This paper analyses discussions of the haka (popularly translated as 'the war dance of the Maori') in three performative sites in Aotearoa/New Zealand: a national Maori dance competition, touristic 'cultural experience' programs in Rotorua, and a secondary school in Wellington. The discussions demonstrate that this dance has come to represent a variety of 'identifications' for the speakers. However, while the haka elicits multiple, related and sometimes conflicting identificatory possibilities for Maori-identified discussants (albeit within a limited range of positions), this is not the case for a group of non-Maori men reminiscing about their boyhood performances at school sporting events. Through the comparison of discussions of these three performance sites, this paper argues that haka conversations reveal dynamic creativity in discourses of identifications (intra-indigenous, collective indigenous, and nationalist) of some speakers but not of others.


This paper examines Ben Jonson's comedies from the psychoanalytic point of view. The author argues that Jonson's comedies embody derivatives of his unconscious memories as well as of the fantasies they engendered. These derivatives appear in a recurrent sequential pattern of scenes in his work. Comedies embodying these patterns helped Jonson to keep his memories buried; when his effort at mastery broke down, he "acted out." The action and structure of the comedies also functioned as a continuing defense against depression, the syndrome that Freud in his day called "melancholia." Jonson's great failing as a playwright—his continuing inability to create lifelike, three-dimensional characters—resulted from his inability to detach himself sufficiently from the pressure exerted by his inner life.


The chlorine adsorbent is prepared by the method of once equal soakage.Under the conditions of ambient-temperature,space velocity ≤1 000 h-1,inlet chlorine volume fraction ≤400×10-6,outlet chlorine volume fraction ≤0.1×10-6,the chlorine-capacity of adsorbent can reach ≥11%.The parameters of thermodynamics and kinetics are got by analyzing experiment.The results show that the process which chlorine is adsorbed by adsorbent can be applied to the thermodynamics equation of Fueundlich and the kinetics equation of Dubbin-Radushkevich.At the same time,the reaction principle of adsorbent is concluded.


We propose a time-resolved technique based on coherent intradyne-detection to measure the short-term optical spectral line width and the long-term mode-frequency of a single-mode in a mode-locked laser. Aliasing inherent in self-delayed homodyne technique is avoided.


Asset growth has been shown to be negatively associated with future returns. Cooper, Gulen, and Schill (2008. Asset Growth and the Cross-Section of Stock Returns. Journal of Finance) argue that an aggregation of all asset growth components as total asset (TA) growth leads to the strongest association with future negative returns. Based on their study, the literature now employs TA growth as an umbrella proxy for "the growth effect." I hypothesize that not all types of growth imply negative future returns. Specifically, I show that growth financed by suppliers is positively associated with future performance and returns. Removing this growth component from TA growth makes it evident that the TA growth anomaly is simply a noisy manifestation of the net operating asset (NOA) growth anomaly. Consequently, I suggest caution when using TA growth to control for the growth effect.


Our country's theory of causality in criminal law should get out of the argument of certain or accidental causality.We may reference to other countries' theories so as to enrich our study which can be served for judicial practice.Based on the conditional relation,factual causality can be judged.And then we can evaluate causality in criminal law according to the theory of Corresponding Causal Relationship,and provide clear standards for corresponding causal relationship reference to the theory of Objective Imputation.


We report two new dramatically dusty main sequence stars: HD 131488 (A1 V) and HD 121191 (A8 V). HD 131488 is found to have substantial amounts of dust in its terrestrial planet zone (LIR/Lbol ≈ 4 × 10−3), cooler dust farther out in its planetary system, and an unusual mid-infrared spectral feature. HD 121191 shows terrestrial planet zone dust (LIR/Lbol ≈ 2.3 × 10−3), hints of cooler dust, and shares the unusual mid-infrared spectral shape identified in HD 131488. These two stars belong to sub-groups of the Scorpius–Centaurus OB association and have ages of ∼10 Myr. HD 131488 and HD 121191 are the dustiest main sequence A-type stars currently known. Early-type stars that host substantial inner planetary system dust are thus far found only within the age range of 5–20 Myr.


We have carried out a molecular-dynamics simulation of a two-dimensonal Lennard-Jones liquid near the triple point. We have compared some of the static- and dynamic-correlation functions with those of hard disks to study the effect of potential and with those of a three-dimensional triple-point Lennard-Jones liquid to study the effect of dimensionality. It is noted that while the behavior is qualitatively similar, there are distinct potential and dimensionality differences.


This paper illustrates how a combination of 2 relatively new analysis techniques for the construction industry- computer simulation and time-lapse photography-may be used to provide a construction estimator and planner with additional tools for determining the optimum method of earthmoving with loaders and trucks. The paper discusses the method of data collection using time-lapse photography and the production results obtained. It also discusses the development of the SIMSCRIPT computer simulation program based on the results of these field observations and indicates how a program of this type may be validated. The authors conclude that the results obtained should be helpful to contractors in their decision-making responsibilities.


In the recent years, many people have good look at fashion sunrise industry of TV Shopping Channel in Taiwan. In 2004, it created NT$30,000,000,000 dollars for Taiwan T-Commerce Shopping Channel. It can be predicted that it will reach NT$50,000,000,000 dollars in 2005 and NT$200,000,000,000 dollars in 2008. Besides, a study about consumers' behaviors in Internet from III indicated that more than 40% people always browse Online Shopping websites in Taiwan and spend NT$10,000 dollars average per year. For 2001 to 2004, Online Shopping website will promote the position from 6 to 2. It shows that online shopping still popular for people in Taiwan.
In this study, we used a 2*2*2 experiment design to examine the effect of promotion types and promotion situations on consumer's purchasing intention. In addition, we also examine the moderating effect of TV Shopping and Online Shopping.
The results indicate that the promotion types (monetary/nonmonetary) and promotion situations (Time Limited/Amount Limited) are not significantly affect consumer's purchasing intention. The interaction effects of promotion situation and TV Shopping/Online Shopping have significant difference on purchasing intention. Contrast to Online Shopping, TV Shopping has higher purchasing intention in promotions of Time Limited. It means that TV Shopping/Online Shopping have a moderating effect.


In order to solve the problems existing during the development of aerospace real-time embedded software, the process models of software development based on software engineering are studied and a set of methodology is put forward to support the basic steps and each stage of embedded software design. And an aerospace real-time embedded software developing platform based on this methodology is realized. This platform is now in the using stage of the project.


Abstract Populations of the South American sea lion (Otaria flavescens) were decimated throughout its range along the Atlantic coast. Responses to this decline have been different in different parts of the species' distribution range. Some stocks are still decreasing, some remain stable, and some are recovering slowly. In the Southwestern Atlantic, sea lion populations are now increasing. However, 50 years after the cessation of hunting these populations have not recovered to the levels they had before exploitation, with the recovery process occurring at the same time as increasing development of human coastal activities. The aims of this study were to present recent information on abundance and trends in the southern Patagonian population of sea lions and to test the hypothesis of population expansion with a particular recolonization process. Results showed that there was an increase in the number of sea lions in all colonies and a change in the social composition of nine colonies, but no new breeding colonies were found. The population trajectory of O. flavescens from southern Patagonia was similar to that observed in the rest of the South Atlantic populations, but the recovery and recolonization processes are still in progress. Here we discuss possible explanations of which factors could have delayed the recovery within the Southwestern Atlantic stocks.


The aetiological agents of the abdominal swelling affecting farmed larvae of gilt-head seabream, Sparus aurata L., were studied. Four Vibrio strains were isolated from larvae of S. aurata affected by this disease, and all strains reproduced the disease in healthy larvae under controlled infection experiments, producing a significant increase of the mortality rates compared to the control (non-inoculated larvae). Several enzymatic properties, which can act as .virulence factors, were demonstrated both in the extracellular products (ECPs) and In live cells of the strains tested. Histopathological examinations of the infected fish larvae revealed important changes of the anterior intestine and liver characterized by a marked hyperthrophy of the intestinal epithelium and hepatocytes, and by a separation of the mucosal and submucosal layers in the digestive tube. These histological alterations were associated with the constant presence of cocobacillar bacteria in the anterior intestine and in the liver. However, the precise pathogenic mechanisms of the strains tested have not been completely elucidated yet.


Kyes and Strauser 1 have recently reported the inhibition of anaphylactic shock in pigeons by the intravenous injection of heparin 45 minutes preceding the shocking dose of antigen. They state that it is their belief that many of the symptoms of anaphylactic shock are the result of the formation of fibrin aggregates, and that if the formation of these aggregates be inhibited by a suitable reagent the symptoms will be reduced or eliminated. In view of the striking results of these workers with pigeons, it seemed to us that it would be worth while to determine the effect of heparin on anaphylactic shock in guinea pigs. The animals were sensitized to horse serum twenty days before testing. Eight controls were tested for efficiency of sensitization, 6 of these dying with classical antemortem symptoms and showing the typical post mortem picture. Two animals exhibited symptoms of severe shock but survived. The guinea pigs receiving heparin were given 5 mg. of heparin in physiological salt solution intracardially for each 100 grams of body weight. The results obtained with these animals are shown in Table I. As shown in the table, two of the heparinized guinea pigs receiving shocking doses of serum exhibited classical symptoms of shock, one of them succumbing with typical post mortem findings. It may be recalled that Kyes and Strauser report that 1 of 12 heparinized pigeons showed transitory symptoms. We do not feel that there is any relation bettyeen the size of the shocking dose and the occurrence of severe syniptonis in the heparinized guinea pigs, since some of the animals showed slight or no syniptonis, after receiving the same amount of sertini as that given to those which exhibited shock.


Community college,the biggest part of American higher education,makes a great contribution to economic and social development.There is a close relationship between the peculiar curriculum setting and the great achievement of American community college.This paper tries to analyze the commonness of curriculum setting of American Community college,expecting giving some suggestion to our high vocational colleges.


