We reported the first controlled doppler ultrasound study showing increased common femoral vein (CFV) thickness in Behçet's Disease (BD).[1]We also recently showed that increased CFV thickness is a distinctive feature of BD, rarely present in other inflammatory or vascular diseases with a specificity higher than 80% for the cut-off value of ≥ 0.5 mm.2However, the association between CFV thickness and any organ involvement, disease course or treatment during disease course has not been demonstrated so far.This study aimed to assess the longitudinal course and prognostic value of CFV thickness measurement during a prospective follow-up BD patients.In this study, we included 195 patients with a diagnosis of BD. The clinical, demographic, treatment data and biomarkers were recorded during routine visits. Bilateral CFV thickness was measured with ultrasonography by an experienced radiologist at the same day. Patients were started to follow up prospectively with 3-6 months intervals and in any urgent visit.At baseline, 98.6% of patients had increased CFV wall thickness above the cut-off value of ≥0.5 mm. The baseline and last follow-up clinical characteristics were shown in Table 1. 139 of 195 patients had prospective clinical follow-up data with a mean of 26.5 (16.9) months. New major organ involvement or relapse leading to treatment change was seen in 39 (28%) patients. Among 22 (15.8%) patients with new major organ involvement, 12 had vascular, seven had ocular, two had neurologic and one had gastrointestinal involvement.Among 36 patients with only mucocutaneous disease at baseline, new major organ involvement developed in 9 patients during follow-up. These nine patients had higher baseline CFV thicknesses compared to patients without major organ involvement, however without reaching clinical significance (0.83 mm vs 0.73 mm for right CFV, 0.80 mm vs 0.73 mm for left CFV: p >0.05 for both)In 47 patients, the second CFV thickness measurement was done with a mean 19.8 months after the first visit. There was no statistically significant difference between the first and second CFV wall thickness measurements for both right and left CFVs (First vs. second for right CFV: 0.79 vs. 0.76 mm, p=0.26; for left CFV: 0.79 vs. 0.75 mm, p=0.26). We did not find any change in CFV wall thickness with the treatment modality, new organ involvement and relapses.CFV wall thickness measurement with ultrasonography which is a new non-invasive diagnostic tool for BD, does not show a major change over time with treatment modality, new organ involvement or disease relapses. However, our preliminary results suggest that mucocutaneous BD patients with higher CFV thickness may have a higher risk for the development of major organ involvement during follow-up. The long term results of our prospective cohort with increased patient numbers would clarify the prognostic value of CFV thickness in BD.None.[1]Alibaz-Oner F Clin Rheumatol 2019[2]Alibaz-Oner F. Rheumatology (Oxford). 2021Table 1.The baseline and follow-up clinical characteristics of patients with Behçet's Disease.Baseline(n=139)Last Follow-up(n=139)Relapses or New Involvement during follow-upAge mean (SD)34.85 (8.27)Gender F/M ratio43/96Right CFV Wall Thickness mean (SD) mm0.791 (0.253)Left CFV Wall Thickness mean (SD) mm0.797 (0.207)Oral aftous ulcers n (%)134 (95)134 (95)13 (9.4)Genital ulcers n (%)84 (60.4)89 (64.5)6 (4.3)Eritema Nodosum n (%)62 (44.6)69 (49.6)9 (6.5)Arthritis (%)48 (34.5)48 (34.5)10 (7.2)Major Organ Involvement n (%)  Vascular Involvement n (%)84 (60.4)96 (69.1)35 (25.2)  Deep Venous Thrombosis (%)61 (43.9)65 (46.8)6 (4.3)  Pulmonary trombosis n (%)35 (25.2)52 (37.4)23 (16.5)  Sinus Venous Thrombosis n (%)12 (8.6)14 (9.9)2 (1.4)  Trombofilebitis n (%)4 (2.9)6 (4.3)5 (3.6)  Neuro-Behcet n (%)14 (9.9)16 (11.5)2 (1.4)  Uveitis n (%)33 (23.7)40 (28.8)7 (5)  Entero-Behcet n (%)8 (5.8)9 (6.5)1 (0.7)NIL.None Declared.


The concept of an effective light-particle field theory has proven useful for calculations in grand unified theories [l] and in non-leptonic weak decays [2]. In this paper the effective field theory approach is applied to compute heavy particle effects in deep inelastic scattering. This approach was first discussed by Witten Pal ** in a moment analysis of charm quark effects. Here we will discuss band tquarks using an equivalent but more intuitive method which involves dealing directly with the structure functions themselves. We will derive, using the leadinglogarithmic approximation, predictions for the b-quark momentum distribution at Q2>mt utilizing data from the region mf < Q2 < mi. These predictions are reliable only for Q2 >> rni; however, such large Q2 values should be attainable at electron-proton colliders [4]. The basic idea of an effective field theory is that at momentum scales much smaller than some heavy particle mass Feynman diagrams not containing external heavy particle legs can be described by an effective field theory involving only light-particle fields. In electroproduction one is concerned with those Feynman diagrams which contribute to the forward Compton amplitude so in order to apply this formalism one must assume that there are no primordial heavy particle contributions to the wave function of the nucleon. This assumption is suggested by the small measured value of the s-quark distribution [5] and by the success of naive


The world female prison population in 2006 was 660,000 women, representing close to 6.5% of the total world prison population. This particular population has increased 40%, from 2000 to 2013.1 In Perú, female prison population was, in 2015, 4,396.2 Despite the increasing amount of female incarceration, women prisoner still represent an invisible minority in relation to male prison population which is more than 90% of total Peruvian prison population. This is a major factor because it could cause their different needs to be ignored and omitted, prioritizing the needs of the majority, men. It is said that jails were designed for men prisoners; women were just put in there and treated by the same policies that were designed also for men.3–5 Unlike men, women are incarcerated, mostly for minor felonies like theft, prostitution, drug offenses; crimes that are related to lack of money to pay the bills, to maintain their drug addiction and to buy food (most of these women are the only ones who take care of their children).6,7 This means that their situation is much different from men's. Furthermore, they come from marginalized and poor sector and carry histories of physical and sexual abuse, neglect, violence, sex jobs and drug addiction;6 and the majority of them had limited access to health services, which increased their risk to get any disease, especially related to sexual and reproductive health, including gynecological cancer.7 Special attention should be paid to the unique and different women's situations and health, because they are clearly different from men.8


This paper identify and discuss barriers affecting knowledge management (KM) processes in the oil industry. Based on reviewing the literature on this topic, we used a conceptual model comprising the most important barriers, grouped in three categories–organizational, knowledge and people related–influencing four critical KM processes–creation, storage, share and application. Using factor analysis, we identified which barriers influence the most each of the KM process and what are the practical implications for companies operating in the oil industry. This study provides useful insights regarding knowledge processes barriers, enabling top executives to better cope with factors hindering successful implementation of KM initiatives.


Abstract: The pancreatic b‐cell expresses an imidazoline‐binding site that is involved in the regulation of insulin secretion. This site is pharmacologically atypical in comparison with the I1 and I2 sites described in other tissues, and it has been classified as I3. The structural requirements for binding of ligands to the I3 site have not been fully defined, although a range of synthetic I3 ligands have been characterized in functional terms. Evidence has been presented that an endogenous I3 ligand may exist, because extracts of brain contain an active principle that stimulates insulin secretion in a manner consistent with the involvement of I3 sites. The active component has not been identified but has been equated with the long‐sought clonidine displacing substance (CDS) that is proposed as the endogenous ligand for imidazoline‐binding sites. Recent evidence has indicated that one active component of CDS may be a b‐carboline, but it is not known whether b‐carbolines can stimulate insulin secretion. Thus, we have studied the effects of b‐carbolines on insulin secretion and cytosolic Ca21 levels in rodent and human islet cells. The results reveal that harmane, pinoline, and norharmane cause a dose‐ and glucose‐dependent increase in insulin secretion but show that this response differs in a number of ways from that elicited by the well‐characterized I3‐agonist, efaroxan. Thus, b‐carbolines represent a new class of insulin secretagogues, although it remains unclear whether their action is mediated solely by I3 sites in the b cell.


A group of 39 Transgender subjects, 17 Female to Male (FtM) and 22 Male to Female (MtF), have been evaluated about their sexual desire, activity, and satisfaction during the period before and after Sex Reassignment by Surgery (SRS). Visual Analogue Scale from 0 to 10 has been used to assess sexual desire and satisfaction, number of sexual partners and number of sexual intercourses/ month have been evaluated to assess sexual activity. Moreover, after the surgery, the Sexual Desire Inventory-2 (SDI-2) was administered to patients and related to testosterone (total or free) levels. In FtM, after hysterectomy and bilateral ovariectomy, mean value of sexual desire (VAS 0 - 10) was 7.5 before beginning testosterone therapy, this value increased after six months of therapy and after one year. Just before SRS the value decreased, but increased to 8.42 after SRS. In the same patients the values (VAS 0 - 10) on sexual satisfaction were respectively 6.5, 6.9, 7.1, 6.5 and 7. Mean number of partners was 4, with 7.07 mean frequency of sexual intercourse/month, before starting therapy (after hysterectomy). During hormonal therapy (testosterone), No. of partners was 2.46 and 8.96 intercourses/month, while after SRS the partners were 1.25 and intercouses/month 7.91. MtF patients reported a sexual desire (VAS 0 - 10) before therapy of 7, this remained almost constant after 6 months, decreases after 12 months and just before surgery, and finally increased to 7.76 after SRS. For sexual satisfaction mean values of VAS were respectively: 6.1, 6.2, 6.3, 6, and 6.8. Regarding sexual activity, MtF report 3.81 mean No. of partners and 9.27 intercouses/month before the beginning of hormonal therapy, 1.36 partners and 4.36 intercourses after therapy, and 1.3 partners and 4.54 intercourses after SRS.


Social justice school leaders can amplify the voices and activism of marginalized students by shifting from hierarchical relationships to working as allies. An ally is commonly defined as a person who is associated with another or others for some common cause or purpose. By transferring Kendall's (2013) concept of "allyship" from racial privilege to leadership, this paper applies this theory through three dimensions: developing a radar, breaking ranks and creating space for student voice, and making intentional strategic moves. Ultimately, the school leaders highlighted in this study are tipping the balance to disrupt hierarchical relationships between leaders and students, in service of marginalized students.


