In the year 1911 the heading "Status Lymphaticus" was first used in the publications of the Registrar-General of England and Wales and, in that year, 121 deaths were assigned primarily to this heading; Status Lymphaticus was also mentioned in the certificates relating to 25 of the deaths which occurred under anaesthesia. The heading was retained in the published tabulations as first introduced until 1921, when certifications of Status Lymphaticus were classified under the heading of "Diseases of the Thymus," of which statistical group they have, so far, formed the whole. Between 1911 and 1924 (inclusive) the annual deaths—inclusive of those associated with anaesthesia—have fluctuated between 145 and 273. In the last four years there has been little variation, 209 in 1921, 204 in 1922, 200 in 1923 and 199 in 1924. Most of the deaths are in the age group 0–5 and a considerable majority are of males. Thus in the last two available years, 1923 and 1924, of 399 deaths 289 were at ages 0–5 and 258 were of males (respectively 72 and 65 per cent.). If the 85 deaths in which anaesthesia was an associated condition are excluded, 81 per cent. are of children aged 0–5 and 64 per cent. of males (Table I).


A new approach based on plate laminate theory (PLT) is developed to calculate the mechanical properties of woven and braided composites. It supposes that, for each woven or braided composite oriented at ±θ, there is an equivalent ±θ angle-ply laminate made out of two unidirectional plies. An inverse algorithm based on PLT was developed to calculate, from the known mechanical characteristics of a composite reinforced by engineering fabrics, the properties of the mechanically equivalent angle-plies. The virtual angle-ply and cross-ply laminates obtained by inverse calculation include the effects of undulation and strand shear. The difference in properties between experience and theory is clear, especially for Poisson's ratio. Comparisons performed between numerical predictions and experimental tests have shown a good correlation.


Copyright: © 2015 Tales A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Andrea Tales, Ph.D, MSc [Oxon], BSc Hons, Chair in Dementia Research, Department of Psychology and College of Human and Health Sciences, Swansea University, Swansea, Wales, UK, E-mail: firstname.lastname@example.com


analytic function regular in the vicinity of the origin, by the series of the form above stated, where f(z) is a polynomial or an entire function, such that f(0)=0, f'(0)=l. Suggested by this paper, I have obtained a very simple proof for Widder's theorem on the expansion of an analytic function in generalized Taylor's series. This theorem may, somewhat modified from its original form, be stated as followsTheorem. Let P(z) be the functions satisfying the following conditions in the domain zl__R (1) P(z) are regular analytic in zlR; (2) P,(z)= 1 + h,(z) where h,(z) b')z + b')zfor z R, (n= 0, 1, 2, ) (3) h(z) M for n+l Then any analytic function f(z), regular in z P R, can be expanded in one and only one way into a series of the form J a,zP,(z), convergent in z] <. Moreover, the coefficients a. are determined by the formula a=(-1)"


Migration reshapes rural economies in ways that may go beyond the contribution of migrant remittances to household income. Consumption and investment expenditures by migrant-sending households may transmit some of the impacts of migration to others inside and outside the rural economy, and they also may shape the potential effects of migration within the source household. Numerous studies have attempted to quantify the impact of migrant remittances on expenditures in migrant-sending households following one of two approaches. The first asks how migrant remittances are spent. It has the advantage of being simple but the significant disadvantage of ignoring the fungibility of income from migrant and nonmigrant sources. Remittances almost certainly have indirect effects on expenditures by way of their contribution to households' total budgets. The second uses a regression approach that considers remittances as an explanatory variable, in addition to total income and other controls, in a household expenditure demand system. It has the advantage of enabling one to test whether remittances affect expenditures in ways that are independent of their contribution to total income. But it does not take into account other ways, besides remittances, in which migration may influence expenditure patterns in households with migrants. It also may suffer from econometric bias resulting from the endogeneity of migration and remittance receipts. The same variables may simultaneously affect both remittances and household expenditures, and unless one controls for this, biased estimates may result.


Recently, a highly credible report suggested that the quality philosophy and quality standards have not effectively reached the core of Australia's commercial base – 780,000 small and medium enterprises (SMEs). Drawing on this critical finding, this study aims at providing empirical evidence on the differences in total quality management (TQM) implementation and organisational performance of SMEs in Western Australia, with and without ISO 9000 certification. Using the criteria of the Australian Business Excellence (ABE) framework as a guide, a questionnaire with 36 items was developed, checked for reliability and validity and applied to create a self‐assessment measure of TQM practices. The results showed that there was no significant difference between SMEs with and without ISO 9000 certification with respect to TQM implementation and organisational performance. This result concurs with the findings of studies conducted in the context of large organisations in Australia.


Segmentation is one of the most important tasks in preprocessing audio recordings for species recognition. For examples, bird songs or calls often consist of distinct short utterances. Correctly segmenting such utterances is an essential step in the analysis of bird songs or calls. Energy based time-domain segmentation is commonly used and can be fairly effective when dealing with high signal-to-noise ratio recordings of a single individual. We consider the scenario in which omnidirectional microphone are deployed for round-the-clock in-situ species monitoring. In such scenario, recordings may suffer from two problems: (i) low signal-to-noise ratio and (ii) simultaneous vocalizations of multiple individuals. We are interested in segmentation of such recordings. We propose a framework for supervised time-frequency segmentation of audio recordings. Using manually labeled spectrograms, a classifier is trained to separate vocalization from the background noise in the two dimensional time-frequency domain.


BACKGROUND
Partial GH deficiency (GHD) in adults is poorly studied.

OBJECTIVE
The objective of the study was to investigate the natural history and clinical implications of partial GHD.

STUDY DESIGN
This was an analytical, observational, prospective, case-control study.

PATIENTS
Twenty-seven hypopituitary patients (15 women, ages 20-60 yr) and 27 controls participated in the study.

MAIN OUTCOME MEASURES
Measures included GH peak after GHRH plus arginine [(GHRH+ARG), measured by immunoradiometric assay]; IGF-I (measured after ethanol extraction) z-sd score (SDS); glucose, insulin, total cholesterol, high-density lipoprotein (HDL) cholesterol, and triglyceride levels; and common carotid arteries intima-media thickness (IMT) measured periodically.

RESULTS
At study entry, partial GHD patients had significantly lower IGF-I and HDL-cholesterol levels and homeostasis model assessment index than controls. During the 60 months of median follow-up, 11 patients had severe GHD (40.7%), seven normalized their GH response (25.9%), and nine showed persistently partial GHD (33.3%). Patients with developed severe GHD at baseline had similar age and body mass index and lower GH peak (11.5 +/- 1.8 vs. 14.3 +/- 1.5 and 12.8 +/- 1.1 microg/liter, P = 0.008) and IGF-I SDS (-0.88 +/- 0.48 vs. 0.15 +/- 0.58 and -0.42 +/- 0.78; P = 0.01) than the patients with normal GH secretion or partial GHD. Severe GHD was accompanied by decreased IGF-I SDS and increased total to HDL cholesterol ratio, triglycerides, homeostasis model assessment index, and carotid intima-media thickness; normalization of GH secretion was accompanied by increased IGF-I SDS. By receiving-operator characteristic analysis, predictors of severe GHD were a baseline GH peak after GHRH+ARG of 11.5 microg/liter (sensitivity 64%, specificity 94%) and a baseline IGF-I SDS of -0.28 (sensitivity 91%, specificity 63%).

CONCLUSIONS
Of 27 patients with partial GHD after pituitary surgery, 40.7% developed severe GHD and 25.9% normalized their GH response. With the assay used, changes in the GH peak response to GHRH+ARG were accompanied by changes in the IGF-I SDS, metabolic profile, and carotid IMT. A peak GH of 11.5 microg/liter or less and IGF-I SDS -0.28 or less were highly predictive of delayed deterioration of GH secretion.


The title complex, [NiCl(C12H16N3O2)2(H2O)]NO3·2CH4O·H2O, was obtained from a methanolic solution of Ni(NO3)2·6H2O, 2-pyridyl nitronyl nitroxide (2-NITpy) and (NEt4)2[CoCl4]. The equatorial coordination sites of the octahedral NiII centre are occupied by two chelating radical ligands, with the axial positions occupied by the Cl− and water ligands. The H2O—Ni—Cl axis of the complex lies along a crystallographic twofold axis, so that only half the cation is present in the asymmetric unit. The Ni—Cl bond length [2.3614 (17) A] is significantly shorter than distances typical of octahedral NiII centres [2.441 (5) A]. However, with only one nitrate anion per formula unit, the oxidation state of the metal must be assigned as NiII. The 2-NITpy ligands bend away from the equatorial plane, forming a hydrophobic region around the Cl atoms. Conversely, the ligated water molecule forms moderately strong hydrogen bonds with the disordered methanol solvent molecules, which in turn form interactions with the water of crystallization and the disordered nitrate anion. These interactions combine to give hydrophilic regions throughout the crystal structure.


Irradiation (290 nm) of (Ia) in benzene produces the stereoisomers (IIa)-(IVa); pure (IIIa) and enriched (IIa) can be isolated by HPLC.


In an ionic crystal, the outer electrons from the negative ions will be shared to some extent with the surrounding metal ions. Allowing for this possibility in constructing approximate solutions of Fock's equations for the valence electrons, it is shown that the expression for the lattice energy contains an extra negative term representing the homopolar contribution. Numerical calculations are made for LiF and it is found that the homopolar contribution is only about 0.1% of the lattice energy. It is also shown that, whilst homopolar effects provide an additional source of attraction between nearest (unlike) neighbours, they enhance the repulsion between like neighbours.


The main problem with Monte Carlo methods is the vast model space needed to insure that it contains a satisfying solution to the special problem. An approach to overcome this is to constrain a large model space probabilistically. In the last ten years there has been an explosion of papers on Markov chain Monte Carlo in statistics (see the special issue of Journal of the Royal Statistical Society, B, 55, Vol 1, 1993) as well as in physical sciences. One reason for this is that the use of Markov chain Monte Carlo makes it possible to couple a user defined estimate with the Metropolis algorithm which can be used for optimization (Metropolis et al. (1953)). At the same time the mathematical properties make the algorithms analyzable by statistical tools. Mosegaard and Tarantola (1995) introduced these ideas to geophysics, but in an unacceptable mathematical framework (Houlder, 1996).


