We present and compare several models for automatic identification of instrument classes in polyphonic and poly-instrument audio. The goal is to be able to identify which categories of instrument (Strings, Woodwind, Guitar, Piano, etc.) are present in a given audio example. We use a machine learning approach to solve this task. We constructed a system to generate a large database of musically relevant poly-instrument audio. Our database is generated from hundreds of instruments classified in 7 categories. Musical audio examples are generated by mixing multi-track MIDI files with thousands of instrument combinations. We compare three different classifiers : a Support Vector Machine (SVM), a Multilayer Perceptron (MLP) and a Deep Belief Network (DBN). We show that the DBN tends to outperform both the SVM and the MLP in most cases.


The expert system for time series analysis of irregularly spaced signals is reviewed. It consists of a number of complementary algorithms and programs, which may be effective for different types of variability. Obviously, for a pure sine signal, all the methods should produce the same results. However, for irregularly spaced signals with a complicated structure, e.g. a sum of different components, different methods may produce significantly different results.
The basic approach is based on classical method of the least squares (1994OAP.....7...49A). However, contrary to common "step-by-step" methods of removal important components (e.g. mean, trend ("detrending"), sine wave ("prewhitening"), where covariations between different components are ignored, i.e. erroneously assumed to be zero, we use complete mathematical models.
Some of the methods are illustrated on the observations of the semi-regular pulsating variable RY UMa. The star shows a drastic cyclic change of semi-amplitude of pulsations between 0.01 to 0.37mag, which is interpreted as a bias between the waves with close periods and a beat period of 4000d (11yr). The dominating period has changed from 307.35(8)d before 1993 to 285.26(6)d after 1993. The initial epoch of the maximum brightness for the recent interval is 2454008.8(5). It is suggested that the apparent period switch is due to variability of amplitudes of these two waves and an occasional swap of the dominating wave.


Famous Paintings in the History is an important work in the Chinese painting history. The author aimed to provide overall guidance for the "painting collector" to collect ancient paintings,the purpose was not only determine the its rich content and perfect system,butalsodecided thatitisnota generalhistorybook,buta theoryforlearning and collection.


Abstract : This project had two main components: the a) initiation and b) propagation aspects of coronal mass ejections (CMEs) from the Sun that are directed towards the Earth. In the context of stellar coronal field dynamics leading to CME initiation, the major outcomes from this project are that i) only the total amount of magnetic flux content in solar active regions and not their non-potentiality (or current content) governs coronal X-ray emission, ii) Kink-instability does seem to play an important role in the initiation of solar storms. With regard to the propagation aspects, the work done in this project has resulted in three specific outcomes -- i) an explicit demonstration of the fact that the Lorentz self-force acting on CMEs arises from misaligned currents and magnetic fields, ii) a recognition that solar wind drag on slow CMEs might only be effective for heliocentric distances greater than 60 to 80 solar radii, and iii) a clear elucidation of the role cross-field diffusion plays in mediating the interaction between galactic cosmic rays and magnetic field compressions caused by CMEs and their associated shocks near the Earth.


Several chromium-free pickling and activation processes were investigated in order to develop an eco-friendly pretreatment for electroless Ni-P plating on magnesium alloy. The coatings obtained from etching only in H3PO4 solution exhibit poor adhesion due to the existance of an interlayer. Meanwhile, a corrosion model of Mg alloy in H3PO4 solution was proposed. When fluoride was added into the pickling solution, the adhesion of the coatings was also unsatisfied because of the bad mechanical interlocking action. By comparison, the coatings obtained from pickling in H3PO4 solution followed by NH4HF2 activation displayed wonderful properties in both adhesion and corrosion resistance. © The Author(s) 2014. Published by ECS. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives 4.0 License (CC BY-NC-ND, http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reuse, distribution, and reproduction in any medium, provided the original work is not changed in any way and is properly cited. For permission for commercial reuse, please email: firstname.lastname@example.com. [DOI: 10.1149/2.0601503jes] All rights reserved.


Studies have been conducted in recent years to improve the cost attributes associated with photovoltaic power systems. At PV inverter level, this can be achieved by reducing the number of components used in the power conditioning stage. In line with this, various maximum power point tracking (MPPT) techniques without using current sensor have been proposed in the last decade. This paper presents an overview of some main current sensorless MPPT techniques available hitherto. The insight analysis and classification of the existing tracking strategies is important for further research in the area. The simulation results of the Flyback Inverter based PV power systems controlled by a current sensorless MPPT in MATLAB/SIMULINK are also presented to illustrate the estimation effectiveness.


Objective: The purpose of this study was to determine the relationship between center of pressure (CoP) and local stability of the lower joints, which was calculated based on approximate entropy (ApEn) during walking in elderly women. Method: Eighteen elderly women were recruited (age: 66.4±1.2 yrs; mass: 55.4±8.3 kg; height: 1.56±0.04 m) for this study. Before collecting data, reflective marker triads composed of 3 non-collinear spheres were attached to the lateral surface of the thigh and shank near the mid-segment to measure motion of the thigh and shank segments. To measure foot motion, reflective markers were placed on the shoe at the heel, head of the fifth metatarsal, and lateral malleolus, and were also placed on the right anterior-superior iliac spine, left anterior-superior iliac spine, and sacrum to observe pelvic motion. During treadmill walking, kinematic data were recorded using 6 infrared cameras (Oqus 300, Qualisys, Sweden) with a 100 Hz sampling frequency and kinetic data were collected from a treadmill (Instrumented Treadmill, Bertec, USA) for 20 strides. From kinematic data, 3D angles of the lower extremity's joint were calculated using Cardan technique and then ApEn were computed for their angles to evaluate local stability. Range of CoP was determined from the kinetic data. Pearson product-moment and Spearman rank correlation coefficient were applied to find relationship between CoP and ApEn. The level of significance was determined at p <.05. Results: There was a negative linear correlation between CoP and ApEn of hip joint adduction-abduction motion ( p <.05), but ApEn of other joint motion did not affect the CoP. Conclusion: It was conjectured that ApEn, local stability index, for adduction/abduction of the hip joint during walking could be useful as a fall predictor.


Cystoid macular oedema without leakage on intravenous fluorescein angiography is a rare condition that has been associated with taxane chemotherapy. We report a patient with paraneoplastic retinopathy associated with melanoma who developed this distinctive form of maculopathy after starting treatment with paclitaxel.


Computational chemistry is a branch of chemistry that uses principles of computer science to assist in solving chemical problems. It uses the results of theoretical chemistry, incorporated into efficient computer programs, to calculate the structures and properties of molecules and solids. The lignocellulosic materials are mainly made up of a complex network of three polymers: cellulose, hemicellulose, and lignin. Due to their hydrophilicity, biodegradability, biocompatibility and low toxicity, hemicelluloses have been studied by numerous research groups with respect to their use as composites in biomedical applications. In this research, rice husk and gluten husk were analyzed. Rice husk (RH) is a fibrous material, composed mainly of cellulose, lignin and inorganic and organic compounds. Rice husk ash (RHA) is a light material, which is bulky and porous; it amounts to about 20% of the burnt husk. Gluten is the composite of a gliadin and a glutenin, which is conjoined with starch in the endosperm of various grass-related grains. The prolamin and glutelin from wheat (gliadin, which is alcohol-soluble, and glutenin, which is only soluble in dilute acids or alkalis) constitute about 80% of the protein contained in wheat fruit. The analysis techniques used were: FTIR to study this effect and the optional use of theoretical calculationsto justify the obtained results by means of computational chemistry tools. Using QSAR properties, we can obtain an estimate of the activity of a chemical from its molecular structure only. The QSARs have been successfully applied to predict soil sorption coefficients of non-polar and nonionizable organic compounds, including many pesticides. Sorption of organic chemicals in soils or sediments is usually described by sorption coefficients. The molecular electrostatic potential (MESP) was calculated using the AMBER/AM1 method. These methods give information about the proper region by which compounds have intermolecular interactions between their units.


Objective — To determine whether isovolumic relaxation flow (IRF) and isovolumic contraction flow (ICF) resulted from asynchrony and asynergy due to VVI and DDD pacemakers modulated neurohormones, we measured neurohormone levels in plasma and investigated the characteristics of IRF and ICF using Doppler echocardiography. Methods and results — We studied 11 patients with dual-chamber pacemakers (DDD) and 11 patients, with ventricular inhibiting mode (VVI). All patients underwent Doppler echocardiography of the left ventricle. Atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), renin and aldosteron were measured.The LV was scanned for the presence of intracavitary flow during the isovolumic relaxation and isovolumic contraction period. The plasma levels of BNP and ANP were significantly lower in DDD mode than in VVI mode (56±32 pg/ml vs. 94±32 pg/ml, p = 0.022 and 98 ± 20 pg/ml vs. 134 ± 17 pg/ml, p = 0.042, respectively).There were no significant differences in the plasma level of renin or aldosteron. VVI mode versus DDD mode increased isovolumic relaxation flow time (129 ± 41 vs. 111 ± 36 sec, p = 0.020) and isovolumic relaxation flow velocity (50 ± 4 vs. 37 ± 2 cm/s, p = 0.018).∞ A strong relationship between blood ANP and BNP levels and IRF velocity was found in patients with a VVI pacemaker (r: 0.632, p: 0.028; r: 0.528, p: 0.024, respectively). Conclusion — VVI mode has a longer isovolumic relaxation time, isovolumic relaxation flow velocity and has higher ANP and BNP plasma levels than DDD mode. IRF resulting from asynergy and asynchrony in VVI mode pacemakers versus DDD mode pacemakers affects the plasma levels of ANP and BNP compared to renin and aldosteron.


The author reveals the development features of such important social phenomenon as physical culture and sport in district cities of Russia at the end of the XIXth the beginning of the XXth century by the example of Velikie Luki and pays special attention to physical education development in secondary schools, physical culture traditions in national culture, the amateur nature of sport development as well as military and sport training of population during the First World War.


