Objective: A previous study conducted by our group found theory of mind (ToM) differences in preschool children who sustained mild traumatic brain injury (mTBI) compared with typically developing peers, 6 months postinjury. The goals of the current longitudinal study were to determine whether these findings are the result of a brain-injury-specific effect or rather a general-injury effect, to examine the long-term evolution of ToM skills following preschool mTBI, as well as to investigate the links between ToM abilities and general social functioning. Method: Seventy-two children who sustained mTBI between the ages of 18 and 60 months were evaluated 6 and 18 months postinjury on ToM tasks including desires and emotions reasoning and false belief understanding. They were compared with 58 participants who sustained an orthopedic injury (OI) and 83 typically developing children (TDC). Results: The 3 groups did not differ on demographic and baseline characteristics. The mTBI group obtained poorer scores relative to both comparison groups on the desires and emotions reasoning task, both at 6 and 18 months injury. No correlations were found between injury characteristics and ToM performance. For the mTBI group, associations were found between ToM performance and global social competence. Conclusion: These findings suggest a brain-injury-specific effect that persists in the long-term following mTBI in preschool children.


This research work was carried out during 2007-2010 in some Syrian governorates such as Homs, Damascus countryside and Edleb. Twenty two morphotypes of cultivated, P.mahaleb were evaluated and four superior morphotypes were selected: (HG5, RS3, EM2, ET6),which distinguished with good quality. The statistical analysis of data was done by SPSS 18 program, and the results showed that the type ET6 was recorded the greater value for the fruit's dressing percentage 81%, seed's dressing percentage 61%, productivity of fruits by tree 59.25 kg, and productivity of seed's core 6.71 kg\tree. So, this type has been surpassed morally on other types except EM2, while the type HG5 was recorded the greater value for the seed's weight(for 100 seeds) 12.25 g, and it surpassed morally on other types except RS3. Also the relationship among that types was determined by Cluster Analysis program. So, they were classified into two groups, the first contains: (HG5, RS3), the second contains:(ET6, EM2). Both groups were correlated by ratio of 67.5%, which clearly shows that there is a correlation among the studied morphotypes even though they belong to different natural spreading sites


41 Senescence is a fate-determined state, accompanied by reorganization of 42 heterochromatin. While lineage-appropriate genes can be temporarily repressed 43 through facultative heterochromatin, stable silencing of lineage-inappropriate genes 44 often involves the constitutive heterochromatic mark, histone H3K9me3. The fate of 45 these heterochromatic genes during senescence is unclear. Here we show a small 46 number of lineage-inappropriate genes, exemplified by the skin genes LCE2 in 47 fibroblasts, are derepressed during senescence from H3K9me3 regions. DNA FISH 48 experiments reveal that these gene loci, which are condensed at the nuclear periphery 49 in proliferative cells, are decompacted during senescence. Decompaction of the locus 50 is not sufficient for LCE2 expression, which requires p53 and C/EBP β signalling. 51 NLRP3 , which is predominantly expressed in macrophages from an open topologically 52 associated domain (TAD), is also derepressed in senescent fibroblasts, potentially due 53 to the local disruption of the H3K9me3-rich TAD that contains it. The role of NLRP3 54 has been implicated in the amplification of inflammatory cytokine signalling in 55 senescence and aging, underscoring the functional relevance of gene induction from 56 'permissive' H3K9me3 regions in senescent cells.


Homogeneous catalysis as the major industrial outlet of organometallic basic research has been enjoying great benefit from organotransition metal species that promote bond forming between hydrocarbon fragments. Most of the commercially important processes that serve to produce large-volume organic feedstock chemicals such as linear α-olefins (Shell Higher Olefins Process), linear aldehydes (hydroformylation), acetaldehyde (Wacker-Hoechst), acetic acid (Monsanto), adiponitrile (DuPont hydrocyanation of butadiene) operate at low-valent metal centers. It is thus hardly surprising that by far the most part of organometallic research during the past few decades has been directed towards an understanding and the improvement of these catalytic reactions as well as towards the related stoichiometric chemistry. As a matter of consequence, our present knowledge on high-valent organotransition metal compound is comparatively shallow, nor do we know much about the chemical relationship and interconvertability of high and low oxidation states within a given class of compounds. In this article I want to point out some ostensibly challenging perspectives of future organometallic research by describing a novel class of high oxidation state organorhenium compounds as well as by speculating on possible generalizations for other transition metals.


Fatigue cracking is one of the most important failure mechanisms occurring in asphalt pavements, especially when mixtures incorporate considerable amount of rReclaimed asphalt pavement (RAP). In fact, aged binders contained in RAP generally make asphalt more brittle and specifically reduce fatigue resistance of the resulting asphalt mixtures. Binders and mortars play a key role in this phenomenon, considering fatigue cracking usually starts within these asphalt components. However, performance-related tests and specifications commonly regard binders and there are no sound methodologies allowing the use of mortars to predicting fatigue performance of asphalts containing RAP. For this reason, in this paper, fatigue resistance of extracted binders from high-RAP content mixtures and of RAP mortars (passing sieve with an opening size of 0.15 mm) were assessed and compared. Binders were extracted from asphalt mixtures manufactured with 30%, 60% RAP and rejuvenators. Mixtures recipes were then reproduced to manufacture mortars accordingly. Time sweep tests in stress-controlled mode were carried out on both materials (binders and mortars) and the resulting fatigue laws were compared. As a result, a strict correlation was obtained, leading to affirm fatigue-related properties of RAP mixture could be assessed by directly testing RAP mortars. This makes the recovery of RAP binders unnecessary. Moreover, a relationship between the two fatigue laws versus the percentage of fine particles in the mortar was found. This latter relationship allows determining the fatigue law of mortars corresponding to any percentage of fine particles and therefore corresponding to any percentage of RAP.


The Concentric MESFET (CMESFET) is a small-signal, traveling-wave transistor in which a grounded source electrode surrounds and shields the gate and drain electrodes from electromagnetic fields generated by other nearby circuit elements. S-parameters for the transistor are computed to obtain gain curves for several design configurations. For a gate length of 2 /spl mu/m, maximum gain occurs with a gate width of 3.0 mm. The CMESFET has a calculated bandwidth of 17 GHz for this gate length and a gate width of 300 /spl mu/m. Coupling capacitances between device electrodes and a nearby transmission line are calculated to demonstrate how the shielding source electrode isolates the device from interference and crosstalk originating in the surrounding circuit. The CMESFET geometry exhibits shielding characteristics better than those of conventional small-signal FET geometries. >


The effect of H2O2 on platelet metabolism, aggregation and release was studied by the in vitro exposure of 3H-adenine labelled platelet rich plasma (PRP) to H2O2. On incubation of PRP with H2O2 (100 to 500 μM final cone.) over a 30 minute period, there was a mean drop of 38% in the baseline steady state levels of radioactive metabolic ATP, the fall occurring in the first 3 minutes of incubation, with a corresponding increase in the levels of radioactive inosinemonophosphate and hypoxanthine. This was not a nonspecific lytic effect on the platelet since no extracellular leakage of platelet nucleotides occurred during the incubation. Further, mean decreases of 8 to 38% in steady state levels of platelet metabolic ATP were observed during incubations of PRP with 5 to 500 μM H2O2 respectively. Finally, the action of H2O2 on adenosine diphosphate (ADP) induced biphasic aggregation and release was studied in PRP preincubated for 3 minutes with H2O2 (100 to 500 μM). Partial inhibition of the primary wave, and complete inhibition of the second wave of ADP induced aggregation was observed in the H2O2 pretreated platelets, con-commitant with inhibition of release of platelet non-metabolic ATP and ADP, when compared to the control saline preincubated platelets. Since H2O2 is generated in vivo by bacteria and leucocytes during phagocytosis, the in vivo effects of the described inhibition of H2O2 and its possible role in platelet-leucocyte-bacterial interaction requires further elucidation.


To self-adaptedly deduct the chromatogram baseline of dissolved gas in transformer oil,a half peak width and profile extraction-based baseline deduction method was proposed.The algorithm of the profile extraction-based was as follows,firstly,constructing a sliding window,secondly,sliding the window following the chromatogram data while recording the minimums data of the window,finally,interpolating and smoothing the minimums,then the baseline was obtained.The algorithm of the wavelet and profile extraction-based was as follows,firstly,extracting a preparatory baseline using wavelet filter,secondly,subtracting the preparatory baseline from the chromatogram data,thirdly,extracting baseline from the subtracted data using the profile extraction-based algorithm,finally,adding up the two baselines,the real baseline was formed.To weaken the relationship between the above methods' effect and the width of the sliding widow,a self-adapting algorithm was proposed,namely,deducting baseline from the chromatogram data using the wavelet and profile extraction-based method,then,calculating the half peak width of every component from the deducted data,thirdly,multiplying the maximum half peak width by a factor,finally,taking the multiplied half peak width as the sliding window width and applying the wavelet and profile extraction-based method to the original chromatogram data,then the real baseline was extracted.An experiment was performed to compare the self-adapting method and the results show that self-adapting method is superior to the latter,it is hardly related to the width of the sliding window and can self-adaptedly extract baseline from the transformer chromatogram data.The suggested method can be widely applied to the field of transformer oil dissolved gas measurement.


A method and system for anatomical landmark detection in medical images using deep neural networks is disclosed. For each of a plurality of image patches centered at a respective one of a plurality ofvoxels in the medical image, a subset of voxels within the image patch is input to a trained deep neural network based on a predetermined sampling pattern. A location of a target landmark in the medical image is detected using the trained deep neural network based on the subset of voxels input to the trained deep neural network from each of the plurality of image patches.


Accountancy, as a practical and applied science, is undergoing a constant process of evolution and improvement. Among the symptoms of this improvement, which has been brought about by a significant intensification of competition generated by the globalisation of the world economy, are changes in the structure of accounting. In this article, the author addresses the structure of contemporary accounting and describes its basic function. (original abstract)


In particular, the electrically conductive polymer molding of the present invention relates to a structure having conductivity on the surface, and a method for producing such a polymer molding. Another aspect of the present invention especially relates to the use for producing conductive structures electrically conductive instrument on the surface of the polymer molding. Further, the present invention relates to an adhesive comprising carbon nanotubes (CNT) for the electronic component and the other conductive member electrically conductively connected or molded parts. Further, the present invention relates to a circuit board arrangement, which comprises at least one circuit board equipped with at least one electrically conductive circuit board traces. Preferably, at least one conductive trace comprises a metal layer, and / or at least one electronic component. The present invention further relates to a method of manufacturing a circuit board according to the present invention for the equipment.


