of Dissertation Presented to the Graduate Council of the University of Florida in Partial Fullfillment of the Requirements for the Degree of Doctor of Philosophy A HISTOLOGICAL AND PHYSIOLOGIC~L ANALYSIS OF ADVENTITIOUS ROOT FORMATION IN JUVENILE AND MATURE CUTTINGS OF Ficus pumila L. BY FREDERICK TRACY DAVIES, JR. December 1978 Chairman: Jasper N. Joiner Major Department: Ornamental Horticulture Adventitious root formation (~RF) was studied in three cutting types of juvenile and mature Ficus pumila L. (Creeping Fig). Leaf bud cuttings (LBC) were established as the ideal type for developmental sequencing research since difficult to root mature LBe responded positively to auxin and rapid de novo ARF was obtained to minimize environmental and physiological variables. Microscopic examination of ARF in juvenile and mature LBe indicated that both forms of cuttings exhibited remeristemation, early cell divisions (root initials), differentiation of primordia and root elongation. Primordia in juvenile LBe treated with indole-3-butyric acid (IBA) occurred at day 6 and in mature ones at day 10, roots emerged at days 7 and 20, respectively, with maximum rooting occurring at days 14


Aims : Rheumatoid arthritis (RA) and pigmented villonodular synovitis (PVNS) are aggressive diseases with progressive joint destruction. The present study aims to define cell cycle phases, polyploidy and the immunophenotype of proliferating synovial cells in both diseases.


SYNOPSIS. Sexual and asexual stages of a parasite found in the thrombocyte-like cells of some Tropidurus torquatus infected with Plasmodium tropiduri are described. The strong ultrastructural similarities between the gametocytes of this parasite and the gametocytes of P. tropiduri, and the finding of this parasite in lizards inoculated with P. tropiduri suggest that this malaria parasite can develop both in erythrocytes and thrombocytes. Evidence in favor of this hypothesis is discussed.


[translation: Assessment of Workplace Characteristics and Physical Activity Preferences as Integral Part of Physical Activity Promotion Strategies for Middle-aged Employees] Abstract in English on page 131


Proof. Take any disclosure rule (M∗, φ∗) that leads to a vertically inefficient allocation given the seller's best response and the consumer's optimal purchase decision with the tie-breaking. (Hereafter, I omit the caveat "given the tie-breaking rule.") Then, φ∗ draws a posterior x ∈ ∆(V ) at which trade fails to occur with positive probability.1 Without loss of generality, suppose that given x, the seller recommends product 1 at price vn. Consider the following disclosure rule φ∗∗: On top of the information that φ∗ discloses, φ∗∗ also discloses u1 ≥ vn or u1 < vn whenever posterior x is realized. ∗Bank of Canada (email: firstname.lastname@example.com). 1Because |V K | < +∞, without loss of generality, I can assume |M∗| < +∞. Then, each message is realized with a positive probability from the ex-ante perspective. This implies that there is an ex-ante positive probability event such that some posterior x ∈ ∆(V ) is realized and trade fails to occur.


A detailed analysis of the power demand of an ultraefficient lightweight-battery electric vehicle is performed. The aim is to overcome the problem of lightweight electric vehicles that may have a relatively bad environmental impact if their power demand is not extremely reduced. In particular, electric vehicles have a higher environmental impact during the production phase, which should be balanced by a lower impact during the service life by means of a lightweight design. As an example of an ultraefficient electric vehicle, a prototype for the Shell Eco-marathon competition is considered. A "tank-to-wheel" multiphysics model (thermo-electro-mechanical) of the vehicle was developed in "Matlab-Simscape". The model includes the battery, the DC motors, the motor controller and the vehicle drag forces. A preliminary model validation was performed by considering experimental data acquisitions completed during the 2019 Shell Eco-marathon European competition at the Brooklands Circuit (UK). Numerical simulations are employed to assess the sharing of the energy consumption among the main dissipation sources. From the analysis, we found that the main sources of mechanical dissipation (i.e., rolling resistance, gravitational/inertial force and aerodynamic drag) have the same role in the defining the power consumption of such kind of vehicles. Moreover, the effect of the main vehicle parameters (i.e., mass, aerodynamic coefficient and tire rolling resistance coefficient) on the energy consumption was analyzed through a sensitivity analysis. Results showed a linear correlation between the variation of the parameters and the power demand, with mass exhibiting the highest influence. The results of this study provide fundamental information to address critical decisions for designing new and more efficient lightweight vehicles, as they allow the designer to clearly identify which are the main parameters to keep under control during the design phase and which are the most promising areas of action.


Machine learning has shown great potential for classifying diverse samples in biomedical applications based on their Raman spectra. However, the acquired spectra typically require several preprocessing steps before standard machine learning algorithms can accurately and reliably classify them. To simplify this workflow and enable future growth of this technology, we present a unified solution for classifying biological Raman spectra without any need of prepossessing, including denoising and baseline establishment. This method is developed based on a custom version of a convolutional neural network (CNN) elicited from ResNet architecture, combined with our proposed data augmentation technique. The superiority of this method compared to conventional classification techniques is shown by applying it to Raman spectra of different grades of bladder cancer tissue and surface enhanced Raman spectroscopy (SERS) spectra of various strains of E. Coli extracellular vesicles (EVs). These results show that our method is far more robust compared to its conventional counterparts when dealing with the various kinds of spectral baselines produced by different Raman spectrometers.


[1] Averages of Halogen Occultation Experiment (HALOE) aerosol extinction at 121 hPa for 1993–1999 and Stratospheric Aerosol and Gas Experiment (SAGE II) aerosol extinction between 100 and 140 hPa for 1987–1999 are analyzed in the tropics (20°S–20°N). Multiple wavelength techniques for HALOE and SAGE II data are used to distinguish cirrus from aerosol observations following the eruption of Mount Pinatubo in 1991. SAGE II and HALOE cirrus extinction values are 34 and 28% less, respectively, in 1993 than in 1995–1999, while aerosol extinction decreases over the same time period. SAGE II and HALOE decreases in the frequency of occurrence of cirrus in 1993 are qualitatively similar to the SAGE II decreases in the frequency of occurrence of cirrus, discussed by Wang et al. [1995], after the eruption of El Chichon. Tropopause temperature anomalies in 1993 most likely do not account for the decrease in cirrus observed in 1993 by both the HALOE and SAGE II experiments.


Lads dressed in blue and gold framed by the flashing lights of the Christmas tree in front of the baby grand bleat holiday tunes some mumbling, others talking, most not knowing the words hum not yet able to read, those with colds hacking, sneezing, none of the age when voices change and play havoc on any semblance of tune. Pianist and scout mother banging and pleading, lift their voices to give structure to this rush of sound, so that some words or perhaps fragments of a passage can be recognized Deck the halls with boughs of holly, fa, la, la, la, la, la, la, la, la, la we wish you a Merry Christmas dreidel, dreidel dreidel, I made you out of clay like waves crash one after another without beginning, middle, or end. The audience, earthbound in this profane purgatory, held innocently for sins they cannot recall, wait as if they had all the time in the world immersed in this youthful display of valor and vigor, We'll do our best, with eyes watering and transfixed smiles heads bobbing on caved in chests they hear the voices of angels, and captivated they tremble no two beats in time like living ragtime dolls hands and heads, knees and feet they are mad conductors coaxing this choir to make ethereal music, and how the lads respond in kind to this cacophony of movement, it is their duty, is it not?


The distributions of 150 globular clusters in the Galaxy are analyzed under the galactic coordinate system.The results show that:(1)The 94% globular clusters are located in galactic latitude-50° ~+50°,while there are few globular clusters among galactic latitude +50°~+70°and-50°~-70°;(2)There are two peaks at galactic longitude 10° and 350°;(3)The nearest and furthest globular clusters are 0.68kpc and 123.33kpc away from galactic center,and about 68.7% star clusters are located in 10kpc from galactic center.All of the sample star clusters present a spherical symmetrical distribution around the galactic center.


In this paper, the benefits and drawbacks of incorporating technology into outdoor education are discussed. The data was collected during an inquiry based project for an educational technology course. This research is important because of the growing epidemic of children staying indoors with their technology rather than going and enjoying outside. There always seems to be a divide between outdoor education, or being outdoors in general, and modern technology. However, by using modern technology students may be engaged and drawn into outdoor education. Therefore, incorporating technology into outdoor education may be something to consider. This study analyzed the possible effects on students of incorporating technology into an experiential learning opportunity of being outdoors. The participants of this study were predominantly Education students at Mount Royal University, Education faculty members, as well as people from other occupational backgrounds who felt strongly about outdoor education.


We report on the discovery of three transiting super-Earths around EPIC 210897587, a relatively bright early M dwarf ($V=12.81$ mag) observed during Campaign 13 of the NASA {\it K2} mission. To characterize the system and validate the planet candidates, we conducted speckle imaging and high-dispersion optical spectroscopy, including radial velocity measurements. Based on the {\it K2} light curve and the spectroscopic characterization of the host star, the planet sizes and orbital periods are $1.55_{-0.17}^{+0.20}\,R_\oplus$ and $6.34365\pm 0.00028$ days for the inner planet; $1.95_{-0.22}^{+0.27}\,R_\oplus$ and $13.85402\pm 0.00088$ days for the middle planet; and $1.64_{-0.17}^{+0.18}\,R_\oplus$ and $40.6835\pm 0.0031$ days for the outer planet. The outer planet (EPIC 210897587.3) is near the habitable zone, with an insolation $1.67\pm 0.38$ times that of the Earth. The planet's radius falls within the range between that of smaller rocky planets and larger gas-rich planets. To assess the habitability of this planet, we present a series of 3D global climate simulations assuming that EPIC 210897587.3 is tidally locked and has an Earth-like composition and atmosphere. We find that the planet can maintain a moderate surface temperature if the insolation proves to be smaller than $\sim 1.5$ times that of the Earth. Doppler mass measurements, transit spectroscopy, and other follow-up observations should be rewarding, since EPIC 210897587 is one of the optically brightest M dwarfs known to harbor transiting planets.


