Forkhead factors are important regulators of animal development and homeostasis. They are among the earliest to bind quiescent genes, which they activate in conjunction with other transcription factors. Many liver-specific genes are under the control of FoxA2, a liver-enriched forkhead protein. Here we confirmed by chromatin immunoprecipitation that FoxA2 is one of the factors bound to the promoter-proximal enhancer of the gene encoding apolipoprotein AI (a component of high density lipoprotein) and that it functions in synergy with the nuclear receptor hepatocyte nuclear factor-4α. Furthermore, toward identifying additional cofactors that could potentially regulate FoxA2 activity, we identified DNA-de pend ent protein kinase (DNA-PK) as a FoxA2-associated factor upon affinity purification of epitope-tagged FoxA2. We show that FoxA2, found to be a phosphoprotein in vivo, is also an efficient substrate for DNA-PK, which targets serine 283. This residue is contained within a conserved serine-glutamine phos pho ryl a tion signal for DNA-PK, located within the C-terminal third of the polypeptide, just distal to its winged-helix DNA binding domain. We establish that this residue is critical for FoxA2 function because FoxA2 bearing a mutation at this site is severely compromised in its ability to activate a reporter gene under the control of its cognate DNA-binding site (apoAI site B). Complementary experiments rule out that this mutation compromises the ability of FoxA2 to either translocate to the nucleus or to bind site B. We therefore conclude that DNA-PK-de pend ent phos pho ryl a tion of FoxA2 plays a critical role in its transcriptional activation function per se.


Test blocks were established in an improved 27 year old pecan orchard on a 35 × 35 ft spacing near College Station, TX, in Burleson, Co. in Apr. Each block consisted of 4 trees in the row. Pretreatment monitoring of pecan nut development, weather and oviposition were used to time treatment application. Treatments were applied on May 15 after a few eggs had been found by treating each 4 tree block and leaving the adjacent rows untreated. Evaluations were made on Jun 8 by examining 50 nut clusters on each of the 2 middle trees in each block for damage to pecan nuts by the pecan nut cosebearer. All chemicals were applied with a 500 gallon capacity speed sprayer as a dilute solution sprayed on the foliage to the point of runoff. No phytotoxiciry to foliage or nuts was observed from any treatment. Phosalone was the treatment standard.


The resources for agricultural and natural resources research have declined in Zambia. Therefore, there is
a need to generate evidence on the rate of return (ROR) on past investments in sorghum research.
Zambia's sorghum research programme has released seven widely adapted varieties and management
practices. The objective of this study is to assess the socio-economic impact of sorghumresearch in
Zambia from 1983 to 2010 and to assist in identifying priority areas for future research. A multistage
sampling procedure was used in the study and a total of 278 farmers comprising 241 small-scale, 25
medium-scale and 12 commercial farmers was interviewed. A surplus approach was used to estimate the
ROR to research and development investment. The Akino-Hayami and simple benefit-cost analysis
techniques were used to estimate the ROR to investment. The estimated adoption rate in the sorghum
producing sector in Zambia was 33.5%. Farmers identified early maturity, drought tolerance and high yield
as the most important attributes of improved varieties. About half of the respondents cited a lack of
improved seed and information as reasons for non-adoption. The estimated ROR for investment in sorghum
research and complementary services ranged from 12% to 19%, depending on the future adoption path.


Three dogs presented with refractory immune-mediated thrombocytopenia (IMT). All patients failed to respond to prednisone, which is considered a mainstay of immunosuppressive therapy. Vincristine-loaded platelets (VLPs), which act selectively on mononuclear phagocytes,were introduced. After the VLPs were transfused, two dogs responded quickly withimproved clinical signs while the third dogwith recurrent IMT was euthanized due to its deteriorating condition. This case report describesthe efficacy of VLP therapy in refractory IMT patients.


Take new power plants as the example,fire auditing program of the new construction for waste incineration power plant was analyzed.By the combination of the characteristics of the functional architecture,specific building fire control equipment,the fire water supply and other aspects of the optimization fire program were proposed so as to realize the feasibility of water mist fire suppression systems in use.


школь-Abstract. The article studies the effectiveness of complex neuropsychological rehabilitative impact on the nonverbal and verbal higher mental functions (HMFs) in junior schoolchildren with mild intellectual disability (ID) in com-parison with the impact exclusively on the verbal HMFs in the same category of children. Neuropsychological rehabilitation of HMFs was carried out according to the program developed by M.V. Ev-lampieva, T.N. Lanina and M.V. Che-renkov for children 5-10 years of age (2007). The improvement of scale indicators according to the method of "Neu-ropsychological diagnostics of school-age children" suggested by J.M. Gloz-man and A.E. Soboleva (2014) was used as performance criteria. The interrelation between nonverbal and verbal HMFs in junior schoolchildren with mild ID "be-fore" and "after" neuropsychological rehabilitation was studied for the first was also evaluated. The analysis of the data obtained has convincingly proved the effectiveness of the complex ap-proach to rehabilitation of the HMFs. The children of the 1st group (complex HMF rehabilitation) demonstrated higher neuropsychological indicators and stronger connections between the HMFs when compared to the 2nd group (only verbal HMF rehabilitation). In junior schoolchildren with mild ID, all HMFs are impaired to a greater or lesser de-gree. It has turned out that isolated in-tervention involving only verbal HMFs in this category of children is saliently insufficient and ineffective.


As the Application Specific Integrated Circiut(ASIC) design size increases, the chip verification is one of the most important phases. Transaction-based verification method using SystemC was introduced and analyzed. A concrete chip design was verified with this verificaton method and other traditonal verification methods. The test results show that transaction-based verification can get better effect and higher efficiency.


Calciphylaxis, also known as calcific uremic arteriolopathy (CUA), affects small arteries of the skin in patients with end-stage renal failure, dialysis patients, and patients with hypercalcemia. The condition is characterized by the calcification of small blood vessels leading to skin necrosis without inflammation. It is frequently complicated by superimposed infection and bleeding and has a high mortality rate.
The rare condition is yet to be documented on the islands of Saint Vincent and the Grenadines. The authors have, therefore, made efforts to document, educate, and discuss this rare presentation in a 65-year-old local Vincentian male with 30 years history of poorly controlled diabetes mellitus and hypertension who commenced hemodialysis two years prior to the presentation for end-stage chronic renal failure. With the increasing incidence and prevalence of diabetes mellitus, hypertension, and complications of chronic kidney disease, and renal failure, this article is written as a case study with a concise literature review on calciphylaxis to provide continuing medical education and increase the level of awareness among medical students and index of suspicion among healthcare providers.


Abstract N,N-Dimethyl-C-phenylglycinemethylester reacts with Pd(OAc)2 in acetic acid to give the orthopalladated, acetato bridged complex 1. Treatment of 1 with sodium halide affords the chloro, bromo, and iodo bridged compounds [Me2NC(H)(CO2Me)C6H4PdX]2 (2a -c) (X = halide). From 2a and 1,1′-bis(diphenylphosphino)ferrocene the phosphine bridged trinuclear complex 3 is obtained. Substitution of the amine ligand of 2a by the phosphino group is observed for the reaction of 2a with Ph2PC(Me)C(Me)PPh2. Insertion of 2,6-dimethyl-phenylisocyanide, CO, alkyl-vinyl-ketones, and diphenylacetylene into the Pd-C bond o f 2a -c provides the orthosubstituted organic and organometallic derivatives of phenylglycine 6a -c, 7, 8a -b and 9a -c. The crystal structures of 1, 4a, 6a, 7 and 9a were determined by X-ray diffraction.


Introduction .. 624 I. SHASTA COUNTY AND ITS CATrLE INDUSTRY 629 A. Physical Environment 629 B. Social Environment 632 C. Work Environment: Modes of Cattle Ranching ....... 636 1. The traditionalists 637 2. The modernists 638 D. The Benefits and Costs of Boundary Fences 640 II. THE POLITICS OF CATTLE TRESPASS IN THE NORTHEASTERN FOOTHILLS 643 A. Caton's Folly: The Closing of the Range at Round M ountain 644 B. Caton's Repentance: The Defeat of the Oak Run Closure Petition .. 647 1. Frank Ellis 647


The over-all mission of the AmpliFIRE Support Action is to support the FIRE Community to prepare FIRE for 2020, by strengthening the exploitation and impact creation capacities of Future Internet Research and Experimentation (FIRE) facilities. AmpliFIRE vision for year 2020, setting out a transition path from the current situation towards a "FIRE Ecosystem" for 2020


The aim of this study was to assess situations related to overtraining within the context of sport (RESTQ-Sport, Kellmann and Kallus, 2001; Gonzalez-Boto et al., 2008c) and identify its temporal relationship with mood state disturbances (POMS, McNair et al., 1971; Balaguer et al., 1993) and its possible influence on the appearance of imbalances between stress and recovery according to the coping strategies used to deal with stress (ISCCS, Gaudreau and Blondin, 2002; Molinero et al., 2006, 2008, 2009). A total of 167 athletes (62.5% men, and 36.9% women) ranging in age from 18 to 28 years old in 11 sport modalities participated in the study. The results showed that modifications took place during the three measurements made of the levels of general stress ( p = .027*), conflict/ pressure ( p = .000**), fatigue ( p = .000**), general wellbeing ( p = .022*), burnout/ emotional fatigue ( p = .009**), physical fitness/ injuries ( p = .000**), burnout/ personal accomplishment ( p = .000**), self-regulation ( p = .000**), non-sport stress ( p = .006**), sport stress ( p = .001**), sport recovery ( p = .000**), and total stress ( p = .001**), which had changed compared with the main indices assessed by the RESTQ Sport. At the emotional level, we observed changes in the levels of depression ( p = .040*), anger, ( p = .006**), confusion ( p = 036*) and total mood disturbance ( p = .041*). We did not find any changes in the coping strategies used. According to these results, it is necessary to pay more attention to temporal changes during recovery, because they may lead to positive adaptations after overtraining periods and their relationship to athletes' mood states, which have usually been used as fatigue indicators (Gonzalez-Boto et al., 2009; Kell - mann et al., 2001; Rietjens et al., 2005). Athletes use a number of coping strategies that may lead in different ways to the balance between stress and re -


Amyand's hernia, defined as an inguinal hernia with appendix as the content of hernial sac, is a exceedingly rare disease, reported in 1% of cases of inguinal hernia repair. The appendix can be normal or inflamed and acute appendicitis is seen in 0.13% of cases. We hereby report two cases of Amyands hernia which were treated at ESI hospital PGIMSR, Delhi highlighting the fact that rather than simply being an anatomical curiosity, Amyands hernias require individualized attention to decide how to manage both the appendix and the hernia. First case was admitted in emergency as strangulated hernia. Inflamed appendix was noted intraoperatively as hernial content for which appendectomy and herniotomy was done. Our second case was worked up as routine case of right congenital hernia and after seeing the content of hernia sac as appendix, appendix was pushed back and herniotomy was done.