Two butanolides, subamolide D (1) and subamolide E (2), along with β-sitosterol (3), β-sitostenone (4), lupeol (5), taraxerol (6), and 24-methylenelanosta-7,9(11)-diene-3β,15αdiol (7) were isolated from the leaves of Beilschmiedia glabra. The structures of the isolated compounds were elucidated by extensive spectroscopic data analysis and comparison with respective literature data. The compounds were tested for


Mechanical strength properties of high-temperature ceramics are important to their future utilization in heat engines. Tensile and interlaminar shear data are reported for Du Pont Lanxide`s C/SiC and enhanced SiC/SiC ceramic matrix composites (CMCs). Data were generated for specimens with respect to temperature up to 1,650{degrees}C. C/SiC tensile test showed a constant strength of 530 MPa to 815{degrees}C in an air atmosphere. At 1,650{degrees}C, 74-percent strength was maintained. SiC/SiC reached a maximum tensile strength of 286 MPa at 980{degrees}C, while decreasing to 180 MPa at 1,480{degrees}C. Both materials had good modulus retention with increasing temperature. Interlaminar shear results of the SiC/SiC material exhibited increasing strength up to 1,200{degrees}C in an inert atmosphere. Average shear strength of 40 MPa was obtained at 1,540{degrees}C. Average shear strength for C/SiC increased to a maximum of 66 MPa at 1650{degrees}C.


y Tendencias Además, ABSTRACT 2020 was a year full of challenges to be overcome. Unfortunately, many of our loved ones did not survive the pandemic. Here we present a summary of the global behavior of COVID-19, the number of individuals diagnosed as positive for SARS-CoV-2 and the number of worldwide deaths. We show an overview of the research carried out on COVID-19, as well as the publications that have been presented in BUAP Alliances and Trends. In addition, we present the encouraging news of treatment options and vaccines that have been developed and that are increasingly administered to the population; which could allow us to return to a more active and carefree life.


The development and life history of Nacobbus serendipiticus was studied from the egg to maturity and the early stages recorded by cinematography. There are four moults, the first in the egg. The four larval stages are described and their behaviour in relation to tomato roots. The sex of larvae can be determined at the end of the third stage by the development of the gonads. Damage to the host roots caused by the larvae feeding and invading is followed by necrosis of cortical cells. Galls occur only in association with adult females; they contain a spindle-shaped mass of small cells in which starch grains were found. Of 25 plant species tested for susceptibility, mature females were recovered from eight. The nematodes can survive the winter in England but are probably not indigenous.


The invention discloses an iterative least square method-based MIMO (multiple input multiple output) radar DOA (direction-of-arrival) estimation method, which is characterized in that receiving and transmitting array response matrixes on which dimension-reduced processing is performed are solved by using an iterative least square method. The iterative least square method-based MIMO radar DOA estimation method comprises the following steps: firstly, performing the dimension-reduced processing on echo data matrixes of multiple radar transmitted pulses and the receiving and transmitting array response matrixes; then, establishing cost functions under the least square condition, and solving the cost functions by utilizing a gradient descent-based iterative method; finally, estimating the direction of a target by utilizing known receiving and transmitting array manifolds. Compared with a traditional monostatic MIMO radar array DOA estimation method, the iterative least square method-based MIMO radar DOA estimation method disclosed by the invention directly obtains the DOA estimation of the target, and does not need to perform spectrum peak search. Noise is effectively suppressed by adopting the dimension-reduced processing, and the estimation accuracy under low signal to noise ratio is improved; the estimation, the inversion and the eigenvalue decomposition operation of high-dimensional data covariance matrixes are avoided; the defects that the calculated amount is high and the needed sample number is large when the traditional array DOA estimation method is applied to a monostatic MIMO radar are overcome.


Aim To observe the application effect of blood and urine cystatin C in diabetic nephropathy.Methods Detection of 120 healthy persons and 65 diabetic patients blood and urine cystatin C,creatinine,microalbumin,α1-microglobulin and other indicators was conducted.Based on results of microalbumin diabetic patients were divided into normal and abnormal groups.Results Blood and urine cystatin C in the normal and abnormal group were significantly higher(P0.05).The diagnosis rate of blood and urine cystatin C were 90.8% and 96.9% in diabetic nephropathy.Conclusion Blood and urine cystatin C were sensitive and specific indicators for glomerular damage and renal tubular dysfunction in diabetic nephropathy.


In most countries, sanitary landfill is the most commonly used method to eliminate municipal and industrial solid waste, but landfill produces seriously polluted landfill leachate. Landfill leachate contains many kinds of pollutants: such as refractory organic compounds and heavy metals. In general, there are three methods to treat landfill leachate: leachate transfer, biological processes, chemical and physical methods and membrane processes. Membrane processes can be divided into four types: microfiltration (MF), ultrafiltration (UF), nanofiltration (NF) and reverse osmosis (RO). Membrane process has the advantages of stable effluent and high rejection rate for refractory organic matter. But high treatment cost and membrane fouling problem affect the applications of membrane in practice.


The freezing parsed alignment was proposed with the single-antenna GPS to fulfill the flight coarse alignment of stratospheric aerostat SINS. Considering aerostat's angular motion around vertical channel when moving,the formulas of freezing parsed alignment which can solve the attitude of the aerostat with the velocity measured by GPS were derived. The factors affecting the alignment performance were analyzed. Simulation results show that algorithm is efficiency for the flight coarse alignment of aerostat SINS with the result of horizontal misalignment angle below 8' when the aerostat angular rate within the scope of- 5 ° / s ~ 5 ° / s and the velocity measured error of GPS under 0. 15 m/ s.


Developing optical network optimization algorithms involves representing many different instances related to the network itself: topology, physical layer equipment found in nodes, links, etc. It also requires description of traffic demand. We propose onML; an XML-based structure to fulfill such requirements. The onML structure is used by ONDE, a development environment targeted at optimization algorithms for optical networks. A sought feature of ONDE is a modular design allowing a clear separation of onML files parsing functions, graphical user interfaces and network optimization programs. With such a modular approach, multiple research teams can cooperate to develop and easily share new tools and algorithms. As a result, an XML parser is tailored to parse data in onML-compliant files and is easily interfaced with the main C++ optimization algorithm under development. For graphical user interface aspects, the ONDE environment uses a Java program which is interfaced with the XML parser through the Java native interface (JNI)


CNx/SiCN composite films were prepared on titanium ( Ti ) alloy substrates by Radio Frequency Plasma Enhanced Chemical Vapor Deposition ( RF-PECVD ). As a buffer layer, SiCN ensured the adhesion of the CNx thin films on Ti substrates. X-ray diffraction (XRD) measurement revealed that the composite films possessed α-C3N4 structure.The microhardness of the films was 48 to 50 GPa. In order to test the characteristics of wear and corrosion resistances, we prepared Ti alloy samples with and without CNx/SiCN composite films. Also for strengthening the effect of wear and corrosion, the wear tests were carried out under high load (12 MPa) and in 0. 9% NaCl solution. Results of the wear tests and the corrosive electrochemical measurements showed that the samples coated with CNx films had excellent characteristics of wear and corrosion resistances compared with Ti alloy substrate samples.


This experiment was designed to refine natural ore Alunite and to eliminate impure matter as far as possible and to find out the order and activation energy in the dehydration reaction of Alunite by means of Dynamic TGA method. The same experiment on more impure Alunite was conducted and the result was compared with that of the former experment. The following results were obtained from the above comparison: 1) The activation energy of the impure Alunite was 58.9 cal and the dehydration reaction order was 0.8; 2) The activation energy of the purifide Alunite was 38.4 cal and the dehydration reaction order was 1.0.


and of a model of on the application of cooperative game theory to include water and policy, the assessment of change and policies in the agriculture and water


Pulsing X-ray sources are believed to be the progenitors of binary and runaway pulsars. Thus, their observed properties and predicted fates furnish information about the initial properties and evolution of these pulsars. Evidence is discussed which suggests that many binary and runaway pulsars are born with periods ^ seconds and dipole magnetic fields ^ 10^ ' - 10 G, and that the turnoff of at least some is not due to decay of their dipole magnetic fields.


We consider single trace operators of the form l1...ln = Tr D+l1F...D+lnF which are common to all gauge theories. We argue that, when all li are equal and large, they have a dual description as strings with cusps, or spikes, one for each field F. In the case of = 4 SYM, we compute the energy as a function of angular momentum by finding the corresponding solutions in AdS5 and compare with a 1-loop calculation of the anomalous dimension. As in the case of two spikes (twist two operators), there is agreement in the functional form but not in the coupling constant dependence. After that, we analyze the system in more detail and find an effective classical mechanics describing the motion of the spikes. In the appropriate limit, it is the same (up to the coupling constant dependence) as the coherent state description of linear combinations of the operators l1...ln such that all li are equal on average. This agreement provides a map between the operators in the boundary and the position of the spikes in the bulk. We further suggest that moving the spikes in other directions should describe operators with derivatives other than D+ indicating that these ideas are quite generic and should help in unraveling the string description of the large-N limit of gauge theories.


Due to political decisions regarding the Swedish school, public and independent schools booth face the need topromote themselves in the quest for new pupils. This study aims to, from a communicatio ...


Space alternating data augmentation (SADA) was proposed by Doucet et al (2005) as a MCMC generalization of the SAGE algorithm of Fessler and Hero (1994), itself a famous variant of the EM algorithm. While SADA had previously been applied to inference in Gaussian mixture models, we show this sampler to be particularly well suited for models having a composite structure, i.e., when the data may be written as a sum of latent components. The SADA sampler is shown to have favorable mixing properties and lesser storage requirement when compared to standard Gibbs sampling. We provide new alternative proofs of correctness of SADA and report results on sparse linear regression and nonnegative matrix factorization.