This paper proposes a new type of dual-band patch antenna that employs a metamaterial transmission line and two coupled microstrip lines. An equivalent circuit model is presented and analyzed by using multi-conductor transmission line theory. An open ended design is presented for which the radiation pattern of the antenna is omnidirectional/unidirectional in the first and the second frequency bands, respectively.


Let N be the set of nonnegative integers and let  be the weak direct product of  with itself. Mostowski[9] shows that the theory of  is decidable, but his decision procedure isn't elementary recursive. We present here a more efficient procedure which operates within space [equation]
 As corollaries we obtain the same upper bound for the theory of finite abelian groups, the theory of finitely generated abelian groups, and the theory of the structure  of positive integers under multiplication. Fischer and Rabin have shown that the theory of  requires time @@@@ on nondeterministic Turing machines [5].
 We also obtain some very general results about the nature of the theory of the weak direct product of a structure with itself.


Received -; accepted - Abstract. We present the redshift evolution of the restframe galaxy luminosity function (LF) in the red r', i', and z' bands as derived from the FORS Deep Field (FDF), thus extending the results published in Gabasch et al. (2004a) to longer wavelengths. Using the deep and homogeneous I-band selected dataset of the FDF we are able to follow the red LFs over the redshift range 0.5 < z < 3.5. The results are based on photometric redshifts for 5558 galaxies derived from the photometry in 9 filters achieving an accuracy ofz/(zspec + 1) ≤ 0.03 with only ∼ 1% outliers. A comparison with results from the literature shows the reliability of the derived LFs. Because of the depth of the FDF we can give relatively tight constraints on the faint-end slopeof the LF: The faint-end of the red LFs does not show a large redshift evolution and is compatible within 1� to 2� with a constant slope over the redshift range 0.5 ∼ < z ∼ < 2.0. Moreover, the slopes in r', i', and z' are very similar with a best fitting value of � = −1.33 ± 0.03 for the combined bands. There is a clear trend ofto steepen with increasing wavelength: �UV &u' = −1.07 ± 0.04 → �g'&B = −1.25 ± 0.03 → �r'&i'&z' = −1.33 ± 0.03. We subdivide our galaxy sample into four SED types and determine the contribution of a typical SED type to the overall LF. We show that the wavelength dependence of the LF slope can be explained by the relative contribution of different SED-type LFs to the overall LF, as different SED types dominate the LF in the blue and red bands. Furthermore we also derive and analyze the luminosity density evolution of the different SED types up to z ∼ 2. We investigate the evolution of Mand � � by means of the redshift parametrization M � (z) = M �


It remains very little until the complete destruction of the Earth. Man, like an unreasonable child, without knowing danger, destroys his cradle. Every living creature, every blade of grass on the planet has its purpose. Their origin, existence and reproduction depend on water. Water is the working body, is in a continuous cycle of transformations. Advancing it along bodies, trunks and stems is an integral part of the overall hydrological cycle. The balance of these transformations was created for millions of years. There is evidence that every hectare of land contains 20 tons of living organisms, each of which converts water.


Spreading every transmitted bit over each sub-band and interleaving the spread signals over all of the sub-bands would provide the robustness to narrow-band interference in the ultra-wide band (UWB) system based on orthogonal frequency-division multiplexing (OFDM). Simulation results show that the system has evident robustness against narrow-band interference and would improve the performance about 5dB in SIR or 1-2 order in BER.


Reissued in the VIRAGO MODERN CLASSICS series, a novel about a painter who specialises in copying other's work. Troubled by his artistic conscience and the women in his life, he eventually draws a remarkable conclusion from his work and the silent agony of his son. From the author of GEORGE BENEATH A PAPER MOON.


The myelodysplastic syndromes (MDS) are a very heterogeneous group of clonal disorders, characterized by cytopenia in peripheral blood and a higher risk of becoming acute myeloid leukemia.Today, clinical treatment is focused on the risk classification using the Revised International Prognostic Scoring System (IPSS-R). The 5-azacytidine treatment is one of the pillars for high risk patients, and sometimes for low risk as well. In order to assess their response, the International Working Group 2006 (IWG 2006) criteria are used. Material and methods. A cross-section descriptive analytical study was carried out from June 2016 to May 2018 in the Hematology Service at Nestor Kirchner Hospital in Tucuman, Argentina. All patients with MDS diagnose (N=22) were included. Response was evaluated in those patients receiving 5-azacytidine according to the IWG 2006 criteria. Results and conclusions. The prevailing age group was over 60 years old, with a slight male prevalence. Most of the patients were of a very low IPSS-R risk and they had a standard karyotype. Half of them received a 5-azacytidine treatment, and from them, 4 patients had a complete remission, 2 stable disease, 1 hematology improvement and 4 failure. These data are in accordance with reports provided by national and int rnational bibliography. Results intend to become a statistical reference. The main limitation was the number of evaluated individuals. The possibility to carry out studies under a cooperation agreement among institutions and national groups will make possible to solve the number of analyzed patients.


I n 1988, a total of 721 road users were killed in New Zealand, and 17,317injured. The cost to the country of all road accidents, based on figures supplied by the Ministry of Transport, is estimated to be a staggering $600 million (U.S. dollars) a year.' When compared with two developing countries, one of which had high vehicle ownership comparable to New Zealand, New Zealand had a higher fatality rate.' However, the actual problem is even greater than the statistics show. While accidents involving deaths are fully reported, other accidents are not. Research showed that injuries to car occupants were likely to be underreported by about 14 percent, by 27 percent by pedestrians and by 60 percent by pedal cyclists. ~ This article looks at the main components of accidents in New Zealand that contribute to the overall number of accidents, compares road safety parameters with other countries and explores strategies to improve safety performance on New Zealand roads.


The 2-DOF(degree of freedom) linkage mechanism system is investigated.Based on the air-gap field of non-uniform airspace of motor caused by the eccentricity of rotor,the electromechanical coupling relation in the real running state of motor is analyzed.And the electromechanical coupling dynamic model of the system is established by the finite element method.The dynamic equation is the bases on which the primary resonance properties of the system caused by electromagnetic parametric excitation of the servomotor are analyzed by the multiple scales method.The first-order stationary solution is obtained under that condition.The characteristics of primary resonance of the system are disclosed.


In this paper, detailed static characterization of the new 650 V/ 30 A GaN device from GaN Systems is presented. The on-resistance and output capacitance of this device are considerably low making GaN a viable option for high switching frequency (in the range of MHz) medium power applications (> 3 kW). A comprehensive examination of device characteristics and variation of device parasitics depending on operating conditions is presented. Due to the high slew rate of these devices, it is important to incorporate galvanic isolation between gate driver input and output stage as recommended in GaN Systems' application note[1]. Also, the gate loop and power loop stray inductances and capacitances need to be minimized to curtail the switching noise. To achieve this, vertical power loop design with very small parasitic inductance is proposed. The dynamic characterization carried with this design shows reduction of voltage overshoot to less than half compared to the lateral power loop design from [1].


Abstract Mongolia is undergoing rapid economic, social and political change. A key question facing the government is how it will manage this rapid change to ensure opportunities are shared among its citizens. This article reports on the findings from a household survey of 80 newly arrived residents in the fringe areas of the capital city. The paper concludes that existing government policy is not addressing the social exclusion of these residents. The social work profession is poorly placed to contribute to the needed policy changes. Significant investment in community capacity building is required to enable resident participation and inclusion.


The purpose behind this work is to produce polystyrene-divinylbenzene cation exchange resin particles at
various sizes, smaller than are conventionally available, and to use them in a microfiltration process;
comparing the results with conventional column operation. As a model system, for production of droplets
using membrane emulsification, sunflower oil (discontinuous phase) and 2% Tween 20 solution (continuous
phase) were used. By increasing the shear at the membrane surface the droplet size decreased from 185 to
50 μm. In the seeded microfiltration process, surface microfilters with slots without internal tortuosity were
used to minimize fouling. A filtration flux rate of 3432 l m-2 h-1 was achieved. Rates of copper sorption on to
ion exchange resin were found to be dependent on mass transport limitations due to aqueous film diffusion
and internal particle diffusion. For prediction of copper sorption a model that takes into account both film and
internal diffusion was used. Microfiltration combined with ion exchange has the advantage of very fast
kinetics, when compared to column use, and may provide better utilization of the resin particle, depending on
the internal diffusion coefficient of the transferring species within the particle.


Clark, in his studies of the apple with the hat-pin, found that children of 6 years and under demanded that the total part of the pin show all the way through the apple as the pin did go through it; it was not two pieces of pin sticking into the apple but a whole pin going through the apple. Above 9 years and even beginning at 8 the children were more given to realistic representation (2). Rouma found the same obstinacy on the part of this younger group to portray what they knew to be there; he says that when he would stop them and ask them to look at the object they seemed to be annoyed and would only give it the required observation or glance and then continue drawing the


Education has always been considered an area of national sensitivity and that for a number of reasons. These range from the obligation of the state to provide compulsory education, to the role of educational institutions as nationally embedded socialising institutions. Yet, despite the tenuous nature of the legal basis that gives some substance to policy-making at Community level, the Commission is taking on an increasing role in education, and particularly in higher education.


