Core of the organizations data is available in the back end server. Securing the data from unauthorized people and transmitting the data to the authorized person through a secure route is the aim of the organization. A protective model for back-end servers is accomplished by the novel combination of honeypot deployment, honeypot masquerading, and strict authentication for backend server access. In our approach, a solution that has been catching on in the network security and computer incident response environment is to employ "Honey Pots." Honey Pots, also known as deception systems, honey-pots or tar-pits, are phony components setup to entice unauthorized users by presenting numerous system vulnerabilities, while attempting to restrict unauthorized access to network information systems. These features include suspicious event alerts to a management workstation for visual and audible notification, the ability to capture the unauthorized user's keystrokes and send it to a remote server, various customized logging and bogus system files and information to have the unauthorized user waste time as the security administrator prepares a counter measure. Honeypot A honey pot is a decoy computer system designed to look like a legitimate system an intruder will want to break into while, unbeknownst to the intruder, they are being covertly observed. Honeypots are effective precisely because attackers do not know if they are there and where they will be. However, honeypots are also a controversial technique; they essential bait and capture intruders skirting the fine line between keeping attackers out of a network versus inviting them in. Little legal precedent has been established. Some see them as unfair entrapment tools while others see them as an effective data gathering and deterrence mechanism. A honeypot is a program that takes the appearance of an attractive service, set of services, an entire operating system, or even an entire network, but is in reality a tightly sealed compartment built to lure and contain an attacker (a sandbox where intruders cannot harm production systems or data) – effectively shunting an intruder safely from production systems for covert analysis. Like a hidden surveillance camera, a honeypot monitors and logs every action an attacker makes including access attempts, keystrokes, files accessed and modified, and processes executed. We are implementing in our project in Java, based on client and server technology. We are also deployed the cryptographic procedure for maintains the security. In this concept, the alternate path selecting is main factor for eliminate the intruder in the network and also utilize the network in better manner. Honey Pots are considered "set and forget" IDS sensors, because they are composed of a single system or network of devices whose sole purpose is to capture unauthorized activity. As a result, they are able to download free tools that will scan many different networks looking for those easy-open entry points. Employing Honey Pots takes advantage of these traditional issues and uses it for its enticing benefit. They are constructed to sting hackers, not just keep them out. Honeypot technology has concentrated on emulating vulnerable operating systems, applications and services to capture attackers and analyses their methodologies. In recent years, the surge of Internet worms has created a new use for this technology. Many experts predict that attacks targeting Windows file sharing will increase significantly. Current Intrusion detection system have the ability to detect intruders once the attack has already occurred. This often gives little information on what has actually been done. Honeypots, while being a relatively new technology, can generate very good data on attacks. All traffic occurring on and around a properly set up honeypots is logged. Current weakness in misuse intruder detection system include the fact that new attacks are not detected until someone has generated a rule or signature that pick up that specific attack and the most attack, need only be slightly altered in order to bypass existing rules. Honeypots used to detect and report on new attacks. It may be automated, saving time and catching new attacks as they happen. A honeypot is a fictitious vulnerable IT System deployed to be probed, attacked, exploited and compromised. Generally it consists of a computer, data or a network site that appears to be a part of a network but which is actually isolated and protected, and that which seems to contain information or a resource that would be of value to attackers. An example of a honeypot is a system used to simulate one or more network services that you designate on your computer's ports. An attacker assumes that you are running vulnerable services that can be used to break into the machine. This kind of honeypot can be used to log access attempts to those ports including the attacker's keystrokes. Implementation Issues Several issues arise with deployment of this protocol in practice. While the protocol is light to each client, inducing only slight overhead to assign permissions and forward authenticated client session information to the router Rm, this overhead across all clients on the implementation in the ns-2 network simulator was to determine the attack load required to balance this overhead. A second issues is the devotion of system resources to the handling of honeypot communication. It is possible for an attacker to flood the honeypot with request messages from different IP address sources. It is the duty of Rm instead of H to update the AS with misbehaving traffic alerts should the messages overflow the H queue. The flexibility provided by the use of the masquerading router ISSN: 2278-5183 International Journal of Computers and Distributed Systems www.ijcdsonline.com Vol. No.2, Issue 1, December 2012 22 |a g e w w w . c i r w o r l d . c o m provides a greater possibility for deployment and success of the honeypot as a decoy device as well as better insulation for the true back0end server from malicious traffic.Typically, a honeypot involves simulation of either a network server or port containing valuable or sensitive information that would be attractive to an attacker. Honeypots are not intended for use by legitimate network traffic, so any traffic received can immediately be recognized as malicious and further action can then be taken. Such honeypots can interact with the attacker to a pre-defined extent to gather information on the types of attacks being deployed against the network. The power of these honeypots lies in their exploitation and ability to gather information on attacks. Static honeypots have the weakness of detectable location which can allow an attacker to simply avoid the honeypot and continue to a potentially significant target. Alternate forms of honeypots have also been proposed, ranging from honeynets to the virtual honeypot scheme. Honeynets are simply a collection of honeypots deployed throughout a network to increase the likelihood of an attacker reaching one on an unfocused search. In a similar idea to honeypots, the concept of a honeytoken has also been proposed as a trap for malicious clients; honeytokens are programs or files that attract the attention of malicious clients on a smaller scale than honeypots, taking the form of enticing links or e-mail messages. This is a lightweight system that simulates multiple low-interaction honeypots on a single network card, capable of simulating the stack of multiple operating systems, a key component by which attackers can determine the signature of a system and therefore continue to press attacks which can later be analyzed . However, the low-interaction of each simulated honeypot can be detected and avoided just as a physical honeypot. The shadow honeypot is a means of detecting and deterring anomalous traffic by rerouting it to a state limited production environment that can be rolled-back. The design for this system is based on the possibility that some traffic will be mislabeled as anomalous and can then be serviced transparently provided it does not exhibit malicious behavior. While this system is effective for combining the honeypot decoy system with anomaly detection, it requires a great deal of configuration and adaptation based on network traffic patterns. It also requires the use of a separate controlled simulation of the production environment, which may be an extensive undertaking depending upon the complexity of back-end services. Two requirements provide protection against DoS attacks in this scheme; First all traffic is dropped when a server switches from active to inactive (acting as a honeypot) and second any traffic that hits an inactive honeypot is filtered from further communication within the network [10]. There are several limitations to this scheme. First, the back-end servers must be able to seamlessly switch states with each other, meaning this type of approach is only suitable for systems without a large possibil ity for state change and easy TCP/IP migration from server to server. In the absence of this, the complete server image would have to be migrated to the new server connection, inducing tremendous client delay. Secondly, there is a significant waste of resources by allowing active servers to act as decoys. Third, this scheme actually violates the definition of honeypot usage, which mandates the uninterrupted operation of the network with the honeypot attached. There is additional risk in the possible compromise of an active back-end server while it is acting as a honeypot. While this protocol provides for the periodic cleanup of source code on the back-end server, a complete server re-image would be required at each switch from the inactive state to the active state, termed an epoch ; this would again induce a tremendous amount of client delay. This paper does suggest the idea of logical roaming without further expansion ;it is


Internet and information technology are creating a new opportunity for consumers to share their product evaluations online (Avery, Resnick and Zeckhauser 1999). Amazon.com started to offer consumers an option to post their comments on products on its website in 1995. Currently, Amazon.com has about 10 millions consumer reviews on all its product categories, and these reviews are regarded as one of the most popular and successful features of Amazon (New York Times, Feb. 24, 2004). In recent years, an increasing number of online sellers (e.g., BevMo.com, BN.com, cduniverse.com, circuitcity.com, GameStop.com, computer4sure.com, c-source.com, half.com, goodguys.com, wine.com) are adopting the same strategy. These online sellers invite users of their products to post personal product evaluations on the sellers' websites or provide their customers consumer review information offered by some third-party sources such as Epinions.com and CNET.com. Online consumer reviews are common for many product categories such as apparel, books, electronics, games, videos, music, beverages, games, and wine. Small business is often regarded as entrepreneurship-driven.
There are many reasons for this, e.g.:
(1) The entrepreneur and leader as a person plays a much more vital role than in large firms and,
(2) entrepreneurial and leadership spirit are not weakened by considerable hierarchies and can more easily pervade the firm.
Welsh & White's (1981) statement on the differences between small and big business seems to apply. Management research, in particular in the area of small business, is by now not sufficiently linked with entrepreneurship theory. However, entrepreneurship theory offers a lot regarding the evolutionary management of SMEs. It is the intention of this conceptual and theory-based paper to scrutinize this linkage and to identify useful insights for the leadership management of SMEs. Leader itself can be identified as the person who leads or commands a group, organization, or country. Even though defining a leader by the existence of followers has a long tradition, but it is not useful in attempting to improve the leadership of organizations. However, we define "leader" as an ordinary human being with both a commitment to produce a result whose realization would be extraordinary given the current circumstances as seen by the participants, and the integrity to see this commitment through to its realization. In this study, we investigated one mechanism of action, exploring how the consistency of transformational leadership effectiveness across hierarchical levels influenced the implementation of a strategic initiative in organizational change management. The research concludes that a multi-functional approach of transformational leadership that fits the managerial challenges of the small business best.


