In this work, we study the generation and evolution of phase-shifts between the modal interference pattern and the thermally-induced index grating due to pump-power changes. This study is not only important to understand new mitigation strategies based on controlling such phase-shifts, but also to comprehend how pump/signal noise can trigger TMI. Understanding how such a phase-shift can develop from a pump/signal change is not trivial, since the movement of both the MIP and the RIG are thermally driven and, therefore, should have similar time constants. Our simulations show unequivocally that a change of the pump power will lead to the generation of a phase-shift and the physical reason for this behavior is unveiled. The main reason is an increased sensitivity of the MIP to temperature variations because the local beat-length changes of the MIP are accumulated along the whole fiber length. Therefore, the further downstream the fiber a MIP maximum is (i.e. closer to the pump end in a counter-pumped configuration), the stronger and faster its position shift will be. This insight shows a way to obtain more TMI-resilient fiber designs and may help understanding the core area dependence of TMI.


In this work it is presented a computational model of a magnetic levitation system based on stacks of high-temperature second generation superconducting tapes (HTS) GdBa2Cu3O7-x. Calculated magnetic field and the current distributions in the system for different stacks geometries in the zero-field cooling mode are also presented. The magnetization curves of the stacks in the external field of a permanent NdFeB magnet and the levitation force dependence on the gap between the magnet and the HTS tapes stack were obtained. A model of the magnetic system, oriented to levitation application, is given. Results of modeling were compared with the experimental data.


Catalonia is a nation with it's own language, its own culture, own policy and own history it is said. A non-independent nation that is living it's ordinary life flagging its banal symbols as if it al ready was an independent state. Some catalanistas assert that this kind of weirdness could be the death row for Catalonia and its future as in independent nation of its own. They state that it is only through an implementation of "hot" nationalism, not banal, that independence is accomplished. La Diada 2012 – the national day of Catalonia was a day when around 1.000.000 protesters walked the streets of Barcelona waiving the Catalan flag, shouting phrases with one clear message, independence. A complexity between banal and hot nationalism was demonstrated this day. However, through the banal symbols present at La Diada 2012, Catalonia showed it is not Spain, and through this a hot movement arose to fight to find an escape from Spain. Previous years La Diada may have been hot but 2012 was the year when banal catalanism once again became "hot" Catalan Nationalism.


The Baixian Mn deposit is a large scale Mn deposit in Triassic Falang Formation of South China.The material source of Mn deposit is Mn-bearing carbonate rock and sedimentary Mn ore bed.The karst structure provides the metallogenetic channel and space.The Mn oxide and Mn hydroxide commercial deposit of leaching enrichment and karst accumulation type has been found,which has developed the new ore-prospecting idea of posterior metallogenesis in this area.


This study integrates trust in government, fear of COVID-19, and economic dependence on tourism into the protection motivation theory (PMT) framework to predict resident hospitality during the COVID-19 crisis. Structural equation modeling is utilized to analyze 281 questionnaires from destination residents. Findings show that threat severity and threat vulnerability can indirectly reduce resident hospitality through fear of COVID-19, whereas response efficacy and self-efficacy can directly promote resident hospitality. Trust in government can change the levels of threat severity, threat vulnerability, response efficacy, and self-efficacy, which in turn influences fear of COVID-19 and resident hospitality in different ways. Additionally, economic dependence on tourism is found as the most influential predictor of resident hospitality. Theoretically, this study contributes to the literature by developing a comprehensive and novel extended PMT model to understand the formation mechanism of residents' attitudes during the COVID-19 crisis. Practical implications can help better improve resident hospitality.


Store for stocking tubes therein, comprising means (4) for feeding tubes (1) into the store, and means (7) for unloading the tubes (1) therefrom, the store being located between said supply means (4)and said unloading means (7), characterized in that it comprises a plurality of supports (8) each of which defines a plane inclined towards said unloading means (7) and able to receive a plurality oftubes (1) from said supply means (4): each of said supports (8) being movable between a stand-by position where it is empty, a position of transit of tubes (1) in which it defines an inclined plane ,which connects said tube-supplying means (4) to said tube-unloading means (7), and a stock position in which it is full up.


A capacitive tactile probing system and the corresponding capacitance detecting system are developed to meet different measuring requirements.The principle of the probe and the capacitance sensor are illustrated.According to the measuring principle,the capacitance detecting circuit is the crucial component of the capacitive detecting system.Capacitance/digital converter(CDC)AD7747 chip is used in this circuit.The I2C communication procedure between MCU and AD7747 and the serial communication between MCU and host computer are compiled to realize the detecting and handle the data.The performance of Z-axis is test simply.Through analysis of the experiment data,the resolution of the capacitive sensing probe system achieves 0.02 μm and has a good repeatability.The possibility of the system is proved.


This paper summarizes the ways and measures in deepening teaching reform and the idea change in teaching in the operation of Wuhan Institute of Shipbuilding Technology. It also elaborates the gradually formed managerial characteristics, teaching characteristics and faculty characteristics in the institute.


Radiolaria, and siliceous microfossils generally (see the reports on silicoflagellates, ebridians, diatoms and phytolitharia) were encountered rather rarely in the cores recovered during Leg 13 of the Deep Sea Drilling Project. The presence of radiolarians in a more or less significant quantity was recorded in only a few cores from a few of the fifteen drilling sites. Samples reported on here are from the following five sites: Site 120 Gorringe Bank, north slope; 36° 41.39'N, 11° 25.94'W; water depth 1711 meters. Site 121 Alboran Sea, 36° 09.65'N. 04° 22.43'W; water depth 1163 meters. Site 127 — Hellenic Trench, northeastern margin; 35° 43.90'N, 22° 29.81 'E; water depth 4654 meters. Site 128 — Hellenic Trench, southwestern margin; 35° 42.58'N, 22° 28.10'E; water depth 4640 meters. Site 129 — Strabo Trench, northern margin; 34° 20.96'N, 27° 04.92'E; water depth 3048 meters. At Site 120, located in the Atlantic Ocean, Radiolaria recovered are of Albian and lower Aptian age. At the other four sites, all located in the Mediterranean Sea, Radiolaria are of Quaternary age. A few fragmentary Miocene specimens encountered at Site 124 (associated with other siliceous microfossils) are not taken into account in this report.


We will now see an analysis of policies and anti-communist political representatives who were in state power directly or as collaborators between 1948 and 1949, following the development of the two governments participating in that context speeches. This through official pronouncements in various writings published individually and in print, in addition to official government sources, mainly laws and decrees, reports of ministries and the legislature, presidential speeches, etc. This focus on the logic of the anti-communist argument based on the defense of Western democracy, capitalism, Western customs, and human rights from the state and their governments. In that direction to comparatively examine the anti-communist ideological justifications to analyze their positions, their public policies, repressive actions and decisions according to the different problems presented to them about the communist threat.


As per the feature of CPR1000 nuclear power plant,the design input and margin selection of main feedwater pump on conventional island are analyzed.It is indicated that the interface parameters between nuclear island and conventional island under best estimate condition should be used as input data for the selection calculation of main feedwater pump,while the pump should consider a margin of 5% of calculated result for flow rate and a margin of 10% of calculated outcome for resistance,which can meet the operation requirement of maximum continuous output of power plant and has good economic efficiency.


Diff Serv network architecture is the first choice for QoS of network. As a network buffer resource management, active queue management is the key technology to differentiated services. On the basis of the RIO-C (RED with IN/OUT and couple queue), this paper proposes a queue management algorithm INRIO-C (Improved nonlinear RIO-C). This algorithm takes nonlinear characteristics between the average length of the queue and packets loss probability into consideration, and proposes piecewise smooth discarding functions. By NS-2 simulation, INRIO-C algorithm is proved that it can improve system stability, increase the priority queue throughput, reduce packets loss rate of the system, and increase system capacity for burst traffic.


(Comparison of spontaneous precipitation and impaction methods for microbiological analyzes of indoor air) Microbial pollution is a key element of indoor air pollution; is caused by hundreds of species of bacteria and fungi. Two of the most widely used methods of air sampling are compared here: spontaneous sedimentation and solid-media impactation with one-stage Andersen sampler. Three collections were carried out in three environments with different characteristics in a University of Porto Alegre, Brazil: An auditorium with a capacity of 1164 people; and, in a small animal surgery center, at the recovery and induction anesthetic room, and at room surgery. In the auditorium the correlation coefficient was high (r = 0.775) and the coefficient of variation was lower in the passive samplings (CV = 25.93). In the surgical center samplings, the correlation coefficients were negative and the coefficients of variation were lower in the active methods. In all environments, opportunists fungi were identified such as Penicillium spp, Aspergilus spp, Cladosporium spp, among others.


Bacterial strains CS5 and CS121 were demonstrated to inhibit g rowth of Stagonospora curtisii significantly by testing in plate and liquid culture. Mechanism study showed that CS121 could produce siderophores in iron limited conditions, and supernatant of its liquid culture could suppress the dev elopment of leaf spot disease in detached Narcissus tazetta leaves. Recover y of strains marked genetically with kanamycin and rifamycin resistances indicat ed that CS5, CS51 and CS121 could colonize the root system of Narcissus tazett a.


This study is concerned with the origin, development, structure and arrangement of the fibers which are incorporated into the calcified matrix of dentin in mammalian teeth, with especial reference to the pig and human. Previous observations made on this subject are controversial and inadequate in many respects. Mummery (18%) describes collagenous fibers arising in the pulp which, he maintains, are incorporated into the calcified dentin. Von Korff ('05, '07)' in studies relating to the formation of dentin, concludes that the ground substance of dentin and bone are laid down similarly. StudniEka ( '06, '07), asserts that precollagenous fibers which arise in the pulp later become embedded in the dentin. Von Ebner ( '06, '09, '22), maintains that collagenous fibers are present in both the pulp and the dentin of the developing tooth. He denies, however, the relation between the fibers observed in the pulp with those observed in the calcified dentin. In later studies concerning the origin of dentin, Von Korff ('28, '30), describes radially arranged fibers in the pulp of the developing tooth which have since been known as Rorff's fibers. He also emphasizes the presence of a fibrous membrane on the periphery of the embryonic pulp and points out that the fibers which make up this membrane are the first morphological structures which can be identified in connection with the histogenesis of dentin.


