Study Design Systematic review and meta-analysis of randomized controlled trials, case control and cohort studies. Introduction To evaluate the current evidence comparing Thermo-coagulation intradiscal techniques to nonoperative treatment options for the treatment of chronic Discogenic low back pain. Discogenic low back pain is a common disabling condition and major health care concern. However, it has been controversial in diagnosis and treatment. Methods We searched PubMed, EMBASE, Cochrane Library, KoreaMed and Korean Medical database (KMbase) to find out clinical studies for evaluating the effectiveness of Radiofrequency and Intradiscal electrothermal therapy for the treatment of Discogenic low back pain which were published until June 2015. Randomized controlled trials, case control and cohort studies comparing Thermo-coagulation intradiscal techniques with nonoperative treatment options were selected. Duplicate citations were removed and a total of 13,464 articles were acquired, from which 6 articles were identified for meta-analysis. Results A total of 6 citations were found and screened to determine if they would meet our inclusion criteria. Finally, 4 randomized controlled trials and 1 case-control and 1 cohort study comparing the effectiveness of thermo-coagulation and nonoperative treatment options were selected for meta-analysis and risk of bias was evaluated as assessed in accordance to guidelines following the Cochrane Collaboration's tool for assessing risk of bias in randomized trials and Newcastle-Ottawa Scale (case control and cohort studies). In meta-analysis, clinical outcomes such as Visual Analogue Scale, Oswestry Disability Index and Short Form-36 (physical functioning and bodily pain) values were evaluated and the forest plot provided a visual representation of each study and all studies combined with individual confidence intervals. Based on meta-analysis, the pooled mean difference in Visual Analogue Scale (pre – post outcomes) between the thermo-coagulation and nonoperative treatment options in all 3 randomized controlled trials, 1 case control and 1 cohort study was 2.44 points (95% confidence interval: 1.01, 3.88, p = 0.0009) in favor of thermo-coagulation procedures within 7.8 month mean follow-up periods. However, within 3 months after treatments, there was no statistically significant difference in the two treatment options. In the outcomes of meta-analysis after 3 months of treatment, thermo-coagulation procedures showed to be more favorable with MD = 2.88 points (95% confidence interval: 1.05, 4.71, p = 0.002) In Oswestry Disability Index, the pooled mean difference (pre – post outcomes) was 2.86 points (95% confidence interval: -2.40, 8.13) in favor of thermo-coagulation procedures which was not statistically significant (p = 0.29) with 4.7 month mean follow-up periods. However, thermo-coagulation procedures were more favorable with MD = 5.10 points (95% confidence interval: 0.44, 9.76, p = 0.03) only in the outcomes of meta-analysis after 6 months of treatment. The pooled mean difference (post – pre outcomes) in Short Form-36 including physical functioning and bodily pain was 7.55 points (95% confidence interval: -0.69, 15.80) and 6.47 points (95% confidence interval: -1.09, 14.04) in favor of thermo-coagulation procedures, however, they were not statistically significant (p = 0.07 and p = 0.09) with 5.3 month mean follow-up periods, respectively. Conclusion It was demonstrated from this systematic review and meta-analysis that the two treatment options had no statistically significant difference in Visual Analogue Scale scores within 3 months after treatments for the patients with discogenic low back pain, however, thermo-coagulation therapies showed a statistically significant favorable effect after 3months. In Oswestry Disability Index, there was a statistically significant favorable outcome only after 6 months of treatment. Short Form-36 (physical functioning and bodily pain), it failed to find significant differences between the two treatment options despite more favorable outcomes in thermo-coagulation therapies.


Simple, tetranuclear cationic supramolecular squares with ligands at the corners can be constructed using the geometry of the pyrimidine ligand and the directional tendencies of AgI coordination; the 1:1 AgI:pyrimidine squares have an open channel structure which facilitates selective ion exchange of pertechnetate over nitrate.


A novel method of levitation, using an actively controlled electric field, launches, captures, and stably suspends a microscopic (∼15 μm) particle in high vacuum. While held to within one diameter in the vertical direction, the particle is allowed to oscillate nearly freely in the horizontal plane under the influence of a central restoring force. The damping of horizontal oscillations was measured over the pressure range from 10−2 to 10−8 Torr. The damping was observed to be proportional to pressure down to less than 10−6 Torr, where residual (pressure independent) damping became significant. An absolute high vacuum gauge based on the pressure‐dependent damping observed with this apparatus could operate linearly throughout at least a six decade range. A prototype gauge design is suggested.


A formula for the direct computation of the steady-state gain of a recursive estimator is derived. The estimator is presented as a general 3-D recursive filter for noise smoothing of 3-D wide-sense Markov fields. The 1-D and 2-D estimators are special cases of the general filter presented. The filter with its steady-state gain computed from the derived formula is very useful because of its computational efficiency.


breadth and depth of this magnificent book, 20 years in the making, and the pressing challenges of the current pandemic plight, render the author's particular kind of 'liberation theology' less hopelessly utopian and reactionary than it might have seemed before the crisis began. Rather than retreat from the world (the 'Benedict option'), McCarraher is really advocating a 'new Franciscanism'—a renewed, engaged, political imagination, animated by a sacramental consciousness that, like St. Francis, treats all humanity and all nature as God's creatures. The future of the world may depend on it.


Background: The inadequate arthroscopic release of the tight posterior capsule in frozen shoulder may result in limited postoperative shoulder internal rotation. Indication: The purpose of this article is to describe an L-shaped arthroscopic posterior capsular release to overcome the limited internal rotation that may be encountered following the standard longitudinal technique. Operative intervention is indicated in patients with refractory shoulder stiffness with limitation of internal rotation of grade 0, +2, +4 (according to the Constant-Murley Score), after failure of conservative measures for 3 to 6 months. The technique is contraindicated if less than 3 months of physical therapy, shoulder stiffness due to osseous deformity, infection, or cuff tear arthropathy. Technique: After performing a standard anterior capsular release, the scope is shifted to the anterior portal to perform posterior capsular release by introducing the radiofrequency ablation device through the posterior portal. Posterior release begins from the glenoid level down to the 6 o'clock position until the back fibers of the infraspinatus muscle appear. Then the hook-tip part of the radiofrequency ablation device is used to perform a transverse release in the posterior capsule, starting from the beginning of the longitudinal limb. The transverse limb is performed in a stepwise manner going step-by-step laterally but ending before reaching the rotator cuff to avoid any damage of the cuff. After that, the shoulder was manipulated according to Codman technique. Results: A comparative study was performed on 43 patients with primary frozen shoulder to compare the standard longitudinal (22 patients) and L-shaped (21 patients) posterior capsular release. At the final follow-up, there was a statistically significant improvement in the internal rotation range of motion in the L-shaped group (P < .001). There was no loss of function over time. Moreover, there were no infections, instability, or axillary nerve injury in either group. Discussion/Conclusion: Restriction of internal rotation in frozen shoulder has been attributed to posterior capsular tightness. The L-shaped arthroscopic posterior capsular release in patients with primary frozen shoulder significantly improves the postoperative internal rotation range of motion. Graphical Abstract This is a visual representation of the abstract.


For the analysis of square contingency tables, it is necessary to estimate an unknown distribution with high confidence from an obtained observation. For that purpose, we need to introduce a statistical model that fits the data well and has parsimony. This study proposes asymmetry models based on cumulative probabilities for square contingency tables with the same row and column ordinal classifications. In the proposed models, the odds, for all i


ABSTRACT

Bimo Handaru Jati, 2015: The Effect of Ownership Structure and Ownership
Concentration on The Enterprise Risk Management.

This study aimed to examine the effect of ownership structure and ownership
concentration on the enterprise risk management. Independent variable in this
studyis the management ownership, institutions ownership, public ownership and
ownership concentration. The dependentvariable in this study is the enterprise risk
management.

The sample used in this study is a secondary data derived from the Indonesian
StockExchange (BEI), the annual report of the manufacturing industry in
Indonesian StockExchange listing of the years 2011-2013. Samples were taken by
using purposivesampling method. The samples used were 13 manufacture over
period of 3 years (20112013).Themethodofanalysisinthisstudyusingmultipleregression.

The

results of this study indicate that management ownership, institutions
ownership, public ownership enterprise risk management. While ownership
concentration does not effectthe enterprise risk management.

Key Words: Eterprise Risk Management, Ownership Structure, Ownership
Concentration


CONSTANTINE, D. G. 1979. Bat rabies and bat management. Bull. Soc. Vector Ecol. 4:1-9. HURLEY, S., AND M. B. FENTON. 1980. Ineffectiveness of fenthion, zinc phosphide, DDT, and two ultrasonic rodent repellers for control of populations of little brown bats (Myotis lucifugus). Bull. Environ. Contam. Toxicol. 25: 503-507. KUNZ, T. H., E. L. P. ANTHONY, AND W. T. RUMAGE III. 1977. Mortality of little brown bats following multiple pesticide applications. J. Wildl. Manage. 41:476-483. PUBLIC HEALTH SERVICE ADVISORY COMMITTEE ON IMMUNIZATION PRACTICES. 1980. Rabies prevention. Morbid. Mortal. Weekly Rep. 29:265-272, 277-280. SILVER, J. 1935. Eliminating bats from buildings. U.S. Bur. Biol. Sur. Leafl. 9. 5pp.


The introduction test of 11 alfalfa varieties was conducted in Sanjiang Plain of Heilongjiang province.Winter hardness,growing rate,stress tolerance,branch number,ratio of stems to leaves and yield for four years were compared.The results showed that Melilotoides ruehenicus×M.sativa cv.Longmu No.801,M.sativa×Melilotoides ruehenicus cv.Longmu No.803,M.sativa cv.Gongnong No.1,M.varia cv.Caoyuan No.2 performed better than others,which are suitable to be cultivated in artificial grassland in Sanjiang Plain in Heilongjiang province.


Noncentrosymmetric (NCS) silicon phosphides have recently shown promise as nonlinear optical materials due to the balance of strong second harmonic generation (SHG) activity and large laser damage threshold (LDT) values....