Organizing and managing policy documents (PDs) issued to the public in a good way can improve the efficiency of government employees and make it easier for the public to find the needed policy information. However, existing PDs are organized only by dates and manually defined categories; besides, PDs issued by different government branches are isolated from each other. These problems make it challenging and time‐consuming for the public to find the needed policy information. We argue that implicit links should be established between PDs based on their relevance, thus helping the public find the needed policy information efficiently. To this end, we propose an unsupervised relevance scoring method for PDs consist six modules, taking Chinese social security policies as the application case. The method combines the TextRank algorithm, TF‐IDF representation, mutual information and left–right information entropy algorithm, and BERT. The method can decrease the interference of noisy words in PDs to relevance scoring. In addition, the method can consider multiple features of PDs simultaneously so that the measure of relevance can be more comprehensive. The method is not driven by domain‐specific labelled data, hence can be easily generalized to PDs in various domains. We construct a dataset containing 5000 Chinese social security policies and then conduct experiments on it to evaluate our method. Experimental results show that our method is feasible and can bring convenience to government agencies and the public to a certain extent. Furthermore, our method achieves more than a 3% improvement in evaluation results on test tasks than the methods with a similar purpose in the legal AI community.


Islamic finance has made a tremendous progress due to the technological revolution. Islamic finance which was only a concept till few years ago is now emerging a separate discipline and many departments are established in top universities in the world. Based on the growth and demand of Islamic finance, it is expected to be a separate discipline in a decade like economics and finance. From the last few years, many educational institutions and research organizations have developed separate branches for the research in Islamic Finance and are publishing more than 14 peer-reviewed journals. Also academicians have developed interest in publishing their high quality research work in SCOPUS and Web of Science indexed journals. These two databases have indicated that there is an upward trend at an increasing rate in publishing the high quality research papers in Islamic Finance. In this paper, number of research papers published in Islamic finance which are indexed in Scopus and Web of Science have been covered from 2000-2016, to highlight the progress of Islamic finance publications for predicting its future well. The paper also highlights the growth rate, articles indexed, yearly data of papers, number of papers, author score, university/institution score and country score of Islamic finance of Web of Science in general and Scopus in particular.


In the variceal ulcer acupuncture treatment was to be effective as a complementary therapy in the 80% of the cases treated.


For the design of underground structures in rocks, the states of initial stresses in the rock mass are required. For structures located at great depths, the hydraulic fracturing test for stress mea...


This paper firstly introduced the characteristics and technical advantages of ADS40 aerial digital sensor.Then it discussed the procedure of aerial data acquirement of ADS40.It emphasized on the work flow and application of DLG production using DOM.


The invention discloses a vacuum isolating valve. A valve rod is coated with a corrugated pipe, and two ends of the corrugated pipe are connected onto a bonnet and a valve core through welding; a layer of zinc is arranged on the outer circular surface of the valve core through electroplating; a valve column, a limiting plate and a pipeline are connected in an integrally molded manner; the bonnet and a valve body are connected through welding; an outer thread is arranged at the lower end of the outer circular surface of the valve rod, an inner thread is arranged on a step of the valve core, the valve rod and the valve core are connected in a threaded fit manner, and then the connection position is fixed through welding again; an outer trapezoidal thread is arranged at the upper end of the outer circular surface of the valve rod, an inner trapezoidal thread is arranged in the middle of the bonnet, and the valve rod and the bonnet are matched with each other through the trapezoidal threads. The vacuum isolating valve is compact in design and reasonable in structure and adopts the integrally-molding fixed connection method, so that the rigidity of the whole valve can be improved, and the vacuum loss can be avoided after long-term usage; the vacuum isolating valve is simple in structure, economical in manufacturing cost, lower in difficulty for an operator and applicable to large-scale popularization.


Russian-Pakistani relations during its existence from 1948 (before the collapse of the USSR the Soviet-Pakistan relations) had a lot of ups and downs. This article focuses only on our relationship in the XXI century. In the first decade of this century, after many years of stagnation, there are evident positive prospects for the development of multilateral relations between Russia and Pakistan.


Letter from U.S. Army General W. C. Westmoreland to Colonel E. P. Fleming congratulating him on the 11th anniversary of the United States Army Primary Helicopter Center. The General commends the Colonel on the the Center's work and touches on the war in Vietnam. On the back of the letter is a stamp giving the Boyce-Ditto Public Library's address.


Gayl jones and toni morrison convey a completely different representation of afro-american women in american letters. The long-accepted american stereotypes related to sex and gender are challenged by them through their revisionary treatment of american history in the public and private lives of their heroines. (re) membering for them is at once a necessary and complex process of getting at the truth concerning african-american women. These writers present portraits of "arrested" or "emerging" black women beginning with the period of the "peculiar institution" through to presentday america. Gayl jones insists on the psychological and physical damage suffered by black women whereas toni morrison suggests in her narratives the potential for building a new jubjectivity which involves risk but offers the means to explore the redemptive possibilities of female coalescence. Both authors have inaugurated new forms of writing which incorporate their black oral tradition. Taking their inspiration from the blues -their lyricism, sheer strength, concentration and poetic qualities- gayl jones' heroines sing who they are and where they come from. Toni morrison writes her fiction using a highly metaphorical prose which comes close to the magic realism of garcia marquez.


1xN (N=2, 3, 4) MMI power splitters were fabricated in a fused silica substrate by laser direct writing, using a focused 515 nm amplified femtosecond laser beam, and characterized at 1550 nm. To accomplish this, several low loss waveguides were fabricated side by side to form a multimode waveguide with the output in a polished facet of the substrate, while a single low loss waveguide was fabricated to inject light in the centre of the multimode waveguide. The performance of the fabricated devices was optimized by testing three different designs.


The article describes features of the Russian emphatic models related to scientific style of speech and it is proved that they are able to develop several topics in the microtext, empower a phrase and convey its pragmatic content, form a certain emotional mood, set a communicative attitude to comprehend the utterance in a new perspective, focus recipient's attention on the emphatic segment, important in a particular situation for the perception of this or that information. The analysis allows us to conclude that emphatic models in the scientific style are communicatively dissected sentences, due to text links and having an existential meaning that creates an evaluative nomination. This emphase property makes it necessary to study it in a foreign audience in classes on the scientific style of speech and to master the skills of its use by foreign students. The correct perception of intonation or accentuation of a phrase segment (emphase) determines the level of development of foreign students' monological speech skills which are necessary due to their communicative needs not only in the socio-cultural, but also in the educational and professional spheres. Complex syntagme scientific phrases cause a particular difficulty in perception: their understanding depends on accentuation of separate syntaxemes.


A SHORT digital extensor in the hand was first patient was able to return to work almost immediately and described by Albinus in 1734. As a muscular has ~ m a i n e d symptom-freeanomaly it is now well known to the pure anatomist, especially in the field of comparative anatomy. I t seems, however, that it has been encountered rarely in the course of clinical work, even in specialized hand units. I t is the purpose of this article to describe such a case and to discuss briefly the morphological significance of this anomaly.


A modified compressed block decomposition (CBD) preconditioner combined with the multilevel fast multipole algorithm (MLFMA) is proposed for efficiently solving large dense complex linear systems that arise in electromagnetic problems.The modified preconditioner utilizes some improvements to improve the CBD preconditioner which is constructed from the available sparse near‐field matrix. On the basis of the modified preconditioner, an efficient matrix–vector multiplication is implemented. Accordingly, the modified preconditioner is comparable with the unpreconditioned generalized minimal residual algorithm (GMRES) in terms of the number of iterations and the total solution time. Remarkably, the modified preconditioner provides a reduction close to one order of magnitude in both the number of iterations and the total solution time. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26149


Abstract Background Treatment of patients with Gram negative infections is increasingly difficult due to rising resistance to commonly used agents. Ceftolozane/tazobactam (C/T) is a potent anti-pseudomonal agent with broad Gram-negative coverage, that is indicated for cUTI and cIAI and currently being studied for ventilated nosocomial pneumonia. This study evaluates C/T in a large database of US hospitals to better understand treatment patterns and associated outcomes. Methods This is a retrospective cohort of adult hospitalized patients in the Premier Healthcare Database (PHD) from January 1, 2015 to June 30, 2017, who received ≥2 consecutive days of C/T. The PHD contains demographic, clinical and healthcare resource utilization. Microbiology data are available from a subset of PHD hospitals. Multidrug resistance (MDR) was resistance or intermediate to 1 or more agents in at least 3 classes. Outcomes included hospital length of stay (LOS), 30-day mortality, and readmissions (all cause and infection-related). Results A total of 1490 patients across 253 hospitals met study criteria. Mean age was 59.1 ± 17.5 years, 57% were male, and 65% were Caucasian. The most common comorbidities were chronic pulmonary disease (36%), renal disease (34%), and congestive heart failure (25%). 27% of patients had a prior hospitalization within 30 days. The mean Charlson score was 3 ± 2.4. Over half (55%) of patients were in the ICU, 49% were mechanically ventilated and 15% were on dialysis. Within the 259 patients with microbiology data, the most prevalent pathogen was Pseudomonas aeruginosa (78%). The median (IQR) number of days from admission to first day of C/T was 6 (2–15). Patients received a median (IQR) 7 (4–11) days of C/T. The median (IQR) LOS after the first dose of C/T was 10 (6–18) days. The 30-day mortality rate was 9%. All cause and infection related readmissions were 17 and 9%, respectively. Conclusion Most of C/Ts usage was among critically ill, complex patients treated in the intensive care unit with P. aeruginosa. In spite of the complex nature of these patients, the outcomes among patients treated with C/T were positive and provides needed real-world evidence. Further studies with a comparator group will allow further interpretation. Disclosures L. Puzniak, Merck: Employee and Shareholder, Salary. R. Fu, Merck: Research Contractor, Research grant. J. Gundrum, Merck: Research Contractor, Research grant. T. P. Lodise Jr., Motif BioSciences: Board Member, Consulting fee.


A general account is given of the problem frames approach to the development of software-intensive systems, assuming that the reader is already familiar with its basic ideas. The approach is considered in the light of the long-standing aspiration of software developers to merit a place among practitioners of the established branches of engineering. Some of its principles are examined, and some comments offered on the range of its applicability. A view of the approach is suggested by an important account of engineering in the aeronautical industry: in particular, the problem classes captured by elementary problem frames are likened to those solved in established engineering branches by normal, rather than radical, design. The relative lack of specialisation in software development is identified as an important factor holding back the evolution of normal design practice in some areas.


