A-C Zarski, H Riper, E Heber, 10.1186/1471-2458-14-807BMC Public Health14807Ebert DD, Lehr D, Smit F, Zarski A-C, Riper H, Heber E, et al. Efficacy and cost-effectiveness of minimal guided and unguided Internet-based mobile supported stress-management in employees with occupational stress: a three-armed randomised controlled trial. BMC Public Health (2014) 14:807. doi:10.1186/1471-2458-14-807

Economic evaluations of Internet interventions for mental health:a systematic review. T Donker, M Blankers, E Hedman, B Ljótsson, K Petrie, H Christensen, 10.1017/S0033291715001427Psychol Med. 45Donker T, Blankers M, Hedman E, Ljótsson B, Petrie K, Christensen H. Economic evaluations of Internet interventions for mental health:a systematic review. Psychol Med (2015) 45:3357-76. doi:10.1017/S0033291715001427

Improving the cost-effectiveness of a healthcare system for depressive disorders by implementing telemedicine: a health economic modeling study. J Lokkerbol, D Adema, P Cuijpers, C F Reynolds, R Schulz, R Weehuizen, 10.1016/j.jagp.2013.01.058Am J Geriatr Psychiatry. 22Lokkerbol J, Adema D, Cuijpers P, Reynolds CF, Schulz R, Weehuizen R, et al. Improving the cost-effectiveness of a healthcare system for depressive disorders by implementing telemedicine: a health economic modeling study. Am J Geriatr Psychiatry (2014) 22:253-62. doi:10.1016/j.jagp.2013. 01.058

Internetbased cognitive behavioral therapy for insomnia: a health economic evaluation. H Thiart, D D Ebert, D Lehr, S Nobis, C Buntrock, M Berking, 10.5665/sleep.6152Sleep. 3910Thiart H, Ebert DD, Lehr D, Nobis S, Buntrock C, Berking M, et al. Internet- based cognitive behavioral therapy for insomnia: a health economic evalua- tion. Sleep (2016) 39(10):1769-78. doi:10.5665/sleep.6152

Consensus statement on defining and measuring negative effects of Internet interventions. A Rozental, G Andersson, J Boettcher, D D Ebert, P Cuijpers, C Knaevelsrud, 10.1016/j.invent.2014.02.001Internet Interv. 1Rozental A, Andersson G, Boettcher J, Ebert DD, Cuijpers P, Knaevelsrud C, et al. Consensus statement on defining and measuring negative effects of Internet interventions. Internet Interv (2014) 1:12-9. doi:10.1016/j.invent.2014.02.001

A mood management intervention in an Internet stop smoking randomized controlled trial does not prevent depression: a cautionary tale. S M Schueller, E J Pérez-Stable, R F Muñoz, 10.1177/2167702613484717Clin Psychol Sci. 1Schueller SM, Pérez-Stable EJ, Muñoz RF. A mood management inter- vention in an Internet stop smoking randomized controlled trial does not prevent depression: a cautionary tale. Clin Psychol Sci (2013) 1:401-12. doi:10.1177/2167702613484717

Selection of intervention components in an Internet stop smoking participant preference trial: beyond randomized controlled trials. S M Schueller, Y Leykin, E J Pérez-Stable, R F Muñoz, 10.1016/j.psychres.2012.08.030Psychiatry Res. 205Schueller SM, Leykin Y, Pérez-Stable EJ, Muñoz RF. Selection of interven- tion components in an Internet stop smoking participant preference trial: beyond randomized controlled trials. Psychiatry Res (2013) 205:159-64. doi:10.1016/j.psychres.2012.08.030

Just-in-time adaptive interventions (JITAIs) in mobile health: key components and design principles for ongoing health behavior support. Nahum-Shani I Smith, S N Spring, B J Collins, L M Witkiewitz, K Tewari, A , Nahum-Shani I, Smith SN, Spring BJ, Collins LM, Witkiewitz K, Tewari A, et al. Just-in-time adaptive interventions (JITAIs) in mobile health: key components and design principles for ongoing health behavior support.

. 10.1007/S12160-016-9830-8Ann Behav Med. Ann Behav Med (2016):1-17. doi:10.1007/S12160-016-9830-8

Prevention of major depression. R F Muñoz, P Cuijpers, F Smit, A Z Barrera, Y Leykin, 10.1146/annurev-clinpsy-033109-132040doi:10.1146/ annurev-clinpsy-033109-132040Annu Rev Clin Psychol. 6Muñoz RF, Cuijpers P, Smit F, Barrera AZ, Leykin Y. Prevention of major depression. Annu Rev Clin Psychol (2010) 6:181-212. doi:10.1146/ annurev-clinpsy-033109-132040

A prediction algorithm for first onset of major depression in the general population: development and validation. J Wang, J Sareen, S Patten, J Bolton, N Schmitz, A Birney, 10.1136/jech-2013-202845J Epidemiol Community Health. 68Wang J, Sareen J, Patten S, Bolton J, Schmitz N, Birney A. A prediction algorithm for first onset of major depression in the general population: devel- opment and validation. J Epidemiol Community Health (2014) 68:418-24. doi:10.1136/jech-2013-202845

External validation of the international risk prediction algorithm for major depressive episode in the US general population: the PredictD-US study. Y T Nigatu, Y Liu, J Wang, 10.1186/s12888-016-0971-xdoi:10.1186/ s12888-016-0971-xBMC Psychiatry. 16256Nigatu YT, Liu Y, Wang J. External validation of the international risk prediction algorithm for major depressive episode in the US general popu- lation: the PredictD-US study. BMC Psychiatry (2016) 16:256. doi:10.1186/ s12888-016-0971-x

