It has long been the goal of computational neuroscientists to understand and harness the parallelcomputational power of the mammalian nervous system. However, the vast complexity of such a nervoussystem has made it very difficult to fully understand even the most basic of functions such as movement andlearning and accordingly there has been increasing attention paid to the development of emulations ofsimpler systems. One such system is the C. elegans nematode, which has been widely studied in recentyears and there now exists a vast wealth of biological knowledge about its nervous structure, function andconnectivity. The Si elegans EU FP7 project aims to develop a Hardware Neural Network (HNN) toaccurately replicate the C. elegans nervous system behaviour to enable neuroscientists to better understandthese basic functions. To fully replicate the C. elegans biological system requires powerful computingtechnologies, based on parallel processing, for real-time computation and therefore will use FieldProgrammable Gate Arrays (FPGAs) to achieve this. In this paper an overview of the complete hardwaresystem required to fully realise Si elegans is presented along with an early small scale implementation of thehardware system.


[Objective]To find out the outbreak reason and cause of disease of acute gastroenteritis.[Methods]Carried on inquisition,sampling and inspection to investigate the case and personnel working in the canteen,and carried out the field survey sampling and inspection to check the canteen and the food processing process,environmental hygiene and water quality. Used the method of case control to survey risk factors.[Results]87 people fell ill,attack rate 6.6%. A food employee and 7 sufferers were detected out the Shigella flexneri Ⅳ. Having meals in canteen was the risk factor of outbreak,the OR value of breakfast on the 18th day was the tallest(OR95%CI = 3.38-19.87),outbreak and times of taking meals had a dose response relationship(χ2 = 18.99,P﹤0.05).[Conclusion]The outbreak is induced by bacillary dysentery,the reason is that the employees working in canteen contaminate food. Supervision and management on food hygiene should be strengthen,training of personnel on health information should be enhanced.


A mid-infrared (MIR) biochemical sensor based on a one-time Si etching suspended microracetrack resonator with lateral subwavelength-grating metamaterial cladding is theoretically and experimentally demonstrated on a commercial 340-nm-thick-top-silicon silicon-on-insulator platform. The suspended structure offers an increased interaction area between the mode field and the chemicals under investigation, as well as good sensitivity. The one-time Si etching process also eases the fabrication. The suspended waveguide is optimized to obtain a balance between propagation loss and sensitivity. The suspended microracetrack resonator is experimentally measured at 2 μm wavelength with an extinction ratio of 12.1 dB and a full-width at half-maximum of 0.13 nm, which corresponds to a quality factor (Q factor) of 15 300. With the equivalent refractive index method and a specially developed numerical model, the sensing performance based on the waveguide structure has been simulated and analyzed. The simulation results show that the expected sensitivity of fundamental TE mode can achieve 337.5 nm/RIU. This one-time Si etching suspended microracetrack resonator shows great potential for ultrasensitive MIR optical biochemical sensing applications.


The place and role of the legislature or Parliament in New Zealand's law-making process is discussed. New Zealand's Parliament has the ability to create and change the law on a virtually unrestricted basis; however, does require some degree of reform, some of which are highlighted.


Blowup in finite time for nonlinear Schrodinger equations (NLS) with inverse-square potential a|x| −2 and nonlocal nonlinearities described by integral operators (HE)a is consid- ered. The local and global existence for (HE)a is studied in Suzuki(10). To show the blowup for (NLS) the virial identity is important role. But the identity for (HE)a has not proved in consequence of the strongly singular potential. Thus we give a strict proof of the virial identity for (HE)a.


A family of polymers [Ln2(ad)(Had)2(NO3)2(H2L)2(H2O)2]·2H2O (Ln = Nd (1), Sm (2), Eu (3)) and [Ln(ad)(H2L)(H2O)2]·NO3·2H2O (Ln = Gd (4), Tb (5), Dy (6)) was synthesized. The polymers were characterized by powder X-ray diffraction (PXRD), infrared spectra (IR), single-crystal X-ray diffraction, thermogravimetric analysis (TG), and elemental analysis (C, H, N). On the basis of the luminescence properties of the polymers, we used polymer 5 as an example to detect thiamines (TPP, TMP, TCl). In the way that was expected, polymer 5 could quickly detect TPP, TMP, and TCl, which could be used as a typical luminescence sensing material in the field of optical detection.


Dermatologists should note that a new contact allergen is becoming a more prevalent cause of irritation as it is now found more frequently in personal care and laundry products, which are resulting in a greater number of contact allergies now than fragrances and dyes.


We report an unusual case of lupus panniculitis or Kaposi-Irgang disease, of difficult diagnosis. A 40-year-old woman without particular pathological history had consulted in the Service of Dermatology of the Departemental CHU Borgou/Alibori for nodular and painful lesions of the trunk and the thoracic members having begun in the right breast and evolved for eight continuous months. The dermatological examination discovered on the trunk and the thoracic members, nodular hurts under an erythema skin, painful at the palpation; of diameters varying between one and five centimeters. Anatomical examination and immunohistochemistry helped to retain the diagnosis of lupus panniculitis and the patient was given Prednisone orally in degressive doses. Skin lesions regressed after three months. Anatomicalclinical confrontation is essential to retain a positive diagnosis of rare skin diseases such as panniculitis lupus.


The use of cement-bonded agglomerates of iron-rich by-products generated in iron and steel plants as burden material for blast furnaces is becoming quite common. It has been observed that under cer ...


Much research has been conducted into the visualisation of objective space and decision space landscapes. This work moves away from this and investigates a 3D interactive method for linking EA decisions through time with the design of engineering systems. The proposed system shows through an intuitive interface, the design space being explored by the algorithm including decision variable choices, locations that are fixed early on in the optimisation and those problem areas that are difficult for the algorithm to solve. The paper presents a case study in water distribution network design, although the methods described are, in principle, generalisable to other design domains.


A New Time Varying LMS (NTVLMS) algorithm is proposed and its performance is analysed. The proposed algorithm is applied to adaptive noise cancellation system. The investigations have indicated better performance of the proposed NTVLMS algorithm as compared to LMS, NLMS, RVSSLMS, NVSSLMS and TVLMS algorithm for stationary signal in terms convergence rate and output SNR except MVSSLMS algorithm. For Speech signals proposed NTVLMS algorithm is better compared to other algorithms in White Gaussian noise Environment and NLMS algorithm performs well in Conference noise, Engine noise & Traffic noise environments in terms of output SNR.


The Government of Canada is investing $4.6-million in Integran Technologies Inc. of Toronto, Ontario, for the research and development (R&D) of next-generation nanotechnology-based coatings for the Joint Strike Fighter (JSF) program.


Lately, creative industries have become an extremely popular concept in cultural policies across the globe. For many, it came as a surprise. However, the idea of merging culture and arts with industrial production has been slowly evolv ing during the 20 th century, thus there is not much space for a surprise. The aim of this paper is to position creative industries in a broader historical and theoretical framework. The paper is looking at the interplay of popular culture and public (cultural) policies: from the post-war critical theory of the Frankfurt school and UNESCO's early debate on cultural industries to the recent policies and theories on creative economy and creative industries.


Reviewed by Amos YongFuller Theological SeminaryE-mail: email@example.com one sense, this book is overdue, but in another, it's just the beginning of a predictable torrent expected to follow on...


Eco-engineering techniques involve the use of both plants and inert materials where, in the latter, nontreated wood is usually present. The two different elements will both evolve with time and change their mechanical properties differently. On one hand, the wood will degrade decreasing its effective cross sectional area with time. On the other hand, the live plant material will grow and propagate new roots as time progresses. Both root development and inert material changes must be accounted for in order to realistically simulate a bioengineered slope evolution and design effective eco-engineering solutions. The dynamic nature of a bioengineered work sets different scenarios throughout the slope design life. All these different stages must be taken into account in the work design process. In this work, we propose an adaptation of the existing routines and procedures of both geotechnical practice and civil engineering design scheme in order to closely reflect the inclusion of bioengineering methods in the classic geotechnical engineering problems. A design methodology covering different critical points within urability the lifecycle of a bioengineered slope is proposed and put into practice into the design stage for a case study in Scotland. By detecting critical points at the design stage the proposed methodology was proven to offer an improved eco-engineering work design scheme. With the use of the proposed method both external and internal stability checks with their corresponding safety factor values increase with time and there are no conflicts between the two evolving processes involved in this kind of works. © 2016 Elsevier B.V. All rights reserved.


An Efficient and effective image segmentation is an important task in image processing and object recognition. Since fully automatic image segmentation is usually very hard for natural images, interactive schemes with a human interaction provide us good solutions. If we want to retrieve the particular selected area of any object for any special purpose like quality of the image or any security purpose, we need to select the pixels of the image and retrieve the particular object. This paper presents a new region merging based on fuzzy flood fill method. The users only need to roughly indicate the location and region of the object and background by using strokes, after that use fuzzy flood fill to extraction of object. A region merging mechanism is proposed to guide the merging process with the help of initial segmented image. A region is merged with its adjacent region if they have good similarity among them, here good is fuzzy variable. The proposed method is merging the initially segmented regions and then effectively extracts the object contour. The region merging process is the image content and it does not need to set the similarity threshold in advance, but it based on some fuzzy variables e.g. low, medium, high similarity etc.


High impedance surfaces formed by parallel wires are placed above a finite conductivity surface and used to enhance the radiation from low profile horizontal dipoles. The simplest is a single wire directly beneath the dipole. For the case considered the dipole is λ/100 above ground with a single parasitic wire λ/1000 above ground. PEC antenna conductors were used to investigate only ground losses. Surprisingly, the single parasitic wire increases zenith gain over a wide range of lengths. At the optimum length the zenith gain is increased by 8.8 dB. A second example using 3 parasitic wires gave a gain increase of 13.4 dB. For both cases the input resistance is low indicating that the real increase in gain may be limited by the finite conductivity of practical antenna conductors.


