The paper at hand investigates forms and interpretations of author personae in autobiographical videogames. While, previously, autobiographical modes of expression have only been discussed in a few game-based artworks (Poremba 2007), the availability of free, easy-to-use tools like Twine and Ren'Py gradually affords autobiographical writing as a cultural technique outside of deliberately artistic endeavors. Therefore, the paper considers the creation and distribution of autobiographical games as a playful form of identity politics. For that purpose, a comparative content analysis (cf. e.g. Rossler 2012) of selected autobiographical games will be conducted, taking into account rhetorical and audiovisual elements but focusing on procedural design strategies and "bias" (Bogost 2008, 128). The corpus includes explicitly autobiographical sketches like Gravitation (2008) and Dys4ia (2012), but also cases in which the autobiographical characteristics are only implied like The Average Everyday Adventures of Samantha Browne (2016) as well as less polished, sometimes unfinished vignettes. This approach will be selectively complemented by a rhetorical analysis of paratextual elements such as developer statements and user comments. Play and games are increasingly recognized as modes of conceptualizing and expressing individual identity (Frissen et al. 2015, 35–36) that are particularly compatible with postmodern sensibilities. Consequently, the focus of the analysis will lie on how the implementation of the author personae as playable characters enable the developers to curate their identity online, both in terms of Moreno's psychodrama (Moreno 1987) and Foucault's technologies of the self (Aycock 1995).


The research on inaccessible pore volume is completed on the basis of laboratory experiments. The experiment prepared 4 different kinds of polymers, whose molecular weight are 8 million, 12 million, 16 million and 20 million whose molecular coil size are measured by light blockage counter. Through kerosene mass method we can get pore cumulative distribution of field cores and finally plot the relation between the inaccessible pore volume and molecular coil size of polymer. The size of small pore where primary water was taken as the minimum number polymer coils can be passed. Then the polymer molecular weight with better compatibility with rock pores is optimized. The study shows with the increase of polymer relative molecular mass, pore volume increased linearly. The conclusion can better guide the selection of the polymers in practical production.


This study is to observe the effects of social skills
training on the pupils self-concepts. Thirty pupils from
four different schools in Ipoh namely Sekolah Menengah
Megat Khas, Sekolah Menengah Hulu Kinta, Sekolah Menengah
Kampung Pasir Puteh and Sekolah Menengah Gunung Rapat, were
taken as subjects of the study. The module used was the
communicational skills module. The activities in the module involving the variables of family self, personal-emotional self, physical self, social-behavioral self and
satisfaction-moral ethical self. The Martinek-Zaichkowsky
Self -Concept Scale for Children was used for the pre and
the post-test. T-test was used for the data analysis. The
result shows that there are some improvement in the selfconcept of the experimental groups. There is no
significant difference between the boys and the girls
except for the physical self where the boys show a better
performance.


AGREEMENTS WITH CLAIMANTS by specialty chemical maker Chemtura and titanium dioxide producer Tronox have brought each company close to an exit from bankruptcy reorganization. In Chemtura's case, the firm has agreed to pay $50 million to settle 347 claims brought by individuals who allege that the diacetyl butter flavoring ingredient the firm supplied is responsible for causing a lung disease. For its part, Tronox has reached an agreement with key creditors and filed an amended reorganization plan. Both firms have Sept. 16 court approval hearings set. According to documents filed with the Securities & Exchange Commission, Chemtura reached agreement with Humphrey, Farrington & McClain, a law firm that represents more than 90% of individual diacetyl claims, mostly on behalf of microwave popcorn factory workers. Still pending are another 19 individual claims and seven others brought by firms that distributed butter flavoring. The specialty chemical company also reached a separate agreement with insurers that ...


In this document we describe the Darlin proof carrying data scheme for the distributed computation of block and epoch proofs in a Latus sidechain of Zendoo [GKO20]. Recursion as well as base proofs rest on Marlin [CHM20] using the Pasta curves [HBG] and the 'dlog' polynomial commitment scheme from [BCC16, BBB18]. We apply the amortization technique from Halo [BGH19] to the non-succinct parts of the verifier, and we adapt their strategy for bivariate circuit encoding polynomials to aggregate Marlin's inner sumchecks across the nodes of the proof carrying data scheme. Regarding performance, the advantage of Darlin over a scheme without inner sumcheck aggregation is about 30% in a tree-like scenario as ours, and beyond when applied to linear recursion.


Affirmative action policies often take two forms: quotas, where a certain number of individuals from underrepresented minority groups are to be admitted; and priority subsidies, where these individuals are given higher admissions scores relative to some baseline. Should a policymaker concerned with both match quality and diversity pursue quotas or priority subsidies? We show that the two policies are equivalent under perfect information. However, this equivalence breaks under imperfect information. The trade-off between priorities and quotas is governed by the risk aversion of the policymaker over the number of minorities to admit. When the policymaker is close to risk-neutral, priority subsidies are optimal as minority students are admitted in greater numbers in the states of the world where match quality is highest. Conversely, with high risk aversion, quotas are optimal as they smooth the number of admitted minorities. Our results therefore echo the trade-offs between price and quantity regulation in product markets highlighted by Weitzman (1974) in a market without an explicit price mechanism. Significantly for the practice of affirmative action, the equivalence of priorities and subsidies under perfect information constitutes a legal puzzle given that race-based quota policies are illegal in the US, while there is scope for priority subsidies that depend on race.


The thermo-oxidative aging of a polyether urethane lightguide primary coating has been studied in films and dual-coated fibers, In films, oxygen absorption is correlated with changes in modulus, yellowness, glass transition temperature, and sample weight. Thermal aging of fibers shows similar trends with regards to coating weight loss and discoloration as those observed with films. In addition, the force to mechanically strip the fiber follows the same patterns of change as the modulus of aged films. For both films and fibers, the time for onset of property changes varies inversely with temperature and can be delayed by the incorporation of an antioxidant.


Abstract The protests of 2020 cast a national spotlight once again on police brutality and ongoing racial injustice in America. Within this context, many activists and even mainstream commentators have given more attention to a critical analysis of how American history has been taught, especially regarding race relations. The publication of the 1619 Project has touched off a wave of controversy regarding some of its historical claims and its larger interpretation of American history. In this paper, we analyze some of the discourses that have emerged from the post-publication controversy over the 1619 Project and then discuss applications of our inquiry for the preservice teacher classroom. The paper will provide an overview of the background of the topic, important theoretical frameworks, methods, and sources.


The technique of pulse detection in nuclear signal is explored in the paper.The low pass differential(LPD) filter method is applied to enhance and extract the pulse waveforms,and the empirical mode decomposition(EMD) method is utilized to suppress the noise.The experiments show that the satisfying result of noise reduction can be acquired by EMD method,the enhancement and pile-up separation of pulse waveforms can be implemented by LPD filter.The computational complexity of LPD filter is lower,and it is able to meet the real-time processing requirement.Therefore,the LPD filter is an effective pulse detection method for nuclear signal.


Cerium-doped gadolinium pyrosilicate single crystals (Ce:GPS) with various Ce concentrations of 2.5-30 mol% with respect to the total rare-earth sites were prepared by the floating zone method. Their scintillation perfor- mances were investigated under irradiation of gamma rays of . The Ce concentration dependence of scintillation charac- teristics and high-performance scintillation characteristics were obtained: 3-6 times greater light output than that of BGO single crystals, rapid decay, and good energy resolutions of 5.1-8.4%. Furthermore, X-ray diffraction patterns of Ce:GPS revealed Ce concentration dependence of the crystal structure of Ce:GPS. Index Terms—Crystal growth, gadolinium compounds, , neutron detectors, radiation detectors, scintilla- tors.


Abstract. In order to improve the quality of pelleting and detect the influence of compression conditions during pelleting, a set of single pellet compression device was built in this research. The diameter of die hole was 10mm and preset load was 64MPa. Three kinds of alfalfa grinds samples (leaf content:0, 50%, 100%) were compressed to pellets at the temperature of 20℃, 80℃ and 140℃. The effect of compression times (1, 2, 3 times) was also detected using the device. The density and specific energy were calculated by the compression data. The results showed that the single pellet compression device was used to do the compression testing successfully. Temperature, leaf content, compression times significantly affected the density of alfalfa pellets and energy consuming. The pellet density increased with the increasing of temperature, leaf content and compression times. The higher density of pellet can be obtained using less energy when the grinds samples were preheated to a high temperature. It was also obviously increased when compressed two or three times at a low temperature. However, the compression times were not insignificant when the grinds were preheated to 140℃i¼Œbecause the pellets had reach the highest density (true density of samples) at the first compressed.


A central goal of The Academy of Breastfeeding Medicine is the development of clinical protocols for managing common medical problems that may impact breastfeeding success. These protocols serve only as guidelines for the care of breast-feeding mothers and infants and do not delineate an exclusive course of treatment or serve as standards of medical care. Variations in treatment may be appropriate according to the needs of an individual patient. Purpose 1. To provide guidance in distinguishing those causes of jaundice in the newborn that are directly related to breastfeeding from those that are not directly related to breastfeeding. 2. To guide monitoring of jaundice and bilirubin concentrations and management of these conditions in order to preserve breastfeeding while protecting the infant from potential risks of toxicity from hyperbilirubinemia. 3. To provide a protocol for hospital and office procedures for optimal management of jaundice and hyperbilir-ubinemia in the breastfed newborn and young infant. The reader is referred to several comprehensive reviews of bilirubin metabolism and jaundice in the newborn that are listed in the references for a more complete discussion of the biology and pathobiology of jaundice in the newborn. 1–6 Although management of breastfeeding and jaundice varies among the nations, these principles and recommendations apply universally. Hyperbilirubinemia of the newborn All newborns have some elevation in unconjugated (indirect-reacting) bilirubin relative to normal adult values (1.5 mg=dL; 26 mmol=L). Higher values in unconjugated bilirubin result from a combination of increased production of bilirubin from heme degradation, decreased hepatic uptake and conjugation of bilirubin, and increased intestinal re-absorption of bilirubin. 7 In the first week of life, a significant proportion of all newborns will have total serum bilirubin concentrations greater than 5.0 mg=dL (86 mmol=L); these infants are likely to appear jaundiced. Data indicate that approximately 40% of healthy newborns have a total bilirubin of 5 mg=dL at 24 hours and 7 mg=dL (120 mmol=L) by 36 hours of age 8 (Fig. 1). This normal elevation in unconjugated bilirubin is termed ''physiologic hyperbilirubinemia of the newborn.'' Breastmilk jaundice Breastfed infants regularly and with high frequency (two-thirds or more) have unconjugated hyperbilirubinemia that extends into the second and third weeks of life and often up to 8–12 weeks of life. 9,10 In contrast to formula-fed infants, approximately half of all breastfed infants may appear slightly to moderately jaundiced in the second and later weeks of life. This prolongation of physiologic jaundice due to …


A curing agent for epoxy resin which comprises at least one selected from 1-aminopyrrolidine and its salt, as an effective component.


