Trichloroethene (TCE) was reduced with zero‐valence iron and palladized iron in zero‐head‐space extractors. Progress of the reaction in these batch studies was monitored with purge‐and‐trap gas chromatography and a flame ionization detector. When a 5 ppm initial concentration of TCF. reacts with zero‐valence iron, approximately 140 ppb of vinyl chloride persists for as long as 73 days. The concentration of vinyl chloride (approximately If) ppb) remaining with palladized iron is approximately an order of magnitude less than when zero‐valence iron is the reductant. These data suggest that volatile byproducts may be under‐represented in oilier published data regarding reduction with zero‐valence metals. These results also demonstrate that the reduction of TCE with palladized iron (0.05 percent palladium) is more than an order of magnitude faster than with zero‐valence iron. Wilh a 5:1 solution‐to‐solid ratio the TCE half‐life with zero‐valence iron is 7.41 hours. but is only 0.59 hours with the palladized iron.


This paper proposes a new stock-jobbing system named Stock-Master system which based on the SMS(Short Message System) of PSTN. For the real-time Stock Exchange, this system expands the system and the protocol of PSTN(Public Switched Telephone Network) SMS. It adds the trade module of CTSI(Chinese Terminal Service Interface) server, operation trade gateway and professional CP(Content Provider) system. This system adopts the terminal ID(Identification)identification, encrypted 3DES, and the exclusive connection serial number. All these techniques are used to ensure the security of the stock exchange. This paper describes the frame, the physical topology structure, the function and the security design of this system, and analyses its advantages and disadvantages in detailed.


Objective To study the association of long-term statin use and the risk of low-energy hip fractures in middle-aged and elderly women. Design A register-based cohort study. Setting Finland. Participants Women aged 45–75 years initiating statin therapy between 1996 and 2001 with adherence to statins ≥80% during the subsequent five years (n = 40 254), a respective cohort initiating hypertension drugs (n = 41 610), and women randomly selected from the population (n = 62 585). Main Outcome Measures Incidence rate of and hazard ratio (HR) for low-energy hip fracture during the follow-up extending up to 7 years after the 5-year exposure period. Results Altogether 199 low-energy hip fractures occurred during the 135 330 person-years (py) of follow-up in the statin cohort, giving an incidence rate of 1.5 hip fractures per 1000 py. In the hypertension and the population cohorts, the rates were 2.0 per 1000 py (312 fractures per 157 090 py) and 1.0 per 1000 py (212 fractures per 216 329 py), respectively. Adjusting for a propensity score and individual variables strongly predicting the outcome, good adherence to statins for five years was associated with a 29% decreased risk (HR 0.71; 95% CI 0.58–0.86) of a low-energy hip fracture in comparison with adherent use of hypertension drugs. The association was of the same magnitude when comparing the statin users with the population cohort, the HR being 0.69 (0.55–0.87). When women with poor (<40%), moderate (40 to 80%), and good adherence (≥80%) to statins were compared to those with good adherence to hypertension drugs (≥80%) or to the population cohort, the protective effect associated with statin use attenuated with the decreasing level of adherence. Conclusions 5-year exposure to statins is associated with a reduced risk of low-energy hip fracture in women aged 50–80 years without prior hospitalizations for fractures.


This paper proposes and evaluates a built-in position sensor for an electrostatic motor called a dual excitation multiphase electrostatic drive. The built-in sensor operates on a similar principle to typical capacitance-type linear encoders. The sensor system superimposes a high-frequency sensor signal onto a low-frequency driving signal so that it can share the same electrodes with driving operation of the motor. This paper analyses the sensor principle based on a capacitance network model of the motor that allows us to evaluate the linearity error of the proposed sensor system. The sensor was implemented on a prototype motor to evaluate its performance. The experimental results confirmed that the sensor can work successfully by sharing the same electrodes with the driving operation. The linearity error was found to be 24 µm when no driving signal was applied. As the driving signal was applied, the linearity error was found to increase up to 48 µm.


A modern approach to model reduction in chemical kinetics is often based on the notion of slow invariant manifold. The goal of this paper is to give a com- parison of various methods of construction of slow invariant manifolds using a sim- ple Michaelis-Menten catalytic reaction. We explore a recently introduced Method of Invariant Grids (MIG) for iteratively solving the invariance equation. Various initial approximations for the grid are considered such as Quasi Equilibrium Manifold, Spec- tral Quasi Equilibrium Manifold, Intrinsic Low Dimensional Manifold and Symmetric Entropic Intrinsic Low Dimensional Manifold. Slow invariant manifold was also com- puted using the Computational Singular Perturbation (CSP) method. A comparison between MIG and CSP is also reported.


Oxidation of Cp2MoSx, where x = 2, 4, with m-chloroperbenzoic acid gave Cp2MoS2O and Cp2MoS4O, respectively. In Cp2MoS4O the oxygen is attached to the 2-sulfur atom of the S4 ligand; however, an intermediate was isolated and identified as the 1-oxo isomer. It thermally rearranges via first-order kinetics with rate dependence on solvent polarity to give the final 2-oxo product.


A distributed computation is viewed as a partial order on the events that occur at participating processes. Analyzing the structure of a distributed computation can lead to a better design of distributed applications, algorithms, and systems. To this end, this paper identifies two classes of communication patterns that occur in every distributed computation and examines their properties [2]. The first class of patterns consists of local patterns, termed IO and OI intervals, that occur at processes. These local patterns are specified in terms of messages sent and messages received by a process, and are distinguished by the order in which a pair of messages is sent and received by a process. Specifically, an IO interval corresponds to a receive event followed by a send event, and an 01 interval corresponds to a send event followed by a receive event. (Likewise, there are II and 00 intervals corresponding to two receive events, and two send events, respectively.) Clearly, there are numerous IO and 01 intervals at each process in the computation. At each process there are also application-specific distinguished events, which define the durations between successive such events. An IO or 01 interval of interest to an application is one that satisfies a certain application-specific relationship on the durations in which the send and receive events identifying the interval occur. Application-specific predicates can be defined on how an IO or 01 interval at one process is related to an IO or 01 interval at another process. The use of such predicates on IO and 01 intervals at different processes allows IO and 01 intervals to be used as building blocks to formulate the second class of patterns, which is comprised of two global patterns, termed segments and paths. These two global patterns occur across processes in a distributed computation and signify the flow of information and coupling among the events at different processes. Segments and paths are generalizations of causal chains. While a causal chain captures only the causality relation, certain other message sequences in a distributed computation also play a significant role in the analysis of a distributed computation. By controlling the predicates on how IO and 01 intervals at different processes are used to define segments and paths, different types of segments and paths can be defined. Several key concepts and structures characterizing distributed computations are special cases of and can be exMukesh Singhal National Science Foundation Arlington, VA 22230, USA


(b) Lower T. component Higher T. component Selecting Orion Molecular Cloud 2 and 3 (OMC-2/3) as our study field, we conducted an X-ray imagingspectroscopy observation (0.5-8 keV) using Chandra / ACIS-I and a NIR imaging observation (J, H, K ) using the University of Hawaii 88-inch telescope / QUIRC. From the X-ray image, 385 sources were extracted at Fx>10 ergs/s/cm2, while from the NIR image 1448 sources were detected at K <16.0 mag.


A high peak current, low emittance, short pulse electron beam can produce intense, laser-like radiation in a single pass through a long periodic magnetic structure. The construction of such free-electron lasers (FELs) based on self-amplified spontaneous emission (SASE) has become feasible by recent advances in accelerator technologies. Since SASE FELs do not require any optical components they are promising sources for the generation of intense, sub- picosecond laser pulses which are continuously tunable over a wide wavelength range in the vacuum ultraviolet (VUV) and X-ray region. In the first phase of the VUV-FEL (phase I) at the TESLA Test Facility at DESY, SASE was achieved for the first time in the VUV at wavelengths between 80 and 180 nm. The concept of the VUV FEL at DESY and first experimental results are presented. The second phase of the TESLA Test Facility (phase II), which includes an increase of the electron beam energy to 1 GeV, aims at the construction of a SASE FEL operating in the soft X-ray region. An overview of the current status and the activities toward a soft X-ray FEL user facility is given.


The magneto-mechanical harvesters with different magnetostrictive materials as an active element have been modeled to convert unwanted vibration energy to electricity, promising a high energy density. The performance of the developed velocity-driven harvesters has been investigated while they were excited by almost the same frequency. The Finite Element Method (FEM), ANSYS Software, was employed to analyze the dynamic behavior of the harvesters numerically. The results show that magnetostriction coefficient and magnetic permeability play significant role in harvested power. Analytical analysis also promised the maximum power density of 43.1 mW/c$m^{3}$ with external resistive load of 0.1 $\Omega$ in Terfenol-D harvester which is almost 1.37 and 4.4 times of Galfenol and Permendur, respectively. Consequently, Terfenol-D is the most suitable harvester for low impedance load and high power device, and Permendur is suitable for high impedance and low power devices.


Undoped and phosphorus-doped diamond thin films grown by Microwave Plasma-enhanced Chemical Vapour Deposition (MPCVD) on Ib {111}-oriented diamond substrates have been studied by confocal micro-Raman spectroscopy and confocal Raman imaging. A distinct Raman peak, broader and 6 cm -1 lower than the zone-centre optical phonon line of the substrate, was nearly systematically detected showing that in most cases the homoepitaxial layers were under an intense tensile strain. The magnitude of this strain increased with deposited thickness. In the thicker films, it was further observed that a network of oriented cracks could relieve the internal stress. These results suggest that tensile strain is a general feature of defective {111}-oriented CVD diamond homoepitaxial layers.