License plate detection and recognition system (LPDR) is applicable to wide range of uses such as highway toll collection, traffic management, and many more. One of the problems of this application is finding the position of license plate from cars because many cars have difference in uncertain positions of license plates and unclean license plates. The purpose of this project is to assess the efficiency of simple algorithm, applied to find the position of license plates from a video frame. This research can detect a license plate from the front or the rear of a car.The program in this project allows users to capture the picture from the video file and then the program will create the screenshot. Lastly, the program will detect the license plate position of that screenshot. The image captured by our program will appear in the .jpg file format. The accuracy of this project is around 82% for a video screenshot image, and 92% for a digital camera image.


Low-temperature nitration of the title compounds in acetic anhydride gives 1,2 nitronium acetate adducts, except p-fluorotoluene which gives both 1,2 and 1,4 adducts and α-p-tolyloxyisobutyric acid which gives a spiro adduct.


Many institutes are offering lectures that students may watch online. These lectures vary in type from true multimedia sophisticated documents to eLectures to videotaped regular lectures that may include auto generated closed caption. This paper studies some formats that can be easily composed by instructors. Whether adopting the eLectures format or videotaped lecture format, the paper proposes two automated mechanisms to create such lectures without the intervention of a camera or video mixer operator. The first mechanism depends on the absence of mouse motion events; while the second mechanism depends on the instructor's facial and hand detections.


The positioning problem of mobile robot is an important part of control problem for mobile robot. Dead Reckoning is widely used for positioning of mobile robot. However this method has problems because it accumulates estimation errors. In this paper, we propose a new method to increase the accuracy of estimated position using the U-SAT (Ultrasonic Satellite system). U-SAT is composed of a distance measurement using ultrasonic wave and the position acquisition in the world coordinate using the GPS. It is shown that we will be able to estimate the position of mobile robot precisely, in which errors are not accumulated. The experimental results show that the proposed method is enable to estimate the position of the mobile robot.


PURPOSE: To cost effectively produce a nitrided steel plate for smooth and distortion-free decorative laminated plates having excellent wear resistance by subjecting an iron based press plate to a nitriding treatment with nitrogen ions generated by a glow discharge from gas contg. nitrogen. CONSTITUTION: A cooling chamber 16 is formed between an outer wall 12 and an inner wall 13 and a thermal deflection shield 14 is arranged therein, by which a cylindrical reaction vessel 10 is constituted. The press plates 50 are hung and held via press plate fixtures 100 in this reaction vessel 10. The press plates 50 consist of iron-based stainless steels and are surface finished to a mirror finished surface form substantially free of surface flaws and distortions. The dimensions thereof are formed to a rectangular prism of, for example, ≥3ft×7ft×1/4 in. The inside of the reaction vessel 10 is evacuated to a vacuum and while a gaseous mixture composed of the nitrogen and hydrogen is supplied, the glow discharge is executed with the press plates 50 as a cathode and the vessel walls as an anode. The gases are thereby converted to a plasma and the press plates 50 are nitrided by the generated nitrogen ions, by which fully case hardened parts of hardness ≥55 HRc and depth ≥0.0001 in are formed. COPYRIGHT: (C)1995,JPO


The article explains what a digital library is and how it is designed and implemented. It also explains design issues like hardware, software, storage of information, search engines, accessibility and security.


An electromagnetic velocity spectrometer or beam separator was designed for the Cosmotron to create a meson ( pi /sup +/) beam. Physical principles of beam separator operation, beam separator design features, aspects of operation, and use in the meson ( pi /sup +/) beam are discussed. (M.C.G.)


1. Within the SEELB the CASS service oversees school improvement. CASS provides support for schools to help raise standards. CASS also ensures that all schools located in the Board Area, that are required to do so, have an agreed action plan in place to address areas for improvement identified by the Education and Training Inspectorate within the required timescales. Furthermore, CASS provides support to help schools deliver progress against the action plan and in the case of catholic maintained schools, this is taken forward in liaison with the CCMS.


A tri-band patch antenna with dual rampart line structure is presented. The proposed antenna consists of a rectangular patch, and a rampart line structure with stubs of optimized lengths. The rampart line structure is etched into a rectangular patch for achieving size reduction and arising a new mode. The n = 0 harmonic of the rampart line makes TM100 mode of the rectangular patch resonate at a lower frequency. And the n = −1 harmonic of periodic rampart line will introduce a new resonance frequency. Combining the above two frequency and TM010 mode, a triband antenna is designed and manufactured for the Chinese 5G working bands. The results of simulation and measurement show good agreement. The proposed antenna works at 3.56, 4.83, and 5.84 GHz. The electrical size of the patch is 0.22 λ0 × 0.20 λ0 × 0.023 λ0, in which λ0 is the wavelength of the lowest frequency at 3.56 GHz. Experimental results show an excellent performance in terms of radiation patterns, gains, cross-polarization level, and front-to-back ratio over the operating bands.


The purpose of our experiment was to determine the relationship between canopy cover and the density of seedlings and saplings in an aging Scotch pine (Pinus sylvestris) plantation in Emmet County, Michigan. For this experiment, we marked off a total of 24 4 x 4 m plots through randomly generated coordinates, to record seedling density and sapling height and density. In the middle of each plot, a spherical densiometer was used to measure canopy cover. Linear regressions were used in order to determine the relationships between canopy cover and seedling density, sapling density, and sapling height. The results indicate a significant negative correlation between seedling density and canopy cover after excluding one outlier plot from our data. There is also a significant negative correlation between sapling density and canopy cover, but only a weak correlation between sapling height and canopy cover. Our findings suggest that seedling and sapling density increase as a result of less canopy cover. I grant the Regents of the University of Michigan the non-exclusive right to retain, reproduce, and distribute my paper, titled in electronic formats and at no cost throughout the world. The University of Michigan may make and keep more than one copy of the Paper for purposes of security, backup, preservation and access, and may migrate the Paper to any medium or format for the purpose of preservation and access in the future. Kaitlynn Forde, Forde, Janice Ho, Megan McConnell, and Paul McKeighan Forde, Ho, McConnell, and McKeighan 2 Introduction Waldron Fen is a 59 hectare property owned by the Waldron family, who removed development rights from their property in an effort to maintain it as a bird sanctuary and preserve the natural character of the land (Little Traverse Conservancy, 2002). It is located about 32 km southwest of the University of Michigan Biological Station, in Emmet County, Michigan. Part of the property was used as a Christmas tree plantation by the previous owner (Bermudez et al, 1997). The conifers originally planted for the Christmas tree plantation are still present, although there have been plans to remove many of them and replace them with scrub ground cover found in surrounding wetlands (Bermudez et al, 1997). Within the Waldron Fen plantations, two main species of trees exist: Scotch pine (Pinus sylvestris) and Norway spruce (Picea abies). For our study, we focused on the Scotch pine plantation as it had greater light availability based on initial observations. The Scotch pine thrives in an acidic environment. Its optimal pH ranges from 4.5 to 5.2, but it can tolerate a range of 4.5 to 6.0 (Greenwood and Lowe, 2006). Scotch pines grow under a wide variety of conditions, including extreme cold and hot temperatures (Bums and Honkala, 1990). The Scotch pine also thrives in dry conditions by establishing deep roots in order to outcompete other vegetation (Burns and Honkala, 1990). However, Scotch pine seedlings are shade intolerant. Therefore, successful germination and growth of a seedling is uncommon in areas of dense canopy cover (Burns and Honkala, 1990). Germination and seedling growth greatly depend on gaps in the canopy for access to sunlight (Cooley and Wolosin, 2002). When a canopy gap forms, the dynamics of the understory change with the additional light resource. This enables the trees that are fast-growing and good competitors to sprout and form the next generation canopy (Cooley and Wolosin, 2002). Forde, Ho, McConnell, and McKeighan 3 Therefore, we predict that seedling recruitment will be greater in areas with less canopy cover. Furthermore, we predict that saplings will be more abundant and have a higher average height in areas with less canopy cover.


An access control method for a private base station, comprising: step S402, after establishing a communication connection between the terminal and the radio access network, the terminal sends a service request message to the core network, and the service request message carries the user's core network users identification; step S404, the response to the service request message, the core network core network according to user identifier queries the database to obtain the user's radio access network user identifier; step S406, acquires the core network a radio access network user identifier transmitted to the wireless access network, a radio access network and a radio access network user identifier in accordance with embodiments of the access control terminal. By using the present invention, so that the owner of the private base station can directly control the access rights of users in the radio access network side to prevent the unintended user's private cell provides radio access service; Further, the embodiment of the access control desired data record into the private base station, the owner of the private base station to facilitate the access rights of the user in real time maintenance.


HE word "perplexities" refers to me; "centenarian," of course, to Beethoven to whom music-publishers owe a debt of gratitude which they never can repay but which some of them are rather too prone to forget. When they think of Beethoven at all, they think only of his own fairly profitable compositions, but their patronizing or indifferent attitude towards "high-brow" composers does not relish the observation that Beethoven's influence has so permeated all strata of musical life that many even commercially very profitable "medium-brow" or "lowbrow" composers are descended from him -if not at right-hand, then at least at left-hand. Indeed, I make so bold as to assert that we "honorable rascals," as the irate master called us publishers, would be in a sorry plight if we had neither a Beethoven nor other composers of similar cranial loftiness to fecundate more or less


Programmable delay device (200) comprises a first delay stage having a delay cell comprising a passive network (214) (230) (210), the first stage can result in a first time delay. The apparatus further comprises a second delay stage (220) including a plurality of delay cells (240_1,240_2,240_3,240_4,240_5,240_6), each delay cell has a large second time than the first time delay it can lead to delays. Method of delaying an input signal (INPUT) includes a receiving delay selection command based on a desired time delay (sel_dly0 ... sel_dly6), selected from a plurality of delay cells (210, 220) in accordance with a delay selection command, at least one one of and a establishing a circuit transmission line comprising a delay element, at least one of the plurality of delay cells includes a delay element having a passive network (214) (230). .FIELD 2


This work deals with the identification of unknown delayed systems as continuous-time models with dead-time. The identification experiment involves the collection of data samples with the application of step input, which is popular due to its simplicity. The gain elimination method is employed to bring dead-time into the parameter vector. The model parameters are estimated using two stage identification approach, where the first stage is simple least square and the second stage is instrument variable. The over-parameterized information vectors are computed using filtered derivatives. Simulation experiments are performed on benchmark systems to validate and compare the efficacy of the proposed approach with sensor noise.


