ABSTRACT. Henneguya rondoni n. sp. found in the peripheral lateral nerves located below the two lateral lines of the fish Gymnorhamphichthys rondoni (Teleostei, Rhamphichthyidae) from the Amazon river is described using light and electron microscopy. Spherical to ellipsoid cysts measuring up to 110 μm in length contained only immature and mature spores located in close contact with the myelin sheaths of the nervous fibres. Ellipsoidal spores measured 17.7 (16.9–18.1)‐μm long, 3.6 (3.0–3.9)‐μm wide, and 2.5 (2.2–2.8)‐μm (n=25) thick. The spore body measuring 7.0 (6.8–7.3)‐μm long was formed by two equal symmetric valves, each with an equal tapering tail 10.7 (10.3–11.0) μm in length. The tails were composed of an internal dense material surrounded by an external homogeneous sheath of hyaline substance. The valves surrounded two equal pyriform polar capsules measuring 2.5 (2.2–2.8)‐μm long and 0.85 (0.79–0.88)‐μm (n=25) wide and a binucleated sporoplasm cell containing globular sporoplasmosomes 0.38 (0.33–0.42) μm (n=25) in diam. with an internal eccentric dense structure with half‐crescent section. Each polar capsule contains an anisofilar polar filament with 6–7 turns obliquely to the long axis. The matrix of the polar capsule was dense and the wall filled with a hyaline substance. The spores differed from those of previously described species. Based on the ultrastructural morphology of the spore and specificity to the host species, we propose a new species name H. rondoni n. sp.


The regular transmittance of light or similar radiation through a flowing suspension of particles fluctuates because of the random occurrence of particles in the beam.In the work presented here, a ...


Selection of refugia plants is an important step when engineering the agroecological system. The refugia plants can be repellent or attractant to insect pests and in many species the role of each plant can be studied using the olfactory responses of the insect to volatile chemical cues emitted by the plant. The objective of this study was to determine the olfactory response of Plutella xylostella (Lepidoptera: Yponomeutidae) adults to several refugia plant candidates. Y-tube olfactometer tests were used to determine responses of P. xylostella to candidate plant species including: Ageratum conyzoides, Galinsoga parviflora, Synedrella nodiflora, Sphagneticola trilobata, Brassica rapa, Rorippa indica, Arachis pintoi, Ocimum basilicum, Apium graveolens, and Portulaca oleracea. Olfactory choice tests were conducted to compare preferences of insect. The results showed that R. indica, G. parviflora, and S. trilobata flowers attracted P. xylostella. R. indica and B. rapa leaves had high attractiveness for P. xylostella adults. At the same time, the A. graveolens, A. conyzoides, and O. basilicum leaves showed potential repellency. The conclusions of this study are R. indica and B. rapa have potential for use as trap crops, while A. graveolens, O. basilicum, and A. conyzoides have potential as repellent plants. Further study is necessary to test the olfactory response of P. xylostella's natural enemies to these refugia plants.


I will present our integrated, imaging-based technology framework for reconstructing development and function of the early nervous system in vivo, which combines high-speed multi-view light-sheet microscopy with automated approaches to large-scale image analysis.


EQRELOC includes earthquake hypocenters, their locations relocated by the VELEST model (Kissling and others, 1995), and the connecting vector for each pair of old and new locations. The starting data set consists of earthquakes of coda magnitude greater than 1.0 for the offshore Monterey Bay area in the period December 1975 to March 1997. These data were extracted from the Northern California Earthquake Data Center (NCEDC) database. The calculation of new hypocenters is part of an investigation into the characteristics of the San Gregorio fault zone (Ross and others, 1998) This is one of a collection of digital files of a geographic information system of spatially referenced data related to the USGS Coastal and Marine Geology Program "Monterey Bay National Marine Sanctuary Project" . The data were collected and analyzed between 1994 and 2000.


In the paper, a study about induced voltage in the shaft of electrical machines is performed. By finite elements method (FEM) will be made simulations in order to determine these voltages in different conditions. It will consider the rotor shaft eccentricity, its magnetic permeability, the stator winding current, a certain number of broken rotor bars and the stator winding pitch.


We give the classification of (co-)path Hopf algebras and semi-path Hopf algebras with pointed module structures. This leads to the classification of multiple crown algebras and multiple Taft algebras as well as kG-Yetter-Drinfeld modules and Nichols algebras with pointed module structures. Moreover, we characterize quantum enveloping algebras in terms of semi-path Hopf algebras. 2000 Mathematics subject Classification: 16w30, 16G10.


Abstract Inflation and regulation of swim bladder volume enables fish to maintain position within the water column with minimal energy cost. Larvae whose swim bladders fail to inflate must move to stay suspended and would be expected to use additional energy to maintain position. As a relative measure of extra effort expended by fish with uninflated swim bladders, oxygen consumption rates at 26°C were compared for larval Japanese medaka Orvzias latipes with inflated and uninflated swim bladders. During the first 24 h after hatching, oxygen consumption rates were significantly higher for larvae with uninflated swim bladders (1.75 ± 0.13 μg O2·h−1·larva−1) than for those with inflated swim bladders (0.92 ± 0.05 μg O2·h−1·larva−1); after 96 h, oxygen consumption rates had decreased for all larvae to about 0.6 μg O2·h−1·larva−1. For larvae held in sealed containers for 72 h without access to free surface air, the volume of air-saturated water required to maintain an adequate concentration of dissolved oxygen ...


Invaders have often been said to display traits that favor colonisation (r-traits). However, while these traits may allow a species to reach empty habitats before other species do, they are usually associated with low competitive ability. More competitive species, even if they have lower colonisation ability, may prevent the permanent installation of an r-selected invader. Competition rather than colonisation may therefore limit invasion. The best situations to test this hypothesis are "invasive series", when successive invasions by related taxa occur in the same place. Phylogenetic proximity of the taxa and common environment ensure that trade-offs between colonization- and competition-oriented traits can be detected. We expect biological traits to change from colonisation-oriented to increasingly competition-oriented strategies along the invasive series. This prediction was tested using two different model systems, both of which invade tropical insular habitats: freshwater snails of the Thiaridae family in Martinique and Tephritid flies in La Reunion. In both systems, in consistency with our hypothesis, the first invaders were relatively r-selected, and were later replaced by new genotypes and/or taxa with increasingly lower fecundity and higher investment per offspring. (Resume d'auteur)


The present invention is a platelet additive solution relates (PAS), the PAS may comprise one or more glycan modifying agent in a quantity of one or more sialidase inhibitors and optionally, salt, citric Sanshiogen, carbon source, and their and one or more PAS components comprise any combination of. The invention also by storing platelets with one or more sialidase inhibitor, a method of extending the in vivo circulation time of isolated platelets, also relates to compositions, and kits. In addition, the present invention decreases the sialidase activity of inhibiting methods and compositions the growth of one or more bacterial platelet product preparations from one or more donors.


Aneurysmal bone cysts are vascular tumors that cause expansion and erosion of bone. We present this rare entity involving maxillary,ethmoid and frontal sinuses along with orbit. Computed tomography and histopathology showed typical features of aneurysmal bone cyst.We discuss clinical, radiological and histological details along with endoscopic management and literature review. The rarity of tumor makesthis case interesting for head and neck surgeons.


IT has been shown previously that there is some definite connexion in wllite rats between the thymus glanid and the gonads, more particularly in the male. In aniimals whlere a condition of hyperthymism had been established, there was found to be marked degeneration of gonads in the nale, and sterility in the female; or-if the animal were young-delayed sexual development.t Furthler experiitients, with x rays, failed to show that any very marked influence is exerted by the thymus directly on the gonads, but irradiation of the testes or ovaries determined liypertrophy of the thymus.2 At the same time clhanges in the pancreas and suprarenal glands were usually observed, and it was to follow up the connexion between the stiprarenal glands, pancreas, tlhymus, -and gonads, tllat the present series of experiments was begun. In the series previously reported it was tllouglht that some of the changes observed in the female miglht hiave been due to the influence of pregnancy rather than to an indirect action of x rays throughi the ovaries. Consequently material has been collected from a large series of pregnant rats at various stages of pregnancy, and the results, it is hoped, will shortly be published. At the same time a series of experiments was begun to investigate directly the functional connexion said to exist between the suprarenal cortex and the gonads. Owing to the difficulty of obtaining fresh material for feeding experimnents, inoculation with various preparations of suprarenal cortx was tried. Full details of the preparations, method of experiment, and findings will be published later, but it wAs thouglht that the following preliminary note might be of interest. White rats only have been used up to the present.


A new neuro-fuzzy classifier, inspired by the min-max neural model, is presented. The classification strategy of Simpson's min-max classifier consists of covering the training data with hyperboxes constrained to have their boundary surfaces parallel to the coordinate axes of the chosen reference system. In order to obtain a more precise covering of each data cluster, in the present work hyperboxes are rotated by a suitable local principal component analysis, so that it is possible to arrange the hyperboxes orientation along any direction of the data space. The new training algorithm is based on the ARC/PARC technique, which overcomes some undesired properties of the original Simpson's algorithm. In particular, the training result does not depend on patterns presentation order and hyperbox expansion is not limited by a fixed maximum size, so that it is possible to have different covering resolutions. A toy problem and two real data benchmarks are considered for illustration.


Abstract It has been estimated that some 6 million tonnes of crude oil is routinely transported by tankship around the world's oceans on a daily basis. Despite the introduction of stringent operating and safety regimes there remains the possibility of an incident occurring that could threaten the waters and shorelines of countries that are in the vicinity of these routes. Shipboard and international contingency plans assume a level of preparedness which may be limited in some of the countries that lay along these shipping lanes. Although the probability of significant oil pollution incidents occurring whilst the vessel is on the high seas is m minimal, they have occurred, some with considerable impact on the areas concerned. Whilst the majority of countries have some form of mutual aid and agreements in place and a number have access to equipment stockpiles, there are still a significant number of areas where there is heavy reliance on local resources. This paper addresses ways in which countries with limited resources can best be prepared for an oil spill and some of the challenges, which this entails.