The free-radical copolymerization of 1-vinylimidazole and sodium salt of acrylic acid yielded new polyampholytes; the reactivity ratios of comonomers were estimated to be 0.54 ± 0.06 and 1.3 ± 0.3, respectively. The position of the isoelectric point of polyampholytes gradually increased in the pH range from 3 to 7 with an increasing content of 1-vinylimidazole in the copolymer. It was shown that the as-synthesized copolymers can interact with bovine serum albumin and lysozyme to afford both soluble and insoluble complexes. The use of the crosslinked copolymer makes it possible to efficiently separate the model protein mixture.


A test program has been conducted at the Idaho National Engineering Laboratory to demonstrate that the concentration of volatile organic compounds within the innermost layer of confinement in a vented waste drum can be estimated using a model incorporating diffusion and permeation transport principles and limited waste drum sampling data. This final report summarizes the experimental measurements and model predictions for transuranic waste drums containing solidified sludges and solid waste.


Founded in 1999 by three Erasmus University students, the Dutch e-commerce firm Coolblue has gone on to experience exponential growth, mainly due to its obsessive focus on data and its two KPIs, the Net Promoter Score and EBITDA. In 2017, Coolblue's main aims – make customers happy and make money – were achieved and by 2018, its turnover reached €1.35 billion.

When the company started, the modus operandi at Coolblue was quite simple: get products from their providers and make sure they arrive to customers on time at the right location. However, with exponential growth and Coolblue's core values revolving around an always improving customer journey satisfaction, most decision-making became based on short-term planning. While the company's reliance on big data allowed customers to increase their trust in the company, the operation became more fractured and complex. Coolblue's lack of HR strategy also created a number of challenges, such as frequent team restructuring. Most of the decisions the company made were also centralized. Furthermore, with prices in electronics declining drastically year after year, Coolblue needed to find a strategy to expand not only beyond the Benelux borders but maybe even beyond its core business model.


The CN2R was created with the aim of deepening the knowledge on the psychotrauma and the resiliency processes according to an approach of course in its globality; it has for that four strong axes that are the research, the training and the identification of good practice, the diffusion of the knowledge and the animation of the places of care that are the regional centers of the psychotraumatisms created simultaneously to the CN2R. From its creation, the functioning of this center has been created a transversal axis to the presented axes, the partnership with the people leave... with and a coordinator


This paper introduces a maintenance support tool for C++ programs. The tool was extended by adding a documentation supporting tool(DT) and an OOD/OOP style guidelines supporting tool(OOD\ulcornerP-GT) to previous work results, the complexity measurement tool(CT) and the visualization tool(VT). The tool was named C++ MT. For the extention, we studied a documentation method of object oriented programs, analyzed and grouped the OOD/OOP style guidelines suggested in some works. The DT developed in this paper helps programmer understand, cange, and est programs, and also extract the reuse components. OOD/P-GT provides guielines for programmer to improve program quality.


In ultra-relativistic heavy-ion collisions, partons with intermediate energy (5-10) GeV excite ripples as they travel through the Quark-Gluon Plasma (QGP). These ripples' effect on particle production phenomenology is not very well studied. In this work, we extend our previous work and present study using a state-of-the-art hybrid framework that consists of the IP-Glasma pre-thermalization dynamics, viscous hydrodynamics (MUSIC), jet energy loss (MARTINI), and hadronic re-scatterings (UrQMD). This framework consistently handles both soft and hard physics involved in relativistic heavy ion collisions. The energy loss of mini-jets, whose energy is between 5 to 10 GeV, and their induced medium excitation are considered. The energy and momentum lost from the mini-jets are treated as either free-streaming wave-packets or causal diffusive perturbations of the hydrodynamic flow. They alter the energy-stress tensor evaluated on the particlization hypersurface during the hadronization as jet induced medium response. In addition, this approach uses a novel in-medium fragmentation, where the color neutrality of a string is enforced locally. We quantify the importance of the medium response from mini-jets propagation and their in-medium hadronization on identified particle p T -spectra and their flow anisotropic coefficients.


A 58-year-old male presented with dyspnoea and multiple drop attacks. He had left ventricular hypertrophy and strain on ECG ( Panel A ), and cardiomegaly on chest X-ray ( Panel B ). Echocardiography ( Panels C and D ; see Supplementary data online, Cine 1 ) showed severe biventricular non-obstructive hypertrophy with severely decreased LV function (EF 30%), restrictive filling pattern and small …


ABSTRACT Nine leafy vegetable crops were grown in outdoor sand plots to determine the effects of salinity and the timing of salt stress on leaf-ion concentration. Vegetable species were: radicchio (Cichorium intybus L.), curly endive (C. endivia L.), pac choi (Brassica rapa L., chinensis group), tatsoi (B. rapa L., narinosa group), kale (B. oleracea, acephala group), cooking greens (B. rapa L.), mustard greens (B. juncea (L.) Czerniak), spinach (Spinacia oleracea L.), and Swiss chard (Beta vulgaris L.). All species were planted at the same time and irrigated with a complete nutrient solution. Three weeks after planting, six saline treatments were imposed on half of the plants; the remaining plants were salinized four weeks later. Saline solution compositions were prepared to simulate the high-sodium, high-sulfate drainage waters typically found in the San Joaquin Valley of California. Electrical conductivities of the irrigation waters (ECi) were 3 (control), 7, 11, 15, 19, and 23 dS.m−1. Mineral ion concentrations in leaves were significantly affected by increasing salinity, but not by the stage of growth when salinity was applied. With increasing salinity, Ca2+ and K+ decreased in the leaves of all species, whereas Na+ and total-S significantly increased. Magnesium in leaves of the composites and the crucifers also increased with salinity, but treatment had no effect on Mg2+ concentration in the chenopods. Increases in salinity caused significant increases in Cl− in leaves of the crucifers and spinach but had no influence on the Cl− relations in Swiss chard and the composites. The use of moderately saline irrigation waters for the production of these leafy vegetable crops did not adversely affect crop quality as rated by color, texture and the mineral nutrient content available to consumers.


The ecotourism is an important way for the sustainable development of tourism.The author tries to analyze the Strength,Weakness,Opportunity and Threat of the development of ecotourism in Hexi Region by the analysis of SWOT.And then some developmental policies are thus made accordingly.


Genital candidiasis in adolescents is primarily associated with age-related features of the immune system. For the eradication of Candida spp. in adolescents with vulvovaginal candidiasis simultaneously with "Mikoflyu-150" immunomodulator «TAF» Lacto-Flor was used. The integrated antimycotic treatment with disease-modifying drug — «TAF» Lacto-Flor, showed 100% eradication of the pathogen, the normalization of clinical parameters and parameters of immune reactivity. The effectiveness of integrated treatment with «TAF» Lacto-Flor, safety and affordability, absence of complications allow to recommend the widespread use of this method in a complex therapeutic measures VVC in adolescent girls.


Status epilepticus (SE, prolonged seizures) is a common and serious clinical neurological emergency defined as 'a condition resulting either from the failure of the mechanisms responsible for seizure termination or from the initiation of mechanisms, which lead to abnormally, prolonged seizures'. Operationally, SE is defined as continuous seizure activity over 5 minutes or multiple seizures with incomplete return to baseline electroencephalogram activity between seizures. The annual incidence of SE is up to 41/100 000 with an overall mortality of about 20%.[1] Common causes of SE include noncompliance with anti-epileptic drugs (AED), stroke, metabolic abnormalities, or traumatic brain injuries.[1] First-line treatment usually includes the gamma-aminobutyric acid (GABA)potentiating benzodiazepines such as lorazepam or midazolam. If SE persists after first-line treatment, patients receive AEDs such as phenytoin, valproic acid, or levetiracetam. Failure of second-line treatment indicates patients have entered drugrefractory SE.[2] Data from experimental models and patients have shown that SE, in particular drug-refractory SE, can lead to widespread brain damage, gliosis, cognitive deficits, and an increased risk of developing epilepsy. Pharmacoresistance in SE patients remains as high as 43%.[2] This and the fact that prolonged seizure activity may lead to a decrease in available functional GABA receptors[2] emphasizes the need to develop new drugs with new mechanisms of action independent of GABA signaling. Research to identify new drug targets for the treatment of SE has shifted toward neuroinflammation and gliosis.[3] Astrocytosis may interfere with the clearance of extracellular neurotransmitters or with the extracellular levels of the anticonvulsive adenosine.[4,5] Indeed, a recent study showed that astrocytosis on its own is sufficient to trigger seizures in mice. [6] Activated microglia might also contribute to seizure generation and the resulting brain damage. In this context, particular interest has been on the pro-inflammatory cytokine Interleukin-1β (IL-1β). IL-1β has been shown to increase glutamatergic signaling and reduced GABAA currents[3,7] and targeting of IL-1β signaling has been reported to reduce acute seizures in animal models.[8] The involvement of glial cells as well as neurons in network hyperexcitability and the mediation of inflammatory processes modulating/increasing the release of neurotransmitters and pro-inflammatory cytokines implies that a fruitful approach to identify novel drug targets to treat SE could be to target genes which are expressed and function on both neurons and glia to influence communication and damage responses between these cells. Adenosine triphosphate (ATP), the main universal cellular energy currency, is also a key upstream trigger of neuroinflammation and a potential link between inflammation and hyperexcitability.[9,10] Usually present at very low levels in the extracellular medium, ATP levels rapidly increase during pathological conditions occurring during SE due to increased neuronal activity, inflammation, or cell death to act as either a sole transmitter or co-transmitter.[11] ATP can be released from neurons and glial cells in an uncontrolled fashion (e.g. during necrosis or from damaged cells) or via vesicular release. After its release, ATP is rapidly degraded by ectonucleotidases into breakdown products including adenosine.[9] Once released into the extracellular compartment, ATP activates metabotropic P2Y and ionotropic P2X receptors.[11] Both P2X and P2Y receptor subtypes are distributed throughout the central nervous system and are expressed and functional on glial cells as well as on neurons; however, controversy about the expression and function on different cell types for some receptors still remains.[11,12] P2X receptors have been associated with mainly facilitatory roles in fast synaptic transmission becoming most prominent during increased neuronal activity states by increasing Ca influx and potentially influencing the release of neurotransmitters. On the other side, P2Y receptors have been suggested to play a mainly inhibitory role on synaptic transmission.[11] Most SE studies to date have focused on the P2X receptor subtype; however, there is now also convincing evidence showing disease-contributing functions of the metabotropic P2Y receptor family in SE.[13] Whereas data on expressional changes have been reported for almost all P2 receptors after experimental SE, functional studies have been restricted to a rather limited number of receptor subtypes. This might be partly due to the lack of specific receptor agonists/antagonists or due to the lack of genetic models with a modulated receptor activity.[13] The P2X7 receptor has attracted most attention in SE. The P2X7 receptor has the lowest affinity to ATP (high μM to low


