Advancements in machine learning have minimized the gap of variation between human and algorithm composed music. This paper realizes a music generation system using evolutionary algorithms. The music generation is fully automated with no requirement of human intervention. Multiple music sample from a single dataset were used to the neural network. Software has been constructed to exhibit the results over various datasets. The proposed model is based on recurrent neural network with the input layer represents a measure at time T, and the output layer represents the measure at time T+1. The approach results in generation of new music composition by the system. Composition rules are used as constraints to evaluate the melodies generated by the novel neural network. Thus, the results are expected to evolve to satisfy the defined constraints. The proposed system of work would be capable of music generation without human intervention


Product design plays an important role within the overall process of innovation. It is through design that ideas and demands from the market are expressed in material form, and translated into hardware, thus allowing products to be introduced into the competitive environment. This article presents the result of a survey on product design capability, conducted in Paraiba state, North-east Brazil. It argues that this important aspect of innovation has been neglected in the development literature. Recognizing this innovative potential is crucial to the development of both urban and rural small manufacturing enterprises.


Background and Objectives: Pseudomonas aeruginosa is an opportunistic pathogen resistant to various antibiotics. The aim of the present study was to study resistant patterns in clinical isolates of P. aeruginosa, classify them into pandrug resistance (PDR), extensive drug resistance (XDR) and multidrug resistance (MDR) groups, and identify extended-spectrum β-lactamase (ESBL)-positive isolates using the phenotypic and genotypic methods. Methods: This cross-sectional study was conducted on 161 P. aeruginosa isolates collected from the city of Isfahan, Iran. Antibiotic susceptibility tests were performed using 11 antimicrobial agents. ESBL-positive strains were identified using the phenotypic and genotypic methods. Results: The highest level of antibiotic resistance was observed against ceftazidime (77.64%). None of the isolates was resistant to polymyxin B. In the phenotypic method, 64 isolates (39.75%) were found as ESLB-positive, whereas 132 isolates (81.98%) were ESBL-positive in the genotypic method. The number of ESBLpositive isolates in the genotypic method was significantly higher than in the phenotypic method. The frequency of XDR and MDR isolates was 50.93% and 27.32%, respectively. None of the isolates was PDR. The frequency of the blaTEM gene was significantly higher than other genes (P<0.0001). Conclusion: It was revealed that the genotypic method was much more accurate in identifying ESBL-positive strains than the phenotypic method. Therefore, use of the molecular method may increase the chance of successful treatment with antibiotics of the β-lactam family.


Abstract : For the past two decades in the United States, blast sounds and sonic booms both have been assessed using C weighted day and night average sound level. Based almost exclusively on blast sound research, a new method which replaces the C weighted day and night average sound level recently has been recommended, reviewed, and incorporated into a new American National Standard. As in the previous method, the new method includes and assesses sonic boom sounds in a like manner to blast sounds. However, while available evidence suggested that in an indoor setting sonic boom could be treated in a similar fashion to blast sounds, experimental evidence was lacking. To provide the lacking comparison data, this study tested the responses of subjects to sonic booms to determine if they were consistent with the previous blast response data presented by Schomer in 1994, since these data formed the basis for the new method. A key factor in the design of this study was the presentation of real blasts and booms to subjects situated in real structures in the field. The new data resulting from this study show good general agreement with the previous data.


The wild Swans was draw materials from the folklore,Andersen has developed detail depicting,has enriched the personage character and story line,and has laid stress on the emotion strength,the tradition folktale has been developed thereby to the extreme form,so gains brand-new modern children's stories characteristic.


Summary form only given. The shaped reflector is recognized as a vital technology in the field of satellite antennas. The shaped reflector concept requires only a single feed to achieve a required contoured beam and due to its simplicity, shaped reflector contoured beam antennas are still the most requested antennas for telecoms in the satellite industry today. With the increasing interest in the use of large shaped reflector deployable antennas operating at high frequencies and with very demanding gain and isolation requirements, the demands on reflector surface accuracy becomes a key factor in the success of a space program. Thermal effects usually result in important distortions on the surface of the shaped reflector and consequently in the degradation of the antenna pattern (Y. Rahmat-Samii, IEEE Aerospace and Electric Systems Mag., Vol. 6, Issue 6), especially in those areas of the coverage that require isolation. Surface distortions due to manufacturing as well can affect the antenna behavior, by causing antenna depointing and an increase in the side lobe levels. Periodic deformations (e.g. due to the supporting structure or to surface segmentation) give rise to specific sidelobe patterns linked to their spatial frequencies. Random surface errors as well, even if of relatively small amplitude, can be assumed to generally reduce the peak gain and increase sidelobes. The behavior of the distorted reflector can be improved by using different techniques to compensate the reflector distortions (B. Gonzalez-Valdes, et Al., EUCAP 2010 Proceedings). Sometimes however, distortions appear following a non predictable pattern which cannot be accounted for at the time of the antenna design procedure. In this case, which is quite common especially for manufacturing surface errors, distortion compensation techniques have a very limited applicability and don't bring a massive improvement in the distorted antenna behavior. The objective of this study is then to systematically investigate the surface distortions due to manufacturing with the aim of understanding which physical surface features are causing the most important antenna pattern distortions, in order to build some guidelines for the surface design and for manufacturing. An as-build surface often presents random errors on top of the desired shape, but these distortions are usually a combination of a few main shape distortions that can be modeled and applied to a nominal shaped surface. Thereby, the RF analysis of a modeled distorted surface can help to understand which contributions are to be avoided and can therefore lead the antenna design to be more stable and resistant to manufacturing errors.


The fuzzy logic technique has been widely employed in different applications .It has the capability of mimicking the human mind to adequately apply modes of reasoning, which are approximate rather than exact. In this paper, one of the fuzzy logic challenges, related to learning capabilities, is handled by proposing an approach that auto generates fuzzy models using previous observations. This approach involves generating membership functions and fuzzy rules. In other words, this paper shows how to use fuzzy logic as a machine learning algorithm, based on a training dataset. The approach is based on iteration. In each iteration, some parameters are changed to generate fuzzy rules. The iteration process will stop once the error goes below a specified value. Results show that the fuzzy system, based on rules generated using the proposed approach, has achieved a high level of accuracy.


Kaolinite intercalation compounds were prepared by intercalating fatty acids and quaternary ammonium salts into kaolinite layers, using methanol-grafted kaolinite as the precursor. Meanwhile, massive lamellas were exfoliated during the intercalation process. The interlayer structure, chemical bonding and morphology of kaolinite before and after intercalation were characterized in detail. As the alkyl chain length increases, the basal spacing of kaolinite increases gradually. The morphology analysis indicated that the ionic type of intercalation agent has a more important influence on the morphology change of kaolinite than their alkyl chain length. The initial kaolinite layers were mostly transformed into nanoscrolls in the product intercalated with stearyl trimethyl ammonium chloride (STAC). The present study demonstrates the arrangement model of intercalated molecules between kaolinite layers using X-ray diffraction (XRD) in conjunction with Fourier transform infrared (FTIR) and stereochemical calculation. On the basis of a probed arrangement model, the mechanism of effect of the alkyl chain length and ionic type of intercalation agent on the morphology of exfoliated kaolinite is suggested.


Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose To provide an overview of compounding under sections 503A and 503B of the Federal Food, Drug, and Cosmetic Act, and to describe the pharmacist's role within the US Food and Drug Administration's (FDA's) Compounding Incidents Program, whose efforts are aimed at protecting the public against poor-quality compounded drugs through surveillance, review and response to adverse events and complaints. Summary Compounded drugs may serve an important medical need for patients who cannot be treated with medications approved by FDA; however, compounded drugs are not approved by FDA and are not subject to premarket review for safety, efficacy, or manufacturing quality; thus, they may pose safety risks to patients. Prompt reporting of adverse events or complaints related to compounding is important in identifying these risks and implementing safeguards to protect the public. FDA's Compounding Incidents Program consists of a team of pharmacists dedicated to the surveillance and review of adverse events and complaints and follow-up actions related to safety risks associated with compounded drugs. Pharmacists are a vital component of FDA's Compounding Incidents Program, utilizing their clinical skill set and regulatory knowledge to review and act on safety issues that affect public health. Conclusion As FDA continues to expand the Compounding Incidents Program and its efforts to protect the public against poor-quality compounded drugs, we encourage the continued submission of adverse event reports by healthcare professionals and consumers to FDA's MedWatch reporting system in addition to adverse event reporting compliance by outsourcing facilities.


The application of Bayesian inference for the purpose of model selection is very popular nowadays. In this framework, models are compared through their marginal likelihoods, or their quotients, called Bayes factors. However, marginal likelihoods depend on the prior choice. For model selection, even diffuse priors can be actually very informative, unlike for the parameter estimation problem. Furthermore, when the prior is improper, the marginal likelihood of the corresponding model is undetermined. In this work, we discuss the issue of prior sensitivity of the marginal likelihood and its role in model selection. We also comment on the use of uninformative priors, which are very common choices in practice. Several practical suggestions are discussed and many possible solutions, proposed in the literature, to design objective priors for model selection are described. Some of them also allow the use of improper priors. The connection between the marginal likelihood approach and the well‐known information criteria is also presented. We describe the main issues and possible solutions by illustrative numerical examples, providing also some related code. One of them involving a real‐world application on exoplanet detection.