Typography: A Very Short Introduction offers a broad definition of typography as design for reading, whether in print or on screens, where a set of visual choices are taken to make a written message more accessible, more easily transmitted, more significant, or more attractive. Considering the development of letterforms and the shapes of letter we use, it discusses the history behind our modern day letters and fonts, before considering the issues behind key typographic decisions, and the differences between printed and on-screen typography. Presenting any piece of typography as a fundamental design choice, this Very Short Introduction introduces the options available today, and explores the reasons why key typographic decisions are made.


Is it possible that critics of burgeoning anti-homosexuality legal frameworks in several African countries are wrong? Could it be argued that defenders of these frameworks are also wrong? Paradoxical, it seems, but both questions could be answered affirmatively – and for very good reasons. The claim that Africa's homosexuality prohibitory frameworks constitute a violation of human rights can be faulted on at least two grounds. First, there is no international law according recognition to homosexual sex or marriage or any other homosexual-specific interests trumpeted as rights. Second, the criticism, at least implicitly, denies the existential foundation of African concept of human rights. Yet, Africa's position is not, by any means, unassailable. By unreflectively entrenching Western-style constitutionalism into its post-independence sociopolitical and legal order, Africa has significantly whittled, if not outrightly suffocated, the force of its indigenous human rights ideology. Therefore, it cannot, without adequate justification, rely on this ideology to rescue itself from its current legal feud with the West. Would argument centered on colonial imposition suffice? Exploring these issues is the subject of this paper.


Since 1991, Ethiopia's record of economic growth has been very impressive. This paper critically examines the role of policies and institutions in addressing the developmental challenges of urban centres in Ethiopia. The paper highlights the importance of improving the quality of institutions and governance to consolidate the developmental gains of the past years and work towards further progress. Development and good governance activities in Ethiopian urban centres have been identified as propriety and are being implemented taking the country's urbanisation level and growth into account. As part of policy intervention in addressing the challenges of urban development in the country, activities such as investment promotion, improvement of governmental services in land and infrastructure, job creation, and housing provisions have been carried out. As a result, large and medium urban centres have exhibited a remarkable growth in construction, manufacturing, and tourism sectors. Moreover, job creation for the urban workforce has proliferated. The housing development programme has helped, besides creating job opportunities, the low and middle income urban dwellers to own property and have equitable wealth redistribution.


Introduces a distribution feeder relay smart in 10kV smart distribution network and equipment composition.A detailed description of the principle and equipment protection scheme,basic functions and principles on recloser and section switch.This mode is put into trial operation and the effect is satisfactory.Such kind of results show that the methods proposed in this paper are reliable and sensitive.


An overview was given of the development process and design philosophy of a newly-developed ГТЭ-65 type power-generation gas turbine,including the choice of the parameters for the thermodynamic system,design and features of the three major components-compressor,combustor and turbine,models and test rig tests for the main components,possibility of their applications as well as further upgrading approaches. By making use of the currently available achievements and employing a plotting mode at a proportional range,a full-scale simulation design was adopted for the compressor. According to DLN (dry low NOx) or DLE (dry low emissions) theory and by meeting various conditions for achieving low-emission combustion of the fuel,designed was a low-emission annular combustor. Through a comparison of various versions,the four-stage turbine design was finalized. Apart from the rotating blades in stage No.4,all the turbine blades were cooled. The ГТЭ-65 type gas turbine is regarded as a medium power one meeting modern"F"class technical level and can be used for both simple cycle gas turbine power plants and gas-turbine-based steam-gas combined ones,applicable for not only basic load operation but also semi-peak and peak load one.


The obscurantist Hellenistic poet Lycophron referenced the initiation of Heracles as a beast suckling the breast of the goddess Hera. This was the event that was the mythological origin of the Galaxy and of the lily flower that incarnated the same deifying essence as the celestial milk of the goddess and it was the etiology for the domestication of felines. As the Lion of Nemea, Heracles was the greatest of the wild cats. The lily was an analogue of a sacred mushroom, as the narkissos of Persephone's abduction by Hades. The event of the lactation of Heracles is depicted on four Etruscan mirrors and a Faliscan-Hellenic red-figure krater. The deifying milk-flower of the goddess was a ritual of adoption into the family of the celestial deities, that Hera performed also with two other bastard sons of Zeus, Hermes and Dionysus. As the beast being initiated, Heracles became a wolf. Like the motif of the domestication of the cat, the lycanthropy of Heracles involves the whole family of canines, from the domesticated dog to its wilder antecedents in the wolf and its analogue as the fox. The lycanthropy initiation is a bacchanalian rite of rootcutters and is a motif of warrior brotherhood widespread among the Indo-European peoples.


Intrusive vivid images of future catastrophe ("flashforwards") are important in social fears, like performance anxiety. Previous studies in healthy volunteers found that eye movements reduce vividness and emotionality of negative mental images of past events and future–oriented events. This study tested whether eye movements reduce image vividness and emotionality in students with performance anxiety. Participants (N = 29) imagined two feared future events related to performance anxiety during six 24 s blocks per image: one image was accompanied by eye movements, the other was not. Image vividness and emotionality were assessed before and after these blocks. Relative to the eyes stationary condition, eye movements resulted in a significant decrease in image vividness, and a trend was observed for reduced emotionality. The findings add to earlier experimental findings on the benefits of dual-tasks during mental imagery, and suggest that eye movements and related procedures may be helpful in the treatment of performance anxiety.


The Italian writer Beppe Fenoglio(Alba, 1922-1963) is one of the most representative authors in the world of modern literature.
His autobiographical...


Although advances in cardiopulmonary resuscitation (CPR) have increased the likelihood of achieving return of spontaneous circulation (ROSC) after cardiac arrest (CA), >50% of initially resuscitated patients die before hospital discharge. Based on emerging evidence that a systemic inflammatory response exacerbates post‐ROSC injury, we recently tested the efficacy of allogeneic mesenchymal stem cell (MSC) administration early after ROSC in a porcine model of CA. Initial results indicate that MSCs attenuate post‐ROSC cardiac dysfunction, but it is unclear if these protective effects extend to the brain. Accordingly, the objective of this study was to determine if systemic allogeneic MSCs reduce post‐resuscitation neuroinflammation in swine.


The purpose of this study is to find out the Criminal Law aspects of forcibly taking the corpse of suspect/ probable Covid-19 patients in Hospitals. Efforts to forcibly taking the corpse of suspect/probable Covid-19 patients by family continue to occur in a number of areas, often by mobilizing masses. Hundreds of people came to the hospital to forcibly taking the corpse of Covid-19 patients who had just died. There are so many cases of forcibly taking the corpse of suspect/probable Covid-19 patients that have occurred in Indonesia, but no legal action has been taken by law enforcement officials to take action against and detain the perpetrators of forcibly taking the corpse of suspect/probable Covid-19 patients. This caused the absence of legal certainty, both legal protections for the Hospital and for the patient's family.


Abstract Our work as educators does not match the scope, scale, and urgency of the challenges we presently face and that our descendants will confront through the centuries of the "long emergency." There are many reasons for this, but most important is our tendency to overlook the hard reality that the use and disposition of land, air, water, forests, oceans, minerals, energy, and atmosphere are inevitably political having to do with "who gets what when and how." In other words, we do not have an environmental crisis as much as massive failure of political institutions and governments to foresee and forestall what has grown into the "long emergency."


A critical issue for complex software architecture design is modeling and analysis of dynamic architecture.This paper argues for an approach to specification of potentially unbounded dynamic structure based on Wright,an architecture description language.To support recursion mechanisms in software architecture specification,it identifies the concepts of composite connector and dynamic role,and illustrates how it can be used to create dynamic extension of structure.It provides mechanisms for designing dynamic architecture in an incremental way,and is available for architectural connectors reuse.


This paper presents a study of the role of middle managers in the knowledge transfer related to a person-centered management and care approach at a physical rehabilitation center. This qualitative research comprises a multi-case study, representing the six middle managers of the organization studied. The main findings generated by this research indicate that despite top management's efforts to disseminate a person-centered approach throughout the organization, the knowledge transfer process mainly depends on the absorptive capacity of middle managers. When middle managers have the capacity to absorb the person-centered approach, often because it is compatible with their values and current practices, this capacity is expressed mainly through their behavioral exemplarity. The results of the study also engender an intervention model illustrating the key role of middle managers in the transfer of a person-centered management and care approach. The model includes macro- and micro-contextual elements that facilitate the transfer.


Fifth-generation (5G) New Radio (NR) with non-standalone (NSA) operation, i.e., 5G NR NSA, which enables 5G NR deployments using existing the fourth-generation (4G) mobile systems have been introduced to diffuse 5G mobile systems. With the same configuration as a heterogeneous network (HetNet), 5G NR NSA deployments combine with macrocells by 4G and picocells by 5G in the same coverage. The use of millimeter wave bands in 5G NR is expected to achieve higher data rates because the available amount of signal bandwidth is enormous. Therefore, multiband HetNets with picocells operating at millimeter wave band can increase the system capacity and/or achieve higher data rate. To compensate for the large signal path-loss due to the use of millimeter wave band, we have proposed sectorized picocells with three-dimensional beamforming (3D-BF) in HetNets. In this paper, we investigate the transmission performance of multiband HetNets with sectorized picocells with 3D-BF operating at 28 GHz band in multipath fading channels based on tapped delay line models. Using system-level computer simulations, we clarify the average and 5-percentile user throughput of the HetNet using three-sector picocells with 3D-BF operating at 28 GHz band, whose bandwidth is 10 times wider than that of the macrocell operating at 2 GHz. We also clarify that the proposed method can increase the use rate of high-order modulation scheme in the downlink modulation and coding schemes.