Objective:To investigate the curative effect of modified Kidner surgery in treating congenital accessory navicular bone.Methods:From April 1985 to March 2003,34 patients(55 feet)who suffered from congenital accessory navicular bone were treated by modified Kidner surgery.Results:All patients were followed up for 5 to 21 years,with the average of 12 years,and the results were satisfactory.Conclusion:Modified Kidner surgery is an effective method to cure congenital accessory navicular bone.


Background: Dyslipidemia is a metabolic disease caused by an imbalance in cholesterol metabolism and is a major risk factor for cardiovascular disease. Bifidobacterium plays an important role in metabolic diseases such as obesity and diabetes. In most studies aimed at improving the lipid metabolism effects of probiotics, end products related to lipid metabolism were examined, whereas factors related to metabolic processes were not evaluated. Method: We prepared a rat model in which dyslipidemia was induced by feeding of a high-fat diet (HFD) and 25% aqueous fructose solution for 14 days. Compared to the normal diet groups, the HFD and 25% fructose solution significantly increased the levels of cholesterol metabolism-related factors. Result: Bifidobacterium breve strain IDBBR4401 was orally administered for 4 weeks, which increased the production of bile acid (+34.5%, P < 0.001) in the feces and low-density lipoprotein-receptor (+44.9%, P = 0.006), bile acyl-CoA synthetase (+43.8%, P = 0.008), and CYP7α1 (+48.0%, P = 0.003) in the liver. These effects promoted cholesterol metabolism and consequently reduced total cholesterol (-35.8%, P < 0.001), low-density lipoprotein-cholesterol (-32.7%, P < 0.001), triglyceride (-58.3%, P < 0.001), very low-density lipoprotein-cholesterol (-33.6%, P < 0.001), and ApoB (-55.2%, P < 0.001) levels in the serum. Conclusion: Our results suggest that ID-BBR4401 can be used as a probiotic agent to improve dyslipidemia by stimulating cholesterol metabolism in the body.


Objective To prepare propafenone hydrochloride(PPF) matrix pellets and investigate drug release mechanism in vitro.Methods The sustained release pellets were prepared using melted wax materials by extrusion-spheronization method.The formulation was optimized using orthogonal experimental design.Results The optimized formulation was PPF:SA:GMS:OA:CA:MCC= 3:0.5:1.5:2.5:0.5:2.Release of the drug from the pellets could be described with Hixson-Crowell equation and the main mechanism of drug release was dissolution,which was further proved by Ritger-Peppas equation.Conclusion Using different kinds of wax materials together could provide slow and steady release of PPF successfully.


Purpose
The Covid-19 pandemic has rekindled interest in sovereign debt crises amidst calls for debt relief for developing and emerging countries. But has debt relief lessened the debt burdens of emerging and developing economies? The purpose of this paper is to empirically address this question. In particular, the focus is on the implications of debt relief and institutional qualities for sovereign debt in emerging and developing economies.

Design/methodology/approach
The model extends the framework on the probability of default by incorporating the receipt of debt relief by a debtor country. Doing so allows to better explain movements of sovereign defaults relating to debt relief. The model is estimated via the regular probit regression.

Findings
The analysis shows that the debt relief provided, thus, far, failed to ease the debt overhang problems of developing and emerging countries and reduced investment. The current debt relief schemes may underscore the prospects of self-enforcing and self-fulfilling sovereign debt crises rather than eliminating the dilemma completely. Regarding the forms of debt relief, the analysis shows that debt forgiveness offers favourable prospects in terms of debt sustainability and economic outcomes than debt rescheduling. Perhaps, the sovereign debt crises, particularly in low-income countries, hinge on insolvency problems rather than transitory illiquidity issues.

Practical implications
Any debt relief mechanism should consider seriously the potential incentive effect that reinforces expectations of future debt-relief initiatives. Importantly, solving the sovereign debt problem requires a programme for sustained investment and economic growth, while not discounting the critical role of prudent debt management policies and institutions.

Originality/value
This study contributes a different angle to the debate on sovereign debt distress. Aside from the structural and economic factors, this study investigates the role of debt management policy in the debtor nation and the implications of debt relief benefits for sovereign risk. The framework also focuses on whether the different forms of debt relief exert distinctive impacts.


Researching on the 16 urban agglomerations,this essay builds up an evaluating system based on pressure for land development from three dimensions: endowment,environment and ecology.Using the entropy,this essay finds that: firstly,the urban agglomerations differ in the pressure for land development.The more developed and urbanized urban agglomerations usually face lower carrying capacity and higher pressure for land development.Secondly,the differentiation of pressure is mainly embodied in the dimension of ecology.Thirdly,the endowment scarcity doesn't match with the intensive use of resources.The urban agglomerations with higher endowment scarcity usually face higher pressure for land development.Finally,the environmental pressure of urban agglomerations can't couple with the treatment efficiency.According to the above research findings,this essay gives some advices from the selections of economic growth and coordination mechanism within regions.


Objective: There are few new approaches to the pharmacotherapeutic treatment of methamphetamine dependence in the literature. The publications contain abundant data on various methods of pharmacotherapeutic treatment of methamphetamine dependence. However, no pharmacotherapeutic therapy for methamphetamine dependence is sufficient. Materials and Methods: This was a double-blind study in patients diagnosed with methamphetamine dependence according to DSM-5. A total of 100 patients who met the DSM-5 criteria for methamphetamine dependence were examined. All male patients from 18 to 60 years old. The patients were divided into two groups of 50 people: the first group received clomipramine (anafranil) 300 mg / day (100 mg 3 times a day) and carbamazepine 600 mg / day (200 mg 3 times a day) orally. The second group received an indifferent drug (placebo) Results: as shown by follow-up data (12 months), among 50 patients who received anaphrani and carbamazepine only, 10 had short-term breakdowns associated with exposure to microsocial causes. The rest of the patients were in remission. Among patients receiving placebo, only 5 patients experienced remission, all the rest had cases of relapse. Responder analysis was performed using chi-square (x2) and analysis of variance (ANOVA). Conclusion. Clinical statistics indicate the high efficiency of the use of anaphrani and carbamazepine in the treatment of methamphetamine dependence. The mechanisms of action of the drug are being discussed.


(57) [summary] to maintain the quality in high grade over the [purpose] for several years, And quickly, and it can be manufactured at low cost manner, provides extremely accurate fine optics. CONSTITUTION: a support member to be made of a transparent inorganic material, a laminated optical component having a lacquer layer radiated curing having a specific composition on at least one surface of the support member.


The last works of Marzieh (Mari) Foroutan, an early-career martian geologist who was lost to us in 2020, have now been completed and published in JGR: Planets.


Fossil fuels reserves are limited and we will reach the peak oil very soon, if not already passed (http://www.oildecline.com). As we consume oil faster than we discover new reserves, the price will inexorably increase in the next years. We also know that in the future we have to reduce GHG emissions, of which large part comes from the transport sector, to mitigate climate change. Thus it is urgent to find alternative and sustainable energies. Biofuels or agrofuels, defined as solid, liquid or gas fuels derived from biomass, are today the only direct substitutes for oil on a significant scale particularly in the transport sector. The development of biofuel production may result in the decrease of the surfaces available for food production and then lead to a great instability of the staple food market and finally to a dramatic increase of the food insecurity. To avoid or minimize such negative impact, we have to identify new crop and define future ideotypes able to meet the energy demand without compromising food security.


Through the teaching of Yoga course for students,we think that the methods of scene guide,combining language explanation with intuitive demonstration,error correction,demonstration teaching,fun learning,evaluation and incentive,and mulit-level teaching can inspire students' enthusiasm for learning,and promote students' lifelong Yoga training very well.


In this paper we explore three approaches to assigning Gene Ontology semantic classifications to abstracts from the PubMed database: lexical lookup, information retrieval and machine learning. To evaluate the approaches we use two "gold" standards derived from the yeast genome database (SGD). While evaluation provides insights into the three approaches, it also reveals the difficulties in constructing a suitable gold standard for this task.


Strains of Listeria monocytogenes, Serratia liquefaciens, Shigella boydii, Staphylococcus aureus, Salmonella Enteritidis, and Bacillus cereus were used to evaluate bacterial biofilm-forming ability in trypticase soy broth (TSB; pH 6 and pH 7) at 37C. The biofilm development was determined by using the crystal violet method and the degree of biofilm formation was expressed as the specific biofilm formation (SBF) index. Among all strains tested, L. monocytogenes and S. liquefaciens formed strong biofilms in half-strength TSB (pH 6), showing 2.79 and 3.85 of SBF indices, respectively. The numbers of adhered L. monocytogenes and S. liquefaciens increased to 7.57 and 7.91 cfu/slide, respectively, after 36 h. The increase in the biofilm formation of L. monocytogenes and S. liquefaciens was shown in the scanning electron microscopy micrographs. The protein profile differences were observed between biofilms and planktonic cells, suggesting that biofilm-specific protein expression is involved in the biofilm development.

PRACTICAL APPLICATIONS

Since the biofilm formation has been a major concern to the food processors and medical devices, it is worthwhile to characterize the biofilm formation of foodborne pathogens under food processing-related stress conditions. The results suggest that foodborne pathogens have distinctive patterns of biofilm formation. Therefore, it might be useful information to better understand the mechanism of biofilm formation in different environmental conditions and evaluate the infectivity and pathogenicity of biofilm-forming foodborne pathogens.


