Near-infrared images of elliptical galaxies with morphological signatures of recent merger activity have been obtained. If this merger activity stimulated significant and distributed star formation within the region defined by R < 1.5Re, then JHK photometry in this region should detect the presence of an intermediate-age stellar population associated with this event. Our observations, however, show that these galaxies occupy the same locus of points in the J - H versus H - K plane as elliptical galaxies with no signs of recent merger activity. This strongly constrains the global fractional amount of intermediate-age (1–3 Gyr) stellar mass to be no more than 10%–15%, and in most cases the data are consistent with all the stellar mass being old (T > 10 Gyr) and metal-rich ([Fe/H] ≥ -0.3). We argue that any recent merger activity was, therefore, not accompanied by a significant episode of distributed star formation within the region defined by R < 1.5Re and that the bluer UBV colors often observed in this region for some of these galaxies are due to the accretion of lower mass companions or relative abundance differences. The possibility of a strongly centralized starburst resulting from the merger, instead of a more distributed star-forming episode, is fully discussed in Paper II of this series, in which similar tight constraints on this activity will be discussed.


There are two phrases: putting ice in the icehouse and offering lambs and chives as sacrifices in the last paragraph of July, one of ballads in Bin County in the Book of Songs.In current annotating versions, the purpose of putting ice in the icehouse isn't explained, or sketchy so that readers can't understand it easily. The ancients put ice in the icehouse in order to use ice after winter. Ice was applied to entertaining guests, funeral arrangements, offering sacrifices to gods and ancestors, harmonizing Yin and Yang, and regulating climate. It is a misunderstanding that the ancients offered lambs and chives as sacrifices to the ancestor of the Son of Heaven. In fact, the ancients offered lambs and chives as sacrifices to the god administering cold, which was a rite held while uncovering the ice. The rite, offering ice as a sacrifice, would be held after uncovering the ice, which had been described in detail in the ancient documents.


A novel polymer-assisted solution approach is designed for the synthesis of flexible Ag/C coaxial nanocables via one-step reduction and carbonization under hydrothermal conditions. In the process, glucose acts as reducing agent and carbon source, and CCl4 and poly(ethylene glycol) (PEG) are used in the system to control the reaction process and assist the oriented growth of the silver nanowire core.


Evidence suggests that increased glutamatergic input to the substantia nigra pars compacta as a result of hyperactivity of subthalalmic nucleus output pathways may contribute to the progressive degeneration of nigral dopaminergic neurones in Parkinson's disease (PD), a debilitating neurodegenerative disorder which affects ∼1% of people aged over 65. Substantial electrophysiological evidence suggests that the excitation of nigral dopaminergic neurones is regulated by the activation of Group I metabotropic glutamate receptors (mGluR), comprising mGluR1 and mGluR5 subtypes. As activation of these receptors by endogenous glutamate may promote multiple cascades leading to excitotoxic neuronal death, it may be hypothesised that functional antagonism of Group I mGluR should be neuroprotective and could form the basis of a novel neuroprotective treatment for PD. To investigate this hypothesis, the neuroprotective potential of the selective competitive mGlu1 antagonist (+)‐2‐methyl‐4‐carboxyphenylglycine ((S)‐(+)‐α‐amino‐4‐carboxy‐2‐methlybenzeneacetic acid; LY367385) and the selective allosteric mGlu5 antagonist 2‐methyl‐6‐(phenylethynyl)‐pyridine (MPEP) was tested in a rodent 6‐hydroxydopamine (6‐OHDA) model of PD in vivo. Both acute and subchronic intranigral administration of either LY367385 or MPEP resulted in significant neuroprotection of nigral tyrosine hydroxylase immunoreactive cell bodies, which correlated closely with prevention of striatal monoamine depletion following 6‐OHDA lesioning. This neuroprotective action of LY367385 and MPEP displayed a clear concentration‐dependent effect, suggesting a receptor‐mediated mechanism of action. LY367385 produced robust neuroprotection at all concentrations tested (40, 200 and 1000 nmol in 4 μL), whilst MPEP displayed a bell‐shaped neuroprotective profile with significant neuroprotection at low concentrations (2 and 10 nmol in 4 μL) but not at higher concentrations (50 nmol). Importantly, subchronic intranigral administration of MPEP and LY367385 appeared to slow the degeneration of remaining nigral dopaminergic neurones and prevented further striatal dopamine depletion in animals with established 6‐OHDA induced nigrostriatal lesions, suggesting that these compounds may significantly influence disease progression in this model.


Objective:To study effects of rehabilitation exercise in patients with arrhythmia.Methods: 55patients were randomly divided into light and moderate exercise intensity group.The duration of ex- ercise session was0 .5- 1h,1- 2 session/ d.Results:81.9% of the patients with arrhythmia have signifi- cance effects,and85.5% have effects for all patients with arrhythmia.Conclusion:The results suggest rehabilitation exercise may ameliorate myocardial ischemia and have significant effects on patients with arrhythmia. Author′s address Dep.of cardiology,First Affiliated Hospital of Jiamusi Medical College,Jianmusi, 1540 0 2


Abstract The study was conducted with 49 coronary artery disease confirmed inpatients admitted in Nizam's Institute of Medical Sciences, Hyderabad and 24 matching controls to correlate the dietary patterns with lipid profiles. Detailed information on their dietary habits and behavioral parameters were collected through a structured questionnaire. Food intake was assessed by the 24 hour recall method and blood samples were drawn after 12 hours of fasting and analysed for lipid profile by enzymatic colorimetric method. Results of the study have indicated that coronary artery disease patients were obese and risk factors such as smoking (24 percent), alcohol consumption (8 percent), pan chewing (4 percent) were observed among the patients. Lipid profile of the control and coronary heart disease patients indicated significantly higher levels of total cholesterol, triglycerides and LDL levels when compared to control. The mean triglycerides (228 mg/dl and 143.66mg/dl) and LDL (137 mg/dl and 119.74 mg/dl) and HDL (34 mg/dl and 38 mg/dl) were seen in patient and control population respectively.


Let an n x m matrix of observations, Y, have distribution N(XB, G V),where X, G 0 and V 0 are known n x p) n x n and m x m matrices respectively,B is an unknown P x m matrix of parameters. We consider the problem of estimatingthe loss L = (SXB - SXB)C(SXB - SXB)', where S and C 0 are known t x n andm x m matrices respectively B = (X'G-'X)-X'G-'y It is pr0ved that the uniformlyminimum risk unbiased estimator of L, L. = (trCV)SX(X'G-'X)-X'S', is admissiblefor q = rankSX = 1 and m 4, or for q 2 and m 2 and inadmissible for m 5 witha matrix loss function. It is also shown that the above Lo is a r-minimax estimator 0f Lagainst a class of priors.


P. brasiliensis conidia were studied for their ability to grow as yeasts or as molds according to temperature. Using a microculture system we found that such conidia shared the ability of the parent mycelium to transform directly into multiple-budding yeast cells at 36 degrees C or to produce germ tubes and branching mycelia if kept at 22 degrees C.


In two separate experiments, steers that had been fed hay in a feedlot lost weight during their first week at pasture whereas similar animals that grazed pasture throughout at least maintained liveweight. There was no difference in the grazing time per head of animals previously lot fed and those accustomed to grazing but steers previously from feedlots grazed longer per unit of metabolic liveweight. Length of pasture available for grazing following the feedlot phase was important. Differences in liveweight change between steers previously from a feedlot and those from pasture were less when animals grazed a tall rather than a short pasture. The reduction in loss was not significant.


This is the first reported case of a 54 years old woman who under went extracapsular cataract extractions with posterior capsular lens inplantations.After 2 1/2 years and 6 months follow up period both eyes were quiet,the corneas were clear.The retina were normal.The visions of both eyes were lower that normal because of the deposition of brownish glistening pigments to the anterior and posterior surfaces of both implants and also from organized fibrin to the front surfacr of the left implant.However she could read 6/9-2 after correction with Plano = -0.25D.,-0.50D.g;asses.On reading she could read 20/30 with +3.00 glasses.The visual fields were 30 degrees less than normal.


in the second century. Instead of looking for every bit of gnostic dualism, Valentinian mythology, and deterministic anthropology, W. looks for examples of correcting the text, glossing words or phrases, clarifying genealogy, topography, chronological order, or other facts in a narrative. Not only do Heracleon's comments show a concern for such details, they also address differences between the Fourth Gospel and Synoptic versions of the same material. In part, Heracleon demonstrates the same concern for a single account of the Savior's mission that led Tatian to produce the Diatesseron. However, Heracleon does not seek to produce a narrative "life of Jesus." His reading of the Johannine Prologue shows a familiarity with Middle Platonic categories and interest in the vertical relationship between the divine and material realm already evident in Philo's exegesis of Genesis. W. makes a compelling case against the view that Heracleon is a radical dualist. Unlike his contemporary, Marcion, Heracleon does not posit a complete break between the God whose salvation became present in Jesus and the demiurgic creator of the material world, who is also "god of the Jews." Like the demiurge of Plato's Timaeus, Heracleon's Demiurge reflects the necessary weakness and ignorance that goes with the material world. However, the Word is able to descend into that world to illuminate, save, and rectify those elements of the divine that have become lost there. Is this depiction of salvation gnostic? W. would agree that it stands at the beginning of the more elaborate speculative systems found in Valentinian schools of the late second and third centuries. But within the context of mid-second-century Rome, distinctions between Christian sects are less easily drawn. He prefers to read Heracleon as evidence for a dynamic period in which Christians are just beginning to seek out intellectual categories for understanding their faith. He points out that Heracleon already has a sense of the New Testament canon of four Gospels and Pauline letters. He is not using such apocryphal "gnostic Gospels" so much in fashion on the scholarly left today. Though one might quibble over detailed points, W. provides a welcome new perspective on this facet of early Christian exegesis.


Thornwaldt's cyst occurs in the midline of the nasopharynx (space behind nasal cavity).Although it is relatively uncommon and majority are asymptomatic, it may cause significant symptoms. We present a case of young male who presented with history of snoring, stuffy nose and unusual heaviness in head. He had a history of irregular clinician consultation due to transferable nature of his job. On detailed history and work-up, he was found to have symptomatic Thornwaldt's cyst with chronic pansinusitis. This case report highlights the importance of endoscope-assisted powered instrumentation; ie. microdebrider assisted surgery (MAS) under endoscopic guidance in management of the case. Author Affiliations: Roohie Singh, Military Hospital, Jodhpur (India), Jeevan R Galagali, Command Hospital ,Pune (India), 3 N Ramakrishnan, Armed Forces Medical College, Pune (India), 4 Santosh Kumar, Military Hospital, Jodhpur (India).