Norconessine from the seeds of Holarrhena antidysenterica presents close analogies in its pharmacological action to conessine. The absence of a methyl group appears to have relatively little qualitative effect on the general activity of the molecule.


Abstract. Let X and Y be smooth, connected, projective complex curves and let . Let and be two integers. Let and be two partitions of d. In this paper we study equivalence classes of pairs satisfying the following: is a degree d covering of Y, f is unramified at b0 and it is branched in points, n of which are points of simple branching, one is a special point whose local monodromy has cycle type and one is a special point whose local monodromy has cycle type . Moreover, is a bijection and the monodromy group of f is . We prove that the corresponding Hurwitz spaces are irreducible under the hypothesis where and denote, respectively, the genus of X and Y.


ABSTRACT A plane strain analysis of a deformation and stress field in cohesionless granular bodies during shearing in a direct shear tester was performed with a finite element method on the basis of a hypoplastic constitutive law enhanced by polar quantities: rotations, curvatures, couple stresses, and a mean grain diameter used as characteristic length. The constitutive law takes into account the effect of pressure, void ratio, direction of deformation rate, mean grain diameter, and grain roughness on the material behavior. The FE calculations were carried out with a different initial void ratio, vertical load, mean grain diameter, and specimen length. Attention was focused on the size effect caused by the size of microstructure related to the specimen dimensions and the effect of side boundaries on the shear zone formation. The FE results show that the thickness of the shear zone increases with increasing initial void ratio, pressure level, mean grain diameter, and specimen length. Due to the effect of boundary conditions, the thickness changes along a horizontal midsection (it is widest in the mid-region).


A key to improving at any task is frequent feedback from people whose opinions we care about: our family, friends, mentors, and the experts. However, such input is not usually available from the right people at the time it is needed most, and attaining a deep understanding of someone else's perspective requires immense effort. This paper introduces a technological solution.We present a novel method for automatically modeling a person's attitudes and opinions, and a proactive interface called "What Would They Think?" which offers the just-in-time perspectives of people whose opinions we care about, based on whatever the user happens to be reading or writing. In the application, each person is represented by a "digital persona," generated from an automated analysis of personal texts (e.g. weblogs and papers written by the person being modeled) using natural language processing and commonsense-based textual-affect sensing.In user studies, participants using our application were able to grasp the personalities and opinions of a panel of strangers more quickly and deeply than with either of two baseline methods. We discuss the theoretical and pragmatic implications of this research to intelligent user interfaces.


Everybody's business? what is depression? the causes of depressive disturbance associated disorders the assertiveness link depression due to the premenstrual syndrome postnatal depressive disorders increased risk of depressive illness in married women the disadvantaged mother the effects of postnatal depression on mother-infant relationships and the consequent development of the infant the detection of vulnerability to depression what can be done to prevent postnatal depression support in facilitating emotional well-being prevention of depression caused by maternal exhaustion preventing depression caused by stress detection of depression a multidisciplinary approach for the detection and management of depression communication skills why depression is missed physical treatments the counselling approach a new initiative - the development of a self report scale.


Based on the two hail processes during June 9,2008 and September 18,2008 in Lijiang,we use doppler weather radar data to make the detailed comparative analysis;①found the environmental wind field which triggered the hail of Lijiang;② summaried ZhongDa shape the intensity field cumulus clouds billow stage,mature stage,die stage of echo and the vertical section features;③ analyzed the strongest of each period echo velocity between layers of elevation of inflow and outflow situation;④used the characteristics of radar second production for inspection,and diagnosed the strength of the storm.Eventually form the early warning system of intense convective storms which will happen around Lijiang.It's the foundation for guiding the weather forecast and early warming of the process of strong convective in the future.


Contribution of Potassium Channels to Myogenic Response in Skeletal Muscle Arterioles: Effects of Age and Fiber Type. (August 2005) Se Jeong Kim, B.Ed., Kyungsung University; M.Ed., Yonsei University Chair of Advisory Committee: Dr. Judy Muller-Delp In isolated skeletal muscle arterioles, increasing transmural pressure causes an increase in constriction. This active myogenic response varies with age and fiber type. Increased transmural pressure activates both Ca-activated (KCa) potassium channels and voltage-dependent (Kv) potassium channels; these channels have a role in the negativefeedback pathways that modulate depolarization and myogenic constriction. We tested the hypothesis that increased KCa channel and Kv channel activity contribute to reduced myogenic responsiveness in skeletal muscle arterioles of aged rats. 1A arterioles were isolated from soleus, an oxidative muscle, and superficial gastrocnemius, a glycolytic muscle, of young (4 mos) and aged (24 mos) Fischer 344 rats. Myogenic responses were assessed by increasing intraluminal pressure (0-140 cm H2O) in increments of 20cm H2O. Vasoconstrictor response were determined in response to increasing concentrations of the KCa channel blocker, charybdotoxin (CTX; 10 to 10 M) and the Kv channel blocker, 4-Aminopyridine (4-AP; 10 to 10 M). To determine the role of potassium channels in modulating the myogenic response, cannulated arterioles from soleus and gastrocnemius were incubated with CTX (50 nM) and 4-AP (5mM) for 15 minutes prior to evaluation of the myogenic response. Increased Kv channel activity contributes to reduced myogenic


Graph spectral clustering algorithms have been shown to be effective in finding clusters and generally outperform traditional clustering algorithms, such as k-means. However, they have scalibility issues in both memory usage and computational time. To overcome these limitations, the common approaches sparsify the similarity matrix by zeroing out some of its elements. They generally consider local neighborhood relationships between the data instances such as the k-nearest neighbor method. Although, they eventually work with the Laplacian matrix, there is no evidence about preservation of its spectral properties with approximation guarantees. As a result, in this paper, we adopt the idea of spectral sparsification to sparsify the Laplacian matrix. A spectral sparsification algorithm takes a dense graph G with n vertices and m edges (that is usually O(n2)), and returns a new graph H with the same set of vertices and many fewer edges, on the order of O(n log n), that approximately preserves the spectral properties of the input graph. We study the effect of the spectral sparsification method based on sampling by effective resistance on the spectral clustering outputs. Through experiments, we show that the clustering results obtained from sparsified graphs are very similar to the results of the original non-sparsified graphs.


Objective ToinvestigatetheHPV16 E6 genemutationincervicalcarcinomatissueinNingbodistrict.Methods Eighty cases were divided into two groups according to the patients' age at diagnosis: group A(37 cases,at age≤35)and group B(43 cases, at age 35). The HPV viral genomic DNA was extracted from the paraffin section of cervical cancer tissue. HPV 16 E6 DNA was amplified by PCR technique sequenced. Results The positive rate of HPV 16 E6 gene was 43.75%, respectively 56.76% in group A and 32.56% in group B. The difference was statistically significant( 0.05). Compared with the DNA sequence of German standard strain, the results showed that nine mutation types were detected, of which the mutation rate was highest in site 178, but the difference was not statistically significant between two groups( =0.70). Conclusions The prevalence of the cervical carcinoma caused by HPV 16 tends to be younger. T178G mutation may be an important factor of HPV 16 persistent infection. More attention should be paid to this mutation type for prevention and treatment of cervical cancer.


The first university-based degree programme in public relations in the Russian Federation was organized at the St. Petersburg State Electrotechnical University. It is currently in the process of developing increased curriculum emphasis on integrated communications. To meet the requirements of the Twenty-First Century, public relations educators and practitioners must be prepared to teach and practice integrated communications. The primary mission of universities and colleges is the teaching of students, but there are other equally important tasks to be integrated into public relations education, such as the preparation of students for careers in a profession. Ongoing contact and involvement with professional practitioners and organizations is a vital for university programmes that prepare public relations specialists.


The V1−xMoxO2 phase diagram has high structural and electronic complexity that is driven by strong, short-range correlations that compete with the long-range rutile crystal structure. The substitution regime near 50% Mo occupancy is no exception, but there has so far been no significant progress in determining the actual structure. Reported here is a combined study using single crystal X-ray diffraction, powder X-ray diffraction, and representational analysis to examine both the local and crystallographically averaged atomic structures simultaneously near x = 0.50. Between about x = 0.50 and 0.60, the average structure of V1−xMoxO2 is the parent rutile phase, but the local symmetry is broken by atomic displacements that are best described using the orthorhombic subgroup Fmmm. This model is locally similar to the two-dimensionally ordered 2D-M2 phase recently reported in the compositional range 0.19 ≤ x ≤ 0.30, except the correlation length is much shorter in the 2D plane, and longer in the frustrated one, making it more isotropic. This work also extends the 2D-M2 phase regime up to x = 0.43, and suggests that the local-Fmmm phase observed here can be seen as the end result of the continued suppression of the 2D-M2 phase through enhanced geometric frustration between the intrinsic order parameters. This suggests that other doped-rutile phases with elusive structures may also be dominated by similar short-range correlations that are hidden in the diffuse scattering.


Triphenyltin-1,1,2,3,3-pentacyano prophenide compound, [(C 6 H 5 ) 3 Sn][C 3 (CN) 5 ]2H 2 O, is the stable organometallic complex, which is a macromolecule compound. This compound is synthesized from triphenyltin chloride, (C 6 H 5 ) 3 SnCl, and silver pentacyano prophenide, AgC 8 N 5 , in tetrahydrofuran (THF). This compound has crystal system of monoclinic with space groups of P2(1)/n with a = 825.37(10); b = 2092.91(03); c = 1484.07(10) pm, a = g = 90,00° and b =103.84(10) o ; and cell volume = 2.49(05) nm 3 . The compound consists of [C 3 (CN) 5 ] - anion and [(C 6 H 5 ) 3 ] + cation in slightly different packing modes.