A betweenness is got by probability of faultless work of object and factor of safety in a model "loading-durability" at a priori information about the type of partition of load and durability as distribution of Weibull.


Objective: The In-vitro anti-oxidant and anti-inflammatory capacity of different solvent plant extracts and essential oil of Semecarpus ancardium Linn. F leaves were evaluated by different assay. Method: For In-vitro anti-oxidant activities 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and Iron chelating methods were employed. Ascorbic acid was used as a standard. Anti-inflammatory potency was determined by Heat Induced Hemolytic and Protein Denaturation method using Diclofenac sodium as a standard. Results: The percentage inhibition and stabilization values for anti-oxidant and anti-inflammatory were obtained and discussed. Finally a comparison was made with the commercial available formulation used for pain. Conclusion: The result clearly indicates that the methanolic leaf extract of the study species shows effective in scavenging free radical and can be used as a good anti-oxidizing agent in various fields of medicine, food industry etc. It also shows that the methanolic extracts of leaves are capable against anti-inflammatory activity.


The pandemic currently being experienced by Indonesia and even throughout the world, namely Covid-19, has resulted in an increase in the needs that exist in society. One of them is the need to make ends meet. Many people today make loans to financial institutions. Basically, in carrying out a contract or agreement, there are consumers who must be protected, in accordance with Law Number 8 of 1999. Every consumer must have their rights protected and guarantees regarding consumer protection get enough attention because as consumers they should be protected from various fraudulent transactions given the right to get clear information and of course the right not to discriminate. Contracts originate from differences or differences in interests between the parties, both parties must show an active attitude in order to reach an agreement so that the intended profit can be obtained. The consequences that arise from this condition of default cause an agreement to be canceled and which is null and void. The formulation of the problem in this paper is how legal protection and dispute resolution for consumers against forced vehicle withdrawals by the deb collector. The purpose of this research is to find out how legal protection and dispute resolution can be carried out by consumers in protecting consumers from finance company companies that use debt collector services. This journal research uses normative juridical research methods, by examining legal norms in the legislation, legal theories and jurisprudence related to the issues discussed. This research approach uses a statutory approach (statute approach) and a conceptual approach (conceptual approach). Based on the results of the study, the authors obtained answers to the existing problems, namely, that the forced taking of a motorized vehicle in the financing agreement is that the consumer has committed default, but if the motor vehicle as an object of fiduciary security is not registered by the finance company at the Fiduciary Registration Office, then the forced retrieval is invalid. Then against forced taking that is not in accordance with these applicable provisions, consumers can file objections to the financing company based on mutual agreement in the financing agreement, but if it cannot be resolved, the consumer can report the forced taking based on the article of confiscation as regulated in the Book of Law Criminal Law (KUHP).


Especially useful annulus within the mounting frame (10) to repair the valve shape to achieve adequate bonding. Benwanai hemispherical mounting frame (10) is inserted into the aortic valve annulus, providing a reconstruction of self aortic valve. Benwanai hemispherical mounting frame (10) includes a plurality of bends (12) interconnecting point and (14). Generally, interconnection point (14) is coincident with the shape of the commissure, the bent portion (12) corresponds to the shape of the valve leaflet annular. Bent portion (12) is bent in a first plane and the second plane of the hemispherical mounting frame (10), corresponding to the three-dimensional shape of the leaflets of the aortic valve.


Let n be a positive integer, and C-n(r) be the set of all n×n r-circulant matrices over the Boolean algebra B={0, 1}, G_n=∪[DD(]n-1[]r=0[DD)]C-n(r). For any fixed C in G-n. We can define an operation"*" in G-n as follows: A*B=ACB for any A, B in G-n, where ACB is the usual product of Boolean matrics. Then (G-n, *) is a semigroup which is called the sandwich semigroup of generalized circulant Boolean matrices with sandwich matrix C and denoted by G-n(C). In this paper, the regular elements in G-n(C) are characterized and an algorithm to determine all g-inverses for each regular element in G-n(C) is given.


Azo dyes are an important class of pH indicators, with some applications in novel sensors. In this paper, the authors present a theoretical study to elucidate the effect of physical factors on the halochromic behavior of the azo dyes The studied azo dyes are methyl red and methyl orange and the physical factors such as temperature, pressure, ionic strength of solvent and isotope type of constituent atoms are taken into account. The obtained values for tautomery equilibrium constant show that the azo form of the indicators is more stable than their hydrazone form. Therefore, in the studies related to the acid-base equilibrium of the indicators, only azo form is considered. In the meantime, pH change of color change of the indicators, ∆pH, with the physical factors in the acid-base equilibrium of the indicators is studied. Increased temperature causes pH of color change of indicators to decrease. This drop is approximately similar in various pressures. Increasing pressure at any temperature results the increase of pH of color change. The effect of pressure on ∆pH is lower under higher pressures and is not dependent on the indicator type. By decreasing the polarity of the solvent used, the pH of color change of the indicators increases. The use of isotopes of atoms produces the increase in the pH of color change of the indicator that its value depends on the type of atom and type of the indicator. The methodology in this work will be useful in future dye design and is applicable to other dye classes as well. These findings indicate the importance of physical factors on the halochromic behavior of dyes for further research the development of pH-sensitive sensors. Keyword: DFT, Halochromic, Isotope, Pressure, pH indicator, Solvent, Temperature Copy rights: © This is an Open access article distributed under the terms of International License. Computational Study of the Effect of Physical Factors on the Halochromic Behavior of Azo Indicators Using Density Functional Theory Journal of Computational Chemistry & Molecular Modeling (ISSN: 2473-6260) DOI: 10.25177/JCCMM.3.2.RA.544 Research Farzaneh Zanjanchi et al. ——————————————————————————————————————————————————– WWW.SIFTDESK.ORG 277 Vol-3 Issue-2 SIFT DESK


With the current emphasis on computers in science and engineering, it is felt that the undergraduate of such disciplines should be introduced to the applications of the computer as early in his educational program as feasible. With this premise in mind, an IBM 1620 computer has been put to use in an undergraduate light and optics laboratory course, generally taken by sophomores and/or juniors. Several experiments that are performed in the laboratory, together with their respective computer programs, written for the 1620 in FORTAN II language, are presented.


Today's data centers consist of thousands of servers hosting a variety of cloud-based services. In this paper, a scalable and new technique is presented for traffic engineering in software-defined data center networks helping to design an optimal demand-path mapping with a tolerable computational complexity. The proposed method is based on linear programming model and attempts to minimize the maximum link utilization that causes minimum link congestion. The method focuses on an optimal solution to load balancing in networks. It proposes a new decomposition technique that can limit the search space of the original Linear Programming problem, such that the time required to solve the problem can be reduced substantially. To reduce time complexity, a decomposition technique is used to divide the problem model into smaller sub-problems, which are then solved simultaneously by applying parallelizing techniques (multiple-core computing and OpenMP).Simulation results show that solving time and load balancing are considerably improved. KeywordsData center networks, Software-defined networks, Traffic engineering, Congestion control, Linear programming decomposition, Parallel solution. نف و مرن شنایار یشهوژپ یملع هلجم ا تاعلاطا یرو لباب یناوریشون یتعنص هاگشناد :هلجم هحفص www.jscit.nit.ac.ir دلج 7 هرامش ، 1 لصف ، ناتسبات و راهب 1397 هحفص ، 42 55 رد ی تفا : 28 / 09 / 1396 ، رگنزاب ی : 23 / 04 / 1397 ، ذپ ی شر : 12 / 08 / 1397


The x‐ray pulse‐height analysis (PHA) diagnostic uses a liquid‐nitrogen cooled array of 5 Si(Li) and one HpGe detectors to do time‐resolved (5–100 ms) x‐ray spectroscopy of the central horizontal chord of the Tokamak Fusion Test Reactor (TFTR) plasmas in the 1–50‐keV range. Central electron temperature Te and concentration of medium and low‐Z impurities are derived from the spectra. Remotely selectable absorber‐foil arrays provide selection of the energy range. Fixed and movable aperture arrays allow approximate equalization of count rates in different energy bands and extend dynamic range. Amplifier pulse shapes are approximately triangular. Main amplifier peaking time is 4 μs yielding 230‐eV FWHM at 5.9 keV. Pileup inspection times are selectable at 0.13, 0.4, or 0.9 μs. Throughput is up to 42 kHz. The PHA has been used to study temperature and impurities over a wide range of TFTR operational parameters. Dramatic variations in metal impurities with density, plasma current, and major radius have been obs...


