Moringa oleifera is a plant that has copious medicative properties and widely known as "drumstick plant" or "horseradish plant" and most widely vascular plant in India. This is a nutritional plant (herb) that consists of many pharmacological and biological exertion such as antiasthmatic, diuretic, antiepileptic, cardiovascular as well as antioxidants and also beneficial in wound healing enterprise. The anti-asthmatic action of M. oleifera seeds kernel ethanolic extract evoked by histamine and acetylcholine aerosol. Pre-treatment by ethanol gives the extract of M. oleifera also diminished carrageenan convinced rat paw edema that was comparable to standard diclofenac sodium. This review summarizes the biological exertion such as a cardiovascular, diuretic, and biological activities such as antimicrobial, antiepileptic, and anti-allergic activities and also provides pharmacological activities in essence anti-cancer, anti-diabetic, and anti-asthmatic activities.


The concept of Deep Time is one of modern science's most important conquests. The extension of planet Earth's geological scale, along with the scientific research about biological evolution, modified the previous religious and philosophical worldview in an irreversible and counterintuitive way. Since then, the inclusion of this conceptual revolution into a cosmological scale has given an even more mind-blowing depth to time. Interestingly, even though they lacked a proper explanation for evolution's mechanisms (which would become later effective only with the adoption of the Darwinian research programme), ancient myths and folktales tried somehow to make sense of the fossil records by providing pre-scientific explications and sometimes even a diachronic background within a fictitious cosmological setting. Since then, and from the standpoint of the historiography of natural history, the transition from a theological model to a scientific paradigm was all but painless, and a harsh struggle dominated by the confused ideological reference to teleological and moral coordinates still persists today. The purpose of this paper is twofold. Firstly, it provides a thorough walk-through about geomythology, which is the discipline devoted to the study of religious and folkloric records concerning explanations of geological phenomena and fossils. Secondly, it supplies a historiographical discussion of the complicated confrontation between the scientific enfranchisement of rational inquiry from theological constraints and the accommodationist dependence on religious beliefs which distinguished the modern study of natural history. Lastly, the conclusion of the paper highlights a critical review of contemporary unscientific and creationist misunderstandings, gross mistakes and preconceptions, widespread in the field of religious studies, and in the academic milieu as well.


<abstract>
In this paper, dedicated to Ireneo Peral, we study the regularizing effect of some lower order terms in Dirichlet problems despite the presence of Hardy potentials in the right hand side.
</abstract>


A new remote sensing retina vision system aimed at classifying rapid moving objects, such as Space debris, based on their motion patterns, is presented. The purpose of this study is to investigate how different types of target complex motion patterns can be detected and discriminated with high accuracy. The remote retina vision sensing system consists of an asynchronous event-based neuromorphic camera coupled with polarization filters enabling improved detection, tracking, and discrimination, with high contrast and dynamic range; a spinning light modulating wheel, operating at varying angular frequency, is placed in front of a static target. The outcome of this study indicates that deep learning combined with Polarimetric Dynamic Vision Sensor p(DVS) principles is well suited to accurately classify targets based on distinct salient features, such as motion patterns, rapidly, at low operational bandwidth, low-power consumption, and storage.


ABSTRACT For a one-sided truncated exponential family of distributions with a natural parameter θ and a truncation parameter γ as a nuisance parameter, it is shown by Akahira (2013) that the second-order asymptotic loss of a bias-adjusted maximum likelihood estimator (MLE) of θ for unknown γ relative to the MLE of θ for known γ is given and and the maximum conditional likelihood estimator (MCLE) are second-order asymptotically equivalent. In this paper, in a similar way to Akahira (2013), for a two-sided truncated exponential family of distributions with a natural parameter θ and two truncation parameters γ and ν as nuisance ones, the stochastic expansions of the MLE of θ for known γ and ν and the MLE and the MCLE of θ for unknown γ and ν are derived, their second-order asymptotic means and variances are given, a bias-adjusted MLE and are shown to be second-order asymptotically equivalent, and the second-order asymptotic losses of and relative to are also obtained. Further, some examples including an upper-truncated Pareto case are given.


Advertising is one of the most effective and efficient tools since it combines audio and visual to display, describe, and demonstrate the advertised product in a short time. Gudang Garam television advertisements in 80s, 90s, 2000s are chosen to be analyzed since the three of which are considered to be the representatives of Gudang Garam cigarette advertisements in each decade. The aim of this research is to find out the signification concepts represented in Gudang Garam advertisements. Considering the nature of the source data, this research uses qualitative as method. The research employed semiotic approach and Stuart Hall's Representation as tools of analysis. The results are the significations concept that is used in the the first advertisement aired in the 80s is the universality of Gudang Garam cigarette consumers. Meanwhile, in the second advertisement, the signification concept found is the masculinity of Gudang Garam consumers. However, the signification concept found in the third advertisement is the modernization image of Gudang Garam as a cigarette manufacturer.


Background: Hepatocellular carcinoma (HCC) is a common malignant tumor with high mortality and mortality. Although advances in early diagnosis, disease management and treatment of HCC, the outcomes remain unsatisfactory. This study aimed to identify the reliable prognostic biomarkers based integrated bioinformatics analysis to predict and improve the survival of HCC patients. Methods: The gene expression or transcriptome profiles and survival of HCC were acquired from the Gene Expression Omnibus database (GEO) and the Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) were screened out by the limma or edgeR package in the R software. Univariate, LASSO and multivariate Cox regression analyses were conducted to explore survival-related signature. Subsequently, a prognostic model and nomogram composed of prognostic signature were constructed for assessing overall survival (OS). Kaplan-Meier analysis, receiver operating characteristic (ROC) curve and stratified analysis were performed to confirm the prognostic performance of the prognostic model.Results: Compared with nontumor samples, 451 reliable DEGs were identified using the robust rank aggregation and overlap validation. Eleven survival-related DEGs were selected for the construction of a risk evaluation model, which could efficiently distinguish high-risk patients from low-risk patients and even be feasible in the subgroups of stages and age. Further analyses suggested the positive and independent prognostic performance of the model compared to other clinical characteristics (P< 0.05, ROC > 0.7). Finally, a prognostic nomogram composed of the model was constructed for assessing the overall survival, and Harrell's concordance index and calibration curves demonstrated its efficient predictive performance. Conclusion: The predictive model and nomogram will contribute directly to further clinical applications in the individualized survival prediction, the improvement of treatment strategies and more accurate management for patients with HCC.


Characterizing the dynamics of energy flow through ecosystems requires quantifying the degree to which primary and secondary production are coupled. This coupling is expected to be tight in ecosystems with high internal production relative to external carbon and energy inputs. We experimentally quantified the dependence of aquatic insect emergence on fresh primary production, specifically for the midge population in Lake Mývatn, Iceland. Using field mesocosms, we manipulated algal primary production by reducing light availability via shading. We then used dissolved oxygen incubations to estimate fluxes of carbon through photosynthesis (i.e., gross primary production or "GPP") over the course of the experiment. We found that elevated GPP was associated with higher emergence rates of adults, as judged both by comparison of emergence across the experimental shading treatments and estimates of in situ GPP within the mesocosms. Furthermore, larger adults emerged earlier than smaller ones, suggesting that asymmetries in resource availability among individuals affected the timing of emergence. Nonetheless, midge emergence was substantial under light-limiting conditions, indicating that while midges benefit from primary production contemporaneous with larval development, they are also capable of completing their life cycles on carbon already existing in the organic matter pool. Our results show that even in systems with limited allochthonous inputs, contemporaneous primary production may be not necessary for high secondary production and insect emergence. Instead, consumers can develop from consumption of biomass derived from past autochthonous primary production. This suggests that primary production and consumer dynamics can be partially decoupled in time in systems that depend on internal production.


Modification of T cells with chimeric antigen receptors (CAR) has emerged as a promising treatment modality for human malignancies. Integration of co-stimulatory domains into CARs can augment the activation and function of genetically targeted T cells against tumors. However, the potential for insertional mutagenesis and toxicities due to the infused cells have made development of safe methods for removing transferred cells an important consideration. We have genetically modified human T cells with a lentiviral vector to express a CD20-CAR containing both CD28 and CD137 co-stimulatory domains, a "suicide gene" relying on inducible activation of caspase 9 (iC9), and a truncated CD19 selectable marker. Rapid expansion (2000 fold) of the transduced T cells was achieved in 28 days after stimulation with artificial antigen presenting cells. Transduced T cells exhibited effective CD20-specific cytotoxic activity in vitro and in a mouse xenograft tumor model. Activation of the iC9 suicide switch resulted in efficient removal of transduced T cells both in vitro and in vivo. Our work demonstrates the feasibility and promise of this approach for treating CD20+ malignancies in a safe and more efficient manner. A phase I clinical trial using this approach in patients with relapsed indolent B-NHL is planned.


ABSTRACT Collaborative efforts of the Hawai'i State Center for Nursing (HSCN) and participating local hospitals, supported by local medical libraries, provide training in evidence-based practice (EBP). A critical part of the program was integrating the concepts of The Iowa Model of EBP developed by Dr. Marita G. Titler. The Iowa Model includes critique and synthesis of the best literature, identifying stakeholders and identifying triggers in the process of moving evidence into practice (1). The resulting training program led to the development and implementation of numerous nurse-driven projects and 14 peer-reviewed publications that have demonstrated a positive impact on clinical operations within Hawai'i state health organizations including Hawai'i Pacific Health (HPH). This article focuses on collaboration between the HPH EBP program, the HPH Library and the practical application and impact of that concept in a clinical setting.


Power is first an ontological concept basic to understanding a reality of potentialities and actualities. Our world is a flux of possibilities becoming actual, dispositions becoming manifest, determinables becoming specific. Reality is not only being, but becoming. It is active, a field of potentialities and tendencies struggling against each other to become actual, completed, determinate What is power within this view? First, power is the linkage between different states of being; between potentialities and actualities, between dispositions and manifestations, and between determinables and determinants (specifics). Second, that linkage is a strength-of-becoming, an active will-to-completeness. It is a push from the level of pure potentiality, of mere possibility, to ever greater levels of clarity and definiteness. Third, it is an imminent energy, an inherent force-towardsidentity of all beings Finally, in essence, power is a vector-towards-manifestation (p. 165).