We have read the report by Ramos et al. (1) in the Journal with great interest and excitement. The researchers have investigated patients from age 35 to 85 years with an ankle-brachial index (ABI) of 0.95 and without clinically recognized cardiovascular disease (CVD). They have categorized the patients as statin nonusers or new-users (first prescription or prescribed after at least 6 months) according to the beginning of statin treatment. The authors also stated that statin therapy was associated with a reduction in major adverse cardiac events and all-cause mortality among participants without clinical CVD, but with asymptomatic peripheral arterial disease (PAD), regardless of its low CVD risk. There are some issues that should be regarded in the interpretation of the study results. There are several studies demonstrating a close relation between CHA2DS2-VASc scores and PAD. In the study by Violi et al. (2), PAD and atrial fibrillation was found to be a potentially dangerous combination. They found that comparison of vascular prevalence as assessed by CHA2DS2-VASc score and/ or ABI #0.90 is of interest to define the potentially positive impact of measuring ABI in the management of patients with nonvalvular atrial fibrillation. In addition, the authors stated that "If ABI #0.90 was encompassed in the definition of vascular disease of CHA2DS2-VASc score, the prevalence of vascular disease increased in every risk class." This issue should be clarified to correct the interpretation of the study results. Lane et al. (3), in the clinician update "Use of the CHA2DS2-VASc and HAS-BLED Scores to Aid Decision Making for Thromboprophylaxis in Nonvalvular Atrial Fibrillation," stated that use of risk schemas such as CHA2DS2-VASc and HAS-BLED can help to inform the choice of antithrombotic agent and the management strategy. Discussion of these risks with patients is essential, and this discussion over the patient's lifetime and treatment course plays a significant role in reducing any other possible events. The CHADS2 score has been recently refined with the CHA2DS2-VASc score, which includes vascular disease as documented by a history of acute myocardial infarction, symptomatic PAD, or detection of atherosclerotic plaque in the aortic arch (4). On the other hand, there are some doubts about the anticoagulation regime of the patients of this study. In this study, about 6% of patients had a diagnosis of atrial fibrillation. Presence of risk factors such as hypertension, diabetes, coronary artery disease, and old age in the study population is associated with thromboembolism, bleeding, and high mortality risk. Therefore, CHADS2 or CHA2DS2-VASc (5) scores should have been calculated and possible effects should have been explained before discussing the study results.


Objective To explore the distant parts of the brain of postoperative epidural hematoma of the mechanism and its clinical significance.Methods We collected 20 cases of postoperative distant parts of the brain in patients with epidural hematoma,have been checked at diagnosis.After the tumor size,location location,distant parts of the epidural hematoma size and location of the site,time of occurrence of the statistics.Results distant hematoma occurred in 5 cases the average size of 30 mm×50 mm,the amount of the top left,recovered;including four cases of distant hematoma occurred an average size of 40 mm×80 mm,right parietal occipital,death;5 cases occurrence of distant hematoma occurs the average size of 40 mm×50 mm,automatic discharge;6 patients had distant hematoma occurred,the average size of 20 mm×60 mm,left parietal occipital,left frontal recovery.Combination of literature review,to explore its mechanism and clinical significance of its possible causes and surgical considerations.Conclusion Brain surgery to fill the cavity should be timely,good drainage work,and timely processing of early complications.


Abstract Throughout 2010, Australian SBS television viewers had the opportunity to enjoy the first episodes of Luke Nguyen's Vietnam, a cooking-while-travelling series, presented by Vietnamese-Australian chief chef of the Red Lantern Restaurant in Sydney. With a distinct Australian accent, he effortlessly guided audiences through the beautiful Vietnamese landscape and the exotic delights of its cuisine; charming viewers into learning about a Vietnam very different to the one universally presented through news reports of the Vietnam War.


Many researchers having commented on the links between information technology and organizational change have reached conflicting conclusions about the causal relationship linking these two dimensions. In this article, we approach this relationship from a new angle by developing a scorecard allowing measurement of more specific dimensions of Computerization and Centralization. To develop this management tool called CSS (Computerization and Centralization Scorecard), we relied on research conducted within the Swiss public administrations, especially regarding the digitization of registers of persons. The development of this tool followed a first descriptive analysis model developed to treat semi-structured interviews we conducted with various stakeholders in our research.


A bidirectional nonreciprocal wavelength-interleaving filter based on an optically coherent high birefringence fiber transversal filter structure is demonstrated. Stable, low loss, low dispersion, and high isolation operation is demonstrated with reconfigurable transfer characteristics for interleaved channel spacing of 0.8 nm.


Pulsatile tinnitus is a rare yet potentially disabling symptom that can have either vascular or nonvascular etiologies. A recently described vascular cause is an aneurysm of dural venous sinuses. To our knowledge, eight of such cases have been published, five of which were treated surgically and three by endovascular approach. We describe one additional case treated successfully by endovascular coiling and review the current data on this subject.


the college students of "generation after 90's" raise a series of management problems when they have internship in the hotels.In order to improve the quality of internship,the article suggests the hotels carry out humane managements,and give the trainees systematic training;the colleges should actively explore new paths on how to make the training management mechanism perfect.


The influence of the annual bean plant Kummerowia stipulacea seed deep freezing in the liquid nitrogen on their germination is studied by the authors. The morphological characteristic comparative analysis of the plants grown from the frozen seeds is conducted.


Thyroid hormone autoantibody (THAb) is a common antibody in autoimmune disease and can interfere with the detection of thyroid hormone (TH). There was no research reporting the prevalence of THAb in Chinese and the rate of THAb interfering with TH detection.


A load distribution method of on line process control on tandem cold rolling mill is introduced. The initial load distribution mode and ratio are queried from database, and a single object distribution function is built. Using simplified Newton-Raphson method, the nonlinear equations can be solved to get load distribution. Then according to the rolled strip length on the No. 5 stand, the correction of load distribution is carried out, in order to avoid the slip of strip. The limitation of correction will be checked and be corrected if over-limit is occurred, then the final load distribution can be got. This method has been used on line with good effect.


Monotone systems are dynamical systems whose solutions preserve an ordering relative to the initial data. This study develops a set-point regulation approach for a certain class of systems subject to input and state constraints which leads to closed-loop strongly monotone systems. The proposed method gives static output feedback controllers that guarantee the convergence of generic bounded solutions to the desired set-point, satisfy the constraints and preserve the control performance under the input saturation. Although such a set-point regulation problem is too challenging for general non-linear systems, the proposed approach finds some well-organised controllers that satisfy the mentioned control objectives. To investigate the applicability of the proposed control technique, the authors exploit a model of cancer tumour growth in an unhealthy tissue. The medication (control) intends to take solutions to the healthy state through a constrained chemotherapy protocol. The authors present a full dynamical analysis for this system.


A device has been constructed which mimics the geometry and operating conditions of a tube/tube support plate crevice in a pressurized water reactor (PWR) steam generator. This apparatus is instrumented to measure the tube wall temperature in the crevice, the free span and crevice potentials, and the crevice chemistry. Results have been obtained for 280 C NaOH solutions continuously pumped through the autoclave under several crevice temperature and power levels. Changes in tube wall temperature changes after superheat was applied indicated that various depths in the crevice underwent several thermal-hydraulic transitions before reaching equilibrium conditions. The lower third of the crevice was wetted at equilibrium. Sodium hydroxide concentrated at rates near the theoretical limit until equilibrium was reached at concentration factors in the 10{sup 4} range.


We read with interest a case report by Maglie et al.1 , published in the journal of Clinical and Experimental Dermatology. The authors reported their experience about a co-associated pemphigus vulgaris (PV) and acquired heamophilia A (AHA) in a 66-year-old male patient with unremarkable systemic diseases. The patient demised due to myocardial infacrtion (MI) shortly after diagnosis. The authors raised a speculation that prednisone tapering triggered the clinical manifestation of AHA.


In order to utilize the merits of true color, high resolution, mature technologies of CRT and overcome its big bulk and heavy body, a novel deflection yoke, which is composed of two main and two assistant cylindrical yokes, was proposed. The thickness of the CRT made of this novel deflection yoke can be decreased quite a bit. This CRT achieves large deflection angle while keeping the fine image quality. The experimental results show that the largest deflection angle of the electron beams may exceed 126°, and that this CRT has a fine light spot test result. The focusing characteristics of the electron beams are also improved.


Abstact: to encourage student on critical thinking ability in biology. This research had been carried out to investigate the influence of PBL through learning study PQ4R about critical thinking ability. This research design used was quasi experiment. This type of research is to experiment with Pre-test and Post-test Control Group Design, using one class each of control and experiment. Reseach the conclusions are the Learning Strategy used has great influence on the critical thinking ability well in biology. Based on the research result, it is suggested to the educator or teacher to apply learning strategy that emphasize on the critical thinking development to promote the self regulated learners. Normal 0 false false false EN-US X-NONE X-NONE /* Style Definitions */
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Aligarh Muslim University has a long history of academic excellence. It has produced many eminent personalities in different fields. The Central Library of the University has given the needed Phillip to the excellent record of the University. An assessment of the library resources and services by the researchers has been made and presented in this article.


We report the development of terahertz intersubband photodetectors based on GaN/AlGaN quantum wells, covering the frequency range that is fundamentally inaccessible to existing III-V semiconductor devices due to Reststrahlen absorption. Two different approaches have been employed to mitigate the deleterious effects of the intrinsic polarization fields of nitride heterostructures: the use of suitably designed double-step quantum wells, and epitaxial growth on semipolar GaN substrates. Promising results are obtained with both approaches, which could be extended to other device applications as a way to utilize the intrinsic advantages of nitride semiconductors for THz intersubband optoelectronics.


The optical window located in the front of naval gun TV guided projectile bears the complex load in the process of firing.It is difficult to calculate the optical window's stress value of the numerical analytic solution.Using the general finite element software ANSYS,the optical window's finite element model is established,mechanical calculation model is simplified,the stress distribution cloud of the optical window is got when its bearing the maximum bore pressure.Based on the mechanical properties of material,it can check the strength of the optical window and provide the theoretical basis of selecting material and optimizing the structure in design work.


Introduction:
 In patients suffering from hypertension, the presence of concurrent atrial fibrillation tends to escalate the risk of severe conditions and worsen outcomes. This study, aimed to delve into the impact that a simultaneous diagnosis of atrial fibrillation can have on patients admitted for hypertensive emergencies during the initial year of the COVID-19 pandemic.