Monte Carlo simulations of the lamellar phase transitions for symmetric amphiphilic chains are carried out on a cubic lattice, with the amphiphilic chain length N as large as 192 lattice sites, corresponding to lengths typical of those in experimental systems. We find that there is a qualitative change in the orderdisorder transition when N exceeds about 50. For N≤ 50, the compositional order parameter S at the transition is large; S ≃ 0.8 on the ordered side of the transition. For N≥ 50, the jump is more modest, around 0.50 or less


Scientific small satellite missions for remote sensing with Synthetic Aperture Radar (SAR) payloads or high accuracy optical sensors, pose very strict requirements on the accuracy of the reconstructed satellite positions, velocities and accelerations. Today usual GPS receivers can fulfill the accuracy requirements of this missions in most cases, but for low-cost-missions the decision for a appropriate satellite hardware has to take into account not only the reachable quality of data but also the costs. In this paper an analysis is carried out in order to assess which on board and ground equipment, which type of GPS data and processing methods are most appropriate to minimize mission costs and full satisfying mission payload requirements focusing the attention on a SAR payload.


Active eutectic brazing alloys based on certain refractory metals are produced by melting in vacuum arc or electron-beam systems with subsequent rolling of ingots into foil or by electroplating of components on titanium foil. A large number of promising brazing alloys can be produced by conventional methods because of the high hardness and brittleness of alloys or because of the need for vacuum welding sheets of refractory metals produced by hot rolling. In this work, the authors propose a technology of producing active multicomponent brazing alloys of the Ti-Nb-V, Zr-Ti-V-Fe and V-Pd-Nb, Cu-Ni-V-Ti-Zr and Fe-V-Nb systems, including explosion welding the components of the brazing alloy with the production of multilayer blanks with high strength of the joints in the layers, cold rolling of the blanks to the design thickness with intermediate 'softening' heat treatment, and subsequent diffusion annealing for equalising the chemical composition in the thickness of the brazing alloy. To decrease the nonuniformity of layer deformation and minimise the deflection of welded and rolled sheets, investigations were carried out using a symmetric system of composition of the packets. The initial thickness of the sheets-components was calculated taking into account the required chemical composition of the brazing alloy, density and dimensions of the refractory elements used. The thickness of the interlayers was varied from 0.1 to 3.0 mm, and the thickness of the welded packets from 3.4 to 11 mm. The optimum welding conditions and absence of 'dangerous' heterogeneities in the form of brittle intermetallic and chemical compounds at the layer boundaries was ensured by rational alternation of the layers of the metals taking into account their initial thickness. In particular, it was taken into account that Ti with V and Zr, and also V with Fe and Nb form a continuous series of solid solutions. The alloys of the Cu-V system are characterised only by the formation of limited solid solutions with low hardness, high-strength and ductility. The compounds of Cu and Ni with Ti, Nb with Pd and Fe are characterised by the limited initial solubility and form, at specific concentrations, intermetallic compounds with high hardness and brittleness. The hardness of the intermetallic compounds of the elements with similar chemical properties (Fe-Nb) is slightly lower at a specific ductility. Removal of the powerful effect on the intermetallic compounds was achieved by selecting the optimum conditions of welding and using equipment with a given rigidity. Examples of the distribution of layers in the explosion-welded multilayer blanks of the brazing alloys are presented in Fig. 1. In the conventional methods of welding multilayered packets of metals and alloys with a thickness smaller than 1 mm, welded joints often contain defects in the form of bubbles, lack of fusion and fracture of the upper layers. To protect against the nonstationary nature of detonation of the explosive substance (ES) and perturbations in the explosion products, experiments were carried out with the method of explosion with a false flyer plate with a thickness of 4-5 mm, coated with a consistent lubricant for preventing its welding to the protected thin metal. Calculation of the optimum parameters of simultaneous explosion welding of the multilayered packets was carried out by the standard method in a computer using Welding software taking into account physical-mechanical characteristics of welded materials. The explosive substance was a mixture of 30% ammonite and + 70% of salt peter, the detonation speed of the mixture was D = 2600 m/sec. The results of external examination, the bend test and metallographic examination of the welded packets showed satisfactory quality of the joints and the interlayer boundaries. As indicated by Fig. 2, after explosion welding, the weld zone shows maximum hardening of the metals and with increase in the distance from the interphase the hardness rapidly decreases but is still higher


The premiere of Debussy's Pelléas et Mélisande in late April 1902 occasioned a maelstrom of critical responses in the Parisian press—more than a hundred reviews over the course of a few months and eighty-eight in the month of May alone. A flashpoint of French modernism, the Pelléas premiere catalyzed a rethinking of the nature of music in this critical discourse, as prominent critics, such as Pierre Lalo and Robert Godet, shifted their account of music away from the Revue wagnérienne's exclusive focus on sentiment and interiority and toward an aesthetics of noise, materiality, and outer sensation. While it was not uncommon for critics to compare the music of Pelléas to Impressionist painting or Symbolist poetry, such comparisons only served to highlight an overriding preoccupation with a specifically musical problem: how to negotiate the demands of musical convention and historicity against the nature of music as material sound.


The moral of this story? Where there's smoke, there's a good chance you'll find fire. That's the precautionary principle practiced by most governments in Europe when it comes to protecting public health from the 4.2 billion cell phones in the world and the electromagnetic radiation they emit. Refusing to adhere to this "better safe than sorry" principle has caused catastrophic health and environmental effects globally, writes David Gee, an editor of The Precautionary Principle in the 20th Century: Late Lessons From Early Warnings. The book analyzes the dismal failures of governments around the world to respond to early danger signs in the environment, from rising levels of carcinogens to the depletion of Atlantic fisheries. In February 2009, Gee testified in Brussels at a European Commission workshop on electromagnetic fields (EMFs) and health. He warned about the profound danger posed by cell phone radiation—also called electropollution—which many scientists are now calling the "worst toxin in planetary history."


The traditional research of image-based rendering mainly focuses on static scene rendering, however, the result of rendering scene is unsatisfying when there is movement object such as flowing water or the swing of the pendulum, and so on. Recently, rendering dynamic scene is becoming a new highlight on image-based rendering research. The basic concept and all sorts of method on image-based rendering were lucubrated. The development of the research, potential problems and disadvantage on the technology of rendering dynamic scene were discussed, and an outlook to future research was concluded with at last.


The competition in Chinese manufacture has intensified in recent years, partly due to the economic transition and the international competitiveness improvement. To cope with this challenge, it is important for Chinese manufacture to provide service provision which is conceptualized as servitization. The servitization of manufacture is responded by innovating and creating products and services that meet customers' needs. This paper provide a perspective on the nature of service infusion in manufacturing companies based on a case analysis in the context of a solution for Sinosteel Xingtai Machinery & Mill Roll Co., Ltd. A new paradigm of servitization that has the potential to minimize the price competition of mill roll industry is emerging. The mill roll maker has implemented the new servitization paradigm called "function pricing" which realized the transformation for service supplier. The servitization of the mill roll maker shows the innovation capabilities of the transition from selling products to selling integrated products and services. This case presents that the company with significant manufacturing capabilities possesses the advantage of integration between manufacturing and service. The main finding is that the successful servitization of manufacturing requires advanced technology, human resources and organization layouts, in order to get economic benefits. The mill roll maker benefits for the innovation, encouraging the optimum development of the enterprise. Therefore, the transformation of manufacturing is a concept of significant potential value, providing routes for them to exploit higher value business activities.


The sharp increase in petroleum prices beginning in mid-1999 and experiences with tighter supply, has renewed concern about our dependence on petroleum imports. One of the strategies for reducing this dependence is to provide vehicles that run on alternative to gasoline and diesel fuel. These alternatives include alcohols, gaseous fuels, renewable fuels electricity and fuels derived from coal. The push to develop alternative fuels, although driven by energy security concerns, has been aided by concerns over the environment, because many alternative fuels lead to reduction in emissions of toxic chemicals, ozone-forming compounds and other pollutants, as well as the greenhouse effect. This new book explores the energy and environmental issues, and how they affect the regulatory attempts with regard to transportation fuels. Also, the tax treatment of alternative transportation is analysed.


Development of textbook such as handout development is mostly done as support for learning. the development of handout is done with the purpose of completing the tekstbook so that student are able to understand the learning material well besides the development of handout done to add informasion. But in the development of handouts it is necessary to analyze the validity of handouts used in the lesson. This research that purpose to analyze the level of validity to the development of problem based handout on environmental pollution chapter class VII SMP/MTs through validity test. The problem based handout validity test in done by the material expert and media expert from the validation result gets the percentage value based on the aspect of the contect of 80,95%, the material presentation is 83,34%, the readability aspect is 83,34% and the aspect of the problem presentation is 81,67%. Overall validity test result obtained a percentage value 82,33% with valid criteria. based on validity test result analysis of handouts developed it has been valid for use in learning.


Hydrocephalus is considered to be one of the diseases that may cause damage in children brain especially infants. MRI (Magnetic resonance Imaging) is one source of hydrocephalus detection tools, but using MRI in children brain diseases classification is considered to be difficult process according to the variance and complexity of brain diseases. This paper presents a solution of detecting one of the children brain diseases which is hydrocephalus. The proposed system consists of four stages, namely, MRI Preprocessing stage, Segmentation stage, Feature extraction, and Classification stage. In the first stage, the main task is to eliminate the medical resonance images (MRI) noise found in images due to light reflections or operator performance which may cause inaccuracies in the classification process. The second stage, which is the stage where ROI is extracted (tumor region). In the third stage, the features related with MRI images using Haar wavelet transform (HWT) will be obtained. The features of magnetic resonance images (MRI) have been decreased using (HWT) to essential features only. And finally the fourth stages, where new classifier will be presented and finally the result will compare the proposed classifier with six other classifiers have been used. Image classification is an important task in the medical field and computer vision. Image classification refers to the process of labeling images into one of a number of predefined categories. This survey will use the Tree augmented Naive Bayes classification technique to detect and classify one of the children brain diseases, and classify the hydrocephalus type depending on MRI. And it's expected to achieve a high accuracy in hydrocephalus detection to help the radiologist in the disease detection process.