Barriers to adult immigrants' access of health services have been
 identified: communication problems; health services' burocracies; health-care providers'
 biases; low SES (e.g. Dias et al., 2009; Straub, 2012). Nevertheless, few studies have focused
 on immigrant children (Mendoza, 2009). This study developed a Grounded Theory (GT) on the
 determinants of immigrants' access to Child Health Surveillance Services (CHSS) in Portugal. 5
 focus groups and 10 individual interviews were conducted, including: 17 Cape Verdean, 12
 Brazilian and 7 Portuguese caregivers, from heterogeneous SES; allowing the identification of
 common and specific determinants of immigrant and Portuguese caregivers' access to CHSS. Data
 was analyzed using a GT methodology (Strauss & Corbin, 1990). (Not)Go to CHSS is the
 theory's nuclear concept. Its common main determinants were: perceptions of CHSS
 usefulness; consultation scheduling; vaccination as the perceived main activity of CHSS.
 Immigrants specific determinants of CHSS access were: degree of access to primary health care,
 related to (not)having social support and to immigrants' legal status in Portugal;
 (cultural)differences in health surveillance conceptions. These findings may contribute to
 improve immigrants' access to CHSS.


We present a general method to control the phase space structure of charged particle beams by both Hamiltonian and non-Hamiltonian manipulations by employing multiple optical pulses. In particular, we focus on beam cooling as an example of the method. In order to rapidly cool a bunched beam of charged particles, one needs to introduce non-Hamiltonian manipulation of the internal structure of the phase space of the bunch. A spatially dependent force, which cancels the velocity moment fluctuations arising from the irregularity and granularity of the phase space, is shown to be effective in cooling the bunch. We introduce a method of cooling by creating a ponderomotive force due to a beat between a laser and an undulator that are appropriately adjusted turn by turn through feedback. If a high enough resolution feedback system can be achieved, this results in a rapid reduction of the longitudinal emittance of the bunch with a corresponding increase in the phase space of the scattered laser light. In this process we find that when the structure of the laser input is matched well with that of the beam, a large amount of entropy transfer without much energy transfer takes place ({open_quotes}entropy resonance{close_quotes}), while when itmore » is ill matched, no such entropy resonance takes place. We measure the correlation dimension and higher entropy of the scattered laser light. It is found that both quantities are useful for determining the amount of cooling. By combining an appropriately timed Hamiltonian longitudinal beam stretching with the present cooling procedure, we can continue the cooling. Numerical simulation is carried out to demonstrate this method. {copyright} {ital 1997} {ital The American Physical Society}« less


The quadrupole moments were determined by means of Coulomb excitation experiments. Highly enriched targets were bombarded with 53 MeV /sup 16/O ions. Elastically and inelastically scattered ions were detected in a split pole spectrograph. The results are in good agreement with muonic x-ray data.


A single-stage aerobic biological treatment system was developed specifically to convert organically bound chlorine to inorganic chloride. In initial laboratory tests, greater than 90% reduction of AOX was achieved in synthetic dichlorophenol, commercial pentachlorophenol, and combined kraft wastewaters, and less than a week was required for startup/acclimation. A six-month field test of the process on a pentachlorophenol wastewater was very successful under highly variable influent conditions. No chlorinated byproducts were detected, and measurements strongly indicated that dehalogenation had occurred. Recent experiments found Cl/El wastewater to be most easily treatable by the aerobic process, followed by combined lagoon influent, El wastewater, and finally lagoon effluent. However, results have indicated that application of the treatment process to kraft AOX reduction can become feasible only if further process improvements can be defined.


During the past three years, transport characteristics of coal-water mixtures (CWMs) have been studied at the Pittsburgh Energy Technology Center. The effort has concentrated predominantly on studying flow conditions in straight horizontal and vertical sections, and to a lesser extent on studying the flow patterns around elbows of a one-inch-diameter loop and a two-inch-diameter loop. Steady-state flow was characterized for in-house prepared slurries and commercially prepared slurries. For lower concentrated slurries (55 wt % to 60 wt %) and coarse particle size distributions (50% finer than 75 microns), nonhomogeneous flow conditions were encountered across horizontal test sections. Since nonhomogeneous conditions existed in straight sections during steady-state flow, it was decided to further investigate flow conditions during changes in velocity (magnitude and direction). This paper concentrates on nonuniform flow conditions of two types. The first nonuniform flow condition arises from sudden increases in the magnitude of the flow velocity. Pressure measurements recorded at a fixed position in the vertical section of the two-inch-diameter loop during sudden changes in velocity can be analyzed via classic control theory to evaluate the dynamic properties of the CWM. The second nonuniform flow condition occurs as the CWM passes through a bend. Both long-radius bends andmore » 90-degree elbows made of glass and steel have been studied. Pressure-loss data around the long-radius bends and elbows were analyzed with a modified version of the model developed by Ito for single-phase flow around bends. Flow patterns around glass bends and elbows were observed for slurries prepared of vinyl coating powder and water. They are described in an effort to increase understanding of the pressure-loss data. 8 refs., 11 figs., 1 tab.« less


The hotwire method was used to determine the thermal conductivity of grain.At room temperature,the thermal conductivity of paddy increased along with the increase of moisture content and temperature.The thermal conductivity of Indica rice Zhong You 218 varied from 0.0998 W/m·℃ to 0.1223 W/m·℃ with the moisture content changing from 6.57% to 20.08%.And that of Guangdong early season indica rice varied between 0.0826~0.1166 W/m·℃ with its temperature changing from 6.51 to 35.03℃.Different paddy variety has different thermal conductivity.Thermal conductivity of indica rice is higher than that of japonica rice.


In Latin American countries there is a high waste of fresh fruits. The producers process them, for elaboration of juices and concentrates, industry that generates a large amount of waste. The purpose of the research was to use the waste generated by the industry in the elaboration of a comfiture of shell and albedo of grapefruit. A Random Blocks Design with a factorial arrangement of 2×2 was used, two flavorings (passion fruit juice and grapefruit juice) and two sugars (panela and invert sugar/panela) and one control (sugar and passion fruit juice); It was evaluate pH, microbiological analysis of fungi, yeasts and enterobacterias; An acceptance sensory analysis for the attributes of color, odor, gumminess, sweetness, acidity and general acceptance was also performed. The most accepted treatments were submitted to an analysis of Aw, texture (gumminess), sugar profile, and variable formulation costs were determined. A Completely Random Design was used with two treatments. The factor sugar had a higher influence in the physicochemical analysis, the treatments of inverted sugar/panela-passion fruit and sugarpassion fruit were the most accepted, the use of inverted sugar/panela increases the Aw (0.66), reduces gumminess (51.54 mJ) and total sugars with respect to the sugar. The use of panela in the treatments raised the variable costs of formulation with respect to the sugar. For future tests, it is recommended the use of other sweeteners to reduce the sugar content of the comfiture.


Progestin‐facilitated lordosis of rodents is enhanced by activation of dopamine type 1 (D1) or GABAA receptors, their downstream G‐proteins, and/or second messengers in the ventral tegmental area (VTA). We examined whether the ability of progestins to enhance lordosis via actions at D1 and/or GABAA receptors is contingent upon activation of the second messenger phospholipase C (PLC) and its associated kinase, protein kinase C (PKC), in the VTA. If the actions of progestins through D1 and GABAA receptors in the VTA are mediated through PLC and PKC, then inhibiting PLC formation (Experiment 1) or blocking PKC (Experiment 2) should reduce progestin‐facilitated lordosis and its enhancement by D1 (SKF38393) or GABAA (muscimol) receptor agonists. In Experiment 1, ovariectomised hamsters, primed with oestradiol (10 µg; h 0) + progesterone (100 µg; h 45), were pretested for lordosis and motor behaviour (h 48) and then infused with the PLC inhibitor, U73122 (400 nM/side), or vehicle. Thirty minutes later, hamsters were retested and then received infusions of SKF38393 (100 ng/side), muscimol (100 ng/side), or vehicle to the VTA. Hamsters were post‐tested for lordosis and motor behaviour 30 min later. In Experiment 2, a similar protocol was utilised except that instead of the PLC inhibitor hamsters were infused with the PKC inhibitor, bisindolylmaleimide (75 nM/side). Systemic progesterone, SKF38393‐, and muscimol‐facilitated lordosis was attenuated by infusion of the PLC inhibitor, U73122, or the PKC inhibitor, bisindolylmaleimide, compared to vehicle to the VTA. Thus, the actions of progestins in the VTA to enhance lordosis through D1 and/or GABAA may include downstream activity of PLC and PKC.


The interaction of deuterium gas (D2) with nominally dry SiO2 on Si was characterized in the temperature range 100–1000 °C using high‐sensitivity nuclear‐reaction analysis for D. Two trapped configurations were distinguished: one, hypothesized to involve Si–D bonding, produced D uptake at 300 °C and above followed by release at 600 °C; the other, identified as O–H, formed readily at 100 °C and dissociated at about 800 °C. Retained D in the 0.5‐μm oxide layer was present at areal densities of about 1014 atoms/cm2 or less, and it was distributed approximately uniformly except for a small surface peak. Prior irradiation with high‐energy He ions increased the D uptake by two orders of magnitude through, it is believed, the same trapping mechanisms discussed above. The data on uptake and release were semiquantitatively described by a fitted mathematical model, from which effective activation energies for trapping and detrapping were obtained.


