We are pleased to present the proceedings of the XperienceWeb 2012 workshop, which was held as part of the World Wide Web 2012 Conference in Lyon, April 2012. This workshop has evolved out of the webCBR workshop series, which primarily promotes the application of case-based reasoning (CBR) to experiential content on the web. Clearly such content is on the increase with advances in web technology resulting in vast amounts of user generated web content in the form of blogs, tweets, forums and opinion sites. Whilst such content can be treated as documents we take the view that they are more appropriately viewed as a rich source of untapped experience data, a valuable asset that can be used to generate Web experience bases through CBR technology. The key idea in CBR involves the reuse of similar experiences to resolve new problems. Such reasoning is relevant to the web because increasingly people search and browse other people's experiences on travel, medicine, retail, entertainment, etc., for their informational and problem solving needs. Typically this vast repository of untapped knowledge and experience exists in unstructured text and multimedia forms. These rich informational snippets generally describe a particular problem situation often combined with a reflective narrative consisting of decisions made, lessons learnt and opinions expressed. Such content forms a rich source of untapped experience data - an integral resource for problem solving with CBR. For example, if one wants to identify web content that helps them to achieve a particular task (say software configuration and installation), then it is likely that there will be many related user posts describing experiences on similar tasks and crucially include suitable solutions to address such a task. We therefore envisage a new form of user need, one that possibly embodies knowledge, meaning and understanding as opposed to chunks of keywords for queries and snippets. Addressing this need calls for novel extraction, representation, retrieval and assembly strategies from existing experiential content on the web. The focus of this workshop was to provide a forum for the discussion of trends, research issues and practical experiences on the role of tools and technologies in reasoning with web-related experiential content. Six papers were accepted for the workshop, covering a wide range of web experience data. Adekyanju et al. present an approach for combining knowledge from web data and search logs for query recommendation. Kato et al. propose a method for extracting onomatopoeia from restaurant reviews and using these in a restaurant recommender. Schumacher et al. compare two methods for extracting procedural or 'how-to' knowledge from the web and Zarka et al. look at the potential for experiential approaches to recommendation to enable a more context-aware method of generating useful video recommendations, particularly in relation to temporal context. Two of the accepted papers are position papers. The question of how user-generated content can be mined successfully for solutions to specific problems is discussed by Sauer & Roth-Berghofer while Gorg et al. consider the problem of constructing and managing personal workflows over a social network.


Through comparing the provincial universities at the same period,the article analyzes the current situation of teaching staff,states the countermeasures to enhance the construction of teaching staff.


This paper has examined the connection between government ownership and cost of financing in Indonesia, Singapore, and Malaysia. Other than that, this paper analyzes whether or not political connection influence the access to external finance through government ownership. Estimates established are tested with balanced panel data during 2009-2013. The fixed-effects model also utilized in order to adjust firm-specific and time-specific intercept effects. Findings from the regression support hypothesis that the government ownership is negatively affect the cost of external finance. Further results bolster another hypothesis that government ownership is positively associated with access to external finance. These findings provide insight as a decision making base for public investors whether or not to invest in companies with higher government ownership.


................................................................................................................................. 6 Introduction ............................................................................................................................ 6 Materials and Methods ........................................................................................................... 7 Results & Discussion .............................................................................................................. 9 Conclusion ............................................................................................................................22 CHAPTER II: Evaluation of the Transparency and Biocompatibility of Al2O3 Doped DiamondLike Carbon Thin Films .............................................................................................................23 Abstract .................................................................................................................................24................................................................................................................................24 Introduction ...........................................................................................................................24 Materials and Methods ..........................................................................................................25 Results and Discussion .........................................................................................................27 Conclusion ............................................................................................................................39 CONCLUSION ..........................................................................................................................40 REFERENCES .........................................................................................................................41 APPENDIX ................................................................................................................................45 VITA ..........................................................................................................................................47


Tylenchulus semipenetrans nematodes affect citrus crops and may develop resistance to commercially available nematicides. In this sense, two series of 1,3,4-oxa- and thiadiazole compounds have been recently synthesised and tested as nematicides against T. semipenetrans, demonstrating promising results. We report herein a molecular modelling study that combines these two series of congeneric compounds to form a single and enhanced data set. The chemical structures of these compounds were correlated with the respective nematicidal activities (pLC50) using multivariate image analysis (MIA) descriptors in quantitative structure-activity relationship (QSAR) analysis. The partial least squares (PLS) regression yielded reliable and predictive models (, , and ). Therefore, novel 1,3,4-oxa- and thiadiazole derivatives were proposed and a few of them exhibited predicted nematicidal performance better than those of the parent compounds.


We first suggest a bi-parametric Lorenz curve, which is a simple rational function, and then analyze the curvature structure of the function. We then build a series of single-parameter Lorenz curves with varied curvatures, which are special cases of the rational function. A hybrid method is then introduced for creating efficient functional models for the Lorenz curve from the single-parameter functional forms. A set of models is created and first tested using income distribution data from the United States. The test show that the models perform well. As an application, one of the models is then used to study world income inequality between 1950 and 2006. We find that the aggregate Gini coefficient is higher than 0.55 for more than half of the period. The index stabilized at an average level larger than 0.59 after 1983. Decomposition calculations show that the within contribution to the Gini is less than 0.10 for most of the years. Therefore, the large aggregate Gini is attributable to income difference across countries. Our estimates suggest that it may not be possible to rank world income distribution in terms of aggregate Lorenz curves.


In this time, a few associations are putting away their information on distributed storage so as to meet the prerequisites of effective activity like soundness, versatility, and accessibility of administrations. Information replication benefits in distributed storage frameworks are there to improve execution. In this unique situation, the prerequisites for guaranteeing information consistency have turned out to be progressively significant. In this paper, we have proposed a virtual server solution for refreshing replication, effectively settling assets, distinguishing and avoiding gridlocks at the server sides. In this original study, we have demonstrated that the proposed arrangement yields the outcomes for the construction which guarantees information consistency in regard to expenses and idleness. we utilize the Open Stack apparatus, which joins a proposed calculation on Adjusting Consistency Accessibility in Physical Machine for keeping up information consistency in Distributed storage Frameworks.


The impact of acute one time injection (45 minutes after) of Pb acetate (100 mg/kg. i.m) in the speed of falling in shallow hypothermy (upto 35 0C) and spontaneous warm up until euthermy (41.5 – 420 C), was followed in Hybro Brown chicken (N=16, six weeks old).


This paper presents a new realization of a first-order mixed-mode (Voltage input Current output) (MM) all-pass filter (APF) using the recently proposed modern active building block (ABB), namely the Voltage Differencing Voltage Transconductance Amplifier (VDVTA). The MM APF is made using minimum number of components, namely a single VDVTA and one grounded capacitor. The circuit does not use any external resistors and offers the advantages of current-tunable pole frequency, low input impedance and high output impedance. PSPICE simulation results are included to verify the workability of the circuit.


Breast cancer has been chosen as the leading cause of cancer-related death in women. Biopsy is still the most accurate way to detect cancer cells. However, this is time-consuming and requires a relatively expensive cost and requires a pathologist. Advances in machine learning make it possible to detect and diagnose breast cancer using histopathological images that are the result of a biopsy. BreakHis dataset is a dataset that provides histopathological images. This study proposes the use of this dataset for cancer classification based on histopathological images using EfficientNet-B0 on the Convolutional Neural Network (CNN). The purpose of this study is to improve the performance of previous studies and to determine the effect of augmentation and dropout layers on the proposed model. This study also applies cross-validation to get more accurate results. The results showed that the EfficientNet-B0 model combined with augmentation and dropout layers with the application of kfold cross validation k=7 was able to improve performance in previous studies with an accuracy of 98.90%. The application of data augmentation and dropout layer techniques has also been shown to increase accuracy and reduce overfitting of the proposed model.


Let $(X_i)_{i \geq 1}$ and $(Y_i)_{i\geq1}$ be two independent sequences of independent identically distributed random variables taking their values in a common finite alphabet and having the same law. Let $LC_n$ be the length of the longest common subsequences of the two random words $X_1\cdots X_n$ and $Y_1\cdots Y_n$. Under a lower bound assumption on the order of its variance, $LC_n$ is shown to satisfy a central limit theorem. This is in contrast to the limiting distribution of the length of the longest common subsequences in two independent uniform random permutations of $\{1, \dots, n\}$, which is shown to be the Tracy-Widom distribution.


Aiming at the existing defects of evidence dempster-shafer theory (DST) in dealing with high conflict evidence, we proposed a new method to improve DST. By introducing concept of fuzzy consistent matrix, calculate the weights of factors, and put different sources of evidence into distinguish, and finally cast more than one vote to prevent the phenomenon, the average convergence of evidence. What's more, the improved DST new method is applied to the rolling bearing fault diagnosis of CNC machine workbench .The test results show that the improved new synthetic formula increases the accuracy of fault diagnosis Ball, the conflict of evidence synthesis results better, to achieve better results.


Argumentation is a major topic in the study of artificial intelligence. In particular, the problem of solving certain reasoning tasks of Dung's abstract argumentation frameworks is central to many advanced argumentation systems. The fact that problems to be solved are mostly intractable requires efficient algorithms and solvers, that are to be evaluated on meaningful benchmarks. In this report, we introduce the Second International Competition on Computational Models of Argumentation (ICCMA'17), which is jointly organized by TU Dresden (Germany), TU Wien (Austria), and the University of Genoa (Italy), in affiliation with the 2017 International Workshop on Theory and Applications of Formal Argumentation (TAFA'17).