Objective To review the method of removing double J stent in females with nucleus gelatinosus clamp guided by ultrasonic and evaluate its clinical effect.Methods Guided by the ultrasound ,we use nucleus gelatinosus clamp to remove 80 patients' 85 double J stents in females.Results Of all the cases,the double J stents were removed successfully,the operation time ranged from 1 to 3minutes,with no injury mucous membrane of urinary bladder,no haematuria and urinary tract infection.Conclusion The method of removing double J stent in females with nucleus gelatinosus clamp guided by ultrasonic is convenient,safety and effective,and deserved to be spread.


and The Song of the Chant. Now she has given us a book in which Gregorian Chant is analyzed and studied in the same manner in which she has presented it to her classes during the past three decades. Judging by the book, she has been a most successful teacher. Pope Pius X imposed upon the people anew the obligation of singing the Ordinary of the Mass : Kyrie, Gloria, Credo, Sanctus, and the Agnus Dei. Marie Pierik has spent a life time doing her share of labor in trying to bring this wish of the Holy Father into reality. Here she has produced a textbook in which the art of interpreting chant has not assumed theoretical airs of a complicated and intricate nature. The work opens with a brief prologue highlighting Jesus as the first Christian Cantor. Then in the first three chapters are found a history of Gregorian Chant, of the Proper of the Mass, and of the Ordinary. Chapter the Fourth describes and illustrates the neums, gives the pronunciation of Liturgical Latin, outlines a few breathing and vocal exercises, and analyzes the relation of rhythm and interpretation of the verbal and musical text. To illustrate perfectly what she means in a practical way, she closes her work with an analysis of a complete Ordinary with chironomic drawings. This work is recommended to all musicians and to priests who may be encouraged to start congregational singing through this review of the rules on Chant. A.G.


AIMS
Women and men suffering of coronary artery disease differ in their risk profile. We sought to investigate the impact of sex on 2-year outcomes after BVS implantation in routine clinical practice.

METHODS AND RESULTS
Sex-based analysis of clinical outcomes was done by pooling the individual patient data of ISAR-ABSORB and KUM-ABSORB registries performed in 4 high-volume tertiary centers in Munich. Of the total of 1032 patients, 259 (25.1%) were women. The primary composite endpoint of death, target-vessel myocardial infarction (TV-MI) and target lesion revascularization (TLR) through 2 years occurred in 13.2% of women and 17.9% of men (p = 0.12). Compared to men, women experienced numerically lower rates of TLR and definite or probable BVS thrombosis - 7.5% vs. 12.4% (p=0.051) and 1.2% and 2.7% (p=0.20), respectively. Independent predictors of increased risk for TLR were use of smaller size BVS (HR 1.28, 95% CI 1.02-1.62), while being women was a protective factor (HR 0.59, 95% CI 0.35-1.00).

CONCLUSIONS
BVS used in routine setting tends to perform better among women compared to men, which might be partially related to their lower complexity of coronary artery disease.


This paper examines income instability of lone parents, singles and two-parent families in Canada in the past two decades using tax data. We attempt to answer the following questions: Has there been a widespread increase in earnings instability among lone parents (especially lone mothers) and unattached individuals over the past 20 years? How do the trends in earnings instability among lone parents and unattached individuals compare to the trends among the two-parent families? What is the role of government transfers and the progressive tax system in mitigating differences in earnings instability across different segments of the earnings distribution among the above-mentioned groups? We find little evidence of a widespread increase in earnings instability in the past two decades and show that government transfers play a particularly important role in reducing employment income instability of lone mothers and unattached individuals.


the symposium affirmed that it was an exciting session. Unfortunately, little of this has been captured in this publication. The book lacks a coherent point of view on a clearly delineated topic. Chapters range widely across time (from the 1500s to the present), space (from Siberia to the U.S. Pacific Northwest, from Hawaii to Malaysia), and theme (international trade in forest products, institutional dimensions of forest management, exploitation of non-timber forest products by indigenous peoples). The editors have made no effort to show the reader how the diverse chapters may cohere to provide a broader historical understanding of the forest economy of the Asia-Pacific region. Their two-and-a-half-page "introduction" hardly merits its title. Some individual chapters are quite interesting: N. Mengies's reconstruction of logging cycles in China's Shaanxi Province in the late Imperial Period sheds new light on the contentious issue of environmental degradation by precapitalist social formations. Unfortunately, the chapter's title is seriously inflated, leading the reader to expect that it offers a comprehensive account of the premodern history of forest exploitation in China as a whole, rather than being limited to describing what happened over the past 300 years in one small area. The same charge can be made with regard to the book's title, which suggests a far more ambitious enterprise than is actually found within the covers of this slim volume. Lim Hin Fui provides useful recent statistics on trade in non-timber forest products by Malaysian aborigines but fails to offer any advance in overall understanding of the nature of this resource exploitation system beyond that achieved by F. L. Dunn in his classic study published twenty years ago. R. Tucker's account of the Philippine Bureau of Forestry's attempts to deal with noncommercial users of forests reveals the deep roots of professional foresters' still-persisting prejudice against swidden agriculture. K. E. Jackson's rather dense account of New Zealand's forest policies and trade raises interesting questions about the possibilities of controlling deforestation on an expanding agricultural frontier, questions that he then applies to the current situation in the Amazon. Chapters by G. Henning, T. Waggener and C. Backman, and H. Kakizawa present useful insights into the impacts of Japan's demand for timber on forest management in the Pacific Northwest and the former Soviet Far East.


Background: The control of organ growth is critical for correct animal development. From flies to mammals, the mechanisms regulating growth are conserved and the role of microRNAs in this process is emerging. The conserved miR‐7 has been described to control several aspects of development. Results: Here, we have analyzed the function of miR‐7 during Drosophila wing development. We found that loss of miR‐7 function results in a reduction of wing size and produces wing cells that are smaller than wild type cells. We also found that loss of miR‐7 function interferes with the cell cycle by affecting the G1 to S phase transition. Further, we present evidence that miR‐7 is expressed in the wing imaginal discs and that the inactivation of miR‐7 increases the expression of Cut and Senseless proteins in wing discs. Finally, our results show that the simultaneous inactivation of miR‐7 and either cut, Notch, or dacapo rescues miR‐7 loss of function wing size reduction phenotype. Conclusions: The results from this work reveal, for the first time, that miR‐7 functions to regulate Drosophila wing growth by controlling cell cycle phasing and cell mass through its regulation of the expression of dacapo and the Notch signaling pathway. Developmental Dynamics 244:21–30, 2015. © 2014 Wiley Periodicals, Inc.


We introduced seismic design of a base isolated building in the proximity of a hypothetical M8 earthquake. Our seismic design is based on the assumption that an M8 Tokai earthquake will occur in the vicinity of the site in near future. In order to evaluate the regional ground properties, we performed the microtremor array survey (Yamanaka, 1995) and ground motion observation at and around the construction site. Based on the survey and observations, and comparing the advantages and disadvantages of the strong motion prediction methods available, the following evaluations were performed; 1. Empirical method (Kobayashi and Midorikawa, 1982). 2. Semiempirical method (Irikura, 1986). 3. Theoretical method (Hisada, 2000). The maximum amplitudes of the seismic wave calculated using the three methods are as follows; Empirical method: 498cm/sec, 36cm/sec, 13cm. Semi-empirical method: 350cm/sec, 25cm/sec, 16cm. Teoretical method: 542cm/sec, 80cm/sec, 56cm. Because of directivity effect, near source long period pulses are generated using the theoretical method. As a result, theoretical results are larger than another two. Satisfaction of the acceptability criteria was confirmed by conducting dynamic response analyses using the ground motion for aseismic design. The result of the response analysis, which was conducted under the worst scenario of theoretical method, revealed that the maximum shear coefficient of upper structure and the maximum deformation of seismic isolation interface are 0.202 and 44.6cm, respectively. It has been judged that the results could satisfy our acceptability criteria (0.205 and 50cm).


Atherosclerotic patients challenge the anesthesiologist as they display a significant instability between the two parts of the autonomic nervous system. We aimed to assess the effect of general anesthesia (GA) and surgery on serum cholinesterase activity. Prospective study of 57 patients undergoing ambulatory or vascular surgery under GA. Cholinesterase levels were measured before induction of anesthesia, 15 minutes thereafter and at the end of surgery by measuring the capacity of serum Acetylcholinesterase (AChE) and Butyrylcholinesterase to hydrolyze AcetylThioCholine. Data of atherosclerotic disease, anesthesia management were analyzed.Both AChE and total Cholinergic Status (CS) decreased significantly after GA induction at 15 minutes and furthermore by the end of surgery. Vascular surgery patients, presented lower baseline cholinesterase activity compared to patients for ambulatory surgery. In patients requiring intraoperative administration of phenylephrine for hemodynamic support (21.1%), a significant lower level of AChE and CS was observed compared to untreated patients. A positive correlation was found between the lowest temperatures measured and the AChE and CS change from the baseline values. Our findings serve as a mirror to the sympathetic/parasympathetic disbalance during GA with a marked decrease in the parasympathetic tone. Our data show that low cholinesterase activity increase the need for hemodynamic support.


Cucumber, Cucumis sativus L. is an important vegetable crop worldwide. Among the ~66 species in the genus Cucumis, cucumber is the only one with 2n = 2x = 14 chromosomes. The rest, including its sister species, C. hystrix, have 2n = 2x = 24 chromosomes or multiples of 12 chromosomes. Cucumber evolved from its extinct 2n = 24 ancestor through dysploid chromosome reduction, in which many chromosome rearrangement events (inversions, fusions, and translocations) were involved with the exception of cucumber Chromosome 7, which remained largely intact during the entire evolution of Cucumis. There are four cross‐compatible botanical varieties in C. sativus, including the wild cucumber (C. s. var. hardwickii), the semi‐wild Xishuangbanna cucumber (C. s. var. xishuangbannesis), the Sikkim cucumber (C.s. var. sikkimensis), and the cultivated cucumber (C.s. var. sativus). The wild cucumber is the progenitor of cultivated cucumber, but differentiated from the other three taxa in the amount and distribution of heterochromatin, as well as several large inversions. Cucumber has been cultivated in India for at least 3,000 years. It spread eastward to China and westward to Europe around 2,000, and 700–1500 years ago, respectively. 4


It is clear from the foregoing considerations that the development and secretory activity of the sebaceous gland of man is influenced by hormonal factors. Androgenic steroids, particularly of gonadal origin, are the hormones principally responsible for these effects and the only ones shown to have a direct stimulatory effect on glandular activity. Adrenal androgens may be responsible for early sebaceous gland maturation in late childhood, at a time when minor degrees of acne sometimes occur. Glucocorticoids appear to function in a permissive capacity, the anterior pituitary hormones primarily affecting the sebaceous gland indirectly through stimulation of their respective target organs, i.e., the gonads and the adrenal gland. The role of the thyroid and other endocrine glands is unknown and needs to be studied.