Mental health a component of holistic definition of health by World Health Organization (WHO) has been receiving increased attention in the recent times. Perceived Social Isolation (PSI) as an area of research attracted tremendous attention in recent times. Social isolation, has been identified as a state in which individuals lack a sense of belonging, true engagement with immediate family, friends, peers in the form of fulfilling relationships and is found to be associated with negative health outcomes. The two components of social isolation include 'objective' and 'subjective' forms. The objective form of social isolation results due to actual lack of social ties wherein individuals lack the social systems such as family, community belonging etc. The subjective form commonly identified as 'perceived social isolation' arises from a feeling of lack of engagement with the above said systems available in one's living environment. This form of social isolation has been linked to adverse physical and mental conditions in individuals experiencing it. ABSTRACT


ICT service-providers are to daily face the problem of delivering ICT services (data processing (Dp) and/ or telecommunication (Tlc) services) assuring the best compromise between Quality of Service (QoS) and Energy Optimization. Indeed, any operation of saving energy involves waste in the QoS. This holds both for Dp and for Tlc services. This paper introduces models the providers may use to support their decisions in the delivery of ICT services. Dp systems totalize millions of servers all over the world that need to be electrically powered. Dp systems are also used in the government of Tlc systems, which also require Tlc-specific power, both for mobile networks and for wired networks. Research is thus expected to investigate into methods to reduce ICT power consumption. This paper investigates ICT power management strategies that look at compromises between energy saving and QoS. Various optimizing ICT power management policies are studied that optimize the ICT power consumption (minimum absorbed Watts), the ICT performance (minimum response-time), and the ICT performance-per-Watt.


A new study concludes that financial insecurity produces physical pain. Our pain blogger thinks the business-school authors may have oversimplified.


Purpose - The purpose of this paper is to assess whether internal audit role and reporting relationships affect investor perceptions of disclosure credibility. Design/methodology/approach - The experiment involved a 2 × 2 design with internal audit role and reporting relationship randomly assigned among 84 MBA students serving as proxies for nonprofessional investors. Findings - The results indicate that participants perceived disclosure credibility to be significantly higher when the Chief Audit Executive reported functionally to the audit committee and administratively to the CEO (versus both strategically and administratively to the CFO). The results reveal no significant differences in perceived disclosure credibility from the differing audit roles (i.e. primarily assurance versus primarily consulting). Originality/value - The findings contribute to the internal audit and corporate governance literatures by providing further evidence of the importance of internal audit in investor judgement and decision making.


This paper presents testability optimizations for a dynamic reconfigurable CPLD (Complex Programmable Logic Device) architecture for structured ASIC technology. A CPLD architecture controlled by on chip memory can be built on structured ASIC technology to eliminate the drawback of fixed wire routing. In this paper we analyze the test coverage loss due to use of memory bits to control the logic functions and propose solutions to regain the coverage with no area and timing penalty. When compared to other synthesizable programmable cores ideas, our implementation show test coverage improvement with no area increase and performance degradation.


Based on the social and economic foundation as well as the political background of Negotiable Instrument Law of the People's Republic of China,this article analyzes the historical roots,logic origination,content,rationality and theoretical foundation of the non-causation principle of negotiable instruments,points out the legislative defects and its betterment,so as to rationalize the non-caution principle and perfect our negotiable instrument law.


Aiming at the difficulty faced by Quantum–inspired Evolutionary Algorithm(QEA) in solving actual problems,this paper presents an improved QEA,and applies it to the TSP.Combining with the improved QEA,an arbitrarily searching encoding method of Hamiltonian cycle is proposed.The computation results of problems from TSP database indicate that the performance of improved QEA is superior to that of the conventional QEA and the immune evolutionary algorithm.


The purpose of this study was to determine prevalence and degree of gastrointestinal helminth infections in timor deer and axis deer in the Pendopo Tulungagung. The research was conducted in June-July 2014 with 24 faecal samples, and were analyzed the samples at the Departement of Parasitology Veterinary, Faculty of Veterinary Medicine, Universitas Airlangga. On examination it was found some kinds of worm eggs, which are Bunostomum spp., Oesophagostomum spp. and Cooperia spp. The results of the study showed prevalence of gastrointestinal worms of 29,17 %.In the calculation of worms eggs per gram feces obtained the number of worms that infect the eggs ranges from 0-500 and relatively mild degree of infection. The results of the analysis used relative risk, timor deer and axis deer have the same opportunity for a positive outcome of gastrointestinal helminth infections, and Mann-Whitney U test showed no significant differences degree of gastrointestinal helminth infection of timor deer and axis deer (p>0,05).


Unexpected light propagation effects, such as negative refraction, have been reported in artificial media. Leveraging on the intersubband resonances in heterostructured semiconductors, we show that all possible optical regimes, ranging from classical dieletric and metal to hyperbolic metamaterial types 1 and 2, can be achieved. As a demonstration, we prove that the negative refraction effect can occur at a designed frequency by controlling the electronic quantum confinement.


If the dimension of M is denoted by 2k - 1 or 2k, then a generic map F: M → C k satisfies dF 1 A... A dF k ≠0, while in certain cases there is no map F: M → C k+1 that satisfies dF 1 A... A dF k+1 ≠ 0.


(57) Abstract: composite material doctor blade of the multilayer structure (10) is provided with a cutting edge portion that is configured to pressed against the surface of a rotating roll in a paper machine. Doctor blade (10) is provided with an inner core (28) and the intermediate layer (30, 32). Doctor blade (10) can also include external layer. The inner core mainly consists of polymeric materials. It is included reinforcing fibers in the intermediate layer provided on both sides of the core. Cutting edge of the doctor blade, the wear resistance scale as measured by ASTM Test Method D5181-91 has about 4.0 to 5.0.


— Modern day education and learning has moved on from brick and mortar institutions to open learning environments. Massive Online Open Courses (MOOCs) are a perfect example of these learning environments. MOOCs provide a cost and time effective choice for learners across the globe. This has led to new challenges for teachers such as providing valuable and quality assessment and feedback on such a large scale. Recent studies have found peer assessment where learners assess the work of their peers to be a viable and cost effective alternative to teacher/staff evaluation. This study systematically analyzes the current research on peer assessment published in the context of MOOCs and the online tools that are being used in MOOCs for peer assessment. 48 peer reviewed papers and 17 peer assessment tools were selected for the comparison in this study and were assessed on three main dimensions, namely, system design, efficiency and effectiveness. Apart from these dimensions, the study highlights the main challenges of peer assessment. In the light of the comparison and discussion of current research in terms of the identified dimensions, we present future visions and research perspectives to improve the peer assessment process in MOOCs.


The welfare states in Europe are confronted with a twofold challenge. Both internal changes such as the ageing of our societies and external developments such as globalisation and European economic integration are threatening the viability of many welfare state policies. What can the European Union do to support domestic welfare states in coping with these challenges? The paper first provides an overview of the historical evolution of EU social policy and its current state of affairs. Then, it presents the innovations in the areas of social policy introduced by the EU's constitutional treaty and discusses their likely effects. The new provisions may be used to loosen the tight grip of the EU's internal market rules on domestic welfare states, and they offer ample opportunities for the ECJ to further the development of supranational social regulation by case law. In order to explain these outcomes, the paper analyses the controversial debates in the European Convention, revealing that the cleavages within the Convention ran along national but also to a significant degree along party political lines.


This study aimed to develop epoxy putty as a multi-purpose connection and restoration material that can be used for material-specific restoration work such as metal, wood, ceramics, earthenware and stone artifacts by replacing synthetic resins currently being used for preservation treatment of cultural assets. Existing synthetic resins have the issue of cutting force resulting from high strength, deflection resulting from long hardening time, contaminating the surface of artifacts through staining on tools or gloves and need for re-treatment resulting from material discoloration. Accordingly, paste type restoration material most widely being used in the field of cultural assets preservation treatment was selected and examined the property to select it as an object of comparison. Based on such process, epoxy putty was developed according to the kind of agent, hardener and filler. For the purpose of solving the issues of existing material and allowing the epoxy putty developed to have similar property, property experiments were conducted by selecting agents and hardeners with different characteristics and conditions. The study findings showed that both kinds are paste type that improved work convenience and deflection issue as a result of their work time of within 5~10 minutes that are about 3~10 times shorter than that of existing material. In regards to wear rate for increasing cutting force, it improved by about 3 times, thereby allowing easy molding. For the purpose of improving the issue of surface contamination that occurs during work process, talc and micro-ballon were added as filler to reduce the issue of stickiness and staining on hand. Furthermore, a multi-purpose restoration material with low shrinkage, low discoloration and high cutting force was developed with excellent coloring, lightweight and cutting force features.


Abstract A general conjecture is given for an explicit basis of the coordinate ring of the closure of the conjugacy class of a nilpotent matrix. This conjecture is proven when the partition given by the transpose Jordan type of the nilpotent matrix is a hook or has two parts.


The invention discloses a computing method for held-to-maturity investment on basis of Excel finance modeling. The computing method comprises the following steps: designing a basic data input interface and designing a data computing area interface and a corresponding computing formula. According to the computing method provided by the invention, a computing model is established by utilizing the Excel finance modeling, so that the automation of data computing is realized and the financial accounting work is simplified.


In this paper, a distributed iterative learning control method was proposed for a class of nonlinear multi-agent systems consensus tracking, in which the systems trial lengths randomly varying. It is assumed that all agents have the same iterative learning length in one operation; however the operation lengths iteratively varying and a stochastic variable was introduced to describe non-uniform issue. With the control of proposed learning protocol, it is shown that the proposed algorithm guarantees the convergence of tracking error and repetitive multi-agent systems perform high precision tracking performance with randomly varying lengths. An illustrative example further verified the theoretical result.


PURPOSE
To introduce a feasible interstitial rotating shield brachytherapy (I-RSBT) system for treating prostate cancer. With I-RSBT, the radiation sources are surrounded by catheters that contain shields to enable conformal avoidance of healthy tissues, potentially reducing complications relative to conventional high-dose-rate brachytherapy (HDR-BT) techniques.

METHODS
The I-RSBT system is based around ten control cartridges with 9.5 mm × 9.5 mm cross sections. Each control cartridge contains a rotational stepper motor, connected to a lead screw, which drives a platinum-shielded nitinol catheter containing a 37 GBq Gd-153 source. Gadolinium-153 is generated by neutron irradiation of europium-151 or Gd-152 and is mass-producible at reasonable cost. For I-RSBT delivery, the cartridges are arranged in a box-shaped magazine in a desired delivery pattern and aligned with a template containing implanted 16 gauge interstitial nitinol needles. Each source/catheter travels down a needle in a helical pattern during the dose delivery process. An I-RSBT delivery using more than ten needles can be accomplished by dividing the treatment into multiple parts, each with a different cartridge arrangement in the magazine.