The declining costs of commodity disk drives is rapidly changing the economics of deploying large amounts of on-line storage. Conventional mass storage systems typically use high performance RAID clusters as a disk cache, often with a file system interface. The disk cache is backed by tape libraries which serve as the final repository for data. In mass storage systems where performance is an issue tape may serve only as a deep archive for disaster recovery purposes. In this case all data is stored on the disk farm. If a high availability system is required, the data is often duplicated on a separate system, with a fail-over mechanism controlling access. This work explores an alternative design using massive arrays of idle disks, or MAID. We argue that this storage organization provides storage densities matching or exceeding those of tape libraries with performance similar to disk arrays. Moreover, we show that through a combination of effective power management of individual drives and the use of cache or migration, this performance can be achieved using a very small power envelope. We examine the issues critical to the performance, energy consumption and practicality of several classes of MAID systems. The potential of MAID to save energy costs with a relatively small performance penalty is demonstrated in a comparison with a conventional RAID 0 storage array.


Drastic reduction of greenhouse gases emissions depends, among other factors, on a quick and efficient integration of renewable sources in the energy generation pool. In this context, hydropower nowadays represents the biggest share of the world renewable energy generation. However, in the case of European Union, many hydropower plants are about to reach their end-of-life stage and environmental regulations on the recovery of natural water flows require these plants to be dismantled. In the controversial scenario where the need to recover natural waterflows and the loss of a key source of green energy clash with each other, the objective of this work is to provide an exhaustive review of the different auxiliary services that hydropower plants can provide in the current and especially future decarbonized electricity paradigm. To this end, services such as participation in secondary and tertiary regulation markets, power purchase agreements, local energy communities, reduction of curtailments, renewable energy storage or contribution to physical inertia to the grid are analyzed and final conclusions are drawn.


1. TKS Bochum: Hot rolled stainless steel Specification and installation of the surface inspection system The delivery and performance specifications for the installation of an automatic surface inspection system for the topside of hot strip were defined for the TKS hot strip mill at Bochum. Necessary requirements of the IT infrastructure have been discussed and specified. The measuring cabinet for the surface inspection system was planned, installed in front of the down-coiler and the surface inspection was put into operation. The system is working continuously with a pre-configured classifier since October 2000. Problems with pseudo defects caused by water drops on the strip could remarkably be reduced. The short-time archiving-system was extended by the factor 10 to prolong the archiving-time to about ten days. This was necessary, because the feed back from the further processing lines (pickling- and cold rolling) is essential for definite defect identification and adaptation of the defect search-algorithm. Pretrained classifier, status of the classification and use A pretrained classifier was used, which was developed on the basis of defect images of different hot rolling production lines. This new tool made it possible to accelerate the detection adjustment and the classification training. The pretrained classifier was further developed with respect to a steady improvement of the classification- and assignment-rate. At the end of the first semester of 2002 the acceptance conditions for carbon steel grades were reached for the parsytec system on basis of 20 reference coils with respect to the aimed classification rate of 85%. The detection and classification of periodic defects like roll marks is successfully used by the hot strip mill. Periodic defects are displayed at the line and used operationally. So the rolling stand causing the indentations can be determined after a short production period and waste production can be reduced. A comparison of automatic and visual inspection results was executed on a hot strip recoiling line. It was demonstrated, that almost all defects had been detected by the SIS Hot Stainless Strip. Twenty reference coils were selected in the comparison of automatic and visual inspection results on the hot strip recoiling line. The defect pictures of these coils are completely stored electronically. These coils contain almost all relevant defect types and will be used in future as reference strips to evaluate and optimise the classification-progress. At the end of the project the mean classification-rate reached about 87%, the mean defect assignment rate about 91 %. Development of a material-type dependent classifier for splinter type defects A special splinter-type defect, which occurs during rolling of stabilised and unstabilised ferritic steel grades was studied. This surface defect consists of rolled in matter (rolled in splinter) in the edge regions. A separate defect class specially assigned to the steel grade "ferrite" was created. By the combination of an additional material type classifier and the visual classifier the classification rate for the splinter-type defect could be increased substantially.


We developed the microwell device for measurement of membrane transport of single adherent cells. As the cells in a population (e.g., tumor) is inevitably heterogeneous, a technique to measure the transport activities at a single-cell level is needed. When adherent cells were cultured on the microwells with ~10 μm diameter, they spread over the opening to form the closed picoliter space. Thus, molecules exported from cells accumulate in such a space and be detected by fluorescence imaging. In this report, we show that, by employing horizontal microwell design, materials exported from the cell membrane can be visualized without overlapping with the cell, increasing the S/N ratio of the fluorescence signal. Efflux of the cancer drug transported by the multidrug resistance protein was detected.


0 522 296 A2 1/1993 (EP) . (75) Inventors: Quanyuan Shang, Saratoga; Sheng O 697. 467 A1 2/1996 (EP) . Sun, San Jose; Kam S. Law, Union O 702 O98A1 3/1996 (EP) . City; Emanuel Beer, San Jose, all of O 843 347 ?2 5/1998 (EP) . CA (US) 4-236766 8/1992 (JP). 8-199400 8/1996 (JP). (73) Assignee: Applied Komatsu Technology, Inc., OTHER PUBLICATIONS Tokyo (JP) O'Hanlon, John F., "Advances in vacuum contamination (*) Notice: Under 35 U.S.C. 154(b), the term of this control for electronic materials processing", Journal of patent shall be extended for 0 days. Vacuum Science & Technology, Section A 5 (1987), Jul/ Aug. No. 4, Part III, pp 2067—2072. (21) Appl. No.: 09/115,111 * ??? cited by examiner (22) Filed: Jul. 13, 1998 ? Primary Examiner Jeffrie R. Lund (51) Int. Cl.? ..... C23C 16/00 (74) Attorney, Agent, or Firm-Fish & Richardson, P.C.; (52) U.S. Cl. ..... 118/723 ME; 118/723 IR; McGregor & Adler, LLP 118/723 ER; 118/715 (58) Field of Search ............................. 118,715,723 ME, (57) ABSTRACT 118/723 GR, 723 IR, 723 I A Substrate processing System includes a processing cham (56) References Cited ber a plasma Source located external to the chamber. A conduit connects the plasma Source to an interior region of U.S. PATENT DOCUMENTS the chamber to provide a reactive Species to the chamber interior for cleaning interior Surfaces of the chamber. A 4,461,783 * 7/1984 Yamazaki SL LSSLLSSLLSL LSSLLSSLLSSLLSSL LSLLSLLSL LSSLLSSLLSSL LSLLSLLSL LSSLLSSLLSSL LSLLSLLSL LSSLLSSLLSSLLSL LSSLLSSLLSSL LS 427/39 shower head, disposed between the plasma Source and an 4,615.298 * 10/1986 Yamazaki .118/723 interior region of the chamber, can serve as an electrode and 4,716,852 * 1/1988 Tsujii et al. .......................... 118/720 ...??? ?? 5,000,113 3/1991 Wang et al. ... ... 118/723 also can serve as a gas distribution mechanism. The shower 5,010,842 * 4/1991 Oda et al. .. ... 118/723 head includes a Surface treatment, Such as a non-anodized 5,082,517 * 1/1992 Moslehi ................................ 156/345 aluminum Outer layer, an electro-polished Surface of bare 5,449,410 * 9/1995 Chang et al. .................. 118/723 ER aluminum, or a fluorine-based protective outer layer. The 5,518,572 * 5/1996 Kinoshita et al. ................... 156/345 Surface-treated shower head improves the rate of removal of 5,552,017 9/1996 Jang et al. ..... 156/643.1 materials deposited on the interior Surfaces of the chamber 5,591267 * 1/1997 Ohmi et al. . ... 118/715 during cleaning, reduces contamination of Substrates during 5,599.397 2/1997 Anderson et al ... 118/728 processing, and provides more efficient use of the power 5,628,829 * 5/1997 Foster et al. ... ... 118/723 E Source used for heating the Substrate during processing. 5,718,795 * 2/1998 Plavidal et al. ... 156/345 5,788,778 * 8/1998 Shang et al. ............................. 134/1 5,892,886 * 4/1999 Sandhu ................................. 392/416 6 Claims, 4 Drawing Sheets


We propose an electron maser operating in the THz frequency range and based on the excitation of not a fixed transverse mode of the operating cavity but of a super-mode formed by a fixed set of the transverse modes. This allows selective excitation of a THz operating wave in an oversized microwave system fed by a high-current relativistic electron beam.


Hypocreales (Sordariomycetes, Ascomycota) is a highly diversified order, with more than 1000 entomopathogenic species being reported in Clavicipitaceae, Cordycipitaceae, Ophiocordycipitaceae and Polycephalomycetaceae. Taxa in these families form intimate associations with members of up to 13 orders of Insecta and other arthropods. Their variable morphological characteristics along with the host affiliations have played important roles in the classification of entomopathogenic species. However, it is still unclear whether these morphological characteristics are informative at the family, genus or species level in a phylogenetic context. This study focuses on entomopathogenic taxa collected from Thailand and Southwest China. Thirty-six species belonging to the above four families were identified using morphology and phylogeny inferred from combined data of LSU-SSU-5.8S-tef1-rpb1-rpb2 sequences. Among them, Pleurocordyceps ophiocordycipiticola is a new species. Divergence time estimates indicated the crown age of Hypocreales at 200 Mya, while that of Clavicipitaceae was at 107 Mya, Cordycipitaceae at 129 Mya, Ophiocordycipitacae at 121 Mya and Polycephalomycetaceae at 74 Mya. Based on ancestral character state reconstruction, the ancestral ecologies of Clavicipitaceae, Ophiocordycipitaceae and Polycephalomycetaceae were animal-based, while that of Cordycipitacae was fungi-based. Multiple interkingdom jumps occurred in all entomopathogenic families. Mapping of morphological characters on the phylogeny identified cases of association of perithecial arrangement and stromal texture. Ascospore and secondary ascospores morphologies were not informative at genus and family level classifications. Expanding collections to additional hosts and environments will assist towards further understanding the diversity and ecology of hypocrealean entomopathogens. Key word – 1 new species – China – Evolution – Phylogeny – Taxonomy – Thailand Mycosphere 13(2): 281–351 (2022) www.mycosphere.org ISSN 2077 7019 Article – Special issue Doi 10.5943/mycosphere/si/1f/8


We treated the sperms of domestic pig with weak electro-magnetic pulse field and compared the shape change of the sperms.we observed that Trypan Blue can enter the sperm cells and there are obvious holes in the cell surface by scanning electron microscope. It was confirmed that weak electro-magnetic pulse field can cause electroporation of domestic pig sperms and make the little exogenous molecules enter the sperm cells.