In this paper, the function of auxiliary safety management subsystem of railway permanent way which used in the state analysis of the track is introduced. The content and process of the auxiliary management subsystem used in the state analysis of the track; the relationship between all components of the system is also shown clearly by the function relationship diagram.


The concept that the B-cell Receptor Complex (BCRC) initiates the dominant driver pathway in leukemia-lymphoma is clinically validated. However, the BCRC has been overlooked as a therapeutic target due to homology between the BCRC's membrane Ig (mIg) subunit and circulating serum Ig. Previously, we reported the generation of a first-in-class antibody, WBMP-4, to a neo-epitope specific to the mIgM-BCRC, which inhibits cell growth and induces apoptosis (Welt et al. 2016).
 Here we evaluate kinase activity in Burkitt lymphoma (CA46) cells treated with WBMP-4 (at 5 and 20 ug/mL, and at 6 and 24 hours) via the Pamgene phosphotyrosine kinase assay. This assay measures kinase activity in cell lysates using a microarray chip containing peptide sequences that serve as substrate for phophsotyrosine sites on well-characterized signaling proteins. We measure kinase activity at 189 phosphosites using this array, as well as protein expression and phosphorylation of key targets downstream of the BCRC using ELISA, flow cytometry, western blot, and immunohistochemistry, in WBMP-4-treated and untreated IgM-expressing B-cells.
 Our Pamgene analysis reveals widespread kinase modulation following WBMP-4 treatment, with >180 of 189 phosphosites showing a significant change in phosphorylation signal intensity (with >153 showing a significant decrease) upon treatment. Western blot analyses of downstream BCRC kinases similarly show changes in phosphorylation at analyzed phosphosites (ZAP70, mTOR, AKT, and MEK) with WBMP-4 treatment. However, we also find changes in protein expression levels of CD79b, ZAP70, BTK, MEK, Myc (all decreased), and LCK (increased) following WBMP-4 treatment.
 We show that the kinase activity of proteins in multiple signaling pathways is altered upon WBMP-4 binding to the BCRC's mIgM, with the vast majority exhibiting a downregulation of phosphorylation. We also find that protein expression is impacted in several kinases directly under the control of the BCRC. We hypothesize that WBMP-4's impact on protein expression contributes to BCRC signal disruption and the cytotoxic effect achieved by WBMP-4. For example, WBMP-4 induces a profound reduction in CD79b expression (undetectable by western blot following WBMP-4 treatment), which is consistent with the reduction in CD79a kinase activity found via Pamgene assay. These data support the concept that WBMP-4 binds an epitope on mIgM that is critical to its signal transduction to CD79a/b.Due to WBMP-4's specific targeting of IgM-expressing B-cells, we expect that the toxicities associated with approved therapies upon their interaction with non-lymphatic tissue (e.g. bleeding, infection, cytopenia, arrhythmia, secondary malignancies) will be avoided. With potent anti-tumor activity and expected reduced toxicities, WBMP-4 is a compelling candidate for clinical development.
 Citation Format: Rachel S. Welt, Jonathan A. Welt, Virginia Raymond, David Kostyal, Sydney Welt. Anti-membrane IgM monoclonal antibody, WBMP-4, induces apoptosis in B-cell malignancies by modulation of kinase expression and phosphorylation. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4880.


Coastal wetlands include littoral zones, brackish water and estuarine regions, lagoons and coral reefs. These wetlands in the world being great ecological and economic significance, global efforts are being made to manage these resources on a sustainable basis. In addition, wetlands also play a major role in feeding and breeding areas for marine habitat and provide a stopping place for marine turtles. An attempt has been made here to map a reliable and precession thematic database for coastal geomorphology, land use and wetlands of Krishna district. For attain this, IRS LISS IV satellite data and SOI topgraphical maps on 1:25,000 scale are used. Geoinformatics tools like Remote Sensing (RS), Geographic Information System (GIS) and Global Positioning System (GPS) have been used for mapping. In recent years, RS & GIS have been proved for effective resources management and coastal environmental monitoring. Eighteen types of coastal wetlands are identified in the study area covering a total area of 1042 km 2 . The generated spatial information on coastal geomorphology, land use and wetlands will aid in understanding the spatial distribution and extent which will ultimately help in further planning and taking in time appropriate decisions for sustainable development.


The state-of-the-art training of deep neural networks requires to normalize the activities of the neurons for accelerating the training process. A standard approach is to employ batch normalization (BN), in which the activations are normalized by the mean and standard deviation of the training mini-batch. To be invertible, BN also introduces an adaptive gain and bias which are applied after the normalization but often before the non-linearity. In this paper, we investigate the effects of learnable parameters, gain and bias, on the training of various typical deep neural nets, including ALL-CNNs, Network In Network (NIN), ResNets. Through extensive experiments, we show that there is no big difference in both training convergence and final test accuracy if we remove the BN layer following the final convolutional layer from a convolutional neural network (CNN) for standard classification tasks. We also observed that without adaptively updating learnable parameters for BN layers, it often requires less time for training of very deep neural nets such as ResNet-101.


3D-ordered closed macroporous Al2O3 was prepared by the codeposition method using PMMA as the template and Al2O3 colloidal particles as the building block. The ordered closed structure of the macro...


The prediction accuracy rate of the types of multi-factor associated injuries in the risk assessment model has been tested with 122 test data, resulting in that the correct recognition rate of the injury consequences of the adjusted model was about 75%, the identification accuracy rate of two kinds of risk factor-related events in the categories of the mechanical injuries and inorganic poison hazards reached 78%, and that of the other eight categories of risk factor-related hazard events was higher than 75%, which confirms that the test results of the risk assessment model are satisfying. After reinforcement learning, the test accuracy of the strong classifier has been improved to 81%, indicating that the reinforcement learning module has increased the generalization ability of the model at a certain extent, and the Bayesian network method combined with reinforcement learning may have stronger applicability. In the structure learning, the conditional probabilities as shown in Table 5, Table 6, and Table 7 are obtained, and the relationship that different factors cause a certain hazard is revealed, consequently to confirm how the key factors of a certain injury that is occurred.


[...]workplace concerns, such as low staffing levels, low morale, and subsequent burnout, are pushing nurses out of health care entirely. In those settings, resources are limited and have been for decades. [...]complexity characterizes the needs of all residents under these nurses' care. [...]nursing homes specifically need policy and practice changes to optimize scope of practice and provide around-the-clock professional nurse leadership. Other local efforts include nursing schools offering robust clinical rotations in nursing homes and programs providing opportunities to students to work in long-term care facilities.


The author center around the development of glossary as well as it clings to period for its own sake.And it tells us how to interpret column in English——Chinese.


This paper proposes a new hybrid temperature compensation system for doped silicon-based piezoresistive 3D stress sensors. The developed compensation system integrates a temperature sensor, placed in close proximity to the stress sensing rosettes, with the artificial neural networks (ANNs). In this work, the n-type circular piezoresistor featured over (111) silicon plane was employed to capture the local temperature variations, within the sensing chip. The extracted temperature changes, along with the resistance changes, are fed, as inputs, to the ANNs to compensate the temperature effect on the acquired signals for more accurate stress measurement. The proposed compensation system was experimentally evaluated while extracting stress applied up to 60 MPa at different temperatures within a range from 0 °C to 50 °C. The developed system was successfully able reduce the maximum full scale error, obtained from using only a temperature sensor for compensation, by ~55%. The new system has merit since it has the capability to compensate for both resistance and sensitivity, for 3D stress sensor, with no need for additional circuitry. Moreover the employed temperature sensor shares the same thermal environment with the stress sensing rosette.


The need for objective methods of assessment of the patient with rheumatoid arthritis who is being treated with anti-inflammatory agents has been accentuated by the development of numerous new drugs. O'Brien (1968) summarized antecedent drug evaluations and showed a correlation of improved joint function in 56 per cent. of studies without objective assessment versus only 34 per cent. improved status when objective measurements were included. While no single parameter or summation index adequately measures disease activity of rheumatoid arthritis in all patients, proximal interphalangeal joint size is easily assessed, and changes here often reflect changes in overall disease activity. Herein described is a simple device which accurately, rapidly and easily measures proximal interphalangeal joint size.


Looking at the surrounding roads we live, we are quite at a loss because we cannot lay our eyes in such a flood of sign information. In particular, it is natural if we visit there for the first time. It is dizzy to see various signboards, street trees, installations, telegraph poles, signal lights, standing signboards, and projecting signboards in varied letter size and colors. For foreigners visiting Korea for the first time, complex signboards and signs are their first impression on Korea and greatly contribute to decide a city image. Private signboards refer to a kind of guide sign to guide major public facilities or tourist and leisure facilities built by the competent authorities. Although there are regulations on the criteria and methods to build them, their specified scopes and methods are not sufficient, resulting in crowded signboards. It brings about drivers" obstacle to sight distance, spoiling the beauty of the town, and confused information. For this reason, this study was purposed to examine the situation of private signboards in a section between Buk-gu Office and Malbau Market and promote the integration of visual information of private signboards by making improvement and presentation. Finally, this study focused on the suggestion of private signboards information in advanced cities by grasping the situation and problems of guideline manuals for private signboards in Gwangju Metropolitan City.


Intoxication with the carbon monoxide leads to the development the early and delayed neuropsychological impairments. Oxygen therapy is used usually as an antidote for the treatment of acute carbon monoxide poisoning. The synthetic analogues of endogenous peptides were shown to prevent the neuropsychological impairments. One of them is KK1, a tetrapeptide acetyl-(D-Lys)-Lys-Arg-Arg-amide, assessed as a structural analogue of corticotropine. The efficiency of the synthetic tetrapeptide KK1 for the prevention of the CNS delayed impairments after acute carbon monoxide poisoning has been evaluated in this study.