RESULTS
Treatment plans based on Monte Carlo dose calculations and optimized using the linear least squares technique demonstrated I-RSBT reduced D1% (minimum dose to hottest 1%) for the urethra and rectum by 20% and 10% respectively, relative to conventional HDR-BT. The prostate D97% was the same for I-RSBT as for HDR-BT. The I-RSBT treatment time for a 20 Gy delivery would be 3 hours with fresh Gd-153 sources. Since Gd-153 has substantially lower gamma ray energies than iridium-192, I-RSBT treatments can occur in procedure rooms rather than conventional brachytherapy suites, reducing the disadvantage of the longer I-RSBT delivery times.

CONCLUSIONS
Treating prostate cancer with I-RSBT is technically feasible in reasonable treatment times using platinum-shielded Gd-153 sources and the proposed delivery system. University of Iowa Research Foundation.


The copper-catalyzed click reaction of O-alkynyl-iodophenols with benzyl- or arylazides affords the triazole ring which is subsequently arylated to provide the title tricycles (36 examples).


Based on the engineering practice of the system already made, the composition and the key function of the GPS vehicle general supervision and control system based on GSM/GPRS remote communication system are described. And the realization of the system is specified into four parts: the wireless communication system through GSM/GPRS, the wired network communication system, the supervision center and the GPS unit on the vehicle. The system is economical,feasible,reliable and practical. Also, advanced technique is used in this well structured system. It is considered to be significant in constructing GPS integrated application system.


This paper is concerned with emergent more-than-human eating practices and how they might challenge received understandings of bioand geopolitics.After a brief review of the anthropology of food and eating and how its concerns may have to be expanded in the Anthropocene, we briefly analyse three empirical cases of anticipatory more-than-human eating practices: a set of artistic anticipations of future eating; microbiome research and related biohacking practices; and research on future food security in the context of planetary boundaries. We discuss how all three cases make the boundaries between body|mind|environment porous. The ›I‹ of the embodied human subject emerges as multiple—colonised and accompanied by a panoply of microorganisms. How might such a collective be subject to governance and 'self‹-technologies? We close by pleading for an experimental para-sitic anthropology that critically addresses emergent forms of bio/geopolitics in the Anthropocene.


The psychological training center in high and low ropes is a space designed for the interaction of a business group, where the corporate environment will find a specific resource that brings special abilities to their employees in terms of leadership, cooperation, conflict resolution, creativity and encouragement for an interpersonal communication, avoiding thereby the exaggerated use of technology. This is achieved by working through high and low rope circuits where the base is the collective support. As yet, there are no spaces in Ecuador created with this purpose, and those few intended to be - especially in Pichincha - have been adapted in hostels, and do not fulfill the requirements and needs that the practice of any of the previously mentioned activities would have. That is one of the main reasons to design a place like this, so the people are able to develop their competitions by means of group dynamics, indoors and outdoors, which will be called "Jananchay Reto Ecuador." Explained in more detail, it has been planned to create specific areas where the participants may spend several nights away from the oppressive consumption of technology while distracting within a natural environment. The intervention will take effect under the concept of "natural refuge" since the objective is to provide with an out-of-the city space that helps users to cultivate their own strength and will. This space is designed to give to the person all the necessary resources that help him to grow mentally, as an individual and also in a work group, everything with the compliance of all the security norms and parameters that cheer the user to step out of his comfort zone. In the construction design is proposed the use of natural materials out, such as wood in floors, plywood in walls, jute fabric in false ceiling, decorations, and walls covered with bamboo and palm leaf in the roof. In conclusion, this project gets to adapt the already existing spaces to the area needed for the center: a place where the user can get away from the rapid pace of the city, and motivate the competitiveness in the entire group, reflecting not only the individual strength but also the collective synergy.


This paper identifies and examines the difference between groupwork and casework in a group setting. Examples of each approach will be used to illustrate the distinction.


Formulae of Berezin and Karpelevic for the radial parts of invariant differential operators and the spherical function on a complex Grassmann manifold are generalized to the hypergeometric functions associated with root system of type $BC_n$ under condition that the multiplicity of the middle roots is zero or one.


Physical education (PE) is beneficial for the development of elementary school-age children through its promotion of different educational learning outcomes, which in turn affects the long-term development of physically active lifestyles. In many countries, PE is taught by classroom teachers (CTs), who are thought to be in a unique position to positively impact students' learning. While a substantial body of studies examines the challenges that CTs encounter when teaching PE, less research has been directed towards gaining a comprehensive understanding of how CTs visualize PE and, in turn, how to promote various types of PE. The purpose of this study, therefore, was to explore elementary school CTs' beliefs about and practices in PE in South Korea. To achieve the research goal, a semi-structured face-to face interview with six CTs was performed to collect the qualitative data source, using the ground theory as an analysis method. Three themes emerged from these interviews concerning the CTs' beliefs in PE: (a) the importance of understanding students' characteristics, (b) the importance of centering internal perceptions in PE method, and (c) the importance of meaningful experiences. The results also identified two themes for teaching practices in PE that corresponded to CTs' beliefs: (a) crafting personalized instructional methods and (b) connecting PE experiences. This study lends important insights to future practices and research recommendations for CTs' PE teaching and teacher education programs.


Observations were made on the responses of the thoracic spiracles of adult Aedes aegypti (L.), and adult A. triseriatus (Say) to a constant CO2 pressure in serial concentrations of O2 in N2 and to the O2 in N2 series alone. Less than atmospheric pressures of O2 caused an increase in the frequency and duration of spiracular opening. Higher than atmospheric O2 tensions had no effect on frequency of spiracular opening, but reduced the duration of opening. Carbon dioxide effected full spiracular opening in proportion to the O2 concentration. The duration of spiracular opening, regardless of amplitude, was also proportional to the ratio of CO2 to O2. Responses of Aedes spiracles to hypoxia and CO2 decreased with increasing duration of exposure.


While the S-alkyl- or S-phenyl-2,3-butadienethioates 4 a-c are synthesized via the usual "Wittig ylide way", the corresponding 2-methyl-2,3-butadienethioates 9 a-d and the 2-methyl-4.4-diphenyl-2,3-butadienethioates 9 e,f are obtained by condensation of the allenic acids 7 a,b with the thiols and thiophenols 8 in the presence of dicyclohexylcarbodiimide (DCC) and a catalytic am ount of 4-dimethylaminopyridine (DMAP). In contrast to N- or O-phenyl 2,3- butadienamides or -esters, resp., the phenyl derivatives of 4 and 9 do not undergo the intram olecular Diels-Alder reaction, but by heating, all representatives of 4 only decompose, while 9 a-d and 9 e,f rearrange to 3-alkyl(aryl)thio-2-cyclobuten-1-ones 12a-d and to 3-arylthio- 1-naphthols 14a, b, resp. Heating of the cyclobutenone 12d in the presence of N-methylaniline furnishes the 2-butenanilide 16. On reacting 1-phenylthio-1-propyne 17 with diphenylketene 18, the diphenylacetate 19 is isolated, where the naphthol derivative 14a represents the ester moiety.


Environmental pollutants have hazardous impact on living organisms as they affect the health of livestock as well as human beings. They have been broadly categorized as heavy metals, pesticides and mycotoxins. Lead, and Cadmium, get deposited in the vital organs through the food chain. Blood being a major medium of transfer of heavy metals into milk and other tissues including meat. It is necessary to assess the levels of these metals in bull blood. Forty random samples of blood were collected from native breed fattening bulls from villages located nearby Assiut City, Assiut Governorate, Egypt were used in this study. Blood levels of lead, cadmium, copper and iron with Inductively Coupled Plasma Emission Spectrometer (ICP). Blood picture were estimated with automatic cell counter. This study revealed that blood levels (ppm) for heavy metals were ranged from 17.49-77.00 for Pb, 0.0142-0.9625 for Cd, 3.424-6.325 for Cu and 385-614 for Fe. All estimated blood parameters were within the normal levels. In conclusion: Despite the presence of potential sources of environmental contaminants containing heavy metals, the level of these metals in the blood of bulls reached the alarming level and continuous monitoring should be done. Necessary action should have to be taken to avoid hazardous situation which may arise in future for betterment of next generation.


(3) [TP ... Subject1 ... [TP PRO1 T-inf ...]] ∗I would like to thank Tonia Bleam, Brian Dillon, Valentine Hacquard and Norbert Hornstein for helpful comments and discussion. Spanish judgments were provided by Edison Barrios, Jorge Guzman, Roberto Reyes Gaskin and Eduardo Sanchez. The audience at the LSA talk made a number of helpful comments. This is a slightly modified version of the handout used for the talk. 1 There are certainly other approaches to be found in the literature besides the two listed here (see e.g. Caballero 2004), but I will not have time to examine them in this talk. 2 There are a number of attempts in the literature to give a principled explanation for this transparency. For example, Picallo (1985) relates it to the subjunctive's lack of an independent tense (citing sequence of tense phenomena). Kempchinsky (1990) relates it to the presence of a null operator which causes T to raise to C in the embedded clause, thus extending the binding domain. A similar idea is presented in San Martin (2007). 3 See e.g. Bouchard (1982, 1983), Farkas (1992) for versions of the competition analysis.


Designing shaped offset Gregorian reflector systems to operate with several interchangeable feed horns, over frequency bandwidths of more than a decade, with multiple, often conflicting, performance figures of merit such as aperture efficiency, receiving sensitivity, sidelobe levels, and cross polarization isolation is a difficult optimization problem. An additional complication may be that the radiation patterns of all the feeds to be used in the system are not known at the time of the dish designs, as upgrades to the feeds may happen throughout the lifetime of large reflector systems. This paper presents a systematic parametric study to quantify the effects of the main causes of performance degradation in such a system, i.e. reflector diffraction and feed pattern variations. First, ideal Gaussian feed patterns are used in order to isolate the diffraction effects, and then the ideal patterns are varied to model the effect of using wideband feeds exhibiting radiation pattern variations over frequency. It is shown that the peak position in the shaping parameter space of the receiving sensitivity is not strongly influenced by diffraction - although the peak value is, as expected, reduced at lower frequencies. This allows similar feed patterns to be used in different frequency bands to still produce systems operating near the maximum sensitivity. When using non-ideal feed patterns it is shown that, for most performance metrics, diffraction effects dominate the feed variation performance degradation in smaller dishes. This allows possibly relaxed requirements on the radiation patterns of feeds used to illuminate electrically small reflector systems.