Recent experiments on the static and dynamic properties of polycrystalline colloidal solids show a pronounced influence of morphological details. Here we investigate several possibilities to vary systematically one key morphological parameter, namely the average crystallite radius rc of polycrystalline solids. We report measurements of rc as observed by microscopy in well‐characterized Yukawa model suspensions. The pair energy of interaction is systematically varied through precise experimental adjustment of the suspension parameters packing fraction Φ, number of ionic surface groups N, and concentration of screening ions c. The average size is found to systematically decrease with increasing interaction. At fixed suspension parameters we performed solidification under shear, i.e., in the presence of alternating electric fields. We report preliminary results in dependence on both the electric field strength and frequency. The grain size increases with increasing shear rates. It shows a complex behavior as...


ACE2 interaction network caused by virus infection can affect the expression levels of miRNAs and influence severity of COVID19. This study aimed to analyse the diagnostic/predictive utility of ACE2-related miRNAs, identified by in silico analysis: miR10b, miR124, miR200b-3p, miR26b, miR302c-5p in patients with COVID-19, and aimed to unravel the functions of miRNAs, by using machine learning-SHAP analysis for clinical data and bioinformatic tools. Blood samples and clinical data of 79 patients and 32 healthy were collected at; day of admission, 7days and 21days after admission. Endpoint was hospitalisation length of stay (>21days) and/or death in follow-up. Delta low miR200b-3p expression (7days-admission) presents predictive utility in assessment of the hospital length of stay and/or death (AUC:0.73,p=0.002). Logistic regression analysis showed that delta low miR-200b-3p, diabetes are independent predictors of increased hospital length of stay and/or death (OR=5.8;CI=0.57-21.21;p= 0.008, OR= 4.9;CI=1-23.9;p=0.04). MiR-26b-5p and miR10b in patients were found lower at the baseline, 7 and 21days after admission compared to healthy controls (p<0.0001 for all time points). SHAP analysis showed miR200b-3p (day7), miR302c-5p (day7), CRP (day7), neutrophils (day0), and DDimer (day0) as most promising predictors of long hospitalisation. Pathway-enrichment showed the following top pathways of the interleukin-2 signaling pathway, and cancer pathways. MiR200b-3p showed regulation of COVID19-related targets associated with Tcell protein tyrosine phosphatase and HIF-1 transcriptional activity in hypoxia, key pathways in COVID19. Bioinformatics analysis showed miRNAs roles in multiple CVDs phenotypes associated with COVID19. We validated/characterized miRNAs which can serve as novel, predictive biomarkers of the long term COVID19 hospitalisation and can be used for early stratification of patients and prediction of severity of infection.


Aiming at service robots finding the target under the home environment,a combination of RFID and visual programs is proposed,and SIFT operator is used for identification. This scheme can ensure a faster and more accurate target location of robots.


In large industry production facilities, twelve pulse rectifier units are often used for the conversion to DC-current. In order to improve the harmonic signature from the plant versus the grid, several transformer units are internally phase-displaced by means of combined couplings involving Z-arrangement. This paper outlines how such a transformer is modelled in ATP both as a Saturable Transformer component and as a coupled RLmatrix. An actual industrial plant with 5 12-pulse rectifying units in parallel is modelled with 6o phase displacement. The analysis of the harmonic content of the supplying current shows that this arrangement is equivalent to a 60-pulse system only in the case of perfect symmetry in the system. Measurements show that the 3, 5 , 7, 11, and 13 harmonics easily exceed the theoretical 59 and 61 harmonics.


The main purpose of this work was to assess the removal of the herbicide oxyfluorfen and chemical oxygen demand (COD) in aqueous solution using the electrocoagulation process. The results showed that the maximum removal efficiency for oxyfluorfen and COD were (98.5% and 90%), (99.2% and 85%) and (96.1% and 70.5%) at 30 min by using iron (Fe), stainless steel (S.S) and aluminum (Al) as anode respectively, at a current density of 75 mA.cm-2 and pH of 5.8. The energy consumption in the electrocoagulation process at optimum conditions (15.9, 16.65 and 14.1 KWh/m3) using Fe, SS and Al electrodes respectively. The adsorption of oxyfluorfen preferably fitting the Freundlich adsorption isotherm. The adsorption process follows the first order kinetic model with good correlation.


Present state of the residual ore in 100# orebody of Dachang mine and the basic conditions and principle of safe extraction of it are analyzed briefly.The safe and practical technical measures of the residual ore extraction have been presented.and the remaining ore recovery is 98%.


Abstract This paper presents a real-time feedrate-controlled interpolator (FCI) for accurate feedrate control of computer numerical controlled (CNC) machine tools along non-uniform rational B-spline (NURBS) curves for precision machining. Unlike most of the existing interpolators that are developed based on the Taylor's expansion, the proposed method uses a predictor—corrector algorithm instead. In the predictor stage, an efficient algorithm is used to estimate the servo command of the next sampling time, and in the corrector stage, the errors arising from the prediction can be corrected. This study conducts an extensive mathematical analysis of the FCI, where the criterion for selecting the sampling period, i.e. sampling period bound, is also established. The experimental results are presented to demonstrate the feasibility of the proposed FCI for machining the NURBS curves.


Existing timing verification tools can provide methodologies for identifying and optimizing critical true paths in a embedded combinational module; however the problem of justifying these paths to the chip level is a very difficult one. This paper addresses the problem of timing verification at the entire chip level. We use a critical path tool, CRITIC, to obtain critical paths in an embedded combinational module. In order to reduce the complexity of checking whether the module-level critical path is indeed critical at the chip level, we use techniques from formal verification to extract the control behavior of the circuit, and check whether there is any control sequence which will justify the path to the chip level. The results of the experiments on several processor designs show that our approach is very effective in large sequential circuits such as microprocessors, where conventional ATPG techniques require inordinate amounts of CPU time. The experiments also show that the execution time remains reasonable as the circuit size increases, since we deal with a reduced control space rather than the entire state space of the circuit.


The assessment of sediments produced, displaced, and deposited by landslides is important for hazard evaluation and mitigation. However, existing methods for landslide identification seldom address the effective separation of their internal constituents (source and transport). This letter presents a methodology to classify these constituents in very high resolution remotely sensed images. It is based on an ensemble of Texton classifiers using spectral and textural information. An experimental strategy is devised to evaluate different ensembles of features. An overall accuracy of above 90% is obtained in a cross-validation procedure in GeoEye-1 images from test sites in Madeira Island.


People games and competitions develop vitally important motor skills, forming character, moral principles, esthetic features, they have become as independent system of education. The importance of the people entertainment games is considered in the article.


ï~~2003 THE MICHIGAN BOTANIST 171 2003 THE MICHIGAN BOTANIST 171 THE VASCULAR PLANTS OF TAYLOR COUNTY, WISCONSIN Douglas M. Fields N16556 Borglin Avenue Withee, Wisconsin 54498 firstname.lastname@example.com To my son, Asa May your generation possess the Earth-wisdom so many of mine lacked. CONTENTS Introduction........................................................................................... 172 Location and PDF


Continuous training of teachers presents a wide range of actions focused on the ability to choose and make decisions because the dynamics of these actions correlate with the needs of professional and personal development. The process of in-service teacher training requires a systemic approach. The professional field size of teacher interaction has three dimensions:social, comunicative and the axes of the professional balance at the personal (I), professional (Profession) and the general work environment (Environment) levels. This article focuses on the dimensions of the professional field of teacher interaction, as a response to what a teacher is or does.


In this article is introduced the practice in reducing the production cost of pure combed yarn by suitably assorting cotton, optimizing processing parameters and using middle rubber covered roller to stabilize the product quality within the 25% level of 2001 Uster statistics.


There are a number of needs to be met for an effective school inclusion of deaf people, especially with regard to life and nature sciences. One of them concerns the construction and development of appropriate methodological strategies for teaching deaf students. To get an overview of recent productions involving teaching science to deaf students, this work aimed to map the publications made in the last 5 years in some of the important journals in the area of teaching and/or education in life and nature sciences. The results pointed to the low number of publications dealing with science teaching for deaf students. Two hypotheses are suggested for discussion of this context. One of them would be that these works have been published in significant quantities and qualities under other formats or in other journals. Another hypothesis, more worrisome, is that these works have not really been developed and published, despite the importance that they would have for the school inclusion of deaf people in relation to science education.


98 Background: With approvals across multiple cancer types and favorable toxicity profiles, oncologists may consider using immunotherapy (IMT) while their patients are hospitalized. Inpatient IMT may be cost-prohibitive to administer for most institutions due to high cost and inpatient payment structure, but little data are available to evaluate outcomes for IMT in hospitalized patients. We investigated the survival benefit of administering IMT to hospitalized patients with cancer at an NCI-designated cancer center. Methods: We conducted a retrospective chart review of all patients receiving ipilimumab, nivolumab, or pembrolizumab during inpatient admission at Dana-Farber Cancer Institute/Brigham & Women's Hospital in 2017. For each patient, we assessed: total dose, indication for dosing, cancer type, time between dose and discharge, time between discharge and death, and total cost (average wholesale price). Study follow up was January 1, 2017 to July 1, 2018. Results: Fifty doses of IMT were administered to 44 patients. Most patients (40) received 1 dose, 2 patients received 3 doses, 1 patient received 2 doses, and 1 patient received a combination of ipilimumab/nivolumab. The most common cancer types were lung (41%), gastrointestinal (18%), and head and neck (16%). Indications for IMT administration were: patient due for next dose (48%), disease progression (42%), and new diagnosis (11%). The majority of doses (70%) were received within 7 days prior to discharge, with 32% of doses within 1 day of discharge. The majority of patients (86%) died in the study period; 14% of patients died during admission. Average survival between discharge and death was 54 days (range: 0-444 days). Total cost of inpatient IMT administration was $413,370, an average of $9,395 per patient. Conclusions: To our knowledge, this is the largest analysis of outcomes for patients receiving IMT during a hospitalization. Inpatient use of IMT in cancer patients is associated with high cost and poor clinical outcomes. Dosing within one week prior to hospital discharge was common. Clinical factors such as PD-L1 status, disease status, and reason for admission, which may be important to understand which patients may benefit most from inpatient IMT, should be examined.