The realization of human capital values in universities not only depends on the sensible methods of fixing price which can recognize its own value,but also relies on the rational incentive measures which can bring about the effective investment.In fixing the price of human capital in universities,it is necessary to consider the capital attribute of human capital from the angle of investment,it is also essential to think of the running law of human capital from the angle of production.Therefore,the incentive of human capital in university should be based on the price of human capital and embodies the dominant demands of human capital.


Background: APOBEC mutagenesis underlies somatic evolution and accounts for tumor heterogeneity in several cancers, including BC. In our clinical experience, HR+HER2- BC with an APOBEC signature do poorly on standard of care (SOC) first line endocrine therapy (ET) + CDK4/6 inhibitor (CDK4/6i) and need additional treatment options. Here we evaluated the characteristics of a real-world cohort for time-to-treatment discontinuation (TTD) and overall survival (OS) on SOC and immune checkpoint inhibitors (ICI).Methods: Hybrid capture-based comprehensive genomic profiling (CGP) results from 29,833 formalin-fixed paraffin-embedded tissue biopsies of all BC subtypes were analyzed. For outcomes (TTD and OS), this study used a de-identified nationwide (US-based) BC clinico-genomic database (CGDB, ~800 sites of care, 1/2011 - 12/2020). HR+HER2- metastatic BC pts who received first line ET + CDK4/6i were included (CGDB cohort).TTD was defined as the difference between the first and last drug episode within a given line of treatment (LOT). LOT were derived based on FH algorithms. OS was defined as the time from LOT start to the date of death or data cutoff. Log-rank test and Cox model were used to evaluate the difference in outcomes. To reduce the impact of confounding variables (Age at Dx, Stage at Dx, Tumor Type, Metastases sites, TMB group (≥10 vs <10), SOC treatment group, PIK3CA), inverse probability of treatment weighting (IPTW) was used. Eligible pts from Mayo Clinic and Duke University were HR+HER2- mBC with sequencing data from FMI between 9/2013-7/2020. Clinical data were manually extracted from Mayo and Duke EHR. Results: Of all 29,833 BC samples in the CGP cohort, 7.9% were APOBEC+ with high rate in invasive lobular carcinoma (ILC) 16.7% vs. 4.9% in invasive ductal carcinoma (IDC) and metastatic lesions 9.7% vs. 4.3% from breast. APOBEC+ samples had a higher median TMB 12.5 vs. 2.5 mut/Mb. In CGDB, 857 HR+HER2- BC met inclusion criteria; 69 (8%) pts were APOBEC+ and 788 (9.2%) were APOBEC-. APOBEC+ pts had significantly shorter TTD on SOC ET+CDK4/6i than APOBEC- pts, 7.8 (95% CI 4.3-14.6) vs. 12.4 (95% CI 11.2-14.1) months (p=0.0036). APOBEC+ pts also had noticeably shorter OS compared to APOBEC- pts, 32.4 (95%CI 19.8-47.4) vs. 40.5 (95%CI 36.9-45.7) months (p=0.06).Cox regression results indicate that the relative risk of shorter TTD for the APOBEC+ vs the APOBEC- was 1.6 (95%CI 1.03-2.39). Also, APOBEC+ pts had almost twice the risk that APOBEC- pts had of death (HR=1.96, 95%CI 1.2-3.3). In CGDB, there were 10 APOBEC+ pts who received ICI, 9/10 had evaluable TTD data, 4/9 were still on treatment as of Dec 2020. 5/9 received ICI monotherapy, 4 pts received ICI + chemotherapy. TTD ranged from 0.3 to 11.3 mo, 1 pt's TTD was > 6 mo. In Mayo and Duke cohort, there were 6 pts, 5/6 received ICI + chemotherapy. The TTD was 0.9-40.5 months with longest 2 pts receiving 5-FU plus ICI (11 and 40.5 months). To better understand the ICI treatment landscape, TTD in HR+HER2- hTMB MSS APOBEC- CGDB cohort (N=6) was analyzed: 5/6 had evaluable treatment data, 4/5 finished ICI treatment, 1 pt's TTD was > 3 mo, 0/5 had TTD > 6 mo. Conclusions: APOBEC+ occurs in ~7% of BC and is more common in ILC and metastatic lesions. APOBEC+ HR+HER2- pts had shorter TTD and OS on SOC ET+CDK4/6i relative to APOBEC- pts. However, TTD on ICI tended to be longer in APOBEC+ pts, but our data is limited, and more research is needed.
 CGDB APOBEC+ vs. APOBEC- with SOC 1st lineAPOBEC+ (N=69)APOBEC- (N=788)p adjusted (FDR)*Age at Dx, Median (IQR)59.0 (53.0, 65.0)56.0 (47.0, 65.0)0.102Stage at Dx0.067- 0-III52 (75.4%)505 (64.1%)- IV11 (15.9%)245 (31.1%)- Not documented6 (8.7%)38 (4.8%)Metastasis free interval, yrs, Median (IQR)5.2 (3.0, 10.5)5.1 (2.8, 9.3)0.734Tumor Grade0.104- Grade 12 (2.9%)49 (6.2%)- Grade 234 (49.3%)259 (32.9%)- Grade 311 (15.9%)163 (20.7%)- Not documented22 (31.9%)317 (40.2%)Tumor Type0*- IDC7 (10.1%)251 (31.9%)- ILC30 (43.5%)138 (17.5%)- Other /Not documented32 (46.4%)399 (50.6%)Metastases sites0.734- Bone-only17 (24.6%)169 (21.5%)- CNS11 (15.9%)104 (13.2%)- Visceral41 (59.4%)514 (65.3%)TMB, Median (IQR)11.3 (8.8, 18.8)2.5 (1.3, 3.8)0*MSI0.946- MSI-H0 (0.0%)4 (0.5%)- MSI-I0 (0.0%)1 (0.1%)- MSS68 (98.6%)728 (97.2%)- Not documented1 (1.4%)16 (2.1%)BRCA5 (7.2%)45 (5.7%)0.734PIK3CA46 (66.7%)341 (43.3%)0.001*Treatments0.005*- AI + CDK4/6i31 (44.9%)510 (64.7%)- Fulvestrant + CDK4/6i38 (55.1%)278 (35.3%)
 Citation Format: Saranya Chumsri, Kira Raskina, Sarah Sammons, Laura Alder, Natalie Danziger, Alexa B Schrock, Kim McGregor, Ethan Sokol. APOBEC signature, clinical characteristics, and outcome in hormone receptor-positive (HR+) HER2-negative (HER2-) breast cancer (BC) patients (pts) in real-world data (RWD) [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD14-09.


Delay is a crucial factor on the Internet especially for real-time applications like video or audio. The best-effort service model doesn't provide essential assistance to these applications because of the unstable queuing delays. In this work, we present the result of a measurement study designed to understand packet delay time and variation on the Internet. Measurements are performed between some vantage points in different countries using PlanetLab. Some statistical properties of the collected data were examined. It is inferred from the results that delay values are mostly appropriate for implementing real-time applications. Besides, delay over a path is stable in general while it has outliers from time to time. It means that distribution is right skewed. Values are clustered around the mode value and not dispersed too much.


Reflecting on the art installation Motion of Scales, which was temporarily installed in the city centre of Kolding, Denmark, as a part of the NORDES 2021 conference, this article explores the interrelation between body, material and its performative potential. Analysing the design process through description and observation of how it was experienced and interacted with by urban public, the design-led research aims to interrogate subjectivity, emotion and embodied knowledge in academic research and its methods. How could movement within scale open up new perspectives? Does material hold a potential to reveal new modes of thinking in design research? How and to what extent could emotion contribute to design practices?


Dimethoxy[n.2]metacyclophanes were obtained in 5—45% yields through [2+2] photocycloaddition of corresponding styrene derivatives. These cyclobutane-fused metacyclophanes were assigned to be of only syn conformation (n = 6, 8, 10, and 12). The cyclobutane ring exclusively took the opposite direction to the alkyl bridged chain.


Wall (P) comprising wall elements (B), having the following features: - each wall element (B) comprises a spacer (7) through a cavity opening on both faces vis-a-vis the spacer (7) and at least one attached face (5, 6) on one of the faces or opens the cavity, - the spacer (7) comprises shoulders (15) for positioning, - each wall element (B) is slidably mounted between two profiles (2, 3) forming a slide.


Synthesis of N-acylpyrroles in 45-85% isolated yield from primary aromatic amides and excess 2,5-dimethoxytetrahydrofuran in presence of one equivalent of thionyl chloride is reported. This method has several advantages including short reaction times, mild reaction conditions, and easy workup. The technique works particularly well for deactivated aromatic amides.


This paper presents 500Mbps 60GHz-band ASK transceivers as the first wireless transmission system for IEEE 1394 multimedia home networks. Direct ASK modulation and demodulation adopting heterojunction FET MMIC switch and detector enable a simple transceiver configuration. Error-free transmissions have been realized for higher than ¿47dBm received power. A couple of IEEE 1394 S400 (400Mbps) wireless adapters have demonstrated 12m line-of-sight transmission and room-to-room connections.