Process for the reconfiguration of several logical Printer, when changing from one Monitoring program to a second Monitoring program of the monitored printer automatically reconfigured, wherein the monitoring program passes over a network the data transmitted to a logical printer print jobs to a connected physical printer, wherein at least one physical printer is able to be connected with each logical printer, the method comprising : determining a plurality of logical printers; determining whether each belongs to each of the plurality of logical printer associated physical printer of a particular class; the entry of each associated with a physical printer of the particular class logical printer in a data structure; and the reconfiguration of each printer from the plurality of registered in the data structure logical printer to use the second control program for the transfer of print jobs to a physical printer of the particular class.


The Next Generation Networks (NGN) aims to integrate for IP-based telecom infrastructures and provide most advance & high speed emerging value added services. NGN capable to provide higher innovative services, these services will able to integrate communication and Web service into a single platform. IP Multimedia Subsystem, a NGN leading technology, enables a variety of NGN-compliant communications services to interoperate while being accessed through different kinds of access networks, preferably broadband. IMS–NGN services essential by both consumer and corporate users are by now used to access services, even communications services through the web and web-based communities and social networks, It is key for success of IMS-based services to be provided with efficient web access, so users can benefit from those new services by using web-based applications and user interfaces, not only NGN-IMS User Equipments and SIP protocol. Many Service are under planning which provided only under convergence of IMS & Web 2.0. Convergence between Web 2.0 and NGN-IMS creates and serves new invented innovative, entertainment and information appealing as well as user centric services and applications. These services merge features from WWW and Communication worlds. On the one hand, interactivity, ubiquity, social orientation, user participation and content generation, etc. are relevant characteristics coming from Web 2.0 services. Parallel IMS enables services including multimedia telephony, media sharing (video-audio), instant messaging with presence and context, online directory, etc. all of them applicable to mobile, fixed or convergent telecom networks. With this paper, this paper brings out the benefits of adopting web 2.0 technologies for telecom services. As the services are today mainly driven by the user's needs, and proposed the concept of unique customizable service interface.


The paper describes problems in the landscape design for open space of residential community of modern cities in our country,advocates the design idea of new eclecticism to solve a series of problems,and introduces some main design points of the design,so as to create the active public open space.


Traditional protection gives only terminal condition on the basis of protection of transformer. Discrimination between an internal fault and a magnetizing inrush current has long been recognized as a challenge for power transformer protection. To characterize and discriminate the transient arising from magnetization and inter-turn faults are presented here. This characterization will give value added information for improving protection algorithm.. The detection method can provide information to predict fault ahead in time so as that necessary corrective actions are taken to prevent outages and reduce down time. The data is taken from different test results like normal (magnetization) and abnormal (inter-turn fault) in this work, Discrete Wavelet Transform concept is used. Feature extraction and method of discrimination between transformer magnetization and fault current is derived by Discrete Wavelet Transform (DWT) Tests are performed on 2KVA, 230/230Volt custom built single phase transformer. The results are found using Discrete and conclusion presented.


As demonstrated by examples from my family business, the techniques of anthropology have a significant role in retailing. The research methods of anthropology facilitate qualitative observations, formal or informal interviews, and dialogues. Accordingly, the "life story approach" can be particularly useful. Many of these techniques can be usefully applied by lay people with minimal formal training in the field. In this article, by using life story and autoethnographic approaches, I share several personal stories with the readers of how anthropology was used in the different businesses in which my family and I were involved. Those who share the same practical business experiences as I, may learn how daily business operations can be studied, developed and managed. As a business owner, I recognize the importance of anthropological methods which benefit the business community through practical application.


I will commence by briefly outlining the origins of the Northern Teritory's Oral History Program. The NT Government first began to fund a program of oral history interviews in 1979, which was not only in the same year as the formation of the OHAA, but was also in the year- after the commencement of the current period of self-government for the Territory. From its inception till the present the program has involved one full-time public servant and modest annual funds for a number of people to be employed part-time, either to record interviews or transcribe.


Party's construction is a systems engineering,the party spirit construction is this systems engineering software actuates the system,the party spirit harmony relates the country the long-term peace and good government,also relates the society the harmonious development,unifies our country current society reality,strengthened aspect and so on party's under new historical condition empathy with the people,sophistication,accountability and sense of mission construction research,strengthens the party the rallying point,the cohesive force,the leader strength,enhances the party ruling ability and the level,realizes our party powerful nation prosperous common peopleIdeal desire.


Combining the current experiment demand of relay protection courses,in this paper,a design method of comprehensive experimental platform for the line current protection was proposed.In this device,the first circuit could simulate the transmission and distribution lines impedance through the adjustable resistance and fault can be set.In secondary circuit,loop current relay protection is set to ensure the students to understand the basic theory of knowledge,and develop hardware platform for the comprehensive innovative,open experiments,and according to the experiment course content arrangement,the experimental effect is ensured.Practice proves that the device is practical.


In a sizeable proportion of children with ADHD, their difficulties persist into adulthood. When the symptoms of ADHD, such as poor attention span and impulsivity, persist into adult life, this is known as residual ADHD. When an adult has problems that arose as a result of his having had childhood ADHD, such as poor academic skills and low self-esteem, these are known as secondary problems. This chapter discusses ADHD in adulthood, including residual ADHD, secondary problems, characteristics of residual ADHD, and diagnosis and treatment of residual ADHD and secondary problems. It also covers transition from childhood services to adulthood services, including the barriers to transition and strategies to overcome them.


One important objective of economic policy in developing countries, which include the Republic of Tajikistan, is the choice of an acceptable model of economic growth. In this article states that the theory of economic growth, a new trend, that proposed the thesis that education is a major missing element in economic growth and human capital investment, provide high quality and measurable rate of return. In this regard, at a time when issues of economic growth and development acquired for the economies of newly independent countries of importance, the study of theoretical and applied issues of this topic deserves further exploration. Choosing an adequate model of economic growth can contribute to the choice of effective ways of developing production and raising the level of material welfare. On this basis "human capital" acquires particular importance in the effective economic growth both in terms of knowledge, the importance of education and improving levels of professionalism, and in terms of new trends in the structure of demand.


SUMO (Small Ubiquitin‐like MOdifier) conjugation is a post‐translational modification implicated in a variety of cellular functions including transcriptional regulation, nuclear location and signal transduction. Sumoylation, although conserved and vital in eukaryotes, has not been studied in malaria parasites. Here, we identify SUMO conjugation of blood stage parasites of Plasmodium falciparum. Antibodies raised against synthetic peptides of the plasmodial SUMO orthologue PfSUMO, a 100‐amino‐acid protein, reacted with distinctive subcellular compartments of the parasitized erythrocyte during blood stage development. Anti‐PfSUMO stains the nucleus and parasite cytoplasm. We also found antibody reactivity in the host cell cytoplasm with the parasite‐derived structures called Maurer's clefts. Anti‐PfSUMO reacts in Western blot with a number of blood stage proteins ranging from approximately 40–250 kDa. Parasites expressing FLAG‐tagged PfSUMO gave similar results in Immunofluorescence assay and Western blots. In addition, we show that anti‐PfSUMO identified PfSir2, a telomere‐associated nuclear protein involved in var gene silencing, as a target for sumoylation. Furthermore, LC‐MS/MS analysis of a two‐step immunoprecipitation (IP) with anti‐FLAG and anti‐PfSUMO antibodies reveals a number of putative P. falciparum sumoylated proteins. Our results imply that SUMO conjugation has an essential function in a number of different biological processes in P. falciparum.


Objective: Renal cell carcinoma (RCC) is a rare and difficult to treat cancer. The case series aimed to observe the effects of medicinal mushrooms and integrative oncology care for renal cell carcinoma.
Clinical Features: Patients diagnosed with RCC who were being treated with surgery and chemotherapy and were administered integrative treatment in the form of supplements and medicinal mushrooms and/or combinations of mushrooms.
Interventions and outcomes: Integrative care included a combination of supplements and the medicinal mushrooms Ganoderma lucidum, Trametes versicolor, Cordyceps sinensis, Grifola frondosa, and Lentinus edodes in combination or alone, which was initiated following adjuvant care. These patients experienced increased overall survival compared to standard adjuvant treatment alone.
Conclusion: Beneficial effects of integrative care were observed in this case series. Disease progression and symptoms related to adjuvant treatment were significantly decreased in these patients after integrative supportive care was initiated and effects persisted through the final observation period. Further controlled studies are needed among larger groups of patients to determine the clinical efficacy of medicinal mushrooms and integrative oncology in the treatment of RCC.


With the continuous development of imaging techniques, coronary computed tomography angiography(CTA) has become an important screening method for coronary heart disease and has been widely applied in clinical practice.But the high heart rate and arrhythmia have been considered as the bottleneck of the technology. With the rapid development of multi-slice spiral CT, high heart rate and arrhythmia are no longer contraindications for coronary CT examination.Moreover, we can obtain good image quality with reduced radiation dose. The research status and application progress of lose dose coronary CTA in patients with high heart rate and arrhythmia were reviewed.


Aiming at the limitation of traditional wavelet denoise effect, the relationship between stationary and classic wavelet is studied in detail.For the first time, the stationary wavelet is used to denoise the Gyro signal and compare with the result of classic wavelet.The experiment results show that the north finding accuracy by using stationary wavelet is obviously better than that by using classic wavelet.It also proves the better denoising performance of stationary wavelet.


