Alternating magnetic fields have been measured in a variety of different cars, the dominant contribution being from magnetized tires. Magnetic field strengths have been measured as a function of frequency directly at the tires and at different positions in rolling cars. Measurements at the tires showed field strengths up to 100 microTesla. In the interior of rolling cars, close to the wheels at foot regions and at the back seat, field strengths of several microTesla were obtained in the 10 – 200 Hertz frequency domain. In some cases measured field values were considerably higher than those found in previous studies. Purposely magnetizing single tires made it possible to study the influence of various parameters. Degaussed tires retained low field values over prolonged time under conditions of normal use.


In an era of aging populations and rising health-care costs, the shift of medical paradigms towards rapid, accurate, early diagnoses of diseases is inevitable. In addition to further development of ultrasensitive in vitro tests, the focus of attention in both diagnostics and the early drug discovery process is increasingly trained on the cell. The immense complexity of biological processes in disease requires developing enabling tools and technologies capable of rapid, dynamic imaging of high-content information with high spatial and temporal resolution. This enterprise automatically requires crosscutting multidisciplinary teams that can integrate advanced imaging and detection technology, fundamental biological and biochemical knowledge, bioconjugate chemistry, nanotechnology and advanced image processing and data storage. Below I present a short summary of key enabling technologies currently in use or in development, and explore challenges for the future.


High electron beam quality is required in Ultrafast Electron Diffraction (UED) to achieve high spatial resolution. However, aberrations mainly induced by solenoid lens will deteriorate the beam quality and limit the resolution. Spherical aberration introduces the largest distortion which is unavoidable in the case of static cylindrically symmetric electromagnetic fields on the basis of Scherzer's theorem. In order to reduce the spherical aberrations, different models have been designed which are composed of three symmetrical lens and one asymmetrical lens. We obtain the magnetic field distribution and calculate the aberration of each model by OPERA, and the result is that the solenoid without poles has the minimum aberration and meets the design requirement best. INTRODUCTION Ultrafast Electron Diffraction (UED) is the primary tool for material science, chemistry, physics, biology and industry with nanometer and sub picosecond resolution. The electron beam is accelerated to 3 MeV in microwave electron gun. After passing through the solenoid lens, the electron beam diffracts on the sample and finally produces the diffraction pattern on the fluorescent screen. By analyzing the diffraction pattern, the information of the material microstructure with atomic resolution can be obtained. Solenoid magnetic lenses are usually used for transverse focusing of electron beams, but the aberration inevitably exists, which leads to the emittance growth and degrades performance in the system. In this paper, the beam emittance growth caused by aberration is theoretically derived and four models including three symmetric lens and one asymmetric lens are designed guided by this theory. We obtain the magnetic field distribution and calculate the aberration of each model by OPERA, and the result is that the solenoid without iron yokes has the minimum aberration and meets the design requirement best. EMITTANCE GROWTH CAUSED BY ABERRATION Magnetic Field Distribution of Solenoid Lens Axisymmetric magnetic field generated by electrified coils can be used for focusing electron beams. The magnetic lenses with and without ferromagnetic material outside the coil are called electromagnetic and ironless magnetic lens respectively [1]. The magnetic field distribution of the electromagnetic lens is more concentrated, and the focusing ability is stronger when the current is the same as shown in Fig. 1. The distribution of magnetic field is related to the shape of the yoke and poles, which determines the aberration. All the magnetic lenses discussed in this paper are electromagnetic lenses. Figure 1: Magnetic field distribution on the axis with and


The application and effect are described of project management information system P3e / c software in 1 200 kt / a ammonium phosphate project of Yunnan Three Circles-Sinochem Fertilizers Co.,Ltd.,and the practice experiences are also presented.


Research has suggested that children's knowledge and perceptions of health related issues contribute to the efficacy of health care intervention strategies and compliance (Berry et al., 1993; McElreath & Roberts, 1992; Potter & Roberts, 1984; Roberts et al., 1981; Santilli & Roberts, 1993). In addition, research regarding the Children's Health Belief Model (Bush & Ianotti, 1990), as well as logical assumptions, have indicated an influence of the child's primary caretaker in the child's formation of health beliefs. The current study evaluated overall trends in parent's and children's knowledge and perceptions of Attention-Deficit I Hyperactivity Disorder (ADHD). Thirty-one parent-child dyads (ages 6 to 17 years) completed an ADHD Knowledge and Perception Survey, which yielded findings reflecting a moderate relationship between parents' and children's perceptions of ADHD.


Pt nanoparticle was electrodeposited on carbon nanotube(CNTs).Scanning electron microscope(SEM) and energy dispersion spectrum(EDS) were used to specify the morphological and elemental analysis of Pt/CNTs electrode.Cyclic voltammograms showed that Pt/CNTs exhibits a greater catalytic effect on L-cysteine than Pt/carbon.Furthermore,the chronopotentiometric curve showed that the linear response range of Pt/CNTs electrode for L-cysteine is 0.5-100.0 μmol·L~(-1) with a detection limit of 0.3 μmol·L~(-1).


Any improvement effort made without the support of quality teacher performance will not possibly work well to help enhance high-quality education. High teacher performance is influenced by many factors. Theoretically, one important factor is principal managerial competency. However, how this factor influences teacher performance is under-researched, particularly in Bandar Lampung schools. This study aimed at investigating the influence of principal managerial competence on teacher performance in public vocational high schools in Bandar Lampung. This study used a quantitative research design, using a questionnaire of which its validity and reliability were ensured before data collection. The samples of the research were 88 teachers from nine vocational high schools in Bandar Lampung City, Lampung Province, Indonesia. The data collected were analyzed using descriptive statistics and simple regression, with the help of SPSS version 24. Results showed that principal managerial competence positively and significantly influenced teacher performance in public vocational high schools in Bandar Lampung. This study recommends the whole stakeholders to pay more attention and to evaluate the principals' performance.


BACKGROUND: Between January 2007 and December 2014 , we transplanted 143 patients (Pts) using RIC- conditioning allogeneic transplant. 71 were transplanted for acute leukemias (AML and ALL) and high risk myelodysplastic syndromes (MDS) not eligible for myeloablative transplantation. Clinicians are usually scared to transplant older patients with MUD because of the higher risk of Treatment-related mortality (TRM). We thus reviewed retrospectively the impact of donor / recipient ages and donor-choice (familial related donor (RD) versus matched unrelated donors (MUD)) on the post-transplant outcome of the pts. POPULATION AND METHODS: We retrospectively studied in our cohort of 71 leukemia pts evaluable after RIC transplant, the overall survival (OS) and event-free survival (EFS), according to recipient ages (≤ 54yo vs ≥55yo) and donor types (RD vs MUD). Conditioning consisted of combinations of Busulfan-Fludarabin-ATG or Endoxan-Fludarabine-ATG. Immunosuppression was a combination of cyclosporine (CSA)/mycofenolate mofetil (MMF), Tacrolimus (TAC)/ MMF or TAC/ Sirolimus. Chimerism analyses were performed on d30, d90 and d180. Both study-groups were well balanced concerning transplant conditioning regimens, (ATG or not) RD vs MUD donors, type of leukemia and status of the disease at transplant. Our local EBMT database was the source for this analysis. RESULTS: 34 de novo AML (20 ≤54 yr and 14 ≥55 yr), 30 secondary AML and MDS (15 ≤54 yr and 15 ≥55 yr) and 7 ALL (5 ≤54 yr and 2 ≥55 yr) were enrolled in our trial. 24 pts received HLA identical RD in the group ≤54yr and 14 pts in the group ≥55 yr. The others pts received MUD transplant from HLA 9 or 10/10 donors (16 in the group ≤ 54yr and 17 in the group ≥ 55yr). The median follow-up was 22 (3-93) months. Engraftment rate was 100% in the studied cohort. TRM before d100 was 18,3% (15% ≤54 yo and 22,6% ≥ 55yo). Grade II-IV Acute GVHD (aGVHD) at d90 (16,6%) and Chronic GVHD rates (24%) were similar in both age populations. 5 yrs OS was not different according to the age of the recipient (≤54 yr versus ≥55 yr)(p = 0.9). However, there is a clear, difference in 5years OS when stratifying the two age groups according to donor-types, especially for older patients (≥55 yr) with MUD transplant. (pts ≤ 54yr : OS: RD: 31,6%; and MUD: 38%; pts ≥ 55yr : OS: RD: 27,8% and MUD 44,2%). This trend in a better OS in older MUD pts could be explained partially by a lower relapse-rate in the group ≥ 55 yr with a MUD as shown by EFS/5yrs (pts ≤ 54 yr : RD: 32%; ≤ 54yr MUD: 19%; pts ≥ 55yr RD: 21% and ≥ 55yr MUD 38,5 %). As reported already in transplanted CLL patients, this suggests a greater GVHD/GVL-effect in the MUD transplantation. We then further investigated the age of the donors and its correlation with aGVHD and cGVHD. In the RD RIC transplant group, median age of the donors was 49 yrs (range 35-69 years) with 37.5% of aGVHD and 42% of cGVHD. In the MUD RIC transplant cohort, donor median age was 31 yrs (20-55 years) with 12% of aGVHD and 32% of cGVHD. We previously reported that the number of CD8+ T cells and naive CD4+ T cells decreases with the age of the donor, also supporting a better control of the disease with younger donors. This combination of younger donor age, lower aGVHD and a similar rate of cGVHD clearly explains the better outcome in pts transplanted with MUD. Our data requires confirmation in a larger series of patients. CONCLUSION: our observations confirm that: 1) RIC transplantation is a curative approach in acute leukemia whatever the age when the pts are fit enough to tolerate the transplant. 2) despite a higher TRM compared to younger patients, older patients seem to particularly benefit from MUD in terms of OS. 3) an increased EFS is observed in older pts transplanted with MUD (also younger) donors more likely due to a greater GVHD/GvL effect in the MUD setting. Disclosures No relevant conflicts of interest to declare.


Pamea guianensis Aublet and Terminalia nitidissima Rich. are, on the basis of recently collected material, recognized as hitherto overlooked species of Buchenavia Eichler, and the two new combinations are made.