Reed is a kind of high biomass plants.It can be used as important raw material for bio-ethanol production.In this research,several pretreatments(steam explode,alkali-catalyzes steam explosion,acid-catalyzes steam explosion) and enzymatic saccharification procedures were studied.Hydrolystates from three pretreated(dilute acid,sodium hydroxide and acid-catalyzes steam explosion) reed were analyzed.The results showed that acid-catalyzes steam explosion was the best pretreatment in terms of resulting reducing sugar concentration in the hydrolysate after enzymatic hydrolysis.The conditions of acid-catalyzes steam explosion was pretreated by soak in 1.0% dilute acid,then performed steam explosion in a retention time of 120s and a steam-pressure of 2.0MPa.The highest rate of hydrolysis and enzymatic saccharification were 37.8% and 82%,respectively.The analysis of hydrolysate for pretreatment and enzymatic saccharification from reed indicated that acid-catalyzes steam explosion pretreatment could produced more fermentable sugar,and the contents of the glucose and xylose in enzymatic hydrolysate were 52.75% and 43.39%,respectively.


TPS10126Background: Breast and prostate cancer survivors are at an increased risk of developing comorbidities such as metabolic syndrome (MSY), diabetes, and cardiovascular disease exacerbated by c...


A microwave photonic filter based on a structure of an actively mode-locked fiber laser is proposed. The mechanism and relation between the actively mode-locked fiber laser and the proposed microwave photonic filter are theoretically investigated and experimentally demonstrated. A microwave photonic filter with a free spectral range of about 7.1 MHz, a 3-dB bandwidth of about 0.05 MHz (centered around a frequency of 2.5 GHz), and a Q-factor of about 140 is demonstrated. The proposed microwave photonic filter can be tuned easily by adjusting an optical variable delay line in the ring cavity. A good agreement between the measured results and the theoretical estimations is demonstrated.


Laser tissue welding involves the partial denaturing and renaturing of the collagen triple helical structure. Although the mechanisms of laser tissue welding are not well understood, water in tissues plays an important role in the process. High quality welding of human and porcine aorta tissue have been achieved using NIR lasers tuned to the water absorption band around 1450 nm. Fluorescence and Raman spectra from welded and non-welded regions are compared for ex vivo human and porcine aorta tissues. The fluorescence from the outer surface of welded aorta was substantially weaker than the fluorescence from the non-welded region. The Raman spectra from the welded and non-welded tissue regions appeared similar in the energies of the observed vibrational levels but the intensity of the fluorescence wing was considerably greater from the outer surface of the welded region as compared to the non-welded region. For the outer surface of the aorta, the emission intensity from the welded region was larger than for the non-welded region.


Astronomers are used to seeing strange things when they turn their telescopes toward the Red Planet—some of them tantalizingly, and often deceptively, Earthlike. The image above, a stereographic projection centered on Mars's north pole, was returned by the Hubble Space Telescope Wide‐Field Planetary Camera 2 on 27 April. It depicts a "spiral storm" 1600 km in diameter (the storm is a diffuse white spiral to the left of the bright ice cap) just south of the planet's northern polar ice cap. Although such Storms were first observed over 20 years ago, April's tempest was three to four times the size of previously observed storms. So far detected only in Mars's northern hemisphere during its summer, the storms bear some resemblance to terrestrial polar cyclones.


Abstract: Because of a desire to provide the most suitable treatment for hemodialysis patients, psychological, physical and social problems influencing psychiatric conditions of the patients were studied. One hundred hemodialysis inpatients were compared in each group divided by their characteristics, i.e. age, presence of family problems, occupation, physical complications and their character traits.


We report a 63-year-old patient with diabetes mellitus and end-stage renal disease on hemodialysis who was admitted for fever. A transthoracic echocardiogram revealed a large vegetation on the mitral valve. Blood cultures yielded "Acinetobacter baumannii". Right parietal hemorrhage developed on the fourth hospital day. This is probably the first reported case of "Acinetobacter" endocarditis with cerebral embolism in a chronic hemodialysis patient.


A graphene-silicon conductive photodetector is designed and demonstrated with ultra-high responsivity (~107A/W) by introducing a graphene-sheet with a geometrical size designed optimally.


Two-state Markov chain models of different orders have been used to simulate the pattern of rainfall during the monsoon season (June-September) over Gangetic West Bengal (India). The analysis is based on the relevant data for 31-year period (1970-2000) for four major meteorological stations in the region. The determination of the proper order of the Markov chain that best describes the rainfall pattern is an interesting problem and Bayesian information criterion has been used for the purpose. Bayesian information criterion (BIC) reveals that third order Markov chain model best describes the rainfall pattern in general except for one station. This is verified and it is found that third/fourth order chain simulates the observed data more closely than the chains of other orders using the classical goodness of fit test. The time independent behaviour of the chain has also been studied with the help of steady state probabilities. The theoretical and observed values of the mean recurrence time have been found to be in close agreement.


The present invention discloses an electrolytic water purifier, in which three different electrolytic water obtained, regardless of how the quality of the raw water enters through the electrolytic water twice to remove all types of diseases induced by reactive oxygen species can be obtained that they contain large amounts of active hydrogen mild alkaline water.


The book examines the role of CLIL within the context of the Kurdistan Educational System. It investigates CLIL implementation in Kurdistan's schools and its impact on the acquisition of the English language, contents of main subjects, and the whole educational system. It first reviews the existing theoretical viewpoints on CLIL and its significance in language learning through the study of content of other subjects. A framework is then developed to describe the current situation of the Kurdistan Educational System and review CLIL in a different context. Data suggests that studying the content of some of the main subjects in Kurdistan's schools provides more opportunity to expand intellectual horizons of students while improving their English language skills. Therefore, integrating learning language and content from early age in schools will impact the entire education and higher education systems. This is the first study to investigate the role of CLIL in the Kurdish context and further longitudinal studies are required to improve our understanding of the implications of the wider role and advantages of implementing CLIL and how to incorporate CLIL into Kurdish education policy.


With the onset of globalisation, where economics and markets play a dominant role in organisational sustainability, no individual organisation can guarantee success based on its own efforts alone. Over the years, the role of those, running an organisation, has undergone a major change-from dependence to independence and now interdependence. The era of interdependence-where teamwork and group dynamics can make or break the business-becomes a necessity and the accepted way of doing things. But with the entry of educated rational managers, freedom of thought and expression; the managers are encouraged to think independently bringing about a higher degree of initiative and quicker decisionmaking. Although there are flashes of brilliance from star performers, the organisation's collective performance is often disappointing and less spectacular. Participation is vital in the viability and survival of an organisation. Motivated and empowered employees are crucial in achieving and meeting organisational goal. Quality products or services are attained when people in an organisation work in tandem aligning their personal goals to the organisational goals and are ready to take the extra step towards achieving excellence. When employees put their hands, heads- and most importantly their hearts in their respective jobs, they produce even astounding results in quality and quantity, productivity and profitability. Every member of an organisation is a store-house of ideas, an uncut diamond and an untapped reservoir of talent that, when properly harnessed, can bring enormous results. Developing quality consciousness in the interest of the organisation among people is like planting trees. It takes a lot of patience but the fruits are very satisfying at the end. In this context, this paper is an endeavour to have a conceptual and theoretical framework to focus on all such possible areas of human resource productivity, being responsible towards achieving organisational excellence. Basically, in this paper, an attempt is theoretically made to visualise different parameters of employee participation in an organisational functioning and how it leads towards achieving organisational success.


The most famous sentence of al-Hallaj (244/858–309/922), "I am the Truth" (ana-l-Haqq) always produced a plenty of interpretations and was a basis of accusations to this Sufi. With a few exceptions most of Muslim fuqaha and historians criticized this sen tence of al-Hallaj. The paper analyzes traditions related to this sentence and its interpretation in subsequent Sufi tradition.


Time series forecasting models based on a linear relationship model show great performance. However, these models cannot handle the the data that are incomplete, imprecise, and ambiguous as the interval-based fuzzy time series models since the process of fuzzification is abandoned. This article proposes a novel fuzzy time series forecasting model based on multiple linear regression and time series clustering for forecasting market prices. The proposed model employs a preprocessing to transform the set of fuzzy high-order time series into a set of high-order time series, with synthetic minority oversampling technique. After that, a high-order time series clustering algorithm based on the multiple linear regression model is proposed to cluster dataset of fuzzy time series and to build the linear regression model for each cluster. Then, we make forecasting by calculating the weighted sum of linear regression models' results. Also, a learning algorithm is proposed to train the whole model, which applies artificial neural network to learn the weights of linear models. The interval-based fuzzification ensures the capability to deal with the uncertainties, and linear model and artificial neural network enable the proposed model to learn both of linear and nonlinear characteristics. The experiment results show that the proposed model improves the average forecasting accuracy rate and is more suitable for dealing with these uncertainties.