This paper is devoted to the publication of materials obtained during the study of the burial of the early Middle Ages in the burial mound Maslennikovo I. This necropolis is located in the steppe southwestern part of the Samara Trans-Volga region. The excavated mound 1 was built in the Bronze Age in the process of making eight burials of this time. Burial 2, admitted into the floor of the embankment in its southern part, dates back to the Middle Ages. The burial was made in a grave pit in the shape of an elongated oval and oriented with its long axis along the NW-SE line. The buried man lay stretched out on his back with his head to the northwest. The bone of a horses leg lay at his head. Gold foil fragments, which may have been the remains of a symbolic death mask, and earrings were also found in the area of the head. The remains of a wooden object with silver plates at the edges, probably of a quiver on the chest of a deceased burial were found. The remains of a scabbard, which also had silver plates there were in the region of the pelvis and between the thigh bones. Seven silver sewn-on plaques with embossed ornaments and several poorly preserved iron objects were found in the grave. The peculiarities of the funeral rite and accompanying implements make it possible to include this complex in the number of burials attributed by researchers as Magyar (proto-Magyar, Hungarian) and to consider it as the burial of an individual integrated into the ethnocultural environment of the Hungarians of the Middle Volga region of the 9th-10th centuries.


In this paper we analyse the relationship between long bond yields and inflation in an economy subject to three types of stochastic disturbances: real shocks, nominal shocks, and shocks to term premia. Statistical inference is based on the impulse-response function of a Structural VAR model, where appropriate long-run identifying restrictions are derived from economic theory. Using data for the U.S. over the past 45 years, we find that long bond yields and inflation move one-for-one both in the medium term and in the long term when the economy is subject to real or nominal shocks. However, the predictive power of long bond yields for future inflation breaks down when bond yields are driven by changes in term premia. Given that term premia are related to interest rate volatility, our results help explain the negative correlation between long bond yields and inflation during the 1980s, when interest rate volatility climbed to historical peaks.


Reaction of phenols with 2-(isopropylthio)ethyl acetate activated by sulphuryl chloride afforded 2-[2-acetoxy-1-(isopropylthio)ethyl]phenols regioselectively, via[2,3]sigmatropic rearrangement of phenoxysulphonium ylides. The ortho-alkylated phenols thus obtained have been cyclized with conc. hydrochloric acid in 2-methoxyethanol to 1-benzofurans. 2-Methyl- and 2-phenyl-1-benzofurans have been prepared similarly.


To explore the efficacy of antibiotic bone cement (ABC) combined with the modified tibial transverse transport (mTTT) on the treatment of severe diabetic foot with infection.


This study explores the influence of the social network of board interlocks on the creation of strategic alliances between firms. Our theoretical framework introduces the notion that board interlock ties may be heterogeneous, depending on the nature of the CEO/board relationship that underlies the tie, and examines how the influence of such ties could have either a positive or negative influence on alliance formation. The role of both direct interlocks between firms and indirect third-party ties in interlocking directorate networks were examined with a unique dataset that combines extensive archival data on board interlocks and strategic alliances with primary survey data on management-board relationships from a large sample of top managers and outside directors. We found that board interlock ties to other firms can either increase or decrease the likelihood of alliance formation, depending on the content of the particular relationships that exist between CEOs and outside directors (who serve as CEOs at other firms). CEO/board relationships characterized by independent board control appear to reduce the likelihood of alliance formation by prompting distrust between corporate leaders, while CEO/board cooperation in strategic decision making appears to promote alliance formation by enhancing trust in the relationship. The effect of direct interlock ties are further amplified by the third-party interlock ties in which they are situated. Implications of these findings for the literatures on social networks, corporate governance, and board interlocks are discussed.


Primary Health Care facilities provide promotive, preventive, curative and rehabilitative services to a community. They may be well built and equipped with adequate resources but grossly underutilized due to several factors. Health records at the Comprehensive Health Centre Gindiri for 2005 were compared with those of 2007 after a wellcoordinated advocacy and mobilization programme in that community. The results show that the total out patient attendance in 2007 increased by 220.6% when compared to that of 2005. 293 patients were admitted into the wards in 2005 compared to 813 in 2007(277%). There was no surgery carried out in the whole of 2005, whereas in 2007 there were 98 surgeries. Advocacy and community mobilization could be important factors in the utilization of primary health services


Objective: To explore the influence of chromosome abnormality on reproduction and the change of the types and distribution of abnormal karyotype in spontaneous abortion couples in recent 30 years. Methods: The chromosome karyotype data from 1982 to 2011 of 651 couples( 1302 cases) with spontaneous abortion history were analyzed retrospectively,using peripheral blood lymphocyte culture-G banding method. Results: Among 1302 cases,we found chromosome aberration in 41 cases( 3. 15%) and chromosome heteromorphisms in 148 cases( 11. 37%),so the total chromosome abnormality rate was 14. 52%. Then we compared the data every 10 years. Compared with 1992-2001,the chromosome aberration rate of 2002-2011 increased( P 0. 05); Compared with the 1982-1991,chromosome anomaly detection rates of 1992-2001 and 2002-2011 were higher( P 0. 05). Conclusion: In the population with spontaneous abortion,chromosome abnormality rate is high and has increased in recent years.


It is provided with a power supply, an articulated arm coordinate measuring machine having a plurality of power sources. The power supply has an input configured to receive electrical power from an external power supply, and first and second energy storage elements. The first energy storing element has to measure a first processing circuit which is configured to at least a first parameter and to transmit a first signal to the first electronic circuit. The second energy storage element has a second processing circuit which is configured to measure at least a second parameter, and to send a second signal to the first electronic circuit. The power supply is configured to transmit electrical power selectively from at least one of the first and second energy storage elements, wherein the power supply is further configured for the transmission of electrical power from the first and second energy storage elements in response to the first signal and the second signal switch.


Aim To investigate optic nerve function using the pattern-reversed visual evoked cortical potentials (VECP) before and after bony orbital decompression in dysthyroid optic neuropathy (DON) due to Graves' disease. Methods A total of 30 eyes of 15 patients (n=14 female) were observed over 30±13 months after bony three-wall orbital decompression. We examined visual acuity (VA), VECP P100 amplitudes and latencies, as well as proptosis using Hertel's exophthalmometry. Results Mean logarithm of the minimum angle of resolution (logMAR) VA increased, statistically significantly, by 2.4 lines during 30±13 months (from 0.38±0.25 before surgery to 0.14±0.1 at the end of observation, p=0.0001). All eyes maintained or improved vision by at least one line. Mean postoperative reduction of proptosis was 6.4±3 mm. While VECP P100 amplitudes improved significantly, P100 latencies remained abnormal in 18 eyes (60%) during follow-up of 10±7 months. Nine eyes (30%) with previous latency defects improved in at least one check test, five of which normalised completely. Worsening was evident in seven eyes (23%), and three previously normal eyes developed new pathological latencies. P100 latencies in 14 eyes (47%) remained unchanged. Conclusion After decompression surgery, DON remission was observed in all patients regarding vision and VECP amplitudes. New or persistent P100 latency defects were seen in 60% of eyes after surgery. DON is considered to be caused by compressive ischaemic damage, which further underlines the importance of early decompression surgery.


In this paper, we show how the optimal setting of an ensemble-based lesion detector can improve the performance of the system. That is, instead of the individually optimal parameter settings of the member algorithms, we determine such a setting that maximizes the accuracy of the ensemble. Our case study is an ensemble composed for microaneurysm detection on retinal images that is currently ranked as first in an online competition. The determination of the optimal parameter setting is a very time consuming problem, especially in fusion-based systems. Thus, we suggest several speedups in a stochastic optimum search framework regarding the evaluation of the corresponding special energy function. In other words, we also suggest some modifications and tuning of stochastic search approaches for ensemble-based image detectors evaluated on test databases.


The utility model relates to a flameproof vacuum feeding switch for coal mine usage, including a switch shell, an incoming and outgoing wires pipe socket, buttons and display windows. A vacuum circuit breaker, a transformer and a protector are mounted in the shell. The protector has selective leakage protection circuit, leakage lockout circuit, overloading, short-circuited protection circuit, overpressure, low-voltage protection circuit, display circuit and tripping and close-break control circuit. The three-phase power connects with vacuum circuit breaker, wherein, one connects with the leakage lockout circuit in the protector, one connects with overloading through current transformer and zero sequence transformer and connects with leakage test circuit on the side of overloading. Current transformer connects with the overloading and short-circuited protection circuit in the protector. The zero sequence transformer connects with the selective leakage protection circuit in the protector. The three-phase power supply provides the transformer with electricity and the transformer outputs power supply to the protector. By using the utility model, when the protector detects outside fault signal, relative protection action could be executed after circuit processing and the fault type could be determined and sent to the monitor. Thereby, it is convenient for the operator to impair according to the fault type.


A Computational Fluid Dynamics (CFD) analysis of two-phase flow was used to obtain the distribution of lubricant in a journal bearing, including inlet tube and groove. It was found that for an incomplete starting film, the oil spread-length varies along the groove depth and film thickness. The magnitude of variation was found to be independent of the inlet mass flow rate. Numerical simulations of the proposed model show that in the cavitation region the streamlets do not fill the entire film thickness. The present numerical model agrees with experimental observations.