Publishers details for: Law, Modernity, Postmodernity: Legal Change in the Contracting State, by Edgeworth, Brendan, Aldershot, Ashgate, 2003, ISBN 1840140097, viii and 304 pp. Includes footnotes.


The present invention, embryonic-like stem cells derived from postpartum placenta provides compositions and methods for use with conventional cord blood composition or other stem or progenitor cells. Embryonic-like stem cells can be utilized alone or as a mixture with other stem cell populations. According to the present invention, embryonic-like stem cells, umbilical cord blood, fetal and neonatal hematopoietic stem and progenitor cells, including progenitor cells from human stem cells and bone marrow are not limited to, it can be mixed with other stem cell populations. There are numerous applications and applications in a mixed population of embryonic-like stem cells and embryonic-like stem cells and stem cells, for example, but not limited to, transplantation and disease treatment and prevention for therapeutic use, diagnostic applications, research applications and so on.


The present invention is a method of cooling the hot-rolled steel sheet after the finish rolling, which involves the transport velocity change, comprising the steps of: on the basis of the steel sheet temperature before carrying out the finish rolling and the conditions of the finish rolling, setting the conveying speed change schedule, the first in the cooling section, the second cooling in the step of performing a first cooling for cooling the hot-rolled steel sheet in the film boiling state, and a second cooling zone, cooling the hot rolled steel sheet in water density over 2㎡ / min / ㎡ comprising the step of performing the winding step, the hot-rolled steel sheet, 0.8≤ (T2a'-T2a) so as to satisfy the /ΔTx≤1.2, provides a method of cooling hot rolled steel sheet for controlling the cooling condition in the first cooling do.


Assessing soil quality (SQ) of cropland is fundamental for food security and sustainable land management. However, there is limited information regarding SQ assessment on a national scale, which is vital to answer important SQ‐related questions in quantitative terms on that scale. Here, the SQ of cropland in China was assessed by constructing a minimum data set (MDS) from 23 soil physicochemical properties based on principal component analysis. The interaction roles and relative contributions of climate and topography on SQ was evaluated by a structural equation model. The MDS comprised eight indicators: proportion of silt, bulk density, total phosphorus, total potassium, available nitrogen, exchangeable calcium, chlorite, and vermiculite. The soil quality index (SQI) varied from 0.245 to 0.705 and showed a clear pattern of decreasing quality from the north to the south of the country. Of the total cropland area in China, the largest share (27.91%) was of soils of high quality, followed by those of moderate quality (24.63%), low quality (20.37%), very high quality (14.18%), and very low quality (12.91%). The north and the south differed significantly in terms of total potassium, exchangeable calcium, chlorite, and vermiculite, which are the four most important indicators of SQ. Climate and elevation explained about 2.2%–30.1% of the variation in SQ on the national and regional scales. These findings suggest that croplands in southern China will benefit from potassium and calcium fertilizers, which will contribute to enhance food security and promote sustainable land management in China.


Abstract— We report results of our investigation of the relationship between values of Is/FeO (relative concentration of nanophase Fe0 divided by total FeO content), glass abundance, total Fe content, and degree of digestion of <20 μm clasts for 22 individual agglutinates (250–1000 μm) from the mature Apollo 16 soil 61181 (Is/FeO = 82 units in the <250 μm fraction). Agglutinates are important products of space weathering on the Moon, and they influence spectral observations at visible and near-IR wavelengths. Values of Is/FeO for individual agglutinates (250–1000 μm) within this single soil span a range from 3 to 262 units which is larger than the range observed for all Apollo 16 bulk soils (∼0 to 110 units). No correlation was observed between Is/FeO and glass abundance and FeO concentrations for either agglutinitic glass or whole agglutinate particles under investigation. Our results suggest that the variation in Is/FeO for agglutinates from a single soil may be in part a consequence of natural mixing processes on the Moon that produce highly-variable environments (with respect to surface exposure) for agglutinate formation and in part to variable kinetics of reactions in an agglutinate melt, which are influenced by a variety of factors including melt composition, temperature, impactor velocity, and quench rate. We cannot exclude but do not see evidence for other processes including addition of exotic agglutinates, micrometeoritic bombardment into compositionally-diverse microtargets, recycling of agglutinates, preferential melting of very fine soil particles, and production of nanophase Fe0 in amorphous rims of very fine irradiated lunar grains contributing to the observed variation of Is/FeO.


Louis Dumont, who died in 1998, was one of the most important figures in post-war French anthropology. He is well-known for his early work on India, which culminated in Homo Hierarchicus (1966; in English 1972, 1980), an anthropological account of the caste system. He later extended this work into a comparison of the values of Indian and western society in works like Essays on Individualism (1986) and German ideology: From France to Germany and Back (1994). He is also known for pioneering work on kinship in south India and more generally (for example Affinity as a Value, 1983). The current volume represents the fruits of this side of his activities and originated in as a series of lectures providing an account of the British and French schools for students. Robert Parkin is a Departmental Lecturer in Social Anthropology at the University of Oxford. He has a longstanding interest in the anthropology of kinship, represented by Kinship: an Introduction to Basic Concepts (1997) and Kinship and Family: n Anthropological Reader (2004, edited with Linda Stone). He has also published a full-length study of Dumont in the same Berghahn series (Louis Dumont and hierarchical opposition, 2003).


Book synopsis: France's opposition to the Iraq war in 2003 was greeted with surprise and outrage by Anglo-American politicians. But as David Styan argues in his penetrating new book, Chirac's stance was consistent with a decades-long reorientation of French foreign policy. Styan dissects the processes by which a country notorious for its suppression of Algerian independence came to cast itself as the anti-imperialist champion of the Arab world. Styan charts France's divergence from the other Western powers in its relations with Iraq, uncovering the interplay between historical relationships, military industrial interests and geopolitics, which gave rise to it. Negotiating these currents are a range of vivid personalities from De Gaulle to Mitterrand.


In this extended abstract, we generalize active learning to tasks where a human has to choose which action a to take for a target after observing its covariates ˜ x and predicted outcomes p (˜ y | ˜ x, a ) . An example case is personalized medicine and the decision of which treatment to give to a pa-tient. We show that standard active learning, which is not aware of the final task, would be very inefficient, and we introduce a new problem of decision-making-aware active learning. We for-mulate the problem as finding the query with the highest information gain for the specific decision-making task, assuming a rational decision-maker. The problem can be solved particularly efficiently assuming an expert able to answer queries about counterfactuals. We demonstrate the effective-ness of the proposed method in a binary outcome decision-making task using simulated data, and in a continuous-valued outcome task on the medical dataset IHDP with synthetic treatment outcomes. The outcomes are predicted using Gaussian pro-cesses. ,


Abstract—Road transportation system is the most important method of transporting the goods. Considering the most suitable geographical situation of Iran to transport the goods between Europe and Asia and placement of this country in direction of international corridors (eastwest) , (north-south) and Asian land transport to infrastructure development "A.L.T.I.D" and Transport corridor Europe Caucasus Asia "T.R.A.C.E.C.A", noticing the security of road transportation system in this country is so important. In this paper the main factors of accidents on the roads of Iran are categorized regarding the rate of accidents occurred. Then apart from studying the main reasons of accidents of every category, the main factors of these events are studied and its strategies in Iran are introduced.


Many well-known complications are associated with the use of continuous epidural catheters, including epidural hematomas and abscesses, inadvertent catheter migration into veins or the subarachnoid space, and mechanical problems related to kinking or shearing of catheters. We wish to report an unusual complication that is not mentioned in major texts dealing with regional anesthesia (1-4). This occurred during our use of a Portex epidural catheter. After searching the literature we were able to find only two letters to the editor relating to this type of problem (5-6). Presented here is a report of the incident together with the results of an in vitro laboratory study performed in an attempt to determine why this problem might have occurred.


A 4-methylsterol was isolated from the unsaponifiables of rice-bran oil by preparative thin-layer chromatography (TLC), and identified as cycloeucalenol [4α, 14α-dimethyl-9, 19-cyclopropane-24 (28) -methylene cholestan-3β-ol] by TLC, IR, NMR and combined GC-MS, the occurrence of which in rice-bran oil had not yet been reported.The cycloeucalenol and its acetate showed mp 141142°C and 110111°C, respectively. Cycloeucalanol derived from the cycloeucalenol by hydrogenation and its acetate showed mp 147-148°C and 112113°C, respectively.