This investigation is the second part of a two phase study of laminar boundary layers a t the high Mach numbers and stagnation temperatures encountered in hypersonic flow. The Prandtl laminar boundary layer equations for an adiabatic flat plate are solved using a finite element method with symbolic evaluation of element matrices for three different assumptions: (i) a perfect gas with constant properties and unit Prandtl number; (ii) a perfect gas with viscosity and thermal conductivity variation according to Sutherland's law; and (iii) a real gas with equilibrium properties. Results for each flow regime include streamwise and transverse velocity profiles, temperature and density distributions, and gas property distributions. Results for air considered as a real gas (chemically reacting mixture in equilibrium) are presented for Mach numbers to 30 with a constant temperature wall.


Despite its existence on the Chinese maps for more than six decades, the U-shaped line, as a traditional maritime boundary line of China in the South China Sea, has never received a wide recognition in the world community, much less by the other claimant states in the South China Sea. The U-shaped line is a legal conundrum not only for China but also for the world community, particularly after the map with the U-shaped line, together with China's Notes Verbale with respect to the claims to the outer continental shelves made by Malaysia and Vietnam, were submitted to the UN Commission on the Limits of Continental Shelf in May 2009. This article discusses China's recent practice relating to the U-shaped line as well as the external factors that affect the validity of the line and tries to unravel the legal puzzle posed by the line.


Career services professionals are increasingly involved in decisions regarding the use of technology. This article presents a number of considerations to be explored, including the characteristics and needs of today's students, available technologies, funding requirements, and confidentiality issues. The author recommends an approach that includes strategic planning, needs analyses, training, and ongoing support. Current asynchronous and synchronous technologies are described, and examples of the use of each in the context of career services are provided. The specific technologies presented are e-mail, discussion boards, video, podcasts, websites, Internet-based guidance and information systems, telephone, instant messages, and virtual rooms. The continuous advancement of technology makes the delivery of a wide variety of online student services more possible than ever. The existence of effective online career services may help students with the difficult task of balancing life and work by offering these services in alternative time frames and delivery modes. Balancing high tech and high touch is a desired outcome of technology integration (Giordani, 2006; Shea, 2005). Choosing to add technology to an existing program is choosing to add a new tool. Canili and Martland (1995) noted that "each technology has strengths and weaknesses and the choice depends on the task, the availability of equipment, and the cost" (p. 3). There is a widespread call for a strategic approach that can address the choices involved in detail. This approach should allow for consideration of a dynamic rate of change in the technologies available as well as the changes that take place in student demographics (Howell, Williams, & Lindsay, 2003). Today's Students Distance enrollment is on the rise, and the line between on-campus students and distance students is quickly fading. Even students thought of as traditional are likely to take an online course at some point in their undergraduate programs, and it is more likely that lst-year college students will have completed online courses before they even begin college (Howell et al., 2003). In 2006, the Michigan Department of Education announced a requirement for all high school students to complete an "online course or learning experience" (Nancy, 2006, para. 1) before graduation. This shift in enrollment is advanced by the desire of administrators at all levels to get students through academic programs in faster, more efficient time frames (Howell et al., 2003). The biggest high school class in U.S. history graduated in 2009. Many institutions began advance preparations for this population in anticipation of a rise in higher education enrollment. These preparations included the development of more distance options for students as an alternative to building larger physical facilities (Howell et al., 2003). Characteristics of a typical student are becoming harder to define as the student population becomes increasingly diverse in all aspects. Today's students can be characterized as multitaskers with "zero tolerance for delays" (Howell et al., 2003, p. 3). They also possess a level of familiarity with technology that breeds a level of expectation for availability of services and information at any time and in any place (Shier, 2005). Online Career Services One of the primary missions of the university career center is to help students make decisions and choices about their own careers (Hammond, 2001). Career centers established at higher education institutions are beginning to respond to the needs of various student populations that are working through the career decision- making process. Developing online versions of career centers to provide traditional career services to a wider range of students is part of this response (Davidson, 2001). Employers that hire college students are experiencing a similar shift in the use of technology. …


Abstract In 1958 soil was collected from a Connecticut cornfield, air dried and then stored in the laboratory. During the first five years of storage 31 species (in 17 genera) were isolated and identified. After storage for 10 yr (1968), 11 organisms (in nine genera) had survived; they grew when 0.5 g soil samples were incubated in several media. In the present 25 year study (1983) algal growth was noted in all 85 0.5 g soil samples incubated at 22°C. There were approximately 2000 organisms present per gram of soil. Protosiphon, present in 83 samples, was the most frequently observed organism. Seven species (in five genera) were still present in the soil after storage in the laboratory for 25 yr. Blue-green algae, detected initially and in the 10 year study, did not survive for 25 yr.


The activity ascribed to element 102 was made by bombarding Cm/sup 244/ with high-energy C/sup 13/ ions in the 225-cm cyclotron. The isotope produced was most likely either that of mass 253 or 251, made by the nuclear reactions: 3,6n)102/sup 251/. (M.H.R.)


I am greatly interested in Professor Rand's contemplated study of all unsupported Aldine readings in the Letters. With regard to the readings in this paper, however, of which some have slight MS support, while others rest solely on printed editions, I do not see how he can produce convincing evidence that Aldus followed P. If we cannot trust Aldus in one place, how can we trust him wholeheartedly in another? ALFRED P. DORJAHN WASHINGTON UNIVERSITY ST. Louis, Mo.


Natural resource conservation and its sustainable planning and development of a river basin can be done satisfactory by morphometric characteristics analysis. In the present study, Survey of India toposheets no. 45H/9, 45H/10, 45H/13, 45H/14, 45L/1 and 45L/2, were used to evaluate hydro morphometric characteristics (viz. Linear, aerial and relief) of Upper Berach river basin in GIS environment using the ARC GIS 10.1 software. Results reveals that the total area of river basin covers 1095.98 km2, which divided in two sub-basins, covers the area of 431.08 and 664.90 km respectively. Dendritic to sub-dendritic drainage pattern with stream orders of sub-basins, are found with ranged from VI to VII orders. Sub-basin stream length ratios are changing haphazardly which is indicating differences in slope and topographic conditions. Mean bifurcation ratio values vary from 3.28 to 4.13. Drainage density shows variation from 1.77 to 1.84 km/km in the whole river basin and sub-basins. The values of form factor and circularity ratio are varied from 0.15 to 0.23 and 0.24 to 0.47, in the whole river basin and sub-basins The ruggedness number of river basins, sub-basin-1 and sub-basin-2 are 0.83, 0.40 and 0.83.


In this paper, the mechanism by which current reflux forms from a plasma-focused electron beam is studied theoretically and numerically by considering nonlinear interactions between the beam and plasma. We demonstrate that a moving virtual cathode can be generated at the end of a plasma ion channel due to the influence of the boundary plasma electrons on the beam, and that this accounts for reflux formation. In addition, the reflux formation condition is derived and analyzed via the beam envelope and space-charge-limited current theories. The results indicate that the virtual cathode tends to form at defocusing positions of the beam. Particle-in-cell simulations are used to verify the theoretical results and to show that the beam divergence and energy spread increase during current reflux formation.


Abstract : The results are presented of the search for suitable saturable filter materials and the theoretical investigation of the saturation effect. The observation of saturation effects in uranyl glass filters is discussed. The effect of a saturable filter in the laser cavity is demonstrated with an experimental Q-switched laser.


The manifold, at times contrary demands and developments professionals in care and social work are confronted with, have led to a crisis in professional identity. The authors claim that an inductive strategy is a better strategy than a deductive strategy of knowledge development when the purpose is to strengthen the identity. The former strategy both relates to personal needs, values, knowledge and experience of professionals, ands offers some grip on knowledge development by the professionals themselves.
This is illustrated by a learning trajectory that was developed for social workers. Describing this trajectory and presenting an evaluation of the results, the authors conclude that the strategy of professional development does have learning effects, though these are restricted to the individual level and do not involve the organisational level.


The demand for water spinach is increasing but this commodity is not cultivated intensively. Theexperiment aims was to know the optimal interaction of harvest interval and application urea toincrease and maintain production of water spinach. Research was conducted to determine theoptimal effect of application urea and harvest interval to the regrowth and production of waterspinach at Tanjung Raya street, Medan Helvetia on January-June 2014 using split plot design withtwo factors, the factors were dose of urea (0;25;50;75g/plot/season) and harvest interval (every 8,10, 12 days after the first harvest). The parameters observed were shoots numbers, shoots length,primary and secondary branches number, fresh weight, consumable fresh weight per sample andproduction per plot. The results showed that the application urea with 75g/plot/season is better than0, 25 and 50 g/plot/season at the same time harvest interval treatment with 8 days is better than 10and 12 days after the first harvest.Key words : water spinach, urea, harvest interval.


An increasing incidence of hearing impairment and of reported problems with broadcast audio is leading to an increased demand for personalized audio services. Previous research has treated these issues as a 'speech in noise' problem; sounds are viewed as speech (good) or as competing masker (bad). This binary approach to accessible audio disregards the important role of some non-speech sounds in facilitating understanding of broadcast programme narrative. This work, as part of the S3A project, has taken a more holistic approach to audio personalization using categories of narrative importance to provide complex manipulations of broadcast audio based on narrative comprehension, instead of simply intelligibility. A simple, intuitive user-interface allows the user to adjust the complexity of audio scenes based on their personal hearing needs, metadata is generated at production using plugins to generate appropriate metadata and audio previews of user-narrative importance settings. This paper outlines the concept of narrative importance, the production tools and the end-user interface designed to deliver it. Response to these tools from target users and production staff are discussed as well as ongoing work.


Multiport converters are a promising concept for use in renewable-energy and hybrid power sources. These converters are highly beneficial, as conversion can be carried out in a single stage even while interfaced with multiple input power sources (hybrid). This paper provides an introduction to multiport converters and a comparison with conventional converters. The application of multiport converters with reference to renewable-energy sources along with the advantages and disadvantages of both types of converters are analyzed.