A thin film of BiFeO3 (BFO) was fabricated on an FTO/glass substrate using the sol-gel method and applying a sequential layered deposition process. The raw materials used in the starting solution were bismuth nitrate pentahydrate (Bi(NO3)3·5H2O), iron(III) nitrate nonahydrate (Fe(NO3)3·9H2O), and ethylene glycol (HOCH2CH2OH) as solvent. A 5 mol% excess of bismuth was used to compensate for its volatility during high-temperature annealing. Structural analysis by High-Resolution X-Ray Diffraction and Raman Spectroscopy indicated that the film exhibits a rhombohedral distorted perovskite structure without impure phases. Raman spectroscopic analysis showed 13 Raman phonon active modes (4A1 + 9E) corresponding to the rhombohedral structure R3c. The morphological study using Scanning Electron Microscopy (SEM) revealed a surface formed by agglomerations of grains with a certain degree of porosity. The thickness of the BFO film obtained from the cross-sectional image indicated an approximate thickness of 555 nm. Analysis of XPS spectra revealed the coexistence of Fe2+/Fe3+ ions in the film. The optical study showed that the film has a maximum transmittance of 66% in the visible region. The estimated value of E_g was 2.33 eV, which is consistent with those reported for BFO thin films by other researchers. In our study, it was found that the leakage current is a consequence of oxygen vacancies induced mainly by the volatilization of Bi and the presence of Fe2+ ions.


This practice-led creative critical thesis consists of my poetry collection, Forensic Traces of Falling Sunlight, a critical commentary and a study of the marginalised Cumbrian women poets who anticipate my own creative approach.
Forensic Traces of Falling Sunlight explores the ancient woodland wetland, White Moss Common, situated between Rydal and Grasmere in Cumbria. This thesis aims to contemporise a poetic depiction of a landscape imbued with a rich literary heritage.


This study is based on data acquired by the oral history method and discusses the reflections of two generations of Jews in relation to the socialist regime in Czechoslovakia (1948–1989). The first generation is represented by people who had survived the Holocaust. The second generation is represented by the 'children of the Holocaust' (born 1945–1965). They grew up at a time when the political realm was completely dominated by theCommunist Party. Their attitudes only changed with the invasion of Czechoslovakia in August 1968. This probe suggests differences which stem from contrasting life experiences.


The optical constants of a liquid hydrocarbon such as liquid n-octane are basic material properties that may be used to evaluate their thermal radiation transfer capabilities. In this study, the ellipsometry method was used to measure the optical constants of liquid n-octane in the midinfrared wavelength range of 2.0–16.0 μm at temperatures of 20, 50, and 80°C. Experimental analyses indicate the significant effect of temperature on the refractive index, although it has little effect on the absorption index. With increasing temperature, the refractive index shows a linear decrease, and reduced density leads to weaker absorption intensities. The radiative properties of n-octane droplets, including the absorption and scattering efficiency factors of single droplets with droplet radii r = 10, 20, 50, and 100 μm and the absorption and scattering coefficients in a droplets-air system of droplet volume fractions fv = 2%, 3%, and 4%, were calculated using Mie theory. The numerical results indicate that, with increasing temperature, the absorption efficiency factor slightly decreases, and the variation trend of the scattering efficiency factor is more complicated. With increasing droplet radius, the absorption efficiency factor increases within the studied wavelength range, except for certain absorption peaks, but the scattering efficiency factor tends to decrease. While the absorption is greater, the scattering is weaker for a given droplet radius. With an increasing volume fraction of n-octane droplets, the absorption and scattering coefficients increase linearly within the studied wavelength range.


This thesis presents a performance assessment of fl ight operations in the North Atlantic Organized Track System (OTS) using the Glo ba Oceanic Model. The main contributions of the study are: a) improvements to the logic of the Global Oceanic Model; b) prediction of benefits among various aircraft sepa ration minima and operational policies to assign flights to tracks in the OTS system; and c) forecast of OTS traffic over North Atlantic from 2020 to 2040. The preliminary results show that a concept of operation with longitudinal separation mi ima of 15 nm and information of the flight cost matrix provides average fuel sav ings of 93 kilograms per flight using 2020 traffic. The fuel savings increase to 170 kilo grams per flight using traffic levels expected in the year 2040. A new operational track assignment routine is developed and it could save around 40 kilograms per flight compar ed with the current concept of operations. The study results show a shortage of capacity of th e Organized Track System in the future. The analysis shows that the OTS configu ration used today and in 2020 is unable to accommodate the traffic projected in 2040 . The analysis concludes that more tracks will be needed to maintain an acceptable lev l of service. IMPROVEMENTS TO GLOBAL OCEANIC MODEL AND PERFORMANCE ASSESSMENT OF NORTH ATLANTIC ORGARNIZED TRACK SYSTEM


A method and an apparatus for writing on a multi-layer disc are described. The occurrence of a layerr jump, due to the fact that e.g. the storage space available on a first layer is exhausted, is anticipated by monitoring the storage space available remaining. When approaching the layer jump a calibration procedure for recording on a second layer is launched, so that when the layer jump is actually taking place, recording can be resumed on the second layer with minimum delay. ® KIPO & WIPO 2007


Ten radiographically diagnosed fibrous defects of bone were assessed by three-phase bone scanning. Normal scans are obtained when the lesion is quiescent or has fully healed. Mild hyperemia and moderate bone uptake is present during the healing phase and is not significant. More intense hyperemia and a markedly positive bone scan suggest that a more active process, such as fracture or tumor, may be present.


The present work enters sociology of literature and is, to a great extent, based on empirical study. The main aim of this work is to confront scientific interpretation of the Cinderella story with an intuitive reception of the story by adults. A questionnaire serves as the main research tool and is composed of close and open questions. The questionnaire is constructed in such way that each answer corresponds to a given scientific interpretation, for example a) presents psychoanalytical views, b) is related to the feminist approach etc. Philologists and psychologists are excluded from the responding group, as the could possibly encounter Cinderella in terms of scientific approach; the author wants to receive an interpretation based mainly on creativity and intuition. In order to analyze the story, certain literature and psychological publications are used, as well as dictionaries, mainly dictionaries of symbols which are essential in reading stories. The first chapter is devoted to the theoretical part of the story. It answers questions about the definition of a story, its meaning and functions nowadays. The following chapters introduce the analysis of Cinderella in terms of achievements and empirical study of its reception. It is also an attempt of recognizing potential issues in the story which may be discovered through careful reading.


Objective: To establish a method of quantitative analysis of compound promethazine hydrochloride syrup. Methods: Convolution spectrometry was applied. Results: The linear range of this method was 3.40~4.20 μg/mL,the regression equation was Qj=0.05338c +0.01332, r =0.9997,the average recoverg was 100.0%,the RSD was 0.20%.It was proved by t test that there was no remarkable difference between this method and the absorption coefficient method.Conclusion: This method is simple,convenient and rapid.


Objective To choose the sort of patrinia having better inhibition rate of hepatocarcinoma cells and optimize it's extraction process due to the sorts of patriniaits that commonly used in Chinese herbal compound prescription for tumor are complicated and the medicine effect is difficult to guarantee. Methods Two kinds of different sorts of patrinia were selected by taking inhibition rate of human SMMC-7721 hepatocarcinoma cells and total flavonoids as indexes,and the extraction process was optimized by using orthogonal test. The correlation of the two indexes was analyzed by SPSS 17.0 software. Results The inhibition rate of Patrinia villosa was better than that of Patrinia scabiosaefolia Fisch. The consistent extracting condition was gotten by using SMMC-7721 human hepatocarcinoma cells as index and total flavonoids as index. And the best extract condition was as follows:ten times the amount 70% ethanol reflux extraction three times,each time 2 h. There was a good correlation between the two indexes. Conclusion The inhibition rate of Patrinia villosa against SMMC-7721 hepatocarcinoma cells is better than that of Patrinia scabiosaefolia Fisch through contrast on extrinsic medicine effect. The extraction process of Patrinia villosa is scientific and reasonable,which laies a foundation for its clinical use.


The purpose of this study was to determine whether immunophenotypic profiles detected by flow cytometry are useful in differentiating chronic myelomonocytic leukemia (CMML) from reactive monocytosis, and between CMML subtypes.


In recent times, inflation figures used by policy makers and investors are usually at lag one (i.e. previous month's inflation rate). The reality of the present day situation where changes in the economy increases with a high degree of uncertainty, decision of monetary policy tools requires the use of current figures of macroeconomic indicators such as inflation. This paper, therefore aims at modelling and forecasting Nigeria's inflation rate for the current period, using the Kalman filter methodology. This paper reveals that estimating the Nigerian headline inflation rate using the Kalman filter approach is more efficient than the popular Box-Jenkins ARIMA(0,1,0). The efficiency of the Kalman Filter was mainly as a result of its built in specification for updating the estimation with the latest available information. This is evident the unbiased insample estimation of the headline inflation as well as the significant result of the results of the diagnostics test. Hence, the result imply that switches in the inflation series could cause the regime of the series to shift from a linear space to a non-linear regime. Therefore, an introduction of non-linear estimation methodologies may provide a starting point for further research and development of a modified state space methodology by redefining Kalman filter transition equation and its estimation procedure..


Metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) are often associated. One of their common denominators is hypogonadism. However, testosterone supplementation is limited by concerns for potential prostatic side effects. The objective was to determine whether MetS-associated prostate alterations are prevented by testosterone supplementation. We used a previously described animal model of MetS, obtained by feeding male rabbits a high-fat diet (HFD) for 12 weeks. Subsets of HFD rabbits were treated with testosterone or with the farnesoid X receptor agonist INT-747. Rabbits fed a standard diet were used as controls. HFD-animals develop hypogonadism and all the MetS features: hyperglycemia, glucose intolerance, dyslipidemia, hypertension, and visceral obesity. In addition, HFD-animals show a prostate inflammation. Immunohistochemical analysis demonstrated that HFD-induced prostate fibrosis, hypoxia, and inflammation. Journal of Endocrinology (2012) 212, 71–84 0022–0795/12/0212–071 q 2012 Society for Endocrinology Printed in Great The mRNA expression of several proinflammatory (IL8, IL6, IL1b, and TNFa), T lymphocyte (CD4, CD8, Tbet, Gata3, and ROR gt), macrophage (TLR2, TLR4, and STAMP2), neutrophil (lactoferrin), inflammation (COX2 and RAGE), and fibrosis/myofibroblast activation (TGFb, SM22a, aSMA, RhoA, and ROCK1/ROCK2) markers was significantly increased in HFD prostate. Testosterone, as well as INT-747, treatment prevented some MetS features, although only testosterone normalized all the HFD-induced prostate alterations. Interestingly, the ratio between testosterone and estradiol plasma level retains a significant, negative, association with all the fibrosis and the majority of inflammatory markers analyzed. These data highlight that testosterone protects rabbit prostate from MetS-induced prostatic hypoxia, fibrosis, and inflammation, which can play a role toward the development/progression of BPH/LUTS. Journal of Endocrinology (2012) 212, 71–84


The now widely accepted description of the new post‐industrial society as defined by Daniel Bell clearly points to an emphasis on the provision of services rather than on the production of goods. In part this is true because improved technologies for agricultural and industrial production allow a smaller and smaller proportion of the population of the Western world to supply even the increasing demands for the food, the clothing, the shelter, and the material goods which at one time took all of our strength and all of our energies. The growing emphasis is on the provision of services—in part because having others do things for us is an indication of our growing affluence—in part because the number of potential services increases as our imagination and desires constantly stay one step ahead of what we have—and in part because increased efficiency and increased performance have also brought with them increased complexity.