Abstract Several studies suggest that polyandrous females bias paternity in favor of unrelated males to avoid inbreeding depression. Here we tested whether the migratory locust biases sperm usage toward unrelated males by analyzing the paternity of offspring from females mated with either two siblings, or two nonsiblings, or a sibling and a nonsibling in either order. We found that the eggs of females mated only with siblings had decreased hatching success. When females mated with both a nonsibling and a sibling, egg hatchability was significantly increased. Subsequent paternity analyses found no evidence that females could avoid fertilization by sibling males. Therefore, improvement of the hatchability of eggs sired by siblings suggests that rather than biased fertilization by females toward genetically compatible or superior males, male-induced maternal effects or direct effects of male ejaculates might influence the survival of offspring sired by related males.


The complex-valued differential operator associated with the linear Marguerre equations for a constant thickness, elastically isotropic shallow shell with an arbitrary quadratic midsurface consists of the biharmonic operator minus the imaginary unit i times a constant coefficient second-order differential operator. The fundamental solution of this differential operator is denoted by g(r, θ; κ), where r and θ are polar coordinates and κ is the (dimensionless) Gaussian curvature of the midsurface at the origin. Via a double Fourier transform, a plane wave or Whittaker representation is obtained for g(r, θ; κ). From this is extracted a series representation for g(r, θ; κ) in powers of r2 , with coefficients depending on ln r, θ, and κ. The results are shown to agree with the known special cases for κ = 1, 0, and −1.


The present invention provides an aqueous lubricating coating agent for a treatment of solids, the aqueous lubrication film treatment agent comprising the formula R1-CH (R2) COOH (in the formula, R1, and R2 each independently represent 4 carbon atoms, pour point to a straight or branched alkyl group having 1 2) represented below 0 ℃ branched carboxylic acids and / or salts thereof; and a solid coating component, wherein the total solid content in the aqueous lubrication treatment agent film as a reference to the respective solid content, an amount of mixing a branched carboxylic acid or salt is 0.1 to 50 mass%, the mixing amount of the solid coating component is from 3 to 99.9% by mass. According to the present invention can provide a primarily aqueous lubrication film treatment agent for metal materials, having less foaming, can contain a large amount of lubricating composition, excellent in liquid stability, and can exhibit good lubricity form a coating film. The solid coating component is selected from water-compatible inorganic salt, organic acid salt or a water-compatible water-compatible resin. The treatment may be further mixed lubrication auxiliary component, auxiliary component seizure resistance and the like.


Through the research for AdaBoost face detection algorithm based on Haar-like features,make use of the cascade classifier trained by this algorithm and computer vision library OpenCV to design a face detection system,realize face detection and mark based on static image,camera video and avi video,finish displaying and saving the face region images marked by rectangles real-timely.Besides,achieve the development of software interface by VC++ 6.0.The experiment result shows that the face detection system has features of short develop cycle,rapid detection,real-time and high detection rate,which can be used for the bases of face recognition system and face tracking system.


As early as the 1920s, studies at various elite colleges revealed that public school graduates outperformed private school graduates academically, and more recent research indicates various differences in life patterns between these two groups 25 years after graduation. The two new studies presented here, which look at attendance at college reunions and donations to one's college, extend that earlier work. At a New England college, public school graduates were more likely than the private school graduates to attend their 30th, 35th, and 40th year college reunions. Donations to the school showed that public school graduates were somewhat more likely to make contributions than private school graduates, and graduates of the most socially elite boarding schools were especially unlikely to have made contributions. These findings are discussed in terms of the varying roles that prep schools and colleges play in one's identity.


Abstrcat This paper conducts an analysis of the flow characteristic of Dawen River meandering reach, and analyzes the varying tendency of various hydraulic factors of the meandering reach in flood, moderate flow and dry seasons from three aspects, i.e. variation of horizontal position of the main stream (or variation of dynamic axis of flow), variation of mean velocity in section, mean water depth and longitudinal water surface slope, as well as variation of circulating current and river bends, and analyzes the erosion and collapse processes from the angle of physics.


Introduction TWO shock-wave-reection conŽ gurations, regular re ection (RR) andMach re ection (MR), are possible in steady  ows.1 The RR and the MR consist of two and three shock waves, respectively.Two extreme angles of incidence are associatedwith the oblique re ection of a shock wave. They are the von Neumann A and the detachment AD angles (AD >AN ). For a given  ow Mach number, A is the smallest angle of incidence for which an MR is theoretically possible, and AD is the largest angle of incidence for which an RR is theoretically possible. Consequently, an MR is impossible for A AD . For incident angles in the range A ·A ·A both RR andMR are theoretically possible. Consequently, the RR$MR transition could take place at any angle of incidence A inside that range. The angle of incidence A is determined by the  ow Mach number M and wedge angle μw . Therefore, it is convenient to represent the detachment and von Neumann criteria in the (M; μw ) plane, as is shown in Fig. 1, where μ N w and μ D w , the wedge angles that correspond to the mentioned criteria, are shown for a perfect gas with a speciŽ c heats ratio of ° D 1:4. The curves μ N w .M/ and μ D w .M / divide the plane into three domains: a domain in which only RR is theoreticallypossible, a domain in which only MR is theoretically possible, and a domain, known as the dual-solutiondomain, in which both RR and MR are theoreticallypossible.Note that the curve correspondingto μ N w reaches a maximum value of μ N w;max D 20:92 deg at M D 4:46. At large values of M , the curves corresponding to both μ N w and μ D w approachasymptoticvaluesequal to 17.96and 32.02deg, respectively.


Abstract Funding Acknowledgements Type of funding sources: None. Background Ultra-high-power short-duration (UHPSD) ablation with the novel QDOT™ catheter allows to maintain a target temperature by automatically adjusting flow and power during a 4-second application of 90 Watt. However, the optimal contact-force for a sufficient lesion generation is yet to be determined. Methods This study comprised 41 patients with symptomatic atrial fibrillation undergoing pulmonary vein isolation (PVI) with the QDot catheter using the UHPSD mode with 90 W for 4 seconds. All UHPSD applications for circumferential PVI were analyzed. Suboptimal UHPSD applications were defined as either an impedance drop of ≤5% or a cumulative temperature-limited energy ≤330 W. Results A total of 1904 UHPSD applications (46.4 applications per patient) were performed with an average contact force (aCF) of 12.3±6.4 g with a mean maximum temperature (maxTemp) of 48.4±3.8 °C and a mean impedance drop (ImpDrop) of 10±3.2%. An ImpDrop ≤5% occurred in 67 (3.5%) UHPSD applications which was associated with lower aCF (10.6±7 vs. 12.4±6.4 g; p=0.024) and a lower maxTemp (45.8±3.8 vs. 48.5±3.8 °C; p<0.001) as compared to UHPSD applications with an ImpDrop >5%. A cumulative energy ≤330 W was observed in 39 (2%) UHPSD applications. Interestingly, low cumulative energy UHPSD applications (≤330 W) were characterized by a higher aCF (21±9.6 vs. 12.1±6.2 g; p<0.001). Furthermore, low cumulative energy was observed significantly more often in UHPSD applications with aCF <5.6 g or >21.1 g (10.2% vs 3.6%; p=0.004). Conclusion A low but also a high contact-force (<6 and >21g) are associated with suboptimal UHPSD applications. Thus, UHPSD applications require a '15-gram window' of contact-force to achieve an optimal cumulative energy.


Lower bounds on the size of t -fold blocking sets with respect to hyperplanes or t -intersection sets in AG(n, q) are obtained, some of which are sharp.


Erectile dysfunction (ED) is a fairly urgent problem in modern medicine. The epidemiological situation confirms the need to develop new methods and treatment for ED. Microchemic surgeries in the treatment of ED have more than half a century of history. This manuscript provides an overview of microsurgical treatments for erectile dysfunction.


Background paper for an OECD/EC Workshop on 14 December 2018 within the workshop series "Broadening innovation policy: New insights for regions and cities", Paris.


By analyzing the change rules of the soil moisture content of sunflower in whole growth period using ten years observation data of soil moisture,it showed that there were three low value stages of soil moisture at 30 days after seedling emergence,flower bug stage,and filling stage in the whole growth period in Hetao irrigation area.Therefore,according to the conclusion and the local watering habit,it designed field watering experiment at different time.Using the orthogonal analysis,the results showed that it is suitable for watering oil sunflower at 30 days after seedling emergence,flower bud,flowering stage and the edible sunflower at 30 days after seedling emergence,flower bud,flowering stage,filling stage.On the basis of different actual production condition,it provided different production suggestion for the development of the sunflower.


This study reports a protocol for in vitro regeneration of Salvia x jamensis J. Compton starting from nodal explants of axenic plants and using Murashige and Skoog basal medium containing 0, 3.0, 6.0 or 12.0 μM thidiazuron. The addition of 3.0 μM 6-benzyladenine increases the production of regenerated shoots.


In order to increase quality of flue-cured tobacco for the two major tillage models(Rotation of rice and tobacco and Rotation of maize and tobacco) in Baise tobacco-growing areas,by using the method of quality analysis and statistics,the harmony of chemical components and smoking quality for flue-cured tobacco of C3F and B2F grading were analyzed.The results showed that chemical components of tobacco leaves in two tillage models were better and harmonious,but starch and nicotine contents of tobacco leaves in Rotation of maize and tobacco model were higher than that in Rotation of rice and tobacco.However,potassium(K2O) content of tobacco leaves in Rotation of maize and tobacco model was lower than that in Rotation of rice and tobacco.Starch content in two tillage models were increased significantly in different years.The content of chemical components and harmony of chemical component could be expressed by the scores of chemical components and ratio chemical components by using quality grading assessment,high content of reducing sugar was the main factor leading to low scores of the middle leaves in Rotation of maize and tobacco model.The smoking quality in two tillage models were also good,changed slightly in different years,and the distribution frequency of scores of smoking quality of middle leaves more than 75 in the Rotation of maize and tobacco model was obviously higher than that in Rotation of maize and tobacco,but the smoking quality should be further improved to attain the highest quality of tobacco.