Abstract:This article provides two new definitions in sports history: first, the sport product, which is seen as encompassing player, spectator, and associated products; and, second, sports entrepreneurship, which covers the four categories of direct income seeking, indirect income seeking, psychic income seeking, and nonprofit promotional activities. Within these categories, attention is drawn to sports entertainment and "dark" entrepreneurs, as well as the historical importance of examining entrepreneurial failure. Two typologies of sports entrepreneurs are presented, one looking at aims and objectives and the other at function. It is argued that sociocultural sports historians should not ignore economic aspects of sports provision.


Abstract The aim of this article is to present a sociolinguistic appraisal of Extremadura varieties among regional dialects of Spanish. Spanish of Extremadura has historically received influences from different linguistic varieties: Castilian, Portuguese, Old Leonese, and, more recently, Andalusian dialects. Extremadura is a territory where the prestigious Castilian fights with popular uses, exhibiting an innovative phonetics, combined with some old phonetic features, especially in the north, and archaisms in the lexical level. It is interesting to note the existence of two linguistic islands in the province of Cáceres: Malpartida de Plasencia and Serradilla.


PATWICK SUPPES T h e ancient Roman architect Vitruvius begins the second chapter of the first book of his The Ten Books on Architecture with the statement that architecture Although the other works on architecture from the ancient world are mostly lost, there is every reason to believe that Vitruvius was stating a commonly and widely accepted view in his emphasis on order, eurythmy, which we may think of as proportion, and symmetry. In the first chapter of Book 3, he also makes the familiar classical assertion that the principles of proportion and symmetry used in architecture are in fact derived from the symmetry to be found in the shape of the human body. He even states his conclusion this way: "Therefore, since nature has designed the human body so that its members are duly proportioned to the frame as a whole, it appears that the ancients had good reason for their rule, that in perfect buildings, the different members must be in exact symmetrical relations to the whole general scheme" [Dover edition, Of In Chapter III of Book 6, Vitruvius gives specific rules for the proportions principal rooms; I cite three typical cases. In width and length, atriums are designed according to three classes. The first is laid out by dividing the length into five parts and giving three parts to the width; the second, by dividing it into three parts and assigning two parts to the width; the third, by using the width to describe a square figure with equal sides, drawing a diagonal line in this square, and giving the atrium the length of this diagonal line. [ 1771 Peristyles, lying athwart, should be one third longer than they are deep, and their columns as high as the colonnades are wide. Intercolumniations of peristyles should be not less than three nor more than four times the thickness of the columns. 11791 Dining rooms ought to be twice as long as they are wide. The height sf all oblong rooms should be calculated by adding together their measured length 352


Bathymetric and regional variation in condition of Icelandic cod Gadus morhua in autumn is compared to that previously observed in spring. Once again, contradicting patterns in the hepato-somatic index and a morphometric index of fish condition were observed. The relevance of this persistent spatial variation in condition in relation to emerging evidence of behavioural types is discussed.


A gel formulation of the antiallergic compound N‐acetyl‐aspartyl glutamic acid (NAAGA) (Rhinaaxia® (R)) has been evaluated in a multicenter, randomized, double‐blind, three‐arm, parallel‐group comparison with placebo gel (P) and disodium cromoglycate (DSCG) in outpatients suffering from seasonal allergic rhinitis (pollinosis). Nose and eye symptoms were assessed daily by the patients on visual analog scales (VAS), and medical examinations were held after 1 week and at the end of the 4‐week treatment. The use of rescue medications (H,‐antagonist (terfenadine) and soothing eye‐drops (Spersallerg®) was recorded as a main assessment indicator of efficacy. For the efficacy analysis, only the periods with relevant pollen concentrations (≥ 50 grains/m3) were considered. The study extended over the two pollen seasons 1989 and 1990. Of 230 included patients, 190 were suitable for efficacy analysis (R = 63, P = 64, DSCG = 63). The VAS data did not reveal a difference between the treatment groups for nasal symptoms, whereas the use of terfenadine tablets was significantly lower in the Rhinaaxia group than in either the placebo (P= 0.0001) or DSCG group (P= 0.03). The eye symptoms were significantly less severe in the Rhinaaxia group than in both placebo (P= 0.0001) and DSCG (P<0.01) groups. In addition, the use of rescue medication was significantly higher in the placebo than in the Rhinaaxia treatment group (P= 0.0001). The incidence of local untoward effects (itching/burning sensation in the nose) was slightly higher in the Rhinaaxia group, while the overall tolerability assessment was similarly good in all three treatment groups. Rhinaaxia gel given three times daily was shown to achieve a satisfactory symptom relief in everyday treatment with a significantly lower need to resort to rescue medication than with placebo and to have a therapeutic effect like DSCG nasal spray given four times daily.


The teachings of Tasawuf have flourished in the Malay world due to the efforts from Malay scholars who studied in Makkah. Muhammad Nafis al-Banjari is one of them. He wrote his treatise on tawhid in a small epistle known as al-durr al-nafis fi bayan wahid al-afcal- wa al-asma' wa al-sifat wa al-dhat al-taqdis . His teaching of tawhid written in Malay Jawi script is embroidered with Sufi teachings. However, his teachings raise issues of controversial and misunderstood nature. One of the contentious issues his epistle is blamed for is regarding the promotion of pantheism having connotation of unity of being (wahdah al-wujud). The objective of this study is to reveal the misconception of tawhid embroidered in the Sufi teachings and the importance of understanding the correct concept of tawhid from the original sources of Islam. This paper employs a detailed historical and textual study. Despite various controversies, al-Banjari epistle is considered to be a valuable work from a historical point of view. His highly succinct explanation requires additional reference and commentaries for readers to acquire appropriate understanding. It is according considered necessary to study his epistle under the proper guidance from the learned shuyookh to conceive it correctly.


With developments in robotics, robots "living" with people will become a part of daily life in the near future. However, there are many problems with social robots. In particular, the behavior of robots can influence human relations, and societies have not yet clarified this. In this paper, we report on an experiment we conducted to verify the influence of robot behavior on human relations using the "balance theory." The results show that robots can have both good and bad influence on human relations. One person's impression of another can undergo changes because of a robot. In other words, robots can construct or collapse human relations.


China's paper making technique has been leading around the world, which has witnessed the development of over two-thousand years since Han and Tang dynasties. The handcraft paper making process in Beizhang Village, Changan, Shaanxi, a remains of the ancient paper making, is in a trend of being forgotten during the evolvement of historic culture and economic development. For the intangible cultural heritages which are gradually disappearing in China, the optimal method to inherit is to industrialize. Based on the status quo and paper making process in Beizhang Village, the article compares the paper making industries between the region and other regions in the country and raises feasible suggestions for the industrialization of handcraft paper making in Shaanxi. The industrialized development is expected to improve the understanding of the public to the handcraft paper making, expand the publicity and increase the economic benefits so as to continue the handcraft paper making process in Beizhang Village, Changan. Keywords—paper making in Beizhang Village; intangible cultural heritages; inherit; industrialized development


The article analyses the issues related to development of Russian economy at the expense of revenues from exports of oil, gas and other raw resources


Summary: A method is described, using the cardioaccelerator response in pithed rats, that distinguishes calcium entry blockers from other agents which have modes of action not involving direct blockade of calcium entry. Diltiazem (0.01–0.3 mg kg−1), verapamil (0.01–0.03 mg kg−1), nifedipine (0.1–1.0 mg kg−1), propranolol (0.003–0.3 mg kg−1), xylazine (0.01–1.0 mg kg−1), alinidine (0.03–1.0 mg kg−1), and, to a lesser extent, lignocaine (0.1–3.0 mg kg−1), reduced stimulation-evoked sustained cardioaccelerator responses in the pithed rat. BRL 34915 (0.3–10.0 mg kg−1) and nicorandil (1.0–10.0 mg kg−1) were without effect in this situation. Infusion of calcium gluconate (1.0 mg min−1) reversed the reduction of the cardioaccelerator responses by nifedipine (1.0 mg kg−1), verapamil (0.3 mg kg−1), and diltiazem (0.3 mg kg−1) but not to propranolol (0.1 mg kg−1), alinidine (0.5 mg kg−1), or xylazine (0.3 mg kg−1). Therefore, calcium gluconate is selective in reversing the effects of calcium slow channel blockers in this model, thereby making it a useful technique for distinguishing these drugs in vivo.


We illustrate the role of the law of diminishing marginal utility in the two main modern utility theories, the ordinal and cardinal utility theories, using a generalised total utility function. In short, the ordinal utility theory, in which utility is immeasurable, must abandon the law of diminishing marginal utility; the cardinal utility theory, although able to retain this law, suffers from keeping the unrealistic view of utility measurability, which Samuelson criticises as "infinitely improbable." A new utility theory with the advantages of the two mentioned theories (i.e. the notions of both diminishing marginal utility and utility immeasurability) but without the disadvantages (i.e. the law of diminishing marginal utility is excluded and utility is measurable) therefore still seems to be a Holy Grail deserving search and development by economists.