To the foundation of a principally new short-term forecasting method there has been laid down a theory of surrounding us world's creation and of physical vacuum as a result of interaction of byuons - discrete objects. The definition of the byuon contains the cosmological vector-potential A_g - a novel fundamental vector constant. This theory predicts a new anisotropic interaction of nature objects with the physical vacuum. A peculiar "tap" to gain new energy (giving rise to an earthquake) are elementary particles because their masses are proportional to the modulus of some summary potential A_sum that contains potentials of all known fields. The value of A_sum cannot be larger than the modulus of A_g. In accordance with the experimental results a new force associated with A_sum ejects substance from the area of the weakened A_sum along a conical formation with the opening of 100 +- 10 and the axis directed along the vector A_sum. This vector has the following coordinates in the second equatorial coordinate system: right ascension alpha = 293 +- 10, declination delta = 36 +- 10. Nearly 100% probability of an earthquake (earthquakes of 6 points strong and more by the Richter scale) arises when in the process of the earth rotation the zenith vector of a seismically dangerous region and/or the vectorial potential of Earth's magnetic fields are in a certain way oriented relative to the vector A_g. In the work, basic models and standard mechanisms of earthquakes are briefly considered, results of processing of information on the earthquakes in the context of global spatial anisotropy caused by the existence of the vector A_g, are presented, and an analysis of them is given.


The Sinhala language is widely used on social media by using the English alphabet to represent native Sinhala words. The standard script of English language is Roman script. Hence we refer to Sinhala texts transliterated using English alphabet as Romanized-Sinhala texts. This process of representing texts of one language using the alphabet of another language is called transliteration. Over the time Sinhala Natural Language Processing (NLP) researchers have developed many systems to process native Sinhala texts. However, it is impossible to use the existing Sinhala text processing tools to process Romanized-Sinhala texts as those systems can only process Sinhala scripts. Therefore these texts need to be transliterated back using their original Sinhala scripts to be processed using existing Sinhala NLP tools. Transliterating texts backwards using their native alphabet is referred to as back-transliteration. In this study, we present a Transliteration Unit (TU) based back-transliteration system for the back-transliteration of Romanized-Sinhala texts. We also introduce a novel method for converting the Romanized-Sinhala scripts into TU sequences. The system was trained using a primary data set and evaluated using an unseen portion of the same data set as well as a secondary data set which represents texts from a different context to the primary data set. The proposed model has achieved 0.81 in BLEU score and 0.78 in METEOR score on the primary data set while achieving 0.57 in BLEU score and 0.47 in METEOR score on the secondary data set.


The ability to identify a target texture in a visual display is a basic capability of the human visual system. Traditionally, as with much psychophysical modeling in the cognitive sciences, models of texture discrimination have been fit to individual subject data. By estimating model parameters independently, this approach emphasizes individual differences, and does not model the similarities between subjects. We consider alternative assumptions about individual differences in texture discrimination, using a standard model and previously studied data. In particular, we show how a hierarchical Bayesian approach can capture both the similarities and differences over subjects in a theoretically satisfying way. We also show that the hierarchical Bayesian approach has a number of methodological advantages over existing analyses, including improving parameter estimation when data are either sparse or missing, and improving model predictions when generalizing to new or different stimuli.


Shikimic acid (3,4,5-trihydroxy-1-cyclohexene-1-carboxylic acid) is considered as an essential biochemical metabolite in autotrophic organisms, such as plants and some bacteria, which is used to procreate the anti-influenza drug oseltamivir. Generally speaking, there are three main methods to produce shikimic acid, which are included in the chemical synthesis and microbial fermentation as well as extraction from natural plants. The supplied review is focused on the extraction of shikimic acid from Chinese star anise as the main industrial source for shikimic acid production and presents some of the conducted studies for the extraction of shikimic acid from Chinese star anise and its purification and determination over the last decade.


In her novel Song of Solomon, Toni Morrison blends "the acceptance of the supernatural and a profound rootedness in the real world at the same time, with neither taking precedence over the other". ...


The zone-center phonons and dielectric properties of orthorhombic brookite and cotunnite structures TiO2 were studied in the framework of density functional perturbative theory. The dielectric properties of brookite and anatase structures are similar. The calculated static dielectric permittivity of brookite is found to be slightly higher than that of anatase, but far lower than that of the rutile structure. This is in contrast with the recent experimental report on brookite flowers. Our study suggests that the static dielectric constant of cotunnite structure is smaller than those of rutile and brookite structures. We obtained the full phonon band structure and elastic properties of these structures. The bulk modulus and Debye temperature of brookite are intermediate between those of the anatase and rutile structures. The obtained value of 301 GPa for the bulk modulus of cotunnite is in good agreement with the stiffness of the material reported experimentally. Because of the similarity in z-direction packing of the TiO6 tetrahedron between brookite and rutile structures, the elastic constants associated with the z-polarized movement of atoms in brookite are similar to those of the rutile structure. The elastic constants of brookite associated with the movement of the atoms in x-y plane, are similar to the corresponding constants in anatase and rutile structures. This demonstrates the similarity between the packing character of the brookite structure with both anatase and rutile structures. So, the lattice dynamics of brookite is intermediate between those of anatase and rutile polymorphs. The calculated phonon density of states of cotunnite shows that it is stable at ambient pressure.


Introduction One hundred years ago-and with the blessing of the Province of Quebec Association of Architects (PQAA)-a Department of Architecture in McGill University's Faculty of Applied Science (Engineering) was established to provide a professional studies program in architecture. After a brief apprenticeship, and passing the "Professional Practice" exam, graduates were accepted by the PQAA, the B.Sc. Arch. being considered the equivalent to passing the compulsory architectural examinations taken by tutorship candidates seeking admission to the profession. This paper outlines the teaching of one particular field, architectural history, during the first years of McGill's architecture program.


A three year experiment from 2014 to 2016 was conducted to assess the effect of a nitrification inhibitor (NI) DMPP, and nitrogen (N) application rates in a commercial peach orchard (889 trees ha-1) in a drip irrigated calcareous soil in the Ebro Valley (Lleida, Spain). The mineral content of leaves and fruits, vegetative growth and total yield were monitored each year. A significant effect of NI was observed. Increasing N application rates and the use of NI increased the tree canopy area and N content of the leaves and fruits. The use of NI could be an effective way to minimize the use of fertilizers in orchard systems, reducing the environmental impact. Yield was affected by the N dose and timing of application. The highest yield (58.6 t ha-1 with a fruit diameter higher than 65 mm) was recorded in 2015, applying only 50 kg N ha-1 plus NI, in fruit growth phase I. no negative visual effects were observed in the field except for trees with lower N doses (25 kg N ha-1). Darker leaves were visually observed in the NI treatments. More experiments need to be established to corroborate these findings.


In order to investigate the distribution of dominant Bifidobacterium species in intestinal microflora of Korean adults and seniors, SDS-PAGE profiles of whole cell proteins were used for the identification of bifidobacteria. To confirm the reliability of SDS-PAGE, the Bifidobacterium species identified by SDS-PAGE of whole cell proteins were validated by using 16S rDNA sequencing analysis. The results of SDSPAGE corresponded well with those determined by the analysis of 16S rDNA sequencing. Based on the analysis of SDS-PAGE patterns on unidentified fecal strains which showed positive in fructose-6-phosphate phosphoketolase activity, B. adolescentis, B. longum, and B. bifidum were identified in the feces of adults, and B. adolescentis, B. longum, B. bifidum, B. breve, and B. dentium were identified in those of seniors. In most of the fecal samples tested, the predominant Bifidobacterium species consisted of only a few species, and differences in the distribution and numbers of Bifidobacterium species were observed between adults and seniors. B. adolescentis and B. longum were found to be the most common species in feces of adults, but not in seniors. Accordingly, the distribution and abundance of bifidobacteria in the human intestinal microflora varied depending on the age of hosts.