On November 12, 2021 at the University of National and World Economy under the patronage of the Rector Prof. Dr. Dimitar Dimitrov was held an annual scientific conference on "Economic challenges: crisis, recovery, sustainability". The special guest of the event was Mr. Atanas Pekanov, Deputy Prime Minister for the Management of EU Funds. The forum was attended by representatives of employers, trade unions, central and local government and NGOs. Guests were also Prof. Dr. Mihail Musov, Deputy Rector for Research and International Cooperation, and Prof. Dr. Rosen Kirilov, Deputy Rector for Digitalization and Cyber Security. As the organizer of the conference, Assoc. Prof. Dr. Ivaylo Beev, Head of the Economics Department of the UNWE, noted his satisfaction with the wide attendance at this traditional forum. He drew attention to the fact that despite its regular holding for the Department of Economics this is the most important event of the year. "This is the time when we check our watches with the college, with the practice, with the students and their views. The responsibility of this forum is to maintain the leading position of the department and the university in the development of economic science."


ABST RACT : In eve ry group, even in homogenou gro ups, the re are always different characteris tics of the members. Members may be different one fro m the others in terms of their demographic charateristics and personality d ifferences. D iversity among students can be regarded as the positive as we ll as negative value of student gro ups. It can be negative since diversity among mem bers o ften becomes the source of problems and conflict among members, which impede relationsh ips among members. Thi s paper discusses the negative value of diversity and com ponents wh ich are very essentia l for bui ld ing eff ctive relationships. Furthermore, the paper a l 0 elaborates condi tions needed to reduce prej udice as the result of diversity in educat ional se tt ings . Finally this paper attempts to cha llenge lecturers who are facilitators in the learn ing process to serve as models in build ing effective relat ionships and working with diversity.


The concept of I -convergence is a generalization of statistical convergence and it is depended on the notion of the ideal I of subsets of the set N of positive integers. In this paper for sequences in 2 -normed space the relationship between I -convergence and usual convergence along a filter F (I ) associated with an admissible ideal I with property (AP) is investigated. We introduce the concepts I -Cauchy and I ∗ -Cauchy sequences in 2 -normed spaces and study their certain properties. Mathematics subject classification (2000): 40A05, 46A70, 40A99, 46A99. Keywordsandphrases: Statisticalconvergence, I -convergence, I -Cauchy, I ∗ -Cauchy, 2-normed spaces.


In this study, obtaining phytochemical compounds from coffee bean husk (Arabica variety) under pressurized conditions (PLE) was investigated. For this, an experimental design was applied to evaluate the efficiency of the extraction in different conditions of temperature, solvent to husk ratio and composition of the hydroethanolic solvent and to determine the maximum extraction conditions of total phenolic acids (TPA). The dry extract obtained under different conditions and by Soxhlet extraction was characterized.The conditions evaluated in the PLE showed that the composition of the hydroethanolic solvent had a greater influence on the results and the maximum extraction of TPA in the liquid extract (3.61 mg CAE 100 ghusk‐1) was achieved with 50% (v/v) ethanol in solvent, 45 mL g‐1 and 80 °C. Under these operational conditions, the extract obtained showed high mass yield (GY) and antioxidant activity (AA). Under pressurized conditions, synergism between operational variables and obtaining phytochemical compounds could be observed. Comparing the techniques, PLE provided a higher GY and AA, demonstrating the efficiency and selectivity of this technique in obtaining biologically active compounds. The main phenolic acids identified in the dry extract were gallic and chlorogenic, indicating an important role as an antioxidant and suggesting potential for its use.PLE is a potential method for green extraction to obtain phytochemical extract from coffee bean husk, which, associated with the recovery of compounds by obtaining the dry extract, presents advantages related to storage and handling, representing a starting point for the development of nutraceuticals that can be easily used as ingredients or additives in the chemical industry.This article is protected by copyright. All rights reserved.


The article describes the problem of forming writing skills in Braille methodology in special schools (type III). The authors present the diagnosed results on the basic prerequisites to forming writing skills: skills in spatial orientation, tactile memory, motor and tactile skills. The results indicate the importance of preparatory work of a speech therapist for the development of these skills in the process of overcoming writing deviations.


Due to the breakthrough of computer technology and of the developmentof Internet, it is possible to find out lots of information availablefor network users. However, the abuse of information retrieval toolshas the side effects of information overload and inappropriateness.To solve those problems, a novel intelligent agent is proposed byincorporating with the current search engines of Internet.First of all, web-page information is functionally classified intointo eight categories: article summaries, seminar minutes, courseschedules, book instructions, FAQ, news, individual or group homepages, and company promotions and product advertisements.Based on the formulation and inference of Fuzzy rules, the proposedsystem can successfully recognize the categories of tested webpages.Experiments of classifying 811 web-pages show that the system canboth improve the efficiency of information searching and match thespecial demands of users. Therefore, the system is worth to befurther developed and commercialized.


Abstract Incontrovertibly, CHBC programs in developing parts of the world can be a panacea if their efficiency and effectiveness are enhanced or strengthened. The aim of this paper is to raise debates and discourses on the effectiveness of CHBC programs in some developing countries. The paper has relied on a review of literature methodology. Findings indicate that CHBC are generally made ineffective by: inadequate public support, inadequate government support, lack of human and materials resources, and lack of financial resources. The following have been suggested to bolster CHBC programs: increase public awareness and support, fostering a strong government- NGO partnership, mobilizing local funding, mobilizing adequate human and material resources, and adopting various ways of strengthening the effectiveness of the programs. The paper has theoretically been premised on the Sustainable Livelihood Approach (SLA).


Some hybrid aggregation operators have been developed
based on linguistic hesitant intuitionistic fuzzy information. The
generalized linguistic hesitant intuitionistic fuzzy hybrid
weighted averaging (GLHIFHWA) operator and the generalized
linguistic hesitant intuitionistic fuzzy hybrid geometric mean
(GLHIFHGM) operator are defined. Some special cases of the new
aggregation operators are studied and many existing aggregation
operators are special cases of the new operators. A new multiple
attribute decision making method based on the new aggregation
operators is proposed and a practical numerical example is
presented to illustrate the feasibility and practical advantages of
the new method.


The Rehabilitation and Coast Security Training Center is a place that designed to accommodate training activities from Coastal Rehabilitation and Coastal Management. The Coast Security Rehabilitation and Training Center is an organi-zation under the Regional Disaster Management Agency, in this planning the building will be designed in the Buleleng area due to several supporting factors, namely, in the province of Bali the Buleleng area has the longest coastline area others in Bali there are 172,301 Km (BPS Buleleng 2015). So that it needs a forum to train people to protect the coast and preserve the existing beaches, other factors that determine the Buleleng area, especially on Sawan Sangsit vil-lage, have similar organizations so expected the building designed will accommodate the activities of the existing or-ganization in the Buleleng area. In the process of designing the Beach Security and Rehabilitation Training Center, it starts from determining the theme by observing the condition of the surrounding area and adjusting it to local customs and culture so that the appearance of buildings can be in harmony with the appearance of the surrounding buildings and acceptable to the community.
Index Terms— training center, rehabilitation, coastal security, buleleng, bali.


High-frequency induction brazing of cemented carbide (WC–Co, K20) and alloy steel (AISI 4140) using Cu–Zn base filler metal was carried out. The relationship between microstructure and performance of the welding joint was investigated. It was found that the filler metal exhibited excellent wettability and metallurgical bond in the welding surface. As the heating rate reduced, welding joint appeared smooth without any visible crack. In the diffusion layer, some intermetallic compounds were observed, which were produced by the reaction of diffusion atoms. The microhardness in the middle of the welding seam was 168 Hv and it increased gradually when approaching to the edge of welding seam. With brazing temperature increased or heating rate decreased, the shear strength of welding joint increased first and then decreased. The machining test clearly revealed that the cutting temperature and the flank wear increased with the cutting speed rose. The welding joint had good shear strength when the temperature was below 500°C and the shear strength decreased seriously when the temperature exceeded 500°C.


We have treated six cases of the pressure sore with musculocutaneous flap.Surgical procedures were as follows, superior gluteal musculocutaneous flap in four cases of lumbo-sacral pressure sore and gracilis musculocutaneous flap in the cases of ishial pressure sore.Postoperative course was seem to be good in the short term follow up study.


of rubella which occurred in the Australian springl summer of 1940-1941, he also mentioned the concurrent epidemics of sore throats which arose in military camps (from which they derived their colloquial names of "Ingleburn throat" or "Puckapunyal throat") and spread to the civilian populations." Indeed, he suggested that these might have been streptococcal in origin and that "the rash diagnosed as 'German measles' may have been in some cases a toxic erythema accompanying a streptococcal infection".' These further epidemics in Australia at that time are more likely to be explained by adenovirus infection, a common finding in new recruit populations (1940 would certainly fit that requirement), for which an interesting association with rubella has been suggested.' Is it possible then that adenovirus had a role to play in the aetiology of CRS? A series of papers from China, following a widespread severe adenovirus epidemic in children in 1958, showed some interesting pathological findings and indicated a potentiating relationship between adenovirus and other acute infectious diseases. ,-, The diffuse vascular pathological findings in the Chinese adenovirus epidemic' were remarkably similar to those described by Menser and Reye in CRS,' with intranuclear inclusion bodies also being a common finding. The concept of viral-bacterium interactions as causes of disease and even widespread epidemics goes back to World War I' and was pathologically and clinically established by World War 11. .. ·" The concept of viralviral interactions causing severe and even lethal disease by means of complementation or recombination in vivo is of recent origin." Adenovirus, with its enhancer-like sequences" and other remarkable properties," could well have interacted with rubella virus to potentiate it in the twin epidemics of 1940-1941 in Australia, causing CRS in selected cases. Gregg wrote: "I have formed the opinion that the 1940 'German measles' epidemic differed greatly from the ordinary virus infection bearing that name.'" In the discussion following his paper, it is mentioned that "he felt it was virus plus". Recent evidence in virology and molecular biology, in conjunction with Gregg's astute clinical observations and the presence of concurrent epidemics, would suggest that the so-called congenital rubella syndrome was actually explained by rubella virus plus adenovirus. Patrick Gill, MB, FRCR 7 Kings Road Subiaco, WA 6008


In this article we are going to consider dust acoustic wave in dusty plasma whose constituents are inertial negative charged dust particles, Boltzmann distributed electrons and non-thermal distributed ions with variable dust charge. Using reductive perturbation method, we have obtained Korteweg-de Veries (kdv) and modified kdv(mkdv) equations. A Sagdeev potential for the system and stability conditions for solitonic solution are also derived.