Modern agriculture is an extremely energy intensive process. However high agricultural productivities and subsequently the growth of green revolution has been made possible only by large amount of energy inputs, especially those from fossil fuels. With recent price rise and scarcity of these fuels there has been a trend towards use of alternative energy sources like solar, wind, geothermal etc. However these energy resources have not been able to provide an economically viable solution for agricultural applications.


Objective To explore the mechanism of the neuroprotection of T cells specific to copolymer-1(Cop-1)(TCop-1)in rat glaucoma model.Methods Ten days after 0.2 mg Cop-1 or phosphate buffered solution(PBS)was injected into the rats' hind foot pads,their draining lymph nodes were surgically removed and TCop-1 and TPBS were respectively cultured.The mRNA of γ-IFN and IL-4 were analyzed by means of RT-PCR,through which the subtype of TCop-1 and TPBS can be indicated.Thirty-nine rats with glaucoma were randomly divided into two groups.One group(n=19)were injected with TCop-1 intraperitoneally,the other group(n=20)was injected with TPBS.On 21st day after immunization,the number of retinal ganglion cells(RGCs)was calculated.The amount of brain-derived neurotrophic factor(BDNF)secreted by T cells was measured by using Sandwich ELISA kits.Results The mRNA level of γ-IFN expressed by TCop-1 was higer than that expressed by TPBS.The amount of BDNF secreted by TCop-1 which was restimulated by Cop-1,TCop-1 and TPBS was(3 385.42±836.33)pg/mL,(1 026.24±135.10)pg/mL and(19.87±71.20)pg/mL respectively.The former one was much higher than the latter two(F=175.66,both P0.01,One-way ANOVA and Bonferroi method).Conclusions Th1 specific to Cop-1 might play an important role in protecting RGCs in the rats with glaucoma.TCop-1 can secrete BDNF on the retina,which was at least one of the mechanisms of protection of RGCs.


In order to improve the efficiency of the software intrusion detection system, the author proposes an application based on data mining technology in software intrusion detection and information processing. Apply data mining technology to software intrusion detection; first, analyze and research software intrusion detection technology and data mining technology, including the basic concepts of software intrusion detection, the realization technology of software intrusion detection, the classification of software intrusion detection systems, and the typical software intrusion detection system situation. By detecting and analyzing known intrusion data and using association rules, constructing the inspection system rule base enables the system to learn independently and improve itself and has good scalability, while improving the degree of automation and complete intrusion detection. Experimental results show that under the same test sample, the accuracy of the detection system model designed in this paper is 95.67%, higher than the other three detection systems, and the false alarm rate is lower than other systems, which has certain advantages. It is proved that the system in this paper can help improve the accuracy of software intrusion detection, significantly reduce the false alarm rate and false alarm rate of software intrusion detection, and provide reference for the optimization and improvement of software intrusion detection system and information processing. The system has a certain degree of self-adaptation, which can effectively detect external intrusions.


Zelkova is one of the tree species that is known to have a very high level of growth stress. During sawing, yield decreases as a result of heart crack and distortion of boards owing to growth stress release. Therefore, the study of growth stress in zelkova is considered to be important for its effective utilization. In this study, six erect trees with diameters at breast height ranging from 25 to 45 cm were felled. Surface growth stress of zelkova was measured by the groove method, using resistant strain gauges. Released surface growth stress of trunks at various tree heights, and the residual growth stress distribution over the radial positions from pith to bark were measured. The steaming method was used in an attempt to decrease growth stress, and the effects of different steaming temperatures and duration times on the decrease of growth stress were examined. There was no obvious relationship between surface growth stress and trunk height. The residual growth stress was tensile for the outer part of the tree trunk and compressive for the inner part, yielding a V-shaped stress distribution. Both the surface growth stress and the internal residual stress were reduced by heat treatment. The reduction of longitudinal growth stress increased with increased heating temperature, and with increased heating time. With a 110°C steam heating temperature and 24- to 48-hour exposure time, over 86 percent of the surface growth stress was released. When 85° or 95°C steam heating temperature and 24-hour exposure time was used, only 50 percent of the growth stress was reduced. However, a heating temperature below 100°C may be most suitable for practical applications.


Recent developments in complex networks have paved the way to a series of important biological insights, such as the fact that many of the essential proteins of S. cerevisae corresponds to the so-called hubs of the respective protein-protein interaction networks. Despite the special importance of hubs, other types of nodes such as those corresponding to the network border, as well as the innermost nodes, also deserve special attention. This work reports on how the application of the concept of distance transform to networks showed that a great deal of the innermost nodes correspond to essential proteins, with interesting biological implications.


In 2003, the government of Luiz Ignacio Lula da Silva launched a comprehensive program to stimulate growth and social progress. On the social side, the centerpiece was a sweeping reform of Brazil's social safety net, the Bolsa Familia Program (BFP), which integrated four cash transfer programs into a single program under the umbrella of a new Ministry of Social Development. The transfers are made preferentially to women in each family. The program supports the formation of human capital at the family level by conditioning transfers on behaviors such as children's school attendance, use of health cards, and other social services.


This paper proposes (the number of course selecting/the number of course browsing) to be a new indicator to evaluate the popularity of the course through analyzing the course selection results of Beijing Extracurricular Scientific Practical Activity. The main conclusions of analyzing relevant factors are as follows: 1. The higher star one course gets, the more popular the course is. And word of mouth and teaching experience play important part in course selecting. 2. Some districts like Mentougou and Tongzhou are lack of course resources, resulting in the popularity of these courses are higher than other areas with rich curriculum resources. 3. The courses offered by museums are more popular than those offered by scientific research institutions, which may have something to do with the packaging of the course. 4. The most popular course is about Astronomy, closely followed by Electronics, Information Technology and Physics. And students have less interest in courses related to Geography and Data and Information. 5. The curriculum of Information Technology is a kind of new course comparing to other curricula, which is regarded as STEAM course in a narrow sense. This kind of course is popular which indicates that students accept new type of curriculum well.


OBJECTIVE
To examine whether the Affordable Care Act's Medicaid expansions affected health insurance coverage for individuals in same-sex couples.

DATA SOURCES AND STUDY SETTING
We used data on adults aged 18-64 years in same-sex couples (n=33,512) from the 2008-2018 American Community Survey (ACS).

STUDY DESIGN
To estimate the effect of the impact of the state Medicaid expansions under the Affordable Care Act on health insurance coverage for sexual minorities, we utilize a standard difference-in-differences approach to leverage the variation across geography and time in expanding Medicaid.

DATA COLLECTION
Secondary and publicly available ACS data were obtained from IPUMS at the University of Minnesota.

PRINCIPAL FINDINGS
We find that Medicaid expansion significantly increased health insurance coverage among low-income men and women in same-sex couples by 4.9 (standard error [SE] = 1.75) and 6.5 (SE=1.96) percentage points, respectively. We find increases in the likelihood of having Medicaid and reductions in private health insurance from an employer or privately purchased insurance. Effects on Medicaid take-up are consistently larger for low-income women in same-sex couples as compared to low-income men in same-sex couples.

CONCLUSIONS
We provide the first evidence on the relationship between state Medicaid expansions under the Affordable Care Act (ACA) and health insurance coverage among sexual minority adults, a group that has been understudied in past research. Our results confirm that sexual minority adults benefitted from the ACA's Medicaid expansions with respect to increased health insurance coverage. This article is protected by copyright. All rights reserved.


Summ ary:Instillation itself,as a trad itionalway ofmoral education,doesnt' sufficiently have the qualifications to become a standard in moral evaluation.It stillmakes some sense in today's schoolmoral education,in which edu-cators may face all kinds of confusions.Educators should review it actively,endow it with new meanings of this age,d iscover new ways of instillation and make it shine with new vitality.


Converting small molecules in the atmosphere by using of electrochemical energy devices can generate higher-value products by coupling to renewable energy [1]. Metallic and alloy electrocatalysts play a key role in the energy conversion because they can greatly promote the reaction process [2]. The electrocatalyst performance in terms of activity, durability, and selectivity can be optimized by modifying the structural parameters. Meanwhile, the structures also dynamically change under working conditions, including the hash liquid environment and high overpotential or current density, which affect the catalytic performance accordingly. Real-time study of the structural dynamics of metallic nanostructures is crucial to understanding the degradation mechanism and design advanced catalysts.


Sufficient BS signal level and minimal interferences at SS receiver at "uncertain" areas are possible when using high-altitude panel antennas with narrow radiation pattern and insignificant side lobes in horizontal plane. Panel antenna possesses such properties. It represents horizontal grid made of zigzag antennas.