Geranium purpureum is winter-annual, self-pollinating herb common in anthropogenic habitats of southern Spain. It is rare, however, in natural habitats such as the open woodland-scrub vegetation of Donana, where populations are fragmented into patches associated with the dominant tree in the area. Factors limiting the fecundity and growth of individuals and, hence, population spread and persistence, were studied by combining seedling transplants, herbivore exclosures, and data on seed dispersal distances. Results indicate that the association is not due to properties of the soil under trees. Rather, the observed distribution results from the combined effects of intense herbivory in inter-tree areas, and a relatively inefficient (ballistic) mechanism of seed dispersal


The purpose of the present invention is to provide a wireless communication device and an antenna direction determining method, whereby the direction of an antenna can be simply adjusted at the time of installing the wireless communication device for performing point-to-point communication. A wireless communication device (10) relating to the present invention is provided with an antenna direction determining unit (30) that determines the antenna direction of the wireless communication device (10) to be used in point-to-point communication. The antenna direction determining unit (30) determines the main beam direction (θm) of an antenna (11) on the basis of symmetry of the directivity of the antenna (11).


The article examines a few commonly believed half-truths hoping that it will help materials, structural, and pavements engineers develop sound and effective quality assurance programs. Dispelling the more persistent myths that have gained a strong foothold can help engineers develop a better understanding of the concepts and principles needed to produce and implement sound and effective quality assurance specifications. The following eight myths deserve consideration: You can't inspect quality into the product; the ultimate goal is product performance; with the evolution of specifications come continual improvements in quality; quality assurance specifications provide higher quality than method specifications; percent within limits is the ideal quality measure; all pay adjustment schedules provide an incentive for quality; agencies need not measure materials and construction quality on a warranty project; buyers and sellers risks should be balanced. The more common myths discussed here are all simple or absolute statements that sound good or look good at first glance, The quality assurance practitioner should give these statements due consideration and thought before believing them. Identifying a myth helps reaching a better conceptual understanding that will promote better out-of-the-box thinking that is necessary for quality assurance to keep progressing.


Today's databases contain large amount of data. It is almost impossible to manually analyze
valuable decision data from large databases. There are many techniques that can be used to
automatically extract the knowledge from data stored in the database. One of the techniques is
data mining. This paper discusses the importance of data mining, the process of knowledge
discovery in database, the kind of data to be mined, the data mining task, data mining prototype
and discussion about data mining today and the next future.


the course of operation of 70 l UHP furnace in Chita Plant, Daido Steel, solid carbon has been injected in order to facilitate the reduction of FeO in slag and to improve the energy saving and heating efficiency. In this paper, the effect of the injection method on the reduction rate of FeO in slag is discussed in relation to the quality and size of carbon powder injected, injection rate and nature of molten slag. Moreover the relation between the fundamental data of waste gas and the degree of slag reduction has been comfirmed. The results obtained are summarized as follows:(1) Volatile matter in solid carbon gives a large influence on the reducing reaction. In the coke of higher content of volatile matter, the reduction is controlled by the chemical reaction, while in the coke o f lower content of volatile matter, the reduction is controlled by the transport of FeO in slag.(2) The reduction rate depends on the basicity of molten slag. The reduction rate increases as the basicity of molten slag increases.(3) Estimation of carbon content of molten steel for a rapid operation is found to be possible by the use of the fundamental data of waste gas.


A new model of random local magnetic anisotropy that is induced at a magnetic ion by the random crystalline field generated by the substitution of nonmagnetic ions of one sort for nonmagnetic ions of another sort in interstices of a magnetic lattice is suggested. A general procedure of diagonalization of the Hamiltonian of the crystalline field consisting of two contributions of uniaxial type, namely, of a regular type and a random type, is developed; using this procedure, analytic calculations of the spectrum of eigenvalues, wave eigenfunctions, and components of the tensor of exchange-nonenhanced magnetic susceptibility for moments J = 1 and J = 3/2 were performed. A new concept of concentrational spin-reorientation transitions of the easy axis-easy plane type, related to nonmagnetic interstitial impurities, was considered using a ferromagnet with a simple tetragonal lattice of magnetic ions as an example.


Introduction and Aims: H. pylori has been implicated in peptic diseases, some with detrimental consequences such as ulcer or cancer. Since considerable genetic heterogeneity has been observed within H. pylori population worldwide, it appears an ideal achievement to recruit PCR-based methods and design genetic markers which recognize isolates from normal and symptomatic individuals. In this study 61 H. pylori isolates from dyspeptic patients were fingerprinted by REP-PCR. Materials and Methods: REP-PCR was performed on extracted DNAs of 61 H. pylori isolates from 39 normal, 18 ulcer and 4 cancer patients. Synthetic 18-nt primers, specific for interspersed repetitive elements in the bacterial genome, were recruited. PCR conditions were optimized and reproducibility of the reactions were confirmed. The size and number of PCR products were determined and DNA fingerprints of all isolates were analyzed by NTSYSpc programme, and dendrograms were generated. Results: Among 39 H. pylori isolates from normal patients 28 comprised a distinct cluster and 5 clustered along with isolates from ulcer patients. The remaining 6 isolates comprised a separate cluster distinct from other groups. Among 18 isolates from ulcer patients, 17 classified in a specific cluster, only one isolate was clustered along with isolates from normal patients. Isolates from cancer patients consisted a quite distinct cluster. Conclusions: In this study REP-PCR was used to show that majority of isolates from normal, ulcer, and cancer patients have distinct fingerprints which can be recruited for predicting the outcome of the infection with certain H. pylori isolates. It is concluded that REP-PCR is an effective and reproducible technique for fingerprinting H. pylori isolates from different human origins. Â


This study is aimed to examine the effect of financial performance and financial policy using variables the Return on Equity (ROE), Return on Assets (ROA), Firm Size (SIZE), Debt to Equity Ratio (DER), and Earning per Share (EPS) towards firm value indicated by Price to Book Value (PBV) of plantation sector companies listed in the Indonesia Stock Exchange. The data is obtained from the company's financial statements for the 2016-2020 consecutive year. The data was processed using Multiple Regression Analysis with SPSS 25. The results showed that profitability indicated by return on equity (ROE) had a positive and significant effect on the firm value indicated by Price to Book Value (PBV). Return on Assets (assets) has a positive and significant effect on firm value as indicated by Price to Book Value (PBV). Firm size has a positive but non-significant effect on firm value. The debt to Equity Ratio has a significant negative effect on firm value. Earning per share has a positive and significant effect on firm value. Simultaneously, Return on Equity (ROE), Return on Assets (ROA), Company Size (SIZE), Debt to Equity Ratio (DER), and Earning per Share (EPS) has a significant effect on firm value as indicated by Price to Book Value ( PBV)


Web software development and cloud computing based on Service-Oriented Architecture (SOA) represent the latest parallel distributed computing theories, practices, and technologies. As a distributed software development diagram, SOA is being taught in many computer science programs. We do not suggest using SOA to replace the currently taught Object-Oriented Computing paradigm. As SOA is based on Object-Oriented Computing, we suggest teaching SOA as the continuation and extension. At Arizona State University, SOA paradigm is incorporated into our Computing Science program since 2006. This paper presents the topics of the related courses and the open resources created for the courses, which are available for public accesses, including textbooks, lecture presentation slides, tests and assignments, software tools, and a repository of components, services and applications.


Methodology The methodology used is qualitative with inter-views, document exploration and surgical aproach. Results A 52 -year-old perimenopausal female reported with the following symtoms ; abdominal distension, pelvic pain and mild sign of constipation. The patient was further examined with a ultrasound that revealed a multicystic pelvic mass suspected to be a ovarian mass. A laparotomy was performed. Smooth, thin walled cysts were spread across the omentum, uterine wall, vesical fold and bilaterally in the ovaries. The cyst were filled with transparent mucinous fluid. The ovarian cysts were multicham-bered. A total abdominal hysterectomy, bilateral salpingoophorectomy, and partial omentectomy was performed . Final pathologic evaluation revealed a benign cystic mesothelioma, endosalpingitis and adenomyosis.


When The Naked Ape was published in 1967 a new phrase entered the English language and many other languages besides. Desmond Morris's unique treatment of homo sapiens caught the imagination of the public and the media in an extraordinary way. In the three months after publication there were 1,883 column inches of reviews, scores of radio and television items, not to mention the gossip columns and newspaper cartoons. The Sunday Times called it 'the sort of book that changes lives'. Since then it has sold over eight million copies around the world. Now a captivating and pertinent collection of illustrations has been assembled to complement the arguments so provocatively and entertainingly conveyed in Dr Morris' text. Nearly twenty years after it first appeared we can reassess his controversial ideas with the help of the fifty-six pages of colour illuminating this beautiful book.


: Due to the growing concerns about environmental issues, quality of life and well-being, consumers are considering the importance of obtaining eco-friendly products or devices with green functionality features. This scenario led to the investigation of the influence of green features on the intention to purchase of convergent products, with hedonic and utilitarian bases. We developed a quantitative experimental research, with application of online questionnaires at a University in the State of Pará, aiming to study the smartphones and their different usability. The results indicate increased intention of purchase of devices with "green" features on both a hedonic and a utilitarian basis. However, the addition of "green" features was more significant in the hedonic base, suggesting a utilitarian justification, reducing the guilty feeling inherent to the acquisition of hedonic products.


Shoplifting causes heavy losses to retail trade. The economic extent of shoplifting is not known and probably varies between countries. Some of the culprits have long been called kleptomaniacs. The hypothesis underlying this study, based on detailed interviews with 50 shoplifters directly after having been caught red-handed, is that features of kleptomania-like behaviour may be common among 'ordinary' shoplifters but that all the diagnostic criteria according to DSM-IV are rarely fulfilled. Although none of the shoplifters in this study fulfilled the DSM-IV criteria, many of them reported impulsivity and thrill in connection with the crime, two of the basic criteria for kleptomania according to DSM-IV. Further, many of the shoplifters did not feel to be themselves during the crime indicating dissociative-like experiences, both of which have been described in kleptomania and compulsive buying. Our study supports the hypothesis that there are intermediate stages between kleptomania and shoplifting for personal need. As there are case reports indicating that treatment with anti-depressant pharmaceuticals may have a positive effect on kleptomania and compulsive buying one may question whether persons exhibiting such intermediate stages also should be offered pharmaceutical treatment. Further, in cases of compulsive and ego-dystonic shoplifting, the educational programme developed by Shoplifters Anonymous may be an alternative to fines, which probably have a very limited preventive effect.