Objective:To discuss the value of CT diagnosis of the ovarian carcinomas.Methods:The CT findings of 20 cases of ovarian carcinomas confirmed by surgery and pathology were analysed retrospectively.Results:①CT has a detection rate of 96 7% for ovarian tumors and an accuracy rate of 90% in qualitative diagnosis.②ovarian epithelioma present irregular masses in pelvic in CT.The masses can be divided into solid,cystic and mixed types.③CT has a sensitivity of 100% for a right subdiaphragmatic metastasis focus of 5mm or more.It has relatively a sensitivity of 62 5% and 85% for metastasis focus of 5mm or more in rectouterine pouch and omentum majus while a sensitivity of 66 7% for metastasis lymph node over 1cm.Conclusion:CT is valuable for the qualitative diagnosis of ovarian epithelioma and the detecting metastasis focus in abdomen.


Objective To study the role of thyroperoxidase(TPO) in the different diagnosis between malignant and benign thyroid papillary hyperplasia.Methods The expression of TPO protien in 50 cases of papillary thyroid carcinomas and 50 cases of thyroid nodular goiter with papillary hyperplasia were dectected by inmmunohistochemistrical EnVision Method. Results Of the 50 cases thyroid papillary carcinomas,48 were negative and 2 were positive for TPO;while all of the 50 cases of nodular thyroid goiters with papillary hyperplasia were positive for TPO.The values of TPO in the different diagnosis between malignant and benign thyroid papillary hyperplasia were assessed below: sensitivity was 96%,specificity was 100%,accuracy was 98%,+PV was 100%,and-PV was 96.15%. Conclusion TPO protein is a useful marker in the differential diagnosis between malignant and benign thyroid papillary hyperplasia.


Equipped with the ultimate query answering system, computers would finally be in a position to address all our information needs in a natural way. In this paper, we describe how Language and Computing nv (L&C), a developer of ontology-based natural language understanding systems for the healthcare domain, is working towards the ultimate Question Answering (QA) System for healthcare workers. L&C's company strategy in this area is to design in a step-by-step fashion the essential components of such a system, each component being designed to solve some one part of the total problem and at the same time reflect well-defined needs on the prat of our customers. We compare our strategy with the research roadmap proposed by the Question Answering Committee of the National Institute of Standards and Technology (NIST), paying special attention to the role of ontology.


In this work we study the stability of a stationary solution to the thin-film equation with linear mobility and partial wetting boundary conditions. The method used is strongly based on the gradient-flow structure of the problem. We obtain natural relaxation rates of perturbations to the stationary solution by showing that the energy is in fact convex in a neighborhood around the stationary solution.


The application of T1 in the rotating frame (T1ρ) to functional MRI in humans was studied at 3 T. Increases in neural activity increased parenchymal T1ρ. Modeling suggested that cerebral blood volume mediated this increase. A pulse sequence named spin‐locked echo planar imaging (SLEPI) that produces both T1ρ and T2* contrast was developed and used in a visual functional MRI (fMRI)experiment. Spin‐locked contrast significantly augments the T2* blood oxygen level‐dependent (BOLD) contrast in this sequence. The total functional contrast generated by the SLEPI sequence (1.31%) was 54% larger than the contrast (0.85%) obtained from a conventional gradient‐echo EPI sequence using echo times of 30 ms. Analysis of image SNR revealed that the spin‐locked preparation period of the sequence produced negligible signal loss from static dephasing effects. The SLEPI sequence appears to be an attractive alternative to conventional BOLD fMRI, particularly when long echo times are undesirable, such as when studying prefrontal cortex or ventral regions, where static susceptibility gradients often degrade T2*‐weighted images. Magn Reson Med, 2005. © 2005 Wiley‐Liss, Inc.


In a fixed-bed flow reactor and under an industrial Ni/Al2O3 catalyst,the reaction conditions of CO2 and CH4 which simulated coke oven gas without H2 were studied.At reaction temperatures of 700~1 000 ℃,system pressures of 0.1~0.6 MPa and CO2/CH4 ratio 1.0~2.5 ranges,CH4 conversion increases as temperature and the CO2/CH4 ratio increase,and decreases as pressure goes up.The optimal space velocity is 2 700 h-1,and CO2/CH4 ratio is 2.The CH4 conversion can attain 100 %.The catalyst has some carbon deposition during reaction,but it is easy to regeneration by air combustion.


The Advance Manufacturing Technology (AMT) Project supports multiple activities within the Administration's National Manufacturing Initiative. A key component of the Initiative is the Advanced Manufacturing National Program Office (AMNPO), which includes participation from all federal agencies involved in U.S. manufacturing. In support of the AMNPO the AMT Project supports building and Growing the National Network for Manufacturing Innovation through a public-private partnership designed to help the industrial community accelerate manufacturing innovation. Integration with other projects/programs and partnerships: STMD (Space Technology Mission Directorate), HEOMD, other Centers; Industry, Academia; OGA's (e.g., DOD, DOE, DOC, USDA, NASA, NSF); Office of Science and Technology Policy, NIST Advanced Manufacturing Program Office; Generate insight within NASA and cross-agency for technology development priorities and investments. Technology Infusion Plan: PC; Potential customer infusion (TDM, HEOMD, SMD, OGA, Industry); Leverage; Collaborate with other Agencies, Industry and Academia; NASA roadmap. Initiatives include: Advanced Near Net Shape Technology Integrally Stiffened Cylinder Process Development (launch vehicles, sounding rockets); Materials Genome; Low Cost Upper Stage-Class Propulsion; Additive Construction with Mobile Emplacement (ACME); National Center for Advanced Manufacturing.


In a perfectly transparent and competitive market, suppliers must provide a competitive pricing and service for their customers. The aim of this study is to provide an insight into how preservation technology and credit financing could be used both to reduce the deterioration rate as well as to provide flexible financing for retailers. The methodology is to optimize the cycle length, selling price, the amount of preservation technology and credit financing using inventory theory. The result derived is an optimal total profit per unit time for the system. Finally, using MATLAB 2017a, it is shown graphically that the profit function is concave. The sensitivity analysis is illustrated using Lingo 17. The study not only provides insights to business managers in making wise managerial decisions, it also enables them to weigh the pro and con of implementing preservation technology and credit financing.


A CERIF-CRIS consists of base entities with records describing components of the research and link entities describing relationships among records in the base entities. As an example, three base entities may contain records describing a person, a publication and a project while two link entities relate respectively the person to the publication in role author and the person to the project in role project leader. This powerful linking or inter-relating capability includes temporal as well as role aspects and inter-relates dynamically and flexibly all the components of R&D. The CERIF model can be extended to inter-relate appropriate information from legacy information systems in an organisation, such as those covering accounting, human resources, project management, assets, stock control, etc. A CERIF-CRIS can thus provide a flexible low-cost integration comparable with an ERP (Enterprise Resource Planning) System, particularly in an organisation with R&D as its primary business.


The reaction of substituted oxazoles with 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) or diethyl azodicarboxylate gave the corresponding 1,2,4-triazoline derivatives through formal [3+2] cycloaddition accompanying ring opening of oxazoles. The molecular structure of an adduct of 5-methoxy-4-methyl-2-(p-tolyl)oxazole with PTAD was determined by means of X-ray crystallography.


Thresholds of vision under low-light conditions have been studied for determining the human response to light stimuli in different contexts. Blackwell's work on thresholds of vision of the human visual system did not explore some variables whose analysis would help to characterize more deeply the visual system. This paper extends Blackwell's results exploring new dimensions of the human visual system response including chromaticity of the stimuli, mono/binocular vision, and dark adaptation. Tests have been performed on a sample of 45 observers, with a simplified laboratory setup with respect to Blackwell and without specific hardware/software, producing results in terms of visual adaptation, monocular, and binocular vision and aging effects.


The present note represents the inventary of the parasitic copepods found on marine fishes between 1940-1949 and which are kept in the "Instituto Paulista de Oceanografia" (Sao Paulo Oceanographic Institute). They all belong to the Suborders Cyclopoida, Caligoida and Lernaeopodoida and were partly received as donations and partly collected by the staff of the Institute, during its periodic trips to the coast of the State of Sao Paulo (Brazil); finally, a small fraction was obtained from parasitized fishes purchased on the markets of Santos an Sao Paulo. The author, thus, gathered 117 specimens, distributed by 8 families, 11 genera and 13 different species, one of which belongs to the genus Caligus and could not be specifically determined due to the lack of bibliography. The Copepods were obtained from 22 fishes, among which only 5 were abundantly infected and exhibited respectively 10, 14, 16, 18, and 37 parasites. None of the hosts showed any sign of evident organic weakness.


The article examines the ideas of environmentalism in the works and statements of His All Holiness Ecumenical Patriarch Bartholomew I. The ecological concept of the "Green Patriarch" reveals the relations between religion and the environment. The cause of the environmental crisis is recognized as a crisis of spirituality. It is argued in the concept that utilitarian logic and ethics are not enough to change human behavior towards the environment – ecological thinking requires another worldview that can be found in religion. In particular, from the point of view of Orthodox spirituality, the environment is a miracle of the Divine creation. Therefore, the world is a sacred place, a miracle, a place of beauty and communication with the Creator. Awareness of the beauty and harmony of the cosmos involves understanding the balance and measure. The way to achieve them is asceticism. The latter is realized through self-control, which is manifested in the balanced consumption and use of only the necessary resources and the abandonment of abusive consumption for the benefit of others. The universal principle of the philosophy and ethics of the environment is the instruction to preserve resources for future generations; this is repeatedly emphasized in the speeches and works of His Holiness Ecumenical Patriarch Bartholomew I.


We know that traveling by motor-vehicle is extraordinaly increasing year by year through the developments of automobile and arrangements of highway net-work. It must be established that various methods needed for the safety, efficiency and relief of highway traffic. One of them is in the planning and arranging of parking spaces. By the planning it is necessary to calculate the needed spaces by farseeing the every years increases in future.But about sight-seeing parking places, the frequency of happening of parking demands have seasonably, daily and timely considerable variations, and then maximum happening of them is concentrated near the some hours in a day. The author has analysed these parking characteristics, and presented a method of estimation in future of parking demands, and then shown the theory of distribution test to deal with the data for the basic planning, so calculated the required spaces by use of this theory, then given several numerical examples in this paper.