Identification of different perfumes is significant to perfume industry, since it can help distinguishing genuine perfumes from imitation ones. In this paper, the Light Gradient Boosting Machine (LightGBM) and a prepositive dimension-reduction method were employed to identify four different perfumes, based on the response data of an electronic nose system. The candidate prepositive feature-dimension reduction methods are the principal component analysis (PCA), local linear embedding (LLE), and maximally collapsing metric learning (MCML) methods. After the feature-dimension reduction, as a recently presented classification method, the LightGBM was used to classify the features with reduced dimensions and output the identification results. Extensive experiments were conducted to evaluate the perfume identification performance. Experimental results show that, when the feature-dimension of perfume data was reduced to thirteen by the PCA, the ten-fold cross-validation identification accuracy of the LightGBM was up to 92.75%, which is higher than those obtained when LLE or MCML was used.


Tomato productivity and quality generally relies upon the genotypic and environmental interaction. Varietal assessment plays a significant role in specifying of a potential variety for a specific ecological zone and its adaptability to different soil texture. Different tomato genotypes i.e Red Ruby, TM777, TM1701 and TM1702 were transplanted from 6 March to 27 March at interval of seven days during 2018 at Dargai, district Malakand Khyber Pakhtunkhwa. Among the tested genotypes of tomato, the genotype TM1702 attained highest plant height, stem diameter, days to first flowering, highest number of flowers plant, number of fruits plant, individual fruit weight, fruit length, fruit diameter, fruit volume, total soluble solid, fruit juice pH and higher yield as compared to other genotypes of tomato. Similarly, the seedlings transplanted on 13 March significantly improved the morphological, yield related traits and quality attributes of tomato. It could be concluded that genotype TM1702 improved most of the studied attributes of tomato as compared to genotypes Red Ruby, TM777, TM1701 respectively. Similarly, tomato seedlings transplanted on 13 March was found best time of transplantation for the quality production of tomato under the climatic conditions of Dargai, district Malakand.


Rigorous quantum dynamical calculations have been performed on the ground 1 1A' and first excited 1 1A" electronic states of the title reaction, employing the most accurate potential energy surfaces available. Product rovibrational quantum state populations and rotational angular momentum alignment parameters are reported, and are compared with new experimental, and quasiclassical trajectory calculated results. The quantum calculations agree quantitatively with experiment, and reveal unequivocally that the 1 1A" excited state participates in the reaction.


Aliens — Expulsion of — Reasons for Expulsion — Judicial Review — Privileged Aliens — Alien Married to a National.


Development of Water Resource Utilization has close relationship with all knowledge (multidisipliner) such as social, economic, cultural, politic and even other pratical knowledge as well. Therefore, the success of this activity is really determined by involment of all related parties of "Stakeholders" who have same interest, in the positive puspose (pro) and negative (contra), including broad society. Social involment in utilizing water resource is really needed. This social involment program for water utilization actually has been well developed with the clear target, the main objective is to maintain the relationship with associated farmer included in association of farmer who utilizes water (P3A) for single, collective or main level as the main organization of farmers in using water for their irrigation. In order to gain better achievement, it is necessary to provide conducive, continous and intensive guidance that must be supported by all related parties or stakeholders, such as government, private and social organization as well as higher educational institution. By having partnership and participation of interested society, the utilization of water resource can be well conducted to get best result


The article assesses the agricultural production results in three regions of the Russian Federation: Irkutsk oblast, Republic of Buryatia and Zabaykalsky Krai, which are included in the Baikal Region. The agriculture functioning conditions in the Baikal region are considered. The specifics and problems of this economic sector development are revealed for all three regions.


A field experiment was conducted in a sandy loam soil during kharif season, 2012-2013 at Rajiv Gandhi South Campus, Barkachha, BHU, Mirzapur, Uttar Pradesh, India to find out the effect of different rate of sulphur sources on growth, yield and quality of sesame (Sesamum indicum L.) grown in the alley space of guava (Psidium guajava L.). The experiment was laid out in a randomized block design with 3 replications and three sources of sulphur viz. single super phosphate, gypsum and elemental sulphur and three levels of sulphur viz 15, 30 and 45 kg ha with control. The total treatment combination for all the levels were ten (T1-Control, T2-15 kg Sulphur ha -1 through SSP, T3-15 kg Sulphur ha -1 through ES, T4-15 kg Sulphur ha -1 through gypsum, T5-30 kg Sulphur ha -1 through SSP, T6-30 kg Sulphur ha -1 through ES, T7-30 kg Sulphur ha-1 through gypsum, T8-45 kg Sulphur ha-1 through SSP, T9-45 kg Sulphur ha-1 through ES, T10-45 kg Sulphur ha-1 through gypsum). The crop was fertilized with recommended dose of NPK of 60:30:30 kg ha. Results revealed that application of 45 kg S ha through elemental sulphur recorded the highest plant height, number of branch plant , dry matter accumulation, capsules plant, seeds capsule, seed weight plant and test weight, seed yield, stover yield, biological yield, harvest index, protein content per cent, oil content per cent, carbohydrate per cent, total nutrient uptake and available nutrient in soil. It was significantly superior over 45 kg S ha through gypsum over rest of the treatment. The highest net monetary return (Rs. 24921.27 ha) and Benefit: Cost (B: C) ratio (1.52) was obtained when 45 kg sulphur was applied through elemental sulphur this was also found to be best treatment for sesame.


Background and objective: Experimental and few clinical studies have indicated great potential of stem cell treatments as both a causal and symptomatic approach for the treatment of male erectile dysfunction (ED). We investigated the effect of a one-time injection of stem-cell derived bioactive molecules in patients with self-reported ED.

Materials and methods: Twenty self-referred male patients with at least one-year history of ED received a one-time intra-penile injection of acellular stem cell-derived bioactive molecules. ED was evaluated by the International Index of Erectile Function questionnaire (IIEF-5), and quality of life was assessed by the Short-Form-36 questionnaire, (SF-36) at baseline and at 6 months. Six male patients with ED, who received a similar injection using saline served as a historic control. Primary outcome was erectile function as measured by IIEF-5 scores. Secondary outcomes were quality of life, assessed by SF-36 questionnaire.

Results: IIEF-5 scores improved from 12.9 ± 4.47 at baseline to 18 ± 3.37 at follow-up (p < 0.05). No significant difference of IIEF-5 scores were observed in the historic controls during the observation period (11 ± 2.53 at baseline vs 10.67 ± 3.5 at follow-up; p > 0.05). Patients, who received stem cell injections, demonstrated significantly enhanced IIEF-5 scores compared to the historic control (p < 0.05). Quality of life scores were significantly improved (role limitations due to physical health issues 56.25 ± 42.82 at baseline vs 68.75 ± 40.45 at follow-up, p < 0.05, energy 51.57 ± 19.33 at baseline vs 57.75 ± 12.3 at follow-up, p < 0.05, emotional wellbeing 56.32 ± 16.28 at baseline vs 68.1 ± 11.73 at follow-up, p < 0.05, and social functioning 67.5 ± 23.79 at baseline vs 76.25 ± 18.98 at follow-up, p < 0.05).

Conclusions: A one-time intracavernous acellular stem cell-derived bioactive molecule injection improves IIEF-5 scores and quality of life in men with ED in this small pilot phase study (ClinicalTrials.gov Identifier: NCT04684602).


In order to acquire information on sorptive systems suitable for predictive and design applications, it is necessary to gather and analyze data in bench or prototype reactors, the most common types being batch and packed column. In this paper, data from both types of reactors are presented and contrasted for the case of two trace elements, cadmium and chromate, sorbing to a granular form of iron oxide. The granular oxide was developed in conjunction with the ALCOA Laboratories specifically for use in column reactors. Data are analyzed using a surface coordination chemical approach and film transfer, surface and pore diffusion transport models. Governing coefficients are extracted using nonlinear optimization techniques which provide an objective interpretation of the data without the errors introduced by various linear transformations or analysis bias. Results indicate that both experimental techniques are capable of accurately measuring the equilibrium coordination constant for sorption reactions, however batch estimates for the total sorptive capacities are consistently lower than column estimates, which range from 1.1 mg/g for Cd to 3.3 mg/g for CrO[sub 4]. In addition, when column adsorption and desorption data are taken together, it is possible to obtain reliable estimates of rate-controlling parameters. This is not generally possiblemore » for batch systems under conditions representative of those encountered during environmental control. 22 refs., 6 figs., 1 tab.« less


Students enter graduate school with a primary species of interest and may have little to no desire for comparative and collaborative work. Indeed, intent focus on a single species is critical to their development as subject matter experts. But, working collaboratively with other graduate students and faculty in a secondary or tertiary species can be immensely beneficial to their education and growth. Upon graduation, whether in academia or industry, young professionals must collaborate with their colleagues in order to be successful. Commonly, this means working with others who are not directly involved in their area of focus. Developing these skill sets in graduate school promotes a more well-rounded applicant. Additionally, upon graduation, students may find their "perfect" position is not available. Working across multiple species affords them the opportunity to apply to a multitude of jobs that would otherwise be unavailable in a single species program.


Abstract Objective: To assess utility of cortical surface area as a measure of disease progression in multiple sclerosis (MS). Methods: We measured two-dimensional flattened cortical surface area on high-resolution magnetic resonance imaging (MRI) scans obtained in 15 subjects with clinically definite MS and ten normal subjects. Results and discussion: Single hemisphere cortical area was reduced in MS patients compared with controls (96,451 versus 71,710 mm2). We found no significant relationship of cortical surface area to disability or disease duration. T2 lesion load was negatively correlated with two-dimensional cortical surface area (r=−0.62). Conclusion: Cortical surface area is decreased in MS and may be a useful measure of disease progression.