Objectives: To evaluate the effects of two different e tness programmes (water versus land based) on physical e tness level in patients with chronic low back pain. Design: Randomised controlled study. Subjects: Thirty patients with chronic low back pain randomly followed a land based e tness programme or an aquae tness programme. Methods: Subjects were evaluated with the Euroe t test battery for their physical e tness level. Both groups followed their programmes under supervision of a physiotherapist 3 days/week for 4 weeks. Results: Differences of measurements were not signie cant between the two groups. Signie cant differences were shown in both groups after the therapy programme with regard to aerobic e tness, motor e tness (single leg balance test with eyes open or closed), musculoskeletal e tness, pain reports, Sorensen and Oswestry low back pain disability index scores. No signie cant difference was found between the groups. Conclusion: Supervised aquae tness programmes have effects similar to those based on land e tness programmes on physical e tness level of chronic low back pain patients. summary


(LATEST SUMMARY) National Mass Transportation Assistance Act - =Title I: Increased Mass Transportation Assistance= - Increases, under the Urban Mass Transportation Act, the total amount of obligations which the Secretary of Transportation may incur to finance specified grants and loans to $10,925,000,000. Directs the Secretary to cooperate with the States in formulating long-range plans and programs for the development of multimode urban transportation systems. Sets forth formulas for the apportionment and disbursement of mass transit grants. Empowers the Secretary to incur obligations on behalf of the United States not to exceed $3,975,000,000 to finance such grants. Authorizes to be appropriated for fiscal years 1975 through 1980 sums to liquidate such obligations. Includes as projects eligible for grants under this title: (1) the acquisition, construction, and improvement of facilities and equipment for use, by operation or lease or otherwise, in mass transportation service; and (2) the payment of operating expenses to improve or to continue such service by operation, lease, contract, or otherwise. Limits the percentage of costs of such projects which may be compensated with federal funds. Specifies the procedure for submission and approval of grant applications. Enumerates economic and environmental criteria to be considered in reviewing proposed projects. Stipulates that no project be approved unless the applicant agrees to provide elderly and handicapped persons half-fare transportation during nonpeak hours. Authorizes the Secretary to assist State and local public bodies in financing the establishment and organization of public or quasipublic transit corridor development corporations. Requires the Secretary to study the safety conditions of any facility or equipment financed by this Act and to require correction of any unsafe conditions which he may discover. Withholds assistance, subject to specified exceptions, to any applicant until it has a


University has rich tourism resources such as humanity, social science, environment and service, and has large development potential. Taking China University of Mining and Technology as an example, this paper analyzes the tourism resources and passenger source of university, and advances some strategies for developing the tourism resources of university.


Waterborne intruder detection includes many new challenges not seen in land environments. One area of these challenges is the detection of surface swimmers. Swimmers, whose bodies are partially in air and partially submerged, have significantly reduced target strength (TS) for radar and sonar systems compared to intruders fully in air or fully submerged. This reduced TS results in more frequent missed detections or, if detection threshold is widened, increased nuisance alarms. Depending on sea state, a swimmer is also able to blend in with wave noise, making detection even more difficult. We present a method for improved surface swimmer detection in marine environments by fusing data from several sensor systems in both air and water domains to isolate a swimmer's signature from uncorrelated events. This system, tested in Dec 2011 in St. Petersburg FL, produced data indicating significantly improved detection over using any single system. By widening detection threshold of each sensor's detection algorithm but fusing data of each system together, more potential targets can be processed without the risk of increasing nuisance alarms. This work holds the potential to improve the security of several types of water-dependent assets, like commercial harbors, Navy or Coast Guard bases, and nuclear and other water-cooled power plans, and offshore oil platforms.


The performance of automatic speech recognition systems can be improved by speaker adaptive training (SAT), which adapts an acoustic model to compensate for the mismatch between training and testing conditions. Speaker code learning is one of the useful ways for speaker adaptive training. It learns a set of speaker dependent codes together with speaker independent acoustic model in order to remove speaker variation. Conventionally, speaker dependent codes and speaker independent acoustic model are jointly optimized. However, this could make it difficult to decouple the speaker code from the acoustic model. In this paper, we take the speaker code based SAT as a meta-learning task. The acoustic model is considered as meta-knowledge, while speaker code is considered as task specific knowledge. Experiments on the Switchboard task show that our method can not only learn a good speaker code, but also improve the performance of the acoustic model even without speaker code.


Density functional calculations are implemented to study the interaction of CO, H, and C with a sequential growth of Cu clusters with a special structure (5 ≤ n ≤ 140, where n is the number of atoms). The cohesive energy Ec and average bond length dave of the relaxed Cu clusters increase monotonically as the layer number of the clusters l increases. The adsorption energy Ead values have a sequence of C/Cu < H/Cu < CO/Cu (adsorbate/substrate). The Ead(l) functions are found to be parabola-like for all adsorption systems, with the maximum values at l = 5−6 where dave ≈ 2.56 A, which is approximately equal to the atomic distance of Cu in bulk crystals. The binding strength between the adsorbate and substrate, or −Ead(l), is inversely proportional to their corresponding bond length d.


Applications of fibre-optic cables with conductive support elements for installations on high-voltage line towers are not as common as all-dielectric cable designs. Therefore, the influence of high-voltage lines on such cables has not been studied widely. In this paper, a lumped parameter model in phase coordinates is developed to determine the current and voltage of a conductive element of a fibre-optic cable section installed on a high-voltage line. Methods required to determine the parameters of the mutual induction and electrostatic links for this model are provided. A case study is performed for a figure-8 cable application on a 330 kV line, which indicates that the induced voltage to earth is a significant threat to the cable if the conductive element is insulated from the earth. The demonstrated approach can be used for analysing the influence of a high-voltage line on any elongated conductive object.


This study examines how incentive- and behavior-based variables affect analyst recommendation revisions. We use duration analysis to test analysts' underreaction to information by isolating the effects of incentives and cognitive processing biases on the timing of recommendation revisions. By controlling for favorable (unfavorable) preceding recommendations, we find that analysts delay conveying bad (good) news, which is consistent with the predictions of both the incentives and cognitive dissonance hypotheses (only the cognitive dissonance hypothesis). We also find that analysts delay responses to favorable information for outperformers with lower representative information, suggesting that analysts' underreaction to new favorable information is partially explained by the effect of psychological conservatism. Our results are robust after taking into account analyst affiliations, NASD Rule 2711 and SEC Rule 472, and market conditions.


In this paper I work out a classification of the various types of conversion to philosophy as they appear in ancient Greek biographies, especially in Diogenes Laertius' Lives and tenets of eminent philosophers, to the purpose of making clear that it was a well-established biographical topic. Moreover, the "rites" of initiation to philosophical activity and the different means employed to socially legitimate a philosopher are reviewed from the point of view of ancient biography. This analysis allows us to shed some light on the image ancient Greeks had about their own philosophers as a kind different from other "cultural agents", like poets, as well as from other figures belonging to the collective imagery, like heroes. Palabras clave: biografía griega, conversión, Diógenes Laercio, filósofos griegos, iniciación, tópicos biográficos. recePción: 10 de julio de 2008. acePtación: 31 de octubre de 2008. Modelos2as.indd 67 14/11/08 09:06:45 nova tellvs, 26 ◆2, 2008 69 Modelos de conversión e iniciación a la filosofía: análisis de un tópico biográfico


This paper summarizes the results of a project to develop an electronic repository of "contentrich" lectures, talks, and training activities on the World-Wide Web. The work was carried out from July 1999 to July 2001 by a collaboration consisting of the University of Michigan ATLAS Collaboratory Project, the University of Michigan Media Union, the CERN HR Division, supported by the CERN IT and ETT Divisions and the CERN Academic and Summer Student Programs. In this document, we describe the software application chosen to synchronize the slide presentations to the video recordings, provide technical solutions to the various recording and archival challenges encountered during the project, and propose a set of research and development issues we feel merit further investigation. We also present the concept of a "Lecture Object" and suggest the adoption of standards so that lectures at multiple institutes can be seamlessly shared and incorporated into federated databases world-wide. 1 CERN the European Organization for Nuclear Research, commonly known as the European Laboratory for Particle Physics. C E R N -O PE N -2 00 106 6


A hostile element has been splitting all the time to China. We must keep clear mind, study seriously the feature and method of splitting under the new situation and take effective measure on it so that we can make the plotting go bankrupt.


A CO-modification catalyst of this invention reformed carbon monoxide (CO) and of one or a mixture of platinum (Pt), ruthenium (Ru), iridium (Ir) and rhodium (Rh) as active ingredient and at least one of titanium (Ti) , aluminum (Al), zirconium (Zr), and cerium (Ce) as the carrier for carrying the active ingredient. The CO-modification catalyst can be used in a halogen-resistant CO-modification reactor (15), the CO contained in the gasified gas (12) produced is converted to CO


Pain is a feeling that can be felt in many areas in the body (back, pelvis, chest, abdomen) and is triggered by the nervous system. Pain is most common symptom in conditions of the musculoskeletal system, but also can accompany other conditions like hormonal imbalance, autoimmune, neurological diseases etc. The Traditional Chinese Medicine (TCM) recommends more intensive treatment for pain with acupuncture and herbal medicine, so the blocked Qi can be released and the normal body function can be stimulated. In our study we have done a survey on our patients with questionnaire of 13 questions in our clinic. In the survey participated 41 patients, 6 male and 35 female, of different age groups, with different conditions and with main symptom of pain. All patients have done acupuncture treatment in our clinic in the past year with certain number of treatments. In 63.41% or 26 patients, the overall health condition was improved totally, in 31.71% or 13 patients the condition is partially better and only 4.88% or 2 patients did not have any improvement.


We give deterministic polynomial
time algorithms for two different decision version the modular
inversion hidden number problem
introduced by D. Boneh, S. Halevi and N. A. Howgrave-Graham
in 2001. For example, for one of our algorithms we need to be given about $1/2$ of the
bits of each inversion, while for the computational
version the best known algorithm requires about $2/3$ of the bits
and is probabilistic.