Objective: To develop and validate a simple, selective, rapid, precise, and accurate high performance liquid chromatographic (HPLC) method for determination of atorvastatin in bulk and its pharmaceutical formulation product. Method: Reversed phase-HPLC (RP-HPLC) method was performed by a mobile phase consisting mixture of methanol and ammonium acetate buffer (pH 4.5) in the proportion 60:40 v/v. A ZORBAX Eclipse plus C (4.6 mm × 100 mm, 3.5 μ) column was used as a stationary phase. HPLC analysis of atorvastatin was carried out at a wavelength of 241 nm with a flow rate of 1 ml/minute. 18 Results: The linear regression analysis data for the calibration curve showed a good linear relationship with a correlation coefficient 0.9984. The linear regression equation was y=3726540.2x+27390388.1. This was found to give a sharp peak of atorvastatin at a retention time of 2.77 minutes. Validation parameters were evaluated for the method according to the ICH (Q2R1) guidelines. The limit of detection and limit of quantification for the method were 0.6721 μg/mL and 1.9989 μg/mL, respectively. The % relative standard deviation values for intra-day precision and inter-day precision were found to be 0.31% and 0.30%, respectively. An accuracy of the method was determined through recovery studies which were found to be within 97.57-102.22%. Conclusion: The method was validated for system suitability, accuracy, precision, robustness, and ruggedness. The precision, accuracy, sensitivityshort retention time and composition of the mobile phase indicated that this method is better than the earlier methods developed for the quantification of atorvastatin. Keywords: Atorvastatin, Reversed phase-high performance liquid chromatographic method development, Validation.


Pulmonary dialysis is a new concept and a good alternative to conventional mechanical ventilation of lung. Details of this concept have been reported in a book "The concept and design of intra-vascular access based mechanical ventilation of lung", published in 2020. On the basis of "The theory of relative stability" in 2016, an upgraded version of mechanical organ support can be developed. Here in this article, design and diagram of a newly proposed ventilator system, is going to be reported for pulmonary support, which is equally effective even in complete dysfunction of lungs. Therefore, the situation of planned "artificial lung de-functioning" can be achieved for therapeutic purpose. Moreover, it is a triumph over the conventional mechanical ventilation and organ support in ICU. In addition to this, artificial organ support for other organs (renal, hepatic etc.) can be also developed eventually. Moreover, any component or element in body fluid can be dialyzed based on this principle (component dialysis). Beginning of a new era is the effect.


The invention belongs to video encoding technology, in particular to an interframe fractional order movement searching method of H.264. The invention solves the technical problem that a selection method of a macro partition mode can rapidly partition a macro block in the movement searching. The selection method of the macro partition mode in the movement searching uses a threshold valve to judge SAD value of a partitioned block, thus judging matching degree of a block in the current mode; if the partitioned block has higher matching degree in the current mode, other modal partitions are not carried out on the partitioned block so as to reduce quantity of selection of the macro block partition mode; if the partitioned block has lower matching degree in the current mode, other modal partitions are carried out on the partitioned blocked so as to guarantee interframe precision of prediction. The invention can effectively reduce quantity of selection of the macro block partition selection mode and movement searching times of the block, thus improving arithmetic speed of an encoder.


This paper presents a novel parallel-pipelined architecture for the computation of real valued fast Fourier transform (RFFT). The proposed architecture takes advantage of the redundancy of some computations with respect to complex FFT along with low multiplicative complexity of the radix-22 architecture. Folding transformation is used to derive a novel parallel-pipelined architecture by exploiting the redundancy in the modified flow graph. The proposed parallel architecture requires log4N − 1 complex multipliers and N − 1 complex delay elements.


Presented the problem of modeling of the interaction of information flow in medical software-hardware systems. As a means of describing such systems is proposed to use the Petri net (PN), which combines the properties of certain interpretations and modifications PN. A classification of Petri nets, a combination of properties of PN to describe medical systems with heterogeneous components. A comparison of models of medical management system, built using UML-diagrams and PN-network, highlighted in benefits.


Over the last decade, various studies have linked pomegranate (Punica granatum Linn), a fruit native to the South East of India, with Mellitus diabetes prevention and treatment. This article focuses on current laboratory and research related to the effects of pomegranate extractions (peels, flowers, and seeds) and some of their active components on biochemical and metabolic variables associated with the pathology observation of Mellitus diabetes. This review systematically presents findings from cell culture and animal studies as well as clinical human research. One key mechanism by which pomegranate fractions affect the Mellitus diabetic condition is by reducing oxidative stress and lipid peroxidation. This reduction may occur by directly neutralizing the generated reactive free radicals, oxygen species, increase in certain antioxidant enzyme activities. Fasting blood glucose levels were decreased significantly by punicic acid, methanolic seed extract, and pomegranate peel extract.


A phenomenological model of the selective flocculation of coals by synthetic latexes was analyzed theoretically. The laws of wetting of various grades of coals by industrial samples of latexes were studied. The efficiency of adhesion interaction of coal and latex grows with an increase in the content of the butadiene fragment in the polymer chains. The conclusion was made on the influence of the intrinsic ionogenic groups of the latexes on their flocculating ability. The maximum strength of the coal-latex complexes is achieved on medium-rank coals.


concepts. Even though a large number of studies about the internet or cyberspace have been compiled, it can still be asserted that little is known about how cyberspace is structured and how it operates. Therefore, this chapter takes as its premise that there is a need to define and illustrate the features of cyberspace inherent across the government, civil society, and military sectors, which should begin with an examination of the nature of cyberspace to establish how its features may shape it into a potential battleground. 2.1 The nature of cyberspace Although the term 'cyberspace' originally came from science fiction, for many of us cyberspace now forms part of our everyday routine. Since 1990, rather than considering cyberspace to be a manifestation of a video game, academia has begun to take cyberspace more seriously. This development is certainly closely related to the rapid commercialisation of the internet in the 1990s. Michael Benedikt (1991:122) defined cyberspace as a structure formed by an amalgamation of computer technologies such as both 2D and 3D graphic user interfaces, internet technology, virtual reality, multimedia, databases, and hyperlinks. He also ascribes a broad domain of physical space to the nature of the computer-sustained virtual world. Along with the technical development of computers and the internet, cyberspace seems to be becoming more concrete and the concept of cyberspace is continuously expanding. Cyberspace is not only a physical body of machines or 16 Michel Benedikt also indicates that cyberspace is 'a new universe; a parallel universe created and sustained by the world's computers and communication lines. A world in which the global traffic of knowledge, secrets, measurements, indicators, entertainments, and alt-human agency takes on form: sights, sounds, presences never seen on the surface of the earth blossoming in a vast electronic night.' (Benedikt, 1991:1)


Land cover data are required to parameterize watersheds for hydrological modeling. There is a multitude of different land cover maps, and determining which input map for the model can be unclear. The objective of this study is to quantify the differences between various publically available land cover maps to determine their relative suitability for hydrological modeling of the Yampa River Basin in northern Colorado. The land cover maps compared in this study are derived from Advanced Very High Resolution Radiometer (AVHRR), Landsat Thematic Mapper (TM), and Moderate Resolution Imaging Spectroradiometer (MODIS) imagery. These maps are compared to a 30-m land cover map modeled from ground data and remote sensing imagery collected in 2004, and will be used to rank publicly available TM, AVHRR and MODIS land cover maps. In order to compare the different land cover products, all data must be resampled to a common spatial resolution and reclassified to a common species resolution. Once this is accomplished, the maps are compared on 4 levels. The 4 comparisons are based on: (i) total aggregated land class percentages; (ii) pixel accuracy; (iii) scene accuracy; and (iv) cumulative streamflow model output from the US Geological Survey Precipitation-Runoff Modeling System (PRMS) in relation to observed cumulative streamflow. The results will determine the best input land cover data for modeling streamflow in the Yampa River Basin, and provide information about the required spatial, spectral, and classification resolution of these maps to optimize results for streamflow modeling.


A wafer inspection apparatus is provided to prevent particles from dropping on a wafer surface by changing a flow of gas to be supplied to convert an interior of a vacuum chamber into a vent state. A wafer inspection apparatus includes a first cover(130) protecting a wafer and forming an outer shape of a chamber, a gas supply line(110) connected to an upper portion of the first cover and serving as a flow pass of gas, and a second cover(150) formed in the first cover for guiding flow of the gas supplied through the gas supply line. The gas supplied from the gas supply line moves along an upper surface of the second cover to an edge of the wafer.


The study examined principals' curricular and school-community relations instrumentalities for sustaining peaceful learning environments in secondary schools in Bayelsa State of Nigeria. Two (2) research questions and 2 hypotheses were answered and tested in the study, respectively. The design of the study was the analytic descriptive survey, with the population as all the 188 public secondary schools in Bayelsa State of Nigeria. These schools have a staff strength of 4579 (3872-teaching and 707non teaching, from which 371 (321-teaching and 50-non teaching) were selected as sample, using the purposive and stratified random sampling technique. The instrument of the study was a researchers' constructed and validated 14-item scale titled Principals' Curricular and School Community Relations Instrumentalities for Sustaining Peaceful Learning Environments Scale (PCSCRISPLES), with a reliability index of 0.74, obtained using the Cronbach Alpha model. Mean and standard deviation were used in answering the research questions while t-test was used in testing the hypotheses at 0.05 level of significance. The results of the study show that principals curricular and school-community relations instrumentalities sustain peaceful learning environments in secondary schools in Bayelsa State of Nigeria. Consequently, it was concluded that curricular and school-community relations instrumentalities of principals contribute immensely to sustaining peaceful learning environments in schools. Therefore, it was recommended that stakeholders in school governance should continue to utilize existing curricular and school-community relations instrumentalities in maintaining peace in school systems while also looking out for more proactive curricular and external relations laden


In this study several algorithms for the generation of inexpensive and fault-tolerant graphs are evaluated with respect to the quality of the found graphs and to the runtime requirements. A special focus lies on the properties of the algorithm that basically is a simulation of the foraging of the slime mold Physarum polycephalum, since in many other works the deployment of this algorithm does not go beyond the conclusion, that the algorithm is capable to generate a graph, while quality of the graph and runtime requirements of the algorithm are not reported. Our results show that the slime mold algorithm has some interesting features, however it is not the best means to construct highly efficient graphs out of large sets of nodes.