Since its beginning in 2008, the Smithsonian-Mason School of Conservation has offered semester-away programs for undergraduates by integrating hands-on, multidisciplinary study with topic-focused case studies.A'  Our courses emphasize experiential, solution-oriented learning and integrate Mason and Smithsonian researchers and experts into our teaching.A' Our first objective was to evaluate the studentsA¢â'¬â"¢ learning gains in the semester program, using data generated from student learning evaluations from 2008 to the present.A'  Next, we investigated long-term career development outcomes in our alumni, specifically focusing on how well our programs prepare them to find employment in the field of conservation and/or engage with current problems in conservation.A'  We contacted 50 Semester alumni to follow up on their progress and professional growth since matriculation from our program. A' A' The initial findings demonstrate significant growth in learning between pre- and post-tests.A'  The follow-up interviews indicate that most alumni are using the skills they developed in the semester in their professional careers and have incorporated conservation principles into their daily lives.A'  Next steps include a formal analysis of the interviews, with a focus on understanding the role of research experiences in studentsA¢â'¬â"¢ professional development and an eye towards developing new programs that best serve our studentsA¢â'¬â"¢ needs.


An open, multicenter study investigated the long‐term efficacy, tolerability, and acceptability to patients of subcutaneous sumatriptan 6 mg, administered using a novel cartridge system self‐injector, for the acute treatment of migraine. Eighty patients treated all migraine attacks for 6 months at home with a subcutaneous injection of sumatriptan 6 mg. A second injection could be taken after 1 to 24 hours if relief was inadequate, or if the headache recurred, and rescue medication could be taken 1 hour after the second injection. The primary end point was the percentage of attacks in which headache improved from severe or moderate before treatment to mild or absent at 1 hour after the first injection. A total of 1566 attacks were treated by the 80 patients and 69 patients completed 6 months of treatment. Headache relief was reported 1 hour after the first injection in a mean of 78% of attacks (83% in the first 3 months and 76% in the second 3 months). A second injection was required in a mean of 40% of attacks, and headache was mild or absent 1 hour after the second injection in a mean of 77% of attacks. Rescue medication was required after the second injection in a mean of 14% of attacks. At the end of the study, 87% of patients said that they would take the medication again, and at each clinic visit over 80% said that they found the injector easy to use. Adverse events were similar to those reported previously with sumatriptan and were mostly mild to moderate in intensity, short‐lived, and resolved spontaneously.


Phosphorescent OLEDs are under intense investigation because of their potential in greatly improving device performances. Electrophosphorescence is easily generated from both singlet and triplet excited states so the internal quantum efficiency of phosphorescent organic light-emitting diodes (OLEDs) can reach a theoretical level of unity, rather than the inherent 25% upper limit imposed by the formation of singlet excitons for their fluorescent counterparts. Thus, a great deal of effort has been spent investigating the third-row transition-metal complexes to develop highly efficient phosphors that can emit all three primary colors. Despite elegant research on both red and green phosphors, there are only a few reports on room-temperature blue phosphors. Two wellunderstood examples, bis(4',6'-difluorophenylpyridinato)iridium(III) picolinate (FIrpic) and bis(4',6'-difluorophenylpyridinato)iridium(III) tetra(1-pyrazolyl)borate (FIr6), have proven to be excellent dopants for greenishblue and sky-blue phosphorescent OLEDs. Further improvements were made by substituting the picolinate ions with other ancillary ligands, such as triazolate or tetrazolate ions to give FIrtaz or FIrN4, respectively, and even by employing a combination of cyanide and phosphine ligands. These modifications have produced a hypsochromic shift of around 10 nm compared to the emission of FIrpic. However, significant lowering of emission quantum yield was noted in some cases, which has hampered the fabrication of true-blue phosphorescent OLEDs. In theory, some critical criteria have to be considered in obtaining highly efficient blue phosphorescence. Of primary importance is to increase the contribution of the metal-toligand charge transfer (MLCT) in the lowest-lying triplet manifold. The direct involvement of the metal dp orbital enhances the coupling of the orbital angular momenta to the electron spin, such that the T1!S0 transition would have a large first-order spin–orbit coupling term, which would result in a drastic decrease in the radiative lifetime and hence the possibility of increasing the quantum yield. Conversely, care has to be taken to avoid enhanced radiationless pathways arising from enlargement of the band gap. One familiar deactivation pathway lies in the d–d transition, which may weaken the metal–ligand bond, thus resulting in a shallow potential-energy surface. In an extreme case, the shallow d–d potential-energy surface may intercept surfaces of other states, which may result in radiationless deactivation. This process, however, should be minor for third-row transition metals owing to their high coordination strength that increases the energy of the ds* orbitals. Furthermore, upon increasing the energy gap towards blue, it becomes facile for the lowest-lying excited state—a state perhaps comprising both p–p* (or intraligand charge transfer, ILCT) and MLCT in character—to mix with a thermally accessible ligand-to-ligand charge-transfer (LLCT) state. Mixing with the LLCT state may increase the radiative lifetime owing to the largely charge-separated character of this state and hence the probability of a partially forbidden transition (versus the ground state). The net result is a reduction in the corresponding emission quantum yield if similar deactivation mechanisms operate. In our view, the above scenario may be avoided by selecting facially arranged homoleptic complexes or by using [*] C.-H. Yang, Dr. Y.-M. Cheng, Prof. Y. Chi Department of Chemistry National Tsing Hua University Hsinchu 300 (Taiwan) Fax: (+886)3-572-0864 E-mail: firstname.lastname@example.com


This technical report summarizes the data in the Renewable Electric Plant Information System (REPiS), a database of all known grid-connected renewable electric facilities in the US. It was originally designed in 1985 and updated in 1990 and 1994. The design of the database is discussed; some of the results of common search queries of the database are summarized. Data is presented on the amount of renewable electric capacity nationally that is operated, retired, planned, or of unknown status, as well as operating and planned renewable electric capacity state by state.


In this paper,we mainly study some properties of WGP-injective modules,and discuss the divisibility of WGP-injective modules on no-zero-divisor rings.We also prove that if R is a no-zero-divisor right duo ring,then left R-module M is a WGP-injective module if and only if M is divisible.


In the UK there are approximately 100 000 people with a permanent stoma and around 21 000 new stomas are formed each year. In this article, Joy Notter and Frances Chalmers describe the results of a postal survey, designed as a pilot for a bigger national study. This survey explored issues impacting on quality of life for those living lifelong with a colostomy. Over 97% of respondents were over 50 years of age, and almost 30% reported complications necessitating further admissions and/or more surgery. Restrictions on activities of daily living (including social activities with family and friends) were present for 40% of the sample; 50% reported leakage and 33% found disposal problematic. Overall, the survey yielded a wealth of information and identifed areas where specialist help and advice are important.


A new hypothesis concerning ozonation of humics has been recently published by Jansen et al. (1). According to the authors ozonation causes outside-in trimming of humic molecules producing small molecules as ozonation byproducts. This leads to a gradual decrease of large initial molecules to smaller remainings. The research suggests that HS molecules consist of "a relatively stable backbone network structure" and the HS molecules degrade by trimming out small, "external" parts of the molecules. I do not think it is really true. The hypothesis is based on a few experiments done on one kind of humics only with a relatively low polydispersity. The experiments were carried out with relatively high ozone dosages; the lowest ozone dose was equal to 1.3 mg O3/mg Corg. The authors seem to leave out a substantial part of past research done on humics. Comparison of their results with the results obtained with more dispersed samples of humics would force the authors to revise their hypothesis. For example, according to Nissinen et al. (2) ozonation leads to almost complete disappearance of the humic fractions with the highest molecular weight. The same has been clearly shown by Vuorio et al. (3) and Kainulainen et al. (4). This would rather support the hypothesis of "cutting" of HS into pieces. The first effect observed upon an ozonation of humic substances is a dramatic decrease of color. This is shown by the authors in their Figure 2b, however they completely ignore chemical phenomena responsible for the effect. The rapid decrease of color is mainly caused by the cleavage of the aromatic rings (5, 6). The extent of the observed decrease is an evidence that the destruction of aromacity proceeds on virtually all available rings and not only those located at external boundaries of the HS molecules. The destruction of aromatic rings leads to the formation of unsaturated carboxylic acids that are further easily destroyed by ozone molecules (e.g., 7). This, in general, falsifies the hypothesis of the authors concerning "the relative stability of backbone network structure of HS". Also some experimental details need to be clarified since they may lead to the misinformation of the ES&T readers: Determination of humic acids molecular weights was based on the calibration graph obtained for pollulans (polysaccharides). It is not necessarily the best way of calibration since the polysaccharides are neutral compounds in contrast to the HS molecules that are ionized at neutral pH. This simply leads to overestimation of the measured apparent molecular weight due to the ion-exclusion effect. Thus ionized standards (such as polysulfonated polystyrenes) are probably better than neutral compounds. This has been proved by Perminowa et al. (8) (see also comments in ref 12 of the Jansen et al. paper). Ozonated humic acids perhaps are even more ionized due to many more carboxylic groups (9) in the molecules and thus again their molecular weights might be overestimated to a greater extent. Close observation of carboxylic acids' elution times in Figure S2 (of the Jansen et al. Supporting Information) confirms the overestimation of the acids molecular weights by the calibration graph. The second problem which can lead to some misinformation of the readers lies in the procedure of determination of ozonation byproducts. The authors have used ion-exclusion chromatography (and not ion chromatography nor HPLC) to determine the byproducts. The method has one, but a serious, disadvantage when used for such a purpose: due to a very low pKa value, the oxalic acid cannot be determined at pH of 0.0005 M H2SO4 (mobile phase). The mobile phase pH is too high to keep the acid in un-ionized form and thus it elutes together with all the excluded anions of other strong acids at the beginning of the chromatogram. That is why the authors did not see and could not quantify oxalic acid. According to earlier research (e.g., 10-13) oxalic acid is one of the main carboxylic ozonation byproducts. It is formed mainly by the destruction of aromatic rings (see for example refs 5 and 6). The amounts of the acids generated upon ozonation are usually much higher (approximately 1 order of magnitude) than those of aldehydes (10, 11). The chromatogram presented in Figure 7 gives an impression to the readers that aldehydes and carboxylic acids are generated at approximately the same level while this is not certainly true. Also the identification of peaks in Figure 7 (or the information provided in the Materials and Methods section) seems to be doubtful: how could authors detect glyoxal, methylglyoxal, and acetaldehyde with a conductometric detector? Literature Cited (1) Jansen, R. H. S.; Zwijnenburg, A.; van der Meer, W. G. J.; Wessling, M. Outside-In Trimming of Humic Substances During Ozonation in a Membrane Contractor. Environ. Sci. Technol. 2006, 40, 6460-6465. (2) Nissinen, T. K.; Miettinen, I. T.; Martikainen, P. J.; Vartiainen, T. Molecular Size Distribution of Natural Organic Matter in Raw and Drinking Water. Chemosphere 2001, 45, 865-873. (3) Vuorio, E.; Vahala, R.; Rintala, J.; Laukkanen, R. The Evaluation of Drinking Water Treatment Performed with HPSEC. Environ. Int. 1998, 24 (5/6), 617-623. (4) Kainulainen, T.; Tuhkanen, T.; Vartiainen, T.; HeinonenTanski, H.; Kalliokoski, P. The Effect of Different Oxidation and Filtration Processes on the Molecular Size Distribution of Humic Material. Water Sci. Technol. 1994, 30 (9), 169-174. (5) Helleur, R.; Malaiyandi, M.; Benoit, F. M.; Benedek, A. Ozonation Of Fluorene and 9-Fluorenone. Ozone Sci. Eng. 1979, 1 (3), 249-261. (6) Kusakabe, K.; Aso, S.; Hayashi, J.-I.; Isomura, K.; Morooka, S. Decomposition of Humic Acid and Reduction of Trihalomethane Formation Potential in Water by Ozone with UV Irradiation. Water Res. 1990, 24 (6), 781-785. (7) Poznyak, T.; Vivero, J. Degradation of Aqueous Phenol and Chlorinated Phenols by Ozone. Ozone Sci. Eng. 2005, 27, 447-458. (8) Perminova, I. V.; Frimmel, F. H.; Kovalevski, D. V.; AptBraun, G.; Kudryavtsev, A. V.; Hesse, S. Development of a Predictive Model for a Calculation of Molecular Weight of Humic Substances. Water Res. 1998, 32, 872-881. (9) These, A.; Reemtsma, T. Structure-Dependent Reactivity of Low Molecular Weight Fulvic Acid Molecules during Ozonation. Environ. Sci. Technol. 2005, 39, 8382-8387. (10) Nawrocki, J.; SÄ wietlik, J.; Raczyk-Stanisławiak, U.; Da̧browska, A.; Biłozor, S.; Ilecki, W. Influence of Ozonation Conditions on Aldehyde and Carboxylic Acid Formation. Ozone Sci. Eng. 2003, 25, 53-62. (11) Xie, Y. F. Disinfection By-products in Drinking Water; Lewis: Boca Raton, FL, 2004. (12) Weinberg, H. S.; Glaze, W. H. An Overview of Ozonation Disinfection By-products. In Disinfection By-products in Water Treatment; Minear, R. A, Amy, G. L., Eds.; Lewis: Boca Raton, FL, 1996. (13) Myllykangas, T.; Nissinen, T. K.; Rantakokko, P.; Martikainen, P. J.; Vartiainen, T. Molecular Size Fractions of Treated Aquatic Humus. Water Res. 2002, 36, 3045-3053.