Based on the analysis of economic and social development of Zaozhuang and throughput data of Zaozhuang Port,the throughput capacity of Zaozhuang Port in the 12th Five-Year Plan is forecasted using quantitative forecasting methods such as time series method,regression analysis,elastic coefficient and grey model,etc.and qualitative forecasting methods such as field interviews and expert analysis,etc.and a relatively reliable result is obtained.The predicted result may serve as a reference for the relevant departments to elaborate corresponding plan.


The power of all actual reactors is limited by the behavior of their fuel elements. Such an element is composed of a fuel Luranium), in which fission releases heat, and a protective sheath between the fuel and the coolant. Different solutions are considered to assure the passage of the heat through the sheath. (tr-auth)


An approach to the optimization of propellers is presented that is based on a helicoidal vortex model and the rigorous calculation of the induced velocities to maximize the thrust for a given output torque of the engine. The mathematical model is presented and the discretized equations are derived for the inviscid model and for the viscous correction. The design of a two-bladed propeller at low advance ratio is carried out and the distributions of circulation, induced velocities, chord and twist are obtained. Comparison with published data indicates that the method is efficient and flexible and produces detailed and accurate results.


Abstract : A family of two-dimensional potential flows is derived which may describe the interaction of a propulsion jet with the leading edge of a thin wing-in-ground effect at zero angle of attack with a deflected trailing edge flap. Assuming that such flows occur at the leading edge, the static performances of this arrangement-called the Power Augmented Ram Wing-are derived as functions of geometry. A minimum power point is found for given thrust and lift. At this minimum power point, the wing can be held about one-tenth of its chord above the surface while providing a lift force of about six times the installed thrust and recovering about four-fifths of the installed thrust.


"Micro-course" is a teaching reform method that can combine various resources organically and enable students and teachers to gain new experiences. It also can expand students' knowledge and make the teaching content accurate, more professional, more in line with the needs of students. Many students who major in textile are liberal arts students, so using micro-teaching can better display the knowledge points of teaching and simplify the teaching difficulties. As a result, students can easily understand the knowledge points and master relevant major skills. Introduction "Micro-courses" are different from traditional teaching resources. They are classroom teaching videos that include teaching design, teaching cases, teaching reflections, student exercises, and teacher reviews related to classroom teaching topics [1-3] . So they are a new type of teaching resources. With the introduction of the concept of "micro-course", each school hold the competition, and each teacher had a familiar understanding of the "micro-course". This new teaching concept has gradually penetrated into the teaching of various courses [4-6]. Many of the students who major in textile are liberal arts students in our college. They have little knowledge of chemical knowledge, and they have never met all kinds of dyeing and finishing equipment. "Textile Dyeing and Finishing Technology" is a professional development and quality course for modern textile technology [7-9]. This course is designed to serve students with high-quality employment. With the aim of cultivating technical and innovative talents, we combined with the related textile professional knowledge, so students can be proficient in dyeing and finishing related equipment, familiar with dyeing and finishing quality inspection standards, and learn textile testing. In addition, students can master the basic knowledge and skills necessary for jobs in textile trade. The course of "Textile Dyeing and Finishing Technology" has relatively few class hours, but the micro-course allows students to understand more dyeing and finishing related knowledge in a shorter period of time. Favorable Conditions for the Implementation of Micro-course Rich Equipment Resources and Excellent Teachers The Dyeing and Finishing Training Center has a variety of dyeing prototypes, pre-treatment equipment, finishing equipment and textile testing equipment for integrated teaching. The Eco-Engineering Center has relevant dyeing equipment, which provides a successful implementation of the integrated teaching of the course. Our school is also rich in hardware resources. The school-enterprise cooperation unit of Jiangsu Nanwei Yueda Fiber Co., Ltd. has a dyeing factory and a finishing workshop. Their equipment is relatively complete, and it can provide the shooting scene and the production of shooting machines. The course team has high-quality teachers, including 3 teachers with senior professional titles and 4 teachers with intermediate professional titles. All teachers are double quality and there are 3 part-time teachers from the company. All teachers have many years of practical experience in integrated teaching and curriculum construction. Wireless Network Covers the Entire School Our school is covered by digital wireless network system, so teachers can transfer micro-course resources to each student through the course website, WeChat, QQ, online learning platform and other ways, and students can get rid of time and space constraints and achieve personalized self-learning by themselves according to their own actual needs. As a result, most of the students can master the details of related operating skills about pre-treatment, dyeing, printing, finishing. The Production of Micro-course Resources is Guaranteed The teachers of the course group work conscientiously and can make full use of the spare time to produce micro-courses. The college has a propaganda department where there are special students engaged in filming, cutting, editing, etc. It can produce micro-course resources of dyeing and finishing technology for integrated teaching, which are suitable for the students who major in textile. Design and Implementation of Micro-teaching Content The construction of the course is oriented to the high-quality employment of students. Our training objectives are mainly to cultivate practical hands-on ability and supplemented by theory. The combination of micro-teaching methods and integrated teaching methods can better realize "doing from learning", quickly improve students' understanding of related dyeing and finishing instruments and equipment, and master the operation skills of important equipment such as high temperature and high pressure dyeing machines. Cherry-pick the Teaching Content We are aware of the fundamental expertise and skills required of technicians by on-site research and graduate interviews (textile graduates engaged in dyeing and finishing). Therefore, the micro-courses are divided into six major modules: common instruments, common pre-processing equipment operations, common dyeing equipment operations, common printing equipment operations, common post-processing equipment operations, and related dyeing and finishing experiments. Each module contains several specific micro-units to ensure that students can better learn each operational skill. Integrate Integrated Teaching into Micro-courses The micro-course can show the standard operation method and the wrong operation method to the students when explaining the normative operation of the experiment. At the same time, it also shows the students the products produced by the wrong operation specification, so that the students can recognize the influence of the standard operation on the product quality. In the process of micro-teaching, we should focus on demonstrating the details that are prone to errors, and the theoretical knowledge should be well permeated in the experimental operation training, then we truly achieve integrated teaching. Implement the Teaching Method of Integrative Micro-course Teachers transfer micro-curriculum resources to each student the course website, WeChat, QQ, online learning platform and other ways before the class. Our college has the Dyeing and Finishing Training Center and the Ecological Engineering Center, where teachers or enterprise part-time teachers can carry out on-site demonstrations in the teaching process. It can deepen the understanding of students. Then the students perform skills exercises and the teacher guides during the tour. If students encounter difficulties, they can solve the difficulties in operational skills by learning micro-course resources timely. So the students can achieve twice the result with half the effort through on-the-spot guidance through micro-courses. Advantages of Micro-course in the Integrated Teaching of "Textile Dyeing and Finishing Technology" Micro-course Guide Students to Love Major Because some students who major in textile are generally weak in chemistry, they are not interested in dyeing and finishing. Teachers can make a short video to guide these students to learn according to the teaching knowledge point and design novel and interesting questions to attract students' attention, which can pave the way for the explanation of the new lesson. Micro-course Integrates Teaching Resources and Save Teaching Time We first make a micro-course about dyeing and finishing equipment about 10 minutes. Students can familiarize with the relevant equipment and instruments through the micro-courses by themselves when they are preparing for class. Therefore, if students go to the dying training workshop for training, they can deepen their impressions. So that students can acquire more knowledge points in a shorter period of time. Good micro-course can reflect their own advantages and help teachers save time and achieve resource sharing. Combine Micro-course with Traditional Teaching, Raise Strengths and Avoid Weaknesses In the dyeing and finishing technology, the graduated pipettes is a precision liquid measuring instrument and the correct use of the graduated pipettes is very important. There are a lot of precautions for the graduated pipettes: (1) The requirements of graduated pipette before use. (2) The holding method of the graduated pipette. (3) The using method of rubber suction bulb. (4) Method of extracting liquid. (5) Method of releasing liquid. (6) Precautions for releasing liquid. When the teacher explains the above details in the training room, the students standing behind can't see clearly. If the details are enlarged step and combine with the teacher's on-site guidance by the micro-course. Then the students imitate the operation and can quickly grasp the relevant skills and knowledge points. In this way, the teacher does not need to demonstrate and explain the students many times, and the students can grasp these details. As a result, the teaching effect is improved. Micro-course Guide Students to Expand Their Knowledge Students can watch micro-courses before class, or watch micro-courses that are difficult to master after class. Teachers can also make micro-courses about the specific steps of some production equipment for students to watch. Each Micro-course is short and precise and the relevant questions raised by the teacher in the micro-courses, which make the students think and guide the students to see the next one or more micro-courses, thus expanding the knowledge of the students. Micro-course can Solve Difficulties in the Actual Operation Process For dyeing and finishing experiments, some experiments are only done once and the time of experimenting for students is relatively short. How can students complete the experiment and grasp the precautions of the operation? For example, when we do the desizing, scouring and bleaching experiment of cotton fabrics, the preparation of working solution, the adding order of hydrogen peroxide, caustic soda, sodium silicate and scour


The meaning of the word ''prairie'' seems to have changed in recent years, as the Silicon Prairie replaced the Silphium prairie. There are bewildering uses of prairie that have nothing to do with native grasslands. The word is often used in a generic way, such as calling farmland, a vacant lot, or other open space a prairie. It is frequently used evocatively, as in Lakewood Prairie, a subdivision without a lake, a wood, or a prairie; a shopping center with no prairie for miles around is called Prairie View. Oxymorons like prairie golf or prairie fishing are common. Prairie reverie is a thoughtful meditation on the disappearance of the tallgrass prairie.