 Methods:
 We examined data from the 2020 National Inpatient Sample to identify patients primarily admitted due to a hypertensive emergency. We used ICD-10 codes to distinguish between those with and without concurrent atrial fibrillation. We employed logistic and linear regression analyses and accounted for potential confounders. We deemed the results as statistically significant when the 2-tailed p-value was less than 0.05.

 Results:
 During 2020, there were a total of 1,221,535 admissions for hypertensive emergencies. Notably, 470,440 (38.5%), involved patients concurrently diagnosed with atrial fibrillation. After adjusting for variables such as age, race, gender, the size and geographic location of the hospital, insurance coverage, income level, and existing comorbidities, patients hospitalized for hypertensive emergencies, who were also diagnosed with atrial fibrillation, demonstrated an elevated risk of in-hospital mortality (aOR 1.25, 95% CI 1.18-1.32). This patient group was also more likely to require the initiation of mechanical ventilation (aOR 1.06, 95% CI 1.03-1.09), vasopressor therapy (aOR 1.71, 95% CI 1.52-1.92), and mechanical circulatory support (aOR 1.71, 95% CI 1.32-2.21). Intriguingly, despite the increased risks in these areas, these patients displayed a reduced rate of hemodialysis initiation (aOR 0.82, 95% CI 0.79-0.86).

 Conclusion:
 Atrial fibrillation seemingly has a critical influence on the in-hospital outcomes of patients admitted for hypertensive emergencies, generally leading to more unfavorable results. Given the anticipated increased prevalence of atrial fibrillation in an aging population, understanding its pathophysiology and potential contribution to the complexity of diseases in patients with severe hypertension represents a crucial area for further investigation.


The use of biomass as gas turbine combined cycle fuels is broadly seen as one of the alternatives to diminish greenhouse gas emissions, mainly CO2 , due to the efficiency delivered by such systems and the renewable characteristic of biomass itself. Integrated gasification cycles, BIGGT, are the current technology available; however the gasification system severely penalizes the power plant in terms of efficiency and demands modifications in the engine to accommodate the large fuel mass flow. This gives an opportunity to improvements in the current technologies and implementation of new ones. This paper intends to analyze new alternatives to the use of solid fuels in gas turbines, from the economical point of view, through the use of external combustion, EFGT, discussing its advantages and limitations over the current technology. The results show that both EFGT and BIGGT technologies are economically competitive with the current natural gas fired gas turbines. However, BIGGT power plants are still in pilot scale and the EFGT plants need further technological development. Thermodynamically speaking, the inherently recuperative characteristic of the EFGT gas turbine engine makes it well suited to the biomass market. The thermal efficiency of this cycle is higher than the BIGGT system. Furthermore, its fuel flexibility and negligible pre-treatmet is another advantage that makes it an interesting option for the Brazilian market.Copyright © 2004 by ASME


The lymphatic drainage of the anal canal distal to the anal valves has been studied. Evans blue dye was employed in 20 patients in order to note lymphatic drainage occurring other than to the inguinal nodes. Lymphatic drainage was observed along the course of the inferior, middle and superior rectal and the inferior mesenteric vessels.


Purpose of the study: This study was designed to assess the role of interpersonal and Informational Justice in the purview of teaching faculty's job satisfaction. Methodology: A cross-sectional and quantitative research method was carried out in three randomly selected universities of Khyber Pakhtunkhwa, Pakistan i.e. Bacha Khan University, University of Malakand, and the University of Swat. A well-structured questionnaire was used for data collection from 217 sampled respondents (employees) for primary data collection. Further, the researchers analyzed the data through descriptive and inferential statistics, i.e. frequency, percentage, correlation, and indexation of the study variables, namely dependent (job satisfaction) and independent (Interpersonal and Informational Justice), respectively. Principal Findings: Regarding the demographic sketch of the sampled respondents, the study found that the majority of the respondents were male, having the age group from 31-40 years with the collaboration of 5-10 year experiences of teaching at the university level. Further, as per the correlation test statistics at bivariate analysis between the Interpersonal and Informational Justice with job satisfaction was found significant with strong correlation (P≤0.05; 0.860) respectively. Applications of this study: The government and administration should take positive steps to provide a good working environment to establish their trust by expanding cooperation towards employees, exploration of benefits, strengthening relationships with each other, and encouragement of open communication that can stimulate and encourage an exchange of view between faculty and administration was put forward some of the recommendations in light of the study findings. Novelty/Originality of this study: This research comes under the domain of Sociology of organization and sociology of work through the perceptional-based endeavor.


Abstract : Several ground collision avoidance systems (GCAS) have been developed to warn the pilot of a potential collision with the terrain is some action is not taken. All current systems have shortcomings pertaining to the sensors that are used and the recovery maneuver that is flown. The USAF is evaluating the potential of digital terrain databases for onboard navigation and terrain avoidance in combat aircraft. The purpose of this thesis was to develop a control system for performing terrain avoidance using a simulated terrain database. This study was conducted for an F-16 aircraft in level flight at 0.6 Mach and sea level conditions. A state-space model of the aircraft and its flight control system was developed using aircraft control derivatives, an F-16 control law diagram, and traditional linearization techniques on the aircraft equations of motion. A control system for implementing terrain avoidance was derived based on the look-ahead capability of the terrain database. Control system response was evaluated using a simulated terrain obstacle and various look-ahead distances on the terrain database. Results indicated that a 1200 foot, or roughly 1.8 second, look-ahead distance provided good improvement in terrain avoidance capabilities for the F-16 compared to looking strictly downward from the aircraft for terrain information. Theses.


The work presented in this paper is part of a research project conducted at FPInnovations Forintek with objective to quantify the seismic behaviour of braced timber frames with timber riveted connections. Results are presented from monotonic and cyclic tests conducted on diagonal brace members with riveted connections on both ends. Based on the results from the cyclic tests, non-linear analytical models were developed for diagonal brace members as well as for the entire braced frames. Using the DRAIN 2DX computer program, a series of non-linear static and time history dynamic analyses were performed. The acceleration records used for the analyses were chosen to satisfy the seismic zonal parameters for Vancouver, BC, Canada. Parameters that influence the seismic behaviour of braced timber frames are discussed, including estimates of the newly introduced ductility-based force modification factors (Rd factors) in the 2005 edition of the National Building Code of Canada (NBCC). Finally, the paper provides some guidelines on implementation of capacity design procedures for braced timber frames.


In this paper, we propose a class of Bayes estimators for the covariance matrix of graphical Gaussian models Markov with respect to a decomposable graph G. Working with the WPG family defined by [27] we derive closed-form expressions for Bayes estimators under the entropy and squared-error losses. The WPG family includes the classical inverse of the hyper inverse Wishart but has many more shape parameters, thus allowing for flexibility in differentially shrinking various parts of the covariance matrix. Moreover, using this family avoids recourse to MCMC, often infeasible in high-dimensional problems. We illustrate the performance of our estimators through a collection of numerical examples where we explore frequentist risk properties and the efficacy of graphs in the estimation of high-dimensional covariance structures.


In this paper we present experimental findings of both the heart and respiratory rate of a static person using pulse based radar and we present a simulated system for tracking a moving person based on respiratory motion in an indoor environment. In the simulation the subject moves in one dimension and the system is able to track the subject by detecting their respiration. The presented system contains a transmitter, receiver, and channel model section, in addition to control section which controls the transceiver and processes the received data. The Gaussian monocycle is considered as transmitted pulse and the channel is modeled based on multipath delay and attenuation. The system first removes the person's movement using correlation between each received wave form. Then, the respiration rate of the target is calculated. Finally, the respiration rate is used to track the specific target in an indoor environment. The system is effective for accurate tracking of subjects walking in one direction, under 10 m/s. The algorithm for finding heart and respiratory rates is the same for both real and simulated environments.


In this paper, enhancement of photoluminescence (PL) intensity from InGaAs/GaAs quantum well (QW) caused by coupling effect of surface plasmon (SP) resonance generated by Au nanodisk arrays with QW emission is demonstrated experimentally. To increase the coupling efficiency, a thin layer of SiO2 is introduced between Au nanodisk and GaAs surface. To match SP wavelength with QW emission wavelength (945 nm), Au nanodisk arrays with periodicity of 290 nm, radius of 70 nm, and thickness of 10 nm is fabricated. 2.17-fold enhancement is observed.


For comparison effect of tow type aerobic exercises on alternations of LDL-c, HDL-c a skin fold; 30 male students selection randomly in Islamic Azad University - Dezful branch. Students division in tow groups. 1) Age M :22.7, Weigh M :66.3, Height M :174.7; exercise program inclusive :15 min warm up, 25 min running (5 set : slow running with 1 min walking ) with 65-85 percent of MHA and 10min cool down. 2) Age M : 23.8, Weigh M :78.4, Height M : 175.2; exercise plan include: Circle exercise (8 sections) with 65-85 percent if MHR and 10 min cool down. Measurement included percent of body fat and blood samples that tacked before exercise and after it. T-student was profit to analyze data and maximal level of significance for this study was set p≤0.05. The results of this research observed that one set periodic running don't significant effect on HDL-c. But did not significant LDL-c and sub skin fold. The results shown that one set aerobic exercise has more influence besides periodic running on Plasma Lipids.


To evaluate the correlation of clinical and urodynamic parameters with bladder vascular resistance before and after dutasteride treatment in patients with lower urinary tract symptoms associated with benign prostatic enlargement.


In this paper, a technique for wideband radar signatures analysis is developed which combines modified polarization decomposition with parametric modeling. Firstly, a modified polarization decomposition is proposed so that the electromagnetic scattering of a complex target can be decomposed into four components, representing typical scattering mechanisms. Then, the complex exponential (CE) model is used to extract the frequency dispersion feature for each scattering center, making it easier to classify the radar targets with different scattering structures. Numerical results are presented to demonstrate the usefulness of the proposed technique.