—"Unless and until our society recognizes cyber bullying for what it is, the suffering of thousands of silent victims will continue." ~ Anna Maria Chavez. There had been series of research on cyber bullying which are unable to provide reliable solution to cyber bullying. In this research work, we were able to provide a permanent solution to this by developing a model capable of detecting and intercepting bullying incoming and outgoing messages with 92% accuracy. We also developed a chatbot automation messaging system to test our model leading to the development of Artificial Intelligence powered anti-cyber bullying system using machine learning algorithm of Multinomial Naïve Bayes (MNB) and optimized linear Support Vector Machine (SVM). Our model is able to detect and intercept bullying outgoing and incoming bullying messages and take immediate action.


1. A balanced factorial experiment was carried out with forty-eight Merino ewes. There were two levels of each of the four factors: environmental temperature, thyroxine status, vitamin A intake and progesterone status. Each ewe was killed at 25 days' pregnancy. The embryos and their membranes were weighed and examined histologically. 2. There appeared to be no treatment effects on the embryonic length/weight ratio. The ratio between embryonic weight and 'conceptus minus fluid' weight may have been affected. There was no evidence of treatment effects on the degree of differentiation of either the embryo or the chorioallantois. 3. Surviving embryos tended to be large where thyroxine was supplied, i.e. where viability was good, and vice versa. Dead embryos fell into two groups: those less than 3 mm. long and those 6 mm. or more which had probably died shortly before the ewes were killed. 4. There were no significant correlations between the weights of live embryos and mean rectal temperature, plasma vitamin A concentration or any of the histological indices measured in the endometrium. In the hot-room live embryo weight was correlated with the height of the ewe's bladder epithelium (P < 0·01). 5. It is suggested that in the absence of adequate maternal thyroid hormone (i) the trophoblast may enlarge too slowly to stimulate adequately some response in the endometrium essential for maintenance of the embryo, or (ii) disproportionate growth in different parts of the conceptus may result directly in embryonic failure.


The appearance of unconventional pairing in superconducting cuprates is examined from a microscopic model, taking into account important properties of hole‐doped copper oxides. An exchange interaction between fermions and dominantly inter‐site bipolarons is considered to be the mechanism which leads to the pairing. Its momentum dependency is connected to the well‐established fermion–phonon anomalies in cuprate superconductors. Since charge carriers in these materials are strongly correlated, a screened Coulomb repulsion is added to this exchange term. Any ad hoc assumptions like anisotropy are avoided, but a microscopic explanation of unconventional pairing for coupling strengths that are in accordance with experimental facts is provided. One important outcome is a mathematically rigorous elucidation of the role of Coulomb repulsion in unconventional pairing, which is shown to be concomitant with a strong depletion of superconducting pairs. The theory, applied to the special case of LaSr 214, predicts at optimal doping i) a coherence length of 21Å , which is the same as that obtained from the Ginzburg–Landau critical magnetic field measured for this material, and ii) d‐wave pair formation in the pseudogap regime, that is, at temperatures much higher than the superconducting transition temperature.


Two techniques are presented for constructing new anticodes from known anticodes, namely the product and interleaving of anticodes. The product of anticodes (m1, k1, δ1,) and (m2, k2, δ2) produces an (m1m2, k1k2, δ) anticode, where δ1δ2 ≤ δ≤ min [m1δ2, m2δ1]. Interleaving of degree λ of an (m, k, δ) anticode produces an (mλ, kλ, δλ) anticode. The efficiency of these constructions is examined in terms of the Griesmer bound for the binary case. As a result a rule is derived for selecting anticodes which can be efficiently combined either by product or interleaving.


A dual-band horn antenna operating at 94 GHz and 340 GHz is presented in this paper. The proposed structure consists of a corrugated conical horn and a tapered dielectric strip. The conical horn is responsible for 94 GHz, and is excited by vertical TE10 mode. The dielectric strip is inserted in the horn, which is responsible for 340 GHz, and is excited by horizontal LSM mode. Both of the two bands have equal beam-width in E-and H-planes. The proposed design has the merits of low cross polarization, high port isolation, and large frequency ratio. In addition, the gain in the two bands can be adjusted independently.


Through questionnaire investigation and factor analysis, this article explores the status of social integration of migrants in Shanghai's urban villages. The results show that social integration of migrants can be mapped on four dimensions: social relation integration, economic integration, psychological integration, and cultural integration. According to the factor scores, the overall level of social integration of migrants is not high, and economic integration is the lowest. Furthermore, the results of multiple linear regression analysis show that, on the whole, the destination place factors of migrants exert more influence on social integration in urban villages than the individual factors. Individual factors play the most important roles in determining the status of psychological integration, while destination place factors are more helpful in explaining the variation in both economic integration and social relation integration. The study also shows that the social integration of migrants is closely related to their living space. Finally, some policy suggestions are given.


The activated carbon was produced from reed black liquor lignin by pre-carbonized in the fluidized bed at 500℃ for 5 min and then mixed with K2CO3 at the ratio of 1∶2, followed by a 60 min activation at 900℃ in the tubular furnace. The characterization of the nitrogen and the adsorption of the nitrobenzene in the effluent indicates that the specific surface area of the activated carbon thus prepared can reach 1395 (m2/g) with a good adsorbability. The Langmuir adsorption equation is better than the Freundlich adsorption equation in describing the adsorption process of the activated carbon to nitrobenzene. FT-IR spectroscopy shows the presence of silicon in the activated carbon and the porousness of the activated carbon can be observed through SEM.


Coronary heart disease (CHD) is the leading cause of death in the US. Risk factors include poor diet, elevated TC, LDL‐C, TAG, CRP and low HDL‐C. Evaluation of overall diet is needed to determine one's degree of nutritional risk. The purpose of this study was to determine the nutritional risk of subjects using a dietary questionnaire and explore its associations with blood lipid and CRP concentrations. One hundred nine overweight and obese (mean BMI = 33.4 ± 4.3 kg/m2) older men and women (mean age = 68.9 ± 6.2 y) completed the Dietary Screening Tool (DST). Blood lipid and CRP concentrations were obtained after a 12 hour fast and measured via the Cholestech system. Mean DST score was 65.4 ±12.9. Nutritional status of subjects as determined by the DST were not at risk (n=25), possible risk (n=52), and at risk (n=32). Subjects at nutritional risk had mean TC 182.8 ± 40.0 mg/dL, TAG 161.6 ± 83.7 mg/dL, HDL‐C 49.0 ± 16.3 mg/dL, CRP 2.8 ± 1.8 mg/dL, and LDL‐C 102.1 ± 30.6 mg/dL. At risk and possible at risk subjects had significantly lower LDL‐C than the not at risk subjects (p<0.05). Pearson's correlations revealed no significance between the DST with blood lipids or CRP concentrations. Interestingly, subjects not at risk had higher LDL‐C than subjects at risk and at possible risk. More research needs to be conducted to determine if the DST risk classification is associated with known CHD risk factors in an overweight and obese older population.


The Chives's Plant (Allium schoenoprasum) came from the wild ancestors that is the native of European and Asian. The ash of chive leaves contain considerable amount of metal, enabling its usage as catalyst in the making of biodiesel. Based on the Scanning Electron Microscope-Energy Dispersive X-Ray (SEM-EDX) characterization, chive leaf ash calcined at 600 ˚C contained 26.14% potassium oxide, 17.55 calcium oxide, 21.94% carbon, and 22.05% phosphorus pentoxide. The ash of chive leaves later on, used as the catalyst on the biodiesel making from the palm oil. The highest biodiesel yield of 94.42% was achieved at reaction temperature of 60 ˚C, 3% catalyst amount, ratio of oil and methanol 1:12, and reaction time 120 minutes. Based on its density, viscosity, moisture, and total glycerol biodiesel has met the Standar Nasional Indonesia (SNI) 7182:2015. However, the purity of biodiesel still haven't met the standards, in which methyl ester content was 69.13% and the triglyceride was 18.83%.


It is known that in vitro mammalian embryo development is negatively affected by the increased oxidative stress occurring under culture conditions. The oxidative damage of cell components via reactive oxygen species interferes with proper cell function. Buffalo embryos are particularly sensitive to oxidative stress because of their high lipid content (Boni et al. 1992 Acta Med. Vet. 38, 153–161). l-Ergothioneine (LE) is a powerful scavenger of hydroxyl radicals (OH) and an inhibitor of iron or copper ion-dependent generation of OH from hydrogen peroxide (H2O2). The aim of this study was to evaluate whether enriching the in vitro-culture medium with LE improves in vitro embryo production efficiency in buffalo. Abattoir-derived buffalo oocytes (n = 854, over 6 replicates) were in vitro matured and fertilized according to standard procedures (Gasparrini et al. 2006 Theriogenology 65, 275–287). Twenty hours after IVF presumptive zygotes were cultured in SOFaa supplemented by 8 mg mL–1 BSA in a controlled gas atmosphere consisting of 5% CO2, 7% O2, 88% N2, in humidified air, at 38.5°C with 0 (control; n = 214), 0.05 mM LE (n = 217), 0.1 mM LE (n = 204), and 1 mM LE (n = 219). Cleavage rate was assessed at the time of change of culture (Day 5) and the cleaved elements were cultured for a further 2 days. The embryos obtained by the end of culture, i.e. on Day 7 post-IVF, were scored for quality, based on morphological criteria, and for developmental stage, as previously described (Robertson, Nelson 2010 Manual of the International Embryo Transfer Society 86–105). The percentages of total transferable embryos and Grade 1 and 2 blastocysts in relation to cleaved oocytes were recorded. Because the chronology of development is known to be one of the most reliable parameters for assessing quality, the percentage of fast-developing embryos, i.e. hatched and expanded blastocysts, was also recorded. Data were analysed by Chi-squared test. Cleavage rate was not affected by the treatment (71.4, 66.8, 68.7, and 63.0%, respectively, with 0, 0.05, 0.1, and 1 mM LE). The total embryo output increased in groups supplemented with 0.05 and 0.1 mM LE (31.3, 42.2, 43.8, and 21.7%, respectively, with 0, 0.05, 0.1, and 1 mM LE; P < 0.05). However, the enrichment of in vitro culture with 0.1 mM LE also increased the percentage of Grade 1 and 2 blastocysts compared with the control and to 1 mM LE (21.6, 30.9, 33.9, and 21.7%, respectively, with 0, 0.05, 0.1, and 1 mM LE; P < 0.05). Likewise, 0.1 mM LE gave higher percentages of fast developing embryos than the control and 1 mM LE groups. In conclusion, these results demonstrated a beneficial effect of LE during culture on buffalo in vitro embryo development. The dose response trial indicated that the optimal concentration is 0.1 mM that also influenced the chronology of development and hence embryo viability.