Monitoring Internet traffic is critical in order to acquire a good understanding of threats and in designing efficient security systems. It is the most important issue to monitor the traffic in internet and also in designing efficient security systems. Honeypot is one of the security tools for gathering intelligence of Internet attacks, traffic collected by honeypot is of high dimensionality that makes it difficult to characterize. In this paper, a multivariate analysis technique, for characterizing honeypot traffic and separating latent groups of activities is used. A multivariate analysis consists of collection of methods that can be used for detecting unauthorized malware over the internet. Data visualization, Data mining and statistical techniques are the multivariate analysis techniques for characterizing Honeypot. The internet has become a platform for all kinds of security-sensitive services and applications. In this modern era of computing, internet plays an important role and therefore, securing network hosts, learning attack methods, capturing of attack tools, and studying motives of computer criminals are important tasks for network administrators and security engineers. One important aspect of network attacks is malicious software (malware) that spreads autonomously over the network by exploiting known or unknown vulnerabilities. The various elements like web browsers, e-mail client and office are absolutely not secure with the development of new client application software vulnerabilities. This paper highlights the development strategy towards intrusion detection system based on honeypot. It is a trap set to detect, deflect towards any unauthorized/ anonymous malware distributed globally over the networks. We achieved designing a prototype with a unique network crawler which will keep track the illegal software but it has also potential to track the source URL from which the malicious events are taking place at the client side. KeywordHoneypot, VMware, diagnose, threadpool , FAIR


In today's 60GHz radios large signal to noise ratios are needed due to the high atmospheric losses inherent to 60GHz communications. This paper tackles the isolation of leakage noise from the transmitter to the receiver by means of a reactive surface. We achieved the aforementioned by using a variation of the Artificial Magnetic Conductor (AMC) on a one layer Liquid Crystal Polymer (LCP) substrate. It is proven that in order to achieve noise suppression the artificial material does not require a high-impedance surface.


Extrusion of a polytetrafluoroethylene (PTFE) pilot seal located in the Space Shuttle Orbiter Primary Reaction Control Subsystem (PRCS) thruster fuel valve has been implicated in 68 ground and on-orbit fuel valve failures. A rash of six extrusion-related in-flight anomalies over a six-mission span from December 2001 to October 2002 led to heightened activity at various NASA centers, and the formation of a multidisciplinary team to solve the problem. Empirical and theoretical approaches were used. For example, thermomechanical analysis (TMA) and exposure tests showed that some extrusion is produced by thermal cycling; however, a review of thruster service histories did not reveal a strong link between thermal cycling and extrusion. Calculations showed that the amount of observed extrusion often exceeded the amount allowed by thermally-induced stress relief. Failure analysis of failed hardware also revealed the presence of fuel-oxidizer reaction product (FORP) inside the fuel valve pilot seal cavity, and differential scanning calorimetry (DSC) showed that the FORP was intimately associated with the pilot seal material. Component-level exposure tests showed that FORP of similar composition could be produced by adjacent oxidizer valve leakage in the absence of thruster firing. Specific gravity data showed that extruded fuel valve pilot seals were less dense than new pilot seals or oxidizer valve pilot seals, indicating permanent modification of the PTFE occurred during service. It is concluded that some thermally-induced extrusion is unavoidable; however, oxidizer leakage-induced extrusion is mostly avoidable and can be mitigated. Several engineering level mitigation strategies are discussed.


In this paper, a numerical homogenization approach is proposed to obtain isotropic Biot's parameters based on the microstructure of an porous material. It is assumed that a macroscopic point can be ...


Technogenic geochemical anomaly was formed as a result of large-scale copper-smelting production run for almost hundred years without any ecological standards in Karabash region. Environmental assessment of the area affected by the Cu smelter plant after the plant's substantial modernization shows that atmospheric emissions remain sufficiently high, and re-vegetation that began emerging during the time the plant was closed has slowed down after the plant reopened. The assessment of contamination of soil, bottom sediments and surface water showed extremely high concentrations of heavy metals.


Combining a crossed molecular beam with mass spectrometry and hemispherical electron analysis, a novel technique provides transition state and geometrical information on collision reactions.Combining a crossed molecular beam with mass spectrometry and hemispherical electron analysis, a novel technique provides transition state and geometrical information on collision reactions.


Many schools across the United States and Canada are now implementing response-to-intervention (RTI) as a means to address the needs of students who struggle with reading, writing, or math by using dual discrepancy (i.e., low ability and little to no progress over time with targeted intervention programming) as a means to classify for learning disability. This project represents a longitudinal study of a Pacific Northwest elementary school, which designed its own RTI model in 2006 and has worked to implement a tiered-intervention process for literacy skills. Three children represent the purposeful sample as to how they progressed through tiered programming. The authors discuss the school's RTI processes and makes recommendations as to how the model could evolve to better facilitate instruction and assessment as children move through the tiers.


Abstract : This report presents the results of a series of light-scattering measurements on small, spherical particles of a known size distribution and index of refraction. The purpose of the study is to provide additional data for the evaluation of the multiple-scattering model used in a plume visibility code currently being developed for the Air Force. Measurements of both singly and multiple scattered laser radiation from aqueous suspensions of spherical latex particles were performed at several optical depths. Included are descriptions of the light-scattering apparatus and sample preparation techniques used in the study. Also, sample results of the experiments are presented in graphical form with normalized scattering intensity as a function of scattering angle.


The results of the present examination of the relationship of directivity with element spacings of linear, rectangular, and hexagonal arrays indicate that element spacings for optimal directivity vary with scan angles; this is especially true in the case of changes in aperture sizes and the appearance of grating lobes in the visible space. Grating lobe effects are more pronounced for isotropic than for directive element arrays. Directivity decreases as the beam scans off from boresight, and rapidly diminishes for scans over 30 deg. The hexagonal array has higher directivity for scans of less than 20 deg, and the linear array for those over 30 deg.


Metal dusting is catastrophic carburization process, which causes metallic materials to disintegrate into particles of graphite, carbides and metal dust. This type of degradation typically takes place in the temperature range 450-800°C in gaseous atmospheres of high carbon activity. The resistance to metal dusting can be improved by increasing the amount of silicon in a metallic material. The silicon content of an alloy is typically kept below about 2%, because it adversely affects the mechanical properties of the material; however, higher concentrations of silicon can be alloyed into the surface layer or applied as a protective coating. In this work, silicon was introduced into the surface of Alloy 800H with a 1.5 kW high power diode laser. The behaviour of the laser-treated alloy was studied in a metal dusting environment consisting of 80% CO and 20% H2 at 650°C. The results suggest that silicon protects the alloy by modifying the surface layer of oxide. The laser treatment also changes the microstructure of the alloy, increasing the diffusion of chromium to the surface and favouring the formation of protective chromium oxide.Metal dusting is catastrophic carburization process, which causes metallic materials to disintegrate into particles of graphite, carbides and metal dust. This type of degradation typically takes place in the temperature range 450-800°C in gaseous atmospheres of high carbon activity. The resistance to metal dusting can be improved by increasing the amount of silicon in a metallic material. The silicon content of an alloy is typically kept below about 2%, because it adversely affects the mechanical properties of the material; however, higher concentrations of silicon can be alloyed into the surface layer or applied as a protective coating. In this work, silicon was introduced into the surface of Alloy 800H with a 1.5 kW high power diode laser. The behaviour of the laser-treated alloy was studied in a metal dusting environment consisting of 80% CO and 20% H2 at 650°C. The results suggest that silicon protects the alloy by modifying the surface layer of oxide. The laser treatment also changes the microstructu...


Post-occlusive hyperaemic response of cutaneous microcirculation at a site on the volar surface of the forearm 4-5 cm distal to the elbow has been evaluated using the laser Doppler perfusion imager. Nine healthy young subjects were studied following three types of externally applied loading conditions: (static) pressure only, combination of pressure and shear, and (dynamic) combination of pressure and cyclic shear; each applied for a duration of 3 minutes. Pressure loading of 172 mmHg was applied, with and without the application shear stresses. For dynamic loading, cyclic shear was applied at a rate of 1 Hz. Multiple scans were conducted over an area of 1400 mm/sup 2/ during the first 400 to 600 seconds of the post-occlusion period. Peak hyperaemic flow was established immediately after occlusion for the static loading conditions, while this peak flow (at 204% resting level) was maintained for a longer period of time after the application of cyclic shear. The half-life of hyperaemic response was observed within 100 seconds post-occlusion after static loading but was about doubled after dynamic loading. It was also found that hyperaemic flow did not decay following a single exponential decay pattern, but can be better represented with two exponential decay time constants. The observed adversity effect of dynamic loading to tissue prompts a reevaluation of the strategy in pressure sore prevention.


The utility model relates to a magnetic connector device. The magnetic connector device comprises a first connector and a second connector in abutting with the first connector, wherein the first connector comprises a first insulation body, multiple first terminals, a first metal shielding casing and at least a first magnetic unit, the first insulation body has a first abutting face, the first metal shielding casing has an elastic contact member arranged on the first abutting face, the second connector comprises a second insulation body, multiple second terminals, a second metal shielding casing and at least a second magnetic unit, the second insulation body has a second abutting face, the second metal shielding casing has a contact sheet arranged on the second abutting face, the first magnetic unit and the second magnetic unit realize mutual magnetic attraction which enables the elastic contact member of the first metal shielding casing to abut with the contact sheet of the second metal shielding casing and enables the first metal shielding casing and the second metal shielding casing to realize stable contact for effective grounding connection and the electromagnetic shielding protection effect.