Based on a winding cycle of filaments,a calculating model was proposed for the fiber orientation(including axial,radial and hoop orientation) of a unit cell of prefabricated piece of the multidirectional filament winding with focus on investigating the relationship between the fiber volume fraction of hoop orientation,fiber volume fraction of axial orientation and the process parameters such as the initial filament winding radius,the filament winding angle,and the fiber diameter.The curves of their relationship were plotted.The filament winding angle when the fiber volume fraction of hoop orientation was equal to that of axial orientation was calculated.This will provide a sound theoretical basis for the structural design and process design of prefabricated piece of multidirectional filament winding.


The under-representation of female athletes by print media has been widely acknowledged by feminist media scholars. However, there have been a number of recent studies which suggest that things are changing in terms of progress towards gender equality. In light of such studies this article examines the representation of sportswomen in five British Sunday newspapers, three broadsheets (The Sunday Times, The Observer and The Sunday Telegraph), and two tabloids (the Mail on Sunday and the Sunday Express), over a 24-month period (January 2008–December 2009). The results suggest that sportswomen are still overwhelmingly under-represented in British print media.


** The application of a Computational Fluid Dynamics tool to a jet flap control effector on an elliptical airfoil-section wing was investigated. The study utilized the Tetrahedral Unstructured Software System developed at NASA Langley Research Center. The Reynoldsaveraged Navier-Stokes flow solver code used was USM3D. The CFD-based jet flap simulations were compared to experimental results from a wind tunnel test conducted at the NASA Langley Transonic Dynamics Tunnel. The wind tunnel model consisted of a six percent thick elliptical airfoil with a modified trailing edge. The jet flap was located at 95% chord and exited at 90 degrees to the lower surface. The experimental model was designed to promote two-dimensional flow across the wing. It was found that the CFD simulation had to model the three-dimensional geometry of the experiment in order to obtain good agreement. Tests were performed at two Mach numbers at several different jet momentum coefficients. In order to be consistent with the experimental method, the CFD lift and pitching moment values were determined by integrating the pressures over the wing.


This work presents strategies adopted to solve what at the time was the largest production loss related to flow assurance in the company: the recurrent formation of hydrate blockages in flowlines of multiple wells of a FPSO in the Marlim oil field in Brazil.
 These blockages, which reoccurred frequently for various reasons, required a comprehensive plan for resolution. The main hydrate blockage cases were related to operational mistakes, problems in topside equipment, problems in subsea equipment and inaccurate procedures.
 In response to this challenge, a systematic approach was employed to identify and implement viable solutions. The key point of this work revolves around the same strategy - prevention - which was divided into three different courses of action: equipment, procedures and people.
 After implementing these processes, the results were exceedingly positive. That which was a recurrent problem became a steady state of zero production loss due to preventable hydrate blockages for 1.5 years, until the end of the FPSO unit's production life.


Drawing on my definition put forth in the Handbook of East Asian New Religious Movements (Pokorny and Winter 2018: 4–6), East Asia is taken to comprise China/Taiwan, the Koreas, Japan, and Vietnam. UFO religiosity here is not limited to the belief in aliens-cum-spacecraft but may also involve extraterrestrial entities in the absence of related vehicles and vice versa. This chapter is a first tour d'horizon of a subject hitherto not systematically researched by scholars of East Asian religions. Several movements of East Asian origin (Japan, China/ Taiwan, South Korea) are introduced with a focus on their ufological aspects. Particular emphasis is given to the Japanese context where UFO religiosity thus far has taken its most expressive form. East Asian ethnic UFO religiosity aside, a number of western UFO groups are visibly active in the region, such as most sizeably Scientology (operating branches in Japan: Saientorojī サイエントロジー, https://www.scientology .jp/; South Korea: Saiŏnt'ollojigyo 사이언톨로지교; Taiwan: Shāndájī Jiàohuì 山達基教會, https://www.scientology.org.tw/; and Vietnam: Khoa luận giáo) and Raelism (present in Japan: Raerian Mūbumento ラエリアンムーブメント, https://www.raelianjapan.jp/; South Korea: Raellian Mubŭmŏnt'ŭ 라엘리안 무브먼트, http://www.raelian.co.kr/; Taiwan: Léiěr Yùndòng 雷爾運動, https:// tw.rael.org/; and Vietnam: Phong trào Rael, https://vi.rael.org/) with both having several hundreds to thousands of adherents altogether. Smaller groups with local followings going into the dozens comprise, among others, Benjamin Creme's (1922–2016) Share International (Japan: Shea Intānashonaru シェア インターナショナル, http://www.sjsh.co.jp/; allegedly also being active in South Korea and Taiwan); Eduard Albert "Billy" Meier's (b. 1937) FIGU or Freie Interessengemeinschaft für Grenzund Geisteswissenschaften und Ufologiestudien (Japan: Figu Randesuguruppe Yāpan フィグ ランデスグルッペ ヤーパン, http://jp.figu.org/); and George King's (1919–1997) Aetherius Society (Japan: Aseriasu Sosaetī アセリアス・ソサエティー, https://www.aetherius.org/ jp/). The presence of these movements—and especially that of Raelism1—


Three biofertilizers (BF) and three plant strengtheners (PS) were tested in comparison
to chemical fertilizer application and BABA (DL-3-amino-n-butanoic acid), respectively
for their effects on the reactions of six different tomato varieties against three isolates
of Phytophthora infestans in detached leaf disk assays. All experiments were repeated
twice with six replicates each. Two of the BF (BioIlsa and Biofeed Quality) significantly
reduced late blight severity as compared to horn meal and chemical fertilizer with no
fertilizer by isolate and fertilizer by variety interactions. All PS significantly reduced
susceptibility of all tomato varieties. However, the interactions among PS, variety and
isolates were highly significant suggesting that different resistance mechanisms might
be affected by the PS and BABA. Preliminary results indicate that the combined
effects of PS and BF are additive without interactions.


Diagnoses are given for Fissidens gardneri Mitt. (syn.: F. brevinervis Broth., F. fouta- djalloni Par., and F. microcladus Thwaites & Mitt. in Mitt.) and F. minutus Thwaites & Mitt. in Mitt. (syn.: F. chungii ThOr., F. garberi Lesq. & James, and F. rizalensis Bartr.). Fissidens gardneri and F. minutus are examples of species with broad distribution in the neotropics, Asia, and Africa. Section Semilimbidium C. Mill. of subgenus Fis- sidens includes some of the most taxonomically dif- ficult species in the genus Fissidens Hedw. Although a plethora of names exists for the myriad expres- sions encountered in this principally tropical taxon, associating the correct name with the proper mor- phological expression has often been problematic. Four names, representing two closely related but distinct species, that have caused confusion are F. gardneri Mitt. and F. garberi Lesq. & James, and F. minutus Thwaites & Mitt. in Mitt. and F. mi- crocladus Thwaites & Mitt. in Mitt. In this paper diagnoses of F. gardneri and F. mi- nutus are given, and our understanding of the no- menclature, previous application of names, and dis- tribution of the species is presented. Both F. gardneri and F. minutus are further examples of species dis- tributed in the neotropics, Asia, and Africa (Pursell et al. 1992). Geographical regions given are accord- ing to Hollis and Brummitt (1992).


There are still debates in the scientific literature about the factors influencing countries' sustainable socioeconomic development. Therefore, the current article aims at determining the factors of sustainable socioeconomic development and assessing its level in the EU countries. The following methods were employed for the research: an evaluation based on distance from average solution (EDAS) and hierarchical cluster analysis (HCA). EDAS was used to reveal which countries have the highest level of sustainable socioeconomic development, and which have the lowest. The ranking was done based on the appraisal score, which is an outcome of EDAS. Hierarchical cluster analysis (HCA) was used for clustering the countries based on the appraisal scores in order to distinguish groups of countries having a similar level of sustainable socioeconomic development. The results revealed that the highest level of sustainable socioeconomic development is in Germany, and the lowest in Portugal. Based on HCA, the countries were divided into three groups. The first cluster's countries have the weakest sustainable socioeconomic development, and countries assigned to the third cluster have the best. In the current research, the third cluster consists of one country, Germany, which supports the results obtained with the EDAS method, i.e., Germany is the country with the highest level of sustainable socioeconomic development in the EU.


Aiming at the lack of interests with P.E.inferior student groups and difficulties in motivating them,the authors analyze the actuality and causes of this lack of interests among the P.E.inferior students,and propose some effective methods and countermeasures in dealing with these problems.


Abstract— In this paper we describe by a number of examples how to deduce one single characterizing higher order differ ential equation for output quantities of an analog circuit. In the linear case, we apply basic "symbolic" methods from linear algebra to the system of differential equations which is used to model the analog circuit. For nonlinear circuits andtheir corresponding nonlinear differential equations, we show how to employ computer algebra tools implemented in Maple, which a re based on differential algebra.


A simple model of the complex modulus, based on the general principles for a linear response function, is presented. The model represents a generalization of the Maxwell model and it is indicated that the model well describes a relatively broad group of regular and modified asphalts. A discrete spectrum of no more than 10 relaxation times is obtained for all the asphalts studied. The spectra of modified asphalts indicate the presence of several relaxation times that can be related to the interface interactions of the base asphalt and the polymers used. It is indicated that the phase angle of the complex modulus contains valuable information about the structure of asphalts. An attempt to use this information for calculations of the molecular mass distribution is presented. A possibility to characterize asphalts by the so-called pseudospectra is also discussed.


Minstrels, who express their emotions and thoughts accompanied by their saz (a stringed instrument) and are the single most important representatives of the oral tradition, serve as interpreters of the people among whom they are a part of as well as reflecting their spiritual values through improvised tunes and playing a significant role both as the carriers of language and culture. One of these minstrels was Âşık Şenlik of Çıldır, who held an important place within the Eastern Anatolian minstrel tradition. As a lover of his people, his tunes, which were the hallmark of the century in which he lived, were deeply themed around the social, political, and societal events of that period, and thus became etched both in the consciousness of the nation and its people alike. Most of his tunes were didactic in nature, and in addition to being rich in knowledge and meaning, they must separately be addressed in terms of reflecting the language of the people and the region he belonged to nevertheless. No minstrel cannot be thought separate from their lands, region, and the local people. Their tunes, in which they sing in improvisation with the entire body, therefore, carry the all of the dialectal richness of that region. This study examines the consonant harmonies found in poetries of the minstrel Şenlik, being a Karapapak/Terekeme Turk, which only carry tremendous resonance from the past into the present, but also hold significance from dialectal features. Upon classifying the phonetic qualities of these harmonies determined in his poems in detail, the status of these matters especially in some derivational affixes and inflections is given through various examples determined in his poetry.