A computer experiment is carried out to study the dynamic behavior of plasma particles in response to self-consistent electromagnetic and electrostatic fields produced by an artificial injection of a dense electron beam into the ambient plasma. A two-and-one-half dimensional electromagnetic particle code (KEMPO) is used for this purpose. The electron beam is assumed to be injected along the external magnetic field, B0, and to have a spatially finite extent in directions both parallel and perpendicular to the beam motion at t=0. Most of the beam electrons are decelerated, and this deceleration is accompanied by an elongation and splitting of the beam. However, a fraction of the electrons in the beam is not decelerated but instead is accelerated in both positive and negative directions along B0. A substantial heating of beam electrons is also observed. Associated with the acceleration and thermalization of the beam electrons, various kinds of electromagnetic and electrostatic waves are excited through wave-particle interactions. On a time scale of ion motion, ions are attracted toward the center of the moving beam, forming an ion density peak, which, in turn, causes a strong acceleration of electrons. A BGK type quasi-steady state is reached and maintained for a finite time.


Introduction: Elderly fit patients (pts) with favorable risk (ELN 2017) acute myeloid leukemia (FR-AML) are traditionally treated with intensive chemotherapy (IC-most commonly 7+3) as induction treatment, based on data extrapolated from studies in pts <60 years (yrs) old. However, advanced age, comorbidities, and poor performance status significantly increase the risk of treatment-related complications and mortality. Younger pts with FR-AML experience a cure rate of 60% with IC-based induction, but outcome with the same in older pts is not well defined. A recent single center study (Lachowiez et al. 2020) in pts with NPM1-mutant AML (>65 yrs) reported improved outcome (1-yr survival rate- 80%) with the combination of hypomethylating agent and venetoclax (HMA-Ven) compared to HMA alone. However, real world evidence continues to lack on efficacy and long-term outcome of intensive and non-intensive induction strategies in very elderly pts (≥70 yrs) with FR-AML, including core-binding factor (CBF)-AML.
 Methods: In this multicenter retrospective study, clinical, demographic, and genomic data were collected by review of records of pts aged ≥70 yrs with FR-AML (ELN 2017), treated at Moffitt Cancer Center, University of Colorado, Yale Cancer Center, and University of Miami. Patients who received IC, HMA-Ven, or HMA alone as induction treatment were included in the final analyses. Survival estimates using Kaplan-Meier statistics and multivariate analysis with Cox regression were performed in SPSS (v.26).
 Results: Out of 101 pts included in our study, 45 (45%) received IC, whereas induction regimens were HMA-Ven in 32 (32%) and HMA alone in 24 (24%) pts [Table 1]. Median age at diagnosis was 74 yrs (range 70-92); pts receiving HMA or HMA-Ven were older (p=0.005) than those on IC. Majority of pts were white (90%), and gender was distributed equally. A performance status (PS) of ECOG ≥2 was noted in 18% pts. Abnormalities in CBF were detected in 29% of pts overall (more commonly in IC group), and 26% had secondary AML. Median bone marrow blast counts were comparable across three groups. No significant difference was observed among groups in frequencies of NPM1, CEBPA, IDH1, IDH2, and FLT3-ITD mutations.
 Median duration of follow up was 31.7 months (mo). Among evaluable pts (n=95), the composite complete remission [cCR- CR + CR with incomplete count recovery (CRi)] rate was significantly better in pts on HMA-Ven, compared to IC (97% vs. 66%, p= 0.002) or HMA alone [Table 2]. CR was noted in 20 (69%) pts receiving HMA-Ven vs. 22 (50%) with IC- based induction (p= 0.237). Overall, 10 (10%) pts died within 30 days of induction, with a trend for higher 30-day and 60-day mortality (18%) with IC (p=0.059). In our study, 34% pts relapsed, with similar early (<12 mo) and late (>12 mo) relapse rates across groups. In pts achieving a CR or CRi, median relapse free survival was 7.93 mo, with no significant difference between cohorts. Total 9 pts (IC-8, HMA-Ven-1), including 3 with relapsed AML, underwent allogeneic stem cell transplant (allo-SCT).
 Median overall survival (mOS) was 25.5 mo in pts with CBF-AML (n=29) and 16.5 mo in NPM1-mutant (n= 67) cohort. Patients on IC had significantly improved mOS than those on HMA alone (24.7 vs. 14.3 mo, p= 0.008, Figure 1); however, it was not an independent predictor in multivariate analysis after adjusting for age, PS, and allo-SCT. No significant mOS difference was observed between pts treated with IC and HMA-Ven as induction regimen (24.7 vs. 19.6 mo, p= 0.836). Estimated 5-yr survival rate was 30% with HMA-Ven, 22% with IC, and 4% with HMA. In pts with NPM1-mutant AML, mOS was not significantly different between IC and HMA-Ven groups (16.6 mo vs. 29.2 mo, p= 0.364). In CBF-AML, mOS was not reached in pts on IC vs. 7.27 mo in HMA-Ven group (p= 0.076).
 Conclusions: Induction treatment with HMA-Ven led to a significantly high cCR rate (97%) in elderly (≥ 70 yrs) pts with FR-AML. There was no significant difference in mOS in pts treated with IC and HMA-Ven, both overall and in NPM1-mutant cohort. Among pts with CBF-AML, mOS was not reached in IC group, with a 5-year survival rate of 47%, although small sample size in the HMA-Ven group limits inference from this comparison. NPM-1 mutant elderly FR-AML pts can be treated with HMA-Ven regimen, whereas elderly pts with CBF-AML should be treated with IC if fit, until further data with HMA-Ven combination is available.
 Figure 1 Figure 1.

 Sallman: Novartis: Consultancy, Membership on an entity's Board of Directors or advisory committees; Agios: Membership on an entity's Board of Directors or advisory committees; Aprea: Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; Magenta: Consultancy; Kite: Membership on an entity's Board of Directors or advisory committees; Syndax: Membership on an entity's Board of Directors or advisory committees; Intellia: Membership on an entity's Board of Directors or advisory committees; AbbVie: Membership on an entity's Board of Directors or advisory committees; Shattuck Labs: Membership on an entity's Board of Directors or advisory committees; Takeda: Consultancy; Incyte: Speakers Bureau. Padron: Stemline: Honoraria; BMS: Research Funding; Incyte: Research Funding; Taiho: Honoraria; Kura: Research Funding; Blueprint: Honoraria. Sweet: Novartis: Honoraria, Membership on an entity's Board of Directors or advisory committees; AROG: Membership on an entity's Board of Directors or advisory committees; Astellas: Consultancy, Membership on an entity's Board of Directors or advisory committees; Gilead: Membership on an entity's Board of Directors or advisory committees; Bristol Meyers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees. Lancet: AbbVie: Consultancy; BerGenBio: Consultancy; Agios: Consultancy; Celgene/BMS: Consultancy; Daiichi Sankyo: Consultancy; Astellas: Consultancy; Jazz: Consultancy; ElevateBio Management: Consultancy; Millenium Pharma/Takeda: Consultancy. Watts: Takeda: Consultancy, Research Funding; Genentech: Consultancy; Rafael Pharma: Consultancy; Celgene/BMS: Consultancy. Pollyea: AbbVie: Consultancy, Research Funding; Syndax: Consultancy; Amgen: Consultancy; Janssen: Consultancy; Genentech: Consultancy; Karyopharm: Consultancy; Novartis: Consultancy; Daiichi Sankyo: Consultancy; Celgene/BMS: Consultancy; Pfizer: Consultancy; Takeda: Consultancy; Agios: Consultancy; Glycomimetics: Other. Zeidan: Genentech: Consultancy; Daiichi Sankyo: Consultancy; Kura: Consultancy, Other: Clinical Trial Committees; Novartis: Consultancy, Other: Clinical Trial Committees, Travel support, Research Funding; Jazz: Consultancy; Amgen: Consultancy, Research Funding; Loxo Oncology: Consultancy, Other: Clinical Trial Committees; Pfizer: Other: Travel support, Research Funding; Geron: Other: Clinical Trial Committees; Cardiff Oncology: Consultancy, Other: Travel support, Research Funding; Agios: Consultancy; Epizyme: Consultancy; Jasper: Consultancy; BioCryst: Other: Clinical Trial Committees; Janssen: Consultancy; AstraZeneca: Consultancy; Aprea: Consultancy, Research Funding; BeyondSpring: Consultancy; Boehringer Ingelheim: Consultancy, Research Funding; Astex: Research Funding; Astellas: Consultancy; Ionis: Consultancy; Incyte: Consultancy, Research Funding; Gilead: Consultancy, Other: Clinical Trial Committees; BMS: Consultancy, Other: Clinical Trial Committees, Research Funding; Acceleron: Consultancy, Research Funding; ADC Therapeutics: Research Funding; AbbVie: Consultancy, Other: Clinical Trial Committees, Research Funding. Komrokji: Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees; Acceleron: Consultancy; Taiho Oncology: Membership on an entity's Board of Directors or advisory committees; Jazz: Consultancy, Speakers Bureau; Geron: Consultancy; PharmaEssentia: Membership on an entity's Board of Directors or advisory committees; BMSCelgene: Consultancy, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau; AbbVie: Consultancy.


Castleman's disease is a rare benign lymph node hyperplasia usually presenting as an asymptomatic mediastinal mass. It can present at any extra-thoracic site where there is lymphoid tissue. The common sites include retroperitoneum, mesentry, axilla, and pelvis. Less than 10% of cases occur in the neck.' Parotid involvement to our knowledge is rare, and only four such cases have been reported in the English l i terat~re. ' ,~


The financial management laboratory is a place used to conduct experiments as well as training related to economics and management sciences. One effort to foster interest in student learning is to develop a financial management laboratory by holding online trading applications and learning by applying the Role Playing method to involve students to be active in learning. This type of research uses class action research with Role Playing method. The population in this study are students majoring in management at the Institute of Informatics and Business Darmajaya. Samples in this study were management students with concentration of financial management. Students who manage investment management courses can practice trade online. Students are assigned to act as brokers. The results of this study inform that the purpose of using Role Playing method is achieved in the fourth cycle. The findings were students' interest in learning is very high, lecturers find it easy to organize student groups and positive student response makes it easy for lecturers to provide information.