Purpose. Despite improved treatments using proteosome inhibitor- and immunomodulator-based (thalidomide) therapies human multiple myeloma (MM) still remains an incurable disease. New therapeutic targets or unique drug-combinations are needed to further improve treatment outcomes. Our purpose was to investigate the use of small-molecule inhibitors of the nuclear export (SINE) in combination with proteosome inhibitors (PI), bortezomib (BTZ) and carfilzomib (CFZ) as a potential treatment for MM both in vitro and ex vivo. Methods. Previously, we reported that blocking nuclear export of topo IIα with SINE sensitized MM cells to topo II poisons. In this study, we used SINE inhibitors developed by Karyopharm Therapeutics, KPT-185, -249 and a new clinical compound KPT-330. In addition we investigated the use of KOS-2464 (BMS), an effective and relatively non-toxic analog of the known CRM1 inhibitor LMB. To test the efficacy of these inhibitors, we treated human MM cell lines, RPMI-8226, U266B1 and NCI-H929 with SINE +/- PI. MM cell lines or MM patient bone marrow aspirates were placed at high-density conditions and treated for 20 hours with KPT-drugs (300 nM) or KOS-2464 (10 nM), either concurrently or sequentially with 10-40 nM BTZ or CFZ. Cells were then assayed for cell viability by an automated CellTiter-Blue (Promega) analysis. Additional experiments were performed to investigate time-course of drug action and dose-dependence. In addition, treated cell lines or CD138+/light chain+ patient MM cells were assayed for induction of apoptosis by cleaved caspase 3 staining and flow cytometry. To determine if the SINE blocked CRM1-mediated export, treated cells were separated into nuclear and cytoplasmic fractions and assayed for export of p53 and topo IIα. Immunofluorescent microscopy was used to confirm fractionation results. In addition, CRM1 expression levels were measured in all treated cell lines by both Western blot and quantitative PCR. Results. SINE used in combination with PI were highly effective against both MM cell lines and patient MM cells. We found that SINE blocked nuclear export of both p53 and topo IIα as shown by nuclear/cytoplasmic fractionation and also by immunocytochemical staining. Using the CellTiter-Blue assay, we found that all SINE tested had low IC 50 values (nanomolar) as single agents and functioned synergistically with BTZ and CFZ (CI Citation Format: Joel G. Turner, Jana L. Dawson, Christopher L. Cubitt, Michael Kauffman, Sharon Shacham, Daniel M. Sullivan. Combination therapy of human multiple myeloma using proteosome and CRM1 inhibitors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2066. doi:10.1158/1538-7445.AM2013-2066


Input shaping convolutes the reference signal with a sequence of impulses, whose amplitudes and timings are designed to produce a shaped reference that avoids exciting lightly-damped modes to reduce residual vibration from a quick movement. The input shaper can be made robust to uncertain mode parameters by adding more impulses, which delays the reference signal, resulting in longer move time. Instead of using more impulses, in this paper, a feedforward-feedback control system, based on the quantitative feedback theory, is placed in the loop to match the closed-loop system, with uncertain plant, to a known reference model. The feedforward-feedback system handles the uncertainty, so the input shaper, placed outside the loop, needs not be robust. The closed-loop system emphasizes on selected frequencies and reduces the cost of feedback. It is shown that the proposed feedforward-feedback system is less conservative than the pure-feedback system. Other sources of vibration such as external disturbances and noise can be handled by the feedforward-feedback system as well. Simulation shows that the proposed technique can withstand large plant uncertainty with fast move time when compared to traditional robust input shaper.


A total of 1,936 pigs were transported through 8 trips (8.4 ± 0.5 h) from two grow-to-finish farms to a commercial slaughter plant, all located in Southern Brazil. On each trip, a sub-sample of each load (36 barrows/load, weighing 118.9±9.8 kg) was randomly allocated into one of the following loading densities during transport: 200 kg/m² (D200), 235 kg/m² (D235), and 270 kg/m² (D270). Behavioral recordings of postures and activities were made during transportation and lairage using video-cameras. At slaughter, blood samples were collected to assess the concentrations of creatine kinase (CK) and lactate. Carcass weights and skin lesion scores were assessed on-line, and meat quality was evaluated in the longissimus thoracis (LT) muscle by assessing pH, color and drip loss. During transportation, the proportion of animals lying down was higher (P < 0.05) in D200 and D235 groups compared to D270. The proportion of sitting animals during transportation was higher (P < 0.01) in D270 compared to D200. In lairage, D200 and D235 pigs stood more compared to D270 (P = 0.01), while the proportion of lying pigs was higher (P = 0.02) for D270 pigs compared to D200 and D235. The frequency of drinking bouts in lairage was higher (P < 0.05) for D200 group compared to D235 and D270. The levels of CK were lower (P < 0.05) in D200 pigs transported compared to D270. Lesion scores tended to be higher (P = 0.06) in D270 carcasses compared to D200 and D235. A tendency for lower (P = 0.10) pH1 values in the LT muscle of D270 pigs compared with D200 pigs was also found. Based on the results of this study, the application of lower loading densities (≤ 235 Kg/m²) in the truck allows pigs to have sufficient space to rest, travel more comfortably and arrive less fatigued at the slaughter plant.


Abstract In this paper experiment design for identification of ill-conditioned systems is studied. A short overview of recently proposed techniques is presented. These are mainly based on a singular value decomposition (SVD) of an estimated gain matrix. A summary of this approach with some extensions is given. Another approach is to find a D-optimal solution; the result is essentially the same as found by SVD methods. A result is that it is very important properly to excite the so-called low-gain direction of the system. The methods are motivated by the desire to guarantee integral controllability in model based control designs such as model predictive control (MPC). The dynamics of the process have not been a consideration in these works. However, it is well known from practical studies and simple models that high gains tend to be associated with slow dynamics and low gains with fast dynamics. For experiment design, it is useful to know how general this behaviour is. In this paper it is shown analytically that this indeed is a general property. Simple examples from the literature are used to support the result. Some possible modifications to existing design methods are given for situations, where the dynamics are not aligned with the gain directions.


s SiBr4 + n RMgX RnSiBr4–n + n MgXBr (A) The chemoselective and efficient deprotection of (primary, secondary and aromatic) silyl ethers using catalytic amounts of TMSBr in various solvents has been reported.8 The best results were obtained using methanol as the solvent. A bis-[tert-butyldimethylsilyl (TBS)] ether 1 was effectively cleaved to afford the corresponding diol 2 in 92% yield. (B) An efficient Prins cyclization reaction to construct tetrasubstituted 2,6-cis-4,5-dibromo tetrahydropyran (THP) rings with high stereoselectivity in good yields has been developed.9 The cyclization of γbrominated homoallylic alcohol (Z)-3 and cyclohexane carboxaldehyde (4) proceeded smoothly with 1.2 equivalents of TMSBr to afford 5 in 95% yield as a single isomer. THP product 5 was selected to perform a series functionalizations, such as debromination and further epoxidation or hydroxylation.10–12 OMe O TBSO OTBS OMe O HO OH TMSBr (0.1 equiv) MeOH 92% yield 1 2 r.t., 10 min


The article studies nature and methods of integral assessment, content and functions of assets to ensure socio-economic development are considered. Expediency of using method of integral evaluation and comparison to form assets in the areas of Cherkasy region on the basis of the current system of statistical indicators is determined. On the basis of integral index evaluation method primary integral and general integral indices are calculated, and comparison method is used for ranking studied subjects according to their achieved results and their comparison with the same regional average value. It was found that the advantage of method of integral analysis in areas is that it allows you not only to rank studied subjects through comparison of some calculated values but also makes it possible to quantify the effectiveness of business entities.


The "Compound Unit" of the international-standard experimental textbook produced by Jiangsu Education Press is an important design in the transformation from lecture-centered style to language practice style.The four main items are: Theme Compound Unit,Master-piece Proposal in Reading,Special Topic and Appendix.There is special value and mental route in its design and value.


Skin rashes following allogeneic hone marrow transplantation are common. The majority are either drug reactions or manifestations of acute or chronic graft‐versus‐host disease (GVHD). We describe a previously unreported manifestion of a donor allergic response pattern in the recipient of an allogeneic hone marrow transplant who presented with papular urticaria in the post‐transplant period.


Detection and quantification of immune cell subsets and changes in the tumor immune microenvironment would be a powerful tool to correlated to response in cancer immunotherapy. Currently, biopsies used to monitor the tumor microenvironment suffer from sampling error, restricted sampling over time and to inaccessible tissues/organs, and do not reflect discordance across tumor lesions of the same patient. Immuno-PET detection of CD8-expressing T cells is a promising translational imaging approach to assess CD8+ tumor-infiltrating lymphocytes (TILs) pre- and post-therapy. We have developed a fully human anti-CD8 antibody that was radiolabeled with the positron emitting radionuclide Zirconium-89 (89Zr) using the bifunctional chelator p-SCN-Bn-Desferoxamine (DFO). CD8-genetically humanized immunocompetent mice were used to validate dose dependent targeting of 89Zr-CD8 to lymphoid tissues. Next, two models were developed to monitor the response of the T cell activating bispecific antibody REGN1979 (CD3xCD20). In the first model designed to lack a CD8 antigen sink, Raji lymphoma cells were co-implanted with human peripheral blood mononuclear cells (hPBMCs) in immune deficient NSG mice and treated with REGN1979. Here, 89Zr-CD8 detected a two-fold increase in CD8+ TILs as quantified by flow cytometry compared to control antibody treated mice. To determine if 89Zr-CD8 could detect changes in CD8+ TILs in the presence of increased circulating and splenic T cells, a different model was developed. Raji lymphoma cells were implanted subcutaneously and hPBMCs were implanted intraperitoneally in immune deficient SRG-15 mice (hSIRP KI, Rag2 KO, IL2Rg KO, hIL-15 KI). Due to the humanization of IL-15, T cells from the implanted hPBMCs rapidly expanded and produced a CD8 antigen sink. In the SRG-15 model, total tumor uptake of 89Zr-CD8 was lower and spleen uptake higher than in the NSG model due to the presence of the antigen sink. These SGR-15 mice treated with REGN1979 also demonstrated an increase in CD8+ TILs by flow cytometry that was specifically detected with 89Zr-CD8. This work demonstrates that 89Zr-CD8 can specifically detect CD8+ T cells in lymphoid tissues of CD8 humanized mice and therapy-induced alterations of CD8+ TILs. Importantly, the detection of CD8+ TILs occurs in both the presence and absence of an antigen sink. This work supports the clinical translation of 89Zr-CD8 immuno-PET to investigate its utility for predicting and monitoring response in patients undergoing immunotherapy. Citation Format: Richard Tavare, Makenzie Danton, Jason T. Giurleo, Marcus P. Kelly, Sosina Makonnen, Carlos Hickey, Tomas C. Arnold, Dangshe Ma, William C. Olson, Gavin Thurston, Jessica R. Kirshner. CD8 immuno-PET using a fully human mAb can detect increases in tumor-infiltrating T cells by a T cell activating immunotherapy [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1131.