The behavior of gold chloride (AuClx) encapsulated within the inner space of a single-wall carbon nanotube (SWCNT) was investigated under electron beam (e-beam) irradiation and high temperatures. Analysis of the pristine specimen by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and Raman spectroscopy show that AuClx is encapsulated within the SWCNTs as a dilute disordered structure. In situ TEM observation of the specimen under e-beam irradiation shows that, within the SWCNTs, AuClx is reduced to a crystalline Au nanowire (AuNW). The AuNW drifts significantly within the SWCNT during the reduction. At high temperatures (>673K), in situ TEM shows that the AuNWoscillates intermittently at a frequency of ³1.1s ¹1 and amplitude of ³60nm. Raman spectroscopy and EDX suggest that these phenomena are caused by an increase in the internal gas pressure in the SWCNTs because the decomposition of AuClx by ebeam irradiation or heat treatment produced chlorine (Cl2) gas. [doi:10.2320/matertrans.MD201308]


The utility model relates to a power-assisted door handle, which is characterized in that the handle is arranged into a lever structure, wherein the rotating pivot of the handle is the rotating shaft fixedly linked with the door body, the outer end of the handle is fixedly connected with a pulling lever, the inner end of the handle adopts an incomplete gear; a sliding ejection pin that can form a pushing effect to box is arranged at the door lateral, one end of the sliding ejection pin is pointed to the box, the other end adopts a gear rack structure, and the gear racks on the sliding ejection pin and the incomplete gear in the internal end of the handle form a meshing transmission by the gear and the gear racks. The power-assisted door handle is applied in the electrical equipment adopting magnetic gate seals to realize the power-assisted opening, thus to ensure the door opening to be easier.


Cardiac surgical patients are often discharged to a rehabilitation
facility to complete the convalescence in a protected setting. This care
pathway is usually reserved for elderly and fragile patients, with
severe and invalidating comorbid conditions. Between March and April
2020, nineteen patients were discharged from our unit to a
rehabilitation clinic where a hotbed of SARS-CoV-2 infection was
documented on April 17. After the outbreak, all patients underwent
screening with real-time PCR on nasal swabs, and 18/19 patients were
found positive. Diversely from other observations on perioperative
COVID-19 reporting mortality rates of 30-40%, the COVID-19 had a benign
course in our cohort: six patients were completely asymptomatic, and
only seven patients required hospitalization (no deaths). We describe
the baseline, operative and postoperative features of these patients,
and present some potential explanations for the surprisingly benign
course of the COVID-19 in this cohort.


Understanding the historical processes in the shaping of stage folk music
 raises an important question about the application of traditional music in
 stage choreographic works. Since the 1930s in Serbia, the history of music
 and dance was cre?ated by prominent individuals, musicians and composers,
 initiated by the work of choreographers such as Maga Magazinovic, Russian
 artists, and later by many domestic performing artists gathered around
 cultural and artistic societies and the National ensemble ?Kolo?. In this
 article, all available data relevant for the consideration of stage folk
 music as a specific genre will be presented along with the stage folk dance,
 precisely through the form of folk dance choreography (FDC), whose
 developmental path was hinted at since the end of the 19th century.
 Defining and understanding dance music, that is, music for FDC, opens new
 horizons in re-examining the process of forming stage folk music in our
 region.


The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways. In contrast, the class II mutations frequently involve transcriptional regulators of normal hematopoietic differentiation, and result in a block of hematopoietic cell maturation and/or aberrant self-renewal capacity. However, expression of the class II mutations in the murine hematopoietic system often leads to myelodysplasic changes and acute leukemia after a long latency, suggesting that collaboration of additional genetic alterations might be required.

To identify potential cooperating genetic events facilitating induction of acute leukemia by the class II mutations, we modeled acute myelogenous leukemia (AML) in mouse by retrovirally expressing the MLL/ENL and MOZ/TIF2 fusion genes in the bone marrow. The genetic background of leukemic mice (F1 hybrid mice resulting from crossbreeding the FVB/N and 129/s1 strains) allowed us to perform a genomewide polymorphism analysis screening for loss of heterozygosity (LOH) that is frequently found in blasts from AML patients. However, a simple sequence length polymorphism (SSLP) based allelotyping as well as a mouse 5K single nucleotide polymorphism (SNP) array analysis did not showed any LOH, indicating that large scale of LOH might be a rare event in our mouse leukemia models.

Recent studies have shown that genomic insertion of retrovirus could influence the expression of adjacent genes and therefore contribute to oncogenic transformation of hematopoietic cells. The retroviral integration tagging approach has been widely used for seeking new proto-oncogenes or tumor suppressor genes, and especially for identifying collaborative events in tumor models that already harbored an initiating oncogenic event. To test the hypothesis that the integration of the provirus could act as cooperating events in our mouse leukemia models, we characterized the retroviral integration sites from 21 leukemic mice induced by retroviral expression of MLL/ENL and MOZ/TIF2 fusion genes. Sixty-six integration flanking genes were identified, and most of them have been previously linked to tumorigenesis. Further determination of their expression levels demonstrated that integration flanking genes like Tcf7, Tnfrsf1, Mn1 and Lhx2 were up-regulated, whereas Pur , Ppp2r5c, Runx3, Socs1 and Prdm2 were down-regulated. Interestingly, in a MLL/ENL leukemic mouse carrying the integration adjacent to the meningioma 1 (Mn1) gene, the clone harboring the Mn1 integration prevailed over other co-existing clones harboring different integrations. Moreover, an in vitro cellular proliferation assay showed that the overexpression of MN1 significantly enhanced proliferation and self-renewal capacity of primary bone marrow cells. These findings suggested that MN1 possesses leukemic transforming potential and might functionally collaborate with the MLL/ENL fusion in the development of the acute leukemia. In order to experimentally address this hypothesis, we performed a series of bone marrow transplant experiments. Indeed, co-expression of MN1 with MLL/ENL enhanced in vivo disease development, and resulted in a significantly reduced latency for induction of an aggressive acute leukemia than expression of MN1 or MLL/ENL alone. In addition, co-expression of MN1 increased the granulocytemacrophage progenitor (GMP) cell population expressing Gr1/Mac1, Cd34 and c-Kit with leukemia-initiating properties as shown in secondary transplantation experiments. As MN1 has been previously proposed to exert its function as a transcriptional co-activator, we also aimed to identify the potential downstream target genes by transient MN1 expression in primary bone marrow cells. Gene expression profiling experiments revealed a series of genes with known roles in normal or malignant hematopoiesis such as CD34, FLT3, HLF, and DLK1 that were upregulated in MN1 overexpressing murine leukemias, as well as pediatric acute leukemias with high MN1 levels. We also determined the MN1 levels in a large panel of pediatric acute leukemias. High MN1 expression levels were observed in 50 of 87 samples: high MN1 levels were found in a large proportion of B-cell ALL cases and in most infant leukemias that carry MLL fusions and are of B-cell origin. Additionally, siRNA-mediated MN1 knockdown resulted in cell cycle arrest and impaired clonogenic growth of human leukemia cell lines with high MN1 levels but not in cells with low (or undetectable) MN1 levels, suggesting the aberrant expression of MN1 contributes to malignant cellular proliferation, and the inhibition of MN1 could represent a new therapeutic approach. Taken together, while searching for cooperative genetic alterations in murine leukemias, we found that elevated levels of MN1 oncogene can act as a functional collaborator in MLL/ENL (and probably other class II mutations) induced leukemia through a distinct genetic program that increases the leukemia stem cell pool. In addition, we also demonstrated for the first time that high MN1 levels are found in a significant fraction of childhood acute leukemias, and important for proliferation of the leukemic cells.


A rapid formation of Chlamydomonas bloom was observed in a pond of Wuhan park from Feb.2000 to Mar. 2000. Several factors and their influence on the occurrence of the bloom were studied. The result indicated that ammonium and phosphate were the main factors that influenced the growth of chlamydomonas: the bloom began to occur as the ratio of ammonium and phosphate was 17, and the bloom rapidly regarded when the phosphate deduced to 0.065 mg/L. And also we found out that the degradation of the bloom was related to some biology factors, such as bacteria, lemna minor and zooplankton.


terminal ileitis, without pathologic findings in the supramesocolic organs. Four blood cultures were taken, immunosuppression therapy was withdrawn, an exclusive enteral feeding with a polymeric formula and empirical antibiotic therapy with cefotaxime 2 g/ 8 h were established. After 48 hours he continued with spiking fever and developed right upper quadrant tenderness with enlarged liver. Liver function test had slightly worsened with ASAT 93 U/L, ALAT 88 U/L and bilirubin 2.01 mg/dL. C-reactive protein and procalcitonin were, respectively, 185.1 mg/L and 20.7 ng/mL. White cell count was 4,550/ mL (3,820 neutrophils). Right upper quadrant ultrasonography scan revealed a thickened gallbladder wall, with a layered appearance, and a small amount of fluid on the base with an echoic content without shadow. He was diagnosed of acute acalculous cholecystitis, and antibiotic was changed to piperacillin-tazobactam 4 g/ 8 h. The hepatomegaly and the right Sir,