Infrared characters of all the host galaxies with the H2O megamaser have been studied. The most striking feature is the anticorrelation of S(60)/S(100) versus S(12)/S(25), and S(25)/S(60) versus S(12)/S(25). The anticorrelation in the flux density ratio can been explained by coexistence of large and very small dust particles. The latter, which are heated by absorption of single photon, are believed to be responsible for the bulk of 12 µm radiation. If the photon energy of the host galaxy is small, this implies large S(12)/S(25) and small S(60)/S(100). However, when photon energy density becomes larger, the infrared spectrum will peak at wavelengths ⩽ 100 µm and enhance emission at 25 µm. As a consequence small S(12)/S(25) and large S(60)/S(100) are observed.


To study the different permeability characteristics of rock,transient permeability tests of limestone and diorite were carried out.The permeability evolution and the relation between pore pressure and time of rock specimens during the complete stress-strain course were investigated.The strain-permeability equations of rock specimens during the deformation and failure course were set up.Finally,the penetration mechanism of two types of rocks was analyzed.The result shows that the phenomenon of the sudden jump of permeability occurs at the peak strength and keeps very low unchanged permeability before the peak strength for diorite.But limestone's permeability gradually increases with increasing deformation before and after the peak strength.The fitted equations for the strain-permeability curve more deeply describe the permeability characteristics in compressive failure.The relation between pore pressure and time is quartic polynomial with one unknown.The rock permeability has relations with the stress state and the internal structure and the mechanical properties of rock.


Abstract Spanish montmorillonites from Frente Archidona were used to demonstrate the determination of charge density, CEC and, in mixtures, the montmorillonite content by the aikylammonium method. Special attention is directed to heterogeneous montmorillonites and the determination of the charge density distribution. Some problems which arise by application of the method are discussed: relations between layer charge and cation densities, particle size corrections, microstructures and unsymmetric charge distributions in the interlayer spaces.


Traditionally, geoscientific data collected by GeoScience Victoria (GSV) were held in databases focussed on providing the content for maps and their accompanying legends. A wealth of information would be stored in free-text legend fields or geological reports. Analysis of these data using other software is difficult and this approach can lead to inconsistent or contradictory systems. GSV has redesigned its geological information systems, based on a data model that describes true geological entities and concepts. Consequently, information stored by GSV can be more readily used for a variety of purposes and by a variety of users, and the information model is not constrained by the implementation requirements of a particular vendor. Research was conducted to identify models generated by other groups or agencies before adopting the North American Geologic Map Data Model - Conceptual Model 1.0. This model provided the foundation for a logical model explicitly defining the geoscientific concepts with respect to GSV's business requirements. The geoscientific application of the Geography Mark-up Language .GeoSciML, was used as a reference during the logical modelling. An extensible pair of aspatial and spatial databases was constructed. Web-services, including Open GIS Consortium (OGC) compliant web map services and web feature services, will be used to deliver data to client applications. These databases will enable GSV to conduct it's own work and deliver its data to external parties using international standard exchange languages such as GeoSciML.


Electron microscopaic examination of the prostatic epithelium of castrated rats with or without subsequent administration of testosterone led to the following results. 1. In rats castrated and left untreated for a month, the epithelial cells were evidently atrophied, the electron density of the cytoplasm was lowered, the endoplasmic reticulum was faded out, and the mitochondria were reduced in size. 2. When such rats a month after castration were given per cutem 1-10 μg of testosterone solution in olive oil, no perceptible finding of recovery from the changes was obtained, but after 100 μg of it, the reappearance of endoplasmic reticulum was obvious, the mitochondria were re-enlarged and their internal structure was again definitely observable.


Increasing End Stage Renal Diseases (ESRD) require renal transplants or dialysis as the effective treatment of choice under current circumstances. Biomechanical microenvironment plays an important role in tissue development and pathogenesis. Accumulation of excessive extracellular matrix (ECM) alters tissue mechanical properties which leads to organ failure Forces potentially operate in fibrosis include hydrostatic osmotic and stretch pressure. Failure to resolve injury and restore haemostasis gives progressive fibrosis which alters the mechanical environment that is matrix deposition and stiffness. Mechanical environment operates organ function and which is a physiological system A potential regenerative approach is an in-situ repair which is an attractive strategy.

High hydrostatic pressure has potential to disrupt structure of ECM through protein denaturation. It achieves devitalisation without damaging biomechanical properties. Intra luminal hydrostatic pressure elevation over 20 -30 cms. H2O causes degenerative changes in tissues and, fibrosis When HP applied  by use of hydrostatic fluid column ,hypoxic conditions created that alters cell function, inhibits collagen matrix production and suppress  the differentiation of fibroblast to myofibroblast phenotype. Therefore, the priority to treat CKD is to therapeutically manipulate fibrosis and restore its micro vascular circulation.

The cells are mechanically compressed between a strong renal capsule and hydrostatic pressure created by artificial obstruction created at the pelvi-ureteric junction. These act like close chamber pressure. The proposed therapy presents an hypothesis, where the excessive elevation of intraluminal hydrostatic pressure will degenerate renal fibrosis and restore microcirculation functionality to eventually help to rebuild a healthy kidney from native stem cells.

16th World Nephrology Conference August 20-21, 2020 Webinar

Biography

 Dr..Shrikant L. Kulkarni completed his M.S.(General Surgery)  in 1975 from B.J.Medical College Pune,Maharashtra India. The bachelor's degree M.B.B.S. completed from Miraj Medical College. Since 1971 he has worked at several government hospitals like the Wanless Hospital Miraj, Sangli General Hospital Sangli, Sassoon Hospital Pune and multispecialty hospitals like Ruby Hall Clinic, Pune and Jahangir Nursing Home, Pune. For the last 35 plus years he has been working at his own hospital at Chinchwad, Pune Maharashtra India.


Dose distributions produced by using proton and ion beams in radiation therapy conform closely to the target volume maximizing the sparing of adjacent normal tissues and sensitive structures. Worldwide, through 2001, over 30,000 patients have been treated with proton beams and over 3,500 with ion beams. In 2002, there are 21 operating proton therapy facilities, including several hospital‐based dedicated facilities. Seven of these facilities are limited to treating eye tumors only. Carbon ions are available at two facilities in Japan and one in Germany. All existing centers use either a cyclotron or a synchrotron and several facilities have one gantry or more to provide beams at any angle to the patient. For several treatment sites, there are good long‐term follow‐up results, increasing the interest worldwide in having proton or ion beams more readily available. As a result many new facilities are under construction or being planned and some existing facilities are being upgraded.


An experiment was conducted to examine consumer response to black models displayed in promotional material. The study extends prior research on the effects of black models by determining (1) the sales response of white consumers in the Deep South to black models and (2) the sales response of black consumers to black models.


Of formula (I) a cyclic sulfate ester prepared by ethylene glycol at 150-250 deg.] C The reaction was concentrated sulfuric acid of formula (II). In the formula (I) or (II), R1, R2, R3, R4, R5 and R6 are the same or different, may be hydrogen, halogen, alkyl, alkoxy, aryl group, aryloxy group or an alkoxycarbonyl group, and n is 0 or 1.


In a recent keynote address on future of ergonomics, Wilson stated that ergonomists, instead of focussing on the traditional man, machine and environment component, should refocus on the interaction among these components. (Wilson, 1999). Nowhere is this truer than in the process of web design. Simply stated a web page is really a page, off the information highway, that has the information the User needs. The beauty of the Web is that, that information could be of any imaginable kind. In the last few years, the number of businesses establishing a presence on the World Wide Web (WWW, the web) has grown exponentially. It is just a matter of time before the web becomes a primary source of information for a large part of the world for all needs. Procedurally the steps in design include cognitive design, visual design, technical design, technical development and testing. Typically cross-functional teams are set up to perform the design process. Information ergonomics and interaction ergonomics are the main issues in the iterative design process. The importance of cognitive ergonomist who plays a pivotal role in the design process is discussed.


The 2016 WHO classification describes a specific subtype of midline gliomas harboring histone 3 (H3) K27M mutations which compromise 15–40% of gliomas in children and young adults. Since we began to perform molecular profiling at Memorial Sloan Kettering Cancer Center (MSKCC) we have observed an increased prevalence of leptomeningeal disease (LMD) in this population. However, the true incidence and the clinical behavior of this group has not been well-defined.

 This is a retrospective study of patients with H3K27M/I diffuse midline gliomas at MSKCC from 01/2012 to 01/2019. Mutations were identified through next-generation sequencing (NGS).

 We identified 24 patients. Median age was 21 (6–70) and 13 were male. Thirteen tumors were in the thalamus, 6 in the brainstem, 4 in the spinal cord, and 1 in the pineal region. H3K27M mutations were detected by NGS from tumor tissue in 21 patients, from cerebral spinal fluid (CSF) circulating tumor DNA (ctDNA) in 2 and from tissue and CSF ctDNA in one. LMD was diagnosed in 17/24 (71%) patients radiographically. Of these, 8 underwent LP: CSF cytology was positive in 2/8 and CSF ctDNA was detected in 3/3. All patients received RT and one or more lines of chemotherapy. At analysis, thirteen patients remain alive. Median time to last follow up for all patients was 14.2 months. Median time from diagnosis to LMD was 13.2 months (0–45.1), with median OS of 6.5 months (0.3–27) after diagnosis of LMD.

 Our study showed that more than two-thirds of the patients with H3 K27M diffuse midline developed LMD. Neuroaxis imaging should be performed in conjunction with CSF studies to diagnose LMD. Besides, CSF ctDNA represents an important tool to identify molecular profile of tumors when biopsy is not feasible or limited for the analysis.


The computation of autocorrelation matrix is used heavily in several areas including signal and image processing, where parallel and application-specific architectures are also being increasingly used. Therefore, an efficient scheme to compute autocorrelation matrix on parallel architectures has tremendous benefits. In this paper, a parallel algorithm for the computation of autocorrelation matrix on 2-D mesh, is presented. The computation requirements for the elements of the autocorrelation matrix is highly skewed and the proposed algorithm attempts to balance the computation load, without requiring an external load balancing algorithm or processor. In this sense, the load balancing is embedded within the algorithm. The exact number of computation steps are derived. The time complexity of the proposed algorithm is shown to be within twice the optimal (or lower bound). It is also shown to have twice the speedup of a straight-forward parallel algorithm.