In the spontaneous adverse event reporting system for isotretinoin, the organ system classification "psychiatric" has, by far, the largest percentage of all serious adverse event reports.1 "Uses and Complications of Isotretinoin Therapy" by Charles N. Ellis and Kent J. Krach2 devotes 2 sentences to psychiatric adverse events, despite the prominence of the warning in the Accutane package insert and the potential for a fatal outcome. The 2 sentences are, inexplicably, found at the end of a section entitled "Neuromuscular Side Effects."


A large percentage of accidents with body injuries in urban areas occur at intersections. Thus, improving safety at intersections using infrastructure based perception systems is desirable. In order to recognize and track the moving objects, a network of laserscanners is used to observe the intersection. In this contribution, a robust object recognition algorithm for vehicles and pedestrians is proposed. Further, the Cardinalized Probability Hypothesis Density with integrated estimation of the clutter density is applied to track vehicles and pedestrians at an intersection. The performance of the system is evaluated using real world sensor data of an intersection.


To make Ir(III)-based complexes potentially multifunctional materials, two new cationic Ir(III) complexes with a 2-(5-phenyl-2-phenyl-2H-1,2,4-triazol-3-yl)pyridine (Phtz) ancillary ligand were designed and synthesized. By introducing the pendant phenyl ring into the ancillary ligand, the two complexes possess desired intramolecular π–π stacking between the pendant phenyl ring of the Phtz ligand and one of the phenyl rings of the cyclometalated ligand, which renders the complexes more stable. Density functional theory calculation indicates that the intramolecular π–π interactions in both complexes can reduce the degradation reaction in metal-centered (3MC) states to some extent, which further implies their stability. With these results in combination with their reversible oxidation and reduction processes as well as excellent photophysical properties, the stable light-emitting cells (LECs) would be expected. Furthermore, the two synthesized complexes exhibit reversible piezochromism. Their emission color can be smartly switched by grinding and heating, which is visible to the naked eye. In light of our experimental results, the present piezochromic behavior is due to interconversion between crystalline and amorphous states.


IGLOO Director Ian Cottage. Commissioned by the BBC/Arts Council of England for BBC 2's Sound on Film. First Screening: The Scientific Society Lecture Theatre, London 1999.


This case study examines residents' and tourists' perceptions of tourism in a small, colonial town in Sonora, Mexico, from the perspective of socio-economic benefits, transportation and culture. Based on a pilot survey of 132 inhabitants and tourists, the study found that while most respondents did not consider tourism to have improved the their standard of living, there is a tendency to support tourism's growth because of its potential infrastructure and economic value for the town.


Excessive application of nitrogen fertilizer has caused the reduction of nitrogen fertilizer utilization efficiency, resource waste and environmental problems in our country. There are disadvantages of long sampling and heavy workload using the traditional methods of acid absorption and box method for farmland ammonia volatilization measurement. In order to meet the application needs for on-line automatic measurement of ammonia volatilization in farmland, an in-situ automatic measurement device for ammonia volatilization was designed combined with laser spectroscopy technology. The main body of the measurement device is an integrated sampling box, with the advantages of long optical path measurement, heat resistance and corrosion resistance. The control circuit of the sampling box used ARM as the main controller for environmental data monitoring, automatic opening and closing of the cover and lens temperature controlling. The ammonia volatilization results were analyzed by the data acquisition and processing system after the laser passed through the sampling box to obtain ammonia spectroscopy signal. The device was used for observation at Fengqiu Ecological Station, CAS. The results showed that the ammonia volatilization rose rapidly after 90 minutes for nitrogen fertilizer applying, and it decreased gradually to a low value after 270 minutes. According to the experimental results, the continuous measurement time for cover closing can be set to 3 minutes, and the cover opening time can be set to 3 to 5 minutes. The working performance of the automatic measurement device was verified through these experiments, with the advantages of low power consumption, high measurement sensitivity, and no gas sampling. It realizes insitu automatic measurement for ammonia volatilization in farmland with the natural respiration condition of the soil.


It is one thing for gas prices to be high, but there is another factor—price volatility. The two factors gyrate, and such inconsistent price behavior sends inefficient signals to consumers and business.


A signature feature of Miloš Crnjanski's famous novel Seobe (Migrations), written in the Serbian language, is the author's seemingly eccentric use of punctuation marks. Odd as it may seem, the paper maintains that such punctuation serves a literary purpose, as it reg- ulates the flow of narration and imposes a strict overall rhythm. Pre- serving the original punctuation becomes a major issue in translation, especially into English, owing to the discrepancy in morphosyntactic systems of the two languages. Michael Henry Heim's translation of Seobe into English, entitled Migrations, does not follow the original punctuation pattern, thereby ignoring a series of wider implications of the syntactic, prosodic, and semantic kind. While calling for Seobe's retranslation that would pay closer attention to Crnjanski's punctua- tion, this paper argues that the key to the preservation of the novel's distinct rhythm lies in keeping the however peculiar sentence struc- tures and accompanying punctuation – as long as the rules of stand- ardized grammars are respected.


With applications in next-generation displays and lighting, on page 7162, H. Zeng and co-workers, demonstrate quantum-dot light-emitting diodes (QLEDs) based on all-inorganic perovskite cesium lead halides (CsPbX3 ) with a peak width as narrow as 20 nm and colors covering the whole visible region.


PURPOSE:To provide a rolled aluminum alloy sheet having high strength and high rigidity and excellent in heat resistance and ductility. CONSTITUTION:This rolled sheet is a rolled sheet of a high strength aluminum alloy which has a composition represented by AlbalNiaXb or AlbalNiaXbMc or AlbalNiaXbMcQd [where X means one or <=2 elements selected from La, Ce, Mm, Ti, and Zr, M means one or <=2 elements selected from V, Cr, Mn, Fe, Co, Y, Nb, Mo, Hf, Ta, and W, Q means one or <=2 elements selected from Mg, Si, Cu, and Zn, and the symbols (a), (b), (c), (d) stand for, by atom, 2-10%, 0.1-3%, 0.1-2%, and 0.01-2%% respectively] and where the maximum size of the intermetallic compound crystallized out is regulated to <=10mum. A molten alloy of this composition is simultaneously rolled while being subjected to cooling and solidification, by which the rolled sheet where the maximum size of the intermetallic compound crystallized out is regulated to <=10mum can be produced.


Measurement of information security is important for organizations to justify security decisions and investments. Unfortunately, there are no metrics available that allow for a comprehensive security assessment of an entire organization. It turned out that there are two main aspects which are important to develop such a metric. On the one hand, an appropriate security indicator is required and, on the other hand, a method for combining single security aspects to an overall security measure for an entire organization. An approach fulfilling these two aspects is presented in this article. Besides a comparable indicator, based on the intuitive understanding of security, an approach is proposed for combining single security aspects to reflect the organization's security assessment. The presented approach was evaluated on a small university department. It will influence on forthcoming ISO 27004 metric-standard, which aligns with the already existing and well known ISO 17799. 1. Motivation and Objectives Number and severity of attacks against the IT-infrastructure of almost any organization is steadily growing [19]. Additionally, the number of uncovered security threats grows, for example in operating systems. Thus, the organization is under growing risk: intruders are able to attack organizations and might cause * Corresponding author: Dr. Falko Dressler, Dept. of Computer Science 7, University of Erlangen, Martensstr. 3, 91058 Erlangen, Germany; Telephone: +49 9131 85-27914, Email: email@example.com enormous damage. As a result, organizations are likely to loose assets and conclusively to loose money. In order to avoid such loss, organizations try to secure their systems and to save money by installing controls. However, the question arises where to invest and especially how much. Installing very many controls usually leads to an improved security, but to high costs due to installation and maintenance. In opposite, installation of none or not enough controls will lead to large and expensive security incidents, which, in turn, might be also very expensive for the organization. Therefore, there is a growing requirement for an appropriate measure for evaluating the security of an entire organization. Moreover, there is an additional reason measuring the security risks of an organization: security risks usually influence the operational risk of an organization. Due to BASEL II [1], the operational risk of an organization has become an important aspect for loan granting.


Despite significant breakthroughs in understanding, prevention, and treatment of prostate cancer, it still represents the fourth leading cancer in the general population worldwide. The high rate of mortality among prostate cancer patients is clear indication of insufficient efficiency of currently available prostate cancer therapies. Thus, there is a constant demand for new therapies or drugs to treat and prevent this life-threatening disease. Identifying new chemotherapeutic agents with fewer side effects is a major concern for scientists today. In this direction, medicinal herbs are nowadays looked to have great potential to act as chemopreventive agents. One such underutilized potential medicinal herb Asplenium ceterach is highly unexplored in Kashmir region. Therefore, the present investigation was undertaken to investigate the nutraceutical composition, antioxidant activity and preliminary anti-cancerous potential of this medicinal herb. The current study demonstrated aqueous extract of Asplenium ceterach (ACE) to be rich source of nutraceuticals like phenols (465 ± 1.49mg per 100g) and flavonoids (66.34 ± 0.351mg/ 100g) and possess strong antioxidant activity. This preliminary study demonstrated remarkable anti-cancerous activity of AC extract against two prostate cancer cell lines viz., PC3 and LNCaP. This research study provides a scientific basis for exploitation of Asplenium ceterach from Kashmir valley for its use for anti-cancer chemopreventive drug development or as an adjuvant to existing prostate cancer therapies.