William Dale Archerd, also known as James LynnArden and by other pseudonyms, was foundguilty on 15 March 1968 of murdering his nephewand two of his seven wives. These were probablynot the only killings he committed. He was then55 years old and had a varied past as salesman,erstwhile mental hospital attendant and serialmatrimonialist. His wives had a habit of dying,and William had chosen insulin as the weapon tokill two, and possibly three, of them as well as hisother victims. He presumably stole it, as for muchof the time he was unemployed, but he could alsohaveboughtitoverthecounterasinsulinwasnotaprescription-only drug and was freely available.Although his murderous career really began in1947, it was only 20 years later, when he wasarraigned for murder, that his earlier crimes cameto light.William had, it seemed, always wanted to be adoctor but, not having the opportunity or – poss-ibly the ability – to pursue this career, spent sometime during the early 1940s working as an orderlyinastatementalhospital–andthenext25yearsina life of crime.In 1950 some of his earlier misdemeanourscaught up with him and he was sentenced to fiveyears' probation after pleading guilty to illegalpossession of morphine. The probation wasrevokedafterhecommittedaseconddrugoffence.He was sent to a minimum-security prison, fromwhich he escaped in 1951.Afterrecapturehewassenttothehigh-security,andhighlynotorious,SanQuentinjail,fromwhichhewasreleasedonparolein1953.SanQuentinhadbeen established in 1852 at Point Quentin, anislandoffMarinCountyinSanFranciscobay,asananswertotherampantlawlessnessinCaliforniaatthattime.California'sonlygaschamberanddeathrow for all condemned male inmates were locatedat San Quentin and it was possibly there thatWilliam was launched into serious crime.The story begins when William contacted thepolice on 24 July 1956 to report an alleged robberyat his home in Los Angeles. He said that tworobbers had come to his home, armed with gunsand hypodermic syringes, which they had used toinject both him and his current (third) wife, Zella,in the buttocks. They made off with $500 but noneof Zella's jewellery, which was on full view in herbedroom. At the scene of the crime the policeinitially found two puncture wounds in Zella'sbuttocks (later amended to four after examinationof photographs taken of her after death), but nonein William's.Zella was dizzy but not comatose when thepolice arrived, and she corroborated her hus-band's statement about the robbers, although shenever saw them, as they put a pillowcase over herhead.Afterthepoliceleftshegraduallylapsedintocoma and had convulsions, from which she diednext day without regaining consciousness. Duringa search of the house and surroundings the policefound a hypodermic needle in a bathroom drawerand a half-used vial of long-acting insulin in anearby field.The investigating police officer in Los Angeles,Sergeant Harry Andre, drew the coroner's atten-tion to the insulin vial. However, because no poi-sonous substances were found in Zella's body andnomethodofmeasuringinsulinwasreadilyavail-able except in research laboratories, he had noevidencethatshehaddiedfrominsulinpoisoning.Zella's death was officially attributed to broncho-pneumonia, but suspicion remained, at least inSergeant Andre's mind, that she might have beenmurdered.TheseconddeathtocometotheattentionoftheauthoritieswasthatofJuanita,William'sfifthwife.She and William lived in Las Vegas, Nevada,where William had gone to live soon afterZella's death. Juanita was discovered in a comaon 12 March 1958, only two days after she and


The SHARP (Scottish Health, Housing and Regeneration Research Project) study was carried out to investigate the links
between housing and regeneration, and health and well-being. It involved interviewing a national sample of social sector
tenants who were rehoused into newly built, general purpose housing developed and let by Registered Social Landlords
across Scotland (the Intervention Group). Participants were interviewed before they moved, and again 2 years after they
moved. Data were also collected by postal survey one year after the move, and in-depth qualitative interviews were conducted
at 2 points in time. The tenants who moved were compared to a Control Group of people living in the same area as the new
house, but who were not themselves due to be rehoused from their existing home. Data were collected on housing and
neighbourhood conditions, physical and mental health, use of health and other services, and a range of social and community
outcomes, including community cohesion. SHARP also examined whether rehousing within a regeneration area (Social
Inclusion Partnership) provided additional residential or health gains.


Vertical geometry Ni/Au-β-Ga2O3 Schottky rectifiers were fabricated on Hydride Vapor Phase Epitaxy layers on conducting bulk substrates, and the rectifying forward and reverse current-voltage characteristics were measured at temperatures in the range of 25–100 °C. The reverse breakdown voltage (VBR) of these β-Ga2O3 rectifiers without edge termination was a function of the diode diameter, being in the range of 920–1016 V (average value from 25 diodes was 975 ± 40 V, with 10 of the diodes over 1 kV) for diameters of 105 μm and consistently 810 V (810 ± 3 V for 22 diodes) for a diameter of 210 μm. The Schottky barrier height decreased from 1.1 at 25 °C to 0.94 at 100 °C, while the ideality factor increased from 1.08 to 1.28 over the same range. The figure-of-merit (VBR2/Ron), where Ron is the on-state resistance (∼6.7 mΩ cm2), was approximately 154.07 MW·cm−2 for the 105 μm diameter diodes. The reverse recovery time was 26 ns for switching from +5 V to −5 V. These results represent another impressive advanc...


Abstract A novel continuously variable transmission (CVT) mechanism (a shaft-drive CVT) was developed by the present authors. In the mechanism, the input and output shafts with conical disks are parallel and an idler shaft with conical rollers at both ends is placed perpendicular to the input—output shafts. This idler shaft transmits torque from the input shaft to the output shaft and its linear motion causes the speed to vary by changing the contact point between the input—output disks and the idler roller. In this paper, the use of a disk with a concave shape is proposed in order to decrease the amount of spin caused by the change in the contact point, because the spin has an adverse effect on traction contact performance and is responsible for an increase in power loss. The design procedure of the novel concave disk and the roller is discussed and their effect is evaluated using a prototype CVT. The speed efficiency was improved to 1.6 points in the case of a transmitted power of 0.6kW.


This paper examines the dynamics of the representation of the "sea woman," sometimes known as Sedna, among the Inuit of Northeastern Canada in myths, shamanic experiences, and modern artistic representations. The varying representations of the sea women are connected to shamanic practice. The sea woman does not have a clearly defined iconography; this lack of definition gave shamans some flexibility in giving versions of encounters with the sea women, and enables Inuit artists to utilize that lack of iconographic specificity in creating their sculptures today.


During the last decade the European activities in the field of nuclear fission research include the design of fast reactors cooled by liquid metals. Within this framework, the Fast REactor NEutronics/Thermal‐hydraulICs (FRENETIC) code is being developed at Politecnico di Torino over the last few years. It implements a full‐core coupled neutronic/thermal‐hydraulic model of a liquid‐metal‐cooled fast reactor as relevant for two of the six options currently under study within the framework of the Generation‐IV International Forum, namely the lead‐cooled fast reactors and the sodium‐cooled fast reactors. The code validation process involves the participation in a coordinated research project of the International Atomic Energy Agency, aiming at testing different computational tools against the shutdown heat removal tests performed many years ago in the sodium‐cooled Experimental Breeder Reactor‐II (EBR‐II) at Argonne National Laboratory, USA. In this paper, results of the FRENETIC analysis of one of the transients considered in the project, the unprotected EBR‐II shutdown heat removal test SHRT‐45R, are presented and compared to the measurements, providing the first validation of the coupled neutronic/thermal‐hydraulic features of the FRENETIC code. Copyright © 2016 John Wiley & Sons, Ltd.


Laser-driven ion acceleration can provide ultra-short, high-charge, low-emittance beams. Although undergoing extensive research, demonstrated maximum energies for laser-ion sources are non-relativistic, complicating injection into high-$\beta$ accelerator elements and stopping short of desirable energies for pivotal applications, such as proton tumor therapy. In this work, we decouple the efforts towards relativistic beam energies from a single laser-plasma source via a proof-of-principle concept, boosting the beam into this regime through only a few plasma stages. We employ full 3D particle-in-cell simulations to demonstrate the capability for capture of high-charge beams as produced by laser-driven sources, where both source and booster stages utilize readily available laser pulse parameters.


The Habo deposit is a typical porphyry Cu‐Mo deposit in the Ailaoshan–Red River metallogenic belt. Ore minerals in the Habo deposit typically occur as veins in the monzonite porphyry. Zircon U‐Pb dating suggests that the monzonite porphyry formed at 35.07 ± 0.38 Ma. The monzonite porphyry is characterized by high SiO2, Al2O3, K2O and Na2O contents, with A/CNK ratios ranging from 0.97 to 1.02. All samples exhibit fractionated REE patterns, characterized by high (La/Yb)N ratios (9.4–13.6, average of 11.2). They show adakite‐like geochemical features, high Sr concentrations (627–751 ppm, average of 700 ppm), low Y concentrations (15.13–16.86 ppm, average of 15.81 ppm) and high Sr/Y values (39.5–47.4, average of 44.3). These samples have high initial 87Sr/86Sr ratios (0.7074–0.7076) and negative εNd(t) values (–5.1 to −3.7), whereas the zircon εHf(t) values range from −2.2 to +0.4, suggesting that the monzonite porphyry was derived from the partial melting of a thickened juvenile lower crust. The oxygen fugacity, calculated on the basis of the chemical composition of the amphiboles, shows ΔNNO values ranging from +1.65 to +2.16 (average of 1.94) and lg(fO2) ranging from −12.72 to −11.99 (average of −12.25), indicating that the monzonite porphyry has high oxygen fugacity. Zircons have high Ce4+/Ce3+ ratios (29.29–164.24, average of 84.92), with high ΔFMQ values ranging from +0.50 to +1.51 (average of 0.87) and high lg(fO2) values ranging from −14.72 to −12.85 (average of −14.07), which also indicates that the oxygen fugacity of the magma was high. The dissolved water content of the Habo monzonite porphyry is 9.5–11.5 wt%, according to the geochemical characteristics, zircon‐saturation thermometry (692–794°C) and the mineral phases (amphibole, no plagioclase) in the deep magma chamber. Combined with previous studies, we propose that the high oxygen fugacity and high water content of magma played key roles in controlling the formation of the Habo and other Cu‐Mo‐Au deposits in the Ailaoshan–Red River metallogenic belt.


Technology teachers' professional training intensification affairs are examined in this article, intensification problem theoretical and applied essence and approaches to researching it revealed.