The current debate about the balance between child protection and family support, informed by the publication of a sequence of government sponsored research studies, tends to focus on the investigative stage of child protection relating to Section 47 of the Children Act 1989 and contrasts this with the less stigmatising approach of assessment and support to the families of children in need under Section 17 of the Act. Little attention has so far been paid in Government documents and guidance to the child protection process after the initial investigative stage. The work of the core group, set up by the child protection conference when a child's name is placed on the register, is, however, the main vehicle for the implementation of the plan to protect the child(ren) at risk in a family and marries the twin strands of protection and support. Because of the pressures on training and staff development sections of Social Services Departments, as well as on academic institutions offering social work courses to ...


This study examines the difference in perception of a character in a male and a female guise amongst university students in Seychelles, and elaborates on how such difference reflects gender hierarc ...


A new formulation of the inner boundary problem for description complex nonequilibrium flows between membranes is presented. Solutions by means of the Boltzmann equation and the model kinetic equation for mixtures with chemical reactions demonstrate interesting physical properties in this open nonequilibrium system. Possibility of the anomalous thermal transport where the heat flux and the temperature gradient are of the same sign, is studied. Influence of boundary conditions on the parameters of the structure is considered as well.


1. Organ transplantation is now clinically routine for patients with end‐stage organ failure. One major limitation in transplantation is chronic rejection involving the loss of the graft despite the use of immunosuppressive agents. Haematopoietic stem cell (HSC) chimerism, achieved through bone marrow transplantation (BMT), induces donor‐specific tolerance to transplanted organs and prevents chronic rejection.


In order to provide substantially not containing heavy metals zinc chloride has an excellent resistance to embrittlement properties, a polyurethane yarn is particularly suited for use in swimwear and using the polyurethane yarn fabric, swimwear, characterized in that the formed part comprises a hindered phenol compound and a synthetic carbonate polyurethane yarn, wherein the partially hindered phenol compound having at least a partially hindered hydroxyphenyl group and a molecular weight of 300 or more, the synthetic carbonates comprising one metal selected from alkali metals and alkaline earth metals; and the polyurethane yarn mixed with other fibers, fabrics made, swimwear.


Various bisexual flowering plants evade the harmful effects of inbreeding by employing genetically controlled selfincompatibility (SI) mechanisms to ensure out crossing (Charlesworth and Charlesworth, 1987). SI mechanisms make available the biochemical machinery essential for plants to recognize and discard their own pollen as well as non-self pollen with a genotype amply similar to obtain activation of the SI mechanism. SI plays an important role in determining the spatial and temporal distribution of genetic diversity in plant populations and is thought to influence patterns of lineage diversification in clades within which these mechanisms are utilized (Igic et al., 2008). About 96 per cent of flowering plants produce perfect flowers that contain both the male and female reproductive organs in close proximity; accordingly, they would have a strong affinity to self-fertilize if there were no mechanisms to prevent them from doing so. Because inbreeding can result in reduced fitness in the Abstract : Self-incompatibility, is a genetically controlled mechanism for rejection of own pollen. It has been a favourite topic for botanists and geneticists since Darwin who first discussed this phenomenon and suggested its central significance during the evolution of flowering plants. Different genetic and mechanistic systems of SI among different plant families suggest either multiple origins of SI or considerable evolutionary diversification. Within the last two decades, molecular and biochemical analyses which have significantly contributed to the elucidation of the complex series of interactions occurring at the pollen-stigma interface. Molecular analyses of self incompatibility systems have focused on identifying and characterizing the pollen and pistil components of the self-incompatible response as well as other proteins and events that lead to pollen rejection. In this review, an attempt has been made to provide a comprehensive insight for the molecular dissection of this important mechanism for its utilization in crop improvement.


Molecular orbital theory at the INDO level of approximation is used to calculate the Fermi contact contribution to two-bond and three-bond nitrogen–proton coupling constants for a wide variety of compounds. The dependence of calculated N,H coupling constants upon the spatial orientation of the nitrogen lone-pair is examined for selected molecules. For both saturated and unsaturated compounds the calculated 2J(15N,H) is large and negative when the lone-pair is oriented cis to the proton, and is small and of either sign when the lone-pair lies trans to the proton. Calculated 3J(N,H) depends both on the orientation of the nitrogen lone-pair and on the HCCN dihedral angle. Computed 2J(N,H) and 3J(N,H) generally follow the experimentally known substituent and structural effects. It is suggested that observed phosphorus–proton coupling constants in tervalent phosphorus compounds are dependent on lone-pair orientation in a manner analogous to the corresponding nitrogen–proton coupling constants. The influence of...


In this paper we present the results of analytical and numerical studies into synchronization of a large number of optically coupled resonators with random detuning of eigenfrequencies. We consider the `nearest-neighbor' coupling model with allowance made for gain saturation. Assuming that the coupling coefficient has zero imaginary part, the problem of steady-state phase distribution over the aperture of the two-dimensional array reduces to the problem of temperature distribution in a 2-D medium at the presence of heat sources and coolers with random powers. It is shown that the steady-state phase distribution over the aperture has the domain-like form. Phases in adjacent domains differ by values of the order of (pi) . Combining the scheme with nearest-neighbor coupling and external signal injection, we can easily attain synchronous lasing from large arrays.


Most of the existing results were related to the impact of land storms on sediment, and few explained the impact of storms on sediment movement and its formation law from the mechanism. At present, the research on the impact of storm on sediment suspension on the North Bank of Longkou City in the south of Bohai Sea was not clear. Therefore, this study aimed to explore the formation and mechanism of storm on suspended sediment from the perspective of hydrodynamic characteristics and sediment distribution by monitoring the impact of storm on sediment suspension in the south of Bohai Sea. A storm with wind speeds of 4.5–13.5 m/s occurred in the coastal area of the north side of Longkou City located in Southern Bohai Sea in April, 2015. Suspended sediment samples were obtained using automatic samplers, and the results showed that the suspended sediment content was 7.8 mg/L under normal weather conditions, which reached 121.2 mg/L at the highest during the storm event. Waves and tides were synchronously observed by acoustic Doppler current meter. Wave height was more closely correlated with wind speed when the wind veered to north, and the maximum wave height was 243 cm. The reciprocating motion of the current at the sampling site was strong, with the maximum current speed of 43.8 cm/s and a water depth of 10 m. The results of laser analysis showed that the bottom sediments were composed of 92% sand and 8% silt, with a medium diameter of 0.102 mm. From the experimental observation and result analysis, it was known that the strong dynamic process during storm surge led to the movement of sediment surface and the resuspension of sediment.


As of January 2014, 26 states had chosen to expand Medicaid under the Affordable Care Act (ACA) to cover individuals with incomes up to 138% of the federal poverty level. In these states, Medicaid agencies are facing one of the largest implementation challenges in the program's history. We undertook a survey of high-ranking Medicaid officials in these states to assess their priorities, expectations, and programmatic decisions related to the coming expansion. The Medicaid expansion poses major challenges in the domains of enrollment, management of health care costs, and providing adequate access to services for beneficiaries. Previous research has documented that millions of individuals eligible for Medicaid are currently not enrolled and remain uninsured, suggesting that state outreach strategies may underpin the success or failure of the ACA's coverage expansion.


The purpose o f this research is to analyze whether the persuasiveness o f client preferences and audit experiences have effect toward the auditors judgem ent in evaluating audit evidences both partially and simultaneously Survey in this study is applied on 62 auditors who work at public accounting firm s in Bandung by using a multiple linier regression analysis. The result indicates that the persuasiveness o f client preferences and audit experiences have a significant positive effect to the auditor s judgem ent in evaluating audit evidences both partially and simultaneously. The future research is suggested to examine other variables, such as: task complexity, gender, and conflicting fe e with extended research subject. Beside that, the future research is suggested to develop an experimental method so that the respondent behavior differences fo r each task can appear clearly.


Objective—Increasing evidence suggests that chronic inflammation contributes to atherogenesis, and that acute inflammatory events cause plaque rupture, thrombosis, and myocardial infarction. The present studies examined how inflammatory factors, such as interferon-γ (IFNγ), cause increased sensitivity to apoptosis in vascular lesion cells. Methods and Results—Cells from the fibrous cap of human atherosclerotic lesions were sensitized by interferon-γ (IFNγ) to Fas-induced apoptosis, in a Bcl-XL reversible manner. Microarray profiling identified 72 INFγ-induced transcripts with potential relevance to apoptosis. Half could be excluded because they were induced by IRF-1 overexpression, which did not sensitize to apoptosis. IFNγ treatment strongly reduced Mcl-1, phospho-Bcl-2 (ser70), and phospho-Bcl-XL (ser62) protein levels. Candidate transcripts were modulated by siRNA, overexpression, or inhibitors to assess the effect on IFNγ-induced Fas sensitivity. Surprisingly, siRNA knockdown of PSMB8 (LMP7), an "immunoproteasome" component, reversed IFNγ-induced sensitivity to Fas ligation and prevented Fas/IFNγ-induced degradation of Mcl-1, but did not protect p-Bcl-2 or p-Bcl-XL. Proteasome inhibition markedly increased Mcl-1, p-Bcl-2, and p-Bcl-XL levels after IFNγ treatment. Conclusions—Although critical for antigen presentation, the immunoproteasome appears to be a key link between inflammatory factors and the control of vascular cell apoptosis and may thus be an important factor in plaque rupture and myocardial infarction.


The results of extreme dynamical analyses of the suspension system of the linear induction motor (LIM) test vehicles are presented. Suspension stiffness and damper rates are selected on the basis of computations of lateral dynamic stability, curving and response, which should enable the vehicle to travel at speeds up to 250 mph with satisfactory riding characteristics. The influence of variations in suspension parameters is also discussed in relation to possible experimental studies on high speed, wheel supported and guided vehicles, using the LIM vehicle.