A series of poly(4-hydroxybenzoate-co-p-phenylene isophthalate)s (1) was prepared by melt polycondensation of 4-acetoxybenzoic acid, p-phenylene diacetate, and isophthalic acid followed by solid state polymerization. The thermal properties of the as-made samples were found to be significantly different from the second run thermal properties. The copolyesters with the same thermal history were annealed at 270°C in the DSC at various time intervals, and the thermal properties were further determined by DSC. For different compositions, annealing had different effects on the thermal properties of the copolyesters. With increasing annealing time the transition temperature and transition heat of 1 containing 50 and 60 mol-% of monomeric units (m. u.) of 4-hydroxybenzoic acid (HBA50 and HBA60) were found to increase. The second run DSC curves of HBA40, HBA30 and HBA20 (containing 40, 30 and 20 mol-% of 4-hydroxybenzoic acid m. u.) show two endotherms; transition heat and transition temperature of the lower temperature transition increase with the annealing time, but the transition heat of the higher temperature transition decreases. Finally, only one endotherm was observed for long-time annealing. The difference in thermal properties between the as-made sample and the second run could be described as annealing effect during solid state polymerization.


Objective To analyze the bacterial distribution of lower respiratory infection in patients with extracorporeal membrane oxygenation(ECMO) support after cardiac surgery and their drug.Resistance.Methods The clinical data of the patients who underwent cardiac surgery with the application of ECMO from January 2006 to October 2010 were retrospectively collected and analyzed.Results There were 116 strains of pathogenic bacilli isolated,which included Gram-negative bacteria(65.5%),Gram-positive bacteria(22.4%),and fungi(12.1%).The Gram-negative bacteria,such as baumanii,pseudomonas aeruginosa and enterobacter cloacae,showed multi-drug resistance.The Gram-positive bacteria including staphylococcus aureus,staphylococcus epidermidis and staphylococcus haemolyticus were more sensitive to vancomycin.The fungi including candida albicans and torulopsis candida were sensitive to fluconazole and 5-fluorocytosine.Conclusion The incidence of lower respiratory infection in postcardiotomy patients with ECMO is high,so it is important to take the operations under sterility strictly and use the antibiotics rationally to reduce the infection rate and mortality.


The invention provides a formant-frequency-based Mandarin single final voice visualizing method. The method comprises the following steps: framing and windowing an original voice signal; extracting short-time energy, formant frequency and fundamental tone frequency of each frame of signal; correcting errors of specific values of the formant frequency and the fundamental tone frequency by adoptinga median smoothing method; mapping different pronunciations into different color aspects by utilizing the formant frequency, and correcting; reflecting variation tendency of pronunciation time, energy and fundamental tone frequency in an image; and differentiating different Mandarin single final pronunciations by colors. The method is easy to implement by only extracting acoustic phonetic parameters of short-time energy, formant frequency and fundamental tone frequency of a voice signal; soft decision is introduced, each pronunciation is not subject to hard decision, but represented by different colors, and visualizing effect of different speakers on the same pronunciation is based on the principle of seeking common grounds while reserving differences, so that the decision on pronunciation more accords with subjective perception of people.


Morphological features including infiltrative growth, tumour budding (TB), and poorly differentiated clusters (PDCs) have a firmly established negative predictive value in colorectal cancer (CRC). Despite extensive research, the mechanisms underlying different tumour growth patterns remain poorly understood. The aim of this study was to investigate the involvement of epithelial–mesenchymal transition (EMT) in TB and PDCs in CRC. Using laser‐capture microdissection, we obtained distinct parts of the primary CRC including TB, PDCs, expansive tumour front, and the central part of the tumour, and analysed the expression of EMT‐related markers, i.e. the miR‐200 family, ZEB1/2, RND3, and CDH1. In TB, the miR‐200 family and CDH1 were significantly downregulated, while ZEB2 was significantly upregulated. In PDCs, miR‐141, miR‐200c, and CDH1 were significantly downregulated. No significant differences were observed in the expression of any EMT‐related markers between the expansive tumour front and the central part of the tumour. Our results suggest that both TB and PDCs are related to partial EMT. Discrete differences in morphology and expression of EMT‐related markers between TB and PDCs indicate that they represent different manifestations of partial EMT. TB seems to be closer to complete EMT than PDCs. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.


Humanity is increasingly urban. This statement is valid for Brussels as well as for most of the Occidental cities. By 2020, Brussels expects a raise of more than 170.000 inhabitants. This population growth should be considered with a concerning on urban models: What place for nature in these models? Densification and land use intensification tend on one hand to lead to a reduction of green cover. On the other hand, new inhabitants should be able to attend to more natural open spaces. Urban greenery is usually threatened by urbanization. However, green open spaces are also potentially public spaces where ecological functions are merged with urban open air uses. Presentation concerns a part of an ongoing PhD research whose methodology concerns analyses of twelve sites in Brussels Capital Region. Our methodology is based on four parts: -Analysing the status of these sites according to regional planning rules and regulation; -Analysing present and future urban pressure on sites; -Analysing green density inside and outside sites. We understand by green density, the ratio between green spaces and urban areas in terms of types, habits and uses. -Analysing relation between a site and the global urban system. This methodology should lead to suggest a classification according to their morphology, uses and their location. Results could represent a contribution to decision making system towards Ecocities.


Clifford algebra corresponds to Minkowski space. The coupling between real object particles and light quantum can be discussed by Minkowski space' s directional strangeness. A geometrical explanation for classical quantum theory is given by the introduction of Galilei transformation and Schrodinger equation into Minkowski space.


Fully conversant with the critical issues of the current cultural debates, Djelal Kadir goes to great pains to articulate and exercise the scruples with which critical reading and cultured scrutiny might proceed without unduly compromising otherness or capitulating the congeniality of reading and writing as civilizing activities.


Corrosion of steel reinforcement in concrete exposed to chloride containing environments is a serious problem in civil engineering practice. Electrochemical methods, e.g., potential mapping, provide information whether the steel reinforcement is still passive or depassivation has been initiated. By applying such techniques no information on the type of corrosion, its extent and distribution of corrosion products is available. Particular the corrosion progress is a significant problem. Especially in the case of macrocell corrosion in reinforced concrete structures, the development at the anode cannot be separated into corrosion damage resulting from macrocell corrosion or self‐corrosion. Until now also in laboratory tests it is impossible to collect such information without destroying specimens after electrochemical testing was performed. To overcome this problem it was tried to study the steel surface within the mortar specimens by X‐ray tomography (CT). Within the scope of these investigations it could be shown, that X‐ray tomography is suitable to make corrosion pits and their development visible which are embedded in a mortar with a cover thickness of about 35 mm. In this publication the time‐dependent corrosion damage of reinforced steel is documented by X‐ray tomography.


In a storage system 1, a storage apparatus A having a first pool 1430 including segments as unit storage areas and a storage apparatus B having a second pool 1430 having the same configuration are communicably connected to each other. In the storage system, an external volume identifier is associated with a logical volume 1420 included in the first pool 1430, the external volume identifier being used by a controller 1500 in the storage apparatus B to identify and manage the logical volume 1420 as an external volume 1425 that is a virtual volume in the storage apparatus B. Moreover, a volume identifier 5110 of the logical volume 1420 included in the first pool 1430 is rewritten into the external volume identifier in order to enable the storage apparatus B to utilize the logical volume 1420 created from the first pool 1430.


Introduction:
 The Seattle Proportional Risk Model (SPRM) is a validated model developed in systolic heart failure patients without implantable cardioverter-defibrillators (ICDs) to estimate the proportion of all-cause mortality (ACM) due to sudden death. This study aims to ascertain if SPRM has utility in risk stratification for secondary prevention ICD.

 Methods:
 The AVID (Antiarrhythmics Versus Implantable Defibrillators) trial was a multicenter, randomized clinical trial in which 1,016 patients presenting with ventricular fibrillation or sustained, symptomatic ventricular tachycardia were randomized to ICD or antiarrhythmic (AA) drug therapy. Using routine clinical variables, we applied the SPRM to patient-level data (n=995 with complete data) and assessed if the ICD benefit for ACM varied with SPRM-predicted probability of sudden death.

 Results:
 SPRM was predictive of sudden death vs. non-sudden death in patients without an ICD (logistic regression p=0.005). The ICD hazard ratio for ACM was 0.59. ICD survival benefit varied with SPRM for ACM (p=0.013) with benefit (ICD HR≤0.80) seen in patients with SPRM>40%. ICD benefit trended higher in patients with a history of heart failure (HF) vs no HF (HR=0.52 vs. 0.81, interaction p=0.13) (Figure 1). In comparison to the AA group, patients with either HF or SPRM>51% (median) had a meaningful ICD benefit (HR=0.60, p=0.017), and patients with both HF and SPRM>51% had the greatest ICD benefit (HR=0.38, p<0.001). There was no ICD benefit if no HF and SPRM<51% (HR=1.17).