Hyperparathyroidism is characterized by high levels of circulating calcium due to an increased secretion of parathyroid hormone (PTH) by one or more of the parathyroid glands. It is estimated that 28 out of every 100,000 people in the U.S. will develop this disorder. A standard treatment for hyperparathyroidism is surgical removal of the affected gland(s). However, pharmacological intervention with vitamin D analogs of calcimimetics is an option for those patients with mild cases or secondary hyperparathyroidism. The extracellular calcium sensing receptor (CaR), a low affinity G-protein-coupled receptor, is found in high levels on the surface of parathyroid cells, where in response to small changes in extracellular calcium, they regulate secretion of PTH. The CaR is an attractive therapeutic target for the design of novel calcimimetics for the treatment of hyperparathyroidism because alterations in CaR expression are thought to be responsible for inherited forms of hypercaicemia and hyperparathyroidism, and acquired alterations in this receptor could be responsible for the pathogenesis of primary hyperparathyroidism and secondary hyperparathyroidism due to renal failure. Cinacalcet hydrochloride is a novel second-generation calcimimetic that modulates the CaR by making it more sensitive to the calcium suppressive effects on PTH secretion. It has a high oral bioavailability and has been chosen for further development as a treatment for primary and secondary hyperparathyroidism.


Investors can exploit the correlations between international stock markets by trading no-load, open-end, international mutual funds. These investors in effect cheat passive investors because they buy the mutual funds at their net asset values, which do not reflect information released during the US trading day. The strategy we examine yields an annual rate of return 800 basis points above the S&P500, over a period of almost eight years. Copyright Blackwell Publishers Ltd 1998.


Synopsis The types of modes which may exist in an infinite parallel-plate waveguide with a centrally-placed unidirectionally conducting screen are studied. The effect of bifurcating an infinite parallel-plate waveguide by such a screen in the region x>O is investigated when a transverse electric mode is incident on the bifurcated region. The problem is solved by the Wiener-Hopf method, and expressions are derived for the amplitudes and phases of the reflected and transmitted modes. It is found that the transmitted field contains a hybrid wave and a slow wave, and the reflected field contains transverse electric and transverse magnetic waves.


In semiconductors, electrons and their corresponding holes exist as free carriers that are created in pairs in inter-band transitions. At very high carrier densities, the carrier-carrier collisions dominate over carrier-lattice collisions and these carriers begin to behave collectively to form a plasma. In this study, we present phase-matched terahertz (THz) radiation generation from laser interaction with electron-hole plasmas. Two collinear laser pulses of finite spot size propagate in an electron-hole plasma to generate THz radiation. The lasers beat and exert a ponderomotive force on electrons and holes. The carriers oscillate with oscillatory velocity at the laser beat frequency. The laser beat wave interacts with the plasma density perturbation and produces a nonlinear transverse current with nonzero curl. This nonlinear current drives coherent THz radiation. Spacial density modulation of hole density is considered to satisfy the phase-matching condition for resonant interaction. The systematic analysis of this mechanism shows an efficient and tunable source of THz radiation, which varies with various parameters such as the density modulation, laser intensity and other laser parameters.


Multi-layered thin films of TiO2 and TiN were created by rf reactive magnetron sputtering, and their crystalline, optical, and photoelectrochemical properties were measured. The overall composition of the films (TiO2-to-TiN ratio) was kept constant with the height of each film. The number of layers and thickness of each layer was controlled to create bi-layer thin films that were composed of: 9 bi-layers, 18 bi-layers, 27 bi-layers, 36 bi-layers, and 45 bi-layers. XRD patterns were observed for each film after annealing to measure the grain size and composition of anatase and rutile as a function of temperature. It was found that the phase-transition temperature is able to be substantially controlled (between 550 °C and 850 °C) for the anatase to rutile transition by varying the number of layers/thickness of each layer. In addition, bi-layer stacking significantly affected the film's optical properties by lowering the bandgap into the visible-light region, and also showed up to three times the improvement...


Students majoring in computer science at the United States Military Academy (USMA) must take a course in operating systems. In this course the students complete a series of laboratory projects to learn the basic concepts of modern computer operating systems. During the last three semesters, our operating system laboratory scheme evolved (1) from having the students master a series of separate, unconnected projects (2) to modifying an existing operating system simulation (3) to finally having them completely build an operating system. This article will discuss each approach, its strengths and weaknesses and the rationale for changing to our current program.


Bridge performance undergoes time-varying changes when exposed to aggressive environments. While much work has been done on bridge reliability under corrosion, little is known about the effects of creep and shrinkage on the reliability of concrete bridges. In this paper, the CEB-FIP model for creep and shrinkage is applied by using finite-element (FE) analysis in conjunction with probabilistic considerations. Verification is made by comparing the analytical findings with existing test data. More specifically, a time-dependent reliability assessment is made for a composite prestressed concrete (PSC) box-girder bridge exposed to a chloride environment. This realized via an advanced probabilistic FE method. The postcracking behavior of the thin-walled box girder is described using composite degenerated shell elements, and importance sampling is used to improve the efficiency of the reliability analyses. It is shown that concrete creep and shrinkage dominate during the early stages of bridge structure deterio...


Introduction/Aim: A Dupuytren's contracture is traditionally measured using a goniometer. Previous work has shown the equivalence of goiniometer and app-based measurements when performed by a clinician. This study aims to assess whether a patient's assessment of their Dupuytren's contracture correlates with a clinician's assessment through the use of app-based technology and digital photography. Methods: Informed consent was obtained to photograph 20 clinic patients with Dupuytren's contracture. Only joint deformities of the little finger were measured. The deformity was photographed and measured initially by the patient using ''my measures pro'' application on a mobile device and subsequently by the treating clinician. Results: The deformities of 20 consecutive patients were photographed and measured. This provided 21 paired measurements; eight MCPJ, 12 PIPJ, and one DIPJ. There was no significant statistical difference between clinician and patient measured angles (p1⁄4 0.67, 95% CI 2.64to 1.74degrees). Conclusion: Digital app based photography is a reliable tool for patients to independently assess and monitor their deformity in Dupuytren's disease. Wider integration in clinical practice could allow remote monitoring of patients below the threshold for surgery reducing clinic appointments. Additionally, it could provide a low-cost tool for assessment and comparison of contracture recurrence over time for different treatments. Intermetacarpal Fusion for the Treatment of Failed Trapeziectomies – A Midterm Follow up of this Salvage Technique


We developed a deterministic model to opti- mize DNA fingerprinting effort in the presence of gene flow during the application of Breeding without Breed- ing. The method considers trait's heritability, level of gene flow, selection differential, and the proportion of progeny test subjected to fingerprinting (truncation). All the model's variables individually or in concert proved important; however, the trait's heritability mag- nitude played the most important role in minimizing the selection of contaminated individuals and it could be used as a surrogate to traits with low heritability.


With the rapid development of rail transit in China, there is a great demand for the manufacturing capacity of intelligent equipment. Facing the demand of efficient cleaning of work-piece in rail transit, this paper proposes the automatic cleaning of assembly work-piece of railway vehicle by intelligent robot.Intelligent industrial robots are used to wash and deburr the work-piece in the intelligent processing. The main cleaning parts are fasteners, rods and valve bodies. The main technology is clean and deburr the work-piece with holes and deep holes. Binocular vision is used to identify the coarse positioning and fine positioning of the work-piece with holes, and different types of work-pieces are stored in memory, which is convenient for the robot to quickly clean and deburr. According to the coordinates of image processing holes, the robot can automatically optimize the path and complete the cleaning work.


Chapter 2 explores the portrait studio, which defined many Irish people's experience of family photography for much of the twentieth century. Familial milestones were commemorated by photographs of people in their Sunday best posing stiltedly in front of painted backdrops depicting domestic anywhere-spaces. In particular, it examines two studio portraitists in Waterford in the mid-twentieth century, run by the Poole family and Annie Brophy. Poole catered to the wealthier rural elite, while Brophy's clientele were predominantly the shop owners of Waterford and small farmers of the district. These photographers were united in how they recorded the rhythms of town and country in a way which remained markedly consistent, through these portraits creating an image of a respectability—that profoundly visual quality—in rural Ireland. The repeated patterned similarities between images, in particular, the recurrence of objects and clothes, shows how portraitists kept props, and how those within the frame participated in the restaging of their lives in front of the lens for display both within the home and to circulate amongst extended family. Moreover, close examination of the marks on the negative reveals how blemishes were removed, hair was thickened, and skin was smoothed, and shows how the photography was manipulated in order to create appropriate families for display and viewing. An exploration of the construction of the studio portrait provides a way to explore how social norms were understood, and how the families sitting for these photographs aspired to reach these standards.


The paper presents a survey of foreign researchers" as-sessment of impact of the social origin of a juvenile wrongdoer on his/her delinquent behavior patterns. While admitting that delinquency is more typical of representa-tives of the poor strata of society, the study revealed rea-sons and specifics of juvenile delinquent behavior proper for middle class" wrongdoers.


In this paper we demonstrate a reduction of relative-intensity noise of a mode-locked laser and a gain-switched comb source based on external injection employing a novel optical demultiplexer. Significant performance improvement is demonstrated in 3.125GBaud, 12.5GBaud and 28GBaud PAM-4 systems.


The facilities and research activities of the University of Wisconsin's Center for X‐ray Lithography (CXrL) are outlined. We discuss recent modifications to the two x‐ray lithography beamlines operated by CXrL at the Aladdin storage ring. Ongoing research in various aspects of x‐ray lithography, including photoresist characterization, mask stability and distortion studies, and modeling of the x‐ray lithography process are summarized. We present plans for the expansion of the CXrL research facilities.


Objective:To assess occupational stress of Beijing women doctors and correlative influence factors.Methods:A test of occupational stress and work ability was carried out with revised occupational stress inventory (OSI-R) and work ability index (WAI) for 300 women doctors.Results:The level of occupational stress and strain increased with age, however, personal resources decreased. Women doctors with high education had higher strain than those with low education. The score of occupational role and strain were higher in married, divorced than unmarried (P0.05).The major influential factors of personal strain, interpersonal strain, physical strain were occupational roles, role boundary, rational, self-care.The major influential factors of vocational strain were occupational roles, role overload, education category, rational, physical environment, responsibility. The major influential factors of psychological strain were occupational roles, role boundary, personal resources, role ambiguity.The primary influential factors of work ability for women doctor were hospital's class, role overload, role insufficiency, vocational strain, physical strain and rational conduct.Conclusion:For women doctors, different measures should be taken to reduce the occupational stress as so to improve their work ability.