The objective of this paper is to assess analyse and explain the structures and processes of migration and urbanization in Nepal from a development perspective based on secondary sources of data. For the purpose of diagnosis analysis and description of migration and urbanization in the country data were drawn from published sources including censuses and surveys. Historical trends of migration to urban areas were based on data and information gathered from other secondary sources. To assess the level of migration and urbanization relevant quantitative analyses such as correlation and regression were performed. The article concludes that migration in Nepal like elsewhere is a strong phenomenon but that the pattern is predominantly rural-to-rural rather than rural-to-urban. The study also concludes that while urbanization in Nepal remains low it is becoming recognized as one of the engines of growth and development. The notion of urbanization along with planned migration to a certain extent is one of the most viable processes of development for which immediate intervention is warranted. Long-term policies and short-term strategies on national urbanization and migration are required as part of overall national development.


Review(s) of: One kind of laughter starts in the brain and seldom gets much further than a chuckling at the back of the throat or a scornful wrinkling of the lips as we respond to - or, better yet, say - something witty. Another kind, louder and usually lewder, starts further down, and is synonymous with the belly. A smirking mouth can't hold it in; it erupts from inside you like lava, in fits that eventually acquire their own momentum. When the spasm is over, you are left exhausted, gasping for breath, sometimes aching despite your exhilaration. You've been turned inside out, and may wonder why you made such a spectacle of yourself and allowed your face to be distorted by those bursts of mad hilarity.


In this work we introduce a system based on natural language processing techniques which aim is to enhance social news media in Bulgarian. It solves the task of multi-class, multi-label classification of documents. We apply the algorithms to a collection of media articles from Svejo.net, a popular Bulgarian web resource comprising user-generated content. Our algorithms are one-versus-all classification methods widely used in the computational linguistics community. We describe the algorithms, the features employed and we evaluate the impact of the features on the performance of the models. Thereby, we show that knowledge about the user and user behavior can greatly improve performance. Also, despite the fact that our document collection is generated entirely by social media users, the quality of the classification results is comparable to that of previously reported studies. We address also the task of automatic keyword and keyphrase extraction from unstructured text, and suit it to the needs of Svejo.net for induction of'themes'. Themes are defined as text snippets that summarize the essence of an article. We evaluate the performance of several generic methods for keyword and keyphrase extraction on a corpus of articles in Bulgarian. The methods that we discuss rely on widely accepted information retrieval and machine learning techniques and are languageindependent. We also consider the effect of a stemmer component on the keyphrase extraction accuracy. The satisfactory performance of our models in spite of the limited linguistic knowledge incorporated in them recommends our models as a baseline for keyword and keyphrase extraction for Bulgarian language.


The development of the digital world, such as in the era of marketing 4.0, has found ways to make it easier for business people to sell their products. One of them is through online media or e-commerce. E-commerce acts as a complex sales medium which consists of sales, purchasing, payment, and online management activities. One of them is contained in a system that has been made in such a way as in the market. The research method used is to conduct a direct analysis of the Tokopedia.com marketplace through the website https://www.similarweb.com and through the analysis of the 5A framework approach to the application of marketing 4.0 as research indicators. The marketing strategy applied in the Marketing 4.0 era is a strategy that adapts to digital technology and current customer behavior. Networks on the internet are interconnected.


The product of two Schoenflies motion subgroups of the group of general displacements characterizes a noteworthy type of 5-dimensional (5D) displacement set called double Schoenflies or XX motion. It includes any spatial translation and any two sequential rotations whose axes are parallel to two given independent vectors. The irreducible factorizations of the 5D set of XX motions and their primitive generators are briefly recalled; various intersection sets of two XX motions are emphasized. Starting with a canonical factorization of XX product, the general case of the intersection of two XX motion sets is disclosed. Three special cases: 4-DoF Schoenflies motion, bifurcation of 4-DoF X motion and 5-DoF XX motion are obtained. Meanwhile, two general overconstrained 6H chains with one-dof finite mobility that is not paradoxical but exceptional are unveiled. The looseness of the concept of "3T1R" ("three translations and one rotation") motion is also confirmed with an example.


The present invention discloses a method for preparing a lead oxide storage material containing lithium. The method comprises: a carbon source, a lithium source, a lead source and water are mixed in the secondary direct drying in an oven at 60-160 ℃ 5-10 hours; the resulting solid product was calcined at temperature 600-900 ℃ 1-18h cooled to room temperature to prepare a lithium-containing energy storage material of lead oxide. Preparing a raw material readily available and inexpensive, simple and easy process, it does not produce gas pollution, lead oxide lithium-containing energy storage materials prepared includes the normal charge-discharge characteristics, product performance and stability, having a potential for lithium ion application storage of active substances, and is expected to become a lithium ion secondary battery active materials, it has a high commercial significance.


Although testosterone is the major circulating androgen in men, dihydrotestosterone (DHT) is more potent and is the major form of androgen found within the prostate gland.1 DHT, which is responsible for maintaining prostate growth, is produced through reduction of testosterone by an enzyme called 5-α-reductase.1 DHT is regarded as an extremely important factor in the pathogenesis of benign prostatic hyperplasia (BPH).2

There are 2 isoforms of 5-α-reductase (types 1 and 2). The type 2 enzyme predominates within the prostate and is localized to the fibromuscular stromal compartment.3 Therefore, finasteride, a selective competitive inhibitor of 5-α-reductase type 2, was developed to address the management of BPH.4 Accordingly, use of finasteride significantly reduces urinary symptom score, improves urinary flow rates, and reduces prostate volume in men with BPH.2

Like BPH, prostate cancer is known to be androgen-dependent, and finasteride inhibits the proliferation of prostate cancer cell lines both in vitro and in vivo.5,6 These findings incited the National Cancer Institute (NCI) and the South West Oncology Group (SWOG) to consider whether finasteride could reduce the risk of prostate cancer. In 1993, a large-scale study of prostate adenocarcinoma chemoprevention with finasteride was initiated: the Prostate Cancer Prevention Trial (PCPT). A recently published paper reports the findings of this important study.


Laboratory experiments were carried out on thread-bearing spat of the tellinid bivalve Macoma balthica, and in the field high numbers of these juveniles (of up to 1 cm shell length) were caught in winter in plankton nets suspended in tidal streams of the Wadden Sea (The Netherlands). These data are used to explain the distribution and dynamics of a population of the species in the North Sea off the West-Frisian island Terschelling. Evidence is presented that nearly all M. balthica arrive in this area in winter by secondary settlement after tidal current transport, facilitated by long hyaline threads. M. balthica were numerous only close to a tidal inlet connecting the area with the Wadden Sea. Further away (more than 10 to 15 km), young M. balthica arrived in low numbers only and were smaller. All or nearly all M. balthica in the North Sea will have originated from massive primary settlement of just-metamorphosed larvae more than half a year previously (in spring and summer) on high tidal flats in the Wadden Sea. Some functional aspects of dispersal by secondary settlement are discussed


Abstract
The title of this book suggests the possibility that new ways of managing innovative processes may favour an evolution of the economy towards an altruistic model. This chapter argues that the acceleration of innovative processes at the turn of the millennium has produced, or at least has not avoided, phenomena of the concentration of wealth and power in which it is difficult to discern an altruistic root. It is observed that the cultural models developed to interpret innovative phenomena are also focused on the profit of individual companies and not on altruistic values. The author goes on to indicate the appropriateness of referring to less limited phenomenological models and suggests exploring an analogy of innovation with Darwinian evolution. An outline of this approach is provided.


Objective
To evaluate the accomplishment of residency training on different level of postgraduate residents' self-assessment of competencies under the "unification of four certificates" postgraduate residency training model.

Methods
The study conducted a cross-sectional survey of all the postgraduate residents in the hospital. The competency included 5 domains with 15 items, 3 levels were designed for each item from ACGME competency, and matched to the Chinese residency accomplished standard. The accomplished rates were counted from self-assessment results.

Results
There were 272 validated questionnaires received. The phased competency assessment could evaluate the difference between grades than accomplished standard. The accomplished rates of each domain and as a whole were lower as the grade up, with a significant difference. There was the same trend in all the 15 competency items.

Conclusions
The "unification of four certificates" postgraduate students could finish Chinese residency accomplished standard well, but couldn't get the ACGME competency. It's important to monitor and improve residents' competency levels of different grades, not only to finish the residency training time, contains and numbers.

Key words:
Unification of four certificates; Postgraduate; Residents; Competency; Self-assessment


Using findings from a federally mandated statewide study of homelessness in the state of Iowa, this paper presents methodologies developed to address various aspects of homeless research, including enumeration of the population, screening for reporting duplications, estimating the annual number of incidents of homelessness, and exploring county-level estimates of homelessness. After implementing an algorithm to eliminate duplicate reporting, and using the baseline unduplicated reported number of homeless persons, a statewide estimate of the number of homeless individuals was derived. Following further adjustments for differences in agency reporting practices and after extrapolating for nonreported time periods, we estimated the number of Unique incidents of homelessness experienced in the state during the year of the study (1997). The policy implications of these findings are discussed.


almost guarantees that she is a central character and that the play is set in Phthia. Major sections of the plot of Polyxene can be inferred from the fragments. Achilles' ghost appears in the prologue. Agamemnon and Menelaus quarrel about the timing of the departure from Troy. A messenger tells of the ghost appearing and prohibiting the army from leaving Troy. Far more conjectural are the following scenes. Neoptolemus and Polyxene argue their case before Calchas, to whom Agamemnon has deferred. Calchas declares that Polyxene must be sacriμced. Polyxene prophesies; then is led o¶. A messenger reports the sacriμce. Agamemnon and the chorus exit, to prepare to embark. The Polyxene–Neoptolemus debate is almost pure conjecture, but without it there is no evidence of the role Polyxene played. Troilus is of interest because it refers to the mutilation of a body (fragment 623). Achilles is thus associated with an atrocity that no one other than Clytemnestra is said to have committed in classical Greek literature. Aside from a eunuch who says the queen castrated him, little is known about this play. Polyxene, Hermione, Tereus and Phaedra are related to plays of Euripides in some way, and their reconstructions often involve a triangulation of Euripides, Sophocles and Seneca. Fitzpatrick and S. reject Ovid's account as a model for Tereus, especially concerning the remote hut and the Bacchic theme. Tereus contains the best-known fragment from Sophocles, Procne's lament. Despite the obvious parallels between Procne and Medea, their discussion of whether an audience would have approved of her is inconclusive. Talboy and S. discuss Euripides' two Hippolytus plays and Seneca's Phaedra extensively before moving to Sophocles' Phaedra. There is no plot reconstruction in this case. Early in the play, Phaedra explains that Theseus is in the underworld, and consequently the authors suggest her approach to Hippolytus is less questionable. If this is so, then one can see how Phaedra might be made to resemble Sophocles' Deianeira in Trachiniae. The Nurse then approached Hippolytus for Phaedra, and Hippolytus 'spat out' (678) the Nurse's suggestion. Mills, Shards 231, suggests plausibly that Phaedra spoke directly to Hippolytus. The authors have succeeded in demonstrating Sophocles' range, and his relationship to Euripides and Seneca. Although there is a need to create a protocol for depicting original and hypothetical elements, the value of reconstructions is obvious. S. and his colleagues have successfully made the fragmentary Sophocles accessible to a wider audience, while subjecting these fragments to an intense and creative investigation.