NaCl tolerant cell lines were selected from irradiated callus, which were generated from seed cultures. M1-regenerates were obtained from the salt-tolerant callus cultured on the auxin-free medium for 30 days. Some regenerants were more tolerant than the parent variety (Dongjinbyeo) on a medium containing 0.75 % NaCl. Seeds (M3 5,000 lines) derived from M2 lines were grown to the 3 leaf stage. M3 lines were soaked with a 0.75 % salt solution for 3 weeks and 350 salt-tolerant genotypes were selected. Among the M3 350 lines, forty tolerant lines were selected from a saline field (10~14 mS) near the sea coast. Of the forty lines, two lines (18-1 and 50-1) showed more improved plant height, panicle length, tillering number, spikelet number and yield than those of the original variety. Thirty primers were screened and two RAPD markers were identified, which appeared in both the salt-tolerant lines (18-1 and 50-1). From DNA-hybridization experiments, it appeared that the fragment arose from the middle-repetitive copy sequences. The transcript involved in the marker showed a higher expression in the salt-tolerant lines than the sensitive lines. The salt-tolerant lines would be useful as a resource for salt-tolerant breeding.


The teliospores of Puccinia penniseti germinate within 48 hours if the optimum conditions of temperature and humidity are available to them. They have no resting period. On germination, they produce a three-celled promycelium in which the upper two cells contain nuclei and appear functional whereas the third, lowermost cell is without a nucleus. Each of the two cells normally gives rise to a quadrinucleate basidiospore, but occasionally uni- and binucleate basidiospores are produced. In these latter instances, the division of the nucleus in the basidiospore may continue until 8-16 nuclei have been produced. Presumably, all the nuclei but one degenerate before the basidiospore germinates to produce a monocaryon. A study of the nuclei in the promycelium as well as in the basidiospore shows that there are 5 chromosomes, 4 arranged in two pairs of different sizes, the fifth being the smallest and solitary.


[1] Regional formation of deep and bottom water masses around the Antarctic continental shelf is one of the most important processes contributing to variability of the global meridional overturning circulation deep cell. Southern Ocean hydrographic data collected during the years 1958–2010 indicate that dense shelf waters cooled and freshened during that period. In the surrounding open ocean, Antarctic Bottom Water (AABW) warmed, with no evidence of salinity change. As a result of source-water property changes, AABW exported from the Southern Ocean to the deep world ocean became lighter over the period analyzed. The average rate of density change within the areas that experienced statistically significant change was −0.0019 kg m−3 yr−1. For the last 20 years of the analysis, a negative AABW volume anomaly (relative to the half-century average, 1958–2010) was indicated, possibly due to production of a lighter AABW variety or to changes in formation rates. Over the entire five decades, the upper isopycnal of the AABW layer deepened at a rate of −8.1 m yr−1. Changes in fundamental hydrographic properties such as these can have important implications for long-term global ocean circulation and climate.


Objective: The objective of this work is to evaluate the performance of OS extract as a coating on biomaterial surfaces in preventing bacterial adhesion and biofilm growth, as an effective measure to combat Biomaterial associated infections. Methods: Here, we have incorporated the extract from a medicinal plant as a coating to biomaterial surfaces in order to prevent bacterial adhesion and biofilm growth. To this end, Ocimum sanctum (OS) oil extract is coated on biomaterials (polymethyl methacrylate and polystyrene) and bacteria such as Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa were allowed to adhere and grow for 1 hr, 3 hrs and 24 hrs. Results: A significant reduction (p<0.01) in number of adherent bacteria on OS extract coated surfaces compared to bare surfaces was observed at all-time points. The zone of inhibition of OS extract was observed for all the three bacteria and maximum inhibition was observed for P. aeruginosa (30 mm diameter) compared to S. aureus (25 mm diameter) and E. coli (28 mm diameter). Conclusion: Thus, OS oil extract could be a promising coating for reduction of bacterial adhesion and biofilm formation. Keywords: Antibacterial coating, Bacterial adhesion, Biofilm, Biomaterial, Biomaterials-associated infection, Ocimum sanctum.


Due to environmental and contextual changes, it is often required to configure and re-configure sensor network services. The burden of programming a sensor network, as a consequence of these changes, can be alleviated with a plug-and-play approach that allows dynamic adaptation of sensor network services. In this paper, we briefly present a semantics-based methodology to avail self-configuration of sensor services with minimal human intervention. We also provide a practical usage scenario and our preliminary work in this context.


【Poly(N-isopropyl acrylamide)(PNIPAAm) and its copolymer hydrogels crosslinked withN,N'-methylenebisacrylamide(MBAAm) and poly(ethylene glycol) diacrylate(PEGDA) were prepared and their characteristics including swelling/deswelling behaviors were investigated. The hydrogel, with lower gelation rate and higher transmittance was prepared when PEGDA was used as a crosslinking agent. The volume phase transition temperature of PNIPAAm hydrogel was not affected seriously by the concentration of monomer and crosslinking agent, whereas, that of copolymer hydrogel was increased up to 5 $0^{\circ}C$ by incorporating a small amount of SMA. In the case of copolymer hydrogel, higher volume phase transition temperature was obtained when PEGDA was used as a crosslinking agent, suggesting the chain length of the crosslinking agent has a significant effect on the volume phase transition temperature of P(NIPAAm-co-SMA) hydrogel. The pH dependence of the hydrogel was observed when PEGDA was used as a crosslinking agent as well as MBAAm. Larger pores were found at the surface of the hydrogel crosslinked with PEGDA, suggesting that the surface morphology has a close relation to the water contents and the volume phase transitions of PNIPAAm and P(N IPAAm-co-SMA) hydrogel.】


Objective To investigate the effect of native and modified BIGH3 protein containing an Arg-Gly-Asp-Arg-Gly-Asp(RGDRGD) motif on the migration of HCE cells.Methods Human fibroblast cells were cultured and the same cells were studied.HCE cell migration assays were performed in transwellplates(8 μm pore size).The undersurface of the membrane was coated with various concentrations of recombinant BIGH3 or modified BIGH3 containing an RGDRGD motif(10,20,30,100 μg/mL) at 4℃ and then blocked for 1 h at room temperature with PBS containing 2% BSA.Cells were suspended in medium at a density of 3.5×105 cells/mL,and 0.4 mL of the cell suspension was added to the upper compartment of the filter.Cells were allowed to migrate for 4 h at 37 ℃.Migration was terminated by removing the cells from the upper compartment of the filter with a cotton swab,and the filters were fixed with 8% glutaraldehyde and stained with crystal violet.The extent of cell migration was determined by light microscopy,and within each well,counting was performed in nine randomly selected high-magnitude microscopic fields.Results Modified BIGH3 protein increased HCE cell migration in a concentration-dependent manner.There was a significant enhancement of cell migration when the protein concentration was increased to 10 μg /mL,and it reached a plateau at a concentration of 30 μg /mL.Conclu-sion The BIGH3 with a RGDRGD mutation has a stronger promoting HCE epithelial migration than the wild-type one,and is very important to treatment of corneal epithelial wound healing in clinic.


This study aims to determine the affixes of verbs in arabic and indonesian language to find out the similiarates of two language from morphological, grammatical, and semantic aspects.  And predict the diffuculties that faced by students. And prepare the learning materials that are appropriate for arabic language student in affixing araic and indonesia verbs based on the result of research.  Thus study has reached the following results: first; they are 17 similarities and 69 differences between the arabic and indonesian language interms of morphology, grammatical and semantic, including changing the letters of the increase to six forms in the indonesian language, the triple verb that may be necessary exceeds its object, the terms have no special terms in the indonesian language, secondly; the existence of the expected obstacles due to the difference between the two languages, and the third; the application of a reciprocal study at the level of verbs plus in preparing an educational subject for indonesian learnes.


Objective: This study aimed to evaluate the first endodontic case experiences, self-confidence levels, and perceptions toward endodontic learning of final-year undergraduate students. Methods: An online questionnaire was emailed to 270 final-year dental students at 10 Malaysian dental schools. The questionnaire consists of 29 questions on students' experience, self-confidence, and perception toward endodontic learning. Results: The response rate was 74.4%. The most frequently treated case was tooth diagnosed as nonvital associated with periapical periodontitis. Most of the students perceived working length determination as the most difficult stage and reported having low confidence in locating canal orifices in multirooted teeth and achieving satisfactory obturation. Overall, the students were satisfied with the endodontic knowledge taught by their respective faculties. Conclusion: Endodontic teaching in Malaysian dental schools was perceived as satisfactory by most dental students. Although endodontic treatment is perceived as difficult, students demonstrated high confidence in carrying out this treatment. However, they had limited ability in treating the complex root canal system.