Background: In this study, the ferrous sulfate was used to remove Cr(VI) and Ni(II) ions from a real Ni-Cr plating industry wastewater. Methods: This is an applied study. The type of sampling was composite by three 5 L containers. Wastewater chemical and physical characteristics were measured in accordance with the standard methods. The concentration of un-removed metal ions was estimated by ICP-OES. The Jar test was used to carry out the chemical coagulation experiment. The results indicated that the rate of removal depended on the pH of 1.5-11, the diverse contact time of 30-120 min, and the coagulant measurement ranging from 0.5-2 g/l. Results: The optimum removal of Cr(VI) ions was observed at a pH of 7 up to 83.88% in 0.5 g/l of coagulant for 40 min. While the optimum removal of Ni(II) ions was found at a pH of 5 up to 56.33 % in 0.5 g/l of coagulant for 40 min. The scanning electron microscopy results revealed the difference between the coagulant surface while coagulation. Also, the Energy-Dispersive X-ray spectroscopy (EDX) analysis showed the presence of Cr(VI) and Ni(II) ions on the surface of the ferrous sulfate after coagulation. Conclusion: Ultimately, the results indicated that ferrous sulfate could be an operative chemical coagulant to remove Cr(VI) and Ni(II) ions from the plating industry wastewater, especially for Cr(VI) particles. The results of this study can be a useful guide to the real plating industry wastewater treatment operators.


A system for measuring the noise parameters of a device at cryogenic temperatures is described. The method includes the thermal calibration of a module consisting of a noise diode, a dispersive coupling network, a temperature sensor, heater, and a bias-tee. The magnitude and phase of the reflection coefficient presented by the module vary rapidly with frequency and the noise output of the module can be thermally calibrated by changing the temperature of the module with an internal heater. The resulting variable impedance-calibrated noise source can be used to measure noise parameters of transistors or amplifiers over a frequency range of 0.4 to 12 GHz via the wideband frequency-variation method. The calibration scheme is not unique to the module and may be applied in general to any noise source. Calibration and noise parameter measurements are made at cryogenic temperatures on a discrete transistor and two different low-noise amplifiers. The results are compared against theoretical values and those obtained using independent measurements. To the best of the authors' knowledge, this is the first measurement of a transistor's noise parameters at cryogenic temperatures using such techniques.


L-asparaginase (L-asparagine amido hydrolase, E.C.126.96.36.199) is an extra cellular enzyme that has received considerable attention since it is used as an anticancer agent. In the present study, the fungal isolates from rhizosphere soils were screened for the L-asparaginase production by using modified Czapek Dox agar containing L-asparagine and phenol red as indicator. The strain isolated from rhizosphere soil of Ipomoea muricata showed the maximum zone diameter of 1.05 cm. The 16s rDNA sequence analysis indicated that the strain was most closely related to Fusarium equiseti. Various physical and chemical parameters were optimized under solid state fermentation (SSF) for L-asparaginase production. Further, it was observed that maximum activity of 3.26 IU was achieved by employing soya bean meal as substrate, with incubation period of 48 hrs and incubation temperature at 45oC at pH 7 with di potassium hydrogen phosphate and manganese as the best phosphate and metal ion source respectively. KeywordsL-asparaginase, Fusarium equiseti, rhizosphere soil, filamentous fungi, Ipomoea muricata, Optimization parameters, Solid state fermentation Introduction L-asparaginase (L-asparagine amidohydrolase; E.C.18.104.22.168) is an extracellular enzyme used as an anticancer agent. L-asparaginase was introduced in the therapeutics due to the fact that in a significant number of patients with acute leukemia, particularly lymphocytic, the malignant cells are dependent on an exogenous source of L-asparagine for survival. Normal cells, however, are able to synthesize L-asparagine and thus are less affected by its rapid depletion produced by treatment with the enzyme L-asparaginase. The most common therapeutic indications of L-asparaginase are: treatment of Hodgkin's disease, treatment of acute lymphocytic leukemia mainly in children, acute myelocytic leukemia, acute myelomonocytic leukemia and chronic lymphocytic leukemia, lymphosarcoma treatment and melanosarcoma [1-7]. Asparaginases are found in diverse sources in nature, including bacteria, yeasts, molds, plants and vertebrates. The enzymes derived from microorganisms are the major sources of enzymes for practical and clinical use [8]. Commercially used enzymes are obtained from E. coli and Erwinia carotovora [9]. In many countries, asparaginase from only one of these sources is available for front-line therapy of lymphoblastic malignancies. There are other bacteria also which are now found to produce L-asparaginase such as Pseudomonas stutzeri MB-405 [10], Thermus thermophilus [11], Pseudomonas aeruginosa 5007 [12], Staphylococcus sp.-6A [13], Bacillus circulans MTCC 8574 [14] and Serratia marcescenes SB08 [15]. However L-asparaginase from bacterial origin can cause hypersensitivity in long term use leading to allergic reactions and anaphylaxis [16]. The search for the other eukaryotic microorganisms can lead to an enzyme production with less adverse effects. It has been observed that eukaryotic microorganisms like yeast and filamentous fungi genera such as Aspergillus, Penicillum and Fusarium are commonly reported in scientific literature to produce L-asparaginase with less adverse effects [17-20]. Therefore, in the present study an attempt has been made to isolate the filamentous fungi from rhizosphere soils, molecular identification and optimization of L-asparaginase production by Fusarium equiseti. MATERIALS AND METHODS Isolation of filamentous fungi Soil samples were collected from the rhizosphere of different plants at various locations around Karnataka University Dharwad campus. The fungi were isolated by plating serially diluted sample on Czapek-Dox agar, pH 6.2. Individual colonies were regrown at 280C for obtaining pure culture. Hosamani R and Kaliwal BB 109 International Journal of Microbiology Research ISSN: 0975-5276 & E-ISSN: 0975–9174, Vol. 3, Issue 2, 2011 Screening of L-asparaginase producer by plate assay The isolated colonies were screened for L-asparaginase production on modified Czapek-dox agar [21] containing g/l of distilled water: Glucose,2.0; L-asparagine,10.0; KH2PO4,1.52; KCl,0.52; MgSO4.7H2O,0.52; CuNO3.3H20,trace; ZnSO4.7H2O, trace; FeSO4,7H20,trace; Agar,18.0, pH 6.2 and this media was supplemented with phenol red 0.009%(v/v) [22] and incubated at 280C for 96 hrs. Control plates were of modified Czapek-Dox's medium without dye and without L-asparagine. The zone and colony diameter were measured after 48 hours. Colonies with pink zones around the colony were considered as L-asparaginase producing strains. The broth studies were carried out in order to compare the results obtained with the positive isolates for plate assay. The isolate with highest zone of clearance was sent to Agharkar Research Institute, Pune for molecular identification. The sequence obtained was analyzed by using nBLAST at NCBI (http://ncbi.nlm.nih.gov/blast.cgi). Further fermentation studies were carried out with the same isolate. Optimisation of fermentation parameters The production of L-asparaginase by Fusarium equiseti under solid state fermentation conditions mainly depends on various factors like substrate selection, temperature, initial pH, phosphate source and metal ions. In order to achieve optimized activity under SSF conditions each parameter is varied one at a time. All experiments were conducted in five replicates and the mean values were presented. Effect of various substrates Seven different substrates such as fruit wall of Spathodea companulata, Acacia concinna, Pletophorum ptericarpum, Poincia regia, agro wastes such as Soya bean meal, jowar bran and sugar cane bagasse were assessed for the production of L-asparaginase. The best solid substrate is selected for further optimization studies. Effect of initial temperature The effect of temperature was studied by cultivating Fusarium equiseti on 10 gm of soya bean meal and the flasks were incubated at 10, 25, 37, 45 and 55oC respectively for 48 hours and enzyme assay was carried out as described by Imada et al., [23]. Effect of initial pH To determine initial pH, 10 gm of Soy bean meal was taken in different Erlenmeyer flasks moistened with 70% moisture and pH were varied in the range of 4-7 by using 1N NaOH and 1N HCl. Fusarium equiseti was inoculated and incubated at 45oC for 48 hours. Effect of phosphate source Various phosphate sources like di-potassium hydrogen phosphate, potassium di-hydrogen phosphate and diammonium hydrogen phosphate and 0.25-1.25% with 0.25% increment in concentration were supplemented to the substrate and further enzyme activity was carried out by extracting the fermented substrate. Effect of metal ions To determine the effect of various metal ions, the substrate was incorporated with metal ions such as Mn2+, Zn2+.Mg2+ and Cu2+ respectively at the concentration of 0.01-0.03% and the flasks were incubated at 45OC for 48 hours. After incubation enzyme activity was carried out. Extraction of fermented substrates One gm of fermented substrate was taken out periodically every 24 hours in aspetic conditions and phosphate buffer (1:10) was added to it. The contents of the flasks were kept shaking and the homogenized sample were filtered and centrifuged. The supernatant was used to carry out the enzyme assay. Quantitative assay of L-asparaginase activity Quantitative estimation was carried out following Nessler's reagent according to the method of Imada et al., [23]. The reaction mixture containing 0.5 ml of 0.04 M L-asparagine, 0.5 ml of 0.5M phosphate buffer (pH 7.8), 0.5 ml of an enzyme and 0.5 ml distilled water was added to make up the total volume to 2 ml. The tubes were incubated at 30oC for 30 minutes. The reaction was stopped by adding 0.5 ml of 1.5 M Trichloroacetic acid (TCA). The blank was prepared by adding enzyme after the addition of TCA. To the 3.7 ml of distilled water and 0.2 ml of Nessler's reagent 0.1 ml from the above mixture was added. After incubating the mixture at 20oC for 20 minutes the OD was checked at 450 nm with Spectrophotometer [Systronics]. The enzyme activity was expressed in International unit. International unit One IU of L-asparaginase activity was defined as that amount of enzyme which catalyses the formation of 1μmole of NH3 per minute under the optimal assay conditions. Results Isolation and screening In the present study isolation and screening of filamentous was carried out. The screening was done based on the zone of clearance as per Gulati et al., [22] method. The results revealed that out of twenty one isolates from different rhizosphere soils, the four positive potential strains show different range of zone of diameter. The isolate BBK9 from rhizosphere soil of Ipomoea muricata exhibited the highest zone (Fig. 1) of diameter of 1.05 cm than compared to be BBK14 which showed zone diameter of 0.86 cm, BBK20 showed 0.84 cm and BBK3 showed 0.52 cm respectively (Table. 1). Lasparaginase activity was 0.14 IU and pH was 8.54 in the broth containing the isolate BBK9 followed by BBK20 which showed the activity of 0.06 IU and pH of 8.43, BBK3 showed the activity of 0.04 IU and the pH was 8.10 respectively (Table.1). Therefore, the isolate BBK9 Isolation, molecular identification and optimization of fermentation parameters 110 Copyright © 2011, Bioinfo Publications from the rhizosphere soil of Ipomoea muricata showed the highest zone diameter and maximum activity, was sent to Agharkar Research Institute, Pune for molecular identification. Phylogenetic analysis based on 16s rRNA gene sequencing showed that the isolate was grouped into the genus Fusarium equiseti with Score = 1397 bits (756), Expect = 0.0 Identities = 763/766 (99%), Gaps = 1/766 (0%) Strand=Plus/Minus. The phylogenetic tree obtained by nBLAST analysis is presented in the Fig. (2). Optimization of fermentation parameters Substrates In Solid State Fermentation selection of suitable solid substrate for the fermentation is the critical factor. In the present study seven different substrates viz., Spathodea com