The combined heating with fan-coil and floor radiation is introduced in this paper.A reconstruction project is simulated by the software AIRPAK and verified by experiment.The agreement between the simulation and the experimental result is proved that well comfort and energy-saving effect can be achieved with this system and the software AIRPAK can be used to practical engineering design.The temperature distribution of floor and space with local floor radiation heating is also presented in this paper.


The state of the art in selected composite material of rotor blade in domestic and foreign is reviewed in according to our experience in composite blade design and analysis for many years, especially for some problem about applied composite material of blade in domestic, and some viewpoint of development in the future is presented.


A British anaesthetist who reinvented himself as a minimally invasive spinal surgeon in the United States after his 2001 conviction in the United Kingdom for gross negligence manslaughter has had his licence to practise in New Jersey revoked for posing a danger to the public.

Richard Kaul has been stripped of his licence by the state board of medical examiners and ordered to pay $300 000 (£179 000; €219 000) in civil penalties …


Abstract The Maier-Saupe theory1 of the order-disorder transition in nematogens has been extended to allow for a rigorously correct form of the anisotropic intermolecular potential.2 The potential energy of one rod-like molecule in the field generated via the interaction with its neighbours is found to be


The high unemployment rate is a fundamental problem in employment in our country, where the new workforce that is added is far greater than the increase in employment. Unemployment is a problem for countries with high population growth rates, and unemployment can also affect the level of the economy. At the beginning of 2020, world economic growth experienced a decline due to the coronavirus disease outbreak, this coronavirus (covid-19) had an impact on economic growth in the form of a decline in the level of the world economy, including Indonesia. Seeing conditions like this, special attention is needed for alumni to prepare students for the world of work. This community service is carried out in the form of training on strategies for finding and applying for jobs, the problem solving framework provided is by providing training so that it can increase knowledge and insight to job seekers college alumni about srategies for finding and applying for jobs.The purpose of this community service activity is to provide training to college alumni so that they have the readiness to find and apply for jobs. This community service activity is carried out virtually online online in the form of training and guidance. The target is college alumni who will definitely be involved in the activity of finding and applying for jobs, at the initial stage the presenter will deliver a theoretical presentation accompanied by realistic examples. The results of the implementation of community service by providing the training are expected that college alumni as prospective job seekers already have the knowledge, insight and readiness in finding and applying for jobs, then to provide knowledge and insight about strategies for finding and applying for these jobs, as well as the factors that must be considered.The high unemployment rate is a fundamental problem in employment in our country, where the new workforce that is added is far greater than the increase in employment. Unemployment is a problem for countries with high population growth rates, and unemployment can also affect the level of the economy. At the beginning of 2020, world economic growth experienced a decline due to the coronavirus disease outbreak, this coronavirus (covid-19) had an impact on economic growth in the form of a decline in the level of the world economy, including Indonesia. Seeing conditions like this, special attention is needed for alumni to prepare students for the world of work. This community service is carried out in the form of training on strategies for finding and applying for jobs, the problem solving framework provided is by providing training so that it can increase knowledge and insight to job seekers college alumni about srategies for finding and applying for jobs.The purpose of this community service activity is to provide training to college alumni so that they have the readiness to find and apply for jobs.This community service activity is carried out virtually online online in the form of training and guidance. The target is college alumni who will definitely be involved in the activity of finding and applying for jobs, at the initial stage the presenter will deliver a theoretical presentation accompanied by realistic examples. The results of the implementation of community service by providing the training are expected that college alumni as prospective job seekers already have the knowledge, insight and readiness in finding and applying for jobs, then to provide knowledge and insight about strategies for finding and applying for these jobs, as well as the factors that must be considered.


Correlated survival data with possible censoring are frequently encountered in survival analysis.When there are dependencies among observed survival times, conventional Cox proportionalhazards model (CPHM) and Accelerated Failure Time (AFT) models that assumes independentresponses may not be appropriate. In this study, we compare the performance of parametric andsemi-parametric survival models with application to clinical data. Specifically, the AFT modeland the CPHM with and without Random effect were compared. Data on hypertension wascollected from Federal Medical Centre Keffi and General Hospital Nasarawa for the period offive years (2016 – 2020). The results from the analysis revealed that the Weibull AFT modelwith Gamma Random effect distribution had the least AIC and BIC values indicating that itoutperformed the other models considered in this study. Hence, the interpretation of the resultswas based on the most efficient model. Based on our results, it was found that hypertensionpatient that were giving drugs on the visit to the hospital has longer survival time compared tothose that were not giving drugs. Also, Hypertension patient with blood group AB and Obesedhave lesser survival time as compared to those with blood group o+ and normal weightrespectively. The study recommend that health expert can use the Weibull AFT model withGamma Random effect for predicting the risk factors of Hypertension especially when the dataare correlated.Keywords: AFT, CPHM, Hazard, Hypertension, Survival,


In this paper, we focus on named entity boundary detection, which is to detect the start and end boundaries of an entity mention in text, without predicting its type. The detected entities are input to entity linking or fine-grained typing systems for semantic enrichment. We propose BdryBot, a recurrent neural network encoder-decoder framework with a pointer network to detect entity boundaries from a given sentence. The encoder considers both character-level representations and word-level embeddings to represent the input words. In this way, BdryBot does not require any hand-crafted features. Because of the pointer network, BdryBot overcomes the problem of variable size output vocabulary and the issue of sparse boundary tags. We conduct two sets of experiments, in-domain detection and cross-domain detection, on six datasets. Our results show that BdryBot achieves state-of-the-art performance against five baselines. In addition, our proposed approach can be further enhanced when incorporating contextualized language embeddings into token representations.


Objective
To analyse MMACHC mutations for 45 pedigrees with combined methylmalonic aciduria and homocyctinuria by Sanger sequencing, and to discuss the utility of prenatal genetic diagnosis for these pedigrees.

Method
Peripheral blood was collected from 45 probands and their parents from 2012-2015 in Genetic Counselling Clinic of the First Affiliated Hospital of Zhengzhou University, and the DNA were extracted from the blood. Then the coding sequence of MMACHC gene was amplified by PCR, and the PCR products were further sequenced to detect mutations for each pedigree. For 12 families, chorionic villus sampling was performed on the pregnant women to make prenatal genetic diagnosis.

Result
There were 14 distinct mutations detected in the 45 pedigrees, and the most frequent mutations are c. 609G>A(W203X), c.658-660delAAG(K220del)and c. 80A>G (Q27A). Two of those mutations have not been reported before: one is a splicing site mutation c. 81+ 1G>A; while the other is a missense mutation c. 665A>G, p.Y222C. Most mutations were found in exon 4.Among the 12 pedigrees who received prenatal diagnosis, 2 fetuses were normal, 7 fetuses were carriers of heterozygous mutation, and the other 3 fetuses were patients with compound heterozygous mutation or homozygous mutation. The couples whose fetuses were normal or carriers continued the gestation, while the couples whose fetuses were patients decided to terminate the pregnancy. After delivery, the outcome of the fetuses was the same as the prenatal diagnose results.

Conclusion
Two novel mutations of MMACHC were identified and prenatal genetic diagnosis helps to avoid the delivery of combined methylmalonic aciduria and homocyctinuria patients.(Chin J Lab Med, 2016, 39: 613-617)

Key words:
Amino acid metabolism, inborn errors; Homocystinuria; Carrier proteins; Mutation; Prenatal diagnosis


Pathogens are always a threat to the livestock and domestic animals due to their exposure to the contaminated environments. The study was conducted to evaluation of the prevalence of Escherichia coli, Shigella spp., Salmonella spp., and S. aureus, in farm animals (cattle and buffalos). A total of 150 (n = 150) samples were collected from cattle and buffaloes, 60 samples from cows' and buffalo's teats milk, 30 of water samples, and 60 of fecal samples isolates from dairy farm animals, which may act as reservoir disseminating such pathogens. Farm hygiene, management, and milking procedure were listed through a questionnaire. The most common pathogens detected in this study was E. coli 88 (58%) and S. aureus 81 (54%), followed by Salmonella spp. 32 (21%), and Shigella spp. 44 (29%), respectively. During the antibiogram studies, the results revealed that the highest number of bacterial isolates showed resistance against ampicillin 50 (56.8%), followed by ciprofloxacin 23 (26.1%) and augmentin 22 (25%) of Escherichia coli and ampicillin 49 (60.4%), cefpodoxime 23 (28.3%), and augmentin 20 (24.6%) of S. aureus. In the case of Salmonella spp., the highest resistance was showed by amoxicillin 16 (50%). In Shigella spp., the highest resistance was shown by ampicillin 16 (36.3%), followed by cefpodoxime and ceftazidime 10 (22.7%). The high frequency of isolates in this investigation with multiple antibiotic resistance ranges from 15. MARI % value of S. aureus and E. coli 15 (12.5%), followed by Salmonella and Shigella spp. ranges from 12 (10%), suggesting the presence of various antibiotic-resistant bacteria as well as highly resistant bacteria. The mean ± SD zone areas for the greater resistance are for E. coli and S. aureus, already known to be multiresistant, followed by Salmonella spp. and Shigella spp., when the zone areas are for the low resistance, and the findings determined that there was a little difference between S. aureus and E. coli.