Using purpose-built original 2018 Japanese survey data, we estimate the financial behaviors and attitudes of households. We find that financial literacy plays an important and consistent role in financial decision-making. However, the actual behaviors are counter-intuitive: People with high financial literacy tend to take too many risks, overborrow, and hold naive financial attitudes; that is, financial literacy makes people daring and reckless in some financial aspects. By contrast, financially literate people are good at retirement planning and are indifferent to gambling. Preferences such as risk and loss aversions and discount factors, also have a role in financial choices.


This study investigates the use of biodiesel derived from Pangium Edule Reinw (Pangium biodiesel) and Cocos Nucifera (palm biodiesel) in diesel engines as alternative fuels. A direct injection (DI) diesel engine simulated via a thermodynamic cycle model for investigation. Thermodynamic and performance parameters and compared for diesel, Pangium biodiesel, and palm biodiesel fuels at two different states. The results displayed that Pangium biodiesel shows a relatively higher cylinder temperature and pressure compared to palm biodiesel and diesel fuel at a lower crank angle. It also means that 100 % biodiesel is capable of performing a smaller engine capacity compared to diesel fuel at similar injection conditions. The brake power declines about 8.1% and 8.3% at 3800 rpm, while brake specific fuel consumption increases about 8.7% and 9.4% at 1900 rpm for Pangium biodiesel and palm biodiesel, respectively. The engine performance for Pangium biodiesel and palm biodiesel significantly improve at the same equivalence ratio condition. However, a more amount of fuel is required, which is approximately 20.7% for palm biodiesel and 8.5% for Pangium biodiesel. The brake thermal efficiency for Pangium biodiesel and palm biodiesel is generally better than diesel fuel.


In order to improve the seating comfort of wheelchairs, the invention proposes a wheel chair (1; 101) comprising a frame (2; 102), with a seat (3; 103) comprising a seat portion (8) to sit on a person and a back portion (9 ), with wheels (4, 5, 6, 7; 104, 105, 106, 107) for rolling of the wheelchair (1; 101) and with a drive device (15; 115) for driving at least one of the wheels (4, 5; 104, 105) in front, wherein the seat (3) and the wheels (4, 5, 6, 7; 104, 105, 106, 107) on the frame (2; 102) are fixed, wherein the drive means (15; 115) is coupled to the seat part (8) and / or to the backrest part (9) mechanically in such a way that the seat part (8) and / or (with the backrest part of 9) (15 by means of the drive means; 115) (relative to the frame 2; 102) is displaceable to at least the buttocks on the seat (3) to move the seated person.


State, Society & Governance in Melanesia ssgm.bellschool.anu.edu.au The Australian Bureau of Meteorology has predicted an El Niño event in the Pacific Ocean later in 2015. Large El Niño events have previously caused severe disruptions to village food production in Papua New Guinea (PNG), resulting in widespread hardship and hunger. This In Brief considers the possible impacts of a 2015–16 El Niño and suggests what can be done to address them. Despite greatly improved monitoring of the Pacific Ocean, 'once an event is underway forecasting its duration and intensity are at best difficult' (US Drought Mitigation Center). Nevertheless, the US Climate Prediction Center says 'there is a greater than 90 per cent chance that El Niño will continue through Northern Hemisphere winter 2015–16 and around an 80 per cent chance it will last into early spring 2016' (9/7/2015). If an El Niño event occurs in 2015, there is no sure way of predicting the severity of drought, frosts, and food shortages in PNG. A 'warning' index created from an analysis of PNG rainfall data from 1890 to 2010 successfully predicted only 57 per cent of subsequent droughts (Cobon et al. 2015). Even with these uncertainties, it is advisable to prepare for the likely impacts of an El Niño event in PNG.


Orange yields were maintained and packout appeared to be improved over a four-year period following maintenance hedging and topping (done before excessive crowding occurred) in a mature Valencia citrus grove.


Abstract: Phylloblastia inexpectata Sérus., Coppins & Lücking is a newly described foliicolous lichen, known from England, Scotland, Southern Italy and Madeira. It is distinguished from similar and related species by the absence of isidia and the smaller size of its ascospores. Phylloblastia pocsii is reported from Papua New Guinea for the first time.


In February 1994,1 attended a meeting on oil activities in the Ecuadorian Amazon held at the headquarters of CONFENIEA (Confederacion de Nacionalidades Indfgenas de la Amazonia Ecuatoriana), the regional confederation of Amazonian Indians in Ecuador. This was one of the first forums in which lowland mestizo peasant and indigenous leaders throughout the region gathered to discuss petroleum development in the Ecuadorian Amazon (or Oriente as the area is called). Only three months earlier a Philadelphia law firm had filed a class-action lawsuit against Texaco Inc. in the New York federal court on behalf of Amazonian mestizo peasants and Indians. The meeting focused on the lawsuit. Members of the lowland Indian federation with whom I was working asked me, along with a Quito-based environmentalist, to take part in discussions. At one point, a mestizo leader turned to me (the supposed expert on the United States) and asked why Texaco Inc. thought it was not responsible for its Ecuadorian operations. As I attempted to explain the legal relationship between a parent company and its subsidiary, another leader interrupted: "Oh, it [Texaco's subsidiary] is a miembrillo that does what the company orders." Laughter immediately filled the room. Miembrillo, although meaning "a small appendage" or "little member" in Spanish, is also slang for penis in Ecuador. Without missing a beat, Sonia (a Quito-based environmental activist, single mother of two, and the only other female in the room) teased: 'Yes, but Texaco is more complex than el hombre. La compania has many miembrillos and at least it pretends that it's not associated with the ones that get it into trouble." The playful sparring had begun. "Well then," the mestizo leader jeered, "let's help it along. We've learned a bit from Lorena, haven't we? We'll just bobbittizcir la compania." This article explores the unanticipated connections that many Ecuadorians made in early 1994 between a class-action suit against Texaco Inc, and the Lorena Bobbitt affair. The transnational lawsuit filed on behalf of 30,000


Background. The fissures of Santorini have long been known as a gateway for disease to pass from the external auditory canal to the periparotid and neck spaces. Although anatomically understandable, description of disease that originates in the parotid gland and extends through the fissures to the external auditory canal is rare. This is, in fact ,the first presentation of such a patient at our institution in a previously untreated patient.


One common trend in switch-mode power supply, micro-processor, and digital circuit applications is to achieve reduced noise while operating at higher frequencies. In order to realize this, components with low Equivalent Series Resistance (ESR), high capacitance and high reliability are required. A new generation of Low ESR tantalum chip capacitors has been developed utilizing a low resistivity MnO2 electrolyte that enables very low component ESR. MnO2 technology provides excellent field performance, environmental stability and high electrical and thermal stress resistance in wide voltage range from four to thirty-five volts. The capacitors are designed for operation in temperatures up to 125°C.


All the hilltops of the city of Athens are occupied by the formation of "Tourkovounia" Limestones. Some of the most important monuments in the city and also many residential areas are founded on these formations. The world renowned monument of Acropolis, the ancient Supreme Court (Arios Pagos), and the Pnika are prime examples of monuments founded on these limestones. A detailed knowledge of the geotectonic data and geotechnical characteristics regarding these formations are clearly important for construction work in these areas. From the evaluation of engineering-geological maps and tectonic data, from both recent and older studies, it can be determined that these formations are intersected by faults, mainly normal, which in some locations have been subject to intensive karstic weathering. This weathering turns those faults into wide karstic fissures. The karstic voids formed by this mechanism are often 0.5 to 2 m wide and can be infilled or partially infilled with clay or stalagmitic materials. When the karstic fissures intersect the voids can get extremely wide and in some places the voids were up to 15m across. The influence of Karst structures on the geotechnical behaviour of the limestones is significant and this must be taken into account at design stage. This paper aims to present data regarding the engineering geological setting and properties of the Tourkovounia limestones. In particular, the paper presents data about the stress field that caused the main neotectonic structures, the distribution and the geotechnical characteristics of the karstic fissures, the orientation and the geometry of the joint sets and finally the geotechnical parameters of the limestones. Resume: Toutes les collines de la ville d'Athenes affleurent les calcaires de "Tourkovounia". Acropolis, Arios Pagos, et Pnika, des monuments tres connus ou monde entier, sont des exemples caracteristique, comme ils sont fondes sur ces calcaires. Ainsi, il est evident que la connaissance des donnees tectoniques et des caracteristiques geotechniques de ces calcaires est importante pour les projets des constructions. L'evaluation des cartes techniquo - geologiques et des donnees tectoniques derivees par des etudes precedentes, a donne que ces calcaires sont affectes par des failles normales en principe ou par endroit on peut observer une erosion karstique intense. La desagregation karstique intense transforme ces failles en ouvertures karstiques larges. Les dimensions de ces karsts formes par ce mecanisme, sont de 0.5m a 2m ou on peut trouver des stalagmites ou du materiel d'argile. Quand ces ouvertures karstiques se croisent les espaces vides karstiques deviennent tres larges et leurs dimensions par endroit depassent les 15m. C'est evident que l'influence de ces structures au comportement geotechnique des ces calcaires est grande et on doit en tenir compte aux projets de constructions. Le but de cet article est a presenter les donnees techniquo - geologiques des calcaires de Tourkovounia et plus precisement les tension neotectoniques, la distribution et les caracteristiques geotechniques des ouvertures karstiques, l'orientation et les parametres de groupe de diaclases paralleles, ainsi que les parametres technique - geologiques des calcaires.


For optimal sensitivity to low-mass dark matter candidates experiments like DAMIC-M employ skipper charged-coupled devices (CCDs) with detection threshold of just a few ionization charges. Ionization signals from small-angle Compton scatters of environmental \gammaγ-rays, an important component of the background in dark matter searches, must thus be characterized down to OO(10 eV) energy. Using a ^{241}241Am \gammaγ-ray source, we report a precise measurement of scattering on Si atomic shell electrons in a skipper CCD with single-electron resolution. Notable differences are observed between data and theoretical expectations in the L-shell energy region (<150 eV). We also present preliminary data from a skipper CCD exposed to low-energy neutrons (<24 keV) from a ^{124}124Sb^99Be photoneutron source, demonstrating a measurement of the nuclear recoil ionization efficiency in Si down to few ionization charges.