On September 4, 2007 the United States Court of Appeals for the Ninth Circuit issued its much-anticipated decision in Cascade Health Solutions (fka McKenzie- Williamette Hospital) v. PeaceHealth,…


Objective The paper was to explore the characteristics of forensic psychiatric expertise in recent 40 years Methods A comparative study was coducted among 575 cases from 1960 to 1979(A) and 1 274 cases from 1980 to 1989(B) and 936 cases from 1990 to 1997(C) Results As date develop, the age was younger, the percentage of the females were increased , the cases associated with politic appeared to decrease (A:50 09%;B:4 24%;C:0 96% P 0 01) but the cases which associated with finances、sexual victims、mental injury and value of mental injury、sexual self defense et al, were increased ( P 0 01) In expertise diagnosis, the percentage of schizophrenics decreased (A:61 22%;B:37 83%;C:39 21% P 0 01), but there was a little difference between B and C groups The percentage of cases with value of responsibility were increased (A:14 29%;B:88 63%;C:99 13% P 0 01) Conclusions The research shows that with the development of society, politics, economy and culture, some characteristics of forensic psychiatric expertise are changed and expert testimony tends to be more legalize


Monolithic microfluidic reactors for the safe, expedient, and continuous synthesis of products involving unstable intermediates were fabricated and assessed. The formation of diazonium salts in anhydrous conditions and their subsequent in situ chlorination within microfluidic channels under hydrodynamic pumping regimes is presented. Significant enhancements in yield were observed due to enhanced heat and mass transfer in microfluidic systems. Analysis performed using off-line GC and GC−MS was compared with on-line, on-chip Raman spectroscopy for the direct determination of analytes.


Physical layer (PHY) security has become an emerging area of research recently. Wireless networks use unguided medium as communication channels, so gathering wireless data transmission is easier when compared to traditional cable systems. With the rise of new security challenges, many different solutions have been offered and are being developed. However, maintaining security in wireless networks still remains a challenge. Secure transmission techniques in these networks are discussed throughout this chapter. PHY security measures, the secrecy rate, the secrecy capacity, and the outage secrecy rate are introduced. Security needs of wireless networks are discussed and the related common attack types are described. Main countermeasures that are proposed to prevent these attacks are also presented with both practical and theoretical perspectives.


Applying nitrogen fertilisers in legume species has been subjected to scientific research due to the efficacy of these fertilisers on yield (symbiotic atmospheric nitrogen fixation). In general, applying high rates of nitrogen fertilisers on legume species does not correlate directly with green matter production because these species take the necessary nitrogen from the atmosphere. This feature is specific also to bird's-foot-trefoil, which fixes important amounts of atmospheric nitrogen during vegetation. This paper presents the impact of the interaction between organic and mineral fertilisers on bird's-foot-trefoil within a bifactorial experiment. Differences in yield at both unilateral effect of the factors and at that of the interaction of the factors are statistically ensured. Keywords: common bird's-foot-trefoil ( Lotus corniculatus L.), organic and mineral fertilisers, dry matter


A vector lattice W is boundedly complete when each subset {aj:j ∊ J} of W which is bounded above by an element of W has a least upper bound in W. The least upper bound of {aj:j ∊ J} is denoted by and the greatest lower bound by whenever these exist.


Adult consumers with serious mental illness (SMI) die 25 years younger than other Americans. Considerable limitations are evident in existing data sets that inhibit our ability to fully disentangle the underlying excess mortality in these populations. To date, it has been necessary to use multiple surveys to examine these relationships as no available data sets combine high-quality data including psychiatric diagnosis, health risk behaviors, medical comorbidity, medical and mental service use, and quality of care. It is critical that medical and mental health surveys each move toward including more robust information on the corresponding comorbidities and use of services and that each begin to incorporate longitudinal designs. This article addresses the need for data on mortality, morbidity, and services. It discusses the availability of state mortality data, reviews the data provided by numerous national and state data collection instruments, and provides a case study of Maine's integrated data analysis efforts. Finally, our recommendations to improve these data are organized into two sections: proposed actions by the Substance Abuse and Mental Health Services Administration and proposed actions by other federal and state entities.


In our daily life, we face with decision-making and treatment choice, which, according to our ability to choose reliable sources and evidence-based literature allows us to select the best diagnostic and therapeutic alternative for our patients. Publications in medical literature have increased over the years, and systematic reviews (SRs) have become progressively popular in medicine. Clinicians read them as an efficient manner of keeping up-to-date with their content area; they are a useful starting point for guideline development, helping to improve clinical practice (1, 2).


Objective:To establish a method for the determination of magnolin in Magnolia sprengeri Pamp.Methods:HPLC method was used with Agilent HC-C8(250 mm×4.6 mm,5 μm)column and the mobile phase consisted of acetonitrile-tetrahydrofuran-water(35∶ 1∶ 64).The flow rate was 1.0 mL/min,the column temperature was 30℃,and the UV detector was set at 278 nm.Results:The linear ranges of magnolin was 0.05~1.02 mg/mL(r=0.9998).The average recovery of magnolin was 97.9 %,and RSD2.0 %.Conclusion:The method is simple,repeatable and accurate,it can be applied in quantitative determination of evodiamine and rutaecarpine in Magnolia sprengeri Pamp.


The Bethe ansatz solutions of the massive Thirring model are renormalised and used to obtain exactly the ground-state properties of the sine-Gordon model with a finite density of topological solitons. Using a theory of 1D quantum fluids, the correlation function exponents and low-energy excitation spectrum are obtained. Expansions in various limits are given, and various crossovers described.


This paper proposes a conceptual model of information integrated management for hydropower EPC projects based on an study of information management in EPC pattern,presents the solutions on project targets integration,integrated control on investment and schedule based on RWBS,project organization integration,project management software integration and heterogeneous application systems integration,and develops a platform by using J2EE as an improved management tool of EPC contractors.


This paper describes the interaction force (adhesive force) based on the atomic force between clean metal (Cu, Ag or Au) surfaces in ultra high vacuum. The interaction force required to separate the contact between the tip and the flat plane is theoretically estimated by the atomic force based on the chemical bond and Hertz's contact theory. In a theoretical analysis, it is assumed that interaction force between clean surfaces can initiate plastic deformation even with zero applied load. This analysis also takes into account of the dislocation density and the size of shear stress field in the contact zone. The interaction force between the tip having radius of 5-25 μm and the flat plane was measured with an electorobalance in ultra high vacuum. At the same time, the contact area was measured by the electrical resistance of contact region. The results of measurement suggested that interaction force alone could initiate plastic deformation. The interfacial energy of Cu was 3.15 J/m2 given by the relation between the measured interaction force and the contact area. The value of measured interfacial energy agreed well with that of atomistically calculated 4.20 J/m2 by considering chemical bonds. Therefore, this suggested that the chemical bond (metallic bond) was induced at the interface.


CO emission has been detected in the irregular galaxy NGC 1569 using the 14 m telescope of the Five College Radio Astronomy Observatory. The central 1 kpc of this galaxy contains approximately 7 x 10/sup 6/ M/sub sun/ of H/sub 2/ and 1 x 10/sup 7/ M/sub sun/ of H I. Comparing NGC 1569 with the Scd galaxy IC 342, both of which are t roughly the same distance, the central regions have similar blue luminosities (approx.2 x 10/sup 9/ L/sub sun/), but NGC 1569 has a factor of 32 less CO. In order to form such a luminous region with a small supply of molecular gas, either the present burst of star formation in NGC 1569 must be very efficient and of short duration or the atomic hydrogen in the outer part of the galaxy must be resupplying the central region.


§ 1: Introduction. Seeing that Barbados has always been a station for our West-Indian ibrces, and that it has for some time been the first place of call for the Royal Mail steamers, it is somewhat strange that no adequate account of the geology of the island has ever been published, especially as it is one of the most healthy of our West-Indian possessions and offers few physical difficulties to the explorer. The earliest notice on Barbados is a short paper by Dr. J. Skey, but this gives very little information. Ehrenberg in 1s5g described the Microzoa obtained from the white earths of Barbados, and the Radiolaria have since become familiar to microscopical students; but the true geological position of these earths has never been made known. So far as we can learn, the only geological description of the island is that given by Sir Robert Schomburgk in his "History of Barbados" (1848). So far as it goes, and considering the date at which it was written, Sehomburgk's description is a good one. He describes the rocks under two heads : (1) Coral Limestone, (2) Siliceous rocks. His account of the Coral Limestone is fairly complete and accurate; he explains the phenomena which it presents by a gradual but discontinuous upheaval of the area, and truly remarks that the structure of the island offers several features which are difficult to reconcilewith Darwin's theory of coral-reefs. For the siliceous rocks he proposes the name of "Scotland Formation," because the area in


Cancer is a disease which dividing of abnormal cells cannot controlled and can invade nearby tissues. Cancer cells can also spread to other body organs. Moreover, we know that the genetic is a cause of cancer. So, we used SIR model (Susceptible-Infected-Recovered) for focusing on the mathematical model of cancer. We examined the dynamics of the disease and use dynamic analysis for analyzing the stability of the model. Then we found the equilibrium states and the basic reproductive number of the mathematical model of cancer. By the numerical simulations, the comparison of the parameters effect to the model, result, and conclusion are presented. CCS CONCEPTS • Applied computing; • Life and medical sciences; • Computational biology;


Abstract : A universally accessible web-based marine mammal call library using the recordings collected over the years by William Schevill and William Watkins creates an opportunity for scientific studies requiring dependable reference datasets of sounds produced by a species in a defined geographic region during specific seasons. The Woods Hole Oceanographic Institution Bioacoustics Lab, begun in the l950s under the direction of Schevill and Watkins, possesses approximately 2000 analog recordings of more than 90 species of marine animals. Metadata, organized and stored in stand-alone PCs, already exists for each of these recordings. In addition, these recordings are backed up by a reference library of more than 9000 selected marine animal papers (Watkins et al. 1990). This study presents an assessment of the contents of this marine mammal acoustic collection, recommendations for species-specific reference datasets, and potential architecture and costs for a web-based library.


We demonstrate high-fidelity electron spin read-out of a precision placed single donor in silicon via spin selective tunneling to either the D(+) or D(-) charge state of the donor. By performing read-out at the stable two electron D(0)↔D(-) charge transition we can increase the tunnel rates to a nearby single electron transistor charge sensor by nearly 2 orders of magnitude, allowing faster qubit read-out (1 ms) with minimum loss in read-out fidelity (98.4%) compared to read-out at the D(+)↔D(0) transition (99.6%). Furthermore, we show that read-out via the D(-) charge state can be used to rapidly initialize the electron spin qubit in its ground state with a fidelity of F(I)=99.8%.