In this paper, we demonstrate a simple facile aqueous chemical route to prepare large scale Gd doped ZnO nanorod at a temperature of 95°C. X-ray diffraction pattern confirms the wurtzite phase of Gd-doped ZnO nanorods having intense (002) peak with a peak shift towards lower angle. The UV emission intensity decreases by two orders of magnitude and blue-orange broad-band emission emanates from the defects, increases slightly by doping Gd ion in ZnO. Localized SAED patterns taken using nanoprobe size reveals that the nanorods are single crystals grown along c-axis [0001] direction. A systematic evalution of enhancement in ferromagnetism (M = 0.07 × 10-2 emu/g to 1.4 × 10-2 emu/g) indicates incorporation of Gd ions into the Zn lattice sites.


INTRODUCTIONFuelled by political struggles, as well by philosophical and linguistic and other cross disciplines concerns, "identity" had emerged as the central theme of cultural studies during the 1990s and also formed a critical cornerstone within modem thought.Identity and subjectivity are closely connected and virtually inseparable, but not replaceable. They both exploring the assumptions of western "regime of the self', while subjectivity poses question about what a person is, identity is to inquire how we see ourselves and how others see us (Barker, 2003). In sum, identity is about sameness and difference, "about what you have in common with some people and what differentiates you from others (Weeks, 1990, p. 89)."However, overwhelmingly in recent years, the discussion of identity had reoriented from personal and social to political, especially from subjectivity constmction to the politics of particular cultural identities within specific historical conjunctures. The politics of cultural studies had playing an increasingly important role through debates around identity, rather than class or gender as used to be, especially since 1990s. For instance, Beverley Skeggs (1997) had ever focused on the "working class", pointing out that the disappearance of that class was actually a category of self-identification over that period. From this perspective, identity was retrieved as a thoroughly political category, or even directly equated to an exactly political artifact, in which direct engagement was worthwhile. Therefore, to some extent, the trend had been continually exaggerating and seems to be political-oriented, no wonder that Lawrence Grossberg expressing irritation at the "tendency to equate cultural studies with the theory and politics of identity and difference (Grossberg, 1996, p. 87)."Within this trend, identity was universally described as "contingent, fragile and incomplete" and "more amenable to reconstitution than was previously thought possible (du Gay, Jessica & Peter, 2000, p. 2)." In other words, identity is being constructed, and this is the so-called anti-essentialism.For the studies and debates in identity, the western search may be labeled with two dimensions: essentialism and anti-essentialism, one assumes an "essence" of the self we call identity, while the other argues that identity is discursive construction. Stuart Hall (1990) has usefully summarized the essentialist and anti-essentialist positions that in the essentialist version identity is regarded as the name for a "one true self', while in anti-essentialist position identity is regarded as a process of becoming rather than a reflection of a fixed, natural, state of being.While there is now agreement about anti-essentialism that identity is indeed culturally produced, there is not much agreement about how this process might work. Some great scholars' contribution for the explanatory role, But, just like Hall's (1996) review of these contenders, while each of these theories have their uses, none of them are sufficient by themselves, some more specific exploring bout the routes and process of the identity construction are needed. And, ritual is one of the possibilities.For the ritual studies, separation of sacred practices from customary activities has long been considered a key property of ritual, which may be employed to create and preserve collective identities. In order for groups to know themselves and others, they must "announce" their identities. They do this by engaging in social practices, especially in specific rituals, that highlight their symbolic place in the world. This process may be the so call identification process (Goffman, 1959, 1969; Lamont, 1992; McCall, 1978).But the preview studies about using rituals in identification are mostly focus on the collective level and even national level, it is surprising that so little research has actually been conducted on the individual level; therefore, what remains to be explored, is how a person highlights his or her personal political salience in ritual to create, preserve his political identity? …


Previous descriptions of the two species of the family Chappuisiidae are amcnded based on a close re‐examination using light and electron microscopy. These additions and corrections refer in particular to the antennae 1 and 2. the mouthparts. the male P5 and the genital fields of the females.


After some brief definitions, the paper deals with the influence of a regenerative air preheater on the performance of a simple open-cycle gas turbine, and formulas are given to show this influence, as well as the connection between the regenerator dimensions and the condition of minimum fuel consumption.


We advance the theory of aggregation operators and introduce non-monotone aggregation methods based on minimization of a penalty for inputs disagreements. The application in mind is processing data sets which may contain noisy values. Our aim is to filter out noise while at the same time preserve signs of unusual values. We review various methods of robust estimators of location, and then introduce a new estimator based on penalty minimisation.


Several authors [1, 5, 9] have investigated the algebraic and transcendental values of the Gaussian hypergeometric series (formula here) for rational parameters a, b, c and algebraic and rational values of z ∈ (0, 1). This led to several new identities such as (formula here) and (formula here) where Γ(x) denotes the gamma function. It was pointed out by the present authors [6] that these results, and others like it, could be derived simply by combining certain classical F transformation formulae with the singular values of the complete elliptic integral of the first kind K(k), where k denotes the modulus. Here, we pursue the methods used in [6] to produce further examples of the type (1·2) and (1·3). Thus, we find the following results: (formula here) The result (1·6) is of particular interest because the argument and value of the F function are both rational.


Purpose : Thanks to the growth of ICT, the traditional paper delivery order has been rapidly replaced by an electronic equivalent. In the MSC Eugenia (2017), the English Court had to consider whether...


In this study, four important techniques for estimating the non-process energy (heating, cooling, lighting and ventilation) in industrial and manufacturing buildings were examined. The building energy data for two industrial facilities were collected and analysed. The building non-process energy includes lighting, heating, cooling and ventilation. The power intensity (kW/m2) for each energy type use was estimated using two or more methods (direct measurement of non-process energy, direct measurement of process energy, regression and simulation) and then analysed. The results of these estimates were close to each other which indicate that any method can be used based on available information. This non-process energy needs to be clearly defined to allow more quantitative improvements. The utilization of percentage of non-process energy in industrial and manufacturing plants is an important potential source of energy and cost improvements. Previous analysis of industrial energy use often expressed non-process energy as a percentage of total energy, but without clear values of actual non-process energy. This information is a low value since the actual non-process energy is then dominated by the dominator which is unspecified.


Introduction: The aim of this study was to evaluate the correlation between malampathy score, upper lip bite test and 3-3-2 maneuver with anthropometric factors of body in people. Methods: This cross-sectional study was carried out during 2014-2015 in Yazd, Iran. Samples were selected from the whole population using simple randomization and were included in the study after giving informed consent. Baseline and demographic data including age, sex, and anthropometric factors of their body such as weight, height, neck circumference, waist circumference, hip circumference, body mass index (BMI), and waist to hip ratio were gathered in a pre-designed checklist. Then malampathy score, upper lip bite score, and 3-3-2 maneuver were evaluated and recorded by the researcher. Results: 498 people with the mean age of 42.1 ± 16.1 were studied (51% female). In total, 168 (69%) of the studied men and 182 (72%) of the studied women had a BMI higher than 25. 74 (39%) of the men had a waist to hip ratio over 0.93 and 152 (60%) of the women had a waist to hip ratio over 0.81. Results of the upper lip bite test was a score of 3 in 10 (2%) people, result of malampathy test was a score of 3 or 4 in 152 (31%) participants and result of 3-3-2 maneuver showed an abnormal condition in 20 (4%), which indicate the probability of difficult intubation. With an increase in age, based on all 3 methods, the probability of difficult intratracheal intubation rises (p 0.05). There was a significant correlation between malampathy score and upper lip biting with all anthropometric factors of the body. 3-3-2 rule also significantly correlated with weight, height, waist circumference, hip circumference, and BMI, but not with neck circumference (p = 0.328) or waist to hip ratio (p = 0.121). Conclusion: It seems that with an increase in age, based on all 3 methods, the probability of difficult intratracheal intubation rises. However, none of the 3 methods of intratracheal intubation difficulty evaluation have a significant correlation with sex. In addition, according to the results of the current study, a significant correlation exists between upper lip biting and malampathy score with all anthropometric factors of the body assessed in this study. Yet, 3-3-2 maneuver does not have a significant correlation with neck circumference or waist to hip ratio.


The use of systematically derived site location data in defining subsistence systems has increased markedly. However, the logical fallacy in the approach has never been discussed. Sites in a particular environmental setting may have been occupied for a variety of reasons at a variety of times (this is particularly true of "ecotone" sites). As a result, the assumption that a particular adaptive strategy may have been in force is, in the absence of any subsistence data, extremely questionable. Locational data may be useful in formulating hypotheses which can be tested through procurement of subsistence data, but in themselves they cannot be used to demonstrate the accuracy of a hypothetical subsistence system.


Researches on mental health of the only child in China has gone through 30 years.The 30 years' research has certain achievements on psychological differences,intelligence development,personality development,interpersonal relationship,emotion control and other aspects.And there are of course some disputes.Although the present research has certain achievements on perspectives and methods,there is still space to make breakthroughs on the influence of parents on the psychology of only-child parents besides adolescent only-child groups and university students.


Following the end of the war in Bosnia (1992-1995), approximately 90 percent of Bosnia's economic infrastructure and assets destroyed costing more than 20 billion dollars according to the World Bank sources. By the end of the war, the unemployment rate in the new state has reached to 90 percent. With the contribution of the World Bank and other NGOs into Bosnian economic rehabilitation and recovery process, unemployment rate in the country significantly fell to 30 percent. The latest studies in literature illustrates that "Conflict" naturally has negative effects on economic activity, investment climate, financial stability, welfare and growth rate of conflicting parties. Moreover, the link between the risk of conflict recurring level and the low income illustrated in studies must be taken into consideration seriously in the era of global economic recession. The peace and stability in Bosnia maintained by military contribution depends on the success of recovery process of Bosnian economy. However, the global economic recession has been affecting the economic activity in region. In this study, the effects of conflict in Bosnia on economic activity have been illustrated and the recovery process of Bosnian economy from The Dayton Accords to the era of global economic crisis has been evaluated. The role of the World Bank and NGOs in recovery process has been also examined.


4559 Background: Sunitinib is a tyrosin kinase inhibitor with proven efficacy in renal clear cell carcinoma (RCCC). However properly validated molecular predictors of response or toxicity are still lacking. This study aims to identify such genetic markers focusing on the pharmacokinetics and pharmacodynamics pathways of the drug.