Summary We report whether the different modes of cooling with ice the epidermis influence the number of sessions required to treat hemangiomas in children with Nd:YAG laser and ameliorates the cosmetic end result. Between 1993 and 2002 235 children with cutaneous haemangiomas were treated with an Nd:YAG laser. The patients were divided into 2 groups according the mode of cooling the epidermis with ice. The first group contained 115 patients where the epidermis was cooled with ice only during the irradiation. In the second group, contained 120 patients, the epidermis was cooled with ice, prior to, during and after irradiation. The protection of epidermis with ice prior to, during and after irradiation with Nd:YAG laser had better cosmetic results and decreased the number of sessions for treatment, than the epidermis protection only during irradiation.


State Key Laboratory of Continental Dynamics, Department of Geology, Northwest University, Northern Taibai Str. 229, Xi'an 710069, China. Corresponding author: email@example.com ___________________________________________________________________________ The East Kunlun Orogen, located at the northern Tibet Plateau, represents the western segment of the Central China Orogenic Belt which was formed by amalgamation of the North China blocks and South China blocks. It is a key to understanding the formation of Eastern Asian continent as well as the evolution of the Pangea supercontinent. Based on detailed geological mapping, geochemical and geochronological investigations, the orogen is divided into three main tectonic belts, from north to south, including the Northern Qimantagh, Central Kunlun and Southern Kunlun Belts by the Qimantagh suture, Central Kunlun suture and South Kunlun fault.


The nitrogen source of fermentation medium of agri-antibiotic 2507 was soybean mill.When animal protein beef extract was used,the potency unit was increased.The medium composition for fermentation has been selected by means of orthogonal analysis method and obtained the optimal medium.The production of potency was 696.9% higher than original fermentation medium in shaker of fermentation.


The separation of cholesterol from butteroil was achieved by various processes based on contacting it with aqueous solutions of Quillaja saponaria saponins followed by separation of the cholesterol-saponin complex. Alternative processes and controls studied were (1) Water Control (W): butteroil was contacted with pure water; (2) Reaction (R): butteroil was contacted with aqueous solution of saponins; (3) Adsorption Control (A): butteroil was contacted with water, diatomaceous earth was then added; (4) Reaction + Adsorption (R+A): diatomaceous earth was added to the Reaction medium (from 2); (5) Reaction + Washing (R+W): the aqueous phase resulting from Reaction (2) was discarded and pure water contacted with the fat. the last step in all the above processes and controls was the separation of the fat phase, after which analyses were made. ANOVA indicated that the Adsorption Control process did not yield any significant cholesterol reduction over the Water Control; all other processes resulted in significant cholesterol separation in the order R+A > R+W > R. the levels of cholesterol reduction achieved by the R, R+W, and R+A processes were significantly affected by the concentration of quillaja solution and temperature; the level of agitation had no significant effect over the range investigated. Quillaja powder residue was present in the fat phase after Reaction (2) but both adsorption and washing procedures significantly reduced it.


Purpose: The purposes of this study were to develop a community-based Mind Subtraction meditation program for cancer survivors and examine the effectiveness of the developed program on quality of life, life satisfaction, and expectancy of satisfactory life in cancer survivors. Methods: This study used a one group, pretest-posttest design. A 5-week community-based meditation program for cancer survivors was offered twice a week with each session up to 2 hours. 10 cancer survivors who had completed cancer treatments participated in this study. Data were collected using self-reported questionnaires and personal journals about the meditation experience from September 10 to December 11, 2015 at a health center branch in Seoul, South Korea. Results: There were statistically significant differences in physical domain of quality of life (QOL) expectancy of satisfactory life. Conclusion: This study shows that the community-based Mind Subtraction meditation program for cancer survivors can be considered as an effective nursing intervention to improve quality of life and expectancy of satisfactory life among cancer survivors in a community setting.


Implementing morphological competence of derivational affixation has been reported to improve students" vocabulary acquisition (Sudana, 2006). Attempts need to be done to construct learning materials that can help learners develop such competence. Using concordance software, this study has analysed various texts of about five hundred thousand words: texts of TESOL, literature, linguistics, and education to look for frequency distribution of affixes. The result of the analysis has provided data based information on the behaviour of ten most frequently used English derivational affixes in the corpus (5 prefixes and 5 suffixes). This information has been consulted to construct language teaching materials to help learners develop their morphological competence of derivational affixation to improve their vocabulary acquisition.


Abstract River water pollution has been reported globally. In suggestion to adapt sustainability approach, this study carry out to tests the structural equation model between sustainable development and water resources management in the Malacca River basin (Malaysia). The model consists of six latent constructs (anthropogenic activities; law, regulation and policy; land and water ecosystem; Malacca River; river water pollution; sustainability) and twenty four items based on 400 questionnaires which were completed and returned by the local residents of Malacca state. Selected study area is within Malacca River basin. The result show the Malacca River is influenced by water law-regulation-policy (β = 0.546, p < 0.001), anthropogenic activities (β = 0.145, p < 0.001), river water pollution (β = 0.142, p < 0.001), land and water ecosystem (β = 0.105, p < 0.01), as well as sustainable approach (β = 0.127, p < 0.5). It was found that a sustainable approach and water law-regulation-policy have a direct influence on anthropogenic activities, river water pollution, as well as the land and water ecosystem. In conclusion, this study suggests developing an earlier approach of the model involved with water resources management and sustainable development.


Major themes and guidelines for the development of content in international nursing for graduate programs are proposed and discussed. The major themes identified are frameworks for delivery of services in health care, education and/or research, strategies to enhance understanding of international roles, issues in international health care, culture and health, and intercultural communication. These themes were operationalized into more specific guidelines for content in graduate programs. The proposed guidelines complement others that are discussed in the literature that focus on graduate education in nursing in general.


"The law should take its course". With this pronouncement, Lieutenant-General Sir William Jervois, Governor of New Zealand, sealed the fate of Rowland Herbert Edwards. The Governor's words conveyed his confirmation of the death sentence that had been imposed upon Edwards for the murder of his wife, Mary, following his trial in the Supreme Court at Napier.  This article explores the trial of Rowland Edwards and the questions that persist about the quality of the trial that resulted in Edwards' execution in circumstances where a verdict of not guilty by reason of insanity was reasonably available.


【Objective】 The study was conducted to promote the development of agricultural mechanization coordinately and rapidly by making appropriate guidance according to local conditions on the basis of evaluation and regional division.【Method】 In this paper,an evaluation index system of agricultural mechanization development was built,and the national agricultural mechanization development was divided into five regions with a comprehensive evaluation index.【Result】 Considering both benefits and costs of the development of agricultural mechanization,an evaluation index system of agricultural mechanization development was reconstructed with three basic indexes and one reference index.The evaluation result of three basic indexes and the comprehensive evaluation reflected the characteristics and keys of the country and the provinces(cities,districts).Comprehensively considering the distribution and the results of comprehensive evaluation,the development of agricultural mechanization in the country was divided into 5 regions.Through comparing and analyzing,the characteristics and bottlenecks of the development of agricultural mechanization between and within regions were found,and it would provide decision making support for regional development of agricultural mechanization.【Conclusion】 Inter-regional and regional differences of agricultural mechanization are various,and the root reasons for differences are different as well.Governments should promote local agricultural mechanization on the basis of regional situation,comprehensive plan,concrete emphasis and gradient.