AimTo optimize the preparation technique of Radix Arnebiae oil.MethodsThe optimum preparation technique of Radix Arnebiae oil was investigated by L_(8)(2~(7))orthogonal test as the acetylshikomin content index.ResultsThe optimum technical condition: Selected Arnebia euchroma(Royle)Johnst ,added 4 times peanut oil and cooked an hour ,monitored oil's temperature(150).ConclusionWith the optimized preparation technique,the content of acethylshikomin in compounded Radix Arnebiae oil can be effectively increased, and the preparation quality can be more stabilized.


I Brief Communication I AGED SEEKING PSYCHIATRIC HELP: AN EXPLORATORY STUDY INTO THE EFFECT ON CARE GIVERS K. Praveenlal S. Dube D. Mohan K.R. Sundaram. A hospital based explorative study on the aged seeking psychiatric help was conducted with the aim of assessing the effect on the care givers caused by the psychiatric illness of the patients. Attendants of 56 patients above the age of 60 years were studied. Patients showed troublesome behaviour (75%) needed excess care and attention ( 59%) anxiety (45%) and made allegations against atterzdents (32%) which resulted in experience of strain by attendants (73%).


To compare the thermogenic properties of crude drugs derived from ginger, the activities to peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) of methanol extracts of "Shokyo" (dried rhizome of Z. officinale var. rubens), "Kankyo" (steamed and dried rhizome of Z. officinale var. rubens), "Red ginger" (Indonesian dried rhizome of Z. officinale var. rubrum) and "White ginger" (Indonesian dried rhizome of Z. officinale var. amarum), were examined. The extracts of the four specimens were analyzed by liquid chromatography mass spectrometry (LC-MS). The results showed that "Shokyo" and "White ginger" strongly stimulated PGC-1α and that the amount of [10]-shogaol (6) in these was higher than in "Kankyo" and "Red ginger". Gingerol-related compounds were isolated or prepared in order to identify the compounds responsible for stimulating PGC-1α. As a result, [10]-gingerol (3), [10]-shogaol (6), [10]-gingerdiols (11, 12) and [10]-gingerdiols 3,5-diacetate (17, 18) were identified as the active constituents, while the main constituents, [6]-gingerol (1) and [6]-shogaol (4), did not show any significant PGC-1α activity. These results suggest that gingerol-related compounds with long alkyl side chains contribute to the thermogenic properties of ginger.


Recently, Brazil became the biggest soybean producer and exporter in the world. The state of Pará, located in the Brazilian amazon biome, became one of the last agricultural frontiers of the country, which positively increased the soybean cultivation along it is territory. However, it is necessary to know the associated environmental impacts along the supply chain. Thus, we are applying the life cycle assessment (LCA) methodology using openLCA software to two producing regions: northeast pole (Paragominas) and south pole (Redenção). Based on the cradle to grave scope, the Recipe Midpoint (H) and Intergovernmental Panel on Climate Change (IPCC) methods of the environmental impact categories were used. To calculate the land use change (LUC), we used the BRLUC regionalized model (v1.3). The obtained results showed that LUC was mainly responsible for the global warming potential (GWP) along all soybean supply chains, especially when land occupied with tropical forests was adapted for growing soybeans. Despite the largest distance between the origin and destiny (road + railway = 1306 km), the soybean produced in the south pole (Redenção) is better shipped through the TEGRAM port of São Luis–Maranhão due to the use of multimodal platforms (lorry + train), allowing for a more efficient logistical performance (greater loads of grains transported and less environmental impact). The soybean produced in northeast pole (Paragominas) is better shipped through the ports around Barcarena–Pará due to the short distance by road (average 350 km) and hence less environment impact.


The Journal of Sustainable Agriculture puts forth a special issue, entitled, "Agroecology and the Transformation of Agro-Food Systems: Transdisciplinary and Participatory Perspectives." This issue will examine recent trends in agroecology that view the field as a transdisciplinary and participatory process, which seeks to actively engage social actors to transform the global agro-food system. This agroecological perspective looks to analyze and engage actors and social processes at different geopolitical scales. Much of the work aligned with this approach is characterized by the use of transdisciplinary and participatory action research (PAR). The first can be defined as an approach that integrates, not only different academic disciplines (especially the social with the natural sciences), but also values and includes different forms of knowledge and practice (e.g., experiential, cultural, spiritual, etc.).The second is a way of engaging all relevant actors in an effort to attain an equitable process of research, reflection, and engagement on areas of desirable social change. Agroecology is defined as the integration of science, practice, and social movements in food systems. To truly be agroecology, this integration is a necessity.


PURPOSE
To calculate dose distributions from CyberKnife Image Guided Radiation Therapy (IGRT) for brain, H&N, lung, and pelvis treatment regions and use them to extract the corresponding effective dose and estimate related risk.

METHODS
We developed a CyberKnife IGRT kV beam model in a standard treatment planning system and validated it against measurements in heterogeneous phantoms. Five brain, five head and neck, five thorax, and ten (five male and five female) pelvis patient CTs were contoured. The dose distribution resulting from different CyberKnife IGRT protocols were calculated. From them, the effective dose was calculated according to ICRP publication Nr 103, using the average dose to contoured organs. The corresponding risk factors was calculated. Entrance surface dose (ESD) were also calculated and compared with existing data.

RESULTS
The maximum effective dose produced by CyberKnife IGRT protocols was 0.8 mSv (brain), 1.9 mSv (H&N), 20.2 (pelvis), and 42.4 mSv (thorax) per fraction for a risk estimate of 0.004% (brain), 0.01% (H&N), 0.1% (pelvis), and 0.2% (thorax). Calculated ESD were compatible with existing data.

CONCLUSIONS
Dose calculation models for CyberKnife IGRT kV beams were implemented in a clinical treatment planning system and validated in water and heterogeneous phantoms. We determined the effective dose and the related risk estimate resulting from CyberKnife IGRT protocols for brain, head and neck, thorax, and pelvis cases. The effective doses calculated for CyberKnife IGRT protocols were similar to those obtained for Cone Beam CT protocols on conventional C-arm linear accelerators, except for extreme irradiation conditions for thorax cases (140 kV X-ray tube tension).


Phosducin‐like protein 1 (PhLP1) was recently shown to be a co‐chaperone with the cytosolic chaperonin complex (CCT) in the folding and assembly of nascent G protein βγ dimers and Gβ5‐RGS proteins. However, other possible functions of PhLP1 warrant investigation. A co‐immunoprecipitation proteomics screen indicated PhLP1 interacts with a known tumor suppressor, programmed cell death 5 protein (PDCD5), which is implicated in apoptosis. Subsequent experiments showed PDCD5 associates with PhLP1 indirectly via a ternary complex with CCT and had no effect on PhLP1‐mediated Gβγ assembly. Previous studies suggested that PDCD5 translocates rapidly from the cytoplasm to the nucleus during the initial stages of apoptosis. However, our results indicate that PDCD5 is exclusively cytosolic in both resting and apoptotic cells, thus its apoptotic function is also cytosolic. Co‐immunoprecipitation proteomics screens show that PDCD5 interacts strongly with CCT and β‐tubulin. Cryo‐EM studies show a complex of PDCD5 and CCT, interacting at one of the apical domains. Moreover, biochemical analyses suggest that PDCD5 phosphorylation increases its binding to CCT during apoptosis and when bound to CCT, PDCD5 blocks β‐tubulin folding. We propose that PDCD5 binds to the apical domain of CCT as a co‐chaperone or inhibitor of CCT substrates involved in cell cycle progression or apoptosis. This research was funded by an NIH grant.


Reproducibility is a central aspect of offline as well as online evaluations, to validate the results of different teams and in different experimental setups. However, often it is difficult or not even possible to reproduce an online evaluation, as solely a few data providers give access to their system, and if they do, it is limited in time and typically only during an official challenge. To alleviate the situation, we propose STELLA: a living lab infrastructure with consistent access to a data provider's system, which can be used to train and evaluate searchand recommender algorithms. In this position paper, we align STELLA's architecture to the PRIMAD model and its six different components specifying reproducibility in online evaluations and illustrate two use cases with two academic search systems.


The invention belongs to the field of medical instruments, and particularly relates to a condom with antisepsis and anti-inflammation functions. A lubricant of the condom contains sophocarpidine, and the condom is subjected to plasma treatment before being coated with the lubricant. Under the condition of not changing the original production, detection and package technological process, sophocarpidine is applied to the lubricant of the condom, and therefore, the condom can be used for prevention and auxiliary treatment of such gynecological diseases as cervical erosion, leukorrhea with reddish discharge, trichomonas vaginitis and vaginal fungal infection.


This article discusses the importance of functional grammar and demonstrates its application to the teaching of reading among graded college students. Functional grammar holds that a discourse is composed of two levels: the interior level and the exterior level. Therefore, reading activities involve both linguistic elements and contexts. Implications of functional-grammatical view of reading are discussed, with techniques suggested for teaching of reading to English learners in the beginning and advanced proficiency levels.


State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou 310058, China (C.W., W.Y., Y.Y., S.W., Y.L., H.S.); Australian Research Council Centre of Excellence in Plant Energy Biology, Department of Plant Science, School of Agriculture Food and Wine, University of Adelaide, Glen Osmond, South Australia 5064, Australia (C.W., S.D.T.); Australian Research Council Centre of Excellence in Plant Energy Biology, University of Western Australia, Perth, Western Australia 6009, Australia (D.S.); and Department of Animal, Plant, and Soil Science, Australian Research Council Centre of Excellence in Plant Energy Biology, School of Life Science, La Trobe University, Victoria 3086, Australia (J.W.)