 Conclusions:
 In a population of patients with VF or sustained VT, secondary prevention ICDs decreased ACM by 41%. ICD survival benefit varied with SPRM-predicted proportion of sudden death, and trended higher in patients with HF. SPRM may therefore provide a useful tool for risk stratifying patients for secondary prevention ICD.

 Figure 1:
 Survival benefit for ICD therapy varies with SPRM-estimated proportion of sudden death, and HF versus no HF.


miRNAs are important regulators of the translation of protein-coding genes. Their binding sites are located in all parts of mRNAs, but the features of localization r emain u nclear. The bi nding of 2, 036 h uman miRNAs with t he mRNAs of 12, 175 h uman g enes w as s tudied us ing t he m iRTarget pr ogram, which was developed in our laboratory. It was predicted that miR-619-5p, miR- 5095, miR-5096 and miR-5585-3p bind with high affinity to the mRNAs of the 1215, 832, 725 and 655 genes, respectively. miRNAs binding sites are located in the 3'-UTRs, CDSs and 5 '-UTRs. The m RNAs of s ome g enes h ad multiple miR-619-5p, mi R-5095, miR-5096 and miR-5585-3p bi nding s ites. T he m any predicted target genes are participants of cell cycle and apoptosis. The possible functional pr operties of miR-619-5p, mi R-5095, m iR-5096 a nd m iR-5585-3p are discussed.


4-(1-Phenylethyl)-1,3-resorcinol was synthesized by the Friedel-Crafts reaction using resorcinol and styrene as raw materials and ionic liquid N-methyl pyrolidone bisulfate salt([Hnmp]HSO4)as the catalyst,.The optimum reaction conditions were obtained by orthogonal experiment program as follows:the molar ratio of n(resorcinol)∶n(styrene)was 1.5∶1.0,the dosage of catalyst [Hnmp]HSO4 was 2.5%,the reaction temperature was 105 ℃,and the reaction time was 6 h,with toluene being used as the solvent.The overall product yield was 85.7%.The structure of product was determined by melting point measurements,IR spectrometry,ESI-MS spectrometry and 1HNMR spectrometry that were applied to verify the target product.


The study was conducted to investigate the effects of coppers on performance and apparent deposit rate in broilers.A completely randomized experiment was designed for 224 one-day broilers,which were randomly divided into four treatments adding Cu 0,8,150,225 mg·kg-1,each treatment with four replicates,and each replicate with 14 broilers (seven male:seven female).The results showed that dietary copper levels (8 mg·kg-1) significantly increased both performance and apparent deposit rate of crude fat during the whole period (P0.01).Group with Cu 50 mg·kg-1 significantly increased apparent deposit rate of crude protein (P0.01);No sumplementation with copper (0 mg·kg-1) significantly reduced feed/gain ratio at the later stage (P0.01).High dietary copper levels (150 and 225 mg·kg-1 diet) suppressed performance and crude fat extract apparent deposit rate significantly through the whole period.From 0 to 4 weeks,the suitable dietary Cu supplementary level was 8 mg·kg-1,and from 5 to 7 weeks was 0-8 mg·kg-1.


This quasi experimental study was conducted to determine the results of clinical nursing guideline for discharge planning in chronic obstructive pulmonary disease patients receiving treatment at Kantang Hospital, Trang Province, measured by recurrence in 28 days of patients. The samples were chronic obstructive pulmonary disease patients recruited from 3 wards including male ward, female ward, and special ward admitted between January and September, 2016. Research instruments for data collection included general information form and treatment form which consisted of discharge planning guideline using D-METHOD criteria. Data were analyzed using frequency, percentage, Pearson Chi-Square test. The study found that 161 patients in the age range of 32-87 years were mostly patients in the age group of 41-60 years, 83.2 percent, male 85.1 percent, and 88.8 percent married. 87.0% did not work, 67.7% length of stay, less than 3 days, 64.0%. The disease duration was more than 10 years, the highest over 10 years was 50.3%. Get 27.3% of new cases of patients with chronic obstructive pulmonary disease who received discharge planning less than not get it 72.2%. The old cases patients who were received discharge planning more than not get at 54.0% and readmitted in 28 days, and news cases did not readmitted in 28 days, and found no difference in the patients who are and are not received discharge planning . It was not statistically significant at 0.05.


The LUT based VerilogA model for Depletion (D) mode AlGaN /GaN HEMT has been used to simulate the parameter of RF switch in Cadence. The incorporation of device's measured data in Cadence for a circuit level designing, has been possible via this LUT based VerilogA model. This procedure has shown a way to incorporate a novel devices in a circuit level design. The results can be concluded as isolation and insertion loss of a RF switch is 240 to 235 dB and 20.5 to 22.5 dB, respectively at optimized biasing conditions, that is, Vd 5 10 V and Vg 5 21 V. Thou there are few issues with the predictability and scalability of this LUT based VerilogA model, but, it incorporates real time responses of typical GaN HEMT devices. The correlation of present model with device physics needs further explorations.


The utility model discloses large-sized vehicle distance measurement equipment for a dangerous source point of a power transmission and distribution line. The equipment comprises two cameras arranged in the site of the dangerous source point of the power transmission and distribution line. The shooting ranges of the two cameras are overlapped and the two cameras have different shooting positions. The two cameras are connected with a video analysis server through a wifi and wireless router and transmit acquired images to the video analysis server. The video analysis server is connected with a mobile phone of management personnel through a 3G network in a short message communication mode. The large-sized vehicle distance measurement equipment has a reasonable structure and detects the distance from a large-sized vehicle to a high-voltage tower continuously through the cameras without needing artificial measurement. The large-sized vehicle distance measurement equipment can realize real-time and uninterrupted measurement, and give out on-site short message alarms for safe distances with potential safety hazards.


Previous research has shown that children and adults express more confidence in the existence of unobservable scientific (e.g., germs), as compared to religious, phenomena (e.g., the soul). We asked if the same pattern would emerge among parents (N = 77) and children (N = 85) in Iran, a country with widespread commitment to religious values and beliefs. Parents expressed confidence in the existence of various scientific and religious phenomena but were more confident that scientific phenomena exist. Moreover, even though Iranian parents expressed a high valuation of both science and religion, their valuation of science was higher than that of religion. Like their parents, older children also expressed greater confidence in the existence of scientific, as compared to religious, phenomena. We conclude that with age, the kind of discourse children are exposed to elicits more confidence in the existence of scientific phenomena even in a religious society.


Colonoscopy is a common and relatively safe diagnostic and therapeutic procedure. Iatrogenic complications are rare but have been reported in the medical literature. The most common complications are colonic perforation (0.1%2.67%) and hemorrhage (0.001%-0.72%), often associated with biopsy or polypectomy [1, 3]. Other rare complications include bacteremia, ileus, mesenteric tears, pneumothorax, pneumoperitoneum, pneumoscrotum and colonic volvulus [2, 4].


In our previous research, the modified Galerkin method was proposed as one of the most efficient methods for the analyses of convection-diffusion problems and two-dimensional viscous fluid flow problems. In this modified Galerkin method, the inertia term is considered explicitly, so only the symmetrical matrixes appear. Then an artificial viscosity is introduced through an error analysis approach to improve its accuracy and stability. In this paper, we proposed a new finite element formulation for three-dimensional incompressible viscous fluid flow analysis. This formulation ('MS' algorithm and 'MSR' algorithm) is based on the modified Galerkin method coupled with the Semi-Implicit Method for Pressure-Linked Equations. The cubic cavity flow problems were investigated for the Reynolds number of 400, 1,000, 2,000 and 3,200 using non-uniform meshes. Finally, we confirmed the effectiveness of our proposed method through the comparison with other research works.


It has been suggested that a periodical two-layered medium might by considered as the simplified model of wave propagation in cancellous bone. In the present paper an approach is proposed to describe a one-dimensional problem of wave propagation in the cancellous bone modeled as a randomly layered material composed of two kinds of alternating elastic layers having randomly distributed thicknesses and different acoustic properties. A compact form of the dispersion equation and the relationships for reflection coefficients and acoustic impedance of the randomly layered medium is obtained. The wave parameters are functions of acoustical properties of the layers and the distributions of their thicknesses. The obtained equations are used to derive the analytical expressions for three special cases: for long waves; for a periodic medium composed of layers of constant thicknesses; and for random medium characterized by uniform distribution of layer thicknesses. Special attention is paid to the frequency analysis of the wave parameters characterized by strong and weak acoustic inhomogeneity. It is shown that although the developed model is a rough simplification of the cancellous bone architecture, it has potential for future research, particularly for higher frequency range, when the scattering effects play the predominant role in wave attenuation.


This document arises as a research product that, motivated by the concerns of the authors' teaching practice, is also framed in the results obtained by the students of the District Educational Institution Ofelia Uribe de Acosta (hereinafter IED Ofelia Uribe de Acosta) , in the Saber 2016 Test, in particular to the problem solving component; and that raised questions about the way in which the teaching processes are developed, and therefore learning, within the classrooms, and about the importance of this component, which has been involved in significant situations in such a way that allow the student a better approach to its context. Today, the process of solving problems focuses on algorithmic methods, lacking in meaning, and which are subsequently forgotten, hindering the continuous transfer of knowledge to the different situations faced by the student in his daily life. That is why it is necessary to observe, analyze and understand the ways in which teachers teach and students learn about solving problems in the field of mathematics, is the route by which they can establish certain didactic strategies that strengthen this process. For this reason this study focuses on observing the processes used by students for the resolution used by students in terms of additive problems, specifically those corresponding to the compound type for which a sample classified according to their level of performance (low, medium, high), to which an initial or diagnostic test is applied and a final or exit test. In addition, semi-structured interviews are conducted, each one after the previous tests; in such a way that they allow interpreting and understanding about how they assume and solve the additive problems 13 of the compound type; this in order to generate a change in the didactic sequence, which, with varied contexts that involve semi-structured and structured situations, allowing a cooperative and collaborative work. Thus, later, establish an intra-subject and inter-subject analysis and from there establish regularities and particularities, work with which in the end it tends to improve the performance of students in this aspect. For this, international, national and experimental research is resumed. in this field, in order to support the importance of the processes of solving additive problems of compound type, used by students and from there to consider the categories of analysis of this work.