The proposed chapter presents a self-contained approach for the dynamics identification of parallel manipulators. Major feature is the consequent consideration of structural properties of such machines in order to provide an experimentally adequate identification method. Thereby, we aim to achieve accurate model parameterization for control, simulation or analysis purposes. Despite the big progress made on identification of serial manipulators, it is interesting to state the missing of systematic identification methodologies for closed-loop and parallel kinematic manipulators (PKM's). This is due to many factors that are discussed and treated systematically in this chapter. First, the issue of modelling the dynamics of PKM's in a linear form with respect to the parameters to be identified is addressed. As it is already established in the field of classic serial robotics, such step is necessary to ensure model identifiability and to apply computationally efficient linear estimation (Swevers et al., 1997; Khalil & Dombre, 2002; Abdellatif & Heimann, 2007). The case of parallel manipulators is more complicated, since a multitude of coupled and closed kinematic chains has to be considered (Khalil & Guegan, 2004; Abdellatif et al., 2005a). Beside the rigid-body dynamics, friction plays a central role in modelling, since its accurate compensation yields important improvement of control accuracy. If friction in the passive joints is regarded, the dimension of the parameter vector grows and affects the estimation in a negative way. To cope with such problem, a method for the reduction of the friction parameter number is proposed, which is based on the identifiability analysis for a given manipulator structure and by considering the actual measurement noise. The calculation procedure of a dynamics model in minimal parametrized form is given in section 2. Another important issue of PKM's is the appropriate design of the identification experiment, in order to obtain reliable estimation results. Two aspects are here crucial: The choice or the definition of the experiment framework at the one hand and its related experiment optimization at the other hand. Regarding the first aspect, the harmonic excitation approach proposed a couple of years ago for serial manipulators is chosen (Swevers et al., 1997). The method provides bounded motion that can be fitted in the usually highly restricted and small workspace of parallel robots. Thus, we propose an appropriate adaptation for PKM's. The experiment optimization is carried out within a statistical frame in order to account for


We consider the problem of minimizing, for a dataflow graph of kernel calls, the overall number of operand data transfers, and thus, the accumulated transfer startup overhead, in heterogeneous systems with non-shared memory. Our approach analyzes the kernel-operand dependence graph and reorders the operand arrays in memory such that transfers and memory allocations of multiple operands adjacent in memory can be merged, saving transfer startup costs and memory allocation overheads.


To evaluate the long‐term neurodevelopmental and behavioral outcomes in surviving infants of pregnancies with spontaneous twin anemia–polycythemia sequence (TAPS), to compare outcome between donors and recipients, and to investigate potential risk factors for neurodevelopmental impairment (NDI).


PURPOSE: A sliding door frame is provided to minimize injuries by including a shock-absorbing unit when a door is closed and a part of a human body is sandwiched therein. CONSTITUTION: A sliding door comprises a door(100), a crash absorption unit, a second vertical groove, a second combining projection, and a second jaw. The door is formed in the door frame forming a square opening to be opened and closed. The crash absorption unit comprises a body unit and a buffer unit. The body unit comprises a second combining projection and is formed of one between metal material and PVC material. The buffer unit is fitted and combined in the body unit. The second vertical groove is vertically formed on the other end of the door. The second combining projection is inserted into the vertical groove along the longitudinal direction of the second vertical groove.


Results are given of radiation resistance measurements made on 30 electrode pair interdigital transducers deposited on crystalline quartz for the purpose of generating acoustic Rayleigh waves. On the basis of these data, a delay line has been designed exhibiting the following characteristics: minimum insertion loss 9.8 dB, delay 9.6 µs, -3 dB bandwidth 3.5 MHz, input impedance 50 Ω at center frequency of 96.8 MHz, isolation 90 dB, spurious echo rejection > 20 dB.


The temperature-heat duty (T-Q) graph method is provided to save energy for the distillation process of the mixtures with wide-boiling range. It is a visual method to find the heat sources and heat sinks, to use different utilities reasonably, and to realize the energy recovery, such as the steam generation or the heat integration. Through adjusting the operating pressures of some different column sections, the heat integration can be realized, and the multi-effect distillation flowsheet can be obtained. One case is studied and the result showed that the given method is easy and convenient for the engineers to design or to retrofit the distillation process in the interest of energy saving.


AbstractThis chapter focuses on the TOPOI area Persons, which represents the relationship level in communication, and entails the identities of the conversation partners and their mutual relationship. This area is extremely important for intercultural communication, since people, when it comes to experiences of strangeness, often feel directly and personally affected as to who they are and how they experience their relationship with others.


the speaking of the truth, the observance of strict chastity, the circumambulating of images of the gods with the right side turned towards them' 1; Prince Mrgankadatta proceeds to walk round the tree in which the god dwells, with his right hand towards it 2; Ambapali, whose invitation was accepted by Buddha, 'rose from her seat and bowed down before him, and, keeping him on her right hand as she passed him, she departed thence.3 The P1ll7cll-KoslYalra, which the pilgrim of to-day performs round the holy city of Benares, is a modern and striking example of the old pradaksi?ra.~ It is an old way of paying respect


Modbus/TCP protocol was analyzed.The communication between kingview and ADAM6000 module was realized by using Modbus/TCP.On the one hand,the system carried out real-time monitoring of the entire production line.On the other hand,it controlled field devices independently to realize decentralized control and centralized management.Meanwhile,the system used optical fiber communication to simplify wiring and save cost.In practical application,the system is a rational design and stable operation.


Treaties governing nuclear-arms reduction and missile defences are languishing for political and more fundamental strategic reasons. START and the ABM Treaty reflect the logic of Mutual Assured Destruction, or MAD, the central organising principle of strategic-arms control during the Cold War. MAD's two basic tenets, as practised by the United States and the Soviet Union, were nuclear overkill and vulnerability to missile attack. Now that the Cold War is over, these tenets no longer command widespread public or congressional support in the United States. A sustainable and bipartisan basis for future US policies geared toward the reduction of nuclear dangers must be built on different ground. While nuclear deterrence will remain important in the twenty-first century, Cold War conceptions of MAD can no longer guide future US decisions regarding nuclear weapons and missile defences. The time has come to replace MAD with a new principle, one that embodies a cooperative approach to reducing nuclear threats.


The processing flow,technology operating essentials and product quality index were studied,and beef granule with vacuum soft package was made successfully.


Excerpt This case report is presented in confirmation of the observation that urinary obstruction may occur during the course of sulfapyridine therapy as a result of the formation of sulfapyridine ...


In the modern era of highly developed network information system,it is difficult for an organization's network administrators to know the true identity of the equipment which attempts to access corporate networks.Facing clever and well-funded hackers,users'e-quipments may unknowingly be infected with the deadly malicious software.Currently Trusted Network Connect(TNC) technology pro-vides a solution by network access control,which can protect the system from harms of viruses,worms and other malicious applications,PC and equipment.This paper analyzes the EAP-TNC protocol and its application.


The present invention relates to an apparatus to cut an injected object which includes: an injected object supply unit; an injected object horizontal alignment unit; a first robot picking and placing an injected object; a first cutting unit cutting the injected object on a primary cutting position; a second robot picking the primarily-cut injected object to move and place the injected object on a secondary cutting position or picking a portion except a plate body of the secondarily-cut injected object to place the portion back to a second cutting position; a second cutting unit secondarily cutting the injected object on a secondary cutting position or cutting the portion (A) except the plate body of the secondarily-cut injected object; a third robot picking the plate body of the secondarily-cut injected object to move and place the injected object on a packaging unit; a rotation unit rotating the portion (A) except the plate body of the injected object secondarily cut in the second cutting unit; an injected object alignment unit to align the injected object by a plurality of rollers; and a packaging unit packaging the plate body of the secondarily-cut injected object using upper and lower packaging rolls.


Indigestible glucans (IGs) are dietary fibers that can promote human health via fermentation by the gut microbiota, where their physico-chemical properties play a crucial role. This effect remains to be fully explored. The aim of the current study was to comprehensively investigate and compare the fermentation characteristics of IGs with various structural properties, as well as their effects on the gut microbiota. Barley β-glucan (BG), laminarin (L), yeast β-glucan (BY), pachyman (PAC), resistant starch (R), and litesse (Lit) were anaerobically batch-fermented using the human fecal microbiota for 48 h. All the IGs were utilized by the gut microbiota at different rates, and 2% of L, 14% of BG, 23% of BY and PAC, and 35% of R and Lit were unfermented at the 48th hour. During fermentation, mono-, di-, or trisaccharides were released from BG, L, and Lit, and the pH of broth was greatly lowered by IGs, especially BG and L, along with the production of short-chain fatty acids. Interestingly, PAC favored butyric acid production, while BG, L, and BY preferred propionic acid. Moreover, lactic acid, but not succinic acid, was detected in considerable amounts, but only with BG and L after 5 h. 16S rDNA analysis showed different microbial structures and the selective promotion of bacteria with different IGs, while only PAC did not decrease microbial α-diversity. Further qPCR analysis confirmed that BG was more potent at proliferating Faecalibacterium prausnitzii; BY preferred total bacteria, Prevotella, and Lactobacillus; and R favored Bifidobacterium. The IG-induced changes in the gut microbiota were strongly correlated with carboxylic acid production. In conclusion, the six IGs differed in fermentation characteristics and gut microbiota regulation capacity, and each one could have specific applications in human health promotion.


This article analyses 'new expressions of Islam' in Tunisia before the popular uprising in 2010–2011. It does so from an ethnographic approach through which the researcher follows people as they go about their daily lives. The four 'new expressions' which constitute the framework of the analysis are new in the sense that they have not been presented before, have a twist to them in either message or form, and have attracted very little attention from scholars both inside and outside Tunisia. The article concludes that Islam did not disappear in the decades under President Bourguiba and Ben Ali's rule, but shifted from the public to the private realm; that pictures, sounds, and changes in the physical surroundings created by the regimes within the area of Islam were important factors for peoples' experience of being in society; that many Tunisians were searching for values which could counter other changes in society; and that society did not remain silent, passive, or immune to reforms launched by the regime, but reacted and responded in ways which were originally detached from the regime and politics.


A gel permeation chromatography was used for determination of molecular weight distribution of extract from liquid humic acid fermentation of livestock manure.It has been discovered that during the production process,Mw-/Mn-ratio decreased from 223.3 in influent to 6.1 in effluent.It was suggested that Mw-/Mn-ratio be a parameter for quality control during liquid humic acid fermentation of livestock manure.