This article examines in detail the box-office performances of three well-known and successful Blaxploitation films from the early 1970s: Super Fly (1972), Coffy (1973) and The Mack (1973). It does so in order both to re-evaluate the extent of their commercial success as individual films in relation to widely-quoted data taken from Variety that is repeated in the existing literature, and also as a means of assisting in judging the size of the overall U.S. Blaxploitation market in relation to the wider box-office performance of non-Blaxploitation content of the period. It then uses this re-evaluated data to test whether box-office data relating to Blaxploitation films as it is presented in the existing literature on the subject is underestimated, overestimated or entirely accurately presented, and also to see to what extent Blaxploitation box-office contributed to enabling a recovery in the depressed Hollywood film-making environment of this period (1970–72).


The goal of this study is to provide a window into the physics of extinction and reignition via three-dimensional simulations of non-premixed combustion in isotropic decaying turbulence using one-step global reaction and neglecting density variations. Initially non-premixed fields of fuel and oxidant are developing in a turbulent field. Due to straining, the scalar dissipation rate is initially increasing and its fluctuations create extinguished regions on the stoichiometric surface. Later in the process, the stoichiometric surface again becomes uniformly hot. Besides using Eulerian data, this research applies flame element tracking and investigates the time history of individual points ('flame elements') along the stoichiometric surface. The main focus of the study is the discussion of the different scenarios of reignition. This paper identifies three major scenarios: independent flamelet scenario, reignition via edge (triple) flame propagation, and reignition through engulfment by a hot neighbourhood. The results give insight into the role different scenarios play in the reignition process, reveal the physical processes associated with each scenario, and provide the relative frequency of reignition for each scenario.


To jointly overcome the communication bottleneck and privacy leakage of wireless federated learning (FL), this paper studies a differentially private over-the-air federated averaging (DP-OTA-FedAvg) system with a limited sum power budget. With DP-OTA-FedAvg, the gradients are aligned by an alignment coefficient and aggregated over the air, and channel noise is employed to protect privacy. We aim to improve the learning performance by jointly designing the device scheduling, alignment coefficient, and the number of aggregation rounds of federated averaging (FedAvg) subject to sum power and privacy constraints. We first present the privacy analysis based on differential privacy (DP) to quantify the impact of the alignment coefficient on privacy preservation in each communication round. Furthermore, to study how the device scheduling, alignment coefficient, and the number of the global aggregation affect the learning process, we conduct the convergence analysis of DP-OTA-FedAvg in the cases of convex and non-convex loss functions. Based on these analytical results, we formulate an optimization problem to minimize the optimality gap of the DP-OTA-FedAvg subject to limited sum power and privacy budgets. The problem is solved by decoupling it into two sub-problems. Given the number of communication rounds, we conclude the relationship between the number of scheduled devices and the alignment coefficient, which offers a set of potential optimal solution pairs of device scheduling and the alignment coefficient. Thanks to the reduced search space, the optimal solution can be efficiently obtained. The effectiveness of the proposed policy is validated through simulations.


Long term evolution(LTE) supports large amount of data transmissions.High data rates require more complicated terminal baseband modem chip that drains the user equipment(UE)'s battery power quickly.Hence,LTE proposes an enhanced discontinuous reception(DRX) to prolong the(UE)'s battery lifetime.In this paper,with a combination of DRX,we propose a dynamic power management using hierarchical multi-level voltage island partion(HMVIP) scheme and define some power saving classes.The results show that the DRX with HMVP in a single chip of LTE terminal can achieve a better power saving performance.


The aim of this paper is to prove the existence of infinitely many radial solutions of
a superlinear elliptic problem with rotational symmetry
and non-homogeneous boundary data.


AIM
To inhibit the expression of vascular endothelial growth factor (VEGF) in colon cancer cell line by RNA interference (RNAi).

METHODS
Followed the service of E-RNAi, we designed and constructed two kinds of shRNA expression vectors aiming at the VEGF gene, then transfected them into colon cancer HT29 cells by lipofectamine(TM) 2000. The level of VEGF mRNA was investigated by RT-PCR and Northern blotting. The protein expression of VEGF was observed by immunofluoresence staining and Western blotting.

RESULTS
We got two kinds of VEGF specific shRNA expression vectors which could efficiently inhibit the expression of VEGF in HT29 cells. RT-PCR, Northern blotting, immunofluoresence staining and Western blotting showed that inhibition rate for VEGF expression was up to 42%, 89%, 73% and 82%, respectively.

CONCLUSION
The expression of VEGF can be inhibited by RNA interference in HT29 cells.


In the 1950's, a new field of education, namely creative education, rose and developed gradually in U.S.A. The developing process of creative education shows three characteristics: combining with education reform and paying attention to change educational ideas; combining with scientific research and seeking the effective approach to creativity; facing the society and devoting efforts to application and populization. The experiences of successful development of creative education in U.S.A are as follows; taking advanced theory as guide to practice and populizing under the guide of heightening; founding effective organizations to push the course forward; arousing the students to participate in creative education and getting recognization from the society in time. The successful foreign experience can be used for reference by Chinese educators.


A broad genetic base for a crop species such as wheat (Triticum spp.) may be important to reduce genetic vulnerability and assure long-term potential for genetic gain. The number and diversity of original ancestors can provide insight into relative genetic diversity within and among gene pools. Based on the coefficient of parentage values between cultivars and ancestral lines, the relative genetic contributions of ancestral lines to spring wheat (Triticum aestivum L.) cultivars were computed for successive 25-yr time periods. The cultivars were from Canada (47), the USA (133), and Mexico (90). Genetic backgrounds were studied for important changes in the ancestral base over time and to determine trends that continue today. About 124 ancestors, tracing to 32 countries on five continents, were found to have contributed to the North American spring wheat gene pool. Canadian western red spring cultivars released before 1950 had an intermediate level of ancestral diversity. Their post-1975 cultivars have narrow ancestral diversities probably due to strict quality regulations. They consist primarily of 'Thatcher' germplasm modified by a set of pest resistance genes carefully managed in backcross schemes. Before 1950, the U.S. hard red spring wheat cultivars traced to the same Thatcher ancestors but also to 'Kota' and 'Yaroslav'. Many more ancestors were added to this base after 1950 and especially after 1975. This was a side effect of the incorporation of pest resistance, most notably from sources 'Gabo-Timstein', 'Frontana', and'Kenya 58', and reduced height sources, most notably CIMMYT cultivars with new ancestry from 'Kenya 324' and Turkey. CIMMYT cultivars have also expanded their genetic base over time, with the systematic incorporation of new ancestry from various sources including winter wheats. Introduction of novel alleles from wild ancestors or other sources should contribute to future broadening of the genetic base, maximizing genetic gains, and reducing genetic vulnerability of the gene pools.


The invention discloses a multi-working-condition suspension previewing system based on intelligent networking and a control method for the multi-working-condition suspension previewing system. The multi-working-condition suspension previewing system comprises a database unit, a sensor unit, an ECU, a vehicle working condition adjusting module and an expert system. Through the intelligent networking technology, the road condition in front of a vehicle can be previewed, and the vehicle is intelligently switched among a comfort working condition, a standard working condition and an energy storage working condition. Under the comfort working condition, the parameters of a suspension can be automatically changed, so that the suspension is suitable for the current road condition; and under the energy storage working condition, energy can be recycled to supply power to vehicle-mounted electrical equipment, and therefore the purposes of energy conservation, emission reduction and environment-friendly travel are achieved. Meanwhile, information sharing is achieved through the system, and the accuracy and the validity of data in a database are guaranteed. By the adoption of the system, the taking comfort and the operation stability of the vehicle can be effectively improved, the requirements for the sensing distance and the accuracy of a sensor and the performance of a vehicle-mounted computer are low, practicality is high, and the system has the important significance in development of medium-high-grade vehicles and intelligent transportation.