An international risk prediction algorithm for the onset of generalized anxiety and panic syndromes in general practice attendees: predictA. M King, C Bottomley, J A Bellón-Saameño, F Torres-Gonzalez, I Švab, J Rifel, 10.1017/S0033291710002400Psychol Med. 41King M, Bottomley C, Bellón-Saameño JA, Torres-Gonzalez F, Švab I, Rifel J, et al. An international risk prediction algorithm for the onset of generalized anxiety and panic syndromes in general practice attendees: predictA. Psychol Med (2011) 41:1625-39. doi:10.1017/S0033291710002400

Development and validation of a risk-prediction algorithm for the recurrence of panic disorder. Y Liu, J Sareen, J Bolton, J Wang, 10.1002/da.22359Depress Anxiety. 32Liu Y, Sareen J, Bolton J, Wang J. Development and validation of a risk-pre- diction algorithm for the recurrence of panic disorder. Depress Anxiety (2015) 32:341-8. doi:10.1002/da.22359

Testing a machine-learning algorithm to predict the persistence and severity of major depressive disorder from baseline self-reports. R C Kessler, H M Van Loo, K J Wardenaar, R M Bossarte, L A Brenner, T Cai, 10.1038/mp.2015.198Mol Psychiatry. 2110Kessler RC, van Loo HM, Wardenaar KJ, Bossarte RM, Brenner LA, Cai T, et al. Testing a machine-learning algorithm to predict the persistence and severity of major depressive disorder from baseline self-reports. Mol Psychiatry (2016) 21(10):1366-71. doi:10.1038/mp.2015.198

Using patient self-reports to study heterogeneity of treatment effects in major depressive disorder. R C Kessler, H M Van Loo, K J Wardenaar, R M Bossarte, L A Brenner, D D Ebert, 10.1017/S2045796016000020Epidemiol Psychiatr Sci. 261Kessler RC, Van Loo HM, Wardenaar KJ, Bossarte RM, Brenner LA, Ebert DD, et al. Using patient self-reports to study heterogeneity of treat- ment effects in major depressive disorder. Epidemiol Psychiatr Sci (2017) 26(1):22-36. doi:10.1017/S2045796016000020

Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. C L Hyde, M W Nagle, C Tian, X Chen, S A Paciga, J R Wendland, 10.1038/ng.3623doi:10.1038/ ng.3623Nat Genet. 48Hyde CL, Nagle MW, Tian C, Chen X, Paciga SA, Wendland JR, et al. Identification of 15 genetic loci associated with risk of major depression in individuals of European descent. Nat Genet (2016) 48:1031-6. doi:10.1038/ ng.3623

The delivery of public health interventions via the Internet: actualizing their potential. G G Bennett, R E Glasgow, 10.1146/annurev.publhealth.031308.100235Annu Rev Public Health. 30Bennett GG, Glasgow RE. The delivery of public health interventions via the Internet: actualizing their potential. Annu Rev Public Health (2009) 30:273-92. doi:10.1146/annurev.publhealth.031308.100235

Impact of an acceptance facilitating intervention on diabetes patients' acceptance of Internet-based interventions for depression: a randomized controlled trial. H Baumeister, L Nowoczin, J Lin, H Seifferth, J Seufert, K Laubner, 10.1016/j.diabres.2014.04.031doi:10.1016/j. diabres.2014.04.031Diabetes Res Clin Pract. 105Baumeister H, Nowoczin L, Lin J, Seifferth H, Seufert J, Laubner K, et al. Impact of an acceptance facilitating intervention on diabetes patients' acceptance of Internet-based interventions for depression: a randomized controlled trial. Diabetes Res Clin Pract (2014) 105:30-9. doi:10.1016/j. diabres.2014.04.031

Increasing the acceptance of Internet-based mental health interventions in primary care patients with depressive symptoms. A randomized controlled trial. D D Ebert, M Berking, P Cuijpers, D Lehr, M Pörtner, H Baumeister, 10.1016/j.jad.2015.01.056J Affect Disord. 176Ebert DD, Berking M, Cuijpers P, Lehr D, Pörtner M, Baumeister H. Increasing the acceptance of Internet-based mental health interventions in primary care patients with depressive symptoms. A randomized controlled trial. J Affect Disord (2015) 176:9-17. doi:10.1016/j.jad.2015.01.056

Impact of an acceptance facilitating intervention on patients' acceptance of Internetbased pain interventions -a randomised controlled trial. H Baumeister, H Seifferth, J Lin, L Nowoczin, M Lüking, D D Ebert, 10.1097/AJP.0000000000000118Clin J Pain. 6Baumeister H, Seifferth H, Lin J, Nowoczin L, Lüking M, Ebert DD. Impact of an acceptance facilitating intervention on patients' acceptance of Internet- based pain interventions -a randomised controlled trial. Clin J Pain (2015) 31(6):528-35. doi:10.1097/AJP.0000000000000118

Effectiveness and cost-effectiveness of school-based dissemination strategies of an Internet-based program for the prevention and early intervention in eating disorders: a randomized trial. M Moessner, C Minarik, F Ozer, S Bauer, 10.1007/s11121-015-0619-yPrev Sci. 17Moessner M, Minarik C, Ozer F, Bauer S. Effectiveness and cost-effectiveness of school-based dissemination strategies of an Internet-based program for the prevention and early intervention in eating disorders: a randomized trial. Prev Sci (2016) 17:306-13. doi:10.1007/s11121-015-0619-y