As part of a workplace drug-testing policy, a coal-mining company implemented random on-site preliminary urine testing using the OnTrak TesTcup (Roche Diagnostic Systems, Inc.). Presumptive positives were sent to our laboratory for confirmation. A potentially embarrassing situation arose when the mining manager underwent a random test and produced a positive reaction to cannabinoids. He denied using any illicit drugs and claimed to be taking Gemfibrozil (Lopid) for treatment of hypertriglyceridemia. Upon receipt at the laboratory, the TesTcup still showed a positive reaction to cannabinoids. The urine specimen was analyzed for cannabinoids using EMIT TM (Behring Diagnostics) at the 50-1Jg/L cutoff and was found to be negative. The urine specimen was then analyzed for the presence of carboxy-THC using pentafluoropropyl derivatization and gas chromatography-mass spectrometry (GC-MS). No carboxy-THC was detected. The same sample was tested for cannabinoids using the Syva RapidTest (Behring Diagnostics). The test was negative. Gemfibrozil was added to drug-free urine and subjected to the same tests. No false positives were obtained. Urine was later obtained from a healthy subject taking only Gemfibrozil medication. The urine was subjected to the TesTcup (positive), EMIT (negative), and Syva RapidTest (negative). The urine was subjected to a comprehensive drug analysis including EMIT, high-performance thin-layer chromatography, and GC-MS. No drugs other than gemfibrozil were detected. Gemfibrozil is metabolized to hydroxymethyl and carboxyl products. It i~ suggested that one of these metabolites is responsible for the false-positive result of the Roche TesTcup test for cannabinoids in urine.


Strontium zirconate nickelate [(SZN); Sr0.69Ni0.47Zr0.085O3.75] was synthesized through a sol-gel method by adding nickel (II) acetylacetone instead of titanium isopropoxide, which can effectively make thin films smoother and further act as gate insulators applied in pentacene-based thin-film transistors. Sol-gel SZN thin films were investigated by X-ray photoelectron spectroscopy and atomic force microscopy to confirm the chemical composition and smooth surface roughness, and the latter property was found to be compatible for pentacene thin film growth. Thus, the electrical characteristics of pentacene-based transistors exhibited a high mobility of 10.04 cm2 V-1s-1 low threshold voltage of -1.51 V,, and low subthreshold swing slope of 350 mV/decade. To realize high mobility mechanisms, intermolecular coupling and reorganization energy of pentacene thin films were introduced. Another purpose of this introduction was to evaluate the higher hopping rate of carriers between the adjacent pentacene molecules on SZN derived from the March-Hush equation than other high-κ traditional sol-gel insulators.


Reverse time migration (RTM), based on the full solution of the two-way wave equation, is capable of focusing waves beyond the dip limitation of one-way imaging. Although becoming increasingly affordable, RTM is still computationally expensive in practical applications. We present a target-oriented approach to image only a subset volume of interest, potentially reducing runtime and memory cost significantly. As a complementary tool to the traditional full-volume RTM imaging, target-oriented reverse-time migration (TRTM) can be useful to achieving quicker turnaround in defining localized structures of interest.


In order to study the change of temperature on the effects of carbon monoxide absorption spectral lines, first of all proceed from the principle of absorption spectra, using theoretical analysis method, and the transmission and absorption database of the high-resolution molecular educed the carbon monoxide absorption spectrum intensity of spectral lines, integrated widening line type function and absorption coefficient concerned with temperature, then we got the change curve between carbon monoxide absorption spectrum intensity of spectral lines, integrated widening line type function and absorption coefficient with temperature by the numerical simulation of MATLAB, and analyzed and discussed the relationship between the temperature and them .The results showed that the temperature on the effects of carbon monoxide absorption spectral lines, especially on an Integrated widening line type function is complex, and different laser frequencies will also affect the relationship of the line type function and the absorption coefficient change with temperature, which has important reference value for the absorption and measurement of carbon in practical application.


The long intergenic non‐protein coding RNA regulator of reprogramming (lncRNA‐ROR) has been reported to play crucial regulatory roles in the pathogenesis and progression of multiple cancers. However, whether ROR is associated with the initiation and development of osteosarcoma (OS) remains unclear. Here, we found that ROR expression level was significantly up‐regulated in OS tissue samples compared to adjacent normal tissues, and the elevated ROR was closely correlated with advanced tumour‐node‐metastasis (TNM) stage and lymph node metastasis and poor overall survival rate. Functional assays showed that ROR knockdown suppressed the OS cell proliferation, colony formation, migration and invasion in vitro, and retarded tumour growth in vivo. In addition, miR‐206 was verified to be a target miRNA of ROR using bioinformatics online program and luciferase report assay. miR‐206 inhibition partially rescued the inhibitory effects on OS cells induced by ROR knockdown. In conclusion, these results suggested that ROR function as an oncogene in OS by sponging miR‐206 and might be a potential therapeutic target for patients with OS.


Biomathematics use mathematics to quantitatively represent the dynamics of biological or biomedical systems and thereby analyze and predict system behavior. This work addresses an application of bioacoustic modeling and computations to a clinical imaging technique for breast cancer detection. The mathematical model consists in a damped wave equation incorporating a frequency-dependent attenuation, which describes ultrasound propagating in the human breast tissue. 3D numerical simulations are presented to investigate the detectability of breast tumors. An extension to a more general model for the acoustic attenuation is also discussed. For this, 2D numerical experiments are presented to illustrate the issue in the case of the CARI technique.


In this paper,sodium titanate crystal fibers synthesized by hydrothermal method were used as precursors to prepare long lamina anatase TiO2 nano-crystal by further hydrothermal process.The crystal morphology and structure were analyzed using high-resolution TEM and XRD.When pH is 7,the long lamina anatase TiO2 nano-crystal was synthesized,it is 1-2 μm long,100-200 nm wide.When pH is 11,there is some no-reaction nano-tube and membranous substances besides the long lamina anatase TiO2,and it reflect the process of pure sodium titanate nanotubes change to leaf-shaped anatase TiO2.The experiment results show that anatase TiO2 and sodium titanate nano-tube can mutually transfer in hydrothermal condition.


BACKGROUND
Gradual depletion of high-grade ores for heavy metals has encouraged industries to search for alternative methods to recover metals. Wastes generated from metallurgical industries can be used as a secondary resource as it contains high concentrations of metals.

RESULTS
The bioleaching kinetics and biorecovery of zinc from Zn-plant leach residues (ZLR), collected from a currently operating Zn-plant in Tres Marias (Minas Gerais, Brazil) were investigated using sulfuric acid producing Acidithiobacillus thiooxidans (A. thiooxidans). Response surface methodology (RSM) with full factorial central composite design (CCD) was applied to optimize Zn bioleaching by A. thiooxidans. The experiments were performed by varying the initial elemental sulfur concentration (5–30 g L−1), pulp density (5–50 g L−1) and initial pH (3.0–4.0 pH units). More than 75% of Zn was extracted from ZLR by A. thiooxidans under optimized conditions (sulfur concentration 25.1 g L−1, pulp density 21.5 g L−1 and initial pH 3.3). The leaching efficiencies of culture supernatant (biogenic sulfuric acid) and chemical sulfuric acid were compared to understand the leaching kinetics. The Zn leaching kinetics of ZLR followed the shrinking core diffusion model. Zn was selectively recovered from the Fe-rich acidic bioleachate by biogenic sulfide precipitation. Fe was first removed (more than 85% of total Fe in the leachate) by adjusting the initial pH to 5.0, followed by selective Zn biorecovery.

CONCLUSIONS
Zn (>95%) was selectively recovered from Fe-depleted ZLR by biogenic sulfides (with 1:1, Zn:biogenic sulfide mass ratio). Biohydrometallurgy can be a potential alternative resource recovery strategy for the selective recovery of Zn from ZLR. © 2016 Society of Chemical Industry


In the literature there are many definitions of real economic convergence as well as many methods used in verifying the convergence hypothesis. For example Islam (2003) distinguishes 7 types of classifications: (a) convergence within a given economy and convergence between economies, (b) convergence of growth rates and convergence of income levels, (c) β and σ convergence, (d) absolute and conditional convergence, (e) global and local convergence, (f) GDP and TFP convergence, (g) deterministic and stochastic convergence. The concept of income-level or real convergence is widely used by economists. Many theoretical and empirical papers on this subject have emerged in recent years. However, the lack of both one definition of convergence and one method of analyzing this phenomenon yielded a huge diversity of the empirical evidence. The conclusions obtained by various authors depend to a large extent on the analyzed sample of countries, the model specification, and the estimation method. When conducting empirical studies on convergence two problems with the standard approach may be identified. The first one is the stability of the parameters over time. In most empirical studies it is assumed that the impact of a given variable (the initial income level or any other economic growth determinant) is treated as stable over time. It means that the coefficient standing for a given variable is calculated as one value valid for the entire period. Such a model specification, however, does not provide us with the full picture of the factors determining the pace of economic growth. The real world is very complicated, driven by many mechanisms and affected by many shocks, both from the inside and outside sources, so there are no reasons to assume a priori that the relationships between the macroeconomic


To obtain the flow stress data under various deformation conditions,hot compression experiments were conducted on 30 MnSi steel specimens using a Gleeble 1500 thermal simulator.To improve the prediction precision of the flow stress,a new hybrid model——artificial immune least squares support vector machine was proposed.In the hybrid model,the optimal parameters of LS-SVM are obtained by an artificial immune algorithm.The experimental results show that this model can correctly recur to the flow stress in the sample data and can also predict well the non-sample data.The efficiency and accuracy of the proposed model are better than those with BP algorithm used in lot of literatures.Especially, the generalization performance of the model is improved.


Interband cascade (IC) lasers that utilize optical transitions between the conduction and valence bands in a staircase of Sb-based type-I1 quantum wells (QWs) [ 13 represent a new class of mid-IR diode lasers. By combining the advantages of quantum cascade (QC) lasers [2] and type-I1 quantum well interband lasers, type-I1 IC lasers were projected by simulations [3,4] to operate in cw mode up to room temperature with high output power. Although significant advances toward such a high performance level have been reported [5] in terms of high peak output power and power conversion efficiency, the amount of effort expended in developing Sb-based IC lasers is very limited in contrast to other semiconductor lasers such as InPand GaAs-based QC lasers, and their performance is still far from the theoretical projections. Here, we will report the development of Sb-based mid-IR IC lasers at the Jet Propulsion Laboratory.