This contribution reports the results of an investigation on the speciation of various lanthanoid(III) cations (Ln3+), namely, La3+, Nd3+, Sm3+, Eu3+, Gd3+, Dy3+, and Yb3+, in the presence of reduced glutathione (or simply glutathione, GSH), in NaCl(aq) at I = 0.15 mol·dm–3 and T = 298.15 K. GSH forms in all cases the same four species, namely, Ln(GSH)H3, Ln(GSH)H2, Ln(GSH)H, and Ln(GSH)OH, whose stability depends on the type of lanthanoid, although it is also possible to consider an average stability for a generic lanthanoid, at least for the protonated species. Measurements at different temperatures and ionic strengths for the La3+/GSH and Gd3+/GSH systems have also been performed, to evaluate their effect on the speciation of both GSH and the Ln3+ cations. The dependence of the determined stability constants on I and T has been modeled by an extended Debye–Huckel type and by the van't Hoff equations. In this last case, the formation enthalpy changes of La3+/GSH species have also been determined. The st...


Background: The development of social economy not only provides jobs for the employed, but also brings many challenges. Among them, higher vocational college students, as the main employment group, how to choose the employment direction is the key guidance content needed by the school. In the employment guidance of higher vocational colleges, the main content emphasized by the college is to meet the employment needs of students, the second is to meet the professional needs of students. Although this employment guidance method has improved the overall employment rate of students, it is undeniable that a large number of students will not adapt to psychology after employment, and even choose to reemploy. The main reason is that the existing employment guidance in higher vocational colleges is lack of systematicness and pertinence, and the teacher team participating in the guidance is unreasonable. In order to avoid the students ' employment problems caused by the above problems, a large number of colleges and universities began to apply educational psychology to employment guidance and build a new path by using the basic theory of educational psychology.


This paper introduces two pulse coding control methods for generating notch frequency automatically in noise spread spectrum for switching DC-DC converters; these are based on our previously proposed method. Our two methods here generate the notch frequency Fn automatically according to the received frequency Fin. The first one is a constant frequency PWM-controlled buck DC-DC converter where the clock frequency and coding pulse width are automatically set according to the frequency of the received signal to generate notch characteristics. The second one is a pulse frequency modulation (PFM) pulse coding DC-DC converter which generates a composite notch characteristic where both the constant pulse width and the periodic modulation coding pulse width are automatically matched with input frequency Fin. Our simulation results show that the transient response is fast and the output voltage overshoot is small.


We propose a hybrid quantum-classical algorithm, originated from quantum chemistry, to price European and Asian options in the Black-Scholes model. Our approach is based on the equivalence between the pricing partial differential equation and the Schrodinger equation in imaginary time. We devise a strategy to build a shallow quantum circuit approximation to this equation, only requiring few qubits. This constitutes a promising candidate for the application of Quantum Computing techniques (with large number of qubits affected by noise) in Quantitative Finance.


Economic integration can assume many forms (Testas (1996, 1997)). The most advanced of these have occurred in Customs Unions (CUs) and Free Trade Areas (FTAs) such as the European Union (EU), North American Free Trade Agreement (NAFTA) and Australia-New Zealand Closer Economic Relations Trade Agreement (ANZCERTA). Similarly, the Association of South-East Asian Nations (ASEAN) and the North African Arab Maghreb Union (AMU) are now evolving into more comprehensive regional trading arrangements. Since this study is aimed to focus on these two integration schemes, a brief background on their formation is needed before any empirical analysis is made. First, ASEAN comprising the original five (Malaysia, Singapore, Thailand, Indonesia and the Philippines) has an explicit timetable for eliminating tariffs within the group by the year 2003 and introducing its Common Effective Preferential Tariff (CEPT) (see Asian Development Outlook (1996)). The CEPT was formerly restricted to manufactured and processed agricultural products; but at the ASEAN economic Ministers meetings in September 1994 and April 1995, a number of measures were taken to reduce exclusions and extend the commodity coverage to services and to accelerate the timetable. Under the Framework Agreement on enhancing ASEAN economic integration, the member states have agreed to eliminate quantitative restrictions and non-tariff barriers on trade in products in the CEPT and to co-operate in some areas of service trade. The member states have also agreed to explore co-operation regarding some non-border measures, including harmonisation of standards, reciprocal recognition of tests and certification of products, and removal of barriers to foreign investments.


Two distinct boron-related centers are known in silicon carbide polytypes, one shallow (ionization energy ∼300 meV) and the other deep (∼650 meV). In this work, 4H SiC homoepitaxial films are intentionally doped with the shallow boron center by controlling the silicon to carbon source gas ratio during chemical vapor deposition, based on site competition epitaxy. The dominance of the shallow boron center for samples grown with a low Si/C ratio, favoring the incorporation of boron onto the silicon sublattice, is verified by the temperature dependent Hall effect, admittance spectroscopy and deep level transient spectroscopy. In these samples a peak near 3838 A appears in the low temperature photoluminescence spectrum. Further experiments support the identification of this peak with the recombination of a four particle (bound exciton) complex associated with the neutral shallow boron acceptor as follows: (1) The intensity of the 3838 A peak grows with added boron. (2) Momentum conserving phonon replicas are o...


The use of an oil extracted from seeds of the borignaceae family in topical application to, or oral ingestion by, the human or animal body. This oil alone may be used for these purposes, or, preferably, it is used to form a part of a composition for topical application to, or oral ingestion by, the human or animal body.


In the opening essay of his 1992 collection, The Order of Books, Roger Chartier drew attention to the way that studies of the histoire du livre might fail to give an adequate account of the cultural function of early modern books by ignoring two interrelated aspects of the act of reading itself: first, that reading is an embodied practice and second, that it is a social one. Chartier recalled that 'Reading is not uniquely an abstract operation of the intellect: it brings the body into play, it is inscribed in a space and a relationship with oneself and with others', going on to propose that 'special attention should be paid' to one crucial aspect of early modern reading practice that has largely disappeared in the contemporary world – 'reading aloud'.
[Quotations from Roger Chartier, The Order of Books: Readers, Authors and Libraries in Europe between the Fourteenth and Eighteenth Centuries, trans. Lydia G. Cochrane (Stanford, CA: Stanford University Press, 1994), p. 8; originally published as L'ordre des livres (Aix-en-Provence: Alinea, 1992).]


Background: the occurrences of diabetes mellitus and diabetic nephropathy have increased quickly in the past few decades and have become an economic burden to the healthcare system in KSA. Diabetic nephropathy is a major complication of diabetes mellitus and is a primary cause of end-stage renal disease (ESRD). The occurrence of non-diabetic renal disease (NDRD) in diabetic patients has been increasingly recognized in recent years. It is generally believed that it is difficult to reverse diabetic nephropathy, whereas some cases of non-diabetic renal disease are readily treatable and remittable. However, diabetic nephropathy is known to co-exist with non-diabetic renal disease in a poorly defined population of patients with type 2 diabetes mellitus. This study estimated the pervasiveness of co-existing diabetic nephropathy and non-diabetic renal disease in Saudi patients.
 Methods:data were retrospectively analyzed from 122 patients with type 2 diabetes mellitus who had experienced a renal biopsy between February 2014 and June 2017  at King Abdulaziz Hospital, region(s), KSA. Male patients numbered 75 (61.5%) of the study population. The biopsies were performed as urinary abnormalities or renal functions were atypical of a diagnosis of diabetic nephropathy. Biopsy samples were examined using light, immunofluorescence (IF) and electron microscopy (EM). Clinical parameters were recorded for each patient at the time of biopsy.
 Results: nineteen of 122 diabetic patients (8%) had co-existing diabetic nephropathy and non-diabetic renal disease. These patients showed clinical features and pathologic characteristics of diabetic nephropathy, containing a high prevalence of diabetic retinopathy (88.8%), a long duration of diabetes, increased thickness of the glomerular basement membrane (GBM) and mesangial expansion. Nonetheless, they similarly presented with clinical findings which were inconsistent with diabetic nephropathy, such as hematuria, rapidly progressive renal failure and marked proteinuria. Immunoglobulin A (IgA) nephropathy was apparent in 5 out of the 10 patients (50%), tubulointerstitial lesions were found in two patients (20%), membrano-proliferative glomerulonephritis (MPGN) in two patients (20%) and membranous nephropathy (MN) in one patients (10%).
 Conclusion: retrospective analysis of biopsy data suggests that approximately 8% of Saudi patients with type 2 diabetes mellitus may have co-existing diabetic nephropathy and non-diabetic renal disease. The most common histological diagnosis in our small series was IgA nephropathy.


10.1 INTRODUCTION Chalcogenide glasses (ChGs) are well known for their high infrared (IR) transparency and amenability to fabrication in fiber and thin film forms, which makes them attractive candidates for mid-IR optical chemical and biological sensors. This chapter describes recent advances in the production of sensing devices from a variety of thin film and fiber structures, highlighting the critical materials parameters needed for achieving low loss, high detectivity operation. Because the sensitivity of chemical sensors in thin-film and fiber form is typically directly related to some physical characteristic, such as optical path length, which is much higher in these low-dimension structures than that of the associated bulk glass optics, the physical form of the sensor ultimately dictates or influences the required material properties such as optical loss, viscosity, or coefficient of thermal expansion. Sections 10.2 and 10.3 will review the functionality of ChGs in thin film and fiber sensing applications, with a focus on how this functionality is impacted by the choice of ChG constituents. The strengths and drawbacks of these sensing approaches will be discussed, as some ChG compositions are well-known for limited chemical and temperature stability, as well as high photosensitivity, which can make them excellent candidate material systems for use in some sensing regimes and environments, but preclude their use in other applications. Having outlined the required material characteristics necessary for these sensing applications, the discussion in Section 10.4 will then turn to compositional design approaches used to obtain these characteristics using multi-component ChGs. Varying elemental compositions can be used to tailor glass optical and thermal properties to meet design challenges; however these properties are tightly correlated and so the problem becomes one of global, rather than individual, optimization in the parameter space of interest. This chapter concludes with a brief discussion of the conclusions of the present review, as well as the future directions the authors see this exciting field expanding to include.