Background: Neurosurgery was first practiced in Victoria, BC in the 1950's. It has grown from 1 neurosurgeon to 6 neurosurgeons today. Methods: Research into the beginning of Neurosurgery in Victoria demonstrates that it started with one surgeon and has grown significantly over the past 60 plus years. Results: Although Neurosugery started in Victoria with humble beginnings it has now developed into a sophisticated unit with 6 neurosurgeons with various subspeciality interests including complex and minimally invasive spine, cerebrovascular and neuro-oncology. Conclusions: The Neurosurgery division in Victoria has grown over the years from a single surgeon to 6 surgeons practicing a wide scope of neurosurgical procedures.


As there are still some problems in previous study on safety information management and visual analysis of slope engineering such as inadequate description of dynamic properties of 3D model,and incomplete expression of safety information.This paper the proposed establishment method of 4D safety information model of slope during construction in hydropower station by introducing 4D technique and safety information model. Key techniques such as establishment of information carrier model,database storage and visualization of safety information,and construction-model /information dynamic mapping method are mainly researched,finally dynamic visualization management system of slope safety information during construction is developed with C#. NET and OpenGL. Taking the slope of a hydropower station for example,coupled visualization of the figure in different construction stages and structure safety condition is displayed,real-time update of safety information with construction progress is realized,and evolution law of slope safety during construction is revealed visually. These may meet engineers' demand for visual expression and real-time dynamic visual analysis of slope safety information during construction period.


Exploring how women's menstruation and childbirth are depicted in Scripture and considering the ways in which this depiction may be altered to be more positive and inclusive.


Nuclear characteristic parameters were calculated and subcriticality judgment graphs were drawn for revision of the Data Collection for the Nuclear Criticality Safety Handbook. The calculated nuclear characteristic parameters were the neutron multiplication factor in infinite media, migration area and diffusion constant for 11 kinds of typical fuels encountered in criticality safety evaluation of nuclear fuel cycle facilities. These fuels included ADU-H2O, UF6-HF and Pu(NO3)4-UO2(NO3)2 solution, of which data were not cited in the Data Collection. The calculation was made with the Japanese Evaluated Nuclear Data Library JENDL-3.2 and a sequence of criticality calculation codes, SRAC, POST and SIMCRI. The subcriticality judgment graphs that depict the region of the two variables (a) uranium enrichment, 239Pu/Pu ratio or plutonium enrichment and (b) H/(Pu+U) ratio where the neutron multiplication factor in infinite media k∞≤0.98 were drawn for the same kinds of fuels except UF6-HF. The limitations of the subcriticality judgment graphs were also discussed.


A hybrid monomer consisting of diphenylalanine with the self-assembling ability and tetraphenylethylene with aggregation-induced emission properties was synthesized and employed for reversible addition–fragmentation chain transfer polymerization.


It is well known that torsional oscillations during an earthquake may cause severe distress in a building structure. Most seismic building codes therefore include some provisions for the design of structures to resist the forces induced by torsional vibrations. Provisions of several codes on design against torsion are reviewed. The review includes the National Building Code of Canada (NBCC), 1995; the Uniform Building Code (UBC), 1997; the National Earthquake Hazard Reduction Program (NEHRP), 1997; New Zealand Standard (NZS), 1992; Mexico Code, 1993; and a set of provisions being considered for NBCC 2005. A mono-symmetric single-story building model is analyzed for its elastic response to ground motions represented by idealized spectral shapes, and for its inelastic response to a set of 16 recorded earthquake ground motions. The results of the analytical studies are used to examine the effectiveness of various design provisions.


Fei Xiaotong's thought emphasizes the importance of small towns,holding that small towns and township enterprises complement each other,and the small towns function as reservoirs of rural population and links of the integration of the urban and rural areas.His thought is significant and revelatory for the building of the new socialist countryside,that is,we ought to take the scientific outlook of development as the guidance,to propel the coordinated development between small towns and township enterprises,and to take the road to rural modernization with Chinese characteristics.


Good linear correlations exist both between the bond dissociation energy of an Si-H bond and the corresponding SiH stretching frequency and between the 29 Si hyperfine splitting of a silicon-centered radical and J( 29 Si-H) for the corresponding silane, when the successive substitution at the Si-H function takes place inside a family, i.e., (Me 3 Si) 3-n Si(H)Me n , n=0-3. Explanations for these phenomena are advanced. Such structural correlations allow the characterization of (Me 3 Si) 2 Si(H)Me a radical-based reducing agent with low hydrogen-donating abilities


The influence of humic substances (HSs) upon the alkaline hydrolysis of N-methyl- N-nitroso-p-toluenesulfonamidehasbeenstudied.Importantinhibitionofhydrolysisreaction has been reported. This inhibition has been explained in terms of association of reactants to the humic substances. Kinetic results have been modeled using the micellar pseudophase model. C


The Department of Rail Transport of the Silesian University of Technology conducted certification research of carbon composite materials provided by different manufacturers to be applied as pantograph strips. Additional tests were conducted apart from standard testing, as required by norms and regulations. These included amongst others laboratory test of the friction coefficient between the various materials used for pantograph strips and copper material used for overhead wires of the overhead line system. Apart from that bench testing was conducted in order to test the heating up of the overhead wire at different values of static contact pressure exerted by collector shoes. As part of own research measurements and observation with respect to the behaviour of the new pantograph strips and collector shoes were conducted in operating conditions. The research included amongst others the measurements of wear and forces between the pantograph strips and the overhead wire when in motion.


A two-dimensional Stefan problem is usually introduced as a model of solidification, melting or sublimation phenomena. The two-phase Stefan problem has been studied as a direct problem, where the free boundary separating the two regions is eliminated using a variational inequality (Baiocchi, 1977; Baiocchi et al., 1973; Rodrigues, 1980; Saguez, 1980; Srunk and Friedman, 1994), the enthalpy function (Ciavaldini, 1972; Lions, 1969; Nochetto et al., 1991; Saguez, 1980), or a control problem (El Bagdouri, 1987; Peneau, 1995; Saguez, 1980). In the present work, we provide a new formulation leading to a shape optimization problem. For a semidiscretization in time, we consider an Euler scheme. Under some restrictions related to stability conditions, we prove an L-rate of convergence of order 1 for the temperature. In the last part, we study the existence of an optimal shape, compute the shape gradient, and suggest a numerical algorithm to approximate the free boundary. The numerical results obtained show that this method is more efficient compared with the others.


Time‐resolved studies of network self‐organization from homogeneous solutions of the representative biostructural polymer agarose are presented. Solutions are temperature quenched and observed by several techniques. Consistent with previous suggestions by the authors, experiments at concentrations up to about 1.75% w/v provide direct kinetic evidence for the occurrence of at least two distinct processes, leading, in sequence, to self‐assembly. These are as follows: (a) a liquid–liquid phase separation of the solution occurring via spinodal demixing and resulting in two sets of regions that have, respectively, higher and lower than average concentrations of random‐coiled polymers; and (b) the subsequent 2 coils → double helix transition and accompanying cross‐linking and gelation (due to branching of double helices), occurring in the high‐concentration regions. The size of the high‐concentration regions depends upon agarose concentration and quenching temperature, and is in the range from a fraction of micrometers to a few micrometers, in agreement with earlier experiments. Bundling of the double‐helical segments is known to follow self‐assembly and can be considered as a third step (gel curing). This follows from the thermo‐dynamic instability of the helical segments in the solvent, behaving as a system of rod‐like particles connected by more or less flexible joints.


Alzheimer's disease (AD) is a chronic, and prevalent, neurodegenerative disease that leads to memory loss, especially in the elderly. AD is caused by a lack of acetylcholine in the brain and oxidative stress. The Cyamopsis tetragonoloba also known as Guar or cluster bean is a legume that belongs to the family Fabaceae. It is cheap, widely consumed as a seasoned vegetable, and reported to counteract chronic diseases linked to oxidative stress, such as diabetes, dyslipidemia, inflammation, and ulcer.

The present study was undertaken to assess the anti-alzheimer's activity of a tender green pod extract of Cyamopsis tetragonoloba on learning and memory impairment induced by scopolamine.

The extract's total phenolic and flavonoid content was determined using a UV-visible spectrophotometer. The Cyamopsis tetragonoloba methanolic pod extract (CTMPE) at a dose of 100 and 200 mg/kg and donepezil 2.5 mg/kg was administered orally for 7 successive days. On the seventh day, a single intraperitoneal injection of scopolamine was used to induce dementia. The behavioral experiments included an elevated plus maze, step-through passive avoidance, radial arm maze, and Y-maze tests were conducted. The mice were sacrificed and acetylcholine, acetylcholinesterase, and oxidative stress markers were measured in brain homogenate.

The total phenolic and flavonoid content was found as 12.9 mg of GAE/g and 1.71 mg of QE/g respectively. Scopolamine caused memory deterioration, as well as changes in acetylcholine, acetylcholinesterase, and increased oxidative stress in the brain. Mice pretreatment with CTMPE at both doses attenuated scopolamine-induced behavioral, neurochemical, and oxidative changes in a similar way to donepezil.

The CTMPE showed an anti-amnesic effect that makes it a promising candidate targeting multiple events as a potential strategy to curb the progression of cognitive impairment.