A three-dimensional finite element model for analysis of metal flow, thermal and microstructural evolutions during hot bar rolling is presented. The heat transfer coefficients at the bar surface are allowed to vary as it is assumed that the bar is either in the air or in contact with the rolls. The microstructural model includes the possibility of both dynamic and static recrystallizations and grain growth during interpass time. Hot rolling process of a square bar in square-diamond-square-square pass sequence is analyzed. Data of temperature, strain and strain-rate distributions are used to compute the microstructural evolution in each pass. The predictions of the model are validated by comparing the calculated results with experimental data available in the literature


The village of Sidetapa uses an oral agreement system in selling its produce which is only based on good faith. The factor that causes people to still use oral agreements is the low level of education and habits so that it can cause problems that will occur in the future due to the absence of a written agreement. The purposes of this study are to determine the application of the principle of good faith in the sale and purchase of agricultural products in Sidetapa Village, Buleleng Regency as well as legal liability for default in the sale and purchase transactions of agricultural products that are not in good faith. The research method in this is an empirical research method with a sociological approach. The data sources used are primary and secondary legal sources. Data collection techniques were carried out by observation, interviews and literature study which were then presented in qualitative form. The results of the study reveal that every agreement must be based on good faith as in the sale and purchase agreement of agricultural products in Sidetapa Village. This agreement system is effective because it is quite simple and easy to implement. This verbal agreement does not rule out the possibility that someone does not default, if there is a default in buying and selling in the village of Sidetapa, the settlement is in a familial way.


The footman moth genus Birketsmithiola Krüger, 2015 is reviewed and five new species are described: B. kruegeri sp. n. (eastern D.R. Congo), B. kingstoni sp. n. (Malawi), B. smithi sp. n. (Zambia and Malawi), B. nakuru sp. n. (Kenya), and B. bvumba sp. n. (Zimbabwe). Eilema sanguicosta var. nyassana Strand, 1912 previously considered as an unavailable name is restored and upgraded to species level: B. nyassana (Strand, 1912), stat. rev. Lectotypes for Ilema sanguicosta Hampson, 1901 and Eilema sanguicosta var. nyassana Strand, 1912 are designated. Adults together with male and female genitalia of all Birketsmithiola species are illustrated.


A recent neuropsychological study of patients with postencephalitic amnesia raised the possibility that limbic regions within the medial temporal lobe might be important for forming cross-modal associations. The present study evaluated cross-modal matching in amnesic patients with damage to the hippocampal formation or the diencephalon. The patients with hippocampal formation damage were fully intact at cross-modal matching (both tactile to visual and visual to tactile). Two additional (non-Korsakoff's) patients with diencephalic amnesia also performed normally at cross-modal matching. Finally, patients with Korsakoff's syndrome did not exhibit a cross-modal deficit, but they did perform poorly in some task conditions— specifically, when a stimulus examined factually had to be matched to a visual stimulus. The results indicate that severe memory impairment can occur without affecting cross-modal performance.


This study demonstrates a novel tri-axial piezo-resistive tactile sensor vertically integrated with a inductive proximity sensor using standard CMOS process (Fig. 1). Normal and shear loads sensing capabilities are achieved by measuring the signal changes of four piezo-resistive cross beams. The proposed sensor design has three merits: (1) the tri-axial tactile sensing unit and the proximity sensing unit can be vertically integrated on one chip, (2) normal and shear loads can be detected by four discrete piezo-resistive sensing elements, (3) the footprint of the chip can be reduced due to the vertical integration of sensing elements. The measurements demonstrate the capabilities of tactile sensing for both normal and shear loads and proximity sensing. The testing results indicate that the proposed tri-axial piezo-resistive tactile sensor shows the normal load (Z-axis) sensitivity of 0.55 mV/N, the X-axis shear load sensitivity of 1.3 mV/N, and the Y-axis shear load sensitivity of 0.76 mV/N.


The propensity of men to reject influence from women and individual differences in this tendency were examined in the present report as potentially related to two types of domestically violent men. We operationalized rejection of influence in sequential analyses of emotional behavior during a 15 min marital interaction. In our previous research, we identified two types of batterers: Type-1, whose heart rates decelerated below baseline during the marital interaction; and Type-2, whose heart rates accelerated. We found that only Type-1 husbands reject any and all influence from their wives. We postulate that Type-1 batterers reject influence as a means of maintaining power and control. Aggr. Behav. 23:375–388, 1997. © 1997 Wiley-Liss, Inc.


The study on the thermal history in Tazhong area is the indispensable composition of the studies on hydrocarbon-generating history and reservoir forming history and resource evaluation. Thermal histories of three wells of TC1, TZ12 and TZ45 in this area are obtained by the inversion calculation of the measurement data of fission track and vitrinite reflectance. The comprehensive research results of the authors and previous researchers show that, since Paleozoic Era, palaeo-geotherm in Tazhong area has decreased on the whole, but there are two higher palaeo-geotherm stages——Cambrian to early Ordovician period, and Permian period. The palaeo-geotherm gradient is 3.2~3.5 ℃/100m in early Ordovician Period and Cambrian Period, and it decreases distinctly from then on. In Carboniferious Period, the palaeo-geotherm increases a little, and the palaeo-geotherm gradient could be up to 3 ℃/100m in Permian period. In Mesozoic Era, the palaeo-geotherm gradient steadily decreases, and it is about 2.5 ℃/100m at the end of Mesozoic Era. In Cenozoic Era, the gradient changes a little. Now, it is about 2.2 ℃/100m.


We examined cardiac function in a novel TG rat model of cardiac specific overexpression of α1A‐adrenergic receptors (α1A‐ARs). Left ventricular (LV) function was studied in anesthetized TG rats and wild type littermates (NTLs), and heart rate (HR) regulation by telemetry in conscious rats. Cardiac hemodynamics, determined using micromanometry (LV pressure and dP/dt) and echocardiography (ejection fraction, EF), revealed enhanced contractility in TG rats (n=6) vs NTLs (n=7) (+dP/dt: 9752± 159 vs 8067±306mmHg/s, p<0.01; EF: 87±1.2% vs 74±0.7%, p<0.01, respectively), where as LV systolic pressure was not different (122±5 vs 124±6 mmHg, respectively). HR, however, was significantly lower in TG rats vs NTLs (293±5 vs 327±10 bpm, p<0.05), due both to decreased sympathetic drive (diminished HR fall to β‐AR blockade with propranolol, 5 mg/kg: −3±1 vs −11±2 bpm, p<0.05, respectively) and enhanced parasympathetic tone (increased HR rise to muscarinic receptor blockade with atropine, 4 mg/kg: +35±3 vs +23±2 bpm, p<0.05, respectively). Thus, cardiac α1A‐ARs overexpression in the rat results in a novel model of enhanced LV contractility and autonomically decreased heart rate.


The effectiveness of our classification and prediction method for transmembrane helix configurations of membrane proteins by replica-exchange simulations is tested with glycophorin A transmembrane dimer. Replica-exchange simulations can sample wide configurational space without getting trapped in local-minimum free energy states and we can find stable structures at low temperatures. We classify low-energy configurations into clusters of similar structures by the principal component analysis. These clusters are identified as the global-minimum and local-minimum free energy states. Our classifications revealed that there are only two major groups of similar structures in the case of the simulation with the dielectric constant e= 1.0 and five such groups in the case of e= 4.0. The global-minimum free energy state in the case of e= 1.0 is very close to the structure of the NMR experiments and the prediction was successful, while in the case of e= 4.0 not the global-minimum but a local-minimum free energy stat...


Abstract : Domestic support for the war is often mentioned as one of the key battlegrounds of the Afghan conflict. A variety of explanations have been put forward in the media and in the political realm to explain why this war, which once commanded overwhelming popular support in almost all participating countries, is now opposed by a majority, even in the United States itself. Casualties, lack of equitable multilateral burden sharing, confused and shifting rationales on the part of the political leadership for the war and a "contagion" effect from the unpopularity of the Iraq war have all been cited at one time or another.


In this paper, we have investigated the peristaltic motion with heat and mass transfer through a vertical channel divided into two equal regions, the right region filled with a clear non‐Newtonian fluid obeying the Williamson model and the left region with a nano‐Williamson fluid. The system is stressed by a gravity force with a uniform external magnetic field. The problem is modulated mathematically with a system of coupled nonlinear partial differential equations that describe the velocities, temperatures, and concentration of the fluids. The system of nondimensional, nonlinear, and partial differential equations is solved analytically with the homotopy perturbation method after using the approximations of low Reynolds number and long wavelength. The obtained solutions are functions of the physical parameters of the problem. Then, the effects of these parameters on velocities, temperatures, and concentration are discussed numerically and illustrated graphically through a set of figures. It is found that the parameters play an important role in controlling the solutions. It is shown that the stream function decreases on the left side and increases on the right side with an increase in the Wissenberger parameter and thermal conductivity ratio. Also, the temperature in the two regions increases with an increase in the thermophoretic parameter, whereas it decreases with an increase in the Brownian motion parameter. Furthermore, the concentration increases with an increase in the Brownian motion parameter and decreases with an increase in the thermophoretic parameter.