Man has created unique culture with his own activities,and cultural status is the status of human beings and human society,cultural development degree is a comprehensive measure of social progress.As an integral part of social culture or sub-culture,University culture is the spiritual power and the core competitive power of university development,which includes spiritual culture,material culture,system culture,environmental culture,and so on.To build university culture characteristic of education university a unique university culture,besides learning from experience of building the general university culture,we must start from the reality of education university,correctly handle the relationship between commonness and individuality,inheritance and development,and stick to the principles of seeking truth from facts,promoting development,reform and innovation.


We construct rotating hybrid axion-miniboson stars (RHABSs), which are asymptotically flat, stationary, axially symmetric solutions of (3+1)-dimensional Einstein-Klein-Gordon theory. RHABSs consist of a axion field (ground state) and a free complex scalar field (first excited state). The solutions of the RHABSs have two types of nodes, including 1S 2S state and 1S 2P state. For different axion decay constants fa, we present the mass M of RHABSs as a function of the synchronized frequency ω, as well as the nonsynchronized frequency ω2, and explore the mass M versus the angular momentum J for the synchronized frequency ω and the nonsynchronized frequency ω2 respectively. Furthermore, we study the effect of axion decay constant fa and scalar mass μ2 on the existence domain of the synchronized frequency ω. a firstname.lastname@example.com, corresponding author 1 ar X iv :2 10 3. 10 71 7v 1 [ gr -q c] 1 9 M ar 2 02 1


Brouardel [Ann. d. liyg., Paris, 1904, August) records the following unique case of self-inflicted injury :?A Paris policeman brought his wife, one morning, to the Tenon Hospital, along with her tongue, which he carried in a pocket-handkerchief. He stated that on his return home the previous day he found his wife up and attending to her household duties. She informed him that during the day she had had a violent attack of "nerves," and that in order to obtain relief from a feeling of suffocation she had put her hand down her throat and torn out her tongue. The organ was lying on a table by her side. Only slight haemorrhage followed the act. The doctor who examined her at the hospital found that the wound presented a regular surface, and that the whole tongue, from a plane posterior to the tonsils and at the level of the upper border of the epiglottis, had been torn away. The patient


In this paper, a novel nonisolated interleaved high step-up DC-DC converter is proposed based on the coupled inductor and voltage multiplier cell (VMC) methods. Due to the interleaved structure, its input current ripple is low. The low input current ripple and also high power efficiency make the proposed converter suitable for renewable energy applications like photovoltaic (PV) and fuel cell (FC) power generation systems. The windings of the coupled inductors are combined with VMCs to further increase the output voltage with a low power switch's duty cycle. This combination also leads to obtaining a flexible voltage gain that can be adjusted by coupled inductors' turns ratio and power switches' duty cycle. The voltage peaks over semiconductors are much lower than the output voltage. Therefore, low-rated semiconductors can be used for the implementation of the proposed converter, which can reduce the cost and volume. Generally, high voltage gain, low voltage, current stress of power switches, low input current ripple, high efficiency, common ground between the input and output ports, and a low number of elements are the main benefits of the suggested structure. The operation principle, steady-state analysis, and comparison with other converters are presented to show the advantages of the suggested converter. Also, a prototype is built, and the experimental results are presented to prove the theoretical analysis. This prototype is implemented with 200 W rated power, 25 V∼400 V voltage conversion, and 50 kHz switching frequency. Additionally, the efficiency is measured at 95.3% at the rated power.


The unexpectedly narrow structure of Rayleigh wing spectra from 5 to 50 cm −1 was detected using four-photon coherent laser spectroscopy. The observed features were compared with the IR water vapor absorption (from the HITRAN database) and with the spontaneous Raman spectrum in the vapor phase. The fairly good resemblance between our recorded four-photon spectrum and the pure rotational spectra of H2O molecules in the gas phase allows the suggestion that a discernible proportion of water molecules may exhibit virtually free rotation in the liquid phase. Copyright  2005 John Wiley & Sons, Ltd.


Abdominal tuberculosis (ATB) in children poses a diagnostic challenge because of its nonspecific clinical features, which often delay the diagnosis. Our aim was to present our real‐world experience and provide an insight into the presentation, pattern of distribution, and diagnosis of the disease.


A commercial mixture of α-, β-, γ-, and δ-hexachlorocyclohexane (-HCH) isomers has been tested for bioconcentration on early life stages of Oncorhynchus mykiss. Experimental results were elaborated by means of BIOCON, an interactive program for personal computers that provides bioconcentration factors (BCFs) and kinetic uptake and depuration coefficients as well as their standard deviations. The comparisons performed on a statistical basis evidenced few differences among the bioconcentration capability of larval stages, contrary to what was observed in previous studies with other chemicals. In the early juvenile stage, α- and δ-HCH are characterized by higher BCFs than the γ-isomer. The role of lipids is also investigated. The total lipid content seems to play a major role in influencing bioaccumulation parameters but cannot thoroughly explain BCF variability, which must be ascribed to other factors such as life stage and lipid composition.


Philip Beltracchi,1, ∗ Paolo Gondolo,1, 2, 3, † and Emil Mottola4, 5, ‡ Department of Physics and Astronomy, University of Utah Salt Lake City, Utah 84112, USA Department of Physics, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan Kavli Institute for the Physics and Mathematics of the Universe, The University of Tokyo, Kashiwa, Chiba 277-8583, Japan Theoretical Division, T-2, MS B283, Los Alamos National Laboratory Los Alamos, New Mexico 87545, USA Department of Physics and Astronomy, University of New Mexico Albuquerque, New Mexico 87131, USA


PURPOSE: To provide a method for efficiently producing D-arabitol, and a method for producing D-xylulose and xylitol using the method. CONSTITUTION: The method for producing xylitol comprises the steps of: producing D-arabitol in a medium by culturing a microorganism which belongs to the genus Metschnikowia, and can produce D-arabitol (e.g. M pulcherrima, M reukaufii, M bicuspidata, M. lutana, and M. zobellii) aerobically in a medium containing saccharide(s) as the main carbon source(s) to form D-arabitol in the medium, inoculating/culturing a microorganism which has an ability of producing D-xylulose from D-arabitol to form D-xylulose in the broth, and inoculating/culturing a microorganism which has an ability of transforming D-xylulose to xylitol to the broth containing D-xylulose to collect xylitol formed.


Alzheimer's disease is an increasingly prevalent neurological disorder with no effective therapies. Thus, there is a need to characterize the progression of Alzheimer's disease risk in order to preclude its inception in patients. Characterizing Alzheimer's disease risk can be accomplished at the population-level by the space–time modeling of Alzheimer's disease incidence data. In this paper, we develop flexible Bayesian hierarchical models which can borrow risk information from conditions antecedent to Alzheimer's disease, such as mild cognitive impairment, in an effort to better characterize Alzheimer's disease risk over space and time. From an application of these models to real-world Alzheimer's disease and mild cognitive impairment spatiotemporal incidence data, we found that our novel models provided improved model goodness of fit, and via a simulation study, we demonstrated the importance of diagnosing the label-switching problem for our models as well as the importance of model specification in order to best capture the contribution of time in modeling Alzheimer's disease risk.


The collected information on the enterprises of wood processing and wood-based panels industry was classified and summaried,analyzed the industry status quo,finally raized some suggestions on the industry development.


Sir, The discovery of the peptide hormone hepcidin and its central role in the regulation of systemic iron homeostasis is proved to be one of the major advances in hematology and iron metabolism field (Nemeth et al., 2004). The bioactive form of hepcidin is a 25-amino acid cationic peptide that synthesized, processed, and secreted predominantly by hepatocytes (Park et al., 2001). Through binding with the cell-surface iron transporter ferroportin and inducing its internalization and degradation, hepcidin regulates iron absorption, recycling, and delivery (Nemeth et al., 2004). Transcription of hepcidin is regulated by multiple stimuli, including anemia, hypoxia, and inflammation, erythropoietic activity, iron store, and mandatory signaling pathways [BMP (bone morphogenetic protein)-SMAD, JAKSTAT, and HIF-1 (Hypoxia-inducible factor-1) pathways] (Darshan & Anderson, 2009). Hepcidin synthesis is increased by inflammation or elevated plasma ferritin concentration and decreased in states of anemia, hypoxia, and iron deficiency and by erythropoietic activity. Hepcidin excess plays important role in anemia of inflammation, its deficiency mediates iron overload in most hereditary hemochromatoses and iron-loading anemias. Blood hepcidin level is also pathologically influenced by impairment of kidney or liver function. Accumulating data show hepcidin or prohepcidin, its precursor peptide, accumulate in end-stage renal disease or chronic kidney disease. Hepcidin or prohepcidin expression is lowered in patients with chronic hepatitis and liver cirrhosis. From October to December 2007, we determined serum prohepcidin levels and blood erythropoietin (EPO), IL-6, high sensitive C-reactive protein (hs-CRP), alanine aminotransferase (ALT), hemoglobin (Hb) concentrations in a group of 21 healthy adults. They comprised of 11 men and 10 women, randomly chosen from normal subjects visiting the health examination center of Nanshan hospital. The inclusion criteria were normal blood routine check, normal red blood cell count and shape, normal hemoglobin (Hb) level, normal hepatic function (ALT 45 U/l) with no viral hepatitis or other hepatopathy, and normal renal function [creatinine 1.2 mg/dl (106 umol/l)]. Exclusion criteria included presence of apparent or subclinical inflammatory diseases, female subjects within menstrual period, history of chronic diseases or recent drug taking (such as NSAIDs, glucocorticoids, or immunosuppressors) that might potentially influence body inflammation state and parameter assay. Serum prohepcidin, hs-CRP, and plasma IL-6 and EPO concentrations were determined with ELISA; others mainly by automated analyzer. The ELISA kits we used were, EIA-4644 Competition ELISA (DRG Intl. Inc., Marburg, Germany) for prohepcidin, Human CRP ELISA 1000 (ADI, Jersey City, NJ, USA) for hs-CRP, BMS213HS high sensitivity human ELISA (Bender MedSystems, Vienna, Austria) for IL-6, RE56011 Sandwich ELISA (IBL, Hamburg, Germany) for EPO. Continuous variables are presented as mean ± SD values. The Pearson correlation method was used to analyze the association of normal distribution parameters, non-normal distribution data by Spearman correlation method. A two-tailed P value of <0.05 was considered statistically significant. All computations were performed with spss 15.0 for Windows (spss Inc., Chicago, IL, USA). In this trial, the serum prohepcidin concentration was 153.7 ± 29.5 ng/ml; serum hs-CRP 89.3 ± 315.2 ng/ml; plasma IL-6 0.97 ± 1.43 pg/ml; plasma EPO 5.0 ± 6.8 mIU/ ml; Hb 136.48 ± 14.42 g/l; ALT 20.0 ± 10.5 U/l (Table 1). There was no significant difference of serum prohepcidin levels between gender and different age group (below vs. equal or above 30 years). Correlation analysis showed only EPO was positively associated with prohepcidin significantly (r = 0.494, P = 0.027, 95% CI 0.24 3.48, Figure 1). A nonsignificant but trend to negative correlation between hemoglobin and prohepcidin was observed (r = )0.379, P = 0.090, 95% CI )1.51 0.12). No significant relationship between prohepcidin with hs-CRP, IL-6, or ALT levels was found. And further by stepwise multivariate regression analysis, only EPO presented as a positive predicator for serum prohepcidin concentration (P = 0.014, 95% CI 0.569 4.179, determinate coefficient of regression equation R = 0.602). Earlier researches manifested that anemia and EPO administration could down-regulate hepcidin-mRNA LETTER TO THE EDITOR INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY


The d-th Veronese ring is the ring of polynomials such that the degree of every term is a multiple of d. We can represent these Veronese rings as the quotient ring of another polynomial ring. We are interested in the defining ideal of this quotient ring. The n-th symbolic power of a radical ideal I can be thought of as the set of polynomials which vanish up to order n along the solution set of I. Our research is concerned with the symbolic powers and the primary decomposition of the defining ideals of Veronese rings.


Inthispaper, preliminary design hasbeendeveloped tocontrol ajoint systemforanautonomous humanoidrobot. Motorscontrolling thevarious movements oftherobotwill track prespecified joint trajectories byusingnew controller, called quasi-linear minimalordercontroller to achieve accurate trajectory tracking. Thecontroller isminimal orderandisable to producedesirable results. The keyfactorlimiting the controller performance isthetradeoff betweenrateof convergence oftracking error. Thesystemisfeedback linearized andtheresultant dynamics ofthefeedback linearized system correspond toacertain class oflinear systems, whichmakesit attractive fortheapplication ofasimpler orderfeedback control designed onthebasis ofquasi-linear feedback theory. Underthis design, thepoleofthelead-lag compensator depends onthegain ofopenloopsystem. A simulink modelisdeveloped tomodel single jointinthebody.The designed controller notonly guarantees asymptotic tracking ofthedesired trajectories, but alsoensures thesafety. Thesimulation results showthatthenew strategy yields valid results. IndexTerms - Humanoid robot, joint system, quasi-linear control.


Conditions: Material = HDPE CM1, Mw=104kg/mol, Mn=50.2kg/mol, Polydipersity=2.07, Temperature = 175 degrees celsius, Piston speed = 0.044mm/s, Width of flow channels = 1.5mm, depth of sample = 10mm (hence 2D flow approximation is possible), Back pressure in the side arms = 5bar. For further details see:Hassell DG, Auhl D, McLeish TCB and Mackley MR, The effect of viscoelasticity on stress fields within polyethylene melt flow for a cross-slot contraction-expansion slit geometry, Rheologica Acta, 47, 821-834 (2008)


In recent years,International terrorist activities have shown the features of high frequency,decentralization of targets,high-tech,and relative youth of its members. Under the influence of international terrorism,domestic terrorists have caused several terrorist events by linking the inside and outside,the dark and light so that the anti-terrorism is gradually rigorous. In the complex national and international terrorism environment,the relative departments should firstly analyze the features and disciplines terrorism in depth,strengthen their terrorism awareness;build an antiterrorism information-centered operation mechanism and fight against terrorist forces severely.


The larval salivary gland secretion genes (Sgs-3, Sgs-7 and Sgs-8) at chromosome position 68C in Drosophila melanogaster, are developmentally regulated and coordinately expressed. Each gene codes for a component of the mucoprotein glue which is synthesized in the third instar salivary glands. Expression of these three genes is associated with the 68C intermolt puff present in the polytene chromosomes of the salivary gland secretory cells. Expression occurs only in the salivary glands of third instar larvae, and requires the steroid hormone ecdysterone. We show that synthesis of the 68C glue gene RNAs is prevented in larvae carrying trans-acting mutations within the Broad-Complex (BR-C), while a puff persists at 68C in these mutant larvae. We use the l(1)su(f)[superscript ts67g] mutation (which has reduced ecdysterone levels and also prevents 68C glue gene expression) and a mutation in the BR-C (nprl[superscript 3]) to study the cis-acting elements responsible for interaction with trans-acting factors by analyzing the protein:DNA contacts which occur upstream of the Sgs-3 glue gene during active synthesis, using in vivo DMS-footprinting. The proximal promoter can direct tissue- and stage-specific expression and is shown to possess three protein-binding domains. Comparison of contacts at these three domains between expressing and non-expressing tissues (including salivary glands from (l)su(f)[superscript ts67g] and nprl[superscript 3] mutant larvae) identifies a single binding domain responsible for controlling developmental expression of Sgs-3.

We also analyze the cis-acting sequences required for the chromosomal puffing associated with 68C glue gene expression. Examination of various fragments of 68C DNA reintroduced into the Drosophila chromosomes by P-element transformation identifies a region of 152 basepairs between Sgs-7 and Sgs-8 which is necessary, but not sufficient, to promote puffing. Only when this region is accompanied by an adjacent promoter element is there a puff. The insertion sites containing these reintroduced fragments fail to puff in mutant larvae; therefore, formation of the 68C intermolt puff requires the products of the su(f) and BR-C loci, and the puff at 68C in mutant larvae is not the same puff as that associated with expression of Sgs-3, Sgs-7 and Sgs-8.


The parametric array (PA) is a nonlinear transducer that generates narrow, sidelobe‐free beams of low frequency sound, through the interaction of high frequency pump waves. PA was suggested by Peter J. Westervelt, winner of the Lord Rayleigh Medal, at the same time this devise invention was underway in the Soviet Union made by Zverev and Kalachev. Remarks of PA applications for long distance ocean sounding is presented in the present paper. Experimental test of a high‐frequency PA was made on the Black Sea coast by Esipov et al., and investigations of powerful PA characteristics was performed in a ocean by Andebura et al., in 1990. Then large‐scale ocean vortices sensing at a distance of 1000 km was realized by Esipov et al. [Acoust. Zh., 40(1), 71–75 (1994)]. In both experiments, the transducer of R/V "Boris Konstantinov" was used with parameters: pump wave power W=20 kW, pump wave frequency f=3 kHz, parametric signal frequency F=230–700 Hz. Obtained results indicate the efficiency of PA application for ...


This thesis work involves the synthesis, composition, structure, electronic and opti cal analysis of nanostructured semiconductors and cluster assembled nanomatenals The mam studies have been made on three different systems having different aspects Studies have been made on (1) synthesis of mercury tellunde (HgTe) nanocrystallme semiconductors by electrochemical deposition technique and evaluation of size and composition dependant surface, structure and optical properties using Rutherford backscattermg spectrometry (RBS), particle induced X-ray emission (PIXE), trans mission electron microscopy (TEM), glancing angle X-ray diffraction (GXRD), Ra man scattering, X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), Fourier transform infrared (FTIR), optical absorption and photoluminescence (PL) techniques, (11) synthesis of HgTe-DNA complex nanocrystals (NCs) sys tems which have resulted unique structural and optical properties that depend upon DNA sequence specificity and (in) synthesis, surface and structural properties of low energy cluster beam deposited (LECBD) cluster assembled metal oxide (Se02) nanomatenals


We propose a new framework for calibrating parameters of energy functionals, as used in image analysis. The method learns parameters from a family of correct examples, and given a probabilistic construct for generating wrong examples from correct ones. We introduce a measure of frustration to penalize cases in which wrong responses are preferred to correct ones, and we design a stochastic gradient algorithm which converges to parameters which minimize this measure of frustration. We also present a rst set of experiments in this context, and introduce possible extensions to deal with data-dependent energies. 1. Description of the method Many problems in computer vision are addressed through the minimization of a cost functional. Typically, one is given a large, but nite, set (for example the set of pictures with given dimensions), and one tries to obtain an element x 2 which minimizes a given real-valued functional x 7 ! E(x). Most of the time, the energy is designed as a combination of several terms, each of them corresponding to a precise property which much be satissed by the optimal solution. For example, the cost function in 5], which is used to segment and smooth an observed picture, is the combination of three terms, one which ensures that the smoothed picture is not be too diierent from the observed one, another which states that the derivative of the smoothed picture should be small, except, possibly, on a discontinuity set, and a last one which ensures that the discontinuity set has small length. These terms are weighted 1


Five hundred ultrasonographically guided large‐core needle breast biopsies of solid masses were performed in 446 women. Histopathologic results were correlated with imaging findings. Ultrasonographically guided large‐core needle biopsy resulted in diagnosis of malignancy (n = 124) or severe atypical ductal hyperplasia (n = 4) in 128 lesions (26%). In the remaining 372 lesions (74%), ultrasonographically guided large‐core needle biopsy yielded benign pathologic results. Follow‐up of more than 1 year (n = 225), results of surgical excision (n = 50), or both were obtainable in 275 (74%) of the benign lesions. No malignancies were discovered at surgical excision or during follow‐up of this group of benign lesions. There were no complications related to large‐core needle biopsy that required additional treatment. Ultrasonographically guided large‐core needle biopsy is a safe and accurate method for evaluating breast lesions that require tissue sampling.