The co-segmentation of a set of 3D shapes plays an important role in understanding and analyzing the 3D shapes. An unsupervised co-segmentation algorithm of 3D shapes based on components is proposed in view of the low efficiency and poor accuracy in the existing co-segmentation algorithms. Firstly, all the input models are pre-partitioned into meaningful components by calculating the conformal factor. Secondly, the 3D model is converted into a statistical model, and every column of the statistical model is used to represent different component unit, and then the corresponding relationship between different components is constructed and marked via Gaussian kernel function. Finally, dynamic k-means clustering algorithm is employed to realize meaningful co-segmentation. Experimental result demonstrates that the proposed algorithm can achieve co-segmentation of 3D model cluster with the same function but different postures and the obtained segmentation is convenient for further geometric analysis.


Objective To study the effect of nasojejunal and nasogastric feedings on incidence of ventilator-associated pneumonia(VAP) in patients with invasive ventilation.Methods Forty patients with invasive ventilation were randomly divided into two groups: nasojejunal feeding group and nasogastric feeding group.Occurrence of VAP was also observed during the period of feeding.Results The incidence of VAP in nasojejunal feeding group was 30%,in nasogastric feeding group was 75%,there was significant difference between the two groups(P0.01).Conclusion Nasojejunal feeding can reduce the incidence of VAP in patients with invasive ventilation


Submitted for the DPP15 Meeting of The American Physical Society Ion acoustic wave collapse via two-ion wave decay: 2D Vlasov simulation and theory1 THOMAS CHAPMAN, RICHARD BERGER, Lawrence Livermore National Laboratory, JEFFREY BANKS, Rensselaer Polytechnic Institute, STEPHAN BRUNNER, Ecole Polytechnique Federale de Lausanne — The decay of ion acoustic waves (IAWs) via two-ion wave decay may transfer energy from the electric field of the IAWs to the particles, resulting in a significant heating of resonant particles. This process has previously been shown in numerical simulations to decrease the plasma reflectivity due to stimulated Brillouin scattering. Two-ion wave decay is a fundamental property of ion acoustic waves that occurs over most if not all of the parameter space of relevance to inertial confinement fusion experiments, and can lead to a sudden collapse of IAWs. The treatment of all species kinetically, and in particular the electrons, is required to describe the decay process correctly. We present fully kinetic 2D+2V Vlasov simulations of IAWs undergoing decay to a highly nonlinear turbulent state using the code LOKI. The scaling of the decay rate with characteristic plasma parameters and wave amplitude is shown. A new theory describing two-ion wave decay in 2D, that incorporates key kinetic properties of the electrons, is presented and used to explain quantitatively for the first time the observed decay of IAWs. 1Work performed under auspices of U.S. DoE by LLNL, Contract DE-AC5207NA2734. Funded by LDRD 15-ERD-038 and supported by LLNL Grand Challenge allocation. Thomas Chapman Lawrence Livermore National Laboratory Date submitted: 22 Jul 2015 Electronic form version 1.4


Abstract : Anti-ship cruise missiles (ASCMs) are proliferating throughout the world, with some nations gaining the potential to launch them from submarines. The long range of these missiles implies that the submarine would rely on target detections from other forces. Communication delays and accuracy of locating data influence shot accuracy. This thesis uses a maneuvering target statistical tracker model (MTST) of target motion and indicates that the submarine can conduct an effective launch with accurate locating information even with long communications delays. The analysis shows that significant degradation of the probability of target intercept occurs for an alerted or evading target. The analysis then determines how this is affected by the presence of other potential targets for the missile. Two assumptions are made about the performance of the ASCM seeker. A simplistic seeker that selects a target at random performs very poorly if other naval escorts and random neutral shipping are encountered. A more intelligent seeker that uses information about the relative size of the ships and attacks the performance.


In this article, we propose a new signal-decomposition algorithm composed of three steps: principal components analysis to yield high-resolution range profiles with improved signal-to-noise ratio; estimation of whitening and mixing matrices using independent component analysis in distributed radar network; and signal decomposition to obtain inverse synthetic aperture radar (ISAR) images that correspond to rigid body and fast-rotating parts by using estimated two matrices regardless of complicated range migration. The proposed method efficiently removes image blur caused by micro-Doppler (MD) signals of rotating parts and reduces the sensitivity to noise. In simulations, our proposed method could perform accurate and robust removal of the MD signatures to obtain a focused ISAR image of an aircraft with fast-rotating parts.


An arrayed host:guest fluorescence sensor system can discriminate DNA G-quadruplex structures that differ only in the presence of single oxidation or methylation modification in the guanine base. These small modifications make subtle changes to G4 folding that are often not detectable by CD but induce differential fluorescence responses in the array. The sensing is functional in diluted serum and is capable of distinguishing individual modifications in DNA mixtures, providing a powerful method of detecting folding changes caused by DNA damage.


CO.RI.S.T.A. (Consortium for Research on Advanced Remote Sensing Systems)
is member of international science teams devoted to the studies of laser altimeters to fly on Europa Jupiter System Mission (EJSM) and Marco Polo Mission, currently under study of ESAs Cosmic Vision program as L-class and M-class mission respectively. Both the studies will focus on the assessment of alternative technical approaches that would reduce the mass, size and power requirements. In particular a Single Photon Counting (SPC) device will be studied taking into account the robustness against false detections due to harsh radiation environment in the Jupiter system. Innovative technical aspects which will characterize the studies of laser altimeters in the scenarios of EJSM and MarcoPolo, which will permit us to make major contributions to the science goals of the two missions.


AbstractMicropollutants (MPs) can be defined as inorganic and organic substances present at low concentrations (pg/L–ng/L) in the environment, however, having adverse consequences for living organisms even at these low concentrations. To date, an effective and sustainable global strategy against this insidious contamination of aquatic environments barely exists. Source controls and technical systems, such as wastewater treatment plants, function only as partial barriers or not at all. The enzyme laccase was identified as active in the degradation of different MPs. We present data showing that laccase from Cerrena unicolor immobilized on mesoporous silica beads controlled porosity carrier (CPC) in a continuous column reactor was suitable for elimination of MPs including bisphenol A(BPA), 4-nonylphenol (NP), and triclosan (TCS). A system equipped with a 3.5 × 0.7 cm column packed with immobilized laccase CPC beads (43 units/g of enzyme activity), and eluted at 1 mL/min with a solution containing BPA, NP, an...


Lung cancer is a global health problem with non-small cell lung cancer (NSCLC) being the most common histopathological variant causing almost 28% deaths in the United States of America. Platinum compounds were the mainstay of treatment, and since past 10 years, various newer targeted therapies have come into play. Epidermal growth factor receptor and anaplastic lymphoma kinase mutations play a major role in the development of advanced disease. Hence, targeted therapies and immunotherapies will remain an integral part in the management of advanced disease. Hence, this review focuses on the newer drugs approved by Food and Drug Administration to treat NSCLC


The human population worldwide has showed during the past years an alarming increase in the incidence of obesity in all races, sexes, social, cultural, religious or geographic environments. Romanian population has adopted generally the Western countries' lifestyle and presently is one of the leader countries in the high incidence in obesity, especially in childhood obesity. This study is a first approach of genotyping in a selected Romanian cohort comprising adults and children for two genes related both to energy accumulation and expenditure, respectively: FTO rs9939609 and ADRB3 rs4994. The results showed that although statistically significant in both groups, the FTO allele A was more associated with obesity in adults than in children. The FTO rs9939609 polymorphism is a common SNP in our Romanian study group, its mutant A allele showing a higher frequency than the worldwide rates. The selected ADRB3 polymorphism is a rare genetic variant in our Romanian cohort: its C allele has shown correlations, although not statistical, with obesity susceptibility, all of the heterozygous (TC) individuals belonging to obese groups, while no homozygous mutant (CC) subjects were reported. Although rare, the ADRB3 mutant frequency was higher in our Romanian groups than in the reported worldwide population. In contrast with the FTO genotype, the ADRB3 genotyping showed a higher association with the predisposition for obesity in children than in adults in our cohort.


For pt.I see ibid. vol.19 p.411 (1985). A graph theoretic analysis is made of the m-spin correlation functions of the lambda -state Potts model. In paper I, the correlation functions for m=2 were expressed in terms of rooted mod- lambda flow polynomials. The authors introduce a more general type of polynomial, the partitioned m-rooted flow polynomial, which plays a fundamental role in the calculation of the multispin correlation functions. The m-rooted equivalent transmissivities of Tsallis and Levy (1981) are interpreted in terms of percolation theory and are expressed as linear combinations of the above correlation functions.