This paper presents the simulation of the nonlinear dynamic response of a full‐scale seven‐story reinforced concrete shear wall shaking table specimen under base excitations representing four earthquake records of increasing intensity. The study was motivated by the participation in the blind prediction contest of the shaking table specimen organized by University of California at San Diego (UCSD), NEES, and Portland Cement Association (PCA). Owing to the time constraints of the contest a relatively simple two‐dimensional (2d) model was used for the shear wall specimen. In this model, the shear wall was represented by 2d beam–column elements with fiber discretization of the cross‐section that account for the interaction of the axial force with the bending moment. Upon conclusion of the contest, the available experimental measurements permitted a thorough examination of the analytical results. While the measured data confirmed the excellent accuracy of the model predictions, some limitations also became apparent. The paper addresses the benefits and limitations of the selected modeling strategy and investigates the sensitivity of this type of model to parameter selection. Copyright © 2009 John Wiley & Sons, Ltd.


The lime sludge from pulp and paper industry was thermo-chemically activated at 850 oC in the presence of alkali. The lime reactivity of activated sludge was evaluated (as per IS: 1727) in terms of compressive strength (varies from 3.61 MPa to 4.36 MPa) for its use with Portland cement clinker. Various mixes comprising of cement clinker, fly ash, calcined clay and ground granulated blast furnace slag (GGBFS) and thermo-chemically activated lime sludge were formulated. The Blaine's surface area and particle size distribution of the resulting mixes was found in the range of 500 m2/kg -561 m2/kg and 1.678 x 10-5 m to 4.177 x 10-5 m, which are finer than Portland cement (285 m2/kg Blaine's surface area). All the mixes exhibited lime absorption value below the saturation line in lime solubility curve plotted between calcium oxide concentration and hydroxyl ion concentration showing their adequate pozzolanicity. Hydration behaviour of various mixes were studied with the help of isothermal conduction calorimetry. It was found that total heat of lime sludge binders were higher than the Portland cement. Addition of activated lime sludge into mix resulted intense acceleration peak indicated the possibility of higher strength development than the Portland cement in the hardened pastes. The binders were also tested for setting time and compressive strength by preparing the mortars. Based on findings of all these tests, it is concluded that cementitious binder containing GGBFS, calcined clay and 15% thermo-chemically activated lime sludge gives optimum results. Life cycle analysis of lime sludge based binder was carried out using SIMA PRO software. It was observed that global warming in terms of CO2 emission was reduced by 51% when compared with the Portland cement.


In the present work, engineering decisions for combined ground-fault relay protection in 6–10 kV power grids are addressed. For objects in electrical grids having a voltage of 6–10 kV, simple relay protection was used: overcurrent protection and current cutoff. The most common algorithms for single phase-to-earth fault relay protection were analysed and compared. The modelling allowed a scheme for automatic transfer switch to be designed. Operation algorithms of relay protection and automatics were established, considering the properties of an electrical grids section and the characteristics of possible operating conditions. In 6–10 kV electrical grids, an increase in the damage rate of cable lines with outdated thinned insulation was revealed. It was determined that long-term grid operation under a single phase-to-earth fault should be avoided since double earth faults may occur due to an increase in the voltage of healthy phases relative to earth by √3 times. The calculations performed to evaluate selectivity and sensitivity of the current protection of selective zero-sequence showed limited application (due to the insufficient sensitivity) of such protection from single phase-to-earth fault in some cases. The advantages of circuit designs, which use electromagnetic and inductive relays as protection fault detectors, and advanced compact elements in the form of microcircuits with electronic interconnection as logical elements, were investigated. It is established that the proposed solutions can be used by energy providers to increase the reliability and fail-safety of 6–10 kV distribution networks with the minimum capital expenditures to relaying systems. The presented analysis of systems and devices for phase-to-earth fault relay protection showed that power grids having isolated neutrals are the most problematic in terms of maintenance. Simplified circuit designs for combined protection circuits can be used for facilitating the maintenance of relaying devices and automatics due to their openness.


cussed. As an illustration of these concepts, a study is reported of 56 white, middle-class infants, 49-51 weeks of age, in a strange situation. The presence of the mother was found to encourage exploratory behavior, her absence to depress exploration and to heighten attachment behaviors. In separation episodes such behaviors as crying and search increased. In reunion episodes proximity-seeking and contact-maintaining behaviors were heightened. In a substantial proportion of Ss, contact-resisting behaviors were also heightened in the reunion episodes, usually in conjunction with contactmaintaining behaviors, thus suggesting ambivalence. Some Ss also displayed proximity-avoiding behavior in relation to the mother in the reunion episodes. These findings are discussed in the context of relevant observational, clinical, and experimental studies of human and nonhuman primates, including studies of mother-child separation. In conclusion, it is urged that the concepts of attachment and attachment behavior be kept broad enough to comprehend the spectrum of the findings of this range of studies.


"Nonrehabilitable sick!" Aren't these the ones who "need" an advance directive? Rep. Earl Blumenauer should explain what he means concerning end-of-life planning to be part of Medicare as being "a step in the right direction."


Propose continuation of the article published in the previous issue, devoted to archaeological studies of medieval Christian burial sites on the territory of the Halych-Volynian lands, conducted before 1939. Due to the fact that the indicated areas were at different times under the authority of different states, where archaeological studies of burial sites took place, accumulation of materials and their publication, etc. were conducted, several periods of research were distinguished. It is noted that changes on the political map of the world took place once again with the beginning of the Second World War and were associated with the formation of a new Polish-Soviet border in 1939, and later in 1945, as a result of which the former Halych-Volynian lands became part of Poland and the Ukrainian SSR. The last exchange of territories was observed in 1951. It was these boundaries of the Polish-Ukrainian border that were approved with the declaration of Ukraine's independence in 1991, and they remain unchanged to present.
In this regard, the studies conducted in Ukraine and Poland are separately characterized. At the same time, two periods are distinguished within the first period: 1939–1991 (Soviet) and 1991–present (Ukrainian). Research on the territory of Poland is outlined in the period from 1939 to the present.
It was established that the researches that took place as part of the Ukrainian SSR (third period) continued the tradition of studying medieval temple architecture, as well as the burials located in the complex, however, a significant number of necropolises were discovered accidentally. It was observed that the information about them is quite generalized, and this is connected both with the tasks that scientists set before themselves, and with the state of the research methodology at that time. Significant progress in the development of the latter has been observed only since the 1970s, however, despite the individual cases of involving anthropologists in the process of studying burial monuments, this practice was more the exception than the rule. However, during this time, a significant source base was accumulated, which, in combination with the materials of previous studies, made it possible to carry out the first general studies devoted to the burials of the IX–XIII centuries. It was established that some of the materials were exported from Ukraine.
It is noted that with the declaration of Ukraine's independence, a new period (fourth) began in the study of the researched issues, in the end, as well as the scientific tradition in general. Only Ukrainian scientists obtained the right to conduct archaeological research, and excavation materials stopped being exported to the Union republics. During this period, a further progression of excavation techniques and fixation of the discovered sites was noted. It has been observed that anthropologists are increasingly involved in research; there is a rethinking of approaches to the study of burials in general; more and more general works devoted to this issue appear, and the sights themselves are increasingly becoming the object of research.
It has been established that excavations carried out on the territory of Poland, which in the post-war period was included in the list of countries of the social camp and remained a satellite of the USSR until 1989, are marked by an in-depth study of the ethnogenesis of the Slavs and monuments of the princely era on the Polish-Rus border. This caused concern among Polish scientists about a possible border change in favour of the USSR in the future. Then and in the following decades, a number of burial sites were opened. The qualitative methodical level and the selection of anthropological material for analysis since at least the 50s of the 20th century have been identified as a feature of the conducted research. It is emphasized that during the last decade, professional analysis of the previously accumulated material, its verification, generalization and publication has been carried out, and in addition, a number of new monuments have been opened. It is noted that in conditions of sufficient funding, the study of burial monuments takes place on the basis of interdisciplinarity.
Key words: history of research, archaeology, burials, Christianity, the Middle Ages, Rus'


The invention relates to a three-dimensional object measurement system (1) having a stripe projector (2) for producing a strip-shaped light pattern on an object to be measured (3), wherein the stripe projector (2) a light source (4) and a liquid crystal light modulator (5) with a matrix-like arrangement of light and dark pixels includes controllable, and with an electronic camera (6) for recording images of the illuminated with the light patterns object (3). In order to achieve high measurement accuracy, the invention proposes that the stripe projector (2) and the electronic camera (6) by means of a control circuit (8) are actuated, that is configured such that, during an image exposure time, the pixels of the light modulator (5) be switched between light and dark, with the timing of the switching of the pixels is synchronized with the image acquisition.


We study the problem of resilient average consensus for multi-agent systems with misbehaving nodes. To protect consensus valuefrom being influenced by misbehaving nodes, we address this problem by detecting misbehaviors, mitigating the corresponding adverse impact and achieving the resilient average consensus. In this paper, general types of misbehaviors are considered,including deception attacks, accidental faults and link failures. We characterize the adverse impact of misbehaving nodes in a distributed manner via two-hop communication information and develop a deterministic detection-compensation-based consensus (D-DCC) algorithm with a decaying fault-tolerant error bound. Considering scenarios where information sets are intermittently available due to link failures, a stochastic extension named stochastic detection-compensation-based consensus(S-DCC) algorithm is proposed. We prove that D-DCC and S-DCC allow nodes to asymptotically achieve resilient averageconsensus exactly and in expectation, respectively. Then, the Wasserstein distance is introduced to analyze the accuracy ofS-DCC. Finally, extensive simulations are conducted to verify the effectiveness of the proposed algorithm


Objective: Establish biochemistry reference intervals suitable for the Laboratory center of Hanoi University of Public Health. Methods: The study was carried out based on guidance of CLSI EP28-A3 using indirect sampling method. 8345 normal sample from January 2018 to April 2021 in Laboratory center of Hanoi University of Public Health is used. Results: The results showed that the biochemistry reference intervals was established as below: GLU (3.94-6.38 mmol/L), men (3.94-6.48 mmol/L), women (3.95-6.26mmol/L); CHOL (3.46- 6.06 mmol/L), male (3.55-6.10 mmol/L), female (3.44-6.02 mmol/L); TRI (0.46-2.20 mmol/L), male (0.56-2.24 mmol/L), female (0.44-2.11 mmol/L); URE (2.62-7.10 mmol/L), men (2.93-7.32mmol/L), women (2.48-6.72mmol/L); CRE (53.62-107.09 µmol/L), men (68.58-111.14 µmol/L ), women (50.35-86.54 mol/L); AST (13.46-32.27 U/L, men (14.05- 32.83U/L), female (13.03-30.99 U/L); ALT (7.21-34.14 U/L), men (7,91-35,06 U/L), female (13,03-30,99 U/L). Conclusions: The reference intervals determined in our research have the significant differences to the reference intervals currently used in our laboratory. Key words: Reference interval, Laboratory Center, Hanoi University of Public Health


We describe an implementation of Doppler broadening thermometry based upon a room-temperature continuous-wave quantum cascade laser at 9.07 μ m, coherently phase locked to a thulium optical frequency comb centered at 2 μ m. The thermodynamic temperature is retrieved from the analysis of multiple-line absorption spectra of the NH 3 ν 2 band, adopting semiclassical line-shape models and taking into full account the speed dependence of collisional broadening. We demonstrate that a precision of approximately five parts over 10 5 can be reached as a result of the analysis of only 90 absorption spectra, as acquired as a function of the gas pressure.