A three-phase three-level transformerless T-type grid-connected inverter system with three-level boost maximum power point tracking converter is introduced in this article for high-voltage high-power applications. First, the mathematical model of grid-connected photovoltaic inverter system is built. Second, a multiloop interleaved control scheme is proposed for three-level boost maximum power point tracking converter to reduce the ripple of the inductor current and balance the capacitor voltage of DC bus. A predictive current control method and a power feedforward strategy are also proposed for the T-type three-level inverter part to reduce the harmonic content of grid-connected current and to improve the dynamic response of the system, respectively. In order to solve complex algebraic computation of traditional space vector pulse width modulation or multi-carrier pulse width modulation method, a single-carrier pulse width modulation method is presented for T-type three-level inverter. Finally, all control strategies and modulation method are implemented on a single-chip digital signal processor. A high conversion efficiency, low cost, and low harmonic current could be obtained on a 23-kW experimental prototype.


Increases in the number of incarcerated parents have led to the implementation of parent training programs in prisons. Although many programs exist, programs differ in their design and methods of self-assessment. This article examines the current state of research on parenting interventions, including the types of programs available, the outcomes measured in each study, and the overall effectiveness of parent training. Variables that may affect program effectiveness, such as sentence length, educational level, and parent gender, are considered. The importance of primary prevention through parent training is discussed, including implications for social welfare and further scientific inquiry.


Magnetic domains play a fundamental role in magnetization processes. However, unlike in ferromagnets (FMs), the formation of domains in antiferromagnets (AFMs) is poorly understood because they are not favored by magnetostatics and are difficult to detect experimentally. In this paper, we create a synthetic planar AFM with tunable lateral coupling between neighboring FM regions to establish the role played by magnetic disorder in the formation of AFM domains. By directly imaging the synthetic AFM in real space, we observe that the AFM lattice spontaneously breaks up into domains following ac demagnetization. These AFM domains nucleate and pin at locally disordered sites that define their size and shape, which is explained with the help of a Gaussian random field Ising model. Furthermore, we can manipulate the AFM domain morphology by varying the interaction strength, which can be tuned with the geometrical parameters of the synthetic AFM. DOI: 10


Biological thiols are a class of labile and redox-active metabolite with significant interest to biomedical research due to their involvement in redox mechanisms of cell signaling and physiological control. As a result of oxidative stress, levels of various reduced thiols and oxidized disulfides are altered, which disrupts major cellular regulation pathways modulating protein function and gene expression. Thus, analysis of thiols in biological fluids is essential for understanding the role of oxidative stress and thiol dysregulation in aging and human diseases. However, reliable ex-vivo thiol determination is challenging due to their low abundance and susceptibility to autooxidation and thiol-disulfide exchange reactions. In this thesis, capillary electrophoresiselectrospray ionization-mass spectrometry (CE-ESI-MS) in conjunction with maleimide labeling is developed as an integrative strategy for comprehensive plasma thiol redox status analysis for metabolomics. Maleimide labeling helps to address both major constraints in thiol analysis by stabilizing free sulfhydryl groups as their thioether adducts while improving ionization efficiency and analytical sensitivity. This enhancement in ionization efficiency can be quantitatively predicted based on relative changes in fundamental physicochemical properties of thiols that occur upon covalent derivatization when using multivariate calibration. On-line sample preconcentration together with thiol-selective labeling using a cationic quaternary ammonium maleimide analog allowed for simultaneous analysis of reduced thiols and intact oxidized disulfides by CE-ESI-MS with low nanomolar detection limits of 8-30 nM. Improved identification of unknown low abundance thiols and other classes of polar metabolites is also demonstrated by


The first epitaxial films of bubble domain garnets were prepared by the chemical vapor deposition (CVD) method. However, liquid phase epitaxy (LPE) has rapidly become a very competitive technique. Despite the usefulness of both techniques in preparing research samples, their potential utility as manufacturing methods has yet to be demonstrated. The major portion of this paper presents the current status in this laboratory of the development of CVD as a manufacturing method. Subjects that will be discussed include reactor configurations, best film compositions, composition control, thickness uniformity, defect density, and film production rates. Finally, there will be a discussion of the relative merits of CVD and LPE.


Niosomes, a vesicular formulation, has been explored extensively for topical application to enhance skin penetration as well as to improve skin retention of drugs. In this study, three different rifampicin (1% w/w) niosomal formulations were prepared. Span 60, propylene glycol, dimethyl sulfoxide (DMSO), methanol and distilled water were used in the formulations. Different rifampicin niosomal formulations containing 12% (RN-F1), 16% (RNF2) and 20% (RN-F3) of Span 60 were prepared by injection method. Rifampicin content of each formulation was determined by UV spectrophotometer at 475 nm. Niosome particle size was measured by laser scattering method using Mastersizer 2000. Volume average diameter, d 50 of different formulations were found 8.488 nm (RN-F1), 12.533 nm (RN-F2) and 12.375 (RN-F3). Niosome preparations were also characterized by entrapment efficiency and in vitro drug release and pH stability test. Results of entrapment efficiency were found to be 55.11%, 57.66% and 60.17% for RN-F1, RN-F2 and RN-F3, respectively. Drug release pattern of RN-F2 and RN-3 formulations showed sustained release at controlled rate. All formulations were more stable at pH 5.8 to 7.0. Antibacterial effect of rifampicin niosomes was evaluated against S. epidermidis and S. aureus isolated from acne by antibiotic sensitivity and time kill study. The results of time kill study revealed that up to 96% of bacteria were killed within 4 hours. In this experiment, rifampicin niosomes were successfully prepared for the intention of targeting antibacterial effect in acne Dhaka Univ. J. Pharm. Sci. 14(1): 117-123, 2015 (June)


1. Based largely upon in vitro studies, vitamin E has been reported to inhibit phospholipase A2 activity, to alter phospholipid metabolism and reduce platelet aggregation.


We consider the problem of quadrilaterizing an orthogonal polygon P, that is to decompose P into nonoverlapping convex quadrangles without adding new vertices. In this paper we present a CREW‐algorithm for this problem which runs in O(log N) time using Θ(N/log N) processors if the rectangle decomposition of P is given, and Θ(N) processors if not. Furthermore we will show that the latter result is optimal if the polygon is allowed to contain holes.


T he Government of India initiated many employment generating programmes to address unemployment problem in rural area, however it remains major challenge to Indias development. The Mahatma Gandhi National Rural Employment Guarantee Scheme one of major flagship initiative which enhances the employment opportunity at rural area. The MGNREGA aims at to enhance livelihood security in rural areas by providing at least 100 days of guaranteed wage employment in a financial year to every household whose adult members volunteer to do unskilled manual work. Many research studies revealed that programmes have major impact on rural area, present paper outline the role of major employment programme in rural area.


The experiment was carried out by cucumber cultivar 'Xintai Mici' with weak heat resistance in climate chambers and hydroponics to investigate the negative effects of high temperature on AsA-GSH cycle and photosynthetic fluorescence characteristics of seedling leaves and the positive effects of exogenous proline pretreatment.The results showed that:(1)compared with the water treatment,under high temperature stress(treat 4 h,8 h).The activities of MDAR,the ratio of GSH/GSSG,and the content of GSH in leaves of cucumber seedlings were significantly increased in proline pretreatment.(2)Under high temperature stress(treat 8 h),proline pretreatment significantly increased Pn,Gs,Fv/Fm and qP in leaves of cucumber seedlings,but Tr and NPQ decreased.The results indicated that exogenous praline pretreatment significantly enhanced scavenging activity on H2O2 of AsA-GSH cycle and photosynthetic capacity in leaves of cucumber seedlings,and efficiently alleviated the injury of cucumber seedlings to antioxidant system and photosynthetic system under high temperature stress.Therefore,exogenous proline could enhance heat resistance of cucumber seedlings to high temperature stress.


The present state of our understanding of the mechanism of radical polymerization is summarized. The scope for control over the polymerization process so as to obtain predictable microstructure and reaction kinetics as well as optimal polymer properties is discussed and, where possible, illustrated by examples from current research.