From May to September 2011, a total of 138 wild rodents of the Cricetidae family were collected in the cities of Anhembi, Bofete and Torre de Pedra, in Sao Paulo State. All animals were examined for the presence of ticks, which were collected and identified at species level in the laboratory by morphological examination (for adults, nymphs and larvae) and molecular biology, by sequencing of a fragment of the 16S mitochondrial rDNA (for larvae). A total of 47 ticks (21 larvae and 26 nymphs) were collected from rodents, identified as 21 larvae and 23 nymphs of Amblyomma ovale (collected on Oligoryzomys nigripes, Oligoryzomys flavescens, Sooretamys agouya and Nectomys squamipes), two nymphs of Ixodes schulzei (O. nigripes and O. flavescens) and an Amblyomma sculptum nymph in S. agouya. The overall prevalence of parasitism by A. ovale was 4.3% for larvae, and 10.1% for nymphs. The mean intensity of parasitism was 3.5 larvae/parasitized animal, and 1.6 nymphs/parasitized animal. One O. nigripes was found parasitized by both larva and nymph of A. ovale, and another O. nigripes was parasitized simultaneously by an I. schulzei nymph and five A. ovale nymphs. This research reports the following unpublished records: A. ovale on O. flavescens, O. nigripes and S. agouya; A. sculptum on S. agouya; and I. schulzei on O. flavescens and O. nigripes.


The invention relates to a synergistic sterilization composition, particularly to a synergistic sterilization composition comprising epoxiconazole with increased effective quantity and any one sterilization active ingredient selected from flusilazole, triazolone, ethirimo, ziram, zhofigshengmyci, wuyiencin, pyraclostrobin, difenoconazole and iminazole.


The abuse of organophosphate pesticides and chemical-warfare agents has made severe effects on human and animal health. Consequently, it is vital to develop sensitive and selective strategies for the detection of organophosphates. In this work, the Tb(III) complex— TbL 3+ , consisting of a 1,4,7-triazacyclononane derivative as ligand was synthesized. As TbL 3+ contains no aromatic groups (function as an antenna), its intrinsic luminescence is thus minimized. The coordination of cyanophos to TbL 3+ could largely sensitize its luminescence ( I / I 0=55) because the energy of the triplet state of benzene is slightly higher in energy than the 5D4 of Tb(III). The detection limit for cyanophos was determined as 59 nmol/L. High resolution mass spectrum measurements, luminescence titration experiment and luminescence lifetime measurements reveal that TbL 3+ is bound with two cyanophos molecules and one methanol molecule. However, other organophosphates such as profenofos, chlopyrifos, dimethoate, diazinon, phoxim, fenthion, methyl parathion and dichlorvos almost did not induce any changes on luminescence intensity under the same conditions. By this work, we prepared a new luminescence probe for cyanophos with good selectivity and sensitivity.


Michael J. Henke and Craig D. Margolis* I. Introduction When the primary author first addressed the subject in 1992,1 video depositions were fast growing in popularity among practitioners and gaining greater acceptance by courts as a superior means of preserving live testimony for use at trial. In recognition of this trend, sweeping reforms in discovery practice occasioned by the 1993 amendments to the Federal Rules of Civil Procedure dramatically liberalized the rules governing the taking of video depositions.2 Where once video depositions were permitted in federal litigation only by stipulation or court order, new Rule 30(b)(2) grants the party noticing a deposition the right unilaterally to select the method by which the deposition will be recorded.3 As a result, the incidence of video depositions is sure to increase, both as a discovery tool and as a means of presenting evidence at trial. Indeed, one may speculate that at some point in the near future video depositions will become the rule rather than the exception. This Article will discuss in some depth the practice issues regarding the taking and use of video depositions, with a particular focus on the changes made by the 1993 amendments to the Federal Rules of Civil Procedure. II. Pre-1993 Rules and Practice In order to lay the groundwork for the discussion of video depositions after the 1993 amendments, a brief discussion of preamendment practice is in order. Until 1970, the Rules provided exclusively for stenographic depositions.4 The Advisory Committee circulated an amendment in 1967 that would have permitted the party noticing the deposition to designate the means of recording, either stenographic or non-stenographic.5 Deemed too controversial, this amendment was modified and adopted in 1970 to permit depositions to be taken "by other than stenographic means" upon motion and court order. Although one court of appeals held that a judge could not deny a request for a video deposition unless convinced "that the particulars of the request [did] not reasonably ensure accuracy equivalent to stenographic depositions,"7 the majority view was that judges enjoyed the same discretion in deciding whether to permit video depositions as they did in other routine discovery matters.8 The primary factor considered by courts in deciding whether to grant Rule 30(b)(4) motions was whether use of video would be cost-effective relative to other recording methods.9 Over time, the concept of video depositions became increasingly familiar, leading the Advisory Committee to circulate a second proposal in 1978 to amend Rule 30(b)(4) to permit unilateral noticing of video depositions." The drafters of that amendment believed that "given the reliability of modern electronic recording, the parties will normally agree to that method" and that "[t]he only objection available is to the accuracy of the electronic recording method to be employed."" As was the case a decade earlier, the Advisory Committee was somewhat ahead of its time. Controversy surrounding the amendment required retreat to a more modest proposal permitting non-stenographic depositions either by stipulation or court order.'2 Rule 30(b)(4) was so amended in 1980.13 The Advisory Committee indicated in 1980 that the purpose of the Rule 30 amendment was "to encourage parties to agree to the use of electronic recording of depositions so that conflicting claims with respect to the potential of electronic recording for reducing costs of depositions can be appraised in the light of greater experience."la Despite the resistance to amending the Rules to permit video depositions as a matter of course, judges and parties on the whole were relatively liberal in the use of video depositions.l5 Courts and commentators extolled the virtues of the video deposition.l6 While some courts remained recalcitrant by refusing to order videotaped depositions or admit video testimony,l7 the debate gradually shifted from whether to allow video depositions to what safeguards were necessary and proper to ensure their accuracy, fairness, and costeffectiveness. …


A hybrid drive unit for vehicles, in which a power distribution device is arranged in a power transmission route between an engine and a wheel, in which the power distribution device has a first to fourth rotary elements capable of rotating differentially with one another, in which a first motor generator is connected to the second rotary element and a wheel is connected to the fourth rotary element, and which is capable of steplessly controlling a speed change ratio of the first rotary element and the fourth rotary element of the power distribution device comprising: a second motor generator connected to the third rotary element of the power distribution device; a third motor generator connected to the wheel in a power transmittable manner; and an electric circuit for allowing exchange of electric power among individual motor generators.


PURPOSE: An illuminating apparatus using an LED is provided to protect an electronic component from external environment by combining a cover member and a cap with a heat sink. CONSTITUTION: A heat sink(10) has a semicircle pillar. First and second grooves are arranged inside or outside the heat sink. A substrate(31) is combined with the first groove of the heat sink. A plurality of LEDs(33) are mounted in one side of the substrate. A cover member(40) is combined with the second groove of the heat sink. The cover member passes the light emitted from the LEDs. The cap(51) is combined in both ends of the heat sink. The electrode terminal of the cap is electrically connected to a fluorescent lamp.


1. The metabolism of 4′-methoxy-α-pyrrolidinopropiophenone (MOPPP), a novel designer drug, to its demethylated major metabolite 4′-hydroxy-pyrrolidinopropio-phenone (HO-PPP) was studied in pooled human liver microsomes (HLM) and in cDNA-expressed human hepatic cytochrome P450 (CYP) enzymes. 2. CYP2C19 catalysed the demethylation with apparent Km and Vmax values of 373.4 ± 45.1 μM and 6.0 ± 0.3 pmol min−1 pmol−1 CYP, respectively (mean ± SD). Both CYP2D6 and HLM exhibited clear biphasic profiles with apparent Km,1 values of 1.3 ± 0.4 and 22.0 ± 6.5 μM, respectively, and Vmax,1 values of 1.1 ± 0.1 pmol min−1 pmol−1 CYP and 169.1 ± 20.5 pmol min−1 mg−1 protein, respectively. 3. Percentages of intrinsic clearances of MOPPP by particular CYPs were calculated using the relative activity factor (RAF) approach with (S)-mephenytoin-4′-hydroxylation or bufuralol-1′-hydroxylation as index reactions for CYP2C19 or CYP2D6, respectively. 4. MOPPP, HO-PPP and the standard 3′,4′-methylenedioxy-pyrrolidinopropio-phenone (MDPPP) were separated and analysed by liquid chromatography–mass spectrometry in the selected-ion monitoring (SIM) mode. 5. The CYP2D6 specific chemical inhibitor quinidine (3 μM) significantly ( p<0.0001) inhibited HO-PPP formation by 91.8 ± 0.5% (mean ± SEM) in incubation mixtures with HLM and 2 μM MOPPP. 6. It can be concluded from the data obtained from kinetic and inhibition studies that polymorphically expressed CYP2D6 is the enzyme mainly responsible for MOPPP demethylation.


The purpose of this study is to examine whether mandated introduction of Public Company Accounting Oversight Board in United States of America improves the audit quality for listed companies. The empirical analysis includes the companies listed in NASDAQ stock exchange that constitutes 6,600 firm-year observations for the period from 2008 to 2015. The paper use Modified Jones model to estimate signed discretionary accruals and unsigned discretionary accruals as a proxy for audit quality. It is found that Public Company Accounting Oversight Board improves audit quality and the relationship between abnormal audit fees and audit quality is asymmetric and conditional upon the sign of abnormal fees. It reveals that there is a significant difference between the impact of negative abnormal audit fees and positive abnormal audit fees on audit quality at least in case of unsigned discretionary accruals. The paper admits that the empirical analysis does not capture all the variables to observe the matrix; however, sensitivity analysis is attempted to check the accuracy of the results.


Telescopes are traditionally built and operated on earth. Others are built for operation in space. For both environments much of experience and data are available, which allow for a relatively straight-forward design. Not so an airborne telescope, which will be used not only for science but also for public outreach--a great idea, realized with SOFIA, the Stratospheric Observatory for Infrared Astronomy--with the consequence, that school classes will fly with the observatory. Therefore the telescope must be aircraft certified by the FAA, the Federal Aviation Administration, because it is part of the cabin pressure vessel. Also the environment for the telescope in the open cavity of the observatory aircraft is unfriendly compared with other telescope environments. It is surrounded by aircraft vibrations, high frequent excitations by air turbulence and temperature differences of 70 degree(s)C between the mirrors and the location of the science instruments. The paper explains the major design features of the SOFIA telescope, which are dominated by the harsh requirements.