This study aims to investigate the influence funding decisions , dividend policy and growth value manufacturing company in Indonesia Stock Exchange 2013-2014 period . This study used a sample of companies listed on the Stock Exchange in the period 2013-2014 , the sampling method used is purposive sampling with the number of respondent companies as much as 46. They study use multiple linear regression analysis . To test the hypotheses results showed the funding decision , dividend policy of the company 's growth did not significantly affect the value of a manufacturing company.


If one day the Hague Court were to decide to continue its work under US pressure and without Iran's presence, that day the United States would face our decisive and revolutionary response by every possible means. After all its disgraceful defeat and failure in Iran, the United States should have learned that the Islamic Republic is prepared to go as far as necessary in order to obtain its rights. It is really surprising that the United States has forgotten the episode of the occupation of the nest of spies so soon and forces the Hague Court to play dangerous games.[1][1]

It seems at times that there is no connection between the great political world and the Tribunal claims. We hear about the political rhetoric, but for commercial reasons Iran still wants to settle some of the claims. In some cases they need spare parts for machines that they want to get running again. A lot of goods and services also are provided to Iran by foreign affiliates and subsidiaries of US companies.[2][2]

 [1]: #fn-1
 [2]: #fn-2


This geophysical study was carried out in the city of Eseka, the head quarter of Nyong and Kelle Division, Center Region of Cameroon. It had as aims to prospect aquifers and to propose models of geophysical structures of the underground basement in the city. To this effect, the geophysical method of electrical resistivity was chosen, due to the local geologic context, and its easy application. With the aid of a resistivitimeter of mark TERRAMETER ABEM SAS 300, twenty (20) electrical soundings were effectuated in different points in the city. The treatment of data was done through several interpretation software, such as Geo-Elect. Mod and surfer8.0. Qualitative and quantitative interpretations, coupled with field and laboratory observations, permitted: the characterization of the lateritic crust constituted of the model of the terrain, into four and five layers of distinct terrain by their resistivity and thicknesses; the definition of the average depth of the upper aquifer from about three (03) meter in the loose clayey level, and the lower aquifer at about thirty (30) meter in the weathering and fractured gneiss level; the localization of the zone of conduction and resistant anomaly, at chosen depths in the study area. These results are important in future modeling process of the aquifers in this area.


The proportionate normalized least-mean-squares (PNLMS) algorithm is commonly used in acoustic echo cancellation (AEC) context. It provides faster initial convergence and tracking rates compared to the NLMS algorithm for the case of sparse echo impulse responses. The improved PNLMS algorithm (IPNLMS) has been proven to be more powerful than PNLMS by exploiting new rules for computing the weight of each step-size corresponding to each adaptive filter coefficient. However, the application of the PNLMS and the IPNLMS algorithms for adaptive feedback control (AFC) in hearing aids (HAs) is still limited due to high correlation between the loudspeaker and incoming signals. This paper proposes implementations of the PNLMS/IPNLMS algorithms for AFC using the prediction error method (PEM) for hearing aids. The proposed methods have been evaluated for both speech and music incoming signals. Simulation shows that the proposed methods have faster initial convergence and tracking than the PEM using the NLMS algorithm (PEM-NLMS).


Reverend Kim Jae-Joon, one of the founding members of Hanshin University, translated the Book of Genesis (chapters one through four) into Korean from the Hebrew original in the years of 1937 and 1938. His translation was published four times in a row in a Korean journal called "The Crusade", which is named Ship-Jah-Goon(십자군, 十字軍) in Korean. It was distributed in Yong-Jung (용정, 龍井) which is located in the north-eastern part of Manchuria, China. In those years he served as a junior high school teacher there. At the same time he was working as the chief editor of the periodical mentioned above. Some characteristics of his translation can be summarized as follows: (1) His translation of Genesis, though partly translated, is easy to read compared to the Korean Revised Version, which was released in the same year or so. (2) It seems to be the first Korean translation of the Bible that adopts "Yah-weh" instead of "Jehovah" or "Yehowah", which is publically accepted by the Korean Protestant Church. (3) He tried to deliver the Hebrew pun in Genesis 2:23(""ish" and ""isha") with transliteration because translating them cannot deliver its impact. (4) The Hebrew Masorectic text is rendered as literally as possible. For example, Genesis 2:4b in original Hebrew reads: "In the day Yahweh God created earth and heaven." The word order of the sentence is held in his translation. The most important thing is that the Hebrew ""adam" is thoroughly translated as "human" in Genesis chapter 2, contrary to other Korean translations such as the Old Version and Revised Version. (5) Hebrew idioms are translated into natural Korean. Genesis 4:5 reads "and it was kindled to Cain", while it is read in Korean, "Cain was very angry" or so. (6) The scholarly finding from textual criticism is reflected in his translation. For example, the Massorectic Genesis 4:8 does not have "Let us go out to field." But old translations such as the Old Latin version, the Syriac translation like Peshitta, and the recension of the Samaritan Pentateuch do. This explanation is added to his translation in parenthesis. (7) The most updated scholarly opinion concerning Genesis 1:1 is reflected in his translation. It is taken as a circumstantial phrase so that he reads it as follows: "In the beginning when God created heaven and earth." (8) Faithful transliteration of proper nouns to original Hebrew appears here and there. Compared to the Old Version in Korean (1911), his translation shows closer affinity to the original pronunciation. (9) Nevertheless, it seems that his translation of Genesis follows the Old Version in Korean (1911), more specifically in its ending style. (10) Korean orthography of his time those days frequently appears in his Genesis translation. Such examples are "Bae-ahm"(배암) for "Baem"(뱀, snake) and "Ahn-hae"(안해) for "Ah-nae"(아내, wife). (11) It has proper expressions used in the north-eastern part of Korean peninsula at the time.


Restrictive cardiomyopathy (RCM) is a myocardial disorder that usually results from increased myocardial stiffness that leads to impaired ventricular filling. Biventricular chamber size and systolic function are usually normal or nearnormal until later stages of the disease. Affecting either or both ventricles, RCM may cause signs or symptoms of left or right heart failure. Arrhythmias and conduction disturbances are frequently encountered. RCM may result from inherited or acquired predispositions and disease or a combination thereof, which broadly can be classified as infiltrative, storage disease, noninfiltrative, and endomyocardial (Table 1). Because of the heterogenous nature of the origins and manifestations of the RCMs and the concomitant challenges in diagnosing these diseases, it is difficult to accurately estimate the incidence and prevalence of any of the RCMs. Based on the current evidence, RCM is the least common of the cardiomyopathies. There are regional differences among the prevalence of RCM according to the cause. For example, endomyocardial fibrosis is primarily seen in the tropics and sub-Saharan Africa, whereas cardiac amyloidosis (CA) is more commonly diagnosed in other regions. Most causes of RCM are acquired. However, mapping several gene mutations as a cause of RCM have been recognized. These include mutations in the sarcomere subunits, such as troponin T (TNNT2 gene), troponin I (TNNI3), α-actin (ACTC), and β-myosin heavy chain Cardiomyopathy Compendium


The growing prevalence of obesity among adults and children has prompted legal initiatives designed to combat this public health problem. The authors describe litigation and legislation that target obesity and discuss the potential for public health law to reduce obesity in the United States.


The modern microprocessor is among the world's most complex systems, but at its heart is a very simple, and we think beautiful, device: the transistor. There are billions of them in a microprocessor today, and they are nearly all identical. So improving the performance and boosting the density of these transistors is the most straightforward way to make microprocessors — and the computers they power — work better.


Although canonical models of clientelism argue that brokers use dense social networks to monitor and enforce vote buying, recent evidence suggests that brokers can instead target intrinsically reciprocal voters and reduce the need for active monitoring and enforcement. Combining a trove of survey data on brokers and voters in the Philippines with an experiment-based measure of reciprocity, and relying on local naming conventions to build social networks, we demonstrate that brokers employ both strategies conditional on the underlying social network structure. We show that brokers are chosen for their central position in networks and are knowledgeable about voters, including their reciprocity levels. We then show that, where village social networks are dense, brokers prefer to target voters who have many ties in the network because their votes are easiest to monitor. Where networks are sparse, brokers target intrinsically reciprocal voters whose behavior they


This paper suggests that, although it is dangerous for historians to pronounce with too much confidence on so elusive a subject as the national psyche, it seems reasonable to assume that the colonial experience has been central to the formation of the contemporary Irish psyche. The attempt to create an area of psychic space free from the suffocating political and cultural embrace of a vastly more powerful England moulded the national psyche in numerous ways, positive and negative. Irish attitudes, however deviant from English "normalcy", represented a rational response to Irish circumstances. Who determines concepts of political and cultural normalcy is the central issue in the formation of contemporary Irish identity.


A channel model for routing double-layer cell arrays is presented. A switch-box is defined as an overlapping area of a horizontal channel and a vertical channel. Along the sides of switch-boxes, dynamic terminals are generated by the loose router and moved by the final router. A channel router, that is an extension of the "Dogleg Channel Router" introduced by D.N. Deutsch in 1976, is described.