Label is defined as a display of written, printed or graphic matter on the container or the package of the container. The design of the label should be such that the consumer can read and understand the information without any visual discomfort. The aim of the study was to conduct ergonomic evaluation of labels in terms of design features, information efficacy, mandatory guidelines and find out consumers perceived level of visual comfort while reading the label. One hundred and twenty consumers who frequently purchased ready to eat meal products formed the sample for investigation. The visual comfort while reading was measured in terms of physical and psychological visual stress symptoms. The design features were evaluated in terms of size and colour of the font, placement of label, clarity of language, colour of label background, label attraction, reflective surface package, visibility of essential information. The associations and relationship between variable were analyzed by using Chi square and Anova. The consumers perceived visual discomfort while continuously reading labels. Consumers with defective eye sight perceived visual discomfort at higher level. The design of the label has not met the visual requirements of human eye. Font size and visibility of essential information were the defects in label design. Consumers who experienced visual stress did not read the label. To attract the attention of consumers the food manufacturers should adopt ergonomic principles in designing label. The study brought out recommendations on label designing as per the user requirements.


The blood perfusion is to point to the blood draw out and the process of purification,it was initially used in the treatment of patients with acute poisoning,and is still is the most major applications.But with the continuous development of medical science innovation,found that the blood perfusion in the treatment of some other aspect of the disease also play a significant role.Now the technology was gradually used in the treatment of uremia,critical disease,lupus erythematosus,heavy-duty hepatitis patient such as emergency treatment.


"Clickbait" has become a common form of online media, and headlines designed to entice people to click are frequently used by both legitimate and lessthan-legitimate news sources. We present the results of a pair of experiments with di↵erent sets of subject pools: one conducted using Facebook ads that explicitly target people with a high preference for clickbait, the other using a sample recruited from Amazon's Mechanical Turk. We estimate subjects' individual-level preference for clickbait, and randomly assign sets of subjects to read either clickbait or traditional headlines. We find that older people and non-Democrats have a higher "preference for clickbait," but find no evidence that assignment to read clickbait headlines drives a↵ective polarization, information retention, or trust in media.


An experimental system was built to test the wall temperature and heat flux of separated semi-open thermosyphon(OPS), mixed semi-open thermosyphon(OPM) and inserted tube semi-open thermosyphon (OPT). The heat transfer coefficients of the condensation segment and the evaporation segment and the total heat transfer performances of the above three types of semi-open thermosyphons were compared. The results show that the changes of wall temperature and heat transfer coefficient of OPM and OPS are big with the length of pipe, and those of OPT are a little consist with the length of pipe. The working performances of the evaporation segment of three types of semi-open thermosyphons are basically the same, but their working limits are different. The total heat transfer performances of three types of semi-open thermosyphons are almost the same at the same working conditions.


Technological advances in Intensive Care have allowed a drop in the number of deaths among hospitalized patients, while the prevalence of diseases that require Intensive Care Units has increased significantly. Therefore, the Post-Intensive Care Syndrome (PICS) has become a reality within daily care to be investigated, in search of clarifications that help in a better understanding of the issue and promote the reduction of this situation. The aim of this study is to review the literature on PICS, discussing its main aspects, predictive factors, sequelae, management and prevention. Among the patients after discharge from the ICU, it is observed, mainly, the impairment of cognition, psychiatric disorders and physical function. These domains are affected in different areas, and may trigger signs and symptoms that reduce the functional capacity and quality of life of the affected subjects. In addition, there are factors that support the development of the Syndrome, which may or may not be modifiable. The mitigation of modifiable events associated with post-discharge multidisciplinary care can contribute to easing the development of PICS, with Primary Care being an ally in the prevention and early screening of the Syndrome.


Abstract : In December 1993, the Foreign Minister of Poland, Andrcej Olechowski, told an audience at the Center for Strategic and International Studies, "... at the forthcoming NATO summit President Clinton will articulate his vision of trans-Atlantic security and prosperity, and a strong and unbreakable link between the United States and Europe. And we must insist that Poland...be included in such a Europe." At a later point in his speech he added that Poland "has to be anchored in the North Atlantic Treaty Organization." This paper will address reasons for Poland's request, what NATO offered in reply, possible ramifications of NATO's actions, and policy options open to the United States in this arena. Poland does not stand alone in its search for security under the NATO umbrella. Several ex-Warsaw Pact countries have made the same request. This paper will focus on Poland because it has led the nations of East-Central Europe in the transition from communism to a free market system and will probably act as the forerunner in that region's national security dealings. For that reason, even though the paper will be looking primarily at Poland, the issues discussed here also will pertain to the majority of East-Central Europe.


Energy consumption is the core issue in wireless sensor networks (WSN). To generate a node energy model that can accurately reveal the energy consumption of sensor nodes is an extremely important part of protocol development, system design and performance evaluation in WSNs. In this paper, by studying component energy consumption in different node states and within state transitions, the authors present the energy models of the node core components, including processors, RF modules and sensors. One of the major issues in wireless sensor networks is developing a routing protocol which has a significant impact on the overall lifetime of the sensor network. The network area is divided into same sized small–small regions. Sensor nodes are randomly deployed in each predefined sub-area. Each region will have its region head (RH) and multiple member nodes. The member nodes in a specific region will send the data to the RH. RH within the region will be elected by distributed mechanism and will be based on fuzzy variables. It was found that the proposed algorithm gives a much improved network lifetime as compared to existing work. Based on our model, transmission tuning algorithm for cluster-based WSNs has been proposed to balance the load among cluster heads that fall in different regions. This algorithm is applied prior to a cluster algorithm to improve the performance of the clustering algorithm without affecting the performance of individual sensor nodes.


In the present study we redescribe the systematics of some holothurian species collected from different localities of the Algerian coastal waters. Morphological (anatomical and endoskeletal) and previous molecular studies showed the presence of two distinct morphotypes of Holothuria (Holothuria) tubulosa (A & B). Morpho type A corresponds to the classical Holothuria (Holothuria) tubulosa (Gmelin 1791), described by Koehler (1921); while morpho type B, we believe, represents a species new to science with characteristics significantly different from those of Holothuria (Holothuria) tubulosa A. Statistical methods (hierarchical clustering) confirm significant differences between these two morpho types. To better visualize these differences, measurements made on ossicles of Holothuria (H.) tubulosa A & B (Holothuria algeriensis nov. sp.) were compared to other species that were present in our collection including the classical Holothuria (H.) tubulosa from Banyuls sur Mer (France) and the north-eastern Atlantic species, Holothuria (Roweothuria) arguinensis (Koehler & Vaney, 1906) recently recorded from Algerian waters and the Mediterranean Holothuria (Roweothuria) poli (Delle Chiaje, 1824). We conclude that the two morpho types of H. (H.) tubulosa are significantly different to warrant the recognition of a new species for the B form herein called H. (H.) algeriensis nov. sp.


AbstractThe effects of an aqueous extract of Lagenaria breviflora Robert (Cucurbitaceae) fruit on pregnant and non-pregnant isolated rat uteri have been investigated.The aqueous extract of L. breviflora fruit induced concentration-dependent, oxytocin-like contractions of the gravid and non-gravid isolated rat uteri. The extract-evoked contractions of the uterine strips examined were not modified by the standard antagonists used. The aqueous extract of L. breviflora fruit failed to contract the guinea-pig isolated ileum, whereas acetylcholine and histamine contracted this mammalian gastro-intestinal tract smooth muscle in a dose-related manner. The plausible pharmacological implications of these findings are discussed.


Cryptography hardware design is a key challenge towards the confidentiality advance in the prominent field of the internet of things (IoT). The rise of IoT embedded devices boosts the demand for power- and area- efficient solutions for cryptography hardware. The higher the robustness of the cryptography algorithm is, the higher are the hardware complexity, the circuit area, and energy consumption. Asymmetric algorithms are a particular class widely employed in ultra-secure cryptosystems. The high time-hardness to break the private-key in asymmetric algorithms is a result of its high mathematical complexity. RSA is an asymmetric algorithm that performs successive modular multiplications to encrypt and de-encrypt the information. Therefore, arithmetic operators are the most significant part regarding circuit area and power dissipation. This work evaluates a design space exploration for power- and area-efficient hardware VLSI design in the modular Montgomery multiplier employed in the RSA algorithm.


The invention discloses a chicken claw cutting machine comprising a rack, a first cutting device, a first conveying device, a second conveying device, a second cutting device and a power mechanism, wherein the first cutting device is provided with a first knife shaft and a second knife shaft; at least one upper knife wheel penetrates on the first knife shaft; at least one lower knife wheel penetrates on the second knife shaft; the first conveying device is provided with a rotating shaft C; at least one belt pulley C is arranged on the rotating shaft C; the belt pulley C and the lower knife wheel are connected through a three-finger chicken claw conveying belt; the second conveying device is provided with at least one main bone claw conveying belt perpendicular to the three-finger chicken claw conveying belt and comprises a plurality of stop blocks which are used for stopping main bone claws, arranged on the conveying surface of the main bone claw conveying belt in parallel and perpendicular to the moving direction of the main bone claw conveying belt; the second cutting device is provided with a third knife shaft and a fourth knife shaft; at least one upper knife wheel I is arranged on the third knife shaft; and at least one lower knife wheel I is arranged on the fourth knife shaft. The chicken claw cutting machine has the advantages of energy conservation, high yield, low failure rate and good effect.


Complications of diabetic foot disease have become more prevalent since advances in the treatment and increased life expectancy. Herein we review the clinical presentation and the outcome in patients with diabetic foot disease (DFD) presenting in our hospital which is located in a rural area. One hundred and seventy three patients with the mean age of 60 years, both male and female were included in the study. Various conditions included under the heading of 'DFD' were managed in appropriate manner. Patients were followed up over a period, and outcome was noted to complete the study. Out of 173 patients 166 had Type-II diabetes while 7 had Type-I. Mean duration of diabetes was 13 years.Nineteen percent patients had neuropathic ulcer, 6.35% patients had neuroischaemic ulcer, and 10.98% feet were ischaemic (5.78% ischaemic ulcer + 5.2% tissue devitalization). Major lower limb amputations were performed in 17.91% of patients.