The influence of classic and rapid thermal annealing pretreatments under nitrogen or hydrogenated ambients on thermal donor formation and on the further oxygen nucleation step were studied. A rapid thermal annealing at 1200 o C under a nitrogen ambient delayed the formation of thermal donors. If nitrogen was replaced by a hydrogenated ambient, thermal donor formation was largely enhanced. In each case further nucleation was affected. A modification of the precipitation path due to rapid thermal annealing is proposed to be at the origin of the tremendous effect of a prior lamp anneal on the internal gettering process. The classic heterogeneous nucleation of the platelets would be prevented and the precipitation would proceed through a homogeneous path leading to precipitates unable to getter metal impurities


The notion of bisimulation is extended to Game Logic (GL), a logic for reasoning about winning strategies in 2-player games. We show that all game constructions of GL are safe for bisimulation, i.e. that an atomic bisimulation can be lifted to non-atomic games constructed by the operations of GL. As a consequence, bisimilar states satisfy the same GL-formulas.


An experimental study of simultaneous XEDS and EELS measurements using both conventional beryllium window and windowless Si(Li) detector systems together with a magnetic sector electron loss spectrometer was conducted on a series of metal alloys, oxides and ceramic compounds covering the elemental range of Li through Ga, with the exception of the gases Neon and Argon, as well as a few typical steel alloys. The advantages and disadvantages of the different systems XEDS versus EELS are outlined relative to the materials problems to which they can be applied.


A unique costorage of neuropeptides was recently found in the abdominal perisympathetic organs (PSOs) of the American cockroach, Periplaneta americana. Having specific antisera directed against all peptides belonging to this neurosecretory system, we examined the sorting of PSO‐peptides in the soma of the median neurosecretory cells of abdominal ganglia by using immunoelectron microscopic double stainings. The data indicate that all six abundant neuropeptides of this neurohormonal system, which includes three capa‐gene related products, are primarily incorporated into separate vesicles. These vesicles fuse with each other in the cytoplasm and become translucent on their way to the axon hillock. By means of light microscopy and MALDI‐TOF mass spectrometry, an identical population of neuropeptides was found in interneurons of the brain. As revealed by subsequent immunoelectron microscopic analysis, the peptides of these cells are separately packed into dense core vesicles but do not fuse with each other. Thus, hitherto unknown cell‐type–specific sorting mechanisms occur in neurosecretory cells and interneurons, respectively. J. Comp. Neurol. 481:84–95, 2005. © 2004 Wiley‐Liss, Inc.


Color changes in conodonts are established thermal indices that have been related to the thermal window for hydrocarbon generation and preservation and that also have value for targeting mineralization potential. Conodont color-alteration values from 141 localities in Arizona appear to characterize the thermal maturation of the major Paleozoic outcrop areas in the state. Paleozoic rocks in the Colorado Plateau, in part of the belt of faulted plateau-like rocks bordering the plateau, and in a small area (from 31°20^prime to 31°44^primeN and from 110°00^prime to 110°40^primeW) in southeast Arizona have thermal potential for oil. Paleozoic rocks in the same areas as well as in the Pedregosa basin (southeasternmost Arizona) have thermal potential for gas. f these areas, southeast Arizona appears to have the best hydrocarbon potential because of the association of possible source beds and favorable thermal-maturation levels.


We present a new design of a low-temperature ultrahigh-vacuum (UHV) scanning tunneling microscope setup with a combination of a solenoid and a split-pair magnet. The scanning tunneling microscope can be operated at temperatures down to 8 K and in a rotatable magnetic field of up to 1 T. Magnetic fields of up to 7 T perpendicular and 2 T parallel to the sample surface can be applied. The UHV part of the system allows in situ preparation and low energy electron diffraction/Auger analysis of samples. First topographic and spectroscopic measurements on p-InAs(110) are presented.


The transformations caused to the environment due to anthropic activity, have been modifying the population dynamics of vector insects over the years. Frequently, insects that have typically wild habits have adapted to breeding sites located in urban areas and, consequently, to coexistence with humans. The goal of this study was to analyze Haemagogus fauna in different areas of Atlantic Forest fragments in the State of Rio de Janeiro, in order to associate mosquito density, climatic variables and vegetation conditions, thus assessing the risk of transmission and emergence of arboviruses. Mosquito capturing was carried out through the use of CO2 traps and ovitraps for egg capture. After capture, the eggs were submitted to 40 immersions, to test the hatching rate and to evaluate the immersion with the highest eclotibility throughout the study period, which were the 3rd and 22nd immersion for both Hg. leucocelaenus and Hg. janthinomys. The specific determination of the adult culicide was done by direct observation of the morphological characters. Morphometric analysis was performed on the wings for the differentiation of Haemagogus capricornii and Haemagogus janthinomys The wings were mounted between slide and coverslip, photos were taken with the aid of the stethoscope microscope, based on these photos, fourteen points of the wing were used to perform the analyzes. Coordinate data, isometric estimator and centroid size (CS), were used to compare the overall size of the wings among the species, in which the CS of Hg. capricornii was significantly lower (P <0.0001) than that of Hg. janthinomys. To evaluate the influence of climatic variables (precipitation, maximum dew point and direction), canonical correspondence analysis (CCA) was used, it was possible to observe that Hg. janthinomys was positively correlated with the three climatic variables, while Hg. leucocelaenus presented a positive correlation with precipitation and maximum dew point, and was negatively correlated with direction. This study aimed to enrich biodiversity knowledge of potential and known Wild Type Yellow Fever Culicidae vectors, in the studied areas (Pocos das Antas Biological Reserve, Bom Retiro Private Reserve and Sana Environmental Protection Area), which will not only allow a better understanding of these vectors\2019 population dynamics, but also make it possible to assess new risk situations for the transmission of this arbovirose in the city of Rio de Janeiro.


The aim of this paper is to identify and clarify the elements and possible role of psychological ownership in highly skilled employees' retention. The methodology encompasses a qualitative research design. Data were analysed through thematic analysis and compared with the theoretical elements of psychological ownership. The findings indicate that highly skilled employees identify with the elements of psychological ownership. Contextual factors, especially structural aspects, including clear communication, relationship building, clear direction and goal alignment, ethical conduct, recognition and acknowledgement and leadership, surfaced more explicitly as requisites for talent retention.


NEW ADVERTISEMENTS TBit WEEK. ! Cordelia Watt—Petition for divorce. Frank FI tie— Notice of foreclosure. Commissioners of inland fisheries and game —Notice. Exec notice—Eat Anthony Howard Hinkle, i Probate notice—Eat Grace R Shaw. ** —Eat Lewis F Gray et ala. Leonard C Hodgklns-Cantlbn notice. Registration of voters. Exec notice—Bet Moses E Friend, i. Adnar notice—Bat Cyntha P Smith, New England Tel A Tel Co. H M Bellatty—Card and stationery store. I Baiioon, Mn: Eastern Trust A Banking Co. I Do# basinets college. Boston: A B Pendleton—Cottage for exchange.


this conceptualization has an undeniable value for the academic exploration of contemporary communication and the ethico-political debates over censorship and regulation. It also speaks beyond academia to engage with competing needs and entitlements in contemporary life and in doing so fosters a deeper understanding, not only of our own right to be heard but of the communicative needs of others.


This paper analyzes the relationship between two representative statistical methods for bandwidth extension (BWE): Gaussian Mixture Model (GMM) and Hidden Markov Model (HMM) ones, and compares their performances. The HMM method is a memory-based system which was developed to take advantage of the inter-frame dependency of speech signals. Therefore, it could be expected to estimate better the transitional information of the original spectra from frame to frame. To verify it, a dynamic measure that is an approximation of the 1st-order derivative of spectral function over time was introduced in addition to a static measure. The comparison result shows that the two methods are similar in the static measure, while, in the dynamic measure, the HMM method outperforms explicitly the GMM one. Moreover, this difference increases in proportion to the number of states of HMM model. This indicates that the HMM method would be more appropriate at least for the 'blind BWE' problem. On the other hand, nevertheless, the GMM method could be treated as a preferable alternative of the HMM one in some applications where the static performance and algorithm complexity are critical.


ABSTRACT The present study is the first study undertaken in Australia that seeks to explore practitioners' perspectives on the use of clinical supervision in their therapeutic engagement with asylum seekers and refugees. We used thematic analysis to analyse extracts of interviews that were conducted with nine professionals who worked therapeutically with asylum seekers and refugees and had experience of participating in individual and peer supervision. The findings of the study suggest that supervision encouraged practitioners to develop multicultural awareness and explore therapeutic ways of working that are compatible with their clients' frame. In addition, supervision provided the context in which practitioners explored the impact of the asylum legislative framework on their clinical work and reflected upon their feelings of powerlessness and political impotence. Implications for practice that derive from supervisory needs of practitioners who work with asylum seekers and refugees are explored.


shown that treatment with ETV or TDF may lead to regression of liver fibrosis, reduction of liver-related outcomes and mortality [8–10]. RESISTANCE: Both ETV and TDF have a high barrier to virological resistance, which is important for the longterm efficacy of these drugs. Long-term follow-up data of NA-na€ıve patients showed 1.2% of virological resistance to ETV after 5 years of treatment [3]. An observational study of NA-na€ıve and NA-experienced patients found an ETV resistance rate of 5% during a median follow-up of 20 months [8]. In patients with prior lamivudine resistance the risk of cross-resistance with ETV is considerable. It is recommended to switch to or add TDF [11]. For TDF, no resistance has been seen after 5 years of treatment [9]. SAFETY: There is limited information regarding the longterm safety of ETV and TDF. In general, both drugs are well tolerated with few side effects. Nucleotide analogues (e.g., TDF) may be more nephrotoxic compared to nucleoside analogues (e.g., ETV) [12]. It is recommended to monitor the renal function with serum creatinine and serum phosphate levels in patients treated with TDF [11]. CONCLUSIONS: ETV and TDF are potent drugs for suppression of the HBV which seems to reduce adverse clinical outcomes. The drugs have a high barrier to resistance and a good safety profile.