METHODS
An observational prospective study involving 15 centers of the Spanish Oncology Genitourinary Group (SOGUG) was designed to collect DNA from RCCC sunitinib-treated patients. Eligibility criteria included patients with locally, advanced or metastatic clear renal cell carcinoma treated with sunitinib in a daily practice setting and no prior systemic treatment (neither chemotherapy nor immunotherapy). A total of 15 key polymorphisms in 8 genes involved in the pharmacokinetics (CYP3A4, CYP3A5, ABCB1 and ABCG2) and pharmacodynamics (VEGF, VEGFR2, VEGFR3 and PDGFRa) of the drug were selected to perform a genotype-phenotype analysis.

RESULTS
From February 2008 trough December 2010, 100 patients have been included. Regarding clinical factors prognostic classification of the MSKC showed a significant correlation with TTP (p=0.014). Among the polymorphisms studied, two VEGFR3 SNPs presented statistically significant associations with sunitinib TTP (HR=4.3, 95%CI= 2.1-8.8, P=6x10-5 and HR=3.6, 95%CI=1.9-6.8, P=10-4, per allele in multivariate analysis), clinical benefit (HR=12.4, 95%CI= 2.0-77, P=0.007 and HR=5.9, 95%CI= 1.3-28, P=0.024, per allele in multivariate analysis) and one of them with OS (HR=7.5, 95%CI= 1.6-35, P=0.01) favouring wild type patients. Two ABCB1 SNPs also showed a significant association with TTP. In relation to toxicities, one CYP3A5SNP showed a trend towards an increased risk for grade 3/4 toxicity (P=0.052).

CONCLUSIONS
To the best of our knowledge this is the first time a relevant role of VEGFR3 polymorphisms in response to first line treatment for renal clear cell carcinoma is found. If confirmed, inhibition of this target could have therapeutic implications.


Elastic ring subject to uniform hydraulic pressure on inner boundary and with two opposite slipless quarter-arcs on outer boundary, noting stress and deformation


My research investigates information visualization techniques that improve the awareness of complex automated activities within digital tabletop interfaces. As a case study, I am exploring digital tabletop board gaming as the context to enable rapid design cycles and easy manipulation of variables, such as level of complexity. Preliminary work has revealed that automation reduces workload; however, it also increases the potential for confusion, restricts flexibility, and may negatively impact the gaming experience. Through a series of laboratory studies, my dissertation research will investigate the impact on awareness and decision making processes of following three factors: 1) persistent display of automation results, 2) animation of automated actions, and 3) user control of automated actions. Finally, a field study is planned to deploy and validate the design concepts explored in the laboratory studies.


Context : Germline mutations in genes involved in the hypoxia sensing pathway (VHL, PHD2/EGLN1, HIF2A/EPAS1) predispose patients to erythrocytosis associated with normal or high serum erythropoietin level. The more frequent mutation, VHL-R200W (R200W), has been identified in homozygous carriers with a congenital erythrocytosis named Chuvash polycythemia. Survival in the Chuvash patients was found to be reduced compared to control groups due to higher rates of arterial and venous thromboses, and to haemorrhagic events. Noteworthily, a characteristic of these patients and their parents, heterozygous for the mutation, is the total absence of tumor development as the opposite of heterozygous carriers of other VHL mutations. Indeed, VHL is a tumor suppressor gene and heterozygous carriers of VHLmutations have von Hippel-Lindau disease and are at high risk of multiple tumors (e.g. CNS hemangioblastomas, pheochromocytoma, renal cell carcinoma). The absence of tumor development in patients with congenital erythrocytosis remained unexplained. The R200W mutation is transmitted within a 340-kilobases haplotype inherited 14,000 to 62,000 years ago from a single founder event. The absence of tumor development in patients carrying the R200W mutation raised the possibility of the presence of a protective element within this core haplotype. Objective: The purpose of this study was to determine the mechanisms underlying the absence of tumor development in patients carrying the R200W mutation, healthy (heterozygous carriers) or with congenital erythrocytosis (homozygous). Methods: We report here one particular family carring a heterozygous R200W mutation associated, for the first time, with a typical von Hippel-Lindau disease (with pheochromocytoma, hemangioblastoma and renal cell carcinoma) (Olswang et al., 1998). We performed a comprehensive study with genotyping, phenotypic analysis, structural modeling, functional and transcriptomic studies of the R200W mutant in comparison to classical mutants involved in von Hippel-Lindau disease. For the first time, the use of inducible expression vectors encoding untagged VHL in the functional studies allowed the observation of very subtle effects. Results: We show that the R200W mutation alone is definitely not associated with the von Hippel Lindau disease because this particular family actually carries another pathogenic mutation, VHL-R161Q, on the same VHL allele, and the double mutated allele segregates with disease. Our genotyping showed that the doubled mutations lies on the Chuvash core haplotype transmitted with the R200W mutation. We can thus conclude that this haplotype does not contain any protective elements against cancer development and that the VHLmutations are, by themselves, predominantly responsible for manifestations of the von Hippel-Lindau disease. Functional studies demonstrate that the function of the R200W mutation is close to the wild type protein and the severity of disease manifestations observed in VHL syndrome is perfectly correlated with a gradient of pVHL dysfunction in hypoxia signaling pathways. Conclusion: We show that the R200W mutation associated with congenital erythrocytosis is at the bottom of an oncogenic gradient. These results validate for the first time in humans the recently proposed "continuum" model of tumor suppression, which differs from the classical Knudson's two-hit model and implies that subtle gene dosage-sensitivity may underlie tumor predisposition. This model may be of major importance in our understanding of tumor risk in patients with erythrocytosis carrying germline mutations in other genes belonging the HIF pathway. Indeed, in rare cases, PHD2 and HIF2A pathogenic mutations also predispose patients to pheochromocytomas or paragangliomas development. Disclosures No relevant conflicts of interest to declare.


This chapter presents some very basic results about the geometry of diffraction from crystals. This is developed in much greater detail in many textbooks but a concise statement of the basic concepts greatly facilitates the understanding of the advanced later chapters so we reproduce it here for the...


Multimodal Biometric System is used to enhance the capability of traditional biometric system. Unimodal system is the one where single modality (physiological or behavioral) is used for providing authentication to an individual. Unimodal system includes some limitations like noisy data, non-universality, inter and intra class variations etc. which have worst effect over performance and system's accuracy. Multimodal biometric system is designed to overcome some of the drawbacks of unimodal system to enhance the performance and accuracy. Multimodal Biometric is one where two or more modalities are fused using different fusion techniques resulting in high performance and accuracy.


This author in the article titled as 'Dispute Resolution Panels: Failed Solution Already' (2012) 341 ITR (Journal) 52 had examined the manner in which the Dispute Resolutions Panels (DPRs) had been functioning and the effectiveness with which they had worked towards the attainment of their stated objectives. The Finance Act, 2012 makes amend and seeks to vary the existing legal set-up governing the DRPs. In this article the author discusses the amendments which relate to DRPs as enacted by the Finance Act, 2012 and their implications on the practical working of these panels. In the view of the author and appraisal of the amendments to the Income Tax Act carried by the Finance Act, 2012 relating to the powers and functioning of the Dispute Resolution Panels in the backdrop of the factual position relating to the disposal of objections by the DRPs in the existing set-up reveals that the twin-objections of expeditious and binding settlement of dispute by the DRP will be lost in the oblivion. Given the infrastructure and work-load in which the DRPs operate, the expansion of their jurisdiction while simultaneously requiring the persons manning these panels to exercise the existing administrative obligations perforce impinge upon the circumstances necessary for judicious adjudication. It is thus is imperative for the Government to examine afresh the institutional positioning and functions of DRP if it is to be saved from turning obsolete. The earlier part of this paper can be accessed at [Dispute Resolution Panels: A Failed Solution Already? http://ssrn.com/abstract=2016864].


This paper describes a unique collaborative action research project that brings together members of the q̓íc̓əy̓ (Katzie) First Nation, post-secondary and K-12 communities, as well as foresters and environmentalists, to restore creeks that have been compromised by land use impacts, forest removal, and global warming.  Identifying creek restoration as a site for multi-system change and wholistic re/conciliation, we explored the following questions:  How can we bring together members of our diverse communities to learn about the dire condition of our watershed and take action to help Salmon? How might this collaborative work strengthen community relationships?  What contextual factors enable and impede the enactment of our vison? Through iterative cycles of action and reflection, intentional trial and error, conversational inquiry, and storytelling, we identified 'guideposts' that will inform our work moving forward.  Our research has illuminated structural changes that could enhance environmental justice for Salmon, such as empowering the caretakers of creeks and rivers since time immemorial as sovereign leaders of restorative projects, affirming the rights of the Land and other sentient beings to receive care, developing leadership structures that serve to unite (rather than polarize) citizens in addressing environmental problems, and forming diverse relational webs that exceed partnerships. Action research, informed by Indigenous worldviews, can play a pivotal role in supporting communities in assuming relational responsibility in caring for the Land and one another.  As Donna Haraway (2016) contends, it is time to 'make kin' outside of our genetic and ancestral ties to 'change the story'.


Different digital age corporate leaders follow different strategic life cycle solutions as they operate across differing complex global business environments. Here, each strategy likely requires agile (and sometimes dynamic) quality solutions. There is considerable scope to develop this next wave of quality safeguards – with the digital age span-of-quality extending throughout the corporate.