ABSTRACT Experimental results of fluidized bed paddy drying using high inlet air temperatures (140 and 150 °C) showed that head rice yield could be increased to a maximum value at a range of paddy final moisture contents of 19 to 22 % wet-basis. In case of reducing moisture content of paddy to lower than 19 % wet-basis, head rice yield of tempered paddy was higher than that of no-tempered one. Initial moisture contents of paddy that could increase head rice yield were in a range of 23 to 31 % wet-basis. As initial moisture content increased head rice yield increased. Whiteness of dried paddy was mostly accepted. However, if tempering temperature was higher than 60 °C, it may cause the problems for trade.


An apparatus for upmixing a downmix audio signal describing one or more downmix audio channels into an upmixed audio signal describing a plurality of upmixed audio channels comprises an upmixer and a parameter determinator. The upmixer is configured to apply temporally variable upmix parameters to upmix the downmix audio signal in order to obtain the upmixed audio signal, wherein the temporally variable upmix parameters comprise temporally variable smoothened phase values. The parameter determinator is configured to obtain one or more temporally smoothened upmix parameters for usage by the upmixer on the basis of a quantized upmix parameter input information. The parameter determinator is configured to combine a scaled version of a previous smoothened phase value with a scaled version of an input phase information using a phase change limitation algorithm, to determine a current smoothened phase value on the basis of the previous smoothened phase value and the phase input information.


Over the past decade, crowdsourcing has emerged as a cheap and efficient method of obtaining solutions to simple tasks that are difficult for computers to solve but possible for humans. The popularity and promise of crowdsourcing markets has led to both empirical and theoretical research on the design of algorithms to optimize various aspects of these markets, such as the pricing and assignment of tasks. Much of the existing theoretical work on crowdsourcing markets has focused on problems that fall into the broad category of online decision making; task requesters or the crowdsourcing platform itself make repeated decisions about prices to set, workers to filter out, problems to assign to specific workers, or other things. Often these decisions are complex, requiring algorithms that learn about the distribution of available tasks or workers over time and take into account the strategic (or sometimes irrational) behavior of workers.
 As human computation grows into its own field, the time is ripe to address these challenges in a principled way. However, it appears very difficult to capture all pertinent aspects of crowdsourcing markets in a single coherent model. In this paper, we reflect on the modeling issues that inhibit theoretical research on online decision making for crowdsourcing, and identify some steps forward. This paper grew out of the authors' own frustration with these issues, and we hope it will encourage the community to attempt to understand, debate, and ultimately address them.


Abstract The crystal structure of the title compound, C17H13N5O4, has been determined by single crystal x-ray diffraction at room temperature. The molecule is not planar, with dihedral angles of 7.2(1)° between the quinoline ring and N-methylhydrazone group, and 17.45(2)° between the N-methylhydrazone group and the phenyl ring. The crystal parameters of this compound are as follows: monoclinic P 21/n, a=9.525(2)A, b = 15.192(2) A, c = 11.302(2) A, β = 94.722(3)°, V = 1629.8(6) A3, Z = 4, Dx = 1.432 g/cm3, F(000) = 728, λ (MoKα) = 0.71070 A, μ = 0.106 mm−1, Rint = 0.017. The structure was solved by SHELXS-86 and refined by SHELXL-93. R = 0.07 for 2438 observed reflections with I > 2σ (I).


Plants belonging to the Eupatorium species, E. japonicum Thunb, E. fortunei and E. chinense, were found to contain very low concentrations of pyrrolizidine alkaloid compared with a known hepatotoxic Indian herbal mixture and Crotalaria assamica. High concentrations of pyrrolic metabolite were detected in livers of mice given a single oral dose of extracts of Indian herbal mixture or C. assamica but not in the case of the Eupatorium species. Also, accumulation of pyrrole metabolites was not demonstrated with chronic administration of decoctions prepared from herbs of the Eupatorium species.


The abstract of the report examines the legislative framework in the UK on the use of IT technologies in law enforcement.


are some examples: • Children with spina bifida self-model their swimming skills on video, then later watch the videotape to reinforce the skills. • Students preparing for inclusion view a video of the general classroom in action, including the teacher's instructions, their new peers' conversations, and a review of classroom rules. • A teacher prepares her students for reading Romeo and Juliet by showing and discussing a video of West Side Story. • Students record examples of good classroom behavior on videotape and then play them back, discussing rules and natural consequences. • A teacher makes video portfolios of students' progress over the year and shares the results with the parents. Though videos and videocassette recorder (VCR) technology can facilitate the development of a variety of academic and social skills, the use of VCR technology in classrooms is often confined to recording and viewing a television show or an activity (Peelle. 1982). In light of the widespread availability of VCR technology in schools and homes and the potentially diverse uses of VCR technology, the purpose of this article is to provide special educators with suggestions for using VCR technology in their programs. The extent to which educators can use these VCR-based strategies with their students will depend on the developmental levels and ages of their students. Most of the strategies can be modified for younger or older students, but educators should consider the cognitive and language demands associated with each strategy. Educators also should tailor the suggestions offered to the unique characteristics of their educational settings. ,. w


BACKGROUND
The residency program for a specialist in orthopedics and trauma surgery is facing fundamental changes based on an initiative originating from the working group "medical training" of the German Medical Association (GMA). A survey indicated that 50 % of all trainees are dissatisfied with their current situation. It appears important to integrate the ideas and wishes of current orthopedic residents in a novel training concept. To assess this a survey was performed by the Young Forum of the German Society for Orthopedics und Trauma Surgery.

MATERIAL AND METHODS
The internet-based short survey was conducted in January 2013 among members of the professional societies (DGU, DGOU and DGOOC). 408 physicians participated.

RESULTS
The majority of the participating physicians is interested in a career in orthopedics and trauma surgery with primarily operative contents. Accordingly the majority (62 %, n = 253) voted against a reduction of numbers of surgical interventions with 86 % (n = 351) confirming the necessity that these operations must be carried out by the trainee himself.

CONCLUSION
The upcoming changes in residency program for orthopedics and trauma surgery offer the opportunity for a well structured and practical oriented residency program. It could be a further step in increasing satisfaction in this profession.


As a graduate student at Brown University (∼1978), this researcher was very fortunate to have met Joe Blue at Acoustical Society meetings. As I had little knowledge of the members in the society and an extremely limited grasp of the practical technology behind nonlinear acoustics, Joe was extremely friendly and took the time to answer a long list of questions about nonlinear underwater transducer designs with applications to the parametric array [Muir, T.G. & Blue, J.E. ''Experiments on the acoustic modulation of large‐amplitude waves,'' J. Acoust. Soc. Am. 46, 227–232 (1969)]. This influenced this researcher's Ph.D. thesis involving experiments on the scattering of sound by sound in the presence of turbulence. Recently, experiments on the nonlinear acoustic detection of buried landmines [Korman, M.S. & Sabatier, J.M., ''Nonlinear acoustic techniques for landmine detection,'' J. Acoust. Soc. Am. 116, 3354–3369 (2004)] has brought some attention to understanding the difference between classical and nonclas...


The design scheme of variable structure control for discrete-time systems is considered. Due to the shortcoming of discrete exponential reaching law which can not push the system state approach to zero but induce oscillation, a new discrete reaching law is presented to improve the reaching process of discrete exponential reaching law via using saturation function to replace sign function. The discrete-time variable structure control system designed by this reaching law can not only weaken the chattering and push the system state approach to zero gradually, but also keep the basic property of quasi-sliding mode which can cross the switching surface step by step. This method improves the reaching process and enhances the control quality of the discrete-time variable structure control system. The simulation results validate the feasibility and reasonability of this method.


We analyze spectral properties of a class of integral-difference collision operators arising in some nonequilibrium statistical physics models. We present analytical estimates and numerical results for the operators defined on finite intervals and corresponding to the truncated Gaussian equilibrium distribution function. Some conclusions are drawn about the spectrum of operators on whole axis. Physical limitations for these kinds of models are discussed.


This paper presents a method for prediction of uncertain closed loop systems, where the uncertainties are depending on operating points. Such model uncertainties are often present when complicated non-linear systems are predicted. The method uses precomputed mean and variances of the prediction error depending on the operation point given by references and disturbances. These uncertainty models are stored in a model bank, linear interpolation is applied to the elements of the model bank in order to predict uncertainty bounds on the predictions using the statistics of the past prediction uncertainties. It is as well proposed to update the uncertainty prediction models on-line. The potential of the method is illustrated by an example from a coal-fired power plant. This example shows prediction of the uncertainties as a bounded region in which the given system variable can be assumed to be contained in. In the example these successfully bound the system variables while in comparison applying a simple prediction diverges from the system.


Summary The data presented indicate that glutamine remained stable when prepared in citrate or aqueous solution, stored at 4°C for at least 8 weeks or at room temperature for 3 to 4 weeks. Analyses of deproteinized plasma indicate that the glutamic acid concentrations were constant and stable for approximately 4 weeks. Plasma glutamine determinations were also quantitatively reproducible with time. These results would also suggest that with deproteinization of blood, the values obtained for glutamic acid are not due to glutamine breakdown but are true glutamic acid values. Addendum: Since submitting this manuscript, it has been demonstrated that there is no significant increase in ammonia concentration in samples analyzed for one week from a plasma filtrate.


Analysis of stress-strain state redistribution is one of the basic factor in investigation of manual interaction of the underground openings. Mentioned interaction is especially characteristics for long nail mining, where it can reach more then 50 m in front of the long wall face. Stress-strain distribution around the long wall and its influence on existed mining opening was analyzed in this paper. In the second pad of paper interaction of supports and sorrounding rock massif of existing opening was investigated taking into account new stress-strain state caused by approaching of the long wall face. .