In the designing of the cold sheet stamping process of car body parts and suspension, is relevant the problem of obtaining of finite element models with acceptable accuracy. Boundary conditions have a significant impact on the correctness of the model. In order to improve the accuracy of modeling, it is proposed to systematize the data on the boundary conditions of modeling available in open sources and reduce them to a specific algorithm for setting of the boundary conditions for modeling of the cold sheet stamping process of auto components.


It's discussed that Tao Yuanming's life realm is quite calm when he face many agonies of life problems.He resolve the problems by using the attitude of Taoism and Philosophical sect of Wei and Jin Dynasties. It is calm makes him realize the true meaming of Nature and creats the great arts. His calm is influenced by Taoism and philosophical sect of Wei and Jin Dynasties, and overstep the philosophers then.


The independent learning curriculum is a breakthrough that brings changes in the implementation of learning, where students are given the freedom to choose the campus to gain knowledge and skills. The independent learning curriculum does not only affect students but also affects lecturers as educators in universities. Each lecturer can teach at other campuses that have established cooperation in accordance with their fields of expertise and disciplines through visit lectures. This visit lecture activity was carried out for the first time in the Department of Community Education, Faculty of Education, State University of Medan in the 2020 academic year. The implementation of learning was carried out by online, this was due to the Covid-19 pandemic. So far, students' motivation to participate in online learning is still relatively low, many students are not serious in participating in learning. This can be seen from the lectures that have been carried out; there are some students who join the lecture class but they do not sit in it. This happens because the teaching methods of the lecturers are not varied and the learning media are less attractive. So that learning becomes less effective. However, through visit lecture activities, it is expected to increase the effectiveness of learning because they are faced with new lecturers and new teaching methods. This research was conducted in the Department of Community Education by using a quantitative descriptive approach. The number of samples used are 82 people, those were students who have participated in visit lecture activities. The data analysis technique used is the trend test and the trend test of each indicator of the effectiveness of learning through visit lectures can be described as follows: (1) Learning effectiveness through visit lectures seen from the Learning Planning aspect/indicator is in the Effective category with a score range of 20-21.5 and Frequency as much as 42 with a percentage of 51% ; (2) Learning effectiveness through visit lectures seen from the Material Design and Making aspect/indicator is in the Effective category with a score range of 19-20.9 and Frequency of 43 with a percentage of 53%; (3) Learning effectiveness through visit lectures seen from the Material Delivery aspect/indicator is in the Effective category with a score range of 23-25.49 and Frequency of 38 with a percentage of 46%; (4) Learning effectiveness through visit lectures seen from the Learning Interaction aspect/indicator is in the Quite Effective category with a score range of 27.25-29.5 and Frequency of 33 with a percentage of 40%; (5) Learning effectiveness through visit lectures seen from the Evaluation of Learning Implementation aspects/indicators is in the Effective category with a score range of 21-23.49 and Frequency as much as 49 with a percentage of 60%. From the results of the general trend test that has been carried out, it can be concluded that the Learning effectiveness through visit lecture in the Department of Community Education is in the Quite Effective Category with a score range of 116.5-116.5 and Frequency is 30 with a percentage of 37%. ICIESC 2021, August 31, Medan, Indonesia Copyright © 2021 EAI DOI 10.4108/eai.31-8-2021.2313801


We focus on the interaction between a male employee and his supervisor and analyze a game-theoretic model of sexual harassment in the workplace. The male employee is accused of sexually harassing a female employee and the supervisor's task is to gather evidence and then determine whether to legally charge the male employee with sexual harassment. The evidence gathering process is random and concrete evidence is available to the supervisor with probability one-half. Our analysis of this strategic interaction leads to four results. First, we delineate the game in extensive form. Second, we specify the matrix that represents the normal form of the extensive form. Third, we show that there is no pure-strategy Nash equilibrium in the game between the male employee and his supervisor. Finally, we show that there exists a mixed-strategy Nash equilibrium in the same male employee-supervisor game.


Foam has been used as an effective displacing fluid for gas mobility control in enhanced oil recovery (EOR) and subsurface remediation. In this study, a series of core flooding experiments are performed on cores with a wide permeability ranging from 3.3 to 2749 mD to evaluate the impact of foam quality and permeability on foam performance. It is found that the steady-state foam mobility control factor is related to permeability in a non-linear, non-monotonic manner. A full physics, mechanistic foam model is proposed by incorporating a novel flowing foam fraction relation grounded-up from pore-level observations, and a new kinetic expression of foam coalescence rate by oil based on pinch-off foam rupture mechanism into the population-balance framework of Almajid et al. (Advances in Water Resources, 2021, 150: 103877). The proposed model is applied to match foam flow experimental results in the absence and in the presence of oil. Results show that our model captures the high-quality and low-quality foam regimes observed in previous oil-free foam flow experiments. Within the medium permeability range, in the absence of oil, lower gas mobility is observed in the lower permeability core due to faster foam film thinning at higher capillary pressure, while in the presence of residual oil, the difference in foam mobility fades away due to the insignificant impact of capillary pressure on the stability of pseudoemulsion films.


Indus River is one of the largest river basins in the world and is a lifeline for regional economies. Owing to its essential economic value and potential, the sharing of Indus river water remained a chronic source of disputes between its users for decade. In 1947 after the partition of British India was the prelude for the water dispute between newly created India and Pakistan. It was finally mediated by the World Bank through the instrument of Indus Water Treaty in 1960. The enactment of the Indus Water Treaty brought peace and benefited two countries to expand their agriculture around areas of Indus River system. The paper analyzes the key issues and conciliation process, which led to the successful Treaty, its understanding, development in economies and political atmosphere the two countries. The paper also attempts to highlight the new issues and claims put forward by the shareholders of Indus Rivers system, which is the cause of new areas of concern. Lastly, the paper suggests ideas for resolving the dispute and relations viza-viz water in the light of past experience, knowledge and successful history of Indus Water Treaty.


Importance : Existing cerebrospinal fluid or imaging (amyloid and tau PET) biomarkers for Alzheimer disease (AD) are invasive and/or expensive. Biomarkers based on standard blood tests would be useful in research, drug development and clinical practice. Plasma neurofilament light (NFL) has recently been proposed as a blood-based biomarker of neurodegeneration in dementias. Objective: To test whether plasma NFL concentrations are increased in AD, and associated with cognitive decline, other AD biomarkers, and imaging evidence of neurodegeneration. Design, Setting and Participants: We used an ultrasensitive assay to measure plasma NFL concentration in 193 healthy controls (CN), 197 mild cognitive impairment (MCI) and 180 AD dementia patients from the Alzheimer's Disease Neuroimaging Initiative. The study dates were January 2005 to December 2012. The plasma NFL analysis was performed in September 2016. cognitive, biochemical and imaging hallmarks of the disease. The implies a potential usefulness for plasma NFL as a non-invasive biomarker in AD. the hypotheses that plasma NFL concentration is increased in AD, and that it correlates with impaired cognition, neuroimaging abnormalities, and CSF biomarkers of AD pathology.


The Campus Bridge establishes the link between the east and west parts of the new University Campus in Heilbronn, which is divided by the railway. The integral bridge structure, without sliding bridge bearings, is realized by a cable-stayed bridge system with a total length of 122 m. The main span at the rail tracks reaches a distance of 77 m. The bridge, which is curved in plan, reaches a necessary height of 9 meters at the crossing of the railway tracks. It is accessible at both sides by stairways and also by glazed elevator towers. The bridge girder is completely integrated into the stairways. It is formed by a double-compartment steel box girder with a high torsional stiffness. In the area of the railways, the bridge is suspended from an inclined mast with a total height of 31 m by five stay cables. The bridge deck is executed as an orthotropic steel plate with a thin layer coating. Micropiles are used as a deep foundation.The need for an extremely short assembly period and the limitations in the location of the foundation of the mast were a complex task for the engineering team


Objective To investigate the postoperative self-management level of primary hepatic carcinoma ( PHC ) patients and analyzed the associated factors .Methods Self-made questionnaires were distributed to 195 postoperative PHC patients , which included the factors such as diet , treatment, physical activity, patients' emotional and psychology conditions .Results Patients' self-management level ranged from the medium to higher level, with a total score of (6.80 ±1.33).The lowest score was (6.42 ±1.82) related to the treatment . The related factors of postoperative self-management level were including age , education , insurance and per capita annual income .And the differences were significant (χ2 =11.021, 45.365, 87.468, 18.907;P〈0.05).Conclusions Medical workers should ask and observe the condition of patients ' self-management at their referral , and give targeted health education to improve their self-management skills to reduce the incidence of complications and improve their quality of life .

Key words:
Hepatic tumor,primary; Self-management; Data collection


Light endowed with orbital angular momentum, commonly termed optical vortex light, has an azimuthal phase indexed by the orbital quantum number l. In contrast to the two basis states of the optical spin angular momentum, the interest in the information content of optical vortex beams is centred on the assumption that forms a countably infinite set of basis states. The recent experimental observation that group velocity is inversely proportional to l provides a theoretical basis for a practical measure of information transfer. This letter sets an upper bound on that measure in free-space propagation.


Disclosed is without using any PLL, bit clock recovery, to provide a method and apparatus for implementing functions necessary synchronization sequence recovery, the read address recovery and media type recognition. The present invention provides a bit clock recovery apparatus for a digital storage read utilizing synchronization frame, is stored oversampled readout signal in the memory, the synchronization pattern is positioned signals using DSP unit, continuous the distance of the synchronization pattern position calculation, a bit clock is recovered from the knowledge of these distances and data framing structure. .The


In this study, a novel adsorbent was developed based on nickel oxide, strontium oxide and zirconia oxide and was anchored onto graphene oxide to produce a heterogeneous nanocomposite (NiSr–ZrO2/GO) for efficient removal of ammonia from industrial wastewater. The proposed nanocomposite was characterized using FTIR, XRD, SEM, EDX, BET, and TEM techniques. Effects of changing important parameters on the ammonia adsorption such as pH, adsorbent dosage, contact time, and initial concentration of ammonia were investigated. Different models were conducted to study the kinetics and isotherms equilibrium data of the adsorption process. The results revealed that the adsorption kinetics was well‐fitted to the second‐order model. The equilibrium data were well fitted on Langmuir isotherm model with a maximum monolayer adsorption capacity of 181.81 mg g−1 (R2 = 0.997). Adding metal‐containing species to graphene oxide can favorably interact with ammonia.