Submitted for the MAR07 Meeting of The American Physical Society Renormalization of QED at Finite Temperatures. SAMINA MASOOD, Univ. of Houston Clear Lake — Renormalization of QED at different temperatures is studied in the background of real particles. It is explicitly shown that the second order thermal modifications to electromagnetic properties of a hot medium are nonzero at temperatures below the electron mass. However the second order contributions are smaller than the first order contribution at these temperatures which ensures the renormalization of QED in this situation. However, the situation changes at high temperatures. The overlap of hot infrared singularities in Lorentz invariance breaking formalism with usual cold ultraviolet divergences of vacuum has to be handled in a special order to avoid un-removable singularities. Samina Masood Univ.of Houston Clear Lake Date submitted: 20 Nov 2006 Electronic form version 1.4


Stratosphere-troposphere exchange (STE) events were identified over southern Brazil acting as a stratospheric ozone source to the Planetary Boundary Layer (PBL) during 2011-2013 period. There were 13 events with direct influence between 29° and 31° S (center of Rio Grande do Sul), with increase in ozone total column. In these cases, 4 occurred in 2011, 5 in 2012 and 4 in 2013. They were divided: in relation to the exchange latitude, the upper-level Jet Stream act, altitude of source and arrive of air parcels. The air parcels cross the tropopause between 120 and 320 hPa (dynamic tropopause), entering troposphere until the lower troposphere. Most cases (30,8%) reached 1000 hPa and the rest between 600 and 900 hPa. Just in one day the STE occurred in a lower latitude than 29° S; in all the other days (92,3%), STEs occurred in higher latitudes than 31° S (the closer it gets to the pole, the bigger is the ozone concentration, except in Ozone Hole Influence events) or between 29° and 31° S. In most cases (61,5%) it was observed STE along with the Jet Streak act.


PURPOSE: A memory cell and a memory device including the same are provided to reduce power consumption by storing light in a phosphorescence layer instead of a capacitor. CONSTITUTION: A light emitting unit(110) selectively provides a first optical signal in response to write data. A phosphorescence layer(120) provides a second optical signal by using energy provided from a first optical signal when the first optical signal is absorbed. A polarization filter(130) provides a third optical signal by passing the second optical signal or blocks the second optical signal in response to the write data. A light detecting unit(140) provides read data by sensing the third optical signal.


Nobody who would have visited German East Africa right before the war and had familiarized himself with its life, which visibly carries the imprints of sisal production, would have ever imagined that 22 years earlier no sisal agave nor any other fibrous agave existed in German East Africa.... It is my strong conviction that in no long a time East Africa will be the most important sisal producing area in the world (Richard Hindorf, 1925).1 Hindorf's conviction came true, and sisal's rise to prominence in German East Africa (GEA) continued unabated for almost three-quarters of a century. The signs of this ascendancy were already visible during the 22 years mentioned by Hindorf. The number of sisal plantations rose from 1 in 1893 to 54 by 1913, and production jumped from a mere 0.6 tons in 1898 to 20,835 tons in 1913, comprising almost 30 percent of the total value of GEA exports.2 Under the British Mandate, Tanganyika became the leading producer of sisal, contributing more than a quarter of world output. Until the late 1960s, "sisal was the gold of Tanzania."3 The first few years after independence die "mastery of sisal over the landscape," as Hindrof once noted, was still evident. In fact the year 1963-1964 marked the peak of the industry, when production reached 233,500 tons, contributing 35.6 percent of Tanzania's export earnings, employing 30-35 percent of wage labor, and covering 25.5 percent of total area under cultivation in the Republic. With 35 percent of total world output of sisal and 25 percent of world production of hard fibers, Tanzania was internationally acclaimed as the prime producer of hard fibers in the world. However, if the beginning of the twentieth century marked the undisputed rise of sisal plantations in Tanzania, the end of the century witnessed their demise, or in the language of the industry's participants, their "slow death" (kukufa baridi).4 "When I joined the industry in the late 1960s people used to say that I am joining a dying industry."5 From the late 1960s and over three short decades, the dying industry became the "dead" industry for many of its participants as well as outsiders. By the 1990s sisal production plummeted to 26,000 tons, contributing a mere 9 percent of total world output of sisal, 1 percent of total exports of Tanzania, and less than 3 percent of the total employed in the country. How could sisal-a foreign floral species from the Yucatan variably described as the "tree of wonder" and "an ugly but precious plant"6-master the regional landscape of Tanga in a few years and become the mainstay of the national economy for almost a century? Equally surprising, how could such a powerful industry be brought to its heels in a decade? I argue that the making and un-making of the sisal plantations in Tanzania was shaped by the multiple, and oft contradictory, agendas and actions of planters, workers, villagers and the state. In this paper I focus on the nexus of labor and land dynamics in Tanga Region. I argue that the colonial (German and British) attempts to establish European plantations as economic and sociocultural enclaves visibly marked off from the mass of nearby villages (i.e., markers of the divide between the so-called native and nonnative domains), were challenged by the actions of workers and villagers who merged the village and plantation in numerous ways to retain control over land and labor resources. By the 1960s, and despite the institution of a radically different regime of governance after independence, workers' and villagers' challenges to private and state plantations continued unabated. Attempts to stabilize the plantation labor force in the wake of nationalization were met with increased casualization of labor as well as intensified "use" of state-run plantation lands claimed by indigenous communities and workers as rights to public resources. Access to land and labor on the regional level shaped the very making of sisal plantations, with reverberations on the national economy and international markets. …


Abstract The palynological study of the Silurian and Lower Devonian strata in twenty-five petroleum boreholes in the western part of the Great Erg has led to a biostratigraphic zonation into four zones and nine sub-zones. The fossils collected in these boreholes have been used to attempt the correlation of these zones to chronostratigraphic units (from Middle Llandovery to the Siegenian). The geographic extension of each zone shows the approximate palaeogeographic history of these deposits and in particular demonstrates an important regressive phase from the centre of the basin towards the north.


The growth of Self Compacting Concrete is revolutionary landmark in the history of construction industry resulting in predominant usage of SCC worldwide nowadays. It has many advantages over normal concrete in terms of enhancement in productivity, reduction in labor and overall cost, excellent finished product with excellent mechanical response and durability. Incorporation of fibres further enhances its properties specially related to post crack behavior of SCC. Hence the aim of the present work is to make a comparative study of mechanical properties of selfconsolidating concrete, reinforced with different types of fibres. The variables involve in the study are type and different percentage of fibres. The basic properties of fresh SCC and mechanical properties, toughness, fracture energy and sorptivity were studied. Microstructure study of various mixes is done through scanning electron microscope to study the hydrated structure and bond development between fibre and mix. The fibres used in the study are 12 mm long chopped glass fibre, carbon fibre and basalt fibre. The volume fraction of fibre taken are 0.0%,0.1%,0.15%,0.2%,0.25% ,0.3%. The project comprised of two stages. First stage consisted of development of SCC mix design of M30 grade and in the second stage, different fibres like Glass, basalt and carbon Fibres are added to the SCC mixes and their fresh and hardened properties were determined and compared. The study showed remarkable improvements in all properties of self-compacting concrete by adding fibres of different types and volume fractions. Carbon FRSCC exhibited best performance followed by basalt FRSCC and glass FRSCC in hardened state whereas poorest in fresh state owing to its high water absorption. Glass FRSCC exhibited best performance in fresh state. The present study concludes that in terms of overall performances, optimum dosage and cost Basalt Fibre is the best option in improving overall quality of self-compacting concrete.


Automatic External defibrillators are today available in many public buildings. This article introduces the design of high voltage charger/discharger for automatic external defibrillator. Using the generated voltage to charge a capacitor for discharge a high energy and biphasic pulse is used. In animal experiment, our implemented circuit is considered to successfully deliver a high energy shock to an abnormal rhythm heart to chance to re-start with a normal rhythm.


Rhomboids are a familiy of intramembrane serine proteases whose active site is located inside the lipid bilayer of a bmembrane. In this work, new mass spectrometry-based methods were established and applied to identify new rhomboid inhibitors and to measure rhomboid enzyme kinetics. The successful analysis of new inhibitors and activity-based probes revealed new functional insights into these enzymes.


Objective
To investigate the relationship between urinary iodine level and prevalence of thyroid disease by comparing the levels of urinary iodine in patients with thyroid disease and healthy people in Hefei urban residents.

Methods
A prospective study was used in the study. A total of 238 patients with thyroid disease were enrolled in the Third Affiliated Hospital of Anhui Medical University from March 2015 to January 2017, and these patients were divided into three groups: Graves's disease (GD) group (n= 116), chronic lymphocyticthyroiditis (HT) group (n= 79) and thyroid nodule group (n= 43), 568 cases of Hefei urban residents without thyroid disease were selected as control group Urinary iodine was measured by arsenic-cerium catalyzed spectrophotometry. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were measured by chemiluminescence immunoassay. The thyroid was examined through B ultrasonography in both the case group and the control group.

Results
The median urinary iodine concentrations(MUIC) of GD group, HT group, thyroid nodule group and control group were 326.83, 361.49, 235.26, and 195.63 μg/L, there were significant differences in the MUIC between the 4 groups (H= 20.13, P 0.05).

Conclusions
According to the urinary iodine level in the normal population, the Hefei urban area belongs to the area of appropriate iodine. There was no corrolation between urinary iodine level and thyroid function in urban residents of Hefei.

Key words:
Urine; Iodine; Thyroid disease


This paper models household fertility decisions by using a generalized Poisson regression model. Since the fertility data used in the paper exhibit under-dispersion, the generalized Poisson regression model has statistical advantages over both standard Poisson regression and negative binomial regression models, and is suitable for analysis of count data that exhibit either over-dispersion or under-dispersion. The model is estimated by maximum likelihood procedure. Approximate tests for the dispersion and goodness-of-fit measures for comparing alternative models are discussed. Based on observations from the Bangladesh Demographic Health Survey 2011, the empirical results support the generalized Poisson regression to model the under dispersed data.


In order to solve the strategy optimization of Laser weapon intercept multiple in flight targets problem, a reasonable model is constructed and an improved Genetic Algorithm(GA) is proposed. It introduces both global search strategy and local search strategy to ensure the searching breadth as well as the solution precision. It adds a local search process in the standard GA. When the best child of every generation is found, the algorithm performs local search in the neighborhood of the best individual to find local optimum. It also applies keep the best K children of the parents to carry out mutation but not crossover mechanism. Experiments show that the improved GA greatly enhances the performance of the standard GA, not only improves the precision of the algorithm, but also increases the stability and quicken the convergent speed of the algorithm.