We thank Dr. Bruno for the comment on our article.1 Although our focus was on how the ordinal and dichotomous forms of the 3-month modified Rankin Scale (mRS) relate to long-term outcomes and costs, we did exclude patients with prestroke mRS >1 and >2 to verify our findings in additional analyses. We agree that there is a need to establish more uniform methods for ascertainment of prestroke disability, which currently relies on measures like the mRS that were not originally designed for this purpose and may be vulnerable to confounding factors, such as sex differences in premorbid mRS ratings.


(To be updated once all other sections have been updated) 1. For more detailed discussion of Valle's equation and application, see: Garrison (1981) : Centreline velocity gradients for plain and flanged local exhaust inlets, American Industrial Hygiene Association Journal, 42:10, 739-746 A detailed discussion of Dalla Valle's equation and application is presented in Appendix D. 2. Buoyancy Theory ... The difference in dP between 6.0 and 9.3C would be (To-Ti)/(To+273.15). If To=, then dP=to or a % increase/decrease. So how would this affect volumetric flow rate? The following text has been added : "The density difference can be calculated from Equation 12 ( (CIBSE, 2005):   ) 15 . 273 ( int 0     out out T T T   ... Equation 12


In vehicular edge network, the mobility of vehicles will have a great impact on the optimal placement of cache content. At the same time, if the vehicles that need to update the cache content are not selected properly, it will bring a large energy loss to base station(BS). Therefore, this paper first proposes a vehicle selection strategy, which determines which vehicles need to be updated by prioritizing the vehicles. Then, considering the mobility and randomness of vehicles, this paper presents an problem to minimize the average energy consumption of base stations BS. The problem is transformed into the maximization of monotonic submodular function under matroid constraint, and it can be solved by greedy algorithm. Finally, the experimental results verify the effectiveness of the scheme.


A synthesis of results of the recently introduced paradigm of multi-adjoint logic programming is presented. These results range from a proof theory together with some (quasi)completeness results to general termination results, and from the neural-like implementation of its fix-point semantics to the more general biresiduated multi-adjoint logic programming and its relationship with other approaches.


We report on our experience treating children with peritoneal mesothelioma harboring anaplastic lymphoma kinase (ALK) gene mutations. Rare in children, we believe that the biology and clinical course are different from those in adults.


Based on the analysis of a specific relay model and an HVAC (High Voltage Alternating Current) cable system, a new approach to EMTDC/PSCAD modelling of protective relays is presented. Such approach allows to create complex and accurate relay models derived from the original algorithms. Relay models can be applied with various systems, allowing to obtain the most optimal configuration of the protective relaying. The present paper describes modelling methodology on the basis of Siemens SIPROTEC 4 7SD522/610. Relay model was verified experimentally with its real equivalent by both EMTP-simulated and real world generated current signals connected to the relay.


The Diels-Alder reaction of menthyl (Z)-(S) s-3-(2-pyridylsulfinyl) propenoate with cyclohexa-1, 3-diene in the presence of a Lewis acid, zinc bromide, afforded the endo cycloadduct in a highly diastereoselective manner in excellent yield. The absolute stereochemistry of the adduct was determined by transformation into (+)-bicyclo [2.2.2] oct-5-ene-2-endo-methanol with known absolute configuration.


Grona Taget (English: Green Train) is a research and development programme, the aim of which is to define a concept and develop technology for future high-speed trains for the Nordic European marke ...


The π-π * charge-transfer comples, C 13 H 4 N 4 O 9 .C 12 H 12 , stacks along the c-glide direction with the pair of molecules essentially parallel and at a van der Waals distance. The carbonyl vector in tetranitro-9-fluorenone (TNF) makes an angle of approximately 57 o with the briding C atoms in the 2-ethylnaphthalene, while the corresponding angle in the 1-ethylnaphthalene complex is 170 o


Major Drosophila opsin (Rhl) has two potential glycosylation sites at Asn-20 and Asn-196. However, no sugar chains are bound to these sites in mature opsin. Recently, we found an intermediate of opsin in post-translational processing . Since this intermediate is glycosylated, it has been suggested that elimination of sugar chain occurs during the maturation of opsin. In order to examine the process of glycosylation and deglycosylation of opsin peptide in vitro, we synthesized the opsin in a cell-free translation system of rabbit reticulocyte lysate. In the absence of pancreatic microsomal membranes , a single type of opsin peptide (Mr=36k) was synthesized. On the contrary , three types of opsin peptide with different MW (36k, 40k, 43k) were synthesized in the presence of the microsomal membranes. Digestion of N-linked sugar chain with peptide N-glycosidase F caused the reduction of the apparent MW of 40k and 43k opsins to 36k. This result indicated that both 40k and 43k opsins are Nglycosylated, but 36k opsin is not. We next constructed two mutant genes of opsin, those cause the substitution of Asn-20 and Asn-196 to Ile, respectively (N20I and N196I). In each mutant, only a single potential glycosylation site remained. Using these mutant genes , we synthesized opsin in vitro in the presence of microsomal membranes. In both N20I and N196I, 36k and 40k peptides were synthesized , but 43k peptide was not produced. It is, therefore, clear that 43k opsin has two sugar chains, and 40k opsin has one at Asn-20 or Asn-196. In N20I, however, the amount of 40k was much less than that of 36k peptide. This result indicated that glycosylation of Asn-196 was extremely suppressed in the absence of Asn-20 (N20I). This also suggests that the sugar chain at Asn-20 might induce the incorporation of opsin peptide into microsomes, which then resulted in the glycosylation of Asn-196. The present results and discussion do not conflict with the hypothesis that the 40k intermediate of opsin in vivo has a single sugar chain at Asn-20, and that the sugar chain might play an important role in the translational process of opsin.


The study examines the concept of László Németh's high-impact "Garden Hungary". The article seeks to answer the question of how successful Németh's third-way vision was in formulating an alternative to solving the problems of modern Hungarian social development. In doing so, the work discusses how the idea of a quality revolution, which is at a distance from the development of both Western and Eastern European societies, was intended to transform Hungarian society. In addition, the study analyzes the virtues and pitfalls of the approach built on agriculture and focusing on the intellectuals. At the end of writing, the paper compares László Németh's concept with the contemporary reform proposals, so that we can judge the approach more realistically by interpreting it in his own social context.


"Disembodied voices" is an interactive environment designed for an expressive, gesture-based musical performance. The motion sensor Kinect, placed in front of the performer, provides the computer with the 3D space coordinates of the two hands. The application is designed according to the metaphor of the choir director: the performer, through gestures, is able to run a score and to produce a real-time expressive interpretation. The software, developed by the authors, interprets the gestural data and controls articulated events to be sung and expressively performed by a virtual choir. Hence the name of the application: you follow the conductor's gestures, hear the voices but don't see any singer. The system also provides a display of motion data, a visualization of the part of the score performed at that time, and a representation of the musical result processed by the compositional algorithm.


The goal of this Special Issue is to report new research progress and reviews concerning amyotrophic lateral sclerosis (ALS) [...].


Hydrothermal methods were used to prepare doped LiMxMn1-xO2(M=Mg,Y,Zr) as cathode materials for lithium-ion batteries. The structure and morphology of the as-prepared cathode materials were characterized by X-ray diffraction(XRD) ,transmission electron microscopy(TEM) and X-ray photoelectron spectroscopy(XPS) . The effects of ion doping on the performance of orthorhombic materials was analyzed in terms of their crystal structure,charge-discharge curves,cycle performance and electrochemical impedance spectroscopy(EIS) . Results show that the doped materials had better cycle performance. In particular,the discharge capacity of Li0.99Mn0.979Y0.021O2 remains 226.3 mAh· g-1 after 60 cycles with a current density of 50 mA·g-1 at room temperature.


526/ASQ, September 2010 In previous eras of economic struggle one might have heard admonitions to "put your nose to the grindstone" or to "work smarter not harder." Increasingly, however, business and policy leaders argue that creativity, rather than sluggishness or ineffi ciency, is the critical ingredient needed to boost regional economies, address societal problems, fi x institutions, and renew corporations. The editors of this volume seek to improve our understanding of creative economies by addressing tensions inherent in the "contemporary economic nexus," where artistic sensibilities meet economic logics. They have assembled thirteen original contributions that describe various facets of knowledge work and idea generation in the context of organizations participating in creative or cultural industries. In these settings, creativity is viewed as a necessary and, perhaps ironically, routine process rather than as a specialized, episodic input isolated from an organization's day-to-day operations.


We report a case of a 65-year-old female presenting with an Anterolisthesis grade I, L5-S1. With a history of lower back pain that started two years ago with weak big toe extension. CT scan revealed that There is anterolisthesis grade I, L5-S1. No pars defect was seen, and degenerative changes in the bilateral facet joint L5-S1, with narrow joint space & sclerosis. The patient underwent conservative management to strengthen and stretch her back muscles for three months and had spontaneous fusion develop at an unstable level with relief of symptoms after nonoperative treatment.


Interactive text visualization can help users explore and gain insights into complex and often large document sets. One popular visualization strategy to represent such collections is to depict each document as a glyph in 2D space. These spaces have proven effective, especially when combined with interactive exploration methods. However, current exploratory approaches are largely limited to single areas of a 2D spatialization, lacking support for important comparative exploration and analysis tasks. In this paper, we extend a flexible focus+context exploration technique to tackle this challenge. In particular, based on practical tasks from the digital humanities, we focus on exploring and investigating relationships between entities in large document collections. Our approach uses natural language processing to extract characters and places, including information about their relationships. We then use linked views to facilitate visual analysis of extracted information artifacts. Based on two usage scenarios, we demonstrate successful applications of the approach and discuss its benefits and limitations.