Over the last three and half decades, China's rapid advancement in development efforts has been accompanied by a conscious effort in projecting itself as a major frontrunner in the economy. Despite being a developing country (Huang, 2015), Chinese President Xi Jinping's announcement in World Economic Forum (WEF) (Bruce-Lockhart, 2017) had hinted China's growing interest in the development of trade and network among countries. The Belt and Road Initiative (BRI) is also one such development put forward to institutionalize China's soft power presence in the world and create harmony with rest of the world. The Initiative has been placed as synonymous to a way of friendly cooperation signaling the project as "Road for Peace" (Kasturi, 2017). China has placed a tremendous amount of effort for its "charm offensive" approach with an estimated US$10 billion spending every year on its global soft power presence (Kurlantzick, 2017). Under the project, China has placed initiatives in approaching for regional connectivity in the South Asia region with China–Pakistan Economic Corridor (CPEC) being regarded as its flagship program. As it goes, of all the projects China has undertaken in the BRI, its ventures in South Asia are considered challenging and need strong cooperation (Stratfor Enterprises, 2017). The unstable geo-politics and security threats in the region pose Beijing with a lot to consider before it can preach about the peaceful connectivity. Most significant of all, the problems in the region will be with India as it has openly expressed its dissatisfaction towards BRI. India not only observes the initiative as a security threat with CPEC corridor passing through the controversial Kashmir area, but also sees it as an initiative to undermine its traditional influence in the region. As such, this paper tries to provide an analytical view of BRI with China's soft power presence in the South Asia region.


It is developing trend of operation training of equipment that the simulated tracking training system is used to operation training.The design request,hardware constitution and design and realization of every software part of simulated tracking training system of a certain self-propelled antiaircraft gun are introduced.It is proved by experiment in army that the problems such as the real-time generation, control,measurement and display of target track are solved.The scout and tracking training of target is realized.


Reduction of 3,5,7,7,10,12,14,14-octamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene (Me 8 [14]diene) with sodium borohydride yields three isomeric Me 8 [14]anes (L A , L B , and L C ). These macrocycles give green trans-[CoLCl 2 ]ClO 4 diastereoisomers. It has been possible to obtain two diastereoisomers each with L A and L B and one diastereoisomer with L C . These isomers give distinct infrared and 1 H NMR spectra. The structures of these isomers have been assigned on the basis of their 1 H NMR spectra. The structure of one isomer, trans-[CoL A αCl 2 ]ClO 4 , has been confirmed by X-ray crystallography


Jim Nelson builds upon his earlier work (1983, 1988), boldly naming what he has been doing all along-body theology. He argues that because "we have mistrusted, feared, and discounted our bodies . . . we have not taken our body experience very seriously in doing [theology]. . . . Body theology . . . is doing theology in such a way that we take our body experiences seriously as occasions of revelation. The three loci of this book's essays represent three of my major interests . . . sexual theology, men's issues, and biomedical ethics." Because this book is not a systematically developed body theology, but is rather a collection of essays that engage in the activity of doing theology from an embodied perspective, readers will find each essay a readable entry into Nelson's thought. Nelson's work with sexuality and men's studies is especially valuable. Nelson elucidates the power of "our inherited sexual dualisms-spirit believed to be essentially diflerent from and superior to body-and its patriarchal counterpart, male believed to be essentially different from and superior to female" (p. 19) insofar as these dualisms shape men's lives, sexuality, and spirituality. He then dcscribcs othcr dualisms that follow from this primary one, countering each with a "countervailing virtue," the good news implicit in our tradition. Nelson's corrective to spiritualized theology is a radically incarnational theology, which takes seriously "the fully physical, sweating, lubricating, menstruating, ejaculating, urinating, defecating bodies that we are . . . [as] the central vehicles ol God's embodiment in our experience" (p. 31) and which asks us to reconsider how we interpret scripture and tradition through the lenses of our sexual and bodily cxpcricncc. As wc examine these interstices, we arc called to relinquish bodyand genitalalienation as well as performance demands upon our scxuality. Nelson's gracious gift to us is cndbling us to discern the value of flaccidity, of "downtime," of grace, of ballsy strength in gentleness and sell-acceptance.


A large l1umber of laws relating to fluid flow through porous media have been published by many investigators. The equation Q= KムP 一 一可L (1) has been known as Darcy' s law(1) for 1aminar fIow of f1uid, in which Q was the rate of f10w of fluid in c. c./sec.,万 theviscosity of f1uid in poises, ムP the pressure drop across medium in dyne/ cm2 , L the length of medium in cm., and K the permeabi1ity of medium. Edward D. KaneωCIted in his paper the following re1ation which was derived from Rainard's paper. 8L甲 ='f~4-;;;'2Q十一Q g e n;z R4 n2 '" I g eπR41. where L':,. P in 1b./inch2 , Q in inch3/sec. L in inches,ザ in1b./Cin.) (sec.), and m = a constant to account for the variation in ve10city through the diameter of the tube g e = conversion factor, 386 (1b. /lb. force) On. / sec . 2)


There is sometimes a perception in the counselling field that work in the area of disability is qualitatively different from all other work. Counsellors can easily disqualify themselves from thinking they have anything to offer when disability is present. This paper highlights the effects and limitations of the sort of thinking which defines clients according to their membership of a particular clinical population and challenges counsellors to consider what they have to offer in this area. The paper describes the utilisation of a solution focused framework with families who have a child or adolescent with a disability. Some examples of the use of the 'miracle' question are described, with a consideration of dilemmas raised where disabilities are long term and unchanging. (author abstract)


The resuh is a little high when determining permanganate index of examination sample. The reason is the negligence of the blank value response of pure water for dilution when it is calculated according to the formula. After the formula is revised, the calculating results of examination sample are all right.


We present an algorithm to generate digital painting lighting effects from a single image. Our algorithm is based on a key observation: Artists use many overlapping strokes to paint lighting effects, i.e., pixels with dense stroke history tend to gather more illumination strokes. Based on this observation, we design an algorithm to both estimate the density of strokes in a digital painting using color geometry and then generate novel lighting effects by mimicking artists' coarse-to-fine workflow. Coarse lighting effects are first generated using a wave transform and then retouched according to the stroke density of the original illustrations into usable lighting effects. Our algorithm is content-aware, with generated lighting effects naturally adapting to image structures, and can be used as an interactive tool to simplify current labor-intensive workflows for generating lighting effects for digital and matte paintings. In addition, our algorithm can also produce usable lighting effects for photographs or three-dimensional rendered images. We evaluate our approach with both an in-depth qualitative and a quantitative analysis that includes a perceptual user study. Results show that our proposed approach is not only able to produce favorable lighting effects with respect to existing approaches, but also that it is able to significantly reduce the needed interaction time.


Static RAM (SRAM) is one of the critical components in advanced VLSI systems whose performance, capacity, and reliability have a decisive impact on the entire system. It offers the fastest memory in the storage hierarchy of modern computer systems. By moving toward the smaller CMOS technology nodes, the back end of the line (BEoL) interconnects are also fabricated in tighter pitch size. Hence, besides the power lines, SRAM word- and bit-line (WL and BL) are also susceptible to electromigration (EM). Therefore, EM reliability of SRAM's WL and BL needs to be analyzed during design technology co-optimization (DTCO) cycle. In this work, we investigate the impact of technology scaling on SRAM designs and perform a detailed analysis on the trend of their EM reliability and energy consumption. Our analysis shows that although scaling down the CMOS technology can result in a 2.68x improvement in the energy efficiency of the SRAM module, it increases the EM-induced hydrostatic stress by 2.53x.


Introduction Studies of supercontinuum generation in photonic crystal fibers or dispersion-shifted highly nonlinear fibers have led to renewed interest in SC generation in other fiber types. For example, it was shown that fibers with a steadily-decreasing diameter in which the dispersive and nonlinear characteristics change as a function of propagation distance can lead to significant enhancement of the SC bandwidth and allow for an additional degree of control of the SC spectrum. In fact, it was the use of fibers with dispersion-varying profiles that motivated in the mid-1990s the pioneering work on SC generation intended for telecommunication applications [see e.g. Morioka et al., 1994a, 1994b, 1995, 1996; Mori et al., 1995]. Of course, it was already well known that efficient adiabatic pulse compression could be achieved in dispersion-varying fibers (Dianov et al., 1986), but these mid-1990s studies, anterior to the development of PCFs, were the first to specifically suggest that fibers with longitudinally-varying dispersion could be advantageous in generating broad and/or flat SC spectra (Lou et al., 1997; Mori et al., 1997). With the development of the theoretical understanding of SC generation process (see other chapters) renewed interest in dispersion-engineering has therefore occurred naturally. In this context, a key result that was reported is the demonstration of coherent SC generation in millimeter lengths of tapered fibers where the diameter of the fiber is controlled as a function of length to a great degree of accuracy (Lu and Knox, 2004).


Objective To investigate the diagnosis,etiology and management of fever of unknown origin(FUO).Methods 124 inpatient FUO cases,from 2009 to 2011,were retrospectively analyzed.Results Among the 124 patients,diagnoses were reached in 120 cases(96.8%),in which 62 cases(51.7%) were infections(54 bacterial infections;6 virus infections and 2 fungal infections),37 cases were rheumatologic diseases(30.8%),and 12 cases were malignant tumors(30.8%).Conclusion The causes of FUO can be found by appropriate clinical examinations.Infection,rheumatologic disease and malignant tumor are the three main causes.


Dynamic Bell towers are structures dating a few thousand years ago while their structural behavior is discovered in detail only now in the last few decades. They are monuments of culture and civilization, witnessing the time when they were built but also witnessing the history of the region around them. Old bell towers are built as a masonry structures and as that stand the test of time to this day. The new ones are made of reinforced concrete, steel or combination of both materials. This research paper presents rational procedure for determination of dynamic characteristics of bell tower in order to have an insight into its true structural behavior and to check occurring of resonance during the ringing of the bells. This methodology was conducted on the bell tower of Cathedral Church "St. Clement of Ohrid" in Skopje.