Basmati rice, also called the king/prince of rice landraces has very special values in Nepalese society as well as in other countries of Indian Subcontinent. With the objectives of collecting, analyzing and documenting Basmati related information in Nepal, we visited different sites; carried out key informant surveys; organized focus group discussions, online interaction and discussion meetings; requested all relevant offices/ persons/ stakeholders through phone, website, and letter to share information; organized high level official meeting, and Basmati rice expert meeting; documented video documentary and did online as well as library search. Because of its high market value at global level, many countries and organizations have been attempting to get intellectual property rights (mainly patent and geographical indication tag) on Basmati rice. India applied for GI tag to Basmati rice in the European Union (EU) in July 2018, and Nepal submitted opposition letter along with proofs and evidences of origin, diversity, cultivation and use values of Basmati rice on 9 December 2020. A total 133 Basmati type rice landraces are grown in 60 districts of Nepal. Basmati rice is traditionally grown, sold, and consumed in geographically localized areas of Nepal since ancient time. International and national scientists have defined lower altitude of Nepal as one of the centers of origin of Basmati rice. Many Nepalese basmati rice landraces have been characterized and evaluated using morphological traits, isozymes and DNA markers. Four basmati type of rice landraces have been registered in National Seed Board. Many community seed banks have maintained different types of Basmati rice landraces. National Agriculture Genetic Resources Center and International genebanks have collected more than 80 and conserved 68 basmati landraces. Basmati rice landraces have geo-linked traits. The historical culture of production, consumption and marketing of native basmati rice in Nepal should always be favored by both national and international rules and regulations. Nepal has ample and valid evidences to get geographical indication (GI) right on Basmati rice.


Introduction. The work contains a theoretical understanding of the problem of personal trajectories of education of teachers in additional inclusive education. Purpose setting. Work on the creation, implementation and improvement of the individual educational trajectory of schoolchildren and students with disabilities within the framework of an inclusive education model is the key condition for its success. Methodology of the study. This study is an attempt to implement a systematic approach to the study of problems in the practice of training modern teachers in the context of an inclusive education model. Results. The concept of an individual educational trajectory from the point of view of the task of high-quality training of a modern teacher in general and additional inclusive or inclusive education can be defined as an individualized (individual-specific) way for a person to search for and implement his personal, interpersonal and professional potential, his creative and reproductive, pedagogical and other abilities, implemented with the support and participation of a tutor, supervisor or other mentor, or completely independently (in the context of self-education). The created and implemented inclusive trajectory, being presented in the didactic and mentoring interaction of the teacher (subject teacher, class teacher/curator, or other tutor) and the student, requires work on its reconciliation, reflection, correction, etc. The activation of educational and professional activity of students with disabilities is associated with the formation and implementation of an inclusive individual educational trajectory as such a trajectory of personal, interpersonal and professional formation and development of a person, which is designed to solve the problems of his inclusion. It can take different forms. Conclusion. An educational trajectory that activates and creates conditions for the comprehensive development and inclusion of a person with disabilities in the community is formed and implemented under the condition of synchronization of the lines of personal, interpersonal and educational and professional improvement in general and additional inclusive education, harmonization of the space-time of education and the space-time of being of each person with disabilities as a student and future specialist. Such synchronicity and harmony is the result of conscious, multilateral and constant efforts of all subjects of education at all stages of development and implementation of the educational trajectory of the future teacher, up to reflection and correction of the educational route and its different stages.


The main objective of this paper is to prove Hilbert-type and Hardy-Hilbert-type inequalities with a general homogeneous kernel, thus generalizing a result obtained in [Namita Das and Srinibas Sahoo, A generalization of multiple Hardy-Hilbert's integral inequality, Journal of Mathematical Inequalities, 3(1), (2009), 139--154].


ARE I_AfiOR-MA\ AGEMENT PARTNERSHLPS FOR COMPETITIVENESS POSSIBLE IN AMERICA? The U.S. Auto Industry Examined r Lowell Turner September 1988 B R I E Working Paper a36 Prepared for delivery at the conference Industrial Relations i n Times of Deregulation, wenier-Rcimers-Stiiiung. Dad Uomburg, September 29-October I . 198H. A shorter, revised version of this paper is forthcoming i n Technology Review. The author would like to thank Paul Adler R u t h Milkman. Mike Parker. Annalee Saxenian. Peter ijnterweger. Harold Wilensky and John Zysman for critical leadings of an earlier draft. r


A new nonparametric ranked set sampling (NNRSS) procedure is proposed to estimate the mean of a population. The estimator based on NNRSS is compared with the estimators based on ranked set sampling (RSS) and median ranked set sampling (MRSS) procedures. It is shown that the relative precisions of the estimators based on NNRSS are higher than those based on RSS and MRSS schemes for unimodal symmetric distributions around the mean and the distributions with low skewness.


Heart failure (HF) is a common presentation in patients with type 2 diabetes mellitus (T2DM). Previous studies revealed that the HbA1c level is significantly associated with HF. However, little is known about the association between HbA1c variability and HF. We aimed to evaluate the association of mean and variability of HbA1c with HF in patients with T2DM. Using Diabetes Share Care Program data, patients with T2DM who had mean HbA1c (HbA1c-Mean), and HbA1c variability (tertiles of HbA1c-SD and HbA1c-adjSD) within 12–24 months during 2001–2008 were included. The cutoffs of HbA1c-Mean were set at <7%, 7–7.9%, and ≥8%. Hazard ratios (HRs) for HF during 2008–2018 were estimated using Cox proportional hazard models. A total of 3824 patients were included, of whom 315 patients developed HF during the observation period of 11.72 years. The associated risk of HF increased with tertiles of HbA1c variability and cutoffs of HbA1c-Mean. In mutually adjusted models, HbA1c-Mean showed a consistent dose-response association with HF, while the association of HbA1c variability with HF disappeared. Among patients with HbA1c-Mean <7%, the associated risk of HF in patients with HbA1c variability in tertile 3 was comparable to patients with HbA1c-Mean ≥8%. In conclusion, mean HbA1c was an independent predictor of HF and not explained by HbA1c variability. In addition to absolute HbA1c level, targeting on stability of HbA1c in patients with good glycemic control was also important for the development of HF in patients with T2DM.


We produced clean 3-ps-duration optical pulses from a bi-sectional GaInN laser diode with an external-cavity configuration. The peak power of the optical pulses was 3 W under passive and hybrid mode-locking at a 1 GHz repetition rate.


The essence of "Three F issue" is the beneficial relationship between farmers and other social beneficial subjects in the process of modernization. Currently, our country has already entered a period when industry began to re-feed agriculture. We should realize an equitable social development between urban and rural areas by constructing the rural public service system; we should adopt different ways to promote agricultural production, such as a transfer of labor, the process of farm produce and industrialized management, along with the development of township enterprises; we should realize the re-feeding of agriculture to promote its development by construction and compensation; we should promote agriculture along with the development of urban areas and the mutual help of the construction of small towns and the development of township enterprises.


The functional design of infrastructures is generally determined by considering not only the physical constraints of the location where the infrastructures are built but also the benefits those are going to be obtained. After infrastructures being constructed, the aforesaid functional design should be used as a basis to maintain further sustainability. During the service period of the infrastructures, the physical phenomena may be very dynamics that may affect the performance of the functional design. Under the normal and extreme condition, the functional design should be assessed continuously whether or not still performs as its previous condition, necessary analysis and update of related documents, e.g. the standard operating procedure are required.  However, a structured monitoring system program should accompany the assessment. This paper deals with the assessment of the availability and release of water of Tilong Reservoir after about two decades of the construction. Assuming that the reservoir characteristic remains unchanged, a reservoir routing program applying the conservation of mass was developed, water released data was collected and the inflow hydrographs were examined. Results of the reservoir routing in the form of various inflow hydrographs show that the average annual water availability of Tilong Reservoir is significantly lower compared to that from its designed stage. The annual water availability from year to year varied considerably. The distribution patterns of the inflow hydrographs along the one-year performance were also examined, their comparisons with the designed distribution pattern from the initial condition are analyzed and discussed. Further assessment on the currently available standard operation procedure including the rule curve presents necessary actions for further sustaining Tilong Reservoir.


In this paper, we examine the financing strategies of startup firms included in the Kauffman Firm Survey with a focus on the financing strategies of new technology-based firms. Our findings support the Pecking Order and Life Cycle theories, at least in the case of new technology-based firms. Our results reveal that technology-based firms used a higher ratio of owner provided financing and lower ratios of financing from other insiders or external debt than all firms during their startup year. Thus, they were more dependent on the entrepreneur's personal financial resources than new firms overall. In spite of this, however, our findings reveal that technology-based firms raised larger amounts of capital than all firms during their startup year. This was particularly true for growth oriented technology firms and technology firms with high credit quality. JEL Classifications: G31; M13; O30


Frequently corresponding to syntactic components, the Maximal-length Noun Phrase (MNP) possesses abundant syntactic and semantic information and acts a certain semantic role in sentences. Recognition of MNP plays an important role in Natural Language Processing and lays the foundation for analyzing and understanding sentence structure and semantics. By comparing the essence of different MNPs, this article defines the MNP in the Tibetan language from the perspective of syntax tree. A total of 6,038 sentences are extracted from the syntax tree corpus, the structure type, boundary feature, and frequency of MNPs are analyzed, and the MNPs are recognized by applying the sequence tagging model and the syntactic analysis model. The accuracy, recall, and F1 score of the recognition results of applying sequence tagging model are 87.14%, 84.72%, and 85.92%, respectively. The accuracy, recall, and F1 score of the recognition results of applying syntactic analysis model are 87.66%, 87.63%, and 87.65%, respectively.


The Ceraíma Project is located in the municipality of Guanambi, approximately 675 kilometres west of Salvador, the capital of Bahia State, Brazil (Fig. 1). The Ceraíma Project is geologically located in the domain of the Monzo-syenitic GuanambiUrandi batholith, which consist of multiple intrusions of syenitic, monzonitic, granitic and monzo-dioritic rocks (Rosa, 1999). The geological map of the Ceraíma Project performed by Terrativa is illustrates at Fig. 2. The units AFS-GNF, AFS-MAG and AFS are constituted by alkali feldspar syenite, and composed by the same main minerals, alkali feldspar, biotite and clinopyroxene. They differ by the proportion of these minerals and by the texture. The ALU unit is alluvion.


The characteristics of the media processor TI's TMS320DM642 HPI are described.The structural theory of PCI bridge—PCI2040 is introduced.A communication connection design between TMS320DM642 and PC/104+ is put forward,which is realized with PCI2040.This solution makes full use of the Host Port Interface of DSP to realize a high data transfer rate between DSP and PC/104+and enables the PC/104+ computer to read/write any memory unit of DSP in a real-time way.A design solution of traffic video supervisory system is given and the programming of the communication process is explained.