This paper develops a monitoring system of machining environment,which contains cameras,DM642 development board and computer application. By optimizing digital image processing and recognition algorithms,the digital instrument of machine associated equipment are recognized in real time,besides, machining environment and actual status parameters are accurately detected. The computer application communicates with DM642 through ethernet,so that the machining environment is remotely monitored, and information management of machining environment is facilitated.


Early one morning I was almost the only passenger—sorry, customer—in the carriage as the train left Edinburgh. "I will look after you, sir," said the young steward with a faint accent. "I will keep serving complimentary coffee. When you are pissed off, let me know and I will stop."

Charmed, I hadn't the heart to explain that in first class we become "replete," not "pissed off." I assumed he was European—unlike most train staff, who are British, or most pub staff, who nowadays are Australian. One of the many good things about antipodean barpersons is they rarely swear at the clientele.

Our hospitals too used to be full of young Australians—but, increasingly, junior doctors are from mainland Europe. A nursing colleague commented that they were good clinicians and excellent record keepers. The only trouble was the swearing. She had recently had to rebuke one for using bad language in front of a patient.

I can sympathise with that doctor. Anyone coming here to learn colloquial English is likely to end up—how you say?—bloody confused. British bookshops are full of the works of Irvine Welsh. Our films, however frothy, are scattered with four-letter words, and even the BBC loses its gentility after 9 pm.

Foul language has spread from Billingsgate to Hampstead and from low tavern to smart bistro. I find it appalling to hear a well dressed woman effing into a mobile phone or—the other day in our hospital corridor—a dad chatting to his little daughter with throwaway obscenities.

Maybe it's being a gynaecologist that makes me so fastidious. Centuries ago, oaths used to be religious. "Cor blimey" ("God blind me") or "'Od's bodkins" (translation mercifully obscure) must once have had great shock value, carrying a real risk of damnation. Nowadays all our swear words relate to pelvic anatomy and physiology. Paradoxically, the only place guaranteed free of them is the gynaecology clinic.

Or perhaps it's my age. As an enfant terrible on committees I used to swear from time to time with what I imagined was telling effect. A grey beard makes this inappropriate, and looking back I doubt that it was ever necessary. Nowadays I have to do it alone in the car, like everyone else.


The paper presents a fragment of a research project aimed at defining the dynamics and tribology of the real twisting system of a ring spinning frame, i.e. a system with regular and/or random occurrence of faults in its operation. The object of study are the dynamic disturbances and their tribological consequences, which occur in the operation of the twisting system of a worsted spinning ring-frame due to faulty rotation of the spindle caused by play in its bearing. Studied was a twisting system provided with a taper ring (HZ) and T steel traveller. The forces were determined, for a case of three-contact inter-action between the traveller and ring, which act on the traveller and yarn if the spindle axis deviates from the vertical so that its tip traces an ellipse or a circle. It is shown that this faulty operation of the twisting system has a destructive effect on the inter-action of the traveller-ring-yarn (TRY) trio, which aggravates with time and has a deteriorating effect on the performance of the system


With the development of urbanization the urban water demand is keeping increasing, meanwhile water pollution becomes more serious. Now there's more and more water resource or water quality-induced water shortage , therefore the traditional or present concept on urban water supply and drainage planning could not satisfy the demand to protect the urban water resource and regional natural water environment. In the paper the new concept on urban water supply and drainage planning is proposed so as to set up the modern urban water and water drainage planning concept and make the basis for realization of energy-saving and emission-reduction and the construction of resource-saving and environmental-friendly city.


The performance of molybdenum carbide catalyst for partial oxidation of methane to syngas has been evaluated in a micro-reactor under various conditions. The molybdenum carbide catalyst is stable in methane partial oxidation to syngas at high reaction temperatures, high pressures and with a low space velocity of reactants. Pre-treatment has a significant effect on the catalyst activity and selectivity. The reaction mechanism over molybdenum carbide has been studied using 13C isotope exchange and in situ laser Raman. It is seen that the carbon in the lattice of the molybdenum carbide takes an active part in the reaction. The deactivation of molybdenum carbide catalyst results from the oxidation of the catalyst surface.


Ret transgenic mouse model of skin malignant melanoma is characterized by the overexpression of the human ret transgene in melanin‐containing cells. Transgenic mice spontaneously develop skin tumors with metastases in lymph nodes, lungs, liver, brain, and the bone marrow. Tumor lesions show typical melanoma morphology and express melanoma‐associated antigens. Although transgenic mice demonstrate an accumulation of melanoma antigen‐specific memory and effector T cells, their anti‐tumor effects could be blocked by highly immunosuppressive leukocytes enriched in the tumor microenvironment and in the periphery. Here, we discuss the role of one of the most potent immunosuppressive subset, regulatory T cells, in the melanoma progression in this model.


Using laser accelerated protons or ions for various applications\char22{}for example in particle therapy or short-pulse radiographic diagnostics\char22{}requires an effective method of focusing and energy selection. We derive an analytical scaling for the performance of a solenoid compared with a doublet/triplet as function of the energy, which is confirmed by TRACEWIN simulations. Generally speaking, the two approaches are equivalent in focusing capability, if parameters are such that the solenoid length approximately equals its diameter. The scaling also shows that this is usually not the case above a few MeV; consequently, a solenoid needs to be pulsed or superconducting, whereas the quadrupoles can remain conventional. It is also important that the transmission of the triplet is found only 25% lower than that of the equivalent solenoid. Both systems are equally suitable for energy selection based on their chromatic effect as is shown using an initial distribution following the RPA simulation model by Yan et al. [Phys. Rev. Lett. 103, 135001 (2009].


Cardiovascular Research accepts submissions of original papers from the entire realm of cardiac and vascular basic science. And indeed, the submissions show a large diversity of topics. The elaborate review process involving experts in the various specific fields of research is the deciding factor that determines the selection of papers finally published. It is generally assumed that in the long run the accumulating citations of a published paper in other qualified scientific journals can be taken as a sign of its lasting scientific value. Citations do not, however, reflect the immediate awareness, i.e. the 'news value' of the topic of a given article. In times of electronic journal usage, this immediate interest ignited by a given publication in the scientific community can be estimated from its early electronic usage by tallying the number of times an article is downloaded online. The editors of Cardiovascular Research use the download information regularly to follow quick trends of interest in their readership. Here we report on the 10 most-downloaded original articles from January 2009 to July 2010. We counted the downloads of full-length articles for a window that included the electronic in-press period and the 2 months following appearance in print for each paper. The newest articles we evaluated are from July 2010.

With the same method, we also evaluated the downloads of review papers during this period. Clearly, the download statistics of reviews does not reflect …


College English teaching mainly focuses on EGP,ignoring the importance of ESP. This paper analyzes the current situation of college English teaching,proposes that college English reform should transit from EGP to ESP and puts forward corresponding strategies. This teaching mode is conductive to the cultivation of students.


The invention relates to a synthetic insulator used for power line. A method for connecting the core rod of the synthetic insulator with amour clamp, characterized in comprising the steps as follows: 1) coating metal cone sleeve at the end of the core rod; 2) jacketing wedge ring at the end of the core rod; 3) keeping the axial positions of the core rod and wedge ring fixed, making the metal cone sleeve apply axially outward pulling force (F1), move on the wedge ring and tighten up the wedge ring so as to clamp the core rod; 4) connecting external armour clamp with the outer end of the metal cone sleeve through screw thread.


The current investigation aims to study Soret and Dufour effects on MHD flow near stagnation point through a heated stretching sheet including the impact of radiation and chemical reaction. Similarity transformations are adopted to covert the governing equations to nonlinear ODE's. Numerical approach has been adopted to solve the equations using MATLAB's solver bvp4c. The graph of velocity, temperature, and concentration distributions are obtained for different parameters. In order to know the precision of the numerical solution, comparison has been made between the current outcomes and the outcomes present in the literature and the outcomes show fair agreement. Soret and Dufour effects affect the species concentration and fluid temperature to a significant extent as the former raises the species concentration close to the surface of the stretching sheet and the latter increases the temperature of the fluid. corresponding author 2020 Mathematics Subject Classification. 76D05, 76S05.


Objective
To help medical students better understanding the clinical significance and the mutual relationship of laboratory tests, and to improve their ability on analysis and application of laboratory tests.

Methods
38 foreigner medical students who started their clinical course in Civil Aviation General Hospital in 2012, 2013 and 2014 were chosen to try CBL-PBL teaching method. Self-designed evaluation sheet was used to collect the feedback from students and teachers.

Results
All students presented a welcome attitude on CBL combined with PBL teaching method, they liked to share what they have learned. Selection of case, refinement of problem, design of class, professional quality of teacher and the preparation situation of student all had influence on the teaching efficiency. Appraising through case-analyzing tests, it showed that students could understand and utilize the laboratory tests well which they studied in the class.

Conclusions
CBL combined with PBL teaching method can help student better understanding the utilizing laboratory tests.