Background: Colorectal cancer remains a notable source of mortality and morbidity across the globe. It is the second commonest cancer in Malaysia. Robust screening program has exponentiated worldwide in last few decade especially in the western countries. Interestingly, there are more worrying reports of late to show that the incidence in younger patients, below 50 years of age are increasing. Aim: This study is aimed to look at clinical characteristics and survival outcome of this group in our local context. Methods: The National Colorectal Cancer Registry, The Northern Report 2008 - 2014 was reviewed retrospectively into the data to determine the number and clinical characteristics in patients with colorectal cancer in patients aged below 50 and in patients of 50 years and above. Results: A total of 3117 patients were included in the registry. 477 patients were younger than 50 years of age. Majority of the patients with colorectal cancer in the registry were from the Chinese ethnic group (59%), followed by the Malays (35%), Indian (5%) and others (1%). However, the younger patients' cohort seem to have more Malays diagnosed (54%), followed by the Chinese (36%), Indian (9%) and others (1%). Only 11% of the younger adults have family history of colorectal cancer. 68.1% of these patients, falls into the 40-49 age group. Sadly, majority of them (69.4%) are already in stage III or stage IV on presentation. The survival rate at 5 years however are significantly better in the younger patients with 45.49% as compared with the older group with 37.42% ( P = 0.015). Conclusion: Patients below 50 years with colorectal cancer presents with a different clinical characteristic as compared with the older patients. A review on a bigger national registry would be beneficial. Perhaps advocating a surveillance screening program for populations at an earlier age may be warranted in the future.


We demonstrate the value of collecting semantic parse labels for knowledge base question answering. In particular, (1) unlike previous studies on small-scale datasets, we show that learning from labeled semantic parses significantly improves overall performance, resulting in absolute 5 point gain compared to learning from answers, (2) we show that with an appropriate user interface, one can obtain semantic parses with high accuracy and at a cost comparable or lower than obtaining just answers, and (3) we have created and shared the largest semantic-parse labeled dataset to date in order to advance research in question answering.


The therapeutic algorithm for symptomatic Morton's syndrome is not standardized as several managements have been proposed. Ultrasound-guided alcohol injection (USGAI) is one of the non-operative procedures described. This report presents the case of digital ischemia that occurred after alcoholization for the treatment of Morton's syndrome. This complication is described for the first time in the scientific literature, and it should not only be added to the list of sequalae of USGAI, but more importantly, it should also be explained to the patient when this alternative treatment to traditional surgery is proposed.


The invention relates to a method for mounting the frame of a door on self-tapping screws, screwed into the side of a wall opening, using metal mounting plates screwed to said frame, and a mounting plate and a self-tapping screw for the implementation of said method. The invention makes it possible to mount a door in a low wall opening and to adjust the position of the frame in the opening and the position of the door ledge because the plates can be moved along the frame as a result of the shape of the fastening holes in the mounting plates. The presence of an additional head, for example in the form of a nut on the self-tapped screw that is screwed into the wall, makes it possible to adjust the gap between the leaf of the mounted door and the frame irrespective of the shape of the mounting plate.


An invented frequency multiplexing technique is used to combine inverted-F antennas for multi-band UWB. The frequency multiplexing technique allows a number of independent antennas to be used in parallel. In this paper a radio front-end system consisting of three antennas and a frequency multiplexing network is built. Using one antenna for each sub-band within a band-group provides equal performance for the entire band. Both the antennas and the frequency multiplexing network can be integrated on a printed circuit board. The antennas were simulated and measured. S-parameters of the antennas were extracted and used for co-simulation with the frequency multiplexing network. The antenna system fulfills the requirement for Mode 1 UWB.


In September 2011, Pakinam Amer of the Egypt Today Magazine reported that 'Before the revolution, Twitter had around 100,000 subscribers from Egypt. Shortly after, the figure jumped to 1.1 million, according to rough estimates released by internet experts in Egypt. Compared to 80 million [total population]...'


ABSTRACT As the American opioid epidemic continues to spiral out of control and our medical model remains unable to reverse the staggering trends, this article seeks to broaden clinician understanding of adolescents with substance use disorders by discussing adverse causative social–psychological dynamics: the marginalization of today's youth, decline of institutions of community and faith, and the burden of childhood trauma. The article then offers a holistic, multilevel model of substance use disorder treatment that recognizes and remediates these adverse dynamics in order to improve treatment outcomes and enhance clinician resilience.


A method of far-infrared generation by optical difference-frequency mixing between the modes of a mode-locked laser has been studied both theoretically and experimentally. General formulae for the spectrum and the intensity of the beat radiation for both mode-locked and non-mode-locked inputs were derived. The generation of a broad-band far-infrared beat in the range of 1–20 cm-1 was observed when the output of a mode-locked Nd:glass laser was incident on LiNbO3, ZnTe, ZnSe, CdS and quartz crystals without collinear phase matching conditions. The efficiency of beat generation was found to be enhanced by a factor of 10 due to mode-locking. The beat intensity and its anisotropy were measured for each crystal and were found to be in reasonable agreement with the theory. By using metal-mesh filters, a major portion of the beat energy was found to exist in the spectral region above 10 cm-1. The possibility of this scheme as a tunable submillimeter-wave source is discussed.


Protease Inhibitors are the new class of anti-HIV agent. Protease Inhibitors, e.g. Atazanavir, important constituents of the Highly Active Antiretroviral Therapy regimen, have dramatically impacted outcome of HIV treatment. In this research study, the Solid Lipid Nanoparticles of Protease Inhibitor, Atazanavir was characterized by entrapment efficacy, drug loading, particle size, zeta potential and drug release.


Copyright © 2021 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http:// creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  Evaluating APACHE II and APACHE IV Scoring Systems in Predicting Mortality Rate and Length of Hospital Stay in Patients with Head Trauma Mastaneh Rahmdel Tajan Gouce1, Atefeh Ghanbari 2*, Tahereh Khaleghdoost Mohammadi3, Ehsan Kazemnejad Leili4, Sadra Ashrafi5


In this study, CE-LIF with 405 nm laser diode was used to study
AHP5 fused with GFP. AHP5-GFP fusion proteins overexpressed in
E. coli were used for initial optimization of CE-LIF technique
because of lower concentrations of the fusion protein produced
by plant. The stability of the AHP5-GFP sample was examined;
the complex was found to be unstable with GFP being released.
The GFP release was not affected by either a long-term storage
at -80 and -20 C or the addition of one of the inhibitors
(EDTA, PMSF). These results were confirmed by the western
blotting. The phosphorylation of the sample AHP5-GFP in vitro
is under investigation. Gel filtration was used to obtain mass
fractions for better understanding electrophoregrams. The mass
fractions were investigated by CE-LIF and Western blotting-LIF
and Western blotting.


For evolution equations which can be written in Hamiltonian form two ways, there exists a relation between two functions Q(1) and Q(2), both of which are gradients of conserved functionals. The relation can be extended to define (recursively) functions Q(n). It is shown that the Q(n) corresponding to the general evolution equation associated with the Zakharov–Shabat eigenvalue problem are all gradients of conserved functionals. This in turn implies all these functionals are in involution.


Since pathogens resistant against vancomycin occur rapidly, the development of a new drug is needed. To make a new drug based on a rational drug design, the structural study of vancomycin is necessary. Accordingly, this study reports on a comparison of the solution structure of vancomycin determined by NMR spectroscopy, which was performed in the present work, with the X-ray crystallographic structure previously deposited in the Protein Data Bank (PDB).


Ecology, geographical and spatial distribution of Saccharina dentigera in the waters of East Kamchatka was analyzed. Results of studying the growth and seasonal dynamics of the average length and weight of Saccharina dentigera laminas and petioles in the Avacha Bay were discussed. It was demonstrated that the algae gained the maximal average length and weight for the third year of life. Mentioned species typically demonstrated single well-expressed peak of length and weight growth in August and spore formation concentrated in time wit a single peak of mass emergence of zoospores in late autumn.


A Lochkovian (Early Devonian) ophiuroid (Echinodermata), Ophiocantabria elegans n. gen. and sp., is based on a single small, well-preserved specimen collected from a shale-rich horizon of the Furada Formation, Asturias, Spain. Sedimentologic and palaeontologic data suggest its occurrence was in a near-shore setting subjected to frequent storms. Ophiocantabria is assigned to the Encrinasteridae based on the morphology of individual skeletal elements, although overall form of the new species is similar to that of approximately coeval members of the asteroid family Xenasteridae. Such homoplasy, especially among earlier members of asterozoan class-level clades, is an important but not well understood aspect of subphylum evolution.


Text Mining has become an important research area. Text Mining is the discovery by computer of new, previously unknown information, by automatically extracting information from different written resources. In this paper, a Survey of Text Mining techniques and applications have been s presented.


Proteasome inhibitors such as Bortezomib, represent an established type of targeted treatment for several types of hematological malignancies, including multiple myeloma, Waldenstrom's macroglobulinemia and mantle cell lymphoma, based on the cancer cell's susceptibility upon impairment of the proteasome-ubiquitin system. However, a major problem limiting their efficacy is the emergence of resistance. Their application on solid tumors is currently being studied, while simultaneously, a wide spectrum of hematological cancers, such as Myelodysplastic Syndromes show minimal or no response to Bortezomib treatment. In this study, we utilize the prostate cancer cell line DU-145 to establish a model of Bortezomib resistance, studying the underlying mechanisms. Evaluating the resulting resistant cell line, we observed restoration of proteasome chymotrypsin-like activity, regardless of drug presence, an induction of pro-survival pathways, and the substitution of the Ubiquitin-Proteasome System role in proteostasis by induction of autophagy. Finally, an estimation of the oxidative condition of the cells, indicated that the resistant clones reduce the generation of reactive oxygen species induced by Bortezomib, to levels even lower than those induced in non-resistant cells. Our findings elucidate key proteins of survival and stress regulation pathways as potential pharmaceutical targets, which could increase the efficiency of the proteasome-targeting therapies, thus expanding the group of molecular targets for neoplastic disorders.