Many previous studies in multiple sclerosis (MS) have focused on the relationship between white matter lesion volume and clinical parameters, but few have investigated the independent contribution of the spatial dispersion of lesions to patient disability. In this study, we examine the ability of four different measures of lesion dispersion including one connectedness-based measure (compactness), one region-based measure (ratio of lesion convex hull to brain volume) and two distance-based measures (Euclidean distance from a fixed point and pair-wise Euclidean distances) to act as potential surrogate markers of disability. We use a set of T2-weighted and proton density-weighted MRIs of 24 MS patients, collected from a single selected scanning site participating in an MS clinical trial. For each patient, clinical status is available in the form of expanded disability status scale (EDSS) a standard measure of disability in MS. We segment all white matter lesions in each scan with a semi-automatic method to produce binary images of lesion voxels, quantify their spatial dispersion using the defined measures, then perform a statistical analysis to compare the dispersion values to EDSS and total lesion volume. We use linear and rank correlations to investigate the relationships between lesion dispersion, EDSS, and total lesion volume, and regression analysis to investigate whether there is a potentially meaningful relationship between lesion dispersion and EDSS, independent of total lesion volume. Our results show that one distance based measure, Euclidean distance from a fixed point, correlates with EDSS more strongly than total lesion volume (r = 0.57 vs. r = 0.47 for Pearson correlation), and has predictive value that is at least partly independent of lesion volume. The results suggest that for any two given patients with similar lesion loads, the one with greater dispersion would tend to have greater disability, but further experiments with larger data sets are required to confirm these findings.


The Internet has provided many opportunities for students to access online information to expand their knowledge at a fast pace. In most Sub-Saharan African countries, access to Internet services by high school students are most often limited. Moreover, accessing online information requires skills for effective search and retrieval. The study therefore investigated high school students in Ghana's Internet access and retrieval competencies. SHS 3 students from three high schools in Ghana participated in the survey. The study revealed that students had limited access to the Internet at school and also lacked the needed skills to efficiently and effectively access online information. The study recommends the need to improve Internet infrastructure and also train learners on skills needed for effective online search and retrieval.


Background: The health sector in Lebanon suffers from high levels of spending and is acknowledged to be a source of fiscal waste. Lebanon initiated a series of health sector reforms which aim at containing the fiscal waste caused by high and inefficient public health expenditures. Yet these reforms do not address the issues of health equity in use and coverage of healthcare services, which appear to be acute. This paper takes a closer look at the micro-level inequities in the use of healthcare, in access, in ability to pay, and in some health outcomes. Methods: We use data from the 2004/2005 Multi Purpose Survey of Households in Lebanon to conduct health equity analysis, including equity in need, access and outcomes. We briefly describe the data and explain some of its limitations. We examine, in turn, and using standardization techniques, the equity in health care utilization, the impact of catastrophic health payments on household wellbeing, the effect of health payment on household impoverishment, the equity implications of existing health financing methods, and health characteristics by geographical region. Results: We find that the incidence of disability decreases steadily across expenditure quintiles, whereas the incidence of chronic disease shows the opposite pattern, which may be an indication of better diagnostics for higher quintiles. The presence of any health-related expenditure is regressive while the magnitude of out-of-pocket expenditures on health is progressive. Spending on health is found to be "normal" and income-elastic. Catastrophic health payments are likelier among disadvantaged groups (in terms of income, geography and gender). However, the cash amounts of catastrophic payments are progressive. Poverty is associated with lower insurance coverage for both private and public insurance. While the insured seem to spend an average of almost LL93,000 ($62) on health a year in excess of the uninsured, they devote a smaller proportion of their expenditures to health. Conclusions: The lowest quintiles of expenditures per adult have less of an ability to pay out-of-pocket for healthcare, and yet incur healthcare expenditures more often than the wealthy. They have lower rates of insurance coverage, causing them to spend a larger proportion of their expenditures on health, and further confirming our results on the vulnerability of the bottom quintiles. Background Out-of-pocket spending on health is a major concern for policymakers, especially in developing countries where direct household payments for health care can account for the single largest component of household spending after food expenditures. High private health spending is related to the incidence of illnesses and chronic diseases, but it can grow exponentially and affect the living conditions of individuals in situations of crisis, conflict and natural disasters. These catastrophic health payments can push households into poverty or into deeper poverty. Households facing these health expenses may cut back on other essential household spending such as food and clothing. Households may also reduce their consumption of healthcare services, thus causing the health condition of family members to further deteriorate. To date, there has been little work done on the level and distribution of household out-of-pocket payments for health care in the Middle East, and to what extent household expenditures on health care affect living standards. Given that the region is prone to recurrent conflict and political instability, it becomes very important to determine who the most * Correspondence: firstname.lastname@example.com 1 Department of Economics, American University of Beirut, PO Box 110236, Riad el Solh, Beirut, 11072020, Lebanon Full list of author information is available at the end of the article BioMed Central © 2010 Salti et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Salti et al. International Journal for Equity in Health 2010, 9:11 http://www.equityhealthj.com/content/9/1/11 Page 2 of 21 vulnerable groups with regards to healthcare access and financing are. We focus in our analysis on the Lebanese economy, where health equity issues have not yet been thoroughly studied. The Lebanese healthcare system suffers from high spending: almost 8.8% of GDP compared to an average of 5% in the MENA region, of which 54% is private expenditure, 75% of those out-of-pocket. Most spending is geared towards hospital-based curative care, as the public sector expenditures on hospitalization accounts for more than 75% of total public health spending in 2006 [1]. Private sector hospitalization accounts for 48% of total public health expenditure, which constitutes a significant drain on public sector finances (Figure 1). Despite high spending, hospitals in Lebanon are still characterized by a low occupancy rate in public hospitals (56 percent in 2004 compared to an OECD average of 80 percent). The allocation of total hospital beds, which stands at 36 beds per 10,000 people, is highly skewed towards the capital and its suburbs, as these areas show a ratio of almost 70 beds per 10,000; while the poorer regions of South and Eastern Lebanon have a ratio below 20 beds per 10,000 [2]. In addition, health services in Lebanon are some of the most expensive in the region. One of the structural weaknesses in the Lebanese health care system is related to the fact that the role of the Ministry of Health has focused almost exclusively on the provision of services, while its role in prevention, planning and regulation remained limited. This is particularly true in light of the expanding role of the private sector (Figure 1). Both these factors also explain the prevalence of the more costly and arguably less effective culture of curative care rather than the more efficient strategy of preventive care in the Lebanese healthcare system. Recognizing the inefficiency of the health care sector in Lebanon, the World Bank initiated with the Lebanese Government under the Paris III reform framework a Social Protection Development Policy Loan (DPL) including several health sector reforms. The loan package comprises key reforms in the health insurance sector, measures to rationalize health expenditures, and critical reforms in public health policy. The public health reforms supported by the DPL consist of: i. Implementation, by the Ministry of Health of a health expenditure rationalization plan to better contain rising hospitalization expenditures. ii. Reform initiative to revitalize primary healthcare through the implementation of a five-year action plan based on a recently developed primary healthcare strategy for the country. iii. Reform initiative to fully develop and operationalize the national Expanded Program on Immunization (EPI). iv. Reform initiative to significantly upgrade the core public health function of disease surveillance. All these reforms are intended to contain the fiscal waste caused by high and inefficient public health expenditures (Table 1), in order to render the Lebanese healthcare system more cost-effective. Yet these reforms do not directly address the issues of health equity and coverage of healthcare services, which appear quite acute in Lebanon. These reforms are untargeted and do not specifically focus on communities with low access to healthcare and health insurance. In this paper, we propose a different reform approach than the one suggested by the World Bank, by focusing on health inequity. Health inequity can be defined as "a particular type of difference in health or in the most important influences on health that could potentially be shaped by policies; it is a difference in which disadvantaged social groups (such as the poor, racial/ethnic minorities, women, or other groups that have persistently experienced social disadvantage or discrimination) systematically experience worse health or greater health risks than more advantaged groups" [3]. Thus, inequity in health reflects the systematic differences across socio-economic groups in one or more aspects of health [4]. While the definition we use more closely matches the definition of health equity as equality in health, it is also consistent with the understanding of health inequality as an indicator of general injustice in society [5,6]. In recent years, rising global interest in the area of health equity has spawned numerous international research and policy initiatives [7]. These initiatives have largely focused on measuring and explaining inequalities in health status outcomes (infant mortality or maternal mortality), health service use (antenatal care visit), and Figure 1 Distribution of public health expenditure (2006). Source: Ministry of Finance 2006 budget proposal. 48%


The kicker magnet for extracting beam out of the Low Energy Booster is required to generate an integrated field of 0.06 T-m for 2 /spl mu/s, rising from 1% to 99% of peak in <80 ns. Technologies for pulsed magnets of this variety, along with the engineering tradeoffs of each, will be presented. Details of the electrical design of a vacuum-insulated 25-/spl Omega/ travelling-wave (TW) kicker magnet, with a 5/spl times/7 cm ferrite aperture, will be discussed. The results of low-voltage tests of the prototype TW magnet and a solid-core design will also be presented. Application of experimental data and design theory to the final magnet design will be mentioned.<<ETX>>


A current textbook in dermatology defines epidermolysis bullosa as a heterogeneous group of chronic, hereditary, blistering disorders which range from a mild inconvenience to a disabling illness with significant mortality. 1 Classification of this group of mechanobullous dermatoses is difficult because of the clinical over-lap of the various clinical types of epidermolysis bullosa, and the lack of adequate clinical or laboratory criteria for their differentiation. The findings by light microscopy are variable; conse-quently, the various types of this disease are not easily discernible. With the aid of the electron microscope, more accurate diagnoses have resulted. Since Pear-son's 2, 3 detailed classification of these mechanobullous dermatoses by electron microscopy, there have been relatively few reports which have confirmed the ultrastructural findings of epidermolysis bullosa. Because electron microscopy has not yet become readily available to everyone, published classifications based on these findings differ significantly and remain controversial.