Volume II presents the measured test data from the gate valve test program described in Volume I. Figure 1 shows the test loop in schematic form and identifies the instrument location and numbers. Figure 2 converts the differential pressure measurement to gallons per minute. Table 1 outlines the test sequence performed on each valve and correlates the data as it is presented here. The header on each plot defines the valve A or B, the test series number, and the test step number. Table 2 lists the test parameters measured during blowdown tests, Test 3 lists the test step matrix for qualification and blowdown tests, and Table 4 lists the test steps and system pressure and temperature for each of the tests performed. 1405 figs., 4 tabs.


Dynamic positioning system is usually used to keep marine constructions at a desired position for offshore engineering operations. Traditionally, DP system only deals with horizontal motions regardless of vertical ones including roll and pitch. However, large roll and pitch motions may be induced by thruster actions, which obviously should be avoided. A new control strategy considering roll-pitch motion control is presented in this paper. The main idea in the new control strategy is to consider roll-pitch velocity and acceleration feedback in the horizontal control law in order to avoid large roll-pitch motions. The new control strategy can significantly suppress the roll and pitch motions. In addition its effects on horizontal motions are also discussed.


We present a software framework for simulating the HCF Controlled Channel Access (HCCA) in an IEEE 802.11e system. The proposed approach allows for flexible integration of different scheduling algorithms with the MAC. The 802.11e system consists of three modules: Classifier, HCCA Scheduler, MAC. We define a communication interface exported by the MAC module to the HCCA Scheduler. A Scheduler module implementing the reference scheduler defined in the draft IEEE 802.11e document is also described. The software framework reported in this paper has been implemented using the Network Simulator 2 platform. A preliminary performance analysis of the reference scheduler is also reported.


A dynamic shut-in procedure is commonly adopted after a kick incident in order to build up the wellbore pressure, obtain reservoir information, and thereby handle the gas kick. In deep-water scenarios, the hydrate growth behaviors have a significant effect on gas migration and interphase mass transfer, which has not been quantitatively analyzed during the well shut-in process. In this study, a comprehensive mechanistic model of wellbore dynamics is developed considering gas migration and phase transitions. The simulation results show that the wellbore pressure field can be built up in different trends during different well shut-in periods, governed by gas seepage from the reservoir and gas migration along the wellbore, respectively. Masking the migration of free gas, the phase transition phenomena have a significant influence on the wellbore dynamics and bottomhole pressure. This work adds further insights into quantitatively characterizing the hydrate growth behaviors and interphase mass transfer rules of gas bubbles during a dynamic well shut-in procedure.


The approach of hiding the secret information in the covert image is called image steganography. Its goods like strength and defense is broadly used for covert communication, where the secret message is used to hide in the covert image. The least-significant-bit (LSB)-based method is a popular type of steganographic algorithms in the spatial domain. In image steganography the LSB based method is used extensively for hiding the secret data due to its simplicity and high embedding capability. In an existing method for hiding the secret data in the LSB substitution method four X-boxes are used to hide two secret bits in each pixel of the cover image. In this method using two X-box, 4 bits of secret message is hidden. This enhances the security of the secret message, with no movement of the PSNR value of the cover image.


The sharply continental climate of the northern and central regions of the Republic of Kazakhstan has determined the relevance of improving the heat supply systems of megacities (HSSM) as life support elements in the direction of improving quality, reliability, and energy-saving. It is proposed to create a basis for solving these problems by constructing state prediction subsystems (SPS) of HSSM electrotechnical complexes using intelligent information technologies. The SPS needs to contain automatic control and monitoring facilities (ACMF). ACMF, developed in specialized software environments such as LabVIEW and MATLAB-Simulink, makes it possible to predict equipment wearout based on the monitoring of the speed modes of electric drives (ED) analyzed in the space of real and virtual coordinates of ED. Mathematical and simulation ED models are developed and a database of models is created. Intelligent subsystems for predicting the resource and reliability of the equipment increase the safety of operation of the HSSM electrotechnical complexes.


There are many problems existing in innovation policy research domain. In order to resolving these problems the paper presents the concept of Innovation Policy Research Support System (IPRSS) and constructs the main framework of it. It is a resource sharing and interactive platform to support the innovation policy researcher's study and work. IPRSS is composed of innovation policy theory model, innovation policy measure model, innovation policy research basic database, innovation policy research model and technology support model. The paper gives a detailed presentation about main models and points the characters and functions of IPRSS.


The network environment today plays an very important role in communication. It Includes both wired and wireless with the recent past Ad-hoc network (MANET) has evolved over wired networks because of the mobility support features available in the MANET-with the advent of features such as infrastructure less, ability to support 10,000 of nodes in ad-hoc fashion, reliability, scalability etc, but the challenging facts of MANET is limited battery power, congestion avoidance, traffic overhead and packet loss due to critical factors. the various ad-hoc network protocols supplement the solutions towards the above factors but it was still research area to work on it for the mobility support features with excellent or efficient communication towards the communication is initially implemented towards the simple ZRP (Zone Routing Protocol) which is processed with the help of searching algorithms such as DFS (Depth First Search) along with networking topology (Mesh Network). Here also identified some node which is most appropriately fixed in that zone is specified as central node(CN) which maintains the history of details like cookies in system environment must maintain the presence of nodes states in the active environment with the node which is not participated for a long time is identified as Inactive node(IAN).Through this way the power consumption mechanism and efficient utilization of node in a ad-hoc network communication is improved with some level of extents towards the existing position. Ad-hoc network itself as no any fixed infrastructure and a node created in their own fashion and communicates with other node in a network. But, additionally focus on each node in a network thereby automatically self decision that in terms processed as self transmitting dedicated task by automatically by itself with other node in a particular (Zone) region. In this way the overall effectiveness of individual node participation is completely notified/monitored and stored for the future performance of that node. Hence, estimate the overall power aware routing (PAR) and effectiveness of an individual node in a network is identified and performance improvement is shown in graph.


A teratoma is a germ cell tumor (GCT) commonly composed of somatic tissues derived from at least 2 of the 3 germ layers, that is, ectoderm, endoderm, and mesoderm. Teratomas account for <10% of all mediastinal masses.1 The frequency of a mature teratoma in mediastinal masses is ∼6% (27/445)2, whereas the presence of hepatic tissues in a mature teratoma is extremely rare.3 Recently, 2 GCTs with hepatocellular carcinoma (HCC) components were reported: one was a testicular teratoma,4 and the other was a germinoma in the brain.5 To the best of our knowledge, this is the first report of a mature cystic teratoma with an element of HCC arising in the anterior mediastinum.


The single-well chemical tracer method has been used in over 140 tests since 1968 to determine residual oil saturation after waterflooding. Interpretation of the test involves matching tracer data from the field using computer simulation programs. As the complexity of the simulator model increases, the number of trial runs that are needed to satisfactorily fit field data increases rapidly. The conventional fitting procedure can thus become very cumbersome and can involve prohibitive computer costs. A new method has been devised to model tests in heterogeneous formations. These rigorous simulators have been replaced by simple response functions capable of being used in a standard parameter estimation routine. Matching the tracer data now involves function evaluations rather than full simulator runs, thus resulting in a large reduction in computing time. An algorithm has been developed to find best fit values for all unknown test variables, such as the flow distribution into and out of the layers, the dispersive mixing lengths and the residual oil saturations in the different layers. The method bas been verified by using it to explain both simulated and actual field data from tracer tests conducted in multi-layer reservoirs.


The invention is to provide an energy-efficient system for the utilization of waste heat and waste gases from the industrial production of carbon compounds such as carbon black, graphite or the Zuckerpyrolyse, by means of a cogeneration or a thermal power plant for producing electrical energy, in particular for the operation of furnaces and / or use of waste heat in endothermic processes, and appropriate utilization of waste heat.


AIM: To observe the haemostatic effect of hemocoagulase atrox in abdominal delivery. METHODS: Fifty-six patients received abdominal delivery were devided into atrox group (n=29) and control group (n=27) hemocoagulase atrox 2 U was adminstrated iv drip 30 min before operation, 2 U was adminstrated iv drip 2 h after operation. Oxytocin 20 IU was injected into the body of uterus and oxytocin 20 IU was intravenous dripped after fetal disengagement. The same dosage oxytocin was given to the patients of the control group. The volumes of hemorrhage in midst of the operation and 1 d after the operation was observed. RESULTS: The volumes of hemorrhage in midst of the operation and 1 d after the operation were obviously lower than those of the control group. There was significant difference between two groups(P 0.05 ). CONCLUSION: Hemocoagulase atrox can reduce the volume of hemorrhage in abdominal delivery.


The present invention of formula (I): [Formula 1] (Wherein the variables are the specification and claims are defined in section) a compound represented by, their preparation and use thereof. .BACKGROUND


Composer Mesías Maiguashca was born in Quito in 1938. He studied at the Conservatorio de Quito, as well as abroad. He taught electronic music at the Hochschule für Musik Freiburg from 1990 until his retirement in 2004, and also taught in Metz, Stuttgart, Karlsruhe, Basel, Sofia, Quito, Cuenca, Buenos Aires, Bogotá, Madrid, Barcelona, Györ, Szombathely, and Seoul. His music has been performed at the most important European festivals. Together with Roland Breitenfeld, he founded the K.O. Studio Freiburg in 1998, a private initiative for the practice of experimental music. Since 2008, he has been an advisor on the board of GEMART (Group for Experimental Music and Media Arts, Hannover) and a member of the GEMART Ensemble. He has lived in Freiburg since 1996. Sebastián Zubieta is Director of Music at the Americas Society and Music Editor for Review.