Using video presentations at lessons should be considered an essential tool a teacher should make use of during the process of teaching a foreign language. This is a way of increasing students' motivation and to facilitate the process of foreign language learning. The combination of sounds and images offers the possibility not only to understand better the target language but also to help identify and correctly apply culturally specific communicative strategies. Students have the opportunity to see and hear the way in which native speakers interact. This is supposed to enhance their communicative competence. In addition, they have the possibility to observe the non-verbal aspect of communication and later on correctly apply it in a conversation of their own. The present article aims at analyzing the way in which clips from modern American films help students learn the English language. The author will try to offer some methodological tips in selecting and adjusting a video presentation at the lesson of English so that it helps develop the students' four basic skills: reading, writing, listening and speaking. Key-words: communicative competence, communication, film clips, interaction, body language, motivation, Windows Movie Maker It is generally acknowledged that the main function of language is communicative. This means that language is primarily used as a form of social interaction. People set goals in their social lives and their ability to achieve these goals depends to a great extent on their communicative competence, that is, on the way they are able to communicate their intentions so that their message is perceived as coherent by the interlocutors. That is why teaching a foreign language should focus above all on how to teach students to use language appropriately in a social context so that they do not fail to communicate efficiently. The structural linguist Noam Chomsky was the first to speak about the concept of 'linguistic competence' which implied that both the speaker and the listener have perfect linguistic knowledge 'unaffected by cognitive and situational factors during actual linguistic performance' (Rickheit & Strohner 2008: 17). In generative grammar, the term "competence" is referred to as 'the implicit system of rules that constitutes a person's knowledge of a language. This includes a person's ability to create and understand sentences, including sentences they have never heard before, knowledge of what are and what are not sentences of a particular


It is necessary to research on wireless position determination technology that enables location based services on Portable Internet. In this paper, I consider the position determination technology based on TDOA belong to trilateration method. That is using the difference of relative distance between base stations and terminal due to the time difference of arrival of downlink signal. In order to design the positioning server, This paper reviews the related research on current status of wireless position determination technology based on TDOA on Portable Internet. And then, it is suggested that system architecture, network interface, the calculation model for position determination, which are adapted to circumstance of portable Internet. Through this research on the positioning server, it is expected to guarantee that low cost and high efficiency of wireless positioning server on Portable Internet will be developed.


Introduction: Diabetes mellitus is one of major risk factors of stroke and it hasn't been established how to manage hyperglycemia safely and quickly in an acute stroke stage, particularly in cases of high-dose insulin users. Case Presentation: A 62-year-old female undergoing high-dose intensive insulin therapy presented with numbness of the right hand. On arrival, serum glucose level was 282 mg/dl and HbA1c 12.8%, although she had daily used total dose of 66 units of insulin. Luseogliflozin, one of sodium-glucose cotransporter-2 (SGLT2) inhibitors, coupled with mild low-carbo diet started under insulin degludec of 10 units. Her fast blood glucose became 73 mg/dl in one week and discharged home. Conclusion: Luseogliflozin coupled with mild low-carbo diet controlled hyperglycemia safely in an acute stroke stage.


Proxemics and expectancy violations theory (EVT) are the groundwork for understanding interpersonal and nonverbal communication. Previous research has indicated students retain information long-term when humor and videos that form memorable messages are incorporated into the classroom. The activity discussed in this GIFT uses the popular comedy show, Impractical Jokers, to help students apply abstract concepts to real-life examples. Several discussion questions are suggested to help students critically analyze the videos and recognize proxemics and EVT. The second set of discussion questions asks students to consider their expectations, how their expectations are formed, why some individuals have different expectations, and why expectations may vary in some circumstances based on proxemics. Limitations of this activity are discussed, and alterations are suggested to address the limitations.


Vibration suppression and disturbance rejection in torsional vibration system are important issue in rolling mill control. The two-mass resonant system which has a motor and a load connected with a flexible shaft is proposed. Model predictive control is applied to two-mass resonant system. The optimization problem with constraints is solved. The simulation results show that the proposed design improves dynamic performance and suppresses torsional vibration of rolling mill system. The validity of this design is confirmed


The PVS Prelude Library is a collection of basic theories about logic, functions, predicates, sets, numbers, and other datatypes. The theories in the prelude library are visible in all PVS contexts, unlike those from other libraries that have to explicitly imported. These theories also illustrate various language features of PVS that are useful formalization aids.


A recent article in Diabetes contains a summary of the Juvenile Diabetes Foundation workshop on hypoglycemia that was held in November 1988 (1). This study and others relating to the ongoing Diabetes Control and Complications Trials show the increased prevalence of severe hypoglycemia among patients practicing intensive insulin therapy. This contradicts the experiences of my insulin-dependent diabetes mellitus (IDDM) patients, all of whom are treated with preprandial regular insulin and longer-acting insulins in the morning and at bedtime. Most of these patients describe their lives before intensive therapy as "roller coaster rides," with blood glucose undulating between very high and very low levels. They are usually grateful for the reduced rate of severe hypoglycemia that they now experience. Why is there such a contrast between our experience and the reports of other investigators? Perhaps a clue lies in a basic principle that I learned when I studied engineering 36 yr ago. For many mechanical and electrical systems, small inputs yield small uncertainty in the outputs, and large inputs cause greater uncertainty or distortion in the outputs. For many IDDM patients, the most significant common inputs, in terms of blood glucose effect, are dietary carbohydrate (CHO) and injected insulin. If both inputs are kept small, the likelihood of wide swings in blood glucose is minimized. In practice, we try to lower the CHO content of IDDM diets to the point where the basal (long-lasting) and prandial (short-acting) insulin doses approximate the amounts usually produced by nondiabetic patients. For most nonpregnant nonobese adults, this is typically ~ 5 6 U/insulin dose (2). The amount of CHO that we recommend is typically 6 g for breakfast and 12 g for lunch and dinner. Enough protein and associated fat is added to each meal to fulfill calorie requirements. As in studies of non-insulin-dependent diabetes mellitus patients reported from Texas (3) and California (4), we find that reduction of dietary CHO also reduces HbA1c, 24-h urinary glucose, serum triglycerides, cholesterol-high-density lipoprotein ratio, and apolipoprotein B-100-apolipoprotein A-l ratio (5). Furthermore, there is reason to believe that the reduction in periprandial serum insulin levels can independently lower blood pressure and reduce vascular disease risk (6,7). The purpose of this letter is to suggest that others investigate the effects of low CHO and insulin on the overall well-being of IDDM patients.


The aim of this study was to investigate the relationship between strategic management of human resources, employee development and organizational learning mediator role in Melat Bank branches in Golestan province. Methodology: The research methodology was descriptive, correlational research is survey. The target population included all employees of Bank Melat Province Golestan 600 people. The sample proportional to the number of people using Morgan table, 234 individuals were randomly selected sampling. Results: The data were collected by library and field methods and tools used standard questionnaires. The reliability of the questionnaire using Cronbach and validity have been confirmed by the content. In order to analyze the data, structural equation modeling using LISREL software is used. Conclusion: The results show the strategic management of human resources, employee development and organizational learning mediator role in Melat Bank branches in Golestan province there is a significant relationship.


The main purpose of this study is to search for planning the effect of hotel market-orientation on the hotel service-orientation and organizational-effectiveness in hotel business. In order to inspect the general concept of mobilities among factors, their types and their movements, and identify what causal relationship will be showed among mobilities of the hotel market-orientation, service-orientation and their efficiency. The results of our study were that market-orientation had a direct and positive effect on service-orientation and organizational-effectiveness and service-orientation had a direct and positive effect on organizational-effectiveness. This article shows that one hotel can keep superior to another in the hotel market, by doing its best for developing market-orientation and service-orientation matching with the trait of the management.


With the several developments in visualization, sensing, perception innovation, and transmission systems, 3D information has considered as main part of real-world applications such as multimedia, medical, architecture, manufacturing, computer vision, security, and more. Acquiring the scene depth information is one of the fundamental demands for some of these applications. Although the extracting of 3D information has been studied for more than three decades in different fields including robotics, computer graphics, and computer vision, it remains a challenge and fundamental issue. Systems with high accuracy, more quality of information and high frame rate of data processing have been a unique research opportunity for numerous researchers in order to control the huge volume data and provide convenient solutions. Therefore, several 3D systems of various types, which have satisfied multiple objectives have been proposed and developed to meet the previous requirements. However, in the last few years, a special attention is devoted to time-of-flight (TOF) technology, which has more features including accuracy, efficiency, low-price and robust alternative for data acquisition compared to other technologies. This paper presents the 3D imaging techniques and acquisition systems that concern with range measurement. The differences in their principles and characteristics are discussed, considering various factors and appropriate method that provides low cost, high accuracy, and rapid range measurement, which allow the future researchers to select the suitable technique in developing their systems.


In view of the importance of affective domain curriculum for gifted children, this is a book which few interested in that subject can afford to be without. Discursive rather than deep, it won't tell you all you ought to know about any one area, but it opens up the whole field to popular readers, and if properly supplemented with applications such as are found in Williams (1970) or Massialas & Zevin (1967), it could prove very helpful. Suggested for professional teacher's libraries, but not for general library holding.


Abstract: This is a case study aimed to evaluate food hygiene and safety practices in Bahri hospitals in Khartoum
of SUDAN during the period of January and May 2015. 7 hospitals were out of 8 were selected. Data was collected
on handing and processing of food including personal hygiene of handlers, handling; processing and storage of raw
and ready to eat food, cleaning and cleaning facilities, equipments, and management using structured
questionnaire with 32 available food service staff, observation check list and interview with supervisors. The study
revealed that majority of food handlers were females (83%). The age of employees ranged from 20 to 40 years,
22% were illiterate and have basic educational levels, none of them attend training on food hygiene and safety, half
of supervisors never heard of HACCP, 43% have clean kitchen equipment that are easily cleanable and made of
stainless steel, 29% of the hospitals stored utensils in conditions that could easily exposed to contamination. 29% of
the hospitals use appropriate clothing (head caps and dust coats) when working in the kitchen. All the hospitals
stored raw materials, chemicals (such as detergents) and other equipments in the same rooms. The study also
showed that the majority of staffs (97%) Washing hands before handling food which could reduce the chance of
food contamination. In conclusion the lack of strong food hygienic and safety systems lead to poor food handling
which could consequently affect the health effects of patients. The study recommended provision of appropriate
kitchens condition with equipment, training of all food services staff to improve their knowledge, attitudes and
practices, and conduct regular microbial quality and time temperature checks of the food.