Abstract 2437 Introduction/Background: Wilms tumor 1 (WT1) gene encodes for a zinc finger-containing transcription factor thought to play a role in differentiation, cell cycle regulation and apoptosis. WT1 expression is developmentally regulated and tissue-specific, with adult expression maintained in kidney cells and early CD34+ hematopoietic progenitor cells. Inactivating mutations of this tumor suppressor gene are well described in sporadic Wilms tumor and as germline mutations in WAGR and Denys-Drash syndromes. Approximately 10% of adult and pediatric patients with cytogenetically normal acute myeloid leukemia (CN-AML) harbor WT1 mutations. Some studies suggest that patients with WT1 mutations may have a worse overall prognosis, particularly in combination with other poor prognostic indicators, such as FLT3 ITD mutations. Interestingly, WT1 and FLT3 ITD mutations are commonly found together, suggesting they may cooperate to cause AML. Despite these clinical observations, the functional contribution of WT1 mutations to leukemogenesis, both alone and in cooperation with FLT3 ITD , is still largely undetermined. Methods/Results: Ba/F3 cells were stably transfected with the WT1 gene, including 3 different engineered mutated vectors: two missense point mutations (WT1mut 101 and WT1mut 146 ) and one nonsense insertional mutation (WT1mut 126 ), which produces a truncated protein. These mutations have been described in pediatric patients with acute leukemia. The expression of each WT1 vector was confirmed by PCR and cDNA sequencing. We compared the proliferative rate of WT1 wildtype (WT1wt) to WT1mutated (WT1mut) transfected cells using trypan blue cell counting, and saw an early increased proliferative rate for high-expressing WT1mut compared to WT1wt and WT1 empty vector (EV). To further investigate these differences, we performed cell cycle analysis with propidium iodide (PI) staining. After synchronizing all cell lines by arresting cells in G0-G1 phase, the cells were seeded at equal concentrations and assayed for cell cycle changes at various time points. Interestingly, all WT1mut cell lines consistently showed earlier entry into S phase and therefore a decreased G1/S ratio at 24 hrs after synchronization, compared to EV and WT1wt (Fig A). This suggests that the "check-point" controlling entry into S phase is altered in cells expressing WT1 mutations, which manifests as a proliferative advantage in these cells. Next, we stably transfected Ba/F3 cells with a FLT3 ITD construct, and co-transfected additional cells with both WT1mut and FLT3 ITD constructs. All cells were synchronized by arresting in G0-G1 phase, achieved with 24 hrs of serum and cytokine starvation and treatment with 20nM of CEP-701 (ensuring G0-G1 arrest of cells with FLT3 vectors). The cells were then washed and re-suspended in serum and cytokine-containing media, and seeded at equal concentrations. We observed that FLT3 ITD cells and WT1mut 126 cells had decreased and nearly equivalent G1/S ratios at early time points compared to EV and WT1wt cells, conferring similar early proliferative advantages for cells with these mutations. Interestingly, we found that cells co-transfected with both mutations enhanced this effect: the absolute number of WT1mut 126 +FLT3 ITD cells undergoing transition into S phase was increased and this effect was seen at an earlier time point compared to WT1mut 126 , FLT3 ITD , WT1wt or EV cells (Fig B). Conclusions: The functional and contributory role of WT1 mutations in leukemogenesis has yet to be characterized. Our preliminary in vitro data with a cell line transfected with WT1 vectors suggests that cell cycle regulation, and therefore proliferation, is aberrant in cells expressing mutated WT1. Consistent with previous reports, our data reaffirms a proliferative advantage in cells transfected with FLT3 ITD mutations. We showed that these cells transition to S phase at an early time point, conferring an early proliferative advantage, and do so at an equivalent rate and time to WT1mut cells. In addition, we found that cells co-transfected with both WT1mut 126 +FLT3 ITD demonstrated an earlier and more pronounced entry into S phases compared to either individual mutation alone. These observations deserve further investigation, as they may help explain how mutated WT1 contributes to the initiation and progression of leukemia, and how WT1 and FLT3 ITD mutations may cooperate in leukemogenesis. Disclosures: No relevant conflicts of interest to declare.


Cytomegalovirus (CMV), a β‐herpesvirus, has been implicated in the inflammation associated with several vascular diseases. CMV upregulates adhesion molecules and induces leukocyte adhesion in vitro. This study examines the role of P‐selectin in the microvascular inflammation that occurs in hypercholesterolemic mice infected with CMV. C57Bl/6 mice were mock‐inoculated or infected with murine CMV, and 5wk later placed on normal diet (ND) or high cholesterol diet (HC) for 4wk. Separate CMV‐HC groups received P‐selectin blocking Ab 18 h before observation. Acetylcholine‐induced arteriolar vasodilation and leukocyte adhesion in postcapillary venules were monitored in the cremaster muscle. CMV alone, but not HC alone, impaired arteriolar function. However, leukocyte adhesion was only elevated when CMV was combined with HC. Pre‐treatment of CMV‐HC mice with P‐selectin Ab reduced leukocyte adhesion to levels observed in mock‐ND mice. Blocking P‐selectin also conferred protection against arteriolar dysfunction in this group. These findings implicate P‐selectin in the leukocyte recruitment elicited by CMV infection combined with hypercholesterolemia, and suggest that P‐selectin contributes to arteriolar dysfunction through a pathway that is independent of leukocyte adhesion in these vessels.


The cultural history and developing present condition of apple industry in Sichuan were reviewed,and systematic analyzed the advantages and problems from these sides which of the ecosystem geography weather,apple belongs to a plant resource and produce zone work force resource and domain horizontal of apple in Sichuan.Had a foothold with the outstanding ecosystem advantage and the competitive edge,we would develop following works.Such as:fetching in and making use of a domestic and international apple germplasm resources;establishing germplasm resources pool;particularly sieving new species from Red Delicious bud sport clones and precocious Fuji bud sport clones;creating short anvil intensive good heavy system.Aftertime,the developing objects of apple industry were reforming the low effect apple park,layout and constructing of excellent living region,enhancing cultivation technique,efficiently and intensive planting the dwarf rootstock,and developing the postharvest technique.


toms may be somewhat coloured by the woman's physical condition. Still it is the character of the insanity and not the particular time it arises which settles the exact diagnosis. The most common forms occurring at these times are acute confusional insanity, manic depressive insanity (especially melancholia) and the katatonic variety of dementia prieco» and all of these have a relatively favourable prognosis. In just the same way, such a thing as "climacteric insanity" is not recognized in modern textbooks. Insanity arising in women about the fourth and fifth decade is usnnllv involutional melancholia (really a sub-species or'manic depressive insanity), paraphrenia or paranoia, the prognosis of all of which is unfavourable, especially the two latter. Returned Soldier Patients.


The citation given in reference [98] is incorrect. It should be Berner et al 2010 Phys. Rev. Lett. 110 247601.


Abstract : A field experiment was conducted to determine whether a circular bracketin sight mounted on a standard M16Al rifle could enhance the effectiveness of the weapon in a short-range, quick-fire environment against a moving target. Circular bracket sights of 1.32 and 2.64 ins. in diameter were used. Human silhouette targets appeared moving along a track at 6 mph. at distances of 25 and 50 yds. and remained exposed for approximately 2.5 secs. Subjects were infantrymen who engaged the target (single-shot) with each sight and at each direction of target movement (right-left) and range. An unmodified M16Al sight was tested by the same subjects for comparison using standard quick-fire techniques.


Electrocrystallization of the novel π-electron donor (ethylenethio)(ethylenedithio)-tetrathiafulvalene (ETEDT-TTF) with trihalide anions has given rise to a new family of radical cation salts with insulating properties, [ETEDT-TTF]X, and conducting properties, ETEDT-TTF]X 0.42 where X = I 3 - or I y Br 3-y -. According to X-ray data, in the isostructural completely ionic [ETEDT-TTF]X salts, the donor radical cations are strongly dimerized, with an interplane distance of 3.310-3.317 A, and the mixed-valence [ETEDT-TTF](I 3 ) 0.42 salt is formed by segregated radical cation and anion layers alternating along the b axis. The latter salt exhibits semiconductor behavior with a high room-temperature conductivity of 24 S.cm -1 . The large angle between the molecular planes of the donors in neighboring stacks precludes the possible metallic behavior of this salt. Interestingly, nanocrystals of the mixed-valence salts are the conducting component of new bilayer (BL) composite films that have been generated via the ETEDT-TTF + I 2 and ETEDT-TTF + IBr chemical reactions. The structure and composition of the conducting layers of these new BL films were confirmed by X-ray, EPR, and Raman spectroscopies. Similarly to the single crystals, these composite materials exhibit semiconducting behavior with a room-temperature conductivity ranging from 0.25 to 2.5 S.cm -1 . SEM and NIR studies of the film samples were also carried out.


The calculation of rotationally inelastic collisions and momentum-transfer cross sections is treated for N₂. The rotationally inelastic differential, integrated, as well as the momentum-transfer cross sections are presented.


This paper uses quantitative analytics to study talk-based participation in 100 mathematics classrooms across one racially diverse urban school district in the USA. Using the EQUIP observation tool and hierarchical linear modeling, we characterize the quantity and quality of participation for students across 3025 coded turns, by race and gender. We found that in general, boys participated significantly more than girls. We also found that Latinx and Asian/Pacific Islander students had significantly fewer turns than Black and White students. To interpret these findings in context, we analyzed interviews from 29 district leaders using a poststructural framework organized around D/discourse.


Community-acquired pneumonia remains the leading infectious cause of death around the world. Many factors influence the prognosis and outcome of this disease. Compared with healthy individuals, patients with diabetes mellitus are at increased risk of respiratory tract infections, such as community-acquired pneumonia. Diabetes mellitus contributes to the development of pulmonary thrombotic microangiopathy, changing the functional state of the lungs. In numerous studies involving patients with diabetes mellitus, data on the state of the lungs were obtained by instrumental tests, such as spirometry, ventilation / perfusion scintigraphy, perfusion computed tomography, and diffusing capacity of the lungs for carbon monoxide. In patients with community-acquired pneumonia, diabetes mellitus causes vague clinical symptoms, leads to a severe course of the disease, and contributes to development of complications. Diagnosing the functional state of the lungs in patients with community-acquired pneumonia against the background of diabetes mellitus has not been studied.