The #MeToo movement promotes awareness of the prevalence of sexual victimization, but it has been criticized for overlooking some survivors. The purpose of this qualitative research is to explore 41 U.S. rape victim advocates' perceptions of the #MeToo movement's inclusion of or impact on survivors who identify as men. Results indicate that advocates perceive that men are not encouraged to disclose their experiences or become involved in the #MeToo movement. This reflects differences in general societal responses to rape survivors based on gender. Advocates' perceptions inform the #MeToo movement's future and possibly the anti-rape movement's future. The movement's efforts to recognize the prevalence of sexual victimization and create change through social media activism may fall short without recognition of the experiences of all survivors.


Autophagy and the ubiquitin proteasome system are the major degradation processes for intracellular components in eukaryotes. Although ubiquitination acts as a signal inducing organelle-targeting autophagy, the interaction between ubiquitination and autophagy in chloroplast turnover has not been addressed. In this study, we found that two chloroplast-associated E3 enzymes, SP1 and PUB4 are dispensable for the induction of both piecemeal autophagy of chloroplast stroma and chlorophagy of damaged chloroplasts. Double mutants of autophagy genes and PUB4 showed synergistic phenotypes relative to single mutants. The double mutants developed accelerated leaf chlorosis linked to the overaccumulation of reactive oxygen species (ROS) during senescence and had reduced seed production. Biochemical detection of ubiquitinated proteins indicated that both autophagy and PUB-associated ubiquitination contributed to protein degradation in the senescing leaves. Furthermore, the double mutants had enhanced susceptibility to carbon or nitrogen starvation relative to single mutants. These results indicate that autophagy and chloroplast-associated E3s cooperate for protein turnover, management of ROS accumulation, and adaptation to starvation. between autophagy and chloroplast-associated E3s In this study, we focused on the requirement of chloroplast-associated E3s for the induction of chloroplast-targeting autophagy in Arabidopsis, and showed that PUB4 and SP1 are dispensable for the induction of both chlorophagy and RCB-mediated autophagy. We further assessed the relationship between PUB-related degradation and autophagy through the phenotypic analysis of single- or double-mutant Arabidopsis lines with mutations affecting the two pathways. During developmental growth or under starvation conditions, single mutants of autophagy genes or pub4 showed distinct phenotypes; conversely, anti-RFP 1G9 clone (MBL), an P4D1 clone (Cytoskelton). Goat anti-Mouse IgG (H+L) Secondary Antibody Goat anti-rabbit IgG (H+L) Secondary Antibody 4X PEG


The Bethe-Salpeter equation for the electromagnetic bound states consisting of afermion and an anti-fermion of spin1/2 is solved in the Ladder approximation in thispaper.The well-known Balmer series is obtained together with the B-S wave functions,which are relativistic covariant,also have correct analytic properties and satisfy thespectra conditions.The results are applied to the processes η~0→γ+(e~+e~-)andη~0→γ+(μ~+μ~-).It is shown that the creation,annihilation and transition processesof such relativistic electromagnetic bound states can be calculated conveniently by usingthe approximate B-S wave functions obtained in this paper.


Investigations of the posterior cerebral arteries (PCA) by transcranial Doppler sonography (TCD) may be less reliable than investigations of the anterior part of the circle of Willis. Nevertheless, a true PCA may be identified by manual compression of the proximal common carotid artery (CCA) during TCD. Therefore, we used CCA compression in clinically indicated TCD studies and assessed retrospectively its risks and prospectively its benefits for PCA evaluations.


approved: ._ M Dr. Machteld C. Mok Quince ( Cydonia oblonga Mill.) is widely used as a dwarfing rootstock for pear {Pyrus communis L.). The disadvantage of this rootstock is its inefficient uptake of Fe, resulting in leaf chlorosis. Application of tissue culture and gene transfer techniques may lead to production of quince clones with improved Fe efficiency. Pear may benefit from traasformation by transfer of genes involved in disease resistance, insect resistance and delay of ripening. The objectives of this research were: 1) to determine the responses of two somaclonal variants, IE-1 and [E-2, to Fe-deficiency stress under greenhouse conditions; and 2) to establish transformation procedures for quince and pear. Two somaclonal variants of quince, lE-l and l'E-2, with tolerance to low-Fe conditions were isolated previously (Dolcet-Sanjuan et at., 1992). These two variants were compared to the original Quince A clone under various conditions in the greenhouse in 1993 and 1994. Whereas Quince A was chlorotic under conditions with high pH (low Fe availability), the variants displayed only little chlorosis. Under those conditions, the chlorophyll and Fe* concentrations in the leaves were significantly higher in the variants than in Quince A. Agrobacterium-mediated gene transfer protocols for quince and pear were devised using leaves as explants. Efforts were directed at the following: improving the regeneration system, selecting the best antibiotic to eliminate Agrobacterium while maintaining a high regeneration frequency, and identifying a suitable selectable marker. Regeneration of Quince A was improved by replacement of agar with 1.6 g/1 gelrite. Regeneration of the pear rootstock RV. 113 was enhanced by cold treatment of the shoot cultures used as explants. The antibiotic timentin, which consists of ticarcillin and a Blactamase inhibitor, was more effective in eliminating Agrobacterium and less inhibitory to regeneration than cefotaxime and carbenicillin. Vectors containing the bar gene (bialaphos resistance) were chosen for transformation experiments since bialaphos caused less damage to the leaf explants than kanamycin at effective concentrations for selection of transformants. GUS (6-glucoronidase activity) assays showed that under the proper conditions, transformed tissues were obtained. Somaclonal Variation, Regeneration and Transformation of Quince {Cydonia oblonga Mill.) and Pear {Pyrus communis L.)


The chemical industry in the US produces a spectrum of materials that find their way into all other industries and into products used in every household. The industry employs about 1.2 million workers. These individuals produce about $140 billion worth of materials ranging from household detergents to pharmaceuticals to polymer-based plastics, fibers, and films. A major segment of the chemical ind~st~ business is an array of about thirty organic chemicals and polymers that are used in applications that touch our lives daily. These chemicals are produced on a huge scale (Table 1 and Table 2) and, collectively, are worth over $60 billion. They are largely commodities produced to meet standard specifications and are sold primarily on the basis of price. Because the scale of production is so large, they are a major factor in the chemical industry's effort to develop marmfacturing technology that meets the environmental expectations of modern society. Catalysis is a major technology used in the manufacture of commodity chemicals. The chemicals produced by catalytic processes are highlighted in Tables 1 and 2. In addition to these organic chemicals and polymers, the two largest scale inorganic chemicals, sulfuric acid (88.6 billion ppy) and ammonia (34.0 billion ppy), are produced by catalytic processes. Catalytic technology is a key to both the economic competitiveness and the environmental acceptability of this major sector of the American economy. Looking to the future, catalysis can also play a signi~c~t role in sustaining this industry by providing the technology to use feedstocks other than petroleum and natural gas. Heterogeneous catalysis in particular will be critical in processes to utilize abundant raw materials like coal and renewable biomass-derived feedstocks.


The article deals with the features of chemical composition, functional, technological properties and biological activity of non-traditional baking raw materials such as amaranth flour, amaranth bran, amaranth oil and chia seeds, which are related to food components containing a significant amount of nutrients and biologically active substances. It is determined that the range of health-improving breads on the Ukrainian market is quite limited; therefore its enrichment with biologically active substances of natural origin will promote the expansion of functional products. Amaranth flour has been found to have high protein (15%) and fiber (4.4%) content compared to wheat one. The fatty acid composition of amaranth oil obtained by vacuum extraction is revealed and 90% of it consists of linoleic, oleic, arachidonic and palmitic acids. In amaranth oil high content of linoleic (41%) and aridecon (16%) acids has found, which are essential and have high biological activity. The peculiarities of influence of amaranth processed products and chia on the formation of wheat bread quality are determinate. The use of processed amaranth products flour and bran does not significantly impact on deterioration of consumer characteristics when they are introduced into the formulation in the amount of 5-10% by weight of wheat flour, and the use of 2-6% amaranth oil in the formulation of wheat bread is inappropriate. The addition of chia as a raw material with high biological value in the amount of 5-15% to the weight of wheat flour positively affects the bulk output of the product and organoleptic properties of the bread. It is proved that the introduction of amaranth flour into the bread formulation improves the mineral composition of the product due to its enrichment with zinc, phosphorus and calcium in 1,52,5 times in comparison with wheat bread without additives. When consuming wheat bread made with the addition of chia seeds, the human body will be additionally provided with calcium, phosphorus, copper, whose quantity increases by 2 and 10 times, respectively. It has been established that the use of wheat bread with the addition of amaranth flour and chia provides food fibers by 54% of daily needs, and also contributes to the improvement of amino acid composition of products due to essential amino acids content growth.


In this paper, Genetic Algorithms is applied to find out the number of PSSs and to optimize their parameters and locations under different operating conditions for Iraqi power network. The problem is formulated as an optimization problem to maximize the minimum damping ratio of the electromechanical modes using different number of PSSs. The robustness and effectiveness of the proposed approach is approved in damping of electromechanical modes of oscillations using Eigenvalues analysis and nonlinear simulation results.


from ditches, etc. Return flows may or may not be unacceptably polluted. Farther downstream pumpage from independent aquifers irrigates additional fields and provides some return flow which may increase downstream quantities but may also increase their salinity. Losses also occur through local evapotranspiration. Return seepage from fields may restore some depletion due to pumping but may also pollute spring waters. Excessive pumping may diminish spring flow across the international border. (Lag time because of storage capacity of the aquifer as well as difficulty of observation may make cause and effect difficult to establish in this case.) In the next downriver country similar occurances are repeated, all of which can have implications for countries farther downstream. At all points along the river changes in the same amounts and quality of water may affect domestic and industrial use. These situations can and do occur in numerous permutations and combinations.