Category: Ankle; Arthroscopy; Sports Introduction/Purpose: To provide an overview of the clinical outcomes of arthroscopic procedures used as a treatment strategy for anterior ankle impingement and to determine if gender affects outcomes. Methods: A systematic literature search of the Medline, Embase, and Cochrane databases was performed during June of 2019. The combination of search terms utilized included the following: 'ankle', 'impingement', 'talus', 'osteophyte', 'arthroscopy', 'surgery', 'procedures', and 'treatment'. Two reviewers independently performed data extraction consisting of demographic data, intraoperative arthroscopic data, functional outcome scores, patient satisfaction, complications, return to play, and gender differences. Results: Twenty-eight articles evaluating a total of 1,506 patients were included in this systematic review. Sixty percent (17 of 28) and 14% (4 of 28) of studies assessed anterolateral and anteromedial impingement, respectively. Overall, good to excellent results were reported following arthroscopic treatment in patients with anterior ankle impingement with an average success rate of 81.04%. Eleven studies reported return to sport with an average return to sport of 8 weeks. The most common concomitant pathology found during arthroscopic evaluation included synovitis, osteophytes, meniscoid lesions, and AITFL injury. Four studies (15%) failed to report gender as a demographic variable. Only 7 (25%) studies reported gender analysis with four (57%) studies demonstrating differences when comparing gender outcomes. Female patients have higher rates of traumatic ankle sprains, chondral injury, and chronic ankle instability associated with anterior ankle impingement when compared with male patients. Conclusion: Our systematic review demonstrates that arthroscopic treatment for anterior ankle impingement provides good to excellent functional outcomes, and good return to sports rates in the athletic population. This study underscores that lack of statistical analysis evaluating outcomes comparing male and female populations. Our study does demonstrate that female patients have higher rates of traumatic ankle sprains, chondral injury, and chronic ankle instability associated with anterior ankle impingement when compared with male patients. Therefore, women may benefit from both AMI/ALI resection as well as lateral ankle ligament repair or reconstruction in order to address both impingement and chronic lateral ankle instability.


The presentation summarises the status of the First Generation of instruments for the 10-m Spanish Telescope, GTC (Gran Telescopio CANARIAS). The GTC is planned to have its First Light at the end of 2002, and to be operating at the end of 2003. The management plan at the Project Office, PO, for the procurement of the instruments is presented. Three instruments, covering the whole wavelength range, are in the Preliminary Design Phase: OSIRIS, and imager and multi-object spectrograph in the optical range (0.365-1.050 μm), EMIR, a near-IR (1.0-2.5 μm) multi-object spectrograph and imager and CANARI-CAM, a camera and low resolution spectrograph for the mid-IR (8-26 μm). A general view of the characteristics and design status of these instruments will be presented. The success of the instrumental projects, operating in a queue-schedule mode, will constitute a modest but a powerful tool for the GTC to become an extremely competitive telescope for the Next Century, providing an enormous scientific return to the Spanish Community. The key for this goal is, not only to have competitive instruments within the allocated budget but, overall, to have them on time. Management techniques, like a continuous monitoring of the project drives - scope, schedule and price - and risk analysis are being applied to the instrumental projects from the early phases. The established System Engineering procedures at the PO, like the early definition of the Interface Control Documents, a strict Configuration Control and Quality Assessment are followed in the Project Office and also applies to the contracts with the instrument vendors.


BACKGROUND
To compare the effect of obesity and related risk factors on 10-year mortality in two cohorts of older adults of African descent; one from the United States and one from Nigeria.

METHODS
Study participants were community residents aged 70 or older of African descent living in Indianapolis, Indiana (N = 1,269) or Ibadan, Nigeria (1,197). We compared survival curves between the two cohorts by obesity class and estimated the effect of obesity class on mortality in Cox proportional hazards models controlling for age, gender, alcohol use, and smoking history, and the cardiometabolic biomarkers blood pressure, triglycerides, high-density lipoprotein, low-density lipoprotein, and C-reactive protein.

RESULTS
We found that underweight was associated with an increased risk of death in both the Yoruba (hazards ratio = 1.35, 95% confidence interval: 1.12-1.63) and African American samples (hazards ratio = 2.49, 95% confidence interval: 1.40-4.43) compared with those with normal weight. The overweight and obese participants in both cohorts experienced survival similar to the normal weight participants. Controlling for cardiometabolic biomarkers had little effect on the obesity-specific hazard ratios in either cohort.

CONCLUSIONS
Despite significant differences across these two cohorts in terms of obesity and biomarker levels, overall 10-year survival and obesity class-specific survival were remarkably similar.


Rationale Interstitial lung abnormalities (ILA) are associated with the highest genetic risk locus for IPF; however, the extent to which there is additional overlap with IPF, or unique associations among those with ILA is not known. Objectives To perform a genome-wide association study (GWAS) of ILA. Methods: ILA and the subpleural-predominant subtype were assessed on chest computed tomography (CT) scans in the AGES, COPDGene, Framingham Heart, ECLIPSE, MESA, and SPIROMICS studies. We performed a GWAS of ILA in each cohort and combined the results using a meta-analysis. We assessed for overlapping associations in independent GWASs of IPF. Measurements and Main Results Genome-wide genotyping data were available in 1,699 ILA cases and 10,274 controls. The MUC5B promoter variant rs35705950 was significantly associated with both ILA (p=2.6x10-27) and subpleural ILA (p=1.6x10-29). We discovered novel genome-wide associations near IPO11 (rs6886640, p=3.8x10-8) and FCF1P3 (rs73199442, p=4.8x10-8) with ILA, and HTRE1 (rs7744971, p=4.2x10-8) with subpleural-predominant ILA. These novel associations were not associated with IPF. Of 12 previously reported IPF GWAS loci, 5 (DPP9, DSP, FAM13A, IVD, and MUC5B) were significantly associated (p<0.05/12) with ILA. Conclusions In a GWAS of ILA in six studies, we confirmed the association with a MUC5B promoter variant and found strong evidence for an effect of previously described IPF loci; however, novel ILA associations were not associated with IPF. These findings highlight common and suggest distinct genetically-driven biologic pathways between ILA and IPF.


This study is an investigation on effective risk management with respect to organizations in Nigeria. The objective of the paper is to examine factors militating against effective risk management in organizations. The paper adopted content analysis of library materials, journal publications, internet materials and other documented materials relevant to the subject matter. It was concluded that effective risk management is a proactive approach towards mitigating the impact of threats, maximizing opportunities and optimizing the achievement of objectives. It was recommended that managers of organizations in Nigeria should imbibe and articulate good corporate risk attitude, strong risk culture and clearer risk appetite.


A method for methanol detection by an inexpensive device using a nanomaterial modified by N-methylpolypyrrole (NMPPY) has been developed. Manganese-doped zinc sulfide quantum dots (Mn/ZnS-QDs) were synthesized and then characterized by a fluorescence spectrophotometer to study their spectroscopic properties. Mn/ZnS-QDs were modified with NMPPy and studied by digital-image colorimetry to optimize conditions for methanol detection. A 2 mL of 3000 mg∙L–1 Mn/ZnS-QDs modified with 300 μL of 1000 mg∙L-1 of NMPPy was chosen to be a detecting reagent for methanol determination. Under the optimum conditions, the linear range was found to be 2%v/v to 50%v/v of methanol with R-square of 0.9434 and the sensitivity of 3.569 ´ 10–3 (%v/v)-1, whilst the limit of detection (LOD) was 19.5%v/v. The selectivity of this method was also studied with several solvents; it was proven selective for methanol. Furthermore, a prototype device with simple and inexpensive has been created. The analytical performances were studied; the linearity of methanol detection was found in the range of 20%v/v to 80%v/v with R-square of 0.9918 and the sensitivity of 3.38 ´ 10-3 (%v/v)-1. Finally, the newly developed device was applied to analyze samples of hand sanitizer gel by digital-image colorimetry with acceptable results.


A magnetoresistance random access memory (MRAM) with a guided synthetic antiferromagnet (SAF) and direct writing scheme is presented to reduce the writing time. The MRAM cell includes not only the balanced SAF trilayers but also one more guiding layer, which is weakly exchange-coupled with one of the SAF layers. The two orthogonally oriented digital and word lines are aligned at 45deg with respect to the easy axis of the cell. With the exchange-coupling field from the guiding layer, the MRAM cell can be written directly by the combined field induced by current of the digital and word line. However, the cell cannot be switched by any single field induced by either current due to the balanced SAF structure before saturation. The switching field has been reduced and the writing operation margin has been improved with the use of the exchange-coupling field. Both simulation and the experiments have been carried out to verify this scheme. The write operation margin-H disturb/Hsw of more than 4.3 has been achieved for the magnetic tunnel junction MRAM cell


Dr. Davis reviews the book Cultivating Race: The Expansion of Slavery in Georgia, 1750 - 1860 by Watson W. Dennison.


Double variational method can be used for solving the problem of scattering plane monochromatic wave by an ideally conducting periodic (corrugated) surface. Numerical realization of this method shows that it is more effective than widely used method of physical optics, offering promise as a tool for study of physical phenomena that occur when wave beams or pulses are diffracted by periodic surfaces.


Pregnant women, like everyone else, travel internationally for business and pleasure. However, since preterm labor is experienced in 8-30% of all pregnancies, a significant number of women are admitted to hospitals with signs and symptoms of threatening preterm delivery while traveling abroad. Repatriation requests represent a difficult scenario for insurance and assistance companies as well as for physicians in referring and admitting hospitals. Here, we present a comprehensive literature review and an analysis of possibilities and limitations when transporting pregnant women on international, long-distance fixed-wing Air Ambulance. While no Air Ambulance environment can provide the necessary safety for mother and baby during a delivery in-flight, available data suggests that in-flight deliveries can be successfully avoided. In this review, we propose a risk based approach, taking factors such as locally available perinatal services, transport distance and routing, presence or absence of chorioamnionitis and contractions, cervical length and cervical dilatation as well as molecular markers (fFN, PAMG-1, phIGFBP-1), if locally available, into account. wing Abbreviations: CAMTS: Commission on Accreditation of Medical Transport Systems, COXII: Cyclooxygenase-2, EURAMI: European Aeromedical Institute, fFN: fetal Fibronectin, GA: Gestational Age, HFO: High Frequency Oscillation, ICU: Intensive Care Unit, iNO: inhaled Nitric Monoxide, PAMG-1: Placental alpha-microglobulin-1, phIGFBP-1: Cervical phosphorylated insuline-like growth factor binding protein-1, PROM: Premature Rupture of Membranes, RCT: Randomized Controlled Trial, RFDS: Royal Flying Doctor Service, ROM: Rupture of Membranes.


This article examines the cycle of technological implementation and application in the fuel and energy industry, analyzes technological security in its various sectors, and identifies the issues complicating the development of Russian technology (import substitution) at the current stage.