K. Shmueli, D. L. Thomas, R. J. Ordidge Wellcome Trust High Field MR Research Laboratory, Department of Medical Physics and Bioengineering, University College London, London, United Kingdom Introduction: At high magnetic fields the commonly-used diffusion-weighted imaging technique of spin-echo EPI suffers from susceptibility artifacts which cause geometric distortion and signal drop-out. This means that whole-brain DWI and DTI are likely to suffer from inaccuracies due to artifacts in some regions. It is desirable to reduce the vulnerability of DWI at high field to such artifacts and also to increase the resolution to take advantage of the greater signal available at high field. Here we propose a technique to give high-resolution diffusion-weighted images of a cuboidal region. Selection of a cuboid allows a reduction of the phase encode FOV which therefore allows a trade-off between higher resolution and total echo train length which can be decreased to reduce susceptibility artifacts. The diffusion weighting gradients only have to be applied once for the whole set of slices within the selected cuboid. In this way the gradient 'on' time is reduced in comparison with other 'single-shot' diffusion-weighted techniques such as ZOOM-EPI [1,2], STEAM-FLASH [3] and DW-RARE [4]. A further advantage of this technique over the ZOOM-EPI technique is that the slices can be much closer together. The STEAM-EPI sequence should also require much less RF power than the FLASH and RARE techniques. In this work, preliminary experiments are carried out to show that DW-STEAM-EPI is feasible and gives accurate diffusion coefficients. It is hoped that the technique could be used to focus in on specific brain regions in which the higher resolution could allow clarification of fibre crossings in DTI.


Introduction: The cardiovascular diseases are the principal cause of death worldwide and a public health problem in Colombia. From the cardiac related illnesses, the most frequent is the Acute Coronary Syndrome (ACS). One of its risk factor is high plasma levels of homocysteine. The enzyme Paraoxonase 1 (PON1) hydrolyzes Homocysteine-thiolactone, producing homocysteine, avoiding damage to endothelium related to Homocysteine-thiolactone. Two genetic variants in PON1 gene have been associated with levels of homocysteine and acute coronary syndrome. Objective: to determine the relationship between the polymorphisms Q192R and L55M from gene PON1 and the levels of homocysteine, HDL, apo A-1 and the enzymatic activity of Paraoxonase I in patients who suffered acute coronary syndrome. Methods: sixteen unrelated patients with Acute Coronary Syndrome (ACS) and sixteen healthy controls were enrolled. The paraoxonase activity, levels of homocysteine, HDL and apo A-1 were assessed. The DNA polymorphism analysis was performed using Polymerase Chain Reaction (PCR) and digestion with restriction enzymes. Results: levels of homocysteine are higher in cases (p<0.0001) and the genotypes 192RR and QR are associated with higher levels of homocysteine (p=0.0234). Conclusion: polymorphisms in PON1 gene could be related to homocysteine levels in Acute Coronary Syndrome patients.


A Sn-doped Ga2O3 thin film was deposited on a n+-Si substrate by metal-organic chemical vapor deposition. The Ga2O3 film was found to be amorphous-like and exhibited n-type conduction with Sn doping. Room-temperature electroluminescence was clearly observed from the Sn:Ga2O3/n+ -Si diode, including an ultraviolet (UV) emission at ~ 370 nm, a yellow emission at ~ 580 nm, and a red emission at ~ 680 nm. The UV emission is assigned to the transition from SnGa donor to the VGa acceptor, whereas the visible emissions were assigned to be related to the dangling bond defects.


(B4C/C)-β-PbO2 electrodes were prepared by high-pressure molding technique and characterized by X-ray diffraction, scanning electron microscopy, polarization curves, cyclic voltammetry curves, and corrosion resistance test. In this paper, the effects of initial concentration, current density, electrolyte concentration, pH, and electrode spacing on tetracycline hydrochloride (TCH) degradation were investigated. Results indicated that modified electrode had high electrochemical activities, high oxygen evolution potential, and excellent corrosion resistance. The maximum removal rate of TCH could reach 90.87% at initial concentration of 300 mg/L after 120 min electrolysis with Na2SO4 concentration of 0.2 mol/L, electrode spacing of 1 cm, current density of 30 mA/cm2, and pH 3. Pseudo-first-order kinetics equation was followed during electrocatalytic degradation of TCH with 20%(B4C/C)-β-PbO2 electrode.


The determination method of EAQ and H4EAQ content in the working solution of palladium catalyst selective evaluation in the production of hydrogen peroxide by anthraquinone process through second derivative polarographic method is founded.It overcomes the defects of low distinguishablity and high error during determining the EAQ and H4EAQ content by general polarographic method,and clearly separates the polarographic wave of EAQ and H4EAQ.By adding proper deoxidant,it can effectively avoid the disturbance of oxygen wave,improve the waveform and inhibit the appearance of polarographic maximum peak,then realize the accurate determination of EAQ and H4EAQ content in working solution.During determining EAQ and H4EAQ content by this method,the relative errors are +4.6% and +4.3% respectively,the relative standard deviations are 2.1% and 1.7% respectively,the detection limits are 4.1 mg/L and 1.7 mg/L respectively.


[FROM A CORRESPONDENT.] THE NEW UNIVERSITY. THERE appears to be no reason to doubt that on or soon after May 16th the statutes presented to Parliament by the University of London Commissioners will receive the Royal assent and will become law. The Vice-Chancellor will at once arrange for the election of the Senate, which body will probably hold its first meeting some time in June; but " statutes and regulations will not make a living university " out of a number of independent competing institutions. The Senate, formed largely by the representatives of examining and teaching institutions, must, if it is to succeed in doing anything of value, have the cordial support of the institutions, the work of which it is desired to co-ordinate and develop. One might therefore have expected that during this latent period the various groups of institutions interested in the formation of the Teaching University would have organised some means of exchanging views and of arriving at a decision as to the course most likely to lead their own department of the University to the highest point of excellence.


Breakdown of woody debris in river and upland habitats as well as the interactions between wood and invertebrates have been well described. Studies of wood in wetlands are rare, and far less is known about breakdown and invertebrate use of wood in these transitional habitats. This study experimentally assessed breakdown and invertebrate colonization of wood in a floodplain wetland and directly related patterns in the wetland to adjacent river and upland habitats. Over a 2.7 year period, we monitored breakdown and invertebrate presence in 10 cm diameter × 150 cm long sweetgum (Liquidambar styraciflua L.) logs in a floodplain wetland (n = 8), river (n = 5), and upland (n = 4) habitat. Mass loss, decay condition change, and C/N ratios of wetland wood more closely resembled upland than river wood. The overall invertebrate assemblage associated with wetland wood was also more similar to that associated with upland than river wood. Breakdown and invertebrate colonization of wood in the floodplain wetland shared...


In commercials and motion pictures, computer graphics is often used to achieve special effects, e.g., adding synthetic dinosaurs in "Jurassic Park". This process usually implies special camera equipment and a careful and time consuming post processing of single frames. We consider a simplified scenario, where synthetic objects are added automatically to a live scene in real-time. Reference points are identified interactively in the first image and tracked in the image sequence in realtime. The camera settings including the camera position are calculated from these points. Therefore, a shot with moving camera can be handled which cannot be done satisfactorily with other current systems. The camera data is used for generating the appropriately transformed synthetic object at the correct place in the video. The whole process has to be performed within the video cycle of 1/25 sec which asks for specially optimized algorithms.


Analyzes the interface interchange and the way of OPC data access.Considering the shortage of OPC data access in tradition, proposes a memory method and implement it, which is capable of using the linear linked list for a few amount of data and using the chained harshed list for a large number of data ,and using the chained harshed list with headnode for client data. The test which was done is used to illustrate the availability of the proposed method.


Summary Pain management in endometriosis Therapy of endometriosis related pain can be a challenge even for the experienced clinician. Common endocrine methods of treatment can be considered as more or less equivalent. The choice of therapy should take life-style and other circumstances (e.g. family planning), sideeffects and costs of the medication into account. Most clinicians will chose oral contraceptives (OC) and NSAIDs in the treatment of endometriosis related pain. One possible treatment might be low dosage OC, given non-stop. Progestagens may be helpful, either orally, as depot-injection or as an intrauterine device. In severe diseases (rASRM III or IV) GnRH-agonists combined with add-back-therapy are recommended. These recommendations must be varied according to individual patient characteristics and needs. If drug treatment is not successful surgery should be considered, and if necessary, followed by a new trial of drug therapy. Prescription of opioids and other co-analgetics, and neuroablative surgery should be viewed as a last resort. These options should only be considered after thorough investigation of all treatment options, consultation with a pain management specialist, an experienced surgeon and possibly a psychotherapist.


The focus of the current issue 1-2/2016 of GMS Medizin – Bibliothek – Information is on the future of ZB MED. The authors of the focus articles are Klaus-Rainer Brintzinger (ZB MED: What value comes to library infrastructure within science?), Iris Reimann (The importance of ZB MED for the German MLA / AGMB) and Bruno Bauer (No future for ZB MED! Or maybe: a future for ZB MED?).

Furthermore this issue features articles from Maurizio Grilli (A practical method for systematic searching of literature in medical libraries), Oliver Obst (Use of tablets for the study of medicine. Part 2: The project easyphysikum), Jana Possel (Usability test of the new ZB MED search portal LIVIVO), Holger Laube, Alena Ittner, Sandra Pfob and Alexander Schroder (Fast as lightning to literature: ordering of literature in flow), Iris Reimann (German MLA (AGMB) News) and Bruno Bauer (The Medical Librarian's Bibliography 2015).


For the purpose to evaluate the security of wireless networks,we have to consider many evaluation indexes,many factors are ambiguous and relative.Therefore it is difficult to achieve quantitative assessment requirements intuitively by using traditional methods of risk evaluation.This paper proposes a model based on analytic hierarchy process(AHP) and gray clustering.Firstly by analyzing various security indexes hierarchically,we can quantify the weight of indicators of every layers,and then using the gray clustering to get clustering analysis,finally,we can determine the network security situation through obtaining risk clustering indexes.This method is proved to be efficient in wireless network security risk assessment.