Synthetic peptides derived from naturally occurring host defence peptides (HDPs) have garnered significant attention as novel pharmaceuticals, particularly as alternatives to antibiotics and for immunomodulatory applications. One of the barriers to advancing synthetic peptides for therapeutic applications is their tendency to aggregate under specific ionic conditions similar to those they would encounter in vivo. Formulating peptides with biocompatible excipients that prevent solvent‐induced peptide aggregation represents a possible solution to this aggregation issue; however, this strategy has not been systematically explored. In the present work, we describe the screening of various polymeric substances (including hyaluronic acid, carboxymethyl cellulose and hydroxypropyl methyl cellulose) as formulation candidates for HDPs and identified derivatized hyperbranched polyglycerols (dHPGs) as a biocompatible excipient that limits peptide aggregation. Notably, the immunomodulatory activity of a synthetic innate defence regulator peptide, IDR‐1018, formulated with dHPG was retained when evaluated against both peripheral blood mononuclear cells and human bronchiolar epithelial cells in vitro. Further characterization of dHPG polymers revealed that decreasing the negative charge density on the polymer surface potentiated the cytotoxic effects of IDR‐1018, emphasizing the need to optimize this parameter for future peptide delivery formulations. Importantly, the dHPG formulated IDR‐1018 inhibited peptide aggregation in vitro in the presence of mucin as well as in vivo when injected subcutaneously into CD1 mice. This study highlights the potential use of dHPGs as formulation candidates for synthetic HDPs and identifies important considerations regarding their physico‐chemical properties and relevance to immunomodulatory applications.


About two years ago Dr. P. Basilewsky, Chief of the Entomological Section in the Royal Museum of the Belgian Congo, Tervuren, Belgium, kindly sent me a large collection of Thysanoptera (in alcohol) from the Congo for identification. Recently he has also loaned me some of Priesner's types (mounted on slides) for comparison with the unidentified material. Some of this Congo material is dealt with below.


We have long investigated the development and improvement of the artificial vessels. Recently, we tried to examine the substitution for the vena cava, the shunt between aorta and pulmonary artery as well as femoral artery substitution have also been examined in dogs using Gore-Tex grafts.In the preliminary study where canine femoral artery was substituted with Gore-Tex artificial blood vessels (inner diameter, 2.8mm), the graft was kept patent to some degree for three weeks after the substitution but all grafts were obstructed six weeks after.To obtain the better results in the small artery grafting, we used modified Gore-Tex graft of inner diameter of 3.0mm. In addition, a large dose of ticlopidine, a new platelet aggregation inhibitor, or aspirin was administered to dog before and after the surgery.In the control group without drug treatment, the graft patency for a long period was hardly observed, while all grafts were patent when ticlopidine or aspirin in a large amount was used.The histological and electron scanning microscopic findings of the grafts confirmed strong inhibitory action of ticlopidine and aspirin against blood platelet aggregation. Especially, in the ticlopidine-treated group, aggregated erythrocytes on the surface of the graft were fewer and the fibrin layer was thinner as compared to the aspirin-treated group.


Adolescence is a stage characterized by emotional, psychological, physical and social changes. When entering the university, it is common for adolescents to change their lifestyles along with their eating habits due to increased coursework, homework and socializing factors. These issues lead them to have less control over quotidian things such as diet quality and sleep. Unhealthy diets are a well‐known risk factor for developing metabolic, psychological and cognitive dysfunction, affecting their behavior, attention, learning, memory and decreasing school performance. The present study will describe the dietary and cognitive parameters in first‐year undergraduate students of health sciences at the Autonomous University of the State of Mexico. 125 18 to 21 year‐old freshmen, with variable body‐mass index participated in the study. Participants' eating habits were evaluated with 24‐hr food diaries, thrice a week. Food consumption frequency questionnaires were used to identify dietary parameters according to diet quality indexes. The Wechsler intelligence scale for adults‐IV (WAIS‐IV) was used to analyze four cognitive parameters: verbal comprehension, perceptual reasoning, working memory and processing speed. Preliminary results from 50 individuals have been completed. Healthier dietary parameters have been identified in men in comparison with women, having more balanced diets overall, according to national guidelines. Similarly, men showed higher average scores in the cognitive parameters assessed. Positive correlations were found between intelligence quotient and total calorie and saturated fatty acid intake in men (p=0.0001, Rho 1.000), as well as between processing speed and saturated fatty acids, lipids, cholesterol and carbohydrate intake in women (p=0.049, Rho 0.350). A negative correlation was found between working memory and vegetable intake (p=0.036, Rho −0.426) in men. Our preliminary data suggest that male freshmen eat healthier diets than women at the authors' academic institution and that their diets affect their cognitive performance. Additional assessments for sleep quality, exercise habits and self‐image are currently under study in this population.


The [CaMnO3 (CMO)/REMO3] (RE = Bi, La M = Fe, Fe0.8Mn0.2) superlattices show semiconducting behavior with transition temperatures (TEg) of 71, 127, and 151 K in the [CMO/BiFe0.8Mn0.2O3], [CMO/BiFeO3], and [CMO/LaFeO3] superlattices. The formation of a magnetic polaron is expected in the CMO layer of the superlattices at TEg, where carrier density drops. A weak ferromagnetic interaction at the interface is expected at room temperature, because the sheet resistance RS and the Hall resistance Rh show a quadratic behavior and anomalous Hall effect as a function of magnetic field. The mobility also drops at the temperatures where both the ferromagnetic and antiferromagnetic interactions are expected to coexist. With decreasing temperature, the mobility is still low but stable. We consider that the electron transfer took place owing to the cation intermixing, not to the polar/nonpolar discontinuity, at the interface in the prepared superlattices.


Squamous‐cell carcinoma of the head and neck includes a heterogeneous group of tumours of the upper air and food passages for which prognosis is difficult to assess. In fact, patients in comparable stages may have diverse clinical courses and responses to similar treatments. In order to better define the prognosis of each patient there is therefore a need to identify novel biological markers which reflect more accurately growth rate, progression and metastatic potential of each tumour. We assessed whether metastases correlate with micro‐vessel counts (i.e. intratumoral vascularity) using the CD‐31 monoclonal antibody (MAb) and p53 mutant protein expression, determined in the primary by immunocytochemical methods in 70 patients with locally advanced head and neck cancer. Patients were treated with concurrent chemo‐radiotherapy; 50 of these presented loco‐regional node metastasis at diagnosis whereas 3 cases, initially node‐negative, developed distant metastasis during the period of observation. No feature was predictive for objective response to treatment. The overall mean and median blood vessel density at "hot spots" was 37.42 and 36, respectively, and 57% of the tumours expressed p53 mutant proteins. These 2 biological markers were significantly associated. Patients with metastases (loco‐regional and distant) had a significantly higher mean blood‐vessel density than those without tumour spread. Also, patients with p53‐positive (+/ + +) tumours had a significantly higher incidence of metastasis than those with negative ones. Multivariate analysis showed that both vascularity and stage, but not p53 expression, are significant and independent predictors of metastasis in this series.


Recent observations of growing carrier waves in InSb suggest a new type of interaction involving electrons and holes which leads to a growing surface wave. A theory is presented which shows that the wave has a phase velocity near the electron drift velocity, and in the presence of a transverse magnetic field is unstable with very large growth rates.


Wildlife corridors between protected areas play a critical role in maintaining genetic flow between increasingly isolated populations of many species. The importance of wildlife corridors for African savanna elephants (Loxodonta africana) has been well investigated. However, African forest elephants (Loxodonta africana cyclotis) are difficult to observe in dense tropical vegetation and much less is known about their ecology
than about their savanna counterparts. The Sangha River forms an international border between Cameroon, Central African Republic and Republic of Congo and bisects the biologically rich transboundary Sangha River Trinational Conservation Area. The river serves as a primary route for human transportation and trade in the region, and therefore acts as a partial barrier to elephant movement between protected areas. We used a
reconnaissance survey technique and dung counts combined with a GIS analysis to survey elephant crossings on the Sangha River. At present, radio-collaring elephants in dense forest is both logistically difficult and expensive, and therefore ground surveys provide a cheaper alternative method for identifying major elephant movement corridors. Results will contribute to a more targeted approach to anti-poaching patrol efforts in
the transboundary area.


Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a rare, but serious complication, which has recently been more frequently reported. However, this entity is unfamiliar to radiologists. We report a case of BRONJ complicated by actinomycosis following a tooth extraction in a 68-year-old woman who has been treated with oral bisphosphonate for treatment of osteoporosis over the last 3 years and 3 months.


While the main ideas underlying Universal RL have existed for over a decade now (see [Hutter, 2012] for historical context), practical applications are only just starting to emerge. In particular, the direct approximation introduced by Veness et al. [2010, 2011] was shown empirically to compare favorably to a number of other model-based RL techniques on small, partially observable environments with initially unknown, stochastic dynamics. Since then, a variety of additional techniques have been introduced that allow for the construction of far more sophisticated approximations. This short paper collects together and reviews some of the main ideas that have the potential to lead to larger scale applications.


This article examines Iraq's transitional politics from June 2003 to the Constitutional Referendum of October 2005. It argues that the top-down political transition led by the United States and a narrow group of Iraqi elites was inappropriate for the task of reforming the Iraqi state and building democratic institutions. The article argues that, in countries going through regime change while also radically reforming the state, inclusive transitional institutions and consultative processes contribute to agreements being reached about the future of the state. Such transitions allow actors to guarantee the continued participation of opponents in the political process and to gradually develop agreements on constitutional questions. This did not occur in Iraq. An inclusive political process and a national debate on the country's future did not occur. Rather, a narrow group of political elites led the transitional process in the absence of wide consultations. The article argues that the management of Iraq's transition had an independent impact on the outcome of the transition, namely the failure to reach agreement on the sharing of political and economic power within one state by October 2005.


Retroviral vectors are a promising tool for gene therapy. However, there are two major problems to overcome if a viable commercial production process is to be established. These are the instability of virus particles and the low virus titres. The characteristics of the producer cells were determined in batch culture, semicontinuous culture and semi-continuous culture at 32°C. Additionally, cell attachment, growth and virus production on various macroporous microcarriers was assessed under static and stirred conditions.