Objective To investigate the effect of Triptolide and Paclitaxel on the activity of drug-resistant ovarian cancer cell(CoC1/DDP cells)in vitro and its possible mechanism.Methods The CoC1/DDP cells in exponential phase of growth were divided into four groups randomly,the TP group was treated by TP(10 ng/ml),the paclitaxel group was treated by paclitaxel(3.13 μg/ml),the combined group was treated by TP(10 ng/ml) and paclitaxel(3.13 μg/ml),the control group was given no treatment(zero group).MTT assay was used to detect the cell growth inhibition rate of each group,transmission electron microscope was used to observe the change in cell ultrastructure of CoC1/DDP cells,the proportion of cell cycle and the apoptic ratios of CoC1/DDP cells were measured by flow cytometry.Results The growth inhibiting rate of CoC1/ DDP cells of combined group was significantly higher than that of TP group and paclitaxel group,in time-dependent manner(P0.05);apoptotic cells could see in TP group,paclitaxel group and combined group under transmission electron microscope,the apoptic ratio of CoC1/DDP cells of the combined group was significantly higher than that of the single-drug group(both P0.05).The proportion of G2/M phase of CoC1/ DDP cells increased obviously in paclitaxel group and the combined group(P0.05).Conclusion There is a synergistic effect when triptolide and paclitaxel are used together to inhibit the growth and induce poptosis of CoC1/DDP cells,the mechanism may be associated with blocking cell cycle in G2/M phase.


Present work is focused on the performance analysis of power cartridge system. Firing tests are performed in a variable volume test chamber. In the experiments, the current level, the main propellant, intermediate and primer charge types, quantities are varied. Ignition delay time was found to be decreasing with higher current level and more sensitive primer charge. The similar results were found for the required time to reach maximum pressure level. The maximum pressure level was also increasing with current level and quantity of the main charge. The quantities of primer and intermediate charge had been found to have small effect on the pressure level. Some discrepancy in the experimental data was found to be result of incomplete combustion which might be due to packing conditions. Pressure distribution in the tests chamber is obtained from the numerical solution. It is seen that due to the flow shocks the highest pressure level in the chamber is the farthest point from the cartridge explosion.


Using reverse osmosis high-salinity-water as flushing the toilet water,the flushed high-salinity-water was treated biochemically.The test results showed that as the electrical conductivity of reverse osmosis high-salinity-water was lower than 1500 s,the microorganism in biochemical system should not be affected.The experiment gives scientific prop for chemical engineering wastewater zero release and circular economy.


Propagation of Antholyza (Chasmanthe aethiopica (L.) N.E Br.) by seeds, usually needs 3-4 years to get flowering plants, and may be accompanied with some genetical isolations. However, in order to keep the quality and colour of the cultivated species, it is preferable to use new corms or cormels in propagation. Increasing such new corms or cormels on the mother plant is considered the main target from the commercial point of view. So, a field trial was carried out at Orman Botanical Garden, Giza, Egypt during 2005-06 and 2006/07 seasons to study the effect of kinetin (6-furfuryl aminopurine) at the levels of 0, 25, 50 and 75 ppm, kristalon (a complete fertilizer of 19:19:19 + micronutrients) at the rates of 0, 1, 2 and 3 g/L and the combination between 50ppm kinetin and 2 g/L kristalon on the vegetative growth, flowering, corms productivity and chemical composition of Chasmanthe aethiopica (L.) N.E. Br. Plants. The obtained results indicated that all treatments, except for 1 and 3 g/L kristalon, improved plant height and fresh and dry weights of leaves, with the superiority of the combined treatment which significantly gave the longest plants and the heaviest fresh and dry weights. Number of leaves/plant, however was not affected by either treatments used in such study. The best flowering precocity and quality of spikes (assessed as flowering stalk length, No. florets/ spike and vase life) were found to be the best in case of the combined treatment, which also gave the highest number and best quality of cormels/ plant, the highest content of pigments in the leaves (specially chlorophylls a and b), the best balance between promoters (as indoles) and inhibitors (as phenols), as well as the percentage of total carbohydrates, N, P and K in the leaves and corms of treated plants. Hence, it is recommended to spray the foliage of Chasmanthe aethiopica (L.) N.E. Br. plant till run off with the combination of 50ppm kinetin and 2 g/L kristalon after planting the corms by about 50 days, thrice with three weeks interval for best growth, flowering, corms productivity and chemical composition.


--- The leadreship of the principal in an eduactional institution and the
communicative competences between the educational community has a
great importance in the interpersonal relationships, positive institutional
climate and therefore in the institutional success.
This invetigation is of cuantitative type, of co relational descriptive
level, that consists on analyzing the relationship betwwen the variables of the
kind of leadership and the styles of communication; the design is Non
experimental of transversal nature.
According to the objectives of the investigation, it is considerated that
the kind of leadership of the principal is related to the styles of
communication of the teachers, students and of the administrative staff.
According to the analyzis of correspondences of the variables, there is
a significative association, the statistical chi-cuadrado (40.086) with a value
of significance minor to 0.05 supports this conclusion.
We conclude tha there is a significative relationship, with a grade of
correlation of 0,524 and a level of significance minor to 0.05, between the
kind of liberal leadership of the principal and the passive style of
communication.
As well, there is a significative relationship between the the kind of
authoritary leadership of the principal and the agressive style of
communication in a grade of correlation of 0,671 and a leve of significance
minor to 0.05.
Finally, we conclude that there is a significative raltionship between
the kind of democratic leadership of the principal and the assertive style of
communication in a grade of correlation of 0,558 and a level of significance
minor to 0.05.


Electroweak second order shifts of muonium ($\mu^+e^-$ bound state) energy levels are calculated for the first time. Calculation starts from on-shell one-loop elastic $\mu^+ e^-$ scattering amplitudes in the center of mass frame, proceed to renormalization and to derivation of muonium matrix elements by using the momentum space wave functions. This is a reliable method unlike the unjustified four-Fermi approximation in the literature. Corrections of order $\alpha G_F$ (with $\alpha \sim 1/137$ the fine structure constant and $G_F$ the Fermi constant) and of order $\alpha G_F /(m_Z a_B)$ (with $m_Z$ the Z boson mass and $a_B$ the Bohr radius) are derived from three classes of Feynman diagrams, Z self-energy, vertex and box diagrams. The ground state muonium hyperfine splitting is given in terms of the only experimentally unknown parameter, the smallest neutrino mass. It is however found that the neutrino mass dependence is very weak, making its detection difficult.


BACKGROUND: Using the recent Consensus Panel recommendations, we sought to describe the incidence of transfusion‐related acute lung injury (TRALI) and transfusion‐associated circulatory overload (TACO) in critically ill patients.


Keywords: Weighted tree – resource discovery – bitmap – cluster computation – ultra large scale system (ULSS) Recently Software Engineering Institute has presented the Order of America Department of Defense as associated with the development of IT. The office of the Assistant Secretary of the U. S. Army funded the Software Engineering Institute to lead a report on the current challenges of ultra-large-scale (ULS) systems software. There are many heterogeneous resources in the ULS which are distributed geographically. resources discovery that satisfy users " requests, is an important task. In This paper strengths and weaknesses of techniques for resource discovery is evaluated. We compare our algorithm with previous algorithms using simulations and results and show that the number of nodes visited in our resource discovery algorithm is less than that for other algorithms.


Incubation of rat brain synaptic membranes at pH 5.0 for 2 to 3 h resulted in the release of 20 to 25% of sialic acid associated with both membrane glycoproteins and gangliosides. In contrast, SO to 60% of glycoprotein and ganglioside sialic is hydrolyzed by exogenously added neuraminidase. Hydrolysis of sialic acid by neuraminidase or intrinsic sialidase resulted in SO and 14% decreases in synaptic membrane wheat germ agglutinin (WGA) receptor activity, respectively. Binding of concanavalin A was not affected by sialic acid hydrolysis, Preincubation of membranes with WGA resulted in a 70 to 80% decrease in the subsequent hydrolysis of glycoprotein sialic acid by either neuraminidase or intrinsic sialidase. WGA did not affect hydrolysis of ganglioside sialic acid by neuraminidase but produced a 25 to 30% increase in intrinsic ganglioside:sialidase activity. Concanavalin A did not alter hydrolysis of glycoprotein siallc acid by neuraminidase, although it did result in some inhibition (30%) of intrinsic activity. Identification of receptors for WGA following electrophoresis of membrane proteins on polyacrylamide gels showed that, whereas all molecular weight classes of WGA receptors were acted upon by neuraminidase, intrinsic sialidase selectively hydrolyzed sialic acid from glycoproteins with apparent molecular weights in excess of 70,000.


In this paper we present computer calculations and measurements of the 2200 m/s neutron flux in two different phantoms irradiated in the treatment port of a prototype moderator assembly for an accelerator-based neutron source (ABNS) for boron neutron capture therapy (BNCT). The 2200 m/s flux (φ 0 ) is a useful quantity, because it is proportional to the boron absorbed dose rate in phantom. The results of the calculations and measurements are compared at several locations in head phantoms. When S(α, β) cross sections for hydrogen are used, along the beam centerline, the calculations agree with measurements with average deviations of plus 7%, for a rectangular parallelepiped water phantom, and minus 6%, for a polymethylmethacrylate (PMMA) ellipsoidal phantom.


Reaction of highly substituted dithiobenzoates 1 (a-e) with chloramine-T in methanol at 20°C gives, in high yields, thione S-imides 2 (a-e) to which the E-geometry was assigned. Heating of these compounds in methanol for 1 hr causes thermodynamic isomerization to the Z-isomers 3 (a-e). Similarly, 2,4,6-trimethyl-thiobenzophenone gives the corresponding E- and Z-S-tosylimides 6 and 7. Irradiation of thione S-imides 2, 3, 6 and 7 leads to extrusion of sulfur yielding N-tosylimines 4 and 8. The geometrical configurations were based on ASIS experiments. From the 1H-NMR spectra of 2 and 3 the preferred conformation of the thione S-imides have been deduced (S-trans conformation for the E-isomer 2 and a folded S-cis conformation for the Z-isomer 3). It will be shown that in order to obtain stable thione S-tosylimides from dithiobenzoates and thiobenzophenones, steric hindrance in the direct environment of the thiono function is a prerequisite.