This paper presents a quantitative information security model using measurable values to describe the security of information systems in supply chain management (SCM) systems, [1]. There are four main drivers in a SCM system: 1) suppliers, 2) manufacturers and inventories, 3) distributors and retailers, and 4) the customers [2]. The security of supply chain management concerns the security of various interactions among these drivers. Each driver requires a different security level relevant to the services it contributes to the overall SCM system. A transition matrix representing the semi-Markov chain model of each driver is developed. Then, a system-wide security for SCM is produced using the transition matrices of each driver to reach a steady state of SCM information security. The model includes nine different levels of attacks presenting several scenarios for an intruder. Comparison of the steadystate security for multi driver model with different levels of attacks is presented. An analysis of the results is then presented and discussed.


The philosophy teaching at the higher education system is analyzed in the given article. In particular, the principles of "dialogue" as a remedy to reduce a so-called "intellectual provincialism" are elaborated. The main principle of philosophy teaching is defined as developing the "ontology of individuality". It is pointed out that self-determination of a student in a context of universal spiritual experience would be defined as a sense of philosophy teaching.


Objective To explore the relationship between pregnancy-associated plasma protein-A(PAPP-A) and carotid plague in patients with type 2 diabetes mellitus(T2DM).MethodsSerum PAPP-A levels were measured by ELISA in 60 patients with T2DM,who were divided into group A(30 cases without carotid plague) and group B(30 cases with carotid plague).Tumor necrosis factor(TNF)-α,glycosylated hemoglobin 1c(HbA1c),high-sensitive C reactive protein(hsCRP) and some other metabolic variables were also determined.The results were compared to those in 28 healthy controls(group C).Results The serum PAPP-A level was significantly higher in groups of A and B than that in group C(P0.05),which was higher in group B than that in group A(P0.05).Serum PAPP-A level was positively correlated with TNF-α in group B(P0.05).Conclusion PAPP-A is positively related with chronic inflammation factors in T2DM patients with carotid plagues.Serum PAPP-A togather with TNF-α may play an important role in developing carotid plague in diabetic patients.


Certain visual stimuli — particularly high-frequency flashing lights, deep red colors, and repetitive visual patterns — can induce seizures in photosensitive individuals. In 1997, more than 500 children in Japan had seizures while watching the Pokemon cartoon program. Various filtering techniques have been used to reduce photosensitive seizures, but these techniques diminish image quality.

Parra and colleagues applied a new …


This research, based upon a sample of 60 children representative of the 5-14 age group, attempted to identify the stages, skills and strategies associated with problem solving. The findings and conclusions arrived at following fairly extensive testing and analysis may be of importance to a cross-section of teachers but especially those dealing with science both in primary and secondary schools. The conclusions, which included the creation of a five-stage model of solving a problem, with the skills or strategies to be emphasised at each stage, are relevant not only to children in the 5-14 age group but to pupils undertaking a specific science course from year 10 (age 14+) onwards.


After the national government moved the capital to Nanjing,Beijing was renamed Peiping,which had a profound impact on literati's perspective of Beijing.As a result,Literati of the Left-wing,Nanjing National Government-attached,Shanghai School,the liberalism(Beijing School),and the enlightened made different descriptions and evaluations of Beijing image based on their political stance or cultural psy School chology.On the whole,during 1927 ~ 1933 Chinese Literati showed both"profound"and "serious"impression of Beijing.


Medicinal plants are important elements of indigenous medicinal system that have persisted in developing countries. Compounds that are capable of interacting with the immune system to up regulate or down regulate specific aspects of the host can be classified as immunomodulators. This study aimed at determining the regulatory activity of ethanol extract of Moringa oleifera in leukemic wistar rats using Tumuor necrosis factor assay. Thirty adult wistar rats were divided into three groups each containing ten wistar rats. Intravenous injection of 0.2 mg/ml of benzene chromosolv was administered 48 hourly for four weeks. 0.2 ml of 100 mg/ml of ethanol extract of Moringa oleifera was administered orally pre, during and post leukemia induction. Group A (Normal rats), Group B (benzene administration only) and Group C (benzene + ethanol Moringa oleifera extract). After a total period of eight weeks, the plasma samples of each of the groups was collected and analyzed using TNF-α kit by ELISA technique. The result showed that there was no significant difference in TNF-α levels between all the groups. However there was a mean ± standard deviation difference between the groups; the group of rats induced with leukemia without treatment (leukemia control) with 229.38 ± 58.17 ng/L, those treated with EMO after induction of leukemia had a mean and standard deviation of 219.38 ± 18.52 ng/L while the normal control group 209.04 ± 17.51 ng/L. This study concluded that the anti-cancer properties of Ethanol extract of Moringa oleifera results in the down regulation of TNF-α as treatment of cancer occurs. Also TNF-α level may be indicative of the clinical efficacy of therapy.


AIM
To determine the value of high-resolution MRI in pleural and chest wall diseases, the normal and pathologic costal pleura and adjacent chest wall between paravertebral and the axillary region were examined with contrast enhanced high-resolution T1-weighted MRI images using a surface coil.

MATERIAL AND METHODS
Normal anatomy was evaluated in 5 healthy volunteers and a normal specimen of the thoracic wall, and correlation was made with corresponding HR-CT and histologic sections. CT-proved focal and diffuse changes of the pleura and the chest wall in 36 patients underwent HR-MRI, and visual comparison of MRI and CT was done retrospectively.

RESULTS
Especially sagittal T1-weighted HR-MRI images allowed accurate delineation of the peripleural fat layer (PFL) and the innermost intercostal muscle (IIM), which served as landmarks of the intact inner chest wall. PFL and IIM were well delineated in 3/4 patients with tuberculous pleuritis, and in all 7 patients with non-specific pleuritis, as opposed to impairment of the PFL and/or the IIM, which was detected in 15/18 malignancies as a pattern of malignant chest wall involvement. In one case of tuberculous pleural empyema with edema of the inner chest wall HR-MRI produced false positive diagnosis of malignant disease.

CONCLUSION
HR-MRI images improved non-invasive evaluation of pleural and chest wall diseases, and allowed for differentiation of benign and malignant changes.


This paper proposes a target association algorithm with fuzzy inference on satellite electronic information, aiming at the association difficulties caused by the following problems: false alarms may exist in the observation, radar emitters can change radiating parameters and there are multiple platforms equipped with the same type of radar emitters in the observational scenario. Firstly, the electronic information is classified using the electromagnetic attributes and false targets are picked out to some extent by enforcing the spatiotemporal constraints. Secondly, according to the database of radar emitters, the classification results are recognized based on the radial basis function (RBF) neural network. Moreover, based on the similarity of the recognition results for different satellite electronic information, the initial association measurement can be constructed. Finally, to improve the association accuracy, an association modifying factor will be derived with fuzzy inference based on different kinds of appropriate auxiliary information. Experimental results on two groups of simulated data show its effectiveness and practicability.


To understand world politics, one must appreciate the context in which international systems develop and operate. Pedagogy studies demonstrate that the more active students are in their learning, the more they learn. As such, using computer simulations can complement and enhance classroom instruction. CIVILIZATION is a computer simulation game that allows players to build a civilization, competing against other civilizations. As players manage resources to develop their civilizations, establish diplomatic relations with other civilizations, strengthen trade relations, and engage in military and peace alliances, they become immersed in a simulated international system. This article explores the value of using CIVILIZATION as an active learning approach to teach international relations, focusing on the many ways in which students can better understand and appreciate the defining concepts, as well as the complexities, of international politics through playing a computer game.


The distribution of resources is uneven over space and time,which always leads to heterogeneous patches.Clonal plants usually occupy wider habitats because of powerful clonal growth and the physical connection between ramets promotes the adaptation to heterogeneous habitats. Clonal ramets can improve resource capture capacity in nutrientrich patches by the functional specializing of resource acquisition organs,then share these resources with the ramets in low nutrient patches through clonal integration,this pattern is called 'division of labor'. Our study selected Alternanthera philoxeroides,an invasive clonal weed,as the objective and studied on the morphological plasticity of roots in the heterogeneous patches of resources. Ramets were planted in the patches with heterogeneous distribution of light and soil nutrient and there were four treatments,e. g. 1two ramets experienced high light and low nutrient treatment( HL-HL);2two ramets experienced low light intensity and high nutrient treatment( LH-LH); 3proximal ramets experienced high light and low nutrient treatment,distal ramets experienced low light and high nutrient treatment( HL-LH); 4proximal ramets experienced low light and high nutrient treatment,distal ramets experienced high light low nutrient treatment( LH-HL). Parameters of roots were analyzed with WinRHIZO Pro software and the effect of treatment on these parameters of proximal ramets,distal ramets and whole ramet pairs was tested with one-way ANOVA( SPSS 18. 0). Our results were as follows: Ramets in high light and low nutrient patch allocated more biomass to aboveground parts,while ramets experienced low light and high nutrient allocated more biomass to the underground parts. A. philoxeroides ramets showed the division of labor by changing the root- shoot ratio of biomass. In heterogeneous environments,the root of A. philoxeroides ramets in the eutrophic patches had higher root biomass,root length,root surface area,root volume and branch coefficient,etc. A. philoxeroides increased nutrient uptake capacity through the form of root morphological plasticity in heterogeneity habitats. Thus,A. philoxeroides improved resource absorption capacity by specializing resource acquisition organs,which may play an important role in its successful invasion.