Inorganic carbon dioxide and petroleum dual infilling occurred in Wuerxun Depression,Hailaer Basin.Paragenetic sequence of dawsonite-bearing sandstone is ascertained and time frame of inorganic carbon dioxide and petroleum is founded through polarizing microscope identification,scanning electron microscope observation,K-Ar ages measuring of illite and U-Pb ages testing of magmatite.Pre-CO2 minerals are mostly quartz overgrowth and kaolinite.Petroleum began to charge during quartz overgrowth growing.As a continuous process,petroleum infilling began from 120 Ma,reached climax during 90-105 Ma and went on till 63 Ma or later.CO2 infilling,90 Ma foremost with great difference to magmatic ages such as granite and rhyolite,was later than the time when petroleum charged in large scale.Most of zircon grains from lamprophyre have 206Pb/238U weighted average ages of 46.2±2.1 Ma,representing the time of lamprophyre forming.According to the fact that dawsonite and ankerite are the authigenic minerals forming at latest in sandstone,CO2 infilling was relatively late,possibly 46.2±2.1 Ma or later.The dawsonite-bearing sandstone preserved the evidence of oil displaced by CO2.


Based on four physicochemical descriptors (the rigidness descriptor ROM resulted by hydrogen-bonding moieties group and/or rings, the chain mobility n, the molecular average polarizability α and the net charge of the most negative atom q-) derived from the polymers' monomers structure, the support vector regression (SVR) approach combined with particle swarm optimization (PSO), is proposed to construct a model for prediction of the glass transition temperature Tg of three classes of vinyl polymers, including polystyrenes, polyacrylates and polymethacrylates. The mean absolute error (MAE = 13.68 K), mean absolute percentage error (MAPE = 4.22%) and correlation coefficient (R2 = 0.9252) calculated by SVR are superior to those (MAE = 16.74 K, MAPE = 5.30% and R2 = 0.9059) achieved by S-SAR model, and (MAE = 16.83 K, MAPE = 5.27% and R2 = 0.9057) achieved by ANN model for the identical training set (124 vinyl polymers), whereas the MAE = 15.09 K, MAPE = 4.82% and R2 = 0.9253 calculated by SVR are also better than those of MAE = 17.96 K, MAPE = 5.94% and R2 = 0.8952 achieved by S-SAR, and MAE = 16.603 K, MAPE = 5.4% and R2 = 0.9120 achieved by ANN for the same 68 test samples. Furthermore, the MAE, MAPE and R2 for an independent set (10 vinyl polymers) predicted by SVR also reached 14.132 K, 4.25% and 0.9475, respectively. The results strongly support that the comprehensive modeling and prediction ability of SVR model surpass those of S-SAR and ANN models by applying identical training, test and independent samples. It is demonstrated that the established SVR model is more suitable to be used for prediction of the Tg values for unknown vinyl polymers possessing similar structure than S-SAR model or ANN model.


Background: Chronic kidney disease is a devastating disease with clinical and ethical dimensions and major public health problem globally. The cause for CRF include obstructive uropathy, primary glomerular diseases, reflux nephropathy, hypoplastic or dysplastic kidneys. Antioxidants control the oxidative stress caused by reactive oxygen species ,and act as major line of defence, regulating overall health. Aim: 1. To evaluate oxidative and antioxidant status in chronic renal failure disease. 2. To evaluate its inflammatory response in oxidative stress. Methods: 1. Samples were collected from Wenlock District Government Hospital, Mangalore (25 patients with chronic renal failure, 25 normal patients) from Aug. 2007 to Aug. 2008. 2. The Parameters estimated are in plasma (total thiols, total proteins, antioxidant activity, advanced oxidation protein product). In red blood cells suspension % hemolysis, in whole blood (Glulathione), in serum, serum iron. 3. Statistical analysis was done by Mann Whitney U test to determine the significant of difference between two means. 4. Informed and written consent was taken from patients and ethical committee clearance was obtained. Results: I. Non enzymatic antioxidants and total antioxidant activity (TOA): Whole blood glutathione (GSH), Plasma total thiols, Albumin decreased II. Markers of oxidative damage: Advanced oxidation protein products,Iron increased,Percentage hemolysis no increase III. Plasma proteins as inflammatory markers: Total proteins decrease, Globulin increased Conclusion: • In our study the non-enzymatic antioxidant metabolites were found to be decreased in chronic renal failure disease. • There was very highly significant decrease blood glutathione, plasma total thiols and albumin in chronic renal failure disease. Address for Correspondence Dr. Sangeeta Salagar, Tutor, Department of Biochemistry, ESI, Medical College, Gulbarga, Karnataka, India. E-mail:-email@example.com Original article


Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Due to the lack of receptor expression, there are limited targeted therapies available for TNBC. As a result, TNBC patients are primarily treated with chemotherapies such as taxanes. Although TNBCs initially regress in response to taxane treatment, resistance is common. One mechanism of taxol unresponsiveness/resistance is an increase in chromosomal instability (CIN). Increased CIN can confer survival advantages to cancer cells and increase their aggressiveness. However, CIN levels can be leveraged using drugs that inhibit proteins important for chromosomal stability. Combining CIN-inducing drugs, such as taxanes, can improve treatment efficacy or re-sensitize tumor cells to certain drugs by shifting cells towards a state of maladaptive CIN that is incompatible with cell viability. We have found that the non-receptor SRC family kinase YES1 is crucial for chromosomal stability. YES1 is important for cell division, motility, adhesion, and survival in both normal and TNBC cells. Since taxol and YES1 silencing independently increase chromosomal instability, I hypothesized that combining a YES1 inhibitor (YES1i) with taxanes would shift cells toward an irreversible state of maladaptive CIN, decreasing their survival. I found that YES1 mRNA and protein are upregulated in taxane-resistant cells and that YES1 protein expression correlates with the paclitaxel IC50 in a panel of TNBC cell lines, suggesting that YES1 may drive taxane resistance. Furthermore, I found that a selective YES1 inhibitor (CH6953755) synergizes with paclitaxel and improves taxane response in both in vitro and in vivo TNBC models. In addition, the combination of YES1i and paclitaxel treatment increases phenotypes associated with chromosomal instability more than either drug alone. These data suggest that YES1 inhibition in combination with taxanes represents an innovative and novel drug treatment regimen that improves TNBC patient outcomes.
 Citation Format: Natasha Ingles, Katrina Piemonte, Salendra Singh, Kristen Weber-Bonk, Ruth Keri. YES1 is a targetable vulnerability for improving taxane response in triple-negative breast cancer [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P1-13-11.


This study aims to provide the basic data helpful for the improvement of rights and interests of radiological technologists, by understanding the current working environment and if they get the proper reward through the analysis on the perception of appropriateness of current wage and job satisfaction of radiological technologists. Survey was conducted to evaluate the perception of satisfaction with job and wage system, work intensity, necessity of the radiological technologist limit system, and turnover in accordance. The appropriate starting salary was low in case of women and non-capital area, and when the age, academic background, career, and hospital size were lower. The appropriate wage was low in case of women and non-capital area, and when the academic background and hospital size were lower. The negative perception of the necessity to change the wage system was shown in university hospitals. Regarding the work intensity, in case of women and low career, and when the age, academic background, and hospital size were higher, the work intensity was perceived as high. When the academic degree and hospital size were lower, the positive perception of the radiological technologist limit was shown. The turnover intention was high in case of women, and when the age, academic background, career, and hospital size were lower. In order to increase the job satisfaction of radiological technologists, it would be necessary to the appropriate reward and the environment where they could concentrate on work.


Moso bamboo (Phyllostachys edulis) is a critical forest resource in subtropical China, and reasonable cutting management of moso bamboo forests is essential for improving the productivity of bamboo forests, increasing the income of farmers, and improving the ecological environment. Therefore, we set up sample plots with different cutting widths at the Yixing Forest Farm in Jiangsu Province in December 2017. Moso bamboo growth surveys and soil sampling were conducted in May 2018 to study the effects of different cutting widths on the growth and nutrient content of moso bamboo forests. Our results indicate that strip cutting had significant effects on degraded bamboo shoots, the number of new bamboos, and their ratios. Soil elements showed surface aggregation, and cutting increased the soil nutrient content. Principal component analysis showed that stand characteristics (diameter at breast height and number of new bamboo shoots) were positively associated with total phosphorus and available phosphorus but negatively correlated with available potassium, total potassium, and soil organic carbon. A cutting width of 8 m resulted in rich nutrient content, which is suitable for bamboo cultivation. These results will provide theoretical guidance for the formulation of scientific and reasonable strip cutting methods for moso bamboo forests.


Acute graft pyelonephritis(AGPN) is thought to affect the graft and patient survival among the renal transplant recipients.Our objective was to compare these outcomes in those having early AGPN(<6 months from transplant) versus those having late AGPN(>6months from transpant)

 This retrospective study analysed 150 patients who had AGPN over a period of 8 years from 2005 to 2013.They were divided into early AGPN group and late AGPN group .Their baseline characteristics were compared.Predictors of graftloss and mortality were compared using logistic regression analysis.Graft survival and patient survival wereanalysed using Kaplan-Meyer survival plots

 A total of 150 patients with AGPN were analysed.Of these 55.3%(n=83) had early AGPN and 44.7%(n=67) had late AGPN.These two groups were comparable regarding baseline characteristics and immunosuppression.13.3%(n=11) patients in early AGPN group had CMV disease during follow up compared to 3%(n=2) in late AGPN group(p<0.05).26.5%(n=22) in the early AGPN group had prolonged foley's catheterization(>5days) following transplant surgery compared to 7.5%(n=5) in late AGPN group(p<0.05).38.6%(n=32) in the early AGPN group had prolonged DJ stent in-situ(>2weeks) following transplant surgery compared to 19.4%(n=13) in the late AGPN group(p<0.05).Recurrent GPN was more common in the late AGPN group than the early AGPN group-35.8%(n=24) verus 18.1%(n=15).Predictors for graft loss was assessed in patients with AGPN and presence of renal abscess was predictive of graft loss in univariate analysis(HR-6.129 ,95 % CI 1.776-21.154,p-0.004).There were no significant predictors of mortality in univariateanalysis.KaplanMeiyer survival analysis showed decreased death censored graft survival in the early AGPN group(p-0.035).There was no significant difference in the patient survival among two groups.

 Occurrence of early AGPN has significant impact on long term graft survival in renal transplant recipients with no significant effect on patient survival.This study underlines the paramount importance of prevention of UTIs in renal transplant recipients.