A sedentary lifestyle is a risk factor, significantly increasing the incidence of low back pain (LBP). Higher levels of sedentary lifestyle were witnessed in the workers who spent the greatest amount of their time in sitting positions in the workplace and during free time. The incidence and prevalence of low back pain in sedentary workers were 14-37% and 34-62%. Noticeably, the people with low back pain had higher productivity loss. It specifies more research is required to help individuals with back pain to stay in their work. The main intention of this study briefly reviews the risk factors, associated adaptations, and Interventions in physical therapy for preventing and managing nonspecific low back pain in sedentary workers. To do this review, Information was gathered from the offline library resources and online electronic search databases (Scopus, COCHRANE, PUBMED). The keywords used were low back pain, sedentary workers, risk factors, adaptations, exercise therapy, and sedentary lifestyle. The prognosis and management of low back pain were greatly influenced by several risk factors related to physical, psychological, and occupational factors. During the transition of low back pain from acute to chronic stages, adaptations in various domains like psychological, behavioral, and neuromuscular changes are seen. Exercise therapy itself or in addition to other therapeutic approaches is successful in preventing and treatment of nonspecific low back pain in sedentary workforces. By identifying associated risk factors, and changes adapted by individual patients, Therapists can design proper exercise therapeutic approaches that will provide more effective interventions.


Rgthqtocpeg." ctgc" cpf" rqygt" eqpuworvkqp" ku" c" etkvkecn" eqpegtp" kp" vqfc{Óu" XNUK" system design. Therefore, Silicon-on-insulator wafers are used in semiconductor device applications. Silicon-on-insulator is used for a variety of applications in power switching device, semiconductor memories, high-speed bipolar circuits and microelectro-mechanical system etc. In this thesis work, 90nm bulk-Si MOSFET, partially depleted SOI MOSFET with lightly doped drain implantation and partially depleted SOI MOSFET with lightly doped drain and halo implantation has been simulated using Atlas and Athena module of Silvaco tool. SOI technology is well discussed in terms of its structure, advantages, characteristics, short channel effects and fabrication techniques etc. At 90nm, electrical characteristics of bulk-Si MOSFET, partially depleted SOI MOSFET with lightly doped drain implantation and partially depleted SOI MOSFET with lightly doped drain and halo implantation has been found out. Effect of different parameters such as gate oxide thickness, channel doping and halo implantation on threshold voltage and off current of partially depleted SOI MOSFET has been studied. Further, a capacitorless 1T DRAM cell has been designed using 90nm partially depleted SOI MOSFET with lightly doped drain implantation. Also, working of capacitorless 1T DRAM using partially depleted SOI MOSFET as access transistor has been shown. Leakage current in partially depleted SOI with lightly doped drain implantation has been reduced by using process technique, called halo implantation. The leakage current in partially depleted SOI MOSFET with lightly doped drain and halo implantation has been reduced by about 90% as compared to partially depleted SOI MOSFET with lightly doped drain implantation.


In order to monitor the crack propagation of the structure in the working state for a long time, an operation modal analysis method based on pseudo-successive data is proposed. The vibration response signals of the cantilever beam under white noise excitation are collected and the modal parameters are extracted by the time-frequency operation modal analysis method based on the complex Morlet wavelet. In comparison with the experimental modal analysis results of hammering method, it is revealed that the error of the time-frequency operation modal analysis method is less than 10 %. By setting cracks of different lengths on the cantilever beam, the vibration response signals are extracted, and the modal parameters are extracted by the operation modal analysis method separately. By comparing those modal parameters above, it is found that the natural frequencies of the second, the fourth and the sixth orders decrease with the increase of the crack depth, and the changes of natural frequencies show the monotonicity. So, it can be used as an index for quantitative identification of crack damage. The pseudo continuous data monitoring signals of crack propagation can be constructed by means of "first discrete, then continuous". The modal parameters changes of the whole crack propagation can be observed in one time plane by means of the operation modal analysis method. Therefore, the effective monitoring and diagnosis of the structure can be completed in case of excessive data of long-time vibration monitoring signals.


The rheology of a 58.6 percent procaine penicillin G suspension was followed for a 24-month period. Samples stored as recommended (5°) were unchanged after 2 years. Samples stored at 26 and 37° increased in viscosity, yield value, and thixotropy with time.


The Question As a Professional Development School (Hohnes Group, 1986: 1990), teachers at Alpha Senior High School have been intensively involved in preservice education efforts for over a decade. Alpha Senior High School faculty have served in a number of teacher educator capacities including teacher education program development, teaching and co-teaching various methods courses at the university, and serving as university field instructors, as well as acting as mentor teachers for preservice teachers. The last role, serving as mentor teachers to preservice teachers during their undergraduate preparation and internship, has clearly become a more complex activity at Alpha Senior High School than merely handing over classrooms of students to preservice teachers. Mentor teachers frequently "talk out" their thinking and decision making for their interns, co-plan and co-teach with interns, observe and critique intern planning and teaching, and participate as equal partners with the university field instructor in evaluation of the intern's progress. At Alpha Senior High School, teachers have begun to think more explicitly as teacher educators. They have begun to assume many of the roles and responsibilities typically seen as the province of university representatives especially in the arena of intern evaluation. Several years ago, a mentor teacher and university field instructor were working with an intern who was experiencing serious problems in achieving program standards necessary to enable recommendation for certification. Over the course of many lengthy consultations about how best to support the intern while maintaining adherence to the program standards, it became apparent that this was not the first time the mentor teacher had to deal with the possibility that the preservice teacher with whom she was working might not successfully complete the program. This realization spawned many conversations between the mentor teacher and university field instructor concerning the effects preservice teacher struggles and failure had on the mentor teacher. The activity of working with a preservice teacher during an internship is a complex and intensive one. It represents a huge investment on the part of mentor teachers. Given this investment, it is not surprising that the effects of preservice teacher failure on the mentor teacher would be complex. We began to question how preservice teacher failure might affect the mentor teacher's conceptualization of herself as a teacher educator. How might it affect the mentor teacher's beliefs about what it means to help someone learn to teach? In what ways might it affect her conceptualization of herself as a teacher? We knew that we were not the only ones chewing on these questions. Several other teachers at Alpha Senior High School had also experienced preservice teacher struggles and failures in some form over their years as mentor teachers. As we began to talk about our experiences and share our questions, it became clear that while we certainly believed that we were not alone in having to struggle with the effects of preservice teacher struggles and failure, little had been written on the subject. An ERIC search revealed limited citations for articles concerning preservice teacher failure, and none on the effects of preservice teacher struggles or failure on the mentor teachers. Of the few citations available, most focused primarily on trying to identify the causes or characterizations of preservice teacher failure (Butler, 1998; Harwood, Collins, & Sudzina, 2000; Mason, 1999; Riner & Jones, 1993: Schmidt & Knowles, 1995: Sudzina & Knowles, 1993). We were unable to locate any research or anecdotal material on the implications preservice teachers' struggles and failures might have for mentor teachers. This article, therefore, represents an opportunity not only to share our stories and what we've learned from our experiences, but to also place this issue on the table for wider discussion and investigation. …


Assessing the concentration of potentially harmful heavy metals in the soil of greenhouses is important in order to evaluate the potential risks to humans. These risks may be higher in soils to which fertilizers have been applied over many years. To investigate this risk, the concentrations of copper (Cu), chromium (Cr), cadmium (Cd), lead (Pb) and zinc (Zn) were measured by a flame atomic absorption spectrophotometer in greenhouse soils collected in Shenyang, Liaoning Province, China, a region well-known for greenhouse cultivation. The environmental quality of greenhouse soil was assessed using the single pollution index method and the Nemerow comprehensive index method based on the environmental standard for greenhouse vegetable production in China (HJ333-2006). The results indicated that the heavy metals accumulated to greater levels in the greenhouse topsoils with increasing cultivation periods. The highest concentration of Cu was observed in greenhouse topsoils planted for 15 years. The distribution of heavy metals in soil profiles (0~20cm, 20~40cm, 40~60cm, 60~80cm, 80~100cm) displayed a wide range of variation. Cr, Pb, and Zn tended to accumulate in the greenhouse topsoil (0~20cm). The maximum value of Cu and Cd were observed at a depth of 80~100cm and 40~60cm in the greenhouse cultivated for 20 years, respectively. As the cultivation periods prolonged, Cu was subject to downward movement to the lower soil horizons and Cd began to accumulate below the topsoil due to the strong migration ability. Using the the single pollution index and the Nemerow comprehensive index of heavy metals, the soil quality in greenhouse topsoils were generally found to be polluted by Cd. This suggests that care should be taken with fertilizers in greenhouse cultivation. This study shows that heavy metals may accumulate in the greenhouse soils with prolonged cultivation periods.


Virtual schooling offers a wealth of tools and services that give users information and education. The opinions of students about this schooling are diverse. Each of them is passionate about a certain form of education, and their studies are overshadowed. The purpose of this research is to compare the attitudes of BA and MA students in virtual education.  A total of 50 students in Tehran participated in this research. The study's statistical population is comprised of all Tehran students. The field data was gathered using the Attitude to Virtual Education Questionnaire. The analysis was conducted using SPSS software and included descriptive statistics (mean and standard deviation) as well as inferential statistics (independent t-test). The findings revealed that there was a considerable difference in performance between BA and MA students. Graduate students have a more favorable view toward virtual education than undergraduate students, although the difference is minor. Based on the outcomes of this research, virtual education seems to be a viable alternative to face-to-face learning.
Keywords: Attitude, e-learning ; Virtual Education.