This paper is an in-depth study of emergence of Corporate Social Irresponsibility (CSI) as an area that got academicians' and researchers' attention when a seminal work published in "Social Responsibility Journal" by Brian Jones et. al in the year 2009 titled "Corporate irresponsibility and corporate social responsibility: competing realities". In this paper the researcher has come out with an idea to find how the corporate social irresponsibility became prominent area of research that might bring out possible strategies the corporates may follow to enhance their corporate governance practices. This paper is an indepth study that highlights eight factors like Contractual Perspective (CP), Corporate Governance (CG), Importance of Human-Asset for Corporate Stakeholders (IHCS), Stakeholders are the Basis for Capitalism (SBC), Behavioral aspects of Economics (BAE), stakeholders' value creation (STVC), principal–agency relationship (PAR), and shareholder value creation (SHVC) are responsible thathighlights how Corporate Social Irresponsibility has grabbed the attention of many to conduct research to find plausible solution to this issue. The researcher took the response of 113 respondents and used single factor ANOVA method to test the hypothesis, "CSI factors are responsible for its emergence as a study for researchers and academicians".


Objective To observe the effect of Jiangxinxia granules on MMP-9 and TIMP-1 levels in lung of asthma rat,and explore its mechanism in airway remodeling.Methods Fifty-two male SD rats were randomly divided into nornal group,model group,dexamethasone group and Jiangxinxia granules group.The asthmatic airway remodeling model was built by subcutaneous and intraperitoneal injection of 0.2 mL antigen solution as well as repeated inhalation of ovalbumin solution.The change of MMP-9 and TIMP-1 levels in lung was examined and lung tissue with HE stain was observed after two weeks of asthma stimulation.Results The lung tissue with HE stained showed:large number of inflammatory cell infiltration,significant thickening of airway wall,infiltration of inflammatory cells around vessel wall and small blood vessels,epithelial shedding,hyperplasia of mucosal epithelial,lumen stenosis,largely thickening of basement membrane and airway smooth muscle layer,as well as thinning or rupture of part of alveolar wall to integrate into bulla were observed on the intrapulmonary bronchial submucosal of model group.The changes of dexamethasone group and Jiangxinxia granules group were similar with the control group,except for mild inflammatory reaction.The inflammatory infiltration of bronchial and alveolar was not significant compared with the model group,furthermore,integrity of mucosal structural and part fracture of the alveolar septum were found.The expression of MMP-9 and TIMP-1 levels of the model group was highly increased,great significant difference was found compared with other groups(P0.01).No significant difference was found between dexamethasone group and Jiangxinxia granules group(P0.05).Conclusions Jiangxinxia granules may exert its effects on asthma through significantly improving the general condition and pathological changes in lung tissue,regulating the expression of MMP-9 and TIMP-1,reducing the airway inflammation and slowing the occurrence and development of airway remodeling,as well as decreasing the hyper-responsiveness of airway.


Finding a solution to collect, analyze, and share, in near real-time, data acquired by heterogeneous sensors, such as traffic, air pollution, soil moisture, or weather data, represents a great challenge. This paper describes the solution developed at Eurac Research to automatically upload data, in near real-time, by adopting Open Geospatial Consortium (OGC) Sensor Web Enablement (SWE) standards to guarantee interoperability. We set up a methodology capable of ingesting heterogeneous datasets to automatize observation uploading and sensor registration, with minimum interaction required of the user. This solution has been successfully tested and applied in the Long Term (Socio-)Ecological Research (LT(S)ER) Matsch-Mazia initiative, and the code is accessible under the CC BY 4.0 license.


In bolsons in the desert regions of southern California and adjacent parts of Nevada, the area underlain by alluvial fan gravels and playa sediments is generally ˜1·2 times the area being eroded to produce those sediments. In certain larger basins in the vicinity of Death Valley, however, the depositional area is only about half the size of the erosional area. This reflects the more active tectonic environment in these bolsons.

Of the areas underlain by recent sediments in these bolsons, playas make up 2–6 per cent. Smaller playas are found in the Mojave region, and seem to be associated with sedimentary terranes. Conversely, igneous terranes support larger playas. Larger deviations of playa area from these averages are attributable to incorrect identification of bolson boundaries. Fine sediment is either able to pass through the bolson to the next down stream, or is being collected from areas upstream that were not considered to be part of the system. For example, the playa in Death Valley is unusually large. This is in part because the Death Valley playa has been deformed tectonically so parts of it are now eroding, and in part because the outlet of Lake Tecopa was downcut in the geologically recent past, so sediment once trapped there now reaches Death Valley. The size of the playa in Death Valley is still adjusting to these changes.


In theoretical physics, one often considers symmetries which change a Lagrangian by a total divergence. Such transformations preserve the equations of motion and lead to conservation laws. It is argued here, on the basis of a few examples, that the appearance of such a divergence is an indication that one is dealing with some approximation or a limiting case of a 'better' theory, in which the corresponding, possibly modified, symmetries fully preserve the action integral. These suggestions are 'metaphysical' in the sense that they cannot be tested by physical experiments.


A guide to resources on international business available through the library and beyond. How to locate journal articles on topics in international business.


The outer continental shelf (OCS), which is the undersea land beginning three miles seaward from the United States' coasts, contains one of the largest known domestic reserves of oil and gas.' The federal government, which exercises sovereign rights over the seabed and subsoil of the OCS, leases OCS lands for oil and gas development. 2 Since 1971, the federal government has sought to accelerate and expand OCS leasing in order to make the U.S. energy-independent, to alleviate balance of payments problems, and to reduce budgetary deficits. This effort has been particularly noteworthy during the Reagan administration, which has increased OCS leasing4 while seeking to eliminate the funding for vital ocean and coastal programs. 5 Coastal states have resisted the federal government's efforts to expand OCS leasing. Coastal states contend that the federal government is primarily concerned with the economic effects of OCS


The 16th century had shown that Western powers so vigorously expanded their influence in the East. Their main goal is to spread the mission of Christianization and reap wealth within the Malay world. Aceh is considered the main rival in the East because of its power as the strongest country in the Malay world and its position as a major center of trade routes. The reign of the 8th Sultan of Aceh, Sultan Alauddin Mansur Shah is regarded as a critical period for the Muslims in the East because at that time the Portuguese and the Spanish conspired to conquer the Muslim countries. The situation is causing Sultan Alauddin Mansur Shah to take steps to defend Islam and the sovereignty of the states in the Malay world. This study uses the qualitative method. The archival approach was chosen to examine the documents relevant to the scope discussed. In order for the study to be more structured, the aspect of historiography based on the sequence of events becomes a consideration. To ensure the accuracy of events within the reign of Sultan Alauddin Mansur Shah, the cross-reference technique of information is done. This technique is very important and relevant given that no thorough research has ever been conducted for the reign of Sultan Alauddin Mansur Shah with respect to the scope of the study. The result of the study indicates that Sultan Alauddin Mansur Shah emphasized the understanding of monotheism-Sufism among the community to develop the spirit of jihad against Western colonialists. Apart from that, he also implemented the constitution based on Islamic law. In order for the sovereignty of states in the Malay reserved, he has built good relations with other states of Pahang and Brunei in particular that each has a great influence within Malaya and Borneo.


In practical industrial scenarios, mechanical equipment frequently operates within dynamic working conditions. To address the challenge posed by the incongruent data distribution between source and target domains amidst varying operational contexts, particularly in the absence of labels within the target domain, this study presents a solution involving deep feature construction and an unsupervised domain adaptation strategy for rolling bearing fault diagnosis across varying working conditions. The proposed methodology commences by subjecting the original vibration signal of the bearing to a fast Fourier transform (FFT) to extract spectral information. Subsequently, an innovative amalgamation of a one-dimensional convolutional layer and an auto-encoder were introduced to construct a convolutional auto-encoder (CAE) dedicated to acquiring depth features from the spectrum. In a subsequent step, leveraging the depth features gleaned from the convolutional auto-encoder, a balanced distribution adaptation (BDA) mechanism was introduced to facilitate the domain adaptation of features from both the source and target domains. The culminating stage entails the classification of adapted features using the K-nearest neighbor (KNN) algorithm to attain cross-domain diagnosis. Empirical evaluations are conducted on two extensively used datasets. The findings substantiate that the proposed approach is capable of accomplishing the cross-domain fault diagnosis task even without labeled data within the target domain. Furthermore, the diagnostic accuracy and stability of the proposed method surpass those of various other migration and deep learning approaches.


Shanghai Oriental Hospital renovation and expansion project is very complicated due to the demand of ensuring the uninterrupted operation of the old building, the large number of mechanical and electrical systems, the difficulty of construction coordination, and the high requirements of operation and maintenance management. The paper summarizes the process and results of the comprehensive application of BIM technology. This paper focuses on three phases of application, i.e. the critical BIM application in construction period; the BIM model transformation across different stages; and the operation & maintenance phase BIM in-depth application. Through the whole process, it delivered a digital twin of the hospital′s new building, which achieves the visualization of the process of the building′s big data and the flexibilities. Finally, it has concluded the problems during the BIM implementations and has forecasted the future perspectives, which offers method to improve the qualities of model delivery, to improve the quality of information, and to expend the scope of the BIM implementations.


Diabetic nephropathy(DN) is one of diabetes-related end points,which threats the patients seriously.The glomerulus changing of podocytes plays an important role in development of DN.Podocytes lesion closely relate to tumor′s generation,development and prognosis of kidney diseases.Studying of the mechanism,drug prevention and treatment of podocytes lesion is helpful for clarifying the mechanism of kidney disorders,treatment and prognosis.


Four basins surround the Falkland Islands, but only the North Falkland Basin has been drilled; six wells were drilled there in 1998. Although all six wells encountered good quality sandstones, none of them targeted the basin margins, on what are now thought to be the optimum migration pathways associated with the basin's thick lacustrine source rocks. Subsequently, a 3D seismic survey acquired in 2004 was designed to identify potential basin‐margin ‐derived sandstones entering the basin along transfer zones. From this survey, a number of basin‐margin ‐attached fans have been identified; these prograded into lacustrine waters of varying depths. These Early Cretaceous alluvial/fan delta/deep‐lacustrine fan systems are interpreted to provide excellent potential reservoir facies as they are intimately associated with thick, mature source rocks. They will provide the focus for the next planned phase of exploration in the North Falkland Basin.