The objective of this study was to estimate genetic parameters for body weight at 60 (P60), 90 (P90), and 120 (P120) days of age in escargots of the subspecies Cornu aspersum maximum, evaluating the influence of fixed and covariable effects on these traits. The data used were collected from escargots kept in a total confinement system. The significant fixed effects and covariates for these traits were tested in a general linear model by the F-test, considering a level of significance of 5%. Both the fixed effects of box and birth year and the quadratic effect of age of weighing as a covariate were significant (p < 0.05) for P60, P90, and P120. The Restricted Maximum Likelihood (REML) methodology was used to estimate (co)variance components and genetic parameters. High heritability for P60, P90, and P120 (0.38, 0.55 and 0.78, respectively) and high genetic correlations (0.58 to 0.77) among the traits were observed. The genetic parameters can be used as a basis for studies and practical applications to increase zootechnical indexes in this population.


mRNA translates the DNA information to the synthesizing proteins, and the resulting glycoproteins in the endoplasmic reticulun are translocated to the Golgi apparatus, where oligosaccharides are modified to have diverse structures. A whole process called "post-translational modifications (PTMs)", provides glycoproteins with diverse structures and functions. The functions of the proteins are also precisely regulated afterwards through the "processing" of the glycan chains by glycosidases or transferases in response to the various biological environments. Can chemists mimic the glycan-PTMs by use of the synthetic organic chemistry, and can these PTM mimicries be applied to in vivo imaging or targeting? This report describes (1) chemistry-based site-selective modification of proteins by oligosaccharides (chemical post-translational mimicry) and (2) new strategy for tumor targeting by artificial cells, based on the chemical engineering of the cell-surfaces by oligosaccharides. Davis and co-workers recently succeeded in mimicking the glycan-PTMs of proteins by the chemical methods, and targeting the mouse and rat brain inflammation and disease in vivo [Nature (2007) 446, 1105-1109]. They genetically engineered a target protein in the E-coli system by exchanging the methionine to artificial amino acids containing the azide and/or the acetylene moieties, and subsequently, the Cu(I)mediated Huisgen cycloaddition reaction (Sharpless/Meldal click reaction) was performed to introduce the glycans and/or other small functional molecules on the specific sites of the protein. Although the Cu(I)-mediated Huisgen cycloaddition requires a few mg of the protein, more than 1000-times equivalents of CuBr with high purity (99.999 %), and excess amount of the quaternary amine as an activator, the mono~ tetra-saccaharides can be efficiently introduced on the protein. The different functional groups, such as the glycans or the other small organic molecules, could be introduced at two different sites on the same protein, by making use of the disulfide bond formation with cystein residue. Based on their chemistry-based PTM mimicry, in vivo experiments for targeting the P-selectin were performed. By using SSβG with LacZ-type galactosidase activity as a protein template, the sialyl Lewis X and the acidic p-toluenesulfonyl group were doubly introduced to the specific sites of the protein, 化学的に糖鎖修飾を施した人工糖タンパク質や人工細胞によるインビボイメージング


Introduction In sports psychology, the issue of finding resources to overcome stress remains relevant at present. Currently, the priority is the search for personal resources that can help overcome difficult life situations. Currently, the priority is the search for personal resources that can help overcome difficult life situations. Research by many psychologists (Folkman S., Hobfoll S., Haan N.A., Heim E., Lazarus R., Moos R.N., Schaefer C., Grin O.R., Dementiy L.I., Kalnysh V.V., Tukaiev S.V., Khazova S.A. et al) is devoted to this topic. Among the coping resources, the authors single out motivation, locus of control, resilience, self-control, purposefulness, outlook, intelligence, etc. Objectives The purpose of the study is the analysis of literary sources regarding the study of the locus of control as a personal coping resource of an athlete. Methods To realize the goal of the work, the following were used: theoretical analysis and generalization of literary sources and Internet data. Results According to the results of research by domestic scientists, the locus of control and responsibility can act as a coping resource. It was found that the internal locus of control is associated with a low level of anxiety, and the external one with a high one; in addition, an inverse relationship between the locus of control and the level of neuroticism was found (Dementiy, 2005). This indicates that respondents with an internal locus of control are more stable in their behavior in situations that provoke anxiety and actualize personal anxiety. Internality allows a person to maintain a sense of control over the situation and his condition. It has been proven that the relationship between the locus of control and the state of anxiety depends on volitional self-control. However, along with this, the phenomenon of "heaviness of responsibility" is known in the scientific literature, which manifests itself in a sharp increase in anxiety with an internal locus of control. This may indicate that internality "loses" its resourcefulness under certain conditions: relationships between internality and anxiety are evident only at a low level of self-control. In the case when a person has developed self-control, such a connection is broken. Conclusions The generally accepted structure of personal resources, which determine the effective behavior of an individual under conditions of stress, has not yet been formed. Locus of control can act as a coping resource in the structure of self-regulation of an individual. Disclosure of Interest None Declared


Using Swedish data, this study investigates whether financial statement information can be used to predict changes in the medium-term book return on owners' equity and subsequently evaluates the performance of trading strategies based on such predictions. A univariate prediction model based on the past book return has higher prediction accuracy than more elaborate models that include additional accounting numbers. The main trading strategy generates a hedge position return of 29% over a three-year holding period. Interestingly, most of the return is attributable to the long position. However, the results are found to be sensitive to the choice of return metric. Copyright (c) 2008 The Author Journal compilation (c) 2008 Blackwell Publishing Ltd.


Since the demonstration by Stork and Ficini in 1961 that unsaturated diazoketones undergo intramolecular cyclization to form cyclopropanes the intramolecular reactions of α-diazocarbonyl compounds have been extensively studied under thermal, catalytic, and photochemical conditions. Intramolecular cyclization of α-carbonyl carbenes and carbenoids has found widespread application to the synthesis of theoretically interesting compounds such as bullvalene, twistane, bridged annulenes, and barbaralone, as well as syntheses of natural products such as sabinene, sirenin, α-chamigrene, and phyllocladene. The reaction has also allowed the construction of several intriguing polycyclic systems that were unattainable by alternative methods.

A recent review has covered the reactions of diazoacetic esters with alkenes, alkynes, heterocyclics, and aromatic compounds. Unsaturated alkoxycarbonyl carbenes (:CHCO2R) and unsaturated carbonyl carbenes (:CHCOR) (where R contains either aromatic or olefinic groups), which are considered to be intermediates in the absence of catalyst, have been the subject of several other reviews. A review concerning photochemically, thermally, and catalytically induced Wolff rearrangements of α-diazocarbonyl compounds has recently appeared. However to date no comprehensive review has appeared which demonstrates the synthetic potential of α-diazocarbonyl insertion and addition reactions.

In reviewing the reactions of α-diazocarbonyl compounds chosen not to include certain peripheral topics such as intermolecular reactions, intramolecular dimerization of bis(α-carbonyl carbenoids) to give diacyl cycloolefins and intramolecular trimerizations of tris(α-keto carbenoids), affording triacylcyclopropanes are not included. Also excluded are base-catalyzed reactions of α-diazocarbonyl compounds and certain ring-contraction reactions involving CC bond insertion of intermediate α-ketocarbenes.

The topics included in this report are the intramolecular reactions of α-carbonyl carbenes and carbenoids with olefinic and aromatic unsaturation, with CH bonds, and with CC and NH single bonds. Also included are acid-catalyzed cyclization reactions of α-diazoketones.

Keywords:

diazocarbonyl compounds;
intramolecular reactions;
scope;
limitations;
diazoketone addition;
diazoester addition;
diazocarbonyl insertions;
acid catalyst;
diazoketone cyclization;
experimental procedures;
olefins;
CH bonds;
cyclization;
intramolecular addition


THE USE OF POULTRY WASTE AS A DIETARY SUPPLEMENT FOR RUMINANTS. The use of poultry waste as a dietary supplement in ruminant ration could have a considerable effect on reducing costs, insufficiency of protein in diet, and on solving disposal problems. The chemical composition of poultry waste and its safe use in ruminant nutrition were investigated prior to its use as a dietary supplement. No appreciable differences in chemical composition were noted in poultry wastes between oven and sun dried forms. The high content of protein, energy, and minerals in poultry waste indicated its importance as a partial substitute for concentrates in the diet. The numbers of total bacteria and pathogenic microorganisms such as Salmonella and E. coli detected in poultry waste were within the acceptable limits. Farm testing of rations containing poultry wastes were carried out on sheep (ewes and lambs), Friesian cattle and buffalo heifers. In ewes fed during late pregnancy and lactation, milk yield and performance did not show any significant changes. Lambs suckled from ewes fed on poultry waste did not show any significant difference in weaning weight, average daily weight gain or feed efficiency (kg feed used/kg weaned weight). However, the poultry waste group had shorter age at weaning than the control group. In another feeding trial on growing lambs after weaning, mean daily body weight gain was higher in lambs fed on a ration containing poultry waste than the control ration. In Friesian and buffalo calves, no significant differences in average daily body weight gain were found as a result of inclusion of poultry waste in the ration. In buffalo heifers various estimated reproductive parameters indicated no appreciable differences due to the inclusion of poultry waste in the diet except that the number of ovulations and number of services/conception were both higher in the group fed with poultry waste.