The solubilization of a new autoantigen detected on swollen spermheads was described. This new autoantigen was detected when human spermatozoal heads were treated with trypsin or dithiothreitol and trypsin. Sera from 56 men 29 women and 14 children were tested by the indirect immunofluorescence test for the presence of antibodies against swollen spermheads. A significantly larger number of positive sera from men was found in the group with a high spermagglutination titer (a reading of more than 512) than in the groups with a titer between 16 and 256 (p less than .04). Sera from women and children revealed no spermagglutinating antibodies or swollen spermatozoa even if spermagglutinins were present. Only antihuman immunoglobulin G (IgG) gave fluorescence when sera from 3 men which contained antibodies against spermhead antigen were tested for IgG IgA and IgM. Deoxyribonuclease was used to solubilize spermheads which were then analyzed for autoantigens by immunofluoresence-inhibition or spermagglutination-inhibition. Spermagglutinating antibodies were not absorbed; however antibodies against swollen spermheads the front part of the acrosome and the postnuclear region were absorbed with the solubilized preparation.


In the binary context, a consecutive- k -out-of- n system is failed if and only if at least k consecutive components are failed. In this paper we propose definitions of the multi-state consecutive- k -out-of- n :F and G systems. In the proposed definition, both the system and its components may be in one of M + 1 possible states: 0, 1,..., and M . The dual relationship between the proposed systems is identified. The concept of dominance is used to characterize the properties of multi-state systems. The concepts of duality, equivalence, and dominance are used in evaluation of system state distribution of multi-state consecutive- k -out-of- n systems. An algorithm is provided for evaluating system state distribution of decreasing multi-state consecutive- k -out-of- n :F systems. Another algorithm is provided to bound system state distribution of multi-state consecutive- k -out-of- n :F and G systems. Several examples are included to illustrate the proposed definitions, concepts, and algorithms.


The invention discloses a manufacturing method of a poultry feed additive containing traditional Chinese medicinal activity probiotics, comprising the following steps of: carrying out single stain quantity enlarge culture on the original strain of every poultry activity probiotic; mixing equal weight first-level seed liquids of each poultry activity probiotic, inoculating to a medium in a seed jar for mixing and culturing of a plurality of strains, and inoculating into a traditional Chinese medicinal liquid medium for the fermentation of the traditional Chinese medicine so as to prepare the poultry feed additive containing traditional Chinese medicinal activity probiotics. The embodiment provided by the invention can be implemented to greatly raise the strain activity of activity probiotics in the poultry feed additive and the colonization performance in intestinal tract, make the prepared poultry feed additive rich in traditional Chinese medicinal components and make the active components with pharmacological effects in the traditional Chinese medicinal components to fully perform, so as to raise the poultry feed additive's body strengthening and disease treating performance and growth promotion performance. Furthermore, antibiotics are completely replaced.


Generally, cogging torque derives from motor using permanent magnet such as interior permanent magnet synchronous motor (IPMSM) and surface permanent magent synchronous motor (SPMSM). The cogging torque works for smoothness in rotation of the rotor, but it is a kind of root cause mechanical vibration and acoustic noise. Consequently, cogging torque must be reduced by all manner of means. There are various methods to reduce the cogging torque, but this paper deals with two ways in the IPMSM. One is tapping the rotor and the other is design of barrier shape. Besides, this paper proposes best design of the IPMSM to reduce cogging torque, and the analysis of cogging torque by using FEM is compared with experimental results to verify.


Human body motion analysis is an important technology which modem bio-mechanics combines with computer vision and has been widely used in intelligent control, human computer interaction, motion analysis and virtual reality and other fields. In which the moving human body detection is the most important part of the human body motion analysis, the purpose is to detect the moving human body from the background image in video sequences, and for the follow-up treatment such as the target classification, the human body tracking and behavior understanding, its effective detection plays a very important role. According to the result of moving object detection research on video sequences. This paper proposes a new method to detect moving object based on background subtraction. First of all, we establish a reliable background updating model based on statistical and use a dynamic optimization threshold method to obtain a more complete moving object. And then, morphological filtering is introduced to eliminate the noise and solve the background disturbance problem. At last, contour projection analysis is combined with the shape analysis to remove the effect of shadow; the moving human bodies are accurately and reliably detected. The experiment results show that the proposed method runs quickly, accurately and fits for the real-time detection. KeywordsVideo surveillance, Motion detection, Background Separation, Frame Separation. Journal of Signal and Image Processing ISSN: 0976-8882 & E-ISSN: 0976-8890, Volume 3, Issue 3, 2012 Introduction Human body motion analysis is an important technology which modem bio-mechanics combines with computer vision and has been widely used in intelligent control, human computer interaction, motion analysis and virtual reality and other fields [1]. In which the moving human body detection is the most important part of the human body motion analysis, the purpose is to detect the moving human body from the background image in video sequences, and for the follow-up treatment such as the target classification, the human body tracking and behavior understanding, its effective detection plays a very important role. Currently, methods used in moving object detection are mainly the frame subtraction method, the background subtraction method and the optical flow method. Frame subtraction method is through the difference between two Consecutive images to determine the presence of moving objects. Its calculation is simple and easy to implement. For a variety of dynamic environments, it has strong adaptability, but it is generally difficult to obtain a complete outline of moving Object, liable to appear the empty phenomenon, as a result the detection of moving object is not accurate. Optical flow method is to calculate the image optical flow field, and do clustering processing according to the optical flow Distribution characteristics of image. This method can get the complete movement information and detect the moving object. From the background better, however, a large quantity of calculation, sensitivity to noise, poor anti-noise performance, make it not suitable for real-time demanding occasions. The background subtraction method is to use the difference method of the current image and background image to detect moving objects, with simple algorithm, but very sensitive to the changes in the external Citation: Pande R.P., et al. (2012) Detection Of Moving Object With The Help Of Motion Detection Alarm System In Video Survelliance. Journal of Signal and Image Processing, ISSN: 0976-8882 & E-ISSN: 0976-8890, Volume 3, Issue 3, 2012, pp.-118-121. Copyright: Copyright©2012 Pande R.P., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


We study monomial ideals, always given by a unique monomial, like a reasonable first step to estimate in general the number of blow ups of Villamayor's algorithm of resolution of singu-larities. To resolve a monomial ideal < X a 1


Objective To compare the efficacy and safety of three different methods of laparoscopic common bile duct exploration (LCBDE).Methods The clinical data of patients with LCBDE treated in our hospital by the same surgeon from January 2010 to December 2012 were retrospectively analyzed.These patients were divided into three groups according to the 3 surgical methods:Group A:15 patients were treated with laparoscopic transcystic common bile duct exploration (LTCBDE).Group B:85 patients were treated with laparoscopic common bile duct exploration followed by primary duct closure (LCBDEPDC).Group C:20 patients were treated with laparoscopic common bile duct exploration and T tube drainage (LCBDE-TD).The study measured the TBIL,inner diameter of common bile duct,costs,length of operation,postoperative hospital stay,peritoneal drainage time,and operation-related complications.Results The operations were successfully carried out in the 3 groups of patients.When compared with group C,group A and group B had significantly shorter operative time,shorter postoperative hospital stay,shorter peritoneal drainage time,lower hospital costs,and earlier return to work (P<0.05).The only significant difference between group A and group B was the peritoneal drainage time.There was no significant difference in the incidences of postoperative complications between the 3 groups (P>0.05).Conclusions The three different methods of LCBDE had their own indications.LTCBDE was better than primary suture,and LCBDEPDC was better than T-tube drainage after laparoscopic common bile duct exploration.

Key words:
Cholelithiasis;  Cholecystectomy, laparoscopic


Recently, explainable artificial intelligence has received considerable attention. Most existing studies are focusing on the tasks of CNNs-based image classification and RNNs-based time series analysis. In this paper, we pay attention to the more complicated spatiotemporal predictive learning task (SPLT), where both the spatial and temporal information play important roles. To explain the internal mechanism of spatiotemporal prediction models, we propose a comprehensive analysis method. Specifically, with a typical encoder-decoder framework, we focus on two core issues of SPLT: image generation and spatiotemporal dynamics. For the first issue, we develop a quantitative channel perturbation method to explore the importance of features to prediction. Furthermore, we propose a technique called the synthesis of multiple independent components to analyze how these features generate the prediction. According to the experimental results, the coarse- and fine-grained synthesis (CFGS) mechanism is drawn for image generation in SPLT. For the second issue, we propose a state decomposition technique and a state expansion technique to disentangle coupled signals in the spatiotemporal dynamical system. This helps us to explore the mechanism of forming motion. Moreover, to diagnose the movement of a particular region during analysis, we propose a fluorescent stamp-based technique. By observing extensive experimental results, we summarize a collaboration mechanism to explain how the motion is formed in SPLT, namely, the extending the present and erasing the past (EPEP) mechanism. To the best of our knowledge, this is the first work to interpret the internal mechanism of SPLT models.


The work derives the quantum evolution in a fluctuating vacuum by introducing the related (dark) mass density noise into the Madelung quantum hydrodynamic model. The paper shows that the classical dynamics can spontaneously emerge on the cosmological scale allowing the realization of the classical system-environment super system. The work shows that the dark matter-induced noise is not spatially white and owns a well defined correlation function with the intrinsic vacuum physical length given by the De Broglie one. By departing from the quantum mechanics (the deterministic limit of the theory) in the case of microscopic systems whose dimension is much smaller than the De Broglie length, the model leads to the Langevin-Schrodinger equation whose friction coefficient is not constant. The derivation puts in evidence the range of application of the Langevin-Schrodinger equation and the approximations inherent to its foundation. Increasing the physical length of the system description, the classical physics can be achieved when the scale of the problem is much bigger both than the De Broglie length and the quantum potential range of interaction. The long-distance characteristics as well as the range of interaction of the non-local quantum potential are derived and analyzed in order to have a coarse-grained large-scale description. The process of measurement, in the large-scale classical limit, satisfies the minimum uncertainty conditions if interactions and information do not travel faster than the light speed, reconciling the quantum entanglement with the relativistic macroscopic locality.