The invention provides an injection molding method for in-mold decoration, comprising the following steps: step (1). A pattern is painted on a thin film so as to form a pattern surface; step (2). The thin film is led to form a preset shape; step (3). A reinforcing layer is coated and molded on the pattern surface of the thin film; step (4). The pattern surface and the reinforcing layer of the thin film are coated with glue so as to form an adhesive coating; and step (5). The thin film is placed into an injection molding mold which has a material-running channel and the reinforcing layer of the thin film faces the material-running channel; and step (6). Liquid plastic is injected into the mold by the material-running channel so as to produce a finished plastic product, one surface of which is provided with the pattern. Therefore, the method has the functions of being capable of reducing crack phenomenon on the surface of the finished product and reducing the fraction defective of the finished product and environmental pollution and the like.


The Spectr-W3 information-reference system was developed in 2001-2013 and realized as an online Web resource based on the factual atomic database Spectr-W3. The information accumulated in the Spectr-W3 atomic database contains about 450,000 records and includes the experimental and theoretical data on ionization potentials, energy levels, wavelengths, radiation transition probabilities, and oscillator strengths, and the parameters of analytical approximations of electron-collisional cross-sections and rates for atoms and ions. Those data were extracted from publications in physical journals, proceedings of the related conferences, special-purpose publications on atomic data, provided directly by authors. The information is supplied with references to the original sources and comments, elucidating the details of experimental measurements or calculations. To date, the Spectr-W3 atomic database is still the largest factual database in the world, containing the information on spectral properties of multicharged ions. In 2014, the new stage in the development of the Spectr-W3 atomic database started. The purpose of this stage is the creation of a new information section of the Spectr-W3 database. This section would contain the information on the x-ray emission spectrograms registered from various plasma sources.


This document describes the system built by the SPL-IT-UC team from the Signal Processing Lab of Instituto de Telecomunicações (pole of Coimbra) and University of Coimbra for the Query by Example Search on Speech Task (QUESST) of MediaEval 2015. The submitted system filters considerable background noise by applying spectral subtraction, uses five phonetic recognizers from which posterior probabilities are extracted as features, implements novel modifications of Dynamic Time Warping (DTW) that focus on complex queries, and uses linear calibration and fusion to optimize results. This year's task proved extra challenging in terms of acoustic conditions and match cases, though we observe the best results when merging all complex approaches.


Based on the forming and loading principles of multi-stranded wire helical spring,the article firstly pays more attention to the state distributing of the contact facet. With the help of predecessors' work, the novel model then divides the facet into three zones, which including spacing zone, spring zone and friction zone. On further more research, it analyses the boundary and contact judgment quantitative conditions under the coordination of the Normal-P_tangent-Tangent , respectively.


Based on ethnographic fieldwork conducted in Seoul from July 2012 until July 2013, this dissertation offers a novel perspective on human-animal interactions and public discourses regarding livestock versus pet moral boundaries in contemporary Korea. I aim to explore how Koreans struggle to make sense of the tension between the emergence of animal welfare and the perpetuation of traditional health behaviours that involve animal processing. The focus will be on why participants in my study, whether activists or not, defended both animal ethics and cat and dog meat consumption, while including Korean animals in fluid and instrumental conceptions of Koreanness. I have analysed a variety of discourses produced by both Korean and non-Korean, academic and non-academic stakeholders, in order to reveal the on-going tension between these powerful ubiquitous ideas and the lived experience of Koreans today. Moreover, I examine how the aesthetics of cruelty and empathy is employed in order to singularize livestock into companion animals thereby transgressing cultural taboos regarding Western ethics of species separation. I also demonstrate that converging and conflicting economic, political, social and cultural agendas are responsible for making Korea's public discourses about animal welfare very unsettled. My research thus contributes to key anthropological debates about the cross-cultural circulation and cross-fertilisation of moral values that impact the ethics of post-industrial human-animal interactions; and about the influence of policy dialogue, at both national and international levels, on applied animal ethics, cultural stigmatization and the reinforcement of national sentiment.


The specific retention volumes are reported of several alkane solutes on five poly(methylphenylsiloxane) (PMPS) stationary phases with different methyl/phenyl proportions at temperatures within 30-95-degrees-C. The amounts of polymers in the columns employed have been determined by elemental analysis of the column packings. The methyl/phenyl proportions in the siloxane polymers have been obtained by NMR spectrometry. The activity coefficients and interaction parameters of the solutes at infinite dilution in the PMPS samples have been calculated from the specific retention volumes. From the activity coefficients and interaction parameters, the partial molar excess enthalpies of the solutes (DELTA-HBAR1E infinity) and the polymer solubility parameters (sigma-2) have been obtained. The effects of temperature and polymer composition on the values of DELTA-HBAR1E infinity and sigma-2 are discussed.


Abstract— The hight social problems that exist in the city of Cirebon, make the Sosial Service Empowerment of Women and Chilidren of Cirebon City design a community service program that is the Cirebon Confession Contest. In order for the Cirebon Confession Contest to run smoothly, it needs the support of the community. Before that the public first understand the Cirebon Confession Contest program. Socialization is way to make people understand the Cirebon Confession Contest program. The theory used in this reserch is Hafied Cangara's communication planning theory with a "?" sign flow pattern with Assifi and French. The purpose of this study was to determine the uniqueness of the Cirebon City Sosial Service communication planning in socializing the Cirebon Confession Contest program. The uniqueness of the Cirebon City Social Service communication planning in socializing this program by socializing every Sunday on Car Free Day or the Bima Stadion. The resercher obtained the results of the research that the communication planning carried out by the Cirebon City Sosial Service was in accordance with the communication planning of the sign flow model "?" Hafied Cangara with Assifi and French.  In carrying out each program there are obstacles that are encountered, the obstacles that exist in the Cirebon City Social Service in conducting socializing are people who do not know the information about the Cirebon Confession Contest program. The research method used is qualitative research with a case study approach, collecting data through interview, observations and documentation. Keywords: Cirebon Confession Contest, Comunnication Planning, Socialization


PURPOSE
We validated externally the predictive accuracy of the 2001 Partin tables and compared the 1997 and 2001 versions.

MATERIALS AND METHODS
We used ROC derived AUC to test the predictive accuracy of organ confinement (OC), extraprostatic extension (ECE), seminal vesicle invasion (SVI) and lymph node involvement (LNI) of 1997 and 2001 Partin tables derived probabilities. These probabilities were defined by the pretreatment clinical stage, serum prostate specific antigen and biopsy Gleason grade of 2,139 patients treated with radical prostatectomy for clinically localized prostate cancer.

RESULTS
OC, ECE, SVI and LNI were noted in 63.5%, 23.1%, 10.5% and 2.9% of cases, respectively. AUC of the 2001 tables was 0.787, 0.766, 0.775 and 0.790, for OC, ECE, SVI and LNI, respectively. These values were virtually the same as the respective 1997 Partin table AUC values, namely 0.784, 0.728, 0.791 and 0.799.

CONCLUSIONS
This external validation of the 2001 Partin tables confirms good predictive accuracy of the updated tables. However, predictive accuracy in this external validation data set of 2,139 European men is virtually the same as that of the original 1997 tables. Therefore, a transition from the 1997 tables to the updated 2001 version does not appear warranted unless superior accuracy is demonstrated in other external cohorts.


In the above paper, Weiss and Jen present an analysis of a modified feedback current switch which is fundamentally in error. In addition, they claim several advantages due to the modification which in fact do not exist.


PURPOSE: A bio sensor and a method for measuring density of glucose by using the same are provided to precisely measure density of glucose by using mesoporous platinum as an electrode. CONSTITUTION: A bio sensor includes an electrode and a mesoporous platinum layer formed on the electrode. The electrode is made from an inert metal. The mesoporous platinum layer has plural pores aligned in a hexagonal alignment pattern with a size of about 1.5 to 3nm. The mesoporous platinum layer is coated on the electrode with a thickness of about 60 to 600nm. Voltage is applied to the bio sensor. Then, current intensity applied to the bio sensor is analyzed. The voltage applied to the bio sensor is in a range about -0.1 to 0.5V.


Pioneer in antibiotics and industrial microbiology The quietly brilliant industrial microbiologist H. Boyd Woodruff, whose work underpinned two Nobel Prizes, died at home in Watchung, NJ, on 19 January. He was 99. We lost a dear friend and mentor, and the world lost one of its last living links to the dawn of antibiotic discovery. Boyd played a major role in the expansion of the pharmaceutical industry from relying primarily on chemistry to also embracing microbial natural products.


Simple Summary Breast cancer is a complex pathology characterized by several features including molecular subtype (MS). Immunohistochemistry assays were used to investigate the expression of enzymes involved in glycolysis and gluconeogenesis. The analysis involved stratifying the data based on MS, body mass index (BMI), and the combination of BMI with MS (mBMI). This study revealed significant differences in the expression of three specific enzymes—pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PCK), and fructose-1,6-bisphosphatase (FBP)—among tumor cells when stratified by MS and mBMI. Moreover, the expression levels of these enzymes were found to be closely related to hormonal receptor and HER2 status, as well as correlated pathological stage and histological grade. Obesity appeared to have an impact on these differences, particularly in the expression of PC. However, it was observed that these differences were not influenced by the presence of adipocyte deposition or inflammatory infiltration within the tumor microenvironment. Nevertheless, the expression of PCK and FBP was also influenced by the presence of obesity-related conditions such as diabetes, hypertension, and dyslipidemia. In summary, this study highlights the existence of distinct metabolic profiles for breast cancer based on its molecular subtypes, and how these profiles are affected by obesity and related health conditions. Abstract Breast cancer is a heterogeneous entity, where different molecular subtypes (MS) exhibit distinct prognostic and therapeutic responses. A series of 62 breast cancer samples stratified by MS was obtained from the tumor biobank of IPO-Porto. The expression of glycolysis and gluconeogenesis-regulating enzymes was investigated by immunohistochemistry. Data analysis included stratification according to MS, body mass index (BMI), and BMI with MS (mBMI). We observed significant differences in pyruvate carboxylase (PC), phosphoenolpyruvate carboxykinase (PCK), and fructose-1,6-bisphosphatase (FBP) tumor cell expression when stratified by MS and mBMI. The expression of these enzymes was also statistically dependent on hormonal receptors and HER2 status and correlated with pathological stage and histological grade. Obesity tended to attenuate these differences, particularly in PC expression, although these were not affected by adipocyte deposition or inflammatory infiltration at the tumor microenvironment. Nonetheless, PCK and FBP expression was also modified by the presence of obesity-associated disorders like diabetes, hypertension, and dyslipidemia. Taken together, these findings identify metabolic fingerprints for breast cancer as distinct histological types, which are affected by the presence of obesity and obesity-associated conditions. Despite the biological role of the differential expression of enzymes remaining unknown, the current study highlights the need to identify the expression of gluconeogenic-regulating enzymes as a tool for personalized medicine.