The invention pertains to a key device for water-saving irrigation, which is a wall-attached fluidic nozzle that realizes variable spraying; the nozzle comprises a static plate, a moving plate, a spraying body, a spraying tube, a rotating seal mechanism, a knighthead, a spacing ring, a reversing mechanism and a fluidic element body and is characterized in that the static plate and the moving plate are added to a nozzle spin; the moving plate is pressed to match a hollow shaft, and rotates along with the nozzle. The fluidic element body comprises a reverse air supply nozzle, a signal water receiving nozzle, an outlet cover plate, a signal water intake nozzle and a honeycomb duct; signal water in a signal water receiving nozzle leads one side of main jet-flow to form a low-pressure spiral area at intervals; by opening and closing an air supply receiving nozzle, the other side of the main jet-flow is led to switch between high pressure and low pressure so as to form a differential pressure between the right and the left ends of the main jet-flow, thus realizing the wall attachment of water flow and finishing direct spraying, stepping and reverse running of the nozzle. The static plate and the moving plate at the position of the nozzle spin move relatively to change the area of stopflow at an inlet and regulate the flow and the pressure of the inlet so as to change the spraying range of nozzle and realize variable spraying.


A case of Failed total knee arthroplasty with difficulty in reoperative planning is reported. A 65-year-old women with rheumatoid arthritis, complained of severe pain in her left knee. Radiographs revealed displacement and loosening of both femoral and tibial components with the femoral lateral condyle and tibial medial condyle refleching the amount of bone that had been lost. We reimplanted a Press Fit Condyler modular type with metal spacers using the thickest stabilized HDP spacer. Excellent results were obtained. Histological evaluation of synovial tissue revealed many lymphocytes and foreign-body giant cells containing polyethylene parhcles. It was suggested that polyethylene debris may have induced the osteolysis.


In detail the process of construction of the new raisebore is described,and the introduction of construction technology in different processes,such as directional drilling,the new raisebore,the new shaft boring machine,sliding.Finally,present the application examples of these new technologies in the shaft construction of hydropower and coal mine.The new technology can provides a reference to determine construction scheme of large diameter deep shaft.


2-chloroethanol (CE, ethylene chlorohydrin, chloroethyl alcohol, ethylene glycol chlorohydrin) is a highly toxic chemical compound of general toxic effect; colorless viscous liquid with a weak ether odor; Is readily soluble in water, ethanol, acetone, 1,2-dichloroethane, chloroform. It is used as a solvent for inorganic salts, in organic synthesis (dissolves acetyl cellulose). Used to produce ethylene oxide, thiodiglycol, some dyes, pesticides and pharmaceuticals.1‒3 In emergency situations, violation of safety precautions CE can induce inhalation, oral poisoning, easily penetrates through skin. After intoxication of CE are amazed the central nervous system, cardiovascular system, kidneys, liver and other organs.1‒4 There are reasons to believe that CE metabolites can cause mutagenic, carcinogenic, and teratogenic and immunotoxic effects.3 Dysfunctions of immune system, synthesis of lymphocytes and other blood cells of cytokines with chronic intoxication of CE with purpose of targeted correction of immune homeostasis for prevention of infectious complications and disease have not been studied.1‒6 The aim of the study was to assess the chronic effect of CE (60days, daily subcutaneously 0.05 LD50) on immune responses, the function of Th1 and Th2 lymphocytes, as well as on the content of IFN-γ, interleukins IL-2, IL-4, pro-inflammatory (TNF-α, IL-6) and anti-inflammatory cytokines (IL-10, IL-13)


The main purpose of "Gutian Conference"solved the problems of C.P.C's development in the Fourth Workerpeasant Red Army,especially in the party's organizational development.With regard to the problems such as party's democratic centralism,the devolopment of the party's cadres and party members,"Gutian Conference" put forward a number of targeted solutions.The program also drew a considerable significance on C.P.C's development in the Soviet Area.


There is a general agreement that landmarks in route directions should be perceptually salient and stable objects. Yet, other attributes, such as (animated) motion, can also attract visual attention and make entities salient. In the present study, we investigate if and when speakers refer to moving entities in route directions and how listeners evaluate such instructions. We asked speakers to watch short videos of different crossroads with and without moving landmarks and give directions to listeners, who in turn had to choose a street on which to continue (Experiment 1) or choose the instruction they most preferred among three route directions (Experiment 2). Results reveal that speakers mentioned moving entities, especially when the trajectory was informative for the place where a turn should be taken (Experiment 1). Listeners had no problem understanding instructions with moving landmarks (Experiment 1). Yet, participants chose instructions with stable landmarks more often (Experiment 2). These results are discussed in relation to automatic route directions generation.


Following the 6th revision, the 10th revision of ICD is another revision of significance as a milestone. The major change is the replacement of pure numerical form of code structure by alphabet - numerical one. There is also progress in the classification thinking in ICD-10, marking the progress toward maturity of the thinking in disease classification. Descriptions are given to the general condition, revision of its contents, the conception of classified 'family' of disease classification, and the new renewal mechanism in the 10th revision.


An aromatic analogue of the side chain hydroxyl/main chain amide of Ser or Thr was used for the construction of artificial receptors for N-acetylneuraminic acid (Neu5Ac), the most common occurring sialic acid. The acyclic receptors, incorporating only neutral recognition sites, are able to bind Neu5Ac with an overall binding constant β2 of 105M–2 in a competitive solvent, such as water-containing [D6]DMSO. Both receptors show remarkable selectivity for Neu5Ac over D-glucuronic acid (GlcA).(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)


Thank you for downloading southern women at the seven sister colleges feminist values and social activism 1875 1915. As you may know, people have look hundreds times for their chosen readings like this southern women at the seven sister colleges feminist values and social activism 1875 1915, but end up in infectious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some infectious virus inside their laptop.


It is determined that the improvement of public administration relations is associated with the solution of a number of problems that arise as a result of non-compliance of the current state of these relations with the requirements of today. A healthy lifestyle and physical culture and sports are designed to become a social phenomenon and a state ideology that promotes a strong state and a healthy society. The development of physical education is due to civilizational factors, in the solution of which it can act as a means of cultivating in the public consciousness the values of creativity, tolerance, solidarity, personal development, and optimization of communication and conflict resolution. The process of state regulation of physical culture and educational activities in higher education institutions as a special type of activity, the results of which are useful for society and student youth, is analyzed. The process of development of physical culture and educational activities is outlined and it is specified that the field of providing physical culture and health services should be a strategic goal of reforming the work of public authorities in this direction. The current formation of economic relations in the country requires a new look at physical education and education as a specific type of social activity aimed at young people, their physical condition and health. The current state and issues of state regulation of physical culture and educational activities in the context of the actualization of public relations in Ukraine are revealed. The need to unify the mechanisms of state regulation of physical culture and educational activities in higher education institutions of Ukraine during the transformation of civil society is theoretically substantiated, which differs in the application of an integrative approach to the formation of tools of purposeful influence of the state on the development of education on new values. A set of mechanisms of state regulation of physical culture and educational activities in higher education institutions in Ukraine, including regulatory, economic, financial, organizational, socio-political, motivational, informational, educational, cultural and communicative mechanisms and outlines their content.
Keywords: state regulation, development, mechanisms, physical culture and educational activity, higher education.

References


Service industries are the largest sector of developed economies. Professional staff competes in markets to sell their firms' customized services, but little research has been reported on successful personal selling. This paper reviews literature on service-mindedness, services, market structures and features. It illustrates theoretical concepts by describing the background, characteristics, motivations and positioning of sellers and buyers in a customized inter-cultural services market in Thailand, where bar 'girls', who may engage in 'open-ended' heterosexual prostitution, personally sell their services to men – 'farang'. The paper identifies six dimensions related to the 'substance' of a customized service, and, drawing on published interview data, illustrates how customization shapes positioning, power deployment and management of service delivery. It identifies human resource development needs of market participants. It argues that research into customization and related issues in competitive, global inter-cultural service markets may assist human resource developers to develop personal selling skills for professional and business success.


The invention relates to an electric energy quality harmonic disturbance source platform. In the disturbance source platform, an input circuit breaker cabinet, a disturbance source input switch cabinet, an output filter and switch cabinet and an output test cabinet are all connected to a 10kV bus; the disturbance source input switch cabinet, an input transformer and unit cabinet, the output filter and switch cabinet, a switch and output transformer cabinet and the output test cabinet are sequentially connected; the output test cabinet, the input transformer and unit cabinet are connected with the input control cabinet; the electric energy quality harmonic disturbance source outputs 0-50 times or stacking folds of standard harmonic voltage current source with adjustable amplitude and phase under the conditions of 10kV and 0.38kV fundamental voltages, and the maximal total harmonic distortion THDu is less than 20%. The platform can be used as a standard electric energy quality harmonic output source and a power grid equipment assessment platform for testing operation stability of a power grid and performance of power grid equipment under the harmonic output condition; electric energy quality problems about sag, fluctuation and three-phase imbalance of the power grid are simulated, and a platform is built for test, analysis and assessment of electric energy quality improvement.


The designers claim that Wisconsin Power & Light Co`s new energy management system is the first system of its type in the world in terms of the comprehensiveness and scope of its stored and retrievable data. Furthermore, the system`s link to the utility`s generating assets enables powerplant management to dispatch generation resources based on up-to-date unit characteristics. That means that the new system gives WP&L a competitive tool to optimize operations as well as fine-tune its EMS based on timely load and unit response information. Additionally, the EMS gives WP&L insight into the complex issues related to the unbundling of generation resources.