The requirements of modern times and particularly the last five years or so, have imposed a rapidly developing technology in the field of hydraulic automation systems. The systems sector increasingly develop their fields of application, be it simple or hydraulic circuits for modern hydraulic automation circuits. In the systems with automated processes, the systems industry with the help of a Programmable Logical Controller only recently has begun to make its appearance. In this thesis, the feasibility study shows a hydraulic system with the aid of the PLC, in order to optimize the automatic control system and the position accuracy of two hydraulic pistons. Moreover, it describes the properties of the hydraulic system, its structural components and the detailed functional description of Programmable Logic Controller. Finally, the work ends with the recording of the findings of the use of this integrated hydraulic circuit.


In order to improve the doubly-fed wind turbine low voltage ride through capability,this paper adds a supercapacitor circuit to the DC-link.The coordination control of the supercapacitor and converter can not only reduce the torque imbalance during the failure,extending the unit ride-through time,but also inject a certain amount of reactive power into grid to support the system voltage recovery.


Abstract In the labour brokerage state of systematic recruitment and export for the maximisation of labour, development, and profit, the Philippines continues to simultaneously fashion migrant workers as temporary, yet heroic and sacrificial. As the largest migrant-sending country in Southeast Asia and the third largest remittance recipient in Asia, the Philippines' discourse of migrants as modern-day heroes and martyrs reveals the interplay of nationalist myths and cultural values, alongside the neoliberal favouring of finance and flexible labour, to craft filial migrants and celebrate mobile, capitalist subjects over migrants' welfare and well-being. The article explores the contemporaneous institutionalisation of migrant labour and migrants' institutionalised uncertainty lived every day to investigate how this profound precariousness in the Philippines is perpetuated historically to shape the resilience and realities of migrants and their left-behind children today. Drawing from news reports and films on migrant lives and ethnographic fieldwork in the Philippines, this article considers how the formation and deployment of overseas Filipino workers (OFWs) turns from a focus on sustaining the nation to supporting migrant families and developing translocal communities. Through this examination, the paper seeks to uncover who profits and is indebted from the precarity created and sustained by the larger economic system built on transnational labour migration.


Abstract Love of money (LOM) signifies self-interest. At first glance, it is incompatible with the altruistic notion of public service motivation (PSM). A recent study based in China, however, indicated that LOM can interact with PSM to enhance job satisfaction. Driven by the conjecture that the finding is reflective of China's unique circumstances and therefore cannot be replicated in other contexts, the present study re-examined this relationship. By testing data collected in Taiwan, it was found: (1) LOM is negatively correlated with PSM; (2) the positive relationship between PSM and job satisfaction is more pronounced when LOM is low; and (3) this moderating effect occurs only when LOM becomes a potent work motive. These findings lend support to the incompatibility between LOM and PSM and also clarify the different roles of money attitudes that have implications for influencing work motivation and behavior in the public workplace.


A new two dimensional, fast, analog, electrically addressable, silicon based membrane spatial light modulator (SLM) was developed for optical information processing applications. Coherent light reflected from the mirror elements is phase modulated producing an optical Fourier transform of an analog signal input to the device. The DMD architecture and operating parameters related to this application are presented. A model is developed that describes the optical Fourier transform properties of the DMD.


Reducing the size of inorganic materials to the nanometer scale is expected to produce unique electric, photonic, and magnetic functions, [1–3] and assembling and patterning nano-structures makes them potentially useful for many applications. Although controlling assembly and patterning has remained a significant challenge, the use of self-assembled organic materials as templates is one of the most appropriate bottom-up fabrication procedures for nanoscale devices. [4,5] Deoxyribonucleic acid (DNA) is one of the appropriate biopolymer templates that can be used to construct defined inorganic materials. Highly selective base-pair interactions between complementary single-strand DNA chains have been used for nanoassembly. For example, gold nanoparticles with single-strand DNA molecules immobilized on their surface can reversibly assemble, [6,7] and a building-up process using complementary DNA strands enables the creation of artificial nanostructured templates for nanoparticle assembly. [8–10] Native double-helical DNA is also known to directly interact with metal ions and their complexes. The binding of metal ions or complexes to DNA has been utilized for DNA metallization to form nanowires that can be used to wire electronic components into nanoelectronic circuits. Several metals, such as Au, [11,12] Ag, [13,14] Pd, [15–17] Pt, [17] and Cu, [18] have been deposited on DNA chains, and the electrical conductivity of some metal-deposited DNA nanowires has been measured. [13,16] In this study, we have prepared metal–DNA nanohybrid structures by using a combination of metallization and DNA


Objective
To evaluate the effectiveness of two kinds of down regulation protocols used in vitro fertilization embryo transfer( IVF-ET) in infertile patients with endometriosis(EMs).

Methods
CBM disc, Wan fang, CNKI, VIP, Pubmed, PML, FMJS were searched for randomized controlled trails(RCTs) on the comparison between prolonged protocol and long protocol in IVF-ET in infertility patients with EMs. The bibliography of the included studies were searched, too. The duration of search was form January 2000 to June 2012.The quality of the included was evaluated by three evaluators. For the homogeneous studies we performed Meta analysis. The extracted data were analyzed by RenMan 5.1.

Results
Seven literatures with 593 participants were selected for Meta analysis based on our including standards. Which involving 219 cases with prolonged protocol and 374 cases with long protocol of gonadotrophins(Gn). Meta analyses showed that prolonged protocol compared with long protocol cancellation rates were no significant difference in two groups at WMD=0.69 and 95%CI: 0.32-1.51; gonadotrophin releasing hormone analogue(GnRHa) stimulation durations were no significant difference in two groups at WMD=0.12 and 95% CI: -0.04-0.28; doses of GnRHa in prolonged protocol group were higher at the WMD=-311.25 and 95%CI: 6.43-616.08, the differences were statistically significant; the number of oocytes retrieved was no significant difference between two group at the WMD=-0.65 and 95%CI: -1.76-0.47(P>0.05); the differences were statistically significant serum E2 levels on the day of human chorionic gonadotrophin(hCG) administration was no significant difference in two groups at the WMD=-499.71 and 95%CI: -1171.02-171.60(P>0.05); clinical pregnancy rates in prolonged protocol group were slightly higher at the WMD=2.23 and 95%CI: 1.49-3.33, the differences were statistically significant(P 0.05).

Conclusions
In EMs patients with infertility IVF-ET treatment, compared with long protocol, the prolonged protocol can obviously increase the clinical pregnancy rate, so the IVF-ET may be an ideal choice for EMs patients with infertility. Because the including trails exist insufficiency on quality and quantity as well as the methodology difference, suggested that this research conclusion only serve as the reference of the clinical analysis, need reevaluation and renew unceasingly.

Key words:
endometriosis; in vitro fertilization embryo transfer; prolonged/ultralong protocol; long protocol; Mate analysis


The present invention relates to an insulating member for incorporation in the ring hole of the ring core (2). The insulating member is, for forming a separate winding space, and separation mechanism for connecting the spacer (102, 102 ') (1) is provided. At that time, the separation mechanism (1) has at least one separating web (11), the first spacer (102) is disposed at its end. In this case, the width W of the separating webs is smaller than the width b of the spacer (102).


School nurses play a critical role in the provision of mental health services in the school environment and are valuable members of the coordinated student mental health team. They possess expertise to navigate in today's complicated educational and health care systems, and it is estimated that school nurses spend 33% of their time addressing student mental health issues. Despite their role and expertise, school nurses are often not recognized as part of the school mental health team and, thus, their role in student mental health care and the full collaboration and coordination with other education and mental health professionals in the school has yet to be fully realized. This article reviews school nurse mental health expertise, models of mental health service provision, and current mental health practices as reported by national stakeholders. In addition, it highlights school nurse barriers and additional training needs related to student mental health care and provides concrete recommendations for building strong collaborations between school nurses and other education and mental health professionals to support student mental health.


Background: Immunotherapy has become a new standard in the care of patients with head and neck squamous cell carcinoma (HNSCC). A number of patients' tumors do not respond to this treatment, and recent studies have established an immunomodulatory role for the ATR-CHK1 signaling axis in the tumor microenvironment and the specific effects of ATR inhibitors in stimulating an innate immune response. Therefore, we have assessed the efficacy of the novel ATR inhibitor (AZD6738) as monotherapy and in combination with anti-PD-1 antibody in a syngeneic mouse model of HNSCC. Methods: In vitro clonogenic survival assays were used to evaluate the IC50 values of the ATR inhibitor AZD6738 in syngeneic MOC1, MOC2 and ROC1 mouse HNSCC cell lines. Western blotting and ATR shRNA knock-down strategies were performed to examine drug specificity and dissect molecular mechanisms. An orthotopic syngeneic mouse model of head and neck cancer was used to explore in vivo efficacy of the combination treatment. Immune profiling on tumor tissues obtained following drug treatment was assessed by immunohistochemistry and multiplex immunofluorescence analyses. Conditioned medium (CM) and bone marrow (BM) cells were obtained and subjected to flow cytometric analyses to assess myeloid cell phenotypic and functional markers. Coculture of the BM cells with mouse splenic T cells was also conducted to measure suppression of T cell activation and proliferation. Results: MOC1, MOC2 and ROC1 cell lines treated in vitro with various concentrations of single agent AZD6738 showed an IC50 value of 0.18-0.625 µmol/L. Combination of AZD3867 and anti-PD-1 antibody significantly reduced tumor growth and prolonged survival in mice injected with MOC1 cells orthotopically in the oral tongue compared to control and other treatment groups (P <0.0001 and P = 0.001, respectively). Combination therapy was well-tolerated and no weight loss was observed in mice. The CD4+T, CD8+ T lymphocytes and NK cells were elevated in mice tumors treated with combination of the drug compared to other treatment groups. Additionally, the inhibitory FoxP3+ Treg cells were significantly reduced (P = 0007) in mice tumors following the combination treatment. The BM cells exposed to CM collected from ATR shRNA MOC1/2 cell lines, and those treated ex-vivo with AZD6738 alone demonstrated decreased arginase-1 expression and a reduced capacity to inhibit T cell activation and proliferation relative to control groups. These findings suggest a role for ATR in modulating myeloid derived suppressive cell (MDSC) function. Mechanistically, we demonstrated that the ATR inhibition caused DNA damage response leading to cGAS/STING pathway activation associated with decreased STAT3 phosphorylation in vitro and in vivo in syngeneic head and neck cancer cells. Conclusion: In this study, we demonstrate that the immunogenic effects of AZD6738 are mediated by cytotoxic T cells as well as innate immunity. The combination of AZD6738 and anti-PD-1 warrants further exploration as a novel combination therapy for HNSCC.
 Citation Format: Abdullah A. Osman, Fabio H. B. da Costa, Adewale A. Adebayo, Mason D. Bartels, Tongxin Xie, Moran Amit, Mutsuki Kawabe, Roberto Rangel, Mitchell J. Frederick, Vlad Sandulache, Andrew G. Sikora, Jeffrey N. Myers. Inhibition of ATR as a therapeutic strategy to enhance immunotherapy in head and neck cancer [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research; 2023 Jul 7-8; Montreal, QC, Canada. Philadelphia (PA): AACR; Clin Cancer Res 2023;29(18_Suppl):Abstract nr PO-085.