The economy of the buildings is a new kind of emerging economy in the development of our country's urban economy, and has become an important branch of the city's rapid economic growth, being a bright spot. This paper, taking the Nanjing Road shopping district in Shanxi road as the study object, through the development of research buildings, selecting three typical commercial office buildings, by analysis and comparison of the basic situation, tries to find the road district of Shanxi's economic development characteristics of buildings and making recommendations.


Primary processing is the most important aspect in enhancing the added value at farm business level, but some farmers have not done yet. This study aims to analyze the income of arabica coffee farm business, the difference in farmers' income that sells coffee in parchment and cherry red, and  the added value of selling in parchment. Data were analyzed with Revenue Cost Ratio (RCR), Independent Sample t Test, and added value analysis method of Hayami et al. (1987). The results showed that arabica coffee farming with parchment had a higher RCR and was significantly different from cherry red, and which sold both parchment and cherry red. Income of farmers who sell parchment is differs significantly from who sell cherry red and those who sell both parchment and cherry red.  The added value of primary processing is 30%, while the income of family labor from the primary processing is 69%.


STABILITY OF SC COMPOSITE AT RAPID CURRENT CHARGING AND AGAINST PULSED HEATING E.Yu. Klimenko and N.N. Martovetsky 1.V.Kurchatov Institute of Atomic Energy, 123182 Moscow, USSR Abstract Numerical analysesof stability of SC wire have been carried out for rapid charging. It was discovered that the dependence of maximal current on charging rate was nonmonotonous. At very rapid charging one could input higher current before a wire would be heat up to the critical temperature. distribution was studied numerically. Pulsed energy value which initiates a flux jump and a consequent transition to the norLnal state may be much lower than socalled adiabatic energy and pulsed energy dependence on transport current is weaker. Wire stability against pulsed heating at nonuniform current Introduction The stability of SC multifilainentary wire at rapid charging or discharging is important for pulsd and AC applications.


Starting from ethyl beta-carboline-3-carboxylate (beta-CCE), 1, a modest inhibitor of type 5 phosphodiesterase (PDE5), a series of functionalized tetrahydro-beta-carboline derivatives has been identified as a novel chemical class of potent and selective PDE5 inhibitors. Optimization of the side chain on the hydantoin ring of initial lead compound 2 and of the aromatic ring on position 5 led to the identification of compound 6e, a highly potent and selective PDE5 inhibitor, with greater selectivity for PDE5 vs PDE1-4 than sildenafil. Compound 6e demonstrated a long-lasting and significant blood pressure lowering effect after iv administration in the spontaneously hypertensive rat model but showed only moderate oral in vivo efficacy.


Objective: We developed a clinical decision support tool to help physical therapists (PTs) address the varied expectations and recoveries of the total knee arthroplasty (TKA) population. The tool uses a ''people-like-me'' algorithm to predict recovery after TKA. The purpose of this study was to explore patients' and clinicians' perceptions and experiences with the tool during rehabilitation after TKA. Methods: We piloted the tool in 2 outpatient physical therapy clinics. We conducted in-depth semi-structured interviews with 1) patients who underwent TKA and were exposed to the tool during rehabilitation and 2) clinicians who used the tool with patients after TKA. Two members of the research team coded the interview data using a descriptive content analysis. Results: 16 patients and 10 clinicians were interviewed. We identified 4 common themes: 1) Expectations: most patients and clinicians felt the tool provided patients with valuable feedback for managing recovery expectations; 2) Motivation: patients and clinicians felt the tool motivated patients to participate in rehabilitation by providing positive reinforcement and/or a form of competition; 3) Influence on practice: some patients and clinicians indicated that the tool helped guide treatment decisions or provided opportunities for patient education, but most felt it did not influence clinical decision making; and 4) Clarity and comprehension: the majority of patients understood the tool's ''take-home'' message, however, some patients and clinicians felt the use of percentiles, line graphs, and medical jargon decreased patients' clarity and comprehension of the tool. Conclusions: Overall, participants reported that the tool helped to shape patients' expectations for postoperative recovery and increase patient motivation to participate in rehabilitation. Participants had mixed perceptions on how the tool influenced clinical care. Finally, participants identified some limitations in patient comprehension of the tool, which will inform future revisions to the tool to accommodate varying levels of health literacy.


In today's digital age, our borders are no longer simple lines drawn on a map and border crossings do not only take place at distinct points of entry along those lines. From a business and security perspective, to operate efficiently in this environment of fluid border crossings, border service organisations require visibility of who or what is entering the country, as well as ensuring that people who are meant to leave by a certain date do so. Sharing data is at the heart of this. However, the problem that the UK faces, particularly as it prepares to leave the European Union, is that current systems for immigration and customs control have evolved over 50 years, layering legacy software system upon legacy software system. Organisations and government departments involved in the border process can find themselves working in information silos, meaning that data is being shared inefficiently. Furthermore, a wholesale revamp of the UK's customs and immigration systems isn't practical or cost effective SIMON DAYKIN, CHIEF TECHNOLOGY OFFICER, LEIDOS


This paper introduces an encryption and decryption techniquehopping code techniques.On the basis of analyzing its excellence,the authors have developed a reliable and secure intellectualized system of garage guarding against theft by using HCS301 encoder and PIC16C54 MCU supplied by Microchip Inc.


Granular activated carbon (OSAC) which was derived from olive oil industrial solid waste was chemically activated with different concentrations of phosphoric acid. OSAC-materials were evaluated for their ability to remove phenol from aqueous solution in a batch technique. Adsorption isotherms were determined and modeled with five linear Langmuir forms, namely the Freundlich, Elovich, Temkin, Kiselev and Hill-de Boer models. The experimental data for the adsorption of phenol onto OSAM-materials were fitted well with the Langmuir-1 and 2, Freundlich, Kiselev and Hill-de Boer models. Adsorption was carried out on energetically different sites as localized monolayer adsorption and was an exothermic process. The uptake of phenol onto OSAC increased in the following order: OSAC-80%> OSAC-70%> OSAC-60%; the maximum adsorption capacities of phenol were found to be 114.416, 125.628 and 262.467 mg/g onto OSAC-60%, OSAC-70% and OSAC-80%, respectively. On the other hand, OSAC-80% was used as a good adsorbent for the removal of phenol and Cd2+ as co-pollutants from waste aqueous solutions. 80.25% of phenol and 50.66% of Cd2+ can be simultaneously removed by OSAC-80%.


This study is proposed the novel PPG sensor device and the signal processing method to replace the acceleration sensor that is used to reject motion artifacts contained in photoplethysmography(PPG). The proposed method is to reject motion artifacts by an adaptive filter based on the estimated motion artifact by using a blue LED light. To evaluate the performance of the proposed method experimentally, We did design a novel sensor consisted of blue/red LEDs and photo-sensor and implemented, and then rejected the motion artifacts by using an adaptive filter and the implemented sensor. In the results of the experiments, it is shown that the proposed sensor device and signal processing can reconstruct the PPG signal despite the occurrence of motion artifacts, and also that the SNR was 4.5 times of moving average filter. According to the experimental results, the proposed method can be applied to design a low-cost device.


The invention provides a method and device for managing a service usage right. The method for managing the service usage right includes the steps that when whether a client side has a designated service usage right needs to be verified, whether the client side can be connected with a verification authentication server is judged; when it is judged for the first time that the client side cannot be connected with the verification authentication server, the client side is authorized to have the designated service usage right in a preset time period. By means of the method and device for managing the service usage right, when the client side cannot be communicated with the server, normal use of the client side can be guaranteed, and meanwhile, the problem that a verification mechanism is broken when the usage right of the client side is verified through a mobile application server is avoided.


Nature around notions of order and design, which Arnold Berleant criticizes through an 'aesthetic of engagement', and Noel Carroll seeks to complement with an 'arousal model' of being moved by Nature. Berleant seeks to extend the aesthetic away from disinterested contemplation, injecting a more corporeal sense, but insists on equating satisfactory engagement with a sense of unity. Here, as elsewhere, there is little


We consider a stochastic process based on the iterated prisoner's dilemma game. During the game, each of n players has a state, either cooperate or defect. The players are connected by an 'interaction graph'. During each step of the process, an edge of the graph is chosen uniformly at random and the states of the players connected by the edge are modified according to the Pavlov strategy. The process converges to a unique absorbing state in which all players cooperate. We prove two conjectures of Kittock: the convergence rate is exponential in n when the interaction graph is a complete graph, and it is polynomial in n when the interaction graph is a cycle. In fact, we show that the rate is O(n log n) in the latter case.


In Phys. Rev. A 74, 030303 (2006), Yung showed that for a one-dimensional spin chain of length $N$ and maximum coupling strength $J_{\max}$, the time $t_0$ for a quantum state to transfer from one end of the chain to another is bounded by $J_{\max} t_0\geq\pi(N-1)/4$ (even $N$) and $J_{\max} t_0\geq\pi\sqrt{N^2-1}/4$ (odd $N$). The proof for even $N$ was elegant, but the proof for odd $N$ was less so. This note provides a proof for the odd $N$ case that is simpler, and more in keeping with the proof for the even case.


A class of inverse eigenvalue problem is proposed for real symmetric positive definite Arrow matrices. Necessary and sufficient conditions for the existence of a unique solution of this problem, as well as the analytic formula of this solution are derived, Our results are on structive, in the sense that they generate an algorithmic procedure to construct the matrix.


This chapter, the fourth of Part One of the book, asks ten questions regarding poverty and the Poverty-Aware Paradigm and answers them. Among the questions are the following: Are people who are busy with basic survival and the attempt to meet their primary existential needs available for emotional therapeutic processes? If structural issues have such a crucial impact on poverty, how can we understand that in the same neighbourhoods, the children of some families manage to escape poverty while others do not? Does poverty-aware social work free people of their responsibility for their situations? How can social workers avoid encouraging dependency among service users?