In National Security Cinema: The Shocking New Evidence of Government Control in Hollywood (2017), Dr. Matthew Alford and Tom Secker offer convincing proof that the US Department of Defense, CIA and FBI have for decades used various means to manipulate content and even deny production of certain Hollywood projects, often using "national security" as a pretext to censor film and television. The real aim of these operations, according to the authors, is to advance "violent, American-centric solutions to international problems based on twisted readings of history." Alford is a Teaching Fellow at the University of Bath in England. He is also the author of Reel Power: Hollywood Cinema and American Supremacy (2010). Secker is a private researcher who runs spyculture.com—an online archive about government involvement in the entertainment industry. Their book argues that the US military has had an influential relationship with Hollywood products since its earliest days. Alford and Secker point out that the Home Guard (reserve forces outside the National Guard) provided tanks for "the infamous feature film [D.W. Griffith's] Birth of a Nation (1915), in which black slaves revolt against their masters, before the Ku Klux Klan ride in on horseback to save the day." Using the Freedom of Information Act, the authors gained access to files that exposed the extent of government censorship in films between 1911 and 2017. The DOD (Department of Defense, or Pentagon) provided military equipment and "advice," and even allowed members of the military to make appearances, in exchange for some degree of control over the content of 814 films. The authors continue, "If we include the 1,133 TV titles in our count, the number of screen entertainment products supported by the DOD leaps to 1,947. If we are to include the individual episodes for each title on long-running shows like 24, Homeland, and NCIS, as well as the influence of other major organisations like the FBI, CIA and White House then it becomes clear that the national security state has supported thousands of products." Alford and Secker offer the Transformer movie franchise (2007-2018 so far, most of it directed by Michael Bay) as an example of how the DOD reinforces its "national security" interests by using different "under the table" methods of influencing the making of what was (and still is) considered to be pure entertainment. Normally, filmmakers have to send drafts of the script to the DOD along with their request for material support. Not so with the makers of Transformers. The DOD paid the filmmakers to gain "very early influence over the scripts" by giving them the most military assistance in filmmaking history, e.g., "twelve types of Air Force aircraft and troops from four different bases." The second Transformers film was provided with $150m F-22 fighters. The authors rightly conclude that the Transformers franchise is anything but "apolitical," and is, in fact, an example of what's come to be known as "war pornography." The unstated but intentional message to the audience is to "trust in officialdom" to "bring 'em home" from foreign wars and invasions, no matter the number of human beings, American or otherwise, soldier or civilian, who are killed in the process. When the authors turn to investigating the CIA's influences on movies, they work from available facts and information in regard to three different eras: 1943-1965, 1966-1986 and 1986 to the present. While the CIA has censored or interfered with far fewer movies, its repressive methods and means, fittingly, are even more insidious. During the immediate postwar period, officials of the newly formed CIA worked, according to Alford and Secker, "to ensure that Hollywood films did not depict them in any form." Meanwhile, the agency, from its establishment, was busy "recruiting assets within the highest levels of the film industry and using them to spy on Hollywood and to add and remove material from movie scripts." The film versions of George Orwell's Animal Farm (1954, John Halas and Joy Batchelor) and Nineteen Eighty-Four (1956, Michael Anderson) exemplify the kind of movies that the CIA would be expected to censor. Indeed, film scholars, our authors point out, have long been aware that both adaptations "were directly affected by the CIA." In the case of Animal Farm, the changes to the film's ending were designed to encourage revolts against "communist dictatorships," i.e., the various Stalinist regimes in the USSR and Eastern Europe, "ironically just as, in the real world," Alford and Secker point out, "the CIA was overthrowing the democratically elected governments in Iran and Guatemala and launching operations against Sukarno's independence government in Indonesia." The CIA discovered the effectiveness of working through agents—or Hollywood figures who would act as agents—during the Cold War period. As an example, the authors reveal that Luigi Luraschi, the head of censorship at Paramount Studios, regularly contacted "an anonymous individual" at the CIA to inform him of Paramount's ability and willingness to alter films to conform to US government interests. Among the many Paramount movies from which scenes were added or deleted—intended to improve the image of American society—include the apparently innocuous Sangaree (Edward Ludwig), The Caddy (Norman Taurog) and Houdini (George Marshall), all released in 1953, and


We consider a scenario where agents have to exchange data in a wireless ad-hoc network, although it is not connected. We assume that each agent has a static home base. To improve connectivity, each agent is allowed to move away from his home base, but only for a limited distance which may be different for different agents. These distances might be dictated by limited batteries of the agents, which forces them to return to their home charging station after a while. An application currently widely considered in literature (and in projects and applications) is disaster management, where helpers are equipped with smartphones to submit important local information to a coordinating station. In case of the network being disconnected, mobile "postmen'' are used for long distance connections. In this paper, we focus on the aspect of "communication by postmen''. We model such a scenario by a weighted directed graph. It consists of n (static) nodes describing the home bases of the agents. A directed edge from base $v_i$ to base $v_j$ with weight $w(v_i,v_j)$ indicates that agent $a_i$ can walk from his home base to the home base of $a_j$, which needs time $w(v_i,v_j)$. If agent $a_j$ is at home when agent $a_i$ arrives, they can exchange messages. % Alongside with the introduction of the model, we present a randomized distributed algorithm for all-to-all message dissemination and show that its performance is, in many cases, close to optimal.


ECMLR is a sincryption scheme with message recovery and message linkage recovery based on the elliptic curve crypto system.The message's block is constructed in recursive mode,taking the present parameter as the input of the next parameter.By doing this,the whole message can be recovered recursively one by one. And the communicate traffic is reduced significantly.But in the research,it is found that this scheme's security is based on the different message key.So an improvement is given with proof.


The EU Water Framework Directive (WFD) obliges EU Member States to achieve good ecological status in all surface waters by 2027 at the latest. In many regions, this implies fundamental transformation from engineered water landscapes back to near-natural structures. By example of the German State of Lower Saxony it is shown how this transformation of water landscapes essentially requires a transformation of the institutional foundations of water management, too. It is argued from a legal perspective that certain general, justiciable minimum requirements are to be deduced from the WFD as to (1) planning and enforcement of restoration measures, (2) land acquisition, (3) organisation and (4) finance which delimit the ample margins Member States enjoy in designing the institutional substructure. With regard to Lower Saxony, it is explained why this State is clearly failing to meet the minimum requirements and how it needs to transform its institutional arrangements to make them fit for purpose. The article concludes that WFD enforcement should pay more attention to the institutional underpinning and it submits that examples and benchmarks should be further explored by comparative research.


Preface Childhood and Youth Seven Years' Hard: Kipling in India The Conquest of London Citizens of America The Song of the English Kim In a Hidden Kingdom Towards Armageddon The Great War and After The Last Decade Bibliography Index


We show the existence of solitary wave solutions of finite energy for a model to describe the propagation of internal waves for wave speed $c$ large enough. Furthermore, some of these solutions are approximated using a Newton-type iteration combined with a collocation-spectral strategy for spatial discretization of the corresponding solitary wave equations.


Irritable bowel syndrome is invariably a mystery to modern medicine. Gastrointestinal symptoms occurring in IBS significantly reduce the well-being and quality of life of patients. It is estimated that many factors take part in the aetiology of disease development, including visceral hypersensitivity, disorders along the brain-intestinal axis, or chronic stress. It has been proven that a combination of pharmacotherapy, individual dietary recommendations, and often also psychotherapy can contribute to the reduction of persistent symptoms of irritable bowel syndrome. In recent years, the low FODMAP diet in patients suffering from IBS has caught the attention of the medical community. Many clinical studies and extensive meta-analyses indicate the effectiveness of the above diet in reducing abdominal pain and flatulence in patients, due to the limitation or exclusion from the diet of products rich in easily fermentable carbohydrates. These carbohydrates are less well absorbed in the human intestine, which is why they contribute to excessive gas production and the formation of flatulence. Mention is also made of the effect of the low-FODMAP diet on the change of intestinal microbiota (especially in terms pod stałą opieką dietetyka. Słowa zespół jelita drażliwego, low FODMAP, mikrobiota jelit of genre Bifidobacterium having a beneficial effect on bowel function) in people with irritable bowel syndrome. However, it should be remembered that the implementation of this diet is a big challenge for patients, which is why they should be under the constant care of a dietitian.


There is worldwide concern regarding the development of biodegradable polymer as a remedy towards harmful effects caused by synthetic polymer. These materials which are synthesised by petrochemical process, contribute towards air pollution and waste management problem. Biodegradable polymers are able to significantly reduce the environment impact in terms of energy consumption and greenhouse effect. Biopolymers are synthesised by microbial sources and this study aims to produce biopolymer from Pseudomonas fluorescens (pf01) by fermentation process. Biopolymers produced by bacterial species were screened by Sudan Black B staining method. The polymer extraction was carried out by Sodium Hypochlorite method. The maximum biopolymer production of 55% was observed at 72 hrs. FTIR and DSC methods were carried out for the characterisation process.


Polymer blends of carboxylated butadiene-acrylonitrile copolymer (nitrile rubber) and polyamide 6 (PA6) were developed in twin screw extrusion. The rubber was cured with SP 1045 methylol phenolic resin during melt mixing in twin screw. Effect of degree of carboxylation in the rubber phase on blend properties has been assessed. Phase morphologies have been characterized using transmission electron microscopy. A compatibilizing NBR-g-Nylon 6 graft copolymer generated in situ during melt mixing via interfacial reaction between the COOH groups in NBR and the NH2 end groups in nylon 6 has been effective in generating a fine and stable dispersion of the rubber within the polyamide matrix. The graft copolymer has been characterized by DMTA. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 104: 372–377, 2007


Serious hemorrhage is a constant threat to patients receiving coumarin anticoagulants. While life-threatening bleeding is not common, the physician should be aware of the possibility of such a complication and take every possible precautionary measure. Moreover, these drugs should not be used unless the benefit to be obtained outweighs the possible threat to life. The coumarin derivatives alter the concentration of the coagulation factors in the plasma by interfering with their synthesis by the liver. At one time it was thought that the chief effect was on prothrombin concentration but it is now known that the concentration of factors VII, IX, and X are also reduced. The one-stage prothrombin time is still widely used in this country as a measure of the effect of these drugs on coagulation although it is not specific for a single coagulation factor. Specific tests for the various factors have not been sufficiently useful to


Funding was provided by the Minerals Management Service under contract Number 14-12-0001-30262;
Sea Grant under contract Number NA86AA-D-FG090; and the Office of Naval Research
Young Investigator Program under contract
Number N00014-86-K-0579.


This article, through comparative historical analysis, examines the traditional marriage rituals of the Dungan diaspora in Kazakhstan. Dungans are Chinese-speaking Muslims who were forced to migrate to present-day Kazakhstan, Kyrgyzstan, and Uzbekistan after the defeat of their revolt against the Qing dynasty from 1877 to 1888. The article focuses on the diversity of wedding ceremonies in three zones where Dungan settled in Kazakhstan: Zhalpak Tobe and Sortobe, two rural areas in the Zhambyl region; and Zaria Vostok, near the city of Almaty. I find that the local variations in traditional wedding ceremonies stem from their close intercultural and social cooperation with non-Dungan peoples—primarily Kazakhs, Uzbeks, Uyghurs, and Russians. The example of wedding rituals shows that, while Dungan existence in another cultural environment has stimulated the consolidation of their ethnic group, preserving many of the traditional archaic cultural features, it has also led to the transformation of the marriage ceremonies. I address a much-neglected pathway—the nature of borrowed elements in Dungan wedding rituals—and ask why the extent of borrowing varies from community to community even though the Dungan arrived from China with similar traditions.