The present work examines the effect of temperature-dependent fluid density on the reactive couple stress fluid flowing steadily in a vertical channel saturated with porous materials. The thermal effect gave rise to a linked differential system of equations. In the dimensionless form, the boundary-valued problems (BVP) are uncoupled and solved by using Adomian decomposition method (ADM). The solutions are used to obtain expressions for entropy generation and Bejan heat irreversibility number in the porous medium. The relevant fluid parameters are varied and discussed physically. The present result shows good agreement with the previously obtained result when buoyancy force is neglected. The present study is relevantal in the thermal treatment of combustible fluids in chemical and petro-chemical engineering.


Objective:To assess the reporting quality of randomized controlled trials(RCTs)published in Chinese Journal of Oncology with CONSORT statement.Methods:RCTs published in Chinese Journal of Oncology were searched and downloaded from three databases,including CNKI,CBMdisc and VIP database.All of the RCTs were evaluated with the revised CONSORT statement.Results:From 75 papers were included.Regarding to the background,intervention,objectives,recruitment and demographic of participants,and adverse events,the papers had reported in details.However,as to title and abstract,the implementation of randomization and blinding,the estimation of sample size,the description of statistic method,use of participant flow chart,and discussion about results,and there existed considerable shortcomings.Conclusion:Generally,the reporting quality of RCTs in Chinese Journal of Oncology was poor,standardized reporting of RCTs compliance with CONSORT statement was advised.


— This article discusses whether iPerf can be used as an effective tool for wired and wireless LAN throughput estimation. The potential advantages of using iPerf in comparison to FTP are discussed. Finally, the article presents the throughput measurement results obtained with FTP, iPerf2 and iPerf3 in a simple experimental network.


Silicone implants are largely used both in aesthetic and reconstructive medicine, thanks to their recognized biocompatibility. The damage of breast prostheses as a consequence of accidental impacts, is however one of the possible critical situations in their use. The behaviour of silicone breast prostheses in case of accidental impacts, for example in a car accident, is studied by experimental crash tests, accounting for the action exerted by seat belts during impact. Possible effects of aging over the mechanical response of the implants are also considered and approached. Static compression tests performed after long term aging indicate a possible degradation of prosthesis mechanical performance, which should be considered when analysing the possible consequences of an accidental damage.


10 cases with separation of the lumbar vertebral rims, 5 of the anterior separation and 5 of the posterior one, were radiologically and therapeutically discussed. Furthermore, the mechanism of the separation was dynamically presumed.All patients except one showed no response to conservative treatment. 5 patients of the anterior separation and one of the posterior separation had anterior fusion. 4 patients of the posterior separation had extensive laminectomy plus excision of bony fragment. Consequently, fusion cases oftained complete relief of pain whereas laminectomy cases remained persisting low back pain due to intervertebral instability.Computed tomogram clearly revealed common characteristics in both anterior and posterior separation.Anterior separation may be produced in the anteriorsuperior rim of L5. On the other hand, posterior separation in the posterior-inferior rim of L4.Concerning the mechaism of the separation, in flexion, shearing stress acts so as to split obliquely the posterior rim. On the other hand, in extension, the stress acts so as to split the anterior rim. Tensile stress acting on the rims may pull out the anterior or posterior rim. Compressive stress acts so as to push the nucleus pulposus into the split.


In this paper, a FIR artificial neural network (ANN) is applied as a nonlinear predictor to predict time series signal for speeding up the FDTD simulations. The computational time has been reduced to more than 87% while maintaining the same accuracy that was published using FDTD


Purpose: To determine alpha/beta (α/ß) values of arteriovenous malformations (AVM), meningiomas, acoustic neuromas (AN), and the optic chiasma using clinical data. Methods and materials: Data of dose/fractionation schedules form the literature, iso-effective for a specific clinical outcome, were analysed using the Fraction Equivalent plot (FE) method and the Tucker method. Established safe dose/fractionation schedules for the optic chiasma were used to determine its α/ß value. Results: With the FE plot method, an alpha/beta value of 3.76 Gray (Gy) (95% confidence level [CL]: 2.8–4.6 Gy) for meningiomas, 2.4 Gy (95% CL: 0.8–3.9 Gy) for acoustic neuroma, and 14.7 Gy (95% CL: 3.8–25.7 Gy) for arteriovenous malformations were determined. The respective alpha/beta values using the Tucker method were 3.3 Gy (95%CL: 2.2–6.8 Gy), 1.77 Gy (95%CL: 1.3–3.0 Gy) and −57 Gy (95%CL: −79.6 to –35.2 Gy). No meaningful α/ß values could be determined for the optic chiasma. Conclusion: Acoustic neuromas with a low α/ß value would show no lesion intrinsic benefit from fractionation. Meningiomas probably benefit from a hypofractionated schedule. The high α/ß value for AVM can be explained but needs further research. Fractionation versus radiosurgery can be considered when the primary objective is to avoid normal tissue damage.


Aliphatic ionic liquid is a quaternary ammonium salt represented by the formula (1), an organic solvent, in a non-aqueous electrolyte lithium secondary battery electrolyte solution containing a lithium salt represented by the formula (2), organic the solvent is non-aqueous electrolyte lithium secondary battery electrolyte, characterized in that it contains 1 to 5 wt% vinylene Capo sulfonate with the electrolytic solution, and lithium secondary battery using the same.


This article verifies that hadith of Prophet Muhammad SAW. do not limit someone's wealth amount (results) from a business activity, but limit how method (process) to acquire (result) of a business activity. It indicates that in business activity, hadis of Prophet Muhammad SAW. put more emphasis in importance of process (business ethics) compared to result, in order that there is none who would do evil deed or there is none who would suffers evil deed. This article shows that process of a business activity shall be based on business ethics. Business ethics are gathered from guideline from the Prophet Muhammad SAW. emphasized on two important things; firstly, conducting business activity with reasonable business behavior, secondly, avoiding disgraced business behavior. The business ethics have been practiced by Prophet Muhammad SAW. in conducting business activities before his appointment as Prophet. The main source of this study is texts (the Prophet's utterance) that contained in (hadis books) Sahih al-Bukhari and Sahih Muslim. Beside of that, in order to make more deeper comprehension on those texts, supporting sources are used such as syarah al-hadith book and fiqh books. In order to read those texts are taken thematically (maudu'iy) and also to be enriched by theories and methodologies from other disciplines such as history.


The "demographic time bomb" will have implications for all industries, especially in the recruitment of graduates. This situation is explored with reference to the hotel and catering industry in the UK. Research carried out into the job opportunities for graduates in this sector of industry is reported with regard to the types of job package offered; training; levels of responsibility and career prospects; salary and fringe benefits. It was found that the packages offered exhibit similarities and differences when compared with those offered by other industries and concludes that the present situation in the hotel and catering industry may have arisen from a failure to regard itself as competing in the wider graduate labour market.


Results from two field studies are reported: a quasi-experiment of changing from 60—64 inch to 36—42 inch partition heights at a multi-national corporation, and a comparison of two office areas at a global manufacturer. In the first study, both control and experimental participants endured moving, but only the experimental group experienced any change in partition height. A quantitative, subjective survey provided work environment ratings before, immediately after, and six months after the change. The results show that in general, this was a negative change for users, although some non-significant trends suggested that-defined at the group level-one or two outcomes may have been positive. Using a much more extensive instrument, the second study found several differences in occupant ratings of workplace design as a function of differences in the physical environments. A framework is outlined for interpreting these results in terms of individual (i.e., privacy) and group (i.e., communication) needs.


Abstract The temporal-analysis-of-products approach was used to study the mechanism of the oxidative dehydrogenation of methanol over an unsupported polycrystalline silver catalyst. Pulse experiments revealed a distinct influence of the state of the silver surface on the adsorption of oxygen and on reactivity toward methanol. The surface-embedded oxygen species O γ , which is stable at high temperatures, was found to provide a highly selective reaction pathway for the oxidation of methanol to formaldehyde above 550 K. A comparison of the pulse responses of formaldehyde, water, and hydrogen to methanol pulses showed that water is a primary gas-phase product and that only small amounts of hydrogen are formed. Furthermore, it was found that the O γ species is not active in the oxidation of hydrogen or carbon monoxide. In contrast, the much more active adsorbed oxygen species O α was observed to be involved in the nonselective deep oxidation of methanol at lower temperatures, yielding carbon dioxide at high coverages. However, at low coverages O α also causes the selective formation of formaldehyde.


ABSTRACT The extension principle is always used to fuzzify the crisp functions to obtain the fuzzy functions in which the α-level sets of fuzzy sets are involved in the calculation. In this paper, we shall consider the concepts of upper and lower α-level sets of fuzzy sets. On the other hand, we shall establish the so-called dual extension principle using the concept of dual fuzzy set, which can also be used to fuzzify the crisp function into fuzzy functions. This kind of technique can also be called the dual fuzzification. The benefit of this paper is to provide another technique called dual fuzzification to fuzzify the crisp function into fuzzy functions. The relationship between the fuzzified function using the extension principle and the dual-fuzzified function using the dual extension principle will be established in this paper.