The 2nd book of the Catalan Civil Code regulates stepfamilies. The defining element of stepfamilies is that the spouses do not have children in common. While it is no longer legally relevant if the family is based on marriage, this question of children remains important. As a result of new legislation in Catalonia, the status of stepchildren has been strengthened. The legislature has provided that the third party may not only participate in decisions relating to everyday life but may also take the necessary measures when the child is in danger. In case of disagreement between the parent and the spouse or stable partner of the parent, the will of the parent prevails. If there is an imminent risk to the child, the spouse or stable partner of the parent who has custody of the child can take the necessary measures for the welfare of the child, and he must immediately inform his spouse or stable partner, who must inform the other biological parent. Exceptionally, in case of death of the custodial parent, the third party can have custodial child. If parent no custodial has custodial child, a formal relationship between the third party and the child may be established whenever he has lived with the child for the last two years. This last possibility represents the preservation of the relations against marital breakdown and offers important family cohesion, in particular if there are siblings. It shows that the regulation incorporates and reinforces the principle of the best interests of the child regarding stepfamilies.


The development of multiscale approaches for nanoscale simulations has become in recent years a research topic of practical interest. One objective for multiscale modeling is to combine different concurrent models in order to capture the different scales observed in complex problems. The underlying idea is to replace a reference particle model, supposedly intractable, by a coupled model that blends solutions from small and large scale models. In this work, a continuum (large scale) model is used far from the regions of interest and a particle (small scale) model is kept in the local critical regions; the two models are then coupled together based on the Arlequin framework [1, 2]. It is important to observe that such a multiscale model only constitutes a surrogate model of the initial particle model. Approximation errors arising from this surrogate model must therefore be estimated and controlled. We proposed in the past an adaptive method [3, 4] in which spatial contributions to the error in quantities of interest are used to adapt the position of the interface region between the two models. We present here a novel adaptive method based on optimal control in which the modeling errors are controlled with respect to some specific quantities of interest. We illustrate the performance of this new method on oneand two-dimensional problems and compare the efficiency of the two approaches.


This paper discusses issues concerning audit committee characteristics that lead to the occurrence of financial restatements in Malaysian public listed companies (PLCs). The audit committee characteristics were measured using size, independence, frequency of meetings, audit tenure, gender, expertise, age, ethnicity, legal qualifications, and political connections. The data in this study were extracted from the annual reports of 100 firms that had restated their financial statement between 2006 and 2015, and a total of 200 non-restatement firms were matched and observed as control firms. Using univariate and multivariate statistical analysis, the results evince that there is a significant association between audit committee size and frequency of meetings as well as ethnicity and political connections of the audit committee members and the occurrence of financial restatements in Malaysian PLCs. However, the remaining audit committee characteristics show insignificant association with the occurrence of financial restatements. Consistent with Wan Mohammad, Wasiuzzaman, and Nik Salleh (2016), the results show that larger and more rigorous audit committees can strengthen the monitoring role and consequently reduce the occurrence of financial restatements. In addition, the results evince that Malay members in the audit committee have widespread political connections, which negatively affect the decisions by the audit committee, thereby increasing the occurrence of financial restatements.


Abslru-This paper is primarily concerned with the utilization of fiber Bragg gratings (FBCa) and chirped longperiod gratings (CLPGs) ta realize a move1 wawleagth-tunable optical addldrop multiplexer (OADM) device. We considered the theory af fiber mragg gratings and bng-pericd gratings to explain the oprstiin of the new device. The method of strain used for tuning of the Rber Brags grating, channel isolslion, and ~roiit~lE beween ehsnnell are dro direussod. Indw Terms-Wavelength-tunnble, Addldrop mulliplerer, Chirped long-period gratings. Fiber Bragg gratings.


Abstract I begin this article by briefly explaining why I think CercleS should encourage university language centres to align their courses and assessment with the proficiency levels of the Common European Framework of Reference for Languages (CEFR) and why they should use a version of the European Language Portfolio (ELP) to support the development of students' skills of self-management and reflective learning. I then summarize the CEFR's action-oriented approach to the description of language proficiency and consider the implications of this approach for language teaching and learning. After that I explain how the ELP is meant to mediate the CEFR's ethos and approach to learners and draw attention to some of the factors that shape its effective use. I conclude by proposing three tasks that could usefully be undertaken by the CercleS CEFR/ELP Focus Group.


The tumor necrosis factor (TNF) superfamily consists of a wide variety of cell‐bound and secreted proteins that regulate numerous cellular processes. In particular, TNF‐family proteins regulate the proliferation and death of tumor cells, as well as activated immune cells. This overview discusses the mammalian TNF receptor‐associated factors (TRAFs), of which TRAF1, 2, 3, 5, and 6 have been shown to interact directly or indirectly with members of the TNF receptor superfamily. Structural features of TRAF proteins are described along with a discussion of TRAF‐interacting proteins and the signaling pathways activated by the TRAF proteins. Finally, we examine the phenotypes observed in TRAF‐knockout mice. Curr. Protoc. Immunol. 87:11.9D.1‐11.9D.19. © 2009 by John Wiley & Sons, Inc.


Lattice-doped UO2 pellets have been used as the simulated fuels to investigate the physical and chemical properties of spent nuclear fuel [1-5]. Because of spent nuclear fuel is consisted of mainly UO2 (95%) and minor elements such as radioactive fission products and actinides, lattice-doped UO2 is good model system to confirm influence of those minor elements on physicochemical behavior of UO2. For example, Gddoped UO2 was prepared and investigated to study the influences of trivalent rare earth on structure and corrosion of UO2 [3,4]. Its physical and chemical properties could be useful information to make strategies for long-term management of spent nuclear fuel including deep geological disposal. In this study, Ce-doped UO2 have been investigated the effect of Ce-doping on the UO2 structure and its electrochemical behavior.


Non-invasive blood glucose determination has been investigated by more than 100 research groups all over the world during the past fifteen years. Many measurement methods are based on the capacity of near-infrared light to penetrate a few millimetres into human tissue where it interacts with glucose. A change of glucose concentration may change the optical parameters in tissue, with the result that its glucose concentration can be extracted by analysing the received optical (or other) signals. This paper applies a streak camera in conjunction with the photoacoustic (PA) technique to study glucose determination on the based on optical scattering effect and on skin properties.


The European Union ROADEX Project 1998 - 2007 is a trans-national roads cooperation aimed at developing ways for interactive and innovative management of low traffic volume roads throughout the Northern Europe. Its goals have been to facilitate research into the common problems in the area. A major problem, shared by all the partners, has been poorly performing drainage. The problem has received general acknowledgement, but data which demonstrates the economic effect of drainage on pavement lifetime has yet to be produced. In this work, which was done as a part of the ROADEX III project, the condition of the drainage of the paved roads of the entire Rovaniemi maintenance area road network was classified. This network in Finnish Lapland presents a road network typical of the Northern part of Europe. The goals for this study were to assess the status of the current drainage condition, compare rutting and roughness values with the drainage condition and, based on these results, calculate the effect of poor drainage on pavement lifetime and annual paving costs. The results of this survey showed that rut development on main roads was 1.52 times faster in sections with the poorest, class 3, drainage than in sections with good quality, class 1, drainage. On local roads with thinner pavement structures the same pavement lifetime ratio was 2.32. Poor drainage had a similar effect on the roughness (IRI) values. The cost benefit calculations showed that, by improving the drainage of paved road networks to a class 1 level, it would be possible to save almost 12 % of the annual paving costs. In terms of the Rovaniemi maintenance area, a network that includes 645 km of paved roads, a savings of approximately 335.000 Euro could be achieved. The results of this analysis demonstrate the economic benefits of investments in improving drainage and maintaining it in good condition. For the covering abstract see ITRD E144473.


Part I: multiple classifier systems, J. Kittler building decision trees from the Fourier spectrum of a tree ensemble, H. Kargupta clustering large data sets, M.N. Murty multi-objective variable string genetic classifier - application to remote sensing imagery, S. Bandyopadhyay et al. Part II: dissimilarity measures between fuzzy sets or fuzzy structures, K.R. Bhutani and A. Rosenfeld early vision -concepts and algorithms, V.D. Gesu self-organizing neural network for multi-level image segmentation, A. Ghosh and A. Sen geometric transformation by moment method with wavelet matrix, Y.Y. Tang et al new computationally efficient algorithms for video coding, T. Acharya and H.M. Kim soft computing for computational media aesthetics - analyzing video content for meaning, S. Chaudhury et al. Part III: towards granular multi-agent systems, A. Skowron granular computing and pattern recognition, W. Pedrycz case base maintenance - a soft computing perspective, S.C.K. Shiu. Part IV: autoassociative neural network models for pattern recognition tasks in speech and image, B. Yegnanarayana et al protein structure prediction using soft computing, S. Mitra et al pattern classification for biological data mining, S.B. Cho.


This test report introduces the measurement of geometric and physical parameter and aerodynamic property of man and woman javelin for home and abroad. The measurement results indicate that the overall long, mass, center of gravity, center of area between the same kinds of javelins show little difference, usually within 1%. But the rotation moment of inertia are quite different. The aerodynamic drag and lift of javelin increase with angle of attack. The maximum lift-drag ratio about 2 nearby 20°. When center of gravity of javelin is moved forward, the center of pressure of javelin is always located after its center of gravity. Therefore, a great change of the aerodynamic property of javelin has taken place.


A numerical study of transient natural convection in a square cavity with partly thermally active side walls is introduced. The thermally active regions of the side walls are periodic in time. Top and bottom of the cavity are adiabatic. Nine different positions of the thermally active zones are considered. The governing equations are solved using control volume method with power-law scheme. The results are obtained for various values of amplitude, period, and Grashof numbers ranging from 104–106 and different thermally active situations. It is found that the average heat transfer increases by increasing amplitude for P=1,5, and decreasing for P=3. The average Nusselt number behaves nonlinearly as a function of period.