KTP planar optical waveguide was fabricated by combining He+ ion implantation with Rb-K ion exchange in pure RbNO3. The lattice damage induced by He+ ion implantation and influence of ion implantation on ion exchange waveguide were studied. TRIM'2003 code was used to simulate the process of 2.0 MeV He+ ion implantation, the profile of He+ ions concentration as well as the defective lattice versus depth were estimated. The dark mode spectra of the waveguide were measured by the prism-coupling method at wavelength 633 and 1539 nm. The refractive index profiles in the novel waveguide were reconstructed by analyzing dark mode spectra and an increased index in the waveguide region together with a decreased index barrier in damaged layer was obtained. The influence of irradiation damage on the Rb distribution was investigated and analyzed by means of RBS technique.


The evolution of gypsum bare rock surfaces is the result both of volume changes of the outer rock layer and mass wasting by dissolutional processes. Some unusual weathering processes indu-ce an increase in the volume of the outer gypsum layer, resulting in the development of a "weathering crust" and of characteristic forms such as small ridges and bubbles. However, the more typical erosional forms are dissolutional ones of karren type, which are commonly intercon-nected, or superimposed upon the previously described forms. In this chapter a classification system is proposed and discussed, within which the magnitude, order and geometry of the different karren forms are outlined, and the related lithofacies and main morphogenetic processes are examined.


A completely automatic, computer‐controlled apparatus for the determination of doping profiles in silicon has been set up. Doping is determined by resistivity and Hall measurements associated with the subsequent removal of controlled thin layers of material. Anodic oxidation and subsequent oxide stripping by chemical etching has been chosen as the most controllable peeling technique. Electrical measurements are automatically detected and both carrier concentration and mobility values are plotted versus depth. A set of empirical parameters are provided to fit mobility‐concentration data for P, B, and As available in the literature, with analytical expressions. In this way, comparison with experimental values detected in the profiling operation can be readily made and information on the presence of lattice imperfections can be obtained. A new technique for sample preparation, which uses an ultrasonic drill for mesa etching the van der Pauw pattern, is also described. With this apparatus the critical and tim...


High grade gliomas (HGG) are aggressive primary brain malignancies typified by diffuse invasion, genetic heterogeneity, and a universally fatal outcome. MRI-defined contrast-enhancing (CE) tumor burden serves as the clinical standard that guides maximal surgical resection and post-therapy response assessment. However, HGGs also comprise an invasive non-enhancing (NE) tumor margin that extends beyond the CE core and harbors the cells that contribute to recurrence. Sampling restrictions have hindered the comprehensive study of these NE HGG cell populations driving tumor progression. Herein, we present an integrated multi-omic analysis of 313 spatially matched multi-regional CE and NE tumor biopsies from 68 HGG patients, performing whole exome and RNA sequencing of both IDH wild-type and IDH mutant HGGs. We report spatially restricted molecular profiles in IDH-mutant HGG, highlighting a concern for sampling bias given the importance of molecular diagnosis and prognostication in IDH-mutant HGG. Regardless of IDH status, we found that NE tumor regions harbored the highest proportion of private mutations, which reflects an increased development of regional genomic complexity in infiltrative tumor. The multiregional genomic profiling of our IDH wild-type HGG cohort reveals that EGFR and NF1 somatic alterations occur as mutually exclusive events in 98.7% of tumors. However, we resolved rare low allele frequency co-alterations of EGFR and NF1 within the NE region. We find this co-occurrence enriched in recurrent tumors, pointing to the early emergence of NF1 inactivation in the NE regions. We constructed genomic models predictive of recurrent disease from both NE and CE regions, which highlight the occurrence of clonal EGFR copy number alterations and NF1 loss as clonal or subclonal events, respectively, emphasizing the regional and temporal complexity of well-studied canonical driver alterations. We detailed the spatially unique acquisition of multiple distinct EGFR alterations giving rise to intra-tumoral EGFR mosaicism, a challenge in the implementation of EGFR directed therapies. Our study also identified two transcriptomic clusters delineated by the significant overrepresentation of neuronal (NEU) and glycolytic/plurimetabolic (GPM) pathway-based functional states in the NE region. NE regions of the NEU subtype harbor the greatest proportion of private mutations, suggesting these infiltrative tumor cells accumulate alterations without clonal expansion. GPM populations conversely displayed a less branched phylogeny and were transcriptionally enriched in immune cell signatures. This phenotypic dichotomy between GPM and NEU populations supports the growing body of evidence that invasive GBM cells either take on a neuronal phenotype for active invasion or a more metabolic phenotype involving interaction with astrocytes, other glial cells, and infiltrating immune cells.
 Citation Format: Mylan R. Blomquist, Leland S. Hu, Fulvio D'Angelo, Taylor M. Weiskittel, Francesca P. Caruso, Shannon P. Fortin Ensign, Christopher Sereduk, Gustavo De Leon, Lee Curtin, Javier Urcuyo, Ashlynn Gonzalez, Ashley Nespodzany, Teresa Noviello, Jennifer M. Eschbacher, Kris A. Smith, Peter Nakaji, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Devi Patra, Naresh Patel, Mark Lyons, Kliment Donev, Maciej Mrugala, Alyx Porter, Anna Lasorella, Kristin R. Swanson, Michele Ceccarelli, Antonio Iavarone, Nhan L. Tran. Multiregional sampling of high grade glioma identifies regional biologic signatures [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1507.


A self-locking nut with an open slot matched with a single screw is disclosed, which comprises a hexagonal-prism-shaped nut and a locking screw, wherein the hexagonal-prism-shaped nut is provided with an open slot at a corner line; the thin side of a non-working contact surface is provided with a through hole between a large thread and an outer corner; the thick side of a working contact surface is provided with a screw hole corresponding to the through hole; the thread section of the locking screw penetrates through the through hole to be matched with the screw hole, so that the thin side of the non-working contact surface elastically deforms on the root part of the open slot, and the large thread and the external thread of an working shaft are ensured not to rotate, thereby acting a self-locking function. The self-locking nut with an open slot matched with a single screw disclosed by the utility model has the following advantages that: a problem of the precise self-locking of the screwed nut on any position is solved via an ingenious structure consisting an open slot and a single screw; and the self-locking nut with an open slot matched with a single screw is easy to manufacture, convenient to carry and use, simple in structure, and novel in conception.


The housedhold robot shows wider practice situation than industrial robot. This paper presents a visual system of household robot based on optic-electric hybrid system. A union transforms correlator can realize the shift invariant of target image; the synthetic recognition function and Winner Take All network will build cascaded neural network so as to realize distortion invariance of target image. In this paper the principle of the method and its implemental issues are addressed, and it proves the feasibility. This system will certainly provide an effective method for real-time pattern recognition of multi-target.


A blind signature scheme allows a user to obtain a signature on a given message without revealing any information about the message to the signer. The idea of blind signature was first introduced by Chaum at CRYPTO 1982. Blind signatures can be used in many applications, such as e-voting. Recently, Chakraborty and Mehta proposed a new blind signature scheme (Chakraborty-Mehta scheme) based on the elliptic curve discrete logarithm problem. They asserted that their blind signature scheme is secure. In this paper, however, we will present two simple but powerful attacks on their blind signature scheme. The attacks show Chakraborty-Mehta blind signature scheme is not secure.


MOROWITZ, HAROLDJ.(Yale University, NewHaven,Conn.), ANDJACKMANILOFF. Analysis ofthelife cycle ofMycoplasma gailisepticum. J.Bacteriol. 91: 1638-1644. 1966.-Aseries ofelectron microscope observations onMycoplasma gallisepticum strain A5969havebeenmadebyuseofthin-section techniques and negative staining. Themethods presented aconsistent picture ofa postdivision cell, whichcontains a fibrillar nuclear region, surrounding ribosomal region, highly organized bleb atoneendofthecell, granular infrableb region, andboundingunit membrane. Cell division commenced with theappearance ofasecond infrablebareaattheendofthecell opposite theoriginal bleb. A newbleb grewinthis area, andthecell thenelongated. Thenuclear material segregated into twoparts separated byabandofribosomes. Aconstriction appeared, inthis central ribosomepacked area, leading totheformation oftwodaughter cells. Thefollowing was noted: thecells wereverysmall(volume, 5X 10-14 cm3); eachcell washighly structured andstrongly ordered; andthereplication appeared tobea veryprecisely programmed series ofevents. Fromthepoint ofviewofcellular ultrastructure, cellreplication isthetimesequence of structures, starting right after onecell division andterminating after thenextcell division. Fora total viewoftheprocess, these structures must thenbecorrelated withthesequence ofchemical reactions occurring inthecell overthesametime cycle. Mycoplasma gallisepticum strain A5969[an avianpleuropneumonia-like organism (PPLO)] hasproven tobeideally suited forthestudy of cellular ultrastructure during replication for several reasons. (i)Thecell's finestructural elements havebeencatalogued andcontain several easily identifiable microstructures which canbeconveniently studied bythin-section electron microscopy (1,5).(ii) Thecell contains averywell-defined polar body(the bleb), sothat a reference point exists fortheorientation ofall otherstructures. (iii) Thecellappears tobe extremely wellordered withrespect toitssub'Parts ofthis workweresubmitted byJackManilofftotheGraduate School, YaleUniversity, in partial fulfillment ofrequirements forthePh.D. degree. 2Present address: Chemistry Department, Metcalf Research Laboratory, BrownUniversity, Providence, R.I.