Mesenchymal stem cells(MSCs) are multipotent stem cells derived from the mesoderm, which have ability to differentiate into osteoblasts, chondrocytes and adipocytes. In this experiment, the effects of cyclopamine(CPA), a specific inhibitor of hedgehog signaling pathway, on cell division cycle and adipogenic induction and osteogenic induction of bovine(Bos taurus) adipose mesenchymal stem cells(AMSCs) werestudied. After isolation and identification of AMSCs, CPA was used to treat AMSCs, then effects of CPA on cell cycle and adipocyte differentiation and osteoblast differentiation associated gene expressions were investigated using flow cytometry and Real- time PCR. The results indicated that treatment of AMSCs with CPA at different concentrations affected cell cycle progression in a dose-dependent manner. CPA resulted in cells arrested at G0/G1 stages. After adipogenic induction and osteogenic induction, no obvious morphological differences was observed in the formation of adipocytes and osteoblasts. However, the Real- time PCR detections of the induced cells showed that both peroxisome proliferator- activated receptorγ(PPARγ, critical adipogenic gene) and runt-related transcription factor 2(Runx, critical osteogenic gene) were significantly changed during adipogenic induction or osteogenic induction. PPARγ expression was significantly increased after 4 d treatment compared to the control(P0.01), Runx expression was lower in treatment group than the control(P0.01). These results suggested CPA induced AMSCs arrested at G0/G1 stages and CPA treatments of AMSCs affected adipogenic and osteogenic induction in gene expression level. This experiment provides a basis for the study of hedgehog signaling pathway in AMSCs proliferation and differentiation.


Automatic Modulation Recognition (AMR) is of great significance in civil and military applications. Cumulant-based recognition is one of the effective methods for AMR. However, different from that in conventional SISO systems., Cumulant-based AMR in space division multiplexing MIMO systems faces the problem of lower recognition rate since the statistical characteristics of signals are different in these systems. In order to solve this problem., we propose to adopt auto-encoding network (AEN) as the data dimension reduction algorithm and artificial neural network (ANN) as the classifier of several kinds of digital modulation signals in MIMO system. In our simulations., the proposed scheme is used to classify five types digital modulation signals., which are 2PSK., 4PSK., 8PSK., 16QAM., 32QAM. Simulation results indicate that the proposed method will realize substantially higher recognition rate compared with direct classification by cumulants.


Mechanical behavior of unreinforced masonry wall is analyzed by commercial finite element software ANSYS 8.0 with different modeling methods.The results are compared with those from the experiments.The results show that the whole-stratified model can be well used to analyze the compression behavior of unreinforced masonry wall with proper modeling.The work done is helpful to find out an effective method for the numerical simulation on the structures alike.


Received: Jan 09, 2017 Accepted: Feb 27, 2018 Published Online: Mar 10, 2018 Journal: Journal of Nanomedicine Publisher: MedDocs Publishers LLC Online edition: http://meddocsonline.org/ Copyright: ©Malinski T (2018). This Article is distributed under the terms of Creative Commons Attribution 4.0 international License *Corresponding Author(s): Tadeusz Malinski, Department of Chemistry and Biochemistry, Nanomedical Research Laboratory, Ohio University, USA


Under the background of being short of including technology and other resources,some of high-tech firms of Zhejiang implement "go out" strategy spontaneously,by the practice of knowledge acquisition abroad,they achieve the goal of upgrading or ameliorating in the global value chain.Through the research of theory and interview,we construct the research model of "antecedents-knowledge acquisition abroad-performance outcomes".On the level of RD team's of the high-tech firm as the knowledge seeker,we confirm that international entrepreneurship,global competence and oversea network have the active impact on the regard of invest,behavior and endeavor of knowledge acquisition abroad,and on the innovation and the export performance of the firms.


For scientific planting of Rheum rhaponticum L.,taking seeds of Rheum rhaponticum L.as experimental material,the effect of different concentrations of Zn2+(0,20,50,100,150,200,500 and 700mg·L-1)on seeds germination and seedling growth of Rheum rhaponticum L.was studied.The results indicated that all of the data related to germination firstly rose and then dropped with the increasing of Zn2+concentration.The germination potential,germination rate and germination index were up to the maximum value by using100mg·L-1 Zn2+concentration,while the conductivity was the lowest.Seeding root length,stem length and chlorophyll content decreased with the concentration of Zn2+increased.The results showed that although appropriate amount of Zn2+could promote the germination of seeds,but the seeding root length,stem length and chlorophyll content had been inhibited to a certain degree.


Polarization dependence is a major factor of consideration in the design of optical waveguide devices for applications in optical fiber transmission systems. In many cases, the polarization-dependence problem can be solved by using waveguides with zero modal birefringence. In this paper, theoretical results are presented to show how zero- birefringence waveguides can be designed from various waveguide geometries. The waveguides considered in this paper include strip waveguides, rib waveguides, waveguides, strip-loaded waveguides, and multiple-quantum-well waveguides, which are of particular importance in the construction of semiconductor-based photonic integrated circuits. The design of polarization-insensitive directional couplers with rib waveguides is also discussed.


The geometric and electronic properties of C 58 Si 2 are studied by using density functional theory at BLYP and B3LYP level respectively with 6-311G basis sets. The geometric structure with which the two Si atoms are located at the diagonal positions of a hexagonal ring (called C 58 Si 2-6 below) is 0.11 eV lower in energy than that with which the two Si atoms are located at the diagonal positions of a pentagonal ring (called C 58 Si 2-5 below). C 58 Si 2-6 can keep the geometry of C 60 except for the region near Si atoms. The degeneracy of the energy levels is removed because of Cs symmetry and the energy gap between HOMO-LUMO is smaller than that of C 60 . Each Si atom loses 1.122 e, which is mainly transferred to the three neighboring C atoms. It makes the Si—C bonds polarized and increases the binding energy.


Many magnetic equilibrium states and phase transitions are characterized by fluctuations. Such magnetic fluctuation can, in principle, be detected with scattering-based x-ray photon correlation spectroscopy (XPCS). However, in the established approach of XPCS, the magnetic scattering signal is quadratic in the magnetic scattering cross section, which results not only in often prohibitively small signals but also in a fundamental inability to detect negative correlations (anticorrelations). Here, we propose to exploit the possibility of heterodyne mixing of the magnetic signal with static charge scattering to reconstruct the first-order (linear) magnetic correlation function. We show that the first-order magnetic scattering signal reconstructed from heterodyne scattering now directly represents the underlying magnetization texture. Moreover, we suggest a practical implementation based on an absorption mask rigidly connected to the sample, which not only produces a static charge scattering signal but also eliminates the problem of drift-induced artificial decay of the correlation functions. Our method thereby significantly broadens the range of scientific questions accessible by magnetic x-ray photon correlation spectroscopy. DOI:


The main purpose of this study is to know the CSR compliance obeyed by public sector enterprises in India. The
data have been gathered from annual reports of the chosen five Maharatna Companies of India. The data of
average profit prescribed CSR, and amount spent on CSR of company-wise have been tabulated and analyzed using
descriptive statistics and ANOVA. The study has been found that GAIL has maintained consistency in the amount
spent for CSR, while the other selected Maharatna companies showing high variance during the period of study.
Amongst these five, PGC has shown a tremendous increasing trend while the rest are showing decline or
fluctuation in the amount spent on social and environmental wellbeing. This study also found that excess amount
over and above mandatory requirement has been spent by SAIL, GAIL, and NTPC while BHEL and PGC show deficit
in the amount spent which shows that still, these two companies haven't spent full amount as per Companies Act
for CSR.


prehistory and noted many of the problems that still confront us (Shimada 1990). I would like to extend his comments by focusing on the state of research on Inca culture, using two recent books as examples of the progress we are making in understanding this contact-period culture. Research on Inca culture has been grounded in the perspectives of several disciplines, most notably archaeology, ethnohistory, and the history of art and architecture. Such interdisciplinary examination is essential to the study of an expansionist culture that left abundant material remains, but no written record, and whose expansion was cut short by an encounter with a European culture that successfully enforced its own imperial agenda. The close ties between archaeology and ethnohistory are perhaps most graphically noted by the observation that the first archaeological reports that we have for several important Inca sites were written early in the 17th century by the Jesuit, Bernabe Cobo, and are incorporated in an account that constitutes one of our most important ethnohistorical sources on the Incas (see Rowe, in Cobo 1990: viii). Ethnohistorical documents--contact-period histories, early eyewitness accounts, and Colonial legal documentshave been fundamental to archaeologists' attempts to put flesh on old bones. Historians with the requisite paleographic skills and access to archival materials have transcribed and evaluated a number of important documents; among them are Maria Rostworowski (1962, 1977, 1988), Waldemar Espinoza Soriano (1974, 1987; Didz de San Miguel 1964), Horacio Villanueva Urteaga (1970), and Maria del Carmen Martin Rubio (Betanzos 1987). The work of these and other historians has made it


NOvA is a long-baseline neutrino oscillation experiment, which consists of two finely-segmented liquid-scintillator detectors operating 14 mrad off-axis from the NuMI muon neutrino beam. With an 810 km baseline, the combined measurements of muon neutrino disappearance and electron neutrino appearance allow the determination of neutrino oscillation unknowns, namely the mass hierarchy, the octant of the largest neutrino mixing angle, and the CP violating phase. In this dissertation I present the joint analysis of νμ → νμ and νμ → νe oscillation data with an exposure of 8.85× 1020 protons on target on the 14 kton detector. It includes the estimation of neutrino energy distributions in the far detector using near detector data constraints, details of the implementation of the simultaneous fit of νμ and νe samples, and the effect of systematic uncertainties on the measurement of oscillation parameters. I also discuss NOvA's projected sensitivity to determine the mass hierarchy and discover CP violation in future analyses with increased exposure and the addition of antineutrino datasets. With 66 electron neutrino and 126 muon neutrino candidates, the best fit to the data corresponds to the normal mass hierarchy, ∆m32 =2.44×10−3eV 2/c4, sin θ23 = 0.56, and δCP = 1.21π, with the allowed regions ∆m32 ∈ [2.37, 2.52]×10−3eV 2/c4, sin θ23 ∈ [0.43, 0.51]∪ [0.52, 0.60] and δCP ∈ [0, 0.12π] ∪ [0.91π, 2π] at the 68.3% C.L. Our data disfavor maximal mixing by 0.8σ, δCP = π/2 in the inverted hierarchy at higher than 3σ, and the entire inverted mass hierarchy at the 95% confidence level. By increasing the size of the samples and adding anti-neutrino data, NOvA can potentially resolve the neutrino mass hierarchy at 4σ C.L. or higher for some combinations of oscillation parameters. Improvements to the sensitivity to the determination of the mass hierarchy and CP violation in the neutrino sector can be achieved through gains in the NuMI beam intensity, the inclusion of external data, and refinements in the analysis methodology.