Alternative strategies for the cultivation of cells were also investigated. These included spinner basket, packed bed and spinner flask cultures with semi-continuous feeding and packed bed, fixed bed, fluidised bed and stirred tank cultures with continuous perfusion of culture medium. Of these the fixed bed bioreactor had the highest cell specific productivity and was capable of running for 28 days. The fluidised bed bioreactor had the highest reactor productivity, due to the higher cell number.

Optimisation of culture medium was performed with regard to serum concentration. The greatest production was observed at an initial serum concentration of 2.5% (v/v). The findings in this thesis will assist the development of an efficient method for the production of clinical grade retro viral vectors for gene therapy applications.


The present work deals with the ecophysiological studies on the biochemical contents of the effect of copper and zinc on Sesuvium portulacastrum L. The Sesuvium portulacastrum plant are grown in pots in a spilt plot design with copper and zinc concentration levels as main treatments (control, 100, 200, 300, 400, 500 and 600 mg/kg -1 ). The experiments were replicated five times. The Sesuvium portulacastrum plants are raised in pots. The copper and zinc were mixed with (1:2) the sand and applied to the pot soil (10 kg /acre). The two heavy metals copper and zinc were applied in the soil mixed. Pots were irrigated as and when necessary. The plant samples were analyzed at four different intervals (30, 60, 90 and 120 th DAS). The results indicates that the heavy metals (copper and zinc) application, at the six rates (100, 200, 300, 400, 500 and 600 mg kg -1 ) caused reduction in various biochemical contents such as (Amino acid, Proline, Protein, Total sugar and Starch) when applied copper and zinc. Increasing in various bio chemical contents such as (Amino acid, Proline, Protein, Total Sugar and Starch) copper 200 mg kg -1 , zinc 300 mg kg -1 only increased low concentration and higher concentration is decreased the all biochemical contents Sesuvium portulacastrum.


In this paper, we try to establish new technique that the components of the biological clock are reconstituted into the liposome. In other words, we try to produce a nano size clock, capsulated into the liposome, made by protein molecules. The circadian clock is a basic cellular system found in almost all organisms. This clock generates self-sustained oscillations under constant conditions with a ≈ 24-hour (circadian) period. In cyanobacteria, circadian clock could be reconstituted in vitro only by mixing the three clock proteins, KaiA, KaiB, KaiC, with adenosine triphosphate (ATP). So we reconstitute these proteins and adenosine triphosphate (ATP) into phospholipid-coated microdroplet and confirmed the clock function. The clocks in phospholipids-coated microdroplet indicate long period more than 24 hours. In this case, period length became 35 hour, self-sustaining oscillation was reaming with little dumping. To reveal why the time cycle became long period, we observed localization of Kai proteins in phospholipid-coated microdroplets by using fluorescents labeled Kai proteins under fluorescent (confocal) microscopy. From the observation of localization of Kai proteins, we found KaiB protein was distributed equivalently, on the other hand, KaiC protein was located near membrane of phospholipid-coated microdroplet. These results indicate that different localization between Kai proteins cause long period oscillation and we could control period length depend on calculation data from localization.


Through Morrey's spaces (plus Zorko's spaces) and their potentials/capacities as well as Hausdorff contents/dimensions, this paper estimates the singular sets of nonlinear elliptic systems of the even-ordered Meyers-Elcrat type and a class of quadratic functionals inducing harmonic maps.


The idea of the Lehmann Symposia as platforms to encourage a revival of interest in fundamental questions in theoretical statistics, while keeping in focus issues that arise in contemporary interdisciplinary cutting-edge scientific problems, developed during a conversation that I had with Victor Perez Abreu during one of my visits to Centro de Investigaci\'{o}n en Matem\'{a}ticas (CIMAT) in Guanajuato, Mexico. Our goal was and has been to showcase relevant theoretical work to encourage young researchers and students to engage in such work. The First Lehmann Symposium on Optimality took place in May of 2002 at Centro de Investigaci\'{o}n en Matem\'{a}ticas in Guanajuato, Mexico. A brief account of the Symposium has appeared in Vol. 44 of the Institute of Mathematical Statistics series of Lecture Notes and Monographs. The volume also contains several works presented during the First Lehmann Symposium. All papers were refereed. The program and a picture of the participants can be found on-line at the website this http URL


Background: With the development of genetic research in oncology, it has become possible to track and identify early and preclinical forms of hereditary oncological diseases, which allows timely and effective preventive and therapeutic measures in relation to relatives at risk.

Aim of the study: Assessment of genetically determined neoplasms in the region and the development of organizational forms and methods for early diagnosis.

Material and methods: 10,727 residents of the Belarus-Poland border region were examined. Clinical and medical history data of 2,054 patients with tumors of the breast (1406), ovaries (239), and colon (409) were analyzed. As a result of the questionnaire, three main observation groups were formed: "high risk of hereditary cancer", "hereditary cancer suspected", and "no risk of hereditary cancer".

Results: Register and hospital screenings were the most informative types of screening. Of the 149 HBC patients who underwent molecular genetic testing, BRCA1 gene mutations were found in 5.37%, 5382insC in all cases. Seven mutations were detected in 77 individuals with a diagnosis of HOC and in 6 cases 5382insC and in 2 - 4145delA. Signs of hereditary ovarian cancer and suspicion of it were found in 1.12%, including people who were found to have a high risk of hereditary ovarian cancer. By their effectiveness, register and hospital screenings significantly exceeded the population, p<0.01. 1.67% of women suffering from this disease met the high clinical risk criteria for hereditary ovarian cancer. A high clinical risk of hereditary tumor genesis was established in 0.73% of cases among patients with a diagnosis of colon cancer.

Conclusions: The results of assessing the clinical risk of hereditary cancer according to population screening indicates that approximately 1.2% of the population has an increased clinical risk of developing hereditary breast, ovarian, and colon cancer.


The advent of new media has posed a challenge to conventional media. Their effect, for example, is felt on the circulation of print newspapers, especially in the USA. However in Malaysia, the effect of the new media on conventional media is still manageable. Malaysian newspapers still attract advertising dollars even with the presence of online newspapers. The two reinforce each other. Thus, in this paper, we argue that the presence of the Internet will not replace newspapers, just as radio did not replace newspapers and television. This paper will look at the present situation of conventional media, especially print newspapers vis-a-vis. the new media in Malaysia. We believe that the layout of newspapers here may change, but the content is still in the form of news. Even though the conventional media have their own online versions, they have not fully embraced the new technology. Even if there is a drop in circulation, it would be because the younger generation prefer the new media as they are more interactive compared to the online version of mainstream. There are also television stations which have an online presence such as TV3 and its owner, Media Prima. A large number of Malaysian citizens have their own Internet connections, so they can read newspapers online, thus squeezing revenues from advertising especially at a time of global economic slowdown. In Malaysia, however, the new media and conventional media will continue to coexist and reinforce each other.


e11509 Background: HER2 targeted therapies are effective treatment for breast tumors that overexpress the HER2 protein to a high level (IHC score of 3+) or have amplification of the HER2 gene (HER2/CEP17 >2). However, the majority of breast tumors exhibit low to intermediate expression of HER2 (IHC 1+ and 2+), for which there are limited treatment options. A new cancer vaccine candidate, E75 or nelipepimut-S, offers prevention of reoccurrence in these patients by generating a specific immune response to a HER2 peptide. To date, no companion diagnostic test is validated to differentiate HER2 at these levels of expression. The BOND Oracle HER2 IHC assay (Leica Biosystems) is being validated to reliably identify IHC HER2 1+ and 2+ cases by correlating to independent analytical measures of HER2 expression. Methods: Quantitative PCR was used to determine HER2 DNA copy number and mRNA expression in eight breast cancer cell lines spanning HER2 IHC scores of 0 to 3+ and 45 formalin fixed, paraffin embedded (FFPE)...


A 0.4mm2 SoC resource manager controls operating frequency and allocates data bandwidth using various monitored information such as temperature, frequency of IP blocks and number of operations executed. Results show an increase of allowable temperature range by 30degC for real-time operations of two processor cores and two media processing cores. The design is fabricated in an 8M 90nm CMOS process


This work includes "organic" composition while biologically probe for several modern heterocyclic derivatives via 3 steps: Firstly synthesis from some 5-membered. heterocyclic derivatives (Pyrazole while isoindoline-1,3-dione) from  quinoline. Secondly included characterized and confirmed by using melting point, TLC, infrared spectrum analysis while1H-NMR. Thirdly ncluded the examination of biological activity of some components against (4) varieties of pathogen bacteria (Staphylococcus aureus, Staphylococcus epidermidis) gram-positive and (Escherichia coli,  Klebsiella sp.) gram-negative and fungal infections (Candida albicans). The results of whole derivatives show stellar biological activity compared to antibiotics (gentamycin).


In his long career, Whitehead was, variously, a mathematician, speculative physicist, historian of science, philosopher of science, and philosopher in his own right. As such, he occupies a perhaps unique place within recent western thought. Not only did he advance scientific thought, he also developed a novel, systematic philosophical understanding of science based on a deep historical appreciation of both its theoretical premises and its practical procedures. Whitehead did not dismiss science, he did not see it as divorced from philosophy, nor did he accept the premises which, he maintained, still inform much of modern science. One of Whitehead's great achievements, which will be taken up later in this paper, is his insistence that science, philosophy, the humanities, and social theory all require a renewed conception of nature (in the broadest sense of the word), one which goes beyond strict scientific limitations, beyond any form of biological essentialism or reliance upon some notion of the ultimate laws of physics or nature. Through his philosophy of organism, Whitehead aims to develop a concept of nature that is able to incorporate all existence, thereby bringing together the empirical, the material, the social, the aesthetic, and thinking beings.