Objective To investigate the lead pollution and its impact on children's blood lead concentration in a battery recycling factory. Methods An occupational hygiene survey was conducted in a battery recycling factory.Thirty-five children and their parents were investigated. Blood lead concentration of the children and lead concentration of factory atmosphere were tested. Results The concentrations of lead dust and smog of workshop were(0.217±0.135)mg/m3 and (0.242±0.247)mg/m3,which exceeded acceptable ranges in 100.0%(5/5)and 87.5%(14/16)of sampled areas respectively.Lead concentration of atmosphere was(18±6)mg/m3 in children living area.None of sampled specimens of atmosphere had acceptable concentration of lead and the maximum lead concentration was 22 times higher than acceptable range.An average blood lead concentration of children was(271.64±106.78)μg/L.High,slight,moderate blood lead concentration and lead poisoning were found in 20.0%,28.6%,45.7% and 2.8% of children in the factory respectively,and there were no differences between boys and girls. Conclusion There was serious lead pollution in the area where the factory was located.Law enforcement should be performed to force the factory to take control measures immediately for preventing the lead pollution.Effective stategies have to be taken to decrease the blood lead concentration of children in the area especially.


Three-dimensional elasto-plasticity non-linear finite element method is applied in the emulation analysis of dam stress and deformation during the actual casting,arch closure and reservoir water filling processes,and the deformation of abutment inter-laminar dislocation band is analyzed at the same time.The calculation results show that the dam deformation during construction is small,the FEM equilibrium stress of dam can satisfy the requirement of specification,and the deformation of abutment inter-laminar dislocation band is slight.So the design of the dam structure is rational,and there is no risk for failure at the abutment inter-laminar dislocation band.The study can provide technique support for project construction,and reference for similar projects analysis.


* Acknowledgements * Introduction * Chapter 1 - Transporting Citizenship * Chapter 2 - Sell it to Save It * Chapter 3 - The Traffic * Chapter 4 -Wired on the Islands * Conclusion * Notes * Suggestions for Further Reading * Index


Glass forming ability and crystallization kinetics of Al-Mg-Ni-La alloys have been investigated by X-ray diffraction (XRD) and differential scanning calorimetry (DSC). The maximum thickness achievable in glasses of Al76Mg11Ni8La5 and Al69Mg18Ni8La5 ribbons were 200 and 120 μm, respectively. The crystallization temperature and peak temperature indicated by DSC measurements displayed dependence on the heating rate during continuous heating, and were coincident with Lanoka's relationship. The activation energies for the crystallization reaction Ex were obtained from the Kissinger's equation. The results show the Mg addition is beneficial to the thermal stability of the amorphous phase.


Several types of research showed math anxiety as the learning outcome, but another showed that as the predictor variable. Math anxiety was predicted based on other variables, such as self-regulated learning and self-concept. Self-regulated learning is associated with academic achievement. This study aimed to obtain valid and significant indicators of each latent variable and to develop the structural model of those latent variables on students' academic achievement. The research used an interval scale questionnaire to measure all latent variables except academic achievement. The PLS-SEM was applied by SmartPLS software. The structural model showed that math anxiety directly affected academic achievement but indirectly affected self-regulated learning, which is self-concept as the mediating variable. For students with low math anxiety, their self-regulated learning tends to be high by controlling their self-concept in math.


A method for the optimum design of manipulator workspace is provided based on a recently established criterion. Analytical and computer-aided procedures are presented for the determination of the geometrical proportions of a manipulator for optimum workspace. An effective algorithm is developed by combining a heuristic optimization technique and a computer program for kinematic analysis of manipulators. Two problems are investigated. The first is concerned with the optimum design of a manipulator that has three revolute joints and a spherical joint at the wrist, called the RRRS manipulator; the second is concerned with the problem of design improvement for five commercial robots for larger workspace volume. The potential applicability of the procedure is demonstrated.


The economic power dispatch (EPD) problem aims to find the optimal operational settings of power generating units with minimizing the entire production costs of generation and all system constraints are kept into their acceptable limitations. Meanwhile, achieving this economical operation based on the reduction of the fuel cost and fossil fuel fired power plant emission should be as little as possible. Another nonlinear framework, with contradictory objectives, called combined economical emission power dispatch (CEEPD) is considered as the target framework in this study. The CEEPD framework is subjected to a set of operational equality and inequality constraints. In terms of the solution methodology, this paper is focused at developing a novel optimization algorithm called Chaotic Krill Herd Algorithm (CKHA) as an efficient tool for solving non-convex EPD and CEEPD frameworks. The proposed CKHA is tested on several IEEE test systems for refining its convergence and therefore aggregating the overall solution method. The numerical results clearly show the dominance of CKHA in finding the competitive best fitness functions compared with the advanced methods those published in the literature.


Purpose Tigecycline is an agent for carbapenemase-producing Klebsiella pneumonia (KPC-KP), given its penetration into lung tissues. Our study focused on the molecular and clinical efficacy of tigecycline for hospital-acquired pneumonia (HAP) in the ICU. Patients and Methods A retrospective cohort study of 52 adult KPC-KP HAP patients by searching hospital medical records from January 2018 to December 2020 was established to investigate the epidemiology of KPC-KP infections for tigecycline treatment and the associated clinical efficacy of tigecycline. The KPC-KP isolates underwent multilocus sequence typing. Molecular typing, antimicrobial resistance, and virulence profiling were also analyzed by whole-genome sequencing of KPC-KP. Results Among 52 patients with KPC-KP, the ICU mortality rate was 14/52 (27%), and there was no significant statistical difference in mortality between the effective group and failure group (p = 0.754). However, the duration of tigecycline was statistically different between the two groups of patients (14.4 vs 10 days, p=0.046). The total bacterial clearance rate was 6/52 (11.5%). There was no significant statistical difference in both groups (p=0.416). Antibiotic resistance genes (aac3iia) and virulence gene (AREO-iutA, Capsule-wzc) were negatively correlated with clinical efficacy (p = 0.011, OR = 1.237). Conclusions Blakpc was the main carbapenemase in all K. pneumoniae strains. ST11-KL64 KPC-KP was the most common virulence factors in KPC-KP isolates. This study suggested that antibiotic resistance genes (aac3iia) and virulence gene (AREO-iutA, Capsule-wzc) were independent mortality risk factors for patients with Klebsiella pneumoniae carbapenemase-2 producing K. pneumoniae infections, when during the tigecycline treatment. Molecular analysis of K. pneumoniae may provide an option when choosing the antimicrobial treatment.


With the advantages of responsive shape memory property, fast response speed, multiple triggering strategies, and the remote control possibility, novel shape memory graphene (SMG) materials are able to gain fundamental success and play a great role in many areas. In this perspective, we will overview the cutting-edge achievements of SMG materials, including their latest fabrication approaches, triggering strategies, and typical applications, and discuss the future outlook of SMG.


The digitalization of asset management in universities is an important method to improve the efficiency of management. At present, with the gradual maturity of two-dimensional code scanning technology, two-dimensional code technology provides a new direction for university management and has great significance for improving the management efficiency of fixed assets in universities. After analyzing the basic characteristics of two-dimensional code technology, aiming at the current situation of asset management in universities, we design the application plan of two-dimensional code technology in fixed assets management in universities to provide some references for relevant researchers.


Robotic Wire Arc Additive Manufacturing (WAAM) utilizes a robot arm as a motion system to build 3D metallic objects by depositing weld beads one above the other in a layer by layer fashion. A key part of this approach is the process study and control of Multi-Layer Multi-Bead (MLMB) deposition, which is very sensitive to process parameters and prone to error stacking. Despite its importance, it has been receiving less attention than its single bead counterpart in literature, probably due to the higher experimental overhead and complexity of modeling. To address these challenges, this paper proposes an integrated learning-correction framework, adapted from Model-Based Reinforcement Learning, to iteratively learn the direct effect of process parameters on MLMB print while simultaneously correct for any inter-layer geometric digression such that the final output is still satisfactory. The advantage is that this learning architecture can be used in conjunction with actual parts printing (hence, in-situ study), thus minimizing the required training time and material wastage. The proposed learning framework is implemented on an actual robotic WAAM system and experimentally evaluated.


Objective To probe the possible ways and relative factors of infection of human papillomavirus (HPV) and high recurrence rate of condyloma acuminatum(CA) in mid aged women.Methods 50 cases over 45 age women with CA were divided into two groups(A group:28 cases with CA only,B group:22 cases with CA complicated other diseases).By acetic acid whited test,the lesion was removed by microwave.Patients were followed up monthly then. Results A group was treated 132 times,4.71 times per case;B group 147 times,6.68 times per case( t=4.10,P 0.01).Conclusion Mid aged women are succeptibles of HPV,family infection and indirect infection are the main transmitted ways.CA complicated other diseases has higher recurrence rate.


We prove that the product p (x)∇2mδ (x) of a homogeneous polynomial of degree j in n variables, p, and the iterated Laplacian of the Dirac delta function is of the form p (∇) q (∇) δ (x) for some polynomial q if and only if p (x) = |x| pk (x) for some harmonic homogeneous polynomial of some degree k, j = 2l + k. We also show that the product p (x)∇2mδ (x) , where p is homogeneous of degree j, vanishes for all m > j if and only if p is a harmonic polynomial.


OBJECTIVE To Study the location of lipopolysaccharide(LPS) on human gingival fibroblasts(HGFs) surface.METHODS We observed the immunofluorescence of HGFs surface to study the LPS-binding on HGFs with a fluorescence microscope.RESULTS It was demonstrated that FITC-LPS could bind to the receptor of cells.FITC-LPS bound to HGFs more strongly with the increasing concentration of LPS.LPS binding could be partly blocked by preincubation of HGFs with anti-CD14 monoclonal antibody.CONCLUSIONS The results indicate that LPS can bind to HGFs and the modulation of HGFs function depend on mCD14.


In this paper, the linear quadratic Nash games for infinite horizon multiparameter singularly perturbed systems (MSPS) are discussed. The uniqueness and the asymptotic structure of the solution to the generalized cross-coupled multiparameter algebraic Riccati equations (GCMARE) are newly established without the nonsingularity assumptions for the fast state matrices. The main contribution of this paper is that a construction of high-order approximations to a strategy that guarantees a desired performance level on the basis of a new iterative technique is proposed. As a result, it is shown that the high-order accuracy strategy improves the performance.