This study aims to design a prototype of a microcontroller and arduino-based baby swing control system that will be very useful for housewives who have babies. This system will automatically work to move the swing when the sound of a baby and water is detected. This system is designed using a sound sensor that functions to detect the baby's voice, a water sensor to detect water when a baby is urinating, a DC motor that functions to move the swing automatically and a mobile application that functions to monitor swings. The test results show that the tool functions as desired, where when the tool detects the sound of a baby's cry, the tool automatically moves the swing, when the tool detects the presence of water, the swing will send a notification to the smartphone, this tool also successfully displays information to the smartphone in the form of a state baby in the form of video and sensor conditions on the swing. The communication distance between the smartphone and the device is 20 meters.


One studies the possibility of evaluating the local values of a multivalued function by means of a specific type of algorithm called multivalued decision algorithm. The reason for this choice is its wide range of applications that encompasses both hardware and software problems. Possible applications of the multivalued decision algorithm are: combinatorial synthesis of discrete functions by means of multiplexers, sequential synthesis of discrete functions using multivalued ROM's and multiplexers, transformation and optimization of microprograms.


This chapter concerns claims to the religious in federal Indian law as part of broader claims made in the register of sovereignty. It follows a number of crucial cases that concerned the shape of treaty-protected rights to fishing, hunting, and gathering off-reservation, notably those in the Great Lakes region and the salmon cases in the Pacific Northwest, rulings that cleared the way for the Makah whale hunt. The chapter argues these cases are not simply about political sovereignty or about the economic value of the treaty rights. They are also about the religious and cultural importance of those sacred practices and how the practices themselves constitute peoplehood. It also signals where protecting religion as peoplehood, under international law and especially under federal Indian law, can have its limits, particularly in the short term.


The private information analysis is strictly inherent to the protection of corporate interests. This generally means protecting the company from fraud, theft of industrial secrets, and intellectual capital as well as protecting its cyber architecture. The tasks are delicate and suited to the various corporate interests. This information work would usefully be placed in the national intelligence context by providing a precious link between the national security services and the company itself, to which such an adhesion would be difficult to guarantee in any other way.


The ancient cultures of the countries bordering on Western China were influenced by exchange with their neighboring countries in one or some form and developed. It was the very Silk Road that laid the stage for this exchange. The cultural exchange of the Tarim Basin(X?nJi?ng at present) located in the middle region of the Silk Road was vibrant in the Han and Tang dynasties. As the maritime Silk Road began to develop, the oasis(overland)Silk Road began to vanish and accordingly the ancient civilization of the countries bordering on Western China gradually came to disappear into the sand desert. The vestiges of this exchange can be found in pictures or in records. The figures or objects found on the mural painting or excavated remains provide a clue for us to figure out the living cultures of that times. Therefore, they can be said to be the valuable material in the field of the academic research related to the ancient history. The mural paintings in the Kizil stone cave contain Buddhist contents and depict music as the expression of religious faith. For this reason, there are musical instruments seen in the ancient mural paintings and those transformed into several forms in the music of the present X?nJi?ng region converted into Islam. This could be felt in the field study. It is not easy to define their origins though the external appearance of the musical instrument found in the mural painting may be like or unlike the present one. This study attempted to identify the aspect of cultural exchange in X?nJi?ng on the ancient Silk Road based on the outcome of studies conducted by several scholars and this field study in relation to the mural paintings of the Kizil stone cave. This would become the basic work to identify the aspect of exchange in the Korean history of music located on the ancient Silk Road.


Permeable reactive barrier( PRB) is a new in situ remediation technology in the treatment of the groundwater. It has been gradually applied in practice due to its obvious advantages,such as low cost,high reactivity and small environmental interference effect. The structures of PRB were systematically introduced in this study. PRBs can be divided into single and multi-processing systems based on structures. The single processing system PRB included continuous trench PRB and funnel-gate PRB,and their configurations y were improved in some degree,such as Wall and curtain PRB、Injection PRB、GeoSiphon Cell、Slurry Wall-reaction vessel and so on. The single processing system PRB is suitable for a single pollutant with low concentration,and small-scale plume site. The multi-process system included series and parallel structures. The series structures exists trench box PRB and multi-continuous channel parallel PRB; Funnel and multi-channel、multi-funnel and multi-gate、multi-funnel and channel structures are common parallel structures. The multi-process system is suitable for the complex pollution site with kinds of pollutants. The mechanism of Fe0-PRB used to remove the inorganic and organic pollutants in groundwater was analyzed. The reaction mechanism mainly was a redox reaction and reducing dehalogenation reaction during the inorganic or organic pollutants removal in the groundwater. The study further pointed out that there were passivation and clogging problems during the Fe0-PRB used in actual operation,although there were some useful solutions to solve problems,such as ultrasonic,electrochemistry. In order to improve the practicability of PRB technology,the passivation removal of iron material,the design and installation of actual site,and the long-term operation and disposal after service expiry of PRB system should be focused on in the next study.


The correlation of history and genealogy is so obvious that to call attention to it, other than for the sake of emphasis, is as superfluous as carrying coals to Newcastle. The history of a locality is bound up with the lives of its people. The branches of a family tree are intertwined with an accumulated growth of history. Genealogy, per se, might soon die of its own boredom. If its pursuit led along a dusty road only to the finding of some links in a family chain, there would be justification for that attitude of antipathy which many people hold toward the word genealogy. But genealogy is more than this. It is a por trayal of the drama of life through succeeding epochs of his tory. Rather, it is an entire literature of life, for its byways and lanes lead into romance and poetry, tragedy and much comedy, biography and history. This is what gives to the quest for an ancestry that fascination from which the devotee cannot and does not care to free himself. The genealogical importance of a state is determined largely by three rather inter-dependent factors?namely, geographical position, age, and the character of its record. That section of the United States which is now recognized as Indiana, has always benefited, both from migrations and other forces, from being on the line of march. The territorial years, plus almost a century and a quarter of statehood, have built up for Indiana an established place in history. Position and age, with some unusual contributory influences, have com bined to make of that history and its attendant genealogy a record worthy of investigation. Indiana is becoming more and more a fertile field for genealogical research. Its records are being sought not only by its own people but by those of other states with Indiana connections. For this reason, an additional source of informa tion becomes of widespread interest. The news of the inaugu ration of a section in the Indiana Magazine of History to be de voted to Indiana Genealogy and to be conducted by Mrs. Har vey Morris of Salem, Indiana, spread with almost the swift ness of telepathy. That the section takes on the nature of a tribunal before which one can lay his case, causes even greater


Two-dimensional transition-metal dichalcogenides (TMDs) are considered as the next generation of hydrogen evolution electrocatalysts due to their adjustable band gap, near-zero Gibbs free energy, and lower cost compared to noble metal catalysts. However, the electrochemical catalytic hydrogen evolution performance of TMDs with two-dimensional properties is limited by innate sparse catalytic active sites, poor electrical conductivity, and weak electrical contact with the substrate. It remains challenging for the intrinsic activity of TMDs for electrocatalytic and photocatalytic hydrogen evolution reactions (HERs) to compete with the noble metal platinum. In recent years, significant development of transition metal chalcogenides, especially MoS2 and WS2, as catalysts for electrocatalytic and photocatalytic HERs has proceeded drastically. It is indispensable to summarize the research progress in this area. This review summarizes recent research results of electrocatalysts and photocatalysts for hydrogen evolution reactions based on two-dimensional materials, mainly including MoS2, WS2, and their compounds. The challenges and future development directions of two-dimensional hydrogen evolution reaction electrocatalysts and photocatalysts are summarized and prospected as well.


The problem of link pred iction is to predict the links that does not exists and have the probability to occur in the near future. A random walk is a mathemat ical formalization of a path that consists of a succession of random steps. Node and link attributes along with node structure information are used for prediction. Supervised random walks are trained on a single snapshot of a graph at time t0 and immediately tests on its predictions for new links from a source node s at time t1. Th is paper presents an enhanced new link representation model based on implicit user feedback obtained from search engine using K-SVM queries. The main objective this approach is to achieve better results in supervised tasks, such as clustering and labelling, through the incorporation of usage data obtained from search engine queries. This type of model allows a user to discover the motivations of users when visiting a certain topic.


This investigation focused on the case of steady boundary layer flow and heat transfer of non-Newtonian fluid over a stretching sheet with Newtonian heating (NH), in which heat transfer from the surface is proportional to the local surface temperature. Casson fluid model is used to characterize the non-Newtonian fluid behavior. The transformed governing nonlinear boundary layer equations are solved numerically by means of the very robust computer algebra software MATLAB employing the routine bvpc45. Numerical solutions are obtained for heat transfer from the stretching sheet and the wall temperature for a Casson parameter and a large range of values of Prandtl number Pr. The Newtonian heating is controlled by a dimensionless conjugate parameter, which varies between zero (insulated wall) and infinity (wall temperature remains constant). The important findings in this study are the variation of the surface temperature and heat flux from the stretching surface with the Casson parameter , the conjugate parameter  and Prandtl number Pr. It is observed that these parameters have essential effects on the heat transfer characteristics. A comprehensive numerical computation is carried out for various values of the parameters that describe the flow characteristics, and the results are reported graphically.


The linear process of design-engineeringmanufacturing is nowadays obsolete. Even DFX (Design For X) methodologies are often replaced by Simulation for XFD (X being also Design) approaches. Optimization is also often applied before design. For instance, engineering design optimization of mechanical structures is nowadays essential in the mechanical industry (automotive, aeronautics ...). But optimizing mechanical structures cannot be efficient without taking in account other phases of the design-manufacturing process. In some cases, optimization is only based on trade kwnowledge. Engineers must then design parts or assemblies that are a better compromise, between mechanical and functional performance, weight, manufacturing costs etc. In this paper, after giving an overview on the different disciplines in design optimization of mechanical structures, we propose some trends to take into account the trade knowledge in the optimization/design phases. We propose an integrated approach to optimization in a functional design process with a methodological point of view. We present three different industrial cases of optimization on three examples : one in mechanical structures optimization, on based only on trade knowledge and the third mixing calculus and knowledge