575 Background: Cholangiocarcinoma (CCA) is a lethal hepatobiliary adenocarcinoma with increasing incidence and poor outcomes. Treatment success has been hindered by resistance, and new therapeutic strategies are necessary. The Src-family tyrosine kinase, LCK, activates Yes-associated protein (YAP), a known oncogene in CCA. While YAP has been historically difficult to target, we recently described LCK inhibition as a potential therapeutic option in CCA. We probed the LCK interactome employing biotinylation site identification technology (BioSITe) to discover molecular co-dependencies in the LCK-YAP axis. Methods: LCK-deficient HuCCT1, wild-type HuCCT1, and wild-type RBE cells were transfected with pEF-LCK-TurboID and used to reveal protein-protein interactions. Biotinylated peptides were enriched using anti-biotin antibodies followed by mass spectrometry analysis. Co-immunoprecipitation (Co-IP) was used to confirm interactions between LCK and identified interactors. Phosphoproteome profiling of human CCA tumors and patient derived xenografts was conducted to identify active kinase signatures in CCA. Tyrosine phosphorylated peptides were enriched using anti-phosphotyrosine antibody beads and analyzed by high-resolution mass spectrometery/liquid chromatography. Immunoblot analysis of HuCCT1 and LCK-deficient HuCCT1 cells was used to map the mechanistic interaction between LCK and epidermal growth factor receptor, EGFR. Inhibitors of EGFR and LCK, afatinib and NTRC 0652-0, respectively, were tested in vitro on human and murine CCA cell lines. Cell viability was determined with CellTiter-Glo; Calcusyn software was used to determine synergistic drug effects. Results: We discovered intracellular interactors of LCK in CCA using BioSITe. We identified both known and novel LCK interactors, including EGFR. Given that EGFR functions as a molecular driver of tumorigenesis and is increasingly recognized as a biomarker of resistance in a variety of tumors, we performed a phosphoproteomic evaluation of CCA tumors in which activated EGFR was identified by the presence of EGFR-Y1092, Y1197, and Y1172 phosphorylation. EGFR phosphorylation decreased under conditions of genetic LCK knock out and inhibition by NTRC 0652-0. Co-IP confirmed the interaction of EGFR with LCK. EGFR-Y1092 phosphorylation was downregulated with genetic knockout of LCK by immunoblot. Finally, EGFR inhibition was evaluated as a therapeutic strategy utilizing afatinib. Effects on cell viability were noted in both human and murine CCA cells. Afatinib and NTRC 0652-0 demonstrated a synergistic effect in vitro, with calculated combination indices of 0.007 – 0.790. Conclusions: A novel interaction between EGFR and LCK in CCA was identified using an unbiased proximity-dependent biotinylation technique. Dual blockade of LCK and EGFR is synergistic in CCA and may be a viable therapeutic approach for patients.


LoRa networks have been gaining ground as a solution for Internet of Things because of their potential ability to handle massive number of devices. One of the most challenging problems of such networks is the need to set the Spreading Factors (SF) used by the terminals as close to a uniform distribution as possible, to guarantee reliable transmission of packets. This can be tackled through stochastic allocations based on centralized strategies, and more recently some contributions proposed fully distributed approaches based on game theory. However, these studies still consider games of complete information, where users have full knowledge on each other payoffs. In reality, it would be more appropriate to extend these approaches to Bayesian games, as we propose to do here. More precisely, we extend the game theoretic formulation to a semi-supervised allocation, where the distributed character of the allocation is retained as the nodes still act independently in choosing their SF, based on what they think it is their best preferred choice. We also utilize the central gateway as a coordinator regulating these proposals and the interaction of the nodes with the coordinator is framed as a Bayesian entry game, where nodes exploit a prior to decide whether to join the proposed allocation or not. Under this framework, nodes reach a satisfactory compromise between the assignment they receive from the network and their desired rate.


I first met George Stigler in 1934 when we were graduate students at the University of Chicago. George, Allen Wallis, and our future wives-Margaret (Chick) Mack, Anne Armstrong, and Rose Director-were slated to form an intimate sextuplet that was to last the rest of our lives. The four of us who were economists literally breathed, ate, and slept economics, as graduate students are wont to do. For years, poor Chick and Anne had to suffer hours of talk about economics, economics, and economics, leavened by occasional digressions into statistics. As he was to remain, George was the life of the party. His quickness of mind, cleverness of repartee, and unmatched capacity for smart cracks, always with a point, enlivened every encounter, yet belied his seriousness of purpose. George, Allen, and I separated in 1935, but our paths crossed and recrossed. We came together again in 1944-45, when George joined Allen and me at the Statistical Research Group of Columbia University, which was engaged in advising and consulting with the military on a wide variety of purely wartime problems. Near the end of the war, George returned to Minnesota, from which he had been on leave of absence. He persuaded the department to offer me a position, which I gladly accepted. George and I shared an office that year-a delightful experience that remains a happy memory. The Stiglers, whose children were not far different in age from our own, were also our major social companions and entry point into the Minnesota community during that snowbound year. One day George came into the office nursing his elbow after slipping on the ice. I examined it carefully and solemnly pronounced it


Robotic systems for object handling and manipulation are hugely important for modern engineering and industry, with their efficiency, agility and robustness often depending on gripper design and performance. In this work, we investigate a gripper design that, when driven by a twisted string actuator, exhibits nearly-constant transmission ratio throughout its motion range. This allows for design of a highly-compact, modular and efficient robotic gripper driven by a low-power motor. We investigate kinematics of the device, experimentally verify developed models with a practical gripper testbed, and analyze transmission ratio and efficiency of the designed device. The resulting system has a nearly-constant transmission ratio of 550, with the constancy coefficient of 0.985.


Payroll or salary management is a process of retaliating an organization's services to employees as a person who contributes to achieving organizational goals. The length of the process of making paychecks and reports can hinder the employee payroll process. The purpose of the research is to build a payroll information system that is useful to assist the activities of permanent employees and teachers of educational foundations with case studies at the Yapim Educational Foundation in the North Jakarta area. The method used in this study uses the Rational Unified Process methodology with inception, elaboration, and construction phases. The results of this study are system designs in the form of system design diagrams and payroll programs. This research is limited to the stage of construction on the software engineering methodology and testing using the blackbox testing method with the Yapim Education foundation in North Jakarta as a sample of data retrieval. This payroll information system can facilitate the management of payroll in educational foundations and this system can be used in all educational foundations by changing the profile of the organization in the system.


groups living nearest the school. There was practically zero correlation between activity points and distance travelled to and from school. 13. May, Eric Oscar. A Comparative Study of the Achievement of Pupils from Rural and Village Schools in Crawford County, Illinois. September, 1927. Pp. 91. The problem of this investigation was to compare the pupils in the Township High School of Robinson, Illinois, who entered from village schools with those who entered from rural schools, on the following factors : age, ability as measured by the Terman Group Test of Mental Ability, achievement as measured by the Stanford Achievement Test, achievement as measured by the teachers' marks in high school, ability to remain in high school and to complete its work. In addition, the rural and village schools were compared on the following factors: number of pupils per teacher, training of the teacher, experience of the teacher, salary of the teacher, length of the annual school term, assessed wealth of the school district.


The relationship between the comic and the comedic is often obscured within the genre of dramatic comedy owing to the frequent conflation of the two terms. While the comic denotes a manner of portraying objects in order to evoke laughter, the phenomenon itself does not necessarily precipitate the comedic – a specific logic governing how incidents of action are arranged within a dramatic plot so as to provide a socially affirming, normalizing, or otherwise stabilizing resolution of the plot's conflicts. By investigating how comic elements and devices (as theorized by Henri Bergson) militate against resolution in Gerhart Hauptmann's 1893 comedy Der Biberpelz, this article argues that the work's structure allows us to explore the interaction and effects of the comedic and the comic within the discourse called comedy. This article concludes that the antagonistic interplay between the comic and the comedic within Hauptmann's comedy anticipates a postmodern sensibility. Most of Hauptmann's comedy unfolds as if it were a straightforward exercise of genre: a quick-witted washerwoman, Mutter Wolff, steals both firewood and a beaver coat from a wealthy citizen in a Berlin suburb, while a transplanted state official, Wehrhahn, gains his executive bearings and appears on track to expose Wolff as a criminal. It would seem only natural for such a comedy to conclude with the perpetrator being exposed and punished. Such a resolution – which this article calls a comedic resolution – would thus clarify the uncertainties of the plot, reinstate the balance of justice within the mimesis, and reinforce the social norms within the drama. Twice the arrangement of the comedy's plot suggests such an impending conclusion. Twice the settings shift from Wolff's house to the official's court; twice the wealthy victim, Krüger, comes to report the crimes; and twice the official Wehrhahn seems close to exposing and prosecuting the thief or, as critic Gert Oberempt views it, "[z]weimal geht die Rechnung, daß die Diebin entdeckt werden müsse, nicht auf" (150). That is, twice the work seems to signal an impending comedic resolution featuring the indictment of Wolff as the perpetrator, which would consequently restore the social and legal order while relieving the tension the crimes precipitated. But this relief never arrives, leaving a palpable void in the comedic process. With its absence, though, the missing comedic resolution provides substantial insight into the (mal)function of the comic in dramatic comedy.


It is urgent to realize creative aducation in philosophy education and cast off fixed and dogmatical teaching mode in teaching Marxism.


BARR, ARVIL S.; DAVIS, ROBERT A.; and JOHNSON, PALMER O. Educational Research and Appraisal. Philadelphia 7: J. B. Lippincott Co., 1953. Pp. viii+362. BLAIR, GLENN MYERS; JONES, R. STEWART; and SIMPsoN, RAY H. Educational Psychology. New York 11: Macmillan Co., 1954. Pp. xviii+602. $4.75. Children in Focus: Their Health and Activity. 1954 Yearbook, American Association for Health, Physical Education and Recreation. Washington 6: American Association for Health, Physical Education and Recreation, 1954. Pp. x+278. $3.50. Creating a Good Environment for Learning. 1954 Yearbook, Association for Supervision and Curriculum Development. Washington 6: Association for Supervision and Curriculum Development, National Education Association, 1954. Pp. xii+308. $3.75.