ABSTRACT On the high-elevation, low-relief Bogong Plateau, within the Eastern Uplands in Victoria, well-preserved diverse macrofloras and microfloras have been recovered from Eocene sediments at two sites underlying Eocene–Oligocene basalts. Estimates of mean annual temperature (MAT) were made from the floras at each site, using a novel method calculating probability density functions and maximum likelihood co-occurrence climate envelopes of the nearest living relatives of multiple fossil taxa, and the proportion of non-toothed rather than toothed leaf margins of all fossil leaves. The most likely scenario is an Eocene MAT at Bogong Plateau of 18°C, consistent with the cloudy mesothermal montane environment indicated by the abundance of tree ferns and other flora. From the MAT, the maximum Eocene paleo-elevation of the flora sites on the plateau can be calculated using the 'lapse rate' method, and was probably around 550−700 m above sea-level (∼1000 m lower than at present), but with large uncertainties for these estimates. The macrofloras accumulated in stream valleys, so the maximum elevation of the Eastern Uplands at the time was greater, matching other estimates of >800 m. Uplift to the present elevation probably occurred ca 8–4 Ma, so the alpine environment on the high plains dates to this time, and the high-altitude biota has therefore developed in the last 8 million years.


Abstract Bidirectional reflectance characteristics of a wheat and a rice canopy were studied using radiometric measurements over the two canopies with an Exotech Radiometer Model 100AX. For both rice and wheat, the measurements exhibited significant variations in reflectance amplitude for varying viewing zenith angles and their values decreased from backward to forward scattering direction. Reflectance obtained its maximum value in the backscatter direction for the viewing angle that corresponds approximately to the solar zenith angle at the time of measurements. Canopy background condition (irrigated or non‐irrigated) was an important determining factor of canopy reflectance particularly in the near‐infrared region of the solar spectrum. Furthermore, bidirectional response characteristics of a vegetation canopy were influenced by the amount of vegetation cover.


This paper presents a high level view of how clusters are being used in large number of domains for preserving and protecting the data. Because of these , clusters are being exposed to many attacks coming from open network.. Hence there are many methods to design a privacy preserving clusters. To ensure these preserving clusters, cluster validity measurements are done for different type of Data. Protocols are used to do the privacy preserving. The clusters analysis are used in banking sector for identification of the bank customer profile. Algorithms are used to find the Sensitive data before making the individual data into clusters of data .and then the privacy is applied only on these sensitive data.


In the study we designed the novel‐structure field emission lamp (FEL), side‐anode FEL. Cathode and anode electrodes are both on one glass substrate. Because the lighting mode of the side‐anode FEL is reflection mode, so the lighting efficiency and uniformity are better than other common structure.


We report on the design of the rf photoinjector of the Linac Coherent Light Source (LCLS). The rf photoinjector is required to produce a single 150 MeV bunch of {approximately}1 nC and {approximately}100 A peak current at a repetition rate of 120 Hz with a normalized rms transverse emittance of {approximately}1 {pi} mm-mrad. The design employs a 1.6-cell S-band rf gun with an optical spot size at the cathode of a radius of {approximately}1 mm and a pulse duration with an rms sigma of {approximately}3 ps. The peak rf field at the cathode is 150 MV/m with extraction 57 {degree} ahead of the rf peak. A solenoidal field near the cathode allows the compensation of the initial emittance growth by the end of the injection linac. Spatial and temporal shaping of the laser pulse striking the cathode will reduce the compensated emittance even further. Also, to minimize the contribution of the thermal emittance from the cathode surface, while at the same time optimizing the quantum efficiency (QE), the laser wavelength for a Cu cathode should be tunable around 260 nm. Following the injection linac the geometric emittance simply damps linearly with energy growth. PARMELA simulations show that this design willmore » produce the desired normalized emittance, which is about a factor of two lower than has been achieved to date in other systems. In addition to low emittance, we also aim for laser amplitude stability 1% in the UV and a timing jitter in the electron beam of 0.5 ps rms, which will lead to less than 10% beam intensity fluctuation after the electron bunch is compressed in the main linac.« less


Abstract We studied ontogenetic shifts in sexual dimorphism and female reproduction in the Reeves's Butterfly Lizard, Leiolepis reevesii (Agamidae), from Hainan, southern China. The smallest reproductive female was 84 mm snout–vent length (SVL). The largest female and male were 136 mm and 166 mm SVL, respectively. Sexual dimorphism in head size and tail size was evident in adults, with adult males having larger heads and longer tails than did adult females of the same SVL. Head size relative to SVL was greatest in hatchlings and smallest in adults, with juveniles in between. Tail length relative to SVL was shorter in hatchlings than in juveniles and adults but did not differ between juveniles and adults. Females produced a single clutch of 2–8 eggs per breeding season stretching from mid-April to mid-July. Clutch size, egg mass, and clutch mass were all positively related to female SVL. Egg mass was negatively correlated with clutch size when holding female SVL constant, and egg length was negatively correlated with egg width when holding egg mass constant. Larger females increased reproductive output primarily through production of more and larger eggs (and hence heavier clutches). Males are the larger sex in L. reevesii presumably because (1) the selective pressure toward increased male size is strong; (2) the selective pressure toward increased female size is comparatively low; and (3) somatic growth is more likely to be constrained by reproduction in smaller females because of a negative correlation between relative clutch mass and SVL.


Interpreting popular music into Sign for deaf audience members has become increasingly common. Interpretation of the songs permits the deaf community to participate in a congenial forum where significant social and political views are aired. Fifteen interpreters were interviewed at a Hudson Clearwater Festival and their ideas recorded on popular music interpreting and its differences from speech interpreting and transliterating. Nineteen members of their deaf audience were interveiwed for their reactions and opinions. The central concerns of the deaf audience differ somewhat from those of the interpreters. The future of concert interpreting will be determined not by educators or by the benevolence of the hearing world but by economic factors such as the appeal of sign language "music" to paying audiences, both deaf and hearing.


With the rapid developments in wireless communication technology, people access Internet applications anytime and anywhere. Recently, academics and industry researchers have been paying increasing attention to the video streaming services over high-speed rail environments. For providing the quality of service of video streaming, we present a novel mobile proxy architecture for improving the system performance over high-speed trains in Long Term Evolution-Advanced networks. The mobile proxy not only saves the wireless bandwidth consumption between the base station and the high-speed train but also reduces the starting delay time of the video. Moreover, we propose a score-based replacement scheme in the memory management of the proxy server based on the feature of the video. Our simulation results demonstrate that the proposed scheme provides a better performance than other existing cache management schemes.


During ground fault conditions, the flow of current to earth will produce gradients in and around a substation. The magnitude of gradients caused are dependant upon the ground resistance of the substation. Such gradients, if large enough will cause bodily harm to a person in and around the substation. To determine dangerous situations if any, monitoring of the ground resistance is necessary. An instrument for such monitoring of the ground resistance, the Microcontroller Based Ground Resistance Monitor, has been developed. The Monitor measures the value of ground resistance after every 24 hours and stores in memory. The voltage used for the measurement and the time of measurement are also recorded. Readings will be recorded automatically for over a period of three years after which readings will be overwritten. The Monitor also calculates the mean and standard deviation squared of the most recent 64 readings of the ground resistance. An LED is switched 'on' if the present value of ground resistance exceeds the preset maximum value. An error analysis and the results of testing the Monitor in a laboratory setting are also outlined. MICROCONTROLLER BASED GROUND RESISTANCE MONITOR


In order to realize intelligent operation and maintenance, it is necessary to convert the business behavior log into a digital form that can be processed by the intelligent decision model. For the embedding representation of business behavior characteristics, data fusion based on behavior type and sparse embedding representation based on discrete normalization are given, and the input data of business behavior is vectorized into 152-bit sparse vector. Combined with the advantages of knowledge graph, data fusion and dense embedding representation based on knowledge graph are proposed, and the input data is vectorized into a dense vector represented by 151 real numbers. As can be seen from the embedding results, the scale of one-dimensional vector obtained by the two embedding methods is approximate, and compared with the sparse integer vector, the dense vector can more sufficiently express business behavior characteristics and are more suitable for deep learning.


The need for more bandwidth for a broad range of purposes necessitates research into how radio refractivity, multipath fading, and geoclimatic variables affect terrestrial and satellite propagation links. In this study, a geographical distribution approach to radio refractivity and fade depth over five locations in Nigeria—Akure, Enugu, Jos, Minna, and Sokoto based on five-year (2017–2021) measured data of atmospheric pressure, relative humidity, and temperature—at two levels (ground surface and 100 m heights). The results demonstrated the percentage occurrence of the dry terms dominating the radio refractivity constituent at the surface level, with a minimum and maximum contributions of about 78 and 92%, while at heights of 100 m, the percentage occurrence of the dry terms dominated the radio respectively refractivity constituent, contributing a minimum of about 79% and a maximum of about 92%. The spatial distribution reveals that, regardless of height, the tropical rainforest (TRF) and freshwater swampy mangrove (FWSM) regions reported the highest values of radio refractivity. The statistical estimate shows that fading values can differ by as much as 1.5 dB, especially near the TRF and FWSM coastlines, even during clear air conditions. The current findings will be helpful for budgeting Earth-space microwave links, particularly for the rollout 5G and future-generation microcellular networks in Nigeria.


Four preservatives,EDTA,potassium sorbate,ethylp-hydroxybenzoate and Nisin,were selected from 7 samples through the single factor test,which obviously improved the shelf-life of fish sponge cake.The best combination of the four preservatives was obtained through orthogonal test as:0.03% EDTA,0.05% potassium sorbate,0.01% ethylp-hydroxybenzoate and 0.02% Nisin.