The present study was performed at three diverse agro-climatic zones of Indian Punjab. A validated DSSAT-CANEGRO model was used to simulate the response of different climate change scenarios on cane yield of four sugarcane varieties (CoPb 91, CoJ 88, Co 118 and Co 238) for each zone. Results described that elevated and lowered minimum temperature upto 3.0°C may alter cane yield by -17.9 to 18.0 per cent. Similarly, ±3.0°C altered maximum temperature may change the cane yield by -17.6 to 17.5 per cent. The sugarcane yield may be decreased by 2.4 to 14.4 per cent, 3.3 to 17.6% and 0.3 to15.4 per cent with 2.5 to 15 per cent reduced solar radiation and increase in the same unit may enhance the yield by 1.9 to 9.0 per cent, 1.3 to 13.6 per cent and 2.0 to 12.3 per cent at Faridkot, Gurdaspur and Kapurthala, respectively. A±30 mm rainfall may change the cane yield by 9.2 to 18.0 % similarly, rise and fall in CO2 by 5 to 30 ppm was able to increase and decrease the cane yield by 2.4- 22.6 and 3.5 - 27.8 per cent, at different regions. This study confirmed that for sugarcane cultivation in Punjab CoPb 91 should be preferred. However, CoJ 88 and Co 238 may suffer cane yield loss of 7.8 and 9.9 per cent respectively.


128 www.ccmjournal.org January 2020 • Volume 48 • Number 1 The development of new-onset atrial fibrillation (AF) is a common complication that alters the course of critical illness. New-onset AF occurs in at least 8% of patients in the ICU and is associated with adverse outcomes (1–4). Patients with new-onset AF demonstrate higher vasopressor and inotrope requirements, higher net positive fluid balance, and a higher rate of diastolic dysfunction (5), and had longer lengths of stay in the ICU and hospital (4). In the long term, new-onset AF during critical illness has been associated with an increased risk of heart failure, ischemic stroke, and death (1, 6). Since newonset AF represents a significant complication of critical illness, it is imperative to characterize and understand the risk factors for the disease. Identifying patients at risk for new-onset AF might allow interventions targeting AF prevention, a goal which has been proposed (7). Although predictive models based on known risk factors for new-onset AF exist (8), such models have imperfect performance and do not account for the strong genetic predisposition reported in studies of ambulatory patients (7). Parental AF increases the future odds for an individual's AF by 1.8 to three-fold (7). New-onset AF likely represents a complex gene-environment interaction in which an underlying susceptible substrate and the profound physiologic derangements of critical illness interact to produce the arrhythmia. In order to evaluate a gene-by-environment interaction, environmental risk factors must be understood. Studies using data from prospective cohorts (5, 6), claims data (2), and retrospective cohorts (4) have identified risks for new-onset AF specific to the critical illness context: acute organ failures, immunocompromise, presence of sepsis, and use of inotropic medications. In addition, factors common to ambulatory AF have been identified, such as age, sex, obesity, Caucasian race, and cardiac disease (2, 4–6), although studies restricted to critically ill populations do not uniformly identify traditional risk factors of diabetes mellitus, hypertension, or congestive heart failure during the ICU setting (2, 5). Although genetic factors conferring risk of new-onset AF in the ambulatory patient population are replicated and well characterized, the genetics of new-onset AF during critical illness is relatively unexplored. The physiologic stresses encountered during critical illness, including systemic inflammation and increased adrenergic activity, may be unique compared with new-onset AF developed in the ambulatory setting. Human experimental studies with endotoxin prove the existence of differential genetic regulation between quiescent states and stress-evoked inflammation (8). Uncovering the genetic risk factors for new-onset AF during critical illness might advance our understanding of the disease and the targeting of at-risk patients in a precision medicine paradigm. In a this issue of Critical Care Medicine, Kerchberger et al (9) assess the significance of genetic variation as a risk factor for new-onset AF during critical illness. In a candidate gene approach, the authors tested well-validated AF-associated single-nucleotide polymorphisms (SNPs) from prior genomewide association studies in ambulatory populations. To identify new-onset AF in critically ill patients, they leveraged a substudy from the Validating Acute Lung Injury markers for Diagnosis (VALID) cohort, a prospective observational cohort study of critically ill adults admitted to medical or surgical ICUs in whom AF was determined by manual screening of the medical record (5). Genotyping was performed using a customized multi-SNP platform (9). The authors identified three SNPs—rs3853445, rs6838973, and rs12415501—previously identified as genome-wide ambulatory AF variants as also being associated with new-onset AF during critical illness. The associations between AF and two SNPs (rs3853445 and rs12415501) were robust to adjustment for statistically significant clinical variables. The authors also report that both rs3853445 and rs12415501 may have biological significance in new-onset AF. Rs3853445 is within a noncoding intergenic region near PITX2, paired like homeodomain 2. A homeobox transcription factor, PITX2 has been implicated in cardiac electrical and structural remodeling (10). The gene within which rs12415501 resides, NEURL (neuralized E3 ubiquitin protein ligase 1), has been linked to atrial action potential duration (11). To study the effect of genetic variation in concert with environmental stresses, Kerchberger et al (9) used clinical predictors for new-onset AF previously identified in the VALID population (5) and then applied a least absolute shrinkage and selection operator (LASSO) regression model to select the most informative AF predictors while avoiding selection of co-linear variables. The LASSO model retained age, sex, history of previously diagnosed coronary artery disease, and use of vasopressor as the leading clinical variables associated with new-onset AF. Both rs3853445 and rs12415501 were also retained by the LASSO regression as AF predictors. Finally, the authors tested a combined clinical and genetic risk model 0090-3493


Based on a study of the Broyden–Fletcher–Goldfarb–Shanno (BFGS) update Hessian formula to locate minima on a hypersurface potential energy, we present an updated Hessian formula to locate and optimize saddle points of any order that in some sense preserves the initial structure of the BFGS update formula. The performance and efficiency of this new formula is compared with the previous updated Hessian formulae such as the Powell and MSP ones. We conclude that the proposed update is quite competitive but no more efficient than the normal updates normally used in any optimization of saddle points. © 1998 John Wiley & Sons, Inc. J Comput Chem 19: 349–362, 1998


This discussion will address clinical, procedural, and theoretical issues raised by Lyons and Williams in response to my paper. I will elaborate on potential enactments, the erotic transference, and the third as related to the case.


Outsourcing, contracting-out and the use of labour hire all have potentially dramatic consequences for HRM and human resource development in partic ular. Advocates of outsourcing have traditionally...


In designed experiments and surveys, known laws or design feat ures provide checks on the most relevant aspects of a model and identify the target parameters. In contrast, in most observational studies in the health and social sciences, the primary study data do not identify and may not even bound target parameters. Discrepancies between target and analogous identified parameters (biases) are then of paramount concern, which forces a major shift in modeling strategies. Conventional approaches are based on conditional testing of equality constraints, which correspond to implausible point-mass priors. When these constraints are not identified by available data, however, no such testing is possible. In response, implausible constraints can be relaxed into penalty functions derived from plausible prior distributions. The resulting models can be fit within familiar full or partial likelihood frameworks. The absence of identification renders all analyses part of a sensitivity analysis. In this view, results from single models are merely examples of what might be plausibly inferred. Nonetheless, just one plausible inference may suffice to demonstrate inherent limitations of the data. Points are illustrated with misclassified data from a study of sudden infant death syndrome. Extensions to confounding, selection bias and more complex data structures are outlined.


Objective To determine the normal principle of treatment plans,appropriate methods of space closure and clinical effects in orthodontic treatment cases with first molar extractions.Methods Forty-two cases with first molar extractions in the past five year were included.The cases with normal premolar extractions served as control group.All cases were treated with MBT.The treatment time and clinical effects were compared.Results The average treatment time of first molar extractions was(22±5.6) months,the control group was(20±8.9) months.There was no significant difference between two groups.All the cases were finished with paralleling root,satisfying molar relationship,normal overbite and overjet.Conclusion With the development of orthodontic technique,the same clinical effects can beachieved in the cases with first molar extractions and premolar extractions.


SZK 339 Xinhua strobe microcomputer automatic control system is an automatic product specialy used for water strobe control, and it is a computer supervisory control system designed for the need of operation management for xin hua stobe. The statistic for water usage adopts advanced ultrasonic flowmeter and wireless transmission system. Through the real-time supervisory control by the host computer, PLC is in the charge of specific control for the strobe position and liquid position. For the implement of the system, the real-time dynamic supervisory picture is designed, and the manual or automatic operational mode can be selected according to the requirement. It highly improves the automatic management level of xin hua stobe.


After globalization; living in the most profound effects of the accountancy profession dimensions of internationalization; already in an office, is considered as an occupation area of the execution of local operations. However; ACCA, XBRL, concepts such as IFRS or strategic partnerships, demonstrate the need to be addressed in the international integration process of this profession. Today, local thinking, just considering the fact that reveal the results beyond the local competence; think of the international dimension of such a formation or to be accredited, the reconsideration of the existing accountancy organizational structure and will need to run the restructuring process in this direction.