A film transducer head design is formed on a substrate where the first yoke layer and electric terminal strip that connects the coil center pad to the head exterior are formed at the same time followed by successive layers that form the transducer gap, coil insulation, coil, coil insulation and the second yoke layer. This sequence allows the coil to be tested immediately after deposition of the coil material and at a time in the fabrication sequence when it can be reworked or replaced if a discontinuity (open) or shorted turn(s) is (are) identified.


For the past ten years I have been engaged in taxonomie and phytogeographic studies of the marine algae of the Pacific coast of North America. Although it is planned to present the results ultimately as a floristic treatise, the completion of this project is so far from sight as to suggest the usefulness of publishing certain nomenclatural, taxonomie, and distributional notes at this time. All specimens cited in this paper are in the Herbarium of the University of California, Berkeley. Collections are mine unless otherwise indicated.


This research developed systems to measure mass-flow of hay and forage using a self-propelled
windrower, self-propelled forage harvester and large square baler in order to generate yield maps
of hay and forage production.
The windrower was used to collect mass-flow and yield data in alfalfa using system to measure:
(1) impact force at the swath forming shield; (2) crop volumetric flow past the swath forming
shield; (3) conditioning roll speed; (4) platform pitch; and (5) pressure of platform drive motor.
Some sensors systems were promising but even the most promising will require further evaluation
because the average absolute mass-flow prediction error and 90th percentile error were 13.4 and
26.4%, respectively, above the desired maximum of 5 and 10%.
The forage harvester was used to collect mass-flow and yield data in wilted alfalfa and wholeplant
corn silage using systems to measure: (1) feedroll displacement; (2) crop impact force in the
spout; (3) blower speed; and (4) depth of material in the spout. The accuracy of these sensors was
much better in whole-plant corn silage than in wilted alfalfa, primarily because the former fed
much more uniformly. The average absolute and 90th percentile errors were 12.3 and 24.2%,
respectively, for wilted alfalfa, and 4.4 and 7.4%, respectively, for whole-plant corn silage.
The large square baler was used to collect mass-flow and yield data in dry alfalfa using sensor
systems to measure: (1) bale velocity; and (2) dynamic bale weight on the chute. The bale
velocity and weight measurement systems were excellent at predicting mass-flow with typical
absolute and 90th percentile errors of 1.4 and 3.2%, respectively.
Multi-parameter regression models were developed to predict mass-flow for each of the three
machines. These models were then used to create yield maps using the output from selected
sensors. The resolution of the yield maps was a function of the width of the harvested strip. The
resolution of the yield maps was the best with the windrower and forage harvester in whole- plant
corn silage because these machines had the narrowest harvesting widths. The map resolution was
less with the forage harvester harvesting wilted alfalfa and with the large square baler because
multiple windrows were often merged together to meet the capacity needs of the machines. The
developed yield maps were quite capable of showing spatial differences in yield that corresponded
very well to differences in elevation, soil type, traffic patterns and fertility. The hay and forage
mass-flow sensor systems and yield mapping systems should become a valuable precision farming
tool.


One of the objectives of the Paris Peace Agreement of 1973, expressed in Article 22, was to "create conditions for establishing a new, equal, and mutually beneficial relationship between the United States and the Democratic Republic of Vietnam" (DRV). The Agreement failed to accomplish that objective and more than two more years of war ensued in which the U.S. was deeply involved through its client govern ment in Saigon. Even with the termination of the war in April 1975 and, hence, the end of U.S. intervention in Vietnam, the new relationship promised in the Pans Agreement was still not accomplished. Instead, U.S.-Vietnam relations have remained in an ambiguous status between overt hostility and real reconciliation. The basic policies of both Vietnam and the U.S. on postwar relations have emerged from the period of the Pans Agreement, from 1973 to 1975. The Vietnamese had anticipated the problem of transition from war to friendly relations with the U.S. and had tried to work into the Paris Agreement a way for the U.S. to abandon gracefully its past all-out opposition to the Vietnamese revolution and to adopt a more balanced relationship with the parties to the conflict. Kissinger rejected such a course and pursued a policy of war until the very last days of the Saigon r?gime. Then he refused to accept the defeat which that policy brought for the U.S. What happened to the Paris Agreement and the goal of U.S.-DRV reconciliation is thus an important part of the story of postwar relations.


Tourism has been developing into the largest sector in the world and Sikkim, Indian Himalayan state has increasingly become a popular tourist destination for both domestic and international tourist/visitors in India. The sustainable tourism industry has the potential to contribute to the economic development of Sikkim. Therefore, this paper attempts to analyze the factors contributing to sustainable development of tourism in Sikkim such as, inbound tourist, types tourist arrival, the number of tourist arrivals from seven important generating countries, and neighbor states, effect of seasonality of tourist arrival, duration of stay and home stay facilities to tourist in Sikkim. The study comprises of questionnaire surveys and group discussions with the different stakeholder in the study site, Department of tourism, including International and Domestic tourists, guides, operators, hotel and lodge operators. Two peak seasons (spring and autumn) were chosen following the in-depth interviews and survey questionnaires of 250 visitors in the study. Educated young visitors with higher income prefer to visit Sikkim more than another group of visitors. Tourist arrival in Sikkim shows some seasonal variations. Tourist visits to the Sikkim takes place throughout the year, but rapid increase in number occurred from March and reach to peak in May of every year. The state has benefitted from tourism in different sector as it provides employment in the form of transport operator, guides of tourist, cooks, porters, hotel, restaurant, transportation, promotion to indigenous cottage industries. The number of tourist arrivals has been increased together with the gradual increase in the numbers of hotel and travel agencies in the mountain state. Development of infrastructure, political stability, implementation of good tourism policy, construction of the road, and opening of new tourist destinations and proper campaigning of a tourist destination in the world and to highlight its attractiveness are seen as the main contributing factors in the region. Lack of regular monitoring and evaluation of culture and environment of the state will be the major cause of future destruction. Proper planning, regulation and review of experience as well as the market-based experience of the industrialized country such as South Korea is required to develop Economically and environmentally sustainable tourism.


Frailty and decreased functional status are risk factors for adverse kidney transplant (KT) outcomes. Our objective was to examine the efficacy of an exercise intervention on frailty and decreased functional status in a cohort of patients with advanced chronic kidney disease (CKD).


The software error compensation in CNC machining centers on-line inspecting system was investigated.Based on Windows 2000 operating system,compensation software was developed.The software can compensate probe errors,thermal and geometric errors.The software system was tested on MAKINO upright CNC machining centers,and the results verified the effectiveness of the method.


performed after CA. 1 ml of Epi (0.2mg/kg) and 1 ml of Vaso (0.8U/Kg) were administered. The rats in control group exhibited the lowest survival rate and therefore were abandoned in the following experiment. The rats survived from other groups were killed in 1, 3, 6 and 12 hours after CPR, respectively, and the brains were taken out. We tested the expression of NF-κB in rat's hippocampus by immunohistochemistry. The restoration of spontaneous circulation (ROSC) rate was recorded and the pathological changes of the brains were observed in each group. Results: Compared to Epi group, the expressions of NF-κB in Vaso group and combination group were lower (P<0.05). No significant difference was seen between Vaso group and combination group (P>0.05). HE staining demonstrated there was no difference in morphology changes among Epi, Vaso and combination group under light microscope. Compared to Sham-operated group, the edema of neurons in Hippocampus was seen in the other three groups. The damage of Mitochondria was more serious in Epi group than in Vaso and combination group under electron microscope. No difference of Mitochondria damage was seen between Vaso and combination group. Conclusions: Vaso can alleviate cerebral ischemia reperfusion injury during CPR and suppress the expression of NF-κB in Hippocampus of rats with CA after asphyxia.


Watershed environments play an important supporting role in sustainable high-quality economic development in China, but they have been deteriorating. In order to solve environmental problems in the Poyang Lake River Basin brought about by economic development, the Jiangxi Provincial Government promulgated relevant river basin protection policies in 2015. However, after several years of this policy, the specific effects of its implementation are a matter of general concern to the government and academic circles. After years of policy implementation, the implementation effect of the watershed ecological compensation policy needs to be evaluated. Based on 4248 observations from the Jiangxi and Hunan Provinces, we adopt the difference-in-difference method to analyze the impact of the ecological compensation policy on the Poyang Lake River Basin. The empirical results show that the ecological compensation policy has a significant effect on water-quality improvement. Water quality in the upstream area is better than that in the downstream area; areas with small administrative areas have a smaller population, which in turn leads to better water quality in the river basin; and the higher the per capita GDP, the worse the water quality. Our results highlight the need for the following policy improvements: ecological priority, customizing measures to local conditions, tracing the main body, and strengthening supervision.


The two most compelling problems facing the IP Internet are IP address depletion and scaling in routing. This paper discusses the characteristics of one of the proposed solutions---address reuse. The solution is to place Network Address Translators (Nat) at the borders of stub domains. Each Nat box has a small pool of globally unique IP addresses that are dynamically assigned to IP flows going through Nat. The dynamic assignment is coordinated with Domain Name Server operation. The IP addresses inside the stub domain are not globally unique---they are reused in other domains, thus solving the address depletion problem. The pool of IP addresses in Nat is from a subnet administered by the regional backbone, thus solving the scaling problem. The main advantage of Nat is that it can be installed without changes to any existing systems, although FTP will fail in some but not all cases. This paper presents a preliminary design for Nat, and discusses its pros and cons.


Discourse markers ('cue words') are lexical items that signal the kind of coherence relation holding between adjacent text spans; for example, because, since, and for this reason are different markers for causal relations. Discourse markers are a syntactically quite heterogeneous group of words, many of which are traditionally treated as function words belonging to the realm of grammar rather than to the lexicon. But for a single discourse relation there is often a set of similar markers, allowing for a range of paraphrases for expressing the relation. To capture the similarities and differences between these, and to represent them adequately, we are developing DiMLex, a lexicon of discourse markers. After describing our methodology and the kind of information to be represented in DiMLex, we briefly discuss its potential applications in both text generation and understanding.