We consider the problem of discovering overlapping communities in networks which we model as generalizations of Graph Packing problems with overlap.
We seek a collection $\mathcal{S}' \subseteq \mathcal{S}$ consisting of at least $k$ sets subject to certain disjointness restrictions. In the $r$-Set Packing with $t$-Membership, each element of $\mathcal{U}$ belongs to at most $t$ sets of $\mathcal{S'}$ while in $t$-Overlap each pair of sets in $\mathcal{S'}$ overlaps in at most $t$ elements. Each set of $\mathcal{S}$ has at most $r$ elements.
Similarly, both of our graph packing problems seek a collection $\mathcal{K}$ of at least $k$ subgraphs in a graph $G$ each isomorphic to a graph $H \in \mathcal{H}$. In $\mathcal{H}$-Packing with $t$-Membership, each vertex of $G$ belongs to at most $t$ subgraphs of $\mathcal{K}$ while in $t$-Overlap each pair of subgraphs in $\mathcal{K}$ overlaps in at most $t$ vertices. Each member of $\mathcal{H}$ has at most $r$ vertices and $m$ edges.
We show NP-Completeness results for all of our packing problems and we give a dichotomy result for the $\mathcal{H}$-Packing with $t$-Membership problem analogous to the Kirkpatrick and Hell \cite{Kirk78}. We reduce the $r$-Set Packing with $t$-Membership to a problem kernel with $O((r+1)^r k^{r})$ elements while we achieve a kernel with $O(r^r k^{r-t-1})$ elements for the $r$-Set Packing with $t$-Overlap. In addition, we reduce the $\mathcal{H}$-Packing with $t$-Membership and its edge version to problem kernels with $O((r+1)^r k^{r})$ and $O((m+1)^{m} k^{{m}})$ vertices, respectively. On the other hand, we achieve kernels with $O(r^r k^{r-t-1})$ and $O(m^{m} k^{m-t-1})$ vertices for the $\mathcal{H}$-Packing with $t$-Overlap and its edge version, respectively. In all cases, $k$ is the input parameter while $t$, $r$, and $m$ are constants.


The topic of my Bachelor thesis is the ?Institute of exile and its consequences in practice?. Main aim of this thesis is to describe this issue from the perspective of the general definitons, legislation and the progressive integration into the Czech law, where it is a part of three interlinked pillars. Another aim is to explain the function of the individual authorities that are responsible for this issue and should help the endangered people. Among the authorities, which are committed to solve these incidents, belong the Police Czech Republic, courts, intervention centres. These authorities must collaborate. It also deals with the analysis of the file materials which present the factors mentioned above in practical terms. It focuses on one of the possible solutions ? the judicial way.


First, I want to thank Ralph for that wonderful presentation. After listening to all that, I can hardly wait to hear what I am going to say. Preparing these Kober Medal presentations requires a tremendous amount of work. When I first asked Ralph if he would do me the honor of making these remarks, he asked if I had any guidelines I wanted to give him. I responded: Ralph you know that I would want something simple and modest — not overly ostentatious or hagiographic — no matter how long it takes.


Pharmacokinetic parameters of amitriptyline were studied on eight healthy youngadult volunteers. The concentration-time curve of amitriptyline fitted in with a two-compartment ki-netic model. Its parameters were as follows: V/F(c)=1231±484 L; t1/2β=41.3±22.3h; t1/2Ka=0.873±0.687h; CL_(s)=71. 5±41.2 L/h. The concentration-time curves of the two metabolites, nor-triptyline and 10-hydroxynortriptyline fitted in with one-compartment models. The parameters of nor-triptyline were as follows: t1/2Ke=58.5±34.3h; t1/2Ka=3.20±2.56h; CL_(s)=115.4±46.9 L/h.The parameters of 10-hydroxynortriptyline were as follows: t1/2Ke=42.1±23.6h; t1/2Ka=3.57±2.96h; CL_(s) 423.7±631.5 L/h. it was discovered that the T_(peak) of the two metabolites were significant-ly longer than that of amitriptyline. Their t1/2Ka were correspondingly longer and the c_(max) were lower.The MRT of metabolites were longer than that of the parent drug. The clinical significance of thepharmacokinetics of the metabolites was discussed.


Information and data concerning the thermal expansion characteristics of the solid and liquid phases of unalloyed plutonium have been collected from published and unpublished sources and evaluated, and are presented to provide increased availability in compact form.


An AD-cDNA library was constructed by using materials from legume Lotus japonicus.The library transformation efficiency is 2×106 transformants per 3 μg DNA,the empty transformants without cDNA insert is 12.5% of total transformants.The library was screened with the protein kinase domain of NFR1(NFR1-PK) as bait by yeast two hybrid approach and 120 positive clones were selected on SD/-Leu-Trp-His-Ade plates containing X-gal.80 clones were further confirmed by rescuing the plasmid from yeast,amplifying the DNA insert by PCR and retesting the phenotype.The positive clones were sequenced and searched for NCBI database by blast analysis.4 genes interacted with NFR1-PK including JAB1 and ARID domain(AT-rich interacting domain).To determine the expression of these genes in Lotus japonicus,the RT-PCR products of these genes were analyzed in different tissues.The result provided basis to study NFR1 function in Nod factor signal transduction.


1. Of the 3,559 individuals who were tested with diagnostic doses of tuberculin and examined by x-ray, 48.0 per cent were found to be infected with tuberculosis. 2. If the tuberculin test alone were employed, the incidence would be 32.0 per cent infection. If the x-ray were the only medium of finding infection, the incidence would be 33.0 per cent. The incidence, according to x-ray and tuberculin, in different age groups was noted. 3. Sixteen (16.0) per cent were anergic to diagnostic doses of tuberculin, while 15.0 per cent were positive to tuberculin and had either masked or non-pulmonary lesions. 4. In this locality, if 48.0 per cent of the population (100,000) are infected with the germs of tuberculosis, with a mortality rate of 0.07 per cent and a morbidity rate of 0.01 per cent, the suggestion is made that they possess a relative immunity to the "White Plague".


Several CuII complexes of carbamoyldicyanomethanide (cdm, C(CN)2(CONH2)−) with various bidentate co-ligands have been prepared and characterised to examine the persistence of a previously observed dual-synthon 'heterotape' hydrogen-bonding motif that incorporates both amide and nitrile functionalities. Using 2,2′-bipyridine or 1,10-phenanthroline as co-ligands yields dimeric complexes of the form [Cu(cdm)Cl(L)]2·2MeOH (L = 2,2′-bipy 1 or 1,10-phen 2). However, the bridging species in these two dimers are different; μ2 chloride bridging in the bipyridine dimer and η1(N):η1(N′) cdm bridging in the phenanthroline complex. The subtle change in co-ligand prompts a change in the bridging mode that prevents the desired motif from forming in the phenanthroline structure, an effect that appears to arise from the greater π-stacking of the phenanthroline groups. The dimeric complex [Cu(cdm)(acac)(H2O)]23 and the monomeric complexes [Cu(cdm)2(NH2(CH2)3NH2)] 4 and [Mn(cdm)Cl(1,10-phen)2] 5 also fail to display the expected tape motif, although other complicated hydrogen bonding is present, and their structures are discussed.


A method of hardening a dental glass ionomer cement by irradiation with light to accelerate the initial hardening, the cement comprising a fluoroaluminosilicate glass powder, a polycarboxylic acid and water is disclosed. In addition, the light used in the method for hardening the dental glass ionomer cement is preferably a light having a wavelength in the range of 320 to 3000 nm, and the irradiation intensity and the irradiation time with the light are preferably 200 to 3000 mW / cm · 2 · and 1 to, respectively 180 seconds. According to the method of hardening the dental glass ionomer cement of the present invention, the time for sensitization to water and the initial hardening time can be shortened without requiring special measures to prevent sensitization to water with a varnish or the like.


Abstract In 2019, Thailand ratified the International Labour Organization Work in Fishing Convention to protect migrant fishers. The Thai government vigorously promoted the Convention among its constituents. Yet, despite the government's proactivity, such norms have been weakened upon local translation. This phenomenon is not readily explained by existing norms research that pays scant attention to norms in the domestic space. To address this oversight, this article unpacks domestic processes of norm validation and makes a two-step argument. First, it argues that norm validation is crucial for instigating domestic implementation by allowing stakeholders to deliberate and contest the 'appropriate' application of norms. Second, it argues that the locally acquired normative understanding, as influenced by norm antipreneurs, or actors who defend the status quo, weakens norm implementation while the norms' discursive strength is retained. In presenting the findings, this article contributes to the norms literature by illuminating a new life given to validated norms. The contribution also interrogates norms' global–local dynamics by scrutinizing norm contestation and the extent to which it generates an internalized sense of legal obligation to implement international norms.


A trapped vortex cell, (TVC), is a flow control device consisting in a cavity embedded on the upper surface of an airfoil, designed to trap a steady vortex. By the interaction with the vortical cell's ow, the incoming boundary layer becomes more energetic, and it is thus less prone to separation. Wind tunnel tests by De Gregorio et al. [2] and by Lasagna et al. [1] have shown that to make this control effective the cavity flow itself must be the target of a control action. In particular, the latter authors have shown that the airfoil drag can be substantially reduced with respect to the clean airfoil by applying suction into the cavity region and that this technique is superior to a classical boundary layer suction system, for the same suction flow rate. One goal of this work is to further investigate on the drag reduction mechanism of the TVC with suction technique. Furthermore, a second control technique, based on a synthetic jet device (SJ) which injects momentum into the cavity in order to energize the vortical cell's flow, is considered. Interest in this technique is raised since it is far more effcient than steady suction


As the adoption of cloud computing continues to progress and becomes a critical element in the production and post-production processes of the movie industry, new strategies for protecting content will have to emerge. The lack of sufficient content protection may hinder the adoption of cloud in the industry, which could deprive the community of the many operational and financial benefits that this new approach to delivering technology services can offer. This paper defines four types of trust assumptions and their relative strength in the different cloud deployment models. It addresses the major threats associated with cloud -such as data breaches, account hijacking, denial of services, or malicious insiders -with a particular focus on content protection. The cloud increases exposure to risk. The paper explores two use cases: digital delivery and processing. They demonstrate that the clever use of hybrid cloud and new advanced technologies, associated to proper security, may allow secure deployment in the cloud without sacrificing content protection.