The article presents a research based on a sociological inquiry through a questionnaire regarding the views of the persons involved - priests, social workers and volunteers - in the socio-philanthropic activity of the Romanian Orthodox Church as a faith-based organization, on the social and spiritual dimensions of their own social-philanthropic and social assistance practice, and on the perceived impact of their professionalisation on the specificity and quality of the services provided. The research was carried out between September 2018 and February 2019 in the Archdiocese of Iasi, which consists of 13 deaneries and 1221 parishes, disposed on the territory of Iasi, Neamţ and Botosani Counties. The most important results of this research show that the social-philanthropic activity of the Orthodox Church is correlated with the liturgical one, the spiritual dimension being added to the assistential one, while the philanthropic and assistential activities are seen by the professionals as a continuum of the active practice of Orthodoxy in the form of Christian social assistance, which can make us conclude that the assistential organizations within the Orthodox Church in Romania may be, in general, with the exception of certain peculiarities, framed within the faith-permeated organizations typology.


Abstract Steganography is the concept of embedding or hiding secret information into a cover image by maintaining the visual quality. Various algorithms are designed to classify stego images but the race still continues between Steganographer and Steganalyser. Advances in deep learning provided a solution to detect stego images. In this article, we coin a new paradigm to detect stego image as a three-step process with the following repercussions: (1) employing preprocessing step to enhance the input image, (2 feature extraction using the Mustard honey bee optimization algorithm and, thus, the extracted features will be dimensionally reduced (3) by classification using HSVGG-based CNN. Experimentation carried out on ALASKA2 data set and the results were compared.


SPECULATIVE INTRODUCTION Once upon a time, when even the war was cold, we used to speak of "Eastern Europe." For a while, however, in the mid-1980s, some of us began to speak of Central Europe. Now we speak of East Central Europe, usually placing a hyphen between East and Central. What lies behind this shifting nomenclature? Does it show that despite legitimate postmodern-or merely commonsensical-- scepticism regarding history's fabled pursuit of an Heglian dialectic of opposites and final synthesization, some such dialectic does indeed unfold in what was once described as the superstructural realm, that of terminology and ideology, with each generation self-consciously seeking to trump predecessors by ostentatiously redressing their mistakes and appropriating their achievements, adding "Central" to "East" to yield the synthetic "East Central"? (Meanwhile, the gap or hyphen that separates "East" and "Central" recognizes the synthesis as threatened, incomplete, as the two terms become potentially non-synonymous or even-as it were-"opposed synonyms.") The general acceptance of the term "East Central," whatever else it may be, is of course the posthumous triumph of the historian Oskar Halecki, who first argued that Europe comprised a West Central Europe, which was Germanic, and a largely Slavic East Central Europe. "East Central" may be less a synthesis than a compromise between the way "the West" (another labile signifier) traditionally saw the countries in question (those of the former Warsaw Pact) as "Eastern" and the way those countries' denizens defined themselves-at least during the 1980s, the period of their greatest unrest and hope for change-as "Central." Their countries' forty-year sojourn within the belly of the Soviet whale nursed a chronic fear that "Eastern Europe" might indeed become the "Western Asia" it was termed sardonically by Joseph Brodsky, and as it might have been described by neo-Marxists noting the paradoxical persistence within the Revolution's vanguard country and what Marx had defined as "the Asiatic mode of production." "Central Europe" may have been a term steeped in utopianism (Mariola Jankun-Dopartowa, for instance, has described it as such2), a sign of wishful thinking, or a banner strategically unfurled in the mid- I 980s to persuade Western politicians that the realm they had consigned to a comfortable distance was nearer than they thought, and indeed central to the project of constructing a "European" identity-by no means amenable to sweeping under the red carpet in the name of d&ente. The recent general adoption of "East Central" instead may in turn represent an Eastern assertion of difference from a "Central Europe" that translates into the uncomfortably Germanic Mitteleuropa. The insistence on the new term may seek magically to banish fears of economic ingestion by a Germany whose first tottering Eastward steps to absorb its own East might generate unstoppable momentum towards the malign old programme of the Drang nach Osten, in whose throat Eastern Europe would prefer to stick. The term is perturbingly unstable, and the compromise is not-pace Fukuyama-the end of history but a moment of balance within it, perhaps precarious but hopefully long. But will "East Central" be treated as "East" again-no real concern of ours-should a humiliated Russia seek to claw back its lost empire, in part or in full? What meanings and perhaps repressions and reservations underlie this phrase and its relation to previous names for this geo-political space? The designation appears to indicate an area that has overcome its past-in 1989, for instance-and yet somehow preserves it (the Hegelian dialectic summed up in the term Aujhebung, in which what is surpassed is also "stored up"). It functions both as a name and a confession of failure to name, the sign of a perception of the area as resistant to naming, transitional, suspended, perhaps permanently indeterminate, and thus a source of difficulty-future as well as past? …


The population of present study included 165 families residing in a randomly selected semi urban area in Ernakulam district, Kerala, India. The investigator has implemented a strategy of Behavioral change interventions to control aedes aegypti mosquitoes through source reduction which consisted of a Propaganda, Household personal and family counseling and a Mass health education programme. The post test results showed that there is significant reduction in the aedes aegypti mosquito indices of the area.


ulfated glycans play critical roles during the development, differentiation and growth of various organisms. The most well‐studied sulfated molecules are sulfated glycosaminoglycans (GAGs). Sulfation at any particular site on a certain glycan is usually unsaturated in vivo. Therefore it is possible to introduce radioisotope 35S to specific glycans using recombinant sulfotransferases in vitro, thereby allowing detection of minute quantities of particular glycans. As examples, we tested contaminant GAGs in commercial heparin, heparan sulfate and chondroitin samples. The identities of the contaminating GAGs were further confirmed by digestion using GAG‐specific lyases. This strategy can also be used to detect oversulfated chondroitin sulfate following a simple desulfation step. In addition, in vitro sulfation by sulfotransferases allowed us to map glycan epitopes in biological samples. This was illustrated using mouse embryo and rat organ tissue sections labeled with sulfotransferases of CHST3, CHST15, HS3ST1, CHST4 and CHST10.


Population status, habitat use and threats to conservation of Alpine musk deer (AMD; Moschus chrysogaster) were studied at 13 sites between 2500 and 4500 m a.s.l. in Uttarakhand Himalayas (India) from October 2003 to December 2006. Forest trails were monitored to estimate the abundance of AMD. Data on current status and habitat use of AMD and associated ungulate species were collected by sampling of pellet groups. The relative abundance of AMD in terms of encounter rate (groups/km) and pellet groups density (pellet groups/ha) was highest in Saukherk (1.3 groups/km and 58.8 ± 8.9 pellet groups/ha, respectively). AMD pellet group numbers-habitat assessment matrix was subjected to principal component analysis to determine ecological gradients governing spatial occurrence of AMD. The first two principal components accounted for 23.7% of variation and these were related to shrub-layer attributes and livestock dung abundance, grazing and grass density, respectively. The discriminant function analysis was performed to determine spatial ecological separation between AMD and other sympatric ungulate species. Altitude, shrub density, distance to human habitation and herb density were key factors which separate musk deer from other species. Poaching of AMD for musk gland emerged as principal threat to species across sites. Elimination of poaching, strengthening the management of existing protected areas (PA) and involvement of local communities are recommended for long-term conservation of AMD.


A survey of Saskatchewan cooperatives undertaken by the centre in 1986 and reported in this volume should alert us to some variations which need to be understood in historical terms. As opposed to wheat pools and credit unions, housing and child care cooperatives are largely the product of new urban social movements which emerged over the past twenty-five years. Their proponents reflect less the ideals of Rochdale or of prairie populism than of feminism and urban community organizing. What do such developments portend for the future of cooperative development? There are corollaries to this observation which could add substance, for instance, to the otherwise generally insightful analysis of the relationship of cooperatives to the state. If the state opts to deliver some social services through funding such cooperafives, a whole new set of issues about membership control is raised. More generally, the lack of a historical framework leaves the contributors ill equipped to address the real dilemmas that will face Canadian cooperatives over the next few years. How will co-ops confront deep structural transformations in the global economy? How will the Free Trade Agreement and GAIT negotiations on agriculture affect the wheat pools? Will cooperafives have a role to play in a new international division of labour? If, as the authors argue, cooperatives arose in the context of structural change as a means of preserving communities and supplementing a market system which fails to provide spedtic needs, then it would seem that cooperatives have, potentially, a new agenda. Whereas marketing mechanisms and consumer goods were often lacking in the past, late capitalism seems to be decreasingly capable of providing meaningful and remunerative mployment. What is the prognosis for employee buy-outs of failing industries and the establishment of worker cooperatives? Is this a direction for the future? Does it provide any real respite? These are some of the 'dilemmas of change' confronting Canadians and cooperatives which are not discussed in this volume. Cooperafives, and those who study them, will need even more imagination if they hope to weather the storm. jAMES N^3⁄4LOV• University of Winnipeg


Cr12Mo V cold worked die steel was boronized with hot dip method,which was strengthened with laser quenching( LQ),the surface and interface morphology,composition of chemical elements and phases of the layer were characterized by SEM,EDS and XRD,respectively. The results show that the gaps of boronized layer after LQ decrease to reduce the flaking chance. The new phase of Fe2 B and Fe-Cr compound are produced after LQ in the boronized layer,but mainly composed of Fe B,which decreased brittleness of boronized layer. The element diffusion is not obvious and rich carbon zone is still existed,and its toughness and strength get improved by a finer microstructure. Si atom of the gaps can dissolve into austenite with uniform distribution after LQ,and the combining of Cr and Fe enhances bonding strength of boronized layer.