In this paper we discuss a tool for semantic annotation and search in a collection of art images. Multiple existing ontologies are used to support this process, including the Art and Architecture Thesaurus, WordNet, ULAN and Iconclass. We discuss knowledge-engineering aspect such as the annotation structure and links between the ontologies. The annotation and search process is illustrated with an application scenario.


Increased biological understanding of cancer diseases has resulted in a paradigm shift in the medical treatment of cancer. Despite encouraging advances, most cancer types are still incurable and cancer is the second most common cause of death in developed countries.The high price of cancer drugs is a major challenge to equal access and puts heavy strains on public health care payers. After sharp increases in the 2000s, total expenditures on cancer drugs have levelled off due to patent expiration of many expensive and widely used drugs.Cancer drug utilization studies cover a great variety of topics. Four main research areas are patient adherence, physician adherence to guidelines, effectiveness and safety (outcomes research) and access (market uptake).Most cancer drugs are classified under Anatomical Therapeutic Chemical (ATC) group L. The use of defined daily dose (DDD) as a measurement unit is feasible for oral cancer drugs. As most cancer drugs are administered as infusions or injections at hospitals, usage is commonly measured in milligrams.Drug utilization research in the area of cancer is faced with a lack of data. Comparisons are challenging, as prices and population bases vary across regions. The linkage of registries and health care databases that include cancer drug usage will create improved opportunities in the future. (Less)


Abstract Introduction: Traditionally, open resection with hepaticojejunostomy reconstruction has been the surgical treatment for cases of choledochal cyst. Our center has recently transitioned from open to laparoscopic and hepaticojejunostomy to hepaticoduodenostomy as our preferred method of excision and biliary reconstruction. Methods: This video shows a method adapted at our center to simplify the biliary enteric anastomosis. Results: Complete resection of the choledochal cyst is carried out. A duodenotomy is then made at least 2 cm from the end of the pylorus. A lateral corner retraction suture is then placed through both the bile duct and the duodenum to improve exposure. Two long-lasting monofilament sutures are then cut to 8 to 10 cm each and tied extracorporeally. This united suture is then placed intraabdominally and one needle is passed from outside to inside on the bile duct and the process is repeated on the duodenum with the opposite needle. This allows the previously tied knot to be placed o...


In this article, a process for creating positive behavior support plans for individual students who have difficult behaviors is described. Challenges facing rural educators are presented along with information on the essential elements of behavior support plans. A case illustrates the process used to create a positive behavior support plan for an elementary student with challenging behaviors. Supports for creating and supporting active problem solving teams in rural schools also are describe.


Abstract : The status of scientific communications was evaluated at the U. S. army Biological Laboratories through a questionnaire. Two hundred twenty-five responses provided the source information. Evidence indicates a hazy understanding of good communications, a lack of familiarity with the means of good communications, and a lack of recognition of the close interrelationships among information, management, and operations. Generally speaking, participants recognized these characteristics but questioned their own involvement in an information system rather than in their individual interests (operations). The implied placement of responsibility was on information personnel. Several suggestions are made in regard to the future course of Biological Laboratories' information systems.


INTRODUCTION The Need for Software Engineering Are Software Teams Really Necessary? Software Engineering Software Lifecycles Different Views of Software Engineering Activities Software Engineering as an Emerging Discipline Some Techniques of Software Engineering Standards Commonly Used for Software Development Processes The Year 2000 Problem and Similar Problems Organization of the Book PROJECT MANAGEMENT Sub-Teams Needed in Software Engineering Projects The Nature of Project Teams Project Management Software Project Estimation Project Scheduling Project Measurement Project Management Tools The Role of Networks in Project Management Groupware An Example: Project Management for a Year 2000 Conversion Project REQUIREMENTS Some Problems with Requirements Determination Requirements Elicitation Requirements Traceability Software Architectures and Requirements Reengineering System Requirements Assessment of Feasibility of System Requirements Usability Requirements Specifying Requirements Using State Diagrams and Decision Tables Specifying Requirements Using Petri Nets Ethical Issues Some Metrics for Requirements The Requirements Review The Major Project - Problem Statement The Major Project - Requirements Elicitation The Major Software Project - Requirements Analysis SOFTWARE DESIGN Introduction Software Design Patterns Introduction to Software Design Representations Procedurally-Oriented Design Representations Software Architectures Software Design Principles for Procedurally-Oriented Programs What is an Object? Object-Oriented Design Representations Software Design Principles for Object-Oriented Programs Class Design Issues An Example of Class Development - The String Class User Interfaces Software Interfaces Some Metrics for Design Design Reviews A Manager's Viewpoint of Design Architecture of the Major Software Engineering Project Preliminary Design of the Major Software Project Subsystem Design of the Major Software Project Detailed Design for the Major Software Project CODING The Choice of Programming Language Coding Styles Coding Standards Coding, Design, Requirements, and Change Some Coding Metrics Coding Reviews and Inspections Configuration Management A Management Perspective on Coding Coding of the Major Software Project TESTING AND INTEGRATION Types of Software Testing Black-Box Module Testing White-Box Module Testing Reducing the Number of Test Cases by Effective Test Strategies Testing Objects for Encapsulation and Completeness Testing Objects with Inheritance General Testing Issues for Object-Oriented Software Test Plans Software Integration Managing Change in the Integration Process Performance and Stress Testing Quality Assurance Software Reliability A Manager's Viewpoint on Testing and Integration Testing the Major Software Project Integrating the Major Software Project DELIVERY, INSTALLATION, AND DOCUMENTATION Delivery Installation Internal Documentation External Documentation Design Rationales Installation, User, Training, and Operations Manuals On-Line Documentation Reading Levels A Manager's View of Delivery, Installation, and Documentation Delivery, Installation, and Documentation of the Major Software Project MAINTENANCE Introduction Corrective Software Maintenance Adaptive Software Maintenance Preventative Software Maintenance and the Year 2000 Problem How to Read Requirements, Designs, and Source Code A Manager's Perspective on Software Maintenance Maintenance of the Major Software Project RESEARCH ISSUES IN SOFTWARE ENGINEERING Some Important Research Problems in Software Engineering How to Read the Software Engineering Research Literature APPENDIX: COMMAND-LINE ARGUMENTS REFERENCES


The high temperature clear liquor was abtained by evaporation and separation of part of the solium chloride from the mother liquor which derived from preparation of magnesium hydroxide using ammonia reacting.The salting law of the solution was studied by cooling the solution from 120 ℃ to 20 ℃.The results show that(NH4)2SO4 and NH4Cl are mainly crystallized salts during the cooling process.The final(NH4)2SO4 and NH4Cl precipitation rates were 76.32% and 54.59% respectively.There may be a small amound of carnallite precipitation during the cooling process.


ABSTRACT The production of toxin (Apx)-neutralizing antibodies during infection plays a major role in the induction of protective immunity toActinobacillus pleuropneumoniae reinfection. In the present study, the gene encoding the ApxII-activating protein,apxIIC, was insertionally inactivated on the chromosome of a serovar 7 strain, HS93. Expression of the structural toxin, ApxIIA, and of the two genes required for its secretion, apxIB andapxID, still occurs in this strain. The resulting mutant strain, HS93C− Ampr, was found to secrete the unactivated toxin. Pigs vaccinated with live HS93C−Ampr via the intranasal route were protected against a cross-serovar challenge with a virulent serovar 1 strain ofA. pleuropneumoniae. This is the first reported vaccine strain of A. pleuropneumoniae which can be delivered live to pigs and offers cross-serovar protection against porcine pleuropneumonia.


This paper first discusses the right of being exempt from the liability of words in procedures. Then it discussed its theoretical foundation through analysis of the difference of legal world and real world. and of the mechanism through which the justice releases social resentment. Finally, its limitations are discussed. It's argued that words in procedure are exempt from liability on the condition that the words must be relevant to the certain cases and accord with the legal process.


Given that the quality control of asphalt mixture is crucial to the whole process of asphalt pavement construction,the discussion on quality control was carried out theoretically in three phases,including the preparation, mixing and afterwards.It is considered that the three phases commonly influence the construction quality of asphalt pavement.


it's this war that's raging off on the horizon my heart the war that's singing missiles of love across the wire the war that's wandering into my kitchen into the bath the news of the world the songs of the dead friends the great hope oflaughter as I step up into the light on the red red plain and wonder at the beauty ofspinifex off to the sky This journal article is available in Law Text Culture: http://ro.uow.edu.au/ltc/vol4/iss2/11


[11C](+)McN-5652 is an established positron emission tomography tracer used to assess serotonergic transporter density. Several methods have been used to analyze [11C](+)McN-5652 data; however, no evaluation of candidate methods has been published in detail yet. In this study, compartmental modeling using a one-tissue compartment model (K1, k″2), a two-tissue compartment model (K1 to k4), and a noncompartmental method that relies on a reference region devoid of specific binding sites were assessed. Because of its low density of serotonergic transporters, white matter was chosen as reference. Parameters related to transporter density were the total distribution volume DV″ (=K1/k″2, one tissue compartment), DVtot (=K1/k′1 (1 + k3/k4), two tissue compartments), and Rv (=k′3/k4, noncompartmental method). The DV″, DVtot, and Rv values extended over a similar range and reflected the known pattern of serotonergic transporters. However, all parameters related to transporter density were markedly confounded by nonspecific binding. With regard to K1, the one-tissue compartment model yielded markedly lower values, which were, however, more stable. The minimal study duration needed to determine stable values for the distribution volume was ∼60 minutes. The choice of the method to analyze [11C](+)McN-5652 data depends on the situation. Parametric maps of Rv are useful if no information on K1 is needed. If compartmental modeling is chosen, both the one- and the two-tissue compartment models have advantages. The one-tissue compartment model underestimates K1 but yields more robust values. The distribution volumes calculated with both models contain a similar amount of information. None of the parameters reflected serotonergic transporter density in a true quantitative manner, as all were confounded by nonspecific binding.