Key words:
Case-based learning; Problem-based learning; Laboratory diagnostics; Effect


1Department of Pharmacy, Xinagya Hospital, Central South University, Changsha, 410008, People's Republic of China; 2Department of Medical Oncology, Lung Cancer and Gastrointestinal Unit, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, People's Republic of China; 3Hunan Clinical Research Center in Gynecologic Cancer, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya School of Medicine, Changsha, 410013, People's Republic of China; 4National Institution of Drug Clinical Trial, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China Purpose: To investigate the relationships between Wnt1 inducible signaling pathway protein 1 (WISP1) polymorphisms and the prognosis of platinum-based chemotherapy in lung cancer patients. Patients and Methods: A total of 363 lung cancer patients were recruited in this study. All of them received at least two cycles of platinum-based chemotherapy. We used unconditional logistic regression analysis to assess the associations of 39 single nucleotide polymorphisms in WISP1 gene with platinum-based chemotherapy prognosis. Results: The results indicated that patients carried rs2929973 GT or GG genotypes had increased risk of disease progression (HR = 0.712, 95% CI = 0.553–0.916, P = 0.015). Patients with rs2977551 TT genotype had a significantly decreased risk of progression-free survival than patients carrying CT or CC genotype (HR = 0.723, 95% CI = 0.561–0.932, P = 0.032) and overall survival (HR = 0.725, 95% CI = 0.552–0.913, P = 0.045). For rs2977549, patients carrying TT genotype had a significantly longer progression-free survival than patients with CC or CT genotypes (HR = 0.708, 95% CI = 0.550–0.912, P = 0.017). Among of them, rs16904853, rs10956697, rs2929965, rs2929973, rs7828685, rs2977551 and rs2977549 were related to progression-free survival, and rs10956697 and rs2977551 were related to overall survival in subgroup analyses, respectively. Conclusion: WISP1 rs2929973, rs2977551 and rs2977549 may be contributed to a potential candidate biomarker for prediction of platinum-based chemotherapy prognosis in lung cancer patients.


The invention relates to a real-time measure method for the performance of multi-path photo-voltaic cell which comprises steps of: expanding measure channel via interface circuits and realizing measurement of multi-channel and continual real-time monitor of cell to get the aging characterization of photo-voltaic cell in long term working process; employing automatic control technology for real-time monitor on photo-voltaic cell and collection the light intensity and temperature of test environment. The invention has the advantages of being stable and reliable, and of being applied to the standard testing and aging testing of single and group photo-voltaic cells on process line.


We calculate the coupling parameters of several dibaryon resonances (B/sub 2/) to the ..pi..-d channel in terms of the more fundamental ..delta..N-B/sub 2/ and NN-B/sub 2/ couplings. We compare the results with values obtained from phenomenological fits and show that at least in one case (for the J/sup P/ = 4/sup +/ resonance at 2.48 GeV) the latter ones are not compatible with a deuteronlike structure of the dibaryon systems.


This paper discusses the undrained response and liquefaction of beach soil under triaxial loading. Numerical simulations of static undrained triaxial tests were performed using advanced hypoplastic constitutive relations. The response was studied by varying different test parameters. The results of test simulations are interpreted in terms of pore pressure buildup, stress path and stress-strain relations. Finally the static liquefaction resistance is evaluated based on stress ratio arrived at the stage of residual stage or the limited strain of 20%. The results obtained from this study can be applicable for the soil deposits nearby beach region contain poorly graded fine sand.


The inheritance of sterility as well as the morphological and cytological abnormalities associated with it were studied in three male lines of soybean viz: Semmes M.S.-l, Semmes M.S.-2 and N 69–2774.


A method to analyze the radiation of antenna window with medium embedded is presented. Medium is embedded in an antenna window to decrease the RCS of the antenna, while it influences the radiation of the antenna. The relation between the parameters of the medium and the radiation of the antenna is obtained using this method. Then the parameters of the medium embedded can be selected, such as thickness and permittivity, so that the medium has little influence on the radiating and feeding system.


The influence of transportation noise on the quality of life has so far been investigated by socio acoustical surveys, some of which have shown that noise annoyance is affected by not only noise exposure but also non-acoustical factors. Fields (1993) conducted meta-analysis on the effects of personal and situational variables on annoyance, in which he indicated that noise annoyance was strongly affected by three attitudes (fear, preventability, sensitivity) and weakly by situational factors but not by demographic factors (age, social status, etc.), exposure time, ambient noise and interview method. Miedema & Vos (1999) also pointed out that fear and sensitivity were important on the prediction of noise annoyance. Hong et al. (2007) also showed by ANOVA that sensitivity had a significant effect on sleep disturbance but sex and age of participants did not. Sandrock et al. (2008) demonstrated that people who are more sensitive to tram and bus noise gave higher annoyance at experimental study. On the other hand, using a magnitude estimation method in laboratory experiment, Ellermeier et al. (2001) showed that the degree of sensitivity did not affect response to noise. Though these studies were mainly related to sensitivity, there were a few other studies which investigated the influence of the attitudes towards noise sources. Since noise annoyance is usually affected by socio-cultural factors, investigating the effect of the attitudes on annoyance in Japan may be the key to find out the difference in dose-response relationships for transportation noises between Japan and Euro-American countries (Fields & Walker 1982; Knall & Schuemer 1983; Moehler 1988; Miedema & Vos 1998; Kaku & Yamada 1996 and Morihara et al. 2002). The purpose of this study is, therefore, to investigate whether the attitudes, in terms of the frequency of noise source usage, cognition to noise source and safety image of noise source, affect noise annoyance.


This thesis examines the International Alternative Economy for Women. With a research centered around the concepts of Fair Trade, Micro-credit, Social Enterprise, its main focus is to illustrate how international Alternative Economy affects women's life. The research shows that the above three concepts have been useful in the improvement of females' economy conditions as well as their social positions more or less. In case of Fair Trade, although its affect is minor, a direct transaction of small-scale producers in under-developed countries with consumers in developed countries has made their life better. In case of Micro-credit, lenders for those whose life with low income can not be subsidized by commercial bank have given loans to help poverty females. This has led to the improvement of their abilities of self-supporting economy activities. In case of Social Enterprise aiming social welfare, hiring socially isolated and under-privileged low income people has made their life better as well as increased firms' profits. In addition to the above benefits, it has also helped diminish welfare expenses. In addition, this study has discovered that a producer group of Fair Trade was connected with Social Enterprise and especially with Micro-credit. The lenders have also given loans to Social Enterprise. In conclusion, this Alternative Economy has improved the situation of female economy as well as their positions and women's power at their families. This has resulted in elimination of women's poverty.


The NRV web knowledge base on low-energy nuclear physics has been created in the Joint Institute for Nuclear Research. This knowledge base working through the Internet integrates a large amount of digitized experimental data on the properties of nuclei and nuclear reaction cross sections with a wide range of computational programs for modeling of nuclear properties and various processes of nuclear dynamics which run directly in the browser of a remote user. Today, the NRV knowledge base is a powerful instrument for nuclear physics research. The basic principles of the NRV knowledge base are covered, and a brief description of its structure is given. The practical usage of the NRV knowledge base for both scientific and educational applications is demonstrated in detail.


Research paper presenting findings of the UK Copyright Literacy Review and its implications on the measurement and management of copyright support within institutions.


The transmitted signal is assumed to consist of a close succession of rectangular pulses of equal width. A matched filter scheme is employed and a theory is developed for a computer-aided optimization of the envelope of monotone compact signals for maximum rejection of dense clutter of any given distribution in range. Specific results are presented and indeterminate cases are discussed.


The transition of a buoyant plume from an open cavity heated from below is studied by using numerical simulation. A small range of Rayleigh numbers from 10 to 10 and aspect ratio of A = 1/2, and Prandtl number of Pr = 0.7 (air) is considered. The plume from an open cavity heated below approaches a periodic puffing state around the Rayleigh number 8.6×10, it suggests that the plume from the open cavity heated below undergoes a supercritical Hopf bifurcation from a steady flow to a periodic flow. The following results reveal that there exists a series of period-doubling bifurcations after the Rayleigh number exceeds 8.6×10. Moreover, the phase pictures are displayed to understand the period-doubling bifurcations further. The understanding of the transition of buoyant plumes from a threedimensional open cavity is of practical importance for the design of various systems such as smoke exhausts.


A virtual machine live-migration improvement based on hybrid-migration was presented to improve the efficiency of the backup for virtual machines(including the running-state,storage and configurationinformation),stability of the running virtual machines and the balance for physics machines.Shared storage migration and storage block migration were blended to balance the speed for live-migration of virtual machines in the validity of backup.The practical result showed that the proposed virtual machine livemigration improvement solution can effectively improve the efficiency of the backup for virtual machines,reduce the time of live-migration and improve the fault-tolerant ability.


Purpose – The purpose of this paper is to examine how to successfully blend an e‐learning module into a knowledge management (KM) course aimed at getting KM students interested in the respective subject matter (= KM) in a web‐based learning environment.Design/methodology/approach – Based on data obtained from 138 undergraduate business management students at a university in Singapore, practical aspects of effectively implementing an e‐learning system with a focus on KM are analyzed and the importance determined of three conceptual variables in the context of successful blended learning approaches: online faculty to student interaction, social presence and personal e‐learning experiences.Findings – The study shows some positive correlations between online faculty to student interaction, the degree of presence in a web‐based learning environment, as well as personal e‐learning experiences as potential drivers of students' desire to learn more about the subject matter KM.Research limitations/implications – T...


A structured approach to debugging is presented based on restricting the class of programs that can be written. This is achieved by defining a domain specific language, eliminating control flow by using aggregate operations and eliminating side effects by using an applicative language as a base. The domain specific language is realized by defining domain specific operators as extensions to the base language; a set of operators are defined in the paper for data processing applications. The debugging strategy consists of setting up a sequence of input/output transformations; this process takes the input to the output in partial stages so that the correctness of each transformation relative to its input and output set can be verified. The approach is illustrated by a simple data processing problem.


As radiologists, one of the frequent problematic diagnostic dilemmas we face is trying to distinguish a benign from malignant fracture. Often I find myself feeling embarrassed when reflecting upon my response to a clinician when posed with the question, "Is this vertebral fracture benign or


Two important issues need to be emphasized. First, although the bulk of this guide addresses more common problems leading to discipline—e.g., poor work performance or poor attendance—there are times when major infractions occur that require moving immediately to a suspension or discharge. There are also times when a step may be repeated or skipped. To assure appropriate and timely action, you should contact your divisional human resources staff or human resources manager. Second, consideration of the individual's level of responsibility or type of position within the university is critical in applying the concepts of progressive discipline in any given case.