The image classification performance depends a lot on the best choice of the descriptors and the techniques used to extract them. With the exponential growth of data in the field of remote sensing, classifying these massive images still remains an open and challenging issue. The high dimensionality of the feature space, not only increases the time and space complexities, but also may reduce the image classification performance in terms of accuracy and time to build the classification model. To overcome this challenge, this paper presents a novel feature selection method based on a combinatorial optimization algorithm for training a feed-forward Artificial Neural Networks to select a small number of features while maintaining good classification rates. The performance of the proposed method is tested on real image dataset and compared with other state-of-the-art methods. The experimental results show that the proposed method has good performances.


This research aims to describe three issues that is, specific terms,
sentences, functions of the use of KUH Perdata�s language. The research is done
by using the qualitative-descriptive method which focuses on the aspecs of
language in order to identify the patterns and the arrangement of principles in
language by using qualitative model. The data are: words, clauses, and sentences
in KUH Perdata as found in Subekti and Tjirosudibyo in 2009. Then, the data is
analysed by using the language system�s analysis based on the behavior and the
characteristics distribution of particular units of language. The units of language
are observed from their relationship with another and also the contextual
relationship.
The result shows that: first, the KUH Perdata language is the translation
from Burgerlijk Wetboek (BW) that is adapted into Indonesian civil law. It is
showed from the using of Dutch, French, Latin, Portugese, England, Arabic,
Sanskrit, Java, and Minangkabau�s terms. The loan terms is used to mention the
specific law�s concept which is not included in Indonesian. Meanwhile in order to
replace the other law�s concept in BW, it is used affixation words, reduplication
words, and word combinations in Indonesian. The whole forms are used because
they are easier to be arranged, more practical, and it can represent the real concept
in Dutch.
Then, the KUH Perdata language also has the BW characteristics
especially in the arrangement of sentences that is: (a) KUH Perdata shows the
complete law�s concept that consist of the law definitions and probabilities. So
that, the complex sentence is more used than the simple sentences. (b) besides,
KUH Perdata is arranged in unseparated chapter/article so that the information can
not stand alone as the complete rule. This is showed by using of conjunction at the
beginning of the sentences which contains the old information from the previous
sentences. (c) In every civil law�s concept there must be the law information
which is more focused rather than another information. It is proved by the using of
conjunctions, prepositions, articles, adjunction words, numerical words,
questioning words, combination word at the beginning of the sentences which
functions as the particular information marker of civil law.
Next, based on the units of characteristics, it can be concluded into four
functions of the use of KUH Perdata�s language those are, the efficiency, the unity
of thought, the comprehensive and the detail of information, and also the
emphasis of law�s information.


Algorithms are commonly perceived as difficult subjects. Many applications today require complex algorithms. However, the researchers look for ways to make them as simple as possible. In high time demanding fields, the process of sorting represents one of the foremost issues in the data structure for searching and optimization algorithms. In parallel processing, we divide program instructions among multiple processors by breaking problems into modules that can be executed in parallel, to reduce the execution time. In this paper, we proposed a novel parallel, re-configurable and adaptive sorting network of the BulkSort algorithm. Our architecture is based on simple and elementary operations such as comparison and binary shifting. The main strength of the proposed solution is the ability to sort in parallel without memory usage. Experimental results show that our proposed model is promising according to the required resources and its ability to perform a high-speed sorting process. In this study, we take into account the analysis result of the Simulink design to establish the required hardware resources of the proposed system.


Abstract : The report describes a feasibility study of a chemically fueled thermionic generator and includes a study of pyrochemical fuels for this generator. The program consisted of three tasks: heat source study, materials compatibility study, and system conceptual design. System performance goals were that the generator should have a capability of from 1 to 100 kW with a minimum specific energy of 100 W-hr/lb for up to 30 minutes. Fuel preparation and processing are specified and the characteristics of three fuel combinations (Al/ KCl04, Mg/KCl04, and Mg/Teflon) were measured. A solid bed fuel or a slurry fuel system is recommended. Vapor-deposited rhenium was chosen as the combustion chamber material. (Author)


The potential contribution of community pharmacy in public health has long been recognised, and even more so with increasing attention being paid to prevention of ill-health. In the UK the 2005 community pharmacy contract for England and Wales enshrined public health for the first time as part of the everyday work of the pharmacy.1 All pharmacies are required to provide prescription-linked brief advice on issues such as smoking cessation and to participate in up to six local health campaigns each year. We have recently completed a third structured review of the international peer-reviewed literature on community pharmacy's contribution to improving the public's health. Our first two reviews covered the periods 1990–2001 and 2001–2004,2,3 and found good evidence of effectiveness of community pharmacy services relating to lipid management and smoking cessation and some evidence in other areas. However, the number of robust evaluations was small and raised issues about the strength of the evidence base for community pharmacy interventions. Here we explore these issues further by considering the evidence of effectiveness for community pharmacy-based services for weight management. The UK Department of Health has funded a trial weight-management service in the Coventry Primary Care Trust,4 and several local primary care organisations have commissioned pharmacies to provide such a service. The Pharmacy Guild of Australia recently sent Weight Loss Information Programme starter kits to pharmacies.5 The kit contains information on products, exercise, eating plans and consultations, as well as tips on promotions and staff training. Individual pharmacists will decide how they implement the programme. We selected weight management as an exemplar because it is one of increasing public health concern, and one where, in the UK, the pharmacy contract negotiators and a parliamentary group inquiry have recommended that the government should fund a national weight-management service in community pharmacies. The question is – does the evidence justify the promotion of community pharmacies as a national resource for weight management? In our first review of the literature we found one study from Denmark which reported the results of 'slimming courses' held at 19 community pharmacies for 269 obese clients.6 Average weight loss (self-reported by clients measured on scales in the pharmacy) was 5.3 kg for females and 6.2 kg for males. At one-year follow-up, 20% of clients who completed the course had maintained a weight loss of 5 kg or more. In the second review we found one US trial, in which participants were randomised to a meal replacement (MR) or reduced calorie diet (RCD) plan.7 There was follow-up for a 3-month period of active weight loss then a 10-week period of weight maintenance. The programme involved 3-weekly visits to the pharmacy (13 visits in total). Eighty-eight of 95 participants attended at least one follow-up visit and were included in the analysis. Mean weight reduction in the active weight-loss phase was 4.9 kg in the MR group and 4.3 kg in the RCD group. In the weight-management phase the mean reductions were 0.7 kg in the MR group and 0.9 kg in the RCD group. Improvements were observed in waist circumference, systolic and diastolic blood pressure, and triglyceride levels. There were no significant changes in high-density lipoprotein (HDL) or low-density lipoprotein (LDL) cholesterol. For the period 2004–2007, six studies were identified and reviewed whose focus was specifically on weight management; three involved interventions. In two of these, the service was provided for a total of 316 people and in the third, which was an extension of a national health promotion campaign, it was provided for 1370. A US weight-management pharmaceutical care service was provided in a single pharmaceutical care centre on a college campus and evaluated.8 The intervention was an initial consultation with the pharmacist scheduled for 1.5 hours, with 15-min follow-ups fortnightly until target weight was reached, then three-monthly. Data for 226 patients over the 7 years of the programme were reviewed. A further 57 people had an initial consultation and then dropped out. Mean individual weight loss was 3.6 kg, and mean duration of participation 26 weeks. One in three University of Keele, UK


A configuration is simple, stability is good, to provide an electronic expansion valve for use in high reliability refrigeration system. The present invention relates to an electronic expansion valve used in a refrigeration system, the valve body, the rotor comprises a coil and a valve needle, further positioning device comprises a lifting mechanism and limit device, the coil is provided over the valve body the rotor is attached to the valve body, in response to the coil, the positioning device is attached to the valve body, aligned with the rotor, the lifting mechanism is attached to the rotor, screwed to the rotor or the valve body, limit device provided in the valve body are used to limit the lifting range of the lifting mechanism, the upper end of the valve needle is attached to the second cavity of the lower part of the lifting mechanism. By using the positioning device, the rotor performs only rotational motion, holding the drive moment of the motor constant, it is advantageous to stabilize the operation of the valve, extending the service life of the valve. .FIELD 1


Although essential, androgens alone are not sufficient to induce normal growth and functionality of the prostate. Nonandrogenic hormones must also be involved in the proliferation of the prostate cancer cells which do not respond to antiandrogenic therapy and which thus become androgen‐independent. Prolactin, but also growth hormone and luteinizing hormone, are potentially able to act on both normal and abnormal prostatic cells.


Each person has a distinct lip printing and finger print, which are both utilized for personal identification and criminal investigations. Objective: To investigate the interaction between ABO blood group, lip prints and finger prints among both male and female participants. Methods: The study was conducted on 750 females and 550 males aged 18-50 from Lahore. Lip prints were classified using Tsuchihashi or Suzuki classification, while finger prints were classified using Kucken's or Michael's classification. Results were analyzed statistically using Microsoft Excel and SPSS version-21. Results: The pattern of loop was most common among the study group n = 1300 males (278 (50.55%), followed by Loop finger prints in 325 (43.30%) females. The most common blood type was AB+V 420(30%) among both groups. Both genders contain Type I lip pattern. The most common group of blood with fingerprint combination was AB+ve-Loop. AB+ve-Type I was the most common blood group versus lip print combination, with 104 individuals. Among the combination of lip prints or finger prints, Composite Type V had a smaller number of individuals. Both males and females scored 72. The composite type V-composite consists of A-ve, B-ve, AB-ve, or O-ve which showed the least common occurrence among the study group. Conclusions: Although blood typing, fingerprints, and lip prints each had unique characteristics. The correlation plays important role in identifying a certain person.


The authors studied catalytic effects of a Sm-(HDMS){sub 3} complex in the regioselective formation of a triple bond in prostaglandin precursors. The application of Sm(HMDS){sub 3} as a catalyst is novel. 4 tabs.