Deep metallic surface relief diffraction gratings are shown to couple radiation to surface plasmon polaritons when transverse magnetic radiation is incident in a plane orthogonal to the grating wave vector. This sharp resonance for a deep sinusoidal surface profile is explored using modeling programs and its presence is confirmed experimentally for a silver grating in the visible part of the spectrum.


Objectice To explore the masticatory efficiency of the hollow obturators with normal over bite and cross bite of posterior teeth.Methods Twenty-noe patients with unilateral maxillectomy defects for malignant tumors were included in this study. All received a pair of hollow obturaror prostheses with normal over bite and cross bite of posterior teeth. Masticatory efficiency of the patients who wear the two kinds of hollow obturators was evaluated respectively with optical method.Results The hollow obturators with cross bite of posterior teeth presented statistically significantly better masticatory efficiency than which with normal over bite (t=2.605,P0.05).Conclusion The posterior teeth of hollow obturators could be arranged in cross bite, and thus can not only shorten the arm of force and diminish the leverage effects, but also get a better masticatory efficiency.


We investigated the efficiency of coherent upstream large-amplitude electromagnetic wave emission via synchrotron maser instability in relativistic magnetized shocks using two-dimensional particle-in-cell simulations. We considered a purely perpendicular shock in an electron–positron plasma. The coherent wave emission efficiency was measured as a function of the magnetization parameter σ, which is defined as the ratio of the Poynting flux to the kinetic energy flux. The wave amplitude was systematically smaller than that observed in one-dimensional simulations. However, it continued to persist, even at a considerably low magnetization rate, where the Weibel instability dominated the shock transition. The emitted electromagnetic waves were sufficiently strong to disturb the upstream medium, and transverse filamentary density structures of substantial amplitude were produced. Based on this result, we discuss the possibility of the wakefield acceleration model to produce nonthermal electrons in a relativistic magnetized ion–electron shock.


The aim of this investigation was to evaluate the long-term effects of aging in water on the physical properties of a new class of commercially available dental polymer composites. The selected product consists of a bisphenol A glycidyl methacrylate (Bis-GMA) resin diluted with triethylene glycol dimethacrylate (TEGDMA) and reinforced with long E-glass fibers, specifically developed for prosthetic dental bridges. Samples were prepared according to a standard procedure suggested by the producer, and aged in water at 37°C and 70°C up to 32 weeks. Samples were periodically tested in order to assess their mass variation, static flexural modulus and strength, fatigue resistance, and dynamic mechanical thermal behavior. Experimental results evidenced that aging caused two simultaneous phenomena, having opposite effects on the specimen mass. In fact, composites absorbed a certain amount of water (up to 0.8 wt% at 37°C and 1.2 wt% at 70°C) but at the same time a mass loss was detected, which could be attributed to a release of unreacted monomeric species and fragments generated by polymer chain degradation (especially at 70°C). Flexural strength strongly decreased during aging in water, reaching 80% and 45% of the initial value for samples aged for 32 weeks at 37 and 70°C, respectively. Aging practically does not affect flexural modulus, while a sensible reduction of the material fatigue life was observed. Glass transition temperature and the relative activation energy were markedly influenced by the aging in water with effects related to the water uptake and mass loss phenomena.


The reminiscences that recount visits to Beethoven have been treated primarily as sources of biographical information, and there has been much scholarly concern regarding their trustworthiness as historical documents. A significant number, however, use a single plot, that of a quest or pilgrimage, indicating that, in all likelihood, most have been shaped and embroidered by their authors. Precisely because they have been 'fictionalized', these narratives can provide insight into how and why the Beethoven myth managed to overpower history. The article suggests some reasons why the authors' insistence on-and our acceptance of-Beethoven's inaccessibility might be so seductive.


At the present time the problem of preservation of natural environment is the most actual problem, which faces the whole mankind. An important part of the problem of preservation of natural environment is the control of pollution of the World Ocean. Chronic marine pollution can as a result lead to the disruption of the ecological balance of the whole planet. It becomes obvious that in case of further development of these tendencies, life on Earth will be under serious threat. The article deals with the historical aspect of cooperation among states in the counteraction against the marine pollution and the complexity of this problem which has technical, economical, political and legal aspects. Besides, the article describes the current ecological situation in the World Ocean, as well as the concept of the marine pollution, the main sources of pollution, and some principles of the international law of the sea.


Purpose of the study: This study aims to identify the degree of Motivation for Academic Achievement and its Relationship to the Metacognitive Thinking Skills among High School Students in the suburbs of Jerusalem.
Methodology and research methods: To achieve the objectives of this study, the relational descriptive approach was adopted. The sample of this study included (380) high school students (male and female). Data was obtained, analyzed, and processed statistically.
Results: The findings suggested that there were statistically significant differences in the means of the motivation for academic achievement due to gender in favor of females. The results also showed that there were no statistically significant differences at the level of significance (α ≤ 0.05) in the means of the metacognitive thinking skills among high school students due to gender, an average of the former class, or father-mother's educational qualification. Moreover, the results revealed that there was a correlation between the motivation for academic achievement and metacognitive thinking skills.
Scientific novelty: It is clear that metacognitive thinking skills improve the degree of motivation for academic achievement by increasing the capacities of the students to learn and grow their learning motivation. it is considered a strong indicator of academic success. Students with metacognitive thinking skills achieve better academic achievement compared to students who have a lower level of metacognitive thinking skills.
Practical significance: The importance of this study is expressed in the significance of the issue under consideration, as awareness of metacognitive thinking skills increases the capacity to handle and use them in various educational situations.


The present invention describes a battery, the battery having at least one battery module having a bottom side (16), a cooling plate (10), said cooling plate having a top side (20) and disposed in the cooling plate (10) connected to said cooling plate (10) on the top side (20) for the at least one battery module (16) fixing system. In the fixing system having at least one strap (12, 12 '). A bottom side of the cooling plate by means of which the at least one fixing band (12, 12 ') of the at least one battery module (16) fixed to said cooling plate (10), such that the battery module (16) (10) the top side (20) in direct contact. In addition, also it relates to a motor vehicle having such a battery.


Illustration: " Kroppsvärme " , Siri Granfeldt Published articles have been reprinted with the permission of the copyright holder. Abstract Many patients are diagnosed as having chronic heart failure (CHF) and apart from the fact that daily activities are impaired, they are great consumers of health care, and the prognosis is poor. The distinction between acute heart failure (AHF) and CHF may be difficult and is more a question of time rather than severity. The " gold standard " treatment for end‐stage heart failure is heart transplantation. Due to organ shortage this is reserved for selected patients only. Since the introduction of mechanical circulatory support (MCS) more and more patients with progressive CHF have been bridged‐to‐heart‐transplantation. There are MCS systems available for both short‐ and long‐term support. Newer concepts such as ventricular constraint to prevent ventricular remodelling are on the way. We have investigated short‐ (Impella TM) and long‐term (HeartMate TM I and II) MCS and ventricular constraint (CorCap TM CSD) as treatment concepts for all forms of heart failure, the aims being: bridge‐to‐decision, bridge‐to‐transplant and extended therapy, called " destination therapy " (DT). Methods and results In Paper I, the use of HM‐I TM pulsatile MCS in bridge‐to‐transplantation patients in Sweden was retrospectively investigated regarding outcome and risk factors for mortality and morbidity. Fifty‐nine patients were treated between 1993 and 2002. The dominating diagnosis was dilated cardiomyopathy in 61%. Median support time was 99.5 days. 18.6% died before transplantation. Four patients needed RV assist due to right ventricular failure. Haemorrhage was an issue. Six patients (10%) suffered a cerebrovascular thromboembolic lesion. 15% developed driveline infection. 45% of the MCS patients were discharged home while on pump treatment. Massive blood transfusion was a predictor for mortality and morbidity, p<0.001. In Paper II the second generation long‐term MCS, the continuous axial flow pump HM‐II TM , was prospectively evaluated for mortality and morbidity. Eleven patients, from 2005 until 2008, were consecutively included at our institution. One patient received the pump for DT. The median pump time was 155 days. Survival to transplantation was 81.8%. Ten patients could be discharged home before transplantation after a median time of 65 days. Paper III investigated the Swedish experience and outcome of short‐term axial flow MCS, the Impella TM , in patients with AHF. Fifty patients were collected between 2003 and 2007 and divided into two groups: 1. Surgical group (n=33) with cardiogenic shock after …


Sociological works that have served as personal inspirations are listed, noting that, as one's professional career proceeds and one's intellectual capital increases, fewer eye-opening works appear to come along. It is also observed that works in which a new perspective is institutionalized tend to affect the experienced sociologist more deeply than works in which the first exploration of such new perspectives takes place. Particular praise goes to H. H. Hyman's Survey Design and Analysis (1955); J. A. A. van Doorn and C. J. Lammers's Moderne sociologie, systematiek en analyse ([Modern Sociology, Systematic Analyses] 1959); M. Hajoda, Paul F. Lazarsfeld, and H. Zeisel's Marienthal: The Sociography of an Unemployed Community (1971); A. D. Groot's Methodologie ([Methodology, 1961); J. Galtung's Theory and Methods of Social Research (1967); H. Schwartz and J. Jacobs's Qualitative Methodology: A Method to the Madness (1979); Anthony Giddens's Nieuwe regels voor de socioloigsche methode ([New Rules of Sociological Method] 1979); and H. G. v. d. Bunt's Officieren van justitie ([Officer of Justice] 1985), emphasizing their methodological innovations. S. Paul