The next project is the result of research carried out by members of the research nursery AXONES Faculty of Industrial Engineering during the period since the first half of 2009 to the first half of 2010 in the neighborhood of Engativa applied to the manufacturing sector clothing.
6
The first phase consisted of calculating the sample of enterprises which would apply to the pilot and corrected survey, pilot test was performed and corrections based on the application of the test. The result of this phase was a survey corrected.
The second phase was the diagnosis based on the implementation of the survey which was able to collect the information necessary for the development of the methodology through the process of tabulation and analysis.
In the third phase variables were identified that would be the basis for the approach of the methodology and the development of guidelines for the improvement of each variable with which it seeks to obtain microentrepreneurs tools to develop their products and gain competitive advantage in their market.


Article 50, introduced into the Treaty on European Union by the Treaty of Lisbon, sets out a mechanism for a state which wishes to end its membership of a supposedly 'ever closer Union'. Article 50 provides"1. Any Member State may decide to withdraw from the Union in accordance with its own constitutional requirements.2. A Member State which decides to withdraw shall notify the European Council of its intention. In the light of the guidelines provided by the European Council, the Union shall negotiate and conclude an agreement with that State, setting out the arrangements for its withdrawal, taking account of the framework for its future relationship with the Union. That agreement shall be negotiated in accordance with Article 218(3) of the Treaty on the Functioning of the European Union. It shall be concluded on behalf of the Union by the Council, acting by a qualified majority, after obtaining the consent of the European Parliament.3. The Treaties shall cease to apply to the State in question from the date of entry into force of the withdrawal agreement or, failing that, two years after the notification referred to in paragraph 2, unless the European Council, in agreement with the Member State concerned, unanimously decides to extend this period.4. For the purposes of paragraphs 2 and 3, the member of the European Council or of the Council representing the withdrawing Member State shall not participate in the discussions of the European Council or Council or in decisions concerning it.A qualified majority shall be defined in accordance with Article 238(3)(b) of the Treaty on the Functioning of the European Union. 5. If a State which has withdrawn from the Union asks to rejoin, its request shall be subject to the procedure referred to in Article 49." The purpose of this contribution is to make some brief observations about the role of this article in any process of Brexit which may take place in the wake of a vote to leave the European Union on 23 June next.


Aomori is located in the most northern pref. of main land in Japan. And it is uniquely situated within the amalgam of local instruments Tsugaru and Nambu's traditional local arts. Referring to [1, 2], the city's traditional music preservation society and schools have eagerly wished a technics to precisely score local music, especially traditional Tsugaru Shamisen.This music will be preserved as Western & Shamisen scores, which avoid relying individually on the oral education of this kind of traditional local music for trainees. In this research, "Electronic Shamisen" has been invented with pick-up microphones attached with strings and automated scoring equipment, which automatically records scores from the sound resources by cooperative agent method. Relevant researches are shown in [1–4].


Recent advances in doping analysis (24): Proceedings of the Manfred Donike Workshop; 34th Cologne Workshop on Dope Analysis; 21st to 26th February 2016 page 88-91


To solve the problem of lacking of spare well slots on offshore platform,the adding well slots technology is researched and developed.By analyzing and demonstrating the space condition,the drilling type,structure strength and system capabilities of the old platform,the applicability of the adding well slots was confirmed.The design of the adding well slots was refined and improved,and then it was carried out in the engineering practice.It was demonstrated that the adding well slots can meet the needs of drilling adjust well of old platform with the specialty of simple structure,short project period,low-cost and great economic benefits.


Abstract - We all be familiar with two well-known forms of Carbon which are diamond and graphite. Diamond is a one of the toughest and hard material in the earth. Graphite is well-known as most brittle material. But one thing had changed forever, when two physicists A.K.Geim and K.S. Novoselov had got noble prize for "Graphene". On the basis of his research work published title" The rise of Graphene". His work shows that Graphene is 200 times stronger than cast iron. It have so many desirable qualities to use in our daily life. Graphene, becoming eminent as a true 2-D material, had got ever-increasing attention due to its unmatched physicochemical properties (excellent conductivity, high surface area, high mechanical strength ,ease of functionalization and mass production). Graphene is a extraordinarily amazing material with countless highest extents to its name. It is the thinnest material in the universe and the strongest yet calculated. Its charge carriers exhibit massive inherent mobility, have the negligible effective mass (it is zero) and can travel micrometer-long distances without scattering at room temperature. Graphene be able to uphold current densities 6 orders higher than copper, shows record thermal conductivity and stiffness, is impermeable to gases and reconciles such contradictory qualities as brittleness and ductility. Electron transport in graphene is described by a Dirac-like equation.


The European Union (EU), during last two years, has experienced two significant events: the reform of the Common Agricultural Policy (CAP), known as the "Mid-Term Review", and the enlargement of the European Union to 10 new members. This work aims at evaluating some economic changes due to these events. One issue regards the main domestic effects produced within the "new" EU composed of 25 members (EU25) with respect to the "old" EU (EU15). The other issue of this work consists of understanding the level of market access, in terms of effective protection, by a new theoretical consistent index (Anderson, 1998), doing a comparison between the "old" EU15 and the "new" EU25, in terms of effective protection. The methodology chosen in this work is a CGE model and, in particular, the Global Trade Analysis Project (GTAP) model.


This paper studies the H-infinity filtering method for sensor networked spacecraft thermal experiments. By constructing Lyapunov function, sufficient conditions are derived for the desired filtering gains with the help of matrix transformations. In the end, an illustrative example of surplus temperature filtering during spacecraft thermal tests is presented for verifying the applicability of our proposed method.


RECENTLY methods have been described for the scparation of brain nuclei, which according to morphological criteria have been referred to as large or neuron-cnriched and small or glia-enriched nuclei (AUSTOKER e t a/., 1972; GUIDITTA et a/., 1972; KATO & KUROKAWA, 1967; LOVTRUP-REIN, 1970). However, the present knowledge of biochcmical differences between thc two nuclear classes is fragmentary. Neuronal nuclei havc bcen reported to display a more active endogeneous RNA polymcrasc A and B reaction and a much higher in viuo labclling of RNA than the glial nuclei (ALBRECHT. in press; MIZOBE ct af., 1974). This higher tcmplatc activity of neuronal chromatin has been suggested by MIZOBE et a/. (1974) to be due to its weaker steric restriction and to an unusual wealth of euchromatin. The present experimental evidence suggests that transcription is controlled by two major protein components associated with DNA : basic (histone) and acidic (nonhistone) protcins, thc former being predominantly involved in thc nonspccific repression and the lattcr in the organ specific restriction of the DNA template (for references,


The Schiff base, 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L1) has been synthesized by the condensation reaction between 2-aminopyrimidine and 2-benzoylpyridine and characterized using 13C-NMR, 1H-NMR, microanalysis, FT-IR, DEPT-135, HSQC, HMBC, COZY, NOESY. The reaction of 1-phenyl-1-(pyridin-2-yl)-N-(pyrimidin-2-yl)methanimine dihydrate (L1) with salts of V(IV), Co(II) and Cu(II), however, resulted in the hydrolysis of L1 to give binuclear metal complexes of 2-benzoylpyridine (L2) and phenyl(pyridin-2-yl)methanediol (L3) which were characterized using UV-visible spectroscopy, and TGA. The single crystal x-ray structure determined for the Copper(II) complex revealed that we obtained a compound previously obtained using a different method of synthesis. The Schiff base ligand (L1) is soluble in methanol, ethanol, DMSO, acetone and DMF. Microanalysis and Spectroscopic studies indicated that binuclear metal complexes were obtained by the coordination of metal ion to 2-benzoylpyridine (L2) and phenyl(pyridin-2-yl)methanediol (L3) from the hydrolysis of L1. Spectroscopic and elemental analysis reveal the formation of square pyramidal complexes of Co(II) and Cu(II) and a square planar complex of V(IV). In vitro antibacterial and antifungal activity against three bacterial strains (Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus) and three fungal stains (Candida albicans, Candida glabrata and Candida parapsilosis) showed moderate biological activity. Antioxidant studies reveal that only the binuclear Co(II) and oxovanadium(II) complexes are potent to eliminate free radicals.


This paper presents the equivalent series resistance (ESR) modeling method of filter components and its stability impact of LCL filtered grid-connected voltage-source converters (VSCs). First, the time-domain models of filter inductor and capacitor are developed for modeling the ESR effect, which are used in simulations. Then, the current control loop gains of the grid-connected three-phase VSC, which include the ideal LCL filter and the ESR-modeled LCL filter are compared. The result shows that the ESR affects both the resonance peak and the phase characteristic in the frequency domain. Finally, in order to verify accuracy of proposed model, the loop gain is measured by network analyzer in the experimental set up, which shows that the analytical loop gain with proposed ESR modeled inductor agrees very well with experimental value. This verification means that the ESR modeling method is useful for an accurate stability analysis.


SCOPE
This study aims to investigate and compare the potentially neuroprotective effects and underlying mechanisms for brown seaweed polysaccharides (PS) of Alginate (Alg) and its two components, including Polymannuronic acid (PM) and Polyguluronic acid (PG), against Parkinson's disease (PD) pathogenesis.

METHODS AND RESULTS
Model mice of PD were pretreated with Alg or PM or PG, separately via oral gavage once per day for four weeks. Our results found PM improved motor functions of PD mice, but Alg or PG did not. PM or PG, but not Alg, could prevent dopaminergic neuronal loss by increasing tyrosine hydroxylase expressions in midbrain of PD mice. The neuroprotective effects of PM relied on its anti-inflammation effects and its ability to improve striatal neurotransmitters (serotonin and 5-hydroxyindole acetic acid) levels in PD mice. PM inhibited inflammation, but PG or Alg induced inflammation in systemic circulation of PD mice. The neuroprotection provided by PG might be related to its ability to increase striatal neurotransmitter of 5-hydroxyindole acetic acid levels in PD mice.

CONCLUSION
PM played better than PG to provide neuroprotection, but Alg did not show any neuroprotection against PD. Alg and its two components acted differently in preventing dopaminergic neuronal loss in PD mice. This article is protected by copyright. All rights reserved.