We estimate black hole masses (M$_{\rm BH}$) for 14 gravitationally lensed quasars using the Balmer lines along with estimates based on MgII and CIV emission lines for four and two of them, respectively. We compare with results obtained for other lensed quasars. We use spectroscopic data from the Large Binocular Telescope (LBT), Magellan and the Very Large Telescope (VLT) to measure the FWHM of the broad emission lines. Combined with the bolometric luminosity measured from the spectra energy distribution, we estimate M$_{\rm BH}$ including uncertainties from microlensing and variability. We obtain MBH using the single-epoch method from the H$\alpha$ and/or H$\beta$ broad emission lines for 14 lensed quasars, including the first estimates for QJ0158-4325, HE0512-3329 and WFI2026-4536. The masses are typical of non-lensed quasars of similar luminosity, and the implied Eddington ratios are typical. We have increased the sample of lenses with estimates of MBH by 60%.


The pancreaticoduodenectomy (hereinafter referred to as PD) is difficult and complicated to operate, so it is one of the most challenging operations in general surgery. Moreover, the incidence of its postoperative complications is high, and pancreatic fistula is the most common and most serious complication which often can induce other complications, hence, it is deemed as the most common complication to cause the death of PD patients. In our opinion, the pancreatic fistula should be clearly diagnosed and the related risk factors for the occurrence of pancreatic fistula should be studied so as to reduce occurrence of pancreatic fistula and further take effective prevention measures, which is of important significance to improve the curative effect of pancreaticoduodenectomy. In this paper, the literature on pancreatic fistula after pancreaticoduodenectomy is reviewed, and it is summarized as follows.


The invention concerns a method (110) for operating an energy accumulator (104) for a photovoltaic system (100) which is subject to Einspeisebegrenzung (202) for supplying power to a public power grid (114), said method (1100), a step (1102) comprises of reading, a step (1104) of determining, and a step (1106) of providing. In the step (1102) of reading at least one characteristic value (t In the step (1104) of detecting a charging start time (t In the step (1106) of providing a load signal for the energy storage (104) to the determined charging start time point (t


We investigated the activation of c‐fos transcription following UV irradiation, a 'stress' stimulus. In both HeLa TK‐ and NIH 3T3 cells the Serum Response Element is required for efficient UV‐induced c‐fos transcription, and in HeLa TK‐ cells the Ternary Complex Factor (TCF) binding site contributes substantially to activation. Consistent with this, UV irradiation activates LexA‐TCF fusion proteins more strongly in HeLa TK‐ than in NIH 3T3 cells. The TCF C‐termini of the TCFs are substrates for UV‐induced MAP kinases: both the Elk‐1 and SAP‐1a C‐termini are efficiently phosphorylated by the p38 MAPK, but only the Elk‐1 C‐terminus is a good substrate for the SAPK/JNKs. The specificity and activation kinetics of TCF C‐terminal kinases, and the susceptibility of transcriptional activation by LexA‐TCF fusion proteins to specific inhibitors of different MAPK pathways, show that both the ERK and p38 MAPK pathways contribute to TCF activation in response to UV irradiation. Activity of both these pathways is also required for the response of the c‐fos gene itself to UV stimulation.


The hybrid optical pumping spin exchange relaxation free (HOPSERF) atomic co-magnetometers make ultrahigh sensitivity measurement of inertia achievable. The wall relaxation rate has a big effect on the polarization and fundamental sensitivity for the co-magnetometer, but it is often neglected in the experiments. However, there is almost no work about the systematic analysis of the influence factors on the polarization and the fundamental sensitivity of the HOPSERF co-magnetometers. Here, we systematically study the polarization and the fundamental sensitivity of 39K-85Rb-21Ne and 133Cs-85Rb-21Ne HOPSERF co-magnetometers with low polarization limit and the wall relaxation rate. The 21Ne number density, the power density and wavelength of pump beam will affect the polarization greatly by affecting the pumping rate of pump beam. We obtain a general formula on the fundamental sensitivity of the HOPSERF co-magnetometers due to shot-noise and the fundamental sensitivity changes with multiple systemic parameters, where the suitable number density of buffer gas and quench gas make the fundamental sensitivity highest. The fundamental sensitivity $7.5355\times10^{-11}$ $\rm rad/s/Hz^{1/2}$ of 133Cs-85Rb-21Ne co-magnetometer is higher than the ultimate theoretical sensitivity $2\times10^{-10}$ $\rm rad/s/Hz^{1/2}$ of K-21Ne co-magnetometer.


Micro-nano structured TiO2 films were prepared by hydrothermally seed layer-induced synthesis. The results showed that the films were composed of TiO2 platelets in size of 2μm~10μm. The maximum distance between platelets was ~4 μm. There were TiO2 nanodots (seed layer) in size of ~100nm between TiO2 platelets. This structured film was proven to be anatase and more anatase was detected along with hydrothermal synthesis. Water contact angle varied from 103° to 149° along with hydrothermal synthesis and all films showed super-hydrophilicity after UV illumination. These micro-nano structured films obtained in this study could potentially applied in many biomedical applications, e.g., osseointegration film and cell sheet technology, owing to its excellent biocompatibility and UV switchable super-hydrophilicity.


Based on the analysis of planting states of Jujube in Cangzhou, the existed problems were introduced in the aspects of aim, agricultural materials, industrial scale and management of science and technology, and the relevant development strategies about the policy, organization form, production, technology and management were also suggested.


analysis was used for 10 subjects to evaluate the accuracy of a multi-atlas approach. The five best atlas matches were automatically found for each test subject and the VOIs from each were deformed to the test subject. The five VOIs were combined using majority vote into a single auto liver VOI. The Dice Similarity Coefficient (DSC) was calculated between the auto VOI and the manual VOI for each subject. Times to correct the auto VOIs into final VOIs were recorded and compared to previously determined average manual segmentation times. Methods & Materials Forty subjects with CT scans and pre-defined liver VOIs were made into an atlas library. A leave-one-out


This paper proposes a novel compliant flexure-based microgripper with a second order amplifier including Scott-Russell magnification mechanism (SRMM) and lever amplifier. Both the dynamic model of the system and the Bouc-Wen hysteresis model are established and identified through using least square optimization method. For eliminating the hysteresis phenomenon of the actuator, compensation control method based on inverse dynamic model is proposed. A novel control strategy based on adaptive backstepping sliding model control (ABSMC) with compensator is presented to control the nonlinear system. Simulation results demonstrate that the performance of proposed control strategy is superior to conventional backstepping sliding mode control (CBSMC).Copyright © 2015 by ASME


Data-driven fault diagnosis utilizing deep learning algorithms is currently a topic of great interest. Without proper training, data-driven models usually fail to generalize on operating conditions different from the ones used in the training set. The majority of domain adaptation research for machinery fault diagnosis focuses on the transfer between limited working conditions for the same machine. In real-life applications, machines operate under a wide range of operating conditions and the data are mostly available for healthy conditions with seldom failures. Hence, models generated from controlled experiments do not usually generalize well under substantial domain shifts. To address this issue, this paper proposes a semi-unsupervised domain adaptation approach for cross-machine fault diagnosis which integrates model optimization and Generative Adversarial Networks (GANs) to bridge the gap between source and target domains. Experiments of transferring between two bearing data sets show that the proposed method is able to effectively train an optimized model that generalizes on both the source and target domains, and train a generator that learns the source domain probability distribution to substitute for larger domain shifts.


Blue rubber bleb nevus syndrome (BRBNS) is characterized by typical bluish, soft, and compressible lesions with rubber-like consistency present since birth. In this syndrome, venous malformation (VM) is always present since birth and is commonly found in the cheek, tongue, lip and jaw, and sometimes may be present in deep tissue, bone, or muscle. A vascular malformation is known to grow in size throughout the life of an individual with sudden enlargement in size during puberty and pregnancy due to hormonal changes. We report the successful management of a case of congenital VM of the lip and mandible posted for emergency cesarean section under spinal anesthesia.


Studies of chromosomal rearrangements and fusion transcripts have elucidated mechanisms of tumorigenesis and led to targeted cancer therapies. This study was aimed at identifying novel fusion transcripts in esophageal adenocarcinoma (EAC).


Multi-view graph clustering, which seeks a partition of the graph with multiple views that often provide more comprehensive yet complex information, has received considerable attention in recent years. Although some efforts have been made for multi-view graph clustering and achieve decent performances, most of them employ shallow model to deal with the complex relation within multi-view graph, which may seriously restrict the capacity for modeling multi-view graph information. In this paper, we make the first attempt to employ deep learning technique for attributed multi-view graph clustering, and propose a novel task-guided One2Multi graph autoencoder clustering framework. The One2Multi graph autoencoder is able to learn node embeddings by employing one informative graph view and content data to reconstruct multiple graph views. Hence, the shared feature representation of multiple graphs can be well captured. Furthermore, a self-training clustering objective is proposed to iteratively improve the clustering results. By integrating the self-training and autoencoder's reconstruction into a unified framework, our model can jointly optimize the cluster label assignments and embeddings suitable for graph clustering. Experiments on real-world attributed multi-view graph datasets well validate the effectiveness of our model.


This design aims to propose methods that architecture can generate complex place of human and environment and keep its existence in the mobile-oriented age. Daehangno cultural district, the site of this thesis, is losing its cultural role in these days. Focusing on the flow of non-material elements such as information, I proposed the system of conversion for the relation between Cultural program of Daehangno and visitors as the method that reactivates cultural factors. Hub system (proposed above) has been used as the system for the effective access or transfer to the Internet structure formation as well as transport system, and I worked to find the constructional constituent state for the realization of this system. A research focused on how to access or transfer was performed and some principles more advantageous were selected and arranged. It is open construction of the structure expose by realization results. The constructional method was set as design concept for making open structure. A Building formed following the principle above is not a vertical plane form of the present and it constitutes a territory by people's fluidity. So it comes to have flexible boundary and be given a form of open structure containing vertical, horizontal continuity concurrently. This research doesn't limit areas need Hub construction within the cultural district of Dahangno. These methods can be applied to rescue and reactivate cultural role of construction lost by the undergoing change of social environment in the city.