Heavy nuclei bombarded with protons and deuterons in the 1 GeV range have a large probability of undergoing a process of evaporation and fission; less frequently, the prompt emission of few intermediate-mass fragments can also be observed. We employ a recently developed microscopic approach, based on the Boltzmann-Langevin transport equation, to investigate the role of mean-field dynamics and phase-space fluctuations in these reactions. We find that the formation of few IMF's can be confused with asymmetric fission when relying on yield observables, but it can not be assimilated to the statistical decay of a compound nucleus when analysing the dynamics and kinematic observables: it can be described as a fragmentation process initiated by phase-space fluctuations, and successively frustrated by the mean-field resilience. As an extreme situation, which corresponds to non-negligible probability, the number of fragments in the exit channel reduces to two, so that fission-like events are obtained by re-aggregation processes. This interpretation, inspired by nuclear-spallation experiments, can be generalised to heavy-ion collisions from Fermi to relativistic energies, for situations when the system is closely approaching the fragmentation threshold.


We have developed an innovative liquid crystal display (LCD) which includes a resistive type touch screen system — integrated touch screen panel (iTSP). It can detect touch events and locate touch positions by measuring voltage at the contact point between indium tin oxide (ITO) coated color filter glass and ITO conductive isotropic film. iTSP shows not only better display qualities outside but also considerable decreases in weight and thickness compared to conventional resistive touch screen panel which consists of ITO glass and conductive film. In this paper, main characteristics of 7.0″ WVGA LCD Panel integrated with the touch screen function were presented and the optical characteristics also were discussed.


Background Gastric cancer is the second leading cause of cancer-related deaths, with a 5-year survival rate of about 20–25%. The ability to predict pathological response (PR) to neoadjuvant chemotherapy (NACT); hence, overall survival (OS) probability of patients can allow the clinician to individualize treatment strategies. We investigated the role of F-18 fluorodeoxyglucose PET-computed tomography (F-18 FDG PET/CT) in predicting histopathologic response and prognosis in locally advanced gastric cancer (LAGC) patients undergoing NACT. Methods F-18FDG PET/CT images taken before and after NACT, adenocarcinoma histopathology and operation pyesis reports of 43 LAGC patients were analyzed. Maximum (SUVmax) and mean (SUVmean) standardized uptake values, metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of lesions were measured before and after NACT. Changes in percentage were calculated for ΔSUVmax%, ΔSUVmean%, ΔMTV%, ΔTLG%, and cutoff values were determined by receiver operating characteristic curve analysis. NACT response in pathology pyesis was determined according to the College of American Pathologists classification. PR and OS were analyzed with Kaplan–Meier and Cox proportional hazards regression models based on cutoffs found with PET measurements. Results Cutoffs were ΔSUVmax = 33.31%, ΔSUVmean = 42.96%, ΔMTV = 30.38%, and ΔTLG = 28.14%, and all patients showed significance in PR and OS based on these cutoffs (all P < 0.01). PET/CT findings before and after NACT (ΔMTV > 30.38%, ΔTLG > 28.14%) predicted PR with 100% sensitivity and specificity. Multivariate analysis showed ΔSUVmean as an independent risk factor predicting OS (hazard ratio 0.348, 95% confidence interval 2.91–22.3, P = 0.03). Conclusions Metabolic parameters obtained with F-18 FDG PET/CT scanning before and after NACT in LAGC patients can accurately predict PR and OS.


Sebacic acid diesters have wide range of applications for the synthesis of basic oleo chemicals and oleo chemical derivatives. Specifically diesters of sebacic acid with the alcohols like isoamyl and isobutyl alcohol are important in this aspect. The present work aimed at preparation of these diesters in the presence of lipases from a variety of microbial origin. We have screened four commercial lipases e.g. 1, 3 specific RM-IM lipase (Source: Rhizomucor miehei), 1, 3 specific TL IM lipase (Source: Thermomyces lanuginosus), non specific NS40013 lipase (Source: Candida Antarctica) and non specific NS 435 lipase (Source: Candida Antarctica) for their ability to catalyze the synthesis of diesters with different alcohols. Different reaction parameters like lipozyme concentrations, temperature and substrate concentration were studied for this purpose by varying the mole ratio of acid and alcohol from 1:1 to 1:16. Rate of conversion increased with the increase in acid: alcohol molar ratio up to a certain level. Our results show that the maximum catalyzing action was observed for the enzyme NS 435 towards esterification reaction and due to higher productivity, this enzyme was successfully recycled for 10 times without any appreciable change in percent conversion which proves the admirable commercial viability of the process. Correspondence Sumit Nandi, Email: firstname.lastname@example.com, Ph.-09830548335/09804469759.


This paper describes how the self4eating effect is included in power device models which are used for circuit simulations. As examples the thermal characteristics of the power MOSFET and the reverse diode are presented. Self-heating is determined by the power dissipation and by the thermal resistance and capacitance of device and package. These parameters are extracted from the observed thermal behavior of the device. The thermal and electrical device characteristics are mathematidy formulated and implemented in the circuit simulator SABER.. Results show the significance of the self-heating effect.


BACKGROUND: TPI 287, a novel anti-microtubule agent of the taxoid class that readily penetrates the blood-brain barrier, is under investigation for the treatment of recurrent glioblastoma (GBM). A dose-escalation Phase 1/2 trial was designed to determine the maximum tolerated dose (MTD) and efficacy of TPI 287 in combination with bevacizumab. Initial results from the dose escalation stage of the trial are reported here. METHODS: Patients with GBM at first relapse after standard therapy without prior exposure to anti-angiogenic agents are eligible for enrollment. Bevacizumab is administered at 10 mg/kg as an IV infusion once every 2 weeks. TPI 287 is administered as a 1-hour IV infusion every 3 weeks. Employing a standard 3 + 3 design, dose escalation of TPI 287 is planned until a dose-limiting toxicity (DLT) is observed in order to select the recommended Phase 2 dose. MRIs are obtained at the end of every six-week cycle with response assessment via RANO criteria. RESULTS: As of June 2014, a total of 9 subjects have been enrolled in the first 3 dose-escalation cohorts (140, 150, and 160 mg/m2). No DLTs have been observed to date, and no drug-related grade 3/4 adverse events have been reported. Among the 7 patients evaluable for response, 3 achieved a partial response, and 2 had stable disease (1 confirmed, 1 unconfirmed). Four of these first 9 patients remain on study 39 weeks after start of the trial. TPI 287 dose escalation continues. CONCLUSIONS: Preliminary data to date indicate that TPI 287 is safe in combination with bevacizumab for the treatment of recurrent GBM. Evolving safety and efficacy results will be presented.


Effects of density on the heat transfer of adhesive-free corkboard during hot-pressing were examined by the advanced method of online temperature measurement.Results showed the changes of temperature in the central layer were divided into 4 stages: the short constant temperature stage,in which the temperature was constant or increased very slowly;the fast temperature rising stage,in which the moisture in the mat was not vaporizing;the constant temperature stage,in which the moisture vaporized,and the slow temperature rising stage,in which the moisture vaporizing process was near to the end.Along with the increase of density,the constant temperature period extended.The temperature-increasing rate of the central location temperature of surface and central layers of corkboard mat decrease coupling with the density increases,but the extents are different.Along with the increase of density the core layer vaporization temperature became higher,vaporization period of time extended.And the time of the central location reaching 100℃ is enlarging with the higher density.


New records and other interesting findings of shore flies (Ephydri - dae) from Slovakia are presented here. Two species (dorsata Sten- hammar, 1844 and Ochthera manicata (Fabricius, 1794)) were reported for a first time from Slovakia and another seven species ( Dichaeta caudata (Fallen, 1813), Hydrellia albilabris (Meigen, 1830), Limnellia quadrata (Fallen, 1813), Pa- racoenia fumosa (Stenhammar, 1844), Parydra (Parydra) aquila (Fallen, 1813), Pelina aenea (Fallen, 1813), and Pelina nitens Loew, 1873) were confirmed from Slovakia by complete and reliable records.


The water binding capacities of five cereal and three tuberous starches, as well as fourteen modified wheat starches were determined using a Differential Scanning Calorimetry technique. Of the native starches, the tuberous ones had the highest moisture binding capacities. The influence of amylose/amylopectin ratio on water binding capacity was examined using waxy maize, normal maize and high amylose maize starches and increases in amylose level were found to result in reduced water binding. Chemical modification caused a reduction in the water binding capacity of wheat starch presumably as a result of blocking water binding sites on the starch molecules. Pregelatinized wheat starch showed a higher water binding capacity than wheat starch as a consequence of the disruption of the internal structure of the granule.


Palliative care is defined as treatment that relieves the symptoms of cancer. From the perspective of the patient, reducing the burden of symptoms of cancer is one of the most significant accomplishments that can be achieved by health care professionals. From the perspective of those who care for the patient, suffering compounds the physical and emotional stress of witnessing the process of death. From a socioeconomic perspective, death is the most expensive process in health care; medical care at the end of life consumes 12% of the total health care budget, and 27% of the total Medicare budget is spent in the last 30 days of life. The National Institutes of Health in 2004 estimated that the overall cost for cancer was $189.8 billion. This included $69.4 billion for direct medical costs, $16.9 billion resulting from lost productivity due to illness, and $103.5 billion caused by lost productivity due to death. These costs reflect the toxicities of prolonged antineoplastic treatment strategies, and the continued need for analgesics and functional limitation related to unrelieved pain and disability from cancer. Antineoplastic therapy can be given with curative intent, or to prolong survival with the disease, or solely to relieve symptoms from cancer. When given with the intent to prolong survival with the presence of metastatic disease, antineoplastic therapy is often aggressive, and has defined and potentially serious side effects. When the cancer continues to progress and the patient's performance status declines significantly, a shift occurs in current clinical practice to administer treatment with the fewest side effects, recognizing that the patient will soon die from the disease. However, because of the inability to accurately predict prognosis and psychological barriers, this shift from aggressive treatment (which eventually becomes a futile attempt to prolong survival with cancer) to palliative care (which primarily targets the symptoms of cancer) is often delayed. Improving palliative care for cancer patients in the United States is one of the most pressing needs in oncology. Here we present an evidence-based socioeconomic evaluation of current clinical practice for the treatment of bone metastasis derived by the American College of Radiology (ACR) Appropriateness Criteria Expert Panel on Radiation Oncology.


Spin noise spectroscopy (SNS) of electrons in n-doped bulk GaAs is studied as functions of temperature and the probe-laser energy. Experimental results show that the SNS signal comes from localized electrons in the donor band. The spin relaxation time of electrons, which is retrieved from the SNS measurement, depends on the probe light energy and temperature, and it can be ascribed to the variation of electron localization degree.