Delirium is a acute syndrome of disorientation caused by dysfunction of brain tissue and has a many varied symptom. The characteristic symptoms of delirium are conscious disturbance with disorientation and dys-mnesia and emotional disturbance. We experienced a 77 year-old male who had a hallucination and disorientation as well as delirium caused by antipsychotic medication, and whose condition was improved through discontinuing medication and traditional Korean medical treatment. We had given herb medication, acupuncture treatment and decreased medication to this patient, and observed. The patient's delirium symptom ad improved through oriental medical treatment and decreasing medication. It was able to improve a delirium caused by not specified origin and side effect of drug abuse through oriental medical treatment and decreasing medication.


The utility model discloses a cup with adjustable volume and belongs to the technical field of cups. The cup with adjustable volume comprises an inner cup body, an outer cup body and a cup cover, wherein the outer cup body is sleeved out of the cup wall of the inner cup body; the upper end of the outer cup wall of the inner cup body is provided with a sealing ring; a screw is arranged on the outer cup wall of the inner cup body; another screw is arranged on the inner cup wall of the outer cup body; the upper end of the outer cup body is connected with the cup cover; the screw on the outer cup wall of the inner cup body is arranged at the middle part of the outer cup wall; the screw on the inner cup wall of the outer cup body is distributed at the lower half part of the inner cup wall; and the screw on the outer cup wall of the inner cup body and the screw on the inner cup wall of the outer cup body match with each other. With the adoption of the cup, the volume of the cup is changed by the vertical lifting between the inner cup body and the outer cup body, thus the requirement of people on the volume of the cup is met; and with the adoption of the sealing ring, the water leakage between the two cup bodies when the cup bodies are contained with water is avoided.


This article, after deliberating on utility of performance evaluation (PE) for the judiciary and practices developed in different jurisdictions for PE, examines existing rules on PE of magistrates in India. From these rules, effectiveness and utility of criteria formulated for PE of magistrates by different high courts is mapped to show their shortcomings, and suggestions are provided for improvement. The article relies on the results of a survey among 35 senior district judges to understand how evaluators see their role in the PE. In the end, some suggestions are offered for reforming the existing system of PE – like delinking it from annual confidential reports, establishing independent commission for PE, adopting transparency in PE, widening gap between two evaluations and making PE as a deciding factor for upward career mobility of magistrates.


Cardiac output was measured in dogs using 5 percent saline as the indicator and a new type of electrically calibrated catheter-tip conductivity cell in the aorta. Paired values of cardiac output were compared using the direct Fick method. It was found that saline cardiac outputs overestimated the Fick values by about 15 percent on the average. Use of the electrically calibrated catheter-tip conductivity cell in the aorta is very easily applied; it does not require special preparation of the indicator or mixing calibration solutions and does not require withdrawal of blood. Cardiac output measurements can be made every few minutes.


The feasibility of soybean-maize succession under the no-till system in the Brazilian cerrado depends on adequate amounts of straw on the soil surface, which can be obtained by intercropping maize with perennial forages. This study aimed to evaluate mass yield and burn-down easiness for nine perennial forage species. The species were grown intercropped with maize from March to July 2009. In October, plants were cut at 0.20 m above ground and 20 days after cut, glyphosate was applied at the following doses: 0.72, 1.44, 2.06, and 2.88 kg a.e. ha-1). The effect of the doses was evaluated 10 and 20 days after application, by weighing and oven-drying the straw at 60 oC. Control was considered excellent when moisture of the desiccated plants was less than or equal to 30% and the forages were grouped according to burn-down easiness: 1) Urochloa (Syn Brachiaria) ruziziensis, Megatyrsus (syn Panicum) maximum cv. Massai, and M. maximum cv. Aruana as the most easily controlled; 2) U. decumbens cv. Basilisk, U. brizantha cv. Xaraes, and U. brizantha cv. Marandu, as intermediary; and 3) M. maximum cv. Tanzânia, M. maximum cv. Mombaca, and B. brizantha cv. Piata, as the hardest-to-kill. Considering biomass production, the shorter interval between herbicide application and plant death, and the glyphosate dose, U. ruziziensis (0.45 and 1.29 kg a.e. ha-1) and M. maximum cv. Aruana (1.41 and 1.66 kg a.e. ha-1) presented the most burn-down easiness, aiming at soybean plant succession.


nous VSDs has been well described [4, 5] . Percutaneous approaches to conal septal VSDs have proven more challenging given the inherent deficiencies of adequate septal tissue below the aortic or pulmonary valve coupled with the risk of semilunar valve disruption by most double disk devices made for muscular VSDs. Still not all conal septal VSDs are created equal, with some being more amenable to percutaneous approaches at closure. As such, prior interventional papers have further categorized conal septal VSDs based on the anatomic feasibility of interventional closure as: (1) subpulmonary VSDs have a muscular rim <2 mm below the pulmonary annulus (i.e., are not suitable for a percutaneous approach), and (2) intracristal VSDs have a muscular rim ≥ 2 mm below the pulmonary annulus (i.e., may be suitable for a percutaneous approach with asymmetric disc devices) [6] . In the latest issue of Cardiology , Dr. Cui and colleagues report the largest published case series involving the closure of intracristal VSDs with the O eccentric shape VSD occluder (Shanghai Shape Memory Alloy Co. Ltd; SHSMA) [7] . Various SHSMA occluders have been described previously for closing select atrial septal defects and patent ductus arteriosus in addition to prior smaller reports for intracristal VSDs [6, 8, 9] . This device was specifically designed to be asymmetric, with a smaller disc on Ventricular septal defects (VSDs) are among the most common cardiac defects, present in approximately 50% of all patients with congenital heart disease, with an estimated prevalence in the population of about 0.3 per 1,000 live births [1] . VSDs are classically categorized by the precise anatomic location of the defect involving the membranous, inlet, muscular, or outlet septum in addition to the physiologic relationship between ventricles (restrictive vs. nonrestrictive). Conal septal VSDs involve a deficiency in the outlet or infundibulum septum; the nomenclature for these defects is redundant and often confusing, using terms such as supracristal, conoventricular, outlet, doubly committed subarterial, juxta-arterial, and subpulmonary. Conal septal VSDs imply an absence of fibrous continuity between the aortic and pulmonary valves, and can lead to prolapsing of the right coronary cusp of the aortic valve and significant aortic valve disruption over time. As such, there is a lower threshold for recommending surgical VSD closure at an early age for these types of VSD [2] . In 1987, Locke and colleagues performed the first percutaneous VSD closures using the Rashkind double umbrella device, which interestingly was originally developed to treat patent ductus arteriosus [3] . Subsequently, percutaneous closure for muscular and select membraReceived: April 18, 2017 Accepted: April 18, 2017 Published online: May 13, 2017


The performance of dynamic property of the mount is influenced by multiple factors and strongly depends on the working conditions. This means that the modal parameters of powertrain mounting system would make changes under different operating conditions. A novel approach to simulate the actual working condition is proposed in the testing of dynamic stiffness. Then the mechanical model of powertrain mounting system based on dynamic stiffness is established in this paper. In order to examine the rationality and accuracy of the computational model based on dynamic stiffness; experimental modal analysis is performed by multiple means and methods in this paper. Through the contrast analysis, advantages and disadvantages of these methods are illustrated and it is shown that using the method of Operational Modal Analysis could obtain more accurate and more reliable results. Based on the experimental and evaluation results, it is shown that there is smaller relative error and higher fitting degree between the calculation results based on dynamic stiffness and the results obtained from operational modal analysis. Moreover, the proposed method also enjoys satisfactory consistency with the actual working condition.


Ceremonial dance in ancient ruins of southern Isan is a part of culture that has been visible in Thailand since antiquity. Despite changes to the social and cultural landscape of the nation, ceremonial dance has been preserved, although the latest waves of modernity are threatening to destroy the art form. It is now vitally important for local communities to conserve and pass on knowledge of their rituals and customs to future generations. This qualitative research examines the background and current conditions of ceremonial dance culture in order to suggest a model for future preservation, which can be employed by local communities to prevent the disappearance of this ancient art.


Following the discovery of insulin by Banting and Best in 1922, it was widely assumed that human diabetes was due exclusively to a deficiency in the secretion of the hormone. However, 10 years later Himsworth (1) noted variations in the responses of diabetic patients to insulin and proposed the notion that insulin insensitivity, not insulin deficiency, was the defining biochemical defect in many diabetics. This idea was not considered seriously until the development of the radioimmunoassay by Berson and Yalow (2), who showed that subjects with adult onset (type 2) diabetes tended to exhibit higher than average levels of circulating insulin. Later studies from Roth (3), Reaven (4, 5), Olefsky (6), and others corroborated these findings and provided a mechanistic basis for the idea that insulin resistance plays a major role in diabetes.

We now know that the pathophysiology of type 2 diabetes involves defects in three organ systems that conspire together to produce abnormal glucose and lipid metabolism (7). While there is some uncertainty regarding the primary lesion and the relative importance of the different tissues, metabolic defects in liver and in peripheral target tissues, such as fat and muscle and pancreatic β cells, all contribute to the syndrome. Insulin resistance, which is defined as a state of reduced responsiveness to normal circulating concentrations of insulin, is now recognized as a characteristic trait of type 2 diabetes and contributes to abnormalities in all of these tissues.