In this paper, we summarize the performance of a diamond cooled diode pumped solid state (DPSS) Nd:YAG laser developed by Textron Systems Corporation (TCS). Over 50% intrinsic extraction efficiency at 50-Watts average power, equivalent to volumetric power extraction of 2000 W/cc, has been experimentally demonstrated. Beam quality (BQ) of less than 1.1 XDL has been measured in an oscillator configuration with the laser operating in TEM00 mode. With a simple passive thermal lens correction, BQ of less than 1.5 XDL was obtained from an oscillator amplifier arrangement at specific pump rates up to 1600 W/cc and 600 W/cc, respectively. By using an intra-cavity acousto-optic modulator, Q-switched laser pulses as short as 6 ns were obtained from the oscillator. This concept is amenable to scaling up to very high power levels. A conceptual design, using our validated database, for a 100-kW class laser is also presented.


The invention provides a data security control method of a storage device. The storage device comprises a storage unit and a communication interface unit. The method comprises the following steps: formatting the storage unit, wherein the formatted storage unit comprises a data access block and a secret key block; receiving the encrypted secret key set by the user via the communication interface unit; when the encrypted secret key set by the user is received, encrypting the data in the data access block according to the received encrypted secret key and storing the received encrypted secret key in the secret key block; receiving the decrypted secret key input by the user via the communication interface unit and verifying the validity of the received decrypted secret key according to the encrypted secret key stored in the secret key block; and when the received decrypted secret key is valid, decrypting the data in the data access block according to the received decrypted secret key. The invention also provides the storage device.


The vulnerabilities existed in Korean electricity control systems is unexposed because it is being operated in a closed network with superior security. The threat will become greater once the closed network develops into a smart grid environment with superior intelligence. Security will have a greater impact once each household will be connected to the power plant via the smart meter. This research focuses on stable data transfer in harsh external environment and whole-nation coverage network, and suggested standardized and optimized Virtual Private Network (VPN) Gateway architecture to support Power Line Communication (PLC). The functionality and stability of the prototype has been verified with field tests. For implementation of outdoor type VPN device for smart grid, we adopted PLC low voltage remote-meter-net for data communication. Also, IPSec type tunneling and ARIA algorithm based encryption of data collected by PLC low voltage remote meter is transmitted.


Fresh Juice Incorporated (FJI) is in the process of determining whether it should launch a new fruit juice, Genetically Enhanced (GE) Juice. The GE Juice meets consumers' demands for a tasty, nutritious product and it would be the first new juice product in the last fifteen years. Before FJI decides to launch GE Juice, it must analyze the uncertainty surrounding market size, market share, and price of GE Juice. Finally, if FJI decides to launch GE Juice, then they must decide if they will bottle the juice themselves or outsource this process. This case teaches students how to discuss the strategic implications of launching a new product and develop a net present value and financial feasibility simulation model given limited information. Copyright 2008, Oxford University Press.


In 5G communication system, the application of massive Multiple Input and Multiple Output (MIMO) technology makes it possible to transmit a plurality of narrow Transmitting (Tx) beams at eNodeB side. Each Tx beam may be applied to each Beam Reference Signal (BRS), which can be used by the User Equipment (UE) to accomplish beam tracking. In addition, a UE could also contain massive antennas and maintain several Receiving (Rx) beams, and it should measure all possible Tx beams or Tx-Rx beam pairs to determine the best one. The beam tracking process could result in an unacceptable delay, which is determined by the number of Tx and Rx beams. In this paper, an improved method is proposed which could reduce search delay further at the cost of energy loss. In addition, an optimized method for Tx beam pattern design is presented to reduce the performance loss with fast search. Simulation results show that with the help of the optimized Tx beam pattern, the performance of fast beam search method could be improved significantly.


More than 100 HIV-related groups, including ACT UP, have endorsed the Fair Pricing Consensus Statement, which requires DuPont to reduce the price of its non-nucleoside reverse transcriptase inhibitor (NNRTI) Sustiva. Sustiva costs nearly twice as much as other NNRTIs. This high cost makes it difficult for programs to support the drug and for individuals to afford it.


Urbanization and industrial agglomeration are the two developmental trends in an economic society,and there is an inseparable relationship between them. In this paper,both theoretical and empirical approaches are applied to conduct an analysis of the correlation between them. The result indicates that there exists the relationship between them for mutual promotion. By means of element agglomeration,optimization and upgrading of industrial structure,the enhancement of the urban competitiveness,and other ways,industrial agglomeration promotes urban development. In return,urbanization promotes industrial agglomeration through a number of approaches such as upgrading of endowments,infrastructure construction and creation of the institution environment. Finally,the paper puts forward some proposals to promote the coordinated development of both of them.


This cross-sectional survey study aimed to examine and describe current job placement situation of two year graduates from 32 colleges under Praboromarajchanok Institute (PI). A set of the survey questionnaires was sent to 4,000 graduates by mail in 2012 and 1,467 copies were returned to be the samples. Data were analysed by using descriptive statistics, frequency, percentage, mean, standard deviation, and Pearson Product Moment Coefficient. The major findings of the study were: (1) Most of the graduates could get the job corresponded to the courses graduating. Particularly, those were finished in a Bachelor of Nursing Science programme could get nursing job for 100%. The majority worked in community hospitals, 53.01%, followed by regional hospitals, provincial hospitals, and primary health care hospitals as19.19%, and 13.46%, respectively. However, 87.7% of the graduates were hospital employees. Only 7.4% could be government staff members. Overall, 92.79% of graduates from this institute could not find a government staff position, especially those who worked as correctional pharmacy, correctional medical service emergency management, and official audio; (2) The graduates who worked as a government staff member could have a ranging salary from 9,001 to 10,000 Baht. This amount was quite less compared to ones who were not. Most of them got their income ranging from 11,001 to 15,000 Baht. The graduates rated job satisfaction in the mode of their colleagues at a highest level (X=3.75,SD=0.73), followed by their work places (X=3.66,SD=0.68), whereas the incomes, job position, and career advancement were rated at a low level (X=2.68-3.03,SD=0.84- 1.00), and (3) If possible, 57.7% of the graduates needed to change or quit their current work. The job changing plan and career advancement were statistically negative significant with job satisfaction, (r=ranging from-0.404 to -0.364), p. <0.01. Those who were not government staff members were tend to leave their work more than the others. The results indicated that being a government staff member mostly influenced the graduates' job remaining. This could be significant information for further workforce development of PI and Ministry of Public Health. Particularly, the departments have to not only plan for health workforce production, but also maintain manpower in the health system. Key words: job placement, graduates, health manpower, government staff member


The paper combines intentionalist with functionalist approaches to the Nazi genocide on Gypsies, arguing for a differentiated interpretation of the processes that led to the genocide. A cricital position is taken with regard to the adoption in the context of the Nazi persecution of Gypsies of the 'Jewish narrative', which is based on the intentionalist interpretation, and the idea is challenged that identical motives were behind the persecution of Jews and Gypsies.


Each color chip of the OSA Uniform Color Scales set (1) is intended to represent a color which, under the appropriate viewing conditions, is subjectively equidistant from its nearest neighbors in a 3-dimensional Euclidean space. To the extent this is so, the 424 chips of the set define -- and at the same time sample -- a space that is isotropic with respect to color differences. The three dimensions of the OSA space, called L, j, and g, permit the color chips to be labeled with triplets of values that can be positive or negative relative to 0,0,0, for which there is a chip intended to be a middle gray. L represents a lightness axis, ranging from very dark at the bottom to very light at the top. J and g are chromatic axes (roughly yellow(+)/blue(-) and green(+)/red(-) respectively); these are orthogonal to each other and to the L axis.


Usually data warehouses store a large volume of data, keeping in their structures all information decision-makers need on their daily activities. Usually, a significant amount of this information is processed and materialized in data cubes to be explored latter using the most flexible ways that on-line analytical processing platforms dispose to do that. However, this materialization process requires a lot of computational resources (processing time and storage), provoking as well serious performance bottlenecks in analytical systems. The distribution of such analytical structures across an organization seems to be quite appellative to attenuate such annoying effects, being in most of the cases a good alternative for improving system performance without great expense. Still, a distributed computational platform use to be less expensive than a centralized one, what give it some good advantages in any solution related to data cube distribution. Following this slope appears Grid environments. As we know these can use computational resources geographically dispersed, heterogeneously and non-dedicated as it was a single a unique environment. However, in order to reach higher performance levels, Grids need proper scheduling and data so they can be able to respond effectively to the jobs that were sent to them. In this paper, we integrate a performance prediction method in a data cube distribution strategy to define a more effective allocation of data cube views in a conventional Grid environment with the ability to receive them.


The emergence of an international law of human rights' has substantially complicated the application of international law by U.S. courts. In the past, when international rules were thought only to affect relations between sovereigns, domestic courts could limit their application to situations involving one nation's infringement of another's rights. Such sovereign rights were well-established by practice, conventions, treaties, and scholarly writings.2 The recognition, following the genocides of this century, of human rights as a subject of international law has made the protection of international law available to numerous non-sovereign parties that did not enjoy it before. 3 At the same time, however, it has


The development of the gravity gradiometer is described simply in this paper,and the measuring principle and development experience of the rotating accelerometer gravity gradiometer are emphatically discussed.On the basis of researches on the existing airborne gravity gradiometer,the prospects of the airborne gravity gradiometer are also presented.


Especially in North America, trademark litigation constitutes a prominent area of applied linguistics. As legal consultants, linguists bring their professional expertise to bear upon three issues: (1) likelihood of confusion of two marks; (2) categorization of the strength of a mark with respect to its place on a continuum of semantic/pragmatic categories technically labeled "generic," "descriptive," "suggestive," "fanciful," and "arbitrary"; and (3) propriety of a mark , that is, whether it is "scandalous," or "disparaging." Consulting linguists typically write descriptive reports that analyze the linguistic facts underlying the issues of particular cases – sometimes in rebuttal to other linguists' reports. Often, linguists are also called upon to give sworn testimony based upon the reports they have prepared.