Introduction
 Activating mutations in RAS have been reported in about 10-15% of patients with AML. Previous studies have not identified a prognostic significance for RAS mutations in AML treated with conventional chemotherapy. However, RAS mutations have emerged as a potential mechanism of resistance to treatment with small molecule inhibitors of FLT3, IDH, and BCL2. With broader availability of next generation sequencing, and the identification of wider heterogeneity in AML, we aimed to better characterize the genomic landscape of RAS mutated AML and outcomes within various subsets.
 Methods
 We conducted a retrospective analysis in 1410 consecutive patients with newly diagnosed (ND) AML) treated at out institution from 12/2011 to 01/2020, who had a baseline genomic testing available. Patients were treated with a variety of therapies, classified as: HMA-alone, HMA+Venetoclax (Ven), Intensive chemotherapy (HiDAC based), Intensive+Ven, low intensity double nucleoside analogue (cladribine+LDAC; Clad/LDAC), and Clad/LDAC + Ven. Response rates and outcomes were analyzed by age, cytogenetic prognostic subgroup (favorable [FAV], diploid [DIP], other intermediate [INT], adverse [ADV]), and type of therapy in the context of mutated (RAS-mut) or wild type RAS (RAS-WT). We sought to characterize the impact of RAS mutations on AML outcomes in the era of targeted therapy.
 Results
 Baseline patient and disease characteristics are detailed in table 1. Among 1410 patients with ND AML, 273 (20%) were RAS-mut; of these, 196 (72%) had NRAS-mut, 47(17%) had KRAS-mut, and 29(11%) had both. Patients with RAS-mut were younger(median age 62 vs. 66 years; P=0.001) and had higher a median WBC (P=0.02) and platelet count (P=0.01) at diagnosis compared to those with RAS-WT. Among the cytogenetic groups: FAV, INT, DIPLOID, ADV, RAS-mut were present in 39%, 20%, 16%, and 6%, respectively. Patients with RAS-mut were more likely to have concomitant mutations in ASXL1 (13%; P=0.03), , RUNX1 (10%; P=0.03), and less likely to have concomitant mutations in JAK2 (1%; P=0.03) and TP53 (8%; P<0.01). Outcomes by subset and by therapy group are summarized in Table 2. Although there was a trend in favor of RAS-mut, there was no significant difference in OS among pts younger or older than 60 yrs of age by RAS mutation. There was no difference in OS by NRAS or KRAS mutation (median OS 16 vs. 16.5 m; P=0.45). Pts with RAS-mut AML classified as non-secondary/de novo AML (P=0.003), therapy-related AML (P=0.02), and those who received intensive therapy had a significantly better OS compared to RAS-WT. The addition of Ven to each therapy group was associated with higher response rates and median OS but were not statistically significant (Figure 1). Response rates among patients with or without RAS mutations were similar, with a trend for better responses with araC-based therapy, compared to non-araC based. Compared to RAS-WT, RAS-mut was associated higher response among pts with diploid karyotype, de novo AML, and those treated with intensive therapy. Among pts with MLL-rearrangements (P=0.09) and MECOM translocation (P=0.06), RAS-mut was associated with lower response rates compared to RAS-WT. Among patients with TP53 mutated AML, co-mutation with RAS was associated with worse outcomes compared to RAS-WT (CR rates of 4% vs. 16% P<0.001; median OS 3.4 vs. 5.8 months, P=0.77).
 Conclusion
 RAS mutations are present across AML subsets, with higher representation among pts with FAV cytogenetics and relative underrepresentation among pts with ADV karyotype and TP53-mutations. Among patients with DIP cytogenetics, de novo AML, and those treated with intensive therapy, RAS-mut are associated with higher response rates and more favorable outcomes. Early observations suggest modest improvements in ORR with the addition of Ven to chemotherapy but no OS benefit. Targeting the RAS pathway among specific AML subsets remains an important area of further research.
 Figure 1

 Kantarjian: Daiichi-Sankyo: Research Funding; AbbVie: Honoraria, Research Funding; Immunogen: Research Funding; BMS: Research Funding; Jazz Pharma: Research Funding; Novartis: Research Funding; Ariad: Research Funding; Amgen: Honoraria, Research Funding; Actinium: Honoraria, Membership on an entity's Board of Directors or advisory committees; Agios: Honoraria, Research Funding; Cyclacel: Research Funding; Pfizer: Honoraria, Research Funding; Astex: Research Funding; Takeda: Honoraria. Borthakur:Curio Science LLC: Consultancy; Oncoceutics: Research Funding; Xbiotech USA: Research Funding; Polaris: Research Funding; AstraZeneca: Research Funding; BMS: Research Funding; BioLine Rx: Research Funding; Cyclacel: Research Funding; GSK: Research Funding; Jannsen: Research Funding; Abbvie: Research Funding; Novartis: Research Funding; Incyte: Research Funding; PTC Therapeutics: Research Funding; FTC Therapeutics: Consultancy; BioLine Rx: Consultancy; PTC Therapeutics: Consultancy; Argenx: Consultancy; BioTherix: Consultancy; Nkarta Therapeutics: Consultancy; Treadwell Therapeutics: Consultancy. Konopleva:AbbVie: Consultancy, Research Funding; Sanofi: Research Funding; Kisoji: Consultancy; Genentech: Consultancy, Research Funding; Cellectis: Research Funding; F. Hoffmann La-Roche: Consultancy, Research Funding; Reata Pharmaceutical Inc.;: Patents & Royalties: patents and royalties with patent US 7,795,305 B2 on CDDO-compounds and combination therapies, licensed to Reata Pharmaceutical; Rafael Pharmaceutical: Research Funding; Amgen: Consultancy; Eli Lilly: Research Funding; Forty-Seven: Consultancy, Research Funding; Stemline Therapeutics: Consultancy, Research Funding; Agios: Research Funding; Ascentage: Research Funding; Ablynx: Research Funding; AstraZeneca: Research Funding; Calithera: Research Funding. Pemmaraju:Samus Therapeutics: Research Funding; Blueprint Medicines: Honoraria; Daiichi Sankyo: Research Funding; Affymetrix: Other: Grant Support, Research Funding; MustangBio: Honoraria; Celgene: Honoraria; Cellectis: Research Funding; Pacylex Pharmaceuticals: Consultancy; AbbVie: Honoraria, Research Funding; Incyte Corporation: Honoraria; Plexxikon: Research Funding; Novartis: Honoraria, Research Funding; Roche Diagnostics: Honoraria; SagerStrong Foundation: Other: Grant Support; DAVA Oncology: Honoraria; Stemline Therapeutics: Honoraria, Research Funding; LFB Biotechnologies: Honoraria. Daver:Daiichi Sankyo: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Karyopharm: Research Funding; Servier: Research Funding; Genentech: Research Funding; AbbVie: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Novimmune: Research Funding; Gilead: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Trovagene: Research Funding; Fate Therapeutics: Research Funding; ImmunoGen: Research Funding; Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Celgene: Consultancy, Membership on an entity's Board of Directors or advisory committees; Jazz: Consultancy, Membership on an entity's Board of Directors or advisory committees; Trillium: Consultancy, Membership on an entity's Board of Directors or advisory committees; Syndax: Consultancy, Membership on an entity's Board of Directors or advisory committees; Amgen: Consultancy, Membership on an entity's Board of Directors or advisory committees; KITE: Consultancy, Membership on an entity's Board of Directors or advisory committees; Agios: Consultancy, Membership on an entity's Board of Directors or advisory committees. DiNardo:Novartis: Consultancy; Notable Labs: Membership on an entity's Board of Directors or advisory committees; Syros: Honoraria; Jazz: Honoraria; Celgene: Consultancy, Honoraria, Research Funding; MedImmune: Honoraria; Calithera: Research Funding; ImmuneOnc: Honoraria; AbbVie: Consultancy, Honoraria, Research Funding; Agios: Consultancy, Honoraria, Research Funding; Daiichi Sankyo: Consultancy, Honoraria, Research Funding; Takeda: Honoraria. Jabbour:Pfizer: Other: Advisory role, Research Funding; Adaptive Biotechnologies: Other: Advisory role, Research Funding; Takeda: Other: Advisory role, Research Funding; Genentech: Other: Advisory role, Research Funding; BMS: Other: Advisory role, Research Funding; AbbVie: Other: Advisory role, Research Funding; Amgen: Other: Advisory role, Research Funding. Yilmaz:Pint Pharma: Honoraria; Pfizer: Research Funding; Daicho Sankyo: Research Funding. Andreeff:Daiichi-Sankyo; Jazz Pharmaceuticals; Celgene; Amgen; AstraZeneca; 6 Dimensions Capital: Consultancy; Amgen: Research Funding; Daiichi-Sankyo; Breast Cancer Research Foundation; CPRIT; NIH/NCI; Amgen; AstraZeneca: Research Funding; Centre for Drug Research & Development; Cancer UK; NCI-CTEP; German Research Council; Leukemia Lymphoma Foundation (LLS); NCI-RDCRN (Rare Disease Clin Network); CLL Founcdation; BioLineRx; SentiBio; Aptose Biosciences, Inc: Membership on an entity's Board of Directors or advisory committees. Garcia-Manero:H3 Biomedicine: Research Funding; AbbVie: Honoraria, Research Funding; Genentech: Consultancy, Membership on an entity's Board of Directors or advisory committees, Research Funding; Amphivena Therapeutics: Research Funding; Onconova: Research Funding; Bristol-Myers Squibb: Consultancy, Research Funding; Celgene: Consultancy, Honoraria, Research Funding; Helsinn Therapeutics: Consultancy, Honoraria, Research Funding


The invention discloses a lifting method suitable for being used in a narrow space. The method comprises the following steps: (1) erecting a holding pole in the narrow space, respectively fixing the upper and lower ends of the holding pole on structures in a lifting space, arranging a lifting cantilever crane which is rotationally connected with the holding pole on one side of the holding pole, and obliquely arranging the lifting cantilever crane; and (2) mounting hoisting equipment on the top of the lifting cantilever crane, lifting a heavy object by adopting the hoisting equipment, and conveying the heavy object along an annular route by adopting the lifting cantilever crane. The safety and the reliability of the lifting operation can be guaranteed, the annular transport of the heavy object can be conveniently realized, the annular lifting and the in-place transport of the heavy object in the narrow space are realized, the requirements on the transport ground and the transport space are low, and the applicability is high. Moreover, the equipment is simple in structure and easy to manufacture, the investment of mechanical equipment and manual labor is low during manufacturing, and materials used in the manufacturing are high in secondary recovery rate and low in cost.