With regard to the essence of Metaphor,linguists of different language schools have different interpretations.Contemporary linguists hold that metaphor is not only a kind of linguistic phenomenon,but also is basically a kind of man's thinking mode.Viewing from the respects of both man's construction and interpretation of the similarity metaphor,we may know that the creativeness of metaphor has still more important cognitive value and can embody the essence of metaphor.


Convection algorithms for the multidimensional Euler equations are presented based on characteristic propagation properties, with the aim of following closely the physical transfer of information. As opposed to the one dimensional case, information in two or three dimensional Euler flows is propagated in infinitely many directions, each one corresponding to an arbitrary wave front normal. It is shown that a complete decoupling (diagonalization) of the Euler equations can be obtained by an appropriate choice of wave front propagation directions. Actually,two directions are sufficient, one related to the pressure gradient and another related to the local strain tensor. This new formulation allows the definition of numerical schemes with upwind properties depending only on the local flow properties and not on the mesh geometry.


The behavior of 18000 x 3600 mm welded rectangular truss under external loading was studied in the current paper. The prototype is made of paired steel rolled angular 100h100h7 mm profile. The plates in nodes are tapered and made of the steel 10 mm thick plate. It was selected the loading scheme that identifies the operating mode for this type of construction. According to the results of computer simulation experiment in ANSYS Workbench 14.5 environment the strain-stress state parameters of truss elements at different values of the external loading were obtained. The level of stress in truss nodes was discovered and constructive configuration of gusset plates which enables to increase the fatigue durability by 18.4% was offered. The results obtained are of theoretical and practical interest both for the new trusses design and for control of the remaining lifetime of trusses that are being operated under the cyclic loadings.


A thin film composite membrane comprising a thin film polyamide layer disposed between the porous support and the overcoat layer, and a humectant; wherein when the one-hour test at 25l / m2hr with pure water at 25 deg.] C at the time, the film a value of at least 8l / m2hr / bar, and wherein the outer coating comprises a coverage of at least 10mg / m2 soluble cellulose polymer, which after one hour of continuous cross-flow of water at 25l / m2hr deg.] C and 25 substantially from the film was dissolved.


Because of its position as a port in the cotton trade, Liverpool had a special role in the Civil War. This chapter considers the rival consular activities of North and South, and the secret local commissioning of battle-ships as well as the campaign by both sides to enlist British support. Henry Ward Beecher was one of the key figures in these activities.


The number of staff working in the NHS in 2011 has fallen by the largest factor in 10 years thanks to a decrease in clinical support and infrastructure staff, in particular managers.

The number of doctors in the NHS, however, has increased by 1.8% since 2011 and 3.7% year on year since 2001 to a total of 143 836 doctors, according …


The size effect observed in TiAlNiAu/GaN ohmic contacts (OCs) makes itself evident in the dependence of their relative electrical characteristics R SH , R SK , ρ and geometrical parameter L T on the LTLM test line width Wk . The paper explores the geometry of relief (topography) irregularities and their interface conductivity, indicating the great significance of the fractal geometry for the description of the electrophysical and device characteristics. The regularities discovered can be of great practical importance in terms of OC development and optimization for micro-/nanoelectronics demands.


The first central heating systems were invented at the turn of the 19 century, predominantly for factory buildings and greenhouses. In the following five decades they developed from curiosities to an independent branch of industry and conquered the newly emerging architecture of administration, ecclesiastical, cultural and industry buildings. The main inventions and systems of the individual types of central heating from this period were named in general in older publications such as Vetters Bericht as well as in the current publications written by E. Gallo and C. Manfredi and individual examples were described in more detail. A detailed treatment, comparing the individual central heating types in terms of construction, function principles, integration, dimensions and performance is lacking to date. This paper outlines, how this 'gap' can be closed, by presenting in detail three selected central heating systems of one building type and comparing them with one another in accordance with the aforementioned criteria. The first independent European museum buildings are particularly appropriate for such a comparative treatment. A Europe-wide comparison furthermore facilitates a conclusion as to what extent the British technical innovations were absorbed or modified. The following representative heating systems are considered in this paper: • The steam heating system in Dulwich Picture Gallery, near London (1812) • The hot air heating system in the Alte Pinakothek in Munich (1822-36) • The hot water heating system in Neues Museum in Berlin (1841-55). Through these three buildings, a wide net is cast over the three main central heating types (steam, hot water and hot air heating) as well as the designated period (1 half of the 19 century). The results indicate that one of the main driving forces of the industrial revolution, the steam engine, was also the breeding ground for central heating and that the scientific findings of thermodynamics were used for the dimensioning of the heating systems considerably earlier than previously assumed. 1 BTU Cottbus-Senftenberg, PF 101344, 03013 Cottbus, Germany, email@example.com Innovation and reception Historic heating systems in European museum architecture 5 International Congress on Construction History PREMISE In the wake of the industrial revolution and the shortage of wood fuel associated with it, a multitude of innovations in central heating technology were developed at the end of the 18 and beginning of the 19 century. While some, trusting in the experience of antique and mediaeval heating systems (hypocaust or stone oven heating systems), used air for heat transfer, others invested in more effective heat carriers such as water and steam. The key driving forces for this development were both the continuously growing need for greenhouses as well as the rapidly increasing number of factory buildings. While the former required an artificial climate that was as constant as possible for the cultivation of exotic plants, the latter required a safe, economic and easily operable temperature control for large production halls. New building typologies, emerging as a result of state and administration reforms and intentionally designed for large numbers of people, such as prisons, hospitals, banks and administration buildings, also required a central heating system for the heating of the indoor air, which has to be constantly renewed. Approximately by the mid 19 century, the evolution of the experimental heating system into an independent branch of industry had been accomplished Europe-wide. But how were the individual central heating systems constructed and by whom, how did they function and how were they integrated into the relevant buildings? What do we know about the dimensions and actual performance of these systems? One of these new building typologies, the museum, appears to be particularly suitable for a detailed and comparative analysis of the individual central heating systems in terms of the above questions. Museums were built almost simultaneously in all large cities of Europe and the concept and structure of the buildings were very similar to one another. They were not committed to a 'tradition' and the almost identical technical requirements (fire and humidity protection for the works of art) generally called for the integration of a central heating system. As evidence for this hypothesis, one heating system of a representative museum building will be presented in the following for each of the heat carriers outlined above. TYPOLOGY – CONSTRUCTION, FUNCTION AND INTEGRATION The steam central heating using Dulwich Picture Gallery as an example One of the first public museums, the single storey gallery building in Dulwich designed by Soane 1811-1812, was to be heated both by a modern central steam heating system as well as traditionally by local fireplaces. The main source of heat for the enfilade of five equally wide galleries with skylights was a central steam heating system. The system's pipes were guided in brickwork ducts underneath the wooden flooring and the heat rose through floor grates at regular intervals. In addition to the central heating, Soane also installed a central, open fireplace in both of the long gallery rooms. The mausoleum, situated in the centre of the west side, was intentionally left unheated, in order to strengthen the desired architectural juxtaposition between the two areas. The living areas to the right and left of the mausoleum were equipped with open fireplaces (Fig.1). Soane appointed "Matthew Boulton & James Watt", a company which he held in great esteem, to undertake both the concept and the construction of the steam heating system. In addition to their well-known steam engines "Matthew Boulton & James Watt" also started at an early stage to produce steam heating systems (e.g. in 1799 for the Salford Twist Mill). In order to heat the gallery halls, they installed a horizontal, cylindrical boiler (wagon boiler) at the end of the building, which fed the cast-iron pipes with steam.


We detect with special keenness in contemporary societies the close relationship between communication and temporality. Indeed, communication technologies (with their telecommunication and their networks) brought a singular temporal experience of social life. In this paper we ponder the influence that the present time inflection (based on instantaneity and immediacy) brings to communication. Highlighting, on the one hand, journalism and, on the other hand, the role of media in the configuration of the experience of present time, we give emphasis to some of the risks and potentialities that presentism, seen as a contraction of temporality, brings to the communicational phenomenon.


AMBIVALENT SEXISM AND POSITIVE ILLUSIONS OF PHYSICAL ATTRACTIVENESS IN HETEROSEXUAL ROMANTIC RELATIONSHIPS Michaela M. Engdahl, B.A., M.S. Marquette University, 2015 While considerable research has been devoted to the impact that the mainstream media and parents have on body image, less is known about how romantic partners' beliefs and perceptions impact individuals' evaluations of both their physical selves and their relationships. This study examined the influence of individually-endorsed cultural sexism on romantic partners' tendency to hold positive illusions about their significant others' physical appearance and the impact of sexism and positive illusions of physical attractiveness on body esteem and relationship satisfaction. Evidence of positive illusions of physical attractiveness was found, but there was no significant association between gender and positive illusion endorsement. There was no significant correlation between men's benevolent sexism (BS) and their endorsement of positive illusions. Multiple regression analyses indicated that men's and women's endorsements of positive illusions did not significantly impact partners' body esteem. Instead, results suggest that a person's view of his/her self (i.e., self-ratings of attractiveness) most strongly impacts one's body esteem. Additionally, men's BS was found to positively impact women's Sexual Attractiveness body esteem, while women's BS positively impacted men's Physical Attractiveness body esteem. Women's BS was positively associated with their own Weight Concern body esteem while women's hostile sexism (HS) was found to have a negative impact on this body esteem dimension. Multiple regression analyses did not produce significant findings with regard to women's relationship satisfaction, while men's relationship satisfaction was found to be positively impacted by their positive illusions of partners' physical attractiveness. Implications of these findings are discussed.


SUMMARY Variety, spacing and harvesting date trials with fodder beet were carried out in Cyprus under rainfed conditions. The variety Polyrossa gave the highest dry matter (DM) yield, 12,906 kg/ha. Yield of DM increased linearly with population density to an optimum spacing of 45 × 20 cm. Yields of beet decreased slightly when harvested after 15 June and significantly when harvested after 29 August. Irrigation with saline water increased DM yields.