This project aims to remotely monitor the patient's electrolyte level and control the online drag system. The IoT project helps caregivers monitor blood sugar levels and fluid flow. Therefore, the patient can be monitored in real time without the need for regular visits from a doctor or supervisor. Many portable devices are manufactured to perform monitoring and tracing functions within the parameters of a patient's body. These include, pulse rate, oxygen meters. The program involves a few steps such as hearing and learning the circuit, processing and transmitting signals, and finally connecting to the network to present the results. In addition, audio reading will be presented via the server. The challenging part was to build our product at a lower cost so that it could work across the hospital especially the public hospital. We found it difficult to measure the loading cell to achieve its accuracy. This app is able to notify local hospitals of a patient / person who needs help. One should be able to send SMS to relatives in an emergency.


This report supplies data for comparing the energy consumption of various modes for the transport of goods and passengers. Public transport and freight transport are studied in turn, and future transport modes are mentioned. Trends over the last few years are discussed. (TRRL)


Introduction: Solid pseudopapillary neoplasm of the pancreas is an uncommon pancreatic neoplasm with malignant potential. There are many unique differences between children and adults in solid pseudopapillary neoplasm of the pancreas. Our study aimed to illustrate the clinical and pathological features of solid pseudopapillary neoplasm of the pancreas in children. Method: The clinical and pathological data of 16 pediatric cases of solid pseudopapillary neoplasm of the pancreas were retrieved and reviewed from the medical records in the Kunming Children's Hospital. Results: There were 11 girls and 5 boys, the sex ratio was 2.2:1 (female-to-male); the median age was 9.5 years, and the average age was 9.56±3.65 years (ranging from 3 to 15 years). The chief complaint was abdominal pain (8/16) and a mass in the abdomen (3/16). The median size of the tumors was 7.9 cm in maximum diameter (ranging from 2.8 to 16.4 cm). The lesions were located at the head (7 cases, 43.75%), the body (4 cases, 25%), the tail (1 case, 6.25%), both the head and the body (1 cases, 6.25%), and both the body and the tail (3 cases, 18.75%). 9 cases (including 4 boys) of solid pseudopapillary neoplasm of the pancreas were cystic and solid (56.25%), 6 cases were purely solid (37.5%), and only 1 case was purely cystic (6.25%). Distal pancreatectomy was the choice for the body/tail tumors (50%), pancreaticoduodenectomy and total mass excision for the head tumors (43.75%), and total pancreatectomy for the head and body tumors (6.25%). Histologically, pseudopapillaes, solid cell sheets surrounded by fibrovascular stroma, nuclear grooves, areas of myxoid change and haemorrhage were the rudimentary histological patterns of solid pseudopapillary neoplasm of the pancreas. On immunohistochemistry the tumors variably expressed vimentin, neuron-specific enolase, alpha-1-antitrypsin, progesterone receptor, β-catenin, CD99 (dot-like intracytoplasmatic), cytokeratin, synaptophysin, Ki-67 (2-4%), and were negative to chromogranin A. The prognosis was satisfying. The average follow-up was 22.88±16.69 months (ranging from 3 to 61 months) and all the patients were event-free after operation. Conclusion: Solid pseudopapillary neoplasm of the pancreas was a borderline tumor with malignant potential and was uncommon in children. Compared with the adults, the pediatric patients showed many different characteristics: gender disparity, main clinical manifestations, the tumor location distribution, the size and configuration, and degenerative changes. Immunohistochemical markers such as β-catenin and CD99 were useful for the diagnosis. Although with malignant potential, metastases and recurrence were rarely observed in children.


The Christian church has a long tradition of biblical interpretation. In the first eight hundred years of Christian history the fathers of the faith produced a nearly inexhaustible library of commentaries and homilies on the Bible. The Church's Bible series seeks to recover this largely lost source of profound theology and spiritual wisdom for today's church. In The Song of Songs, the inaugural volume of this extraordinary new commentary series, Richard A. Norris Jr. uses commentary and sermons written during the first six centuries and in the Latin Middle Ages to illustrate the original Christian reading of Solomon's beautiful love poem. In recent times, the Song of Songs has been more a focus of literary than of religious interest, but Norris's work shows that for early Christians, this poem was counted, with the Psalms and the Gospels, among those scriptures that touched most deeply on the believer's relation to God. In a concise manner Norris selects passages from representative early Christian interpreters, translates them into idiomatic English, and arranges them as verse-by-verse comments on the biblical text itself. The Christian voices gathered here include Origen, Gregory the Great, Gregory of Nyssa, Bernard of Clairvaux, Ambrose of Milan, William of St. Thierry, Bede the Venerable, Augustine of Hippo, Cyril of Alexandria, and many more. Together their stirring reflections on the Song of Songs aptly acquaint contemporary readers with the church's traditional way of discerning in this text a guide to the character of Christian belief and life. Amid the many commentary series available today, The Church's Bible is both unique and original. It will soon become a standard reference work on Holy Scripture. Series: The Church's Bible Series Editors: Robert Louis Wilken (general editor) The Church's Bible presents Scripture as it was understood during the first millennium of Christian history. Compiled, translated, and edited by leading scholars, these volumes return to early and medieval commentaries on key books of the Bible, recovering anew the church's rich classical tradition of scriptural interpretation for clergy, teachers, and all serious readers of the Bible. Titles in this Series: The Song of Songs: Interpreted by Early Christian and Medieval Commentators


Phenolic compounds are considered to be responsible for both the resistance to oxidation and the organoleptic properties of olive oil and their content is a function of various factors including the extracting technology adopted. With the aim of producing virgin olive oils with a good content of total phenolic compounds an experimental research was carried out to evaluate the effect of both the ripening degree of drupes and the temperature reached during their crushing. Routine analyses in force of EC Regulation n. 2568/91 were carried out together with the determination of phenolic compounds by HPLC and the evaluation, by Rancimat method, of the resistance to the oxidation. The results obtained on Coratina cultivar olives showed that it should be more convenient to delay harvesting of olives that usually give bitter-pungent oils to produce oils with an unquestionable quality from both a chemical and organoleptic point of view, that better might fulfil the consumer's expectations, above all in case of immediate marketing.


In this paper, an offline optimal trajectory planning of 6-axis industrial subjected to both kinematic and dynamic constraints has been presented. The positional accuracy of the robot end effector and smoothness of the robot travel can be achieved by minimizing the torque rate and joint jerks. But this results in vast increase in total travel time of robot which as a result affects the productivity. This leads to a formulation of a multi-objective optimization, as jerk and torque rate functions are contradictory to time interval function. Therefore, a new and efficient Hybrid Multi-Objective Evolutionary Algorithm (HMOEA) i.e. Non-Dominated Sorting Genetic Algorithm (NSGA-II) combined with Nelder-Mead simplex method with better local search has been proposed to obtain an optimal Pareto front consisting of non-dominated solutions that can give best trade-off between the objectives. Finally, the optimal results have been validated through simulation and experiment using Kawasaki RS06L 6-axis robot available in product development laboratory of department.


Parmenides'being,as linguistic link verb as well as ontological existence,the 5 features of being in his fragments must be understand logically.Deffering from matter and spirit,which are predicated objects,being is the noun form of link verb.Being as existence is based on rationality,which gives being logical certainty and clarity,language describes objects as well as formulates objects.However,philosophy cannot be replaced by logic because philosophy always seeks for the exiatence behind language.Heidegger takes it as degeneration from Sein to Seiende,that the process from Parmenides' being to Aristotle's ousia.


Background: Second wave of coronavirus disease 2019 (Covid-19) pandemic has been particularly devastating in India. COVID-19 and mucormycosis (also known as black fungus) are causing comorbid conditions to worsen the extent of infection and mortality rates especially in India. Mucormycosis can involve nose, sinuses, orbit, central nervous system, lung (pulmonary), gastrointestinal tract any many other organs, but rhino orbital cerebral mucormycosis is the most common variety seen. Rapidity of dissemination of mucormycosis is an extraordinary phenomenon and a delay in the diagnosis could be fatal.
Aims and Objectives: The objective of this study is to document the clinical features, radiological extent, risk factors, management,and outcome of mucormycosis.
Materials and Methods: The study was retrospective observational study. Eighty-two mucormycosis patients admitted in SGMH Rewa were selected as study subjects. Data regarding clinical features, radiological extent, associated risk factors, comorbidities, management during hospital stay, and outcome of mucormycosis patients were collected on excel sheet and analyzed using appropriate statistical tests.
Results: In our study, majority of the patients were unvaccinated (88%). Most common presenting complaint was nasal congestion with or without discharge in 78% patients followed by Facial swelling, visual disturbances, facial weakness, dental pain, etc. On CT or magnetic resonance imaging examination, all cases of mucormycosis had maxillary sinus (100%) involvement, followed by ethmoid (82%) and sphenoid (78%) sinuses. Diabetes mellitus was most common comorbidity seen in 52% cases. About 83% cases had history of receiving high dose steroid intravenously during management of COVID illness. Among study cases 72% patients have taken oxygen supplementation for more than 72 h, for COVID-19 pneumonia before hospitalization for mucormycosis. Therapy of Liposomal Amphotericin B and Oral Triazole (predominantly oral Posaconazole) was the most common medical treatment offered to all patients with COVID associated mucorpatient. Functional endoscopic sinus surgery was done on 93% cases followed by Modified Denker's procedure was done in 12% cases.
Conclusion: In our study, mucormycosis appears to be associated with COVID-19, diabetes, and use of corticosteroids. Full vaccination with COVID-19 vaccines, judicious use of corticosteroids in patients with COVID-19 and strict control of blood glucose level along with timely and proper management is highly recommended to reduce the incidence of fatal mucormycosis.