The present essay shows the trajectory, innovative initiatives, publications and research activity of the research group: "Andalucia-America: Patrimonio y relaciones artisticas", founded in 2004 and leaded by Rafael Lopez Guzman.


Given that most research in online discussion addresses asynchronous discussions and that middle school students receive little opportunity to engage in sustained, substantive dialogues, there is a need to develop and pilot ways to instructional support students in sustained, online synchronous discussions about public policy issues such as why nations go to war. This article presents: a blended learning instructional model for an online synchronous discussion that was developed and piloted; instructional and logistical issues raised with the model; suggestions on conducting interschool online discussions to promote students' online voice; and, samples of students' thinking about what justifies war.


From the Publisher:
If you run a small business, you've already met the accounting monster. With QuickBooks and this all-in-one reference guide, you'll soon have him eating out of your hand. Eight self-contained minibooks make it easy to find just what you need, from accounting plans and principles to capital budgeting, protecting your financial records, creating a business plan, and more.


The leading cause of mortality for patients with end-stage kidney disease (ESKD) is cardiovascular disease (CVD). This is due, in part, to vascular calcification (VC) where calcium becomes deposited within arterial walls causing narrowing of the arteries and altering their flexibility. Matrix Gla protein (MGP), a vitamin k-dependent protein, is a key local inhibitor of VC and becomes up-regulated adjacent to sites of calcification. There is a very high prevalence of vitamin K deficiency in patients across the chronic kidney disease (CKD) spectrum and vitamin K has been shown to prevent VC in experimental models. To date, no trial has examined whether vitamin K supplementation prevents the progression of coronary artery calcification in patients with ESKD, a group in which high risk has been established. The aim of the iPACK-HD pilot study is to determine whether a trial to determine whether vitamin K has a favourable effect on coronary artery calcium (CAC) scores in patients with ESKD is feasible.

 The iPACK-HD pilot trial is a phase 2 multi-centre, double-blind, randomized, placebo-controlled clinical trial conducted in three sites (Kingston, Ottawa and London) in Ontario, Canada. Adult patients with ESKD on chronic dialysis with a baseline CAC score of ≥30 Agatston units (AUs) are randomized to receive 10 mg of vitamin K1 or matching placebo administered post-hemodialysis 3x/week for a total of 12 months. Exclusions include medical conditions that require anticoagulation and a history of either coronary artery bypass, grafting or stenting. Randomization is stratified based on diabetes and study centre. Baseline CAC scores are determined by computed tomography (CT) and demographic and laboratory data at study entry are obtained by participant interview and medical chart review.

 A total of 85 participants are randomized into this trial. Baseline characteristics of trial participants are reported as mean ± SD, median [IQR], or %. The mean age is 63 ± 13 years. There are a higher proportion of males (57%) than females and whites (85%) compared to all other ethnicities. Forty-four percent of participants have diabetes and 77% have hypertension. Dialysis vintage is 0.9 [0.4,2.7] years. Most participants take calcium-based phosphate binders (89%) and over half of participants take an HMG-CoA reductase inhibitor (53%) or vitamin D (61%). Clinical laboratory values are presented in Table 1. Total median CAC and volume calcium scores are 587 [252,1416] AUs and 482 [206,1170] mm3, respectively. Sixty-five (76%) participants had a study exit CT scan performed upon completion of the study. Of 156 doses, a median of 150 [123,155] were received and 2 [1,6] were missed.

 Participants in the iPACK-HD study have a high burden of calcification but are similar in baseline characteristics to the Canadian hemodialysis population. Loss to trial completion is 24%, but the most frequent reason is kidney transplantation. Adherence to study drug is very high with few reported side effects.


Together with our fellow-students of the Courses in French, Geography and History, we assembled on the evening of the 30th July at the University Lecture Rooms, Palace Green, Durham, and were welcomed on behalf of the University by the Dean of Durham and Canon Cruiokshanks, who promised lis that everything should be done by the authorities to make our visit to their historic city a pleasant one, a promise which it is needless to say was amply fulfilled.


To assess the efficacy of autologous conditioned serum (ACS) for the treatment of patients with knee osteoarthritis after failure of medical treatments and platelet rich plasma (PRP) injections.


In 1962 Anna Freud published her pioneering paper on the Diagnostic Profile, proposing a framework for organizing relevant clinical material and observations for the assessment of a child's inner world. Since that time, the Profile has been applied, with modifications, to work with babies, adolescents, adults, blind children, and others. This paper strives to demonstrate the Profile's applicability to a group often neglected in the psychoanalytic literature, namely the older population, a vibrant group frequently seeking psychotherapy and even psychoanalysis. A case study of a woman in her 70s is used to illustrate the advantages for clinicians of the Profile for a clearer understanding, both diagnostically and intrapsychically, of the older adult.


Blood leukocytes of Lepidochelys kempi were examined by bright-field microscopy and cytochemistry for the determination of glycogen, lipids, and several hydrolytic and oxidative enzymes. Mature large and small eosinophils and small lymphocytes were the principle leukocytes encountered; basophils were rarely seen, and neutrophils and monocytes were not demonstrated. The large eosinophils contained two types of granules and demonstrated periodic acid – Schiff (PAS) reactivity and some sudanophilia. The large eosinophils also possessed alkaline phosphatase, myeloperoxidase, adenosine triphosphatase, and some nonspecific esterase activity. The small eosinophils demonstrated acid phosphatase. No reactivity for β-glucuronidase, aryl-sulfatase, or for the oxidative enzymes, succinate, lactate, and glucose-6-phosphate dehydrogenases, or cytochrome oxidase, occurred in the large or small eosinophils. Small lymphocytes contained a few PAS-positive granules or intracellular particles; some nonspecific esterase activ...


In the teaching of"principles",we not only need to expound the scientific quality and truthfulness of principles,but also fully explore the humanitarian spirit connoted in Marxist theory.It is a basic requirement by the Marxist theory itself as well as that by the teaching of this course,ideological and political education of the students,and the facilitation of the popularization of Marxism to strengthen the education of humanitarian spirit in the fundamental principles."Cooperative mode"of theme teaching is a valid form of humanitarian spirit education.


The purine metabolism of a number of bacterial species has been studied in recent years. The present study is a contribution to an understanding of the purine metabolism of Staphylococcus aureus and consists of an examination of the utilization of various purines by paired strains of this organism. These nutritional studies have revealed that S. aureus can convert guanine to adenine but that adenine cannot be converted to guanine, probably due to an inability to synthesize hypoxanthine from adenine. Another part of this study comprised an elucidation of the mechanism of action of 2, 6-diaminopurine. The metabolism of this compound has been studied extensively by a number of investigators. Diaminopurine has been observed to display a number of diverse and apparently unrelated functions. For example, it is both an antagonist of adenine and also a good source of purines for Lactobacillus casei (Balis et al., 1952); it is an antagonist of folic acid in Streptococcus faecalis (Hitchings et al., 1954); it is methylated to 2-methylamino-6-aminopurine by Escherichia coli (Remy and Smith, 1957); it is a competitive antagonist of xanthine oxidase (Wyngaarden,


A cataract is the most common cause of vision impairment and blindness worldwide. The Rapid Assessment of Avoidable Blindness survey held in 2014 - 2016 showed that the prevalence of blindness in West Nusa Tenggara was the second highest in Indonesia. This prevalence was expected to be higher in rural areas due to cultural barriers, patient education, and accessibility to eye-care facilities. This study aims to evaluate visual acuity improvement after cataract surgery and observe the sight restoration rate. The participants of this study were cataract patients who underwent surgery at Sumbawa Hospital West Nusa Tenggara between 27 - 30 August 2018 in a social service program held by the Sanglah General Hospital team. Surgery was not performed on patients who did not desire surgery, in cases where the surgery would not improve visual function, and on patients who were known to be medically unfit for safe surgical intervention. Demographic data and visual acuity at admission and postoperative day one were recorded and analyzed. The output of this program was qualitatively measured by analyzing the SRR. A total of 86 patients were included in this study. Visual acuity postoperative day one showed improvement, and the blindness percentage dropped to 51.16%. The sight restoration rate observed in this study was 58.14%. Although the benefits of cost-effective cataract surgery are straightforward, challenges to executing the procedure remain high, such as unaffordability surgery costs and accessibility to eye-care facilities and infrastructures. Equitable growth in other fields can automatically increase healthcare services in rural areas and encourage healthcare workers to spread evenly.


Topsoil samples taken from the Biluochun tea plantations in Xishan of Tai Lake were analyzed for contents and distribution of heavy metals(Cd,Hg,As,Pb,Cr and Cu) in the soil.Effects of geomorphological characters,such as slope and land use,on the distribution of soil heavy metals were also discussed.Soil quality was evaluated by the standard(NY 5199-2002) for soil environmental quality of organic tea plantations and the Criteria of Grade II of the National Standards for Soil Environmental Quality(GB 15618-1995).It was found that all the heavy metals in the soil,except Hg,were in compliance with the standards in concentration,and that their integrated pollution index was 0.78,suggesting that the soil is still clean and of the Alert Grade in pollution,and that its major pollutant is Hg.