List of Tables Acknowledgments 1. Introduction 2. Capital-Market Failures 3. Effective Development Banks 4. Planning and Evaluation 5. Models The Serve Development 6. Sustainability 7. Managing the Risk 8. Minimizing the Costs of Operations 9. Capital Ins and Outs 10. The Future of Development Banking Notes Glossary Index


This booklet introduces intelligent transportation systems (ITS) professionals to European Union institutions, the activities of which can seem to be confusing and complicated at first. It presents clear explanations regarding funding streams, directorates, legislation, and research activities for individuals who work with European institutions.


ABSTRACT Nasoata Island is a predominantly mangrove island located near the outflow and delta of the Rewa River, Fiji's largest and longest river. The river originates on the eastern slopes of Mt. Tomaniivi in the Central Highlands of Viti Levu. The island has been selected as an integral coastal site for Fiji's PABITRA Gateway Transect. Information is provided on: (1) the reasons it was selected as a PABITRA site; (2) geographical, geological, climatic, and edaphic setting; (3) the vegetation; and (4) brief notes on the fauna, with particular focus on the avifauna. Because of its rich flora and fauna, Nasoata Island is an excellent "prototype" coastal and mangrove site for enhancing our understanding of the complexities of island biodiversity, both within Fiji and in relation to other small offshore islands within the broader PABITRA network.


The invention relates to a photovoltaic module (1) that includes at least two photovoltaic cells (7, 7') in series, each rectangular cell (7, 7') including, respectively, a first rear thin film electrode (5, 5'), a photovoltaic stack having at least two active materials (3) included between the rear electrode (5) and a transparent conductive electrode (TC) made of a thin film (4), said electrode TC (4, 4') being capable of collecting and transmitting an electric current (10, 10') generated by the photovoltaic stack (3, 3'), the two photovoltaic cells (7, 7') being electrically connected in series by an electrical contact strip (6) that is included between the electrode TC (4) of the first cell (7) and the rear electrode (5') of the second cell (7').; According to the invention, the local thickness (e) of the electrode TC (4) of the cell (7) varies depending on the distance to the electrical contact strip (6). The invention also relates to methods for depositing and etching the transparent conductive film (TC) so as to simultaneously manufacture a plurality of cells (7, 7', 7"...) for a single module (1).


The nature of double cross slip of screw dislocations as induced by a locked parallel screw dislocation, that of edge dislocations as induced by a locked edge dislocation through climb, and that of the cross climb of edge dislocations as induced by another edge dislocation through slip are studied in the light of the interaction of the mutual stress fields of the dislocations. Some quantitative calculations of the multiplication of a single loop and of the growth of slip bands in LiF are given; it is found that agreement with the experimental results of Johnston and Gilman [W. G. Johnston and J. J. Gilman, J. Appl. Phys. 30, 129 (1959); 31, 687 (1960)] is satisfactory. A mechanism for linear hardening at low stresses is suggested.


The influence of gender on the effects of cocaine (5 or 40 mg/kg) on immune function of sexually immature (35-day-old) C57BL/6J mice was assessed. The proliferation of T cells in thymus and spleen stimulated with phytohemagglutinin (PHA) and concanavalin-A(Con-A) was determined by 3H thymidine incorporation 24 hours after cocaine injections. The drug produced a dose-dependent reduction (25-51%) of Con-A and PHA-stimulated T cell proliferation in thymus from both male and female mice. Additionally, the impairment occurred at a lower cocaine dose for female than for male mice when the T cells were challenged with PHA. Under the experimental conditions, cocaine did not alter weights or cell numbers of thymus and spleen or T cell proliferation in spleen.


Objective To investigate the effect of Artemisinin combined with ~(60)Coγ-ray on DNA damage in HeLa and SiHa cells of human cervical cancer.Methods Cell growth kinetics was evaluated by MTT assay to determine the most appropriate drug concentration.Effects of Artemisinin combined with~(60)Coγ-ray on DNA damage in HeLa and SiHa cells were detected by single cell gel electrophoresis. Results With the concentration increased during the effect of Artemisinin,the HeLa and SiHa cells had higher inhibition on cell proliferation.The SCGE showed that:the comet cell analysis indexes(the comet cells ratio、Tail Length、Olive Tail Moment and Tail DNA%) there was no statistic difference in between the artemisinin group and the control group(P0.05).With radiation in the same dose,the comet cell analysis indexes of Hela cells treated with both artermisinin and exposed to radiation were higher than that only exposed to radiation group(P0.05),but there was no difference in SiHa cells(P0.05 ).Con- clusion Artemisinin can not induce DNA damage in both HeLa and SiHa cells,but it can make irradiated HeLa cells DNA damage to be aggravated and enhance HeLa cells' radiation sensitivity.However,Artemisinin has no radiosensitizing effect on SiHa cells.


PROBLEM TO BE SOLVED: To decrease the wear of bearing portions of a rotary anode X-ray tube by adding solids having low sliding friction to a lubricant which is made to exist in the bearing portions. SOLUTION: In a rotation anode X-ray tube, a gap between a bearing shaft 8 and a bearing outer plate 9 is preferably filled with a liquid lubricant of a gallium alloy in the region of groove pattern 11 provided at least on a bearing surface. Solids decreasing the friction between the bearing outer plate 9 and the bearing shaft 8 during startup or stopping operation are added to the lubricant. Tungsten diselenite or tantalum diselenite is appropriate for the lubricant additives. The solids can prevent wear since internal stresses are produced under the influence of stresses working along a tangent because of a layered crystal structure between the bearing portions. The content of the solids is preferably 0.05-5 wt.%.


The article is devoted to the issues of prevention and choice of therapy strategy for iron deficiency anemia in pregnant women. Iron deficiency anemia is a frequent complication during pregnancy and in the postnatal period. According to the World Health Organization (WHO), the frequency of anemia in pregnant women exceeds 40% and can reach 65% in developing countries. More than half of all cases of anemia during pregnancy are directly related to iron deficiency (ID), which can be as high as 80% or more during pregnancy. This indicates that existing iron reserves out of pregnancy are inadequate to compensate for the increasing need for iron intake during pregnancy. According to domestic authors, the vast majority of women have some kind of iron deficiency by the end of pregnancy, and some of them had a latent iron deficiency even before pregnancy. The development of anemia is preceded by sublatent and latent forms of iron deficiency associated with increased iron demand during gestation. The issues of early diagnostics of preclinical forms of iron deficiency with subsequent correction of this element insufficiency, which allows avoiding undesirable phenomena related to the development of anemia, remain particularly relevant. The prevention of iron deficiency anemia should be complex and individual, and the choice of a drug to compensate for iron deficiency should be based on high bioavailability of the drug with minimal side effects. According to available data, oral administration of bior trivalent iron preparations is not sufficient for the treatment of moderate to severe anemia. In this case, the administration of iron sulphate preparations should be combined with the prescription of prolonged or recombinant erythropoietin with a transition to intravenous administration of iron preparations.


Preface.Preface to Volume 1.Part I: OBSERVATIONAL STUDIES/EPIDEMIOLOGY.1.1 Epidemiology.Computing Estimates of Incidence, including Lifetime Risk: Alzheimer's Disease in the Framingham Study. The Practical Incidence Estimators (PIE) Macro. (Alexa Beiser et al).The Applications of Capture-Recapture Models to Epidemiological Data. (Anne Chao et al).1.2 Adjustment Methods.Propensity Score Methods for Bias Reduction in the Comparison of a Treatment to a Non-Randomized Control Group (Ralph B. D'Agostino Jr.).1.3 Agreement Statistics.Kappa Coefficients in Medical Research (Helen Chmura Kraemer et al).1.4 Survival Models.Survival Analysis in Observational Studies (Kate Bull and David J. Spiegelhalter).Methods for Interval-Censored Data (Jane C. Lindsey and Louise M. Ryan).Analysis of Binary Outcomes in Longitudinal Studies Using Weighted Estimating Equations and Discrete-Time Survival Methods: Prevalence and Incidence of Smoking in an Adolescent Cohort (John B. Carlin et al).Part II: PROGNOSTIC/CLINICAL PREDICTION MODELS.2.1 Prognostic Variables.Categorizing a Prognostic Variable: Review of Methods, Code for Easy Implementation and Applications to Decision-Making about Cancer Treatments (Madhu Mazumdar and Jill R. Glassman).2.2 Prognostic/Clinical Prediction Models.Development of Health Risk Appraisal Functions in the Presence of Multiple Indicators: The Framingham Study Nursing Home Institutionalization Model (R. B. D'Agostino et al).Multivariable Prognostic Models: Issues in Developing Models, Evaluating Assumptions and Adequacy, and Measuring and Reducing Errors (Frank E. Harrell Jr et al).Development of a Clinical Prediction Model for an Ordinal Outcome: The World Health Organization Multicentre Study of Clinical Signs and Etiological Agents of Pneumonia, Sepsis and Meningitis in Young Infants (Frank E. Harrell Jr. et al).Using Observational Data to Estimate Prognosis: An Example Using a Coronary Artery Disease Registry (Elizabeth R. DeLong et al).Part III: CLINICAL TRIALS.3.1 Design.Designing Studies for Dose Response (Weng Kee Wong and Peter A. Lachenbruch.).3.2 Monitoring.Bayesian Data Monitoring in Clinical Trials (Peter M. Fayers et al).3.3 Analysis.Longitudinal Data Analysis (Repeated Measures) in Clinical Trials (Paul S. Albert).Repeated Measures in Clinical Trials: Simple Strategies for Analysis Using Summary Measures (Stephen Senn et al).Strategies for Comparing Treatments on a Binary Response with Multi-Centre Data (Alan Agresti, and Jonathan Hartzel).A Review of Tests for Detecting a Monotone Dose-Response Relationship with Ordinal Response Data (Christy Chuang-Stein and Alan Agresti).


The main objective of this study is to identify who the school principals are from their own perspectives and according to their views, to identify how they perceived themselves and their responsibilities. This study is a qualitative research and in order to acquire the data phenomenological method, which provides to focus on cases that we are aware of but do not have deep and detailed insight, was used. The data of the study was collected by focus group interview technique. School principals in the study, expressed their ideas as follows; 1) A principal should be leader of the school. 2) School principals should be selected among teachers who are preferably successful and have master degree and career steps system should be created. 3) Selected candidate principals expressed their ideas about the benefit of on-job training (mentor-apprentice system) with an experienced administrator after the in-service training course.