In 2013 research work in Baalbek had to be re-organized due to increasing political crises in the wider region. In close cooperation with Lebanese researchers, an excavation in the famous quarry in the south of Baalbek has been carried out aiming at collecting hints for quarrying and transportation techniques for the monumental blocks. Unexpectedly, an even larger block came to light that has to be considered the largest block ever cut in antiquity. Between 2001 and 2011 a comprehensive research project was carried out in Baalbek for the documentation of excavated but not yet published archaeological architectural remains and findings. It aimed at investigating the urban development of the town from its beginning until present. Parts of its results have been published and made public in a WebGIS. In addition, a feasibility study for conservation work has been developed.


Polysaccharides are the most abundant natural biopolymers and represent by far the largest group of polymers produced in the world: indeed more than 150,000 M tons of polysaccharides per year are produced in comparison with about 140 M tons of synthetic polymers (Navard, 2005). Polysaccharides are widely diffused in nature: they can be found in plants, animals and microorganisms, performing different fundamental biological functions. Depending on their functional role, they can be distinguished in: energy reserve substances (e.g. starch or inulin in plants, glycogen in animals), structural elements maintaining mechanical shape and rigidity of the living cells (cellulose, hemicellulose and pectin in plant cell wall, chitin in arthropod exoskeletons), and water-binding elements (agar, pectin and alginates in plants, mucopolysaccharides in animals). About 99% of total natural polysaccharides are located in plants and vegetables that consequently represent a major renewable source of these biopolymers exploitable for different purposes. Indeed, polysaccharides are presently used in all sectors of human activities and in several application such as: food nutrients, food additives and feed production; material science concerning the formulation of polymeric materials for different biotechnological applications; health care for biocompatible materials, drug delivery or as source of biologically active molecules; sustainable energy production by means of biofuels generation (Persin et al., 2010). The main and most abundant polysaccharides from plants and vegetables include starch, cellulose and hemicelluloses, inulin and pectins that, thanks to their useful physicalchemical properties such as emulsifying power, viscoelasticity, polyelectrolyte conformation, adherence, bio-compatibility, stabilizing power, et cetera are usually exploited in the above mentioned fields of application. In addition, several other polysaccharides with different structures and properties are continuously isolated and are under investigation in relation to their features and potential employment in several industrial sectors.


Background and Objectives: With the development of medical imaging and computational fluid dynamics (CFD), a fast calculation method of steady-state fractional flow reserve (FFRss) based on CTA images has been applied to predict myocardial ischemia. Whilst this is a reliable non-invasive method of calculating FFR, assumptions involved in the analysis still need to be investigated for further improvement in predictive accuracy. In this study, we analyzed the influence of inlet and outlet boundary conditions on FFRSS.Methods: A clinical trial was carried out in Peking University People's Hospital. We enrolled 15 patients with coronary heart disease. All patients underwent coronary CTA examination, aortic pressure measurement and FFR catheter surgery. In order to better reflect the relationship between different entrance boundary conditions and FFRss, we used the invasive measurement of FFR as the standard, and calculated FFRss for 15 patients with coronary heart disease with different degrees of stenosis. The boundary conditions are divided into two groups: (1) pressure calculated based on physiological formula; (2) clinically measured aortic pressure. Based on the boundary conditions calculated by the physiological formula, we further studied the changes of FFRss under different coronary vasodilation responses (12%-48% baseline).Results: The research results show that although the pressure difference between the two pressure boundary conditions is 15mmHg, the FFRss calculation result does not change significantly. With the change of the vasodilation state, the microcirculation resistance of the exit boundary condition gradually increased, and the calculated FFR value increased.Conclusions: We found that changes in the microcirculation resistance of coronary stenoses have a huge impact on FFRss. The changes in FFRss values caused by boundary conditions are due to the overestimation of the vasodilation response. Therefore, individualizing the hyperemia state of the stenotic vessel microcirculation resistance value is an effective method to improve the calculation of FFR.


Using the blood of a subject, provides a more objective and quick way to determine the severity of pneumococcal pneumonia. Pneumonia to pneumonia in blood of which was collected from the subject bacteria or absence of antigen, and serum C-reactive protein level (CRP), white blood cell count (WBC) and biochemical test values at least one selected from a blood urea nitrogen concentration (BUN) used as an index determining how the severity of Streptococcus pneumonia.


OBJECTIVE
To investigate the association of nuclear factor-kappaB (NF-kappaB) and intercellular adhesion molecule-1 (ICAM-1) with endometriosis.

METHODS
Immunohistochemistry was used to examine the NF-kappaB and VEGF protein expression in 35 specimens of normal endometrium, 48 eutopic endometrium of endometriosis and 76 ectopic endometrium, and the results were analyzed statistically.

RESULTS
The expressions of NF-kappaB and ICAM-1 were found mainly in the glandular epithelial cells of the three endometrium specimens, with the ectopic endometriotic tissues showing the highest and normal endometrium the lowest expressions (P<0.001). NF-kappaB and ICAM-1 expressions were positively correlated to normal, eutopic and ectopic endometrium (r=0.688, 0.773 and 0.777, respectively, P<0.01).

CONCLUSION
NF-kappaB and ICAM-1 may participate in the process of the pathogenesis in endometriosis.


ABSTRACT How has the post-2015 democratic rollback in Poland impacted its support for the democratization of Ukraine and Belarus? Conventional wisdom is that countries undergoing autocratization would abandon democracy promotion. In contrast, we provide evidence that even as democracy was undermined at home, Poland continued to provide democracy support abroad, albeit less enthusiastically. We further document that it was not the normative commitment of Polish elites to democracy but the instrumental embeddedness of democracy promotion in Polish foreign and security policies that ensured its survival. Lastly, we find that Poland's support for democracy abroad now is closer to the new conservative values promoted at home, implemented mostly through state-run or state-controlled programs and less focused on supporting civil and political society abroad. Our paper contributes to the literature on regime promotion by analyzing and theorizing the overlooked question of how foreign policy, including democracy promotion, shifts for countries undergo autocratization.


It is difficult for clinicians to evaluate the severity of a patient's drinking behavior at a given point in time. This large retrospective study


Anthropocentrism takes human as universe centre and the measure of value judging everything.During modern times,humen take advantages from using technologies to serve ourselves,and survive in the condition of developed technologies.But the development can be seemed as the aliened external strength as the intemperate wasting itself,and forces people lose their freedom.


Crifchley, M.: Nervous disorders in boxers. The Medical Annual 55: 318,1937. Darrow, C . W., and Pufhman, 1. H.: Relation of heart rate to slow waves in the electroencephalograni during overvenlilation. Am. J. Physiol. 140: 583, 1944. Damson, R . E., W e b s f e r , J . E., and Gurdjian, E . S.: Serial electroencephalography in acute head injuries. J. Neurosurg. 8 : 613, 1951. Denny-Brown, D.: Cerebral concussion. Physiol. Rev. 25: 296, 1945. Denny-Brown, D.: Disability arising from closed head injury. J.A.M.A.


Discloses a packaged MEMS device and methods for MEMS device package calibrating. In one embodiment, the packaged MEMS device comprises a carrier, provided MEMS device on a substrate, the signal processing device is provided on the carrier, the validation circuit is provided on the support; and provided on a support seal, wherein the seal the MEMS device, the signal processing device and a storage element sealed.


Control System for the IFMIF/EVEDA Prototype Accelerator consists of six subsystems; Central Control System (CCS), Local Area Network (LAN), Personnel Protection System (PPS), Machine Protection System (MPS), Timing System (TS) and Local Control System (LCS). The Prototype Accelerator provides the deuteron beam with the beam power more than 1 MW, and this control system is required the high reliability and usability to perform various operation modes for beam commissioning. To satisfy these requirements, we are developing mainly PPS, MPS and TS at the beginning. This paper presents the status of hardware development of the PPS, MPS and TS.


Objective To study the characteristics of the B - scan images order to improve the diagnostic level on tumors. Methods To compare the results of B - scan images of the tumor inumors in 92 cases with surgery and pathology. Results (1)There were 61 cases with malignent masses(66.30%)and 31 cases with benign masses(33.69%) confirmed by pathology. (2)The coincident rate were 93.47%(86/92) .Conclusion It was valuable in diagnosis and differential diagnosis for abdominal masses with B - scan.


Large-scale data mining and deep data analysis are in high demand in modern enterprises. This work describes the RABID (R Analytics for BIg Data) framework to provide a highly parallel R. We achieve the goal of providing data analysts with an easy-to-use R interface to effectively perform deep data analysis on clusters by integrating R and a MapReduce-like platform. By leveraging a distributed runtime system, our framework enables R, the single-threaded language, to efficiently perfrom parallel analysis of data that cannot fit into a single shared memory machine in parallel. Experiments of data mining benchmarks on our framework show promising results.


The utility model relates to a crawler type vacuum low temperature drying machine, and especially relates to a conveyer belt rectification device for a crawler type vacuum low temperature drying machine, the conveyor belt rectification device comprises a material conveyer belt, one end of the material conveyer belt is provided with an adjustable transmission shaft, the edges of both sides of the material conveyer belt are respectively provided with a fiber displacement sensor, the two ends of the adjustable transmission shaft are respectively provided with a rectification controller, the two rectification controller and the two fiber displacement sensor are respectively in signal connection with the central controller of the drying machine. Compared with the prior art, the conveyor belt rectification device in the utility model uses the fiber displacement sensor to perform the real time detection upon the position of the conveyer belt, and can perform the rectification immediately when the conveyer belt offset appears, guaranteeing the normal track of the conveyer belt operation, thereby guaranteeing the normal running of the drying machine.