Various prospective epidemiological studies across several population groups indicate that type 2 diabetes progresses over a continuum of worsening insulin action, beginning with peripheral insulin resistance and ending with a loss of insulin secretion (Figure (Figure1).1). In most patients, insulin resistance can be detected long before the deterioration of glucose intolerance occurs. Insulin resistance is a quite common state, associated with aging and a sedentary lifestyle, as well as a genetic predisposition. The state seems to be fueled by, or perhaps to a certain extent the result of, obesity. The ensuing dysregulation of carbohydrate and lipid metabolism that occurs as a consequence of insulin resistance further exacerbates its progression. β cells of the pancreas normally compensate for the insulin-resistant state by increasing basal and postprandial insulin secretion. At some point, the β cells can no longer compensate, failing to respond appropriately to glucose. This ultimately leads to the deterioration of glucose homeostasis and the development of glucose intolerance. Approximately 5 to 10% of glucose-intolerant patients in a given year progress to frank diabetes, which continues to worsen as insulin resistance increases. Adipose cells generate more fatty acids, the liver produces more glucose in an unregulated fashion, and the β cells undergo complete failure, resulting in the late stages of the disease, where high doses of exogenous insulin may be required.

Figure 1

Metabolic staging of Type 2 diabetes

Even in the absence of diabetes, insulin resistance is a key feature of other human disease states. Impaired insulin action coupled with hyperinsulinemia leads to a variety of abnormalities, including elevated triglycerides, low levels of HDL, enhanced secretion of VLDL, disorders of coagulation, increased vascular resistance, changes in steroid hormone levels, attenuation of peripheral blood flow, and weight gain. Thus, insulin resistance is often associated with central obesity, hypertension, polycystic ovarian syndrome, dyslipidemia, and atherosclerosis. This constellation of symptoms is often referred to as syndrome X, or insulin resistance syndrome (8). Whether impaired insulin action is directly responsible for all of the symptoms in these patients remains unclear. However, the broad prevalence of insulin resistance and its association with profound metabolic abnormalities are widely accepted.

In this Perspective series, we will attempt to provide some insight into the pathophysiology of insulin resistance. Before considering the molecular basis for this disorder, it is essential to understand the pathways involved in normal cells. Jeffrey Pessin and I discuss the cell biology of insulin action, speculating about possible molecular defects responsible for the attenuation of the actions of the hormone. Gerald Shulman focuses on changes in glucose metabolism that are characteristic of patients and animal models with insulin resistance, in an attempt to identify key alterations in metabolic pathways caused by impaired insulin action. Because it is critical to fully understand the etiology of insulin resistance, Michael Stern hypothesizes about the genetics underlying susceptibility to this state, and the interaction between genes and the environment. Takashi Kadowaki presents an update on animal models of insulin resistance, which have led to startling insights into the basis of this disorder. Kenneth Polonsky and colleagues discuss the interaction between insulin resistance and insulin secretion, exploring the mechanisms leading to states of decompensation that result in diabetes. Jeffrey Flier and Barbara Kahn discuss the complex role of obesity in relation to insulin resistance, concentrating on how the central control of energy uptake and expenditure might also directly influence insulin action in peripheral tissues. The impact of insulin resistance on the cardiovascular system is a critical area for understanding the risk factors associated with this state. Henry Ginsberg surveys this field by escaping from the glucocentric view of most diabetologists, to focus on the regulation of lipid and lipoprotein metabolism. Finally, Jerrold Olefsky discusses new pharmacological approaches designed to enhance insulin action and thus to reverse insulin resistance and the mechanisms by which certain of these drugs may exert their effects.


ORTAP was developed to predict the dynamic behavior of the high temperature gas cooled reactor (HTGR) Nuclear Steam Supply System for normal operational transients and postulated accident conditions. It was developed for the Nuclear Regulatory Commission (NRC) as an independent means of obtaining conservative predictions of the transient response of HTGRs over a wide range of conditions. The approach has been to build sufficient detail into the component models so that the coupling between the primary and secondary systems can be accurately represented and so that transients which cover a wide range of conditions can be simulated. System components which are modeled in ORTAP include the reactor core, a typical reheater and steam generator module, a typical helium circulator and circulator turbine and the turbine generator plant. The major plant control systems are also modeled. Normal operational transients which can be analyzed with ORTAP include reactor start-up and shutdown, normal and rapid load changes. Upset transients which can be analyzed with ORTAP include reactor trip, turbine trip and sudden reduction in feedwater flow. ORTAP has also been used to predict plant response to emergency or faulted conditions such as primary system depressurization, loss of primary coolant flow and uncontrolled removalmore » of control poison from the reactor core.« less


Taking culture solutions of YSQ-2 fungi as research object,the removal of Cr(Ⅵ) and the adsorption of total Cr by two culture solutions without and with fungi culture for 72 h were compared.The results showed that both the two culture solutions could remove Cr(Ⅵ) effectively,but the efficiency of the culture solution with fungi culture was better than that of the culture solution without fungi culture.The difference in the removal of Cr(Ⅵ) between the two culture solutions was 27%,20.6% and 9.1% when the solution amount was 95 mL,50 mL and 10 mL.The two culture solutions had a negligible adsorption effect on total Cr.Semi-permeable membrane was used to extract the extracellular polymeric substances(EPS) of YSQ-2.The removal rates of Cr(Ⅵ) by YSQ-2 EPS of 1.00 g,0.50 g,0.25 g and 0.10 g were 26.9%,13.7%,6.20% and 2.64% respectively.Similar with the culture solutions,the EPS had no adsorption effect on total Cr also.It was concluded that the EPS of YSQ-2 might play an important role in Cr(Ⅵ) removal by live YSQ-2 fungi,but had no contribution to total Cr adsorption.


The utility of sentinel lymph node (SNL) biopsy (SLNB) as a predictor of axillary lymph node status is similar in patients who receive neoadjuvant chemotherapy and patients who undergo surgery first. The authors of this study hypothesized that patients with positive SLNs after neoadjuvant therapy would have unique clinicopathologic factors that would be predictive of additional positive non‐SLNs distinct from patients who underwent surgery first.


Spoken English is very important in English learning and teaching.As teachers of English, we should first speak more English to foster their ability of speaking.By more practice the students can speak fluent English and express themselve freely.The students mastering good oral English can also help themselves to use what theyve learnt and improve other abilities.\;


Muscle cramps are a common and annoying symptom in patients with amyotrophic lateral sclerosis (ALS). A previous study reported that 95% of patients with ALS experience muscle cramps during the disease course.1 Up to 20% of patients have severe and frequent (more than once/day) cramps, and sleeping is disturbed in 50%.

The origin of muscle cramps is uncertain, but distal motor axons potentially contribute to ectopic burst activity and thereby muscle cramps. Nerve excitability measurements have disclosed hyperexcitable state of motor nerve in patients with ALS.2 Hyperexcitability leads to fasciculations and muscle cramps, and potentially enhances motor neuron death, via glutamate-induced excitotoxicity and increased oxidative stress and metabolic demand.

In line with this view, patients with ALS with hyperexcitable motor nerve, measured by nerve excitability measurements, have shorter survival.2 The relationship between muscle cramps and ALS progression has not been elucidated. The aim of this study was to reveal characteristics of muscle cramps and their relationship with disease progression.

### Subjects

Forty-three consecutive patients with sporadic ALS (29 men), who fulfilled the Awaji diagnostic criteria for definite or probable ALS, with sporadic ALS (29 men) were included in this study. They were evaluated according to ALS Functional Rating Scale-Revised (ALSFRS-R) at first visit.3 Initial weakness, including …


Sub-provincial regional income multipliers in the Ontario economy: an inputoutput approach. This paper considers the feasibility of reducing regional income disparities by selective expansion of particular industrial groups. An inputoutput model is developed, and data for forty-eight industries and ten economic regions of Ontario are employed as a case study to deduce regional income multipliers. The empirical results of the study indicate that regional income differentials can be reduced relative to the 'central core' if industries for expansion are carefully chosen. But, in general, growth in any outlying region relative to the 'central core' is difficult to achieve. The model and the derivations of regional total and wage income multipliers represent a potentially fruitful approach to the analysis of regional economic policy.


Bariatric surgeons have anecdotally reported changes in eating habits of obese people following gastric bypass surgery (GBS), which is believed to be the result of modified food and taste preferences as opposed to restrictions imposed by the bypass itself. Only limited systematic evidence available suggests that consumption of fatty foods is reduced while vegetable consumption increased following GBS. This pilot study aimed to compare dietary intakes before and after GBS in a cross-sectional UK sample. Data were collected from patients at the Imperial Weight Centre in Charing Cross Hospital using a modified 3-d food diary that included questions on postprandial sensations. The diaries were included into routine pre and 8-week post-operative questionnaires. Data are available on twenty-four pre-operative patients and eleven post-bypass patients. Diaries were analysed using Dietplan6 software. As expected the bypass patients had significantly lower mean energy intakes 7937.04 (SD 3217.49) kJ/d in the pre-operative group and 5171.42 (SD 1958.11) kJ/d in post-bypass group, (P = 0.02). Although the number of grams of protein, fat and carbohydrate consumed were significantly lower in the bypass group, the relative contributions to energy intake from the macronutrients were unaltered, (P = 0.4). Following surgery it is recommended that the bypass patients take a multivitamin tablet, and as a result the post-bypass patients were consuming significantly more Cu, Zn, Se, vitamins B, D, E, B1, B2, B3, folate than the pre-operative patients. There were no significant differences in the mean amount of fruit and vegetables consumed between the groups: 2.8 (SD 1.1) and 2.5 (SD 1.2) portions/d for the preoperative and post-bypass groups, respectively. Postprandial sensation data indicated that a third of post-bypass patients reported feelings of nausea, particularly after the consumption of acidic foods or cheese. This pilot study did not find any change in dietary intake in terms of relative amounts of macronutrient intake following GBS. Sensation of nausea following intake of certain foods deserves further research. Increasing the sample size to provide reliable evidence on taste preferences and food choices of post-operative GBS patients is required, in order to provide appropriate dietetic advice.


The author discusses "inflation targeting in an open economy and, in particular, about the choice between "strict" and "flexible" inflation targeting."


Electronic Article Surveillance (EAS) Radio Frequency (RF) label detection system is badly subject to industrial frequency interference and pulse interference.The ill influence results in greater deviation of products measurement,even results in a wrong judgment of RF label quality.A new digital filtering method combining sliding mean filter and the peak pulse interference filter was proposed to filter the sampling value of RF label.The result showed that error rate of judging the quality of RF label had dropped to one-thousandth below.The anti-interference problem of EAS RF label detection system has been solved and the reliability and stability of the system has been markedly improved by this method.